Entry Entry Name Protein names Gene Names Organism Gene Ontology (biological process) Gene Ontology (cellular component) Gene Ontology (molecular function) T: Peptide sequences N: Peptides N: Sequence coverage [%] N: Q-value N: Score Intensity CKD II_1 Intensity CKD II_2 Intensity CKD II_3 Intensity Healthy_1 Intensity Healthy_2 Intensity Healthy_3 Intensity MMVD_1 Intensity MMVD_2 Intensity MMVD_3 Intensity MMVD C WOAZ_1 Intensity MMVD C WOAZ_2 Intensity MMVD C WOAZ_3 Intensity MMVD WAZ_1 Intensity MMVD WAZ_2 Intensity MMVD WAZ_3 A0A059WHJ1 A0A059WHJ1_CANLF Prominin 1.s1 splice variant Canis lupus familiaris (Dog) (Canis familiaris) microvillus membrane [GO:0031528] AKYYRRMDSEDVYDDMENGN;NTSLSDVKRNLEQSLN;PISVLFQIVQVF;VGISFLFCWILMT 4 7.3 0.99453 -0.12367 0 0 0 0 0 0 0 0 6.85287 0 0 10.2303 0 6.30268 6.87123 A0A068PC33 A0A068PC33_CANLF Mammaglobin B protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] KLLRVLVLVALPL;NFALMMETMVSP 2 25 0.9458 0.05044 0 0 8.57664 0 0 0 0 0 0 0 0 0 0 0 0 A0A075EAM8 A0A075EAM8_CANLF Erythropoietin receptor EPOR Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] erythropoietin receptor activity [GO:0004900] DPLILTLSLILVLILLLLAVL;DPLILTLSLILVLILLLLAVLAL;ILVLILLLLAVLALLSH;LILTLSLILVLILLLLA;LILTLSLILVLILLLLAVL;LILVLILLLLAVLAL;LSLILVLILLLLAVL;LSLILVLILLLLAVLAL;LSLILVLILLLLAVLALL;LSLILVLILLLLAVLALLSHRR;LSLILVLILLLLAVLALLSHRRTL;LTLSLILVLILLLLAVLALL;PLILTLSLILVLILLLLA;PLILTLSLILVLILLLLAVLA;SLILVLILLLLAVLAL;SLILVLILLLLAVLALL;TLSLILVLILLLLAVL;TLSLILVLILLLLAVLAL 18 13.3 0.43671 0.50951 8.73802 0 4.67395 4.9721 7.76527 0 6.40633 0 8.17398 5.80263 0 4.30078 6.10635 9.25751 7.03155 A0A0A0QI14 A0A0A0QI14_CANLF Homeobox A1 HOXA1 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] YALNQEAEVSG 1 11.2 0.995 -0.19044 0 11.873 0 0 11.3872 0 0 0 0 0 0 0 0 11.742 0 A0A0B4J199 A0A0B4J199_CANLF Fibroblast growth factor 23 (Fibroblast growth factor 8B) FGF8B FGF23 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; calcium ion homeostasis [GO:0055074]; cell differentiation [GO:0030154]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular phosphate ion homeostasis [GO:0030643]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334]; regulation of phosphate transport [GO:0010966]; response to sodium phosphate [GO:1904383]; vitamin D catabolic process [GO:0042369] cytoplasm [GO:0005737]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105] LSRKIPTKKRRKRPVR;SSWGSLTHLYTAT 2 9.3 0.99056 -0.26866 0 0 5.90031 0 0 0 0 0 0 0 0 0 0 0 0 A0A0C4UNG3 A0A0C4UNG3_CANLF Cytochrome c oxidase subunit 3 COX3 Canis lupus familiaris (Dog) (Canis familiaris) aerobic electron transport chain [GO:0019646] membrane [GO:0016020]; mitochondrion [GO:0005739] cytochrome-c oxidase activity [GO:0004129] GVSVTWAHH;LFIVSEVFFFAGFFWAFYHSSLAP 2 12.6 1.0038 -0.80421 0 0 0 0 0 0 8.74376 0 0 0 0 0 0 0 0 A0A0C4UPG4 A0A0C4UPG4_CANLF Cytochrome b CYTB Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] SPDLLGDP;VGRGLYYGSYLF;VHLLFLHETGSNNPSGITS 3 10.3 0.94615 0.05044 0 0 0 0 0 0 10.3025 0 0 0 0 0 0 0 0 A0A0E3N0I3 A0A0E3N0I3_CANLF Muellerian-inhibiting factor Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; Mullerian duct regression [GO:0001880]; urogenital system development [GO:0001655] extracellular space [GO:0005615] growth factor activity [GO:0008083] AGAADGPC;REPAEPPPSAD 2 3.3 1.0027 -1.4049 0 0 0 0 0 0 0 0 0 0 0 0 10.4807 0 10.1759 A0A0E4AY72 A0A0E4AY72_CANLF Mucin-like 1 MUCL1 Canis lupus familiaris (Dog) (Canis familiaris) KILALLVLVAVSTFLVSG 1 16.1 0.97375 0.048313 0 0 0 0 6.46787 0 0 0 0 0 0 0 0 0 0 A0A0G2Y7A6 A0A0G2Y7A6_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP9Y Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] ASKKQREKLLELIRRL;CEKGGANLIKELIDDFIFPASKV;DFFESNVLQLDPSLLT;DHMMKRMSYRRQKRWWNAYILFYER;FMHNRMQYSL;FQTPEKKYHIGCEKGG;GEYMGEVFDHMMKR;GFHTKKIVR;HNRMQYSLEYF;KRLLIKKLPPV;LLIKKLPPVLAI;LLIKKLPPVLAIQ;LQINQVVIHEDFI;TVKRLLIKKLPPVLAIQL;TVKRLLIKKLPPVLAIQLK;TVKRLLIKKLPPVLAIQLKR;VKRLLIKKLPPVLAIQLKRFD;YYVPRGFWKQFR 18 6.6 0.98299 -0.25195 0 0 0 0 0 0 0 0 7.17253 0 0 0 0 0 0 A0A0K0KPZ2 A0A0K0KPZ2_CANLF Olfactory receptor OR0007 OR0007 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] APDHDMIVSMFYSI;AYDRYVAIYNPLLYSVGMS 2 15.9 0.99342 -0.16261 0 0 0 0 0 9.40152 0 0 5.53934 0 0 0 0 0 0 A0A0K0KQQ8 A0A0K0KQQ8_CANLF Olfactory receptor OR0184 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLALRLPFCGP;VLCFVPCIFIYTR 2 8.3 0.98775 -0.40053 0 0 0 13.0772 0 0 0 0 0 0 0 0 0 0 0 A0A0U3L6B6 A0A0U3L6B6_CANLF CD1a8 protein canCD1a8 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] LVWWLWKRW;NHIRDWQLEYPFQIQLV;QLAYQGSDLL;QLAYQGSDLLSFQNTSWRP 4 13.7 0.98851 -0.34409 0 0 10.1342 9.34507 0 9.11163 0 0 8.09624 0 0 0 0 0 0 A0A0X9NPA2 A0A0X9NPA2_CANLF Acetylcholine receptor subunit epsilon Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] DTEAYTENGE;EAALLRHQH;KIDIDTEAYTENGEWA 3 10 0.98975 -0.26542 0 0 0 0 0 0 0 11.9103 0 0 0 0 0 0 0 A0A140G348 A0A140G348_CANLF Cytochrome c oxidase subunit 2 COX2 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] LTVKTMGHQWYWSYEYTDYEDLNF;TVWTILPAIILILIALPS;YYGQCSEICGSNHNFMPIVL 3 27.3 0.95387 0.049243 0 0 0 0 0 0 7.53512 0 0 0 0 0 0 0 0 A0A140KFN6 A0A140KFN6_CANLF MHC class II antigen beta chain DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] GVIESFAVQRRVEPTVT;VGEYRAVT;YNREENVRFDSDVGEYR 3 13.9 0.97983 0.046227 0 0 0 0 0 0 0 0 0 0 4.91729 0 0 0 0 A0A172R3U9 A0A172R3U9_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] DLHPWLPSAME;LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL 6 15.7 0.98501 0.035491 0 0 0 0 0 0 9.25762 0 9.06523 0 0 0 0 0 0 A0A172R7X3 A0A172R7X3_CANLF Cytochrome b CYTB Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] RSMMFRSPSQCLFWLLVA;SPDLLGDP;VHLLFLHETGSNNPSGITS;WYFLFTYAI 4 14.2 1.0016 -1.806 0 6.92315 0 0 0 5.53534 11.511 5.99286 0 0 0 0 6.03545 0 0 A0A172R8A3 A0A172R8A3_CANLF ATP synthase protein 8 ATP8 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] YPENPMTKSAKIASQ 1 22.4 0.95182 0.053888 0 0 0 0 0 0 0 8.04881 0 0 0 0 0 0 0 A0A172R8X1 A0A172R8X1_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;NLTTQGLKFSYPSNY;PLMEHNQTIQTL 6 16.3 0.94702 0.080495 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.86999 A0A172R9F2 A0A172R9F2_CANLF Cytochrome c oxidase subunit 2 COX2 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] ILPTIILILIALPSLRILY;LTVKTMGHQWYWSYEYTDYEDLNF;VETVWTILPTIILILI 3 21.6 0.98379 -0.2478 0 0 5.00306 0 0 0 0 0 0 0 0 0 0 0 0 A0A172R9X7 A0A172R9X7_CANLF Cytochrome b CYTB Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] SPDLLGDP;VHLLFLHETGSNNPSGITS;VTHICRDVNYSWII 3 10.8 0.93597 0.060945 0 0 0 0 0 6.25151 0 0 0 0 0 0 0 0 0 A0A172RBL5 A0A172RBL5_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] FLLIRFHPLMK;LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN 5 13.7 0.98519 -0.25809 0 0 0 0 0 0 0 0 0 0 0 0 8.68306 9.56991 0 A0A172RCF5 A0A172RCF5_CANLF Cytochrome b CYTB Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743]; respiratory chain complex III [GO:0045275] metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121] GVNYGWIIRYMHAN;SPDLLGDP;VHLLFLHETGSNNPSGITS 3 10.8 0.98459 -0.25497 0 0 0 0 0 0 9.56348 0 0 0 0 0 0 0 0 A0A172RD47 A0A172RD47_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;TIQTMKLSMNFKLDYFS 5 14 0.98053 0.046227 0 0 0 0 0 0 0 0 0 6.46705 0 0 0 0 0 A0A172RE81 A0A172RE81_CANLF Cytochrome c oxidase subunit 1 (EC 7.1.1.9) COX1 Canis lupus familiaris (Dog) (Canis familiaris) oxidative phosphorylation [GO:0006119] mitochondrial inner membrane [GO:0005743]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872] FEEPTYVIQK;ISLTAEMLM;MPRRYSDYPDAYTTWNTVS;NIEWLHGCPP;PPYHTFEEPTYVIQK;TAHAFVMIFF 6 12.1 1.0017 -1.4659 0 8.80996 7.83384 9.39658 10.7407 0 0 0 0 0 0 0 0 0 10.0086 A0A172RGE0 A0A172RGE0_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;SHSITPTTIPLMTMPHYLK 6 17 0.94868 0.049553 0 0 0 7.26209 0 0 0 0 0 0 0 0 0 0 0 A0A172RHX0 A0A172RHX0_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] IILTLPIIMSST;LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL 6 15.8 0.98842 -0.26453 0 0 0 0 0 0 0 0 0 0 0 0 0 11.7969 0 A0A172RJL1 A0A172RJL1_CANLF NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) ND2 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] PEVMQGITLMSGMILLTWQKT 1 6.1 0.98652 -0.24585 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82421 A0A172RNJ9 A0A172RNJ9_CANLF Cytochrome c oxidase subunit 3 COX3 Canis lupus familiaris (Dog) (Canis familiaris) aerobic electron transport chain [GO:0019646] membrane [GO:0016020]; mitochondrion [GO:0005739] cytochrome-c oxidase activity [GO:0004129] IVSEAFFFAG 1 3.8 0.98724 -0.22805 0 0 0 0 0 0 9.30761 0 0 0 0 0 0 0 0 A0A172RNN0 A0A172RNN0_CANLF NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) ND4 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial membrane [GO:0031966]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] FMGSLNFLMIQYWIQ;HLTRKKLYISMLILLQLFL;TFTASELIFF 3 9.6 0.95224 0.04941 0 7.35173 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A172RNX9 A0A172RNX9_CANLF NADH-ubiquinone oxidoreductase chain 4L (EC 7.1.1.2) ND4L Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] KPIVLLVFAAC 1 11.2 0.99224 -0.17967 0 0 0 0 0 0 0 0 0 9.65573 0 9.58894 0 0 0 A0A172RPN9 A0A172RPN9_CANLF Cytochrome c oxidase subunit 2 COX2 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] LTVKTMGHQWYWSYEYTDYEDLNF;TVWTILPAIILILIALPS;VLYIISLMSTTKLT 3 24.7 0.98928 -0.22245 7.79123 0 0 0 0 0 0 6.44761 0 0 0 0 5.8714 0 0 A0A172RQ48 A0A172RQ48_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;PYYVKTATSYAFTISMIPTMMF 6 17.5 0.97421 0.046947 0 0 0 0 0 0 0 0 0 0 0 0 7.44832 5.80077 0 A0A172RRN6 A0A172RRN6_CANLF Cytochrome c oxidase subunit 2 COX2 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] LTVKTMGHQWYWSYEYTDYEDLNF;TVWTTLPAIILILIALPSLRIL 2 20.3 0.97419 0.046699 0 0 0 0 0 0 0 0 0 0 0 0 8.22236 0 0 A0A172RRT4 A0A172RRT4_CANLF NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) ND2 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] TLMTLSTFMLFMLN 1 4 0.86585 0.1445 0 8.79591 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A172RRX5 A0A172RRX5_CANLF ATP synthase subunit a ATP6 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] NRLISIQQWLIQLTSKQMLVIHNQ 1 10.6 0.97329 0.041303 0 8.13139 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A172RS04 A0A172RS04_CANLF ATP synthase subunit a ATP6 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] IHNQKGRTWALMLV 1 6.2 0.94012 0.060769 0 0 0 0 0 0 0 5.90917 0 0 0 0 0 0 0 A0A172RS56 A0A172RS56_CANLF NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) ND4 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial membrane [GO:0031966]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] FMGSLNFLMIQYWIQ;TFTASELIFF;VLIQTPLSYMGATALMIAH 3 9.6 1.0019 -0.67287 0 0 0 8.66189 13.6869 0 0 0 0 0 0 0 0 9.6465 0 A0A172RSP3 A0A172RSP3_CANLF NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) ND2 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] IVMLSSHWLLIWVGFEM 1 4.9 0.98718 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2032 A0A172RTP4 A0A172RTP4_CANLF NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) ND3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] MKFFLVAITFLLFDLKIALLLP 1 19.1 0.97292 0.046699 0 0 0 0 0 0 0 0 0 0 0 6.92232 0 0 0 A0A172RU01 A0A172RU01_CANLF NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) ND2 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] VLNLALYILMTLSTFMLF 1 5.2 0.97881 0.048313 0 0 0 0 0 5.64322 0 0 0 0 0 0 0 0 0 A0A172RU04 A0A172RU04_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;TMTFIYSGQETIISNWHWMTIQTM 6 17.7 0.97372 0.041303 0 8.60021 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A1B4XK94 A0A1B4XK94_CANLF DLA class I molecule DLA-88 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DAATGRMEPRAPWVEQ;IAVGYVDDTQFVRFDSDAA;VEQEGPEYWDRETRNFKETARTFRV;YYNQSEAGAHTLQWMYGCD 4 40.3 0.98956 -0.21933 0 0 0 0 0 0 0 0 0 0 10.4761 8.72857 6.27834 0 0 A0A1K0FUG1 A0A1K0FUG1_CANLF Globin A1 GLNA1 Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744] blood microparticle [GO:0072562]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] haptoglobin binding [GO:0031720]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] AAYQKVVAGVANALAHKYH;ANALAHKYH;EVGGEALGRLL;GKVNVDEVGG;GVANALAHKYH;KVVAGVANALAHKYH;PENFKLLG;PENFKLLGNVL;QKVVAGVANALAHKYH;TFAKLSELH;VANALAHKYH;VHLTAEEK;VHLTAEEKS;VHLTAEEKSL;VHLTAEEKSLISSMW;VVAGVANALAHKYH;YQKVVAGVANALAH;YQKVVAGVANALAHKYH 18 48.3 0.93915 0.060675 0 0 0 0 4.17217 0 0 0 0 0 0 0 0 0 0 A0A1L6Z7D2 A0A1L6Z7D2_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] GFIMAMAWFLL;LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMYSDPYINRFFKYLL;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL 6 17.5 0.99009 -0.267 0 0 0 0 0 0 0 0 0 0 0 0 0 13.1289 0 A0A1S7J0A8 A0A1S7J0A8_CANLF Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) 607076 CD14 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of endocytosis [GO:0045807]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; receptor-mediated endocytosis [GO:0006898]; toll-like receptor 4 signaling pathway [GO:0034142] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lipopolysaccharide receptor complex [GO:0046696]; membrane raft [GO:0045121] lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; lipoteichoic acid binding [GO:0070891] AVLQRVGGFA;DDDFRCFCNFTDPQ;ELQRWLKP;LRLRRLTVASAQ;VLCVSETSL 5 14.2 0.14035 0.81463 11.1822 10.7685 0 4.87455 2.35955 0 10.3419 11.1285 0 0 0 0 10.9998 11.2778 11.2367 A0A1X9RK95 A0A1X9RK95_CANLF Sperm acrosome-associated 1 isoform X3 SPACA1 Canis lupus familiaris (Dog) (Canis familiaris) acrosomal membrane [GO:0002080] VEFGMCTV 1 4.1 0.99213 -0.16709 0 0 0 0 8.77732 0 0 0 0 0 0 0 0 0 0 A0A292G4N4 A0A292G4N4_CANLF DLA class I molecule DLA-64 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] TLTWQCDGEDQTQDTEVV 1 5 0.98214 -0.24997 0 0 0 0 0 0 0 0 13.5143 0 0 0 0 0 0 A0A2Z5WQD9 A0A2Z5WQD9_CANLF Sirtuin-1 SIRT1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; rDNA heterochromatin [GO:0033553] metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; p53 binding [GO:0002039]; transcription corepressor activity [GO:0003714]; transferase activity [GO:0016740] ADDDFDDDDDDDEGEEEEEAAAA;DDDDDEGEEEEEAAAA;DDDDEGEEEEEAAAAAA;DDDFDDDDDDDEGEEE;DDFDDDDDDDEGEEEE;DFDDDDDDDEGEEEEEA;EDSSSPERTSP;RCPRCPAD 8 6.9 0.92812 0.095486 0 4.14151 0 6.66135 0 0 0 0 0 0 0 0 0 0 0 A0A2Z6A9S4 A0A2Z6A9S4_CANLF Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) ADRB3 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] plasma membrane [GO:0005886] beta-adrenergic receptor activity [GO:0004939] PARLLPLREHRALR;VLVWVVSAAVS 2 6.2 0.99457 -0.12762 0 0 0 0 0 0 0 9.13124 11.3089 0 0 0 0 0 0 A0A3B0ITV2 A0A3B0ITV2_CANLF Adiponectin N ADIN Canis lupus familiaris (Dog) (Canis familiaris) FSGFLVYPDLAA;FTAGKAPHKSLSVM;GAPGATFS 3 10.5 0.98626 -0.42103 0 0 0 10.1553 0 0 0 0 10.7866 0 0 0 0 9.74611 0 A0A5F4BST2 CRUM3_CANLF Protein crumbs homolog 3 CRB3 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923] VGLVLLLRKLREKRQ;VLLAVGLVLLLRKL;VLLAVGLVLLLRKLREK 3 15.4 0.99508 -0.17352 0 0 0 6.16539 4.32963 0 0 0 0 0 0 0 0 0 0 A0A5J6CVW4 A0A5J6CVW4_CANLF MHC class I antigen DLA88 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] DAATGRMEPRAPWVEQ;IAVGYVDDTQFVRFDSDAA;QITRRKREAAGDAEHRRNY 3 28.2 0.9535 0.049843 0 0 0 9.74814 0 0 0 0 0 0 0 0 0 0 0 A0A5K1UVD6 A0A5K1UVD6_CANLF Oxytocin receptor OXTR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] oxytocin receptor activity [GO:0004990]; vasopressin receptor activity [GO:0005000] TWLGCLVASAP 1 2.9 0.9786 0.035491 0 8.83949 0 0 0 0 8.54878 8.92668 8.46087 8.76739 0 0 0 0 0 A0A654ICU0 A0A654ICU0_CANLF Gap junction protein CXNN Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] GGILEEVHS;LHSDSGSS 2 3.5 1.002 -1.4527 0 0 0 0 0 0 0 0 0 0 9.73781 0 0 0 0 A0A654ICZ6 A0A654ICZ6_CANLF Gap junction protein CXNK2 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] LSVLFIFRILL;LVHIFYIMRKE;VHIFYIMRKE;VHLQEEIEIEI;VLFIFRILLL;VLPFSAMSFHKD 6 15 1.0022 -1.3071 0 0 0 0 9.49333 10.3581 8.63027 15.4159 5.93899 0 0 0 4.97948 0 0 A0A654IDR1 A0A654IDR1_CANLF Gap junction protein CXNS Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] LVGQYFLYG;SGASGSSK 2 6.3 1.0034 -1.0701 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1007 0 A0A6N0C9H8 A0A6N0C9H8_CANLF Interferon regulatory factor 7 Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPPPPPGA;IFDFSTFFREMAEFRARRRRGSPYY 2 9.2 0.99062 -0.29771 0 0 0 0 0 0 0 0 0 0 0 0 0 9.20592 0 A0A6S4PUX1 A0A6S4PUX1_CANLF DLA class I alpha chain DLA88 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] AERHRNYLETTCVEWLRRYLEMGK;DAATGRMEPRAPWVEQ 2 22.1 0.99201 -0.29121 0 0 0 0 0 0 0 0 0 0 0 0 8.81356 0 0 A0A6S4PZ18 A0A6S4PZ18_CANLF DLA class I alpha chain DLA12 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DAATGRMEPRAPWVEQ;FQKWAAVVVPSGHEQRYTCHVQHEG;GSHTFQWMFGCDLGPGGR;IAVGYVDDTQFVRFDSDAA 4 20.9 0.99071 -0.29776 0 0 0 0 0 0 0 0 10.7132 0 0 0 0 0 0 A0A6S4Q1T4 A0A6S4Q1T4_CANLF DLA class I alpha chain DLA88 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DAATGRMEPRAPWVEQ;EHDRNYLE;GVAEHDRNYLE;GVAEHDRNYLETTCVEWLQRYL;TRAGSHSLRYFHTSVS 5 15 0.98332 -0.25182 0 0 0 0 0 0 0 0 10.0261 0 0 0 0 0 0 A0A6S4Q8C2 A0A6S4Q8C2_CANLF DLA class I alpha chain DLA88 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] EHDRNYLE;IAVGYVDDTQFVRFDSDAA;WDPQTRIFKETAQVYRVGLDTL 3 13.6 0.97572 0.046883 7.73877 8.13566 0 0 0 0 0 0 8.15071 0 0 0 0 0 0 A0A6S4Q8H6 A0A6S4Q8H6_CANLF DLA class I alpha chain DLA88 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] DAATGRMEPRAPWVEQ;IAVGYVDDTQFVRFDSDAA;YYNQSEAGSHTIQWMFGCD 3 28.2 0.98329 -0.25393 0 0 0 0 0 0 0 0 0 0 8.84903 0 0 0 0 A0A7D3V0R9 A0A7D3V0R9_CANLF MHC class I antigen DLA88 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] DAATGRMEPRAPWVEQ;EHDRNYLE;QDAYDGADYIALNGD 3 21.5 0.99213 -0.035481 0 13.1737 0 12.8784 0 0 13.4265 0 13.5582 0 13.2279 0 0 0 0 A0A7D6JAV2 A0A7D6JAV2_CANLF Cytochrome c oxidase subunit 1 (EC 7.1.1.9) COI Canis lupus familiaris (Dog) (Canis familiaris) "electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872] FDPAGGGNPILYHH;TAHAFVMIFF 2 10.7 0.93973 0.06096 0 0 0 0 0 0 0 11.688 0 0 0 0 0 0 0 A0A7D6JYG6 A0A7D6JYG6_CANLF Cytochrome c oxidase subunit 1 (EC 7.1.1.9) COI Canis lupus familiaris (Dog) (Canis familiaris) "electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872] DMAFPRMNNMSFGL;TAHAFVMIFF 2 10.7 0.94333 0.061114 0 0 0 0 0 0 0 0 8.55094 0 0 0 0 0 0 A0A7I9BAT5 A0A7I9BAT5_CANLF MHC class I antigen DLA-88 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] DAATGRMEPRAPWVEQ;EHDRNYLE;GVAEHDRNYLE;GVAEHDRNYLETTCVEWLQRYL;IAVGYVDDTQFVRFDSDAA 5 29.8 1.0019 -1.3053 0 0 0 0 0 7.62271 0 0 0 12.7647 0 9.08584 0 10.1173 0 A0A7R6QEM4 A0A7R6QEM4_CANLF DLA class II antigen Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] GVSETSFLA;MLGQPNTL;SETSFLAKGDH 3 8.6 0.99311 -0.046092 9.28448 7.90845 0 7.31125 13.9001 0 8.19584 8.38254 14.5358 7.67821 8.02851 13.6781 7.81852 8.23587 0 A0A7R6QLE0 A0A7R6QLE0_CANLF DLA class II antigen Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] ATVDTVCRHNYGVEELY;LIFLGLGLIIRHRSQKG;VGEYRAVT 3 15.6 0.98921 -0.26276 0 0 0 0 0 0 0 0 0 0 0 8.58417 0 0 0 A0A7R8GV98 A0A7R8GV98_CANLF Interferon 1IB1 IF1IB1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response to virus [GO:0051607]; positive regulation of immune response [GO:0050778] extracellular region [GO:0005576] cytokine activity [GO:0005125] DQPLHTLRHIHSQLQACAQPPA 1 11.8 0.95962 0.04905 0 0 0 0 0 0 9.49833 0 0 0 0 0 0 0 0 A0A8C0LQF5 A0A8C0LQF5_CANLF Uncharacterized protein GRAP Canis lupus familiaris (Dog) (Canis familiaris) DDQNWYKAEL;RTPHSSVSTTVTSSRSWS;SDALGVPAINSGHLSLDRAG;SRSWSTLTPTGGGAGWADALASSL;SSRSWSTLTPTGGG 5 19.4 0.98815 -0.4912 9.06883 0 0 0 0 0 8.24888 9.90228 7.91594 0 0 0 0 10.8582 12.3285 A0A8C0LQH6 A0A8C0LQH6_CANLF RNA helicase (EC 3.6.4.13) DHX58 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] cytoplasm [GO:0005737] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DAAQAGLQ;HTHKDTVYNLI 2 3 0.98764 -0.22848 0 8.66782 0 0 0 0 0 0 9.63873 0 0 0 0 0 0 A0A8C0LQL0 A0A8C0LQL0_CANLF Tail specific protease domain-containing protein RBP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type peptidase activity [GO:0008236] AAEAFAHTMQDL;DLQEMSGDH;DSVSELWTHS;EAWDLAGV;IGQSDFFLTVP;ITIPTARSVGAADGGSWEGVGVV;LVFHSPGEMV;RYPTQRGVYL;SMPTQMALSASTGEA;SRVTSEGALAEMLAADL;VISYEPSTLEAPRQ;VLSPYVSRQVWEPLQ 12 12.3 0.93787 0.062667 0 0 0 0 0 0 0 0 0 0 0 0 0 5.28329 0 A0A8C0LQP7 A0A8C0LQP7_CANLF mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] mRNA 5'-cap (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723] DTETCFDICSCQ;FSAEFVTADCS;LKSKKKLEEGH;VVDVPEFLVYFPLLNE 4 20.8 0.85192 0.17065 0 8.50279 7.93416 0 0 0 0 0 8.78715 0 0 0 0 8.783 8.69125 A0A8C0LR18 A0A8C0LR18_CANLF Zinc finger and SCAN domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QKDPSQVSPG 1 2.5 0.9895 -0.26223 0 0 0 0 0 0 0 0 8.21184 0 0 0 0 0 0 A0A8C0LR42 A0A8C0LR42_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CSGCCCGA;HYHQRIHTGERPH;ITRTALCYHHRVH;IVNTYFTSISLC;KRFYFSIRFKQQQE;LSIHQKIH;LTYHQRSHRGERPYECS;SHSGEKPYECSEC;YFSIRFKQQQEQHVAEKPFR 9 13.6 1.0036 -2.2091 10.488 9.60478 10.0696 0 0 10.1966 10.4264 9.84116 9.70589 9.07682 0 9.33168 0 0 9.00692 A0A8C0LR50 A0A8C0LR50_CANLF Transcription factor BTF3 BTF3 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020]; nascent polypeptide-associated complex [GO:0005854] GPGCDPGDP;HFNNPKVQ;SLPPPRGGTRGQE 3 11.5 1.0036 -1.1057 0 0 0 6.78477 0 6.77255 0 0 0 0 7.3036 7.47857 0 0 0 A0A8C0LR69 A0A8C0LR69_CANLF Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) PLK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EQEILHRDLKL;LLAPAKHL;PSKHRTDEELQ;YHYFEDKENIYI 4 6.6 1.0021 -1.244 0 0 11.09 0 0 0 0 7.12732 0 11.7843 0 0 0 0 0 A0A8C0LRA8 A0A8C0LRA8_CANLF Ankyrin repeat family A member 2 ANKRA2 Canis lupus familiaris (Dog) (Canis familiaris) KGYTDIVKMLLD 1 3.9 0.94616 0.05044 0 0 0 6.58055 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LRF4 A0A8C0LRF4_CANLF Kelch domain containing 1 KLHDC1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] FGGRVLQTRMNDLHYL;RAQKEETENKYQ 2 6.9 0.98196 -0.24903 0 0 0 0 8.46532 0 0 0 0 0 0 0 0 0 0 A0A8C0LRI7 A0A8C0LRI7_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] YVMNTSLVISLCF 1 3.9 0.98503 -0.25879 0 0 0 0 0 8.64501 0 0 0 0 0 0 0 0 0 A0A8C0LRM2 A0A8C0LRM2_CANLF Runt-related transcription factor RUNX3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FNDLRFVGRSGRG;GGGGGGGG;GGGGGGGGK;VAGSSSGG;YYGASSGSYQFSMVA 5 10.8 1.0024 -0.9908 0 0 0 0 0 0 0 0 0 7.6756 0 8.86028 0 0 11.1519 A0A8C0LRQ8 A0A8C0LRQ8_CANLF Scm like with four mbt domains 2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] AGAGGALGSAGSGPGSAD;GEDRRADFWCDVVIADLHPV;WTEFLIRDLTGSR 3 12.8 0.98428 -0.23979 0 0 11.1302 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LRY5 A0A8C0LRY5_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] phosphatidylinositol phosphate binding [GO:1901981] LPSPPPPPAAAPPPPLSPL 1 4.1 0.95764 0.051429 0 0 0 0 0 8.68878 0 0 0 0 0 0 0 0 0 A0A8C0LS56 A0A8C0LS56_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G4A Canis lupus familiaris (Dog) (Canis familiaris) glycerol metabolic process [GO:0006071]; leukotriene biosynthetic process [GO:0019370]; phospholipid catabolic process [GO:0009395]; prostaglandin biosynthetic process [GO:0001516] cytoplasm [GO:0005737]; nuclear envelope [GO:0005635] calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]; phospholipase activity [GO:0004620] CLHVKPDVSELMFADWVEFSPYE;KYEENPLH;NITAEHIVSNDSSDSDD 3 6.8 0.99391 -0.16483 0 0 0 7.00787 0 0 0 0 0 0 0 12.8446 0 0 0 A0A8C0LS88 A0A8C0LS88_CANLF Follistatin (Activin-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] CRMNKKNKPRCVCAP;ISEDTEEEEED;SIGLAYEGKCIKA 3 11.5 0.99165 -0.20765 0 0 0 3.73173 0 0 0 0 0 0 0 0 0 8.89527 0 A0A8C0LSE0 A0A8C0LSE0_CANLF Zinc finger protein 446 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DADGQEMAPSSPQ;LVCPTRLMGE;SYACEECGCSFSW 3 7.4 0.99714 -0.11205 0 0 8.60511 0 0 0 0 15.7585 8.46984 0 0 0 0 0 0 A0A8C0LSG1 A0A8C0LSG1_CANLF FYVE-type domain-containing protein ZFYVE21 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EPQWVPDKECPRCMQCDAKFD;FYDKQLKVL;RGAGRFCLERRPAFPGGS;TGMSLQYAAPGAESV 4 18.9 1.0025 -1.2269 0 0 0 0 8.24788 0 0 11.1621 9.1853 0 0 0 4.29726 1.75198 0 A0A8C0LSQ9 A0A8C0LSQ9_CANLF EF-hand domain-containing protein KCNIP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325] AEGAGGVGGGEGGQAGENV;EGAGGVGGGEGGQAGENV 2 5.9 0.88043 0.13146 0 0 0 6.1841 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LSU1 A0A8C0LSU1_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fast-twitch skeletal muscle fiber contraction [GO:0031443]; intermediate filament cytoskeleton organization [GO:0045104] costamere [GO:0043034]; intermediate filament [GO:0005882]; neurofilament cytoskeleton [GO:0060053]; sarcolemma [GO:0042383] intermediate filament binding [GO:0019215]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; vinculin binding [GO:0017166] DANQLDLEE;HVLEDVSRSVRR;PGAQDRDEGSVYG 3 3.6 0.99585 -0.092556 0 8.16038 0 0 0 0 0 0 0 0 0 0 0 0 9.82761 A0A8C0LSY1 A0A8C0LSY1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] IDQWNRIENPEADPELYGQLI;MDAFLESHKL;MNEKGEITTNT 3 3.3 0.98518 -0.24078 0 0 0 0 10.4481 0 0 0 0 0 0 0 0 0 0 A0A8C0LT05 A0A8C0LT05_CANLF Cytidyltransferase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595] ETEAIRRIVERDGLSEA;VLLYPDYGPEELPTE 2 6.2 0.99346 -0.16459 0 0 6.53091 0 0 0 0 0 0 0 0 0 10.4059 0 0 A0A8C0LT53 A0A8C0LT53_CANLF Olfactory receptor family 10 subfamily D member 4 OR10D4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EGLETVLFF;FLYTVMAYDRFVAICYPLRYMVI;FYHFLGCTECFLYTVMAYDR;GISISKIRSA;GRQRAFSTCSAHITA;TFQLTYCASNEVDYYFCD 6 27.1 1.0018 -0.96458 0 11.9281 0 0 0 7.68503 11.7311 0 11.0493 0 0 0 0 0 0 A0A8C0LTA3 A0A8C0LTA3_CANLF [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B (EC 2.1.1.361) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] histone H4K20 methyltransferase activity [GO:0042799] RRRRRPQPRRAPALPV 1 3.5 0.9617 0.049233 0 0 0 0 0 0 0 0 0 0 8.37547 0 0 0 0 A0A8C0LTC4 A0A8C0LTC4_CANLF Osteoclast-stimulating factor 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] CRYCPVASG;DTNWWKGTSKGRT 2 6.1 0.98964 -0.52202 0 0 0 0 0 0 0 0 0 0 8.60681 0 0 9.85276 0 A0A8C0LTC7 A0A8C0LTC7_CANLF Solute carrier family 7 member 9 SLC7A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AYLFSWTSL;ERPIKVPIFIPILVTLISVFLV;LVIVAVIIIGGLVLLAQGNTRN;RNLPLAIIIG;TEELRNPFRNLPLAIII;VGPCLIIWVACGVLATLGALCFAE 6 20 1.0023 -0.72502 0 0 0 0 7.80265 7.07991 0 0 0 0 0 8.70525 9.40131 7.24479 8.79331 A0A8C0LTD0 A0A8C0LTD0_CANLF Reticulon RTN1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ATFGHVGGPPPSPASPSIQ;GDGDGDGD;IVFGSFLLL;QAEPGPLPRFPSA;TDEGHPFKTYLE 5 7.7 1.0014 -0.71001 11.2102 0 0 8.84884 10.1388 0 0 11.5667 0 0 0 0 11.5812 10.9661 11.9858 A0A8C0LTJ1 A0A8C0LTJ1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLALGGSQADQLRLGAH;GVGGRRAPRA 2 22.3 0.99447 -0.56096 0 0 0 0 0 9.53514 0 0 0 0 0 10.7768 0 0 0 A0A8C0LTK9 A0A8C0LTK9_CANLF 45 kDa calcium-binding protein (Stromal cell-derived factor 4) Canis lupus familiaris (Dog) (Canis familiaris) calcium-ion regulated exocytosis [GO:0017156] endoplasmic reticulum [GO:0005783]; Golgi lumen [GO:0005796] calcium ion binding [GO:0005509] AGAMVMRRQCWLWGHLGW;DGHVSWDEYKVKFL;GVPEAGAMVMRRQ;LSLPEFISLPVGTVE;TEDEFLSF 5 16.3 1.0024 -1.1562 0 0 0 0 0 0 0 11.3776 7.98954 0 9.41397 0 9.88174 0 0 A0A8C0LTL7 A0A8C0LTL7_CANLF Rhophilin-2 (GTP-Rho-binding protein 2) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165] DEDHQEKCLS;DGGCPGGY;GGCPGGYD;HYSEDSYLY 4 4.2 1.003 -1.9475 7.68482 7.78823 0 0 0 0 5.27374 0 0 2.23465 0 9.10523 0 0 0 A0A8C0LTQ3 A0A8C0LTQ3_CANLF AT-rich interaction domain 4A ARID4A TOMM20L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] double-stranded DNA binding [GO:0003690] AKIKTVKRLVKVKVL;DDYETAEKKENELL;DEKEEESSEEEDE;DEPAYLTVGTDVSAK;EAKIKTVKRLVKVKVLL;EDSCSSDSETE;ESETLDQLPLTNPE;ESETLDQLPLTNPEHFGTP;GNSGLVAK;IKTVKRLVKVKVLL;KIKTVKRLVKVKVLLK;KRLVKVKVLLKQ;TIDRRRKRLKKKD;TVKRLVKVKVLL 14 8.8 0.98746 -0.32398 4.49863 0 0 0 13.5653 5.60199 0 0 0 9.53265 0 0 11.1957 9.21449 8.31578 A0A8C0LTT0 A0A8C0LTT0_CANLF Desmocollin 1 DSC2 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLQIVVVNEAPY;EENTVDVEILRVTVEDKDLMNTAN;EWVRINENTGSI;GCCSERQE;GVITTSSS;INGPPFDFRLENIPDSDIERTWRLT;LVLLQHQTKVLKKR;QHQTKVLKKRHSKEKVLRRAKRR;SLGPFPLFLQQIQ;SYVTSVEEN;VLKKRHSKEKVLRR;VLRRAKRR;WHNFTQPRLGEKVQLCNQDDKH 13 17.4 0.99714 -3.9956 6.0414 9.61018 6.94498 0 0 10.1975 9.62165 0 10.5475 10.026 0 0 10.1196 9.03276 8.57308 A0A8C0LTT9 A0A8C0LTT9_CANLF Adhesion G protein-coupled receptor G6 ADGRG6 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DSLSLDNGESQTKFCGATAKGL;EEAPNCIYDSL;HWKWKPHSLLFLF;IDELAFKIDLNTTSRVNI;KDKEDIFTESFEQLC;TFTSPCYPNDY;VAFFCCRMFHS;WQNDFWNIPTLALKAESNLSCGSYL 8 10.1 1.0039 -0.83351 0 0 0 8.86545 7.85649 8.08693 2.2562 0 0 9.58459 0 1.70593 9.07516 9.37034 12.9711 A0A8C0LTV9 A0A8C0LTV9_CANLF GP-PDE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; membrane [GO:0016020] phosphoric diester hydrolase activity [GO:0008081] DFLELDCQLTRD 1 3.8 0.95287 0.05044 0 7.89191 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LTW2 A0A8C0LTW2_CANLF HhH-GPD domain-containing protein NTHL1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] "DNA binding [GO:0003677]; hydrolase activity, acting on glycosyl bonds [GO:0016798]" EPQDWRQQLENIRTMRSGKDAPVD;GAAPRRGGEEAAPL;GVGTLRVGRGQPGAE;VGFWRSKVKYIKQTSAILQ 4 20.1 0.98765 -0.39952 0 9.08515 0 0 0 0 0 0 0 0 0 0 0 0 13.1076 A0A8C0LTW6 A0A8C0LTW6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] HYRIHTGEKPYKCKE;LDSVLPQRHGMRT;PYKCKECGRAFTQHSSLTRHHRIHT 3 7 0.99221 -0.54196 0 0 0 0 0 0 0 0 9.72031 0 0 0 0 11.7453 0 A0A8C0LTX1 A0A8C0LTX1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell junction [GO:0030054]; cytosol [GO:0005829]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725] GVSRRPPTSPCCSK;LVRTWGPPAVL 2 4.8 0.93827 0.060873 0 0 8.59444 0 0 0 0 0 0 0 0 0 9.46001 0 0 A0A8C0LTX2 A0A8C0LTX2_CANLF Uncharacterized protein C1H19orf18 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PYGGYKQLQTSAN 1 6.2 0.94162 0.059725 0 0 0 0 0 0 0 0 0 0 0 0 8.67419 0 0 A0A8C0LTY2 A0A8C0LTY2_CANLF C2 tensin-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DIQEKYPDLFQVN;GDGRAASA;PKILFSSREEQQDILSKFGE 3 12.9 1.0037 -1.0542 0 12.9706 0 0 6.65478 0 0 0 0 0 0 0 7.53776 0 0 A0A8C0LU27 A0A8C0LU27_CANLF Ubiquitin associated and SH3 domain containing B UBASH3B Canis lupus familiaris (Dog) (Canis familiaris) collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279] cytoplasm [GO:0005737] protein tyrosine phosphatase activity [GO:0004725] EDQVLGETAPL;FIGLFVKEDS;PAWIPPSELAAAN;VGEALLESN;WLFSHVGDP 5 8.3 1.0031 -2.1247 9.06156 11.4529 0 0 0 0 8.7656 0 9.23738 6.77215 0 0 0 8.7305 8.20261 A0A8C0LU28 A0A8C0LU28_CANLF Slit guidance ligand 3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] extracellular region [GO:0005576] calcium ion binding [GO:0005509] CLSSPCKNNGTCSQDPVELY;DCEDNDCE;DNDCENNA;EINPDDCEDNDCENNATCV;GAPKSLGKLQKQ;GPHSEPPSCNAN;KRIGQIKSKKFRCSGSED;PPRRDLSE;QTSPCDQYECQ;TFSNMSHLSTLILSYN;VEEVERHLE;YKEPGIARCSSP 12 9.1 1.0036 -1.1044 0 0 0 0 0 0 0 0 9.88944 0 0 0 0 0 0 A0A8C0LU36 A0A8C0LU36_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AFWVLAQLMTDDRHAM 1 2.4 0.96206 0.049233 0 0 0 0 9.08693 0 0 0 0 0 0 0 0 0 0 A0A8C0LU57 A0A8C0LU57_CANLF tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] AARSSPARRTREP;ALAPLRTGPPKS 2 5 0.99133 -0.20606 0 9.24859 0 0 0 0 0 0 0 11.4833 0 0 10.799 0 0 A0A8C0LU59 A0A8C0LU59_CANLF Amidohydrolase-related domain-containing protein CRMP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" ESKGWVGSPITS;GAVILVHA;LGRDNGQSDR;SELSGSAVSSPGER;TSPPLSPDP;YLYQRVRIRSKVS 6 9.1 1.0028 -2.1705 8.1127 13.2461 0 0 4.29205 0 9.3529 0 0 0 0 0 0 0 0 A0A8C0LU68 A0A8C0LU68_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KIEAATQRLALSI;SQEAPPQRPPHRRP 2 13 0.99167 -0.20834 0 0 0 0 0 0 0 0 0 0 0 0 6.15838 9.63766 0 A0A8C0LU79 A0A8C0LU79_CANLF "Troponin T, slow skeletal muscle (Slow skeletal muscle troponin T)" PPP6R1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; slow-twitch skeletal muscle fiber contraction [GO:0031444] troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014] LNIDHMGEDQLREKAQ;VGGTRPQTINHTA 2 6.8 0.99047 -0.19618 0 0 0 12.6979 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LU90 A0A8C0LU90_CANLF 5-hydroxytryptamine receptor 4 (Serotonin receptor 4) HTR4 Canis lupus familiaris (Dog) (Canis familiaris) "chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of appetite [GO:0032098]" dendrite [GO:0030425]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594] HVLRYTVLHS;VSLAFVDLLV 2 5.2 1.0033 -0.87545 0 0 8.67338 0 0 0 0 0 11.3605 0 0 0 0 0 0 A0A8C0LUG5 A0A8C0LUG5_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DGMPIGYIPPTAP;GVTCTETSGLDSISDP;PNLDTAPYPNTVPDHSRS;RKLWRLWPERRPQRPTAAR;SITSTHPA;SLRKLWRL;SPTGGTAG;TSELTPESDKTPN;VTSDSVPTLIPQAASTRKVTS;WELGCGAALAAPG;WLDDVGCLGTEASL;WLSELACRGSEGQ;WLSELACRGSEGQLELCPHRGWKAH 13 10.6 1.0028 -2.5647 7.99543 8.56301 9.69876 7.26275 0 11.3898 0 6.03576 0 8.08364 9.29057 0 11.0658 0 4.764 A0A8C0LUH0 A0A8C0LUH0_CANLF "Troponin T, slow skeletal muscle (Slow skeletal muscle troponin T)" PPP6R1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; slow-twitch skeletal muscle fiber contraction [GO:0031444] troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014] ASLSSPVRFPPSSPSQTF;GVINFLKRFYLFI;LNIDHMGEDQLREKAQ 3 17.4 0.92617 0.10805 7.9982 0 0 0 0 7.72928 0 0 0 0 0 0 0 0 0 A0A8C0LUH3 A0A8C0LUH3_CANLF Rap-GAP domain-containing protein TSC2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TOR signaling [GO:0032007]; regulation of small GTPase mediated signal transduction [GO:0051056] nucleus [GO:0005634]; TSC1-TSC2 complex [GO:0033596] GTPase activator activity [GO:0005096] ARHAVLALL;DQNEFHGS;FVARQMAL;LGSLPYSLLFR;LVSHIQLHYKH;NEVVSYEIVLS;RGARDRVRSMSGGHG;VLPSFYEA 8 4.6 0.99903 -3.1388 0 0 0 0 0 0 0 14.4035 0 0 0 9.177 9.15188 0 0 A0A8C0LUI3 A0A8C0LUI3_CANLF RNA polymerase II-associated factor 1 homolog Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] Cdc73/Paf1 complex [GO:0016593] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] AGEVSPLVFSQKGWAS;FGSDADSEDDADSDDED;IFGSDADSEDDADS;IPFDPKFITYPFDQNRFV;MMSQAMIRGMMD;SDNDSDSGSDGGGQ;VPWMRKTEYISTEF 7 15.8 0.99238 -0.28996 5.20883 0 7.38301 0 0 6.37778 0 0 6.89494 0 4.44182 0 0 0 0 A0A8C0LUK1 A0A8C0LUK1_CANLF Desmoglein 3 DSG3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AAIGLLLLGLLLLLLAPLLLLT;GSAAIGLLLLGLLLLLLAPLLLL;GSAAIGLLLLGLLLLLLAPLLLLT;IVDREETPSFQ;IVSQEPAGTPMFLLSRHTG;KDVNDNFPMFKESQYSAH;PKTAQIKFV;SAAIGLLLLGLLLLLLAPLLL;SAAIGLLLLGLLLLLLAPLLLL;SLEVQQPESVRGQTLLGSQ 10 10.4 0.98672 -0.23303 9.29983 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LUK3 A0A8C0LUK3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [GO:0002486]; antigen processing and presentation of endogenous peptide antigen via MHC class Ib [GO:0002476]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] peptide antigen binding [GO:0042605]; signaling receptor binding [GO:0005102] GQEQRYRC;LSVTLAATLQRAE;TRRWEPPPPLST 3 18 0.98776 -0.46444 9.01444 10.0004 0 0 10.3682 0 0 0 0 0 0 0 0 0 0 A0A8C0LUN3 A0A8C0LUN3_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASPDLGPRGPD;GAPGQRPD;IVDTSGGPRFASDVQ;RVSPDHVT 4 5.7 1.0045 -1.1044 0 0 0 0 0 0 0 0 6.51343 0 0 0 0 0 0 A0A8C0LUP9 A0A8C0LUP9_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase) RNF157 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AEGNDVIEEEDGSPT;DTVSSMSGSYIA;LSPTSFNPIIS;QATEEFQNGIASYIPRDN 4 9 0.99345 -0.14282 0 0 0 0 0 9.26139 9.1899 0 7.23266 0 0 0 0 0 0 A0A8C0LUR7 A0A8C0LUR7_CANLF Dedicator of cytokinesis 7 DOCK7 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AEIEHEALIDGNL;AGKHSERSNHAEAAQ;EELALQWVVCSGSVRE;FEEETEQCADLCL;GKHSERSNHAEAAQ;ITAQLKIDISP;KIVHQDGKRMF;LDEHMFPV;LDRSNSWVNTGGPK;PAAITTLARSAIFS;PNTTYRNLLYIYPQ;PVVRFLHLLLDKLILLV;SDTVKMKEHQEDPEMLID;SPDEEEPIERLSVP;VGFYGTKFGD;VLSPEVPLPGMKWVDNHK;VTMSLSSLVGTSQNF 17 10.5 1.0017 -1.4135 5.21167 11.4744 8.98314 9.11629 8.01274 8.82706 6.85723 12.4987 0 11.0653 0 0 0 10.1325 8.83488 A0A8C0LUT2 A0A8C0LUT2_CANLF Protein phosphatase 1 regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; stress fiber [GO:0001725] phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] AAKRAEEELLLHDTRCWLNG;AEGEEAEPADRSPES;DEGEEGLTEPPFPESR 3 6.6 0.98704 -0.49945 0 8.94234 0 0 8.01759 0 0 0 0 0 0 0 0 0 0 A0A8C0LV25 A0A8C0LV25_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ENIYFPELP;KTSFAPFLKAHCWNRYGE;LHEIEPACSSIPETQ;LVCLIPYLQ;VQFDMLTVKENLRL;VWNFLKEHKAGHVIL 6 5.1 1.0022 -1.7965 0 0 7.76481 0 9.2764 9.92429 0 9.80653 5.69891 0 0 0 0 0 0 A0A8C0LVA8 A0A8C0LVA8_CANLF SAM-dependent MTase RsmB/NOP-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] IVMLYDFQDRKF;KKKKKSKTSLPKAP;PGRAKRAK 3 4.2 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 5.09288 0 0 0 A0A8C0LVB9 A0A8C0LVB9_CANLF Alpha-L-iduronidase IDUA Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] L-iduronidase activity [GO:0003940] EVPAPSGP;LLAALLAAPRAL;LVYVTLALDNPR;NGSAALRP;VDYWARPGPFSTRVHYVE 5 8.7 1.0029 -1.7427 9.61983 3.16545 0 2.77779 0 7.18349 0 0 0 0 0 0 0 8.19032 0 A0A8C0LVD3 A0A8C0LVD3_CANLF EF-hand domain-containing protein MYL5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DEELDAMLKEASGPINFTMFLN;EFKEAFTLMDQNRDGFIDKEDLK;GGVRGVSPIAPQAAA;PQICLPVSAGEGV;VPGPPEAAAWGGQGAA 5 26.3 1.002 -0.99279 0 6.87615 9.03941 0 0 0 12.8564 7.42097 12.9062 8.14149 0 0 0 9.37996 12.8948 A0A8C0LVE8 A0A8C0LVE8_CANLF VWFC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVESSYNVLPGK;HQVEMDQALQKEELQ;KALHFLRLNNNKIRNI;LSDLNQLVTLELEG;PEGECCSVCSDAASHLQL;PHQVEMDQALQKEELQ;YVFGHMEPGLEY 7 12.7 0.99125 -0.1351 0 0 8.20203 6.06089 8.39472 0 10.8682 0 0 0 0 0 0 0 10.3244 A0A8C0LVK9 A0A8C0LVK9_CANLF Nuclear factor 1 NFIA Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CYDISARTWWMDEFH;PEYREDFVLTVTGKKPPC;PNGSSQGKVHNPFL 3 8.8 0.98891 -0.52439 0 7.14639 0 0 0 0 0 0 0 0 0 8.14006 0 0 0 A0A8C0LVM0 A0A8C0LVM0_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEKPYKCNECGKAFTG;QTLILERHRLHDFDLREVQQDVNRC 2 9.4 0.98214 -0.2499 0 0 0 0 0 0 0 0 0 0 0 7.18616 0 0 0 A0A8C0LVN3 A0A8C0LVN3_CANLF Growth/differentiation factor 10 (Bone morphogenetic protein 3B) Canis lupus familiaris (Dog) (Canis familiaris) osteoblast differentiation [GO:0001649] extracellular region [GO:0005576] growth factor activity [GO:0008083] LLLLLPLL;LLLPLLLLL;LLLPLLLLLL;PPPPPRPLLLLLPLLLLLLRGA;PPRPLLLLLPLLLLLLRG;RPLLLLLPLLLLLL;RPLLLLLPLLLLLLRGA;VILSATFHLYMEPCWPRAREEPCRQ 8 9.7 0.99534 -0.092883 0 0 0 3.67084 0 0 0 0 7.19367 0 0 0 8.34509 10.6218 0 A0A8C0LVP8 A0A8C0LVP8_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] LLCNIIMLFYSLKDSP 1 10.3 0.9599 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.1265 A0A8C0LVS8 A0A8C0LVS8_CANLF Trafficking protein particle complex 8 TRAPPC8 Canis lupus familiaris (Dog) (Canis familiaris) EEVKELVTGEP;FNHPFHQKSLC;IHGSFTWLGQTQYKLQLKSQEI;KPFSRLTSEVHMRDP;LLNDVVSGSQPAEGLVAN;MPASDHEFL;QVTVFETSQQNSMPALI;RCKEKEVATQPSEKYTFADI;SVRGRQDLEIQGPRLNNTKEEK 9 10.5 0.98581 -0.4356 0 10.1846 0 0 7.28198 0 7.16812 11.7181 0 0 0 5.27075 0 7.04275 14.2975 A0A8C0LVW7 A0A8C0LVW7_CANLF SH3 and PX domains 2B SH3PXD2B Canis lupus familiaris (Dog) (Canis familiaris) superoxide anion generation [GO:0042554] cytoplasm [GO:0005737] phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176] AGYEEISSPDL;EEISSPDLEEKPS;LDKFPMEGGQKDP;LFRRSHIRDVAVKRLIP;QDEMNLERGAVVEVIQKNLEGW;QSSVGRDRELLNNQRDGRFEGRPV 6 10.8 1.0017 -0.91252 0 0 0 0 0 7.87689 12.6954 8.46402 10.4043 5.14082 0 0 0 0 0 A0A8C0LVX3 A0A8C0LVX3_CANLF Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) PRUNE2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] cytoplasm [GO:0005737] pyrophosphatase activity [GO:0016462] AEILLSALPDQR;CREERYKEKNEHHM;DFAALWHSDRS;DMNVDLVSPDSGL;FSTYGGGSEPTEN;IKDSYIPEVLEASEANE;INVLQETQFSAQGLSIE;ISLSDTSSPQTEKPQ;KDSYIPEVLEASEANESGA;KEKNEHHMDYI;KVYEKVDSWNLFEEGI;LDHIEVGDQ;LPETPSSS;LSILEEKFPSLP;LSYLTEPT;NPDILTHCDHDSY;PLCENQQSSPDHWNF;PQMQVLGGEKPLES;PRRQIAVYSQNLELCSQ;QETEQHIRAR;QPSSHSADYSPAD;RRASDSIFQPKSLE;SELSSEDVVPLPPIRDQA;SESKNENPSKLEMLGF;STEWWNASLQGGRPIQSAFERE;TEDGTPASTVSFPA;VECQETKWW;YQAVTHDNEWE 28 11.4 0.99685 -4.1332 9.64351 11.3094 10.4041 15.0205 10.5281 8.05989 0 15.664 6.26542 0 0 0 0 13.3547 7.16159 A0A8C0LVY2 A0A8C0LVY2_CANLF Gastric inhibitory polypeptide (Glucose-dependent insulinotropic polypeptide) GIP Canis lupus familiaris (Dog) (Canis familiaris) regulation of fatty acid biosynthetic process [GO:0042304]; regulation of insulin secretion [GO:0050796]; response to glucose [GO:0009749]; response to starvation [GO:0042594] extracellular space [GO:0005615] glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179] EESREQQGSLP;LLATLLLVVVMGEKAA 2 18.8 0.95619 0.049233 0 3.66664 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LW18 A0A8C0LW18_CANLF Sulfatase-modifying factor enzyme domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] PGQCGPGP 1 2.4 1.0031 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.56003 0 A0A8C0LW24 A0A8C0LW24_CANLF Zinc finger protein 577 LOC102155960 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] NYNNLVSLGYQ;TVPVEIPS 2 3.6 1.0037 -1.0689 8.14746 0 0 0 0 0 0 0 0 0 0 8.87267 0 0 0 A0A8C0LW27 A0A8C0LW27_CANLF Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis [GO:0000902]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666]; regulation of Rho protein signal transduction [GO:0035023] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; ruffle membrane [GO:0032587]; spindle [GO:0005819] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017] EEDSGGVA;HTRFLSQLLERRRQALCP;ILQHHGTDEERQDLTT;RLRESEQARALL;TWVSSPLQRTFSFFLSMT;VGPGVELL;YKELYARDKRFQQFIRKVTR 7 9.7 1.0005 -2.8096 0 6.72738 0 0 7.78882 0 0 0 11.3359 0 6.7765 0 9.57297 0 7.59492 A0A8C0LW30 A0A8C0LW30_CANLF Multiple C2 and transmembrane domain containing 2 MCTP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYASPAEDRRPSSNGI;DIEVWGKDSRKHEER;GVSVSDLCVCPLADPSE;KQRTRPLLINLSKKKVKK;NPEWNKVFTF;VYDRDLTTSDFMG 6 10.8 0.99117 -0.22195 6.65163 12.377 3.34752 7.61985 0 0 0 0 5.5213 0 0 4.29704 3.69677 0 6.06729 A0A8C0LW36 A0A8C0LW36_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] RIHSGAKPYECLQ;SECQKSFT 2 3.6 1.0022 -0.76381 0 0 0 0 0 0 0 0 0 0 0 0 9.95899 0 0 A0A8C0LW37 A0A8C0LW37_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GAGVPKAPAGGGKGRSLAAAGS;GVGERFRPGSDHIPGYPSH;GVPSASPVPGPA;PPGPGGLF;QVTLYDPA;RPEAAAPIP;SSPGDPDYSSSSEQSC;TFAELQERLEGIDGSEGPPGPLG;VLQLWPPPT 9 7.4 0.95036 0.049724 0 0 0 0 0 0 0 0 9.42511 0 0 0 0 0 0 A0A8C0LW44 A0A8C0LW44_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATLNSSELNATTGSLPSTTPMSPSA;EQVLVQSAAE;EVKNGPTYNCTEC;LAQQLQQHQQASSIDDS;NGSIRLSAPAA;PRSRSWQQRWAGEKTYFTMSYVI;RSWQQRWAGEKTYFTMSYVIYK;SAAEKDRISEM;VSTHMQVE 9 5.9 0.98677 -0.23123 0 0 0 0 0 0 0 12.7437 0 0 0 0 0 0 0 A0A8C0LW65 A0A8C0LW65_CANLF Vav guanine nucleotide exchange factor 2 VAV2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] IRPFPSEETAEND;KYYRTLEDIEK;LVPHSCLSCCAWAL;VARYNFAARDMRE 4 5.8 0.99383 -0.11988 7.61191 0 0 6.20889 0 0 0 0 9.40403 0 0 0 0 0 0 A0A8C0LW79 A0A8C0LW79_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EEDDEEDEEDGEPPYEPES;TDEDEELSPTFP;VTEGGAAHRDGRVRRG 3 5.4 0.99376 -0.16457 0 0 0 0 5.37556 0 0 0 0 0 10.0069 0 0 0 0 A0A8C0LW83 A0A8C0LW83_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] CSAKPVSAHISWLHNGKRLDRNME 1 3.6 0.97353 0.041303 0 0 0 0 0 0 0 8.91615 0 0 0 0 0 0 0 A0A8C0LW88 A0A8C0LW88_CANLF Transforming growth factor beta regulator 1 TBRG1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LAHEPLADTHLQH;LSQCSPTQSS;MQPQFEIVPEDDP;PRRRKKKKAKRTTNWKIITDR;VWRPGDGLPPQGLPEDDPTI 5 29.6 0.97629 0.047166 0 0 7.24079 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LW89 A0A8C0LW89_CANLF N-terminal EF-hand calcium binding protein 2 NECAB2 OSGIN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] SLEEFQLFFADGVLNEKELEDLFH 1 6.1 0.99406 -0.28554 0 0 0 0 0 0 0 0 13.2936 0 0 0 0 0 0 A0A8C0LWA6 A0A8C0LWA6_CANLF Signal transducer and activator of transcription STAT5B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DRPKDEVYSKYYTPVPC;FDSQERMFWN;QVKATIISEQQAKSLLK 3 5.8 0.98783 -0.22418 0 0 0 0 0 0 0 0 0 0 8.09392 2.77129 0 0 0 A0A8C0LWD3 A0A8C0LWD3_CANLF Phosphoserine phosphatase (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) Canis lupus familiaris (Dog) (Canis familiaris) L-serine biosynthetic process [GO:0006564] L-phosphoserine phosphatase activity [GO:0036424]; metal ion binding [GO:0046872] LVAVRRGRRRGP 1 3.1 0.95103 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.38681 A0A8C0LWE6 A0A8C0LWE6_CANLF Nucleophosmin Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of centrosome duplication [GO:0010824]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] AADEDDDDDGDDDD;AADEDDDDDGDDDDD;DDDDDDEDDDDDDDFDDEE;DDDDDEDDDDDDDFDDEE;DDDDDEDDDDDDDFDDEEA;DDDDDGDDDDDD;DDDDDGDDDDDDE;DDDDEDDDDDDDFDDEEAE;DDDDEDDDDDDDFDDEEAEEKA;DDDDGDDDDDDE;DDDDGDDDDDDEDDDD;DDDEDDDDDDDFDDE;DDDEDDDDDDDFDDEEA;DDDEDDDDDDDFDDEEAEE;DDEDDDDD;DDEDDDDDDDFDDEEAE;DDGDDDDDDEDDDDDDDFD;DEDDDDDD;DEDDDDDDDFDD;DEDDDDDDDFDDEEAEE;DEDDDDDGDDDDDD;DEDDDDDGDDDDDDE;DGDDDDDDEDDDDDDD;EDDDDDDD;EDDDDDGDDDDDD;EKAPVKKSIRDIPAKN;ELHIVEAE;GDDDDDDEDDDDDDD;GDDDDDDEDDDDDDDF 29 18.5 0.29927 0.63679 9.2167 6.79155 7.89712 8.74372 6.02019 9.26433 8.48099 7.12547 11.2998 0 5.43919 6.51101 7.8916 8.47358 7.90569 A0A8C0LWG0 A0A8C0LWG0_CANLF Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein DARS2 Canis lupus familiaris (Dog) (Canis familiaris) tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737] aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524] EIGGGSIRIHDAELQRYIL;HDLMSNAPDSLPPE;LSKPQGTVKAMC;VETPTLFKRT 4 8.9 1.0043 -0.8209 0 0 0 0 0 0 0 0 0 8.74194 0 0 3.90477 8.87329 0 A0A8C0LWG3 A0A8C0LWG3_CANLF BTB domain-containing protein KLHL14 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025] APKDQQQQPPQ;SMKLTGRESMKVDVRQS;VECYNLETNEWRYVS 3 6.1 0.99282 -0.14342 0 5.90499 0 8.61677 0 9.63934 0 0 0 0 0 9.66674 0 0 0 A0A8C0LWI0 A0A8C0LWI0_CANLF Regulator of G protein signaling 9 binding protein RGS9BP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] membrane [GO:0016020] GDGDADGDDL;GDGDGDGD;SGCLDLLEADMRRAL 3 12.2 0.99163 -0.27068 0 0 0 0 0 0 0 0 0 0 0 0 0 7.36641 0 A0A8C0LWJ0 A0A8C0LWJ0_CANLF Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 19) Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]" AYVFPGGV 1 2.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 10.8293 0 0 0 0 A0A8C0LWJ8 A0A8C0LWJ8_CANLF Cilia and flagella associated protein 99 Canis lupus familiaris (Dog) (Canis familiaris) AALRWEQKKAQS;QKADQKKEET;TLSPQKQAFILE 3 4.5 0.99034 -0.51058 0 0 0 0 0 0 7.12433 7.73654 7.59261 0 11.7089 0 0 0 0 A0A8C0LWL4 A0A8C0LWL4_CANLF DH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] LPGLGGGG 1 0.9 1.0035 -1.1044 0 0 0 0 0 0 0 0 11.5593 0 0 0 0 0 0 A0A8C0LWM2 A0A8C0LWM2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FYNQHVSTCLFKVQ;HVFLEANSV 2 21.3 0.99373 -0.19118 0 0 0 0 0 0 0 0 9.99081 0 0 0 0 9.41005 0 A0A8C0LWP6 A0A8C0LWP6_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum membrane [GO:0005789] cysteine-type deubiquitinase activity [GO:0004843] DRAKCFEKNEVDDKVNFHFILF;QEVSPKVYFMKQT 2 16.9 0.97536 0.046969 0 0 0 0 0 0 0 0 0 0 0 0 0 7.33316 0 A0A8C0LWU1 A0A8C0LWU1_CANLF UPAR/Ly6 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] phospholipase inhibitor activity [GO:0004859] LSCEVCRGSGPTC;VYFAGNVQAGLIS 2 12.7 0.99289 -0.19137 0 0 0 0 0 0 0 8.7174 0 0 8.29214 0 7.78162 0 0 A0A8C0LWU6 A0A8C0LWU6_CANLF Gelsolin-like domain-containing protein FLII Canis lupus familiaris (Dog) (Canis familiaris) actin filament binding [GO:0051015] DFDGLPSGIGKLASL;DSGLLNSEFCF;EPSEIKKHVPDDFWPPQP;KKLYLNSNKLDF;PLARKMRLRRRK;QWGDPDPCPPGSGQLESLQGE;RRRKDSAQDDQAK;SLDPRLFAEKINKN;TEKCSDFCQDDLA;VGRASDPDEAKLAE;VPECLYTLPSL 11 10.8 0.99217 -0.066005 14.6942 11.5511 14.5153 11.4832 12.1237 11.3052 14.3597 14.3814 14.4074 14.6664 0 14.8102 13.8623 13.8096 13.8583 A0A8C0LWW0 A0A8C0LWW0_CANLF Tudor domain containing 9 TDRD9 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283] ATP binding [GO:0005524]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676] DENPHDGE;EAFKTWQTCRQSGEL;GPPNCKAI;HIPPYGFLY;LKVSLELNVHSAEE;VHERTEDMDFLLLV;YTGVLCGLGWNPTTGAPI 7 6.6 1.0009 -2.7269 0 9.09067 0 0 7.5985 11.0482 0 11.0531 0 0 0 10.5626 0 0 0 A0A8C0LWW1 A0A8C0LWW1_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAPAEGDEAGSP;HECIRKSS;VLAHGGGG;VPVHVCGWVSASKGP 4 7.5 1.0007 -2.743 0 0 3.99648 0 0 0 9.95723 0 8.85941 0 0 0 0 0 0 A0A8C0LWX5 A0A8C0LWX5_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ALWLSFAPVADIIAHH;TLALVTICSLLG;YSKAFAGPSSSVFG 3 9 0.99285 -0.27123 0 11.2068 8.90545 10.1517 0 0 0 0 0 0 0 0 6.66846 0 0 A0A8C0LWX8 A0A8C0LWX8_CANLF mRNA decay activator protein ZFP36 (Zinc finger protein 36) Canis lupus familiaris (Dog) (Canis familiaris) "3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]" cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925] AAPGHPHV 1 2.5 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 7.26622 0 0 0 A0A8C0LWY1 A0A8C0LWY1_CANLF tRNA-intron lyase (EC 4.6.1.16) TSEN34 Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" nucleus [GO:0005634] nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] GQRPAPGSAPTQ;RRGAASGRNRSGDPGQ;RYSIYRDLWERGFFLSAAG 3 12 0.99206 0.0057235 9.54394 0 0 0 6.57623 0 0 0 0 0 7.4031 0 0 0 0 A0A8C0LX15 A0A8C0LX15_CANLF Cyclin E1 CCNE1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082] cyclin E1-CDK2 complex [GO:0097134]; cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] FSAPQLLDLCVLDVG 1 3.4 0.94912 0.053909 7.59567 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LX59 A0A8C0LX59_CANLF Potassium sodium-activated channel subfamily T member 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] DYYVVILCP;ESPEQWQRMYGRCS;GGGGGGGG;GGGGGGGGK;WGLTAGGTPPPPPGP 5 4.1 0.95531 0.053881 0 4.27366 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LX61 A0A8C0LX61_CANLF CASK interacting protein 1 CASKIN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DDIGSMFDDLADQLDAM;DELLVPAAVGPYATVQRRV;FQDSELSGELQAAMTGPAEGAAA;KPGHRKKI;PKPAKAAA;QFTTSQASKEIKQLLREA;SPVKPPEGS;VLKAGSAVNIPSDEGHIPLHLAAQ 8 8.7 1.0033 -1.579 0 0 0 7.08651 8.15623 0 11.5492 0 0 0 0 0 9.15188 7.07948 9.23785 A0A8C0LX91 A0A8C0LX91_CANLF Glycoside hydrolase family 38 central domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] membrane [GO:0016020] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GVRLLRSLVNLKQVI;GVWKQGFDISYS;PDEANSHYFALIDQ;SLTLLYPLAA;SSCLTGRPS;YSYDVPHTCGPDP 6 6.7 1.0035 -0.80421 0 0 0 6.63733 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LX95 A0A8C0LX95_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] PVGCLTGA 1 2.6 0.98945 -0.2657 0 11.7879 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LX99 A0A8C0LX99_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] RNA binding [GO:0003723] GFGFIHLETQ;HSRLFVGNLPPDI 2 16.1 0.98958 -0.26332 0 0 10.4809 0 0 0 0 0 0 0 0 10.0595 0 0 0 A0A8C0LXD6 A0A8C0LXD6_CANLF WD repeat domain 88 Canis lupus familiaris (Dog) (Canis familiaris) EGSVSSCHFSRDTSF;TATTVSYVKN 2 6.2 0.99022 -0.20492 0 0 0 9.59033 9.04538 0 0 0 0 0 0 0 0 0 0 A0A8C0LXE7 A0A8C0LXE7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] ETYGPFQIRIQ;SGSCPQRSASF 2 4.4 0.97946 0.035491 0 0 0 0 0 0 0 6.83289 0 0 0 0 0 0 0 A0A8C0LXF6 A0A8C0LXF6_CANLF JNK1/MAPK8 associated membrane protein Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] membrane [GO:0016020] ubiquitin protein ligase binding [GO:0031625] CTESPELYDWLYLGF;DVRRCCRGGWSRSSF;LLRPLLVKKI 3 9.5 0.98748 -0.50368 0 0 0 0 0 0 0 0 5.20132 0 5.97283 0 5.95873 0 0 A0A8C0LXG4 A0A8C0LXG4_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4D Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DHPGVSNQFL;DYDLSPKSMSR;GVKKLMHSSSLTN;LKILPLIAI;LPLKILPLIAI;TVGEEENSQPEA 6 7.6 1.0026 -1.1636 0 0 0 0 4.28562 0 0 0 0 0 9.52476 9.26139 6.34972 0 5.05407 A0A8C0LXJ0 A0A8C0LXJ0_CANLF FYVE-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AEMIAHRT;EAAEEEPQCLS;EALRHFDVL;EVIVLFCETVERALDFGY;LAKGQEEARPVLEVLPS;NPPARRRRL;PGVEGSPHREAS;RPFHTLLRKI 8 7.7 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 3.82222 0 0 0 0 A0A8C0LXJ3 A0A8C0LXJ3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSVAGMVLLILVVI;VTSDHQGTYRCYSSHN 2 11.5 0.93938 0.060769 0 0 0 0 0 0 0 0 5.05884 0 0 0 0 0 0 A0A8C0LXK2 A0A8C0LXK2_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] AWLKELAA;DEAEELRALSPA;PKTSKDQRDEPADAA;QEPDSPVTCDVQTICI;RWAFPYQTPN;SVMIGQMRDVVGAA 6 6.3 1.0024 -1.4461 4.6565 0 0 10.7676 0 0 0 10.4607 0 0 0 0 7.29802 0 0 A0A8C0LXK3 A0A8C0LXK3_CANLF Retinoic acid induced 14 RAI14 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] DEDVQKVL;EADQQDLLVL;EEIDVLKQ;ISVYRMHLLYAV;QELRITEEEIDVLKQ;SELSQLYKEAQA 6 5.6 1.0015 -2.6688 0 0 0 11.8438 0 0 0 0 5.46388 0 0 0 0 6.94907 0 A0A8C0LXL0 A0A8C0LXL0_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; receptor complex [GO:0043235] protein tyrosine phosphatase activity [GO:0004725] GVILFLILVGLLIFFLKKRI;NETRYEVQRN;TEAQYVFLHQCILRFLQQPDQAL;VSPSQWSF;VTIMSCISTSGGYGVI 5 7.8 1.0028 -1.8865 0 0 9.9656 0 0 0 0 8.54601 0 0 0 0 11.1775 0 0 A0A8C0LXL9 A0A8C0LXL9_CANLF Protein odr-4 homolog Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KPKIKDAVQ 1 2.1 1.0044 -0.80421 0 0 4.34844 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LXM1 A0A8C0LXM1_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] DVWSFGVVMWEV;GEVCYGRLRVPGQ;GGGGGGGG;GGGGGGLTVGDWL;IKFTLRDCNSMPGV;IMQLVGMLRGVGAG;LVVLLLLLICKK;RQRRDFLSEASIMGQ;VVTAAAAA 9 10.3 1.002 -0.67937 11.4328 0 0 0 4.76251 0 0 12.9841 12.3228 0 0 9.30652 12.0732 0 0 A0A8C0LXM4 A0A8C0LXM4_CANLF PX domain-containing protein SNX11 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050] endosome [GO:0005768]; membrane [GO:0016020] phosphatidylinositol phosphate binding [GO:1901981] ELNGRRRISI;QLSVPEIEACVQGRSP 2 8.7 0.67327 0.27912 10.8166 0 0 0 0 0 0 11.5947 0 0 0 0 0 9.64041 0 A0A8C0LXN8 A0A8C0LXN8_CANLF Solute carrier family 45 member 2 SLC45A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824] EFLIYERGVEVGCWGLCINSV;GALEPQFYKLLIKGFGGALGYLLG;GRVLGSEFQVMFFFSAL;HLEIGRVLGSEFQV;LNLLADFGGGALIC;LVSYIGLKGLYF;YHGDPYSA 7 17 0.99119 -0.2935 0 0 0 8.854 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LXR8 A0A8C0LXR8_CANLF Holliday junction regulator protein family C-terminal domain-containing protein MEF2A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] KKIQITRIMDERNRQ;SPDADDYF 2 5.3 1.0044 -1.1044 0 0 0 0 0 0 0 7.86648 0 0 0 0 0 0 0 A0A8C0LXT4 A0A8C0LXT4_CANLF Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) BRCA1 Canis lupus familiaris (Dog) (Canis familiaris) chordate embryonic development [GO:0043009]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair via homologous recombination [GO:0000724]; fatty acid biosynthetic process [GO:0006633]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020] BRCA1-A complex [GO:0070531]; BRCA1-BARD1 complex [GO:0031436]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AHVSSMPTSTSALKLPQ;DILTTQQRDTMQDNLIKLQQEMA;FSDDPESDPSSHRASELA;GSSEKIDLMASDPQ;KGKETELLIANYHGISQNPYHI;KIIHAFELDTGLQFADS;QECINPGLRREEIEESRRMT;QVPVRHNKTLQ;TPKEFMLVHKFARKH;VVNADLLCGRKEL;YLESGISL 11 10 1.0022 -1.3931 16.6481 0 10.3488 0 7.64602 15.5 10.2408 11.6454 0 0 8.64133 0 0 0 10.1973 A0A8C0LXT6 A0A8C0LXT6_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAEDSLLASPG;GGRRCADARGASGAGRA;PAAKKVAVKVLVR 3 12.3 0.9933 -0.14325 0 0 9.36438 0 4.98746 0 10.6617 8.75261 0 0 0 0 0 9.91824 0 A0A8C0LXW8 A0A8C0LXW8_CANLF Ras and Rab interactor 3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EEGEEEEEEDVMGP;LADEALPHRIKGY;SYSTSSTEEEPE 3 4.2 0.86139 0.18276 0 0 0 0 0 0 0 0 0 0 7.32508 0 0 10.0428 0 A0A8C0LXX7 A0A8C0LXX7_CANLF Matrix remodeling-associated protein 8 MXRA8 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] plasma membrane [GO:0005886] ADEGTYSC;LGYVLATLLLFILLLITVILATRQ;VLRCQSPRMVWTQDRL 3 10.8 1.0022 -1.0139 0 0 0 0 5.38802 0 0 0 9.17692 0 0 2.9649 0 0 0 A0A8C0LXZ2 A0A8C0LXZ2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HLRTHSPETHSECNT;TQHHRTHTGEK;VLTQHHTIHKGEKP 3 6 0.93365 0.099825 0 0 0 0 0 9.10179 0 0 4.26604 0 0 0 0 0 0 A0A8C0LXZ4 A0A8C0LXZ4_CANLF "WD repeat domain, phosphoinositide interacting 1" Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site [GO:0000407] lipid binding [GO:0008289] EPPMEAEAAESPPGGV;VQKGGAGI 2 3.8 0.98906 -0.5242 0 0 0 0 0 0 0 0 0 0 0 0 8.65532 8.47529 0 A0A8C0LXZ5 A0A8C0LXZ5_CANLF Leukosialin Canis lupus familiaris (Dog) (Canis familiaris) regulation of T cell activation [GO:0050863]; regulation of T cell migration [GO:2000404] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] AVLVAVLVVIVLLGLLLLWRQ;AVLVVIVLLGLLLLWRQRQKRR;ETSAIANGPPTIMAADSLE;LVAVLVAVLVVIVLLGLLLL;LVVIVLLGLLLLWRQ;LVVIVLLGLLLLWRQRQKR;QELNRTQLVAVLVAVLVVI;QLVAVLVAVLVVIVLLGLLLL;VAVLVAVLVVIVLLGLLLLWRQRQK;VAVLVVIVLLGLLLLWR 10 11.5 0.87397 0.12781 5.07429 4.5109 0 4.25407 0 0 8.35944 9.51952 4.379 0 0 0 4.77199 7.10182 0 A0A8C0LY21 A0A8C0LY21_CANLF Aspartate aminotransferase (EC 2.6.1.1) GOT2 Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] ATVVKKNNLF;GVAAAFHPGLAGAASARAS;STILTSPD 3 9.6 0.98891 -0.52455 0 0 0 0 0 0 0 0 0 0 0 0 8.81147 0 0 A0A8C0LY54 A0A8C0LY54_CANLF SP-RING-type domain-containing protein ZMIZ1 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357] nuclear receptor coactivator activity [GO:0030374]; SUMO ligase activity [GO:0061665]; zinc ion binding [GO:0008270] GSLSVVTTVWGVTNTSQS;GSSDQPHPSIQQALE;PGSGGFGA;PNYPGQRMPSQPSTGQYPPPTVN;SNSNDDLLSLFE;YPGGPNAPAGMGIP 6 8.8 1.0033 -1.6942 9.2175 9.12908 9.13612 10.3107 0 0 0 0 0 9.37184 0 8.90647 0 0 0 A0A8C0LY77 A0A8C0LY77_CANLF "Endoplasmic reticulum membrane sensor NFE2L1 (Nuclear factor erythroid 2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)" Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; regulation of transcription by RNA polymerase II [GO:0006357] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GCSQDFSLFSPEA;GGEDQTALSLEECLRL;LGGCSQDFSLFSPEAE;NLPVEEFNELLSKYQ;TLDGYGIHPKSIDLDNY 5 8.6 0.98252 -0.254 0 0 6.36997 10.125 0 0 0 0 7.88929 0 0 0 0 0 7.61839 A0A8C0LY78 A0A8C0LY78_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] retinol binding [GO:0019841] DTDYDNYLFFCMENTD;GCLVLPVTCGGRWT 2 12.6 0.875 0.12799 0 0 0 0 7.30159 0 0 0 0 0 0 0 0 0 8.79789 A0A8C0LY83 A0A8C0LY83_CANLF IGFBP N-terminal domain-containing protein ESM1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] CDRVTGKCLKFPFFQ;DDCGCCRVCAAGP 2 16 0.98149 -0.24885 0 0 0 0 0 0 4.19904 0 0 0 0 0 0 0 0 A0A8C0LY93 A0A8C0LY93_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 17 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DSLFIWTHSG;EACEDYSGCY;GTPCGPYETDLCVHGKCQK;MRWYQRCCQ;NYGIHYEYTVPVNHTAE;RQCHQEVCND;VHGKCQKI;YVRRGLWEKI 8 8 1.0028 -2.569 8.89303 0 8.8427 9.33168 10.2928 0 0 0 0 8.10135 0 0 0 0 0 A0A8C0LY94 A0A8C0LY94_CANLF Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) APOC2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; lipid transport [GO:0006869] chylomicron [GO:0042627]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; very-low-density lipoprotein particle [GO:0034361] enzyme activator activity [GO:0008047] AGIFTDQLLSMLKGDS;AHESQQDETTSSAL;AHESQQDETTSSALL;AHESQQDETTSSALLTQMQESL;AHESQQDETTSSALLTQMQESLYSY;DETTSSALLTQMQESL;DQLLSMLKGDS;FTDQLLSMLKGDS;GIFTDQLLSMLK;GIFTDQLLSMLKGDS;GTARSAAEDL;IFTDQLLSMLKGDS;LLSMLKGDS;LLVLLLVLLVLGFGECGRPGRR;SAAEDLYKKA;SAAEDLYKKAYPTTMDEKIRDIY;SAAEDLYKKAYPTTMDEKIRDIYS;TDQLLSMLKGDS;TMDEKIRDIYS;VLLLVLLVL 20 58.3 0 106.27 13.0246 13.5113 13.5389 11.6276 11.2195 11.6207 13.3584 14.1726 14.0914 12.6077 12.5213 12.4476 13.1004 14.2011 14.2471 A0A8C0LY95 A0A8C0LY95_CANLF Olfactory receptor family 10 subfamily D member 1K OR10D1K Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FYHFLGCTECFLYTVMAYDR;KEVKYSLRKVLQQVAF;QVLNNLVTP 3 14.5 1.0027 -0.75498 0 0 0 0 0 3.95838 7.46793 0 0 0 0 0 0 0 0 A0A8C0LYB1 A0A8C0LYB1_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APELCCPPPLPEGL;DPFYEDFL;PELCCPPPLPEGLP;QSDEEQVEAGAAENV;SLRGFLYEFCVGLSLGAH 5 16 1.0033 -1.5481 0 10.4075 0 0 0 0 9.04486 0 12.2628 0 0 9.14172 0 0 0 A0A8C0LYD9 A0A8C0LYD9_CANLF Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749] PKKLLLLPLL 1 2.6 0.98785 -0.32572 0 8.24944 0 0 3.62129 0 0 2.85904 0 0 0 0 7.38068 0 0 A0A8C0LYF9 A0A8C0LYF9_CANLF BTB domain-containing protein KCTD15 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] QEPQVPWPQSAG;QLQPMVRELERWQ;RTSKLLLPDDFKDFS 3 12.1 1.003 -0.85195 0 0 0 0 0 0 0 0 0 9.20906 0 0 0 0 0 A0A8C0LYG2 A0A8C0LYG2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVAPVETGMMFWAAP 1 7 0.98421 -0.24243 0 0 0 0 0 0 0 0 9.3733 0 0 0 0 0 0 A0A8C0LYG4 A0A8C0LYG4_CANLF Septin-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] GVGSPWRGRPP;PMSQLQSRLEPKPQPTVA;QTLENSEHTPMSQLQSRLEPKPQP;VGREVRREPWKGWHLSSGT;VPAAPTAD 5 7.2 0.98508 -0.2413 0 0 0 0 0 0 10.0293 0 0 0 0 0 0 0 0 A0A8C0LYI4 A0A8C0LYI4_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNSNIGEVLQAVILERHKSC;SLPSHRRIHTGE 2 6.3 0.93406 0.099099 0 0 0 0 0 0 0 0 0 0 0 0 9.59952 6.89385 0 A0A8C0LYK2 A0A8C0LYK2_CANLF Aurora kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VKIADFGW 1 2.9 0.98989 -0.26586 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.94111 A0A8C0LYM3 A0A8C0LYM3_CANLF Transmembrane protein 52 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATPFSDQMPEQHTH;DSWMWCGGERGQ;RLEPHGSWGLLPSQPPAPRR;VGLILLAVLLLLLCG;VLGVLAPGALLLLPPLLPLPQV 5 25.3 0.98685 -0.35718 0 0 0 0 4.01605 0 10.8311 4.37016 0 0 0 0 0 8.90479 4.40524 A0A8C0LYM5 A0A8C0LYM5_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" FAKQYYNLRYRAKVISDMLGA;IDHRGTNNLYQMKSQNPL;PHFTKRDEEILLKYLNF;PSFQSLAQFLG;RRQHEHAIHMMD;TQQEWTQYMMLEQ 6 11.5 0.99235 -0.065361 0 6.13424 13.0859 0 0 0 6.55116 6.3029 0 0 0 2.47493 0 12.1334 0 A0A8C0LYM6 A0A8C0LYM6_CANLF Actin-related protein 2/3 complex subunit 5 ARPC5 Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477]; regulation of actin filament polymerization [GO:0030833] Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634] actin filament binding [GO:0051015] PINTKSQAVKDRAGSIVLKVLI 1 14.6 0.97671 0.047261 0 3.82883 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LYP1 A0A8C0LYP1_CANLF Spondin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] DLYPYDAGTDSG 1 3.6 0.9524 0.05044 0 0 0 0 0 0 0 0 0 0 0 5.07262 0 0 0 A0A8C0LYP7 A0A8C0LYP7_CANLF Complement component C8 beta chain (Complement component 8 subunit beta) C8B Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579] CNGDNDCGDQS;CNGDNDCGDQSDEAN;CNGDNDCGDQSDEANC;EVTYEKNVAID;NEGSPCLGPASETLNC;QTCAQNDFKIGAAIKKIYV 6 10.5 0.99232 -0.0058269 0 5.96449 11.1857 0 0 0 0 5.98546 0 0 0 0 0 6.96694 3.10121 A0A8C0LYQ1 A0A8C0LYQ1_CANLF Sulfate transporter (Solute carrier family 26 member 2) SLC26A2 Canis lupus familiaris (Dog) (Canis familiaris) chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988] apical plasma membrane [GO:0016324] monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271]; solute:inorganic anion antiporter activity [GO:0005452] AATLASHFGKLNEKYNTS;AGSIPTGFMPPT;EVVDRELHKAGY;GVITALVLLLVLLVIAPL;KDLPKMWKVS 5 9.4 0.9958 -0.11412 7.29536 0 0 0 0 4.04789 0 0 0 0 8.78562 0 0 0 9.64981 A0A8C0LYR5 A0A8C0LYR5_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AYAIMLLALV;CCCCCCGACGAPT;CCCGACGA;GCCCCCCGAC;GCCCCCCGACGAP;LGDVSCRAVPFMEVS;PLGRAFLGCCCCCCG;TLPENVCNIVVAYLSTELTRQ;VGSMILAVPE 9 16.2 1.0029 -0.98527 0 0 0 0 0 0 0 0 3.51197 0 0 0 7.46418 0 0 A0A8C0LYS0 A0A8C0LYS0_CANLF Cytokine like 1 Canis lupus familiaris (Dog) (Canis familiaris) DIHNHCVLAKLRDFVASPQ 1 14.3 0.95353 0.049518 0 0 0 0 0 0 0 0 0 0 7.69411 0 0 0 0 A0A8C0LYS1 A0A8C0LYS1_CANLF RNA helicase (EC 3.6.4.13) DHX8 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex disassembly [GO:0000390] catalytic step 2 spliceosome [GO:0071013] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] AFGGNKAS;EYLSLVSKVCTELDNHL;KTSLSMKDVDQE 3 3 0.98642 -0.39356 0 0 9.50549 0 0 0 0 10.9321 0 0 0 9.46197 0 9.61276 0 A0A8C0LYS3 A0A8C0LYS3_CANLF RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) CTDP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] AGESLDQSVEEEEDDEDDGDEDDHL;EDDGDEDD;EEEDDEDDGDEDDH;EQHCQQMSNKGIFHF;ESLDQSVEEEEDDEDDGDE;EVAGVHGP;GARDAGKAAQRGGPSGPGGE;TAGESLDQSVEEEEDDEDDG 8 7 1.0033 -1.562 0 10.1397 0 7.51333 7.68292 7.46695 8.59723 7.75969 0 10.2722 0 0 0 0 9.87784 A0A8C0LYT4 A0A8C0LYT4_CANLF SMB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] CNCDYNCQH;DTSKETSSTPNK;EPEPTAPNKESAPTTS;GYSRDAICNCDYNCQHYM;PSLPPNTDTSKETSS;PVPTTTKEPEPTT;VDEAGSGL;VEAMLQTTTSP 8 9.1 1.0037 -1.6489 11.7445 3.89394 0 0 0 6.38123 9.83665 0 0 0 0 8.84072 0 5.05914 7.53636 A0A8C0LYU2 A0A8C0LYU2_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] SPLQTTLLPTAN 1 3.4 0.98597 -0.2583 0 0 0 0 0 0 0 0 8.54909 0 0 0 0 0 0 A0A8C0LYU8 A0A8C0LYU8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LPVDQTPQPGLPLDNAVRNPHLTT;VHLAQLGGQFFSLC 2 27.5 0.99308 -0.16051 0 7.80161 0 0 0 9.658 0 0 0 0 0 0 0 0 0 A0A8C0LYW2 A0A8C0LYW2_CANLF Signal recognition particle subunit SRP68 (SRP68) SRP68 Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "nucleolus [GO:0005730]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; signal recognition particle binding [GO:0005047] EELERLCESNRVDAKTKL;GGGGGGGG;GGGGGGSG;PGGGGGGG;SGGGRGAG 5 6.2 0.97216 0.048313 0 0 0 0 0 0 0 0 0 0 5.17568 0 0 0 0 A0A8C0LYW3 A0A8C0LYW3_CANLF Transmembrane protein 260 TMEM260 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NYSLWPWGSCD;TQLSFNIQALAIW 2 3.7 0.99251 -0.19361 0 0 0 0 9.44441 0 0 0 0 0 8.41671 0 0 0 0 A0A8C0LYW5 A0A8C0LYW5_CANLF WAPL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of cohesin loading [GO:0071922] DDLSESEDDDEDDCQ;EDDDEDDCQ;ESEDDDEDDCQ;FGFDDLSESEDDDEDDCQ;KGGNGSSK;LEEVTSVLEANSKI;LSESEDDDEDDCQ;LVNMETSCSFDS;METSCSFDSSLCS;PDSEELPGPPIVKPQ;SCLSVCNVTIQDTM;STPADLGEAGRLRKKAD;WGAERCLRVLESVTVHNPENQSY 13 11.2 1.0027 -1.8911 8.33101 0 0 0 7.64652 0 0 9.92521 9.99633 0 0 0 5.54 0 9.99647 A0A8C0LYX6 A0A8C0LYX6_CANLF Prohibitin Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743] DRFRGVQDIVKPIIFDC;DYDERVLPSI 2 12.9 0.98773 -0.37306 0 0 0 10.2814 0 0 8.55896 0 0 0 0 0 0 0 0 A0A8C0LYZ4 A0A8C0LYZ4_CANLF DUF4708 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AYIENCGAKVEA;QDILVSPVPGILSQIWVVM;VGVNDHKLIISKTSHRSKR 3 7.5 0.95213 0.05044 0 0 0 0 0 0 7.85425 0 0 0 0 0 0 0 0 A0A8C0LYZ9 A0A8C0LYZ9_CANLF SH3 domain-containing protein FYB2 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229] plasma membrane [GO:0005886] GGAAPQVGQVGGLGSGVS;GYVLIEHLDFK;QPVYESELASQTPE 3 5.4 1.0014 -0.70439 0 0 0 0 8.53559 8.62242 0 0 13.4861 0 0 0 9.56664 9.45966 0 A0A8C0LZ16 A0A8C0LZ16_CANLF Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) PRUNE2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] cytoplasm [GO:0005737] AEILLSALPDQR;CREERYKEKNEHHM;DELDTPDEADSFEYTGHGYYG;DFAALWHSDRS;DMNVDLVSPDSGL;FSTYGGGSEPTEN;IKDSYIPEVLEASEANE;ISLSDTSSPQTEKPQ;KDSYIPEVLEASEANESGA;KEKNEHHMDYI;KVYEKVDSWNLFEEGI;LDHIEVGDQ;LPETPSSS;LSYLTEPT;NPDILTHCDHDSY;PLCENQQSSPDHWNF;PQMQVLGGEKPLES;QETEQHIRAR;QPSSHSADYSPAD;RRASDSIFQPKSLE;SELSSEDVVPLPPIRDQA;SESKNENPSKLEMLGF;STEWWNASLQGGRPIQSAFERE;TEDGTPASTVSFPA;VECQETKWW;YQAVTHDNEWE 26 12.5 0.97532 0.047166 0 0 7.62673 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LZ31 A0A8C0LZ31_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SVRVVSLTVLVNQPQ 1 26.3 0.94926 0.053889 0 0 0 0 0 0 0 0 0 0 0 6.21694 0 0 0 A0A8C0LZ32 A0A8C0LZ32_CANLF SH3 domain-containing protein BCAR1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] LLFYLEQCE;PRERLLPPEAADGGV;QSRPLPSPPKFTSQD;QSRPLPSPPKFTSQDSPDG;QYTPMLPAT;SPPKFTSQDSPDGQYENSEG;TENVLAKALYDNVAESP 7 8.5 1.0018 -0.9662 0 8.79585 0 0 11.0672 0 8.96038 0 0 10.1335 5.8777 0 0 9.66315 0 A0A8C0LZ50 A0A8C0LZ50_CANLF Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) SLC66A2 Canis lupus familiaris (Dog) (Canis familiaris) "phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] ESPLLWQSIVM;GPTVQECSHPACPAVFCG;LQFSVCGLLQVL;MVLMWTSGD 4 18.9 0.98999 -0.2022 0 0 0 0 0 0 0 0 0 0 9.63085 0 0 8.60774 0 A0A8C0LZ60 A0A8C0LZ60_CANLF SH3 and PX domains 2B SH3PXD2B Canis lupus familiaris (Dog) (Canis familiaris) superoxide anion generation [GO:0042554] cytoplasm [GO:0005737] phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176] EGQDGMQDEFSLQPEEG;LDKFPMEGGQKDP;LFRRSHIRDVAVKRLIP 3 17.5 0.98117 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.91516 A0A8C0LZ88 A0A8C0LZ88_CANLF SH3 domain binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EDEDDSYMEPD;EPEDTLTHPPAYPPPP;NEDYEHEDEDDSY;PSEEVVKPRLFVPAVAPRPPGLKL;PTDNEDYEHEDEDDSYME;SYPTDNEDYEHED;TDNEDYEHEDED 7 10.5 0.98891 -0.52449 0 0 9.68734 8.03562 7.71191 0 0 0 0 10.8216 0 0 0 6.79857 9.00927 A0A8C0LZ97 A0A8C0LZ97_CANLF SH2 domain containing 4B SH2D4B Canis lupus familiaris (Dog) (Canis familiaris) EQLPRRAGFERNTKS 1 4.5 0.9567 0.053874 0 0 7.49081 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LZA1 A0A8C0LZA1_CANLF Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273]; ribosomal small subunit biogenesis [GO:0042274] nucleolus [GO:0005730] DNA binding [GO:0003677]; RNA binding [GO:0003723] RKKRKRKELRAKEKVAQAAEVVEVT 1 7.7 0.97893 0.035538 0 0 0 0 0 0 0 5.4274 0 0 0 0 0 0 0 A0A8C0LZB1 A0A8C0LZB1_CANLF mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FQMPLESFHSLQEDWKLEI;TAKEWGTTP;TPIAPGFA;VGSSPTPGEGVGKSFAGERLEN;VLLWELLTGEV 5 7.2 0.97788 0.047788 0 0 0 0 7.61375 0 0 0 0 0 0 0 0 0 0 A0A8C0LZB3 A0A8C0LZB3_CANLF VPS9 domain-containing protein ANKRD27 Canis lupus familiaris (Dog) (Canis familiaris) AAAVGDVDFCHP;ADSISQASSTSSFSSV;AQIHGIVL;CWWHCLQLQEQGCYLLHPS;DTEKWPLELLPFWSRF;FTRQFYFVPSG;HLPLERRRKSS;QDGTSPLHVAALHGRADLI;SAKDELGYCLTSIEAAIE 9 11.8 1.0031 -0.79673 0 0 6.80374 0 0 10.3726 9.47188 0 0 10.3631 0 0 9.74153 9.70096 0 A0A8C0LZB9 A0A8C0LZB9_CANLF Tubulin tyrosine ligase like 11 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] GCGRSSGNPADELRPPRPVT;LDQRDSGMCL;PFGRRLPCDIYW;SLNIHSGN;VEAFFYLA;VEAFFYLAQ 6 7.8 1.0033 -2.0651 0 0 0 0 0 0 0 12.5142 0 12.5094 0 0 0 0 0 A0A8C0LZC0 A0A8C0LZC0_CANLF F-box protein 38 FBXO38 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] AELEFPQFETLHLGYVDEFLLQSR;ATASTVGTSSSHSTASQ;EENDFRQDLQPGEQQFAAD;GYVDEFLLQSRMANADLVK;KRTADKSTSTSDPV;RSWMDTIANI;SNNDNDNNAQN;TYMPHVHI;VDGAPYSMISDFPWLRSLRAAE 9 11.6 1.0032 -1.9237 10.3709 11.0776 9.40305 0 0 0 10.4923 0 7.43863 9.60121 11.5402 9.96022 8.55773 8.3773 0 A0A8C0LZC3 A0A8C0LZC3_CANLF FAD/NAD(P)-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] VHQMMREQSI;VLGRNLPGGAWH 2 4.6 0.98932 -0.52041 0 0 0 0 0 0 0 10.6228 0 10.8397 0 0 0 0 0 A0A8C0LZD0 A0A8C0LZD0_CANLF Zinc finger and SCAN domain containing 4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ENLEHKLS;FIVHEEDCPHKGQCFL;NLEHKLSQGPAIQE;NNERTFICAECNKGFFQ;NSNSSARQELQNLYKLFHSWLQPE 5 16.7 1.0038 -0.83394 0 10.0331 0 0 7.53419 0 0 8.17023 8.44733 0 8.26651 9.41304 0 0 0 A0A8C0LZD1 A0A8C0LZD1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AAICLVLLLLLR;PPGAAICLVLLL 2 3.7 0.94064 0.10088 6.81031 6.68257 0 1.8577 0 0 0 7.58323 0 0 0 0 0 0 0 A0A8C0LZD6 A0A8C0LZD6_CANLF Tetratricopeptide repeat protein 7 N-terminal domain-containing protein TTC7B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] plasma membrane [GO:0005886] PRGPRPQLTEVR;YSLQATDASLRGMQEVLQR 2 4 0.98208 -0.25054 0 0 0 0 0 0 0 0 0 0 0 0 0 7.46385 0 A0A8C0LZE9 A0A8C0LZE9_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DAVPGSWPWQVSL;GDSGGPLVCQKDGA;LVGAASNC;SGGPLVCQKDGAWTLVGIVSWGS;VGAASNCGVPAIEP 5 20.2 0.98899 -0.52496 0 9.79093 0 0 0 0 9.78789 0 0 0 0 0 0 0 0 A0A8C0LZG3 A0A8C0LZG3_CANLF TRMT1-like protein TRMT1L Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; tRNA processing [GO:0008033] metal ion binding [GO:0046872]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]; tRNA binding [GO:0000049] TYTGGQSEGHVQSASEDTVAD;VLMHLRSFDFIHLDPFGT;VLVVVRVLR 3 6.9 0.98537 -0.44079 0 0 0 0 0 0 0 8.89367 0 10.4703 0 0 10.9805 0 0 A0A8C0LZH9 A0A8C0LZH9_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 8 ADAMTS8 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ERLQSFRPLPEPL;GVCGGKGN;LLLLLLLL;LLLLLLLLP;LLLLLLLP;PPLLLLLL;PPLLLLLLL;VLSMPHDD 8 4.5 1.0031 -2.149 6.37971 0 0 8.56643 8.6414 8.81336 0 0 0 0 0 0 0 8.61265 0 A0A8C0LZI2 A0A8C0LZI2_CANLF Aldehyde dehydrogenase domain-containing protein ALDH1A3 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" ALCCGNTIVVKPAE;IVCADADLDLAVECAHQGV;LEVEFTKIFIN;LLCLLTHPLGGPWW;RHEPIGVCGAITPWNFP;THLWGVTVPLLC;VECAHQGVFF;VVCFTRHE 8 16 1.0038 -2.0385 0 0 9.32713 9.51989 10.6448 9.50428 0 6.62807 8.0614 8.40599 0 0 0 6.1553 0 A0A8C0LZL0 A0A8C0LZL0_CANLF REST corepressor 1 RCOR1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEMYYWYNCIP;DNSIKMPEEEDEMYYWYN;PEEEDEMYYWYNCI;PNGNSSSNSWEEGSSGSSSD;PNNGQNKSLAAAAPN;TKTSVMDRH 6 12.6 0.99157 -0.54877 6.41757 8.90232 0 0 0 0 0 0 0 0 0 0 8.29623 9.15828 8.26379 A0A8C0LZL1 A0A8C0LZL1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IAVGIYLLLLGVVLLI;SRPQDCCWTCAEAC 2 21.6 0.98392 -0.23969 0 0 0 0 0 0 0 0 0 4.41237 0 0 0 0 0 A0A8C0LZL7 A0A8C0LZL7_CANLF Interferon lambda-4-like Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response to virus [GO:0051607]; positive regulation of immune response [GO:0050778] extracellular region [GO:0005576] cytokine activity [GO:0005125] DLRLVADS;DLRLVADSG;HEASVIFNLLRLLTRDLRL 3 14 0.43791 0.52631 0 12.5519 0 0 11.4672 0 0 0 0 0 0 0 0 0 0 A0A8C0LZN9 A0A8C0LZN9_CANLF Anaphase-promoting complex subunit 4-like WD40 domain-containing protein EML5 Canis lupus familiaris (Dog) (Canis familiaris) CVWKDHILCRIV;DSKNAVCVWDWKR;FDISWDLYQPNKLVSCGVKHIKFW;GVCAVDFSADGKRLA;GVIYNRQQN;IVVHERNKPFLIM;NVATGTQSFYQEH;RDRRCAIHDI;VGLDPEHTIT;VGLDSKNAVCVWDWKRGK;VHTHGIACLAFDL 11 6.9 1.0019 -1.7994 8.85487 0 9.02209 0 8.70615 9.30209 0 7.42719 10.4139 8.58331 0 0 11.464 9.24821 2.88419 A0A8C0LZQ9 A0A8C0LZQ9_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EAFHLYLVVIKVFNT;GVLLLSLLLLQ;ILTPLGLSTIY;LSTIYVFALFN;SEVWLAITILDI;SLFESLQGNRSE;TWMGLEAFHLYLVVIKV;VNTNISEDLL 8 14.5 1.0035 -1.616 0 12.049 0 0 0 0 0 10.2915 0 0 0 0 0 0 0 A0A8C0LZR8 A0A8C0LZR8_CANLF Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) PDGFRB Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell chemotaxis [GO:0060326]; positive regulation of smooth muscle cell migration [GO:0014911] cytoplasmic vesicle [GO:0031410]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407] AILALVVLTIISLIILI;DAVQFAELHR;DYLHRNKHTFLQ;FLTEITEITIPCRVTDPRL;IILIMLWQKKPRYE;LGACTKGGP;SLTGGTPY;VVWFKDNR 8 8.7 0.98959 -0.26592 0 0 0 0 0 0 0 10.2299 0 0 0 0 0 0 0 A0A8C0LZS1 A0A8C0LZS1_CANLF Taxilin beta TXLNB Canis lupus familiaris (Dog) (Canis familiaris) syntaxin binding [GO:0019905] PGQPPVADT;SGEPQSTPPGD;TEPPDNEDG 3 4.4 1.0041 -1.0809 0 0 6.9735 0 0 0 0 0 0 0 0 0 8.04396 0 0 A0A8C0LZS7 A0A8C0LZS7_CANLF Olfactory receptor family 10 subfamily D member 5 OR10D5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FYHFLGCTECFLYTVMAYDR;PVVLPLACADTS 2 10.3 0.95381 0.05044 0 0 0 0 0 0 0 0 0 0 0 8.76633 0 0 0 A0A8C0LZV1 A0A8C0LZV1_CANLF LIM zinc-binding domain-containing protein LHX6 Canis lupus familiaris (Dog) (Canis familiaris) forebrain neuron development [GO:0021884] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DAAEARRHDGPQPEGHP;EIFCKMDYFRERPHAGGG;FRERPHAGGG;GGGGGGGG;GGRGGGGG 5 15.5 1.004 -0.82209 0 0 0 0 0 0 0 0 10.1815 0 0 9.06356 0 0 0 A0A8C0LZX2 A0A8C0LZX2_CANLF Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) SLC39A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] zinc ion transmembrane transporter activity [GO:0005385] CGGAASVP;QRKKTVAASLPEGP 2 4.8 0.99439 -0.55926 0 0 0 0 0 0 0 0 0 11.6886 0 0 0 0 0 A0A8C0LZX7 A0A8C0LZX7_CANLF Olfactory receptor OR2B11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PQMLVNMGSTRKTI 1 4.4 0.9413 0.061072 0 0 10.1536 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LZY5 A0A8C0LZY5_CANLF "Neurolysin, mitochondrial (EC 3.4.24.16) (Microsomal endopeptidase) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)" Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] RSPLQAMSSYTVAGR;STSHVTAFLDDLR 2 3.5 0.85734 0.14625 8.38332 0 7.86777 0 0 0 0 0 8.98738 0 0 0 0 0 0 A0A8C0LZY8 A0A8C0LZY8_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FAERNPVEELTM;LLLLLLLE;RELLCRQQDPCL 3 2.7 0.99439 -0.5591 0 0 0 0 0 0 0 9.44083 0 0 0 0 0 0 0 A0A8C0LZY9 A0A8C0LZY9_CANLF MYCBP associated protein MYCBPAP Canis lupus familiaris (Dog) (Canis familiaris) AKQSPPKLIEKKRAKV;INLWKQQQEVLS;KFIIRKLKPKDPKRKV;VEEIPDLGSTKSPWEPDGL 4 6.7 0.81614 0.20122 0 6.57645 0 0 5.57243 0 10.7656 0 0 0 0 0 2.6427 10.3192 0 A0A8C0LZZ4 A0A8C0LZZ4_CANLF V-type proton ATPase subunit E 1 (V-type proton ATPase subunit e 1) (Vacuolar proton pump subunit E 1) Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; synaptic vesicle membrane [GO:0030672]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" EEVDVKADEEL;TQRLKMMEYYEKKER 2 13.8 0.98837 -0.22505 0 7.19061 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0LZZ9 A0A8C0LZZ9_CANLF Sialate O-acetylesterase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) sialate O-acetylesterase activity [GO:0001681] FEVRIVETTGVRPVLGVRI;WNAMIHPLHN 2 5 0.95422 0.04941 0 0 0 0 0 0 0 0 0 0 0 4.88996 0 0 0 A0A8C0M014 A0A8C0M014_CANLF Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] zinc ion transmembrane transporter activity [GO:0005385] ETHRHLGPHEHCGD;QRKKTVAASLPEGP 2 6.6 0.99094 -0.26791 0 0 0 0 0 0 0 0 0 0 0 9.02034 0 0 0 A0A8C0M016 A0A8C0M016_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AEEDEDDFDDTL;AEEDEDDFDDTLV;DERELEADDEPGRPGHNN;HVLVKNCAVEFNF;ISVKHLPSTEP;LTIEGFAYLWSGA;NRGGGSGG;RPLEMEQQQAYRPEV;SPPQYAQQWNQYYQ;SPQPPAEEDEDD;TVSSYSPPQYAQ 11 14.5 1.0026 -1.3754 0 11.3575 0 0 5.16261 9.658 9.17418 0 4.25308 9.12663 7.37051 0 0 0 9.33575 A0A8C0M021 A0A8C0M021_CANLF FAD-dependent oxidoreductase domain-containing protein 1 FOXRED1 Canis lupus familiaris (Dog) (Canis familiaris) AGIGKGPP;EFLRNINE;GVYFRREGLG;GYYDYNTFDQNGV;LVVERDHTYSRASTVLS;VVIVGGGV;YDTSYLPPEHSDV 7 16.1 0.99718 -3.8818 13.2489 0 0 0 0 0 9.91946 10.6903 0 0 0 7.77446 9.71162 8.42769 11.5382 A0A8C0M022 A0A8C0M022_CANLF Proline rich mitotic checkpoint control factor PRCC Canis lupus familiaris (Dog) (Canis familiaris) DEAEPEPEEEE;LAPAFPPPLL;QVTKQITQEEDDSDEEVAPE 3 8.6 0.99217 -0.18383 0 0 3.74136 11.676 0 0 0 0 0 0 0 0 0 8.30214 0 A0A8C0M033 A0A8C0M033_CANLF Growth arrest specific 7 GAS7 Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041]; neuron projection morphogenesis [GO:0048812] actin filament [GO:0005884]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin filament binding [GO:0051015] TERQRDLEMKTQQLE 1 3.7 0.98546 -0.24567 0 0 0 0 0 0 0 0 8.05859 0 0 0 0 0 0 A0A8C0M066 A0A8C0M066_CANLF CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) PGS1 Canis lupus familiaris (Dog) (Canis familiaris) cardiolipin biosynthetic process [GO:0032049] mitochondrion [GO:0005739] ATP binding [GO:0005524]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] IDEIVTET;TAGAGGRK 2 3.3 0.99007 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14.5911 A0A8C0M087 A0A8C0M087_CANLF Kallikrein 1 KLK1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] LFLPYPHPDITPVSLHIRVHPF;LTLPVVFTLSLCALSFHPP;SQPVLLPHPQ 3 14.2 0.93103 0.096493 0 0 7.5772 6.55494 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M088 A0A8C0M088_CANLF ATP synthase mitochondrial F1 complex assembly factor 2 ATPAF2 Canis lupus familiaris (Dog) (Canis familiaris) HVVQHIFRQPYPEEQ 1 12.6 0.98378 -0.24311 0 0 0 0 0 0 9.58346 0 0 0 0 0 0 0 0 A0A8C0M0B6 A0A8C0M0B6_CANLF Voltage-dependent calcium channel gamma-8 subunit CACNG8 Canis lupus familiaris (Dog) (Canis familiaris) "neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; postsynaptic density membrane [GO:0098839] channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245] AAAYGGAG;FGGLSFILA;GAGGGGGG;GGGGGGGA;GGGGGGGG;KAGGGAGGSGGSGPSAILRL 6 14 1.0025 -1.3862 0 0 9.97241 0 9.49791 9.58071 0 0 0 0 0 0 0 0 0 A0A8C0M0C0 A0A8C0M0C0_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] MVLGSDSLWGHL;RGTSVQSHPSSL;SGWGLVSDHKPG 3 10.1 0.8529 0.15132 0 0 0 0 0 0 0 7.22487 0 0 0 0 0 0 11.4151 A0A8C0M0C2 A0A8C0M0C2_CANLF NDRG family member 4 NDRG4 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] DMQEITKHFVVCHVDAP;YLKDRRLSGGAVPSASMT 2 8 0.98994 -0.21262 0 0 6.79416 0 0 0 0 0 0 0 0 8.58417 0 0 0 A0A8C0M0E6 A0A8C0M0E6_CANLF Discs large MAGUK scaffold protein 5 DLG5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] DLKALGFDMAEGVN;EALRSLDDTRKQKNDVSRE;GISLENGV;IDPLMEQDE;LEQLEEEN;LPGDSFYIRALYDRLAEVEHE;SEEMEALRQIKDT;VGPCGAAEAPL 8 5.5 0.99956 -2.8547 0 7.57524 11.413 0 0 0 0 8.92727 13.1162 0 0 9.07719 0 9.43233 0 A0A8C0M0E8 A0A8C0M0E8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MARK3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321] EEDELKPFVEPEL;GIPSRKSSGSAVGGKGI;IKRLPTEYERNG;VHSLEDIAPSHKYSNNTI 4 7.9 0.99305 -0.17615 0 0 0 0 0 0 0 0 0 0 0 5.64605 9.60516 0 0 A0A8C0M0H1 A0A8C0M0H1_CANLF Sulfatase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) sulfuric ester hydrolase activity [GO:0008484] AGLGARRVGRRRKGKQRREKL;LDQVTLPQKLQE;PTRRGFDT;QTFSGGSNWPLRGRKGTYWEGGVRG;TEFQAAPLLPFPGPG;VDYYTYDNC;VHITDWYPTLVGLAGG 7 13.2 1.0023 -0.65137 11.1374 0 0 8.32382 0 3.69744 9.65381 10.143 0 3.65157 0 0 0 8.72969 8.58976 A0A8C0M0J6 A0A8C0M0J6_CANLF LMBR1 domain containing 2 LMBRD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLTWILLPFMQSY;GRNMDDYED;PEPENKFIQYFYNPTVEWYWE;RPWFYRILAVVL;TIYNRCKHAAANSSP 5 10.1 1.0032 -0.88679 0 0 0 8.15234 7.90382 8.38275 0 10.1085 0 0 0 0 0 9.05137 0 A0A8C0M0K3 A0A8C0M0K3_CANLF TNF superfamily member 18 TNFSF18 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; T cell proliferation involved in immune response [GO:0002309]; tumor necrosis factor-mediated signaling pathway [GO:0033209] membrane [GO:0016020] identical protein binding [GO:0042802]; tumor necrosis factor receptor superfamily binding [GO:0032813] LDLIFNAEHQVLKNTTYWGILLLA;LSHSSPQGT 2 18.5 1.0023 -0.76291 0 0 0 0 0 0 0 0 0 0 0 10.6707 0 0 0 A0A8C0M0K6 A0A8C0M0K6_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin-protein transferase activity [GO:0004842] DAGEPVCICHPV;DSTRSRAPLDAYFQ;GPTCKLLTKS;MTYCDTLSCLVMSQP;SNSALVSLLSFYIE 5 8.9 1.004 -1.0545 0 9.6809 0 0 0 0 0 0 10.3672 0 0 0 0 8.32881 9.37799 A0A8C0M0N2 A0A8C0M0N2_CANLF Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) Canis lupus familiaris (Dog) (Canis familiaris) ammonium homeostasis [GO:0097272] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323] ammonium channel activity [GO:0008519] AGNGGDPP;EFRASVFGRN;RGYIRVGVENLINA 3 4.1 1.0038 -2.0302 0 0 0 6.36797 0 0 0 0 0 0 0 0 0 10.0319 6.01843 A0A8C0M0N6 A0A8C0M0N6_CANLF PPARG coactivator 1 alpha PPARGC1A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription coregulator activity [GO:0003712] EYQHERLKREEYRREYEKRESERAK;NSPCRDSVSPPKSLFAQ;PYSRRPRYDSYEEYQHERLKRE;RPRYDSYEEYQHERLKREEYRREYE;WDMCNQDSVWSD 5 9.5 0.99505 -0.15776 0 7.7324 0 0 10.3026 0 0 7.52317 7.56117 0 7.41049 6.08055 0 0 8.81558 A0A8C0M0P7 A0A8C0M0P7_CANLF DAGKc domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) kinase activity [GO:0016301] SEAVQGQVHPDYLWMVSGCMEPPA 1 6.2 0.97349 0.041303 6.79701 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M0Q9 A0A8C0M0Q9_CANLF VASt domain-containing protein GRAMD1A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] CFLLIFRLWQNA;DSQPDASSSQTV;IEKNSWSGIEDYFHHLERELAKAEK;IFRWETTISI;IPSALVLISIVLIVLIAL;PEAERLIVDYSC;PGASGPPA;PSALVLISIVLIVLIAL;TSLGPLDLLP 9 13.3 0.98764 -0.46861 0 0 9.73347 9.00155 8.82687 3.00263 10.7597 9.34607 0 0 0 0 4.67796 0 0 A0A8C0M0R1 A0A8C0M0R1_CANLF Cyclin-F Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] centriole [GO:0005814]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] LARLTHGQTQPWTT;NFEAAVKLGIAYLYNEGLS;VDRYLRRRLVPRYRLQLLGIAC;VLSLFEDEERKQQAQ;VYLSPEQHCC 5 10.2 0.98678 -0.39659 0 0 0 3.92029 0 0 7.61941 10.3827 0 0 0 0 0 7.81634 8.80365 A0A8C0M0R3 A0A8C0M0R3_CANLF Solute carrier family 45 member 2 SLC45A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824] EDKERGLHYHAF;EFLIYERGVEVGCWGLCINSV;FYKLLIKALIADPRRKRI;GRVLGSEFQVMFFFSAL;HLEIGRVLGSEFQV;LNLLADFGGGALIC;LVSYIGLKGLYF;YHGDPYSA 8 18.8 0.91707 0.1094 0 0 0 0 0 0 0 0 0 0 0 7.1641 5.52795 0 0 A0A8C0M0T3 A0A8C0M0T3_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metallopeptidase activity [GO:0008237] CHVECNNMLNDFDDGDCCDPE;GVSERESCDDPCRE;KVSGSLGEECDDGDLLSGDGC;LNHAFSRYNISWQL;STLSSKKV;SYTDDDCTD;VLNPAYYGMPGHTNIMIHEVGHVL 7 6.7 1.0018 -1.4691 0 0 10.4512 0 10.4762 8.19441 0 11.1808 0 0 0 0 0 10.4531 0 A0A8C0M0T9 A0A8C0M0T9_CANLF Glutamate receptor GRIN2C Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] glutamate-gated receptor activity [GO:0004970]; inorganic cation transmembrane transporter activity [GO:0022890] AHLPLCWGAVCPP;LDVLTLELGPGG;LETVWLSG;PSPRPSPEPSPTGWG;SREEAEVLFAEAAQA 5 5.2 0.98873 0.03285 11.1328 0 3.30996 9.06331 0 0 11.0382 9.83404 11.1007 11.1055 11.5844 11.2754 0 10.5179 0 A0A8C0M0U8 A0A8C0M0U8_CANLF Glutamate receptor GRIN2C Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] postsynaptic membrane [GO:0045211] transmitter-gated monoatomic ion channel activity [GO:0022824] LDVLTLELGPGG;LETVWLSG;SREEAEVLFAEAAQA;VGAPHPPG 4 4.9 0.99006 -0.26592 3.78691 0 0 0 0 0 3.67322 0 0 16.6968 0 16.7564 16.9266 16.9772 0 A0A8C0M0V6 A0A8C0M0V6_CANLF Coiled-coil serine rich protein 2 CCSER2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule bundle formation [GO:0001578] microtubule cytoskeleton [GO:0015630] microtubule binding [GO:0008017] EDDDLMLDVDLPED;KPSVSNSLVPPPVSESSPSRTPTC;LPLFKPSVSNS;NLISPDTDYR;PWRRIPPQVLQPS;TDEWIDISV 6 7.4 1.0022 -1.267 0 13.9832 0 0 9.07323 0 0 0 0 0 0 0 12.4757 0 0 A0A8C0M0W0 A0A8C0M0W0_CANLF Zinc finger and BTB domain containing 49 ZBTB49 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EFDGHATS;ELPFRQPSYYYKLRNFYSKQ;EQFNCMNEMERPEEPA;LVSSEQFNCMNE;TLDGNCAELPFRQPSY;VEQPPGVS 6 8.2 1.0021 -1.4067 8.52583 8.22521 0 8.77778 0 7.36982 0 13.641 0 0 0 9.07093 7.78738 0 0 A0A8C0M0W7 A0A8C0M0W7_CANLF ABC transporter domain-containing protein ABCA8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EITTNHSVMEELM;IDNFIHSLRQQ;IHLDYDVNSN;KKVAIRNVSFCV;VLIKKPFLTGL 5 3.6 1.0045 -1.044 0 0 0 0 0 0 0 7.33727 0 0 0 0 0 0 9.26852 A0A8C0M0X5 A0A8C0M0X5_CANLF Peptidase M12B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CTAGSCLG;DQNTQVSSSFCNAR;LVFEVLMQGKNPGIAWKYAL;TIAHESGHNFGMIHDGEG;VEVDSGGSYISHDI 5 6.4 1.0024 -1.7501 0 0 10.218 0 0 9.87656 10.3507 0 10.328 11.5953 0 0 0 8.32454 0 A0A8C0M0Z5 A0A8C0M0Z5_CANLF Kinesin-like protein KIF22 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ILKKKGRKRKL;SLDASEPEEKAED 2 3.6 0.92271 0.095327 0 0 0 0 0 0 0 0 0 0 0 3.2814 0 9.1716 0 A0A8C0M104 A0A8C0M104_CANLF NAD(+) kinase (EC 2.7.1.23) NADK Canis lupus familiaris (Dog) (Canis familiaris) NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] NAD+ kinase activity [GO:0003951] FCTFREDYDD;GKKMTMPNGISENGV;PIVVPAGVELKIML;VLQNPQTIMHIQD;WNVRKKQAHFTEEEE 5 14.8 1.0018 -0.96042 0 0 10.3579 0 3.99077 0 11.4567 0 6.89482 0 10.1732 0 0 0 0 A0A8C0M106 A0A8C0M106_CANLF Elongator complex protein 2 ELP2 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] IVSAASDSTVRIWS;PSILTEPPTEDHLLQ;SNSKTLLA;SSLKKRIVV;VETSQRLY;VTNPREWTP 6 8.3 1.0025 -2.1765 11.1406 0 0 0 9.35614 0 0 11.6019 0 0 12.216 12.0885 0 12.5217 13.149 A0A8C0M118 A0A8C0M118_CANLF Tetratricopeptide repeat domain 22 TTC22 Canis lupus familiaris (Dog) (Canis familiaris) HPSPTLSSPP;QKRLPAFNRTLALLRQVL;TYLDIGQVYYY 3 5.7 0.98763 -0.23437 0 0 6.47955 0 0 0 0 0 8.82556 0 0 0 0 0 0 A0A8C0M123 A0A8C0M123_CANLF Target of myb1 like 2 membrane trafficking protein Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] EDWTLNMEIC;EDWTLNMEICDIINETEE;PYSSAPQAPALSVTGPIMAN;VGTCPSSFPSPAPVL 4 7.7 0.98925 -0.5085 0 0 0 0 0 0 0 0 12.2112 9.37447 0 0 0 0 0 A0A8C0M131 A0A8C0M131_CANLF superoxide dismutase (EC 1.15.1.1) (Nitrite reductase CYGB) (Pseudoperoxidase CYGB) (Superoxide dismutase CYGB) Canis lupus familiaris (Dog) (Canis familiaris) heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] VGSPPRAR 1 2 1.0039 -1.1044 0 0 0 0 0 0 5.39527 6.61243 0 0 0 0 0 0 0 A0A8C0M132 A0A8C0M132_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;KKESYRPISL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 6.9 0.99986 -0.61146 0 0 0 0 0 0 0 0 0 7.75869 0 0 0 0 0 A0A8C0M176 A0A8C0M176_CANLF WD repeat domain 20 WDR20 Canis lupus familiaris (Dog) (Canis familiaris) DLQRHAPGPT;GGDGGGGG;GGGDGGGG;GGGGDGGG;GGGGGDGG;GGGGGGDGGG;GGGGGGGD;GWRGAAAPSF;LCPRMEDVPLLE;SRGGGGGGG 10 6.5 1.0022 -1.1342 0 14.062 0 0 0 0 0 0 0 0 0 0 9.18207 0 0 A0A8C0M190 A0A8C0M190_CANLF "NADPH:adrenodoxin oxidoreductase, mitochondrial (EC 1.18.1.6)" Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] DSEDLPCGLVLSSVGYKSRPIDP;GKGAGKPR;GVIATTMTDSF;VVLLAPDL 4 11 1.0041 -1.1044 0 0 6.74927 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M192 A0A8C0M192_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] LGHEGGSCHVTLWCVHLES;WHPACRQAARTEDKNKMH 2 4.4 0.95037 0.049892 0 0 0 0 0 0 0 0 0 0 0 4.41859 0 0 0 A0A8C0M193 A0A8C0M193_CANLF Aldehyde dehydrogenase domain-containing protein ALDH1A3 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AAGGSGGAW;IVCADADLDLAVECAHQGV;LLCLLTHPLGGPWW;THLWGVTVPLLC;VECAHQGVFF 5 11 1.0044 -0.80421 0 0 0 0 0 0 0 6.48219 0 9.36332 0 0 0 8.07387 8.96287 A0A8C0M194 A0A8C0M194_CANLF Rhodanese domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] AGILSTAR;DLKVPRWDFQ;IQNLQEDWDHFEPL;KRRKDDVE;SLLRRMPELDTLEIM 5 6.7 1.0031 -1.733 0 8.4882 9.36181 0 9.7178 0 0 0 0 0 0 0 12.0866 0 0 A0A8C0M1B0 A0A8C0M1B0_CANLF "Troponin I1, slow skeletal type" TNNI1 Canis lupus familiaris (Dog) (Canis familiaris) troponin complex [GO:0005861] actin binding [GO:0003779] GAGHGGRK;VEVVDEERYD 2 9 0.99047 -0.26592 0 10.5882 0 0 0 0 0 10.5251 10.5717 0 0 10.802 0 0 10.0845 A0A8C0M1B5 A0A8C0M1B5_CANLF RCC1 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) DTKTIPREAS;EDGAPAPFIA;EDGFEVRRTAKGE;RALAPELRARRLEL;YGQLGHKDTTSLDRPCR 5 16.6 1.0035 -1.5944 9.68392 10.6397 0 0 0 9.25576 0 0 0 0 0 0 0 0 0 A0A8C0M1D7 A0A8C0M1D7_CANLF "Endoplasmic reticulum membrane sensor NFE2L1 (Nuclear factor erythroid 2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)" Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; regulation of transcription by RNA polymerase II [GO:0006357] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; lipid binding [GO:0008289]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GCSQDFSLFSPEA;LGGCSQDFSLFSPEAE;NLPVEEFNELLSKYQ;VLSPQACVGLVMLDI 4 7.1 0.99757 -0.089517 0 0 0 0 0 0 0 0 0 0 0 0 0 14.279 0 A0A8C0M1E0 A0A8C0M1E0_CANLF Glutamate rich 4 Canis lupus familiaris (Dog) (Canis familiaris) GLLWLWEELGHLRQV 1 11.2 0.94996 0.05389 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.46791 A0A8C0M1F0 A0A8C0M1F0_CANLF RNA helicase (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) DHX9 Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to tumor necrosis factor [GO:0071356]; CRD-mediated mRNA stabilization [GO:0070934]; DNA-templated transcription termination [GO:0006353]; DNA-templated viral transcription [GO:0039695]; G-quadruplex DNA unwinding [GO:0044806]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; positive regulation of viral translation [GO:1904973]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of mRNA processing [GO:0050684]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501]" actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; perichromatin fibrils [GO:0005726]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA replication origin binding [GO:0003688]; double-stranded RNA binding [GO:0003725]; importin-alpha family protein binding [GO:0061676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; triplex DNA binding [GO:0045142] DDANCNLICG;DEIHERDINTDFL;EVYGRTYPVQEYFLE;GGSSYGGG;GYAGGSNS;VVIIRGATGCGKT;YPVQEYFLEDCI 7 5.5 1.0003 -2.8172 0 0 0 14.4012 14.449 14.5182 9.38519 7.21597 9.52939 0 0 0 12.8234 12.7735 10.8189 A0A8C0M1G1 A0A8C0M1G1_CANLF MORN repeat containing 1 Canis lupus familiaris (Dog) (Canis familiaris) GVYVYPNSFFR 1 3.2 0.98717 -0.23498 0 0 0 0 0 0 11.1344 0 0 0 0 0 0 0 0 A0A8C0M1H1 A0A8C0M1H1_CANLF TBC1 domain family member 24 TBC1D24 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; presynapse [GO:0098793] GDLVNKYCQAA;RPDLSLPQVE;RWLFGELPLS 3 4.9 0.99312 -0.048306 0 0 0 0 0 0 0 0 0 0 0 0 11.3113 0 11.946 A0A8C0M1H4 A0A8C0M1H4_CANLF Spermatogenesis associated 7 SPATA7 Canis lupus familiaris (Dog) (Canis familiaris) ADQQRREKLKK;STELSPALQ 2 4.8 0.99472 -0.077773 0 0 0 0 0 0 0 0 0 0 0 0 9.36194 0 0 A0A8C0M1H5 A0A8C0M1H5_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] FCERCHNARQLCRPQ;LVDDYFELVQH;VTLKDSGPEIRAVP 3 7.5 0.98665 -0.40986 0 12.9767 0 0 0 10.7535 8.92244 0 0 0 0 0 0 0 0 A0A8C0M1J3 A0A8C0M1J3_CANLF NLR family pyrin domain containing 13 Canis lupus familiaris (Dog) (Canis familiaris) EEMRVLLNNALVDRNFYWNQMALFF;EYFSEKQMW;HEEMRVLLNNALV;IFKTLRHSACNLQYLCLEKCNLS;LLSYLMGLDQSQLEEFKLCLQSPQL;RILFYLLKKEL;SLYVHFFSSL 7 10.3 1.0025 -1.2006 7.15947 0 0 0 0 0 0 10.8415 10.418 0 0 0 7.67744 9.85588 5.68218 A0A8C0M1J6 A0A8C0M1J6_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] FHLEYLFIEGN;IQNLYRWDPDLSSG;STDRRDFF;VIRDDAFAGLFHLEYLF 4 8.3 0.94322 0.0611 0 0 0 8.8438 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M1K0 A0A8C0M1K0_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2Z Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] GVMEKSFLEYYDFYE 1 5.9 0.9514 0.053888 0 0 0 6.56615 0 0 0 0 0 0 0 0 0 6.48802 0 A0A8C0M1K3 A0A8C0M1K3_CANLF Cellular tumor antigen p53 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262] centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] QRVMEAVH;RSSSNASTISIGSSGELQ;VYYMHVRGREN 3 6.8 1.0037 -1.0561 0 0 0 0 0 0 0 0 9.49951 0 0 9.91367 0 0 0 A0A8C0M1L0 A0A8C0M1L0_CANLF Leucine zipper protein 1 Canis lupus familiaris (Dog) (Canis familiaris) AEFTSYKETASS;EKQKSTSKPGPNK;QPVAVVME;SEDRLDKTEQSLVSEL;SFPNSKPPLL;TEDRFAPGSSQ 6 6.8 1.0031 -1.4987 0 0 0 0 0 8.16249 0 10.0547 10.0326 0 0 11.7244 0 8.02348 5.78521 A0A8C0M1M0 A0A8C0M1M0_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] AELTSNVLKTGV;CKEEAYQMTHDA;DAKGQVALLSRTN;DSYYGLLGTLPCQEPQSHICSL;GDPHQQIYTFR;GIKSFGLDRIIDIWIL;LSRCSAESG;PRSPPVRRFKRKHLT;TEVKEEPSVWPG;VGRKYQLKKKLNLF 10 12 1.0044 -1.0967 0 0 0 0 0 4.82568 7.83801 13.212 8.92006 0 0 0 9.12099 0 13.0849 A0A8C0M1Q2 A0A8C0M1Q2_CANLF Collagen type I alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; metal ion binding [GO:0046872] AGPPGRDGIPGQPGLPG;LPFTPESHW;NCPGAQVPPGECCPVCPDGEASPTD;SPGADGPA;VFIFDQLNMTK;VGAKGEAGPQGARGSEGP;VGPPGPSG 7 6.3 0.99937 -2.9201 8.39245 3.23364 0 0 0 8.18968 10.908 0 0 11.8087 0 9.19155 3.53132 0 3.98896 A0A8C0M1Q5 A0A8C0M1Q5_CANLF RPTOR independent companion of MTOR complex 2 RICTOR Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; TORC2 signaling [GO:0038203] TORC2 complex [GO:0031932] protein serine/threonine kinase activator activity [GO:0043539] DTDCGSMS;FHLLRQQMSLTEI;IQELFQDVQFLQ;LSHSEALASPAKDVLFTDT;NYLALILSAF;RLQRPHVYL;STELLLGV;SVRHSRKHLWPVVP;YRKPIDGDNYVRRSNQ 9 6.7 1.0012 -2.6974 8.67885 9.38741 0 0 0 9.87174 8.64638 0 0 9.4844 4.34511 7.75995 0 0 8.67052 A0A8C0M1Q8 A0A8C0M1Q8_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) LOC100688904 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] GVIWKYNPSHWPKDVKLAAN;MLFDFSMKKWQ;VGWIDHILQTGGAA 3 8.6 0.97878 0.035491 0 0 0 7.65621 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M1Q9 A0A8C0M1Q9_CANLF Protein kinase domain-containing protein VRK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] QCSRWMCPSGLS 1 2.6 0.94645 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.08066 A0A8C0M1V0 A0A8C0M1V0_CANLF Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translational initiation [GO:0002183] cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; guanyl-nucleotide exchange factor complex [GO:0032045] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] KMHNRICIPSQD;KQCRTFLLAIL 2 20.7 0.98919 -0.2166 10.3993 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M1V9 A0A8C0M1V9_CANLF Regulator of G protein signaling 14 RGS14 Canis lupus familiaris (Dog) (Canis familiaris) regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165] G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; microtubule binding [GO:0008017] TASLALAR 1 1.4 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 0 4.10559 0 0 0 A0A8C0M1W8 A0A8C0M1W8_CANLF Matrix remodeling associated 7 JMJD6 Canis lupus familiaris (Dog) (Canis familiaris) AGGHSGGR;MTKEELEEEQRVQKE 2 6.1 0.98924 -0.20385 14.5791 0 0 0 0 0 0 0 0 0 8.32463 0 0 0 0 A0A8C0M1X2 A0A8C0M1X2_CANLF Nucleolar protein 4 NOL4 Canis lupus familiaris (Dog) (Canis familiaris) GAEDLSLNRGDEDEDEHDEHDDSE;GGGGCAKQ;KAISESYAFLPREAVTRFLM;QLLDNSKENDMNYLQNKLK;SPAHSYSSYESGKNESVD 5 14.2 1.0015 -0.91503 0 0 10.0794 0 0 0 8.87983 0 0 0 0 7.56178 0 0 3.87224 A0A8C0M1Y3 A0A8C0M1Y3_CANLF Proprotein convertase subtilisin/kexin type 6 PCSK6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EDEEDYTGMCHP;GYFGDTAA;SNMWYMHC;VPEDEEDYTGMCHPEC 4 3.3 1.0023 -1.0178 0 0 0 0 0 0 0 0 9.03634 9.04718 0 0 0 0 0 A0A8C0M1Z2 A0A8C0M1Z2_CANLF Milk fat globule EGF and factor V/VIII domain containing Canis lupus familiaris (Dog) (Canis familiaris) WTEYKDQGAIEGKAH 1 3.4 0.95184 0.0539 0 0 0 0 0 0 0 0 9.38939 0 0 0 0 0 0 A0A8C0M1Z6 A0A8C0M1Z6_CANLF Protein regulator of cytokinesis 1 PRC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule binding [GO:0008017] CVQGHPQHSSSPFIQVSH;GSKAKVKKAL;YYDEDYTENLLQLH;YYDEDYTENLLQLHD 4 6.9 0.99088 -0.51475 0 10.2019 8.49121 0 0 0 0 0 5.50646 9.41079 9.44435 9.85208 8.46622 11.7934 0 A0A8C0M1Z7 A0A8C0M1Z7_CANLF "ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758]; metal ion binding [GO:0046872] EAMMVDQANHIEAIWHDE 1 5.1 0.97609 0.048313 0 0 8.99098 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M204 A0A8C0M204_CANLF Niban apoptosis regulator 1 Canis lupus familiaris (Dog) (Canis familiaris) DCTSGAHHTCPSESPVSVEETL;KTAVAIEKVKLRVLKQYD;TEEIKAASVHECQWVVENAPNI 3 6.6 0.87166 0.14336 0 0 0 0 0 0 0 0 6.81493 0 5.87268 0 0 0 7.96976 A0A8C0M215 A0A8C0M215_CANLF G-protein coupled receptors family 2 profile 1 domain-containing protein GRN Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] FECPNSSTCCTMLDGSWGC;GCCPAPEAVCCSDHQH;HRQTMWTLVS;LDGSWGCCPMPQASCCEDKVHCC;PEAVCCSDHQHCCPHG;PGYSCLLTILGTSSC;TENDVPCDNVT;VGQTCCPSLSGGWACCQLPH 8 18.1 0.9917 -0.54509 0 9.41155 6.68103 0 6.88007 0 7.18805 0 0 5.96019 8.35257 0 0 0 0 A0A8C0M221 A0A8C0M221_CANLF Ig-like domain-containing protein NTM Canis lupus familiaris (Dog) (Canis familiaris) KESLAYFSRFVHRLGI;NVSEHDYGNYTC;QEVKTTALTPWKGP;YGNYTCVASNKLGHTNASITLFE;YTCVASNKLG 5 16.4 0.99803 -0.60585 0 0 0 0 0 8.99529 0 0 0 9.87295 3.3251 9.40146 0 0 0 A0A8C0M223 A0A8C0M223_CANLF Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Redox-regulatory protein FAM213A) PRXL2A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ARNGGFSGNLEGE;EPQGFWVARSCPWWERESLRP;FVRLGVWYN 3 13.6 1.0018 -1.3654 9.80929 0 0 0 0 0 0 6.95582 0 0 0 0 0 0 0 A0A8C0M224 A0A8C0M224_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EAFTHKDNIPA;KYGAGYYMTL;LKLLLWKNFILKKRKP;MTLGRNLKLLLWKNFILKKRK;MTLGRNLKLLLWKNFILKKRKPLV;NLKLLLWKNFILKKRKPLVTML;PDAPSKPLEQDVGQ;TLGRNLKLLLWKNFILKKRKP;TLTAGSAA;VFLHYKEEA;VGDPDKASESKFIQE 11 5.2 1.0031 -2.3053 0 9.92901 0 5.18614 0 0 10.697 0 0 11.5968 0 5.71987 5.60937 0 13.8856 A0A8C0M227 A0A8C0M227_CANLF DMAP1-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAVDVRAWPP;CCCTCCCTAAP;CCCTCCCTAAPGSAA;CCCTCCCTCCCT;CCCTCCCTCCCTAA;CCCTCCCTCCCTAAP;CCCTCCCTCCCTAAPGS;CCCTCCCTCCCTC;CCCTCCCTCCCTCCC;CCCTCCCTCCCTCCCTAA;CCCTCCCTCCCTCCCTAAP;CCCTCCCTCCCTCCCTAAPGS;CCCTCCCTCCCTCCCTAAPGSAAR;CCTCCCTCCCT;CCTCCCTCCCTA;CCTCCCTCCCTCCC;CCTCCCTCCCTCCCTA;CCTCCCTCCCTCCCTAA;CCTCCCTCCCTCCCTAAPGS;CCTCCCTCCCTCCCTAAPGSA;CCTYTCCC;CCTYTCCCT;CCTYTCCCTCC;CCTYTCCCTCCCTCCC;CTCCCTCCCTAA;CTCCCTCCCTC;CTCCCTCCCTCCCT;CTCCCTCCCTCCCTA;CTCCCTCCCTCCCTAA;CTCCCTCCCTCCCTAAP;CTCCCTCCCTCCCTAAPG;CTYTCCCTCCC;CTYTCCCTCCCTC;DPVVLCCTYTCCCTCCCTC;GAPVSEYPFV;LCCTYTCCCTCCC;LCCTYTCCCTCCCTCCC;LCCTYTCCCTCCCTCCCTC;PVVLCCTYTCCCTCCCTCCC;TCCCTCCCT;TCCCTCCCTA;TCCCTCCCTCC;TCCCTCCCTCCCT;TCCCTCCCTCCCTAA;TCCCTCCCTCCCTAAPGS;TCCCTCCCTCCCTAAPGSA;TCCCTCCCTCCCTC;TCCCTCCCTCCCTCC;TCCCTCCCTCCCTCCCT;TCCCTCCCTCCCTCCCTAAP;TCCCTCCCTCCCTCCCTAAPGSAA;TYTCCCTCCCT;TYTCCCTCCCTCC;TYTCCCTCCCTCCC;TYTCCCTCCCTCCCT;TYTCCCTCCCTCCCTCC;TYTCCCTCCCTCCCTCCC;TYTCCCTCCCTCCCTCCCT;TYTCCCTCCCTCCCTCCCTA;TYTCCCTCCCTCCCTCCCTAA;VLCCTYTCCCTCCC;VLCCTYTCCCTCCCTCC;VLCCTYTCCCTCCCTCCC;VLCCTYTCCCTCCCTCCCT;VLCCTYTCCCTCCCTCCCTC;VLCCTYTCCCTCCCTCCCTCC;VPMPSKRR;VVLCCTYTCCCTCCCTCCC;YTCCCTCCC;YTCCCTCCCTC;YTCCCTCCCTCCCTCC;YTCCCTCCCTCCCTCCC;YTCCCTCCCTCCCTCCCTA;YTCCCTCCCTCCCTCCCTAA;YTCCCTCCCTCCCTCCCTAAP 75 3.4 0.99673 -5.3444 9.64418 11.0153 10.0741 8.68902 10.5455 9.44601 9.40943 10.6595 11.0406 7.12608 9.78087 9.7226 10.6451 10.6108 11.0457 A0A8C0M257 A0A8C0M257_CANLF Kv channel-interacting protein 4 KCNIP4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] cytoplasm [GO:0005737]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459] KMDKNKDGVVTIDEFIE;PPSLRKRILRPWRAPPPA;WAPGPGGG 3 7.8 0.97634 0.048313 5.13623 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M280 A0A8C0M280_CANLF NHS like 1 Canis lupus familiaris (Dog) (Canis familiaris) AHGALGTARGC;DNFKALLLK;ELRHFENVI;GFRQPCNKEEGGR;LCDDYQDEDEETDQ;LKSRDHLLSRHT;PNVYSLCGATP;SPLCDDYQDEDEETDQKCSVSS;SRKPPPISKKPKLFLVVPPPQRDLT;VISPACVVSPHA 10 7.9 0.94921 0.05044 0 0 0 9.6333 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M282 A0A8C0M282_CANLF CEP295 N-terminal like Canis lupus familiaris (Dog) (Canis familiaris) EQRRACLASLTSYSSQD;GVDVGPRGECAWPVPAEARQTAS 2 7.6 0.93729 0.092638 0 0 10.2639 0 0 0 9.62084 0 0 0 0 0 0 0 0 A0A8C0M290 A0A8C0M290_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CLPAANASFPNGLQ;HVAPSGEVVSLL;LGLILLLPLGLT 3 12 0.99384 -0.12066 0 0 4.31354 0 10.6172 6.88203 0 0 0 0 0 0 0 0 0 A0A8C0M2A8 A0A8C0M2A8_CANLF S-adenosylmethionine synthase (EC 2.5.1.6) MAT1A Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478] AKYLDEDTIYHLQPS;FPSDHHLTGPLWPP;PPVVFPSDHHLTGP;SYAIGVAEPLSI 4 10.5 1.003 -0.78132 9.87061 0 0 0 0 0 0 0 0 0 0 0 0 0 9.84867 A0A8C0M2B8 A0A8C0M2B8_CANLF cGMP-dependent protein kinase interacting domain-containing protein PPP1R12B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] stress fiber [GO:0001725] phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] ELNVQDYDGWTPLHAAAHW;EMEKRERRALERKMSEMEEEMKVLT;FLRFYSFTCKRRRPGP;ILAEALCDMDVRNKLG;VNPRRRLLRARLKAPGRRRRWRG 5 8.8 0.98806 -0.342 0 8.11499 0 10.9278 0 0 0 5.44632 0 0 0 6.05302 0 0 10.266 A0A8C0M2E3 A0A8C0M2E3_CANLF RRM domain-containing protein PPARGC1B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] DEDPSCPRLPSRD;EDEEEEEDEKDEEEEEE;EDEEEEEDEKDEEEEEEEWGRKRP;EEDEEEEEDEKDEEEEEEEWGRKRP;GELQWCPENSETEPSQYSP;LDEELSSFFL;TAGLTPPTTPPYKPTEED 7 8.3 0.9896 -0.51781 10.7427 8.75512 0 0 0 4.33178 0 5.44215 0 9.84417 0 0 11.5607 0 0 A0A8C0M2F8 A0A8C0M2F8_CANLF Myosin heavy chain 14 MYH14 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAARGYLARRAFQKRQ;EVEETRSSREEI;IAALESKLAQAEEQLEQESR;IVEMYRGK;LFCVVINPYKQL;VGANIETYLLEK 6 4 0.99661 -0.57905 0 0 0 0 0 5.55833 0 0 0 0 11.7226 6.50638 6.59435 0 0 A0A8C0M2G0 A0A8C0M2G0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGA;EVQLVESGGDLVKPGAS;EVQLVESGGDLVKPGASL;EVQLVESGGDLVKPGASLRL;GASLRLSCVASGF;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGA;QLVESGGDLVKPG;SGGDLVKPG;VESGGDLVKPG;VQLVESGGDLVKPG;VRQAPGKGLQ 21 34.6 0 28.777 13.866 13.6881 13.8493 12.6268 12.8686 13.0786 14.1356 14.095 14.1568 14.0711 13.7149 13.464 13.3525 13.0709 13.5863 A0A8C0M2G3 A0A8C0M2G3_CANLF Protein tyrosine phosphatase domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] protein tyrosine phosphatase activity [GO:0004725] EQAIKGVYSS;HAVTLAQYLIRQ;TVVPNPALE;VHCHAGLGRTGVLIA 4 6.2 1.0029 -0.7329 0 0 0 0 8.68731 6.15753 0 0 0 0 0 0 0 0 0 A0A8C0M2G7 A0A8C0M2G7_CANLF LIM interaction domain-containing protein LDB2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] LIM domain binding [GO:0030274] EDSDNLWWDAFATEFFED;RLITRLENTQ;TIRQYRELV 3 9.9 0.97658 0.048313 0 0 11.0497 0 0 0 0 0 10.3197 0 0 0 0 0 0 A0A8C0M2G8 A0A8C0M2G8_CANLF Synaptonemal complex central element protein 1 like Canis lupus familiaris (Dog) (Canis familiaris) synaptonemal complex assembly [GO:0007130] synaptonemal complex [GO:0000795] SASEYHVLWGSEW;SEWGACLFL 2 6.1 0.86519 0.18512 6.75409 0 0 0 9.66798 0 0 10.2947 0 0 0 0 0 0 0 A0A8C0M2H3 A0A8C0M2H3_CANLF G-protein coupled receptors family 3 profile domain-containing protein GPRC5C Canis lupus familiaris (Dog) (Canis familiaris) extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295] EAVAGAGV;VTASPCAI 2 3.8 1.0034 -2.2088 0 0 8.45483 0 0 0 0 0 0 0 8.06507 0 0 0 8.6561 A0A8C0M2H8 A0A8C0M2H8_CANLF Septin 9 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent cytokinesis [GO:0061640] cell division site [GO:0032153]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] PMSQLQSRLEPKPQPTVA;QTLENSEHTPMSQLQSRLEPKPQP;VPAAPTAD;VQEGCVQEGQCAGGP 4 4.3 0.95242 0.053885 0 0 0 6.69265 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M2K3 A0A8C0M2K3_CANLF Tektin Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317] microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; outer acrosomal membrane [GO:0002081] GVELVDSQVPDERAASAK 1 3.9 0.98789 -0.22855 0 0 0 0 0 8.97473 0 0 0 0 0 0 0 0 0 A0A8C0M2L9 A0A8C0M2L9_CANLF Estradiol 17-beta-dehydrogenase 1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" CNAGRGLLGPLEAHAAGAVESVLD;EVGAGRGP;GPALLQHRALP;LVPTSHWDLRQ;PGPALLQHRAL;TGSMGGLMGLPFNAVYCASK;TVVLITGCSSGI 7 18.9 1.0033 -1.6556 10.0358 0 0 0 0 0 0 10.4118 0 8.86706 10.2871 9.56487 0 0 8.53547 A0A8C0M2M1 A0A8C0M2M1_CANLF Actin interacting protein 3-like C-terminal domain-containing protein SRCIN1 Canis lupus familiaris (Dog) (Canis familiaris) DIQDRSIIK;EAGPRDPGGRGEPDPERSSPPM;EPLYAAFP;GPTWKAAPSP;GVTDMLAQIRRQ;KAGGMVLVKG;LAGKAGGM;PDGTQEPPTAETHPEET;RGSPVRQSFRKDSG;RSPREEAGPRDPGGRGEPDPERSS;TQYSAKDINRLLEETQ 11 8.4 1.0028 -2.1639 0 8.57826 0 11.1678 0 12.9625 0 14.2294 8.81529 0 13.6295 0 0 0 0 A0A8C0M2P3 A0A8C0M2P3_CANLF Zinc finger protein 667 ZNF667 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] TSLILHERS 1 1.6 0.98378 -0.25453 0 10.0773 0 0 0 0 0 0 0 9.76383 10.4947 0 0 10.7004 0 A0A8C0M2T0 A0A8C0M2T0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FHERMQLSTDGKNLTILTVQRED;LHVHRSDPTFL;PYECEVWNWGSRARSK 3 9.9 0.99581 -0.086166 0 0 0 0 0 0 0 0 0 0 5.44467 5.74333 11.233 0 0 A0A8C0M2T2 A0A8C0M2T2_CANLF Cytoplasmic polyadenylation element binding protein 4 CPEB4 NSG2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-UTR binding [GO:0003730]; translation regulator activity [GO:0045182] CGGKFAPFFCANVTCLQYYCEYCWA;IFVGGVPRPL;SIKGQSSLFPME;VCYAGIDTDPELK;VGGVPRPLRAVELAMI 5 9.7 0.98453 -0.24006 0 0 0 0 0 0 7.48583 9.7488 0 0 0 0 0 0 0 A0A8C0M2T3 A0A8C0M2T3_CANLF ZFP28 zinc finger protein ZFP28 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GQRPYECIECGK;HLDISEERVHN;HLDISEERVHNRD;LNQHRRIHTGEKP;VGQETQFRQ;VTMGPENRVMPS 6 6.8 0.99224 -0.19407 0 10.6854 7.75355 7.1234 0 0 11.6611 10.0551 9.84326 0 3.79992 7.4149 0 10.3337 4.25467 A0A8C0M2U0 A0A8C0M2U0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein serine/threonine kinase activity [GO:0004674] AIAGAEDM;FLDPIWLSECLQRIF;GTPLMEQYV;IEDLNISN;IPWGLINLRKLNLSKNHLGELP;KKSGGIKI;LVWSLDVKEH;MKLSCQLKVQNS;SKNALESLPDKMAVF;VVGTHLDLIETK 10 6 0.99766 -3.7477 0 0 8.45479 0 10.6673 0 3.92666 0 0 0 10.9298 0 10.6587 8.99712 10.5948 A0A8C0M2U8 A0A8C0M2U8_CANLF Myosin heavy chain 10 MYH10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AWRARITCLSSC;EEEEERNQILQNEKKKMQ;EKANARMKQLKRQ;ETRSHEAQIQ;HIFYQLLSGAGEHL;QQEEEEEARKNLEKQ;RDYVQKAQTKEQADFAVEALA;TKEEFERQNKQLRADMEDLISS;VGANIETYLLEK 9 6.4 0.98704 -0.49846 0 0 0 0 8.33266 8.09851 8.85449 6.27023 0 0 0 5.92296 9.73215 6.83378 10.7489 A0A8C0M2V3 A0A8C0M2V3_CANLF Voltage-dependent R-type calcium channel subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268] neuronal cell body [GO:0043025]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331] DEGVLTDGEKEREP;DEQEEEEAFNQKH;DFAISAKPLTRYMPQ;DHEKNKMEVKGREWKRHEFH;DPADDGQF;GGHAGKEPTIQEED;HYRRRRRGGPGP;IKSLRVLRVLRPLKTIKRLPKL;ISVLRALRLLRI;ISVLRALRLLRIF;IVHHNQPQWLTHLLYY;LPAAGALK;LRVLRVLRPLKTIKRLP;PARPLPLPLPLPLPL;RPLKTIKRLPKLKA;RVLRVLRPLKTIKRLPKL;SRRRSYHSSL;SYLRNGWNVM;TIKSLRVLRVLRPLKTIK;VENRRAFMKLRRQQQI;VISQSEPDLSCVT;VLRALRLLRIFKI;VLRPLKTIKRLPKLK;VLRVLRPLKTIKRLP;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKA;VLRVLRPLKTIKRLPKLKAVF 27 8.5 1.0022 -1.4207 0 0 13.0523 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M2X9 A0A8C0M2X9_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) AXL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] EADPFVGSPRNITGARGLTG;LGYRLAYRGQD;PGTQAEADPFVGS;QEPEEILYVNMDEGGSH;QGEPPEVTWLR;VSEPPAPA 6 8.1 1.0031 -0.88784 0 0 8.142 0 9.05672 0 12.997 0 0 9.35885 0 0 5.80369 9.99746 0 A0A8C0M2Z2 A0A8C0M2Z2_CANLF PRA1 family protein RABAC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; synaptic vesicle [GO:0008021] LLGSGSHPR;SSPGRDSSCGNKAVTVVIQ;VFVFLGLILYCVPRGE 3 19.6 0.99361 -0.16457 10.1392 0 0 0 0 0 0 0 0 0 0 0 10.6778 11.5536 10.7579 A0A8C0M2Z3 A0A8C0M2Z3_CANLF InaD-like protein PATJ Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] ACELPEREEGEGE;AIVIHEVY;ATDGRMRIGDELLE;DELLEINN;DEPFLDLGKA;EEELALWS;ETELSETIHDIN;IHEVYEEGAAARDG;IVIHEVYEEGAAARDGRLWA;PDKLQVLQ;SEEDGSLEVGIKQ;SIAGGKGS;VGTKRATDPSLKSSGMDMGP 13 6.7 0.99704 -4.0321 9.38873 10.1294 0 9.2248 7.32562 8.81259 9.98897 13.8486 10.1599 0 0 0 0 9.83804 12.1886 A0A8C0M328 A0A8C0M328_CANLF Receptor tyrosine kinase like orphan receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ARSNPLILMRLQLPKCEALPLPE;EALPLPESPD;GCWEAGEVEVPDANDP;KASASTPQRRQ;NVSNARYGGPKQKAQPFPQP;PVPAYGAYLSNFYPVQ 6 9.5 0.95612 0.049233 0 0 0 0 0 7.55474 0 0 0 0 0 0 0 0 0 A0A8C0M332 A0A8C0M332_CANLF LIM homeobox 6 LHX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" GGGGGGGG;GGRGGGGG;HYSPFSSPERAR;PDAQTLQKLADMT;PDRLWLDPWAWPSLLL 5 10.2 0.85644 0.15937 6.43508 0 0 0 0 0 0 0 0 0 9.09521 0 10.3967 0 0 A0A8C0M349 A0A8C0M349_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVETEGDLVKPGGSLRL;EVQLVETEGDLVKPGGSLRLSC 2 20.8 0.99376 -0.17449 8.78862 0 0 0 0 0 0 0 0 0 0 9.30373 8.75792 0 0 A0A8C0M364 A0A8C0M364_CANLF HGF activator HGFAC Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; zymogen activation [GO:0031638] extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ACQVSQGCPRSQDH;CRLAACESLA;LLLLLLLL;LLLLLLLLL;LLLLLLLLLV;LPGMALLLLLLLLLVPHGAQPQAG;LVLIRLKKKGDRCAIRSQFVQPIC 7 9.1 0.99443 -0.13087 0 0 11.0688 7.14751 0 0 0 0 6.49036 0 0 0 0 0 8.24432 A0A8C0M375 A0A8C0M375_CANLF RNA helicase (EC 3.6.4.13) DHX15 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DILMGVLKEVVRQR 1 1.9 0.93769 0.060924 0 5.83145 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M380 A0A8C0M380_CANLF Cilia- and flagella-associated protein 53 CFAP53 Canis lupus familiaris (Dog) (Canis familiaris) axoneme [GO:0005930]; nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DCGHCDFCCD;IKSKERDRLKVDWDQH;NEQAKLKKQ;SGYFTEMQL;VEKENFARRSSLAQEYRKQLQMQ;VGCGECAA 6 6.7 0.99899 -3.2288 0 7.03078 8.85552 0 0 6.74403 0 5.7741 7.27286 9.23314 0 0 10.0645 0 0 A0A8C0M398 A0A8C0M398_CANLF Proteasome assembly chaperone 2 Canis lupus familiaris (Dog) (Canis familiaris) LSSSHSYHRNDLQLRSTP;SAPGLGTPTAPAHA;VGQLAIDLIISTLNMR 3 9.5 0.99117 -0.14846 0 0 0 0 0 0 0 9.51225 0 0 0 0 0 0 10.0799 A0A8C0M399 A0A8C0M399_CANLF Nonsense-mediated mRNA decay factor Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleus [GO:0005634] DLYPALLGPLASLPGR;PSSLPSSPPTH;QLVHVTVINLFQ;TFPAGVSVPGTFLQ;VGENVSYKSQMRT;VHLGDIARYRN;VTDLEYALDKKVEQDLWNHA 7 8.5 0.93887 0.059745 0 0 0 0 0 0 8.94002 0 0 0 0 0 0 0 0 A0A8C0M3A2 A0A8C0M3A2_CANLF Class II aldolase/adducin N-terminal domain-containing protein ADD1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EQTFSPAK;EVQEMRNK;GGGCRGPWQRWISGQVPFQKEEEIP;PEENLDETREQ;QNLQDIKTAGPQSQVLCGVVMDRS 5 10.2 1.003 -1.0311 0 9.90173 0 0 0 0 10.9879 0 11.1632 0 0 0 0 0 0 A0A8C0M3B7 A0A8C0M3B7_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GAALAACGA;IVSWGYDCGLPKRP;PARLLVLIPL;QTCDAYYQENSNNPSQEPIIFEDM;TSDPTTWD;TSQIQSSAQ;VEVNVPLIDTQTCDAYY 7 23.9 0.99741 -3.4898 9.76127 0 0 9.84075 3.95856 0 9.23876 8.34487 0 0 0 0 0 6.4585 0 A0A8C0M3G6 A0A8C0M3G6_CANLF Complement component C9 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218] CNGDNDCGDFSDE;CNGDNDCGDFSDEDDC;CNGDNDCGDFSDEDDCE;CNGDNDCGDFSDEDDCES;CNGDNDCGDFSDEDDCESD;CNGDNDCGDFSDEDDCESDP;DCGDFSDEDDCE;DNDCGDFSDEDDC;DNDCGDFSDEDDCESDP;EDDCESDP;EVFGQFNGQKCVDPCAAGEE;NGDNDCGDFSDEDDCE;TTTFLDDIKALPSTYEKGEYF 13 11.7 0.95932 0.049108 0 0 0 0 0 0 0 0 0 0 0 0 0 7.70037 0 A0A8C0M3G7 A0A8C0M3G7_CANLF Ubiquitin-associated domain-containing protein 1 (Kip1 ubiquitination-promoting complex protein 2) UBAC1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] EINLINKRSITGRTQVGIQ;HGSLEDPKSVTHHK;MSVPQAMEWL;SLMEMGFDEK 4 12 1.0025 -1.1243 0 0 0 0 0 0 0 7.25304 0 0 0 0 9.75867 0 0 A0A8C0M3J7 A0A8C0M3J7_CANLF Nuclear transport factor 2 (NTF-2) LOC100682808 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nuclear pore [GO:0005643] HYYQLFYNDRT 1 8.7 0.9851 0.035491 0 0 0 0 0 0 0 0 0 7.1234 0 0 0 0 0 A0A8C0M3L0 A0A8C0M3L0_CANLF Ig-like domain-containing protein FCRL4 Canis lupus familiaris (Dog) (Canis familiaris) GGGAGLSS;HYVYKSSTRIIKIQELFPYPKLQVT;VTPSQPTEGSSVNL 3 8.2 1.003 -1.3292 0 0 0 5.03117 0 0 0 0 0 8.66764 0 10.4994 0 0 0 A0A8C0M3L9 A0A8C0M3L9_CANLF Complement component C9 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218] CNGDNDCGDFSDE;CNGDNDCGDFSDEDDC;CNGDNDCGDFSDEDDCE;CNGDNDCGDFSDEDDCES;CNGDNDCGDFSDEDDCESD;CNGDNDCGDFSDEDDCESDP;DCGDFSDEDDCE;DNDCGDFSDEDDC;DNDCGDFSDEDDCESDP;EDDCESDP;IEDYINEFRRMS;NGDNDCGDFSDEDDCE;TTTFLDDIKALPSTYEKGEYF 13 10.3 0.94439 0.05044 0 0 0 0 0 0 7.18309 0 0 0 0 0 0 0 0 A0A8C0M3M4 A0A8C0M3M4_CANLF Coiled-coil domain containing 125 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell motility [GO:2000145] ADGDLGYGLGRR;EALAHQRKV;SENSSKKVDDQNNPEQ;VYSSVQILNSVGCI 4 10.6 1.002 -1.3081 8.55716 0 0 8.70044 0 0 0 0 0 0 0 0 0 8.02464 0 A0A8C0M3M5 A0A8C0M3M5_CANLF EGF like domain multiple 7 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ACSTYRTIYRTAYRHSSGPASPRPR;RATRRRRPLHL 2 7.8 0.98458 0.035491 0 5.57852 0 0 0 0 0 5.24671 6.06757 0 0 0 0 0 0 A0A8C0M3N8 A0A8C0M3N8_CANLF Protein regulator of cytokinesis 1 PRC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule binding [GO:0008017] FSEVLAEESIVCLQKA;GSKAKVKKAL;YYDEDYTENLLQLH;YYDEDYTENLLQLHD 4 7.2 0.98298 -0.25182 0 0 0 0 0 0 0 0 0 0 0 9.08095 0 0 0 A0A8C0M3P7 A0A8C0M3P7_CANLF Cytochrome P450 (EC 1.14.14.1) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" DPSLLLAQATSNIICS;LLLALLLLLLLLLAL;LLLALLLLLLLLLALARP;LLLALLLLLLLLLALARPRTR;LLLLLLLL;LLLLLLLLALARPRTRGHL;LLLLLLLLL;LLLLLLLLLALARPR;MEAAGTWTLLLALLLLLLLLLALA;TLLLALLLLLLLLLALA;TLLLALLLLLLLLLALAR;TLLLALLLLLLLLLALARP;TWTLLLALLLLLLLLL;TWTLLLALLLLLLLLLALAR 14 9.5 0.99266 -0.032229 0 5.94664 0 5.53057 4.03677 4.76145 0 10.6285 0 0 5.35667 0 7.58699 8.63354 9.24793 A0A8C0M3P9 A0A8C0M3P9_CANLF PCI domain-containing protein LENG8 Canis lupus familiaris (Dog) (Canis familiaris) GAGGAGRA;HALALRAA;LPVSYLQAELAFEGEA;VLYYIFTKN;WNRMKPAPG;YLQAELAFEGEAA 6 6.4 1.0029 -1.5171 0 0 0 8.7241 0 0 0 0 0 0 0 0 0 8.1579 0 A0A8C0M3S0 A0A8C0M3S0_CANLF Harmonin-binding protein USHBP1 PDZ-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPAAELSELHLAALASLK;EERDRLRRRVRE;EFEVETERLN;REFEVETERLNSEQCIEAYELLLAL;YSELRSELSQ 5 8.3 1.0041 -1.0737 0 0 0 0 0 9.66112 11.3653 4.47197 0 8.57698 0 0 0 0 0 A0A8C0M3S5 A0A8C0M3S5_CANLF "1,5-anhydro-D-fructose reductase (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E2)" AKR1E2 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] TWEAMEDLVVMGL 1 4.3 0.9832 -0.25176 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.94089 A0A8C0M3U7 A0A8C0M3U7_CANLF Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) PIK3C3 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; endocytosis [GO:0006897]; phosphatidylinositol-mediated signaling [GO:0048015] "endosome [GO:0005768]; peroxisome [GO:0005777]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524] VSAPKAVQFI 1 1.1 0.99113 -0.27435 0 0 10.1317 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M3W5 A0A8C0M3W5_CANLF RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) CTDP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] AGESLDQSVEEEEDDEDDGDEDDHL;EDDGDEDD;EEEDDEDDGDEDDH;EQHCQQMSNKGIFHF;ESLDQSVEEEEDDEDDGDE;GARDAGKAAQRGGPSGPGGE;GVPGAHGAWPQCSRPGGPTRSFP;TAGESLDQSVEEEEDDEDDG 8 9.4 0.97762 0.046348 0 0 0 0 0 0 0 0 0 0 0 0 8.83055 0 0 A0A8C0M3Y3 A0A8C0M3Y3_CANLF BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Ubiquitin interaction motif-containing protein 1) UIMC1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; double-strand break repair [GO:0006302] BRCA1-A complex [GO:0070531] DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872] ESGKLCSAIEEKQQ;EVRIIMADKEVD;HYFWGIPFCPAGV;YCNGLIGQDTVLTRRQKEA;YTKVILCQLE 5 9.7 1.0017 -1.285 0 0 0 12.002 0 0 10.3769 0 0 0 10.8477 12.044 0 0 0 A0A8C0M3Z4 A0A8C0M3Z4_CANLF N-acetyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) N-acetyltransferase activity [GO:0008080] NEPSIRMFQK;PPLLKGLPP 2 4.5 1.0047 -0.80421 0 0 0 0 0 0 0 0 0 0 8.00489 0 0 0 0 A0A8C0M3Z5 A0A8C0M3Z5_CANLF hydroxymethylbilane synthase (EC 2.5.1.61) (Hydroxymethylbilane synthase) Canis lupus familiaris (Dog) (Canis familiaris) porphyrin-containing compound biosynthetic process [GO:0006779] hydroxymethylbilane synthase activity [GO:0004418] LDELQEFSSSWLRL 1 4.7 0.93797 0.075091 0 0 0 0 0 0 10.3268 0 0 0 0 0 0 0 0 A0A8C0M3Z6 A0A8C0M3Z6_CANLF Phosphatidylinositol 4-kinase type 2 (EC 2.7.1.67) PI4K2B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524] AEAAGEEGAASPAAAGD;ESPEPGRPASAGGGGSLPEE;LVSETFNYS;PASAGGGG 4 9.6 0.99101 -0.22078 0 0 0 0 8.64288 0 0 0 8.70822 0 8.71239 8.28179 0 0 0 A0A8C0M409 A0A8C0M409_CANLF DAB2 interacting protein DAB2IP Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] ESLLSPSSAVE;PGCSDRGAAPAAGPGPPGSH;QSTGKVKDFLT;TPGRDLPASSLG;TTTGCCGGP 5 4.8 1.0037 -0.82431 0 0 6.68201 0 0 0 8.6901 0 5.60579 0 7.50223 0 0 0 10.545 A0A8C0M445 A0A8C0M445_CANLF F-box protein 46 FBXO46 Canis lupus familiaris (Dog) (Canis familiaris) EEPPPPGQLFFLQSRGPDGPPEPP;SSGGGGGS 2 5.2 0.99426 -0.28568 0 0 0 0 0 0 0 0 0 0 10.575 0 0 0 0 A0A8C0M462 A0A8C0M462_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST1 Canis lupus familiaris (Dog) (Canis familiaris) glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] Golgi apparatus [GO:0005794] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] GIRLLLILR;HVQKRKPYPSIE;SLYHVHLQNWLRFFP 3 11.8 1.0033 -1.328 0 0 8.71973 0 0 0 0 0 0 0 0 0 4.46826 0 0 A0A8C0M468 A0A8C0M468_CANLF Ral transcription factor IIA subunit 1 GTF2A1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytosol [GO:0005829]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550] protein heterodimerization activity [GO:0046982]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; TBP-class protein binding [GO:0017025] DEDEEEDYDDE;EDEEEDYDDEEEED;EDYDDEEEE;FHSEEQQLLLQVQQQHQPQQQQ;GDTSSEEDEDEEEDYD;SEEDEDEEEDYD;TSSEEDEDEEEDYDDEEE 7 11.7 1.0026 -1.1833 6.92778 0 0 4.59962 0 4.06083 5.25826 0 0 0 0 0 0 0 0 A0A8C0M476 A0A8C0M476_CANLF DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) POLG Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial DNA replication [GO:0006264] gamma DNA polymerase complex [GO:0005760]; mitochondrial nucleoid [GO:0042645] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GVACPYRAIES;NWVVQSSAVDYLHLM;PKMEDGTLQAGPGGASGP;TITRRAVEPTWLT;VIAGPAAP;WDGFPLHYSERHGWGY;WEMKKSLMDLANDACQL 7 8.4 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 6.421 0 0 0 A0A8C0M4A1 A0A8C0M4A1_CANLF FAD-binding PCMH-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) steroid metabolic process [GO:0008202] cytoplasm [GO:0005737]; membrane [GO:0016020] delta24(24-1) sterol reductase activity [GO:0000246]; FAD binding [GO:0071949] PSKLNSIGNYYKP;VEGLLYSL 2 4.5 1.0025 -1.3574 0 0 9.94862 0 0 0 0 0 0 0 6.34318 0 0 0 0 A0A8C0M4B0 A0A8C0M4B0_CANLF Alpha-mannosidase (EC 3.2.1.-) Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GPSGSVSGSERATWFRTPHLLWPW;VRDRTPAHSGGTGRSRD;VYTTVVEQLMLQKQRRFI 3 5.8 0.97387 0.041303 0 0 0 0 0 0 0 0 5.91516 0 0 0 0 0 0 A0A8C0M4D4 A0A8C0M4D4_CANLF Family with sequence similarity 53 member A Canis lupus familiaris (Dog) (Canis familiaris) AACPRTSQRRGCAAC;PSSASGGCMDSCEGSSGLPRR 2 10 0.95124 0.053901 0 0 0 0 0 0 0 0 8.82197 0 0 0 0 0 0 A0A8C0M4E4 A0A8C0M4E4_CANLF FLYWCH-type zinc finger 1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] MRSHCHLPDL;QVEEQVGAVQPTLQAPE;TLNLSRTRPRKRPKVLPAQPPAL 3 7 1.0014 -0.69775 8.15775 0 9.70231 0 0 0 0 0 0 0 0 9.83378 0 0 0 A0A8C0M4E9 A0A8C0M4E9_CANLF Nucleolar protein 16 NOP16 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] nucleolus [GO:0005730] RKRLNRNARRKAAPRIEC 1 12 0.99074 -0.2747 0 0 0 0 0 0 0 0 7.88655 0 0 0 0 0 0 A0A8C0M4F2 A0A8C0M4F2_CANLF FAT atypical cadherin 2 FAT2 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] ASVLVEIF;DQPRKGHQLF;DVDELQNLK;EGASCNCPHPYMGDRCE;ELTIKASD;EVLVEDINDNPPTFSQLVYT;FHQLTPEELVSDHWR;FQLNYSTSVQENSPIGSK;GATIWPPTYSR;IILTDENDNP;IVEEEPLMLFTT;KSLDFETSPKF;LASLQPAEATAGVDVL;LEDLMPPRPPSPREHLLA;LVLLRLQVVP;LVSATSSSEVTYE;QELDCETHQ;SLERELDFER;TSILTVTA;TSPGHFIL;YEGSDMVESDYGSCEEVMF 21 6 0.99663 -4.7668 8.12366 10.8103 0 9.20819 7.27118 7.70757 0 11.3467 12.9796 0 6.07429 9.55132 10.9798 12.7979 10.4255 A0A8C0M4F3 A0A8C0M4F3_CANLF HSac2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDGDIQGVWLLTEREGFGIRIQW;GAGGGGGG;GGGGGRPG 3 16.4 0.99312 -0.28156 0 0 0 0 0 0 0 12.9352 0 0 0 0 0 0 0 A0A8C0M4G3 A0A8C0M4G3_CANLF Thyroid hormone receptor interactor 11 Canis lupus familiaris (Dog) (Canis familiaris) EEKRACQLEDETNA;MTYMDVIRDYRG;QDHLLGKP;QLQQKQVEIALLREKQQV;YHQTIKELSSTQN 5 3.4 0.99215 -0.038422 0 0 0 0 8.43975 0 8.58605 0 0 9.4089 0 0 8.65112 0 0 A0A8C0M4G5 A0A8C0M4G5_CANLF Uncharacterized protein LOC611406 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] ELFDGQQL;MHEDSTLRIYFQRISLYLQDKNHSP;PCVNYTND 3 21.9 0.97536 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 7.84423 0 A0A8C0M4H7 A0A8C0M4H7_CANLF Small nuclear RNA activating complex polypeptide 4 SNAPC4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DLAGSKGP;GGSGNSED;GVGHWAKI;LDLDLLSQESE;LTQLGQFRWLEYLHQ;LVQEMRVGSH;VGPPANEETREKA;VGSHIPYRRIVYYMEG 8 5.9 0.99769 -3.3742 0 0 7.20232 6.92647 0 5.81934 11.1562 0 10.98 0 0 0 0 0 10.4775 A0A8C0M4L1 A0A8C0M4L1_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK7 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; rhodopsin kinase activity [GO:0050254] FYDKFLQWKVFEMQ;TFLQDQPFQDFLASPFYDKFLQW;TGAVPIAWQEE 3 7.2 0.99453 -0.12398 0 0 0 0 9.79585 0 0 0 5.89108 0 0 0 0 0 9.26655 A0A8C0M4M0 A0A8C0M4M0_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (NADH-ubiquinone oxidoreductase 19 kDa subunit) LHX6 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial intermembrane space [GO:0005758]; respirasome [GO:0070469] AVGLPQSQRVPPHYGNRE;EPPGTAHAPRLAVG;SSVLKAAAHHYGVQCDKPNKEFML;VGLPQSQRVPPHYGNRE 4 22 0.83807 0.19694 0 0 0 0 0 0 0 7.33842 0 0 10.5154 9.1955 0 10.1406 0 A0A8C0M4M5 A0A8C0M4M5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] LLTGMDPQP;PRESEEEEAEAGAA 2 4 1.0047 -1.0507 0 0 0 0 0 8.21611 10.3705 0 0 0 0 8.48961 9.21851 0 0 A0A8C0M4N3 A0A8C0M4N3_CANLF CARD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] EDNTPKVT;EVQLFQRVLNLKPS;QPHPFQPKPTQT;SAVFFFTDYLGEKEWDL;SEIIERERKRLLEILQK;VEEEDYNDSEHSVYDGEE 6 8 1.003 -0.85212 5.53987 0 0 0 0 0 6.5151 0 0 0 0 9.75894 0 9.02023 8.99732 A0A8C0M4S1 A0A8C0M4S1_CANLF Condensin-2 complex subunit D3 NCAPD3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] "condensed chromosome, centromeric region [GO:0000779]; condensin complex [GO:0000796]; nucleus [GO:0005634]" EEHGPAESIWSFF;EIEEQEDEESICF;IECIFHFNNYE;LASAVMQEAQKRLISQ;LEEDDMAL;QMLNVILMLGAGEGV;RKRGKPPRKEDIEVDEIEE;SLFFRFVSTLIDSH;TNLLQEEFVKWKGSLFFRFVSTL;VLAWALLTLLSTENQELS;VLSTCVQSLSDIVLKQSGP;VMFDKCIQ 12 11.2 1.0031 -2.284 0 0 0 10.6235 0 10.9338 0 11.9274 3.64039 0 11.5418 9.84364 10.24 0 0 A0A8C0M4T1 A0A8C0M4T1_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] RETYGHLGALGDPAKMPPPPPSLQ 1 27.3 0.93879 0.06311 0 0 0 0 9.92238 0 0 0 0 0 0 0 0 0 0 A0A8C0M4U7 A0A8C0M4U7_CANLF WASP like actin nucleation promoting factor WASL Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779] AIHSSDEDEDEDDEE;DEDDEEDFEDDD;EDEDDEEDFEDDDEWE;EDEDEDDEEDFED;HSSDEDEDEDDEED;HSSDEDEDEDDEEDFEDDDE;IHSSDEDEDEDDEEDFEDDDEWE;KKKGKAKKKRLTK;SKAIHSSDEDEDEDDEEDFEDDDEW 9 7.7 0.94018 0.070099 7.12422 6.52102 0 4.62188 0 6.49745 0 4.32826 0 0 0 6.66306 0 5.90128 4.47366 A0A8C0M4U9 A0A8C0M4U9_CANLF Endosome-associated-trafficking regulator 1 Canis lupus familiaris (Dog) (Canis familiaris) AGDLLDEDEDEDEDDGWNGAYLPST;ASLTVVKQ;DEDEDEDEDDGWNG;EDEDEDDGWNGAYLPS;LDEDEDEDEDDG;VGDTDFGYGKGKCTKQGPPGA 6 12.4 1.0027 -0.84133 8.41232 0 0 0 0 0 9.25132 7.49057 8.09566 0 0 0 0 5.48394 0 A0A8C0M4V7 A0A8C0M4V7_CANLF "ATP synthase subunit f, mitochondrial (ATP synthase membrane subunit f)" Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial proton-transporting ATP synthase complex [GO:0005753]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" VLVAYVLFNYCHSYKEL 1 17.7 0.99129 -0.22174 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2586 0 A0A8C0M4Y1 A0A8C0M4Y1_CANLF C2 domain-containing protein CC2D2A Canis lupus familiaris (Dog) (Canis familiaris) DFRVHFGQIFNLQIFNWPE;KPLNPPQEL;LETEFGTEPGEKVQRT;LVREKFDSQEDEKLLQ;RFRLLCLRSQEVPEFR;SGIHTRIERHWL 6 5.9 1.0016 -1.4138 0 0 0 7.61456 0 9.39238 0 0 6.52608 0 0 3.48078 9.34933 0 11.3925 A0A8C0M4Y7 A0A8C0M4Y7_CANLF Leptin receptor gene-related protein (Endospanin-1) (OB-R gene-related protein) LEPROT Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400] endosome [GO:0005768]; Golgi membrane [GO:0000139] HETLIWGIGYLTCGIETLE;SPIPHFIAKRATYDSD 2 28.7 0.93411 0.099095 0 0 0 0 0 5.44722 0 0 0 0 0 0 8.38504 0 0 A0A8C0M4Z5 A0A8C0M4Z5_CANLF Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] EEHKIFLLKVLLPLHKVKSLS;HNRNVITEPIY;IIESEGTSPVL;KIFLLKVLLPLH;PLKEEHKIFLLKVLLPLHKVK;VLFDFVSDPLSDLKWK 6 11.4 0.99278 -0.051918 0 0 0 0 5.54649 7.66014 0 12.5849 7.16832 0 0 0 0 0 0 A0A8C0M4Z7 A0A8C0M4Z7_CANLF Protein ABHD13 (Alpha/beta hydrolase domain-containing protein 13) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyl-(protein) hydrolase activity [GO:0008474] GEASEEGLYLDSEAVLDY;VELLILSLSFS 2 7.8 0.98509 -0.24134 0 0 0 0 8.84307 0 0 0 0 0 0 0 0 10.6511 0 A0A8C0M527 A0A8C0M527_CANLF Semaphorin 4D SEMA4D Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] EVQLEKFH;LEPDSCRSTWWPQNFFVRPQRSAPL;TVEQSHTKWVRYNGA 3 5.7 0.99115 -0.29648 8.90147 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M532 A0A8C0M532_CANLF T-complex 11 like 2 Canis lupus familiaris (Dog) (Canis familiaris) ASLSDYEC;LITNNMVGALTEGLPEL;LPSPQKCMPPM;QELTEKLNQLKIIACLSL;VIQQELEELGSQFA 5 13 0.98887 -0.19799 0 11.4105 8.94661 7.66647 8.09724 7.99095 9.00677 0 8.78293 0 9.96372 0 0 10.1886 8.54836 A0A8C0M533 A0A8C0M533_CANLF Nonsense-mediated mRNA decay factor Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleus [GO:0005634] DLYPALLGPLASLPGR;FRSGAAVNAAEAEAAAG;PSSLPSSPPTH;QLVHVTVINLFQ;TFPAGVSVPGTFLQ;VHLGDIARYRN;VTDLEYALDKKVEQDLWNHA 7 8.8 0.99048 -0.21304 5.22338 9.57491 0 0 8.72288 0 0 0 6.44351 9.64057 0 9.51233 0 0 0 A0A8C0M540 A0A8C0M540_CANLF Armadillo repeat containing 5 Canis lupus familiaris (Dog) (Canis familiaris) NLAMEPESCGDIHSAGAV;VIPALPPPMPLDL;VQAESPFGVGALTHL 3 4.9 1.0028 -0.77881 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1417 0 A0A8C0M557 A0A8C0M557_CANLF BRMS1 like transcriptional repressor BRMS1L Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826] EDEDTESSSVSEDGDSSEMDD;EDGDSSEMDDEDCERRRME 2 10 0.93295 0.096576 0 0 0 0 0 7.86102 0 0 6.96636 0 0 0 0 0 0 A0A8C0M576 A0A8C0M576_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) INSRR Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] AQGLEAGEESTPVALK;EDGELEAEMEPGCC;GVVSQGQPTL;TMPHREADGIPGKV;YKESPFQNATEHTGP 5 5.3 1.0013 -0.70239 9.09162 0 0 0 6.5196 0 0 8.40135 0 0 8.89069 0 0 0 0 A0A8C0M580 A0A8C0M580_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] TYNKWWCQGAEWKSCH;VIQGSPALMAVSDAVSGPMR;WNNADTYWCGIERSGTDLG 3 30.1 0.85714 0.16005 0 0 0 0 0 0 9.87868 3.976 0 9.46919 0 4.01917 0 9.67631 4.361 A0A8C0M593 A0A8C0M593_CANLF MAM domain-containing protein MAMDC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAGGGGGG;AAGGWEDASVGRLQWR;EAAGATLRSPV;GGGGGGGG;GGGGGGPG;GQRSPPAC;LVDLDGPGQQGAGVDDVTLKD;LVSVAEPSSPAVLS;VLFETGVLGPG 9 8.4 0.98378 -0.24311 5.97916 6.39587 8.77919 0 0 0 0 0 0 0 0 7.56255 8.1876 0 11.4553 A0A8C0M594 A0A8C0M594_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AALQRIDRALR;DLAAQRPPRPS;SPSSSTSTGLAPQPA;VLPPGGGA 4 6.5 0.95169 0.053901 0 0 0 0 0 0 7.23831 0 0 0 0 0 0 0 0 A0A8C0M5C2 A0A8C0M5C2_CANLF Nedd4 family interacting protein 1 NDFIP1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion transport [GO:0030001]; positive regulation of protein ubiquitination [GO:0031398]; ubiquitin-dependent protein catabolic process [GO:0006511]; vacuolar transport [GO:0007034] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] WW domain binding [GO:0050699] ACGSRYQQL;LSLIKWILIVRFS;QYWLWWVFLVL 3 12.5 0.9848 -0.25483 0 6.9493 0 0 0 0 0 0 0 0 0 9.21898 0 0 9.85304 A0A8C0M5C3 A0A8C0M5C3_CANLF Family with sequence similarity 187 member B FAM187B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGPVLKGLKLTLLVGIVLGLLGL;AGPVLKGLKLTLLVGIVLGLLGLL;KGLKLTLLVGIVLGLLGL;KGLKLTLLVGIVLGLLGLLL;PSQTGFYHCQDENSIQ;PVLKGLKLTLLVGIVLGLLGLLL;RQQGAREASKGKAGP;VLKGLKLTLLVGIVLGLLGLLL;VLKGLKLTLLVGIVLGLLGLLLK 9 14.8 0.9888 -0.26149 0 0 0 0 9.23127 0 0 0 0 0 0 0 0 0 0 A0A8C0M5F0 A0A8C0M5F0_CANLF DnaJ heat shock protein family (Hsp40) member C6 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583] clathrin-coated vesicle [GO:0030136] GAAAGPAQAGQSGVEDMFH;GGGAAAGP;GPAQAGQSGVEDMF;IPPDNPRHFGQ;LEGKQKAADFEDLLSGQ;LVNPESEQ;SPSHRRYLGYM;VHASSTPAVNIQ 8 8.7 1.0034 -1.5749 0 0 10.3668 0 0 7.83605 0 0 0 0 0 0 0 11.3197 10.4538 A0A8C0M5F2 A0A8C0M5F2_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] ERNQEIPHKGAFC 1 4.8 0.98923 -0.26137 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.8848 A0A8C0M5I0 A0A8C0M5I0_CANLF Platelet endothelial aggregation receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CPPDTYGVGCSARCSCDNAIAC;CPPGWTGHLCLEGCS;DCDHSDGCDP;EGCASRCDCDHSDGCDPVHGHCQC;FSSKEELGASVASL;HPQHGSCSCPP;KSGACLCPSGLQPPH 7 10.1 0.95193 0.053901 0 0 0 0 0 0 0 0 0 0 0 9.31111 0 0 0 A0A8C0M5J2 A0A8C0M5J2_CANLF CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) PGS1 Canis lupus familiaris (Dog) (Canis familiaris) cardiolipin biosynthetic process [GO:0032049] mitochondrion [GO:0005739] ATP binding [GO:0005524]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] IDEIVTET;PRSWGACPTAWAGTGTAGAGGPDQ 2 5.3 0.99415 -0.28539 0 0 0 0 0 8.68682 0 0 0 0 0 0 0 0 0 A0A8C0M5J7 A0A8C0M5J7_CANLF TBC1 domain family member 2 Canis lupus familiaris (Dog) (Canis familiaris) AEPAGGAEVLPP;EEAEPDDF;EQEEAEPDDFLGPV;LLMDKNQAKQQVICKLSE;PSDPSTPGKDPADSPKP 5 6.6 0.9871 -0.38113 20.2226 7.10087 20.1338 12.6732 18.8423 10.4199 4.79228 11.6877 0 0 9.56866 19.9069 20.1589 10.3856 11.1941 A0A8C0M5K2 A0A8C0M5K2_CANLF Transmembrane protein 231 Canis lupus familiaris (Dog) (Canis familiaris) ciliary membrane [GO:0060170] GVSPIVLRCARVPVICEW;VLSWSPLLLSSQTGPFAVA 2 16.7 0.99159 -0.036772 0 0 0 0 14.4075 0 0 0 0 8.82305 0 0 0 0 0 A0A8C0M5K8 A0A8C0M5K8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVGFGMLKAKVAGGSP 1 19 0.95936 0.049233 0 0 8.18527 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M5L5 A0A8C0M5L5_CANLF Purine rich element binding protein A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AAGGGGGG;EQLHQQQQQ;GGGGGGGG;GGGGGGSG;SGGGGGGA 5 7.9 0.98901 -0.21835 0 0 0 0 0 0 10.8502 0 0 0 0 0 0 0 0 A0A8C0M5L9 A0A8C0M5L9_CANLF TOPBP1 interacting checkpoint and replication regulator TICRR Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; response to ionizing radiation [GO:0010212] nucleus [GO:0005634] GKRQRDTSNLESSSLQ;KAVSVPKTLE;KDWPRRKRAV;LEEILGLKTALIRHKS;PFFDVMDI;RMVCLTEDSAYLAKFL;TTPDTIKDWPRR;VFPTTAEESPFSRA 9 6.1 0.99951 -2.9134 0 5.7555 0 0 9.46887 0 0 8.48168 0 0 0 0 10.3138 0 0 A0A8C0M5N3 A0A8C0M5N3_CANLF Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) CDK20 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EIKALQEIEDNQ;GVPFCPAQTGEIVAL;IVALKKVALRRL;LQPGMDCGVPFCP 4 9.3 0.99639 -0.57685 0 0 0 0 0 0 0 0 0 0 0 0 11.0516 0 0 A0A8C0M5N4 A0A8C0M5N4_CANLF STAS domain-containing protein SLC26A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271] LQDIPRQFF;LVSFYTFHE;LVSSYPVTGSF;PAGVQRRLPILAWLPD;SRALEASPPRCAVLECTHVC;TAEGLPPVR 6 12.2 1.0036 -2.389 0 0 0 0 10.0588 0 10.3817 0 0 0 0 6.06686 0 0 0 A0A8C0M5P4 A0A8C0M5P4_CANLF Metastasis associated 1 MTA1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to ionizing radiation [GO:0010212] NuRD complex [GO:0016581] histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] AECTARLPEASQSP;GCLCLRSLIQARASLWHPRCHTW;GVVNGAGA;KQIDQFLVVARSVGT;RGEEGAAVFAE;SETKRAAR;TKLTRIARRLCREILRPW 7 13.1 1.0028 -1.7438 0 6.54671 0 0 0 0 7.71218 0 10.5808 7.74403 0 8.99969 9.81495 0 0 A0A8C0M5Q5 A0A8C0M5Q5_CANLF PKD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEPGAPGL;DENQVFVAVQEWYQMD;FEEEHHVLYLD;GDGDGDGD;LEVVPVVG;LFLSMDEGATFQKQ;LLLLLLLL;RPLLLLLLLLAACG;VGVGDGDGDGDGDGDGD;VLQDSKVVRVL;VSHSQGVQSVIQ 11 9.4 1.002 -1.2343 0 0 0 0 5.67305 0 13.4415 11.7503 0 0 0 0 7.87535 10.6284 10.9913 A0A8C0M5R3 A0A8C0M5R3_CANLF Eukaryotic translation initiation factor 4 gamma 2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] AEDAPNFDGPAAEG;GVREMRAPKHFLP;KELPARIRF;LDHCPKLE;LGGLADMFGQMPGS;LILKGVILLIVD;PAKTSKKPPPSKEELL;PARSTRRDDNS;QQSKVNMQKMLPEIDQNKDRM;QVPKLQPQITMIPPSA;VGVESKLILKGVILLIV 11 16.1 1.002 -1.4621 10.246 10.8709 0 3.17916 8.79805 8.73064 0 0 0 0 12.8757 0 0 0 13.3548 A0A8C0M5R6 A0A8C0M5R6_CANLF Protein cornichon homolog 4 (Cornichon family AMPA receptor auxiliary protein 4) CNIH4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane [GO:0016020] CCR5 chemokine receptor binding [GO:0031730] KLGFHLLCFFM 1 7.9 0.98978 -0.26577 0 0 0 0 0 0 0 0 0 0 0 0 12.359 0 0 A0A8C0M5T2 A0A8C0M5T2_CANLF Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3 gamma) (eIF3 p40 subunit) EIF3H EIF3S3 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732] cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] metallopeptidase activity [GO:0008237]; translation initiation factor activity [GO:0003743] EVPIVIKNSHLINVLMWEL;KQQQQKHQYQQRRQQENMQRQSR;MRNTSKQQQQKHQYQQRRQQEN;TGPAGKGK 4 16.6 1.0019 -1.2504 5.87046 11.0262 0 0 0 0 0 0 9.43563 0 0 0 0 11.3371 14.5494 A0A8C0M5T5 A0A8C0M5T5_CANLF Methylosome subunit pICln Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTLYIAES;MFTVMCECQAWHPDPEDEDSDDYDG;VMCECQAWHPDPEDEDSDDYDGEEY 3 16.1 0.98 0.035538 0 0 0 0 0 0 7.01491 0 0 0 0 0 0 0 0 A0A8C0M5V1 A0A8C0M5V1_CANLF Enoyl reductase (ER) domain-containing protein LOC610994 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] IVLETGADVSTVKEGDRVIG;VGFAGGTI;VSAMGLYWSRYKEQ 3 11.7 0.9937 -0.14928 0 0 0 0 0 0 0 0 8.98325 0 0 8.32504 0 8.80835 0 A0A8C0M5X6 A0A8C0M5X6_CANLF "CTR9 homolog, Paf1/RNA polymerase II complex component" CTR9 Canis lupus familiaris (Dog) (Canis familiaris) "blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; inner cell mass cell differentiation [GO:0001826]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]; trophectodermal cell differentiation [GO:0001829]" Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791] SH2 domain binding [GO:0042169] FVLPFFGLGQ;GKLQECKQTL;KDEKSNLKEVLNAVKELELAHRY;KKKRRRPPKGE;LSRAYTIDP;SLIGNLHLAKQ;SVQSGRSRS 7 7.1 1.0021 -1.2775 0 0 0 0 0 5.34721 8.7708 10.813 10.7756 8.37617 0 0 14.0333 10.5499 9.39635 A0A8C0M5Y5 A0A8C0M5Y5_CANLF Metalloproteinase inhibitor 2 (Tissue inhibitor of metalloproteinases 2) Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191] AGPGARRPRRPRRRRPRRPRRRRRP;DIYGNPIKRIQYEIKQIKMFKGP;GGGGGGGG;GPGARRPRRPRRRRPRRPRRRRRPR;REVEGKGEGEGGRGK 5 14.5 0.85451 0.17125 0 6.69153 0 0 3.51879 0 0 0 0 0 4.73731 0 8.57686 0 0 A0A8C0M5Z2 A0A8C0M5Z2_CANLF Aminotransferase class V domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) L-serine biosynthetic process [GO:0006564] O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648] LDRWGPFIYVM 1 6 0.98219 -0.25051 0 0 9.66519 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M604 A0A8C0M604_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221] plasma membrane [GO:0005886] inhibitory MHC class I receptor activity [GO:0032396] EAAGLDGWQRSHEN;EPSLSAQPGSLIHSGDNL;GVNMSLSCSSRY;SAPSAPLDIL;VTSDHQGTYRCYSSHN 5 12.5 0.98636 -0.41392 0 9.60413 0 0 0 0 0 0 10.4845 0 0 0 0 8.76623 9.60101 A0A8C0M630 A0A8C0M630_CANLF CCD97-like C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EEEACLEEEEEEDDSDEEDQ;EEEEEEDDSDEEDQSS;QEEEEACLEEEEEED;SDLLLQSYQERE 4 10.5 0.8149 0.20178 8.47184 8.29398 3.97682 0 0 0 0 0 0 0 0 0 0 0 7.78234 A0A8C0M631 A0A8C0M631_CANLF Progestin and adipoQ receptor family member 4 PAQR4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023] PMTMPWGQLGQDG 1 4.8 0.99226 -0.16547 0 0 0 0 0 0 0 11.6045 0 0 0 0 0 0 0 A0A8C0M640 A0A8C0M640_CANLF G-protein coupled receptors family 3 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] G protein-coupled receptor activity [GO:0004930] CPWDAPTPDSSAKAE;DEESLQNQQNAHTSRM;DPPLLDSLLRRKL;EAEEAPTSEKAKICPWEVN;EDEESLQNQQN;EVTPARAELCPWEV;ILKLYRVLQLFLSRSA;LLRRKLAKKASRESRESRESGE;TAEVCPWDAEDTVP;VGCRAAEV 10 5.8 1.0026 -1.4843 9.27254 8.21062 12.8104 3.55533 9.27998 0 0 12.3181 10.1454 7.77854 10.7006 13.7708 0 8.79636 6.9751 A0A8C0M644 A0A8C0M644_CANLF Multiple EGF like domains 8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] ALGDLVLYNFSAN;CLARHPRTLQ;CPPEDECANGHHDCNETQNCHD;GGQDGGGH;GGVALGRLLALTLPPDPCRL;INQREVFWAGNC;LFAAYLARYPHGG;LLFFRQDQAHIDL;SFHAAAYVSS;VGGGTCRP;VSGGRTQHDLFSSGLFRF;YCGGGGGA;YHLDYCSMYTDHSVCSRD 13 6.4 1.0029 -2.491 0 0 0 0 5.67536 9.43892 0 9.72223 0 10.9207 8.8751 10.2119 6.07731 3.43176 10.9356 A0A8C0M648 A0A8C0M648_CANLF CUGBP Elav-like family member 4 (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GLAQGQSNPPQSRAELGI;LTYCERESALKAQSALH 2 7.2 0.98665 -0.2599 0 0 0 0 0 0 0 0 10.165 0 0 0 0 0 0 A0A8C0M658 A0A8C0M658_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RPLTQQDAA;YKRGRASHSRR 2 8.9 0.9886 -0.26422 0 0 0 0 0 0 0 0 0 0 0 0 13.1746 0 0 A0A8C0M673 A0A8C0M673_CANLF Cilia- and flagella-associated protein 263 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cilium [GO:0005929] LKGYRKAWNKMKTTNEQLQALCPPR 1 7.7 0.97885 0.035538 0 0 0 0 0 0 5.71191 0 0 0 0 0 0 0 0 A0A8C0M675 A0A8C0M675_CANLF CID domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124]; termination of RNA polymerase II transcription [GO:0006369] cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849] mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993] DEQVSAKGVREEQRSPFND;EKITKKELDQ;EQFEQYWDEEEEEW;GAVESCEICQEQFEQYWDE;GDEHSKSPHLRHRESW;LAVSLSVQQETSN;SGAQFDRK;SVTRDGPTKMIF;TAKAPSSEKLPVMY;TKRWKSGWEENKSLQ;YAENLSPHEGRRRHDEQV 11 8.7 1.0029 -1.5884 10.6701 0 0 0 0 0 10.366 0 13.7936 0 12.3065 0 10.8805 0 9.95334 A0A8C0M679 A0A8C0M679_CANLF Kallikrein-related peptidase 2 KLK2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CRGANPTAPAAAEWVPG;VRKSFIHPLYKTKVPRAVIR 2 11.3 0.95107 0.057856 0 0 0 0 0 7.86425 0 0 0 0 0 4.46002 0 0 8.31279 A0A8C0M685 A0A8C0M685_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASTSEVPAFEFTAE;EQTFKKMENYLR;GQTGANGG;TSEEENESDSSSCRT 4 6.9 0.98642 -0.39388 0 0 9.24994 0 0 0 11.0408 8.62395 0 0 0 0 10.5317 0 4.27284 A0A8C0M686 A0A8C0M686_CANLF Reticulon RTN2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018] PPPSEVLTPQ;SLRVYRKVL 2 4.3 1.0019 -1.4157 0 8.18854 0 0 8.02558 0 0 0 0 0 0 0 0 0 7.82579 A0A8C0M689 A0A8C0M689_CANLF Transforming growth factor beta TGFB1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781]; regulation of cell population proliferation [GO:0042127]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160] GLRLLPLLLPLLRLL;GLRLLPLLLPLLRLLVL;GVVRQWLSH;LYQKYSNDSW;MATPLERAQHLHSSR;PPSGLRLLPLLLPLLRLLVLTPGRP;PSGLRLLPLLLPLLRLL;PSGLRLLPLLLPLLRLLVLT;QGEVPPGPLPEAVLALYNST;STRDRVAGESAEP;YEKVKKSPHSIYMLF 11 27.9 1.0039 -0.81438 0 6.70957 10.7814 0 11.1629 8.90159 11.9605 4.89317 0 7.96636 8.35165 0 0 6.63848 0 A0A8C0M6A4 A0A8C0M6A4_CANLF Tubulin tyrosine ligase like 11 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] GCGRSSGNPADELRPPRPVT;LRLMDPLKNKREKHFPDIY;PFGRRLPCDIYW;SLNIHSGN 4 8.1 0.99119 -0.2693 0 0 0 8.61445 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6C6 A0A8C0M6C6_CANLF Mirror-image polydactyly 1 MIPOL1 Canis lupus familiaris (Dog) (Canis familiaris) FVTPVTFTSLGIME 1 3.5 0.98406 -0.24712 0 0 0 0 0 0 0 0 0 0 0 0 10.9385 0 0 A0A8C0M6C8 A0A8C0M6C8_CANLF Protein transport protein sec16 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; protein transport [GO:0015031] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] AEGGWPATEQDQ;EGAAGGSANPEPASE;EQEELRSFPGPLGK;GALSMFFQGGETENE;GVSAPQAR;HYGSRFRDPRTC;KKTTKLVLIGS;LQNQPVLIAQPDQSYNLAQP;NPLTQGNSPESHL;VGLAGGGGPNLEAPDSAPH;YWYDAAEYDPYRKESY 11 6.8 0.95281 0.05044 0 0 7.90629 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6D3 A0A8C0M6D3_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VGEGGAGEPPPG 1 2.7 0.95267 0.05044 0 0 0 0 0 0 0 0 9.64938 0 0 0 0 0 0 A0A8C0M6D6 A0A8C0M6D6_CANLF Barttin CLCNK type accessory subunit beta Canis lupus familiaris (Dog) (Canis familiaris) chloride transport [GO:0006821] membrane [GO:0016020] FHDFALIDCSHTRR;PVQLSAAVPEDKGGGREGFRHRS 2 12.2 0.99038 -0.26677 0 0 9.41889 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6H5 A0A8C0M6H5_CANLF Transcription factor TFIIIB component B'' Myb domain-containing protein BDP1 Canis lupus familiaris (Dog) (Canis familiaris) EEREIHLEE;EIDLKETEERNLSLMEKES;ENVPEMVDATEEREIHLEETE;EQEKKTEKSL;GKKTVLSQDKTDAE;GLEETRSEISI;GTPTMPEIQQENV;ILLQPRDS;ISSEVSARKDCIDSKE;PENILLQPRDSDTHLQ;PSPKPAES;QIVEGQQES;SLTSGDDCQ;STEAAITLL;TLVEIPTNAVEDFNDTTAQLMP;VPIGLRSPEPVS 16 7.4 1.0028 -2.5637 8.95905 10.9939 7.66569 0 9.92926 5.29473 0 0 10.093 10.2968 0 11.9025 8.11103 0 11.4273 A0A8C0M6H6 A0A8C0M6H6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IWHPFLIKTLQSV;MDAFLESHKL;MNEKGEITTNT 4 5.4 0.93813 0.059565 0 0 3.71962 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6I3 A0A8C0M6I3_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) complement activation [GO:0006956] extracellular region [GO:0005576]; membrane attack complex [GO:0005579] LVAVASSCRFLQ 1 6.1 0.95455 0.05044 0 0 0 0 0 7.56887 0 0 0 0 0 0 0 0 0 A0A8C0M6I7 A0A8C0M6I7_CANLF CIDE-N domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic DNA fragmentation [GO:0006309] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA endonuclease activity [GO:0004520] DNSELVLLTSG 1 3.3 0.97946 0.035491 6.58658 0 9.24643 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6K7 A0A8C0M6K7_CANLF Homologous recombination factor with OB-fold HROB Canis lupus familiaris (Dog) (Canis familiaris) recombinational repair [GO:0000725] DFGRGPWLAMKSALGLDE;VLRKAALKQLPRNK 2 4.9 0.92183 0.10908 0 0 0 0 0 0 0 0 0 0 0 0 8.79438 4.48755 0 A0A8C0M6L2 A0A8C0M6L2_CANLF FGGY carbohydrate kinase domain containing FGGY Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" VVTKNLRETCWDK 1 2.8 0.98907 -0.26055 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.6418 A0A8C0M6L3 A0A8C0M6L3_CANLF Membrane frizzled-related protein MFRP Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ADGSDETNCSAKFLGSAE;CLFDRLEISPEPEG;LASLLLLLLGLLVAIILG;LLLASLLLLLLGLLVAIILGQ 4 11.4 0.98494 -0.25773 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0779 0 A0A8C0M6L7 A0A8C0M6L7_CANLF HMG box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AKGGTTSD;FCKPPPLASEFPSHSL;GSDGDVRIWEDLDDD;IIRCYNDEQDNAI;TKNQAVKEQQELLM;VIKPLLPKPKSKQ 6 6.8 1.0037 -1.1084 0 0 0 0 0 3.10874 0 9.02334 0 0 6.96809 0 0 4.88601 0 A0A8C0M6M3 A0A8C0M6M3_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] GEKPYECNECGKAYTQ;HSATALISFSTTSFT;SSLTQHQRIHTGE 3 11.7 0.94613 0.082531 14.7037 0 0 7.13432 0 0 0 0 0 0 0 0 14.5294 0 0 A0A8C0M6M7 A0A8C0M6M7_CANLF Lymphocyte expansion molecule LEXM Canis lupus familiaris (Dog) (Canis familiaris) KDFLEQLQEKPCSTRGLLSSGG;PFTKGRCPPTV;PVGVGHYLNTWLAETKDHR;THWGRCPRN;YLNTWLAE 5 15 1.001 -0.9337 0 0 0 0 9.57616 0 0 9.57465 0 0 0 0 0 0 0 A0A8C0M6P9 A0A8C0M6P9_CANLF RNA helicase (EC 3.6.4.13) DDX41 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] PLRQRRQLLLQKLLQRRRK;PVSARVAG;VLHCGDESMLDI 3 6 0.9865 -0.39303 0 7.41109 0 0 0 10.9069 0 7.51602 0 0 0 0 0 0 0 A0A8C0M6R4 A0A8C0M6R4_CANLF "ST3 beta-galactoside alpha-2,3-sialyltransferase 4" ST3GAL4 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] AADKLLNL;REDSFYFPIPEKKE;VIRLNNAPV;VLVVMVWYSI 4 12.5 1.0036 -1.9658 0 0 8.6494 8.22636 0 0 0 0 0 0 0 0 0 6.72137 0 A0A8C0M6R8 A0A8C0M6R8_CANLF F5/8 type C domain-containing protein DBNL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] EDDYYDGAWCAE;HYDDMDYYFGPP;LESETREDDL;MNGNRPIPHIDPS;NHGVKTASGGD;RGHRGHPGGLGGVGDGDL;YEDFPDLNSVL 7 6.7 0.99205 -0.18479 0 0 11.0666 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M6T0 A0A8C0M6T0_CANLF LEM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020]; nucleus [GO:0005634]; organelle envelope [GO:0031967] LDRAAPGPD;RDVYRNKLRRLRGE;TDKFCQAKQKAALLE 3 7.6 1.0033 -1.0255 0 9.80912 0 0 0 0 0 0 0 0 0 5.85255 0 0 0 A0A8C0M6T7 A0A8C0M6T7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RPVSPLSPAPL;SLIRPARPV 2 15.5 1.0037 -1.1047 0 0 0 0 0 0 0 0 4.60395 0 0 0 0 0 0 A0A8C0M6T9 A0A8C0M6T9_CANLF Integrin subunit beta 1 binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025] cell periphery [GO:0071944]; cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; ruffle [GO:0001726] integrin binding [GO:0005178] AICKVLSTAFDSVL 1 9.4 0.94364 0.061061 0 0 0 0 0 0 0 0 0 0 0 6.73917 0 0 0 A0A8C0M6U8 A0A8C0M6U8_CANLF WD repeat domain 19 WDR19 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary retrograde transport [GO:0035721] cilium [GO:0005929] AYENAKQWNSVI;FNLAQDLYLASSCPVAA;GVIQYFYIE;ITGDHKEHDELCL;LENMKQFSEAAQ;LLWSKIGSVLAVGTVKG;LYFARSNH;NQEGDTIRQ;PDTSETEE;YLAVTGADHI 10 8.5 0.99793 -3.3369 0 0 0 0 10.5003 0 11.77 0 10.3205 6.46058 0 0 0 0 0 A0A8C0M6W1 A0A8C0M6W1_CANLF Complement component C9 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218] CNGDNDCGDFSDE;CNGDNDCGDFSDEDDC;CNGDNDCGDFSDEDDCE;CNGDNDCGDFSDEDDCES;CNGDNDCGDFSDEDDCESD;CNGDNDCGDFSDEDDCESDP;DCGDFSDEDDCE;DNDCGDFSDEDDC;DNDCGDFSDEDDCESDP;EDDCESDP;NGDNDCGDFSDEDDCE;TTTFLDDIKALPSTYEKGEYF;VGDRRQCEPASPAPG 13 10.1 0.98741 -0.47778 8.18294 0 0 7.38569 0 0 6.3964 0 7.43863 4.57459 5.96449 0 8.36733 6.14995 5.35558 A0A8C0M6X4 A0A8C0M6X4_CANLF Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) Canis lupus familiaris (Dog) (Canis familiaris) mast cell degranulation [GO:0043303]; prostaglandin biosynthetic process [GO:0001516] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791] isomerase activity [GO:0016853]; small molecule binding [GO:0036094] LGGGQVRPINRGLSSSLC 1 6.5 0.97215 0.048313 0 0 0 0 8.85019 0 0 0 0 0 0 0 0 0 0 A0A8C0M6X8 A0A8C0M6X8_CANLF IPT/TIG domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PLPRERRRRRRRRDGPGPRPGPGE;SLRLPLPRERRRRRRRRDGPGPRP 2 2.7 0.9467 0.082605 0 5.74892 0 0 0 0 0 0 0 0 5.6414 0 0 0 0 A0A8C0M6Y5 A0A8C0M6Y5_CANLF Calsequestrin CASQ2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881] sarcoplasmic reticulum lumen [GO:0033018]; Z disc [GO:0030018] calcium ion binding [GO:0005509] DDDDDDGNNSDEESNDDS;DDDEDDDDDDGNNSDEE;DDDGNNSDEESNDDSDDDGP;DDDNEEGDDGDDDEDDDDDD;DDEDDDDD;DDGDDDEDDDDDDGN;DDGDDDEDDDDDDGNN;DDGNNSDEESNDDSDDD;DEDDDDDD;DEDDDDDDGNNSDEESNDDSDDDG;DGDDDEDDDDDDGNN;DNEEGDDGDDDEDDDDDDG;DNEEGDDGDDDEDDDDDDGNN;EDDDDDDGNNSDEES;EDDDDDDGNNSDEESNDDSDDDG;EDDDNEEGDDGDDDEDDDDDDGNN;EGDDGDDDEDDDD;EGDDGDDDEDDDDDD;EGDDGDDDEDDDDDDGNNSDE;GDDDEDDDDDDGNNSDEES;GDDGDDDEDDDDDDG;GKINTEDDDNEEGDDGDDDED;INTEDDDNEEGDD;LPTAEELEDWI;LSGKVKGDF;NEEGDDGDDDEDDDDDDGNNS;NEEGDDGDDDEDDDDDDGNNSD;NTEDDDNEEGDDGDDDED;VAFAERSDPD 29 13.8 0.97473 0.048206 0 0 0 0 0 0 0 3.73129 0 0 0 0 0 0 0 A0A8C0M6Y9 A0A8C0M6Y9_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] LETEDERVVFEAILQ;REEGLEGELQRGGPS;SAYRFDCETNQ;VLAASSRYFEAM 4 8.1 0.99273 -0.55382 0 0 0 0 12.6609 0 0 0 6.66945 0 0 0 10.913 0 0 A0A8C0M705 A0A8C0M705_CANLF Neuropeptide Y Canis lupus familiaris (Dog) (Canis familiaris) feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218] extracellular space [GO:0005615]; neuronal dense core vesicle [GO:0098992] neuropeptide hormone activity [GO:0005184]; neuropeptide Y receptor binding [GO:0031841] AGAHPSDRRPGTAQ;ALRHYINLITRQRY;GVTERDRPRPLLPPRGSA;LQKRRLARLRPRPPSP 4 12.2 0.99729 -0.10832 0 9.34203 0 0 0 0 0 0 0 0 0 0 6.80555 0 0 A0A8C0M709 A0A8C0M709_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;HIDQWNKIE;KNRHIDQWNK;MDAFLESHKL;MNEKGEITTNT 5 4.8 0.98759 -0.35067 10.5829 0 0 0 0 0 0 0 0 3.99014 0 0 0 0 0 A0A8C0M715 A0A8C0M715_CANLF FCH and double SH3 domains 1 Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] SPTAEDAELSDFEECEETGE 1 3.5 0.96408 0.048688 0 0 6.6134 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M718 A0A8C0M718_CANLF TIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GAIVSELCHALSSSHC;SLREQRRA 2 5.8 0.99206 -0.2081 0 0 0 7.55198 7.05409 0 0 0 9.7239 0 7.67624 0 0 0 6.75716 A0A8C0M738 A0A8C0M738_CANLF Kallikrein 1 KLK1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] LGHYNLFEHEDTAQFVQ 1 6 0.97303 0.046736 0 0 6.77558 0 0 0 0 0 0 0 0 0 5.9054 6.29609 0 A0A8C0M744 A0A8C0M744_CANLF DUF4585 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GSSIVSTSKALNGIGMEEL;TDLRGCWS;VAPALGAG 3 3.2 1.0033 -2.064 0 11.2494 0 0 0 0 13.8889 9.04535 9.88519 3.3444 0 0 0 0 0 A0A8C0M747 A0A8C0M747_CANLF DMAP1-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAVDVRAWPP;GAGWNAGDITQKGYE;GAPVSEYPFV;VPMPSKRR 4 2.7 0.95192 0.053899 9.03441 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M785 A0A8C0M785_CANLF Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) DNASE1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; zymogen granule [GO:0042588] actin binding [GO:0003779]; DNA nuclease activity [GO:0004536] VGVPPSRGTGGG;VLDSYQYDDGCEPCGNDT 2 8.4 0.99128 -0.27613 0 0 0 0 0 8.35231 0 0 0 0 0 0 0 0 0 A0A8C0M793 A0A8C0M793_CANLF Dynein regulatory complex protein 12 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EMCRQCRALQKEMETHRRQQEEEV;KLETCQREAEAAQ 2 19 0.99662 -0.10963 0 0 0 0 0 0 0 0 0 0 0 6.36045 10.7253 0 10.4646 A0A8C0M7A4 A0A8C0M7A4_CANLF POU domain protein POU4F1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration in hindbrain [GO:0021535]; cellular response to cytokine stimulus [GO:0071345]; cellular response to estradiol stimulus [GO:0071392]; central nervous system neuron differentiation [GO:0021953]; habenula development [GO:0021986]; innervation [GO:0060384]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; mesoderm development [GO:0007498]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peripheral nervous system neuron development [GO:0048935]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoclast differentiation [GO:0045672]; proprioception involved in equilibrioception [GO:0051355]; regulation of cell cycle [GO:0051726]; regulation of neurogenesis [GO:0050767]; sensory system development [GO:0048880]; suckling behavior [GO:0001967]; trigeminal nerve development [GO:0021559]; ventricular compact myocardium morphogenesis [GO:0003223] chromatin [GO:0000785]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; RNA polymerase II transcription regulator complex [GO:0090575] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]" GGGGGGPG;LQAWLEEAEGAQREKM;PGGGGGGG 3 7.9 0.96407 0.049233 0 0 0 0 0 0 9.95063 0 0 0 0 0 0 0 0 A0A8C0M7A9 A0A8C0M7A9_CANLF Transmembrane protein 63A TMEM63A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium-activated cation channel activity [GO:0005227]; nucleic acid binding [GO:0003676] CCCEVPGCEWE;DEPSTHPADP;LTSLDFFF;QSKAVSMRERLGIGDQ;VPGCEWEDAIS 5 5.3 1.0031 -1.3841 7.42417 0 7.68559 0 0 0 0 0 0 0 0 0 0 0 13.2697 A0A8C0M7B5 A0A8C0M7B5_CANLF E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher) MAEA Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte maturation [GO:0043249]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; GID complex [GO:0034657]; nuclear matrix [GO:0016363] actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KDLLDPARWRMLIQQ;TLSSCPAVDSVV;VGDFPRPRPRLRPPW 3 8.6 0.95088 0.053874 0 0 0 0 0 9.25642 0 0 0 0 0 0 0 0 10.2469 A0A8C0M7D4 A0A8C0M7D4_CANLF Electron transfer flavoprotein subunit beta CLDND2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] electron transfer activity [GO:0009055] DVDMEVDL;GVGKSSEG;KVEDQKPVAEREGVE;VDMEVDLE;VRLKLPAVVTADLRLNEPRYATL 5 14 1.0029 -2.3114 0 0 0 7.3672 0 12.1995 13.9021 13.8972 13.883 0 7.24251 0 0 13.0738 0 A0A8C0M7G1 A0A8C0M7G1_CANLF Alanine--tRNA ligase (EC 6.1.1.7) AARS1 AARS Canis lupus familiaris (Dog) (Canis familiaris) alanyl-tRNA aminoacylation [GO:0006419] cytoplasm [GO:0005737] alanine-tRNA ligase activity [GO:0004813]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] DLFVPYFE;MALELLTQE;TGRGYVLRRIL;VLATAVIPQWQKDEFRENLKSLK;WNLVFIQY 5 6.3 0.9988 -3.2683 0 0 0 0 8.96128 2.09255 8.74271 0 0 12.7361 0 0 0 0 0 A0A8C0M7J2 A0A8C0M7J2_CANLF E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; protein ubiquitination [GO:0016567]; regulation of signaling [GO:0023051] calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; ubiquitin-protein transferase activity [GO:0004842] AHNNIEMAKNI;ESENEEDGYDVP;GAGGGGGG;GGGGGGSG;PNYEDDDDERADDSLFMMKELAGA;SPNYEDDDDERADDS;SVGTDTRPQRRPLPC;VDTSMNVN 8 9.6 1.0025 -1.1468 0 0 0 0 0 0 12.4912 8.84276 0 0 0 5.48317 7.1126 4.96662 0 A0A8C0M7J3 A0A8C0M7J3_CANLF NACHT domain-containing protein NLRC5 Canis lupus familiaris (Dog) (Canis familiaris) AELGAAPDLQGNAI;DLSNNQFGEEDTEV;DVSIRDLFSTRA;GGTRLAESLTLCRH;HVTLNSRWVLRT;LGDEAAAELA;MDHVSFQLGTTNLWSWLVR 7 5.4 1.0021 -1.0139 0 0 13.3122 0 0 0 15.4338 0 11.7518 9.20494 0 0 0 0 11.4488 A0A8C0M7J6 A0A8C0M7J6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPA;EVQLVESGGDLVKPAG;LVESGGDLVK;LVESGGDLVKPA;VESGGDLVKPAGS;VRQAPGKGLQ 13 32.5 0 28.76 10.8305 13.1546 13.5396 12.4222 12.5182 13.1779 14.091 14.8898 13.7932 14.4946 14.6016 13.287 12.4915 13.8732 12.5066 A0A8C0M7J7 A0A8C0M7J7_CANLF Solute carrier family 22 member 15 SLC22A15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AIANGFSP;DRSYKVSAASSFFFSGV;GIIAPFIPS;RWDLAELLPNQ 4 8.2 1.0029 -1.3446 0 9.66653 0 0 0 0 0 0 9.73149 0 0 0 0 0 8.69905 A0A8C0M7L9 A0A8C0M7L9_CANLF RNA binding motif protein 27 RBM27 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; RNA binding [GO:0003723] DALKSWLAK;DDDDEDEDEYESRSW;IPFPPPPPGL;LEKQIECQKMLI;PPLLAARLVPP;RRCRDYDERGFCVLGDLCQFDHGND;RTREKKREDGKWRDYDRYYERNELY;SQLQVEAARLGILPVGR;SSYVPVSAPPPSSSEQYSSGAQSIP;TSIGYHTS;VLEPDSRKR;VSSPTPLVPDTYEPD 12 17.4 1.0006 -2.809 8.17153 10.2702 8.61202 0 4.54541 0 0 0 8.4138 8.74886 0 7.73843 9.21437 4.06186 0 A0A8C0M7M1 A0A8C0M7M1_CANLF Coiled-coil domain containing 27 Canis lupus familiaris (Dog) (Canis familiaris) FSKSACEFNYL;RQVDFQESQLQQVNTENNTLQK;SYLQPCPG;VDKEGKGP 4 5.7 1.0039 -1.1044 0 0 7.79565 6.82757 0 7.43937 0 0 0 0 0 0 0 0 0 A0A8C0M7N6 A0A8C0M7N6_CANLF Peroxiredoxin-5 (EC 1.11.1.24) Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxidative stress [GO:0034599] peroxisomal matrix [GO:0005782] thioredoxin peroxidase activity [GO:0008379] KKGVLFGV;QEPVTEQL;VEPDGTGL 3 9.7 1.0022 -1.8811 0 0 0 0 0 0 0 0 0 10.2064 0 7.50764 0 0 0 A0A8C0M7P4 A0A8C0M7P4_CANLF DnaJ heat shock protein family (Hsp40) member A3 DNAJA3 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457]; response to heat [GO:0009408] ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] EIFITFRVQ;TEPNVPADIFFWHLQ 2 4.9 1.0024 -1.0216 0 0 6.72969 6.90063 0 0 0 10.18 9.24603 0 0 6.47588 6.91874 7.30278 0 A0A8C0M7P6 A0A8C0M7P6_CANLF Eukaryotic translation elongation factor 1 gamma Canis lupus familiaris (Dog) (Canis familiaris) translation elongation factor activity [GO:0003746] LCWKNLSTSTPMRTLSLWHCRI;QELAFPLSPD 2 10.6 0.97634 0.047946 0 0 10.365 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M7Q5 A0A8C0M7Q5_CANLF Kelch like family member 32 KLHL32 Canis lupus familiaris (Dog) (Canis familiaris) GVTSLGLKQALEFAY;HYLIQELNSFNYLDLYRLAD;RCNFNLLTGQN;SIYAQPVWQTRRT 4 9.5 0.98746 -0.46642 0 0 0 0 0 0 0 0 0 8.98003 0 7.93905 0 0 0 A0A8C0M7R1 A0A8C0M7R1_CANLF SLAIN motif family member 1 Canis lupus familiaris (Dog) (Canis familiaris) CASTGGGSG;FSSIRECRRSPSTQYFPSNNYQQQ;GPEPGGAGTPPGGAPAPPSPPPT;GTFCLPSPAPSLLCSLAQ;NRTNGDKLRRSMPNLARMPS;SPAFPGTFCLPS;VGLMCPTCENSD 7 17.8 0.94151 0.05044 0 0 6.56177 5.8749 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M7R2 A0A8C0M7R2_CANLF Synaptotagmin Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488] axon [GO:0030424]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905] ATGTELRHWSDMLA;FSYVTFLLSPPW;GKRLKKKKTTVKKKTL;QNGKRLKKKKTT;QNGKRLKKKKTTVKKKTLNPY;RLKKKKTTVKKKTLNP;VGSNATGT 7 12.4 1.003 -1.5241 0 8.33141 8.46406 0 4.84031 6.34731 0 0 10.5848 6.08194 0 0 0 0 8.89227 A0A8C0M7R4 A0A8C0M7R4_CANLF Potassium channel domain-containing protein KCNK2 Canis lupus familiaris (Dog) (Canis familiaris) stabilization of membrane potential [GO:0030322] membrane [GO:0016020] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] IEYLDFYK 1 2.2 0.9924 -0.18061 0 0 0 0 0 0 0 0 0 0 0 10.8353 0 0 0 A0A8C0M7R5 A0A8C0M7R5_CANLF Peripheral myelin protein 22 PMP22 Canis lupus familiaris (Dog) (Canis familiaris) myelin assembly [GO:0032288] plasma membrane [GO:0005886] GGGGGGGG;PGGGGGGG;PPECSCCC 3 7.7 1.0038 -1.1044 0 0 0 0 0 3.22688 0 0 0 3.90188 0 0 0 0 0 A0A8C0M7R7 A0A8C0M7R7_CANLF Stonin-2 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737] EDKTDVRK;SESSSGENHVAD;SGDIWLMFPR 3 3.1 1.0039 -0.82227 0 9.13661 0 0 0 0 0 0 0 0 0 0 0 9.66139 13.1198 A0A8C0M7U6 A0A8C0M7U6_CANLF Alpha-mannosidase (EC 3.2.1.-) Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] KCWALTRGFGANVGP;SLLVDNVKERATWFRTPH;VYTTVVEQLMLQKQRRFI 3 5.1 0.99568 -0.092269 0 10.9537 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M7W2 A0A8C0M7W2_CANLF GOLD domain-containing protein TMED9 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] EQIQKEQNYQRWREERFRQ;GAGLGRVIRALLLLL;RVRQLVEQVEQIQKEQNYQRWREER 3 18.3 0.98587 -0.23536 7.43954 0 0 0 0 0 0 0 0 0 0 0 5.58877 0 0 A0A8C0M7W9 A0A8C0M7W9_CANLF "Spectrin alpha, non-erythrocytic 1" Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516] DLQLFYRDTEQVDNW;FEEFQTDMAAHEERVNEVNQFA;GEPDPEFEAI;HEAFETDFTVHKDR;IRVYQYEVGDDL;KKFDDFQKDL;PLCIAYRRVI;QEQHPEEETI;QKKFEEFQTDMAAHEE;QVDNWMSKQEAFLLNEDLGD;QYEQCMDLQLFYRDT;SYRFQFFQRD;TNVQNLQKKHAL;VEEEEAWINEKM;VGLAQQWDQL;YRDTEQVDNWMSKQEAFL 16 7.1 0.98787 -0.23425 0 0 0 0 0 0 0 0 10.6334 0 0 0 0 0 0 A0A8C0M7X5 A0A8C0M7X5_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; SCF ubiquitin ligase complex [GO:0019005] DARAQPQLSEHALETK;YHSTSTLMCAHCNRET 2 4.2 0.99796 -0.10378 0 0 8.82963 0 0 8.17627 0 0 0 0 0 0 0 0 6.52058 A0A8C0M7X8 A0A8C0M7X8_CANLF Rho guanine nucleotide exchange factor 16 ARHGEF16 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AARRDPQLLSAP;ACPLPLSQQPGPCRPESP;AMKGLGAPSGDRGPSQ;GRKRAHKGSFKDDPGF;LVLEQEDGWFY;PASGLPMVRGSLQ;SLDDMDVDMGSE 7 12.4 1.0031 -0.98494 10.3106 0 9.51284 0 0 0 9.52256 0 0 0 0 0 0 0 0 A0A8C0M7X9 A0A8C0M7X9_CANLF Synaptosome associated protein 91 SNAP91 Canis lupus familiaris (Dog) (Canis familiaris) clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; synaptic vesicle [GO:0008021] "1-phosphatidylinositol binding [GO:0005545]; clathrin heavy chain binding [GO:0032050]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; SNARE binding [GO:0000149]" PSGGAAAAAAPAPP;TPPTTTSEIAT;VGIDKGDIPDL 3 4 0.99187 -0.28804 0 0 0 0 0 0 0 0 0 0 11.4666 0 0 0 12.4095 A0A8C0M7Y3 A0A8C0M7Y3_CANLF Transcription activation suppressor family member 2 TASOR2 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of gene expression, epigenetic [GO:0045814]" ALEIAEEVNVTSDFPFASLI;CGDGRNPKMEAE;FENSGILITDVNN;GVDSQPNTTSPKDKQKAIH;LSDQSVICHKSVYSTLE;LSLKQQPSP;LSVSKEDASLESSE;MEETWVPGDPPPMEAPSA;NDIFLNEYKTFYQEKK;NSTLESLEFSEIE;RIYANFTVTRELTD;SDHDSCGD;SGDPLQPVNVQNR;VYISKYSDYLHAR;YVTNSGGI 15 7.4 1.0027 -2.5763 9.01826 0 8.19244 8.96362 6.65921 9.86525 9.55624 11.9636 11.367 9.52184 11.2524 11.8153 9.87928 9.13625 11.8031 A0A8C0M7Y9 A0A8C0M7Y9_CANLF Cytochrome P450 (EC 1.14.14.-) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" YTPKLSQKYGSI 1 2.9 0.99377 -0.1296 0 0 0 0 0 0 9.2593 0 0 0 0 0 0 0 0 A0A8C0M7Z1 A0A8C0M7Z1_CANLF DNA helicase (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872] ARLPKRLVKKGKKLK;DDDDEEEEGGCEEEEDDHMEFCR;DEEEEGGCEE;EEDDHMEFCRVCKDGG;EEIGSHLPLGPQAPV;GVDDGDGYETDHQDYCEVC;IVRVELSQMQKKYYK;LGKKSKRRRK;NDMDEPPPFDYG;PKRLVKKGKKLKDDKQ;PRAYHLVCLDPELEKAP;SRTFGGGV;TVTIAPPL 13 10.8 1.003 -1.3371 0 0 0 0 0 0 0 0 0 0 0 0 0 9.2247 6.2474 A0A8C0M822 A0A8C0M822_CANLF Laminin subunit gamma 2 LAMC2 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576] CQPCQCNNNVDPSASGNCD;DPKCDCDPA;GGGACDPDTGDCYSGD;GGGGGGGG;GNGFRCLNCNDNTDG;GPNGFKSLAQEAVRLADSH;HAALTSCPACYNQVKIQ;PVYFVAPAKFLGNQQVSY;RSYQRGLRLL 9 10.9 1.0019 -1.2599 11.0684 0 4.47703 0 6.60512 7.10518 10.6224 9.8318 0 0 4.73844 0 10.7842 0 6.36217 A0A8C0M823 A0A8C0M823_CANLF "RAB, member RAS onco family like 6" RABL6 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] EVESEMALDAEFLDVY;GNYRDMGEHR;MGEHRVILPDDVRDFIDNLDR 3 6.1 0.98751 -0.35126 0 0 0 0 0 0 0 0 0 0 6.17788 0 0 8.30259 9.12658 A0A8C0M826 A0A8C0M826_CANLF FACT complex subunit SSRP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of chromatin organization [GO:1902275] FACT complex [GO:0035101]; nucleolus [GO:0005730] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491] EWEFEKLSDFFKTHYRLELMEK;IETKQGTQ;KKKKKVKVK;NDSSDDSGEETDESFNPGEEE;PGNFQGHSGAQCITCSYK;SFDFEIETKQGTQYT;SYDEYADSDEDQH 7 14.1 0.98813 -0.26487 0 0 10.8073 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M831 A0A8C0M831_CANLF EGF-like domain-containing protein LRP8 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] CDEDDDCSDNSDE;CDEDDDCSDNSDEDD;CDEDDDCSDNSDEDDC;CDGEEECPDGSDESEAT;CDGEEECPDGSDESEATCT;CDGEEECPDGSDESEATCTKQVCP;DDDCSDNSDED;DDDCSDNSDEDDC;DEAGCATSLGTCRGDEFQCGDGTCV;DEDDCPKKTCADSDF;DEDDDCSD;DEDDDCSDNSDEDDCPKKTCAD;EDDDCSDNSDED;EDDDCSDNSDEDD;EDDDCSDNSDEDDC;EDDDCSDNSDEDDCP;EDPDACSQICVNYKGYFKCECHPGY;IPSVWRCDEDDDCSDN;LLLLLLLP;LLLLLLLPLRLQ;LLLLLLPL;PVLLLLLLLPLR;PVLLLLLLLPLRLQHL;RCDEDDDCSDNSDEDDC;RCIPSVWRCDEDDDCSDNSDEDDC;RPLAPPVLLLLLLLPLRLQ;VLLLLLLLPLRL;VWRCDEDDDCSDNSDEDDCP;WRCDEDDDCSDNSDEDDCPKKTCAD 29 15.4 0.97804 0.035538 0 0 0 0 0 0 4.42048 0 0 0 0 0 0 0 0 A0A8C0M841 A0A8C0M841_CANLF Mediator of RNA polymerase II transcription subunit 28 (Mediator complex subunit 28) Canis lupus familiaris (Dog) (Canis familiaris) mediator complex [GO:0016592] KFLDIARQTECFFLQ 1 8.6 0.9912 -0.18551 0 0 0 11.8709 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M864 A0A8C0M864_CANLF TFIIS N-terminal domain-containing protein IWS1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EEEFTGFNQEDL;ELQRQKDSD;ESDDDSDG;ESEEPQQHQASD;PKSPASDSETED;PQKGPASDSE;VEMESSRFQGTS 7 8.8 1 -2.8345 11.8035 0 0 7.64068 0 0 0 0 0 0 0 0 6.54496 0 8.3583 A0A8C0M877 A0A8C0M877_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MKRN3 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GVEGWENAIEFV;IVKSCPQCRVTSNFVIPSEFWVEE;TKQVTCRYFLHGL 3 9.5 1.0018 -0.68209 0 0 0 0 0 0 11.853 0 0 0 0 0 10.9284 8.56853 0 A0A8C0M893 A0A8C0M893_CANLF Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog) Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; telomere maintenance via telomere lengthening [GO:0010833] shelterin complex [GO:0070187] telomeric DNA binding [GO:0042162] AEGSAAAAAAQPE;SETQPDEDEEEEEEEKVSP;VSPPEVGAAIKI 3 10.2 0.99456 -0.12693 0 0 0 0 0 6.06985 0 0 10.8928 0 0 0 0 4.73031 0 A0A8C0M8D3 A0A8C0M8D3_CANLF "Beta-1,4-galactosyltransferase 7" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] glycosyltransferase activity [GO:0016757] PQSSEPRHLPLFLPR 1 2.9 0.9524 0.053886 0 0 0 0 0 0 0 0 10.4216 0 0 0 0 0 0 A0A8C0M8F0 A0A8C0M8F0_CANLF Yip1 domain family member 1 YIPF1 IFT25 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport [GO:0042073] cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] TEGQLQNEEIMA 1 8.4 0.94212 0.05044 0 0 0 10.6782 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M8F1 A0A8C0M8F1_CANLF HMG box domain-containing protein CIC Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AFHPSPAA;ASAATSFPLGSGTFKA;CSRDGCMKESQRR;DEPAEACGP;EEDDEAQQQQ;GAGEGDKPEEEDDEAQQQQQ;KERVTDSESGDSSGEDPEG;MELRQWPQQ;PVGSFEAGAP;QALQELTQMVSGP;RKNSTDLDSAPEDPTSPKRKMRRR;SGGKSPPA;SLRRTLDQRRALVM;SPNKREKDHIRR;TAPGGPVI 15 7.1 0.9975 -3.4219 11.0217 11.2178 11.5611 0 0 0 12.7006 11.1762 12.4229 12.4503 0 0 11.2985 11.8541 12.7535 A0A8C0M8F7 A0A8C0M8F7_CANLF Protein kinase domain-containing protein MAP3K5 Canis lupus familiaris (Dog) (Canis familiaris) MAPK cascade [GO:0000165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] HCKKFFEMVNTITE;LDFGETTVLDRFYN;LLCAGHGA;LPDDKKGIHEWNFSASSVRGVS;LVQSEGQVASDMYCLVGRIY 5 5.7 1.0013 -0.70655 0 0 9.46444 0 0 9.38161 10.2776 0 0 0 0 0 0 7.16229 0 A0A8C0M8G3 A0A8C0M8G3_CANLF Rap-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] EATLTCIMQLL;GETVKYCVDVYTDWI;LLFLLQINDILLAPPTVQGG;LVTQRLNSQWR;RFTYGPSFPPFK;SEDIGASIFNGQK;TFLSLKLRLVNILIGA;WGGTQACEDDISRD 8 6.8 1.0032 -0.88561 0 0 0 0 8.58988 0 9.74121 9.77933 8.17857 0 10.8575 0 6.63462 0 0 A0A8C0M8K0 A0A8C0M8K0_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) circadian rhythm [GO:0007623]; DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] SALPHKLRIKAK;SVQVTNIQDWSLKSEHWHQKELHGK 2 9.5 0.97921 0.035538 0 0 0 0 0 0 0 9.29579 0 0 0 0 0 0 0 A0A8C0M8K9 A0A8C0M8K9_CANLF HMG box domain-containing protein UBTF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DEDEDDDEDDDEDED;DEDEDDDEDDDEDEDNES;DEDEDDDEDDDEDEDNESE;DEDEDEEEEDDENGDSSEDG;DEDEDNESEGSSSSS;DEDEEEEDDEN;DEEDEDEDEEEEDDEN;DEEDEDEDEEEEDDENGDS;DENEEDDEDEDDDED;DESEDGDENEEDDEDEDDDEDDDE;DKKRLKWIHKAL;DQKKKDYEVELL;EDDDEDEDNESE;EDDDEDEDNESEG;EDDEDEDDDEDDDE;EDEDEEEE;EDEDEEEEDDENGDSSEDGGDSSE;EDEEDEDEDEEEEDDENGDSSE;ENEEDDEDEDDDEDDDEDEDNESE;ESEDGDENEEDDEDEDD;ESSSEDESEDGDENEEDDEDEDD;GDENEEDDEDEDDDED;GDSSEDGGDSSESSSEDESEDGD;GDSSEDGGDSSESSSEDESEDGDEN;NEEDDEDEDDDEDDD;NEEDDEDEDDDEDDDEDEDN;PDRWSQEDMLT;SEDGDENEEDDED;SEDGDENEEDDEDEDDD;SEDGDENEEDDEDEDDDEDD;SESEEDDEEDEEDED;SESEEDDEEDEEDEDED;SESEEDDEEDEEDEDEDEE;SESEEDDEEDEEDEDEDEEEED;SKSESEEDDEEDE;SKSESEEDDEEDEEDED 36 14.5 1.0029 -1.6609 9.49482 14.8917 9.1602 0 3.51513 8.59597 9.08781 11.3678 6.72301 8.97013 6.60055 8.20467 7.19574 7.98851 8.77824 A0A8C0M8L1 A0A8C0M8L1_CANLF Cadherin domain-containing protein PCDH7 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ESETPSSKSSSGPR;GGGGGGGE;GGGGGGGG;HYKSSSPLPTV;PGGGGGGG;SIGSDHCSEYSCQ;TVILIILIVVMARY;TVVATVLAT 8 7.4 1.0029 -0.84934 0 0 0 6.11076 0 0 12.5933 5.50449 7.15987 0 0 0 12.1216 11.5303 0 A0A8C0M8M0 A0A8C0M8M0_CANLF Olfactory receptor OR10AG67 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HYPLIMNHKMCIQLAVGSW;VNLWTQDRSI 2 9.3 0.95029 0.049902 0 0 0 0 0 0 7.53683 0 0 4.02192 0 0 0 0 0 A0A8C0M8M6 A0A8C0M8M6_CANLF PID domain-containing protein DAB2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] EEEKKKMEEANK;KKKMEEANKAVENG;MMKLKGMAAAGRSQGQ;SVVGYAHL;VGYAHLRLRGSPGV 5 6 1.0033 -1.5199 0 0 10.0076 9.93556 10.1126 10.0182 0 0 0 10.726 11.2008 11.05 0 0 0 A0A8C0M8P0 A0A8C0M8P0_CANLF UBC core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] PEKWNTNYTLSS 1 5.9 0.95104 0.05044 0 0 5.83018 0 0 0 0 0 0 0 0 0 4.88118 0 0 A0A8C0M8P9 A0A8C0M8P9_CANLF Gap junction protein GJC1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] LEETEEDHEEDPMMYPE;REIKMAQERLDLAIQAYSHQNNPHG;VGKIWLTVLIVFRIVL 3 14.6 0.94562 0.084771 0 0 0 0 5.25001 0 0 0 0 0 0 6.95849 0 0 0 A0A8C0M8R3 A0A8C0M8R3_CANLF Cytosolic carboxypeptidase 2 (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cell projection [GO:0042995]; centriole [GO:0005814]; cytosol [GO:0005829] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] ATKRGRATMTVYPS;ESFPCIWYTRNMVK;GQDMDLEGNWSDIS;IFVFKVVP;LCRSLAGN;PERAGFAS;SNGSWIMKGFLDFI;VGEEKGTVVYQLDS 8 11.4 1.0034 -2.448 0 0 9.83525 6.66306 7.96705 7.68356 0 0 0 0 0 8.8437 7.9755 0 0 A0A8C0M8S5 A0A8C0M8S5_CANLF cAMP regulated phosphoprotein 21 ARPP21 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] IVKSESLDEEEKLELQR;NTRIPEQRFCEHLKDEKGE;QSVQYPAVSFPP 3 5.7 1.0026 -0.79274 0 0 0 0 0 0 0 0 9.87203 0 0 0 0 0 9.85856 A0A8C0M8U7 A0A8C0M8U7_CANLF Stimulator of interferon genes protein STING1 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471] "2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]" SIVPTSSTLSQEPN 1 5.5 0.98996 -0.20112 0 0 0 0 0 0 0 0 0 0 0 0 10.4263 0 0 A0A8C0M8W1 A0A8C0M8W1_CANLF Heparan sulfate proteoglycan 2 HSPG2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; circulatory system development [GO:0072359] basement membrane [GO:0005604] calcium ion binding [GO:0005509] ACSQCQHNAAGEFCELC;AEGQTLDLNCLV;AGTYVCTGSNMFAMDQGTATL;AITAADAGFYLCVAT;ERCSCHGHTEVCEPETGTCQ;HVHGGSGPRVQVSPERTQV;LVFSYQLGSGEARLVSEDP;MNARGMVFGIPDGV;PAESRVSGISMDVA;PKDYICDGQEDCKDGSDELDCGPT;PNEFPCGNGHCALKLWHCDGDFDCE;SSGFIGCVRELRI;SSGSVASYIT;TLAPEGAPA;TSSSHVAE;VTNVCQSSRRFRDQIRLR;VTPADSGEYVCHVSNG 17 6.5 1.0032 -1.9448 7.18874 0 11.2388 6.75328 9.37725 0 0 8.9516 0 0 15.7561 0 8.74372 0 13.5963 A0A8C0M8Y4 A0A8C0M8Y4_CANLF Superkiller complex protein 8 (WD repeat-containing protein 61) SKIC8 Canis lupus familiaris (Dog) (Canis familiaris) Cdc73/Paf1 complex [GO:0016593] AGPVDAWTLAFSPD;LFKQEQAHDDAIW;SLDDLVKVWKWCD 3 18.7 0.9916 -0.13661 0 0 0 7.98607 0 0 0 0 8.33154 0 0 0 0 0 9.57667 A0A8C0M8Z3 A0A8C0M8Z3_CANLF LRRCT domain-containing protein CD180 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HNPLDCTCLNIHFITWYKEN;LVTVLLIFFIKFLLRWKYQHI;YKENLQKF 3 7.2 0.99361 -0.16496 0 0 0 0 0 0 10.9232 0 6.00092 0 0 0 0 9.7661 0 A0A8C0M920 A0A8C0M920_CANLF KIND domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin nucleation [GO:0045010]; cellular component assembly [GO:0022607]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] actin binding [GO:0003779] ASELKQLIHQQLSKM;EIILDFIRSRPPLKPVAAR;ENGLSAAQQVPVQRKKLLKAPTL;GVTSLTVE;KQSSRSLEEFCYPV;TVWEDQLSYLLSPALASYEFER 6 7.9 1.003 -1.7287 0 0 0 0 0 0 0 0 12.1127 9.95952 0 0 9.77633 0 9.04483 A0A8C0M956 A0A8C0M956_CANLF 60S ribosomal protein L32-like Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LVKPKFIKKRTKK;LVKPKFIKKRTKKFIR;TKKFIRHQSDRYVKIKRTWQ 3 22.2 0.85096 0.15742 0 6.28917 0 0 0 0 0 7.08076 0 0 0 0 5.60896 0 0 A0A8C0M966 A0A8C0M966_CANLF Chromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] PLAGAAGA;QPSPFLWEGGGL;WQPSPFLWEGGGLGHQ 3 3.3 0.9897 -0.5272 0 0 0 0 0 0 0 0 0 10.0881 0 0 0 0 0 A0A8C0M975 A0A8C0M975_CANLF Zinc finger protein 624 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IKSHLTVHQ;ITLSQLTLHQR;KDTESSKAIRPTS 3 3.9 1.0022 -1.3916 0 0 0 0 0 0 14.1786 0 0 0 0 0 0 0 0 A0A8C0M990 A0A8C0M990_CANLF Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78) Canis lupus familiaris (Dog) (Canis familiaris) dynein axonemal particle [GO:0120293] SNSNVPVLDSSESPQKHLGP 1 2.6 0.949 0.05015 0 0 10.099 8.24655 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M998 A0A8C0M998_CANLF Family with sequence similarity 171 member A2 FAM171A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAAADGVQRQ;HTIFLLTILAALALLVLILL;LAAVSVHL;QLAGAPLLHR;TIFLLTILAALALLVLILLCLLI 5 6 1.0015 -0.69947 8.63107 0 0 0 4.87499 9.6195 8.42492 8.83615 0 0 0 0 0 5.98274 0 A0A8C0M9A1 A0A8C0M9A1_CANLF Bardet-Biedl syndrome 7 protein homolog BBS7 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515] BBSome [GO:0034464] NDKFTLNKDDA;SESVTSIQGGCIGKDGYDEIV;TGLTTEPIHKESGPG 3 7.1 0.86424 0.17628 0 0 0 0 0 0 0 0 0 0 5.35776 0 6.71067 6.26422 4.54449 A0A8C0M9B2 A0A8C0M9B2_CANLF Rhodanese domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HNFCTAIFK;LLNSKKIML 2 16.2 1.0025 -1.1231 0 0 0 0 8.10392 0 0 0 0 0 0 0 0 0 0 A0A8C0M9C3 A0A8C0M9C3_CANLF Serpin domain-containing protein SERPING1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] FPVFMGRVYDPLV;GGGGGGPG;GGRGGGGG;GVEAAAASAVSV;GVEAAAASAVSVARNL;MGRVYDPLV;PVFMGRVYDPLV;SLPSDTRLVLLNAVYLS 8 10.6 0 1.2374 12.8688 12.8115 12.8168 9.45426 10.1795 11.1434 11.5299 10.882 12.7893 8.92917 0 11.8789 12.7399 13.0567 12.9904 A0A8C0M9C7 A0A8C0M9C7_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AASAGGVGAGVEDSS;IPFSVDEIVRMPVDS;LDLNIFDEINLMSLATGFDPMEV;QDLLYDLDLN;VGAGVEDSSQAAPGD 5 9.5 1.0019 -0.74223 0 0 0 0 0 0 0 11.6834 0 0 0 0 0 9.1765 0 A0A8C0M9D2 A0A8C0M9D2_CANLF Uncharacterized protein OSBPL8 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131]; lipid transport [GO:0006869] chaperonin-containing T-complex [GO:0005832] lipid binding [GO:0008289] EIKRLVVAYVSS;TDNSEVFWNPTPDIKQ;TFVVFLCHLL;VISTSSFIPHCVVLCGPVQGLV 4 6.4 1.0034 -0.86694 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.15046 A0A8C0M9E2 A0A8C0M9E2_CANLF AE binding protein 1 AEBP1 DBNL Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202] actin binding [GO:0003779] HPHRQCHH 1 1.9 1.0045 -1.1044 0 0 0 0 0 0 4.86463 0 0 0 0 0 0 0 0 A0A8C0M9G4 A0A8C0M9G4_CANLF EF-hand calcium binding domain 7 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] calcium ion binding [GO:0005509]; phosphoric diester hydrolase activity [GO:0008081] KVYMTTNEQCLKTTVEKLEVDS;VEFTSEGI 2 4.4 0.98773 -0.46189 0 9.95188 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M9G5 A0A8C0M9G5_CANLF Olfactory receptor OR9M1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIAPKLLVELISKEKTISYKG 1 6.8 0.97648 0.047248 0 0 0 0 7.04155 0 0 8.36842 0 0 0 8.3462 0 0 0 A0A8C0M9H7 A0A8C0M9H7_CANLF Free fatty acid receptor 1 (G-protein coupled receptor 40) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] VGGGGGLL 1 2.2 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 17.8203 0 A0A8C0M9K3 A0A8C0M9K3_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PGESLWRSAVQ;QIDLTQQKGPEE;RLSAPHPESDDGGGV 3 6.8 0.98601 -0.41256 0 0 0 0 0 0 0 11.8952 0 0 0 0 0 0 0 A0A8C0M9K5 A0A8C0M9K5_CANLF Importin N-terminal domain-containing protein TNPO1 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] DDDDDEIDDDDTI;GGRGGGGG;GVIQDFIFFCDAVA;HDEDGIEEEDDD;KPEYIQMLMP;LAAELRGPVP;LLPHILPLLKELLFHHEW 7 8.4 1.0028 -1.3403 0 11 5.86111 0 0 6.29558 0 0 7.00461 0 0 4.97934 0 10.9078 0 A0A8C0M9L4 A0A8C0M9L4_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSQIHHLKQHSLTHKGV 1 2.6 0.98345 -0.24789 0 0 0 0 0 0 0 0 10.6583 0 0 0 0 0 0 A0A8C0M9M4 A0A8C0M9M4_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LDSALEKEKLARKLAS;LHDLSGGP;TFERNLETLQ 3 3.4 1.0033 -1.5613 0 0 0 11.0755 7.27622 0 0 0 0 0 0 0 8.97327 0 0 A0A8C0M9N3 A0A8C0M9N3_CANLF Cytochrome P450 family 27 subfamily C member 1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ALCHYATSYE;EFFWKDGFGRIHEIQ;GVATILYESR 3 6.5 1.0018 -0.67699 0 0 10.1849 0 0 0 0 0 0 10.0102 0 0 0 0 0 A0A8C0M9N6 A0A8C0M9N6_CANLF E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher) MAEA Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte maturation [GO:0043249]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; GID complex [GO:0034657]; nuclear matrix [GO:0016363] actin binding [GO:0003779]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KDLLDPARWRMLIQQ;TLSSCPAVDSVV;VGTRRWCARGKP 3 7.9 0.99727 -0.10264 0 0 0 0 0 7.30633 0 0 0 0 0 0 0 0 6.06908 A0A8C0M9N9 A0A8C0M9N9_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CDCTSGSM;EEDDEEETEEEEEAVAEVG;EEEEEEEEEDDEEET;EEQNGLEEEEEEEEEED 4 6.4 1.0018 -0.95488 0 5.53907 0 4.45595 6.02959 0 0 0 0 0 0 0 0 0 0 A0A8C0M9P9 A0A8C0M9P9_CANLF Cysteine rich tail 1 Canis lupus familiaris (Dog) (Canis familiaris) AHHCCCCPCCSCCH;AHHCCCCPCCSCCHCP;CCCCPCCSCCHCPRFC;CCCPCCSCCHCP;CCCPCCSCCHCPRFC;CCSCCHCPRFCRCHSCCCI;CPCCSCCHCP;DDIAHHCCCCPCCSCCH;DDIAHHCCCCPCCSCCHC;DDIAHHCCCCPCCSCCHCP;DIAHHCCCCPCCSC;DIAHHCCCCPCCSCC;GDDIAHHCCCCPCC;GDDIAHHCCCCPCCSC;GDDIAHHCCCCPCCSCCHC;GRGDDIAHHCCCCPCCSCCHCP;HCCCCPCCSC;HCCCCPCCSCC;HCCCCPCCSCCH;HCCCCPCCSCCHCPRFC;HHCCCCPCCS;HHCCCCPCCSC;HHCCCCPCCSCC;HHCCCCPCCSCCH;HHCCCCPCCSCCHCP;PCCSCCHCPRFCRCHSC;RPPMGRGDDIAHHCCCCPCCSCCH 27 26.8 1.0034 -1.5522 5.86466 10.9911 9.14101 8.1822 6.20328 0 8.34806 0 6.69139 3.3209 6.42843 5.1066 12.1445 7.26322 8.27291 A0A8C0M9Q3 A0A8C0M9Q3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] transmembrane signaling receptor activity [GO:0004888] ASFNLFLTPEHSGSYACEAD;PPILYRFYYDDVFL;SCEADNGLGAQCSEAVTLSISGG;VISLHPPWTVFF;YQFYHGDVL 5 9 1.0032 -0.88057 7.57334 0 9.98371 0 0 0 0 9.54098 8.4302 0 0 0 0 0 3.52331 A0A8C0M9V6 A0A8C0M9V6_CANLF RWD domain-containing protein RWDD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] AAGGGGGG;DLELEDDEDDPDYNPADPE;ESESGARWSLVLSE;GGGGGGGA;GGGGGGGG;MKEEEQAGKNKLSG;QEMDDLELEDDEDDPDYN;SLVLSENPPSF;SSGGCGAE 9 12.7 1.0018 -1.4084 0 10.1279 6.13299 7.66185 0 13.7729 5.29495 0 7.69481 0 0 0 0 0 0 A0A8C0M9W5 A0A8C0M9W5_CANLF KIAA1549 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASGPPPAG;EASRRVPNKIQLIAM;EFPVVDDLSS;ETTSYSGLSPVAR;GVVIPVLVVMVIVIIL;IPSTAPLV;LAKDELFLEQQNLSL;LSASSLVP;LVPEAIPSPLPTEPMFVGSSFTPTD;LVVMVIVIILYWKLCRTDKL;PCRGHHRFPDS;QRAAIILG;TRPCPSGGHLATPASPT;VEPSLVPEREPG 14 9.5 0.94853 0.05391 0 8.21014 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M9X0 A0A8C0M9X0_CANLF Glycosyltransferase 8 domain-containing protein 1 GLT8D1 Canis lupus familiaris (Dog) (Canis familiaris) UDP-glycosyltransferase activity [GO:0008194] AIYMDDDVIV;FYQQHSTIDPMWN;KAHEMITIPSL 3 7.7 0.99408 -0.05933 10.521 0 10.8774 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0M9X6 A0A8C0M9X6_CANLF Cadherin domain-containing protein PCDH7 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DEYGHSDSCWMPVR;GGGGGGGE;GGGGGGGG;HYKSSSPLPTV;PGGGGGGG;SIGSDHCSEYSCQ;TVILIILIVVMARY;TVVATVLAT 8 6.9 0.9347 0.060769 0 0 0 0 5.87922 0 0 0 0 0 0 0 0 0 0 A0A8C0M9Y5 A0A8C0M9Y5_CANLF Myotubularin phosphatase domain-containing protein MTMR10 Canis lupus familiaris (Dog) (Canis familiaris) ESRMYFRVSAHATP;EVSFVRKCIATDTSQY;KLEPVLLPGEI;LADEVDALSRTL;LDKTLPNI;SLRNGIISDPD;VGRRMPLWCWSH 7 11.8 1.0023 -1.7519 0 0 12.1794 0 0 0 11.9788 10.0584 0 0 0 11.498 9.21264 0 0 A0A8C0M9Z8 A0A8C0M9Z8_CANLF Amyloid beta precursor protein binding family B member 3 APBB3 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta binding [GO:0001540] DPHTFGLIADLGRQS 1 3.3 0.94503 0.076616 0 0 0 0 0 0 0 10.6019 9.83741 0 0 0 0 0 0 A0A8C0MA00 A0A8C0MA00_CANLF Quinoid dihydropteridine reductase QDPR Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" AGDGAARS 1 2.6 1.0038 -1.1044 0 0 0 0 0 0 12.9256 0 0 0 0 0 0 0 0 A0A8C0MA14 A0A8C0MA14_CANLF Transmembrane protein 87B TMEM87B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IFAELISAVKRTLARLLV;IFAELISAVKRTLARLLVI;IVFMVWTTKT;SLILIVIMFLWR 4 7.8 0.98778 -0.49417 0 6.13434 0 7.42559 0 0 0 0 0 0 0 0 0 0 7.77485 A0A8C0MA24 A0A8C0MA24_CANLF EFR3 homolog B Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659] plasma membrane [GO:0005886] GLAAGDAATRPPGGARPAEMYGV;LVDNIFPEDPED;QVVEKFQKAPFEEIAAHCG;RLVLAVQDVAQVN;SFVKFANIEE;SRFSEMCHSSHDDME;VKTNMEKLTFY 7 10.3 0.98988 -0.3056 11.9466 8.97983 0 0 0 0 0 0 8.8233 0 0 0 0 7.56948 9.05077 A0A8C0MA26 A0A8C0MA26_CANLF Olfactory receptor OR1X2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TLMWTCSG;TWTISYPHCLTQMYFLISFANL 2 9.6 0.98741 -0.46287 0 0 0 0 0 0 0 0 0 0 0 0 9.49823 0 0 A0A8C0MA39 A0A8C0MA39_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DAKILKILANRFQQHIKKIIHHD;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;QINPTPSRRRELIKIQA 6 10 0.93484 0.09248 0 3.94064 0 0 0 0 0 0 0 4.40837 0 0 0 0 0 A0A8C0MA65 A0A8C0MA65_CANLF Homeodomain interacting protein kinase 2 HIPK2 Canis lupus familiaris (Dog) (Canis familiaris) "adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cell population proliferation [GO:0008283]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; gene expression [GO:0010467]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; lung morphogenesis [GO:0060425]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; respiratory system process [GO:0003016]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; thyroid gland development [GO:0030878]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]" cytoplasmic stress granule [GO:0010494]; PML body [GO:0016605]; RNA polymerase II transcription regulator complex [GO:0090575] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; virion binding [GO:0046790] CFQHKNHTCLVFEMLEQNLY;EAETGIKSKEARKYIFNCLDDMAQV;ETGIKSKEARK;FQQQQPLNLSQAQQHITAER;ISQTQGLPAEYLL;LKYIRPVLQQVATALM;LPYEQTIIFPGSTGHIVVT;NVISCVTVHDSPY;TVATATTSTA 9 10.6 1.0023 -0.65099 0 6.96128 0 0 0 0 9.74088 11.1817 0 7.31741 0 0 0 0 0 A0A8C0MA84 A0A8C0MA84_CANLF Transcription elongation regulator 1 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase binding [GO:0070063] GDERVFFYNP;PGVLPGMAPP;RYLLLNPKERKQLLNYLDH;VSQTVSTPTTQDQ 4 4.8 1.0022 -0.76864 0 11.8528 0 4.71012 0 0 0 11.3815 0 0 0 0 10.1297 0 0 A0A8C0MA85 A0A8C0MA85_CANLF Mitochondrial ribosomal protein S24 MRPS24 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] GYSETLLSHF;NLDGEEHAAERTVEDVFLRKFMLGT;SAPAGRPRPDS 3 12.8 0.99668 -0.57786 0 0 0 0 0 0 0 0 4.24914 0 0 0 12.0717 0 0 A0A8C0MAA7 A0A8C0MAA7_CANLF Bridging integrator 1 BIN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; intracellular organelle [GO:0043229] FFAAKGLSPLLP;GFMFKVQAQ;LPKSPSQLR;LSLSPCPL;PSQTAEPG 5 6.2 1.0035 -2.2476 10.5741 0 0 0 0 8.15841 0 11.3827 10.4139 0 0 10.8238 0 0 0 A0A8C0MAB1 A0A8C0MAB1_CANLF Proteasome assembly chaperone 2 Canis lupus familiaris (Dog) (Canis familiaris) GVSARTARPHLPRRP;LSSSHSYHRNDLQLRSTP 2 8.7 0.95267 0.053886 0 0 0 0 0 0 8.42072 0 0 0 0 0 0 0 0 A0A8C0MAB7 A0A8C0MAB7_CANLF Toll like receptor 10 TLR10 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] ILDLNNNKIQTV;LDHYSFDYSNTVMRTIKLEHVQF;LNTTKLHIVL 3 5.6 0.98985 -0.21379 0 0 0 0 0 2.39616 10.3912 0 0 0 0 0 0 0 0 A0A8C0MAC5 A0A8C0MAC5_CANLF Amphiphysin AMPH Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle endocytosis [GO:0048488] plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] phospholipid binding [GO:0005543] ASHNASTESSASPQ;ASPNHTLAPASPAP;EASMKLTESLHEVY;EISVTTPSQNEVPEV;GAPSDSGP;GVDRNESQAIVLSRKHEVTAPS;KDESRISKAEEEFQKAQ;LVQPTDSSKSLSL 8 9.3 1.0027 -1.8519 9.3115 0 0 9.3716 0 11.7517 0 0 0 0 8.85421 0 9.24051 0 0 A0A8C0MAC6 A0A8C0MAC6_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] EYFLKVLIPSY;GQTNGGAE;VGAILGKGGKTLVEYQE 3 4.7 0.98892 -0.51861 0 0 0 0 0 0 0 0 8.68068 0 0 0 0 0 11.3099 A0A8C0MAF8 A0A8C0MAF8_CANLF Transaldolase (EC 2.2.1.2) TALDO1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] cytoplasm [GO:0005737] transaldolase activity [GO:0004801] CEVWLLLAGKRTWLCRAC;LDEKAFRWLHNED 2 8.8 0.98961 -0.21428 0 0 0 0 0 0 10.1403 6.2025 0 0 0 0 0 0 0 A0A8C0MAG2 A0A8C0MAG2_CANLF Tr-type G domain-containing protein HBS1L Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DEDFEDDDLYGQSVEDDYCIS;LEKRQGGKQLLNLVVIG;NVNKRTMH;NYDEDFEDDDLYG;TSIASSDVLDTVSKSVLPSH;WYKGLCLLEQ 6 13.5 1.0025 -1.165 0 0 0 0 0 0 0 5.00374 0 0 0 3.92979 4.6084 10.2529 11.6065 A0A8C0MAH0 A0A8C0MAH0_CANLF Vestigial like family member 4 VGLL4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] transcription coactivator binding [GO:0001223] DLLNYQYLDKMNNNIGI;SPTLTPVER 2 8.8 0.98676 -0.25994 0 0 0 0 0 0 0 0 0 0 9.52072 0 9.21931 0 0 A0A8C0MAH2 A0A8C0MAH2_CANLF phosphoacetylglucosamine mutase (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) PGM3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] metal ion binding [GO:0046872]; phosphoacetylglucosamine mutase activity [GO:0004610] DLVKKYKL;EYRSLKVDCANG;HLHHKAQEFDIGVYFEANG;TIEGYCQK 4 10.7 1.0022 -0.90663 0 0 0 0 0 8.66871 0 0 0 9.93961 0 9.0131 9.55169 0 0 A0A8C0MAH3 A0A8C0MAH3_CANLF von Hippel-Lindau tumor suppressor VHL Canis lupus familiaris (Dog) (Canis familiaris) ERLTQEHIENQ;EVGAEEVGPEES 2 10.5 0.98787 -0.4852 0 9.68555 0 0 0 0 0 0 0 0 0 0 9.2706 0 0 A0A8C0MAI4 A0A8C0MAI4_CANLF Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein KIAA1109 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAEEFEPISSDEGPGTYPG;DPLDKVLSVLIKKLGTAL;GHAESIQDPRTLPFKTH;IYYITEDMSIRIQDGFIIFRWWK;KENYFGEDDMYMD;LACLLEWGQTFVFHVV;LNIHRVHGQ;LPSEKTPTSVNQ;LSFTACMSDF;MALHKDIHMATK;PDIFSFVP;PWADRQRDCL;QRYQQLESVAVND;RKEWENKPVGIEVE;RMRSHGMTGA;SSSSFEQLSVP;TAAQSLKSPASIRS;TYEVCSRTTGQAAAE;VGGDGHKL;VGGTIDVNALE;VLSPLNVFV;VLWKMCGIDV;VMLTIDYTWHPIYPQ 23 6 0.99667 -4.2171 0 13.24 11.3013 11.5082 4.93149 10.8805 13.9021 0 13.6642 9.2436 6.32463 0 0 9.39508 13.8616 A0A8C0MAK0 A0A8C0MAK0_CANLF SMB domain-containing protein ENPP2 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] "hydrolase activity, acting on ester bonds [GO:0016788]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]" ATLWFHFN;EDNACHCSEDCLAKGDC;ESCNSSEDESQ;GVPEYLTNCVRPD;HRPDNEESCNSSEDES;LNHLLRTHTFR;LTILQWLTLP;PEEVTRPNYPGIMYLQ;SYSSCCHDFD;TRYDILYHTD;YLQSDFDLGCNCDD 11 12.8 1.0032 -2.2069 0 11.3914 3.93546 7.63125 0 8.52317 0 0 0 10.2262 0 9.2396 0 0 10.0699 A0A8C0MAN3 A0A8C0MAN3_CANLF Caspase recruitment domain family member 14 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] AEYLSQEEHGACS;ETAKLTECLAGAIGSLQEELS;PYSTTGAE;VPCLYGSL 4 5 1.0045 -1.0468 0 0 0 0 0 9.81477 0 7.64976 0 0 0 0 0 0 0 A0A8C0MAN5 A0A8C0MAN5_CANLF Zinc finger and BTB domain containing 26 ZBTB26 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EPQHSLINSTVENRVSEIEQ 1 4.5 0.96604 0.048658 0 0 10.6381 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MAP2 A0A8C0MAP2_CANLF Transcription termination factor 2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] DGPHATWKIISKAIDELH;EAHCVRNPRV;EVKKKQPL;LAWLLWRESQ;TKEEDKNVALTWLSKDG 5 5.7 0.98942 -0.21592 0 0 0 6.71658 0 0 0 0 0 0 0 0 7.61919 0 0 A0A8C0MAQ1 A0A8C0MAQ1_CANLF "G protein-activated inward rectifier potassium channel 4 (Cardiac inward rectifier) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)" KCNJ5 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] G-protein activated inward rectifier potassium channel activity [GO:0015467] EKGFYEVDYNTFHDTYETNTPSCC;VGCMFVKISQPKK 2 8.8 0.9897 -0.22367 0 5.54235 0 9.05694 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MAS4 A0A8C0MAS4_CANLF Adhesion G protein-coupled receptor F1 ADGRF1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ESNLSQPHCVF;FPLEDSSF;LNAFQGFF;LQNKGIYVLSHTG;NSSSPSYSKYATGI;SYRDSKEKRDLKNFL 6 7.9 1.0029 -1.9523 0 0 9.36427 0 0 0 0 0 9.46037 6.85885 10.1634 10.3009 0 0 0 A0A8C0MAX2 A0A8C0MAX2_CANLF Mitochondrial fission regulator MTFR2 Canis lupus familiaris (Dog) (Canis familiaris) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] mitochondrion [GO:0005739] AANEMKKQHPGDNSKTN;AFQEDDSFEKENRSWESSPFS;RIIGKILPLE 3 13.3 1.0041 -0.82193 0 0 0 0 0 0 0 0 0 8.95762 0 8.93805 0 3.16548 0 A0A8C0MAX5 A0A8C0MAX5_CANLF Histone deacetylase (EC 3.5.1.98) HDAC2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] NuRD complex [GO:0016581] histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872] EDSGDEDGEDP;MEIYRPHK;YAVNFPMRDGIDDESYGQIFKPIIS 3 9.4 1.0035 -1.0334 0 0 0 0 0 8.1498 0 9.40956 0 0 0 0 0 4.1504 0 A0A8C0MAX9 A0A8C0MAX9_CANLF RNA helicase (EC 3.6.4.13) DHX35 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] VLGHEVGYCIRFDDCTDPLATRI 1 3.6 0.97472 0.046463 0 0 0 0 8.94254 0 0 0 0 0 0 0 0 0 0 A0A8C0MAY9 A0A8C0MAY9_CANLF Anaphase-promoting complex subunit 2 TPRN Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] phosphatase binding [GO:0019902]; ubiquitin protein ligase binding [GO:0031625] AGLTGDSDGTGDLAVELSKTDPAS;DPVDADPG;EAQEEAEEEEEEEEEEE;ESAPGFPPASPG;GQDSEDDSGEPEDWVPDPVDA;GVEEGACPRPA;KSCLTKAGSS;LLLAWNTV;SDIISLLVSI;SEAQEEAEEEEEEEEEEEELS 10 7.2 0.99731 -3.433 8.58477 0 0 0 0 7.03056 8.46234 5.33328 10.8424 0 7.15755 0 0 5.87224 0 A0A8C0MB23 A0A8C0MB23_CANLF "MYB proto-oncogene, transcription factor" MYB Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] DIEMCDHDYDGL;EDDEDIEMCDH;EENRTDVQCQHRWQK;SDEDDEDIEMCDHD 4 11.1 0.95177 0.053887 8.76421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MB35 A0A8C0MB35_CANLF Otoferlin OTOF CIB4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] AGDLLAAF;EAYCPPRFPPQLEYYQ;ELTSSTEV;HTYRWLLLKLLLLMLLLLL;HTYRWLLLKLLLLMLLLLLLALF;HYHSLTGEGNFNWRYLFPFDYL;IDSNEILEIQ;KSSDIFVRGWLKGQQEDK;LLKLLLLMLLLLLLAL;LLLKLLLLMLLLLLLA;LLLKLLLLMLLLLLLAL;LLQIGPAGKADLPP;MKEQLRQQEVSGTDLE;NTDEVVLEDDDFFT;PSEIEDENGQRKPT;TDRNYFHLPYLERKPCIYMKSW;TYRWLLLKLLLLMLLL;VLEDDDFFTGE;WLLLKLLLLMLLLLLLALFLYSVP;WPVASNIDSNEILEIQI;YLWLGLSKQRKDFLC 21 10.7 1.0036 -2.3832 9.57056 11.5759 8.77873 0 9.49593 10.036 9.15644 0 5.04597 0 8.26627 8.234 10.5606 4.46669 10.9748 A0A8C0MB61 A0A8C0MB61_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YSPPPSPSVL 1 4.3 0.67636 0.29103 0 0 10.6739 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MB88 A0A8C0MB88_CANLF acid phosphatase (EC 3.1.3.2) ACP3 Canis lupus familiaris (Dog) (Canis familiaris) ILPPYASCHIMELYLE;PSLLACLE;TDVDRTLMSAMTNLA 3 9.5 1.0021 -0.6686 0 0 10.2058 0 0 0 0 0 0 0 0 11.4444 0 0 0 A0A8C0MB93 A0A8C0MB93_CANLF Transcription factor 4 TCF4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] ERLSYPSHSSADINSSLPPM;EVQTKKVRKVPPGLPSSLSL;NHAVGPSTAMPGGHGDMHG 3 8.7 0.97329 0.048206 0 0 0 0 5.63459 0 0 0 0 0 0 0 7.26538 0 0 A0A8C0MB97 A0A8C0MB97_CANLF UV-stimulated scaffold protein A UVSSA Canis lupus familiaris (Dog) (Canis familiaris) response to UV [GO:0009411] DAGRPLHEEDRTREQRQQQ;DEDNDDDDDDGDF;EDNDDDDDDG;SDGDSDSDSDGE 4 6.6 0.94181 0.05044 4.18539 0 0 0 0 0 0 0 0 0 0 0 4.2461 6.92291 3.98322 A0A8C0MBA0 A0A8C0MBA0_CANLF Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B PPP2R2B Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] NWGAHPGH;SEIISSISDVK 2 3.6 1.0041 -1.1044 0 0 7.72846 0 0 0 0 0 0 8.21611 0 0 0 0 0 A0A8C0MBA2 A0A8C0MBA2_CANLF Golgi apparatus protein 1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815] fibroblast growth factor binding [GO:0017134] ADSKTMLQCLKQ;IVGNLTELESEDIQIEALLMRACE;LMEDFSLSPEIILSCRGEIE;QQQQPPQP;WSNNLAVLE 5 6.1 1.0017 -0.91681 9.61394 0 0 0 8.84972 10.2022 0 0 0 0 0 0 0 10.6392 0 A0A8C0MBA6 A0A8C0MBA6_CANLF RNA binding motif protein 26 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DADPSALAKYVLALV;DEEEIIPLSFHEFEL;EITKEEER;HYFKMMMKKKRTMNLVLGEDDLT;SLWWMTHYFKMMMKKKRT;SRYRENRSRDERKKD;TESWSEFHED;TSPKVMQPLV;VSKPSVSATEKV 9 11 1.0029 -2.3538 6.72465 8.90225 0 9.10899 0 0 0 0 10.2073 0 0 0 12.7007 0 0 A0A8C0MBA7 A0A8C0MBA7_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EDGGEDEGEDEG;GGEDEGEDEGEGEGDG;IVLAGDAAVGKSS;LNSERDLEI;MDEDCDSLALCDPMQRM;SATLGVDFQ;SYMDEDCDSL 7 9.1 1.0035 -1.5955 0 0 0 0 0 8.15223 9.22028 0 0 0 0 0 0 0 4.96213 A0A8C0MBA9 A0A8C0MBA9_CANLF Ornithine decarboxylase (EC 4.1.1.17) Canis lupus familiaris (Dog) (Canis familiaris) polyamine biosynthetic process [GO:0006596] carboxy-lyase activity [GO:0016831] LGDILKKHLRWLKALPRVT 1 4.2 0.95045 0.049713 0 0 0 0 0 0 8.55697 0 0 0 0 0 0 0 0 A0A8C0MBB0 A0A8C0MBB0_CANLF Zinc finger protein 263 ZNF263 Canis lupus familiaris (Dog) (Canis familiaris) urogenital system development [GO:0001655] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EAVSDSTLFL;ESGEEAVTLVEDMQ;VTLVEDMQRELGR 3 4.7 0.99114 -0.19497 0 9.83365 0 0 9.27831 0 0 0 3.99594 0 0 0 0 0 0 A0A8C0MBC0 A0A8C0MBC0_CANLF SET binding factor 2 SBF2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] DGQSAQQWMDRIQSCISDA;DWMMLTPKQFPSEDSE;ENDFLTKVLNG;EVEVSGLIQPAEVFAP;GVHGYRDKCFTQ;LDSDYERL;LDVIIADLDG;NETRVQELIQ;VHQVHNQYPTEFE;WFPQLHRIMQ 10 6.6 1 -0.61146 0 0 0 0 0 0 0 0 0 9.0337 0 0 0 7.2317 0 A0A8C0MBC1 A0A8C0MBC1_CANLF Zinc transporter ZIP13 (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) SLC39A13 Canis lupus familiaris (Dog) (Canis familiaris) intracellular zinc ion homeostasis [GO:0006882] cytoplasmic vesicle membrane [GO:0030659] zinc ion transmembrane transporter activity [GO:0005385] AALSGGHSLAQPAAEPGV;NVFLHLLPEAWAYT 2 8.6 0.98374 -0.24439 8.9362 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MBD0 A0A8C0MBD0_CANLF Transcription factor 4 TCF4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] EPDSAPGG;ERLSYPSHSSADINSSLPPM;NHAVGPSTAMPGGHGDMHG 3 7.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 10.6239 0 0 0 0 0 A0A8C0MBD5 A0A8C0MBD5_CANLF POU domain protein POU5F1 LOC481709 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LSFKNMCKLRPL;SPGGGGDGPG 2 6.1 0.99448 -0.56102 7.94451 0 0 0 7.34056 0 0 0 0 0 0 0 0 0 0 A0A8C0MBD9 A0A8C0MBD9_CANLF procollagen-lysine 5-dioxygenase (EC 1.14.11.4) PLOD3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475] ENVPTVDIHMKQV;FSAVKLVGPEEALTPGEARDM;LAGSPAELL;MNFVVRYRPDEQPSLRPH;PTKLQLNYL;TVGGGQKV;YIHENYSRAL 7 11.9 1.0018 -1.8187 0 8.33172 10.2632 0 0 0 0 0 0 0 8.50863 8.88203 10.6836 0 10.8214 A0A8C0MBF5 A0A8C0MBF5_CANLF Zinc finger protein 510 ZNF510 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AVIFKLEQGEEP;FQKGHLIQ;QKSHLSTHRRIHT;RKAILSDHQRI 4 7.1 1.002 -0.95962 0 0 9.02874 0 0 0 0 10.309 0 9.12291 0 0 0 0 0 A0A8C0MBH9 A0A8C0MBH9_CANLF ADF-H domain-containing protein DBNL Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; endosome [GO:0005768]; plasma membrane [GO:0005886]; synapse [GO:0045202] actin binding [GO:0003779] AAPGGLGM 1 1.8 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 9.98114 0 0 0 A0A8C0MBI3 A0A8C0MBI3_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 2" AGAP2 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924] AAELAHVVI;EGSAGQAEEENFEF;GAPTPSKL;LAAELAHVVI;VGWGDRQSQ 5 3.6 1.0016 -0.99518 0 0 0 0 0 9.39223 0 11.6307 0 9.27768 0 10.882 12.6752 11.1838 0 A0A8C0MBI6 A0A8C0MBI6_CANLF Protein kinase domain-containing protein DCLK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DKSIVHRDLKPE;EVYLIMEYVQGGDLFDAITE;GEGGWQGEGP;HEVYETEGEVYLI;PIFTVCGTPTYVAPE;QEEQEEQEEQEEQEEQEEQEEQDR 6 15.8 0.73313 0.25601 0 8.97151 0 0 0 0 0 0 0 8.57735 8.83213 0 0 3.42559 0 A0A8C0MBK5 A0A8C0MBK5_CANLF Eukaryotic initiation factor 4A-III (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) EIF4A3 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] AVATMATS 1 2.1 0.98979 -0.26592 0 0 0 0 0 0 0 9.92512 0 0 0 0 0 0 0 A0A8C0MBL2 A0A8C0MBL2_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AASHSSSG;EGLRKRRRLLSIIVVLVVTFA;GEKSASYS;GLRKRRRLLSIIVVLVV;GVSSTAVGFVVP;LRKRRRLLSIIV;LRKRRRLLSIIVVLVVTF;PFTVMLTCYFFI;VPFTVMLT;YYGADNQSECEYADW 10 19.5 1.0027 -2.1727 0 0 14.4217 9.22345 7.43154 0 12.3071 0 0 0 0 4.64368 7.36115 0 7.28216 A0A8C0MBL4 A0A8C0MBL4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TDNTKRNNVDFSIRISNITPAD 1 10.7 0.93385 0.065591 7.35808 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MBL5 A0A8C0MBL5_CANLF FAM20 C-terminal domain-containing protein FAM20C Canis lupus familiaris (Dog) (Canis familiaris) enamel mineralization [GO:0070166] Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] PAAADPAE;PANNICFYGECSYYC 2 4.2 0.99032 -0.21204 0 0 0 10.0154 0 0 0 0 0 0 0 0 0 9.40467 0 A0A8C0MBP1 A0A8C0MBP1_CANLF Beta-arrestin-2 (Arrestin beta-2) Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor internalization [GO:0002031]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; signal transduction [GO:0007165] cytoplasm [GO:0005737] angiotensin receptor binding [GO:0031701] LDKVNPVDGAVLV 1 16.9 0.99093 -0.13514 0 0 0 0 0 11.393 0 0 0 0 0 0 0 0 0 A0A8C0MBQ0 A0A8C0MBQ0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DRHPPVPSLAESSSRRCNS 1 4.6 0.9502 0.049702 7.02813 0 0 0 0 0 0 0 0 0 0 0 0 9.52227 0 A0A8C0MBQ9 A0A8C0MBQ9_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; regulation of dopamine secretion [GO:0014059]; regulation of potassium ion transport [GO:0043266]" plasma membrane [GO:0005886]; synapse [GO:0045202] "dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]" PTNYFIVSLAAADLL;VGGGGAPG;VYSSVCSFFLPCPLMLLLYWA 3 6.4 1.0022 -1.2968 0 10.7876 0 0 0 0 0 0 0 0 0 0 5.18456 9.09236 0 A0A8C0MBR0 A0A8C0MBR0_CANLF Histone H3-like centromeric protein A (Centromere protein A) Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] AAEAFLVHLFEDAYL;CVKFTRGVDFSWQAQALL;LVHLFEDAYL 3 25.6 1.0025 -1.1505 0 0 0 0 0 8.11129 10.3952 0 0 0 0 0 0 0 0 A0A8C0MBV6 A0A8C0MBV6_CANLF Gamma-aminobutyric acid type A receptor subunit beta3 GABRB3 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; nervous system process [GO:0050877]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594] DTRNSARPFDNSG;SEVNMDYTLT 2 5.3 0.99066 -0.2102 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5414 0 A0A8C0MBY5 A0A8C0MBY5_CANLF RecQ-mediated genome instability protein 1 RMI1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; resolution of meiotic recombination intermediates [GO:0000712] nuclear body [GO:0016604]; RecQ family helicase-topoisomerase III complex [GO:0031422] nucleotide binding [GO:0000166] NQSIPGITDVLDPA;PDPIVSVIPNNPNQSIPGI;PLTLNRTPDESI;QAQMNKQVFEQWLLTDLRD;TDLRDLEHPLLPDG;TDNKIKQTFSSIDGH 6 12.5 0.98331 -0.25664 0 10.0004 0 0 7.87664 8.5297 9.79196 5.31056 0 0 0 0 6.69738 0 0 A0A8C0MC00 A0A8C0MC00_CANLF KIAA1549 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASGPPPAG;EASRRVPNKIQLIAM;EFPVVDDLSS;ETTSYSGLSPVAR;GVVIPVLVVMVIVIIL;IPSTAPLV;LLLLLLLL;LPGLWLRRRLLLLLL;LPGLWLRRRLLLLLLLLARPA;LSASSLVP;LVPEAIPSPLPTEPMFVGSSFTPTD;LVVMVIVIILYWKLCRTDKL;LWLRRRLLLLLLLLAR;LWLRRRLLLLLLLLARP;PCRGHHRFPDS;PGLLLPGLWLRRRLLLLL;QRAAIILG;RLLLLLLL;RLLLLLLLL;RRLLLLLLLLA;RRRLLLLLLLL;TRPCPSGGHLATPASPT;VEPSLVPEREPG 23 9.9 1.0031 -2.5003 0 9.1004 12.3195 9.77931 9.74067 8.36571 10.6166 11.5687 0 0 5.89973 14.0595 9.93185 10.4353 5.34579 A0A8C0MC06 A0A8C0MC06_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) EIEEDTKRWKYIPCSW 1 2.4 0.95685 0.049233 0 0 0 0 0 0 5.60443 0 0 0 0 0 0 0 0 A0A8C0MC22 A0A8C0MC22_CANLF Signal recognition particle 9 kDa protein SRP9 Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312] KIAPRQSRKKKKKKKVLARVV;KKKKKKKV;KKKKKKKVLARVV;KKKKKKKVLARVVLK;QSRKKKKKK;RFKIAPRQSRKKKKKKKVLARVV;RKKKKKKKVL;RKKKKKKKVLARVVL;RKKKKKKKVLARVVLK;SRKKKKKKK;SRKKKKKKKV 11 15.1 0.99913 -2.9231 6.75087 2.85004 3.91025 5.44072 0 0 0 9.89189 0 0 7.92493 6.31098 9.76838 0 0 A0A8C0MC37 A0A8C0MC37_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] ARVLPPPRAP;CACCSGCT;YSGKEKAF 3 3.6 1.0034 -1.6871 4.66482 0 0 0 0 0 9.53064 5.14282 9.35076 12.1837 5.9007 0 5.56178 9.95453 9.63706 A0A8C0MC43 A0A8C0MC43_CANLF Biliverdin reductase A BLVRA Canis lupus familiaris (Dog) (Canis familiaris) heme catabolic process [GO:0042167] biliverdin reductase (NAD(P)H) activity [GO:0004074]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270] EDQYMKMTVCLET;LEDALSSQEVE;TPLKEEIKMNAEP 3 9.2 0.99006 -0.50977 0 0 0 0 8.98954 0 0 0 0 0 3.85569 0 0 0 0 A0A8C0MC46 A0A8C0MC46_CANLF Olfactory receptor family 1 subfamily L member 6 OR1L6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;QLQKPLFAIFLI;SLRNKDMKRGLIKLR;VGCLIQMYFF 4 16.1 1.0039 -0.80836 0 4.28214 0 0 0 0 0 6.64875 6.42819 0 7.69077 0 0 0 0 A0A8C0MC48 A0A8C0MC48_CANLF Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) SGK1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine/threonine kinase activity [GO:0004674] CEAKEPCNHASILTKPD;DPEFTEEPVPNSI;EKESCSWETQSGC;KHPFLVGL;VLHKQPYDRTV 5 12.4 1.0018 -1.2538 0 11.7107 0 0 0 0 0 0 0 0 0 8.38965 0 0 0 A0A8C0MC55 A0A8C0MC55_CANLF Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) Canis lupus familiaris (Dog) (Canis familiaris) regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] early endosome [GO:0005769]; focal adhesion [GO:0005925]; late endosome [GO:0005770]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708] FLPYPLQRLWPRSQPASP;LVAPPPCLRP;NLVDLQKKLAEL;TRSGEASECACS 4 8.2 1.0026 -0.71481 0 0 0 0 0 0 10.4069 2.34659 10.1105 0 0 0 0 0 9.69754 A0A8C0MC67 A0A8C0MC67_CANLF Mitochondrial inner membrane protease ATP23 (EC 3.4.24.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AAGAPQQQQQQ;TYARYAHRDFQNRDR 2 10.7 0.93843 0.089379 0 7.97757 0 0 0 0 0 0 0 0 0 8.43271 0 0 0 A0A8C0MC84 A0A8C0MC84_CANLF UBZ1-type domain-containing protein TAX1BP1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] autophagosome [GO:0005776]; phagophore assembly site [GO:0000407] metal ion binding [GO:0046872] EQVQATRQE;LDGNKESMITHFKEEIGRLQ;MEGQNSQSPQKISQCLHTC;QEVPLQTSNFAHVI;VEELLTMEDEGN;VLQYGNPYATQETRDG 6 11.4 0.93571 0.099062 0 0 0 0 3.63308 0 8.03172 0 0 0 0 0 0 0 0 A0A8C0MC85 A0A8C0MC85_CANLF Inverted formin 2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] GDGDGDGD;IADALLQLTCI;PSNVAQEHSS 3 2.3 0.98989 -0.26167 8.21252 8.03221 0 9.83602 0 0 0 9.99138 0 0 0 0 0 0 0 A0A8C0MC89 A0A8C0MC89_CANLF CID domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124]; termination of RNA polymerase II transcription [GO:0006369] mRNA cleavage factor complex [GO:0005849] mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993] EKITKKELDQ;EQFEQYWDEEEEEW;GAVESCEICQEQFEQYWDE;GDEHSKSPHLRHRESW;LAVSLSVQQETSN;QGVGMRFEGPSVPGGGL;SVTRDGPTKMIF;TAKAPSSEKLPVMY;TKRWKSGWEENKSLQ 9 8.1 0.99214 -0.0067438 10.7499 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCA7 A0A8C0MCA7_CANLF Nidogen 2 NID2 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509] APPSNPCEDGSHTCA;ELFPYGQSRGDQLLQEG;FTGATFTH;GSTSPLDNIRPATIGGDLTKAH;IVSYADHFYHT;LGPGGESATL;PHCRPPEPTQRPQTVCERWRE;PPLLLLLL;PPLLLLLLL;REGPYFSLTSTEQSVKNLYQQSNL;RLALPPLPPPPLLLLLLL;TDVDECSENRCHPSATCYNT;TEVFTYNAANKETC;VDECSENRCHPSAT;YLYVGTNGIIST 15 14 1.003 -2.42 0 0 12.3089 8.83365 6.80452 6.62182 8.68194 9.59218 10.8266 0 0 8.82311 0 0 11.5779 A0A8C0MCA8 A0A8C0MCA8_CANLF Short transient receptor potential channel 1 TRPC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480] cation channel complex [GO:0034703]; plasma membrane [GO:0005886] "inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" DFLEESRNQL;SLVYNEDKKNTMGPALE 2 3.7 0.98881 -0.30747 0 0 9.65234 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCB8 A0A8C0MCB8_CANLF Uncharacterized protein C6H16orf89 Canis lupus familiaris (Dog) (Canis familiaris) LLLLLLLL;LNWRAEAI 2 4.7 0.98525 -0.25337 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.10234 A0A8C0MCC2 A0A8C0MCC2_CANLF Uteroglobin (Secretoglobin family 1A member 1) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] phospholipase A2 inhibitor activity [GO:0019834] KEMIAFLFQHEALYKPHLQLAYNPP 1 27.5 0.97695 0.035538 0 0 0 0 0 0 0 0 0 4.58123 0 0 0 0 0 A0A8C0MCC4 A0A8C0MCC4_CANLF Olfactory receptor OR5M3C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FIAFVHVE;TLWTHGLYFCGNV;VGNIGMIILIRISP 3 11.3 1.0016 -0.74821 0 0 0 0 0 9.17453 0 0 0 0 0 0 0 0 0 A0A8C0MCE2 A0A8C0MCE2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KQVSHGDGHSPG 1 13.2 0.99616 -0.086024 9.48585 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCE6 A0A8C0MCE6_CANLF Myozenin 3 Canis lupus familiaris (Dog) (Canis familiaris) Z disc [GO:0030018] VGETLPRA;VPFGGPLVGE 2 6.2 0.98808 -0.49237 0 9.56115 0 0 0 0 0 0 0 0 7.43104 0 0 0 0 A0A8C0MCE8 A0A8C0MCE8_CANLF Autophagy related 7 ATG7 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-like modifier activating enzyme activity [GO:0008641] ALDVGFWHELTQRKL;DDRMNEPPTSLGLV;IAASKRKL;LAGGKPKA;VGFWHELTQRKLNEYRLDEAPKD 5 9 1.0036 -2.0474 0 0 0 0 0 8.15497 0 7.9633 0 0 0 0 8.62417 0 0 A0A8C0MCF7 A0A8C0MCF7_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] small molecule binding [GO:0036094] EGAQKMQQLAPQVGL;LLPQSGECRP 2 13 0.98953 -0.5258 0 0 0 8.40595 0 0 9.37801 0 0 0 0 7.75842 0 0 0 A0A8C0MCG6 A0A8C0MCG6_CANLF Fibroblast growth factor receptor (EC 2.7.10.1) FGFR3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007] APSSGDDEDGEDEAEDTAGAPYWT;DLYMIMRECWHA;PSSGDDEDGEDE;YSCRQRLTQR 4 5.7 0.97413 0.041303 0 7.36955 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCG9 A0A8C0MCG9_CANLF Epoxide hydrolase (EC 3.3.2.9) EPHX1 Canis lupus familiaris (Dog) (Canis familiaris) catabolic process [GO:0009056]; lipid metabolic process [GO:0006629]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789] cis-stilbene-oxide hydrolase activity [GO:0033961] KLISYSYMARGGHFAAFEEPELLAQ;MRESGYMHIQ;PRRHEEGRG 3 9.6 1.0022 -1.1523 0 0 0 0 0 0 9.18802 0 11.0906 3.78858 0 0 0 0 7.69132 A0A8C0MCH2 A0A8C0MCH2_CANLF OCIA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LVSYLRECQDKFHSLEDLLF 1 22.2 0.98528 -0.23555 0 0 8.74873 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCH9 A0A8C0MCH9_CANLF Centrosomal protein 78 CEP78 Canis lupus familiaris (Dog) (Canis familiaris) CLSASSAL;GVPVSEQRQ;KPESKQNPLGQ;KPESKQNPLGQMQNI;LNCNTLIGDL 5 5.3 1.003 -1.5874 0 10.26 0 0 0 8.79399 0 0 0 0 0 0 10.7465 9.68457 0 A0A8C0MCI6 A0A8C0MCI6_CANLF Proline rich 11 Canis lupus familiaris (Dog) (Canis familiaris) RRRKLKAKAKRLFKKK 1 4.4 0.95635 0.049233 5.17568 0 0 0 0 0 0 0 0 0 0 0 0 0 9.76173 A0A8C0MCJ5 A0A8C0MCJ5_CANLF POU domain protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HSPFQRQH;KAFKIRRLSL;PQPPPPQPPQPQPQ;PQPQPQPQPQNHNHNHSRASPPQQ 4 7.5 1.0029 -1.5895 0 0 0 0 0 6.51748 7.13668 8.98499 0 6.7339 5.99806 0 0 0 0 A0A8C0MCK8 A0A8C0MCK8_CANLF Coiled-coil domain containing 180 Canis lupus familiaris (Dog) (Canis familiaris) CHRLEKEA;DILVSSEALEEEAKLDLVTPESFA;EAEKKEEEEEEE;ESPKQKTSILIRRKLARL;NQQCDKDRQYCHLVH;VIIPPRLVLQIK;VIIPPRLVLQIKRQL;VRQQKWAHSLP;WHSALSILNKNLDNYHMDCMMRIRL 9 7.9 0.98943 -0.26403 0 0 10.7311 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCM0 A0A8C0MCM0_CANLF Nuclear receptor corepressor 1 NCOR1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654] DNA binding [GO:0003677] AENSSDTESAPSPSPV;DMAAAQPGTEIFNL;EDIEASNEEENPEDSEGF;EEEMEVAKKGLV;GVPARRMMKNQ;KKLILFFKRRNHARKQR;LEEQRQRQEQIDLE;LPAGGPSISQGLPAS;MMKNQVMRKKLILFFKRRNHARKQR;MRKKLILFFKRRNHA;PCSTAKSPSREWEVLQ;PPNQGAFSTEQSRYPPHSVQYT;QSTRPIIEGSISQGTPIKFDSNSG;RKKLILFFKRR;SDNDSSATCSADEDVDGEPE;SPMMNRTADV;VCKPKLISKSNSRKSK;VISPASSPVPPPEKLQAYP 18 9.9 1.0023 -1.2224 9.90266 0 0 7.71287 7.66995 9.48551 14.7918 7.54605 0 7.37816 0 0 10.6544 0 10.4558 A0A8C0MCM8 A0A8C0MCM8_CANLF Receptor tyrosine kinase like orphan receptor 1 ROR1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; Wnt-protein binding [GO:0017147] LLLLLLLL;LLLLLLLLAARGAAA;PSLCHYAFPYCDETS 3 3.2 0.92976 0.10776 0 0 0 0 0 0 6.69572 0 4.142 0 0 0 0 8.25465 0 A0A8C0MCQ0 A0A8C0MCQ0_CANLF Patatin like phospholipase domain containing 7 PNPLA7 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] endoplasmic reticulum membrane [GO:0005789] lysophospholipase activity [GO:0004622] AGKAKRQA;CTGRRGAGRAVEAVTGARASGA;DLWIPYFTITTDI;EDLWIPYFT;ELAKLPAGALTSIKRR;EVGYQHGRTVFDIW;LCKHMVFVQLLEGEHVF;LEGEHVFQPGE;LLWKRWNPLATKVKV;LSLAKRILRFKKE;PSAVFHYSEANSEE;SLWRYVRASMSLSGYMPPLC;TVGELERMLESTA;VGITVFFVY;YRTLDFGKF 15 13.1 0.99703 -3.6615 11.986 10.3615 3.26595 5.26896 0 11.227 10.5603 5.60297 0 0 3.80808 8.05056 0 9.98228 0 A0A8C0MCQ1 A0A8C0MCQ1_CANLF DNA helicase (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; metal ion binding [GO:0046872] DDDDEEEEGGCEEEEDDHMEFCR;DEEEEGGCEE;EEDDHMEFCRVCKDGG;IVRVELSQMQKKYYK;NDMDEPPPFDYG;PRAYHLVCLDPELEKAP;SIHSSSWGPGP;TVTIAPPL 8 6.9 0.98495 0.035491 0 9.26489 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MCQ3 A0A8C0MCQ3_CANLF Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] CPTCSTSLLNGDFKVTYDVNRDQLC;IDVDIFEPQ;MTCLVDEEKMKNLLR;PGSGGPVF;TFRLTYEEVLKR 5 7.6 1.0025 -0.71768 0 11.7515 12.1416 10.7148 0 0 0 0 0 0 11.6119 4.43516 12.0529 12.1195 0 A0A8C0MCR2 A0A8C0MCR2_CANLF Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) Canis lupus familiaris (Dog) (Canis familiaris) mast cell degranulation [GO:0043303]; prostaglandin biosynthetic process [GO:0001516] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791] isomerase activity [GO:0016853]; small molecule binding [GO:0036094] APRQSSSLHLAS;PSHGGHGLHLAHSL;VASPSRTRPHP 3 9.6 0.99213 -0.54187 0 0 0 0 0 0 0 0 0 0 0 10.3499 0 0 0 A0A8C0MCS9 A0A8C0MCS9_CANLF Tonsoku-like protein (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA repair [GO:0006281] chromosome [GO:0005694]; nucleus [GO:0005634] AVSHYEQELRLRGGD;PLHEACNYGHLGEYGGR;PLLRALKLHTALRELRLAG;PLSPCPGSPE;RPGSSSSR;TPLLRALKLH 6 5.4 0.98981 -0.22289 0 0 0 0 0 0 0 0 0 0 0 0 0 7.96538 0 A0A8C0MCU6 A0A8C0MCU6_CANLF PAXX non-homologous end joining factor PAXX Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via nonhomologous end joining [GO:0006303] LLLPPVPRV;PEQDSNSRIGILTLECT 2 9.6 1.0036 -1.064 0 0 0 0 0 0 0 0 0 0 0 0 0 4.26978 0 A0A8C0MCV7 A0A8C0MCV7_CANLF DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nuclear lumen [GO:0031981] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; ribonucleoside binding [GO:0032549] LPAARVERA;MTIGMLIE;PYMYDYYDMDNYP 3 2.6 1.0026 -1.374 9.23905 0 0 0 0 0 0 0 0 0 0 0 0 0 4.44327 A0A8C0MCY0 A0A8C0MCY0_CANLF Mitochondrial ribosomal protein S27 Canis lupus familiaris (Dog) (Canis familiaris) DRQKKDHKTL;HVLYHCLAKKTDCSWE;LPPSLAGTLRRKK;MATYEQKLQQWHLERVHLIQR;QGSGDLLEQLDIEETEQ 5 12.9 0.98734 -0.37854 0 0 0 0 0 3.9834 0 8.72622 10.216 0 0 0 0 0 0 A0A8C0MD04 A0A8C0MD04_CANLF Piezo-type mechanosensitive ion channel component Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] CTVWTCVIIVCKMLY;DMSSSSADSG;EEEEEEEEEEEEEEEEEEEETSDLR;EEKQERRKEEEMEEDDDQD;EKEDITVAELE;KDSEEEEEEEEEEEEEEE;LLIPLFSEP;LSFVYLIYLLLIPL;RDDSAGQSHMAVSPDDS;SEKRYPQP;SQENEEKDDEQDIQMEGDA;VDQGGEATGNV;VEAEQDDEAVAAD;VKCVYFGLSAY;VMYKIIYMVLFLFCVALYQVHYEWW;YFPDFIVRPN 16 7.7 1.0008 -2.7329 7.4582 15.6553 0 0 8.85755 8.59995 9.02677 8.13381 0 0 0 11.5993 11.2578 11.3986 8.05039 A0A8C0MD05 A0A8C0MD05_CANLF Brain enriched guanylate kinase associated Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAPGGATV;AFPAGFRHEAFPGYAASL;GWWGECAEQSWNV;NSTDSAAEDEEEAEAE 4 5.8 1.0029 -1.3394 0 11.097 2.54552 0 0 0 11.643 11.0167 11.504 10.7 0 3.82619 3.06752 0 0 A0A8C0MD09 A0A8C0MD09_CANLF RAS protein activator like 2 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] ISNPDTISNTPGFD;NSMDTVNTSPFKVPG;RYSMQILPQVS;VGSNASSS 4 3.4 1.004 -1.1044 0 7.29453 0 0 0 0 0 0 7.76487 0 0 0 0 0 0 A0A8C0MD25 A0A8C0MD25_CANLF FYVE-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SEKEQRQALQ;SPAPVCPEPGPQF 2 4.2 0.94686 0.061408 0 0 0 0 0 0 0 0 8.59835 0 0 0 0 0 0 A0A8C0MD30 A0A8C0MD30_CANLF 5'-3' exoribonuclease 1 (EC 3.1.13.-) Canis lupus familiaris (Dog) (Canis familiaris) nuclear-transcribed mRNA catabolic process [GO:0000956] cytoplasm [GO:0005737] 5'-3' RNA exonuclease activity [GO:0004534]; RNA binding [GO:0003723] AGVAAEEAKNYKE;CLMCWYDRDTEF;EHFSEVFVDLKW;EYYPPDFKTDLNG;FLVGNDFIPHLP;FSEVFVDLKW;LVNAESDELNVE;QWILHYYYHGVQSWSWYYPYHYAPF;SNLALGAANIMPSSSHLFG;TEFMARLHEHLKYFV;VIPDRDAEFRLFD 11 8.6 0.99246 -0.14021 10.3711 0 10.0474 8.59111 9.1458 9.80344 9.11912 0 6.88191 7.68166 0 0 0 9.83692 8.65044 A0A8C0MD49 A0A8C0MD49_CANLF Suprabasin Canis lupus familiaris (Dog) (Canis familiaris) GQAGKEGDKIIQGVHH;GVNQAGSEAEKFGHGVHH;LPQNVHNGVNQAG 3 9.7 0.84984 0.15728 8.79828 0 0 0 0 0 0 0 0 0 0 0 9.51787 0 8.49345 A0A8C0MD72 A0A8C0MD72_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EISENYTSDFSQ;HQQPDWDTRTKSKEFLQKKEVSED 2 5.3 0.93333 0.091743 0 0 7.92867 0 0 0 0 9.19126 0 0 0 0 0 0 0 A0A8C0MD91 A0A8C0MD91_CANLF dual-specificity kinase (EC 2.7.12.1) CLK4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] GLSTYDFI;LCHDEEHEKLFDL;LSTYDFIKENSFLPFQ;LSTYDFIKENSFLPFQIDHI;RARYEIVD;TLDEALQHPF 6 13.9 1.0032 -2.0951 0 11.4605 9.21454 8.91052 0 7.63938 0 12.1369 9.89881 10.6021 0 10.4186 0 0 0 A0A8C0MDB2 A0A8C0MDB2_CANLF "Signal peptide, CUB domain and EGF like domain containing 1" Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] CERRWYLKVSRIRPH;DECQDNNG;DNNGGCQQICVNAMGSYE;LYGTTHCGDVDECSMNNGSCD;VGTYQPEPGRTGCFSCGGGLLTK;WNQKDCVEMGKCLSRAKASPWAQL 6 9.4 0.95197 0.053886 0 0 0 0 0 0 0 8.64645 0 0 0 0 0 0 0 A0A8C0MDB7 A0A8C0MDB7_CANLF Tankyrase 1-binding protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AALPILEP;DESSPHHSQLPEVQSPT;EIGKEEAGKEEMPPL;SGGLFSPS;SPGLEAREQGPGETSGPE;TPEERSAPLDL;VALLQAEERYEE;VGEVSQCPDLGLRDSSALSP;VGHRGWGGD;VGQGAQGP 10 7.2 1.0029 -2.5049 0 8.02686 0 0 9.81911 12.6679 0 10.9949 0 0 0 0 5.74292 0 9.67225 A0A8C0MDC1 A0A8C0MDC1_CANLF Uncharacterized LOC474694 SLBP2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729] TDETVLQRRQK;WDELISALITLIIL 2 12 0.93076 0.09639 0 0 0 0 0 0 0 0 0 0 7.5763 6.3875 0 0 4.93876 A0A8C0MDD3 A0A8C0MDD3_CANLF AAA+ ATPase domain-containing protein DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] CLDTMTLNYDL;DEFNRIEVEVL;DMIAPEEE;DTYYIPPHGSYQS;EEKLVRVQEILD;ETARMMVKIEEE;FQEWIDNGPPVVFWISGFY;GAISFLNVVWLSCY;GYNKELEGFRKREVMTT;ITKNYSSYDWRE;LTAYEFSIKSEEW;MLQQEMEIE;MTLNYDLCERAQNLKDR;NESDLRISMQQV;QEMEIEGKETQPSESDL;SEDNICDLNDFQW;TVSRCGMI;VRHGYMIVGDP;VTPTSYLELILTFKTL 19 5.7 1.0034 -2.0941 9.67739 0 0 9.25144 14.8727 3.71995 9.63885 0 9.36332 7.48478 13.5135 8.88515 12.2061 0 9.67363 A0A8C0MDE5 A0A8C0MDE5_CANLF Mucin like 3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TTQENTAEGP 1 2 0.99993 -0.61146 0 0 0 0 0 0 0 0 0 0 0 8.85994 0 0 0 A0A8C0MDI1 A0A8C0MDI1_CANLF THAP domain-containing protein 5 THAP5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DEKEVCLKAKS;LDIEDSLYKDVDYETEVLQ;LDIRWGIR 3 10.8 0.99282 -0.18797 0 0 7.44336 7.59589 8.01369 0 0 0 0 7.73342 8.41257 0 11.1253 0 8.00478 A0A8C0MDK5 A0A8C0MDK5_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KB1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to insulin stimulus [GO:0032869]; signal transduction [GO:0007165] mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GVGPYELGMEHCEKFE 1 3.5 0.99214 -0.036677 0 0 0 0 0 0 0 9.41043 0 0 0 0 0 0 0 A0A8C0MDM0 A0A8C0MDM0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SFSFIHGL;VIEDTWHYFL 2 11.7 0.98731 -0.26018 0 0 0 0 0 0 0 10.8123 0 0 0 0 0 0 0 A0A8C0MDN5 A0A8C0MDN5_CANLF Neurotrophic receptor tyrosine kinase 3 NTRK3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] ATP binding [GO:0005524]; neurotrophin receptor activity [GO:0005030]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] LYTGLQKLTI;REIMLNPISL 2 3.3 0.33094 0.62245 0 0 10.9959 0 0 0 0 0 0 10.4618 4.61477 10.6454 0 11.3037 0 A0A8C0MDN6 A0A8C0MDN6_CANLF T-cell surface antigen CD2 CD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEELGPRAHR;LTCEITSGTDPTLM;VLFAPGWQEELRITT 3 10 1.0022 -0.6814 0 9.58933 0 0 8.83656 0 15.3169 0 0 0 0 0 0 0 0 A0A8C0MDN8 A0A8C0MDN8_CANLF RAB GTPase activating protein 1 RABGAP1 Canis lupus familiaris (Dog) (Canis familiaris) DYGLRELFKQNFEDL;KKIVIYVQQ;KWHLNLSVRPKQLS;QGDETPSTNNGSDDEKT;TATGWLPPDI 5 6 1.0021 -1.2546 0 7.64032 0 0 0 0 0 11.7475 0 6.65921 8.19298 0 10.78 0 0 A0A8C0MDP2 A0A8C0MDP2_CANLF Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (Protein Idas) Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA replication [GO:0006275] nucleus [GO:0005634] GGGGGGGG;PGGGGGGG;QLHVTLTQKQEEI;QPEPASRE;SPPLRPPDMPPPE 5 11.4 1.0023 -0.65168 0 10.158 0 0 0 0 0 0 0 0 0 0 0 12.1967 0 A0A8C0MDP5 A0A8C0MDP5_CANLF CUGBP Elav-like family member 4 (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) CELF4 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] ERQVDGNRCEEGEGV;GVQQYAGRPEGCNLFIYHLPQEFG;LTYCERESALKAQSALH 3 11.6 0.9887 -0.20402 7.19328 0 0 6.73295 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MDR8 A0A8C0MDR8_CANLF Gasdermin E Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] membrane [GO:0016020] AIPGELKPP;DAGQGTSALDWP;KYQFLSVTLGDVL;QGTSALDWPLDVL;TTQQCVISEHVQI 5 7.6 0.98754 -0.50178 0 4.19959 0 9.72746 9.73011 0 0 0 0 0 0 3.58087 0 2.75375 0 A0A8C0MDT7 A0A8C0MDT7_CANLF "Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)" TSFM Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] translation elongation factor activity [GO:0003746] AASLRAAPPGLPAAP 1 3.6 0.99691 -0.098941 0 0 0 0 0 0 0 0 0 0 0 0 0 8.82442 0 A0A8C0MDU2 A0A8C0MDU2_CANLF Signal recognition particle 54 kDa protein (EC 3.6.5.-) SRP54 Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" "cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; ATP hydrolysis activity [GO:0016887]; endoplasmic reticulum signal peptide binding [GO:0030942]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] IPFYGSYTEMDPVI;KGGGALSAVAA;VFKELVKL 3 7.3 1.0014 -1.3153 0 0 0 0 9.16211 0 5.29131 0 0 0 0 0 3.8126 0 0 A0A8C0MDX0 A0A8C0MDX0_CANLF Mitochondrial ribosomal protein S36 Canis lupus familiaris (Dog) (Canis familiaris) 2-oxoglutarate metabolic process [GO:0006103] mitochondrion [GO:0005739] oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591] CLKVNKLLKKKKKKKK;CLKVNKLLKKKKKKKKKLF;KKKKKKKK;KKKKKKKKKL;KKKKKKKLF;KLLKKKKKKKKKLF;KLLKKKKKKKKKLFGEGT;KVNKLLKKKKKKKKK;LCLKVNKLLKKKKKKKKKLF;LKKKKKKKKKLFG;LKKKKKKKKKLFGEG;LKVNKLLKKKKKKKKKL;LLKKKKKKKK;LLKKKKKKKKK;LLKKKKKKKKKL;SLCLKVNKLLKKKKKKKKKL;VNKLLKKKKKKKK;VNKLLKKKKKKKKK;VNKLLKKKKKKKKKLFG 19 12.1 1.0033 -1.3352 4.81859 0 6.90376 7.85649 6.64003 6.47411 7.4441 0 7.10559 0 6.7761 7.94924 0 0 7.38974 A0A8C0MDX3 A0A8C0MDX3_CANLF Nucleosome assembly protein 1 like 1 NAP1L1 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDYDEEGEEA;DDDDYDEEGEEADEVMFT;DEEGEEADEVMF;GEAIEDDDDDYDE;VLYFTGEAIEDDD 5 8 0.99188 -0.27203 0 6.00034 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MDX5 A0A8C0MDX5_CANLF Potassium calcium-activated channel subfamily M regulatory beta subunit 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium-activated potassium channel activity [GO:0015269] CRGTALYPCVQVYVNNSESH;GGGGGGGG;YIPPCKRENQKNLENVMNWQQYWK 3 9.7 0.94005 0.1014 0 4.93301 0 0 0 0 0 0 0 0 0 0 0 9.12464 0 A0A8C0MDY2 A0A8C0MDY2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DCFEVDQLLYFEE;DLGDHEIPEDPLV;EEDEERRLGRKK;FDSCSEESEEEEEEIMF;IPSLDLDPLES;RKKRRLSI;SEVQKMTPRE;YANESIAIST;YDYLKRARRQ 9 18.6 1.0025 -2.1761 7.59515 9.65044 8.94058 0 0 8.47861 0 0 0 0 5.18951 0 0 0 9.83509 A0A8C0ME07 A0A8C0ME07_CANLF Cytokine-like nuclear factor N-PAC (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Putative oxidoreductase GLYR1) GLYR1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694] NAD binding [GO:0051287]; NADP binding [GO:0050661] EDCSSCFQ;KDADPHFHHFL;VTVWNRTAE 3 5.9 1.003 -1.5395 0 0 0 0 0 0 0 4.14926 0 0 0 0 0 0 0 A0A8C0ME09 A0A8C0ME09_CANLF Ubinuclein middle domain-containing protein UBN2 Canis lupus familiaris (Dog) (Canis familiaris) FEMKYYDEL;LACSSPLIKNSDK;TAHSSSLIAGHTGPVP 3 2.9 0.98608 -0.45362 0 0 0 0 0 0 0 0 0 8.1024 0 0 0 0 0 A0A8C0ME12 A0A8C0ME12_CANLF DUF4795 domain-containing protein C6H16orf96 Canis lupus familiaris (Dog) (Canis familiaris) CKNGVLYARHCIRHWRGGE;LGAGSSRGAFSFSED;LSHDMPVPWDRA;PDTAICKN;QVKCISCDRQVELMT;SLSRGSAWPFGGLGSLQ;TPWTALQRLKTTAGM 7 8.7 1.002 -1.7982 7.38007 0 0 0 0 12.1471 4.79145 10.346 0 0 12.7934 0 0 0 0 A0A8C0ME18 A0A8C0ME18_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] filamentous actin [GO:0031941]; microtubule organizing center [GO:0005815] PRAQNRKAIV 1 2.1 0.99563 -0.084895 0 0 0 0 16.8413 0 0 0 0 0 0 0 0 0 0 A0A8C0ME26 A0A8C0ME26_CANLF Amyloid beta precursor protein binding family A member 2 APBA2 Canis lupus familiaris (Dog) (Canis familiaris) EDYDEGLPEEEEGITYY;HYCPSEEGYQDYYPTEAN;LSNSVGEESLSL;VLMARRRMPRS;YPTEANGNAGGASP 5 8.8 0.98756 -0.37312 0 0 0 0 0 0 0 9.31529 0 0 9.69397 14.8097 0 9.4949 11.9984 A0A8C0ME29 A0A8C0ME29_CANLF Coiled-coil domain containing 152 Canis lupus familiaris (Dog) (Canis familiaris) VESNEEKHKE 1 5.1 0.99811 -0.61146 0 0 0 0 0 0 0 0 0 0 0 7.24783 0 0 0 A0A8C0ME30 A0A8C0ME30_CANLF Putative glycerol kinase 5 (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) GK5 Canis lupus familiaris (Dog) (Canis familiaris) glycerol catabolic process [GO:0019563] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" AAGPTPAG;DVGSSVIRCHV;INTGNNLQHTIRGFYP;IVAMVADQQSAMFGECC;STNKYHLVRAIL;VELVKSWNNSLIMKVQ;WNKKTGNHFHNFISWQDLRA 7 20.4 1.0019 -1.4262 9.25809 0 0 4.42445 0 8.65381 0 9.46467 11.5252 2.42056 8.5585 3.12481 3.57277 0 0 A0A8C0ME38 A0A8C0ME38_CANLF Janus kinase and microtubule interacting protein 2 JAKMIP2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] kinase binding [GO:0019900]; microtubule binding [GO:0008017] EALIVALQAANEDL;EATLYNALQQET;EREKTQEAKRIRELEQRKHTVL;LELEERERRSPPFNLQ;RDREKLIRRRKHRRSSKPIKRPVLD 5 10.9 0.98648 -0.33096 0 8.99107 0 0 0 9.21917 0 0 0 0 6.37053 0 0 0 0 A0A8C0ME47 A0A8C0ME47_CANLF 60S ribosomal protein L7a Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723] SYIRLQRQRAILYKR 1 4.8 0.95406 0.053874 0 0 0 0 0 0 0 0 0 0 0 6.13736 0 5.7567 0 A0A8C0ME73 A0A8C0ME73_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEVGMSSHN;LVCFCCSSDEVGMSSHNMS;LVLKLAFFILLVVQLARRA 3 10.7 1.0011 -0.70539 0 3.96874 0 0 0 7.90959 0 0 0 0 6.90773 0 0 0 0 A0A8C0ME86 A0A8C0ME86_CANLF Mitotic arrest deficient 1 like 1 MAD1L1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly checkpoint signaling [GO:0007094] nucleus [GO:0005634] EDKKMLEMQLERFTLQ 1 2.4 0.96121 0.049233 0 0 0 0 0 0 0 0 8.00596 0 0 0 0 0 0 A0A8C0ME91 A0A8C0ME91_CANLF Transmembrane protein 178B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PTPPPPGSFPRPP 1 5.7 0.94519 0.059664 0 0 0 0 0 0 9.0527 0 0 0 0 0 0 0 8.57493 A0A8C0MEA2 A0A8C0MEA2_CANLF Protein disulfide-isomerase A6 (EC 5.3.4.1) PDIA6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] protein disulfide isomerase activity [GO:0003756] LDLFSENAPPP;TSVTWSWTIWKEM 2 5.4 0.98566 -0.23591 0 0 0 0 0 0 0 0 0 0 0 0 0 8.68075 0 A0A8C0MEA3 A0A8C0MEA3_CANLF Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K21 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709] IPPHVLVNWAVQ;QLTSDESNKTWGRNTVCRQEEFE;QQLAEREIDVLER;VLLWELLTGEV 4 5.7 0.99418 -0.12157 0 0 0 10.0298 4.18301 0 9.95926 0 0 0 0 0 0 0 0 A0A8C0MEA4 A0A8C0MEA4_CANLF ADAM metallopeptidase domain 21 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] CQGESSTCPDDFYMQDGTPC;GVRLAQGR;LPEYCQGESSTCPDDF;LYYDNRYCVCQ;NICDLPEYCQGESSTCPDD;SLGLYYDNRYCVCQRR;TTGSICNTGTCCTNC 7 9.1 0.98916 0.019723 0 2.69644 6.8835 0 9.41553 6.779 0 0 0 7.42097 2.59046 0 0 0 9.12063 A0A8C0MEC3 A0A8C0MEC3_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCG1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; phospholipid catabolic process [GO:0009395] phosphatidylinositol phospholipase C activity [GO:0004435] ACQIAIRPEGKNNRLFVFS;AEGKIKHCRVQQE;CRVSLPEFQQFLLEY;EPYAICIEVL;IETGAPDGSFLVRESE;KILIKHKKL;KRKILIKHKKL;LKRKILIKHKKL;LPSPNQLKRKILI;RAQAEHMLMRVP;SEETSSDQGNEDEEEPK;SNYVEEMVSPA;VGGSPCPAASWAE 13 10.9 1.0033 -1.5691 0 7.13576 0 10.9009 5.57407 0 8.14512 0 0 6.59823 0 0 9.71618 0 4.56645 A0A8C0MEC4 A0A8C0MEC4_CANLF RUN domain-containing protein 3B Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGGGGGGGK;IEDSDLAHKLEKEQLEYIIVELQ;ISSDEEELRTLGS;SQNCICSI;SRGGGGGGG 6 14.3 0.99278 -0.151 11.3382 0 0 0 0 0 0 0 0 0 0 8.09787 0 0 5.49816 A0A8C0MEF4 A0A8C0MEF4_CANLF Rab9 effector protein with kelch motifs Canis lupus familiaris (Dog) (Canis familiaris) DIRDMKWQELSPTGAP;NRSFSDVYTMDLETRTW;PVRCMSEKEDSN 3 14 0.85933 0.1459 8.92333 0 0 0 0 0 0 0 0 4.23726 0 0 0 0 5.08142 A0A8C0MEI8 A0A8C0MEI8_CANLF YKT6 v-SNARE homolog YKT6 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139] AELDETKIILHNTMESLL;SPHSCCLLRRPP 2 10.2 0.93533 0.098753 0 0 0 6.03938 4.4871 3.93301 0 9.21638 0 0 0 0 0 0 0 A0A8C0MEK0 A0A8C0MEK0_CANLF Mitoguardin 2 (Protein FAM73B) MIGA2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741] SFFDIVLDFIL;TELFESLQVGDDPIL;VVCMSFFDIVLDFILMDAFEDLENP 3 6.7 0.99194 -0.20827 0 0 0 0 0 0 0 2.78496 0 0 0 0 0 6.92446 0 A0A8C0MEL3 A0A8C0MEL3_CANLF Epididymal-specific lipocalin-6 Canis lupus familiaris (Dog) (Canis familiaris) small molecule binding [GO:0036094] NNLKLLSSHRLERC 1 8.6 0.93644 0.060945 0 6.01476 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MEL7 A0A8C0MEL7_CANLF Presenilin (EC 3.4.23.-) PSEN2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; intracellular signal transduction [GO:0035556]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" EMEEDSYDSFGEPSY;GAALKLGQML;GALQLPYDPEMEEDSYDSFGEPSY;GVPPSCSVLQEPG;HVIMLFVPVTLCMIVVV;PPDFSAATSPDRGDHTGS;VLYKYRCYKFIHGW;VLYKYRCYKFIHGWL 8 12.5 1.0027 -1.141 9.60153 9.71168 0 5.74994 9.16518 0 0 0 0 0 0 3.90968 0 0 0 A0A8C0MEN1 A0A8C0MEN1_CANLF A-kinase anchoring protein 7 AKAP7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FDFFSLVTDAPHIN;LYSACFLCLFVWFFFGLNYLCLNT;SACFLCLFVWFFF;VLQRYTENRPSWPSGA 4 13.9 0.98761 -0.36705 0 6.47187 8.84552 10.7159 8.27547 0 0 0 0 0 0 0 10.7176 0 0 A0A8C0MEN8 A0A8C0MEN8_CANLF Bardet-Biedl syndrome 2 protein homolog BBS2 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737] IVAEMTETESKN;SNLIRSLLVRAE 2 3.5 0.99448 -0.5612 0 0 0 0 0 0 0 0 8.649 0 0 0 0 0 0 A0A8C0MES7 A0A8C0MES7_CANLF Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) EIF3B EIF3S9 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; viral translational termination-reinitiation [GO:0075525] "cytoplasmic stress granule [GO:0010494]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; synapse [GO:0045202]" RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] EDFRKYRKMAQEL;GDAAAEALSEGAGGED;LDAVKNADGYKLDK;LVTFSPLMGTQD;QEADGIDSVIVVDNV;RMREKQVPVD 6 9.8 0.98594 -0.42166 0 0 0 3.58916 9.90271 10.1396 0 0 0 0 3.76246 0 11.1436 0 0 A0A8C0MET0 A0A8C0MET0_CANLF Potassium voltage-gated channel modifier subfamily F member 1 KCNF1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] DIEIVVNVGGVRQ;GVDSAEGRWRRCQKCVWKFL;RIFKLARHSSGL 3 9 0.98598 -0.45211 0 0 0 0 0 0 8.27947 0 0 0 0 0 0 0 0 A0A8C0MET4 A0A8C0MET4_CANLF Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ILKPVKKKKIKREIKILE;ILKPVKKKKIKREIKILENLRG;KILKPVKKKKIK;KILKPVKKKKIKREIKILE;KVVVKILKPVKKKK;KVVVKILKPVKKKKI;KVVVKILKPVKKKKIK;KVVVKILKPVKKKKIKR;LKPVKKKKIKREIKILENL;LLSTENFFHSD;NEKVVVKILKPVKKKKIK;PVKKKKIKREIKILEN;QSRLTAREAMEHPYFYTVVKDQARM;TDFKQLYQTLTDYDIRFYMYEILK;VKILKPVKKKKI;VKKKKIKREIKILENL;VVKILKPVKKKKIK;VVKILKPVKKKKIKREIKI;VVKILKPVKKKKIKREIKIL;VVVKILKPVKKK;VVVKILKPVKKKK;VVVKILKPVKKKKI;VVVKILKPVKKKKIKR;VVVKILKPVKKKKIKREI 24 19.1 0.75278 0.23767 6.92422 11.8735 7.62315 4.47651 4.6792 5.5909 10.5228 6.47241 9.27712 7.50438 6.87897 8.70453 6.93499 7.51223 9.02597 A0A8C0MEU4 A0A8C0MEU4_CANLF Alpha-mannosidase (EC 3.2.1.-) Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] QYNYCSPRCAPGF;SLLVDNVKERATWFRTPH;VRDRTPAHSGGTGRSRD;VYTTVVEQLMLQKQRRFI 4 6.2 0.94416 0.059646 0 0 0 6.70722 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MEV0 A0A8C0MEV0_CANLF CTCK domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] APALPLPLPHPLPCP 1 2.8 0.94979 0.053892 0 0 0 0 0 0 0 0 0 0 3.09304 0 0 0 0 A0A8C0MEV4 A0A8C0MEV4_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AEAKWASMLSKH;AVSKGGSLPQRGSIGSHQSVRI;ESPDEAALVYAARAY;ETFAQGHLL;KQCRSVLCCRSTPLQ;PREAILEGCSGASKMKPTS;QCLHYVKSKSPCSTPQKTEGNVSVG;RLLIVHGHWC;YWTMQTLL 9 9.8 1.0036 -1.0558 10.3941 0 0 6.92754 9.35663 0 9.18765 0 10.2753 0 8.02862 7.70127 0 0 0 A0A8C0MEV7 A0A8C0MEV7_CANLF F-BAR domain only protein 2 FCHO2 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905] EQMKAFWKLS;KQCETSQGVSRGPS;NYNAKCVEQERLKKEGATQR;PGGCGCGP;SLIQKFAESKG;VLYHNMKHGQ 6 8.3 1.0031 -2.4829 0 8.85646 0 9.12505 7.87055 0 0 0 0 0 0 0 0 12.1421 8.45455 A0A8C0MEV8 A0A8C0MEV8_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] GAHFLGGV;TDTCYSLCMTPKLIA 2 9.9 1.003 -1.3853 0 0 0 0 10.2722 0 0 0 0 0 10.4082 10.6473 0 0 0 A0A8C0MEV9 A0A8C0MEV9_CANLF "N-alpha-acetyltransferase 35, NatC auxiliary subunit (Protein MAK10 homolog)" Canis lupus familiaris (Dog) (Canis familiaris) NatC complex [GO:0031417] EQQKGRSSKKTKKKKK;MSQAYQNMCAGMF;RVKFTRVLLTVLIA;VPPEFDFS 4 7 0.98606 -0.41707 9.85795 0 0 0 0 0 0 4.04116 0 0 0 0 0 5.1811 11.9923 A0A8C0MEW5 A0A8C0MEW5_CANLF Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (Zinc finger with UFM1-specific peptidase domain protein) ZUP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872] AVEGVLSSEE;DEMCFHIETAHFEQ;EALYRYYQ;GYRNFQMLLSSLL;LTQSFKKIFNF;QEMGEFQKL;SGGYKQQQ;VEGVLSSEE 8 11.4 1.0034 -2.0623 0 0 0 0 0 8.79938 0 9.87966 9.52896 0 0 0 9.43143 4.35952 9.90145 A0A8C0MEY1 A0A8C0MEY1_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DELLPVVD;LLEQVQPLIRRDCNYSNLE;LMLSRSDSENI;NKDLKEKHKRRKR;SMEAQRVLREAGQGPE;TLSTLRYANRAKSIKNKP 6 8.4 1.0021 -1.3613 0 0 8.69467 0 7.30086 3.77589 0 0 0 0 0 0 9.53278 0 0 A0A8C0MEZ0 A0A8C0MEZ0_CANLF Anoctamin ANO9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AALFNSTL;DLFLQMAIIMGLKQ;GWDEDQEEMALQLINHRDYQLRPHQ;SVLMICLM;YSLSEQFWVLL 5 9.2 1.0045 -0.81649 0 9.48617 0 0 10.0151 0 0 0 9.92593 0 0 0 9.83488 0 0 A0A8C0MF05 A0A8C0MF05_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GVQPCLSWYI;RVEARRERWEQRQQWRRQRPRRLSQ;TRTCPTDPLRIPTQTW 3 3.6 0.94635 0.084771 10.6763 0 0 0 0 0 0 0 0 0 0 0 0 0 3.76977 A0A8C0MF34 A0A8C0MF34_CANLF Calnexin CANX Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] endoplasmic reticulum membrane [GO:0005789]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966] calcium ion binding [GO:0005509]; unfolded protein binding [GO:0051082] EDMDGEWEAPQIANPKCESAP;GVWQRPMIDNPNYKGK;IMEGKWLLCM;PNYQGIWKPRKIPNP;VGQMIEAAEERPWL 5 13.7 1.0016 -1.3148 9.6355 7.92368 10.192 0 0 0 0 0 0 0 0 0 10.7872 9.52454 0 A0A8C0MF41 A0A8C0MF41_CANLF Peptidase C1A papain C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] cysteine-type peptidase activity [GO:0008234] CCCCCCAGPAQ;CCCCCCCCA;CCCCCCCCAGP;CCCCCCCCAGPA;CCCCCCCCAGPAQP;CCCCCCCCCAGPAQ;CCCCCCCCCAGPAQP;CCCCCCCCCAGPAQPR;CCCCCCCCCC;CCCCCCCCCCA;CCCCCCCCCCAGPAQPR;CCCCCCCCCCAGPAQPRATFTA;GAGGAGRA;LCCCCCCCCCC;LCCCCCCCCCCAGPAQ;LLCCCCCCCCC;LLCCCCCCCCCCA;LLCCCCCCCCCCAG;LLCCCCCCCCCCAGP;SYNNYGCSGG;VVDAVSWQDYLGGIIQHH;WLLCCCCCCCCCC 22 13.9 0.99236 -0.042482 0 0 9.3599 0 4.59024 0 0 6.31208 3.48761 0 3.8745 6.16774 6.98698 0 0 A0A8C0MF45 A0A8C0MF45_CANLF Tight junction protein ZO-3 TJP3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] APWDKATHPTSCRCCWCC;ATHPTSCRCCWCC;CCWCCCCRLV;DLREQERGIIPNQSRAEQLA;PTSCRCCWCCCC;SCRCCWCCCC 6 4.2 1.0035 -1.0683 0 3.84298 0 0 0 6.63939 0 3.62515 0 0 3.20017 5.5391 0 10.2681 6.3181 A0A8C0MF48 A0A8C0MF48_CANLF Ubiquitin-protein ligase E3A (EC 2.3.2.26) UBE3A Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502] ubiquitin protein ligase activity [GO:0061630] IIAKNGPDTERLPTSHTCFNVLLL;LDCRKPLIPF;LVRLEMIAMENPAD;VLEMDKDYTFF;VRQPRLRGPRP 5 7 0.9803 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 5.16619 0 A0A8C0MF49 A0A8C0MF49_CANLF "Stum, mechanosensory transduction mediator homolog" STUM Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AASSSSGV;AIVMVGWIMSIFWGM 2 18.1 1.005 -1.0496 10.381 0 0 0 0 0 0 0 0 0 0 10.7903 0 0 0 A0A8C0MF54 A0A8C0MF54_CANLF Thioredoxin-related transmembrane protein 2 (Thioredoxin domain-containing protein 14) TMX2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966] PQIDKKGRAVSW;PTQREDGNPCDFDWR;RAVSWTFSEENVIRE;RVTWIVEFFAN 4 18.6 0.99647 -0.11292 0 0 0 0 0 0 0 0 0 0 0 8.58323 0 9.56238 9.56024 A0A8C0MF78 A0A8C0MF78_CANLF Crumbs cell polarity complex component 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AAGGGGAA;AALLLLPLLLAPALTL;APAGMRGG;ASRPLAALLLLPLLLAPALTLL;CGDAGMRGMRGCGDAG;CGGCGGCGG;CGGCGGCGGCGDAGGC;CGGCGGCGGCGDAGGCGVCGGG;CGGCGGCGGCGDAGGCGVCGGGGGC;GARAARPAPTPAAPRPVPA;GCGGCGGCGDAGGCGVCGGGGGCGG;GCGGCGGCGGCGDAGGCG;GFEGDECGVDVDECASRPCLN;GGCGDAGGCGVCGGGGGCGGGP;GGCGGCGGC;HGAFCGQNTT;KPRGGRFPSRSLGA;LAALLLLPLLLAPAL 18 11.8 1.0037 -1.5979 7.18884 7.93729 10.7152 4.02839 5.04273 6.13972 7.72288 5.59837 3.94944 0 0 3.55937 0 7.66491 0 A0A8C0MF82 A0A8C0MF82_CANLF Transmembrane protein 63C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium-activated cation channel activity [GO:0005227] EQASIRFQC;GGCGGGLAREQQDS;IHMAAVYQAIF;LFFSILRLGTLH;VTRTLMITYVPKDIQDPE 5 6.3 0.9866 -0.39522 9.56942 0 10.8514 0 0 0 11.0604 0 0 0 0 0 0 0 0 A0A8C0MF90 A0A8C0MF90_CANLF NEK6-subfamily protein kinase (EC 2.7.11.34) NEK6 Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of mitotic metaphase/anaphase transition [GO:0030071] centrosome [GO:0005813]; cytosol [GO:0005829]; spindle pole [GO:0000922] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ALVRLACRMAG;DNELNIVLELADA;GPKAGAKP;LDRKTVALKKVQI;MHRDIKPA;PERTVWKYFAQL 6 13.4 1.0028 -1.5071 5.47031 0 0 0 0 0 11.9812 0 0 8.10324 0 0 0 0 15.1926 A0A8C0MFA0 A0A8C0MFA0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FFSPSIFF;KQLVVQEALLTILREL 2 9.8 1.004 -1.1044 0 0 0 0 0 0 0 0 0 8.19234 0 0 0 0 0 A0A8C0MFA5 A0A8C0MFA5_CANLF polynucleotide adenylyltransferase (EC 2.7.7.19) TENT5A Canis lupus familiaris (Dog) (Canis familiaris) mRNA stabilization [GO:0048255] poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] GGGGGDDD;HCNVLNWEQVQRLDGIL;VLADQNVIPNVANVTCYYQP 3 10.4 1.0028 -1.0079 0 7.10497 0 0 0 0 0 0 10.5766 0 9.14853 0 0 0 0 A0A8C0MFC2 A0A8C0MFC2_CANLF Cytochrome P450 family 39 subfamily A member 1 Canis lupus familiaris (Dog) (Canis familiaris) bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632] membrane [GO:0016020] heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid 7-alpha-hydroxylase activity [GO:0008387] LYIYTLKMYQI 1 2.4 0.98027 0.035491 0 0 1.63659 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MFD9 A0A8C0MFD9_CANLF ArfGAP with dual PH domains 1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096]; phosphatidylinositol bisphosphate binding [GO:1902936] AGSPRRSRARKEA;DNSTRNIFV;EDGKEIVDWFNAL;HGLQVTYLKDNSTRNIFVYHED;VDWFNALRAARFHYLQ;YRPTFSDCQLLR 6 12.8 1.0009 -0.62629 0 7.78679 6.99288 0 0 0 12.3017 10.409 0 0 0 0 0 0 0 A0A8C0MFE4 A0A8C0MFE4_CANLF DENN domain containing 4C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] EAFEVKSEPF;EVLMSSCSQ 2 1 1.0015 -0.94701 0 0 0 0 0 0 0 0 10.9524 0 0 0 0 0 0 A0A8C0MFE6 A0A8C0MFE6_CANLF Dishevelled binding antagonist of beta catenin 2 Canis lupus familiaris (Dog) (Canis familiaris) TLPPGHCA;VDTSWDTL 2 2.4 1.0033 -1.615 0 0 0 0 0 0 3.54868 0 0 0 0 0 8.73559 0 0 A0A8C0MFF0 A0A8C0MFF0_CANLF S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) BMT2 SAMTOR Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] FKYSKFSHMHL;GGGGGGGD;IWREHCEDEETLCEYAVAM;WREHCEDEETLCEYA 4 6.5 0.97901 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.30483 A0A8C0MFF9 A0A8C0MFF9_CANLF GDP/GTP exchange factor Sec2 N-terminal domain-containing protein RAB3IP Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] LHPAHPSTQRTPL;VECGGPKKCA 2 3.7 0.9864 -0.2459 0 0 0 0 0 0 0 0 0 0 0 0 0 5.39166 0 A0A8C0MFG2 A0A8C0MFG2_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase) MGRN1 Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; protein ubiquitination [GO:0016567] early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DLNFLGNRPVQFPYVT;GEKFDTPHPEGYLFGENM;GVSDGLSQASCPL 3 8.6 0.86757 0.16171 0 0 0 0 10.2836 0 0 0 0 0 0 8.53041 7.88947 0 0 A0A8C0MFG3 A0A8C0MFG3_CANLF Proline rich coiled-coil 2A PRRC2A Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EPTPPGSRPLPWPPGSDEATKIQ;ETGSETHESDL;GGGGGGPG;GVEDGERPRRRR;PKRRERPP;QQQDKPPRFRRLKQ;SDSGGSNS;SSSGGGGG;VSGGGSTS 9 4.4 1.0031 -1.7403 8.50224 6.96371 0 0 10.1273 0 11.383 0 0 9.02517 0 0 0 11.1838 0 A0A8C0MFG4 A0A8C0MFG4_CANLF Dihydroorotase TRIM54 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; UTP biosynthetic process [GO:0006228] cytosol [GO:0005829] amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; metal ion binding [GO:0046872] AQTNYLYLTYWGTTHDLTFRTPHVL;EVAGFGESRC;GGRGGGGG;LPNNMAMALH;LVQDGTEPSALP;NKGLMCSD;PVETIELTEDR;SVTGGTAAFEPS;TGFKIPKKNILLTIGS;VGYPCVVRPS;VHSGDATL;VIMGEEVEPVG;VLGTPVETIELTEDRRAF 13 6.3 0.98931 -0.26592 0 0 0 0 9.61237 0 0 0 0 0 0 0 0 0 0 A0A8C0MFH8 A0A8C0MFH8_CANLF Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EAMEHPYFWIS;ESHVVEWGNQ;ILKPVKKKKIKREIKILE;ILKPVKKKKIKREIKILENLRG;KILKPVKKKKIK;KILKPVKKKKIKREIKILE;KVVVKILKPVKKKK;KVVVKILKPVKKKKI;KVVVKILKPVKKKKIK;KVVVKILKPVKKKKIKR;LKPVKKKKIKREIKILENL;NEKVVVKILKPVKKKKIK;PVKKKKIKREIKILEN;TDFKQLYQTLTDYDIRFYMYEILK;VKILKPVKKKKI;VKKKKIKREIKILENL;VVKILKPVKKKKIK;VVKILKPVKKKKIKREIKI;VVKILKPVKKKKIKREIKIL;VVVKILKPVKKK;VVVKILKPVKKKK;VVVKILKPVKKKKI;VVVKILKPVKKKKIKR;VVVKILKPVKKKKIKREI 24 20.4 1.0032 -0.85866 9.86983 0 0 0 0 0 0 0 0 8.74046 0 0 0 0 0 A0A8C0MFH9 A0A8C0MFH9_CANLF Transforming growth factor-beta-induced protein ig-h3 TGFBI Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] LVRLLPVALALALG;TLEVGCSGDMLTINGKAI;VISYECCPGYEK 3 6.4 0.98624 -0.41077 0 0 0 9.71884 0 6.24142 10.1179 0 0 0 0 0 0 10.5881 0 A0A8C0MFK2 A0A8C0MFK2_CANLF GP-PDE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291] endoplasmic reticulum membrane [GO:0005789] lysophospholipase activity [GO:0004622]; phosphoric diester hydrolase activity [GO:0008081] NTPINIDIKVNN;PAARARLRT;PNTPINIDIKVNNN 3 5.9 1.0023 -0.98936 0 0 0 5.26664 0 0 0 0 0 0 9.55357 0 0 0 0 A0A8C0MFK8 A0A8C0MFK8_CANLF PNMA family member 8A Canis lupus familiaris (Dog) (Canis familiaris) LEADGAEDME;NRSRRKKQRKNP;VGCGAGCK;VLMPWLLS 4 6 1.003 -1.3374 0 0 0 0 0 0 8.4099 9.49546 9.4651 1.59101 0 0 6.18128 8.54299 0 A0A8C0MFL0 A0A8C0MFL0_CANLF Retrotransposon Gag like 1 Canis lupus familiaris (Dog) (Canis familiaris) AALLVLLKLK;EQLEEEPETSEFM;EQTGKRVSCAFYSR;HPPRVRSAYGQPDPVAQ;LLVLLKLKRRL;NPYHSVAVQALVD;PMVLQPLRHLPV;TLAVAALLVLLKLKRRL;VGTSAVPAQ 9 7.2 1.0018 -1.3655 0 0 10.6454 7.51475 0 0 0 8.54493 9.5142 0 0 0 0 0 9.28228 A0A8C0MFM7 A0A8C0MFM7_CANLF Ribitol-5-phosphate transferase Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein metabolic process [GO:0009100] AAPVSPSWCGSSR;RTQPSRWWWPR 2 5.1 0.99051 -0.51098 0 0 0 0 0 0 11.8297 0 0 0 0 0 0 0 0 A0A8C0MFM8 A0A8C0MFM8_CANLF Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Fatty aldehyde dehydrogenase) Canis lupus familiaris (Dog) (Canis familiaris) cellular aldehyde metabolic process [GO:0006081]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789] 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029] AEEGLARCPAGANLG;AEEGLARCPAGANLGG;GVEETTELLKQRFDHI;IAAGNAVIIKP;MLDEAYVQPEPLG;RDRAMESRIQ;TANDVIMHFTLSSL;VLVKKYQAVLRRKALLS 8 14 0.99539 -0.56356 10.4795 2.13086 0 0 0 10.353 0 7.73789 7.76168 9.73169 0 0 0 0 0 A0A8C0MFN0 A0A8C0MFN0_CANLF Ig-like domain-containing protein TMEM25 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAAPASPSELRYPPPFT;GGGGGGGA;SPRGGGGGG;VTVNTSDFLVL 4 5.7 0.99696 -0.11075 11.8332 0 0 0 13.6315 0 0 0 0 0 10.9745 0 6.06512 0 0 A0A8C0MFN8 A0A8C0MFN8_CANLF Olfactomedin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LLLLPPVLLLLLLPPRAGRVRADTK;PRPRPLLLLLLPPVLLLL;PRPRPRPRPRPLLLLLLPPVL;RPLLLLLLPPVLLLLLL;RPQLPFLNEHAY;RPRPLLLLLLPPVLLLLLL;RPRPLLLLLLPPVLLLLLLPPRA;RPRPRPLLLLLLP 9 10.1 0.99472 -0.12613 0 0 0 0 5.09149 5.41562 4.36912 0 0 4.37879 0 5.98696 0 8.00191 6.05239 A0A8C0MFQ1 A0A8C0MFQ1_CANLF Histone H2A H2AZ2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] PVGRIHRH;VGRIHRHLKTRT 2 19.7 0.99396 -0.13248 0 7.26407 0 0 9.40146 0 0 0 0 0 0 9.39069 0 0 9.75156 A0A8C0MFR8 A0A8C0MFR8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YGSACSGL 1 4.1 0.99057 -0.26592 0 0 0 0 0 0 0 0 7.77696 0 0 0 0 0 0 A0A8C0MFS1 A0A8C0MFS1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRK Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AEIQARRIAVDWESLGYNITRCH;AGISAGILVFILLLLVVILIV;FILLLLVVILIVKK;FILLLLVVILIVKKRR;GILVFILLLLVVILIVKKRRS;ILLLLVVILIVKK;ILLLLVVILIVKKRRS;ILVFILLLLVVILIVKKRRS;LDPNGVITQYEVSYSSI;LVFILLLLVVILIVKKR;LVVILIVKKRR;QVECMSCSMD;QVECMSCSMDC;SWTETHAVNAPTYKLWHL;TPKSSVNFRSL;TVSNLWNST;VECMSCSMDC;VECMSCSMDCDV;VFILLLLVVI;VFILLLLVVILIVKKRRSYYSYS;VINRIFRICNLTR;YHQDLYDDFEWVHVS;YHYFRGHNESK 23 10.7 0.64919 0.32181 0 0 0 4.32431 6.74295 0 8.78741 0 0 0 0 0 0 5.77339 0 A0A8C0MFU0 A0A8C0MFU0_CANLF RB transcriptional corepressor like 2 RBL2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] ARSPAPQTQQRFDE;DELRKKIWTCFEF;EDFSNSKE;FFNKMKKWEDMANLPPHFRERTER;HWLACALYV;LHTMLTGLRN;LYEKKLLKGKEENLTG;NFGESFKAINKAYEEYVLS;PAKRICPENHSAL;PSSDPPCVIEKLCSLHDGLVLEA;TSRDSSPVMRSSS;VLESVIEQE 12 15.6 1.0032 -2.3738 0 11.2559 9.59828 0 9.88807 0 0 8.72288 8.56727 0 7.54094 0 0 8.51546 0 A0A8C0MFY5 A0A8C0MFY5_CANLF Olfactory receptor LOC119864123 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NSTVNEFI 1 2.6 0.99354 -0.16987 0 9.94218 0 0 0 11.0804 0 11.893 0 0 0 0 0 0 0 A0A8C0MFZ3 A0A8C0MFZ3_CANLF AAA+ ATPase domain-containing protein DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DEFNRIEVEVL;DTYYIPPHGSYQS;EEKLVRVQEILD;ETARMMVKIEEE;FQEWIDNGPPVVFWISGFY;FVVQVSELIIP;ITKNYSSYDWRE;NESDLRISMQQV;PGPGSCPE;SEDNICDLNDFQW;TVSRCGMI;VRHGYMIVGDP;VTPTSYLELILTFKTL 13 4.9 1.0024 -1.4059 0 0 0 0 0 0 0 0 7.22217 0 0 0 0 0 0 A0A8C0MG23 A0A8C0MG23_CANLF Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) CHD8 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of DNA-templated transcription [GO:0045893]; Wnt signaling pathway [GO:0016055] MLL1 complex [GO:0071339] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039] DEDEDDDDDLSQ;DLVEFSDLESE;EIWLKNPLDKKPVIY;GPPKDQDDEGDPLMMMDEEI;GVEYDPDTMQFHW;KNRNQLREYQLEGVNWLLFNWYN;LEDRLALCQ;PEEDEDDEDEDDDDDLSQGY;PHHHHHHHPG;PQQKIQIVPQPP;QGGGTGSL;SAPHTGGKIGMEENRRLEH;SGGPQGHR;STDESEDEKEEK;TIALLCCSGPVSSGVSPSSSEDL;TSGTSKTKGKSKLNTITP;VEELFSLLHFLEPSQFP;VEGVDFDKDCEDP;VELEVQCMEEPNH;VLQSMSGRDGNITGIQQ;YRVVSTFGVEYDPDTMQFH 21 11.7 0.99755 -3.5441 10.7683 9.44508 15.5637 9.35337 9.44035 9.29391 7.38776 0 11.1658 0 14.3663 10.7189 8.44377 9.76019 8.1953 A0A8C0MG44 A0A8C0MG44_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LQVTDINDNPPVFPQNSY;NDNTPQFQLE;QKKKKRRRKQKHGKV;RYVVPEETEK;VIVLLALRLRRWHASRLL 5 8.2 0.9508 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.95317 A0A8C0MG51 A0A8C0MG51_CANLF BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) BAIAP2 Canis lupus familiaris (Dog) (Canis familiaris) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ruffle [GO:0001726] cytoskeletal anchor activity [GO:0008093] ASSPQRLSAQESTP;DVLFQMAEVHRQIQNQLEEML;GVSLQLPASFLGVERCPP;KYSDKELQYIDAISNKQGELENYV;LVPEARDGWHYG;TEQRSKGDALDK 6 17.6 0.66409 0.30918 7.7187 8.00034 0 0 0 0 9.59184 7.71363 0 0 0 0 0 9.28209 0 A0A8C0MG67 A0A8C0MG67_CANLF Rho guanine nucleotide exchange factor 40 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] EALALEEDAASQKVLDVFEQRLEQ;EQGQLLHRDPFTVICGRKK;GAELLSESDL;LEGPGPAAVYQ;PLETAQEVGGASVPEEASPVSI;SQSSPEPEPVEDCV;VLSTALRYLHSL 7 6.3 1.0029 -0.80132 0 10.268 8.85356 8.75989 0 0 0 0 0 0 7.34802 0 0 0 0 A0A8C0MG76 A0A8C0MG76_CANLF Family with sequence similarity 219 member A Canis lupus familiaris (Dog) (Canis familiaris) DDDFDMSRYSSSG;IPPNQVSPCSLIYFQ 2 17.1 0.86612 0.14473 0 0 0 10.2515 0 0 0 0 0 0 0 0 0 3.02924 0 A0A8C0MGA7 A0A8C0MGA7_CANLF EF-hand domain-containing protein EFCAB6 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] calcium ion binding [GO:0005509] IERTFCQELPKC;ISDSEFKELMQM;IVLDTFVYRLPRRIF;QEFLQKLGINY;RRIFIQLMKRITSRD 5 4.2 0.9932 -0.029441 0 0 7.23016 0 0 0 0 0 11.7736 0 0 0 9.02636 0 9.23477 A0A8C0MGE0 A0A8C0MGE0_CANLF "Beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.244)" PKP3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] AAWLTYVHLSLV;FEDWCGGAVGHLRRNLHFPLFPHT;FPVKKVRKQIKLLLLLLLL;KKVRKQIKLLL;KKVRKQIKLLLLL;KKVRKQIKLLLLLLLL;KVRKQIKLLLLLL;KVRKQIKLLLLLLLL;LLLLLLLL;LLRSDWNDLRC;PRPRRGRCVDA;PVKKVRKQIKLLLL;RKQIKLLLLLLLL;RTGNFERSAGLQAGVDAVEDA;VGKTGSEWTAPGEFTKFSSQVSK;VKKVRKQIKLLLLL;VKKVRKQIKLLLLLL;VKKVRKQIKLLLLLLL;VRKQIKLLLLLLLLTCA 19 10.7 0.1028 0.8574 5.93204 8.40271 8.12226 6.37302 6.05572 6.04721 4.78623 8.56769 9.56444 0 5.33342 2.75363 0 0 9.21352 A0A8C0MGE5 A0A8C0MGE5_CANLF Mitochondrial import receptor subunit TOM5 homolog TOMM5 Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to mitochondrion [GO:0006626]; protein transport [GO:0015031] mitochondrial outer membrane translocase complex [GO:0005742] RKMREDVI 1 15.7 1.0032 -1.1044 0 0 0 0 0 0 0 8.57312 0 0 0 0 0 0 0 A0A8C0MGE8 A0A8C0MGE8_CANLF Endonuclease (EC 3.1.30.-) Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] NVAPQVPHLNQ 1 3.9 0.98132 0.035491 0 0 0 0 0 0 0 10.5719 0 0 0 0 0 0 0 A0A8C0MGF1 A0A8C0MGF1_CANLF Centrosomal protein 128 CEP128 Canis lupus familiaris (Dog) (Canis familiaris) DLQISELTH;DWRFRRGVEQEK;IQNHFETCEAKHKRADLQ;LFEQIERQEQ;QLRSQRLLRHSG;WMERVHSLK 6 6.5 1.0048 -0.80421 0 0 0 0 0 0 0 0 8.80507 0 0 0 0 2.87377 0 A0A8C0MGG6 A0A8C0MGG6_CANLF Uncharacterized protein C17H1orf54 Canis lupus familiaris (Dog) (Canis familiaris) EPSPDLNDAVSSLQ 1 10.7 0.94675 0.078799 0 0 0 7.23439 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MGI5 A0A8C0MGI5_CANLF Importin N-terminal domain-containing protein IPO7 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytosol [GO:0005829]; nuclear envelope [GO:0005635] small GTPase binding [GO:0031267] AEHENDSDDDDEAEDDD;AEHENDSDDDDEAEDDDETEEL;CYTDADEELWQEDPYEYI;EDWEEDDAEETALE;KKIYKDQMEYMLQ;VEMTQHLAMTFNQVIQ 6 8.4 0.66279 0.31111 7.20242 4.7658 0 0 0 0 9.80122 0 0 0 0 0 6.73091 8.13186 0 A0A8C0MGJ1 A0A8C0MGJ1_CANLF MAP7 domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] RRQARLQKEQEEQERLEKEEQDRLE;SVFLERLEAMMRRS 2 9.7 0.92975 0.09647 0 0 8.09782 0 6.30941 0 0 0 0 0 0 0 0 0 0 A0A8C0MGQ3 A0A8C0MGQ3_CANLF General transcription and DNA repair factor IIH helicase/translocase subunit XPB (EC 5.6.2.4) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) ERCC3 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853] DKIIVFADNVFAL;IPTDLFDFYEQMDKDEE;LVREDDKIVDLNF;NFKHNPKINTI 4 7.1 0.98652 -0.24588 0 0 0 0 0 0 0 2.86977 11.0891 0 8.90265 9.96067 0 0 15.0875 A0A8C0MGR5 A0A8C0MGR5_CANLF Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] protein tyrosine phosphatase activity [GO:0004725] ADHEVPQSQPIKLGD;ATDYSDRGDSDMDEATYSSSQDH;DFELEVELLITLI;DLEFDISDLVRCMRLQRHGMVQ;DPALLTPLHSPA;ESNVQEDDIYDDP;LLLGRVLELPRMPVL;PLDMKSTEYRFDYEMMI;PSPLPPNTTLGQS;QSQRPSRQYETPL;TLHSSGNPSSQVPL;TQGMTLEEAKRALDMSL;VKALTKIP;VRLLLGRVLELPRM;YFKDISSDNNSGHEDSENASS;YQPLQNNAKEKSDKTSWEEKPRG 16 9.5 0.99319 -0.27874 0 0 0 0 0 0 0 0 0 0 0 7.51751 0 0 0 A0A8C0MGT0 A0A8C0MGT0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GAPRAGRAFRRGPGG 1 3.8 0.95033 0.05389 0 0 0 0 0 0 0 0 0 0 0 0 8.69919 0 0 A0A8C0MGT2 A0A8C0MGT2_CANLF F-BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVRCPLPGLQGPVHSSA 1 3.7 0.98444 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 7.76308 7.53504 0 A0A8C0MGU6 A0A8C0MGU6_CANLF Protein phosphatase 4 regulatory subunit 1 PPP4R1 Canis lupus familiaris (Dog) (Canis familiaris) ADGFGVDDYSSESD;CEMCCDCRWFHV;DFVSQDEMLTPLG;DTLREVCDDERDCIAVLE;LILPRFCEMCCDCRW;LQEDADGFGVDDYS;VGQQATEEMLLPRFFQ 7 8.7 1.0025 -0.8975 9.97068 8.867 10.8086 0 0 9.47419 0 0 0 0 0 0 5.63081 0 0 A0A8C0MGU7 A0A8C0MGU7_CANLF Ring finger protein 213 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] DLFLDGVSLRKT;EKFNIPLSNSDL;EKHYLDINTVLE;GKPRITLMGIPTL;GLSKKLVEIF;ICMETGKMVVLLNLQ;KLHETICSITKDE;LALGDWHQ;LEELWVQAQYITGAE;LGDWHQYDDMVRM;LLTHLALL;LVSYMETKDSEIPPELEY;NLSRILTIYPQILQVL;PEDLLVQARNWKGLET;PLEGAGPPG;PYIMVHNDMSP;SDGCKALSVIEVTLGFLSTAGG;SLDAIHPSSGRVI;TYSMWCSPEP;VEYLQEMTRIRLCLNKAS;VIDPSWSELQNFAGF;VIMDGVRDEDLAPFSLRK;VLDRDSNLE;VLHMALWSCINQLHTQRP;VLPAALAIYRHM;VMHTLCKCKEQAS;VPLKVIRLI;YSMWCSPEPASEA;YTAEQLVYLSTQLKEQKP 29 7.3 0.94868 0.05044 0 5.22747 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MGU8 A0A8C0MGU8_CANLF Glycosyltransferase 2-like domain-containing protein B4GALNT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPAAAERGAR;LVPGLSLQAASGQELYQVN;SPLQYPLQ;WLPPRARGLSRLRGH 4 7.4 1.0026 -0.98023 0 6.69585 0 0 0 0 7.59589 9.7908 10.3172 0 0 0 8.97327 0 0 A0A8C0MGV1 A0A8C0MGV1_CANLF Inactive serine protease 35 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] FPFNTAVKLSTGCSG;RVKIQDVVLE;YDYALLELKRA;YETVFENGTRTL 4 13.5 1.0025 -0.75942 9.40752 0 0 0 0 0 10.2015 8.7254 0 0 0 0 0 0 7.81609 A0A8C0MGV5 A0A8C0MGV5_CANLF 40S ribosomal protein S27 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735] TESLISSVIP 1 12.8 0.98576 -0.25957 0 0 0 0 0 0 10.7474 0 0 0 0 0 0 0 0 A0A8C0MGW0 A0A8C0MGW0_CANLF Rho GTPase activating protein 18 ARHGAP18 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AGDPQESMVFLSTLTR;NEPDEGELEEEWL;RMNQWMRACSRKYGQ 3 6.9 0.99122 -0.13346 0 0 0 0 0 0 7.76911 0 8.41722 0 0 0 0 0 7.03771 A0A8C0MGW6 A0A8C0MGW6_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; disruption of cell wall in another organism [GO:0044278]; positive regulation of cell population proliferation [GO:0008284]; response to peptide hormone [GO:0043434] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] oligosaccharide binding [GO:0070492]; peptidoglycan binding [GO:0042834]; signaling receptor activity [GO:0038023] LHDPQKRQKWQW;SMGENMYCADISAR 2 16.5 0.9966 -0.57234 0 0 0 0 0 0 12.6169 0 0 0 0 0 0 0 0 A0A8C0MGW7 A0A8C0MGW7_CANLF J domain-containing protein DNAJC13 Canis lupus familiaris (Dog) (Canis familiaris) endosome organization [GO:0007032]; regulation of early endosome to late endosome transport [GO:2000641] AIIRPLPRVKRLL;ALMCPMHDDYD;DKLIGPKVRI;DLFISESQTAGYLTGVSPSLLT;EVKYECLAEEI;GDKEIATKMQELALSE;GVKVVKALKR;HLHVSRATVPLQ;HVSRATVPLQS;LPEAMVCYLEN;NRMFQKEQSELVAQALKV;RLAGKAAKEVEKFAKEKVDLV;STTVREMMLEHFKN;VGEIFVRVY 14 8 0.98567 -0.2361 0 0 8.78411 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MGY8 A0A8C0MGY8_CANLF Caspase 8 associated protein 2 CASP8AP2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190] AKLKKILVKF;ASKLNKNPYQVLGFT;CQNGVFKS;DIVKTKDLKSRSPHLD;ESKEESRHMRSEKRTPTEH;HLEPCSPK;KKKLWKFVDEQLDYL;LFAKLKKILV;LVDTPLVENKSYHLEPC;SETNSVYNDDE;VLSFTSLIKHLD 11 6.4 0.99803 -3.329 7.65628 10.1478 9.01695 9.24828 10.0855 0 0 2.20298 0 11.1947 0 0 6.8226 0 4.35931 A0A8C0MH08 A0A8C0MH08_CANLF "Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase)" VARS2 Canis lupus familiaris (Dog) (Canis familiaris) valyl-tRNA aminoacylation [GO:0006438] mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] CIPPPNVTGSL;EDCWVVGRTETE;FVPQPAEELSPSSPT;LTDDVPAPRSS;RAFLARELPL 5 5.5 1.0019 -1.3204 0 0 0 0 11.4932 0 0 9.46293 0 8.86524 0 0 0 0 0 A0A8C0MH13 A0A8C0MH13_CANLF Brain enriched guanylate kinase associated Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFPAGFRHEAFPGYAASL;AGDAPGSP;NSTDSAAEDEEEAEAE 3 5.4 1.0045 -1.1044 0 0 0 0 0 0 0 0 9.22499 0 0 0 0 0 0 A0A8C0MH26 A0A8C0MH26_CANLF proteasome endopeptidase complex (EC 3.4.25.1) PSMB7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] nucleus [GO:0005634]; proteasome core complex [GO:0005839] AALVLGGV;CQCGAMWPCPSTLY;GVDVTGPHLY;TRPLGDALHVEKR;TSCCGAGT;VGGIQRRSRCQC 6 15.7 0.99913 -2.9288 0 0 0 9.14384 8.42874 5.95555 7.12856 0 0 9.21931 0 8.20256 0 9.84229 9.13389 A0A8C0MH58 A0A8C0MH58_CANLF G-protein coupled receptors family 1 profile domain-containing protein ICMT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EDSDNDTSLESGIPP;FYTLTLATCF;GPARASPRAPGGPGRPQGPK;IPPDLVLEHSLDY 4 8.7 0.95354 0.049325 0 0 0 0 0 0 0 7.4847 0 0 0 0 0 0 0 A0A8C0MH65 A0A8C0MH65_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CSCGNCECWD;ELCDCDDRDCDKHDGL;GHGTCSCGHCVCETGW;SGELCDCDDRDCD;TCVCGECSCHDVDP;VYGKFCECDDRECIDDETEE 6 19.5 1.002 -0.68428 6.61555 0 0 0 0 0 5.47281 7.24527 7.15147 0 0 0 0 0 7.26538 A0A8C0MH70 A0A8C0MH70_CANLF Corneodesmosin CDSN LOC119876865 Canis lupus familiaris (Dog) (Canis familiaris) skin morphogenesis [GO:0043589] extracellular region [GO:0005576] NPVKGSPGAPSF;SGSSGSSSSSSSGSSGGLS;SIYQSGASSAIVFQ 3 9 0.98646 -0.45076 9.04636 0 0 0 0 10.4105 0 0 0 0 0 0 0 9.26938 0 A0A8C0MH79 A0A8C0MH79_CANLF RRM domain-containing protein RBM34 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AVLIKKKKKK;AVLIKKKKKKGQKKSG;DSAARLASLFSSSEPQLQ;FVGNLPYKVEESAVEEH;IKKKKKKGQ;KAVLIKKKKK;KAVLIKKKKKKGQ;KAVLIKKKKKKGQKK;LFIGEKAVLIKKKKKKGQK;LIKKKKKKGQKKSGH;LSKKLAAIKRKI;VLIKKKKKKG 12 17.2 1.0028 -2.5083 0 6.49347 4.09643 0 0 7.71884 0 0 0 0 7.14527 8.80616 0 0 0 A0A8C0MH80 A0A8C0MH80_CANLF protein acetyllysine N-acetyltransferase (EC 2.3.1.286) SIRT6 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone H3K9 deacetylase activity [GO:0046969]; transcription corepressor activity [GO:0003714]; transferase activity [GO:0016740] GSAPPARPISGGS;SITLGTSLQIRPS;VLERALPPLPRPPAPKPEPK 3 11.7 0.98948 -0.52114 0 0 5.04941 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MH86 A0A8C0MH86_CANLF TBC1 domain family member 9B Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] ASPLASDLDLFLPWEAQ;IELCKTLYNMFSEDPMEQDL;LDNVVNKQSVSPPI;PYRILHQTQDSQVYWTVAC;TAVRRDPSLPYLEQYRIDA;TVALPPGG;WTVACGSSRKEITKHWEWL 7 7.7 0.98898 0.019486 0 0 10.8132 0 9.61134 0 0 9.85425 7.54133 10.0783 6.96371 0 0 0 0 A0A8C0MHC8 A0A8C0MHC8_CANLF "Beta-1,4-mannosyltransferase (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase)" Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] mannosyltransferase activity [GO:0000030] AEELAGQLQMLFSKFPDP;NLCVTNSMRED;YTIMGLVHG 3 10.8 0.99111 -0.29401 0 0 0 0 0 0 0 0 8.49582 0 0 0 12.3263 0 0 A0A8C0MHE6 A0A8C0MHE6_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; transferase activity [GO:0016740] FIDLNYMVYMFQTG 1 3.5 0.93855 0.060769 0 0 0 0 0 0 0 0 0 0 7.63307 0 0 0 0 A0A8C0MHG2 A0A8C0MHG2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAVMTQTPLSL 1 10.7 0 9.7753 14.1472 13.9183 13.8941 10.3932 12.5865 12.2539 14.1355 13.9559 13.981 14.3013 14.3967 14.3721 0 0 13.7888 A0A8C0MHG9 A0A8C0MHG9_CANLF IGF like family receptor 1 IGFLR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLSCTSSSSSSQV;PRHGLPRGGSEGVPPGPLPAG 2 8.1 0.99113 -0.19462 10.0293 0 0 0 0 0 0 9.35716 0 0 0 0 0 0 0 A0A8C0MHI2 A0A8C0MHI2_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721] ESMTIEDEYSGPKLE;PYVSERKDSPFLYASRV;TEKITVCGDTHGQFYDLLNI;VFEWLPLA 4 10.8 1.0021 -0.65622 0 8.4763 0 0 6.58928 0 0 0 0 0 0 5.17572 0 0 0 A0A8C0MHI3 A0A8C0MHI3_CANLF Ring finger protein 112 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; metal ion binding [GO:0046872] AGPRAICWHPGAPLAAGVQQN;APIRLLSLHPSS;CAGPRAICWHPGA;VGAGPHGPGGRRGGRGHGSGRAGRR 4 6.2 1.0014 -0.70762 0 0 13.7861 0 0 8.93967 10.7403 0 8.03766 0 0 0 0 0 0 A0A8C0MHI7 A0A8C0MHI7_CANLF Integrator complex subunit 5 Canis lupus familiaris (Dog) (Canis familiaris) integrator complex [GO:0032039] AVMSPALLGTVSG;GPKAGAKP;SAHLSDLAPLLLHPE;SCPDACVD;TVERDLRIGRRFREQPLLF;TVPFLLQLA 6 7.1 1.0022 -1.4241 9.12709 9.34501 0 0 0 0 9.37313 0 0 0 0 9.41115 9.65422 0 9.60668 A0A8C0MHK2 A0A8C0MHK2_CANLF Fibroblast growth factor receptor substrate 3 FRS3 Canis lupus familiaris (Dog) (Canis familiaris) fibroblast growth factor receptor signaling pathway [GO:0008543] membrane [GO:0016020] fibroblast growth factor receptor binding [GO:0005104]; identical protein binding [GO:0042802] EEAGDDGD;QVELKGWGGDRPKG 2 4.4 1.002 -1.2337 0 0 0 0 5.33167 0 0 0 0 8.7659 0 0 0 0 0 A0A8C0MHK8 A0A8C0MHK8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVMAAWVGGAVH 1 3.9 0.95361 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2279 0 A0A8C0MHK9 A0A8C0MHK9_CANLF Ciliary microtubule inner protein 2C Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DSDRLAQITGFYQMAQEHR;GRGGGGAH;SKRSLTRDRGLH 3 11.2 0.9913 -0.2219 9.56917 0 0 0 0 0 0 0 0 0 0 0 9.97398 0 0 A0A8C0MHP9 A0A8C0MHP9_CANLF ADAM metallopeptidase domain 30 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] IVEENEDCDCGSREEC;IVSIMLLRLIFLVISVIVVFFRR;QFFDHVNSAALC;VGYHKAMIPM;VGYHKAMIPMGIP;YMCREEDNECDLAEY 6 14.3 0.97837 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.07714 A0A8C0MHQ1 A0A8C0MHQ1_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; regulation of translation [GO:0006417] cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] RNA binding [GO:0003723] DDEQALHREPE;EGALARSLSAAHTPVQ;EGRNLKKIEHETGTKITIS;GQEAAPGGTGPA;GTAQGAGR;KEADETKLAEEI 6 7.7 1.0042 -1.1044 0 0 0 0 0 0 11.6712 0 0 0 0 0 0 0 0 A0A8C0MHR1 A0A8C0MHR1_CANLF proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) NNT Canis lupus familiaris (Dog) (Canis familiaris) proton transmembrane transport [GO:1902600] membrane [GO:0016020] oxidoreductase activity [GO:0016491] DTDLVLVIGANDTVNS;MIYPQGNL;THQALWCKAPVKPG;TVAELEAEKAATVT 4 4.7 1.0005 -0.92969 0 0 0 0 8.84536 0 0 0 11.9564 0 0 0 0 0 9.31179 A0A8C0MHR4 A0A8C0MHR4_CANLF Protein MON2 homolog MON2 Canis lupus familiaris (Dog) (Canis familiaris) EFVGQIMTMLN;LREEFSKMCFETLLQ 2 1.7 0.94079 0.10026 0 0 0 0 0 9.17916 0 9.73696 0 0 0 0 0 0 0 A0A8C0MHR6 A0A8C0MHR6_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP20 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] centrosome [GO:0005813]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] LFYRKSSEEAVRERQQVVSLAA;YSCERCKKLRNG;YSFKISSHVSFPLEGLDL 3 5.7 0.9874 -0.36094 0 0 0 8.00355 0 0 0 0 14.1315 0 0 0 10.4732 0 0 A0A8C0MHS0 A0A8C0MHS0_CANLF Parvalbumin PVALEF Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] GSAGRGRGGLRGRGRFEGG 1 8.4 0.94967 0.049735 6.31698 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MHT2 A0A8C0MHT2_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FIAESRMLDS;LEVNLQNGILFV;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG 5 6.5 0.99004 -0.26377 0 0 0 0 11.5867 0 0 0 0 0 0 0 0 0 0 A0A8C0MHT8 A0A8C0MHT8_CANLF Zinc finger and BTB domain containing 6 ZBTB6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] HSGDRPYKCHCCDMDFKHKS;NEEENSDKDCEI 2 7.5 0.98738 -0.22538 0 0 7.21897 0 0 9.92178 0 10.5129 0 0 0 0 0 0 0 A0A8C0MHV4 A0A8C0MHV4_CANLF CCHC-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of gene expression [GO:0010629] cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270] DQSKRWLSDE;IDVDADFHARV;LENTYTGSG;LENTYTGSGD;VTNFIMKA;VYGSPSSPSPLRPTGTFAQ;WLSDELAGN;YTEREVSTKEDKPM 8 4.9 1.0019 -1.4726 0 0 10.7916 9.29845 11.0205 9.54185 0 10.1635 12.254 9.98542 11.697 8.76122 12.3335 10.3151 0 A0A8C0MHX3 A0A8C0MHX3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271] neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] signaling receptor binding [GO:0005102] EAKNSIVGKPAQHM;EVATISCQVNKSDDSVIQL;LTREGDAFE;PDIYPKEAKEKL;RPFPDIYPKE 5 12 1.0028 -0.83969 0 0 6.12984 0 0 0 0 0 8.02431 0 0 0 0 0 8.85287 A0A8C0MHY9 A0A8C0MHY9_CANLF UBX domain-containing protein FAF1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] NF-kappaB binding [GO:0051059]; ubiquitin binding [GO:0043130] GWKTGDVEDST;LNQNFMLIITHRE;LSTFPRRDVTQLDPN;NFITWAWDL;NSYFTVLTKMVFLKGKFQL 5 9.9 0.95347 0.049438 3.84599 0 0 0 3.11932 0 0 0 0 0 4.13241 0 0 0 0 A0A8C0MHZ3 A0A8C0MHZ3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] AAPLPLGASLVP;DLRDPQFSATPVL;ERDRLVQELAEAQA;ESRLQEAQKQ;FPLLPNLLQT;ISPPTNFNHL;LFVIHLHRNDIFQVGE;LQVSSDHWELE;RRGWQRVFAALSDSRLL;SSDHWELERLRKEVQTL;VAALRMQLEAAHS;VPLKKVRPLNPEGSLFL;VRLFALAKL 13 10.2 1.0023 -1.8429 0 12.283 0 0 0 11.2524 11.3592 12.5338 8.41924 0 0 5.7026 0 8.98297 12.697 A0A8C0MHZ4 A0A8C0MHZ4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CDC42BPA Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] CHITCVNKAPTAC;DWWSLGVCMY;EEGLFVVH;FLNTWNGV;GGMDQGSDAPARDYDGEDSDS;LTTLYENVSMRN;NVSMRNQQL;SFMTLRNPRPQES;SLGVCMYEML;SVAHWEAQITEIIQWVSDE 10 6.2 1.0034 -2.2773 0 0 8.45323 7.87817 7.69349 0 0 0 9.86665 0 12.5186 8.86056 6.65306 0 0 A0A8C0MHZ9 A0A8C0MHZ9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALLVALLIAALYLLRIRQKKAKG;ARQKDQETLKPEDN;LLVALLIAALYLLRIRQKKAKG;NFTCKSHGFSPRNITL;VVGVVCALLVALLIAALYLLRIR 5 12.8 0.72861 0.24935 0 0 0 0 0 0 6.34131 5.99829 0 0 0 8.55746 0 9.98868 6.73159 A0A8C0MI12 A0A8C0MI12_CANLF Suppressor of cancer cell invasion SCAI Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] transcription corepressor activity [GO:0003714] AYKNFTNLFGQPL;EADPVMVLN;EDRPELVVKKL 3 7.3 1.0039 -0.83132 0 0 10.0403 0 0 0 0 0 0 9.00582 0 9.62363 0 0 0 A0A8C0MI15 A0A8C0MI15_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TVWRFLKQLKIDLPYDPAIE 5 4.9 0.95406 0.049371 0 0 0 0 0 0 0 0 0 8.94574 0 0 0 0 0 A0A8C0MI35 A0A8C0MI35_CANLF Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid stimulus [GO:0071230]; positive regulation of TOR signaling [GO:0032008] late endosome membrane [GO:0031902]; Ragulator complex [GO:0071986] KVVNDNAPEHTLQPG;YYDHYIQIFVFR 2 22.3 0.93761 0.10434 7.51223 0 0 0 0 0 0 10.3658 0 0 0 0 0 0 0 A0A8C0MI39 A0A8C0MI39_CANLF WD repeat domain 25 Canis lupus familiaris (Dog) (Canis familiaris) LVAYDDSESEAE;PSAGVSEFIQPYLDSQ 2 5.4 0.9558 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 6.25327 0 A0A8C0MI63 A0A8C0MI63_CANLF F-BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VHCNQLSLQCVKDDEVRLGAGG 1 4.1 0.9739 0.046862 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.20129 A0A8C0MI77 A0A8C0MI77_CANLF Sterol carrier protein 2 (EC 2.3.1.155) (EC 2.3.1.16) (EC 2.3.1.176) (Acetyl-CoA C-myristoyltransferase) (Non-specific lipid-transfer protein) (Propanoyl-CoA C-acyltransferase) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (SCP-chi) (Sterol carrier protein X) Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] mitochondrion [GO:0005739]; peroxisome [GO:0005777] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; lipid binding [GO:0008289]" EMVTDLPSSFEEKSVIKA;GAILLNSSQKTNPLDKHV;RCLRRTSSPTATWAAAE 3 8.6 0.99361 -0.14308 0 0 0 0 0 0 0 0 6.26604 0 0 0 0 6.92624 0 A0A8C0MI79 A0A8C0MI79_CANLF Ras-associating domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ALQAQAQELEELNRELRQCNLQ;SEHTTCQE 2 8.7 0.9848 -0.25747 0 0 0 0 0 0 0 9.69134 0 0 0 0 0 0 0 A0A8C0MI96 A0A8C0MI96_CANLF ACB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fatty-acyl-CoA binding [GO:0000062] SRREPLEESL;TFLRRVTGW 2 7.5 0.99763 -0.10793 12.7156 0 0 0 0 0 0 0 0 0 12.8284 0 0 0 0 A0A8C0MIF5 A0A8C0MIF5_CANLF Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) ICMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] endoplasmic reticulum membrane [GO:0005789] protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671] GGGGGGGA;GGGGGGGG;KKKTKNKKRKLWLLSP;VKKKTKNKKRKLWLL 4 5.6 0.94027 0.10311 0 0 4.12598 0 0 0 0 6.26555 0 0 0 0 0 0 0 A0A8C0MII1 A0A8C0MII1_CANLF Cytochrome P450 family 2 subfamily W member 1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" DIGWLHHSTNASQ;DLDLTPDIGWLHHSTNASQ;PRIAVTVSSLF 3 6.4 0.99273 -0.55431 0 0 0 0 0 0 6.22807 0 0 0 0 0 0 0 0 A0A8C0MIJ0 A0A8C0MIJ0_CANLF Transmembrane protein 242 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ALPARPAPSPLP;TAPGAGVG 2 3.9 1.0022 -1.422 0 0 0 0 0 0 0 0 0 7.86084 0 0 0 0 0 A0A8C0MIJ2 A0A8C0MIJ2_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] GSGASEPRQQDEIENP 1 4.6 0.92375 0.11588 0 0 0 7.98385 7.98613 0 0 0 0 9.25439 9.2605 0 0 0 0 A0A8C0MIJ4 A0A8C0MIJ4_CANLF Transmembrane 9 superfamily member TM9SF2 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to membrane [GO:0072657] membrane [GO:0016020] ARYNQMDSTEDA;IKIYYHVVETG;LVLLLLLLRAAPG;RFCNPGFPIGCY;SPPRWPGLVLLLLLLR;VLLLLLLRAAPGP 6 9.3 0.99228 -0.5417 0 5.46699 9.89642 0 0 3.88411 0 0 11.1558 0 0 3.35882 0 0 0 A0A8C0MIJ5 A0A8C0MIJ5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HGTILFLYCVPD;IVHRNQENQSAEA;VSFIVHRNQENQSAE 3 9.2 0.98993 -0.20028 0 0 4.809 0 7.864 0 0 0 0 0 0 0 0 0 0 A0A8C0MIJ8 A0A8C0MIJ8_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVFRRRRKRL;LGSDGDCAANSPAAGGGG 2 8 0.99517 -0.56314 0 0 0 0 0 0 6.45462 0 0 0 0 0 9.36133 0 0 A0A8C0MIK3 A0A8C0MIK3_CANLF Alkylated DNA repair protein alkB homolog 8 (EC 2.1.1.229) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) ALKBH8 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" cytoplasm [GO:0005737]; membrane [GO:0016020]; post-mRNA release spliceosomal complex [GO:0071014] RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] AIGVKVYLCLPNF;AREESRDESLRDDSLKKEHLQ;CSGSCDAC;DENSEREDNQV;KKKKKKDKHSKKVKKEKKKKSKKQK;KKVKKEKKKKSKKQ;LLVMTGESRYLWT;QDTLSPFAGGG;QFPKHLIVAIGV;SNESTDSSSSSEDEWV;SVKTVSLSS 11 10.4 1.0036 -2.3847 0 6.55971 5.83322 8.82349 7.90406 7.76626 6.52146 9.9642 6.93782 0 6.96139 6.19785 0 9.0769 8.41032 A0A8C0MIK5 A0A8C0MIK5_CANLF [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) SMYD1 Canis lupus familiaris (Dog) (Canis familiaris) histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872] GYMKLYHP;LVTHGPSHPI 2 3.8 1.0023 -1.398 0 0 0 0 0 0 0 0 0 0 7.29655 0 0 0 0 A0A8C0MIP2 A0A8C0MIP2_CANLF Nitrite reductase MB (Pseudoperoxidase MB) Canis lupus familiaris (Dog) (Canis familiaris) extracellular exosome [GO:0070062]; sarcoplasm [GO:0016528] heme binding [GO:0020037]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] IPDPDGDDGDGD 1 5.9 0.94502 0.05044 0 0 6.58245 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MIP3 A0A8C0MIP3_CANLF Ras protein specific guanine nucleotide releasing factor 1 RASGRF1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AAWTSDISQCVDNIRCNG;DIKKIKKVQ;ESTEEDAKGSSQDIDHLDFKIG;GCCGGGGCGVEGTRS;HDPELLTQERK;IDHLDFKIGVEP;LTDLAFIE;NLREALKNCDPPCV;NSSEFPLFSYNNGV;PGCCGGGG;PPGCCGGGG;SLQILAHCKQNRD;VISLIDCTLLEEPE 13 10.8 0.99722 -3.6937 0 0 14.2186 7.54805 7.36693 0 5.97591 4.69844 12.7707 0 8.39094 8.07205 0 8.85708 7.33405 A0A8C0MIQ2 A0A8C0MIQ2_CANLF Armadillo repeat-containing domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDDIKFRAEAGDRA;IPPYKGPYFQTLA;LVAPFNKNE;PLGIRPLTKIPP;QEKPKPIPKPELTIK;VRDKVIRLILK 6 14.5 0.9852 0.035491 5.82421 0 0 0 0 0 0 0 8.50997 0 0 0 0 0 0 A0A8C0MIQ8 A0A8C0MIQ8_CANLF Centlein Canis lupus familiaris (Dog) (Canis familiaris) EQALESAQKKL;ITAQKSSSNIILLRERIVSL;KNITAQKSSSNIILLRE;LMIQKMNLQE;SIDSLKQRLSVAVK;TQKVLRNQEDVYT;VKEQLKQWEEGSGMT;VLRNQEDVYTAESISYQKLYNE 8 6.7 1.0031 -0.84093 7.62103 0 0 12.0669 12.743 0 0 0 0 0 11.6408 7.42828 0 9.63021 9.91652 A0A8C0MIR4 A0A8C0MIR4_CANLF NIPA magnesium transporter 1 NIPA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] DCSGGGGG;GAGPGSPR;GGGGGGGG;RSERSPHPPAGAGPGSPRPSPT;VFVGYLCIVLL;VGYLCIVLLMLLLLI 6 11.9 1.0036 -2.0462 0 0 0 0 0 0 8.49181 10.2597 10.279 0 2.52288 0 5.58853 0 0 A0A8C0MIR8 A0A8C0MIR8_CANLF C2H2-type domain-containing protein ZNF827 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] ANGRVESPVNVGSN;EGELSEGEHWY;EVLRDSLQCQDHLSPGVSSLCE;LLLPVPKG;MSTSPYECLQTC;NAADRPANHTKL;NSASEEESG;PQSLELLLLPVPKG;PSNSASEEE;SWKFNDQLFP 10 9.7 0.94386 0.05044 0 0 0 0 0 0 0 0 0 6.37034 0 0 0 0 0 A0A8C0MIT8 A0A8C0MIT8_CANLF Mab-21 like 3 Canis lupus familiaris (Dog) (Canis familiaris) EDGGCRRKCLQ;FLKHYFVRKSN 2 9.8 0.99193 -0.20797 0 8.57728 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MIU0 A0A8C0MIU0_CANLF TAFII55 protein conserved region domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase II promoter [GO:0006367] transcription factor TFIID complex [GO:0005669] DDDDDDDDNDEDEDDDDD;DDDDDEDE;DDDDDEDEDEEDEEK;DDDDDNDEDEDDDDDE;DDDDDNDEDEDDDDDEDED;DDDDDNDEDEDDDDDEDEDE;DDDDNDEDEDDDDDEDED;DDDEDEDEEDEEKDNYGDEYEVEEE;DDDNDEDEDDDDDEDEDEE;DDNDEDEDDDDDEDE;DEDDDDDEDEDEEDEEKDN;DEEDEEKDNYGDEYEVEEEEEDYYE;DSSSNSDDDDDDDDDDND;EDEDDDDDEDEDEE;EDEDEEDEEKDNYGDEYEVE;EDEEDEEKDNYGDEYE;EDEEKDNYGDEYEVEEEEEDYYEKD;EEDEEKDNYGDEYEVEE;EEDEEKDNYGDEYEVEEEEEDY;EKDNYGDEYEVEEEEED;ITPPLKNVRKKRFRKTTKKLIDFKQ;MSSDSSSNSDDDDDDDDDDND;NSDDDDDDDDDD;NSDDDDDDDDDDNDEDED;SDDDDDDD;SDDDDDDDD;SDDDDDDDDDDND;SDDDDDDDDDDNDEDE;SDDDDDDDDDDNDEDED;SDDDDDDDDDDNDEDEDD;SNSDDDDDDDDDDNDED;SNSDDDDDDDDDDNDEDE;SNSDDDDDDDDDDNDEDED;SSDSSSNSDDDDDDDDDDNDED;SSNSDDDDDDDDDDND;SSSNSDDDDDDDDDDNDE;VRKKRFRKTTKKLIDFKQIE 37 18 0.48171 0.48437 8.26003 9.46246 6.81468 8.69676 7.59731 9.28838 10.424 10.2905 8.56331 0 7.47703 4.32876 9.08911 8.81356 9.1692 A0A8C0MIU7 A0A8C0MIU7_CANLF Aldehyde dehydrogenase domain-containing protein ALDH8A1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" GEVYCRVPNSG;IFEDANLEECIPTTVKSSF 2 6.9 0.98756 -0.46124 0 0 0 11.088 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MIV1 A0A8C0MIV1_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALLTCCCCCCCCC;ALLTCCCCCCCCCFC;ALLTCCCCCCCCCFCCG;CALLTCCCCCCCCCF;CALLTCCCCCCCCCFC;CCCCCCCCCFCCG;CCCCCCCCCFCCGTL;CCCCCCCCCFCCGTLKPP;CCCCCCCCCFCCGTLKPPSE;CCCCCCCCCFCCGTLKPPSEE;CCCCCCCCF;CCCCCCCCFCCG;CCCCCCCCFCCGT;CCCCCCCCFCCGTL;CCCCCCCCFCCGTLKPPSEE;CCCCCCCFCCGTL;CCCCCCFCC;CCCCCCFCCGT;CCCCCFCC;CCCCCFCCG;LCALLTCCCCCCCCCFCC;LCALLTCCCCCCCCCFCCG;LLCALLTCCCCCCCCCF;LLTCCCCCCCCC;LLTCCCCCCCCCFC;LTCCCCCCC;LTCCCCCCCCCFC;LTCCCCCCCCCFCC;LTCCCCCCCCCFCCGTLKPP;TCCCCCCCC;TCCCCCCCCCF;TCCCCCCCCCFC;TCCCCCCCCCFCC;TCCCCCCCCCFCCG;TCCCCCCCCCFCCGT;TCCCCCCCCCFCCGTL 36 17 0.99704 -3.9655 6.55267 6.65249 7.72948 6.94521 5.76842 9.06641 10.801 7.81999 7.2364 8.87735 7.40369 7.07927 8.72253 10.5375 7.09687 A0A8C0MIV8 A0A8C0MIV8_CANLF Monocarboxylate transporter 2 (Solute carrier family 16 member 7) SLC16A7 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] monocarboxylic acid transmembrane transporter activity [GO:0008028] GAPLHPPPD;GVIANSRLIRPRI;QRFSSAVGLVTVVEC 3 7.8 1.0018 -0.66278 0 0 0 0 0 0 11.5871 0 0 0 0 0 8.16732 4.70636 0 A0A8C0MIX6 A0A8C0MIX6_CANLF Tripartite motif containing 37 TRIM37 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] membrane [GO:0016020] zinc ion binding [GO:0008270] DIDEETMSGENDV;FIKLALLLLLLLL;FIKLALLLLLLLLLLL;FIKLALLLLLLLLLLLLL;GAAHGALLQRFIKLALLLLLLLLLL;IKLALLLLLLLLLL;KDRSSMENLWGLQ;KLALLLLLLLLLL;KLALLLLLLLLLLL;KLALLLLLLLLLLLLLL;KLALLLLLLLLLLLLLLL;LALLLLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLL;LLLLLLLLLLLLLL;LLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLLC;LLLLLLLLLLLLLLLLLLLL;MSSDSDIECDTENEEQEEHT;QRFIKLALLLLLLLLLLLL;RFIKLALLLLLLLLLL;TQKSRDLSPPDNHL;VTTPVPPDFTSELVPSY;VVRGYYLSVFLEL 31 13 0.54167 0.42348 12.2869 12.5967 12.8114 9.69103 9.70527 10.9505 12.2053 12.3169 12.3491 12.634 12.5418 11.6723 12.7263 12.2614 12.8198 A0A8C0MIY8 A0A8C0MIY8_CANLF Heteroous nuclear ribonucleoprotein H1 HNRNPH1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; RNA binding [GO:0003723] AYEHRYVELFLNST;DVEFATHE;FKSNNVEMDWVLKHTG;QLSGGYGGGYGGQSSMS 4 11.7 1.0032 -1.5928 0 0 8.37247 0 0 0 0 0 0 0 4.1551 0 0 0 11.2319 A0A8C0MJ03 A0A8C0MJ03_CANLF 5'-nucleotidase domain containing 2 NT5DC2 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] GKQLFLITN;SQGGAARESGEWLLPP 2 4.8 1.0026 -0.98602 0 0 0 0 0 0 4.30655 4.12458 0 0 0 0 0 8.40178 0 A0A8C0MJ04 A0A8C0MJ04_CANLF Dopey N-terminal domain-containing protein DOP1A Canis lupus familiaris (Dog) (Canis familiaris) Golgi to endosome transport [GO:0006895] cytosol [GO:0005829] AFIPEASDDSGLEVRRQ;AKLLRKRAKK;ELGPVILEDVLI;IDQYQKYL;KEVLKQPPAIA;KPFSSKARQKIE;LAKLLRKRAKK;NFEYSSEWAD;NQVLQRHDIAR;PGAKPKVKL;RSHSSIQFSF;SEGQRTAAIPIGS;SLLILLKDSIQL;VLEPLLLLLLH 14 6.4 0.99676 -4.2568 0 0 0 0 0 5.59771 11.622 14.0861 10.2916 4.22612 5.15656 10.97 8.59496 5.91889 0 A0A8C0MJ08 A0A8C0MJ08_CANLF Glutamate receptor GRIA2 Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; postsynaptic density membrane [GO:0098839] AMPA glutamate receptor activity [GO:0004971]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] FSFLDPLAYEIWM;NINNDKKDETYRSL 2 3.6 0.93623 0.065056 0 0 0 7.22786 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MJ46 A0A8C0MJ46_CANLF Nucleolar protein 56 (Nucleolar protein 5A) NOP56 Canis lupus familiaris (Dog) (Canis familiaris) box C/D methylation guide snoRNP complex [GO:0031428]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] AEMARKLEKQEKKRLKKEKKRLA;GVIAEILRGVRLHFHNLVK;KKKLQKLSQ;KKRLKKEKKR;LRLLLETHLPSKKKKV 5 12 1.0023 -1.2708 0 0 0 0 0 3.69198 0 0 5.74795 0 4.51172 0 0 6.16096 0 A0A8C0MJ86 A0A8C0MJ86_CANLF Ribonuclease 4 RNASE4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676] AGISELVMAPPRTRALLLLLL;PELPVHFD 2 7.4 0.98606 -0.45175 0 0 0 0 0 0 0 0 0 0 0 4.33956 0 0 0 A0A8C0MJA3 A0A8C0MJA3_CANLF Alkylated DNA repair protein alkB homolog 8 (EC 2.1.1.229) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) ALKBH8 Canis lupus familiaris (Dog) (Canis familiaris) gene expression [GO:0010467]; methylation [GO:0032259] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA methyltransferase activity [GO:0008175] CSGSCDAC;LLVMTGESRYLWT;VGSRDSECCVSSVTD 3 5.4 0.98311 -0.2557 0 0 0 0 10.9441 0 0 0 0 0 0 0 0 0 0 A0A8C0MJB1 A0A8C0MJB1_CANLF MABP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; viral budding [GO:0046755]; virus maturation [GO:0019075] ESCRT I complex [GO:0000813]; late endosome [GO:0005770] HSNLYAISG;PLFSEFEEDSPGA 2 7.5 0.98834 -0.26098 0 4.60573 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MJB3 A0A8C0MJB3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AELWEGPLKAELQ 1 3.4 0.94035 0.059821 0 0 8.20814 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MJB5 A0A8C0MJB5_CANLF Nucleolar protein 6 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] RNA binding [GO:0003723] LQAACHRLKLWP;PTPPPPLPFIV;TVVCHLEGSGQWP 3 3.1 0.98753 -0.40421 0 0 0 0 10.4995 0 11.2127 0 0 0 0 0 0 0 0 A0A8C0MJE1 A0A8C0MJE1_CANLF Leucine-rich repeat flightless-interacting protein 2 LRRFIP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] LRR domain binding [GO:0030275] GAITVVSQEAAQVLESA;LSNIAREAEARLAA;PDTSLSEL;RRDSVVSTADYFSRSN;SEVEEKYK 5 8.5 1.0019 -1.2049 5.41227 0 0 0 8.29581 0 9.29188 0 12.5707 0 0 0 0 7.11707 0 A0A8C0MJG5 A0A8C0MJG5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;LARSAPSLLPPELVV;SGRGTGVATSLQEEALGC 3 6.2 0.98746 -0.46632 0 0 0 0 0 0 10.8586 0 0 0 0 0 0 0 0 A0A8C0MJH2 A0A8C0MJH2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SLGTGQGCGRCPCQGAG 1 4.4 0.9765 0.046227 0 0 0 0 0 0 0 0 0 0 0 10.8405 0 0 0 A0A8C0MJH3 A0A8C0MJH3_CANLF Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein AOPEP Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] DVAAVPGIETFT;EADFRCVGICGHMEYPCR;HKWIRVNRRPHKRKRRE;HKYTKAYKDVERFLQEDQAM;QFDYYAHCSQA;SAKPTQLREGRASWHYYVTM;SLGMARPNK;TYQLSQQDAEVRHRW 8 16.9 1.0021 -1.1355 0 0 8.89373 4.30429 0 9.36142 7.79025 0 0 7.61508 7.39652 0 0 5.2578 0 A0A8C0MJK2 A0A8C0MJK2_CANLF Carbohydrate sulfotransferase (EC 2.8.2.-) CHST12 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] PEQPSVPASSR;PREYVHNSSTHLTFNKFWRRYG;VPASSRPGLSNAEESVRGYD 3 11.2 0.99112 -0.18177 0 0 0 0 0 0 0 10.622 0 0 0 0 0 7.766 0 A0A8C0MJL2 A0A8C0MJL2_CANLF ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) DHX29 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of translational initiation [GO:0045948] cytoplasm [GO:0005737] "ATP binding [GO:0005524]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; translation initiation factor activity [GO:0003743]" IVEETGFVLEKDSEYCQ;KHKAPGAA;RRISAVSLATRV;SATVDSEKFSTYF;SEDPEESWENL 5 4.7 1.0033 -1.5213 9.65071 9.40765 9.61126 0 0 0 0 7.85487 0 0 7.8913 9.59528 9.17859 9.57756 0 A0A8C0MJN6 A0A8C0MJN6_CANLF Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) SIGMAR1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; postsynaptic density membrane [GO:0098839]; vesicle [GO:0031982] GLVRQQLWSGD;GVSSHLPWPS;RRWAWAALLLAAAAVLAQVVWL 3 11.6 1.0025 -1.164 0 0 0 0 0 0 0 0 9.45461 0 0 0 0 0 0 A0A8C0MJN8 A0A8C0MJN8_CANLF Fucose kinase FCSK Canis lupus familiaris (Dog) (Canis familiaris) "ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" HVLEARQDLSLR;VGSPSTLNRMEQ 2 2.2 0.99203 -0.20683 0 0 0 0 0 7.29728 0 0 0 0 0 0 10.6598 0 0 A0A8C0MJP5 A0A8C0MJP5_CANLF Cyclin dependent kinase like 4 CDKL4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GAGAPQAPEAAGP;LPARGVPEAAP 2 5.4 0.92276 0.095258 9.65578 0 0 0 0 0 0 0 0 0 0 6.92208 0 0 0 A0A8C0MJQ1 A0A8C0MJQ1_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CHLSPLQMTPGELALASG;LVAASYAFGGANSAIQTGN;YGTVVFTY 3 12.2 1.0024 -1.0003 0 0 0 0 0 0 7.23467 0 0 10.1882 0 10.1659 0 0 0 A0A8C0MJQ3 A0A8C0MJQ3_CANLF Nuclear receptor subfamily 6 group A member 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] VIERLIYLYHKFHQLK;YTHQPNRFPDLMMCLPEIRYIAGK 2 9.1 0.98439 -0.23953 0 0 0 0 0 5.03007 0 10.5396 0 0 0 0 0 0 0 A0A8C0MJQ5 A0A8C0MJQ5_CANLF Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] ESEELDEDMEF;PTVASVPHSTI;PVAAATTAAPAA 3 14.1 0.98739 -0.46782 0 0 0 0 0 0 0 12.3936 0 0 0 0 0 0 8.15684 A0A8C0MJR3 A0A8C0MJR3_CANLF ORM1-like protein 2 Canis lupus familiaris (Dog) (Canis familiaris) cellular lipid metabolic process [GO:0044255]; regulation of ceramide biosynthetic process [GO:2000303] endoplasmic reticulum membrane [GO:0005789] QIDFGLQFTSSRKFLSISPIVLY 1 19.5 0.97891 0.04627 0 0 0 0 0 0 0 0 0 8.19972 0 0 0 0 0 A0A8C0MJR5 A0A8C0MJR5_CANLF "5-aminolevulinate synthase, non-specific, mitochondrial (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)" ALAS1 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte development [GO:0048821]; hemoglobin biosynthetic process [GO:0042541]; protoporphyrinogen IX biosynthetic process [GO:0006782] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170] EASRRQGQRVGVI;SLIDTVRSYAAG 2 3.6 0.99173 -0.18331 9.5636 9.0786 0 0 0 0 0 10.4749 0 0 0 0 11.6163 0 0 A0A8C0MJR7 A0A8C0MJR7_CANLF "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (Keratin-8) (Type-II keratin Kb8)" Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363] structural constituent of skin epidermis [GO:0030280] DANAKVLAELEAALQRAKQDM;KFCKVSTSSPQ 2 7.1 0.98992 -0.21544 0 0 0 0 0 0 11.5091 0 0 0 0 0 0 0 0 A0A8C0MJT6 A0A8C0MJT6_CANLF Ig-like domain-containing protein MYPN Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] EPGKDYFNFL;GAPSPKVEWYREGT;LDCIVVGI 3 6.3 0.98969 -0.2633 0 9.6561 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MJU0 A0A8C0MJU0_CANLF R-spondin 4 RSPO4 Canis lupus familiaris (Dog) (Canis familiaris) nail development [GO:0035878]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] heparin binding [GO:0008201] KKGRRDRRPRKDRKLDRTLDVRPRP;PSTRECQEECE;SCFSQDFCIQCKRR 3 21.4 0.9929 -0.16798 0 0 0 0 0 0 10.3414 0 6.36217 0 0 0 0 0 0 A0A8C0MJU2 A0A8C0MJU2_CANLF Rho GTPase activating protein 33 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091] EDRSWWRGK;ELDFSPPRYPTPSW;ERLVRVHDVIQ;HRCIFDRRFSCLPEL;VPQVLRCCS 5 7.8 0.94164 0.061082 0 0 0 0 0 0 0 3.77093 0 0 0 0 0 0 0 A0A8C0MJW3 A0A8C0MJW3_CANLF Fork-head domain-containing protein FOXP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLQRQGLLTIQP;VEFQKRRPQKISGNPSLIKN 2 5.3 0.99027 -0.21056 0 0 0 7.30332 0 0 0 0 13.9357 0 0 0 0 0 0 A0A8C0MJX5 A0A8C0MJX5_CANLF Interferon related developmental regulator 1 IFRD1 LSMEM1 Canis lupus familiaris (Dog) (Canis familiaris) ESDFFYEDMESL 1 2.8 0.95478 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.51802 A0A8C0MJX7 A0A8C0MJX7_CANLF 5-phosphohydroxy-L-lysine phospho-lyase Canis lupus familiaris (Dog) (Canis familiaris) pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GGAERGLAAEHARGLSAQSPR 1 4 0.9495 0.049792 0 0 0 0 0 0 6.67002 0 0 0 0 0 0 0 0 A0A8C0MK10 A0A8C0MK10_CANLF Ran-binding protein 9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; plasma membrane [GO:0005886] ALAAGSSA;DVDMETEHYSNGV;NGSSKHDHEMEDCD;NGSSKHDHEMEDCDTEME;PGGGAGGG;PIPAACGIYYFEVK;YCATAEAFARSTD 7 10.5 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 13.2806 0 0 0 0 A0A8C0MK11 A0A8C0MK11_CANLF Sm domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] GGPSQQVM;GTVAAAAAAATASIAGAPTQY;SGGGGGQCACSQGHPCAH 3 14.6 1.0017 -1.3189 0 0 0 0 7.90334 0 0 0 0 5.80514 9.68384 0 0 0 0 A0A8C0MK18 A0A8C0MK18_CANLF LARGE xylosyl- and glucuronyltransferase 1 LARGE1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] FGWNKVAHIM;IPAITWLYLFAGSFEDGKP;KLRVKNKHVE;LSLAQGRAPGPRRGNH;QMWRLTAERELM;QQPVVEKCETIHV;TLVAQLSMDRLQ;VLFHRRNPLHFHLI;VLMSRHNVAYH;VLRTQPFLSALP 10 16.2 1.0035 -1.6221 10.8466 9.40075 0 0 0 10.3224 4.29521 0 11.4854 0 11.4534 11.6127 0 10.5489 8.0649 A0A8C0MK29 A0A8C0MK29_CANLF Integrator complex subunit 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATLEALCMLAQSSP;DYFSDQDPCVR 2 5.6 0.99462 -0.01881 0 0 10.5047 0 9.40773 0 0 0 0 0 0 0 10.0991 0 0 A0A8C0MK32 A0A8C0MK32_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) LOC106560154 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] DVTLQKQCVPFHR;EVAQKKKIPQKKLKKQKLM;VAQKKKIPQKKLKK 3 17.4 0.99454 -0.15404 0 0 0 0 4.86191 0 8.32008 0 0 0 4.81578 0 0 0 0 A0A8C0MK35 A0A8C0MK35_CANLF Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (Oligosaccharyl transferase 48 kDa subunit) Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation via asparagine [GO:0018279] oligosaccharyltransferase complex [GO:0008250] VHGGGIAG 1 1.2 0.98621 -0.25976 0 0 0 11.6734 11.7394 0 0 0 0 11.7173 0 0 0 0 11.7426 A0A8C0MK37 A0A8C0MK37_CANLF Extracellular matrix protein 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular space [GO:0005615] FSHLTRQGETLNLL;GNPTLLEHSLQ;NPTLLEHSLQ 3 5.2 0.35172 0.5972 9.45117 10.314 10.1657 0 0 0 0 0 10.7177 10.3224 0 9.33248 9.39797 0 7.63227 A0A8C0MK73 A0A8C0MK73_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;IENLNRPITRGE;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 7 0.94486 0.05044 0 10.6239 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MK76 A0A8C0MK76_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PGSAPPHPRPGS 1 3.7 0.99111 -0.18173 0 0 0 0 0 0 13.9013 0 0 0 0 0 0 0 0 A0A8C0MK82 A0A8C0MK82_CANLF Ras-related GTP-binding protein Canis lupus familiaris (Dog) (Canis familiaris) cellular response to starvation [GO:0009267]; negative regulation of autophagy [GO:0010507] Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EADEVLLFERATFLVISH;PRSPEGELFPGASQ;VISHYQCKEQRDVHRF 3 6.2 0.98639 -0.38964 0 0 8.37895 8.82133 0 0 0 0 10.1046 0 0 0 0 0 0 A0A8C0MKB5 A0A8C0MKB5_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] HCTVMVEVEDT;KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK 8 7.2 0.6899 0.28591 0 0 0 0 0 0 0 0 11.4834 0 0 11.3254 0 0 0 A0A8C0MKC2 A0A8C0MKC2_CANLF Tubulin-specific chaperone E (Tubulin-folding cofactor E) TBCE Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GAPEDGELK;IQKVKGLLARLLRVPV;TLNKCEILPEE;VLNLSENKLSFPLASAL 4 11 0.98997 -0.30551 0 8.41092 0 0 0 0 0 0 0 8.4654 0 0 0 0 0 A0A8C0MKG2 A0A8C0MKG2_CANLF "SH3 domain containing GRB2 like 2, endophilin A1" SH3GL2 Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle uncoating [GO:0016191] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793] AMRELSEVKDSLDMEV;ENWYDNFSDSEDDLGGNTN;IDENWYDNFSDSEDD;LHVLKVYLKV;QNLHDKDLREIQHHL 5 17.5 0.98909 -0.50805 6.61169 6.44667 0 0 0 0 0 6.89905 0 0 0 0 0 0 0 A0A8C0MKG3 A0A8C0MKG3_CANLF Centrosomal protein 43 (FGFR1 oncogene partner) CEP43 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; microtubule anchoring [GO:0034453] cell projection [GO:0042995]; centriole [GO:0005814] AELRAAVFLALE;GAPSLKDSE;TSISSAEPK;WRSEPSKQAG 4 11.2 1.003 -2.1694 7.60837 0 5.97691 0 0 0 0 7.9407 0 0 0 0 0 10.1675 0 A0A8C0MKG8 A0A8C0MKG8_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 7 ADAMTS7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GDLWTVGTVAWE;GVGASIHRCGVAPSG;GVQPCLSWYI;VGSWSECSTTCGLGAV;YWQRTNELSEDEEEA;YYDYNFINFHED;YYDYNFINFHEDLS 7 5.3 0.99075 -0.53813 14.0555 3.48993 0 0 0 7.66356 4.15429 0 0 0 0 5.37236 14.3023 0 0 A0A8C0MKH0 A0A8C0MKH0_CANLF BCLAF1 and THRAP3 family member 3 Canis lupus familiaris (Dog) (Canis familiaris) EDRKSSSQKG;IIHQVKGWY;PQRSAADSFRFEGKWHEDKLRH;QKRYPEDRAF 4 9.2 0.99197 -0.27195 0 0 0 0 0 0 0 0 0 12.5345 0 0 0 0 0 A0A8C0MKH3 A0A8C0MKH3_CANLF HECT and RLD domain containing E3 ubiquitin protein ligase 4 HERC4 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] DYKKPLKVIFV;DYPEDDVEETFCL;IVDLHFPLALYKKLLKKKPSL;LFKEVVVHLLKLYKIGIPPSERRI;LHFPLALYKKLLKKKPSL;NWFPYNGQCPPDID;VHLLKLYKI 7 8.8 1.0035 -1.1115 0 0 12.5514 4.57918 0 0 9.24522 0 0 10.0014 0 0 4.18412 8.71785 0 A0A8C0MKJ0 A0A8C0MKJ0_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) WWP1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin protein ligase activity [GO:0061630] GAMQQFNQ;KQIIWFWQFV;NSKQIIWFWQFV;TETLPSGWEQRKDPHG 4 4.3 0.99146 -0.51178 0 0 5.55906 0 3.60928 0 0 0 0 0 0 0 9.08481 0 0 A0A8C0MKJ1 A0A8C0MKJ1_CANLF Zinc finger and BTB domain containing 34 Canis lupus familiaris (Dog) (Canis familiaris) EQGDLLVRESQITE;TEVKVKME;VLSQLNELRL 3 6 1.0039 -1.0398 0 0 0 9.10428 0 0 0 0 0 0 8.39823 0 0 8.59242 5.64186 A0A8C0MKJ4 A0A8C0MKJ4_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) QSQYFANSVIVKDVRQ;SFHKLAKQ 2 6.2 1.0038 -1.0552 0 0 0 0 0 0 8.33669 0 0 0 0 0 0 0 10.997 A0A8C0MKJ9 A0A8C0MKJ9_CANLF Bestrophin Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254] DDDDFETNWCIDRN;PKRWSLPVSSQA;SATELPGDEWLWSFEKHGQRRSVI;TGAQKRYFE 4 9.2 1.0037 -0.81289 0 7.78437 15.992 0 8.47078 0 0 0 0 0 0 0 0 0 0 A0A8C0MKK3 A0A8C0MKK3_CANLF Glucagon like peptide 1 receptor Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] glucagon receptor activity [GO:0004967] DAVLKWMY 1 1.9 0.99096 -0.2154 0 13.7719 13.8948 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MKL9 A0A8C0MKL9_CANLF Plakophilin 3 PKP3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] GQAWLLQVGEGHSCVSAAQAGAHR;LLYFDGLRKLVFIKKKR;LRKLVFIKK;RRLRELPLT;VNIIAVLNNLVVA 5 8.5 0.97376 0.041303 0 0 0 0 8.77013 0 0 0 0 0 0 0 0 0 0 A0A8C0MKN6 A0A8C0MKN6_CANLF THO complex subunit 2 THOC2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397] THO complex [GO:0000347] CYDRVFSDIIYT;DESSTEETD;ESSAKLYINHTPPPLSKSKEREMDK;GVPKGAKG;LYLVSDTVLK;MCEPQTLCH;MYDLAVPHTSYEREVN;VEAKQIVRKLTMVVL;VRIGKSFMKEFQ 10 8.7 0.99723 -3.8914 13.095 0 0 0 0 3.82028 13.5042 9.18153 6.93887 0 0 6.39999 9.104 13.7215 5.60911 A0A8C0MKR8 A0A8C0MKR8_CANLF Cytoplasmic aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase) (Iron-responsive element-binding protein 1) Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] "4 iron, 4 sulfur cluster binding [GO:0051539]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]" ERNRERFEFLKWGSQAFRN;IDGLGVLGWGVGGIEA;KDTWPSRIM 3 4.6 0.98738 -0.32459 0 0 0 0 0 0 0 0 0 0 11.6077 0 0 9.44518 11.1089 A0A8C0MKT3 A0A8C0MKT3_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DRTYESSSHTLMA;PGWGLARLLRRV 2 5.5 0.91774 0.11026 0 0 0 5.49134 0 0 0 0 0 11.3785 0 0 0 0 0 A0A8C0MKT6 A0A8C0MKT6_CANLF DExH-box helicase 34 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676] AATSSAQD;DWNCPETRHLFEDAFFREEDYIRQG;LDQQLARQARR;LLGVLRRLLPKRPDLKVI;LRRLLPKRPDLKVI;SEECQKFWSFFE;WESTLDQQLARQA 7 7.1 1.0019 -1.2071 8.29108 0 7.14272 0 0 0 0 0 0 13.2237 0 0 0 4.19598 0 A0A8C0MKV4 A0A8C0MKV4_CANLF RNA binding protein fox-1 homolog RBFOX2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleus [GO:0005634] RNA binding [GO:0003723] AIPAYPGAD;YIPLIIPGFPYP 2 5.3 0.9869 -0.50054 0 0 0 0 0 0 9.15234 8.75632 0 0 0 0 0 0 0 A0A8C0MKY0 A0A8C0MKY0_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AEVSVRSTR;DQKIQETQIQE;EQNVHNIVMVTQCVEK;GVPETTQSLIQ;HPLPSYLE;LGVMWQTPA;LSESVLPEWTIREFRI;PEYHRGRSFITYKFIYQDMVYLETI;QECLSKNK;QYEIQLLFNDMKV;SEVVEGSTITMIDRP;SYTVSAFRQNQK;TSTSLHVWWTPSSGKVT;VDNYVVTLTHGNRV 14 8.1 0.99667 -4.2823 8.62695 10.2668 9.27466 8.69408 4.80823 3.85738 10.6793 0 10.1892 0 8.5619 7.17792 11.3273 11.1012 15.2189 A0A8C0ML23 A0A8C0ML23_CANLF Protein NDRG2 NDRG2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737] ELSGNSELIQKYRNIITHAP;LDQLADMIP;NRRDLNLERGGAV;PKPKRPAIL 4 15.5 1.0018 -1.8137 0 0 0 0 7.60095 0 0 0 0 9.91719 0 0 0 4.57483 0 A0A8C0ML33 A0A8C0ML33_CANLF Laminin subunit alpha 2 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] AEECYYDENVARRNLSLNIHGKYI;ARLIERCECPA;CDCSHLGNNCDPKTGQCICPP;CDQCCPGFHQKPW;CQECECDP;CQNCQHHTAGDFC;DLRLEPFYWKLPEQ;GLDAKNPLGCSQC;GYYWSAPAPYL;PVSRREFMTVLASLKRVLIQ;QCECKPNVQGRRCDECKPRMWWD;QPSVPGGSCQPCQ;RRLVLKKKNQ 13 10.9 0.97942 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.92529 A0A8C0ML47 A0A8C0ML47_CANLF Signal transducing adaptor molecule 2 STAM2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] LPSATGAAAYTPLD;SIDPTDAKPDSQ;VRGGGGGG 3 5.5 0.99388 -0.17228 0 0 0 0 0 0 0 0 0 0 0 0 0 9.38357 12.9381 A0A8C0ML48 A0A8C0ML48_CANLF Small integral membrane protein 30 SMIM30 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVYARKRNG 1 15.3 1.0042 -0.80421 0 0 0 10.0688 0 0 0 0 0 0 0 0 0 0 0 A0A8C0ML55 A0A8C0ML55_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEDEADYYCQNFY;DEADYYCQNFYTGTSP;DSIGSKSVYWYQQKLG;YQQKLGQAPVL 4 23.5 0.98971 -0.52885 0 0 0 0 0 11.7455 0 0 0 0 7.35173 0 0 0 0 A0A8C0ML72 A0A8C0ML72_CANLF Proline rich acidic protein 1 Canis lupus familiaris (Dog) (Canis familiaris) AATWATWQGSEAQA;VGRAARPLPIL 2 8.1 0.98715 0.035491 0 0 0 0 0 0 0 5.14282 0 0 0 0 0 0 0 A0A8C0ML75 A0A8C0ML75_CANLF ARID domain-containing protein ARID1B Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] brahma complex [GO:0035060]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677] AAGGGGGG;CVDEEDEEDE;DEEDEEDEDEDEEDSGKPE;DEEDEEDEDEDEEDSGKPET;DLSGSIDDLPTG;EDEEDEDEDEEDS;ELLVEYFRKCL;GGGAAQPG;GGGGAASL;GGGGDGGG;GGGGGGGA;GGGGGGGG;GGGGGGSG;GPSQPCGA;LVLILGKLILL;NVGTSSSA;PGGGGGGG;PGQGPPSGQPPYGGHQP;QSPMPQERGN;QSQAAAAA;QVTGPPPQPPPIRREITFP;QYLPSQSQQRY;TECVDEEDEEDEDEDEEDSGKPET;VDEEDEEDEDEDEEDS;VGEAPAAA;YYNQQPQPPHLPPQAQ 26 10.4 0.99051 -0.2674 0 0 9.27942 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0ML80 A0A8C0ML80_CANLF Barrier-to-autointegration factor Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear envelope [GO:0005635] DNA binding [GO:0003677] MGQKPVGS 1 6.6 0.98495 -0.25777 0 0 9.88315 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MLA5 A0A8C0MLA5_CANLF Protein MENT Canis lupus familiaris (Dog) (Canis familiaris) PPPSFSLAPAPAPAPAPSPSP;SPALAFWRRVRIGLEDIW 2 11.3 0.98711 -0.23084 0 0 0 0 0 0 0 0 0 0 0 0 11.692 0 0 A0A8C0MLC8 A0A8C0MLC8_CANLF Nucleosome assembly protein 1 like 3 NAP1L3 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] DSGEESDSNSSSSSTSCSSSSGS;EENAESKDFL 2 7 0.99064 -0.26805 6.44789 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MLD2 A0A8C0MLD2_CANLF Meprin A subunit (EC 3.4.24.-) (Endopeptidase-2) MEP1A Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ETPCPAGV;GVIFLSFAIISILSQKL;LHALGFYHEQ;VIMTILDQEPDARNRMS 4 7.5 1.0039 -1.1034 0 8.24717 0 0 0 0 0 0 0 0 9.03703 6.43289 0 0 0 A0A8C0MLD6 A0A8C0MLD6_CANLF EF-hand domain-containing protein EFCAB6 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] calcium ion binding [GO:0005509] AKKKKKKKKKKKSP;AKKKKKKKKKKKSPW;EGELAEAKKKKKKKKKKKSPWDI;ELAEAKKKKKKKKKKKS;GELAEAKKKKKKKKKKK;IERTFCQELPKC;IVLDTFVYRLPRRIF;KKKKKKKK;KKKKKKKKKKK;KKKKKKKKKKKSPWDI;LAEAKKKKKKKKK 11 11.5 0.52663 0.46646 0 0 0 0 7.69516 0 0 5.47116 8.0983 6.20024 0 4.86602 7.52435 0 8.04636 A0A8C0MLD7 A0A8C0MLD7_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FEAFFKEET 1 2 0.98823 0.018892 0 0 0 0 0 0 0 9.4673 0 0 0 0 0 0 0 A0A8C0MLG7 A0A8C0MLG7_CANLF L-fucose mutarotase (EC 5.1.3.29) Canis lupus familiaris (Dog) (Canis familiaris) monosaccharide metabolic process [GO:0005996] isomerase activity [GO:0016853]; monosaccharide binding [GO:0048029] DAGEAGPV;TYQSILSGAGCGGALA 2 4.9 1.0031 -1.1215 0 0 0 0 0 0 0 0 0 0 0 8.94986 10.3461 3.50818 0 A0A8C0MLH5 A0A8C0MLH5_CANLF Neurogenic mastermind-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607] transcription coactivator activity [GO:0003713] APAAHGRPVAHLHD;GSGLASMAGDADLIDS;SAQAQNAQRALSSV;VGSQPPAVSVASTRSSAPY 4 6.3 0.99493 -0.084158 8.97891 0 0 10.7159 0 0 0 0 0 8.99166 9.12915 0 0 0 0 A0A8C0MLJ1 A0A8C0MLJ1_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] LVSLNSNSEREQ;SETVLSPTELQNLD;WNNPQKQGLNRYHDDTKLV 3 12.9 0.9406 0.10035 0 0 0 0 7.70805 0 0 9.4654 0 0 0 0 0 0 8.23496 A0A8C0MLL1 A0A8C0MLL1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MNEKGEITTNT;PILPKLFGKIE;VIKTVWYWHRNRHIDQ 3 5.2 0.97897 0.035491 0 0 0 0 0 0 0 0 0 0 0 8.00096 0 0 0 A0A8C0MLQ8 A0A8C0MLQ8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AKKKILLKLTT;GGGGGGGE;KAKKKILLKL 3 19.6 0.99675 -0.57597 0 0 0 0 4.27583 0 3.72541 0 0 0 0 0 0 0 0 A0A8C0MLR6 A0A8C0MLR6_CANLF Caldesmon 1 Canis lupus familiaris (Dog) (Canis familiaris) muscle contraction [GO:0006936] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; myosin binding [GO:0017022] AEREREKERERERERERERERERER;ERERERERERVAEQERK 2 5.2 0.98313 -0.25242 0 0 0 4.3422 0 0 0 10.4786 0 0 10.8481 0 0 0 10.0384 A0A8C0MLS6 A0A8C0MLS6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DPITLNCPTNSEMH;PFPLPLCSTWPWRSCSYE;SGPLPAPRPGP 3 16.6 0.99277 -0.15058 0 0 0 5.92664 9.7178 0 0 0 0 0 0 0 8.19022 7.88411 0 A0A8C0MLV3 A0A8C0MLV3_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; ERBB2 signaling pathway [GO:0038128] plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544]; receptor tyrosine kinase binding [GO:0030971] CYDYDNDGSH;TSDGNWLMVH;VGVGGADF;YDADKMFPAFGFGAQI 4 8.8 1.0033 -2.3252 0 0 0 0 0 0 0 0 0 0 0 7.63096 0 0 9.30449 A0A8C0MLV6 A0A8C0MLV6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KTREANFHGDQ 1 10.6 0.98165 0.035491 0 0 10.3474 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MLW3 A0A8C0MLW3_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VLKKASLKGRKLQTL 1 16.5 0.95152 0.053874 0 0 0 0 0 0 0 0 4.97416 0 0 0 0 0 0 A0A8C0MLW8 A0A8C0MLW8_CANLF Cystin 1 Canis lupus familiaris (Dog) (Canis familiaris) GAAPEGGTRPLA 1 7.4 0.95304 0.05044 0 0 0 0 5.66908 0 0 0 0 0 0 0 0 0 0 A0A8C0MLX3 A0A8C0MLX3_CANLF Fibulin-1 FBLN1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; peptidase activator activity [GO:0016504] EQCCHSQLEELHC;NYRRSADTLRQEKTDTV;TEDNDCKDINEC 3 6.4 0.84796 0.1563 4.76776 0 0 0 0 0 8.27431 0 0 0 0 0 0 0 6.69 A0A8C0MLX4 A0A8C0MLX4_CANLF Solute carrier family 19 member 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] vitamin transmembrane transporter activity [GO:0090482] ALEPEPGPDAERKPWRCLVFY;LHWATFPGLGRAPGGWKGL;VGALWRVG 3 7.6 0.98808 -0.49161 0 0 6.72083 0 4.07279 0 0 0 0 0 0 0 9.13656 0 0 A0A8C0MLX5 A0A8C0MLX5_CANLF Centrosomal protein 152 CEP152 Canis lupus familiaris (Dog) (Canis familiaris) AKLLETPISNKSQSKTPQSEMLT;ASKLATMAKLL;DDILRFENEIHV;DIEHGYIKH;DLGIKKVNWKKSK;ESQKQCANILHSGSV;EVELELKYCENIA;HRSEQLEMNWHEHQVLPKSQN;HYSDCSEDGTDEELHRSEQ;NEDEEYDKEDYER;QPDMLPKNFS;SKDPATDVTGRGDPGVLAVLP;TNSEWEKRNMAKISK;VYKCNPLME 14 11.6 1.0021 -0.99243 8.7097 8.96619 0 0 0 0 11.1999 11.4926 12.6302 11.3647 11.293 10.7796 7.80665 0 9.50019 A0A8C0MLY2 A0A8C0MLY2_CANLF Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) FTSJ1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181]; tRNA nucleoside ribose methylation [GO:0002128] cytoplasm [GO:0005737] tRNA (cytidine) methyltransferase activity [GO:0016427] DLCAAPGS 1 2.4 1.0043 -1.1044 0 0 0 11.2643 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MLY6 A0A8C0MLY6_CANLF Unconventional myosin-VI (Unconventional myosin-6) MYO6 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; myosin complex [GO:0016459]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DEGFIIRHFAG;EKLHLSSPDHFRYLN;ESRDKFIRELFESS;FESSTNNNKDTKQK;LMQGGFPSRAS;LSSPDHFRYLNRGCT;LSVIKLKNKIKYRA;PNLKMTSHHFEGAQI;RNIRDDEGFIIRH;RQQRFFRIPF;SLSVIKLKNKIK 11 8.8 0.99647 -0.5827 7.94737 6.37321 11.248 0 6.2251 0 10.6943 12.5483 9.99379 0 3.98039 0 0 0 0 A0A8C0MLZ3 A0A8C0MLZ3_CANLF GTPase activating protein and VPS9 domains 1 GAPVD1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] QFTAAVEFI;SETWSTDVLGS;VSETWSTDVL;VSSRPSTPGLSVVSGIS 4 2.7 1.0031 -1.3836 0 9.52158 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MLZ7 A0A8C0MLZ7_CANLF RING-type domain-containing protein VPS8 Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to vacuole [GO:0006623] ETLQVLECY;LECYRLEETIQ;SLLAMASLTKILVIGLKPSL;WTCYKCSSSNKG 4 3.6 1.002 -1.2475 0 0 0 0 0 0 0 0 0 0 0 3.4994 9.34558 0 8.71929 A0A8C0MM11 A0A8C0MM11_CANLF Autophagy related 2A Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; phagophore assembly site membrane [GO:0034045] APFQKVLSSVSSSIDPE;GAEDLWLIE;IYPSEEGVTER;LDLADFQADVEL;PVLGYLPPTVITVLHT;SLVKMTLGGMTLTLLQTTAPS;TVITVLHTHL;VEHSSGDGE;VGLTSSVASALSELSLSDVDL;VTLNPQLSSAQWEVAPEKG 10 7.4 0.99151 0.0037108 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2151 0 A0A8C0MM24 A0A8C0MM24_CANLF MALT1 paracaspase Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] IYTSIVHKPPDVVMCDAYVT;PEGRGWRRLA;QGIYWCHVYN;VPVETTDD;VTEVTGRSSDGISESKLQ 5 8.3 1.0035 -2.2289 2.08549 0 7.7284 0 10.18 0 8.71905 0 0 0 0 0 9.92321 0 0 A0A8C0MM44 A0A8C0MM44_CANLF Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein AOPEP Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] EADFRCVGICGHMEYPCR;HKWIRVNRRPHKRKRRE;HKYTKAYKDVERFLQEDQAM;QFDYYAHCSQA;SAKPTQLREGRASWHYYVTM;TYQLSQQDAEVRHRW;VDVAAVPD 7 13.8 0.98485 -0.23937 0 0 0 0 0 0 11.0672 0 0 0 0 0 0 0 0 A0A8C0MM47 A0A8C0MM47_CANLF MICOS complex subunit MIC60 (Mitofilin) IMMT Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] EAKVVSQYHELVVQARDDFKRELDS;ELKYEFEQ;ITPEVLPGWKGMTDKLST;SVEKTIPYSDK;YSDKLFEMVLGSPP 5 10.7 1.0031 -1.333 0 0 8.70984 5.33735 0 6.87664 7.35288 9.33222 0 0 0 0 0 9.50892 9.76168 A0A8C0MM58 A0A8C0MM58_CANLF Fas associated factor 1 FAF1 Canis lupus familiaris (Dog) (Canis familiaris) GWKTGDVEDST;LNQNFMLIITHRE;LSTFPRRDVTQLDPN;LVAAINGVIPQENG;NFITWAWDL 5 9.6 1.0024 -0.75671 0 0 0 4.31354 0 0 0 0 0 6.88399 0 0 0 11.1932 6.53478 A0A8C0MM70 A0A8C0MM70_CANLF ADAM metallopeptidase domain 8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AGAECAQGACCREC;CWKGLCQQL;DNAQLITYVGGGGGARGGAWAQSGG;LEGGGEEVQ;YQELDFRVFLV 5 6.6 0.97402 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 9.16143 0 A0A8C0MM77 A0A8C0MM77_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) DTLRGGERRGKKKKKK;ERRGKKKKKKKK;KKKKKKAS;KKKKKKKASCQLQTRQR;KKKKKKKK;RGGERRGKKKKKKKK;RRGKKKKKKKKK 7 7.8 0.98539 0.046227 0 0 0 0 0 0 0 0 3.93687 0 0 0 0 0 0 A0A8C0MM85 A0A8C0MM85_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRK Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AEIQARRIAVDWESLGYNITRCH;AGILVFILLLLVVILIVKKS;AGILVFILLLLVVILIVKKSK;AGISAGILVFILLLLVVILIV;FILLLLVVILIVKK;FILLLLVVILIVKKSKLAK;GILVFILLLLVVILIVKKSK;GILVFILLLLVVILIVKKSKLA;ILLLLVVILIVKK;ILLLLVVILIVKKSKLAKK;ILVFILLLLVVILIVKKSKLA;ISAGILVFILLLLVVILIVKKSK;LDPNGVITQYEVSYSSI;LIVKKSKLAKKRK;LLLLVVILIVKKS;LLLLVVILIVKKSKL;LLLLVVILIVKKSKLA;LLLLVVILIVKKSKLAK;LLLLVVILIVKKSKLAKK;LLLVVILIVKKSKLA;LLLVVILIVKKSKLAKK;LLVVILIVKKSKLA;LLVVILIVKKSKLAKKRK;LLVVILIVKKSKLAKKRKDA;LVFILLLLVVILIVKKSK;LVFILLLLVVILIVKKSKLA;LVVILIVKKSKL;QVECMSCSMD;QVECMSCSMDC;SAGILVFILLLLVVILIVKKSK;SWTETHAVNAPTYKLWHL;TPKSSVNFRSL;TVSNLWNST;VECMSCSMDC;VECMSCSMDCDV;VFILLLLVVI;VFILLLLVVILIVKKSKLAK;VILIVKKSK;VINRIFRICNLTR;YHQDLYDDFEWVHVS;YHYFRGHNESK 41 10.9 1.0021 -0.99195 7.93611 8.08273 9.11549 8.6762 10.8996 5.89115 8.85848 12.4276 14.1527 9.09421 7.5938 6.97246 11.2708 8.34043 11.5851 A0A8C0MME6 A0A8C0MME6_CANLF Homeobox protein cut-like 1 CUX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DLSGSARRKGKDQ;FGHYVLGLSQGSVSE;GVWKDHWWSTV;IFSTGPYS;PWNKLTVRGKEPF;SLKKPPTA;YMYQEVDTIELT;YWKRFDLQQLQD 8 7.5 0.98393 -0.25344 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2033 A0A8C0MMF5 A0A8C0MMF5_CANLF "Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (28S ribosomal protein S18b, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LVSGDPWYPWYSWKQPPERELSRLR;TSHGAVSA 2 13.4 0.98671 -0.23038 0 0 0 0 0 0 8.25106 8.88448 0 0 0 0 0 0 0 A0A8C0MMG7 A0A8C0MMG7_CANLF NACHT domain-containing protein NOD1 Canis lupus familiaris (Dog) (Canis familiaris) ADALQKNTGITEICLNGNLIKPEEA;AELVGLKDESLG;ILTFLGLYSNQI;KVLYEELTKYKILTFL;LADALQKNTGITEI;LSKAKEKLLRHLVPPAALRRKRKAL;SSPGQRAWGGV 7 8 0.86564 0.17716 0 0 0 0 0 8.08661 11.7458 0 11.3166 6.23867 0 0 0 11.0522 0 A0A8C0MMG8 A0A8C0MMG8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VGVCWFLSFLNV 1 2.9 0.9882 -0.26453 0 0 0 0 0 0 0 9.19864 0 0 0 0 0 0 0 A0A8C0MMJ1 A0A8C0MMJ1_CANLF Amino acid permease/ SLC12A domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) L-arginine import across plasma membrane [GO:0097638] plasma membrane [GO:0005886] L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] DISSYWLG;LTEEDYIKAGLNDTSSLGPLG;LTSNIRRLFLVV;YILAGEVFGVIAGPAIVICF 4 17.8 0.99389 -0.020897 0 0 0 0 0 0 0 0 13.1833 12.5124 0 0 2.25752 9.95517 0 A0A8C0MMJ9 A0A8C0MMJ9_CANLF Synaptotagmin like 2 SYTL2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267] CQLNMEDLHQMPAEG;DITSPAWQ;ETWDWDNKQNK;GSKALLSTKVKLMPMES;IKDVGSSGKEEPEFHVYEKNRGKSE;KCTLQVLPDETV;LSEASSLAMHPSG;NSFVKCIILPDTSRKSRQKTR;PSGGKAHG;SERISFWEGE;SEVLTARPESI;STVPSQPDNP;VRETDIQPKSEFLELSAGLE 13 8.2 1.0006 -2.7931 0 10.7238 10.9252 0 0 8.73447 5.12342 9.60344 8.96887 0 0 8.36593 11.2818 5.23228 9.70344 A0A8C0MMK5 A0A8C0MMK5_CANLF Telomerase associated protein 1 TEP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGELLARYRQALETA;AKPESESSFLVAGADG;DEQKKFEDTYNA;DPAVFHMFLRQQV;EVKLWERPSMQLLG;FLGECRTWAPVLGSQVQ;IPEEETRRNRQLEVC;KLWERPSMQLLGLFQCEG;KSLVSGCDG;LYASSGPAEEQ;MSRNAKQDKTWT;NPNDVTLSGYSDGIL;PEPADQALKDKKLVLMS;PGAQPEEPAPTPEDNS;SEEKMPETELVE;TAHVLIAAQLWK;VLSLENRCLAMLPD 17 8.5 1.0028 -2.5503 0 0 0 10.1494 10.7791 0 0 10.5242 11.7802 0 9.44158 0 10.3353 0 6.82158 A0A8C0MMK8 A0A8C0MMK8_CANLF Rac/Cdc42 guanine nucleotide exchange factor 6 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] lamellipodium [GO:0030027] guanyl-nucleotide exchange factor activity [GO:0005085] DEVKELKQEN;EVCSFQQTLCQ;FLHKRKTERKP;LHKRKTERKPSEEEYV;LIIEETRSNGQTIIEEKSL;LNGRTGWFP;PHFKSMYLAYCANHPSAVNVLT;PSEEEYVI;SSSCSAHS;TRVEEGGW;TSSSSCSA;VEEGGWWEGT 12 17.8 0.99667 -4.2927 9.41918 0 7.52755 0 10.5632 0 0 9.02389 9.0717 8.86694 10.3292 0 11.7372 6.64645 8.20643 A0A8C0MML0 A0A8C0MML0_CANLF IRF tryptophan pentad repeat domain-containing protein IRF4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] FGSRGHHWQGPACENGCQVT;KRLCQSRIYWDGPL;MPPHERGWREYI;RIPWKHAGKQDYNREEDAAL;VVWERFQLAD;YKVYRIVPEGA 6 8.2 0.98917 -0.50803 10.8088 8.55382 8.8767 0 0 9.398 0 0 0 8.22564 12.6772 0 0 0 0 A0A8C0MMM0 A0A8C0MMM0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK36 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LSLLVLQLQDLP;RLAPKGNRSRILRL;VVVTDYAEGELFQILEDDGKL 3 3.7 0.99077 -0.13546 0 0 6.56952 0 0 0 0 0 0 0 0 0 0 7.75696 0 A0A8C0MMN0 A0A8C0MMN0_CANLF Hexosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] DALLREESRLY;GPADQLTLFPHWKSSHYD;HREDALLREESR;QCEAPGGGV;VLLCPCVL 5 10.5 1.0033 -1.5222 0 0 0 0 0 0 0 0 0 0 11.7825 7.71321 0 0 9.9969 A0A8C0MMS1 A0A8C0MMS1_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD1 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKAVDALVKKLKKKKG;FQQPNSHPFPHSPSSSY;VDALVKKLKKKKGA;VQAVAYEEPKHW 4 11 0.93294 0.096667 0 0 11.0389 0 0 0 0 0 0 0 0 0 0 0 6.70473 A0A8C0MMW8 A0A8C0MMW8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HEVHAVGSTHAALHVEKVVHQGE;VGSTHAAL;VGSTHAALHVEKVVHQGEP 3 4.4 1.0028 -1.0082 0 0 0 0 9.32809 6.45554 9.95973 0 0 0 9.15507 0 0 0 0 A0A8C0MMZ5 A0A8C0MMZ5_CANLF SON DNA and RNA binding protein SON Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726]; regulation of RNA splicing [GO:0043484] RNA binding [GO:0003723] APEIGIQEI;ELPESSVASVMELPG;HDGNIDLESDSFLK;KKSKKHKKHKNKKKKKKK;KKSKKHKKHKNKKKKKKKE;LPESSVASVMELPGP;MSMAADSYTDSYTDT;MTVSELPAVAVPQPPTG;PTKKSKKHKKHKNKKKKKKKEKEKK;PVPTTTVVLKS;SATPLPELPGPLSTP;SENGTNIEL;SKKHKKHKNKKKKKKKEK;SKKHKKHKNKKKKKKKEKEKKY;VIVNKPHVSDEEEEEPPFYHHPFKL 15 6.8 1.0019 -1.2481 0 0 0 0 0 9.32942 4.73194 10.6899 10.7116 9.92861 0 9.75789 4.93395 12.4294 6.1457 A0A8C0MN00 A0A8C0MN00_CANLF Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (Soluble guanylate cyclase small subunit) GUCY1B1 Canis lupus familiaris (Dog) (Canis familiaris) cGMP-mediated signaling [GO:0019934]; response to oxygen levels [GO:0070482] "guanylate cyclase complex, soluble [GO:0008074]" GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] CSKHASGEG;DLVVTQCGNA;ELRHKRPVPAKRYD;NPFVYKVETVGDKY;QESRISPYTF;QVWFLSRKNTGTEETT;SILFLCSPSVMNL 7 14.5 1.0016 -1.4103 0 0 6.75756 0 0 0 0 0 0 0 0 0 0 0 11.5567 A0A8C0MN03 A0A8C0MN03_CANLF Nephrocystin-3 Canis lupus familiaris (Dog) (Canis familiaris) convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; kidney development [GO:0001822]; Wnt signaling pathway [GO:0016055] DEQEQMETFQQASNSAHELGFEKYY;IDQVSNLN;LLEDCEEAFLKNP;SSLIIKRLTLKL 4 4.6 1.0014 -0.69799 0 0 0 0 0 0 0 8.93537 11.3036 0 0 0 4.02326 0 0 A0A8C0MN09 A0A8C0MN09_CANLF WH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin monomer binding [GO:0003785] IVPPRSEMRCYDRGVSLS;KDTSLHSAL;LEELDEELAERD;PALSEAEETVSVSSCFASEDT;PLQNILPVICAKC;RGHSGACSLRKVSSFASEE 6 6.5 1.0035 -0.87654 9.40009 0 0 0 0 0 9.35927 0 0 0 0 0 8.96423 11.617 0 A0A8C0MN47 A0A8C0MN47_CANLF Cylicin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of cytoskeleton [GO:0005200] ESTDAEYD;RSRPSESQITVPRHEKR 2 4.1 1.0036 -1.0582 0 0 0 6.76182 0 4.98591 0 0 0 0 0 0 0 0 0 A0A8C0MN52 A0A8C0MN52_CANLF DOMON domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] IDEVVENTT;IHDLEITDFL;NEMCLIFLFYYPRNNI 3 5.9 1.004 -1.0749 0 0 9.86456 0 0 0 0 0 0 0 12.1936 0 0 0 9.96665 A0A8C0MN58 A0A8C0MN58_CANLF Zinc finger DBF-type containing 2 ZDBF2 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AVTEAKLQKVHIGLVDK;DESYESSDSEINYDCDALLQSTDD;DLEGECCDSYDSEIG;DPESMSCEPCSSGM;ECCDSYDSE;FHCYFDDDCE;GDFDVSYDSDVPVHFV;HCYFDDDCE;KGSEEEDSTGKRSLLQKDKKSKK;KKSKKKVKI;NGPSVSEISLKSDISYHLMADHP;QPQEAGSKAGLF;RKTQTQRRLTTP;RSRDVSIEYKYK;SGKGKLLK;SLANQSKETFKV;VKTGEPSDSELMCESDVPLEIV;VLSDCDDNA;VRPSVIQK 19 9.6 0.99662 -4.2255 9.11437 8.97106 0 10.3709 9.42943 0 10.0591 11.6563 8.07446 0 8.66807 0 5.97829 9.87776 13.1444 A0A8C0MN60 A0A8C0MN60_CANLF WH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin monomer binding [GO:0003785] IVPPRSEMRCYDRGVSLS;KDTSLHSAL;LEELDEELAERD;PALSEAEETVSVSSCFASEDT;PLQNILPVICAKC;VHLPGWLGLHPALSGTR 6 5.7 0.98395 -0.25521 0 0 0 13.1411 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MN75 A0A8C0MN75_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVVMIQTPLSL;VGVYYCMQSTH 2 21.6 0.64378 0.34129 8.62183 9.38055 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MN76 A0A8C0MN76_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] membrane [GO:0016020]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] DTPPWFFFSFFFFLLLLFCF;LSLFLFFSSFFFS;SETVLSPTELQNLD 3 13.5 0.99398 -0.18867 8.52011 0 0 0 9.88722 0 0 0 0 0 0 0 0 0 0 A0A8C0MN83 A0A8C0MN83_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] chromosome [GO:0005694]; nucleus [GO:0005634] NAD+ ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779] ALGQCNEL;EVALGQCNELL;RFPAPASRLRAQR;SGGDERAPWRRGGGGRA 4 5.1 1.0028 -1.3468 0 0 2.15095 0 0 9.67087 0 0 10.9244 0 0 0 0 2.4347 9.37762 A0A8C0MN89 A0A8C0MN89_CANLF Lebercilin domain-containing protein LCA5 Canis lupus familiaris (Dog) (Canis familiaris) CSSDFGTT;DLESKLPSPERT;DLVTKRVLSARLLKIN;FAKTSGKS;FRTKFSLQKLKKISEARH;LDVQRNNI;PGRHRLKH;RVLSARLLK 8 11.9 0.99714 -3.9175 0 9.60314 3.70099 0 13.1775 6.96947 0 0 8.46361 0 8.32247 13.8247 0 0 0 A0A8C0MNA5 A0A8C0MNA5_CANLF Citrate transporter-like domain-containing protein OCA2 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] SGGGSRVQAG;SNQELRKMGLDFAGF 2 2.8 0.9835 -0.25261 0 0 0 0 3.80962 3.96708 0 8.8801 0 0 0 0 0 0 0 A0A8C0MNB1 A0A8C0MNB1_CANLF Zinc finger and BTB domain containing 24 ZBTB24 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AASSEYFSMMFAEE;ADTFGVLLEFIYTGCLQ;RRHCILHTGKKPF 3 6.6 0.99606 -0.099903 0 8.51869 0 10.2052 0 0 10.2766 0 0 0 0 0 0 0 0 A0A8C0MNC0 A0A8C0MNC0_CANLF VWFC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAHRILRK;FVVSPCERC 2 2.9 1.0033 -1.1044 0 7.20701 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MNC1 A0A8C0MNC1_CANLF Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4) LOC102154486 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin-ubiquitin ligase activity [GO:0034450] FEQKFNYRRPMYPIL;HVLHFITIFTGSI;ISMLNYFLQHL;LVTENLVLTEYTLYLGF;RRFADDILETSADSL;TSEIKSLFVH;VDRSTIARHL;YRESIKDLADYASKNLEAMNPP 8 11.2 1.0025 -0.72385 14.1395 0 0 7.9663 10.4305 0 6.95431 9.27212 13.5652 0 0 0 6.62232 0 7.16932 A0A8C0MNC7 A0A8C0MNC7_CANLF BMP and activin membrane-bound inhibitor homolog Canis lupus familiaris (Dog) (Canis familiaris) transforming growth factor beta receptor signaling pathway [GO:0007179] membrane [GO:0016020] frizzled binding [GO:0005109] SENKRLQDQRQQMLSRLH;VLACFGATPQRSHGPG 2 6 0.96203 0.049233 0 0 9.07537 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MND4 A0A8C0MND4_CANLF Uroplakin-1b (Uroplakin Ib) UPK1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MFVGICLFCLSV 1 4.6 0.94628 0.05044 0 0 0 0 0 0 0 8.4096 0 0 0 0 0 0 0 A0A8C0MND8 A0A8C0MND8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLPLDGFSHH 1 2.1 0.99927 -0.61146 7.26903 0 0 0 0 0 0 0 0 0 0 0 0 0 9.47919 A0A8C0MNE8 A0A8C0MNE8_CANLF Phosphatase and actin regulator PHACTR1 Canis lupus familiaris (Dog) (Canis familiaris) cell motility [GO:0048870]; stress fiber assembly [GO:0043149] nucleus [GO:0005634]; synapse [GO:0045202] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] GKEIKHICSNCSRGEDARDAEEVE;LKQPPALPP;PSAKPVLLL;PVLLLPPKKP;TSADGELSISNE;VPCSTSYHSSGLHSSDGV 6 11.7 0.97269 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 5.20191 0 A0A8C0MNH5 A0A8C0MNH5_CANLF "Glomulin, FKBP associated protein" GLMN Canis lupus familiaris (Dog) (Canis familiaris) EQIQTDDYGLCQCCKALIE;LVKVMTLCPI;PIETLRTHNKWFTGPQL;VGGEEIPNMPPEMQ 4 10.6 1.0024 -0.77186 9.20464 0 0 0 0 0 0 0 0 0 9.31465 0 9.49959 0 0 A0A8C0MNI2 A0A8C0MNI2_CANLF F-BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GMGSEGAPPM 1 2.4 0.9909 -0.27318 0 0 0 0 0 14.9551 0 0 0 0 0 0 0 0 0 A0A8C0MNJ6 A0A8C0MNJ6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959] SLHHAYAT 1 2.8 0.9889 -0.26125 0 10.8171 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MNK6 A0A8C0MNK6_CANLF Chordin CHRD Canis lupus familiaris (Dog) (Canis familiaris) pattern specification process [GO:0007389]; system development [GO:0048731] extracellular region [GO:0005576] AFEYPRDPEHRSYSDRGEPGSEDRA;ALVTPTHP;ALVTPTHPSGEVW;ALVTPTHPSGEVWGPLIRH;DTLPVPLAGALV;GHVAALPY;MTLETKPQRRNQRTVLC;PPSCPTPV;VGVCPGLGARGAHML 9 11.5 1.0027 -1.3888 11.502 0 11.8473 0 6.24304 0 0 10.6945 0 12.302 0 0 0 0 7.74692 A0A8C0MNL4 A0A8C0MNL4_CANLF protein-histidine N-methyltransferase (EC 2.1.1.85) SETD3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737] actin binding [GO:0003779]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; protein-lysine N-methyltransferase activity [GO:0016279] SSQTPGPNGSAVSPWWE 1 3.1 0.97948 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3071 0 A0A8C0MNL8 A0A8C0MNL8_CANLF CWF21 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CLCLSLHLSPQ;GPVDCDCPVAC;GPVDCDCPVACYRGHRG;KKKKKKGG 4 8.6 0.98919 -0.19891 0 0 10.5143 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MNM6 A0A8C0MNM6_CANLF Fibronectin type-III domain-containing protein IFNAR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGVMRTLFNCLCSRACF;TAPSWTVAIVLAASV 2 5 0.98982 -0.22357 0 0 0 0 0 10.707 0 0 0 0 0 0 0 0 0 A0A8C0MNN0 A0A8C0MNN0_CANLF Glutamate receptor GRIA4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of smooth muscle cell apoptotic process [GO:0034392] postsynaptic membrane [GO:0045211] AMPA glutamate receptor activity [GO:0004971]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507] FSFLDPLAYEIWM;GENGRVLTPDCP;PPNEFGIFNSLWFS;SGFWGLAMGAFP;SQYSRGVF;TGNVQFDHYGR;YEWHTEEPEDGKEGPSDQ 7 9.8 1.0041 -0.82204 6.63006 0 0 0 0 0 8.05691 0 0 7.20623 10.3288 0 0 0 0 A0A8C0MNN4 A0A8C0MNN4_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] PYDNNSPVLSERSLL;VLSERSLLAMQEDV;VLVSHLPSSKSR 3 4.9 0.98583 -0.42879 14.1346 0 0 8.17208 0 6.72069 0 0 0 0 0 0 0 0 0 A0A8C0MNQ2 A0A8C0MNQ2_CANLF BRCA1 associated ATM activator 1 BRAT1 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; DNA damage response [GO:0006974] AAGQLLVHI;AAGQLLVHIL;AAGQLLVHILG;CGLWETLAQTLN;LSCTGDQCP;TASSSGSL 6 4.5 1.0041 -0.80421 0 0 0 0 0 0 0 7.74584 0 0 0 0 0 0 0 A0A8C0MNQ6 A0A8C0MNQ6_CANLF Adenylyl cyclase-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179] LAGPVAEYLKVNKETG;RDVKVQVIGKVLTISINKT 2 9.6 0.72755 0.25877 0 0 0 0 0 10.6466 0 11.3982 0 8.46826 0 0 11.6242 11.7426 0 A0A8C0MNS4 A0A8C0MNS4_CANLF Purine rich element binding protein B PURB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LASKRLDIQNKRFYLD;LDIQNKRFYLDV 2 5.6 0.93276 0.099673 0 0 0 0 3.71578 0 0 0 0 0 0 0 5.84967 0 0 A0A8C0MNT0 A0A8C0MNT0_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] zinc ion binding [GO:0008270] APGAAAPQPGPAE;LVHFDNWDDSYDY;NWDDSYDYWCDVNSPYVQ;YDYWCDVNSPY 4 5.5 0.98642 -0.41162 0 0 8.99653 0 0 0 4.75189 0 10.4334 0 10.6519 0 0 0 9.76401 A0A8C0MNT9 A0A8C0MNT9_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EHLKEKLDDYIKLWNGLVKVFRNER;IAYDITSHYPLPPKN;IKRTPRKYLAEIVLIDD;RRRKMRLKIGFLLRSLLVLGS;RRRRKMRLKIGFLLRSLLVLGSFL;SRRRRKMRLKIGFLLRSLLV;VGHIYRLEGW 7 13.2 0.99149 0.0075479 0 6.10035 0 0 6.52867 9.09458 6.48949 0 0 0 0 0 10.6751 6.6978 0 A0A8C0MNU0 A0A8C0MNU0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] DAGVYYCMQGIQ;DIVMTQNPLSL;PGVPDRFSG;PGVPDRFSGSG;PGVPDRFSGSGSG;PGVPDRFSGSGSGTDF;VYYCMQGIQAPPTVVQP 7 44.3 0 8.2594 4.55213 0 0 7.14527 0 0 0 0 0 12.4499 12.617 12.6325 0 0 7.69105 A0A8C0MNW5 A0A8C0MNW5_CANLF Semaphorin 3D SEMA3D Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] semaphorin receptor binding [GO:0030215] DGNACSRY;FLGSSEGL;VCGTGAFHPICGYI;VFNGPYAHKESADHR 4 6.1 1.0019 -1.2515 0 0 0 0 0 0 5.01494 0 0 0 0 0 0 0 0 A0A8C0MNW9 A0A8C0MNW9_CANLF Bromodomain-containing protein 9 BRD9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GVQCALSLQEFVKD;RRRRKRNQRRRSTWT;SLQEFVKDAGSYSKKMVDDLLDQI;VGEQPEVTHDPYE 4 10.7 0.95085 0.053874 0 0 0 0 0 0 0 0 0 7.16017 0 0 0 0 0 A0A8C0MNX1 A0A8C0MNX1_CANLF "Myosin-9 (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain IIa)" MYH9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] cortical granule [GO:0060473]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] ALEEKRRLE;AQQAADKYLYVDKNF;GIPEEEQMGLLRVI;IRICRQGFPNRVV;LEKVTTEAKLKKLE;MQSTQRAYFYQRFP;RHEMPPHIYAITDTAYRSM;TKDFSALESQLQD;VGANIETYLLEK 9 6.2 0.94151 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.99559 A0A8C0MNX7 A0A8C0MNX7_CANLF Transcription factor 25 TUBB3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874]; RQC complex [GO:1990112] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] ALFFRSLLPNY;DIDRILERIEDSSGL;GKLRKKKKKQKNKKNTTGE;KLRKKKKKQK;KLRKKKKKQKNK;LVDLEPGTMDSV;SVVPSPKVSDTVVEPYN;VEWIPNNVKVAV;YEDDEEESEAQ 9 8.4 0 1.8106 0 9.99407 10.7977 7.23974 8.03963 7.1982 4.46081 0 6.14262 9.30287 9.55928 9.08847 8.7809 8.61908 9.66784 A0A8C0MNY0 A0A8C0MNY0_CANLF Ferric oxidoreductase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ACRGSTLKPENHGPNELHGTF;AVTSIPSVSDSLTWRE;FLYTLLREIIH;HFDEFDCPAE;WRWPVKIAAVI 5 13.5 0.98529 -0.44061 0 10.0213 0 5.74513 0 7.83453 0 9.31152 0 0 0 0 0 0 0 A0A8C0MP04 A0A8C0MP04_CANLF Transferrin-like domain-containing protein LOC477072 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] extracellular space [GO:0005615] metal ion binding [GO:0046872] AKDLKEEDF;DCSGKFCLFHSATKDLL;DKASCVSKMLLDQQLLFGRNG;DLLFKDSAEGF;FKDSAEGF;FPSVSVEEATAEMAQ;GQCGLVPV;HYDLLCLDNSRKSV;KTISWNNLQGRKSCHTAVDRTAGWN;LFKDSAEGF;NDCSGKFCLFHSATKDLL;NVPGKECVPNNHER 12 19.1 0.99339 -0.031389 0 0 0 0 0 6.75235 0 0 0 0 8.1532 0 0 7.95629 8.19638 A0A8C0MP06 A0A8C0MP06_CANLF LRRNT domain-containing protein EPYC Canis lupus familiaris (Dog) (Canis familiaris) PLPKNTAYFYSRFNRI 1 5.1 0.93559 0.067202 0 0 0 0 0 9.77632 0 0 0 0 0 0 0 0 0 A0A8C0MP09 A0A8C0MP09_CANLF Transferrin-like domain-containing protein LOC477072 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] extracellular space [GO:0005615] metal ion binding [GO:0046872] AKDLKEEDF;DLLFKDSAEGF;FKDSAEGF;FVKHSTVL;GQCGLVPV;KTISWNNLQGRKSCHTAVDRTAGWN;LFKDSAEGF;LNPYNLKPVVAEF;LYWKLPEPRESLQKAASSF;NVPGKECVPNNHER;RWNLCRTLNKHYYWCYLLKTSLF;SLQKAASSF;TVLENLPNKADLDQYEL;VFEAGLNPYNLKPVVAEF;VVKKSSTFNL;WNLCRTLNKHYYWCYL;YGKDKQTRYYAVA;YWKLPEPRESLQKAASSFFTA 18 23.1 0.9879 -0.22577 0 0 0 0 0 0 10.8285 0 0 0 0 8.38698 0 0 0 A0A8C0MP23 A0A8C0MP23_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] MMTHTGERPYLCQQ 1 2.1 0.93763 0.060955 8.50708 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MP26 A0A8C0MP26_CANLF Discs large MAGUK scaffold protein 2 DLG2 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] bicellular tight junction [GO:0005923]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] kinase binding [GO:0019900] IVRLYVRRRRPI;QGKCPAQNCSVEAPAWM;QKSCDQKI;QPSVTLQRAISLE;VIEEQSGP;VIPSKRRVER 6 6.7 1.0013 -2.6933 0 9.12846 9.39403 4.65128 8.39099 0 0 0 0 0 0 0 0 0 0 A0A8C0MP47 A0A8C0MP47_CANLF Guanine nucleotide-binding protein subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158] heterotrimeric G-protein complex [GO:0005834] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] EGRPDALRPP;GGGGGGGG;TLESMMACCLSDEVKESKRINAEIE 3 5.9 0.98608 -0.23222 0 0 0 0 0 10.0101 0 0 0 0 0 0 8.21344 0 0 A0A8C0MP53 A0A8C0MP53_CANLF Receptor expression-enhancing protein REEP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATAAVMAA;GVKWMMYWIIFA;YWIIFALFTTAETFTDIFLCWFPFY 3 22.4 0.95284 0.05044 0 0 0 0 0 0 0 0 0 7.64537 0 0 0 0 0 A0A8C0MP54 A0A8C0MP54_CANLF G protein-coupled receptor 143 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-tyrosine binding [GO:0072545] ALGCGGCP;GVPGHAGRPLSN 2 3.1 1.004 -1.0539 7.18517 7.27891 0 0 0 0 0 0 7.36212 8.92582 0 0 0 0 0 A0A8C0MP57 A0A8C0MP57_CANLF Ankyrin repeat domain 34C Canis lupus familiaris (Dog) (Canis familiaris) AAAEQLSSVSLEPSKGP;DDDTELRTD;GETALMVACITKHVDQQ;SISDITNSIDGKDP;SSARRRPPHLLE 5 13.1 1.0031 -0.88208 0 0 9.28591 0 0 0 0 0 0 0 0 0 0 8.68247 0 A0A8C0MP66 A0A8C0MP66_CANLF Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1) Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; RNA splicing [GO:0008380] membrane [GO:0016020]; nuclear speck [GO:0016607] PSHWCRWVCLLSAMPL;WSTGLPKIRRDPVVVVVVVI 2 7.2 0.93625 0.097439 0 0 5.35181 0 0 0 0 8.4065 0 0 0 0 0 0 0 A0A8C0MP70 A0A8C0MP70_CANLF Macro domain-containing protein GDAP2 Canis lupus familiaris (Dog) (Canis familiaris) HIALRTVRRFLEIHGE 1 3.6 0.96313 0.049233 0 0 0 0 0 0 0 0 3.0625 0 0 0 0 0 0 A0A8C0MP73 A0A8C0MP73_CANLF ADAM metallopeptidase domain 23 FAM237A Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] ADEDNTSQ;GVCSNEATCICDFTWAGTDCSI;KTYKKYRSSH;LLLVLLLLPPLATSSRPRAWGA;LSLESNDQWPFLSELQ;LVLLLLPPLA;RIKQHADAVHLISHVTFHY;TEYCTGDSGQCPPNLHKQDGYACNQ;TGRPHIIQKSLAGQYSKQMK 9 17.6 0.95167 0.049531 4.62837 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MP80 A0A8C0MP80_CANLF Ribosomal protein S6 kinase A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DSPGLPASANAHQ;FEMLTGTLP;LVLLLLLLNKKTWILINLLYLLP;VQINGNAAQFAEV 4 9.7 0.97867 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 7.39051 0 A0A8C0MP82 A0A8C0MP82_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;TELYIQTHGTF 4 5.3 0.98156 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.67095 A0A8C0MPD2 A0A8C0MPD2_CANLF protein-arginine deiminase (EC 3.5.3.15) PADI4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668] PLWHQRAPAALLL;VGRKKYPLGRILI;VSLLDTANPELPESLLFQD 3 4.9 0.98765 -0.4967 9.07205 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MPD7 A0A8C0MPD7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RTIPSHTLHI 1 11.4 0.99993 -0.61146 0 0 0 0 0 0 0 0 0 0 8.7738 0 0 0 0 A0A8C0MPE5 A0A8C0MPE5_CANLF Copine family member 9 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277] plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544] DEDPNCAGIDGVLESYFQS 1 3.4 0.95168 0.052773 0 0 0 0 0 0 0 0 0 0 0 8.43304 0 0 0 A0A8C0MPF8 A0A8C0MPF8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HLLPGSRPSW;LSSWETRAYRSGQWETR 2 6.6 0.99562 -0.56523 0 10.3314 0 0 7.32085 0 0 0 0 0 0 0 0 0 0 A0A8C0MPG0 A0A8C0MPG0_CANLF Exocyst complex component 2 EXOC2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] exocyst [GO:0000145] DADVDTTH;FVVKLTKLVL;IPECGVRQYGGWEVKSEL;QDLILDLRVRCVMVTLQHTAEE 4 6.5 1.0031 -1.9117 0 0 0 0 0 0 7.4025 0 0 4.38391 0 0 10.7969 0 0 A0A8C0MPJ3 A0A8C0MPJ3_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] KINSRERKRMQDLN;PGAHAGGGSRADPKEEQQQQLRR;PGGGAGGG;PKEEQQQQL 4 16.2 1.0015 -0.69773 0 0 10.0369 0 0 9.9479 0 0 0 0 0 0 0 0 11.0386 A0A8C0MPK1 A0A8C0MPK1_CANLF Germ cell nuclear acidic peptidase GCNA Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; response to stress [GO:0006950] DPDQDQDRDQDQDRDQD;IDEDSCDQG 2 5.2 0.97691 0.046227 0 0 0 0 0 0 0 0 0 0 0 7.10014 0 0 0 A0A8C0MPL5 A0A8C0MPL5_CANLF "AlkB homolog 4, lysine demethylase" Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] membrane [GO:0016020] GVRFLHVFFFFFNFYLFMI;HVFFFFFNFYLFMIVTERERQRLRQ 2 9.2 0.9472 0.085009 0 0 0 0 0 0 7.40591 0 7.5462 0 0 0 0 0 6.03265 A0A8C0MPM6 A0A8C0MPM6_CANLF NFKB inhibitor delta NFKBID Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DIREHKGKTP;VGMEDPLDTRLYAEPSL 2 4.6 0.9772 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 8.71727 0 A0A8C0MPN7 A0A8C0MPN7_CANLF SPIN-DOC-like zinc-finger domain-containing protein ZFTA Canis lupus familiaris (Dog) (Canis familiaris) AAASEEGGGEEEEEEEEEWWGEP;AECLMDYDPRGNRLVCM;EEEEEEEEEWWGEPAQGQ;LDRRLKESLQNWF;PEDDDDDEDG 5 11.5 0.99438 -0.1254 0 0 0 3.68358 0 0 0 3.81383 8.40109 5.6094 0 0 0 0 0 A0A8C0MPP0 A0A8C0MPP0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) DAPK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein serine/threonine kinase activity [GO:0004674] ALHVAARYGHADVVQ;EDIEREVS;FCCYDYFAANDPTS;LLIAAGCGNIQILQ;LNGVYYLHSLQ;TDVILILELVAGGE;VGDFSVWEFSGNPVYFC 7 7.1 0.98712 -0.45949 0 9.3786 9.86177 0 4.17273 0 10.1704 12.8111 0 0 0 0 0 9.37639 0 A0A8C0MPP4 A0A8C0MPP4_CANLF ABC transporter domain-containing protein ABCA14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CRMEMKQYGVQW;GVGYHIII;ILWFLLQKRK;IVCSSANIPAFVNCSKA;PAFVNCSKASEYLGLT;RHDSLPLKVRKFYLKLYMLALQS;RQLLVNIILWFLLQKRKVI;WDNILSPVNPHDS;YSISQITLEEVF 9 7.7 1.0042 -1.9832 15.0529 15.0946 0 0 8.23946 0 0 14.4829 0 0 14.5085 14.2753 0 9.09019 0 A0A8C0MPQ4 A0A8C0MPQ4_CANLF Malate dehydrogenase (EC 1.1.1.37) LOC119881628 Canis lupus familiaris (Dog) (Canis familiaris) malate metabolic process [GO:0006108]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] L-malate dehydrogenase activity [GO:0030060] GVVECSFVK;WCLLWRHSNKRGPV 2 6.4 0.98397 -0.25538 0 0 0 0 0 0 0 0 0 7.40701 0 0 0 0 0 A0A8C0MPQ8 A0A8C0MPQ8_CANLF Transferrin-like domain-containing protein LOC477072 Canis lupus familiaris (Dog) (Canis familiaris) antibacterial humoral response [GO:0019731]; iron ion transport [GO:0006826] early endosome [GO:0005769]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] metal ion binding [GO:0046872] AKDLKEEDF;DCSGKFCLFHSATKDLL;DKASCVSKMLLDQQLLFGRNG;DLLFKDSAEGF;FKDSAEGF;FVKHSTVL;KTISWNNLQGRKSCHTAVDRTAGWN;LFKDSAEGF;LNPYNLKPVVAEF;LYWKLPEPRESLQKAASSF;NDCSGKFCLFHSATKDLL;NVPGKECVPNNHER;SLQKAASSF;TVLENLPNKADLDQYEL;VFEAGLNPYNLKPVVAEF;VVKKSSTFNL;YGKDKQTRYYAVA;YVTALRNLREDVQTQGSTCSNTAEE;YWKLPEPRESLQKAASSFFTA 19 30.9 0.97439 0.035538 0 9.70389 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MPR2 A0A8C0MPR2_CANLF C2H2-type domain-containing protein JAZF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] GGGGGGGG;GVCGAPGL;LSSSVSRGNVSTPPR;PGGGGGGG 4 10.1 1.0033 -1.3349 0 0 0 0 0 0 0 0 0 0 10.4967 0 0 0 0 A0A8C0MPT5 A0A8C0MPT5_CANLF Junctional sarcoplasmic reticulum protein 1 JSRP1 Canis lupus familiaris (Dog) (Canis familiaris) EGSPAGGA 1 2.6 0.98928 -0.26225 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.70309 A0A8C0MPV3 A0A8C0MPV3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SSSRTQTNSK;STQHSPRIHFGP;TLISSGTQLSSEIQPTSE;TQTSSRIQP 4 5.2 1.0018 -0.96064 0 0 8.4463 0 8.94184 0 0 0 0 0 0 0 0 9.566 0 A0A8C0MPV5 A0A8C0MPV5_CANLF Caspase recruitment domain family member 11 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737] CARD domain binding [GO:0050700] ELLTFQERYYKMKEERDS;ERDQAFHSRDEAQTQ;LLRVLKDKISEEQRKTVWVDEDQ;PGNDSILRRYKEDAP;TKEEVHWTIQRCSGSVTLYYKVN;VHWTIQRCSGS 6 8.5 0.99722 -0.59828 0 4.20006 0 11.0116 0 0 9.71272 0 0 0 0 8.77604 0 0 0 A0A8C0MPX0 A0A8C0MPX0_CANLF CABIT domain-containing protein THEMIS Canis lupus familiaris (Dog) (Canis familiaris) DLSIEEDILA 1 1.9 0.98256 -0.24826 0 0 0 0 0 0 0 0 0 0 0 9.75308 0 0 0 A0A8C0MPY6 A0A8C0MPY6_CANLF FUN14 domain-containing protein 2 (Hepatitis C virus core-binding protein 6) FUNDC2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422] mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] EVKSKAEEVVSF;MTARRSASYRAE;VTGGFFGG 3 16.9 1.0011 -0.62682 0 3.51463 0 9.48563 0 9.3581 0 0 0 0 0 12.5303 0 0 0 A0A8C0MPY9 A0A8C0MPY9_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGSSAVPG;PADPARPPPR;VDVVVNPK 3 5 1.0031 -2.3477 0 0 0 0 12.4569 0 0 0 0 0 0 8.66281 12.4261 0 0 A0A8C0MQ12 A0A8C0MQ12_CANLF Gamma-tubulin complex component TUBGCP5 Canis lupus familiaris (Dog) (Canis familiaris) microtubule nucleation [GO:0007020] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] DFDWGKYLMEGEEIDL;DFYTSIFDKIREKETWQNVSFLNVQ;DTTKKKLPVHI;NVDTPNWSEESED;NWSEESEDEDDQ;VDKLSPRLAQLK 6 8.2 1.0027 -0.71882 0 0 0 0 0 0 0 11.399 9.49019 0 0 0 0 7.27156 0 A0A8C0MQ24 A0A8C0MQ24_CANLF Toll-like receptor 2 LOC491698 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; toll-like receptor signaling pathway [GO:0002224] membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670] transmembrane signaling receptor activity [GO:0004888] KDSLSSWQVGTFSTLSV;LEADLSLFGY;VLLSFTLILGLQPS;VYVLLEECRQ 4 12.5 0.98604 -0.41552 0 0 10.0369 0 9.78493 0 0 7.60355 0 0 0 0 0 5.68386 0 A0A8C0MQ53 A0A8C0MQ53_CANLF Endoplasmic reticulum oxidoreductase 1 beta ERO1B Canis lupus familiaris (Dog) (Canis familiaris) protein folding in endoplasmic reticulum [GO:0034975] endoplasmic reticulum membrane [GO:0005789] FAD binding [GO:0071949]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] GGGCGCRC;HCSIKDCHVEPCPES 2 4.2 1.0049 -1.1044 6.50806 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MQ54 A0A8C0MQ54_CANLF Exocyst complex component 3 like 1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] exocyst [GO:0000145] EAYACLRELEQLQEETWAPLGGLEL;EDPALLVAAVRIAEVDAGYTPS;GPEADVWAP;QPDGVASGALAPVEAAL 4 10.5 1.0019 -1.2128 0 5.71149 0 0 9.91991 0 11.7452 0 5.11624 0 0 4.69226 0 10.5201 0 A0A8C0MQ78 A0A8C0MQ78_CANLF tRNA wybutosine-synthesizing protein 2 homolog (EC 2.5.1.114) Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] FIGSTEEDDRRLG;TSAFGIEL;TSSLILTLNT;VGFGMPPLCSTWL;WFYYSTRYVYL 5 7.8 0.98555 -0.4427 9.37077 0 13.0288 0 0 0 0 0 0 9.12453 0 0 0 9.72901 8.52603 A0A8C0MQ83 A0A8C0MQ83_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) ACVR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] GNEDHCEGQQCFSSLSI;RYGEVWRGSWQ;VGKGRYGEVWRGSWQG 3 6.7 0.99473 -0.15686 0 0 0 9.27256 0 9.30802 0 7.29195 0 0 0 0 0 0 0 A0A8C0MQ95 A0A8C0MQ95_CANLF "Cofilin-1 (Cofilin, non-muscle isoform)" Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] actin cytoskeleton [GO:0015629]; lamellipodium membrane [GO:0031258]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015] VGTVGQNVDNPFATF 1 9 0.95156 0.053901 0 0 0 0 0 0 0 0 0 0 0 0 6.28057 0 0 A0A8C0MQ99 A0A8C0MQ99_CANLF Bromodomain and PHD finger containing 1 BRPF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AEELDEEVEYDMDEEDYIWLDIMNE;AKCRGYPS;ALVDEDAVCCICNDG;CHKANCYTAFHVTCAQQAGLYMK;DAAEEERLV;EYDMDEEDYIWLDI;FYRAAVRLREQG;GVSPIPQEIFEYLMDRL;IEYHLYHYDH;LERLDEVNASKQS;LSEVPDYLDHIK;LSHSEGEEDEDEEEDEG;LTPFLILLRKTL;MTQEAREH;VELIRKREKLKRETIKVQQIAMEMQ;VEYDMDEED 16 18.4 1.0034 -2.2555 9.46287 9.12267 7.38638 5.46437 5.25414 7.29103 8.97848 0 0 9.38407 2.94574 9.22567 10.3554 0 11.0394 A0A8C0MQA7 A0A8C0MQA7_CANLF F-box and leucine rich repeat protein 3 FBXL3 Canis lupus familiaris (Dog) (Canis familiaris) entrainment of circadian clock by photoperiod [GO:0043153]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytosol [GO:0005829]; nuclear body [GO:0016604]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin-protein transferase activity [GO:0004842] DSSKESAEAAC;VEFVKMCGGRL;WNQVFHMPDLWRCFEFELNQPATS 3 10.7 0.99426 -0.56187 0 8.53854 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MQD0 A0A8C0MQD0_CANLF Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (Cleft lip and palate transmembrane protein 1-like protein) CLPTM1L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ARGGCRVSGGRSGRQ 1 1.8 0.9882 -0.22696 0 0 8.80348 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MQE7 A0A8C0MQE7_CANLF CP-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; oxidoreductase activity [GO:0016491] ALGLKPHVLVL;GPAPPSGCWPLR;LGAAQRLRAH;PGAGARPALHLL;QDVWFKKL;YLLYTLNRHQ 6 5.6 1.0033 -1.5605 0 0 0 8.91516 0 0 0 9.93162 0 0 0 0 0 10.2159 9.98456 A0A8C0MQF5 A0A8C0MQF5_CANLF Rhodanese domain-containing protein POC1A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of MAPK cascade [GO:0043409] cytosol [GO:0005829] MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine/threonine phosphatase activity [GO:0008330] VPRGLSEPVCALHVPACT 1 4 0.97903 0.048313 0 0 0 0 0 8.48957 0 0 0 0 0 0 0 0 0 A0A8C0MQF6 A0A8C0MQF6_CANLF Aryl hydrocarbon receptor nuclear translocator 2 ARNT2 Canis lupus familiaris (Dog) (Canis familiaris) aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GQFQGRPSEVWSQWQSQHH;PAARQRPPGRRRRRRRRRRRRR;QGSKYCLVAIGR;RPPFPGQQIPSQ;RRRRRRRRRRRRRGRGGAAGAE 5 8.3 0.99235 -0.065531 7.74853 0 0 0 0 5.76025 0 10.1605 0 0 4.22234 0 8.81938 0 0 A0A8C0MQG3 A0A8C0MQG3_CANLF DNA helicase (EC 3.6.4.12) CHD6 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] ADYSLEVPGFGA;EEEEENEEENVGV;ESQKRKKKKT;GVAQMNIKN;GVAQMNIKNGKHL;GVKKKRKK;GVQQLSKMEVEDLL;IDQILQRRTHTITIQSE;KLVLIDKLLPKLIAGGHKVL;LQAMIQAAGKLVLIDKLLPKLIAGG;MDKEDNTEDKLDGLQ;QAMIQAAGKLVLIDKLL;SEPEASEHSFSSSAALVAQ;VKKKRKKK;VLHDDGYKKHLKQHCNKELEVP 15 6.4 0.99698 -3.6625 10.3341 0 0 0 0 0 10.4212 10.7005 10.4197 0 0 5.13988 7.76957 0 6.93605 A0A8C0MQH6 A0A8C0MQH6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PEFCIPPRLLPPCAP 1 4.7 0.98486 -0.24532 0 0 9.59154 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MQI1 A0A8C0MQI1_CANLF Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 LINGO1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154] GDMRLVPEPSG;RQSAQPGR;SFKRLYRLKVL;TQGSAPGP 4 4 1.0025 -1.3893 0 0 10.2341 0 0 0 0 0 0 0 0 12.7519 0 12.12 0 A0A8C0MQI5 A0A8C0MQI5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IKSKNLKHNVLQ 1 9.4 0.94528 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 3.86096 0 0 A0A8C0MQJ7 A0A8C0MQJ7_CANLF SH3 domain-containing protein CACNB4 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] EDVPVPSTAISF;QDTYKPHRN;YEEMFDVILDENQLE 3 9.9 0.98963 -0.26403 0 0 0 0 0 0 0 0 0 0 0 0 10.4754 0 0 A0A8C0MQJ8 A0A8C0MQJ8_CANLF Coiled-coil domain containing 148 CCDC148 Canis lupus familiaris (Dog) (Canis familiaris) DLQLEDISRNFQLSEE;KKKKIRKYWAKKE;LSDWNMKILDYSSEE;MAVQKNGILD 4 9.6 0.99195 -0.0067578 0 0 4.09685 0 9.05192 0 0 0 0 0 0 0 0 0 0 A0A8C0MQK8 A0A8C0MQK8_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone binding [GO:0042393] DEEDEDEEEYDEDA;DEEDEDEEEYDEDAQ;DEEGYNDGEVDDEEDEEDVGEE;EDEEDEEEEEEGEEEDVSGEE;EDEEEYDEDAQVV;EDEGERNISP;GLDDDEEDEDEEEYDED;VEDEEDEEEEEEGEEEDVSGE 8 23.9 0.98422 -0.25697 4.93621 0 0 3.51614 6.07286 0 6.15259 3.94186 0 0 0 9.00152 7.82043 0 9.09693 A0A8C0MQL2 A0A8C0MQL2_CANLF Ankyrin repeat domain containing 50 ANKRD50 Canis lupus familiaris (Dog) (Canis familiaris) IEHGAIVDHT;KILFHYSFAEWLLD;LLENKSNID;VEHLLDHG 4 2.9 1.0006 -2.7693 9.44989 0 0 0 0 8.59835 0 9.30115 0 0 0 0 0 8.5479 0 A0A8C0MQL7 A0A8C0MQL7_CANLF Telomerase associated protein 1 TEP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGELLARYRQALETA;AKPESESSFLVAGADG;DEQKKFEDTYNA;DPAVFHMFLRQQV;IPEEETRRNRQLEVC;KSLVSGCDG;LYASSGPAEEQ;MSRNAKQDKTWT;NPNDVTLSGYSDGIL;PEPADQALKDKKLVLMS;PGAQPEEPAPTPEDNS;RTAGVLQAQAQAQLDRVVLFG;SEEKMPETELVE;TAHVLIAAQLWK;VCVSRRREAEGAAQ;VLSLENRCLAMLPD 16 8.6 0.94912 0.050089 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6176 A0A8C0MQM6 A0A8C0MQM6_CANLF "Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)" FBP2 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094] anchoring junction [GO:0070161]; nucleus [GO:0005634]; Z disc [GO:0030018] "fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; metal ion binding [GO:0046872]" EDKTSEDEPS;GVDLFMLDPALGEF;PLILGSPDDVQ;TPKEKRGK 4 11.6 1.0023 -1.8622 0 0 11.2948 7.55934 7.26688 0 0 0 0 0 9.38744 0 0 0 0 A0A8C0MQP2 A0A8C0MQP2_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HUWE1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein polyubiquitination [GO:0000209] Golgi membrane [GO:0000139]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630] AASTTVTT;CLCQACSAQDCNF;DDEGEEGDEDDDDDGSEMELD;DDQEDDEGEEGDEDDDDDGSEM;DEEEEEEEDEEDDQEDD;DEGEEGDEDDDDDGSEM;DEGEEGDEDDDDDGSEME;DERKYPYH;DLIIEFDNMFSS;EDDQEDDEGEEG;EEEEEEDEEDDQEDDEGEEGDED;EEEHTQEED;EEEHTQEEDSSGS;EEGDEDDDDDGSEMELDE;EEGLEDAANV;EGEEGDEDDDDDGSE;ESPEEVAC;GHNALFETFN;LSEQLSLDELWDMLGE;LVVTQKAA;NLPIDFPTSAA;QSSDFDTQSGFSIN;RQRRSHHAA;SNEDEDDSQDEEEEEEEDEEDDQ;SQDEEEEEEEDEEDDQEDD;TEKLLRLLSLISIALPENK;TPLVTLLLRH;VHLERTPKLS;VIRRSSLLTEKLLRLLSLISI;YHWVDLLDRFDGIL;YSSATAKTQHN 31 5.7 0.99697 -6.1875 5.94923 6.99152 0 6.14883 4.9726 7.01212 10.4734 10.9241 11.7174 7.99797 12.9374 6.55873 10.4962 11.2322 4.2187 A0A8C0MQQ0 A0A8C0MQQ0_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein ADGRV1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DEYEVSISYVIITGNS;DGNGSIYYGVKIQTN;DLCFIPNIYAALF;DLMDELLSVSG;EEDFEEQTLTLK;FFPMENQKIESSPG;FGLISVTWLWGGLHM;FIVNITDVYLV;GGSPGPGG;HLLDDNVPEEKEVYQV;HYLYLCQFSWMLIQSVNFWYVL;IADPVSGSF;KENVKETYVKV;LDDGIIEFYL;LDSCPYLSILALHW;LIREKGTYGMVTVT;LLGSGYDFTIQ;LSIENRNLFYEI;LVTAMLVSGR;NDDPNGIFSLE;NLPIIRNSGTLGNVTVQWVATINGQ;NMPFSVTVSEP;PVSGYLEFRQGETNKSFIISARDD;PYFVITHEERS;QVLKSGYT;RFKALRISAML;SAMLDTEPEMDEHFVCTL;SIVQSFLDA;VTLSLDRVNV;YFAEPRVVRVQEGE;YIVREPVQGLFGTVTVQF 31 6.5 0.99706 -6.4634 12.0216 0 13.2316 0 9.85734 10.1703 13.44 12.4305 12.0479 9.3323 13.6108 11.7789 0 11.5415 12.2772 A0A8C0MQQ8 A0A8C0MQQ8_CANLF Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) PTPN13 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] protein tyrosine phosphatase activity [GO:0004725] ADHEVPQSQPIKLGD;ATDYSDRGDSDMDEATYSSSQDH;DFELEVELLITLI;DLEFDISDLVRCMRLQRHGMVQ;DPALLTPLHSPA;EEEQKEQPQ;ESNVQEDDIYDDP;LLLGRVLELPRMPVL;PSPLPPNTTLGQS;QSQRPSRQYETPL;TLHSSGNPSSQVPL;TQGMTLEEAKRALDMSL;VKALTKIP;VRLLLGRVLELPRM;YFKDISSDNNSGHEDSENASS;YQPLQNNAKEKSDKTSWEEKPRG 16 9.4 0.99956 -2.8802 10.3865 0 0 0 0 0 7.90857 8.2465 5.35811 0 10.701 0 10.6795 9.55921 3.33557 A0A8C0MQR4 A0A8C0MQR4_CANLF Junctional cadherin 5 associated JCAD Canis lupus familiaris (Dog) (Canis familiaris) cell-cell junction [GO:0005911] GGGGGGGA;GGGGGGGG;MKKAVWEEEL;TISLESWHQP;VCAGPRQQ;VGRTEFQKQDLG 6 3.6 1.0026 -1.3859 0 0 0 0 0 0 8.69519 11.4009 0 0 0 0 0 0 13.0749 A0A8C0MQR9 A0A8C0MQR9_CANLF F-actin monooxygenase Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytoskeleton [GO:0005856] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] EKQWHLDQELRGYLNQEGALKTPAD;GLASSAFA;QEELLRWCR 3 4.1 1.0021 -1.8731 0 0 7.02647 0 0 0 9.76045 0 0 0 0 0 0 0 9.10915 A0A8C0MQS1 A0A8C0MQS1_CANLF G-protein coupled receptors family 3 profile domain-containing protein GPR156 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] G protein-coupled receptor heterodimeric complex [GO:0038039] G protein-coupled GABA receptor activity [GO:0004965] DFSDHLNLGCSQKPRPEQS;LAASAHSLAARGP;PSEGPSDPQ;TESSSSDELFCRCHRP 4 7.3 1.0045 -1.0465 0 13.0732 0 0 0 0 5.63006 13.1656 0 12.8909 0 12.7523 0 6.50751 0 A0A8C0MQS8 A0A8C0MQS8_CANLF Contactin-associated protein-like 3 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604] calcium ion binding [GO:0005509] EVTVRSPTPFNDD;FLRFLPLAWNPKGRIGMRIEVYG;PDSSSGPG;QYHCNCDAD;VGMSQEVSGNPRR 5 5 1.0033 -2.0652 9.54295 14.2136 0 0 0 0 4.84765 0 0 9.0805 0 0 0 0 0 A0A8C0MQU1 A0A8C0MQU1_CANLF RanBD1 domain-containing protein NUP50 Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] AGGKPLEGLSNGSSI;ESETNKMPLATQS;PCTRTGKNNVLIVCVPNPPIDEKN;SSGLTSSA 4 13.9 0.97391 0.041303 0 0 0 0 0 0 8.88798 0 0 0 0 0 0 0 0 A0A8C0MQU6 A0A8C0MQU6_CANLF AXH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] ESGRLQQAMQAK;FVTTALPKSENF;HRSYALSPHTV;RKRRWSAPETRKLEKSEDEP 4 6.9 0.86345 0.18509 0 0 0 0 9.57645 0 0 10.3427 0 0 3.51589 0 0 0 0 A0A8C0MQW6 A0A8C0MQW6_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] membrane [GO:0016020] cysteine-type deubiquitinase activity [GO:0004843] AGRQYYLGDKCQVRLESGG;DPASVPHGAVYYPMMSD;GTAYGGSSQIHGAM;HYPQTAGSIMSNEHFHP;LDPEIYRNVE;LESGGRYYNAH;QLHVENYPVYAEPP;RYYNAHIQE;VGNENNSVTVFIE;VTPVPAWN;VYVPQMQQQQLHVENYP 11 13.6 1.0028 -2.1187 8.49233 9.02804 8.33293 7.37981 0 6.53831 0 0 13.2991 3.33042 0 9.94694 14.6874 0 7.92416 A0A8C0MQX2 A0A8C0MQX2_CANLF KIAA0930 KIAA0930 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AARMAQKMSFGFYKYNNMEFVR;RRRRRRRAQRR;YFMEKWAPRQDDMLFYVRRK 3 8.7 0.9848 0.035491 0 0 3.67683 0 0 0 5.79095 0 0 0 0 0 0 0 0 A0A8C0MR12 A0A8C0MR12_CANLF Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DYKVFFPNYRNDL;GSPAPQSNQVPVSLP;HAFAMTCIW;LSQESHEQCIQW;NYMDPICDFLYHMKY;PYLPIYFGN 6 5.5 0.99278 -0.14018 0 0 0 0 0 0 0 0 0 11.202 0 0 0 0 0 A0A8C0MR20 A0A8C0MR20_CANLF Anosmin 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] AASGGCLA;CPPFPPWIWAPAHSE;CVESCEADNECSG;LVWCQNHKQ;SKSLVPTKKKRRKTTD;TELQSGQLEIKWSSKFNIS 6 8.9 0.98762 -0.36898 0 0 6.00589 8.67649 0 7.14262 2.92077 0 0 9.27237 0 0 0 0 0 A0A8C0MR29 A0A8C0MR29_CANLF Agrin Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; receptor clustering [GO:0043113] basement membrane [GO:0005604]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; laminin binding [GO:0043236] AGPCEQAECGSGGSGSGED;DCEQMTGLCSCKPG;DTDLFVGGIPEDQASVVLERTSI;EEVEHCVE;GEDGECEQELCQQH;GHCQTCGDTV;GVTYGSTC;LADFHGFSYL;PCLGVRCPFGATCAV;SEVKKDFRSV;SEYSSPALA;TAARGVGLAGCPSEY;TCVRSADGQTATCLCPATCRGPP;VEGQELFYT;WNFRGIVTDGRSGCTP;YLNAVTESELTNEIPAE 16 10.3 0.9976 -3.3787 9.54861 9.25807 0 9.75811 9.74497 9.99053 10.5837 0 7.83719 0 7.42223 0 0 12.2178 10.176 A0A8C0MR38 A0A8C0MR38_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CQEEQEEEAEEEEEEEEEEEE;DLLPSQQQS;EEDEEDEEDEEDEEEQVLLSEEHPG;EEEEEEEEEEQEEQ;EEEEEEEEEEQEEQEEEQEEEQKE;EEEEEEQEEQEEEQ;EEQEEQEEEQEEEQ;LVHAYCPGLDRWLCLG;QEEEAEEEEEEEEEEE;QEHEEEQEQEEDEEDEEDEEDEE;QEQEEDEEDEEDEEDEEE;QEQEEDEEDEEDEEDEEEQ 12 10.9 0.99099 -0.0035883 6.6703 0 0 9.05026 0 6.08434 8.88923 0 0 0 0 6.43316 10.5093 7.91994 5.46663 A0A8C0MR56 A0A8C0MR56_CANLF Interleukin 6 cytokine family signal transducer IL6ST Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IFFTTESVGELLDP;METRALEIESLLTLCNKR;TASTRYSFTVQDLKPFTEYV;TDVSVVEI;TSPDISHFERSK;VGNLPRQQY 6 9.1 0.99103 -0.22151 0 0 0 0 0 0 0 0 0 5.45115 0 0 8.22289 0 0 A0A8C0MR64 A0A8C0MR64_CANLF Annexin A2 (Annexin-2) Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phospholipase inhibitor activity [GO:0004859] DIISDTSDDFCK;LSLEGDHFTPL;SYCPYDML;YGKYLYYYIQQDTKG 4 13.4 1.0032 -1.5765 0 0 0 8.47468 0 0 0 0 0 10.0589 7.65992 0 10.3941 0 0 A0A8C0MR71 A0A8C0MR71_CANLF NOT2/NOT3/NOT5 C-terminal domain-containing protein CNOT2 Canis lupus familiaris (Dog) (Canis familiaris) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036] CCR4-NOT core complex [GO:0030015]; P-body [GO:0000932] GIPSRTNSMSSSGL;PSEYLTNIHIRDKLA;SDYHDENMYYSQSS 3 8.4 0.98733 -0.47879 8.9125 0 0 0 6.34892 0 4.23297 3.16153 0 0 0 0 0 0 0 A0A8C0MRA2 A0A8C0MRA2_CANLF Vascular endothelial growth factor receptor 3 (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; vascular endothelial growth factor receptor activity [GO:0005021] EDCMAPCGS;GEVPLEEQCEYLSYDAS;LGACTKPN;LLLPEAHANNTGSYR;LNVVNLLGACTKPNGP;LSYDASQWEFPRERL;SHDKHCHK;SVDNQTDSGMVLA 8 6.7 1.0035 -1.6162 12.4073 6.6985 10.3968 0 0 6.76713 0 0 4.79883 6.19065 0 0 9.46356 8.65639 9.93369 A0A8C0MRC4 A0A8C0MRC4_CANLF Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) ECHDC1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] catalytic activity [GO:0003824] NKVSQLCMILSFNEIQWQIFNLKN;SATPQGKQLQGLQGLG;VGYKFNVQVRR 3 9.8 1.0019 -0.68924 0 0 9.52335 0 0 0 0 13.1094 0 0 0 0 12.2012 0 0 A0A8C0MRE4 A0A8C0MRE4_CANLF Gastrin-releasing peptide Canis lupus familiaris (Dog) (Canis familiaris) mast cell degranulation [GO:0043303]; neuropeptide signaling pathway [GO:0007218] extracellular space [GO:0005615]; neuron projection [GO:0043005] neuropeptide hormone activity [GO:0005184] ELPLVLLALV 1 7 0.99086 -0.27523 0 0 0 0 0 0 0 0 0 9.41287 0 0 0 0 0 A0A8C0MRF4 A0A8C0MRF4_CANLF Transmembrane protein 39A TMEM39A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097] endoplasmic reticulum membrane [GO:0005789] FLGYPFGVYVPLCCFHQDSRA 1 4.6 0.9847 -0.24626 0 0 0 7.18229 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MRH9 A0A8C0MRH9_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] QVSQGPGPCPLRH;VLVNAIYFKGRWNEQF 2 6.1 0.94136 0.059805 0 0 0 0 0 0 0 0 0 0 10.346 0 0 0 0 A0A8C0MRJ2 A0A8C0MRJ2_CANLF EF-hand domain-containing protein CALM2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] LTRMADGTITTKE 1 8.8 0.94073 0.059757 0 0 0 0 0 0 0 0 0 0 0 4.9102 0 0 0 A0A8C0MRJ4 A0A8C0MRJ4_CANLF Neuropilin NRP2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; axon guidance [GO:0007411] membrane [GO:0016020] heparin binding [GO:0008201]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor receptor activity [GO:0005021] GKHCGNIAPPTIISS;IDEEATECGENCSFEDDKDLQLPS;LTFHTDMAVAKDGFSA;LVSSRSGWFP;PIDEEATECGENC;SLNGRDWEYIQ;TDVPLENCMEH 7 10.5 0.97407 0.041729 9.02475 0 0 7.65378 0 0 7.21927 9.64641 12.2485 0 0 0 0 0 6.80761 A0A8C0MRJ8 A0A8C0MRJ8_CANLF Zinc finger protein 483 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ASLTKHRRIHTGEKPYMCNECGKAF;NKMTTISP;VISQEENP 3 5.5 1.0028 -2.5039 0 11.486 0 0 0 4.74561 0 0 0 0 9.03768 4.40946 0 0 0 A0A8C0MRK1 A0A8C0MRK1_CANLF "Actin, cytoplasmic 2 (Gamma-actin)" Canis lupus familiaris (Dog) (Canis familiaris) actin filament [GO:0005884] structural constituent of postsynaptic actin cytoskeleton [GO:0098973] ALAAHAPC;EEHPVLLTEAPLNPK;GDDAPRAVFPSIVG;LTEAPLNPK;RVAPEEHPV;RVAPEEHPVL;TEAPLNPK;VAPEEHPVL;VAPEEHPVLLTEAPLNPK;YASGRTTGIVMDSGDG 10 8.6 0.98929 -0.26592 12.326 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MRL8 A0A8C0MRL8_CANLF LIM homeobox transcription factor 1 beta LMX1B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837]" ARVGNPIDRLYSMQSSY;FVMRALECV;PYGNDSIFHD 3 9 1.0034 -1.1126 10.5695 0 0 0 0 0 0 0 0 8.25875 0 0 0 0 7.81558 A0A8C0MRM6 A0A8C0MRM6_CANLF TSPO associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) EDEEEDEEDEERP;ELADLSHSSGP;FSIPEEEEEEDEEDEE;KLFSIPEEEEEEDEEDEEEDE;LDSMQVRVRELE;PEEEEEEDEEDE;SDLSDIQEEEEEEEEEEL;SIPEEEEEEDEEDEEEDE;SIPEEEEEEDEEDEEEDEE 9 3.7 0.94377 0.086347 8.66647 0 7.44741 0 0 0 5.1102 0 10.9154 11.2726 6.84398 0 0 8.16012 10.7104 A0A8C0MRN9 A0A8C0MRN9_CANLF Sushi domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] AVPEAGGKGW;ETCLRWRSTKTADIE;GGGGGGGG;VGNGRTHCVDKNEC 4 6.7 0.99221 -0.17076 0 0 10.495 0 0 0 0 9.07294 0 0 0 0 0 0 0 A0A8C0MRP5 A0A8C0MRP5_CANLF C2H2-type domain-containing protein IKZF1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AEGPPRSNHSAQDSAVENLLLLS;FECNMCGYHSQDRCHQ;FVGDKCLSDMPYDSSA 3 9.3 0.96111 0.049233 0 0 0 0 9.13873 0 0 0 0 0 0 0 0 0 0 A0A8C0MRQ0 A0A8C0MRQ0_CANLF Proline rich transmembrane protein 4 PRRT4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APLPLFFLT;GSSTPWTSSLSP;SPFAPRESWRRA;VGPQPASSVTGVP 4 5.3 1.0029 -1.3322 7.87915 0 0 0 5.55019 0 0 0 0 0 0 0 0 7.95064 0 A0A8C0MRQ7 A0A8C0MRQ7_CANLF Groucho/TLE N-terminal Q-rich domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] CPAPLSASRGYQMPRGPG;EIAKRLNTILAQIMPFLSQEHQQQV;FLSQEHQQQVAQAVERAKQ;PGLLGNGSPIRAADASP;QPGQPGFKFTVAE;SIPGGKPA 6 9.1 1.0021 -1.4232 0 0 8.71414 0 11.4416 6.44847 0 0 10.0588 0 0 0 0 0 10.04 A0A8C0MRQ9 A0A8C0MRQ9_CANLF PX domain-containing protein PXDC1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] YHLVPFETDI 1 4.3 0.98974 -0.21447 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2709 0 A0A8C0MRR4 A0A8C0MRR4_CANLF Homeobox protein cut-like CUX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DLSGSARRKGKDQ;FGHYVLGLSQGSVSE;GVWKDHWWSTV;IFSTGPYS;NVGSMFQYWKRFDLQQLQRELDA;PWNKLTVRGKEPF;SLKKPPTA;VINWFHNYRALRRATG;YMYQEVDTIELT 9 9.1 0.99143 -0.13616 0 0 0 0 10.9999 0 0 0 0 0 0 0 0 0 0 A0A8C0MRR9 A0A8C0MRR9_CANLF P2X purinoceptor Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] DKAFLKSCQFGPKNPYCP;GVALMGAG;GVEFRTLMKAYG;VGLLYRLLQVSILTYLVVWVFLV 4 14 0.99012 -0.26592 0 0 0 0 0 0 0 8.76454 0 0 0 0 10.643 0 10.7957 A0A8C0MRT4 A0A8C0MRT4_CANLF Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] CHDAWDGYSCVCDKG;FPKELESSVFFSA;GPNAQIMYQIVEGNV;GPNAQIMYQIVEGNVPEVFQLDLL;GVEAVDHG;GVSSRLHLQILNNY;ITLALPLDY;LSASVEIQVSVLDINDNPP;PDDSATTRATL;QAQGRPQG;SAKGCELLSRNRTH;TTRATLLT;VEIQVSVLDINDNP;VLSTTKDDVFVFNIQN;VTVSDTNDHSPAFEQSEYRERV;YTCECLEDFTGE;YTMTELDYED;YVTNKSNSFPTGVIGRIP 18 7.2 0.99672 -4.6569 5.46241 9.63952 0 0 10.7871 5.2592 6.31461 11.3861 9.29669 10.8465 0 11.0323 0 0 9.24862 A0A8C0MRT9 A0A8C0MRT9_CANLF DNA replication licensing factor MCM5 (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] CRAKCGPRLSAEAA;DEDLADYLYKQPAEHLQLSD;EEEFRRLAALPNVYEVISKSI;GFTFKYRDELKRHYNLGEYWV;HYNLGEYWVEVEMEDLASFDE;PIGVYTSGKGSSAAGLTASVMRDPS;SFGGDPAA 7 17.2 0.95414 0.050633 0 0 0 0 0 0 0 0 0 0 0 0 7.86165 0 0 A0A8C0MRU8 A0A8C0MRU8_CANLF Solute carrier family 66 member 3 SLC66A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADLRGAGGAQLAGHQPP;GAPAESRSPQ;SGRRRGGAGRGGAGAEIPAG 3 9 1.003 -0.7876 0 0 0 0 6.95175 0 0 6.50776 0 0 6.5404 0 0 0 0 A0A8C0MRY1 A0A8C0MRY1_CANLF Fanconi anaemia group A protein N-terminal domain-containing protein FANCA Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] NLDDLLLEVEGPACKTLCLNQ;PLLSSLYRRLFVMLS;SALAGRSQELQGQGDPVG;VSWGRTRLSTVIF 4 4.6 0.94244 0.05962 0 0 0 0 0 0 0 0 0 0 7.864 0 0 0 0 A0A8C0MRY2 A0A8C0MRY2_CANLF UBA domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLILVEAM;LLLPHCQRFFVYD;PLEVSEEQNRGS;RCAGSAPA 4 10.6 0.98951 -0.26592 0 0 9.80348 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MS18 A0A8C0MS18_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ITMPDFRLYYEAVV;MDAFLESHKL;MNEKGEITTNT;YYEQLYANKLGNLQEMDA 4 7.5 0.91699 0.10944 0 7.15198 0 0 0 0 7.1644 6.5689 0 0 0 0 0 0 0 A0A8C0MS23 A0A8C0MS23_CANLF Galectin Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] DVREFKVAVNGVHS;IVCNTLKNEKWGW;KNEKWGWEEI;VNGKHILL 4 13.2 1.0009 -0.63661 0 0 0 0 0 8.49394 0 0 0 0 7.28873 0 0 10.9503 0 A0A8C0MS35 A0A8C0MS35_CANLF Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) NOD2 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; autophagy [GO:0006914]; innate immune response [GO:0045087]; regulation of apoptotic process [GO:0042981] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; mitochondrion [GO:0005739] AENLCLEEIYTE;HERHCSPTDPTS;LLHLGGWLSGVW;SLEGFESILDW 4 4.8 0.86762 0.18681 0 0 0 0 8.25526 7.41752 0 0 0 3.68516 0 4.80142 0 0 0 A0A8C0MS41 A0A8C0MS41_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GERPHKCKE;IQYEKSHNKEKDPKC;NLIKHRRVHESKK 3 8.1 1.0024 -0.99033 9.69777 0 0 0 0 9.12768 0 0 0 0 0 0 0 0 8.50522 A0A8C0MS51 A0A8C0MS51_CANLF Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; glucosylceramide catabolic process [GO:0006680] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] glucosylceramidase activity [GO:0004348] EAYCQQRVF;IPHDIGDPDDEP;YHALYPRAW 3 3.4 1.0012 -0.99786 0 0 6.13769 0 0 0 0 0 8.00809 0 0 9.12435 0 0 0 A0A8C0MS85 A0A8C0MS85_CANLF UDENN domain-containing protein DENND2B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERK1 and ERK2 cascade [GO:0070374] guanyl-nucleotide exchange factor activity [GO:0005085] LVQRINSIYNAKRGKKRLKKL;RQMDDEDTLLPR;VEGVAACLPL;VGDLPKENPYE;WQHTFIPVLPASMIDIVCCPTPFLV 5 7.4 0.98713 -0.40678 0 7.6962 8.60496 6.72083 0 0 0 0 0 0 0 0 0 0 6.59376 A0A8C0MS95 A0A8C0MS95_CANLF Transmembrane protein 168 Canis lupus familiaris (Dog) (Canis familiaris) nuclear membrane [GO:0031965] GGGGGGGD;IETYGCDYSTSGLSFDT;IWREHCEDEETLCEYAVAM;THLWYFVIPGFSIFGI;TYPLVHLANWLCGLNLFWICKTCF;VILLVVALAMLIIDL;WREHCEDEETLCEYA 7 8.9 0.68266 0.29394 0 0 0 9.34527 7.91654 4.83749 10.2336 0 8.86576 0 0 0 0 5.96218 0 A0A8C0MSA4 A0A8C0MSA4_CANLF Syntaxin binding protein 3 STXBP3 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; cellular response to type II interferon [GO:0071346]; insulin secretion [GO:0030073]; intracellular glucose homeostasis [GO:0001678]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of glucose import [GO:0046325]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; specific granule [GO:0042581]; tertiary granule [GO:0070820] syntaxin binding [GO:0019905] DLWVRIRHRHIAV;DTYKYKTDGK;NELTKESVDI;NYYKIDEKSQI 4 7.1 1.0041 -1.0982 9.54121 0 0 0 0 0 0 0 11.1024 0 0 0 0 0 0 A0A8C0MSA8 A0A8C0MSA8_CANLF Ig-like domain-containing protein JAML Canis lupus familiaris (Dog) (Canis familiaris) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; monocyte extravasation [GO:0035696]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672] plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] IIVGIVCVTILLLPVLILIVKRT;ILLLPVLILIVK;IVCVTILLLPVLILIVKR;IVGIVCVTILLLPVLILIVKR;LILMPVLLDYSL;LLLPVLILIVKR;PVLILIVK;QLVIIVGIVCVTILLLPVLILIVKR;TILLLPVLILIVK;VGIVCVTILLLPVLILIVK;VGIVCVTILLLPVLILIVKRT;VIIVGIVCVTILLLPVLILIVKRT 12 9.5 1.0017 -1.2536 8.7267 0 4.81193 0 0 7.43796 6.31201 0 6.40158 0 5.9384 4.27932 7.28207 6.5419 0 A0A8C0MSE1 A0A8C0MSE1_CANLF hydroxyisourate hydrolase (EC 3.5.2.17) LOC489647 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; purine nucleobase metabolic process [GO:0006144] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; hydroxyisourate hydrolase activity [GO:0033971] ATDVDDHEN;IVYTILSQDP;TEAVTWPHPGWIL;TVQAADLQ 4 5.4 1.0027 -1.3474 10.4251 0 0 0 9.2949 0 0 0 0 0 0 0 0 0 0 A0A8C0MSE7 A0A8C0MSE7_CANLF Nuclear factor 1 NFIC Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKREKKKKKKKGKKK;GGKQAKREKKKKKKKGKKKEKK;KKKKGKKKEKKRQTEKKKNHHKNKP;KKKKKKKGKK;KKKKKKKGKKK;KKKKKKKGKKKEKK;TAIRYPPHLNPQDPLKDL 7 7.1 0.6745 0.28068 5.14233 0 0 0 0 0 0 6.1766 0 4.74077 4.5879 0 6.21486 0 0 A0A8C0MSE8 A0A8C0MSE8_CANLF Sugar phosphate transporter domain-containing protein HSD17B3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAAAALPVSDALPRAG;GGGGGGGG;LRPQDMTTGRRAEGADPGPG;SFAKVVLEVNGT;VGSDHWSRRWDWES 5 15.8 0.99253 -0.040248 0 0 3.34582 10.6692 10.7169 0 0 10.1792 6.15561 0 9.98499 0 0 0 0 A0A8C0MSF4 A0A8C0MSF4_CANLF START domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] ENVSSFEIIE;LQPLRQGHRL;RDKWDENVS;SAGSDPANLGAGRGPS 4 9.5 1.0017 -0.7508 0 0 0 0 0 0 0 0 8.08497 9.44667 11.5479 9.93239 0 0 0 A0A8C0MSG1 A0A8C0MSG1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DFNLALSVLDRSCKHN;MDAFLESHKL;MNEKGEITTNT;NNTLGDFNLALSVLDRSCKH;PSICCLQETHFRQ 6 9.1 0.99347 -0.17451 0 0 0 6.29622 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MSG2 A0A8C0MSG2_CANLF G-protein coupled receptors family 3 profile domain-containing protein GRM7 Canis lupus familiaris (Dog) (Canis familiaris) "regulation of synaptic transmission, glutamatergic [GO:0051966]" plasma membrane [GO:0005886] group III metabotropic glutamate receptor activity [GO:0001642] AATMSSRLS;AEGAITIQPKRATVEGFDAYFTS;ALIQKDTSDVRCTNGEPP;CDGYQYQFDEMTCQ;LPPPLPGG;QFDEMTCQHCPYDQ;RRYDFFSRVVPPDSFQAQ;SDRPNGEAKTELCENVDP;TGQERIGKDS;WGESGSSRGRGEGVG 10 13.3 1.001 -0.6378 0 10.7913 0 10.7638 7.80542 15.5582 11.5559 11.5325 8.44303 0 10.8379 0 0 0 10.3731 A0A8C0MSG5 A0A8C0MSG5_CANLF C-X-C motif chemokine 16 (Transmembrane chemokine CXCL16) CXCL16 Canis lupus familiaris (Dog) (Canis familiaris) lymphocyte chemotaxis [GO:0048247]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; receptor-mediated endocytosis [GO:0006898]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341] extracellular space [GO:0005615]; membrane [GO:0016020] chemokine activity [GO:0008009]; low-density lipoprotein particle receptor activity [GO:0005041]; scavenger receptor activity [GO:0005044] GPSSCCLCAL 1 2.3 0.98933 -0.26296 0 0 0 0 0 0 0 8.37695 0 0 0 0 0 0 0 A0A8C0MSJ9 A0A8C0MSJ9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PLFYSIEMDFCETV;SHKLQISKVRKK 2 10.1 0.91487 0.11154 0 0 0 0 0 8.37556 0 2.47384 0 0 0 0 0 0 0 A0A8C0MSK2 A0A8C0MSK2_CANLF U3 small nucleolar RNA-associated protein NOL7 C-terminal domain-containing protein NOL7 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] RNA binding [GO:0003723] EEDDEDGDDELDDE;KTLLKEKRKRRE;SYLAVRLKDQDLR;SYLAVRLKDQDLRD 4 15.3 0.93504 0.060769 0 0 0 0 0 0 4.06419 0 0 0 0 0 0 0 0 A0A8C0MSL3 A0A8C0MSL3_CANLF PHD-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] CKNHSGNDERDEEDEER 1 13.8 0.97919 0.046227 0 0 0 0 0 0 0 0 11.7824 0 0 0 0 0 0 A0A8C0MSP0 A0A8C0MSP0_CANLF RRM domain-containing protein RBM28 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] EEDMEEEEEEEDDTEEEED;EPKHQELSKENGREEE;EQEDEDMQIS;FIRNLSFDSEEE;GVRLKECRVMRDLKGVH;NQLVEQYKQKLL;QFKNLLEAGKALKS;REEEDMEEEEEEEDDTEE;RLCLHNLPKGVDDKELRKLLLNA;SEEQEDEDMQ;VEQVELPDGKKRRKVLVL 11 19.4 0.98897 -0.52293 9.5073 0 0 0 0 7.18329 6.58631 0 8.44116 8.16586 0 0 0 9.65589 0 A0A8C0MSP8 A0A8C0MSP8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KNTRFSVMRH;LPPLPDSTGAFNFERPCYL;MRHYHGQNQQ 3 24.3 0.99035 -0.53405 0 0 0 0 0 9.37615 0 0 0 0 0 0 0 0 11.5394 A0A8C0MST9 A0A8C0MST9_CANLF CD164 molecule CD164 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATTTATTSGTTNITLSP;SYCSHNTTVSDCQV 2 16.7 0.98987 -0.21431 6.40946 0 0 0 8.29485 0 7.07692 0 0 0 0 0 0 0 0 A0A8C0MSX8 A0A8C0MSX8_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] catalytic step 2 spliceosome [GO:0071013] helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] AGRVAAGKCFRLYTA;PEFPVDIFYTKAPEA 2 5.7 0.98473 -0.24659 0 0 0 2.18406 0 0 0 0 10.7648 0 0 0 0 0 0 A0A8C0MSZ1 A0A8C0MSZ1_CANLF Saposin B-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742] VGPSQIQEAIQKATT 1 9.2 0.95144 0.05389 0 0 0 0 0 0 0 0 0 0 0 0 0 6.72751 0 A0A8C0MSZ2 A0A8C0MSZ2_CANLF Amine oxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] oxidoreductase activity [GO:0016491] GPAPPSGCWPLR;LGAAQRLRAH;PGAGARPALHLL;QDVWFKKL;VPVLFEIRNLFFFKYFIYLF 5 6.5 0.97336 0.048206 0 0 6.82043 0 0 7.97591 0 0 0 0 0 0 0 0 0 A0A8C0MSZ6 A0A8C0MSZ6_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5" SMARCA5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; nucleosome binding [GO:0031491] ADVEKSLPP;DKENVYDE;EDYCMWRNYEYCRLDGQT;EDYCMWRNYEYCRLDGQTPHDERQE;EVEGKTPEEV;IDEAEPLN;LEDYCMWRNY;LSKPAAPA;VEERIVERAE;VLLPGEWDVCVTS;VLRPFLLRRIKADVEK 11 10.3 0.99755 -3.5462 8.81932 10.0947 8.455 0 0 0 7.65478 0 11.1989 0 5.6379 10.9321 0 7.62607 9.85343 A0A8C0MT06 A0A8C0MT06_CANLF PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) PSIP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AEQRQHEEANKT;DAQDSNQPQHNGD;GVTSTSDSEEEGDDQK;TLKKIRRFK 4 9.5 1.0022 -1.0133 0 0 0 0 6.64032 0 0 0 0 0 6.85611 5.02246 0 0 0 A0A8C0MT31 A0A8C0MT31_CANLF Family with sequence similarity 217 member A FAM217A Canis lupus familiaris (Dog) (Canis familiaris) QLWSYPLNEGS;VEESFTEEPSEVF 2 4.7 0.99164 -0.54821 0 0 0 0 0 0 0 0 0 0 0 10.5398 0 0 10.8521 A0A8C0MT33 A0A8C0MT33_CANLF G2 and S phase-expressed protein 1 N-terminal domain-containing protein GTSE1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LSRKSSSSGSVSAV;LSRKSSSSGSVSAVI;SLGGVTFEQ 3 3 0.98722 -0.33552 12.0063 0 0 8.47541 14.5126 0 0 0 0 0 0 0 0 0 0 A0A8C0MT54 A0A8C0MT54_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IGPQGLWT;PFKCMECEKAFSCSSDYIVHQRIHT 2 4.9 0.98706 -0.22986 0 0 0 0 0 6.82439 0 0 0 0 11.2652 0 0 0 0 A0A8C0MT63 A0A8C0MT63_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] CFLNRGQDEDGDEDEEEGE;DPMEMEPETMET;EADYRSLA;EATRQVSCLF;LIPETSGKGMSYIP;LSVSEEQQTSD;LVKVVNSETQRQ;PVKVRFSEEV;SLQNDEIPVSLIDA;VAFEYLYVQSCNDVVQE 10 7.8 0.997 -0.59759 8.83406 0 9.48206 10.1524 10.6234 0 7.34376 0 0 7.35394 8.29604 0 8.18809 9.34558 0 A0A8C0MT66 A0A8C0MT66_CANLF Glucose/Sorbosone dehydrogenase domain-containing protein CYP46A1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol catabolic process [GO:0006707] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] cholesterol 24-hydroxylase activity [GO:0033781]; heme binding [GO:0020037]; iron ion binding [GO:0005506] EGITASRNTLAKF;KPLSRKVKLIL;PHKLGKSV;PRFTYFPFSLGPRSCIGQQFAQ;RLLLPPPAGQ;SLVSLMET;VFHKTSVI 7 8.7 1.0035 -2.0313 0 8.38642 0 0 0 0 0 11.5258 0 0 11.0695 0 0 9.30886 0 A0A8C0MT73 A0A8C0MT73_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PASK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EDQRDIPGRSPP;GLWLLQRGHQPQ;ILVANDKACQLLGHSSHA;IPGRSPPAHNQQ;SRESPPCVLPAPEAGP;VGGLWLLQ;VLMGNPRPHAPAL;WMFASQGG 8 6.4 0.96003 0.049233 0 0 0 0 0 0 0 10.5288 0 0 0 0 0 0 0 A0A8C0MT81 A0A8C0MT81_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; nucleoplasm [GO:0005654] CKIHKVLIRSI;KPYSCNECGKAF;SSLTQHQRIHTGE 3 6.9 0.94118 0.085931 0 0 0 0 0 0 0 0 5.54142 0 0 7.92374 0 0 0 A0A8C0MTA0 A0A8C0MTA0_CANLF UDENN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] DLVLKLKNKLLQADRERLPV;GLYRHFLKSPNFDGW;LDSKPGVYTSYKPYLNRDE;SPLKYFSDF;VLKLKNKLLQ 5 19 0.98738 -0.23118 0 0 9.44721 0 0 0 6.34419 7.15714 0 10.2717 12.3856 0 0 4.25096 9.8461 A0A8C0MTB3 A0A8C0MTB3_CANLF cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) MOCS1 Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] "4 iron, 4 sulfur cluster binding [GO:0051539]; GTP binding [GO:0005525]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]" AEELSRRRQFLREHAV;ASCRAWGPTGV;RVSFSNRMS;VGIRASCRAWGPT 4 6.9 0.9816 -0.24889 0 0 0 0 7.99808 0 0 0 0 0 0 0 0 0 0 A0A8C0MTB5 A0A8C0MTB5_CANLF Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAREDLFCYWEK;ELHGEGDQDE;ETRKGKKE;EVIDVHNRVRMVTVG;RKPTKILELTRLLPLKFV;TSTGQSEGYMSERDGSQ 6 12.6 0.97907 0.046227 0 0 0 0 3.41724 0 0 0 0 0 0 0 0 0 0 A0A8C0MTB7 A0A8C0MTB7_CANLF WW domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] ANKKEVPENPVD;DEAKKEHTHLLESNQQ;EAEERKQRTELLGHLTRE;EANRKWLE;EDMSSTSSEACSLPHSE;LDVDVLSP;MLEQLKEEME;PAAIKKKDKKKK;QSVRSSSELLKNL 9 7.9 0.97867 0.046227 0 0 0 0 0 0 0 7.38802 0 0 0 0 0 0 0 A0A8C0MTC3 A0A8C0MTC3_CANLF "FYVE, RhoGEF and PH domain containing 2" FGD2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GAGADGCRVPPLLPGVREAAH 1 6.2 0.97646 0.047759 0 0 0 0 6.76607 0 0 0 0 0 0 0 0 0 0 A0A8C0MTE0 A0A8C0MTE0_CANLF AN1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] PKGEGAGGGAC;TSTVPSPSRTL 2 6.7 0.98787 -0.2252 0 0 0 0 0 0 0 0 0 0 0 6.88728 12.1397 0 8.55401 A0A8C0MTH3 A0A8C0MTH3_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DIIQQNKERWKE;DLVNAEEK;RRLLDTEDELSDIQ;TDTSSYGASSLS;TRRLLDTEDELSDIQ;VSAAYRLMQEEEMNVLIN 6 12 1.0023 -0.65356 10.7028 0 8.59066 0 0 13.0787 0 0 0 0 7.73335 0 0 0 0 A0A8C0MTI9 A0A8C0MTI9_CANLF Fibrinogen alpha chain FGA Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; protein polymerization [GO:0051258] fibrinogen complex [GO:0005577] signaling receptor binding [GO:0005102] AGEAGTEAEREIF;AGEAGTEAEREIFRGEYSI;DLLPPKDRQ;EAGTEAEREIF;EAGTEAEREIFRGEYS;EAGTEAEREIFRGEYSI;EFIAEGGGV;EGEFIAEGGG;EGEFIAEGGGV;EGEFIAEGGGVR;EIFRGEYS;ELEDWAGNQ;FIAEGGGV;GAGEAGTEAEREIF;GAGEAGTEAEREIFRG;GAGEAGTEAEREIFRGEY;GAGEAGTEAEREIFRGEYS;GAGEAGTEAEREIFRGEYSI;GEAGTEAEREI;GEAGTEAEREIF;GEAGTEAEREIFRGEY;GEAGTEAEREIFRGEYS;GEAGTEAEREIFRGEYSI;GEFIAEGGGV;GSTGPGNT;GTWSSGSTGPGSTGPGSTGTWSS;IRSCQGSCSRALERRT;KEGEFIAEGG;KEGEFIAEGGGV;LSHTFAGSLDD;NSKEGEFI;NSKEGEFIA;NSKEGEFIAE;NSKEGEFIAEG;NSKEGEFIAEGG;NSKEGEFIAEGGG;NSKEGEFIAEGGGV;PSGAQSGI;RVGSEAEGYALQ;SKEGEFIAEG;SKEGEFIAEGG;SKEGEFIAEGGGV;SQLQEAPLEWKA;SYKGAGEAGTEAEREIFRGEYSI;TEAEREIF;TEAEREIFRGEYSI;THIMGSDSDIFTNIG;THIMGSDSDIFTNIGTPEFPSSG;TNSKEGEF;TNSKEGEFI;TNSKEGEFIA;TNSKEGEFIAE;TNSKEGEFIAEGG;TNSKEGEFIAEGGG;TNSKEGEFIAEGGGV;TNSKEGEFIAEGGGVR;TPPGILLPSRKEF;TTNSKEGEFIAEGGGV;VELEDWAGN 59 23.7 0 323.31 19.8891 19.6785 19.8001 18.9167 19.0118 19.2008 20.6686 20.5761 20.6435 20.1566 19.9795 20.0729 20.0768 19.87 19.8967 A0A8C0MTK1 A0A8C0MTK1_CANLF Calmin CLMN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] actin binding [GO:0003779] AADLDDRRNRMLT;EFMHQIIDQAL;FVQQPDLMYFILFLW;MALLEVLSGRNLLH;QTSQSSPSWNGEPEG;SKVFVCDKPESMK;SQSSPSWNGEPEG;TGNLSRNSP 8 9.1 1.0035 -1.9651 0 0 0 6.80954 6.83504 0 10.4014 0 0 15.5499 8.23735 0 0 0 9.49257 A0A8C0MTK7 A0A8C0MTK7_CANLF poly(A)-specific ribonuclease (EC 3.1.13.4) Canis lupus familiaris (Dog) (Canis familiaris) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535] AAPHSHQRTAERG;DKYATRQLYGYCP;FFKTEKFTLVQ;LSCNADIISLQE;LSMKTRGARRRRRRRRWRRRRRRG;PQLNTLGILG;TIMSSEEA 7 9.8 1.0035 -2.0498 0 8.02203 10.5089 0 9.01167 10.8049 0 0 0 0 0 5.52535 4.72694 0 0 A0A8C0MTM6 A0A8C0MTM6_CANLF Integrator complex subunit 7 INTS7 Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] KPGLFRKIQSV;LATPVDLKLKLIPIL;LESLLVLCSQDDSPG;PHLSQSVVETL;TPLNPLSFQCEFV 5 7.3 0.72973 0.25233 8.25602 0 0 7.3637 7.65284 7.70798 0 0 0 9.6349 0 6.66278 7.07328 0 7.68636 A0A8C0MTN5 A0A8C0MTN5_CANLF Superkiller complex protein 8 (WD repeat-containing protein 61) Canis lupus familiaris (Dog) (Canis familiaris) AFCPDDTHFETCVHTFFDHQDQV 1 11.3 0.97812 0.046253 0 0 0 0 0 5.6722 0 0 0 0 0 0 0 0 0 A0A8C0MTR2 A0A8C0MTR2_CANLF Cilia- and flagella-associated protein 157 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] DLLENTQKVMARH;LEQSLGQLQQDN;LQKEELTEKFESLE 3 7.5 0.99424 -0.55797 0 0 0 0 8.61364 0 0 11.2647 0 0 0 0 0 0 0 A0A8C0MTW1 A0A8C0MTW1_CANLF IQ motif containing F5 Canis lupus familiaris (Dog) (Canis familiaris) HIRLHYCHLLHAVRIIQVYWRWHNC;YSQQEWAVVKLQSLVRMWHIRLHY 2 29.1 0.9448 0.07684 0 0 6.38018 0 0 0 0 0 9.9582 0 0 0 0 0 0 A0A8C0MU02 A0A8C0MU02_CANLF "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial" NDUFS1 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" DVAAIAGGLVDAEALVA;LSKSPKGCVRTTATTASNLIE;QCTRCIRFASEIA;SPNLVRYDDVEG 4 9.2 0.98503 -0.43979 0 12.875 0 0 0 0 8.62527 0 0 0 0 10.9227 12.5017 0 0 A0A8C0MU10 A0A8C0MU10_CANLF Mitochondrial carrier 1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] mitochondrial outer membrane [GO:0005741] VEARARDPPP;VGLIPHLLGDVV;YLSVQVSK 3 6.9 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 8.7698 0 0 A0A8C0MU18 A0A8C0MU18_CANLF Ankyrin 3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] GEGGVNGY;LVSFMVDARGGSMRGSRH;QYFAVVSRIKQESN;RMTACCYKQGEG;RRQSFASLALRKRYS;SLEDSKLEDSMPL;VTAEDTSLEDSK 7 8.4 0.94673 0.05044 0 0 0 0 0 0 0 0 0 0 0 9.47687 0 0 0 A0A8C0MU27 A0A8C0MU27_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DYELTSSYSL;EDQNDHSP;EPLDLVLLRRLDREAA;FEIMPGASSGLFKINPD;FLDFEVRNEVQLI;FLPSEYPSKQ;FMLDESSGLLTTTC;IFILIVLIVRHKQKDTPN;IVHVLDEND;LDVNDHSPTFL;LDYEMTSHYL;LLYQASVREDAQV;LTVWLDIEGVDE;LVDEASGAFTIDPV;SIFSGNEDGVFSLCSN;SPVGTVKAKESLNSSE;VEDQNDHSPSFQEELI;VEIRVNDVN;VIASDQGV;VPQGVIGK 20 7.2 0.99706 -6.8283 0 8.2867 8.35081 9.96636 9.24783 10.0637 12.4184 0 0 8.62187 0 5.46604 0 10.1288 11.0856 A0A8C0MU48 A0A8C0MU48_CANLF urocanate hydratase (EC 4.2.1.49) (Imidazolonepropionate hydrolase) Canis lupus familiaris (Dog) (Canis familiaris) L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] urocanate hydratase activity [GO:0016153] DHCIERLREARKRKE;QHIMGDIFSLGFGPFRWVCTSGDP;VGDAFRGATWVALH;VIPNYSSRAE 4 9.6 1.0037 -0.81501 0 0 0 0 0 0 0 10.1713 0 0 0 0 0 0 7.08247 A0A8C0MU53 A0A8C0MU53_CANLF HTH La-type RNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829] RNA cap binding [GO:0000339] AHSLPTAVPESPRIHPV;EVEIVDEKMRK;EVEIVDEKMRKKIEPEKWPIP;QEQEELDFLFDEEIEQIE;SEDEAQSSNQRKRGWRRDREKRD;TDWSDNDSDY;VINDGLYYYEQDLWMGE 7 10.1 0.9932 -0.27933 0 11.2953 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MU64 A0A8C0MU64_CANLF Phospholipid/glycerol acyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] O-acyltransferase activity [GO:0008374] EMCHGCSDFQH;LPEFAEYLGVP;LTLCQFHNRVEIEFL;SEEEKKDPALYAS 4 8.1 0.97865 0.035491 3.83956 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MU81 A0A8C0MU81_CANLF SH3 domain-binding glutamic acid-rich-like protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] SH3 domain binding [GO:0017124] AQMLRCLYLPYSSA 1 10.3 0.93707 0.060924 8.42063 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MU90 A0A8C0MU90_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) myelination [GO:0042552]; neuron differentiation [GO:0030182]; oligodendrocyte cell fate specification [GO:0021778] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] FQHWGGMPCPCSMC;GGGGGGFQ;GGGGGGGG;LVSSRPSSPEP;PCPCSMCQV 5 10.2 1.003 -0.73098 0 0 10.1891 9.12585 0 10.8219 0 0 4.2225 0 0 0 0 0 0 A0A8C0MU97 A0A8C0MU97_CANLF Fem-1 homolog B FEM1B Canis lupus familiaris (Dog) (Canis familiaris) branching involved in prostate gland morphogenesis [GO:0060442]; epithelial cell maturation involved in prostate gland development [GO:0060743]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] death receptor binding [GO:0005123]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ANDINYQDQI;DNYECNLYTFLY;FSQMIHLNETVKAPDIECVLRCSVL;NSNTPVDDFHTNDV 4 9.7 1.0017 -0.91448 10.5753 20.0311 0 0 8.01659 15.9152 0 8.83983 0 0 0 0 0 0 0 A0A8C0MUB1 A0A8C0MUB1_CANLF ADAM metallopeptidase domain 18 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] ALVITLEAFSVVIAQ;DEFKRMASQPEFE;EDITYTSN;KCRDTDKQCAELFGKFAK 4 7.5 0.98523 -0.25315 0 0 0 0 0 0 13.2125 0 0 0 0 0 0 0 0 A0A8C0MUE7 A0A8C0MUE7_CANLF Myb/SANT-like DNA-binding domain-containing protein 4 MSANTD4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] PQSPEFEIEEEEEI;RRLDIEAERLQVEKERLQVE 2 9.9 0.99266 -0.27188 0 0 0 0 0 0 0 0 0 11.1582 0 0 0 0 3.87204 A0A8C0MUF5 A0A8C0MUF5_CANLF OCEL domain-containing protein ISYNA1 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] transcription elongation factor complex [GO:0008023] SLPLLTDCAQPS;VGLDPRSPGSHPRLQAALNHCAT 2 5.5 0.98962 -0.27373 9.43425 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MUH6 A0A8C0MUH6_CANLF Protein Wnt Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182]; regulation of gene expression [GO:0010468] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] CHCIFHWCCYVSC;FADARENRPDARSA;GVKLGIQECQHQFRG;IFHWCCYVS;RCASDKPESHFQSQVDF 5 13 1.001 -0.62974 0 0 0 0 9.35462 0 0 10.0193 8.41304 0 0 0 0 10.5308 10.1934 A0A8C0MUI5 A0A8C0MUI5_CANLF Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) TPM2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin filament [GO:0005884] actin filament binding [GO:0051015] AEDSDRKYEEV;ILEGELERSEERAEVAERLKPEQSL;LQKLEEAEKAADESERGM 3 18.6 0.99218 -0.042561 0 0 0 0 0 0 0 0 0 0 10.1539 10.1977 0 0 12.0477 A0A8C0MUK7 A0A8C0MUK7_CANLF MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] KRRHFNELEASVVVQDV;LLTPCGSAEYMAPE;PQRSPHPSSHRALHPSGP;VGHCGSDCGWDRGEA 4 8.5 0.98569 -0.42203 0 8.91931 0 0 0 0 0 0 0 9.19734 0 4.96315 0 9.91648 0 A0A8C0MUM9 A0A8C0MUM9_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; calcium ion binding [GO:0005509] ALDLGWARRSTQGP;GVTELSVTSLFQAI;LPEFAEYLGVP;LTLCQFHNRVEIEFL;SEEEKKDPALYAS 5 10.4 1.0027 -0.9824 0 0 8.65084 0 0 0 0 0 0 0 9.52123 0 10.7106 0 0 A0A8C0MUR2 A0A8C0MUR2_CANLF Cell division cycle associated 5 CDCA5 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] chromosome [GO:0005694]; nucleus [GO:0005634] APVRKPIVLKKIVAH;ISPPVVKEKRKKRKV;SERRTRSGGATRHSGSR;VTPTTTPVLYPVNVESN 4 25.5 0.52353 0.46462 0 0 0 5.99707 0 0 10.4334 0 0 0 0 0 0 5.33024 0 A0A8C0MUS2 A0A8C0MUS2_CANLF Heat shock protein HSP 90-beta HSP90AB1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to heat [GO:0034605]; protein stabilization [GO:0050821] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; uridine transmembrane transporter activity [GO:0015213] ASAAMICAIASGSELSESAFG;EIFLRELISNASD;VGRTRKKR 3 6.8 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.64027 A0A8C0MUS4 A0A8C0MUS4_CANLF Gasdermin C Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] membrane [GO:0016020] DNRSVNVWGSCFLPFDTFFKG;GSSLQFQAV;KQLHEEIFQEV;PHNWKDLQKRK;TINSGFIP;TVELTDTTVLCDNRSV 6 14 1.0033 -1.7039 0 11.4507 11.3105 0 10.6751 0 6.04288 0 0 0 0 0 10.9219 0 0 A0A8C0MUT0 A0A8C0MUT0_CANLF Fibrillin 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] CTDIDECEDNPNICDGGQ;DECREIPGVCENGV;DECSIMNGGCETFCTNSEGSY;EECTLPVAGRHRMDACCCSV;GCETFCTNSEGSYECSCQ;GTCSNTEG;GYPPPPLG;IDECQRDP;MMTCEDINEC;NNDCIDVDEC;PVCESGCLNGGR;SCEDVDECEGNHRCQHG;TPGDFECKCDEGYE;TQHHTACIDNNE;VGRAWGHPCEMCPAQPH;VGSFQCQCNEGYE;VILEDIDE;YHCLCKNGYTPDITGTSC;YTSHGADANLEAGNV 19 9 0.98912 -0.26308 0 0 0 0 0 0 0 0 0 0 11.7014 0 0 0 0 A0A8C0MUT2 A0A8C0MUT2_CANLF Sulfurtransferase Canis lupus familiaris (Dog) (Canis familiaris) thiosulfate sulfurtransferase activity [GO:0004792] AAAGGSPRRPAAPPP;LALAPDRRRSWRV 2 3.7 0.99409 -0.060902 0 0 14.1677 6.65005 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MUT3 A0A8C0MUT3_CANLF Leucine rich repeat neuronal 2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] SELNYLANLTELDLSQ;VDAILDMNF 2 7.4 1.0026 -0.98092 0 0 0 0 0 7.39968 0 0 0 0 0 0 10.3584 0 0 A0A8C0MUT7 A0A8C0MUT7_CANLF Zinc finger protein 566 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLQCSSFRDDWECNGQFEKQHD 1 5.3 0.9727 0.046699 0 0 0 0 0 0 7.41481 0 0 0 0 0 0 0 0 A0A8C0MUZ1 A0A8C0MUZ1_CANLF Tubulin--tyrosine ligase-like protein 9 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] cilium [GO:0005929] ATP binding [GO:0005524]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] EGEWDFYWCDVSWLRENFDHTYMDE;HTYMDEHVRISHFRN;KGHGLSKGKEREQRASIR;LVMSWSGHGRCNVHLTNVAVQKT;TNTHLGCINDRSKQL;VGGFDLMWND;YVAQRYIENP 7 25.5 1.0023 -0.66751 8.58613 0 0 9.71593 0 0 0 8.54531 0 12.0251 0 0 0 0 0 A0A8C0MV04 A0A8C0MV04_CANLF EF-hand domain-containing protein CETN3 Canis lupus familiaris (Dog) (Canis familiaris) spindle pole body duplication [GO:0030474] microtubule organizing center [GO:0005815] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] SDEELRAMIEEF 1 7.4 0.94254 0.05044 0 0 0 0 5.89222 0 0 0 0 0 0 0 0 0 0 A0A8C0MV06 A0A8C0MV06_CANLF Prolactin-induced protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] APNEEISVTVRVQTE;FYWDFRVNSKYRALTHIIDKEDIC 2 27.3 0.98679 -0.23455 11.9101 0 0 0 0 0 0 0 0 0 0 0 0 6.98789 0 A0A8C0MV15 A0A8C0MV15_CANLF Spermatogenesis-associated protein 6 N-terminal domain-containing protein SPATA6L Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] myosin light chain binding [GO:0032027] LHPEASLATFQHSRSPSPLLDQ;LVSPVWEEL;YEDNTRDFLFPEP 3 10.7 1.0041 -0.82724 0 0 8.36715 0 6.86703 0 0 0 9.21417 0 8.88243 0 0 0 8.76842 A0A8C0MV17 A0A8C0MV17_CANLF Protein kinase domain-containing protein CDK1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic G2 DNA damage checkpoint signaling [GO:0007095] nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] RIFRYFCLIFKLLR 1 6.1 0.93186 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.41481 A0A8C0MV19 A0A8C0MV19_CANLF Armadillo repeat-containing domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DFFESESEDEYYKESWFLPGE;EETSNESGFWSADETS;KTESQTESLAQTNAVAWPLVST 3 7.5 0.97633 0.047946 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8119 A0A8C0MV27 A0A8C0MV27_CANLF Sulfatase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787] CQSRYDQCHHPY;YGDNVQEMDSMVGKI 2 4.9 0.98974 -0.2653 0 0 0 0 0 7.92351 0 0 0 0 0 0 0 0 0 A0A8C0MV37 A0A8C0MV37_CANLF KASH domain-containing protein SYNE3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nuclear envelope [GO:0005635] ALPLQLLLLLLLL;ALPLQLLLLLLLLLLL;ALPLQLLLLLLLLLLLLLPV;ALPLQLLLLLLLLLLLLLPVG;EAALAESS;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLL;LLLLLLLLLLLLLPVGEENR;LLLLLLLLLLLLPV;LLLLLLLLLLLLPVG;LLLLLLLLLLLP;LLLLLLLLLLLPV;LLLLLLLLP;LLLLLLLP;LPLQLLLLLLLLLLLLLPVGE;PLQLLLLLLLLLLLLLP;PLQLLLLLLLLLLLLLPVGE;QAQLLRLQGLQ;QMEAMRPLIQGNPSHQHK;RRACCVALPLQLLLLLLLLLLLLL;VALPLQLLLLLLLLLLLLL;VALPLQLLLLLLLLLLLLLPVGE;VDEFQLWLKAMMEKVSS 27 8.7 1.0027 -1.3256 0 4.51027 0 6.30905 3.69343 8.55907 8.6799 0 8.65474 6.32414 0 5.72189 7.71163 10.4308 8.59268 A0A8C0MV72 A0A8C0MV72_CANLF DnaJ homolog subfamily A member 1 Canis lupus familiaris (Dog) (Canis familiaris) protein refolding [GO:0042026] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] HYNGEDDEHHPRGGVQCQT;MDQVELVDFDPNQ 2 8.9 0.99281 -0.55496 0 0 0 0 0 0 0 0 0 0 11.3872 0 0 0 0 A0A8C0MV93 A0A8C0MV93_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;LSDWIKKQDP;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.5 0.9892 -0.26514 10.6019 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MVB0 A0A8C0MVB0_CANLF Nuclear RNA export factor 2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ALKDVSYKIF;EPEEMEQLKLTMNKRYDV;LVSAYIHHCL;TVWRDRKNLKREVEEN;VLPYEKYKK;YERGGYEPQPSHLQE;YVLPYEKYK 7 13.3 0.99041 -0.2221 0 9.39827 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MVB1 A0A8C0MVB1_CANLF Sperm associated antigen 8 SPAG8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] axonemal A tubule inner sheath [GO:0160111]; male germ cell nucleus [GO:0001673] microtubule binding [GO:0008017] GVSNIKTLDTPFRKNCSFS;SVTHHDYRKE;WRRLGFEPVCVSRFSQDP 3 10.6 1.0015 -0.69384 0 10.3053 0 0 0 0 0 0 0 0 0 0 10.9763 0 0 A0A8C0MVB2 A0A8C0MVB2_CANLF CABIT domain-containing protein THEMIS2 Canis lupus familiaris (Dog) (Canis familiaris) GSIYEISGNECCLSTGD;KIPRHFMV;LPRNAKDSSNTYS;YFSGLRLEEKIME 4 8.6 0.9898 -0.22273 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5116 0 A0A8C0MVB4 A0A8C0MVB4_CANLF UBZ4-type domain-containing protein WRNIP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] AESSEGEGDDGDDGG;AGAAAAAAGSASPRSWGEAEAPDEE;EAPDEEDAAGDGDADGDADAD;GKGYKYNPMYSEPVDQ;PTDPLSHSSNSSSEPSV 5 13.5 0.78356 0.23204 0 0 0 7.16832 7.1267 0 0 9.10523 0 9.59837 0 0 0 9.33898 0 A0A8C0MVC6 A0A8C0MVC6_CANLF Sugar phosphate phosphatase (EC 2.1.1.-) (EC 3.1.3.-) ARMT1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein carboxyl O-methyltransferase activity [GO:0051998] ESKEQNFFESQ 1 2.5 0.981 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 8.73775 0 A0A8C0MVD9 A0A8C0MVD9_CANLF Family with sequence similarity 219 member B Canis lupus familiaris (Dog) (Canis familiaris) GERGPRRPGTSA;GGGGGGGD;GGGGGGGG;PMASSTCSCCWCCPG;SSTCSCCWCC;STCSCCWCCPGDSSSC 6 16.6 1.0021 -1.266 0 10.3311 0 0 0 0 0 0 3.60502 0 0 0 0 0 0 A0A8C0MVE4 A0A8C0MVE4_CANLF POM121 transmembrane nucleoporin C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASVRDGRGRGGGC;LMGSYLGK;SITAEDLDLEKRASLR;VGATAAWWGLSREPRGSR;VLSARNSKMVCSPV;YHKKTVLS 6 6.2 1.0038 -1.1041 0 0 13.1017 3.62515 0 0 0 0 0 8.55976 0 8.44878 9.29983 0 3.5918 A0A8C0MVE9 A0A8C0MVE9_CANLF BTB/POZ domain-containing protein 9 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; modulation of chemical synaptic transmission [GO:0050804] cytoplasm [GO:0005737] KNYDWDSGYTCHQ;TVRIFHCSFWIND 2 4.2 0.90151 0.12351 6.50743 6.7849 0 0 0 0 0 0 0 8.68461 0 0 0 0 0 A0A8C0MVF1 A0A8C0MVF1_CANLF N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) ACY1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520] cytoplasm [GO:0005737]; membrane [GO:0016020] aminoacylase activity [GO:0004046]; metal ion binding [GO:0046872] EEQLQGWCQAAGDGV;GHHQLRGFVPIAPA;LSGAAWSPP;TSWLWGGPNVT;VGLGGAGPATAHCASAPLWPRSPP 5 10.3 0.97386 0.041698 11.6416 10.8514 10.2648 0 0 10.0727 11.6204 10.7558 0 11.1485 12.7346 9.84917 11.1638 9.25974 10.381 A0A8C0MVF3 A0A8C0MVF3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HTVILSRNQGGLVAS;ISPGGTAAVGAVES;TLGRAGAFGAGPRGA 3 14.7 1.001 -0.64446 0 0 0 0 0 0 8.64965 0 11.4945 0 0 0 0 0 10.2165 A0A8C0MVF4 A0A8C0MVF4_CANLF Coiled-coil domain containing 18 CCDC18 Canis lupus familiaris (Dog) (Canis familiaris) DKLEQSQKMVIEKEQSLQKSQDEC;KLRQQNACLVSQNHSLMTKMESVHF;LEGTLEKSE;LRYINKEVRLLK;VQQLNEQL 5 5.7 1.0026 -1.7813 0 0 0 0 0 9.05726 0 9.11249 0 0 4.18404 6.1248 0 0 6.31602 A0A8C0MVH2 A0A8C0MVH2_CANLF 11-beta-hydroxysteroid dehydrogenase type 2 (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) Canis lupus familiaris (Dog) (Canis familiaris) steroid metabolic process [GO:0008202] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" ALLAAQPRRRYYPG;GGGAEGGH;LASLPRELLQA;RGGGAEGG 4 6.2 1.0033 -1.5658 11.1337 0 0 0 11.6858 10.4563 0 10.7686 0 0 12.0318 0 0 12.8747 0 A0A8C0MVH5 A0A8C0MVH5_CANLF 5'-nucleotidase NT5C3A Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737]; membrane [GO:0016020] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287] AGCFCCCA;DESLDVANSILQKI 2 4.3 1.0019 -1.364 0 0 0 0 0 0 0 0 0 0 2.77617 0 9.82489 0 0 A0A8C0MVK0 A0A8C0MVK0_CANLF Coiled-coil domain containing 85C Canis lupus familiaris (Dog) (Canis familiaris) adherens junction [GO:0005912] GAGGGGGG;GGGGGGGA;QDDNQELRELCCFLDDDRQK;VLEVHENLDRQLQ 4 11.2 0.92199 0.11544 0 0 0 0 0 0 7.09318 0 7.64659 0 0 0 0 0 0 A0A8C0MVL4 A0A8C0MVL4_CANLF Eukaryotic translation elongation factor 1 alpha 1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] DSKNDPPMEAPG;MMEPSANMPWF;VIGTVPVGQVETGV 3 14 0.98969 -0.19773 9.39945 0 0 0 0 0 0 0 0 4.71792 3.5208 0 0 0 0 A0A8C0MVN0 A0A8C0MVN0_CANLF Galactokinase 2 Canis lupus familiaris (Dog) (Canis familiaris) galactose metabolic process [GO:0006012] cytosol [GO:0005829] ATP binding [GO:0005524]; galactokinase activity [GO:0004335] GLVTLTVL;LVDGNIPPSSGLS;VDQLVDICRKFGAQGSRLT 3 9.4 1.0029 -1.3439 0 0 0 0 0 5.98028 0 0 0 0 0 0 8.25762 0 0 A0A8C0MVP9 A0A8C0MVP9_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] FITVSALFSHN;GTKPFECPVEDLFPQLG;GVAAGASDEALNSG;ISYPPRQQE;PGAGASPP 5 7.1 1.0025 -0.84284 0 0 0 0 0 9.82586 8.86861 9.98854 9.34944 0 0 0 2.04956 0 9.23972 A0A8C0MVQ0 A0A8C0MVQ0_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] AYHCSKCLEKVP;LVYVLYAVLV;RTHPHTQLHSLQTRTQSH 3 8.8 0.98374 -0.25658 0 9.21111 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MVQ4 A0A8C0MVQ4_CANLF "Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-)" IDO2 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441] cytoplasm [GO:0005737] "heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" VLHAFDEFLGICHSKE;VLSFLKSVRDKT 2 6.7 0.93533 0.099673 0 0 8.94962 0 4.30437 0 0 0 0 0 0 0 0 0 0 A0A8C0MVS2 A0A8C0MVS2_CANLF N-acetylglucosamine-1-phosphate transferase subunits alpha and beta GNPTAB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "calcium ion binding [GO:0005509]; transferase activity, transferring phosphorus-containing groups [GO:0016772]" CWSSDCEEMDMKE;FAFSYFYYLMSAIQPLNISQ;INCSKMLPANITQ;IRTLATRIHDLPLSLQDL;LPREYRNRFL;SSDCEEMDM;VLDPALPANVTLK;VLRDFYESMFPI;YSDNPIIRHA;YTDSYLGFLPWEKKKYFQ 10 10.4 1.0012 -0.74465 0 5.11819 0 0 0 5.08695 0 0 0 0 4.80823 0 0 0 0 A0A8C0MVS5 A0A8C0MVS5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178] beta-catenin binding [GO:0008013] ERGLNTPQK 1 4.6 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 9.71744 0 0 A0A8C0MVV6 A0A8C0MVV6_CANLF Mitochondrial S-adenosylmethionine carrier protein (Solute carrier family 25 member 26) SLC25A26 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020]; mitochondrion [GO:0005739] ITYEYVKWFLHTD;LVQFPMWESL;WRQDHVVDCWQS 3 8.2 0.99935 -0.61146 0 0 0 0 0 0 0 9.35275 0 0 0 0 0 0 0 A0A8C0MVX0 A0A8C0MVX0_CANLF Coiled-coil domain containing 171 CCDC171 Canis lupus familiaris (Dog) (Canis familiaris) AAIITSMAE;AALPADTVSVGD;CKNKSDTMKEL;EAKLKKKPFKGLIRIFRKGVIAILA;EHMDCSDLLRRQTSELEFSTQREE;EQWDAERRELQFIVQEQDNAVQ;IIQNCNREYDL;KKKPFKGLIRIFRKGV;LKKKPFKGLIRIFRKGVIAILAANR;RLHAAEVERRSL;SWTELCTVLQENV 11 10.7 0.99013 -0.19845 0 10.7028 6.26117 8.53535 10.6615 9.56482 3.39821 10.2422 0 5.76429 0 9.75072 13.7533 5.14466 7.69843 A0A8C0MVX4 A0A8C0MVX4_CANLF "Inositol 1,4,5-trisphosphate receptor" ITPR1 Canis lupus familiaris (Dog) (Canis familiaris) release of sequestered calcium ion into cytosol [GO:0051209] endoplasmic reticulum membrane [GO:0005789] "inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]" AADLEKKQNETENRKLL;DDYDSSGASKDEIK;DRDPQEQVTPVKYARLWSE;DVVCQRFP;ELLFPENTDARRKC;GGGGGGSG;LSPGGPSKP;PEVKIAYINFLNHCY;QYLAINEISGQLDVDLILR;RILYNMRPKEL;SEDLFNEMNWQKKL;SVNCNTSW;VLFMKWSD;VNSGEDVLVFY 14 6.3 1.0025 -1.7602 13.6184 9.05824 5.49025 7.67567 10.7935 0 11.0152 0 0 0 0 0 10.6978 3.57156 0 A0A8C0MVY0 A0A8C0MVY0_CANLF 8-oxoguanine DNA glycosylase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] damaged DNA binding [GO:0003684]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534] DNGWVGRPTPEELKTVHQYFQLDV;VLASGQSFRWREQDPAH 2 21 0.98396 -0.24238 0 0 0 12.9238 0 0 10.1765 0 0 0 0 0 0 0 0 A0A8C0MVY7 A0A8C0MVY7_CANLF Solute carrier family 13 member 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] solute:sodium symporter activity [GO:0015370] FFILMTVLWFTREPGFVPGWDSFF;RNLLLVIFVPLLLLPLPV;SGSKSSGL;VGGGYALAS 4 9.3 0.98619 -0.41377 0 0 0 0 0 0 0 7.29692 10.1555 0 8.76182 0 0 4.99702 0 A0A8C0MVZ4 A0A8C0MVZ4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; histone kinase activity [GO:0035173]; protein serine/threonine kinase activity [GO:0004674] LSGSLISE;SHMGKKRATGHDSCQ;SPGAAQMDCEEADG 3 4.7 1.0018 -1.2734 0 7.86245 0 0 0 4.59383 0 0 0 0 0 0 0 0 6.90881 A0A8C0MW05 A0A8C0MW05_CANLF Telomerase associated protein 1 TEP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGELLARYRQALETA;AKPESESSFLVAGADG;DEQKKFEDTYNA;DPAVFHMFLRQQV;FLGECRTWAPVLGSQVQ;IPEEETRRNRQLEVC;KSLVSGCDG;LYASSGPAEEQ;MSRNAKQDKTWT;NPNDVTLSGYSDGIL;PEPADQALKDKKLVLMS;PGAQPEEPAPTPEDNS;SEEKMPETELVE;TAHVLIAAQLWK;VCVSRRREAEGAAQ;VLSLENRCLAMLPD 16 8.2 0.93781 0.060873 0 8.02281 0 0 0 0 0 0 8.968 0 0 0 0 0 0 A0A8C0MW31 A0A8C0MW31_CANLF EGF-like domain-containing protein CCBE1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] VGSYRCEC;WRWDTRGASERSP 2 3.3 0.99119 -0.54702 0 0 0 0 10.2065 0 0 0 0 0 0 0 0 0 0 A0A8C0MW36 A0A8C0MW36_CANLF Enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2 Canis lupus familiaris (Dog) (Canis familiaris) histone H3K27 methyltransferase activity [GO:0046976] QVEKNHFHKI;VEKNHFHKIGGEGGNS 2 10.4 0.9905 -0.26708 0 0 0 0 0 7.75729 0 0 0 0 0 0 0 0 0 A0A8C0MW39 A0A8C0MW39_CANLF Aspartylglucosaminidase Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] KQEGSTYKETG;VGESATKFAKS 2 4.7 0.98461 -0.25884 0 0 0 8.08942 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MW44 A0A8C0MW44_CANLF Transmembrane protein 161B TMEM161B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLRLRLPRAL 1 2 0.99198 -0.2948 0 0 0 0 0 0 6.86678 0 0 0 0 0 0 0 0 A0A8C0MW52 A0A8C0MW52_CANLF Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; negative regulation of macromolecule biosynthetic process [GO:0010558] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] EDKEDDEEEEEEEED;EVPQDKDGYKSSG;FMWDCCCES;KGRKKIRKILK;KYVESDDEKPLDETVNED;LEQLLQQNKKKIKV;PNKLPKSKQSEIVDQNSDS;QCSSHHGALLNAYPPVTQSSP;SENDITMQ;SNSEEDKEDDEE;SSTSGSDYDI 11 8.7 0.96613 0.048586 0 0 0 0 0 0 0 0 0 0 0 0 8.63234 0 0 A0A8C0MW56 A0A8C0MW56_CANLF Protein S100-A11 (Calgizzarin) (S100 calcium-binding protein A11) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell population proliferation [GO:0042127] cytoplasm [GO:0005737]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; S100 protein binding [GO:0044548] CTRKSPRRGRTTPRPPCE 1 5 0.97373 0.048313 0 0 0 0 0 0 0 0 0 8.42957 0 0 0 0 0 A0A8C0MW76 A0A8C0MW76_CANLF Shroom family member 1 SHROOM1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; cell morphogenesis [GO:0000902] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; cortical actin cytoskeleton [GO:0030864]; microtubule [GO:0005874] actin filament binding [GO:0051015] ESGSAKLGDAYRP;ESGSAKLGDAYRPSGRS;GGGGGGGE;GGGGGGGG;PESPTSIYVSDQR;PGATAARADVGRGRLA;RDLERFSRF 7 7.8 1.0013 -0.64354 0 8.56902 0 0 0 6.60874 0 0 12.8881 1.77745 0 0 0 0 0 A0A8C0MW77 A0A8C0MW77_CANLF Phosphomannomutase (EC 5.4.2.8) PMM2 Canis lupus familiaris (Dog) (Canis familiaris) GDP-mannose biosynthetic process [GO:0009298] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615] GGHGPVGL 1 2.6 1.0039 -1.1044 0 0 0 0 0 0 10.4865 0 0 0 0 0 0 0 0 A0A8C0MW79 A0A8C0MW79_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] LSPPCSLG 1 4.5 1.0039 -1.1044 0 0 4.73709 0 0 0 0 0 0 0 0 4.72465 0 0 0 A0A8C0MW82 A0A8C0MW82_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] KAFRMKSYL 1 1.5 0.99021 -0.26166 0 0 0 0 0 0 0 0 0 0 0 0 13.4149 0 0 A0A8C0MW83 A0A8C0MW83_CANLF Creatine kinase B-type (EC 2.7.3.2) (Creatine kinase B chain) Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] MDQRLEQGQAIDD 1 8.6 0.93981 0.10321 0 0 0 0 0 0 13.6165 0 0 0 0 0 0 0 0 A0A8C0MW91 A0A8C0MW91_CANLF Spermatosis associated serine rich 2 like SPATS2L Canis lupus familiaris (Dog) (Canis familiaris) AARFSCDIEQLKAQIM 1 3.3 0.9512 0.053103 0 0 0 0 0 0 0 10.494 0 0 0 0 7.61353 0 0 A0A8C0MW96 A0A8C0MW96_CANLF Olfactory receptor family 56 subfamily A member 3E OR56A3E Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PSIITEQFVVKA 1 3.8 0.95394 0.05044 0 0 0 0 0 6.96751 0 0 0 0 0 0 0 0 0 A0A8C0MWA7 A0A8C0MWA7_CANLF Amino acid transporter transmembrane domain-containing protein SLC38A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVIGTFLDMDP;NLLIIIVSVLIILP 2 5.6 0.99232 -0.18388 0 0 8.64627 5.524 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MWD5 A0A8C0MWD5_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA stabilization [GO:0048255]; positive regulation of myotube differentiation [GO:0010831]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytosol [GO:0005829]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730] ISKQERKKKKKKK;KQERKKKKKKKGKERKEG;LISKQERKKKKKKKGK;QERKKKKKKKGKERKEGRKERKA;RKKKKKKKG;RKKKKKKKGKERK 6 4.2 0.72152 0.26292 0 8.46414 0 0 0 3.70454 0 0 0 0 5.03285 0 0 0 0 A0A8C0MWI2 A0A8C0MWI2_CANLF Fibrillin 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] CTDIDECEDNPNICDGGQ;DECREIPGVCENGV;DECSIMNGGCETFCTNSEGSY;EDMDECKEPDVC;EECTLPVAGRHRMDACCCSV;GCETFCTNSEGSYECSCQ;GYPPPPLG;IDECQRDP;MMTCEDINEC;NNDCIDVDEC;PVCESGCLNGGR;SCEDVDECEGNHRCQHG;TPGDFECKCDEGYE;TQHHTACIDNNE;VGRAWGHPCEMCPAQPH;VGSFQCQCNEGYE;VILEDIDE;YHCLCKNGYTPDITGTSC;YTSHGADANLEAGNV 19 9.3 0.95262 0.05044 0 0 0 0 0 0 7.29957 0 0 0 0 0 0 0 0 A0A8C0MWJ0 A0A8C0MWJ0_CANLF Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; GDP-mannose biosynthetic process [GO:0009298] mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270] EQGGGPRGLPGRA;PCLASAEEPSCPLCR;VRVPRGCGARPRKLTRRPRPP;WLRRGIQCLGSGL 4 11.7 0.98769 -0.35302 4.07365 0 0 0 0 0 0 0 0 12.3699 6.67356 9.19202 0 0 0 A0A8C0MWL0 A0A8C0MWL0_CANLF Transmembrane protein 161B TMEM161B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NGSLRWYQHPTEEELRILAGK;VLSFAVEIRKM 2 17.8 0.99132 -0.20553 0 8.56415 8.72352 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MWM9 A0A8C0MWM9_CANLF RRM domain-containing protein RBM28 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] EEDMEEEEEEEDDTEEEED;EPKHQELSKENGREEE;EQEDEDMQIS;FIRNLSFDSEEE;GVRLKECRVMRDLKGVH;LGRKLREIRLKSAST;QFKNLLEAGKALKS;REEEDMEEEEEEEDDTEE;RLCLHNLPKGVDDKELRKLLLNA;SEEQEDEDMQ;VEQVELPDGKKRRKVLVL 11 20.6 0.95058 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 5.71452 0 0 A0A8C0MWP5 A0A8C0MWP5_CANLF CWF21 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GGGGGGGA;GGGGGGGG;GPVDCDCPVAC;GPVDCDCPVACYRGHRG;KKKKKKGG;SVPSPTTGPAPH 6 7.9 1.0029 -0.73499 0 0 0 0 0 0 2.9991 0 0 0 0 8.98097 0 6.76527 0 A0A8C0MWR6 A0A8C0MWR6_CANLF "Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase)" MARS1 Canis lupus familiaris (Dog) (Canis familiaris) methionyl-tRNA aminoacylation [GO:0006431] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825] AGERNVLITSALPYVNNVPHL;QEICDKYHAIHADIYRW;VLQLDSGNYLFST 3 5.8 0.99542 -0.19016 0 9.89651 9.09595 0 0 0 9.89533 0 0 0 0 0 0 0 0 A0A8C0MWS5 A0A8C0MWS5_CANLF Nuclear receptor coactivator 2 (Transcriptional intermediary factor 2) NCOA2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983] AQMLAQRQR;EKHKILHRLLQDSSSP;FFFVVNLEGNVVFVSENV;KILHRLLQDSS;LGPSPKRSTE;LMSPRMAHTQ;LVISLHMLH;PSELEMNMGGPQ;SSESFTTRQDLQGKITSLDTSTM 9 6.8 1.0039 -1.1033 0 0 9.85837 0 7.39618 2.18793 11.4674 11.2747 13.2996 0 0 0 8.68152 8.49773 0 A0A8C0MWT1 A0A8C0MWT1_CANLF Transglutaminase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] ADYLHVTNIHLFKERWDTNKVDH;FNTFLRCLGIPA;VGFGGWQAVDSTPQE 3 7.2 0.97692 0.046419 0 0 0 0 6.22668 0 0 0 0 0 0 0 0 0 0 A0A8C0MWT3 A0A8C0MWT3_CANLF "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome oxidase assembly factor PET112 homolog) (PET112-like)" GATB PET112 PET112L Canis lupus familiaris (Dog) (Canis familiaris) glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] EEAATAVRELQ;ESPVTPSALAEL;ETREQLVQQYGM 3 6.1 0.98756 -0.46853 0 0 0 0 0 0 0 10.65 0 0 0 0 10.5339 0 0 A0A8C0MWU4 A0A8C0MWU4_CANLF LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) MESD Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] endoplasmic reticulum [GO:0005783] ANYDVQRFIVGSDRAIFMLRDG;DDDIEEGDLPEHK;VQEDNRAGN 3 18.8 0.53591 0.44078 0 0 0 0 0 5.38967 0 0 0 10.3235 4.75328 0 0 0 0 A0A8C0MWY2 A0A8C0MWY2_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) detection of stimulus involved in sensory perception [GO:0050906] calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; phosphoprotein phosphatase activity [GO:0004721] SLSEQLTKHEWE;TTDKSGNINYM;VLNKYQLKMLIRSHECKP 3 6.4 1.0025 -0.76168 0 0 9.78468 0 0 0 10.2987 0 0 0 0 0 0 0 0 A0A8C0MX04 A0A8C0MX04_CANLF Ankyrin repeat domain 55 ANKRD55 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] transcription cis-regulatory region binding [GO:0000976] GMTPLHWAAFHNRPQHTQ;VLKQRLQNSFQ 2 5 0.99036 -0.20511 0 0 0 0 0 0 0 0 0 0 0 0 0 9.665 0 A0A8C0MX05 A0A8C0MX05_CANLF Somatostatin receptor type 3 C1QTNF6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] somatostatin receptor activity [GO:0004994] ASGPHGYCQRCCDSESE;KGQAGSPG;NQFTSIFCLTVMSVDRYLAVVHPTR;RCCDSESEDPLAPADAADVS;SESEDPLAPADAAD;VSSASPPGLPYVLPE 6 12.1 0.98787 -0.48532 0 0 0 0 0 0 0 0 11.425 9.47385 9.03999 9.30549 11.125 8.7487 0 A0A8C0MX11 A0A8C0MX11_CANLF Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) CAND1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] cytoplasm [GO:0005737]; nucleus [GO:0005634] DADGGDDDDQGSDDEYSD;DDDQGSDDEYSDDDDM;DDEYSDDDDM;DEDEDENAMDADGGDDDDQ;DGGDDDDQGSDDEYSDDDD;DLNVRRVAL;DPNYNYDDEDED;ENAMDADGGDDDDQGSDDEYSD;FCNVDDDELREYCI;GGDDDDQGSDDEYSDDDDMS;IVDTLCTNMLSDKEQL;PVVACVGDPFY;QGSDDEYSDDDDM;SDDEYSDDD;SLTAAMIDAVLDE;VLGEGVPI;VPILASFLRKNQRAL;YDDEDEDENAMDADGGDDDDQGS;YNYDDEDEDEN 19 10.1 1.0021 -2.594 10.843 9.14091 5.62594 0 5.32175 9.17175 8.24712 7.60674 0 0 10.1605 3.93753 10.7565 5.30323 5.67107 A0A8C0MX19 A0A8C0MX19_CANLF Transmembrane 6 superfamily member 1 TM6SF1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] AALILLLVALLARVLVKRKPPR;GVAALILLLVALLARVLVKRK;GVAALILLLVALLARVLVKRKPPR;GVAALILLLVALLARVLVKRKPPRD;ILLLVALLARVLVKRKPPR;LILLLVALLARVLVK;LILLLVALLARVLVKRKPPR;LPQLLAYR;PYLNTAYGHMI;VAALILLLVALLARVLVK;VAALILLLVALLARVLVKRK;VALLARVLVKRK;VGVAALILLLVALLAR;VGVAALILLLVALLARVLVKRK;VGVAALILLLVALLARVLVKRKPP;VGVAALILLLVALLARVLVKRKPPR;VPGNIVGK 17 15.6 1.0018 -1.2496 15.7956 0 8.46915 8.68615 8.4477 9.41931 0 0 7.33441 10.7359 8.02862 8.68668 5.10635 8.02995 10.509 A0A8C0MX39 A0A8C0MX39_CANLF RAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitochondrial mRNA stability [GO:0044528] mitochondrion [GO:0005739] FSDLNSQNMFEAL;HVLFSLHA;IDIWKLKQVLFLLILFENLG;PRSAYCLDLGHPKG 4 8.4 1.0018 -0.91116 0 0 0 0 9.50329 0 0 0 0 0 0 0 12.637 0 0 A0A8C0MX41 A0A8C0MX41_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GSMGMSLNL;LPPSPAPPSLPF 2 4.8 0.95282 0.05044 0 0 0 0 2.6208 0 0 0 11.8045 0 2.9897 0 0 0 1.766 A0A8C0MX55 A0A8C0MX55_CANLF Flotillin FLOT2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; protein localization to plasma membrane [GO:0072659]; regulation of myoblast differentiation [GO:0045661] endosome [GO:0005768]; flotillin complex [GO:0016600] RWTESEHAL;SGGCCGSD;VEQIYQDRDQ 3 5.9 1.0033 -2.0877 0 5.54535 0 0 0 0 5.81842 6.14956 0 8.28457 0 0 5.52394 6.13284 0 A0A8C0MX59 A0A8C0MX59_CANLF HMG box domain-containing protein TOX2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] QLPTIQEMVHSE;QPMYAMPGLA;SEHSGPDWDRRW;SGASPASLARTLG;VLPTPMALQVQLAMSPSPPG 5 11.5 1.0023 -0.65884 9.22764 0 9.14149 0 0 0 0 3.89346 9.83545 0 0 10.3861 0 0 0 A0A8C0MX71 A0A8C0MX71_CANLF Serpin domain-containing protein SERPINA3 Canis lupus familiaris (Dog) (Canis familiaris) chromaffin granule [GO:0042583]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] TQEDLPNETSE;VGNAMFVG 2 4.5 1.0027 -1.1423 0 0 0 10.0954 5.94291 5.9986 0 0 0 0 0 0 0 0 0 A0A8C0MX76 A0A8C0MX76_CANLF DNA mismatch repair protein MSH2 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] MutSalpha complex [GO:0032301] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] AFKASPGNLSQFED;ESAAEVGFVRFF;FHELTALA;HVIECAKQKALEL;SELREIMDDLEKK;YLEREVCQI 6 7.8 1.0038 -1.6792 9.05967 0 10.7854 0 0 9.08186 0 0 9.67971 0 0 0 0 9.2684 0 A0A8C0MX96 A0A8C0MX96_CANLF UPAR/Ly6 domain-containing protein SLURP1 Canis lupus familiaris (Dog) (Canis familiaris) DLCNSVQASRLLGH;LVFCCFHDLCNS;PFHQSPMVTRSCSSSC;SSSCIATDPDSIGAAHLVFCCFH 4 43.4 0.98484 -0.44501 0 0 0 0 0 0 0 0 0 8.02525 0 0 9.79308 0 0 A0A8C0MXA4 A0A8C0MXA4_CANLF LON peptidase N-terminal domain and ring finger 3 LONRF3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DTDPQPEAATKG;VGLDPCHCLHQ 2 3.1 0.98214 -0.25115 0 0 0 0 5.54908 0 0 0 0 0 0 0 0 0 0 A0A8C0MXA8 A0A8C0MXA8_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) DWLMITVHRKTFRRKGECFVDHFFC 1 21.6 0.97481 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 7.41278 7.44659 A0A8C0MXB5 A0A8C0MXB5_CANLF FHF complex subunit HOOK-interacting protein 1B (FTS- and Hook-interacting protein) FHIP1B Canis lupus familiaris (Dog) (Canis familiaris) early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein transport [GO:0015031] FHF complex [GO:0070695] STPVLPPR;TAYLELFL;VARIGSNS 3 3.2 1.002 -1.2842 0 10.3298 0 0 0 0 10.1145 0 0 0 0 0 0 0 0 A0A8C0MXC3 A0A8C0MXC3_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] AAAGGDAGRAGGAAPSAAQQQQQ;ERCLFSYLDFLTQPW;ISDEGMIVIAKG;LEDSWFLPSL;LTTCWWDGGGGG;PENPCDCHRDPP;SLVTLLRPA;VADLPPCLTH 8 8.8 1.0026 -1.1995 10.0296 12.1191 13.1682 10.2814 0 10.2022 0 12.193 12.2477 7.14527 10.151 0 0 0 12.1587 A0A8C0MXG7 A0A8C0MXG7_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) platelet aggregation [GO:0070527] cytoplasm [GO:0005737] calcium ion binding [GO:0005509] SITLSSHASLN 1 6.5 0.98492 0.035491 0 0 10.0276 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MXH8 A0A8C0MXH8_CANLF Tubby-like protein TUB Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ATMQRKGVSSSM;DKKGMDRGMYP;EEEEEEDENSSSSSQ;EQKQKKKRQEPLMVQANA;LPSLHLAPCF 5 10.2 0.98725 -0.36442 0 5.62346 0 6.70598 0 9.00487 0 0 7.38879 0 0 0 0 9.26242 0 A0A8C0MXK5 A0A8C0MXK5_CANLF Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) Canis lupus familiaris (Dog) (Canis familiaris) BLOC-1 complex [GO:0031083]; transport vesicle [GO:0030133] EHRKAMERLKEQYAEMEKDLA;KNIIDNLVYNVI 2 18.5 0.99075 -0.19609 0 0 0 6.88142 0 0 0 8.84731 0 0 0 0 0 0 0 A0A8C0MXL0 A0A8C0MXL0_CANLF t-SNARE coiled-coil homology domain-containing protein STX11 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] ELTKSYDQQFPA;LNEIESRHREL;MGTMKDRLAE;NPCRTLCCFCCPC;QKTLDYTGQAKV 5 20 1.0026 -0.89951 0 0 0 0 0 0 7.13371 0 0 9.71492 0 4.83324 0 0 0 A0A8C0MXL3 A0A8C0MXL3_CANLF Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) SLC26A9 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transmembrane transport [GO:0098661] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] GGSIQVPQGMAFAL;IFAIISGILLVLVKELNARYMHKIR;QTNIASLIFAIISGILLVLVKEL;TNIASLIFAIISGILL 4 6 0.99658 -0.10046 9.43746 7.48599 0 5.29965 0 0 0 0 0 0 0 5.4444 0 0 0 A0A8C0MXL7 A0A8C0MXL7_CANLF WASH complex subunit 5 (WASH complex subunit strumpellin) WASHC5 Canis lupus familiaris (Dog) (Canis familiaris) WASH complex [GO:0071203] IDQLNTWY;IYFSAIAKTQKIWTAYLEAIMKVGQ;KLKELGATMDGFHRSFEYIQDYVN;LLKIIKLQTHDIIEV;LPKHMCLISFLMNSEQ;NIEIVTRFYLAFQ;RMTELADV;VEKNENLQAWF 8 10.8 1.0019 -2.6256 0 6.35122 0 8.06985 0 10.7535 9.17537 11.777 9.36036 0 0 0 7.07221 12.9521 0 A0A8C0MXL9 A0A8C0MXL9_CANLF PDZ GRASP-type domain-containing protein GORASP2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] EVSSAASSGELLPSLPPTGSP;GSPPSDPVTTTARADAASAPAP;HVLEVESN;HVLEVESNSPAALAGL;TPSNMWGGQGLLGV 5 15.8 0.086538 0.88714 13.3385 0 10.894 0 13.4389 13.4867 0 13.4647 13.2956 13.2348 0 13.3779 7.56423 10.9975 12.5998 A0A8C0MXN4 A0A8C0MXN4_CANLF Interferon alpha/beta receptor 2 IFNAR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SATPEDCMEPDAEEPDPSEPD;VLDDDLEVPPGLPSFPE;VWDYNYDDESDSND 3 10.1 0.85802 0.15416 0 0 0 0 0 0 0 0 7.54898 0 0 11.6561 0 0 7.43288 A0A8C0MXP4 A0A8C0MXP4_CANLF Tripartite motif containing 66 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ARYYQPWDKCEKLVLSLCCNSLSLP;GAKKGPPV;HLLCKNCFQGFIQEL;IVPPQDVQQ;KRVYLTRDVNEHFF;LTCSLCQQDLQNVG;QQGAHAQPTLQTPSIQ;VGQINYIVRQ;YQPWDKCEKLVLSLC 9 8.1 0.98462 -0.23938 0 0 0 0 0 11.1273 0 0 0 0 0 0 0 10.7684 0 A0A8C0MXP9 A0A8C0MXP9_CANLF HTH La-type RNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA stabilization [GO:0048255] RNA cap binding [GO:0000339] AHSLPTAVPESPRIHPV;EVEIVDEKMRK;EVEIVDEKMRKKIEPEKWPIP;LPMPWLGNCIQ;QEQEELDFLFDEEIEQIE;TDWSDNDSDY;VINDGLYYYEQDLWMGE 7 8.4 0.98923 -0.26301 10.4452 7.77452 9.75709 0 0 0 0 0 9.36221 0 0 0 0 12.9172 8.76898 A0A8C0MXQ2 A0A8C0MXQ2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESGGDLVKPG;EVPLVESGGDLVKPG;LVESGGDLVK;LVESGGDLVKPG;SGGDLVKPG;VESGGDLVKPG 6 10.4 0.060606 1.0122 0 0 0 9.17298 0 8.9208 0 0 0 9.16214 0 9.01346 0 0 0 A0A8C0MXQ3 A0A8C0MXQ3_CANLF Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; nucleus [GO:0005634] nuclear estrogen receptor activity [GO:0030284]; sequence-specific DNA binding [GO:0043565]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270] ADQMVSALLEAEPPV;GQQVPYYLENEP;KGNMAMES;QGKCVEGIVEIFDMLLATSSRFRMM 4 10 1.0043 -1.052 0 0 0 0 9.61237 0 0 10.4624 12.0846 0 0 0 0 0 0 A0A8C0MXS0 A0A8C0MXS0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVNGAHGE;GVRRKCTFQRLECLTNWICGML;PKRLQQAVGR 3 15.8 0.9877 -0.48446 0 9.0545 0 0 0 0 0 0 10.931 0 0 0 0 0 7.9384 A0A8C0MXS4 A0A8C0MXS4_CANLF Junctophilin Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; plasma membrane [GO:0005886] ELAPDFYQPGPEY;GGAYCGGW;KAGAKKRARKEA;KGQGEYSGSWNFG;NNGLQDGYGTETYADGGTYQG;PDSAPPSPAAAPEP 6 12.2 1.0024 -1.8696 0 0 0 9.15117 6.85599 0 8.72018 0 0 0 0 0 13.2323 0 0 A0A8C0MXT3 A0A8C0MXT3_CANLF Nuclear receptor subfamily 2 group F member 1 NR2F1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] GGGGGGGE;RTQACRGKEA;VAGGNPGG 3 5.3 1.0018 -1.4149 0 0 0 0 0 0 10.6629 0 10.6148 0 0 0 0 0 0 A0A8C0MXT9 A0A8C0MXT9_CANLF Secreted frizzled-related protein 2 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; non-canonical Wnt signaling pathway [GO:0035567] extracellular space [GO:0005615] Wnt-protein binding [GO:0017147] CIPLASSDHLLPATEEAPKVC;SLCVQVKDRCAPVM 2 12.6 0.99483 -0.15238 0 0 10.3225 0 0 0 0 12.5831 0 0 0 0 0 0 0 A0A8C0MXU1 A0A8C0MXU1_CANLF Plakophilin 4 PKP4 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] EIYERMVPPRPDSLTGLRSSYASQH;GVLWNLSSCDAVKMTI;KKKKKKKK;PELAQLRDH;VPPRPDSLTGLRSS 5 5.9 1.0041 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 10.0121 0 0 A0A8C0MXU6 A0A8C0MXU6_CANLF Golgin B1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; membrane [GO:0016020] AEMEEKISHILNLQKTEQE;AHAESLRQ;CVSELEEEKQQ;DESTKEILFNER;DIQLQFSEQST;DIQLQQKDEV;ELISTLKA;EQMSTKHQNRTSEEIPLN;IAFLKKKVV;LCHSRTRVPL;PHEESSLPTV;QQVTEISFSMTEKMVQ;RHLREELKQQ;RMEKSSWEAQERRI;RVLADNFKLKKELQSNKE;SLPDVYTEDTQAV;SLQDDRDRVI;TEQIHSLSIEA;TESQKDLE;TLESERSG;VLEKQVQELQ;VLQRKLEEHEEALL 22 8.1 0.99673 -7.732 0 0 10.0371 6.94918 9.58708 9.72439 11.0007 8.7741 10.2378 8.7766 10.11 8.23112 10.1392 8.9971 11.5553 A0A8C0MXV0 A0A8C0MXV0_CANLF Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) OXSR1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DEFDEESE;DGGWEWSDDEFDEES;EMLKKYGKSFR;LEKCQTSMDELLKEIQ;PISLVLRLRNSKKEL;PPPAEPAKTAQTLPS;WEWSDDEFDEESEEG 7 16 1.003 -0.85338 0 0 8.15618 0 0 8.18587 0 6.27867 0 6.6632 9.99435 4.98623 0 0 0 A0A8C0MXV4 A0A8C0MXV4_CANLF "FYVE, RhoGEF and PH domain containing 2" FGD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] LEPVQRIPRYELLLK;LLDQVFFQE;MKVRELTDAEF 3 5.8 0.99557 -0.19016 0 0 0 0 0 0 0 6.82706 0 0 0 0 0 0 0 A0A8C0MXV6 A0A8C0MXV6_CANLF Solute carrier family 22 member 13 SLC22A13 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fatty acid metabolic process [GO:0045922]; positive regulation of T cell mediated cytotoxicity directed against tumor cell target [GO:0002854] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794] nicotinate transmembrane transporter activity [GO:0090416]; urate transmembrane transporter activity [GO:0015143] FLSAFYMFAQVFMIQD;GAGLLCALLPE;PEHGPLSLQNEFNLVCDRKHLKETS;YMFAQVFMIQDEAHYCSVAW 4 11.1 0.9879 -0.47112 0 0 9.67034 0 8.84696 0 0 0 0 0 0 0 0 5.7483 0 A0A8C0MXW1 A0A8C0MXW1_CANLF "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type)" Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] DTDYLNMTRDCEH 1 3 0.983 -0.25564 0 0 0 0 0 0 13.0162 0 0 0 0 0 0 14.0436 0 A0A8C0MXW4 A0A8C0MXW4_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CTFMVMAY;ISFSACFFQMF 2 5.7 0.97994 0.035491 0 0 0 0 0 0 0 0 0 9.16672 0 0 0 0 0 A0A8C0MXX9 A0A8C0MXX9_CANLF Myelin-associated neurite-outgrowth inhibitor Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] APGVSRGPHGLGRV;PAYSPNMYPGANPTFQTGYTP 2 7.6 0.98384 -0.24231 0 0 0 0 0 0 0 6.42462 0 0 0 0 0 0 0 A0A8C0MXY3 A0A8C0MXY3_CANLF "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (GNT-I) (GlcNAc-T I) (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I)" Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] Golgi membrane [GO:0000139] "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]" GRDSFKAFAKALGVMDDLKSG 1 4.8 0.97711 0.047846 0 0 0 9.33856 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MXZ0 A0A8C0MXZ0_CANLF RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] ETIKSQDS;EVQLCTKAIKTSDI;LQEGQSGHSGKEVQLCTK 3 8.1 1.0034 -1.0335 0 0 0 0 0 0 9.84175 0 0 0 0 0 0 0 0 A0A8C0MY07 A0A8C0MY07_CANLF SUN domain-containing protein SUN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] WNTDQDEDQDPMEATDEEM 1 5.4 0.95197 0.04941 0 0 0 0 0 0 0 0 0 0 5.41545 0 0 0 0 A0A8C0MY09 A0A8C0MY09_CANLF Radial spoke head protein 9 homolog MAD2L1BP Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458]; regulation of exit from mitosis [GO:0007096] axoneme [GO:0005930]; kinocilium [GO:0060091]; motile cilium [GO:0031514]; nucleus [GO:0005634] ADLDPSLDFMDSLEHD;EETHAPQIELLETTSTQEPP;PSLDFMDSLEHD;SLLWPGLT 4 16.5 0.95019 0.05889 5.11815 10.2841 14.6373 13.5812 0 6.18706 11.2121 11.0173 10.9016 0 15.6366 0 10.2342 10.1383 14.8027 A0A8C0MY11 A0A8C0MY11_CANLF RRM domain-containing protein SLTM Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EQRLREHLVRFERLRRAMELRRRRE;FNDFDHRERGRFPES;IEKEDTESQEIEAQEGEDDTFLTAQ;LVRFERLRRAMEL;PESSTVQSSSFERRERFVGQSE;VQISGNSMPRGSG 6 9.8 0.98998 -0.3177 0 0 0 0 0 0 9.67895 10.2947 13.3757 0 0 0 4.47229 0 5.11091 A0A8C0MY72 A0A8C0MY72_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FTTFLMSSYLTAFSRRQVR 1 16.8 0.9842 -0.25293 0 0 0 0 11.4005 0 0 0 0 0 0 0 0 0 0 A0A8C0MY79 A0A8C0MY79_CANLF Tetratricopeptide repeat domain 7A TTC7A Canis lupus familiaris (Dog) (Canis familiaris) HPVDYELTYFLEAALQ;PTSHSVLYMRGRLAE;PTVPLMAAKVCIG;VINMAITEYP;VITCFERAS;VRQISSAIEQLQEALK;WDRMPELVRQLQALLGPGGGGG 7 12.9 0.99646 -0.57915 0 8.33981 0 9.64956 0 0 13.8768 13.8653 0 0 0 0 13.2461 0 0 A0A8C0MY89 A0A8C0MY89_CANLF 40S ribosomal protein S24 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] KKKKKKKK;SKKKKKKKKK;SLSKINSKKKKKKKK 3 9.6 0.95187 0.053874 0 0 0 0 0 0 3.54213 0 0 0 0 0 0 0 0 A0A8C0MYA3 A0A8C0MYA3_CANLF Disintegrin and metalloproteinase domain-containing protein 5-like Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] AVVLIKHKKIRE;DICYCSGECLQSG;FQLIFYISLPVLIITA;IPVYKQRQRR;ISLPVLIITAVVLIKHKKIR;NPENNVIEKYF;QLIFYISLPVLIITAVVLIKHKKIR;SLPVLIITAVVLIKHKKIRE;SYDDPDICYCSGE;VVLIKHKKI 10 9.7 1.002 -0.69266 0 4.47067 7.8421 0 8.34877 4.91614 8.68534 8.16672 3.69299 0 4.28429 0 6.84423 0 0 A0A8C0MYA6 A0A8C0MYA6_CANLF Zinc finger and BTB domain containing 10 Canis lupus familiaris (Dog) (Canis familiaris) AEGGSCSS;EEGYCDFNSRPNEN;GFSVILDFLYSGNLVLTSQN;GGGGGGGG;GGGGGGST;LSFIKEEPD;NSRPNENSYCYQLLRQL 7 9.1 0.99947 -2.8559 10.4276 0 0 0 9.49215 0 0 0 2.6769 0 0 0 0 8.71029 0 A0A8C0MYA7 A0A8C0MYA7_CANLF Paired box 4 PAX4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DITRQVSEGHPTPSL 1 4.3 0.95161 0.053901 0 0 0 0 0 0 0 9.39023 0 0 0 0 0 0 0 A0A8C0MYC6 A0A8C0MYC6_CANLF Stabilin 2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540] DNAATNGV;GPDCQPCRCSDHGQCDD;NACETSNGGCSS;NGVIHVISKVLIPRRSL;NVCFGNGICLDGVNGTGACECGP;SGDGSCDC;VGPQYTGQWQGVSRLQ 7 5.2 0.98837 0.02757 11.2102 0 0 0 0 0 0 0 0 0 0 0 0 0 11.0265 A0A8C0MYC7 A0A8C0MYC7_CANLF Delta-like protein Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509] CWASTPSACPDGAGADPAFT;DCASSPCANGGTCRDGV;GAPSSGAVRWAG;GVNEYSCTCPPGYTG;HYYGEGCSVFCRPRDDAFG;LAPGRRKPRRR;SRYCDQCI 7 9.8 1.0021 -1.2023 10.3793 14.1286 13.4294 0 0 0 0 13.5703 0 11.4644 14.1762 11.6495 13.392 0 13.6004 A0A8C0MYD5 A0A8C0MYD5_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] DVRLLDLGVLVV;LFNQHPDVFY 2 4.8 0.99247 -0.17645 0 0 0 0 0 5.49002 0 0 0 0 10.5425 0 0 0 0 A0A8C0MYF1 A0A8C0MYF1_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] AVLKFTTEIH;IGGVAVGIVLLLVLAGIGLFIH;KERERGRERRR 3 3.9 0.98963 -0.52927 0 0 0 0 8.67048 0 0 0 0 0 0 0 7.84235 0 0 A0A8C0MYF8 A0A8C0MYF8_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] actin binding [GO:0003779]; structural molecule activity [GO:0005198] AEPMKAFPPTAD;EKDYFGLTYRDA;PQEAAGAQGPVGAPQG;QKSSSSKLSRSPL;SLSASLDNDPSDSSEEETDSE;TETKTITYE;TETSHLAPSPQPLSTEK 7 7.5 0.99161 -0.0388 0 0 0 0 0 0 0 0 0 9.51623 0 0 0 0 0 A0A8C0MYH2 A0A8C0MYH2_CANLF Transmembrane protein 135 TMEM135 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane [GO:0031966] FFRCKDGLK;GFGAALPA 2 3.9 0.99684 -0.58887 0 0 0 0 0 0 0 0 9.49037 0 0 0 0 0 0 A0A8C0MYI0 A0A8C0MYI0_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEPGYLLTRVAAVDA;ASDCCLCCCCC;ASDCCLCCCCCG;ASDCCLCCCCCGG;ASDCCLCCCCCGGGGFACC;ASDCCLCCCCCGGGGFACCG;CCCCGGGG;CCCGGGGFACCG;CCLCCCCCGGGGFACC;CCLCCCCCGGGGFACCG;CLASDCCLCCCCCGG;CLCCCCCGGGGFACCG;DCCLCCCCC;DCCLCCCCCG;DCCLCCCCCGGGG;DCCLCCCCCGGGGF;DCCLCCCCCGGGGFACC;GGGGGGGE;GGGGGGGG;GGGGGGSG;LASDCCLCCCCCGG;LDSNDNVPAF;SDCCLCCCCC;SDCCLCCCCCG;SDCCLCCCCCGG;SDCCLCCCCCGGG;SDCCLCCCCCGGGGFAC;SDCCLCCCCCGGGGFACC;SDCCLCCCCCGGGGFACCG;SFKNYYTIVTEA;TCLASDCCLCCCCCGGGG;TCLASDCCLCCCCCGGGGFAC;TCLASDCCLCCCCCGGGGFACCG;VYVTENNVPG 34 9 1.0025 -1.1764 5.51586 8.08964 6.61356 7.52388 7.36054 0 5.80869 4.4889 6.07867 0 5.29602 8.39853 10.5197 7.70044 0 A0A8C0MYJ5 A0A8C0MYJ5_CANLF Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) ELOVL1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] fatty acid elongase activity [GO:0009922] GGRGGGGG;SFHAMINSSVHVVMYLYY 2 7.8 0.98375 -0.25538 10.3674 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MYK0 A0A8C0MYK0_CANLF Protein phosphatase 4 regulatory subunit 4 PPP4R4 Canis lupus familiaris (Dog) (Canis familiaris) HYVCPEGVTLWRRTLTVDSP;LPFLMRQNPAETLRRVL 2 26.2 0.9657 0.048405 0 0 0 0 0 0 0 0 0 0 0 0 0 6.72982 0 A0A8C0MYK8 A0A8C0MYK8_CANLF BAH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin binding [GO:0003682] CTPTGGPVLRGASSPG;DDNGSFEEEEEEEEEEEEAEEEPAA;EEEAEEEPAAASARS;EVEMRVRLAE;HHAVAYTVPSG;KAPFVGLG;LVEAAGLDSPS;PGEAAAPSLSPKAHDSP;PGTSPLDP;SLSPKAHDSPE;YLDPFSGS 11 4.6 1.0034 -2.2811 10.3656 10.6924 8.59119 0 0 6.26969 8.15659 0 10.4299 0 13.9165 10.3416 7.91755 0 0 A0A8C0MYL8 A0A8C0MYL8_CANLF Retinal dehydrogenase 2 (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) ALDH1A2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] aldehyde dehydrogenase (NAD+) activity [GO:0004029] TVKIPQKN 1 1.9 0.98226 -0.24859 0 0 0 7.67391 0 0 0 0 0 0 0 0 0 9.67359 0 A0A8C0MYR8 A0A8C0MYR8_CANLF NCK associated protein 1 like Canis lupus familiaris (Dog) (Canis familiaris) FLTLDMLESCFPYVLLRNAYREPEL;LKADTSSPEEEYKVACLLL 2 3.8 0.98521 -0.24517 0 7.69954 0 0 10.1616 0 0 0 0 0 0 0 0 0 0 A0A8C0MYS4 A0A8C0MYS4_CANLF CYRIA/CYRIB Rac1 binding domain-containing protein CYRIB Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of T cell activation [GO:0050870]; regulation of actin filament polymerization [GO:0030833] membrane [GO:0016020] small GTPase binding [GO:0031267] PPNSVEGLLNALSWPHSG 1 5.8 0.97325 0.048313 0 8.2151 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MYT0 A0A8C0MYT0_CANLF RDD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAAAGLGARAAHGQGAVRAAPAT;AYYSPFYFLGAA 2 8.9 0.99192 -0.27049 0 0 0 0 0 0 10.1936 0 0 0 0 0 0 0 0 A0A8C0MYT1 A0A8C0MYT1_CANLF adenylate cyclase (EC 4.6.1.1) IGFBP1 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] CHAEAVGP;EITQEQLLENFHLMVPSEEDTPIL;GGGGGGGA;GGGGGGGG;LAPAKRPRLW;LAVGFGLAVAASHLLIT;LDEINYQSYND;LDYLWTAQ;LLCCPLALGRPAGTPAGAAAGA;LVVLTPGG 10 10.7 1.0015 -2.6846 10.2863 0 0 0 0 9.10523 10.1441 0 0 10.9818 2.40594 0 0 9.86087 0 A0A8C0MYU0 A0A8C0MYU0_CANLF "Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LKLPEEPITRWGEYWCEVTVNGLD 1 9.8 0.97294 0.041303 0 0 0 0 0 7.60896 0 0 0 0 0 0 0 0 0 A0A8C0MYV0 A0A8C0MYV0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;ETRSTVEQ;MDAFLESHKL;MNEKGEITTNT;VLSPSLSNQ 5 6.9 1.0013 -0.92019 0 0 0 8.25375 11.7881 8.86437 0 0 0 0 0 0 0 0 0 A0A8C0MYV3 A0A8C0MYV3_CANLF Calcium binding protein 5 CABP5 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] calcium ion binding [GO:0005509] ELTELGQQIRM 1 6.4 0.98144 0.035491 0 0 0 0 0 0 8.19687 0 0 0 0 0 0 0 0 A0A8C0MYV4 A0A8C0MYV4_CANLF Sacsin molecular chaperone SACS Canis lupus familiaris (Dog) (Canis familiaris) DIFKELLQN;DTSYLIAMLGCNDI;ECTACIII;FLSFFPVNRLD;GAQDKLHLLEFVL;HITDVPCIFS;IQEIARSRKKDDPLKVGR;LVCNSVGGRGISGK;SPLPSAVL;TLKKFLSFFPVNRLD;TLLMDPMNVFYPGEY;VLRKSAHP 12 2.9 0.99903 -2.9693 8.57209 6.4418 0 9.88078 0 6.35191 12.3827 0 0 0 0 0 11.4951 0 11.193 A0A8C0MYV5 A0A8C0MYV5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;SAIRNDKYPPFALTWME;WFMYTMEYYSAIRNDKYPPFALT 6 5.4 0.93546 0.09248 0 0 0 0 0 0 0 8.30419 0 0 0 0 7.21111 0 0 A0A8C0MYW6 A0A8C0MYW6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] NLMQHDRIHT 1 1.4 0.99142 -0.14483 0 0 0 0 0 0 0 0 0 20.1219 0 0 0 0 0 A0A8C0MYZ0 A0A8C0MYZ0_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] SEIKALQQTRRLLANARE;SYSSISHVIY 2 8.9 0.99517 -0.56314 7.62256 0 0 0 0 0 4.35142 0 0 0 0 0 0 0 0 A0A8C0MYZ4 A0A8C0MYZ4_CANLF Amino acid transporter SLC1A1 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; neuron projection [GO:0043005]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202] cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872] FGTGIVEKLSKKELEQMDVS;LKLIILPL;LMISSSSATLPVTFRCA;MLDLIRNMFP 4 11.5 1.0021 -1.4604 0 0 10.5421 0 2.91888 0 0 0 0 0 0 0 10.6064 0 0 A0A8C0MZ04 A0A8C0MZ04_CANLF C2H2-type domain-containing protein ZNF674 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGGGGPAK;GHGPEFWQVDDQIDHHKKSQDRLL;HQRTHTGEKPYECCECTKAFSQK;RQRLPKYYSW;VFMQKANLVVHQRTH 5 13.7 1.002 -1.8021 0 0 0 7.1637 10.6214 0 8.98174 0 10.411 0 0 0 0 0 0 A0A8C0MZ14 A0A8C0MZ14_CANLF Tetratricopeptide repeat domain 21A TTC21A Canis lupus familiaris (Dog) (Canis familiaris) FIERTFMATSSY;GHYDKAREYIDCNLKLSNNSREGL;GVTWCQILEGHLEE;IDCNLKLSNN;KKEDVMETLNKAMDLQ;LHLKKILVVSRL;LSGELENAQSTLQRCLE;VGAPPAPRTAH;VMQDAINEFSGTPEEIRITIA 9 9.2 0.9891 0.035491 0 0 5.5787 0 0 6.1133 0 0 0 0 0 0 0 0 0 A0A8C0MZ18 A0A8C0MZ18_CANLF Secretory carrier-associated membrane protein (Secretory carrier membrane protein) SCAMP2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] membrane [GO:0016020] ELQSTVASLHVRENNWP;ERKERELQSTVASLHVRE;YYLWMLHSVTL 3 10.8 0.88172 0.13003 0 10.1158 0 0 0 0 0 0 10.6991 0 0 0 0 0 0 A0A8C0MZ29 A0A8C0MZ29_CANLF Little elongation complex subunit 1 Canis lupus familiaris (Dog) (Canis familiaris) AAEVPVSRSFPADN;AVLSCLEEVSSLCA;DKCRDGGTRQDAGV;GAEVMSELAEPSPQ;GGTRQDAGV;HHDDHVSNEGRHPE;IDKRKVKLLLK;LESCQLRDY;PKTEFQSSEKFG;RDGGTRQDAGV;SIDKRKVKLLLK;SRPLRDPPDWRGA;VGPPLPPLLAPLV;YAHDLHIPAQVSPLE 14 5.8 0.9876 -0.33918 11.1962 10.6715 11.3686 5.00441 0 0 7.0492 0 0 0 8.88996 17.2559 0 13.921 0 A0A8C0MZ46 A0A8C0MZ46_CANLF C2H2-type domain-containing protein ZNF276 Canis lupus familiaris (Dog) (Canis familiaris) CDQGHDYTMDADSSCGAL;DLVAWVHGHAASCGA;VCAGAGAA;VHMSMVHPLTQTQDK 4 7.4 0.9893 -0.26592 0 0 0 0 0 0 0 0 0 10.3773 10.4593 0 0 0 0 A0A8C0MZ51 A0A8C0MZ51_CANLF SUZ RNA-binding domain-containing SZRD1 Canis lupus familiaris (Dog) (Canis familiaris) QPEDSRQPNNVIRQP 1 11.4 0.9501 0.053907 0 0 0 0 0 0 7.9486 0 0 0 0 0 0 0 0 A0A8C0MZ75 A0A8C0MZ75_CANLF LDL receptor related protein 1 LRP1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] ADADCMDGSDEE;AGCSHSCS;AIALDPRDGILFW;CDADADCMDGSD;CDADADCMDGSDEE;CDADADCMDGSDEEAC;CDADADCMDGSDEEACGT;CDGDNDCQDNSDEAN;CDGDSDCEDNSDEENCE;CDGDTDCMDSSDEKSCEG;CDGEDDCG;CDGEDDCGDGSD;CDGEDDCGDGSDE;CDGEDDCGDGSDEPK;CDGEDDCGDNSDENP;CDGENDCHDQ;CDGNDDCGDGS;CDGNDDCGDGSDEGE;CDGSDDCGDGSD;CDNDNDCGDNSDEAG;CGDGTDEEDCE;CGDGTDEEDCEPPTAQTPHCKDKK;CGDHSDEPPDCPEFKCRPG;CMDSSDEKSCEGVTH;CNMFDDCGDGSDE;CNMFDDCGDGSDEEDC;CNQFVDCEDASDEMNC;CSARTCPPNQFSCASG;DADCMDGSDEEACGTGVRTCPL;DCADGADE;DDCGDGSDEEDC;DDCGDGSDEEDCS;DDCGDHSDEPPDCP;DERDCPEVTCA;DGDNDCQDNSDE;DGDNDCQDNSDEANCDIHV;DGDSDCEDNSDEENCESL;DGEDDCGDN;DGSDDCGDGSDEAAHCEGKTC;DGSDEPANCTQMTCGV;DNDCQDNSDEANCD;DNDNDCGDN;DTEDDCGDHSDEPPDCP;DTEDDCGDHSDEPPDCPEFKCRPGQ;DYDNDCGDNSDEESC;DYDNDCGDNSDEESCTP;ECDGENDCHDQS;EDDCGDHSDEPPDC;EHWTCDGDND;EKDIRTPNGLAIDHRAE;ENNRCIPNRWLCDGDNDCG;FDDCGDGSDEEDCSI;GADDCGDG;GDNDCGNSEDESN;GDNDCQDNSDEAN;GDSDCEDNSDEENCES;GKGRPGII;GWMYWTDWEEDP;ILIPLLLLLLLLLV;ITVHPEKGYLFWTE;KNDKCIPFWWKCDTEDDCGDH;LCDGNDDCGDG;LCDGNDDCGDGSDEGELCDQC;LCDGNDDCGDGSDEGELCDQCS;LCNGQDDCGDGSDE;LIPLLLLLLLLLVAGV;LIPLLLLLLLLLVAGVV;LLCNGQDDCGDGSDERACHVN;LLLLLLLL;LLLLLLLLL;LLLLLLLLLV;LSSRQWECDGENDCHDQSDE;MFDDCGDGSDEEDC;MFDDCGDGSDEEDCSID;PGHMASILIPLLLLLLLL;PGQFQCST;PLDKLCDGNDDCGDGSDE;PLLLLLLLLL;PNRWLCDGDNDCGNSEDE;QCDYDNDCGDNSDEE;RWKCDGEDDCGDGS;RWQCDYDNDCGDNSDEESCT;SCRGGRILQED;SDDCGDGSDEA;SDESPECEYPTCGPN;SILIPLLLLLLLLLV;SILIPLLLLLLLLLVAG;SILIPLLLLLLLLLVAGV;SLCYAPSWVCDGANDCGDYSD;SSRQWECDGENDCHDQSDEAPKNP;TCDKEDDCEHG;TLYGGEVYWTDWR;VCDRDNDCVDGSDEPANCT;VDWIAGNIYWTDQGFD;VGHCSNGGSCTMNS;VHPLRGKLYWTDG;VLSSNNMDMF;VPGRWQCDYDNDCGDNSDEES;WQCDYDNDCGDNSDEE;WQCDYDNDCGDNSDEESCT;WRCDNDNDCGDNSDEAGCSH;YFVDDIDDRIFVCNRNGD;YHNERLYWADA 103 15.5 0.99669 -8.6092 11.2384 10.0063 7.87732 9.90722 12.8742 13.2711 12.4698 12.4104 12.6597 10.1733 10.2719 10.8515 12.1246 12.9777 10.114 A0A8C0MZ80 A0A8C0MZ80_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CCPLHYATIL 1 3.5 0.99957 -0.61146 0 0 0 0 0 0 0 0 0 0 8.77498 0 0 0 0 A0A8C0MZ83 A0A8C0MZ83_CANLF Cyclic AMP-responsive element-binding protein 3-like protein 2 CREB3L2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FTHVTTSDSVNDDEVESEK;QQHLNDAI;VEVLENTN 3 6.8 0.9842 -0.24736 9.83646 10.0939 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZA2 A0A8C0MZA2_CANLF Kell metallo-endopeptidase KEL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EKTRKEAQNRVT;IDQLQEMAPAI;IEEIVREYLAYL;PLSNTPAFARHF;SHMILGLVR;VAPCTDFFSFAC;YKSCMDTGAIEAAGAA 7 12.4 0.99646 -0.57652 20.0916 20.037 20.1591 12.8075 18.8614 19.0505 19.9717 19.9555 19.9999 14.4307 20.2042 19.9051 20.1758 13.8899 14.0107 A0A8C0MZA6 A0A8C0MZA6_CANLF Ankyrin repeat domain 26 LOC607539 Canis lupus familiaris (Dog) (Canis familiaris) DVSNLKDNNEVLSQQLSK;ESELPENRES;QTEMDIQI;SETKEMKSQLEHQKVEWEQELCSLR;SNLKDNNEVLSQQLSKAESKFN;SRPSNNSIDTYLTKMQ;VEHLDDLTQ;VFLNGGKTEDEGEI;YAAAAAGL 9 7.2 0.99966 -2.8526 9.6876 0 0 0 0 0 0 4.27083 10.6775 0 0 10.6273 9.1642 6.8953 9.44518 A0A8C0MZB6 A0A8C0MZB6_CANLF MAM domain containing glycosylphosphatidylinositol anchor 1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; membrane [GO:0016020] EPSSQDVRQALGRPVLLRCSLLR;EVNISSETVPPTISV;GPAPPASPRGQRPRRRRNP;LEETPDGKLRLEH;LPPPLHRGASPGG;PGRRRRRRRRRLLGL;RGQRPRRRRNPG;SLIGPGGG 8 9.2 1.003 -1.3313 0 0 0 0 0 0 10.3953 8.2932 0 5.91853 0 9.71258 7.51554 10.6814 0 A0A8C0MZB7 A0A8C0MZB7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) LWKEPRCPWKDEWIKKMWFMYTME;MNEKGEITTNT 2 4.1 0.97417 0.041303 0 9.64703 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZC2 A0A8C0MZC2_CANLF Signal recognition particle 14 kDa protein (SRP14) Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942] VGVKEQKQWIIKP 1 10.3 0.93853 0.059565 0 0 0 0 0 0 0 7.1921 0 0 0 0 0 0 0 A0A8C0MZC3 A0A8C0MZC3_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; transferase activity [GO:0016740] CCTATGLHIICF 1 7.7 0.99085 -0.27479 0 0 0 0 0 0 0 0 0 0 0 11.7821 0 0 0 A0A8C0MZD0 A0A8C0MZD0_CANLF Mitochondrial carrier 1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] GAPGLGPV;GVGPAGPP;HGAQPPAA;PGLRGQRPD;VGLIPHLLGDVV;YLSVQVSK 6 9.3 0.99677 -5.1713 0 0 4.04072 0 7.65499 11.793 0 0 8.15325 0 0 0 8.02337 8.62655 0 A0A8C0MZE0 A0A8C0MZE0_CANLF "Sushi, nidogen and EGF like domains 1" Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] calcium ion binding [GO:0005509] DFVDRSRSSHQL;DSCASGPCHNGGTCFHYIGK;GRRYAIRAIALSGL;GVDTHSCDCS;GVYCETEVDAC;LCQAGYTGEACETDVDECASG;LTSEALHRVQ;MEYGGSYL;PGNCSENPCQ;PGRRYAIRAI;RRATEDVRRYFP;SPCDSDPCFNGGSCDAHEDTYTCE;TDVDECASGPCLNGGSC;VDTHSCDC 14 10 0.99719 -4.0264 0 0 13.5519 0 8.40131 7.90388 0 0 12.0272 8.89909 0 9.34671 0 0 7.79786 A0A8C0MZG5 A0A8C0MZG5_CANLF Attractin like 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAMGSWGP;GSGARCLQ;GVCWGESSFSWSSC 3 7 0.99045 -0.26822 0 0 0 0 8.35826 0 0 0 0 0 0 0 0 0 0 A0A8C0MZI3 A0A8C0MZI3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LFSYAVTRSCFWSLECLC 1 14.1 0.97211 0.048313 8.76597 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZI8 A0A8C0MZI8_CANLF "Helicase, POLQ like" HELQ Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] EAYSTGVL;IPFGVAYHHSGLTSDERKLLEEAYS;KQQIATNLDDIYHF;QSRHKDVFIEPEPDL;YDMASCCDPDWMIYFR 5 7.1 0.98764 -0.46123 0 0 6.57623 6.93015 9.98641 7.09677 0 7.94034 8.5378 7.05983 6.71905 0 0 10.2523 0 A0A8C0MZK4 A0A8C0MZK4_CANLF Maestro heat-like repeat family member 5 Canis lupus familiaris (Dog) (Canis familiaris) DEMCFLLQHTE;DIFIYMVE;DVGHPGRAT;GQFMHLNKMKNFEAK;IFKKYLEVL;LPSIVFKNIL;TVEVMLSLCHPSERQV 7 7.5 1.003 -2.1104 0 0 9.67548 0 9.09937 0 10.181 0 7.96353 0 0 0 0 0 12.5437 A0A8C0MZK6 A0A8C0MZK6_CANLF Zinc finger protein 541 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CCTASPSQ;ELALHCLHEAQGDV;ELWGGWSPVL;LDLGDIFSPG;LGLGVLKMPKEAD;PSREGCESAPG;QTKTVAQCVEYYY;SPGGPRQTQLGGEETLGAPLP;VPEEPRPPRKE 9 8 0.99918 -2.923 9.86601 0 7.44112 0 11.4804 9.27396 0 0 10.436 0 0 0 0 0 0 A0A8C0MZL3 A0A8C0MZL3_CANLF Zinc finger protein 569 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALHMRSHTGEKP;EEWQQLDPAQRNL 2 3.6 0.91544 0.11011 0 0 10.0699 0 8.6831 0 0 0 0 0 0 0 0 0 0 A0A8C0MZL5 A0A8C0MZL5_CANLF DNA primase (EC 2.7.7.-) PRIM1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-directed RNA polymerase complex [GO:0000428]; primosome complex [GO:1990077] DNA primase activity [GO:0003896]; metal ion binding [GO:0046872] IKNYFQHREFSFTLKD;QRWECLKKAISSQDI;WLELEIMLQYCFPRL 3 12 0.99179 -0.13859 0 0 9.88188 0 0 0 0 0 8.81855 0 0 0 8.25025 0 0 A0A8C0MZP2 A0A8C0MZP2_CANLF Protein phosphatase 1 regulatory subunit 7 PPP1R7 Canis lupus familiaris (Dog) (Canis familiaris) QEMMEEGQELPVDME;VLSMQSNRLTKMEGLQ 2 9.8 0.95121 0.053889 0 0 10.5554 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZQ0 A0A8C0MZQ0_CANLF "QKI, KH domain containing RNA binding" QKI Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; regulation of mRNA splicing, via spliceosome [GO:0048024]" nucleus [GO:0005634] mRNA binding [GO:0003729] EYPYTLAP;FNHLERLLDEE;IEPSGVLEWIEMPVMPDI 3 11.7 0.99199 -0.18212 11.6903 11.6623 0 0 0 0 0 0 6.91731 0 0 0 0 0 0 A0A8C0MZR2 A0A8C0MZR2_CANLF Plakophilin 4 PKP4 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] EIYERMVPPRPDSLTGLRSSYASQH;GVLWNLSSCDAVKMTI;HPYPLPEFDV;KKKKKKKK;QGHHPYPLP;QGHHPYPLPEFDVP;SNRKNFDAYRL;VPPRPDSLTGLRSS 8 6.8 1.0033 -2.1045 0 0 8.54982 0 0 9.20259 0 10.767 0 0 0 5.77152 0 12.5395 0 A0A8C0MZR3 A0A8C0MZR3_CANLF Protein CNPPD1 CNPPD1 Canis lupus familiaris (Dog) (Canis familiaris) cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; membrane [GO:0016020]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]; transmembrane transporter activity [GO:0022857] EWTWPLLTPRAL;MVASKYLYDEGEEE;VLSWLESCVAEQQGRRRGWYTYTDL 3 8.7 0.95238 0.05044 0 0 0 0 0 8.78202 0 0 0 0 0 0 0 0 0 A0A8C0MZT7 A0A8C0MZT7_CANLF GRAM domain-containing protein GRAMD4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane [GO:0016020] EKHFLQEELRKLREET;ERPLAVCENGWRCCLINRDRKM;GRFHGTKKGN 3 9 0.96319 0.049233 0 0 0 0 0 9.58301 0 0 0 0 0 0 0 0 0 A0A8C0MZU2 A0A8C0MZU2_CANLF Cyclin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] GRSRRRRRRRRRRRRPPRPA;RRRRRRRRRRRRPP 2 3.4 0.97424 0.048206 6.26457 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZU4 A0A8C0MZU4_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) YSIALTHVWEDV 1 8.7 0.94559 0.05044 9.24966 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZU7 A0A8C0MZU7_CANLF Glycoside hydrolase family 38 central domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GAEGGMRGSAWFLLQISPNSRLSQE;GAQFLYPAAQ;QARGGGGA;QEPRHSSACALP;VEEVLKTMVKNRDK 5 6.1 1.0043 -1.1044 0 12.146 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0MZV0 A0A8C0MZV0_CANLF Signal induced proliferation associated 1 like 3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] AHAPGGSG;IVRAHNPCTD;KFNLISLTSKKKEKTK;PSTVPTTGSNGFPEKKSTISAS;RPYRSNAPWQWS 5 3.9 1.0022 -1.4209 0 0 0 0 0 0 0 0 0 0 6.14441 6.91421 0 0 6.1022 A0A8C0MZV1 A0A8C0MZV1_CANLF RP9 pre-mRNA splicing factor RP9 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] DVPGNEHARE;EKHKKRKKDKKKKKKRKHKSSKS;HKKRKKDKKKKKKRKHKS;KDKKKKKKRKHK;KEKHKKRKKDKKKKKK;KHKKKKKKEKHKKRKKDKKKKKKRK;KKRKKDKKKKKKRKHKS 7 18.6 0.99899 -0.61146 0 0 0 0 0 0 0 0 4.36247 0 9.13722 0 0 0 0 A0A8C0MZW6 A0A8C0MZW6_CANLF Bombesin receptor activated protein C12H6orf89 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] EDTPKKFERFHP;GVKLTLWN;LFPVFTYLPFPKD;LPWYNPGPVF;LSGAHTWRSLIH;PKKFERFHPLVIKT;PLLIAIYKVLV 7 18.4 1.0023 -1.2385 0 0 0 0 0 0 0 9.69228 9.08242 6.34754 0 0 1.7111 0 8.47857 A0A8C0MZX6 A0A8C0MZX6_CANLF Serine incorporator 1 (Tumor differentially expressed protein 2) SERINC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ASLYIMMTLTNWYRYEPSREMKS;LRLLLGLSSF;QGNCVKYYF;SIRTSNNSQVNKL;SVITVYTMYLTWSAMTNEPE;VYCHYEDE;WYRYEPSREMKSQWT 7 20.9 1.0035 -2.0596 7.07082 0 9.37415 8.21252 7.20065 0 0 0 0 0 0 0 9.50855 12.8504 0 A0A8C0MZX9 A0A8C0MZX9_CANLF RNA helicase (EC 3.6.4.13) DHX38 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] DERDRSRHSSRSER;DILFSKTPQEDYVEAAVKQSLQ 2 2.9 0.99354 -0.14982 0 0 0 0 0 0 0 10.5719 10.785 0 0 0 0 0 0 A0A8C0MZY5 A0A8C0MZY5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DGLLPNSFYEASI;GVAILISDKLKFIPKT;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 6 10.2 0.92148 0.10895 9.85267 5.36005 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N018 A0A8C0N018_CANLF EP300 interacting inhibitor of differentiation 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEFDDWEDDYDYPE;DEFDDWEDDYDYPEEE;DEGDEFDDWEDDYDYPEEEQ;DFESEDEGDEFDDWEDDYDY;MPGEGDLPQMEVGGG;PDFESEDEGDEFDDWEDDYDY 6 21.5 0.73476 0.25358 8.14975 0 0 0 0 0 0 0 0 4.96384 0 0 0 0 5.18579 A0A8C0N034 A0A8C0N034_CANLF Spermatogenesis-associated protein 2 PUB-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] FSFLSLRR;PTVYQTQLDLYRDLQEDEG 2 6.4 0.9893 -0.21631 0 0 0 0 0 0 0 0 10.614 0 0 0 0 7.71143 0 A0A8C0N035 A0A8C0N035_CANLF Mitochondrial transcription rescue factor 1 MTRES1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DEESDREMSEREEELEDDPS;ESEKYRVVLRR;YRVVLRRWKKLKLPKKS 3 17.2 0.87753 0.12992 7.80858 0 7.30022 0 0 5.28292 0 0 3.89424 0 0 0 0 0 0 A0A8C0N039 A0A8C0N039_CANLF Interferon alpha inducible protein 27 like 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GRRQKKKRQGRWLGRRRLRVPESAD 1 9.7 0.99099 -0.29762 0 0 0 0 0 0 0 0 3.75307 8.40931 0 8.08066 0 0 0 A0A8C0N043 A0A8C0N043_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) DDX24 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] IEEVVSEGSAPTVPK;KKKKKKGKKKL;LVIKISLFH;PKKKKKKGKK;PQPQGDGTVYPDPEIEEVVS;VPKKKKKKG;VPKKKKKKGKKK 7 5.6 1.0017 -1.4138 0 0 3.56267 0 0 0 5.26375 0 0 11.6664 7.90773 0 0 0 5.36611 A0A8C0N057 A0A8C0N057_CANLF Phosphatidylinositol glycan anchor biosynthesis class Q Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] membrane [GO:0016020] GGWRLGGGRGPWGM;LSKRDLLLLVLGI;RLLVVAVQGLIH;VGTGGWGV 4 7.1 1.001 -0.93345 0 0 11.8031 0 0 4.93979 0 0 6.24806 0 3.42492 0 0 0 0 A0A8C0N059 A0A8C0N059_CANLF Sine oculis binding protein homolog Canis lupus familiaris (Dog) (Canis familiaris) IPHVNDSKPPNGFSSNGE;IVNGTRAAAAAAAAAAEGAKG;SLSPRDSKQGPSKPAD;SPPGFAGV;VPIPIPIPIPHVNDSK 5 16.9 0.97444 0.047166 0 4.88596 0 0 0 0 0 0 5.99747 0 0 0 0 0 0 A0A8C0N080 A0A8C0N080_CANLF GPN-loop GTPase (EC 3.6.5.-) LOC475707 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] LDEEDDEADSDTDDIDH;TLDEEDDEADSDTDD;VLGTGLDELFVQVTSAAEEYERY 3 11.1 0.97711 0.047532 0 0 0 0 0 0 0 0 10.6951 0 0 0 0 0 0 A0A8C0N0A8 A0A8C0N0A8_CANLF Cadherin EGF LAG seven-pass G-type receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ATQDVHFTENLLR;EVIQEQVQLTFSAG;EVRDVNAGPMRF;FITFRGLRQ;LEVIQEQVQLTFSAGE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PGPRSATAAVFLSVED;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPPPLLLLLLLLL;PPPPPPPLLLLLLLLLL;PTCGPCNCD;SEEEEEEEEEEAVFPG;SLSVGRPPGPGGGPPFLPSE;VTDTNDHD 19 4.7 0.98553 0.046227 0 0 0 0 0 0 0 0 0 0 0 7.48888 0 0 0 A0A8C0N0B9 A0A8C0N0B9_CANLF Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALLFDLSGFRSF;DLMYKQGRLQ;DLVETTRDV;EDKKIQLAKLEESLL;EVLEYMSRI;ISEIQDSPQ;KVLVFFKL;LSCASPAT;LVSEPWDQPL;NQVGDNRCLLQSLKDSPYYKG;NWIGDYFEKALQWVLKQVFN;PKAMPRHQ;QEVLEYMSRIDRVLSFPG;RLDFENRCRGVPGE;SEQKTELERLKHKIA;TLEELEPLLLPLKDEA;YSISKDIESCAQI 17 4.8 1.0029 -1.5841 0 9.68668 0 5.98709 0 9.9204 13.7987 10.5112 0 8.22757 9.89108 9.68897 9.48617 0 14.2371 A0A8C0N0D5 A0A8C0N0D5_CANLF Protein ZIP4 homolog Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] LHNILWKKAARSFEV;VGFYFMKIICEH 2 4.2 0.9893 -0.21617 0 0 0 0 3.68807 0 0 0 0 0 0 0 0 0 10.4928 A0A8C0N0E9 A0A8C0N0E9_CANLF SUN domain-containing protein SUN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] QDEDQDPMEEMSNLVNY 1 4.8 0.98368 0.046227 0 7.52034 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N0F9 A0A8C0N0F9_CANLF CABIT domain-containing protein THEMIS2 Canis lupus familiaris (Dog) (Canis familiaris) GSIYEISGNECCLSTGD;KDVGRTLYGFRFRQSNAHL;KIPRHFMV;LPRNAKDSSNTYS;SLPCEVKVVAKDSSHPAD 5 11.2 1.0023 -1.221 10.2657 0 0 0 0 0 11.1815 0 6.22292 0 9.64133 10.4442 0 0 7.42131 A0A8C0N0G1 A0A8C0N0G1_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] QPMDMLLGLDMLRRHQCSIDLKKN;TKLRMERN;VHLAQIQIEGDFLQC 3 11.6 0.98645 -0.4145 0 9.37751 0 0 0 0 0 0 0 0 0 0 0 10.3095 0 A0A8C0N0I2 A0A8C0N0I2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVLIATGCFIFLT;YGTLGMVYL 2 7.1 1.0029 -0.9833 0 0 0 0 0 0 0 0 0 9.51148 0 0 0 0 0 A0A8C0N0L7 A0A8C0N0L7_CANLF C2H2-type domain-containing protein ZNF423 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694] chromatin insulator sequence binding [GO:0043035] DDFMCDYCEDTFSQ;DESIYTCDHCQ;ENGTANGV;GEPECDRKTSRAL;LRDHNIRPGEDDGSRKKAEFI;RKLHKNHAYPVMQFGNIS;RNEDDEDMEDESIYTCDHCQQEFEC;VCESCDKQFSSVDDLQ;VVYSCPYC 9 9.5 0.98665 -0.41002 0 0 5.57247 11.8859 12.2039 0 0 10.7118 5.74036 0 0 0 13.25 0 10.0996 A0A8C0N0L8 A0A8C0N0L8_CANLF Ectodysplasin A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPTAAPRERGSQGC 1 9.4 0.98339 -0.25628 0 0 9.80384 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N0M5 A0A8C0N0M5_CANLF Midasin MDN1 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CLLLTSLRHLFG;DDEEEEEEEEDS;DEFVILLDPRWNMQALD;DEQERIAQEKAEQES;EASKGSAENGV;EDFSEQVETAIRAI;EDKNGGEDTDHEE;EHVHKRLKTVDMEN;ELLRRLPKLMKRMR;ELSYPSPVPRNQLPS;ESETGLLLKEKWEAFG;FRNFGVKLLQSTSGH;GELEEQEEDDGK;GLESIQIHLEASAA;HARLNAALAAPVKELGMSNVE;KAGHWVVL;KDEEASKGSAENGV;KFLIKKLSKIVR;KGPGEMPEIRSYM;LARKECLKFLIKKLSKIVRL;LDEISLADDSV;LDRGDTEPLV;LFLESSDANPVRYGR;LKEKWEAFGLRLNHAQQ;LPDLEKIMQS;MLEKHMQE;MLSRYSDLVLF;PAIDKNIVKKMVAF;PEARHCQPVL;PLDVVSVL;PQSLFSREN;QCQGAPFP;RIDHKGADIAEVML;SFVHAACLVYIDGIGSG;SVLRMSFEFHKDPESYHSLPHEIV;TEETGPGMDEEDC;VGALAKASGNILVR;VLDRLNALLE;VVQNLLKEE 39 8.7 0.99697 -5.9345 9.93581 15.8665 8.71156 0 8.37586 11.6546 13.2528 12.7664 14.3083 0 0 11.3699 10.7433 13.3778 7.02115 A0A8C0N0N2 A0A8C0N0N2_CANLF Protein tyrosine phosphatase receptor type N PTPRN Canis lupus familiaris (Dog) (Canis familiaris) secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] protein tyrosine phosphatase activity [GO:0004725] EPPPPTPSLPGYP;TDQKPLSL;YHVYEVNLVSEHIWCEDFLVR 3 4.7 1.0039 -1.0397 0 0 0 0 0 0 0 0 11.0053 0 0 0 7.67158 0 0 A0A8C0N0N4 A0A8C0N0N4_CANLF Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase II) PRPS2 Canis lupus familiaris (Dog) (Canis familiaris) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156] cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189] ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749] SDHDYFVGQWFSKWG 1 3.4 0.99587 -0.095347 0 0 0 0 10.8005 11.014 0 0 0 0 0 0 0 0 0 A0A8C0N0Q3 A0A8C0N0Q3_CANLF Large ribosomal subunit protein bL21m Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] AEETRHHAEVVGKV;AQTTCCCSCCCCC;AQTTCCCSCCCCCC;AQTTCCCSCCCCCCC;AQTTCCCSCCCCCCCFSR;AQTTCCCSCCCCCCCFSRAG;CCCCCCFSR;CCCCCCFSRAGFPPRQ;CCCSCCCCCCCFSRA;CCCSCCCCCCCFSRAG;CCCSCCCCCCCFSRAGFPP;CCSCCCCCCCFSR;CCSCCCCCCCFSRA;CCSCCCCCCCFSRAG;CCSCCCCCCCFSRAGFP;CSCCCCCCCFSR;CSCCCCCCCFSRAG;GGPKAQTTCCCSCCCCCCCF;GPKAQTTCCCSCCCCCCCFSRA;GPKAQTTCCCSCCCCCCCFSRAG;KAQTTCCCSCCCCCCCFSRAGF;PKAQTTCCCSCCCCCCCFS;QTTCCCSCCC;QTTCCCSCCCCCCC;QTTCCCSCCCCCCCF;QTTCCCSCCCCCCCFSR;QTTCCCSCCCCCCCFSRA;SCCCCCCCFSRAGF;SGGPKAQTTCCCSCCCCCC;TCCCSCCCC;TCCCSCCCCC;TCCCSCCCCCCCF;TCCCSCCCCCCCFS;TTCCCSCCCC;TTCCCSCCCCC;TTCCCSCCCCCC;TTCCCSCCCCCCCF;TTCCCSCCCCCCCFS;TTCCCSCCCCCCCFSRAGF;TTCCCSCCCCCCCFSRAGFP 40 8.8 1.0042 -2.0209 6.91121 9.75995 7.49649 7.06329 8.28137 5.51677 8.8913 6.77413 10.3596 6.78398 6.84449 8.20775 7.37721 5.69496 6.46244 A0A8C0N0Q7 A0A8C0N0Q7_CANLF Acid sphingomyelinase-like phosphodiesterase SMPDL3A Canis lupus familiaris (Dog) (Canis familiaris) sphingomyelin catabolic process [GO:0006685] extracellular space [GO:0005615] metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767] LSLDHISYKDC 1 2.6 0.98165 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.68159 A0A8C0N0W5 A0A8C0N0W5_CANLF Ceroid-lipofuscinosis neuronal protein 6 homolog CLN6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IITPFLLLKLIER 1 4.3 0.94156 0.05986 0 0 0 0 0 0 0 5.45404 0 0 0 0 0 0 0 A0A8C0N0Y8 A0A8C0N0Y8_CANLF Muscleblind like splicing regulator 1 MBNL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872] GSDTNCQYCTVE;VCREFQRGTCSRPDTEC;YHIGSDTNCQYCTVEPMFS 3 8.3 0.99295 -0.17867 0 8.73904 9.69223 0 0 5.32395 0 0 0 0 0 0 0 5.56252 0 A0A8C0N0Z5 A0A8C0N0Z5_CANLF Transcription factor RFX3 (Regulatory factor X 3) RFX3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MCNCDHGMYQ;SQHHQQFL 2 2.6 1.0004 -0.61287 0 0 0 0 0 4.97237 13.373 0 0 0 0 0 0 0 0 A0A8C0N102 A0A8C0N102_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] protein-disulfide reductase activity [GO:0015035] LCGVCGAG;SLSEKYSNVVFL 2 6.8 1.0043 -1.0539 0 0 5.72386 0 0 8.09191 0 0 0 0 0 0 0 0 0 A0A8C0N110 A0A8C0N110_CANLF 40S ribosomal protein S15a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] HTWKFSKADPLENH 1 10.7 0.93672 0.060945 0 0 0 0 0 0 5.42972 0 0 0 0 0 0 0 0 A0A8C0N118 A0A8C0N118_CANLF "Signal peptide, CUB domain and EGF like domain containing 2" Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] ALLLLLGLLLLLPPPPPTAAV;CDHFCKNTVGS;DVDECAQGLDDCHTNAICQ;GDTNECSVNNGGCQQVCVNTV;GEYSADGF;KAIRALRKAANRE;RDGRLYASENHQEILKDKKLIKA;RQCEDIDECENELNGGCV;TEKRLRKAIRALRKA;TIKRTEKRLRKAIRA;TIKRTEKRLRKAIRALR;VGSYECRC 12 14.7 1.0023 -0.65757 7.46499 0 0 6.33498 9.09769 10.2112 7.5292 5.28803 0 0 7.14456 8.23625 0 0 0 A0A8C0N122 A0A8C0N122_CANLF Ras-related protein Rab-4 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] early endosome membrane [GO:0031901]; insulin-responsive compartment [GO:0032593]; plasma membrane [GO:0005886]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ASPPLLLLLLLLLL;ASPPLLLLLLLLLLL;CRPQGPPLPLDF;GGRASPPLLLLLLLLLLLLAVGARP;GNAGTGKS;GRASPPLLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLA;LLLLLLLLLLLL;LLLLLLLLLLLLAVG;PGGGRASPPLLLLLLLLLL;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPLLLLLLLLLLL;PPLLLLLLLLLLLLAVGARPG;RASPPLLLLLLLLLLLLA;RASPPLLLLLLLLLLLLAV;SPPLLLLLLLLLLLLAV 23 10 0.99686 -0.087016 0 7.68356 0 3.66528 0 0 0 0 6.60971 0 5.72746 4.11137 0 0 0 A0A8C0N125 A0A8C0N125_CANLF Double PHD fingers 1 DPF1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] DFCLGGSKKTGCPED;GLPEGPVLEALLCAETGE;LSYHYTHTHLAEEEG;PSAGRTDPAGTCWG;RKHTAKKAPD;SLCGTSENDDQLLFCDDCDRGY 6 22.7 0.94142 0.061003 0 0 0 0 0 0 0 0 0 0 6.29668 0 0 0 0 A0A8C0N126 A0A8C0N126_CANLF Golgi apparatus membrane protein TVP23 homolog Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIQLIHGPTPSVPPG 1 4.3 0.99174 -0.14473 0 0 0 0 0 0 10.5466 0 0 0 0 0 0 0 0 A0A8C0N138 A0A8C0N138_CANLF Serum/glucocorticoid regulated kinase family member 3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine/threonine kinase activity [GO:0004674] KGSFGKVLLAKRKL;KHPFLVGL;VLLAKRKLDGKFYAVKQ 3 9.3 0.98329 0.046227 5.54831 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N139 A0A8C0N139_CANLF Pulmonary surfactant-associated protein B (Pulmonary surfactant-associated proteolipid SPL(Phe)) Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; respiratory gaseous exchange by respiratory system [GO:0007585] alveolar lamellar body [GO:0097208]; extracellular region [GO:0005576]; multivesicular body [GO:0005771] DLCQECQD;MPMRLTAGRERQQEPGS;QFVEQHMPRLQTLASGGRDA;WLCRTLIKRIQAMIPKGVL 4 13.8 1.0015 -0.95255 0 0 0 0 0 5.35804 8.7028 0 0 0 6.96451 0 0 0 0 A0A8C0N144 A0A8C0N144_CANLF CFA20 domain-containing protein WDR90 Canis lupus familiaris (Dog) (Canis familiaris) DELLVTLGDY;ELACVGQCAVTLWLLRGP;LDVATKDGQVVRMSFSNLFK;LEIDHQHMAVRHAR;PGAPPTCE;PGASSSAA;PGPVQESR;PLPEELGAGELTSLC;TRLVSGSNTRRLRL;VGSEDGYLRLWP;VPGGGPAP 11 7.5 1.0044 -1.1044 0 0 0 8.18334 0 0 0 0 0 0 8.52435 0 0 0 0 A0A8C0N146 A0A8C0N146_CANLF Phosphoserine phosphatase Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] FTATGALETEAGPSE 1 12.6 0.93926 0.063227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4372 A0A8C0N165 A0A8C0N165_CANLF "WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1" Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] CDGGGRGF;PLLLLLLLVL;RWAYSPLLQQCHPFVYGGC;SLHCDVSGRPPP;VPMLAPRPLLLLLLLVLGP;VYGGCEGNGNNFE 6 10.8 0.99353 -0.056967 0 0 0 8.49809 9.51385 7.96232 10.2576 10.3067 8.26543 0 0 0 0 0 0 A0A8C0N171 A0A8C0N171_CANLF Zinc finger SWIM-type containing 2 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EEPELFIPGTG;EISDLLQGIHRVQTPQKRTNG;MGPTGFLLREEE;VGKMSSQTFLPSIAHKNMVCSTGME 4 11.2 0.98516 -0.43678 8.84053 7.33083 0 0 0 9.7976 0 0 0 0 0 0 0 9.03232 0 A0A8C0N178 A0A8C0N178_CANLF SAM domain-containing protein PPFIBP2 Canis lupus familiaris (Dog) (Canis familiaris) DLSSTSSG;DRRIEELTGLLNQYRRVKEMMMAT;EEVAAGDGAAQPPPCSQD;EKREKMASPAYTPLTT;PLHRKKLILAVK;VGMEKEQREQEEKQRKAESVLN 6 11.2 1.0017 -1.8111 0 0 7.25323 8.93065 0 0 10.1478 0 2.83716 8.02026 0 0 11.6199 0 0 A0A8C0N186 A0A8C0N186_CANLF Tensin 3 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925] phosphoprotein phosphatase activity [GO:0004721] GVDPVYER;GVGPTPHLPDAQRPPPG;LDPQDRKWI;RTLTARGLTP;VIFCALDP 5 3.6 0.99877 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0484 0 A0A8C0N1A4 A0A8C0N1A4_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VLLFVKKII 1 4.5 1.0036 -0.80421 0 0 0 3.97801 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N1A6 A0A8C0N1A6_CANLF Kinesin-like protein KIFC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DSILVYLQKRT;SLRFASKVNQCVI;VPAQKPGAAAP 3 5.5 0.98387 0.035491 0 0 0 0 6.05087 0 0 0 0 0 0 0 0 0 0 A0A8C0N1C0 A0A8C0N1C0_CANLF Suppression of tumorigenicity 7 ST7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAAGWGGG;EVSVYPKKEL;GVDNNSSNNSNSSNGDSDS;KRVEGALNLLHCTWEGTFH;KYGTSFIEQVSVSHL;VLAKYDDIS 6 14.1 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 6.58814 0 0 A0A8C0N1C6 A0A8C0N1C6_CANLF C3H1-type domain-containing protein MBNL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] FAATATANQYIS;VCREFQRGTCSRPDTEC 2 7.5 0.99077 -0.20944 0 0 0 0 0 0 0 0 0 0 0 0 0 11.8172 0 A0A8C0N1D7 A0A8C0N1D7_CANLF WD repeat-containing protein 91 WDR91 Canis lupus familiaris (Dog) (Canis familiaris) early endosome to late endosome transport [GO:0045022]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898] early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902] phosphatidylinositol 3-kinase inhibitor activity [GO:0141039] EPFPELHVEALETLT;KKPEASVPEAEPFPELHV;QQLQFSLDPEPI;RLFAFDSEGNYMLTCSATGG;RTSAAGPEGGGV;VDKIVDQLQ 6 11.1 1.0018 -0.64824 6.64803 5.50118 0 11.1047 5.51507 6.90737 7.94895 0 10.8972 0 0 0 0 6.11559 0 A0A8C0N1E3 A0A8C0N1E3_CANLF Cullin 9 CUL9 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737] transferase activity [GO:0016740]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] AEDAASVAVEKGAGAP;CCMHYCCKSCW;DEEEEDDEDDVPE;EVDDEEEEDDEDDVPEWQQDEFD;FADRFLPDDEAAQA;GVGEGKTEHILMWLSAP;IDQLVCLVLEAWQ;IHEVPPPKSFAFLS;IVQELLYFL;LDDYEEVSAGDEGE;LEEEEEEAEEEEAEK;LETPGAPG;PIFQNLRENL;QLGYLTQAEWW;QSDSQLFNQLLVTE;RDTFFFGDEDDDDEAYD;RPDRSLREKLVKTLVELL;RPLLKRLQQ;SQWVDDGGYYDGMSVEAQSKH;WRAPDFVPRYCK 20 10.5 1.0027 -1.4893 10.3026 10.1839 9.29228 8.09982 8.40901 9.67659 10.2849 10.5221 10.6584 0 0 0 9.59727 0 9.92098 A0A8C0N1F1 A0A8C0N1F1_CANLF Solute carrier family 12 member 1 SLC12A1 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324] chloride:monoatomic cation symporter activity [GO:0015377]; potassium ion transmembrane transporter activity [GO:0015079] FRPQCIVLTGGPMTRPALLDITH;VILLVILLIAIAN;VIPSNNEKKSRGF 3 4.6 0.85114 0.16623 0 0 0 0 0 6.38786 4.16318 0 0 0 0 0 0 9.21099 3.07832 A0A8C0N1F4 A0A8C0N1F4_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] AGGGRGGQ;DRGSKMVSEIYL;FGFILDNVQSLLILN;GVRAPAGALRPSACPSGEAEP;HDEFVASMIKIPSDTFTVIPDFDI;LGEPFHKKE;QRRPRSLPPA;RESCGLCLKADP;SLRSRTPMITPDLESGVKMWH;VLFPGIEDHPVLRDLEVP 10 6 1.0018 -1.2908 7.1057 0 0 7.60763 0 0 0 13.5338 0 0 9.42387 0 9.20149 0 0 A0A8C0N1G8 A0A8C0N1G8_CANLF Sulfatase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787] ADAAQFIRRNAG;FHYCNFYLNAVRWHPRNSTSVWK;HFVSRHHPPLLFD;HYCNFYLNAVRW;KSCAAPGRGAQGL;LSPATEPRFR;MADDLGIGDPGCYGNT;NLRDCKPGEGSVFTRG;RLLLLLLL;VIQAGLVIDE;VLDELKLANNTLVYFTSDQGA 11 22.2 1.0014 -1.3139 9.67299 6.3821 10.2437 0 9.05066 9.93171 10.5078 0 0 0 14.0004 0 0 0 0 A0A8C0N1H6 A0A8C0N1H6_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; negative regulation of angiogenesis [GO:0016525]; regulation of establishment of cell polarity [GO:2000114] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] AAGGGHAE;LLQIVYGNY;QKKKRKKVLLE;VEHLPLAQGV 4 4.9 1.0018 -1.4678 0 0 0 3.84328 9.1047 6.77663 0 0 0 0 0 0 0 0 0 A0A8C0N1H9 A0A8C0N1H9_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MICOS complex [GO:0061617]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] ALQHASHR;CWLVPHPSPGQRGA;DRGSKMVSEIYL;EPQPGVRPVALEPGRAAARPLSSCH;IHCRSPSARE;KKHFLLTFIRTLEAQ;LLLPLLLLL;LLLPLLLLLL;LLLPLLLLLLLRGAQGAAGAPR;LLPPPPPLLLLPLLLLLLLRGA;LPPPPPLLLLPLLLLLLLR;LVKNHDHLDQREGDRGS;NSCLVYNDTTMV;PLLLLPLLLL;PLLLLPLLLLL;PLLLLPLLLLLLL;RESCGLCLKADP;RGGAGPGA;VLLPPPPPLLLLPLLLLLL;VLLPPPPPLLLLPLLLLLLL;VLLPPPPPLLLLPLLLLLLLRGA;VSVGGRPCS;YVYSFRSEQFVYYLTLQ 23 8.4 0.99686 -4.5151 5.61058 4.57307 5.87578 10.0676 7.74093 10.7232 10.756 0 11.934 4.42452 9.83253 10.8893 8.90138 7.70342 9.57607 A0A8C0N1I3 A0A8C0N1I3_CANLF mRNA-capping enzyme [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine mRNA capping [GO:0006370] nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; mRNA 5'-triphosphate monophosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] DIEEAPPPPLLPDWC;EDDDEEDEDEDGK;LPDWCFEDDDEEDEDED;VGAASVGG;VKMGLLVDL;WCFEDDDEEDE 6 7.4 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 5.46588 0 0 0 0 0 A0A8C0N1K7 A0A8C0N1K7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HAPIHPSTHP;QPTHPSTHPPIH 2 4.4 0.99654 -0.57961 0 0 0 0 0 0 9.18802 0 0 0 0 0 0 0 0 A0A8C0N1M4 A0A8C0N1M4_CANLF Pre-mRNA-splicing factor 38A PRPF38A Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U2-type precatalytic spliceosome [GO:0071005] DDVESSEEEEEE;ELMHVDEF;IYESKYWKEEC;MLGALYMRLTGTAIDCYKYLE 4 16.7 1.0018 -1.2532 0 0 0 9.84494 6.8009 0 0 0 0 0 0 0 8.17208 10.0052 0 A0A8C0N1M6 A0A8C0N1M6_CANLF Sidekick cell adhesion molecule 1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] DIVCRAMGVPLPTLQW;LDAGFYRCVVRNRMGALL;LLAGLRKFV;NQSIMVQWQPP;SKVVTVDVNGNWQRW;TATLRCGA;TSADTGLYVC;TTAGTGLA;TTYTSEYKYIIPSLQ;VGRGQYSAETSRL 10 5.8 0.99026 -0.26592 0 0 9.61445 0 0 0 0 0 0 0 0 0 9.63566 0 0 A0A8C0N1N5 A0A8C0N1N5_CANLF FA complementation group B Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ERKNGNSSEDHY 1 1.4 0.95358 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.1578 A0A8C0N1Q3 A0A8C0N1Q3_CANLF "Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687] DKAPNGTAGEGP;DPKEEPGPP;PEGKGDMGGGPAEGGVG;TETLNNVLSSNWYFDE;VLSSNWYFDEETF 5 9 1.0023 -0.65373 0 0 0 0 0 0 0 10.4633 7.53893 0 8.26045 8.17318 0 0 10.0473 A0A8C0N1R2 A0A8C0N1R2_CANLF ApaG domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) error-free translesion synthesis [GO:0070987] mitochondrial nucleoid [GO:0042645]; nucleus [GO:0005634] DNA binding [GO:0003677] AENPAGHG;EDILPYTSTDQVPIQ;KTHTYYQSQRSQTEAV 3 10.6 1.0014 -0.99651 0 0 0 8.9551 0 0 0 0 0 0 0 0 0 0 7.39609 A0A8C0N1T4 A0A8C0N1T4_CANLF NIPA like domain containing 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] CSSQQVLCQIVSDLS;RGDSSPGTVPSGARHSLHPWGRPGC 2 7.5 0.98948 -0.21717 0 0 0 0 0 0 0 7.47857 0 0 0 6.21352 0 0 0 A0A8C0N1U0 A0A8C0N1U0_CANLF Tripartite motif containing 34 TRIM34 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ITLNPSNL;SGKHYWEI;VLTISMAVP;VPPHRIGVFL 4 6.9 1.0007 -2.7432 0 0 0 0 7.05224 5.20504 0 0 0 12.2058 0 0 0 6.8416 0 A0A8C0N1W0 A0A8C0N1W0_CANLF WW domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] KQQGHEPVSPRSLQRSN;LPVFQLSRPE;PSTLPSSPFTL;QQPVTADKQQGH 4 6.6 1.0036 -1.0665 9.16325 0 0 0 0 0 0 8.81381 0 0 0 0 9.39004 0 8.19126 A0A8C0N1W7 A0A8C0N1W7_CANLF Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) Canis lupus familiaris (Dog) (Canis familiaris) autophagosome membrane [GO:0000421]; clathrin-coated vesicle membrane [GO:0030665]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; synaptic vesicle membrane [GO:0030672] signaling receptor activity [GO:0038023] EDSEQFRDASKILVDALQ;QMLRVLGNEFSILR 2 9.5 0.98993 -0.21572 0 0 0 4.36625 0 0 0 10.971 0 0 0 0 6.28046 0 0 A0A8C0N1Z1 A0A8C0N1Z1_CANLF Clarin 1 CLRN1 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] membrane [GO:0016020] QELDKFMGEM;VLSFVCALGVVT 2 9.5 0.98786 -0.48436 0 0 0 0 0 11.1191 0 0 0 0 0 0 0 0 0 A0A8C0N1Z2 A0A8C0N1Z2_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] peptidase activity [GO:0008233] VLSGRCRGQGRSPGP 1 4.5 0.99382 -0.073986 0 0 0 0 0 0 9.83083 0 0 0 0 0 0 0 0 A0A8C0N231 A0A8C0N231_CANLF Coiled-coil-helix-coiled-coil-helix domain containing 3 CHCHD3 Canis lupus familiaris (Dog) (Canis familiaris) MICOS complex [GO:0061617] VGSLPAQG 1 3 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 10.0658 0 0 A0A8C0N232 A0A8C0N232_CANLF t-SNARE coiled-coil homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DTETELERQDDVLDGITAAID;EVQFSKKMELL;GDDGQRGRQRGLRH;PAHQHHGARLLLRDRLLHR 4 9.4 0.98731 -0.39891 0 0 5.38045 4.09736 0 9.70895 0 0 0 0 9.981 0 0 0 0 A0A8C0N242 A0A8C0N242_CANLF Immortalization up-regulated protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] PGKAEKPKVKKKKEKKEKK 1 17.8 0.95378 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.91654 A0A8C0N245 A0A8C0N245_CANLF Tapasin (TAP-binding protein) TAPBP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LATVHLPYL 1 2.5 1.0043 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4126 A0A8C0N246 A0A8C0N246_CANLF Frizzled-4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813] DLSLRRLRLLLLLLLLL;DLSLRRLRLLLLLLLLLL;GEECHSVGTNSDQY;GGVDLSLRRLRLLLLLLLLLL;GVDLSLRRLRLLLLLLLLL;GVDLSLRRLRLLLLLLLLLLL;LLLLLLLE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLEP;LRRLRLLLLLLLLLLLE;LSLRRLRLLLLLLLLLLL;RLLLLLLL;RLLLLLLLL;RRLRLLLLLLLLLLL;SLRRLRLLLLLLLLL;SLRRLRLLLLLLLLLL;SVPGAPGGVDLSLRRLRLLLLLLLL;VDLSLRRLRLLLLL;VDLSLRRLRLLLLLL;VDLSLRRLRLLLLLLLLLL 23 8.1 1.0019 -0.67222 10.1914 0 8.12969 5.80131 8.15325 6.3404 0 6.60868 8.64108 4.79483 0 6.87615 9.73535 9.03626 0 A0A8C0N248 A0A8C0N248_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] IDNQKSTEE;VLESSPTECT 2 6.1 1.0032 -1.1135 0 0 0 0 0 0 0 0 0 0 8.26941 0 0 0 0 A0A8C0N288 A0A8C0N288_CANLF SWIM-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AKVKLVFVEDQ;GVTCSTPVGTALEGDPE;HVEKERGRGLQSGDWGG;PREPKRPCCPSAEE 4 6.4 0.99581 -0.11554 9.8112 0 4.29396 0 0 0 6.39895 0 0 0 0 0 0 0 0 A0A8C0N292 A0A8C0N292_CANLF Guanylate cyclase (EC 4.6.1.2) NPR2 Canis lupus familiaris (Dog) (Canis familiaris) cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; ossification [GO:0001503] plasma membrane [GO:0005886] ATP binding [GO:0005524]; phosphorus-oxygen lyase activity [GO:0016849]; protein kinase activity [GO:0004672] GSSYGSLMT;PSEIVQKVRN;VEERTQAYL 3 2.6 1.0041 -1.101 0 11.038 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N296 A0A8C0N296_CANLF NEDD4-binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] nucleolus [GO:0005730]; PML body [GO:0016605] RNA binding [GO:0003723] AIAVEYFWK;VCSSINELKTDSTPKKTQTQT;VEARADNY;VPDDPLGRSGPR 4 5.1 1.0029 -2.1129 0 10.0711 0 0 0 0 11.5869 0 0 0 0 0 0 0 0 A0A8C0N2A0 A0A8C0N2A0_CANLF Alpha/beta hydrolase fold-3 domain-containing protein AADACL2 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] LNRWTANKLD;VISTNYRLAPKYHFPNQFEDVY 2 6.3 0.98812 -0.50538 0 0 0 9.9857 0 0 0 10.83 0 0 0 0 0 0 0 A0A8C0N2C1 A0A8C0N2C1_CANLF "Polycystin 1 like 3, transient receptor potential channel interacting" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSESLVTLTSSV;LVCYCAFIQ;MQKVKVTVL;VISPLVDL 4 2.4 0.98968 -0.2632 0 0 13.3116 0 11.6261 0 0 0 0 0 0 0 0 0 0 A0A8C0N2C3 A0A8C0N2C3_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IILAISLHSHLHT;LLLLLSWLIC;LVNIQTRTNTIT 3 10.4 0.98993 -0.21231 3.47625 0 0 0 0 7.52521 0 0 0 0 0 0 0 0 0 A0A8C0N2C7 A0A8C0N2C7_CANLF NEDD8-activating enzyme E1 regulatory subunit NAE1 Canis lupus familiaris (Dog) (Canis familiaris) protein neddylation [GO:0045116] cytoplasm [GO:0005737] NEDD8 activating enzyme activity [GO:0019781] MNVPQIKKKLWG 1 2.3 0.98789 -0.26453 0 0 0 0 0 0 0 10.6282 0 0 0 0 0 0 0 A0A8C0N2E0 A0A8C0N2E0_CANLF C2H2-type domain-containing protein LOC488951 Canis lupus familiaris (Dog) (Canis familiaris) IIHTGLKPYECYE;SQKSNLIVHQRTHTGE;VGNKPYECNACGKTFYHKSV;YRKSDLAKHQRSHTGE 4 9.2 0.98966 -0.21547 0 0 0 8.85122 9.18205 9.42978 0 7.15086 0 0 0 0 0 0 0 A0A8C0N2E7 A0A8C0N2E7_CANLF HID1 domain containing Canis lupus familiaris (Dog) (Canis familiaris) EAGVGFAHSP;GGGGSGSSLVHP;IDKGLTDESEI;PTDPPAIH;WFRTYMWGVIYLRNV 5 6.3 1.0043 -0.81776 9.69061 8.25578 4.06678 0 0 0 10.5311 0 0 4.03589 5.36971 0 4.94991 10.4124 0 A0A8C0N2F2 A0A8C0N2F2_CANLF Cullin 9 CUL9 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737] transferase activity [GO:0016740]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] AEDAASVAVEKGAGAP;AVGNLISELPCISGP;CCMHYCCKSCW;DEEEEDDEDDVPE;EVDDEEEEDDEDDVPEWQQDEFD;FADRFLPDDEAAQA;IDQLVCLVLEAWQ;IHEVPPPKSFAFLS;IVQELLYFL;LDDYEEVSAGDEGE;LEEEEEEAEEEEAEK;LETPGAPG;PIFQNLRENL;QLGYLTQAEWW;QSDSQLFNQLLVTE;RDTFFFGDEDDDDEAYD;RPDRSLREKLVKTLVELL;RPLLKRLQQ;SQWVDDGGYYDGMSVEAQSKH;WRAPDFVPRYCK 20 11.6 0.94942 0.053891 0 0 0 0 0 6.53753 0 0 0 0 0 0 0 0 0 A0A8C0N2G5 A0A8C0N2G5_CANLF Zinc ribbon domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) PSGSRPAPQPPVPRPEHCEG 1 12.3 0.95108 0.053689 8.74413 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N2G7 A0A8C0N2G7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CSNK1G2 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HSGHPALRPSRPPAEEKRG 1 3.9 0.95347 0.049524 0 0 0 0 0 0 8.19081 0 0 0 0 0 0 0 0 A0A8C0N2H4 A0A8C0N2H4_CANLF NADPH oxidase 4 NOX4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] oxidoreductase activity [GO:0016491] VTICIFSGVHVA 1 3.5 0.9567 0.05044 0 0 7.32175 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N2H9 A0A8C0N2H9_CANLF Olfactory receptor OR2V1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PALLKLACTDTSLFDTL;VSLVGSEGLLLGLMAYDRY;YDRYVAISHPLHYPILM 3 15.6 0.86169 0.14566 9.32827 0 0 6.4417 0 0 0 10.6398 0 0 0 0 0 0 0 A0A8C0N2I0 A0A8C0N2I0_CANLF PR domain zinc finger protein 1 (EC 2.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) cell fate commitment [GO:0045165]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DVTSVVEKE;GGGGGGGG;HPWDCGADGGASVQAEASLPR;MGIKGLLPPTPPFSL;SPLAPCGP 5 8.5 1.0018 -1.2844 0 6.53636 0 0 0 0 7.94275 0 0 0 10.5814 0 0 0 0 A0A8C0N2I8 A0A8C0N2I8_CANLF UDP-glucose glycoprotein glucosyltransferase 1 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum lumen [GO:0005788] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980] AQPKGDARIEYQ;QEWLWCETWCDD;TIENESGFWDSFKWGF;VLDKEKTTQ;VLDSQGKT;VNDSEDVDGMQDAGV 6 5.1 1.002 -1.4367 0 0 9.23609 9.05775 0 0 0 0 7.8711 9.80545 11.6819 0 0 0 11.0203 A0A8C0N2J0 A0A8C0N2J0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;KTVWYWHKNRHIDQWNGIENPEVDP;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 5.7 0.97385 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 9.04862 0 A0A8C0N2J5 A0A8C0N2J5_CANLF Myeloperoxidase MPO Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] membrane [GO:0016020] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] GLRGQERGMGGLS;LTPDQERSLLFMQWGQ 2 3.9 0.9876 -0.4817 0 0 0 0 0 0 0 10.1635 0 0 0 8.34359 0 0 0 A0A8C0N2K1 A0A8C0N2K1_CANLF Endothelial PAS domain protein 1 EPAS1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] AEANQQMDNLYLKALEGFIAVVTQD;DLSGGDPPGS;EAEANQQMDNLYL;EANQQMDN;EVIEKLFTMD;LDFGSQSF 6 6.4 1.0034 -2.2153 8.82158 0 0 0 10.9291 8.90298 0 10.7243 0 0 0 0 0 0 0 A0A8C0N2K8 A0A8C0N2K8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;QTILKTYYEPQYA 5 7.2 0.99001 -0.26342 0 0 9.91322 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N2L6 A0A8C0N2L6_CANLF Phorbol-12-myristate-13-acetate-induced protein 1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; release of cytochrome c from mitochondria [GO:0001836] CGAGGSTGPGRSPR;GEGRGCGA;SPLPRPYTHTHTHTHSHT 3 9 1.0018 -0.99497 0 0 0 8.33136 0 7.61699 7.32499 0 7.15856 0 5.39849 0 0 0 0 A0A8C0N2N3 A0A8C0N2N3_CANLF Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] EEEGAPSPWAMGV;PFPREGGEEKGRSMSSQ;VLSVLVLLLLAVLMRRRQLRPRCRH;VLVLLLLAVLMRRRQLR;VPAAVFMVLFSS 5 7.8 0.99106 -0.29656 0 0 0 0 11.7259 7.57478 0 0 0 7.82515 0 0 0 5.93993 0 A0A8C0N2P8 A0A8C0N2P8_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) CREB3L2 Canis lupus familiaris (Dog) (Canis familiaris) "diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]" nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] CRMYIDRLQ;FTHVTTSDSVNDDEVESEK;GSQRVHYQDHETSFPRALSAQRLSP;KRGTEQENKGRP;LDATSADRFYRIDRSQEHLHFVMEI;VEVLENTN 6 8.2 1.0007 -0.63482 0 10.0972 10.5579 0 0 0 0 0 0 0 0 0 0 0 7.03661 A0A8C0N2R8 A0A8C0N2R8_CANLF Protein tyrosine phosphatase non-receptor type 11 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERK1 and ERK2 cascade [GO:0070374] cytoplasm [GO:0005737] cell adhesion molecule binding [GO:0050839]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; receptor tyrosine kinase binding [GO:0030971] KQGFWEEFETLQQQECKLLYSRKE;KVKQGFWEEFETLQQQECKLLYSR 2 6.2 0.94724 0.082605 0 0 0 0 0 0 0 11.1916 0 0 0 0 0 0 0 A0A8C0N2S5 A0A8C0N2S5_CANLF Suppressor of cytokine signaling 1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein ubiquitination [GO:0016567] phosphatidylinositol 3-kinase complex [GO:0005942] 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] APARARPCAPPA;GACGAGPA;LEHYVAAP;PEGSGPGA;SFDCLFELLEHY 5 8.4 1.0027 -2.5736 0 12.515 12.8406 0 0 0 0 0 10.2218 0 0 9.42173 0 0 0 A0A8C0N2T3 A0A8C0N2T3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) LFADDMILYIENPKDSTLRLLE 1 3.2 0.97645 0.047355 0 6.14549 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N2V4 A0A8C0N2V4_CANLF FRA10A associated CGG repeat 1 Canis lupus familiaris (Dog) (Canis familiaris) HSSSKKSESCVNKKKN;SNKRKKRTIEDDLLLKKPF 2 11.7 0.95477 0.050696 0 0 0 4.63998 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N2V8 A0A8C0N2V8_CANLF Mediator complex subunit 12L MED12L Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] beta-catenin binding [GO:0008013]; transcription coregulator activity [GO:0003712] AISEAKIKKRQ;EDELTAVNVK;EPGARMTCR;HSCLILNP;ILSNWREERYQDDIKARQMMHEAL;KVEFVNLVLLFCEF;PGESCENANPSLGR;SELTACCTVLSSEW;VEVRWSFDKCQE;VGKERDEARHQLKKITKDILKILN 10 7.7 1.0012 -2.7149 9.54444 0 0 0 0 7.15896 12.9096 12.4597 0 10.1504 0 8.09445 0 0 9.43605 A0A8C0N2V9 A0A8C0N2V9_CANLF Osteoclastogenesis associated transmembrane protein 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ARRRSLLLLVLLL;ARRRSLLLLVLLLLLW;KKRKLILPKRLKS;LFNHTLTCFEHNLQ;LVLLLLLW;RRSLLLLVLLLLLWSGALAL;TVPVIAVSVF 7 18 1.0013 -0.94739 0 0 0 0 0 0 6.39053 4.10274 0 0 0 5.9816 0 5.6794 0 A0A8C0N2W3 A0A8C0N2W3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLFPSETTVKSE;FLFPSETTVKSEEVDK;LASSKNIL;VFLNGGKTEDEGEI 4 13.9 0.98661 -0.45716 0 0 0 0 9.03403 0 0 0 0 0 8.77251 0 0 0 0 A0A8C0N2W5 A0A8C0N2W5_CANLF F-box domain-containing protein FBXW7 Canis lupus familiaris (Dog) (Canis familiaris) EDEEEEEMDQE;EEDEEEEEMDQESDDFDQS;EEEEEMDQESDDFDQ;IVSGSDDNTLKVWSAV;MMQVIEPQFQRD;QDEEDEEEEEMDQESDDFDQSDDS;SMCGCGCS;STCCSDLFSC;VGAEPRPGDQNDS 9 10.6 1.0038 -1.9718 6.14608 9.70422 4.07082 0 11.4169 4.5995 7.92535 9.5955 9.5113 0 9.83191 9.64283 5.01988 4.45108 0 A0A8C0N2Y1 A0A8C0N2Y1_CANLF phospholipase A2 (EC 3.1.1.4) PLA2G6 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] calcium-independent phospholipase A2 activity [GO:0047499] LIRNHPSWSAA;LVNFQQYSSQLPPFY;QYFRLNPQLGTDIMLDEV;TLLRTVGADYRLPLT 4 7.1 1.0026 -0.71921 0 0 0 9.37593 0 11.1974 0 0 0 0 0 0 9.66667 0 0 A0A8C0N2Y5 A0A8C0N2Y5_CANLF adenylate cyclase (EC 4.6.1.1) IGFBP1 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] ATGPPPVAPMAGLPVRAGLGALQG;GGGGGGGA;GGGGGGGG;LAPAKRPRLW;LAVGFGLAVAASHLLIT;LDEINYQSYND;LDYLWTAQ;LLCCPLALGRPAGTPAGAAAGA;LVVLTPGG 9 10.6 0.97386 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 4.35776 0 0 A0A8C0N2Y7 A0A8C0N2Y7_CANLF Arf-GAP domain-containing protein ARFGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] LSFVRSVTMDKW;TLLSAAHRFCRKRPCW;VVPSFVLPST 3 7.6 0.99434 -0.56222 0 0 0 0 0 0 0 10.7549 0 0 0 0 9.65825 0 0 A0A8C0N2Z0 A0A8C0N2Z0_CANLF "ArfGAP with SH3 domain, ankyrin repeat and PH domain 1" ASAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] CCDCGSSE;DLKGVKGD;EITGAEIA;GSAKTALGPRVLPKLPQKV;KPTELAPKPQI;LDIAKRLKATQCEDLL;LLPESIPNSPPPLSHPWMPDQI;VLPKLPQKVAL 8 8.1 0.9848 -0.25747 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4175 0 A0A8C0N2Z3 A0A8C0N2Z3_CANLF Voltage-dependent L-type calcium channel subunit beta-2 (Calcium channel voltage-dependent subunit beta 2) CACNB2 Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] CEIGFIPSPV;LAQCPPELFDVILDENQL;SSEHRHRESRHR 3 6.1 1.0033 -0.87678 0 0 0 0 9.61187 0 0 0 0 0 0 0 8.07719 0 0 A0A8C0N2Z8 A0A8C0N2Z8_CANLF Transmembrane 131 like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FGRLKKSK;LRRRFLTTT;LVLNFSATALRNSVVKYFVVKNP;MGGSLPAAQGEAE;QQAQYILMEFMKTRQ;SHNICNPTNMNNLPQY;SKETKHILKIL;SLPAGPAGVEE;SWEESFWRLTVFFVSLSL;TSTLKACL 10 7.3 0.9925 -0.55226 10.7717 0 6.35488 0 0 0 12.0003 0 10.1994 8.38664 0 0 11.959 10.6543 8.91028 A0A8C0N311 A0A8C0N311_CANLF Nuclear receptor coactivator 7 NCOA7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979] nucleus [GO:0005634] nuclear receptor coactivator activity [GO:0030374] EDDDEVALPILQ;FSPNFKVFKWSGENSY;IVQDLEVRDQRTEF;VGGVMIVTPNNIMFDP;VPRERVDH 5 6.9 0.9922 -0.18515 0 0 0 0 9.09276 0 0 0 0 0 0 0 0 0 0 A0A8C0N314 A0A8C0N314_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] membrane [GO:0016020]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] EAPCGGGC;LICFLPPPPFFLL;QESAPSSLRAAARTAGPGGTRSSW;SETVLSPTELQNLD 4 9.8 1.0031 -1.5555 9.93242 0 0 0 0 0 0 0 0 0 0 0 6.4596 9.38342 0 A0A8C0N317 A0A8C0N317_CANLF Metastasis associated 1 family member 3 MTA3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] ANMYRVGDYVYF;EGESDEREQSKLEVKVWDPN;PEMLLEGESDEREQSK;SILGKRNYSHHNGLDEL;TATGNVEAKVVCFY;TPNHTSLSILGKRNYSHH 6 12.6 0.94249 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.62029 A0A8C0N319 A0A8C0N319_CANLF Autophagy-related protein 16 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045] HLTVGLCLHVCVVTSDHLL;LRVSNIRQVFRA 2 3.6 0.93907 0.10034 0 0 0 0 0 0 0 0 6.94416 0 0 0 0 7.71039 0 A0A8C0N333 A0A8C0N333_CANLF Hflx-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; metal ion binding [GO:0046872] AAWGVQVCDRFMVVL;AGEQEEEEEDPGDAEQEEE;LPDGRGRGSRY 3 8.3 0.99126 -0.18165 0 0 0 0 0 0 6.57495 10.0557 0 0 0 0 0 0 0 A0A8C0N342 A0A8C0N342_CANLF FHA domain-containing protein PPP1R8 Canis lupus familiaris (Dog) (Canis familiaris) GSRRMQNFAFSG 1 3.4 0.9487 0.05044 0 0 0 6.71328 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N348 A0A8C0N348_CANLF ATP binding cassette subfamily D member 3 ABCD3 Canis lupus familiaris (Dog) (Canis familiaris) long-chain fatty acid import into peroxisome [GO:0015910] membrane [GO:0016020]; peroxisome [GO:0005777] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; long-chain fatty acid transmembrane transporter activity [GO:0005324] LLCLLHRRRR;LSHPRHLKSTHSELLEDYYQ 2 4.7 0.99892 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 2.46093 0 A0A8C0N362 A0A8C0N362_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020] metal ion binding [GO:0046872] EARSFMTPLSL;MYKGGKPH 2 2.3 0.98994 0.016867 0 10.4043 0 0 0 0 0 0 0 0 0 2.65608 0 9.74421 0 A0A8C0N368 A0A8C0N368_CANLF Centrosome and spindle pole associated protein 1 CSPP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cytokinesis [GO:0032467] centrosome [GO:0005813]; microtubule [GO:0005874]; spindle pole [GO:0000922] DYERKKHKLKEELRQDYRRYLT;EVSEEMDERFRYESDF;QEALQQQVFIHSL;SLQSYQEALQQ 4 12.8 0.99034 -0.26197 0 0 0 0 0 0 0 0 0 0 13.0431 0 0 0 0 A0A8C0N397 A0A8C0N397_CANLF ALK and LTK ligand 2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886] cytokine activity [GO:0005125]; receptor signaling protein tyrosine kinase activator activity [GO:0030298]; receptor tyrosine kinase binding [GO:0030971] AGTGRGARGLGGEEGRG;LPPLGLPPLGPPLGLLLALLLVL;RGAGGGAG 3 11.5 0.99057 -0.21178 0 0 0 0 0 0 6.51647 0 0 0 0 0 0 0 0 A0A8C0N3A7 A0A8C0N3A7_CANLF Protein lin-54 homolog LIN54 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] AQAEQADKKGKSKA;FANGEFCNNCNCTNCYNN;HENERQKAIKACL;LGKSGSPIV;PINSKAVTGQTTQ 5 10.7 1.0031 -1.6583 0 0 0 0 0 10.3779 0 0 0 0 0 0 6.74578 6.22943 0 A0A8C0N3B1 A0A8C0N3B1_CANLF ADAM metallopeptidase domain 9 ADAM9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] GLSLGISYDDTK;GSQCDAGLCCTDCQ;NQYMCYDGGCQDTDARCE;PLESAVEYQHLLYKLRNENTEI;PVDVTIHNGRTCK;QYMCYDGGCQDTD;YMCYDGGC 7 10.3 0.97467 0.046947 0 0 0 0 0 0 0 0 0 0 0 0 0 6.62479 0 A0A8C0N3C0 A0A8C0N3C0_CANLF SH3 domain-containing protein CACNB4 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] AGVRAPLRSPQPSPADAGDSD;EDVPVPSTAISF;QDTYKPHRN 3 6.2 0.95384 0.050564 0 6.41173 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N3C3 A0A8C0N3C3_CANLF ETS domain-containing protein ETV7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] QKLLFRNRKLILILIWN 1 6.7 0.98531 0.046227 0 0 0 0 0 3.61695 0 0 0 0 0 0 0 0 0 A0A8C0N3D8 A0A8C0N3D8_CANLF START domain-containing protein LOC119873296 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525] RDYVYIQQ;VYWQVKYPFPMYNRDYVYIQQRRD;YKVYGVLDNCLPDVL 3 19.3 0.10092 0.8562 12.2652 12.1659 10.0072 10.8225 10.8779 0 13.0866 12.644 0 12.0652 0 12.1069 8.06393 7.63503 7.83251 A0A8C0N3E3 A0A8C0N3E3_CANLF PAP-associated domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA 3'-end processing [GO:0031123] nucleolus [GO:0005730]; TRAMP complex [GO:0031499] mRNA binding [GO:0003729]; poly(A) RNA polymerase activity [GO:1990817] GGGGGGGG;IDLVVFGKWERP;VGSGGVRPP 3 5.8 1.0016 -0.75377 0 0 0 0 0 8.46091 0 0 0 0 0 0 0 4.79784 0 A0A8C0N3E4 A0A8C0N3E4_CANLF "Inositol 1,4,5-trisphosphate receptor" Canis lupus familiaris (Dog) (Canis familiaris) release of sequestered calcium ion into cytosol [GO:0051209] endoplasmic reticulum membrane [GO:0005789] "inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]" AHDENVLSYYRYQLKLFARMCL;DLDNPPKKFRDCLFKVCPMNRYSA;EPVLQHFVHLL;EVSPREVGHNIYI;GERKLESTERACD;LDRQYLAIDEISQQL;MEWQRKLRSMPLIYWFSRRMTLW;NEGFISQNDPFVI;SVNCNTSW;SVPEVLEGERKLESTERACDTL;VAVNMNDLGSQPREDREP;VGERVQSNEMGM;WNYLYFIV 13 7.1 1.003 -2.3674 0 8.39073 0 0 7.00225 0 7.58849 12.2516 10.609 8.44646 9.6034 8.50549 9.68417 9.41865 0 A0A8C0N3F7 A0A8C0N3F7_CANLF MYB proto-oncogene like 1 MYBL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] EHTASVKKVRKS;FTTSLLMIPL;LAVEANAVLSSL;NSEDEDDDLQYA;VPQQKGLKK 5 7.7 0.99416 -0.28575 0 0 0 0 0 0 0 0 0 9.12663 0 0 0 0 0 A0A8C0N3F8 A0A8C0N3F8_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] protein-disulfide reductase activity [GO:0015035] TFQMFKQTQKYAFQ 1 10.2 0.936 0.06094 0 0 11.1638 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N3G2 A0A8C0N3G2_CANLF Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] TVSAGALP;YLHRSQNRSEEFLVA 2 8.5 1.0039 -1.0385 0 0 8.96304 0 0 7.24146 0 0 0 0 0 8.39553 0 0 9.26945 A0A8C0N3H0 A0A8C0N3H0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;VQPLWKTVWSFLKQLKIY 4 5.4 0.99133 -0.27456 0 0 0 0 0 0 0 0 0 0 4.21451 0 14.4625 0 0 A0A8C0N3H5 A0A8C0N3H5_CANLF G8 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] EGVELKHMGQ;EWVQDVEWTQWFDYDK;GAWLRGGDVWLDSC;LRLKGKWYRAGWGY;LTKKKKKRKEDPE;VGQYPIHFH;VGYNSLGHC;VWLDSCRFADNGI 8 5.7 0.99721 -0.58805 5.32211 4.80972 12.1541 0 11.5783 7.14109 0 0 0 0 5.04155 8.10318 0 0 0 A0A8C0N3H8 A0A8C0N3H8_CANLF Forkhead box protein G1 FOXG1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] EAVQNDNHHASH 1 2.4 0.99458 -0.19094 0 0 0 0 0 0 0 0 0 10.15 0 0 0 0 0 A0A8C0N3H9 A0A8C0N3H9_CANLF N-terminal kinase-like protein (SCY1-like protein 1) SCYL1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AAGGGGGG;EESTDTAEDSSAADRWDDED;GGGGGGGG;IFPHVVHGFLDTNP 4 5.5 0.98853 -0.50646 0 0 0 0 0 0 0 0 0 0 7.68594 0 0 0 0 A0A8C0N3K5 A0A8C0N3K5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;NTHVRKCSASL;VIKTVWYWHRNRHIDQ;VWNQKRLRIARGILKKKTI 6 9.1 0.9536 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 8.45525 0 0 A0A8C0N3M2 A0A8C0N3M2_CANLF Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein TACC1 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ALADLNSVE;DSAGAGRS;GPEAKTQESQEVDEQL;GRKLGSKLPPKVQK;QRYQALKIHA;RKVGRKLGSKLPPKVQKDS;SKLRKPKPVPLRKKTI 7 8.2 0.98975 -0.26592 9.49125 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N3M4 A0A8C0N3M4_CANLF Protein kinase domain-containing protein TBK1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AATGSLPFRPFEGP;EDDEQFVSLYGT;FRRIARLFYW;LEEPSNAYGLPES 4 6 0.99884 -0.61146 0 0 0 0 0 0 10.4467 0 0 0 0 0 0 0 0 A0A8C0N3Q3 A0A8C0N3Q3_CANLF Ankyrin repeat domain 53 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cytokinesis [GO:1902412] EADFKEWLRCKQLL;FLKDAMWRRDKKD;LLLLFPLPLLPAPPPLL;LTEYQKEH;SFYPSPEA;VHPDPSPDHDFRSF 6 11.3 1.0019 -1.2104 0 2.28428 0 0 0 5.89176 9.87226 10.8111 10.0275 0 0 0 7.70037 0 0 A0A8C0N3Q7 A0A8C0N3Q7_CANLF Copine 7 CPNE7 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent phospholipid binding [GO:0005544] FSTTYEEMQ;RLGQPGVQPVSVS 2 3.8 1.0043 -1.0787 0 0 8.47707 0 0 0 7.28485 0 0 0 0 0 0 0 0 A0A8C0N3S5 A0A8C0N3S5_CANLF FAD-binding PCMH-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752]; taurine biosynthetic process [GO:0042412] cytoplasm [GO:0005737] pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782] GPAAPGTLHVEGGGR 1 8.7 0.99131 -0.14765 0 0 0 0 0 9.36354 0 0 0 0 0 0 0 0 0 A0A8C0N3T8 A0A8C0N3T8_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ELQSFLFSLFFGIYIFTIMGN 1 8.1 0.95009 0.049722 0 0 0 0 0 0 7.6642 0 0 0 0 0 0 0 0 A0A8C0N3U9 A0A8C0N3U9_CANLF Regulator of G protein signaling 11 RGS11 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] DPVGRAHFLAF;GGDIAEWLIQKYC;LDDAQLHIYMLM;VIACQERTYWLVN 4 10.5 0.98492 -0.44461 0 0 0 9.49496 7.80394 0 0 0 0 10.2052 9.53629 0 0 0 0 A0A8C0N3V1 A0A8C0N3V1_CANLF PBX homeobox 4 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GSFKKRLPFILLNG 1 10.4 0.9325 0.060769 8.15305 7.98993 0 0 0 0 8.65245 0 0 0 0 0 0 0 9.16242 A0A8C0N3W4 A0A8C0N3W4_CANLF Protein zwilch Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] RZZ complex [GO:1990423] CRDRKKKK;GVSEWPEPLE 2 2.9 0.99646 -0.57987 0 0 0 0 0 0 10.9266 11.2113 0 0 0 0 3.38764 0 0 A0A8C0N3X3 A0A8C0N3X3_CANLF UBC core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAPGGPGD;PGGPGDGP 2 1.6 1.0021 -1.3703 0 0 0 0 0 0 0 0 0 0 0 8.91313 0 0 8.28045 A0A8C0N404 A0A8C0N404_CANLF Nucleoside phosphorylase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleoside metabolic process [GO:0009116]; nucleotide catabolic process [GO:0009166] cytoplasm [GO:0005737] uridine phosphorylase activity [GO:0004850] EDVLYHLSLS;LGLDHPGA;PSAVGSQSD;TSTTAATG;VLAAMCSACG 5 8.5 1.0045 -0.80421 0 0 0 0 0 0 0 0 0 0 0 3.51778 0 0 0 A0A8C0N411 A0A8C0N411_CANLF Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1) EDC3 Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] P-body [GO:0000932] mRNA binding [GO:0003729] RPTRYRHDENILESEPIV 1 3.7 0.98386 -0.25538 0 0 0 0 0 0 0 0 0 0 0 0 8.00641 0 0 A0A8C0N422 A0A8C0N422_CANLF Epithelial membrane protein 2 EMP2 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] GGGGGGGE;GGGGGGGG;QAVQATMILSTILCCI;SIYTDRREDLHKNN 4 15.2 0.99204 -0.18477 0 7.55689 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N438 A0A8C0N438_CANLF PLAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] FSESLVTLTSSV;GNSFLLGNVLLRQIRIPSAVL;HYQNQEILG;LVCYCAFIQ;MQKVKVTVL;SVLQHLEQSHW;VLLRQIRIPSAVLLP 7 4.5 1.0018 -1.211 0 8.78885 0 0 0 0 9.70696 11.5417 0 12.0471 12.3726 12.2855 5.65208 0 0 A0A8C0N451 A0A8C0N451_CANLF Peptide-methionine (R)-S-oxide reductase (EC 1.8.4.12) Canis lupus familiaris (Dog) (Canis familiaris) protein repair [GO:0030091]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743] RKERKKKERKKRKKERRQFYCR 1 11.7 0.974 0.046699 0 0 0 0 8.52274 0 0 0 0 0 0 0 0 0 0 A0A8C0N466 A0A8C0N466_CANLF RWD domain containing 4 RWDD4 Canis lupus familiaris (Dog) (Canis familiaris) ELEALRSIYEGD;KGELPRGWNW 2 12.4 0.99033 -0.26182 0 0 10.378 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N471 A0A8C0N471_CANLF BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) ABRAXAS1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA repair [GO:0006281] nucleus [GO:0005634] APRHPAAFRDSKRP;AQTQAARE;IDIQKYIPCY;LMVEYTDVPEA;MSEQLGYKTIS;RRRDAEGPG;VLSGFVLGALAFQHLNTDS 7 15.1 1.0019 -1.4371 6.94052 0 0 9.12856 0 11.0605 0 10.056 7.88429 0 0 8.33972 0 0 0 A0A8C0N475 A0A8C0N475_CANLF KIAA0825 Canis lupus familiaris (Dog) (Canis familiaris) EDFNTLREIL;KQASNTDNNLNQGSSLIESI;LLEEIFVSLRT;VELKKASL;VIQSIEQEKPNWIE 5 5 1.0038 -1.6772 6.78411 0 11.4019 0 0 0 0 8.60014 10.9034 0 9.17453 0 0 6.23555 0 A0A8C0N478 A0A8C0N478_CANLF Fumarylacetoacetase-like C-terminal domain-containing protein KCNIP3 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ISCLIINSPP;KVVCVGMN;VGTGVWATT;VSARDWQMRRNGKQWLL 4 10.8 1.0019 -1.4157 7.31016 0 0 6.8282 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N497 A0A8C0N497_CANLF WD repeat domain 5B Canis lupus familiaris (Dog) (Canis familiaris) SASRSKQMPEKPD 1 3.9 0.93866 0.060708 0 0 0 0 0 0 0 0 0 0 0 0 0 7.1818 0 A0A8C0N4B3 A0A8C0N4B3_CANLF YqgF/RNase H-like domain-containing protein SRBD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] GQGFREAEKIKRLLLNF;IVCLEDLQV;KNYFAPLDVVYCIVSE;LSSASEEDDKE;VEMNWDIVQVLSERTNIELWVCAN 5 8.2 0.99898 -0.60915 0 0 5.03896 0 0 11.0423 0 10.4758 0 0 0 0 0 11.8294 10.7606 A0A8C0N4D3 A0A8C0N4D3_CANLF BCL6 corepressor LOC119868738 Canis lupus familiaris (Dog) (Canis familiaris) IMKMTHSELMK;NLPVKKYCMDRWPMNKPPAMDI;TIVEETPEDPLQKA;YSGRTIMKMT 4 8.8 0.86087 0.16397 0 0 0 0 0 8.16967 0 0 12.7015 0 0 0 0 0 0 A0A8C0N4E3 A0A8C0N4E3_CANLF NCK associated protein 1 like Canis lupus familiaris (Dog) (Canis familiaris) LKADTSSPEEEYKVACLLL;YYQSFVDVMEFRN 2 2.8 0.9406 0.059608 0 0 0 0 0 0 0 0 0 5.26795 0 0 0 0 0 A0A8C0N4H3 A0A8C0N4H3_CANLF Extracellular leucine rich repeat and fibronectin type III domain containing 2 ELFN2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] DLHDILDYW;KESSHHPLQRQL;LPARPASHPTPYSTD;SAAPPGALERPSFLSPP;THKIWERFRP;VDAGSVVH;VPDHPAAA 7 9.7 0.99908 -3.176 0 7.37912 10.1475 0 0 0 7.16078 0 0 0 7.67143 0 10.9484 10.7388 10.7136 A0A8C0N4H9 A0A8C0N4H9_CANLF Kinesin motor domain-containing protein KIF13A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DEDGDDMDSYQEEDLNCVR;DLSANEQLVGPHAS;ELLEFLSDGA;FEKETGPPDHDL;FWSMDESN;GDDMDSYQEE;KREKKIILKLIYLE;LMYERELEQLRQ;MPSPQAHN;SYQRDDEDGDDMDSYQEED 10 5.5 1.002 -2.6011 7.11873 0 9.06242 4.48459 0 10.5477 10.0511 0 0 8.22246 8.8049 9.70846 0 0 9.74541 A0A8C0N4I9 A0A8C0N4I9_CANLF RHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-NFAT signaling cascade [GO:0033173] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEIDMELFHQNHLI;EEQISFFAAQNSISP;EEQISFFAAQNSISPLQ;GVSEKQLTSNTVQQHPS;PSTPKRHTVLYI;VLYISPPPEDLL 6 4.5 0.98841 -0.47397 0 0 10.6994 0 0 0 7.68643 0 0 11.6347 0 5.93336 0 0 7.74497 A0A8C0N4J2 A0A8C0N4J2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGDCNTDSDGYSK;DEESLADLSSLSILRLSHNSISH;LLLLLLLL;LLLLLLLLL;SLVWVCIIYQTRKKS;VLLLLLLLL;VLLLLLLLLLR 7 5.7 0.98135 0.035491 0 0 0 0 0 4.56523 0 0 0 0 0 0 0 0 0 A0A8C0N4L3 A0A8C0N4L3_CANLF argininosuccinate synthase (EC 6.3.4.5) ASS1 Canis lupus familiaris (Dog) (Canis familiaris) arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] cytoplasm [GO:0005737] argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524] VIKAARRRRPAR 1 2.9 0.94235 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 9.13363 0 0 A0A8C0N4L9 A0A8C0N4L9_CANLF 40S ribosomal protein S15a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] VMMKHESIEMGILYL 1 25.4 0.94847 0.081735 0 0 0 0 0 0 0 0 6.5246 0 0 0 0 0 0 A0A8C0N4M3 A0A8C0N4M3_CANLF Protein TBATA Canis lupus familiaris (Dog) (Canis familiaris) AASASPDPQPARWD 1 2.9 0.99158 -0.14476 0 11.0895 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N4P4 A0A8C0N4P4_CANLF Progesterone receptor membrane component 2 PGRMC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALVALVLLGAYRLWVRWGRRGLGTG;EEPSEYTDEEDT 2 15 0.9426 0.085978 0 7.24831 0 0 4.85624 0 0 7.93658 0 0 0 8.60348 0 6.37215 0 A0A8C0N4Q3 A0A8C0N4Q3_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] EGAQNRYPWSEACLIIQH;GVTMTVCNVSL 2 6.6 0.94291 0.083804 10.0048 0 0 0 0 0 6.8031 0 0 0 0 0 0 0 0 A0A8C0N4Q9 A0A8C0N4Q9_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVGSELTRHQ;HSSALTEHQRIHTG;RIHTGEKPYKCIQCEKVF;TDEKPYKCMEC;VFHFPSLSDLES 5 13.5 1.0027 -0.79245 8.86372 0 0 0 8.5738 0 0 0 0 0 0 0 0 0 7.06609 A0A8C0N4R8 A0A8C0N4R8_CANLF Solute carrier family 30 member 4 SLC30A4 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion transmembrane transport [GO:0071577] membrane [GO:0016020] monoatomic cation transmembrane transporter activity [GO:0008324] TAIVHIQLI;VHIQLIPGSSSKW 2 3.7 0.98937 -0.51823 0 0 0 0 0 8.10538 0 0 0 0 0 0 0 10.5963 0 A0A8C0N4S3 A0A8C0N4S3_CANLF SAM pointed domain containing ETS transcription factor Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" EDPEQCPV;HYCASTSEDSWTDSEVDSSCS;IRQYYKKGII;PGGLTLEEHSLEQ;SEEQFRQRSP;TLEEHSLEQ 6 19.2 1.003 -2.1923 12.0176 0 0 0 0 8.64093 0 0 0 0 0 0 0 0 0 A0A8C0N4V3 A0A8C0N4V3_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; visual perception [GO:0007601] plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CRCSTREKLTM;GVVFPDMYPWTSA;IHTCIFSYQLQLPTLLDSSSQG;IPMMYPAS;LSDLLCGYPEG;LVLLDEPTTGMDP;PIFMVLAWIYSV;RKRQKIRFVVELVWPLS;SLYADRLVGTYSG;STFEELERLRKLVKAW;TDRTLRLT;TEPITEEMEDPEHPEGI;VNELMDMVQHHVPEAKLVECIGQ 13 8.1 0.97763 0.047789 0 0 0 0 0 0 0 8.49349 0 0 0 0 0 0 0 A0A8C0N4Y1 A0A8C0N4Y1_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] GGGGGGGG;GGGGGGPG;IVSPKQEHEDRKHDKVT;LPRDSRARF 4 9.1 0.99415 -0.28534 0 0 0 0 0 0 0 0 0 0 0 0 10.3058 0 0 A0A8C0N4Y2 A0A8C0N4Y2_CANLF F-BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] GVVALEALAP 1 2.2 0.99004 -0.26397 0 0 0 0 0 0 0 0 11.7667 0 0 0 0 0 0 A0A8C0N500 A0A8C0N500_CANLF DUF4209 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGSIKLLSPVLYLILLLIAL;RQRQTYLH;WEAALIRFRSHI 3 7.9 0.98966 -0.26571 9.07577 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N502 A0A8C0N502_CANLF Transcription elongation factor spt6 SUPT6H Canis lupus familiaris (Dog) (Canis familiaris) nucleosome organization [GO:0034728]; transcription elongation-coupled chromatin remodeling [GO:0140673] transcription elongation factor complex [GO:0008023] DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491] AEESEEEYNDEGE;DDDDEDEGEEDEGSD;DEDEGEEDEGSDSGDSEDD;EEYGKEEHEKEAIA;ELAILYMNSKKSEAEFRDYPP;ELHINDLWRVWQWDEKWTQLRIRKE;GFINDDDDEDEGEEDEGSDSGD;GVDFDYDEFEKYNEYDE;IKTKKEKPTFIP;KPRIEYVTVTPEG;LDNGVTGFIPT;LEYDESAE;MLTKETPE;RTSFDDRLE;SFKYLKNKPVKELR;TKFLSDKVVKRPE;VIAHPSFHNINFKQAEKMMETM 17 13 1.0032 -2.3735 7.48446 8.83403 9.35493 9.67117 0 0 8.45199 5.56526 8.0806 0 3.91476 9.16272 7.73254 0 0 A0A8C0N516 A0A8C0N516_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NSPQKLISCR 1 3.2 0.99035 -0.26838 0 0 9.34165 0 0 0 0 0 0 10.9444 0 0 0 0 0 A0A8C0N530 A0A8C0N530_CANLF Large ribosomal subunit protein uL4 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] VGKKGKKAVGVKKLK;VGKKGKKAVGVKKLKKPC;VGKKGKKAVGVKKLKKPCGRKKG;VGVKKLKKPCGRKK 4 6.1 0.99436 -0.12319 0 4.48465 0 0 9.78661 3.79473 0 0 0 0 0 0 4.18793 0 0 A0A8C0N531 A0A8C0N531_CANLF G protein-coupled receptor 149 GPR149 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AGGGAASRRCGQVLAVVLTVWAASL;ECKTAKDSQRDT;KDSQRDTHSIFN;RQVTWTGVKVRSTELGET;TCLMTLAA;TEAEQDCHGEKSVD 6 10.9 1.0026 -1.7855 0 0 0 0 8.41287 0 0 10.2936 0 0 0 5.0354 0 12.0222 8.97908 A0A8C0N542 A0A8C0N542_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoatomic anion transport [GO:0006820] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] HCCLYPVHSHCCRFWSWSPHCTQ;QAPVCCSARYNLAV;YIASKVGG 3 10 1.0017 -1.2628 0 0 0 0 0 0 0 0 0 9.34926 0 0 10.79 0 9.31004 A0A8C0N547 A0A8C0N547_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein tyrosine phosphatase activity [GO:0004725] DGKFGFNLKG;ISFKRKKFFI;VLIRITPDEDGK 3 3.9 1.0024 -1.1519 0 0 0 0 0 0 12.3012 12.1773 0 0 0 0 0 0 0 A0A8C0N551 A0A8C0N551_CANLF Semaphorin 3B SEMA3B Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor binding [GO:0030215] FDQLRPFPTEDVFLLSLRDRWS;LVEPGGGGAGSL;PGAEGDTHFDQLRP;RVFGVEGGSAFLECEPRSLQ;VYSMNDVRRAFLGPFAHKEGPMHQ 5 11.4 0.87264 0.13753 0 0 8.60811 0 0 0 11.4027 0 0 0 6.86827 0 9.50593 8.10962 0 A0A8C0N5B3 A0A8C0N5B3_CANLF Bublin coiled-coil protein Canis lupus familiaris (Dog) (Canis familiaris) AGAEGEDDGFGEAEYA 1 21.6 0.96227 0.049233 0 0 7.72942 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N5B9 A0A8C0N5B9_CANLF HORMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly checkpoint signaling [GO:0007094] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654] VLEKWEESGPQFV 1 12.5 0.93966 0.05983 0 0 0 0 0 0 0 0 0 0 0 0 0 5.42603 0 A0A8C0N5C1 A0A8C0N5C1_CANLF KN motif and ankyrin repeat domains 1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] AGSRRDAA;ALMCASEHGHVEIV;ESDDECDVIEFPPEEEEEE;IKKLNIPKRRKPSVPCP;LASFGGMG;SCAISVTEAMLGV;SMGSSIRHSPLSSGI;TGQQGVWTSTESLSS;VGDEPVGEFMESPQP;VGDYIAAFEAISPD;VLSGSAGFDRPSAVKT;VTKTLMETRRRLEQERVT;YEEEEMESVEQ 13 14.3 0.99218 -0.20744 0 0 0 0 0 0 0 0 0 0 0 0 8.57262 0 9.76401 A0A8C0N5F0 A0A8C0N5F0_CANLF PABIR family member 2 PABIR2 Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase inhibitor activity [GO:0004865] AESPVACSNSCSPFIL;ESLSLSDSDFEKPEKL;SSGLSSDSLAKGS 3 13.4 0.98694 -0.38254 0 0 9.63152 12.8128 10.7911 8.99042 0 0 0 0 0 0 0 0 9.07304 A0A8C0N5F9 A0A8C0N5F9_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] AASMTSRTSLA;PFFEPFRDP 2 6 1.0037 -1.1038 9.44886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N5G0 A0A8C0N5G0_CANLF Cation/H+ exchanger domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] SFQLRFAHVFWMMSDKNTFKY;TDPVTVLAIFHEL 2 7.7 0.95315 0.049851 0 0 0 0 0 0 7.97545 0 0 0 0 0 0 0 0 A0A8C0N5H7 A0A8C0N5H7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CDLTSRSQPSSV;DPSPQTQVVKS;ESKLPCVNSTGCKLGPPLQ;ETHVESRKVTMEPHL;ITGAKRHV;KGVKSELNP;KSVPLTPGPR;LQDIQSVGFE;LTSEPKHQ;PVALGSPMGMIIASQS;QDVRFSDL;QSQIVETPDLTSRP;QVENIQETMPVPPHLVQ;SAPELQLQVVNSD;SLQSSPRAQLQGV;SMVFNPDR;TEFNFGPQLQNV;TPQPYHQRTETMAL 18 6.6 0.98825 -0.2251 0 8.18031 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N5K1 A0A8C0N5K1_CANLF NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) NQO1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] HGDMNIILWPIQ;PITCTPPCRDAQGRVPPSPVPP;PVPPRRDAQGRSPPS 3 9.2 0.85351 0.15177 0 0 0 0 9.65582 8.86372 0 0 7.20535 0 0 0 0 0 9.34722 A0A8C0N5L0 A0A8C0N5L0_CANLF IQ motif containing H IQCH Canis lupus familiaris (Dog) (Canis familiaris) EAGGAAGDERTGD;IDQKSFVFPLESEGKLW;MQLGRLCDILDANV;PVEATKFSPKKRRSQG;TFARNLFIIH;YFTPIPVP 6 6.2 0.98668 -0.3209 0 0 0 9.31558 9.67301 11.5755 11.3536 12.0293 13.2554 0 11.3572 0 0 11.2513 11.6115 A0A8C0N5L3 A0A8C0N5L3_CANLF Solute carrier family 7 member 11 SLC7A11 Canis lupus familiaris (Dog) (Canis familiaris) neutral amino acid transport [GO:0015804] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] VLKKKITLVRGISIII;VVLKKKITLVRGISIIIGTI;YAGWFYLNF 3 5.8 0.99455 -0.1252 0 4.55053 0 0 0 0 0 0 0 5.25047 0 0 0 0 11.5734 A0A8C0N5N1 A0A8C0N5N1_CANLF Peptidase S1 domain-containing protein GZMB Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] LLLLERKAKLTAAVKTLPLPRG;QVRLSVCLAWLWGQGCLG;SECEFLLPKYYDSTT 3 24.2 0.99011 -0.22056 0 0 0 0 0 0 0 0 7.71678 0 0 0 8.26097 0 0 A0A8C0N5P4 A0A8C0N5P4_CANLF Glypican 4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] VGAQPYLLAVF 1 2.2 0.98226 -0.25119 0 0 0 0 0 0 0 0 0 0 0 0 0 9.20298 0 A0A8C0N5P5 A0A8C0N5P5_CANLF Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN1 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] oligosaccharyltransferase complex [GO:0008250] LVVAAFYIL;RLLLLLLL;VGYNLPSYEYLY 3 5.1 0.9922 -0.17764 0 11.9036 0 9.00904 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N5P6 A0A8C0N5P6_CANLF GLIS family zinc finger 3 GLIS3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] DAAADGAVG;TKPYACQIPGC;VGHPSPGQNVQGS;VLTNGKPRYQVTQAGGMSGP 4 5.7 1.0021 -1.3073 0 0 0 0 0 0 0 0 10.2922 0 10.813 0 0 0 0 A0A8C0N5Q8 A0A8C0N5Q8_CANLF FUN14 domain containing 1 FUNDC1 Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422] mitochondrial outer membrane [GO:0005741] TAVGGGFLLLQATEFIK 1 15.2 0.97669 0.04642 0 0 0 0 0 8.58571 0 0 0 0 0 0 0 0 0 A0A8C0N5S2 A0A8C0N5S2_CANLF CCHC-type domain-containing protein TUT4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of gene expression [GO:0010629] cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; nucleotidyltransferase activity [GO:0016779]; zinc ion binding [GO:0008270] FDKFILTSGKPPTIVCSIC;FRLEKEKQEESELRSLPP;IDSQTDGGIPSYC;ILKKSVLY;RKPPVIPV;TVGNSEPG 6 4.8 1.0033 -1.5594 0 12.5108 0 0 0 0 0 0 0 8.75642 0 0 0 0 0 A0A8C0N5T1 A0A8C0N5T1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DNNDIEVETDTH;HKNRAYTEDSLHSVWDPHPIT 2 35.5 0.98941 -0.21557 0 0 0 0 0 0 0 0 11.9742 0 0 0 9.2863 0 0 A0A8C0N5V9 A0A8C0N5V9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase makorin-1) Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AVGEYRYGENCVYLHGDSCDM 1 6 0.97402 0.047166 0 0 0 0 0 0 0 5.88037 0 0 0 0 0 0 0 A0A8C0N5X8 A0A8C0N5X8_CANLF Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase inhibitor activity [GO:0004864] SREHRAGS;TREAQERGREKPG;VGKAAGPA 3 5.7 1.0025 -1.7668 6.37705 6.79051 0 6.99254 9.65732 0 0 7.00338 0 0 8.53675 0 0 0 0 A0A8C0N5Y6 A0A8C0N5Y6_CANLF Arf-GAP domain-containing protein ARFGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] GRRGGQGLPPREA;LSFVRSVTMDKW;TCGSLSSKVAGPSL 3 6.4 0.9958 -0.11459 8.71263 0 0 0 0 0 0 0 0 12.0743 0 12.0315 0 9.14188 0 A0A8C0N615 A0A8C0N615_CANLF Origin recognition complex subunit 2 HYCC2 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] cytoplasm [GO:0005737]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; plasma membrane [GO:0005886] ARGIFRLLIKYQLD;GVVEEWLSEFKAL;GVVEEWLSEFKALPDTQI;VLNHMGTFRSVLDQLDW;YNWLWYETTTYSPY 5 7.4 0.9879 -0.48969 0 0 0 0 0 0 9.38424 11.262 0 8.55175 0 0 0 0 0 A0A8C0N670 A0A8C0N670_CANLF RNA helicase (EC 3.6.4.13) DDX25 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] ECSRQRRPAEGFQHL;EDMDEIENIEY;QKDPSSPLYS;VLDEADVMIDTQ 4 7.8 1.0031 -0.85964 0 0 0 0 0 0 0 0 9.14944 0 0 0 4.58033 0 4.49997 A0A8C0N684 A0A8C0N684_CANLF Tr-type G domain-containing protein GSPT1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] AKEKNRETWYLSWA;GGGGGGGG;GQRSGGGGGGGGGGSSSGSSS;GSSSSDSAPDCWDQADMEAPG;KNRETWYLSWALDTN;LAKTAGVKHLIV;TEKKHFTI;VPNVHAAEFVPSF 8 13.3 1.0024 -1.3599 0 10.0524 0 0 13.2537 12.5838 7.33333 0 0 0 0 0 0 0 6.40062 A0A8C0N6A6 A0A8C0N6A6_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) basal plasma membrane [GO:0009925] transmembrane transporter activity [GO:0022857] NSWMLDLFQSAVNVGFF;RLNLYLIPSI;RPKGRLCLRLLMKLKTCR 3 8.2 0.98921 -0.20324 0 0 8.23716 0 0 0 0 9.28306 0 0 0 0 0 0 0 A0A8C0N6B8 A0A8C0N6B8_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] RETHLPWGSEPWT 1 11.2 0.93995 0.059836 0 0 0 6.90533 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N6C2 A0A8C0N6C2_CANLF Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) PCMT1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; protein modification process [GO:0036211] cytosol [GO:0005829] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] ASGAVTVWEVVSLLGKLLGT;DKEKQWSRDE;QLVVGDGR 3 13.3 1.0043 -0.81853 8.98194 8.93661 0 8.37456 0 0 8.66306 0 8.83952 0 0 0 0 0 9.07205 A0A8C0N6C7 A0A8C0N6C7_CANLF Structural maintenance of chromosomes protein 1A SMC1A Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062] meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] AEEDTQFNYHRKKNIAAERKEAKQE;ESIKRLYPG;EYKINNKV;IVGGSSEYKINNKVVQLH;QEFEERMEEESQSQ;RRIDEINKELNQVMEQ;VISGGASDLKAKAR 7 11.8 1.0023 -0.72497 10.147 0 9.76255 0 7.74396 7.96982 0 10.7039 0 0 7.79604 0 9.88934 0 0 A0A8C0N6D0 A0A8C0N6D0_CANLF B box-type domain-containing protein TRIM80 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] GVALALRRRLPVLLRR;HQLLEPVWDLKSRLC 2 6.5 0.95994 0.049233 0 0 0 0 5.0754 0 0 0 0 0 0 0 0 0 0 A0A8C0N6G0 A0A8C0N6G0_CANLF Transmembrane protein 232 Canis lupus familiaris (Dog) (Canis familiaris) ACLKALMELMRDF;PVENKKSYKNIDAEMG;SITKEFIVRFNQT;YLKKKDSVKKRVLRVTVR;YYGLMYNLVKMSWELRGD 5 11.8 0.96021 0.049233 0 0 0 0 0 0 7.71555 0 0 0 0 0 0 0 0 A0A8C0N6J9 A0A8C0N6J9_CANLF Winged helix Storkhead-box1 domain-containing protein STOX2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DLAEGCSQDDQTP;EASFDYYNVSDD;GPGGGPAA;KERSRSMDNSKGPLGASSLG;PAASGAVAEGIAN;RNHCDSCHCCREDMHS;TPSQSYIDDSTL 7 10.3 0.98682 -0.41867 0 12.1238 5.79348 9.61681 0 0 0 9.1267 0 9.49687 0 10.9191 0 0 0 A0A8C0N6K0 A0A8C0N6K0_CANLF tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) TRMT61B Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] tRNA (m1A) methyltransferase complex [GO:0031515] tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107] PLETARALCG;VGAQGRVISFEIRKDH 2 5.3 0.99419 -0.56222 0 0 0 0 7.08172 0 0 0 0 9.71649 0 0 0 0 0 A0A8C0N6K5 A0A8C0N6K5_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] CKSFWKICV;RPKHVVVKFVVKFFPPDHTQLQE;VDSESDLLREQASQSRSQTND;VFQGFTKINA 4 8.4 0.97735 0.047846 0 0 8.779 0 0 8.90406 0 0 0 0 0 0 0 0 0 A0A8C0N6L0 A0A8C0N6L0_CANLF Large ribosomal subunit protein uL3 (60S ribosomal protein L3) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] DTTSKFGHGRFQ;EASLKIKAALPAVL;NASTDYDLSDKSINPLG;TLRKSLLVQTKRRALEKI;TSRWHTKKLPRK;VGTKKRVLTLRKSLLVQ 6 19.1 0.81124 0.20169 0 0 7.95099 0 5.31368 0 0 0 2.91602 0 0 0 0 8.33029 0 A0A8C0N6L2 A0A8C0N6L2_CANLF Nucleoside diphosphate kinase (EC 2.7.4.6) Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; regulation of apoptotic process [GO:0042981]; UTP biosynthetic process [GO:0006228] cytoplasm [GO:0005737] ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] AGPTPGPG;NIIHGSDSVKSA 2 6.5 1.0044 -1.0539 0 0 7.64393 0 0 0 0 0 9.33347 0 0 0 0 0 0 A0A8C0N6M0 A0A8C0N6M0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAQRRGEQGAQQP;GGRGGTAG;LVSLLKLKVLPHHDELR 3 12.2 0.98618 -0.42157 0 0 0 0 0 0 9.49039 10.6431 10.0116 0 0 0 0 0 0 A0A8C0N6N6 A0A8C0N6N6_CANLF type I protein arginine methyltransferase (EC 2.1.1.319) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein-arginine N-methyltransferase activity [GO:0016274] ATYHRAILQNH;GSGILSFFAVQ;QDFVRTAT;VIISEPMGYMLFNERMLESYLHSK;YFRQPIVD 5 13.6 1.0031 -2.109 9.76399 8.98704 0 9.8182 0 0 10.2916 0 0 0 0 0 0 0 0 A0A8C0N6P6 A0A8C0N6P6_CANLF Leucine zipper protein 4 Canis lupus familiaris (Dog) (Canis familiaris) RRDEYFQKQMQQRHDQMNKNRRM;YDRYLIMKRRDEYFQKQMQQRHDQ 2 5.4 0.9842 -0.24729 0 8.38957 0 0 0 0 0 0 0 0 0 0 0 7.3535 0 A0A8C0N6R9 A0A8C0N6R9_CANLF Uncharacterized protein C20H19orf25 Canis lupus familiaris (Dog) (Canis familiaris) AAERPAPRPPPGDP;GAGFPGNG;SSAAPAVLLARGRE;VGGCCESHCC 4 11.3 1.003 -1.9089 0 0 0 0 4.99345 0 0 8.80632 0 0 0 0 10.2912 9.66658 0 A0A8C0N6S3 A0A8C0N6S3_CANLF Ankyrin repeat and MYND domain containing 1 ANKMY1 Canis lupus familiaris (Dog) (Canis familiaris) EGEDPFYYDYKRFLLDDDLTLPP;FAKESQWDPK;GPASVYHSQRASA;GTGSWLSCSGCCGASC;LDDDLTLPPEMYIYSTDNSH;VTDVDARAADQDDV 6 8.1 0.96019 0.049233 0 0 0 0 0 5.54535 0 0 0 0 0 0 0 0 0 A0A8C0N6U9 A0A8C0N6U9_CANLF Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4) Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165] QPCCGCSS;VAAGPMPL;WSMPCSQQPCCGCS 3 10.2 1.0019 -1.3065 0 0 0 3.73574 7.27408 0 0 0 0 0 0 0 0 10.7648 0 A0A8C0N6V6 A0A8C0N6V6_CANLF HOOK N-terminal domain-containing protein CCDC88B Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent intracellular transport [GO:0030705] cytoplasm [GO:0005737] DLLPACAA;DLTLQESGPTVATQKCPEN;ELEQAALERQEF;EQAALERQEFLRE;LSEELAQARKT;QEFQHQRYQ;QRYQGLEQRLETE;QTWQGPISGEISS;VRGRELGARLEHLQSELEQAA 9 6.9 0.98449 -0.25882 0 8.66782 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N6Z9 A0A8C0N6Z9_CANLF Spen family transcriptional repressor SPEN Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] RNA binding [GO:0003723] AAGATGPP;AAKLPPPV;APRPIPSWYMKKK;DEYERRSLVHEVG;EDTEVDPPIA;EPTANQKAEVVPEV;EQQREKPQATPPESCAL;EVTLTRKEKGRQKTSRSRRKR;LVFFRQQEDQE;LVMQSEYRLHPYTV;MQSEYRLHPYTV;NDTAKSSVLDQKLQVCQTEPAKSD;PPVLVHNQLV;PYSNITVREESLKF;RNQSPQRLASQASR;SPKKDVDEYER;TDYCLLLA;VGTVNAAAGAVN;VTSVQIHGTSEERYGLV;WETYQGDYYESRYYDDPREYRDYRN;YDQDYYRDPRER 21 7.5 0.99667 -4.6852 11.1264 5.44261 9.52546 0 0 9.39322 11.778 8.70625 0 10.4592 10.9012 0 9.70917 9.83916 10.253 A0A8C0N722 A0A8C0N722_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KLKFTLEPSLGQNGFQQWYDALK;VLQELQERPSQRHQLQ 2 4.5 0.79156 0.22323 0 0 0 0 0 0 7.91217 0 0 0 0 0 0 11.2488 0 A0A8C0N737 A0A8C0N737_CANLF Nucleobindin-1 NUCB1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] calcium ion binding [GO:0005509] AALLLLPPLLLLR;AALLLLPPLLLLRAVLAVP;DEQELEALFTK;EFGDTGEGWETVEMHPAYT;FQPQLVTRRMQTLQKRRLLIS;LESLGEEQRKEAERKLEEQQRRHRE;PSSGPRAALLLLPPLLLLRAVLAVP 7 19.6 1.0019 -0.67593 8.59686 0 7.19298 0 0 0 5.52428 0 8.29719 0 0 0 4.67084 0 0 A0A8C0N742 A0A8C0N742_CANLF RNA-binding protein 48 RBM48 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] GVFDHHVQR;MEHCMHNDSLQKIQ;MHNDSLQKIQ 3 6.3 1.0027 -0.79755 0 0 0 0 0 0 12.1099 0 0 0 0 0 0 0 11.8936 A0A8C0N752 A0A8C0N752_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] actin binding [GO:0003779] AFQHAKDKRYQSSYFKYKEVYEHIK;DIVYKDDLNWLKGIGC;DNISTRKYQ;DYNSWMKGC;EASKTRYHTPL;ENLGTGIPTPVTPEIER;ENLQNYNLVTDTPL;GVVHCLDFQKMR;HDDPKIMWSLHIAKVQSDRE;IASEKEYRKDLEESI;IGSLDVEKVRKAGDA;ILHNYSYPP;ISLPYTPQVIHCRYVGDITSDIKY;IVHSKNCQTLVSDIDYRNYLHQ;KAQDVASNVNYKHTLHHYTYLPDA;KKVSQQVSKVL;KYKAEHVKQRGH;KYKDYVKKH;LVHFMQVAKMQSDR;LVHSMQVAKMQSDREYKKS;LVSDIDYKNFLHQWTCLP;MHVAKVQS;MPDTPDILLSRIN;MVLAQNNAKIMNEHLYKQAWEADK;NAYNLSDNIYKQDW;NLQNYNLV;NNALNMNKRLYTEAWDKDKTQIHIM;QSQFTTLPDPPDIEF;QVNSKQLSDLNYKA;RKVTDQISDIVY;SLMDSIPMVL;TDTPEIVLAKNNALTMSKHLY;TFSPDTPYITHSKDMGKLYSTI;TIKFTSIVDSP;TPVVSLKYTSI;TTVADRPD;TVSRLVSENKYKDYVKKHLAQG;TYKVHPDK;VEKAKKAG;VLSMNVAKMQ;VNALNLSDSHYKADWK;WHDLIAKG;WKTKFQSPVDMLS;YKKNYENTKTSYHTPRDMVSITA;YSIMLEPPDVKH 45 10.4 0.99674 -9.6065 12.3326 11.6942 9.7857 12.1848 11.839 12.6009 11.1394 11.6721 10.2206 0 10.3194 7.25927 15.0883 11.7994 4.74109 A0A8C0N764 A0A8C0N764_CANLF Receptor ligand binding region domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EFRRIIEEMDRRQEKRYLIDCE;HYHNRMIIVM 2 8.5 0.99913 -0.61146 0 8.30099 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N775 A0A8C0N775_CANLF Coiled-coil domain-containing protein 22 CCDC22 Canis lupus familiaris (Dog) (Canis familiaris) GTIMREVRDLEEQIEMEMGKKT;TELVVEAVV 2 4.3 0.98575 -0.23536 8.67387 10.224 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N782 A0A8C0N782_CANLF C2 domain-containing protein MYOF Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] CKTMKFIVWRRFKWVIIGLLILLIL;ELDLHHTI;KFIVWRRFKWVIIGLLILLILL;KWVIIGLLILLILLLF;LDPPNRPETSFL;LFDNDQVGK;PFNITPRKAKKYYLRVIIWNT;TEVGFVPTFGPCYLNL;VGEAIQFEVSIGNYGNKFDTTCKP;VIIGLLILLILLLFVAVLL;VSIGNYGNKFDTTC;WKPAEDTYTD;YDINRAVDEKGWE;YLPWAHTKPVVT 14 8.4 1.0029 -2.1129 0 8.59518 0 0 0 0 6.25161 0 0 0 9.22137 9.5716 0 6.95536 6.54038 A0A8C0N788 A0A8C0N788_CANLF Potassium channel domain-containing protein KCNK15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] AEDDRELERLARQAEPHR 1 5.5 0.97071 0.048313 10.0991 0 0 0 0 0 0 0 10.2577 0 0 0 0 0 0 A0A8C0N7D2 A0A8C0N7D2_CANLF Uteroglobin (Secretoglobin family 1A member 1) LOC100687441 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] phospholipase A2 inhibitor activity [GO:0019834] TDKIPIVQRKLIAGVLEKILVK 1 24.2 0.99212 -0.27036 0 0 0 8.68527 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N7D3 A0A8C0N7D3_CANLF "39S ribosomal protein L33, mitochondrial" SLC4A1AP Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] ADSPSPSESLASQERSDDFKKPTLP;DEAEENPIVLEFQQE;EDEDFYDSDD;FLNKTRIPPRTYR;LLHYDPIVKTKVLFVEQKKIR;MGCTWGMGEDAVEDE;NTSSQDDEMGCTWGMGED;NWEDEDFYDSDDD;TFLNKTRIPP;VEEEEEEEEEEEKEKERDERGDMET;YDLGSTHGTFLN 11 18.2 1.0024 -1.1858 6.82043 5.3444 0 8.28924 5.57507 8.35579 0 10.0653 11.6729 3.74653 0 0 3.35403 4.03007 5.24963 A0A8C0N7E2 A0A8C0N7E2_CANLF JmjC domain-containing protein TYW5 Canis lupus familiaris (Dog) (Canis familiaris) AAVAQMDF;DEKYYLRSLGEDP;FSKARRYECSL 3 10.2 1.0033 -1.5501 0 0 0 0 0 6.39096 0 12.0554 0 0 0 0 0 0 10.7252 A0A8C0N7E5 CLD4_CANLF Claudin-4 CLDN4 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; structural molecule activity [GO:0005198] GLQVMGIALAVL 1 5.7 0.95217 0.05044 0 0 0 0 0 0 0 9.29923 0 7.57433 7.972 7.24926 7.53535 0 0 A0A8C0N7E7 A0A8C0N7E7_CANLF Gamma-aminobutyric acid type A receptor subunit gamma1 GABRG1 Canis lupus familiaris (Dog) (Canis familiaris) "gamma-aminobutyric acid signaling pathway [GO:0007214]; nervous system process [GO:0050877]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; postsynapse [GO:0098794] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237] VLYTLRLTINAECY;YIIMTIFFDLSRRMGYFTIQ 2 7.7 0.87441 0.1293 9.35173 0 0 0 0 0 0 0 9.33938 0 0 0 0 0 0 A0A8C0N7F2 A0A8C0N7F2_CANLF DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; negative regulation of macromolecule biosynthetic process [GO:0010558]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA-methyltransferase activity [GO:0009008]; metal ion binding [GO:0046872] DLSNVNPARK;EVSSLLSYTQ;KVQTITTKSNSIR;MGLEYEAPKLYPA;NHVDESPVELSATRSLRRRTV;PAGGGGGSP;PYTRLAQD;SNPGDSLED;VGDKRDISRFLECNP;YHLLNYTRPKEG 10 10.2 0.99889 -2.9506 6.41843 8.8779 12.9777 4.41576 8.37777 14.9557 9.0131 0 0 10.2976 0 0 5.57359 9.95603 0 A0A8C0N7K2 A0A8C0N7K2_CANLF Olfactory receptor OR51A24 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CFHARVISFNACLAQMFFIHLFS 1 7.3 0.99309 -0.27887 0 0 0 0 0 0 0 0 10.669 0 0 0 0 0 0 A0A8C0N7M1 A0A8C0N7M1_CANLF Reverse transcriptase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] FSYWLFGP 1 1.8 1.0047 -1.1044 0 0 0 0 0 10.2161 0 0 0 0 0 0 0 0 0 A0A8C0N7N8 A0A8C0N7N8_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] catalytic step 2 spliceosome [GO:0071013] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] RPLNDVHIKDI 1 6.9 0.98088 0.035491 3.09712 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N7P3 A0A8C0N7P3_CANLF Adaptor related protein complex 5 subunit zeta 1 AP5Z1 Canis lupus familiaris (Dog) (Canis familiaris) AP-5 adaptor complex [GO:0044599] AEVSEPRYHRDTN;KLEKTCVDLL;LLSRSPMS;TDDKSELEGSTLS;VGSVSSVH;VLSATSTASHLL;VWAVGEYLSVSWDRRC 7 9.1 0.98961 -0.52622 0 0 0 0 0 0 0 0 0 0 0 13.6267 0 0 0 A0A8C0N7P6 A0A8C0N7P6_CANLF Collagen type V alpha 2 chain COL5A2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] GPDGPKGSPGPSGTPGDTGPP;GPIGARGPEGPPGKPGED;GPLGPIGPPGVRG;GSDGLPGPK;GSDGLPGPKGAQ;GVPGLKGGRGTQGPPGATGFPG;PGSAGRVGPPGPPGAPG;PLPEFTEDQ;SQIETMRS;TPGDTGPP;VGATGSKG;VGLMPGSVGPVGPRGPQGLQGQ 12 10.1 0.97447 0.046925 6.42839 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N7Q7 A0A8C0N7Q7_CANLF Family with sequence similarity 205 member A Canis lupus familiaris (Dog) (Canis familiaris) HLQQKYIQLFCGLPSLHSESL;KKPILAKLNFHLRKKILEIQ;LYTLKKPILAKLNFHLRKKIL;NVQPMVPQ;SSTALATVHAPQPTAL;WPVKPITVLT 6 6.3 1.002 -1.2145 8.65718 3.96162 9.67046 0 0 10.5783 0 0 0 0 0 0 5.91421 4.85509 3.18241 A0A8C0N7T0 A0A8C0N7T0_CANLF AT-rich interactive domain-containing protein 3 (ARID domain-containing protein) ARID3B Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677] EQPSWNLDEQLKQLY;QDPRAAPGSGLLP;SGANASSP 3 6.7 1.0031 -1.6674 0 10.1149 0 0 0 0 0 0 10.9027 0 0 0 0 0 0 A0A8C0N7W0 A0A8C0N7W0_CANLF Secreted seminal-vesicle Ly-6 protein 1-like Canis lupus familiaris (Dog) (Canis familiaris) LLLLHLLLI 1 4.8 1.0043 -0.80421 0 0 0 0 0 0 0 4.07133 0 0 0 0 0 0 0 A0A8C0N7W9 A0A8C0N7W9_CANLF Sulfotransferase (EC 2.8.2.-) SULT2B1 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] PRLDPSPSTRDAENKR;THENNISEISQK 2 8.2 0.93344 0.099673 0 0 0 0 0 0 0 0 0 0 3.25838 3.60146 0 2.81539 4.44771 A0A8C0N7X8 A0A8C0N7X8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] GVAGFRLQK 1 6.4 1.0043 -0.80421 0 11.0939 0 0 0 0 0 0 12.1404 0 0 0 0 0 0 A0A8C0N7Y5 A0A8C0N7Y5_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AEIICAIEYLHSKE;HDERFLYMLMEFVPGGELFSYLRN;IPDVIRLKQEQHVHNEKSVL;KDLIRKLLVVDRTRR;KEVSHPFLVKLFWTCHDERFLYMLM 5 15.9 0.98872 0.034182 0 0 4.77894 0 0 6.31419 0 0 0 7.13309 0 0 0 4.22612 0 A0A8C0N7Y7 A0A8C0N7Y7_CANLF LIM domain kinase 1 (EC 2.7.11.1) LIMK1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] FLGQGSGW;PDVKNSIH 2 2.7 1.003 -1.3386 0 0 0 0 0 0 0 7.43104 9.75427 0 0 0 0 0 0 A0A8C0N7Y9 A0A8C0N7Y9_CANLF SUEL-type lectin domain-containing protein EVA1C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] DEEGEEDSSD;DKAEEDSEDEEGEEDSSDSDF;MLQDFLAP;VQSAFYGQDYQ 4 8.9 1.0013 -0.74689 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9148 5.3412 A0A8C0N7Z2 A0A8C0N7Z2_CANLF Secretory phospholipase A2 receptor (180 kDa secretory phospholipase A2 receptor) (M-type receptor) Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] ELTERLGS;LEAGGACT;LVASWKYL;MVPLAVAL;PSFEFVCVWLRG;WSSTACESFL 6 3.2 0.99884 -3.1497 8.80764 0 10.7517 10.4069 10.1224 10.5215 0 11.2739 0 10.6775 10.7033 10.7334 11.0135 10.6252 10.9905 A0A8C0N824 A0A8C0N824_CANLF adenylate cyclase (EC 4.6.1.1) ADCY4 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] GVDINMRVGV;QEQEETETMENLT;TLYFREKE;TLYFREKELEK;VGVHSGSVLCGVIGLQKWQ;VIGAQKPQYDIWGNT;VLYADIVGFTRLASECSPKEL 7 8.2 1.0033 -1.5764 0 10.5511 0 0 0 9.51339 0 0 0 0 0 6.58954 0 0 0 A0A8C0N826 A0A8C0N826_CANLF Nocturnin NOCT Canis lupus familiaris (Dog) (Canis familiaris) circadian rhythm [GO:0007623] poly(A)-specific ribonuclease activity [GO:0004535] EPPYTTWKIRTSGEC;FVQCPVEALKWEERKC 2 7.8 0.93991 0.10314 0 0 0 0 0 0 7.1914 0 9.65098 0 0 0 0 0 0 A0A8C0N835 A0A8C0N835_CANLF A disintegrin and metallopeptidase domain 3-like Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] DEFKRMASQPEFE;EDITYTSN;FAAGIALY;KCRDTDKQCAELFGKFAK;LLFGFYIFLPL 5 9.4 1.0037 -1.0692 0 0 0 0 0 0 0 0 0 0 0 0 0 8.91672 0 A0A8C0N838 A0A8C0N838_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ANGEWRRD;AQPPTSHSQEEQWLEQRLER;ETDVAERR;EVPPELWPEGP;LAHVIARH 5 4.6 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 9.18621 0 0 A0A8C0N892 A0A8C0N892_CANLF ASD2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015] AEIGLGEEEVDP;HHQCFRCSACYHNPQ;NCYNCWCHH;STAPAGEEAILLPFA;TEKSSSIGSMESLE 5 5 0.99563 -0.56776 9.35432 0 0 0 5.82416 3.62947 0 0 0 0 0 0 0 0 0 A0A8C0N893 A0A8C0N893_CANLF Ribitol xylosyltransferase 1 RXYLT1 Canis lupus familiaris (Dog) (Canis familiaris) GVATYRNFPVVEAS;VLFMIYDSPWIN;VLLGNEHCNNEWINQFLKRN;WNPWEGDEKNEQQHR 4 13.8 0.99189 -0.17684 0 0 0 0 0 0 0 0 0 0 7.82311 0 9.17934 0 0 A0A8C0N8B0 A0A8C0N8B0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LLCLFRPLHVPLS;VPGACGGG;VVQVFIAAP 3 7.9 1.0018 -1.2846 2.04023 13.577 0 0 0 9.70941 0 0 4.98263 0 0 0 13.9333 0 0 A0A8C0N8B2 A0A8C0N8B2_CANLF Vezatin VEZT Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] adherens junction [GO:0005912]; nucleus [GO:0005634]; plasma membrane [GO:0005886] myosin binding [GO:0017022] DIDMDSDFRKDDFYYLSQEDR;LVSAACPF;MILFIFLIIRALRL 3 6.1 1.0018 -0.99599 8.6886 0 3.00014 0 0 5.94558 0 0 0 0 2.87238 0 0 0 8.76792 A0A8C0N8B6 A0A8C0N8B6_CANLF L-Fucosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107] DWMEEEYRHIPGEYV;RNQAAQSTLAQEAKD 2 7.2 0.9515 0.053887 0 0 0 0 0 0 0 0 8.9194 0 0 0 0 0 0 A0A8C0N8D2 A0A8C0N8D2_CANLF BZIP domain-containing protein MAFF Canis lupus familiaris (Dog) (Canis familiaris) regulation of epidermal cell differentiation [GO:0045604] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EELQKQKSE;KSAPGPGSGPAPAPAPGP;MRLELDALRGKCEALQGFA;RRTLKNRGYAAS 4 35.2 0.98756 -0.37351 0 0 0 8.82212 0 0 0 10.0456 9.81591 0 0 0 0 7.774 0 A0A8C0N8F7 A0A8C0N8F7_CANLF PAS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" EPCNTLNQASLQ;EQSSLDQRQRQHQHQHQHQRYYRT;SFPTYLPLEDRFYM;TLQVHLQGQANVAMPLYEEPM 4 9.8 0.99689 -0.094107 0 0 0 0 0 0 0 0 9.52534 5.32276 0 0 0 10.6691 0 A0A8C0N8H5 A0A8C0N8H5_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP14 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] DVCVVELQPGHAE;IEKIERIQNP;VNSTSKTFNLKAGV 3 2.2 0.98782 -0.48003 0 0 0 8.63739 0 0 5.41988 0 0 6.71768 9.91374 0 0 0 0 A0A8C0N8K3 A0A8C0N8K3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AASFGPGP;AGRCARSCCCCCCC;AGRCARSCCCCCCCC;AGRCARSCCCCCCCCCC;AGRCARSCCCCCCCCCCC;AGRCARSCCCCCCCCCCCCR;ARSCCCCCCCCCCCCRR;CARSCCCCCCCCCCC;CARSCCCCCCCCCCCCR;CCCCCCCCCC;CCCCCCCCCCCC;CCCCCCCCCCCCR;CCCCCCCCCCCR;CCCCCCCCCCCRR;CCCCCCCCCCCRRL;CCCCCCCCCCR;CCCCCCCCCCRR;CCCCCCCCCR;CKPSAGRCARSCCCCCCCCCC;CQECKPSAGRCARSCCCCCCCC;ECKPSAGRCARSCCCCCCCCC;ECKPSAGRCARSCCCCCCCCCCC;ECKPSAGRCARSCCCCCCCCCCCC;GRCARSCCCCCCCC;GRCARSCCCCCCCCC;GRCARSCCCCCCCCCCCCR;LALPLPLPLPL;PGVSEAASFGPG;PSAGRCARSCCCCCC;QECKPSAGRCARSCCCCCCC;RCARSCCCCCCCC;RCARSCCCCCCCCCC;RCARSCCCCCCCCCCC;RCARSCCCCCCCCCCCC;RCARSCCCCCCCCCCCCR;RSCCCCCCC;RSCCCCCCCC;RSCCCCCCCCC;RSCCCCCCCCCCC;RSCCCCCCCCCCCCR;RSCCCCCCCCCCCCRR;RSCCCCCCCCCCCCRRL;RSCCCCCCCCCCCCRRLLPS;SAGRCARSCCCCCCCC;SAGRCARSCCCCCCCCCCC;SAGRCARSCCCCCCCCCCCC;SAGRCARSCCCCCCCCCCCCR;SCCCCCCCCCCC;SCCCCCCCCCCCC;SCCCCCCCCCCCCR;SCCCCCCCCCCCCRRL;SCCCCCCCCCCCCRRLL;SCCCCCCCCCCCCRRLLPS 53 11.2 0.99709 -4.0063 7.49514 10.8297 10.6982 6.51602 9.70235 7.99548 10.6696 9.38795 10.0225 4.89802 11.0635 9.74942 9.91536 11.2667 10.9914 A0A8C0N8K4 A0A8C0N8K4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] VHWTFQILVMLEMTLQQGDIYTCQ 1 10.6 0.97433 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 9.27533 0 0 A0A8C0N8L6 A0A8C0N8L6_CANLF Glycine cleavage system P protein (EC 1.4.4.2) Canis lupus familiaris (Dog) (Canis familiaris) glycine catabolic process [GO:0006546] mitochondrion [GO:0005739] glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829] EDKAELDRFCDA;GLKQATEIAIL;GVFEENIGDVC;IRLKRPLK;KATSNICTAQ;LAPSHRPAAGQRL;PEEGGGGAGAHPAPAP;PLDQAQGYQQLF 8 7.8 0.9964 -0.58469 0 9.13935 7.16128 7.77841 0 15.4338 0 0 0 3.51311 9.00893 9.47306 4.57797 0 0 A0A8C0N8P4 A0A8C0N8P4_CANLF Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (Skin fibroblast elastase) MME Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] NGINTLGENIADNGGIGQAY;TYGTSWTAE 2 4.2 0.95205 0.049875 0 0 0 0 0 0 0 0 0 0 0 6.52849 0 0 0 A0A8C0N8Q0 A0A8C0N8Q0_CANLF DH domain-containing protein ARHGEF10 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AGPGGQGE;DVENGEEG 2 3.9 0.98979 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 8.68046 0 A0A8C0N8T2 A0A8C0N8T2_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) ANKIB1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CANCKSPIQ;HDFCRGCWESECLGEAHEP;HVLLKTRRI;LEMVTEDLAQ;LLCMGPQIMISEGALHP;PCGHDFCRGCWESECLGEAHEPCDC 6 7.1 1.0039 -0.824 0 11.6359 0 5.59625 0 0 3.35007 10.3406 0 5.60937 0 0 0 0 0 A0A8C0N8T9 A0A8C0N8T9_CANLF "Pleckstrin homology, MyTH4 and FERM domain containing H2" PLEKHH2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] AEKMQQLERQVIDAERQAE;DEDYEASG;ETDREKLLLMYQ;ILEYNSMRLIVSYVYKSLMTFGGHQ;QEMEIPEKSGENQIQ;SDWSSDEEDESKGR;SYDSLESPCSDDQ;VAAGSNNV 8 8 1.0021 -1.363 0 0 0 7.57403 0 8.60696 0 5.16104 10.0163 7.90995 0 0 0 0 6.08782 A0A8C0N8U8 A0A8C0N8U8_CANLF Netrin receptor UNC5 UNC5B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] DPTQDTNFLLTID;DSFPSAPA;LDEETLNTPCYC;LLGVVPPG;PSVPPDLTASAGIYR;TTQLGPYAF;VEWLKNEDIIDPT;VLPGVQLPTPPPSLQP;WIFQLKTQAHQGHWE 9 9.7 0.99913 -3.0635 14.0487 8.01653 13.7272 0 12.7278 0 0 10.0508 0 0 9.72065 0 8.50092 0 9.44016 A0A8C0N8W6 A0A8C0N8W6_CANLF RING-type domain-containing protein RNF150 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVEDIVAIMIPE;PGPGAGAG;PTPQDGEVVFTANG;QDGEVVFTANGP 4 7.9 0.99389 -0.16314 9.08036 0 0 0 0 0 0 0 0 0 0 0 0 8.48945 0 A0A8C0N8W8 A0A8C0N8W8_CANLF dynamin GTPase (EC 3.6.5.5) DNM1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; endocytosis [GO:0006897]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AGLGGAGTS;IVTTHIREREGRTKE;KFFLSHPSYRHLAD;LRMGRSYSS 4 5 1.0013 -0.92555 0 0 0 0 0 9.87464 11.9694 0 0 0 0 0 8.8636 0 0 A0A8C0N8Z4 A0A8C0N8Z4_CANLF Uncharacterized protein RXYLT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGACAGP;GGGAWAGP;IFKKKKKRKKSERKKKAC;KIFKKKKKRKKSERKKKAC;KIFKKKKKRKKSERKKKACRGRE;WNPWEGDEKNEQQHR 6 22.6 1.0026 -1.482 0 6.24838 9.52203 0 0 7.74719 0 0 0 10.7814 13.6215 10.803 10.2079 0 0 A0A8C0N8Z5 A0A8C0N8Z5_CANLF Peroxisomal ATPase PEX1 (Peroxin-1) PEX1 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome organization [GO:0007031]; protein transport [GO:0015031] peroxisome [GO:0005777] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509] GGKGSGKS;HIFQCVQHIQPPNQEQRCEILH;KLIKLLSPKQQ;LVDITLKKMDY;PEKEKSMP;QCVQHIQPPNQEQ;SPEKEKSMP;VLLDPMVKEENSEEI;VLRTASQEGYQ;VTYGKLIKLLSPK 10 6.4 1.0027 -1.1917 11.6366 0 10.257 8.84906 9.63058 0 10.2651 9.95338 11.1991 0 9.62238 0 0 0 10.2876 A0A8C0N8Z8 A0A8C0N8Z8_CANLF tRNA aspartic acid methyltransferase 1 TRDMT1 Canis lupus familiaris (Dog) (Canis familiaris) NEVYKYNFPHT 1 4.3 0.98151 0.035491 0 0 0 6.31495 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N917 A0A8C0N917_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] plasma membrane [GO:0005886]; receptor complex [GO:0043235] protein tyrosine phosphatase activity [GO:0004725] DDGSGSVLRIQPLRTPRDEAIYECV;DINIPLLPL;RTMQSIPSGPPRKV;SLPETFGDFWRMIWEQRSATVVMM;STATSITLT 5 4.5 0.93731 0.060951 0 0 0 0 0 0 0 0 0 10.5098 0 0 0 0 0 A0A8C0N922 A0A8C0N922_CANLF Lymphocyte transmembrane adapter 1 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; regulation of lymphocyte activation [GO:0051249] membrane [GO:0016020] VGIYDNATGLQMCGD 1 3.8 0.98812 -0.22519 0 0 0 0 0 0 0 0 0 0 14.3207 0 0 0 0 A0A8C0N934 A0A8C0N934_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] FLEDVTKLYH;GGRDRGTQAHLQTEV;HLQTEVPQEGQN 3 7.8 0.99414 -0.28473 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3698 0 A0A8C0N938 A0A8C0N938_CANLF Contactin 6 CNTN6 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] AKLQFAYLSYAWTFNDN;KLTNSKLCLNWEHVKTMENESEVL;LSPFEVKVGVYN;TDIDFIMSY;VGESIVLPCQVSHDPSIE;VPDISWRRLDGN 6 9.2 1.0014 -0.70235 0 0 0 0 0 0 0 12.0632 0 0 10.4566 0 13.6487 10.9537 0 A0A8C0N946 A0A8C0N946_CANLF Vascular endothelial growth factor B VEGFB Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] membrane [GO:0016020] growth factor activity [GO:0008083]; heparin binding [GO:0008201] GGCCPDDG 1 4.3 1.0039 -1.1044 0 4.85748 0 5.86666 0 3.70465 7.22988 0 0 6.24916 6.42873 6.71932 0 0 0 A0A8C0N979 A0A8C0N979_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] extracellular region [GO:0005576] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] EPAITWNKDGVQ;GGGGGGGG;HLVLSSGT;LSVDRRHLVL;MCFHQKYRTHDGTCN;TEHEARAIRDLASH 6 4.5 1.0031 -1.7187 0 0 8.58195 9.73135 0 0 9.68603 0 7.87387 11.4833 0 0 0 0 10.6781 A0A8C0N984 A0A8C0N984_CANLF NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) DUOX1 Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; peroxidase activity [GO:0004601] ARAALGLPPIT;GVTIGTLCCFPL;IGTLCCFPLV;KDGNGYLSFREFL;QEALTCELSRAEFAESLGL;SEKLVGGMEALEWQG;VLHSAGHVVNVY;VLVAVTNMNPSTL 8 6.3 0.98804 -0.47695 0 0 12.0977 0 11.9115 0 0 0 10.2873 0 0 0 6.92695 7.46883 11.9583 A0A8C0N991 A0A8C0N991_CANLF P/Homo B domain-containing protein PCSK7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ASCINLSEVFWR;GNGGQHNDNCNYDGY;LVGSFTIFWTVYYMLEIYLSQ;MLAVTFSGGD;VLVGSFTIFWTVYYMLEI;VQPTALMPKGRQ 6 7.5 0.9973 -0.1102 0 0 5.99315 0 7.69599 0 9.88133 0 13.5778 0 0 0 0 0 9.8161 A0A8C0N9B6 A0A8C0N9B6_CANLF Transcription factor E2-alpha (Transcription factor 3) TCF3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] ERMGYQLHGAEVNG;EVLSLEEKDLRDRE;QMVLSAAHPGLSEAH;SWGAGDQNSSSFDPSRTYGDGTHFS;VGSGSSGG 5 11.6 0.98185 -0.24903 0 0 0 0 0 11.1906 0 0 0 0 0 0 0 0 0 A0A8C0N9D2 A0A8C0N9D2_CANLF vesicle-fusing ATPase (EC 3.6.4.6) VPS4A Canis lupus familiaris (Dog) (Canis familiaris) endosomal transport [GO:0016197]; vacuole organization [GO:0007033] late endosome membrane [GO:0031902] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AKESIRAKCMQYLD;EPLPGQGRYTLSNSPFA;ESKGSDSDSEGDNPEK 3 10.1 0.9947 -0.15453 0 0 0 8.06345 9.29864 0 0 0 0 0 0 4.25754 9.07786 0 8.535 A0A8C0N9D5 A0A8C0N9D5_CANLF AAA+ ATPase domain-containing protein VPS4B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AASDLRHGIHLGQ;RLDFAAVGFL 2 4.9 0.98768 -0.48293 0 0 0 0 0 0 0 0 11.16 0 0 0 0 0 0 A0A8C0N9E5 A0A8C0N9E5_CANLF Protein inhibitor of activated STAT 3 RNF115 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of macromolecule metabolic process [GO:0060255] nucleus [GO:0005634] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GFFVFCFV;PGPPPVGS;TIVVNWSSEFGRNYSL 3 4.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 10.8843 0 0 0 0 0 A0A8C0N9E6 A0A8C0N9E6_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] YHWFTRMFAFFR 1 3.3 0.94134 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 11.6838 0 0 A0A8C0N9F9 A0A8C0N9F9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AHHVHDVHGVPLLHLAL;EAGVAARVALGHSQV;EVHGGGGQ;GGQGGAAH;QIDDHGAQRGV;RPERWGREQPHRRGE;VPVRLQVSYL 7 9 1.0042 -2.0211 0 0 9.32807 7.52724 9.38632 9.1682 2.91374 0 0 8.85807 9.37591 0 12.8916 0 0 A0A8C0N9G5 A0A8C0N9G5_CANLF Ubiquilin 2 UBQLN2 Canis lupus familiaris (Dog) (Canis familiaris) APAEPKIIKVT;GVGVLGTAIGPVGPVTPIGPIGP;LSQNPDLA;QLPAFLQQM 4 8.2 1.002 -1.2831 7.27025 0 8.90177 0 0 0 0 7.27015 6.93038 0 2.09919 0 0 0 0 A0A8C0N9I2 A0A8C0N9I2_CANLF Adenosine deaminase (EC 3.5.4.4) Canis lupus familiaris (Dog) (Canis familiaris) purine ribonucleoside monophosphate biosynthetic process [GO:0009168] anchoring junction [GO:0070161]; cytoplasmic vesicle lumen [GO:0060205]; plasma membrane [GO:0005886] adenosine deaminase activity [GO:0004000] DFYVSRSNPVAEGRAAHSRPLPGP;LPKAHVPGPGLSF;SLGVPLSGDFYV 3 11.9 0.85037 0.1513 0 0 0 0 0 0 0 0 6.96601 0 0 10.0639 10.1165 0 0 A0A8C0N9K3 A0A8C0N9K3_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] RSRVEEQER 1 1.3 1.0043 -0.80421 0 0 0 0 0 0 0 0 7.57645 0 0 0 0 0 0 A0A8C0N9K6 A0A8C0N9K6_CANLF Phosphoglucomutase 5 PGM5 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614] KKHLVQIKKFLVRAKLV;LVQIKKFLVRAKLVQFLRALTL;PAPDVVSDKIYQ;VAKSMKVPVYET;VEEIVRDHWAK;VQIKKFLVRAKLVQFLRAL;YEGLEPKTTYYIMRDLEALVTDKS;YETPAGWRF 8 14.7 0.99832 -0.60368 0 5.09305 0 8.79876 0 8.0608 0 0 0 5.78788 0 9.85745 13.2124 8.8182 10.9165 A0A8C0N9M2 A0A8C0N9M2_CANLF MBD domain-containing protein BAZ2B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DEEEDEEDDEDDESDDSQ;DQSIEESEDDD;EDDEEEDEEDDEDDES;EDDEEEDEEDDEDDESDDS;EDDEEEDEEDDEDDESDDSQSGTS;EDDEEEDEEDDEDDESDDSQSGTSK;EDSNEDEEEDDEEEDEEDDE;EEDDEDDESDDSQS;EEDDEEEDEEDDEDDESDDSQ;EEDEEDDEDDESDDSQ;EEDEEEEDQSIEESEDDDS;EESEDDDSDS;ESEDDDSDSESEA;GLHSASSGHSEFGGLGTLGTPTA;NEDEEEDDEEEDEEDDE;SEDSNEDEEEDDEEEDEEDDEDDES 16 10.6 0.94545 0.07684 0 6.69988 7.10706 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0N9R0 A0A8C0N9R0_CANLF RecQ mediated genome instability 2 Canis lupus familiaris (Dog) (Canis familiaris) GKYVMVMGVVQ 1 7.4 0.99796 -0.10439 0 0 0 0 0 0 0 0 10.9441 0 0 0 10.4552 0 0 A0A8C0N9R3 A0A8C0N9R3_CANLF Motile sperm domain containing 2 MOSPD2 Canis lupus familiaris (Dog) (Canis familiaris) EASSKEDIESDGKETLETVSNEEQT 1 5.2 0.99116 -0.29677 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0668 0 A0A8C0N9U2 A0A8C0N9U2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] LFEKIERHGVLPNLF;MNEKGEITTNT 2 2.8 0.9537 0.053874 0 0 0 0 0 0 4.70476 0 0 0 0 0 0 0 0 A0A8C0N9V1 A0A8C0N9V1_CANLF "Myotubularin (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)" Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] filopodium [GO:0030175]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; sarcomere [GO:0030017] phosphoprotein phosphatase activity [GO:0004721] FPAAPRGK;HNIHVMRESL;SKLTIYDARPNVN;TSALTFSI;VEQRYVEL 5 6.5 1.0031 -2.3659 0 0 0 0 0 6.01123 0 0 0 0 0 0 0 7.98048 10.5488 A0A8C0N9W2 A0A8C0N9W2_CANLF Transmembrane protein 245 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGFYGLYTWLTHTIF;ALGAQRGTTTSTMPRA;DISGGGHPYLT;ERQEALAPWPVVGLGKF;GEQALRRRRLLLLLGAGGPL;GGGGGGGE;GGGGGGGG;IIFLLVIGTLLLALLLT;LGEQALRRRRLLLLL;PGGGGGGG;VPIAVWILKKLV;WFVKNVTHS 12 13.7 1.0007 -0.92682 0 0 0 9.20562 0 7.90533 0 0 0 3.79265 0 4.59359 11.332 0 7.79546 A0A8C0N9X0 A0A8C0N9X0_CANLF Adaptor related protein complex 5 subunit zeta 1 AP5Z1 Canis lupus familiaris (Dog) (Canis familiaris) AP-5 adaptor complex [GO:0044599] GVLGGRIPPPLPLPLLLPLLLL;GVLGGRIPPPLPLPLLLPLLLLS;KLEKTCVDLL;LLLPLLLLSLLPFSLPI;TDDKSELEGSTLS;VGSVSSVH;VLSATSTASHLL;VWAVGEYLSVSWDRRC 8 11.5 0.98849 -0.47397 0 9.99053 0 0 6.06525 9.60565 3.36583 4.4274 12.1938 9.85119 10.6143 9.93091 0 0 9.89301 A0A8C0N9Z4 A0A8C0N9Z4_CANLF Myomesin 2 Canis lupus familiaris (Dog) (Canis familiaris) AGISRPSRVSEAVAALDPVDLR;GSNAWEPCNHKPIGY;RVLSANKHGLS;TAASHGALTSAC 4 8.2 0.95041 0.05044 0 0 7.45055 0 0 0 0 0 0 0 7.2364 7.38741 0 0 0 A0A8C0N9Z9 A0A8C0N9Z9_CANLF Testis expressed 9 TEX9 Canis lupus familiaris (Dog) (Canis familiaris) AEKYKLELSKSR;CLKCVRHEHHYK 2 6.5 0.95073 0.05044 0 0 0 0 0 0 10.9363 0 0 0 0 0 0 0 0 A0A8C0NA15 A0A8C0NA15_CANLF BAT2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EGGGRNIISATSLSASPTELG;EVLTKKQRRL;GGGGSGIQ;GVSMPPMPVASVAPSASLPGNH;IENCGSSPGEENEVGPMAGEGFIEV;KPPYSAFPGMQPLE;KQNNLCLE;PLEMVKPQ;PNPQVDGSLPGAAVGE;PPTRPPVDF;RSGPIKKP;SAEGFKSSQGDSGVDLSAESRE;SVPSPQTYRP;VVPPVNGV 14 8.4 0.99668 -5.2419 9.80114 5.52114 0 6.94263 0 10.0451 6.21905 9.48684 12.8473 0 2.88211 9.08905 6.34892 0 0 A0A8C0NA17 A0A8C0NA17_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 14 ADAMTS14 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AYKYIIHEDLLPL;GVCGGDNS;RQPLRRECVYT;VLDRYCSI;VQRHLCDHRRRP;YIHQNAKHSWIPYEPEDDA;YRQSLSLIERGNPSRSLEQVCRWAH 7 7.8 0.99137 -0.29762 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5704 A0A8C0NA26 A0A8C0NA26_CANLF Prostate and testis expressed 2 Canis lupus familiaris (Dog) (Canis familiaris) ILTLVFMKEEEI;RLLQLLLLGILTLV;VLRLLQLLLLGI;VLRLLQLLLLGILT 4 19.2 0.9852 -0.44021 0 0 0 0 4.70327 0 15.4185 0 0 0 0 0 0 0 0 A0A8C0NA36 A0A8C0NA36_CANLF 40S ribosomal protein S24 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] FFFIDVLHPGKATVPKTE 1 14.2 0.97312 0.048313 0 0 0 0 11.75 0 0 0 0 0 0 0 0 0 0 A0A8C0NA42 A0A8C0NA42_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FLDEPYEAI;IVYSRSMQYTEFTRHPLE;SSTIMRERK;VIDERTGDIYAIQKLDR 4 7.2 0.9876 -0.33931 9.96515 0 0 9.23125 0 0 9.40018 0 0 0 0 0 0 9.17936 0 A0A8C0NA65 A0A8C0NA65_CANLF RIC3 acetylcholine receptor chaperone RIC3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] AMEKLINRVGPNGERAQTVTSDQE;ETCSCCSHE;GEGGAGCG;TVTSDQEKRLLHQLR 4 9.1 1.0018 -1.8134 0 0 0 0 0 4.55533 0 8.0936 0 0 0 0 0 0 7.36632 A0A8C0NA76 A0A8C0NA76_CANLF Calpastatin (Calpain inhibitor) Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type endopeptidase inhibitor activity [GO:0004869] KKSQSTKPSVV;KPKSDMDAALDDLVDTL;KPLLPKVPKE;LEGMVPDD;SVLAHNQCRPSPTPN 5 7.4 1.0034 -1.5802 0 6.3439 4.60532 0 0 0 0 2.85886 5.14262 0 9.35335 0 0 0 0 A0A8C0NA77 A0A8C0NA77_CANLF ABC transporter domain-containing protein ABCA14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CRMEMKQYGVQW;GVGYHIII;ILWFLLQKRK;LYKEFTTE;RHDSLPLKVRKFYLKLYMLALQS;VLKCEYSTSAI;WDNILSPVNPHDS;YSISQITLEEVF 8 6.6 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 9.63599 0 0 A0A8C0NA83 A0A8C0NA83_CANLF Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) ELOVL2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] fatty acid elongase activity [GO:0009922] LDTIFFVLRK;VLWWYYFSKSIEFL;VLWWYYFSKSIEFLD 3 7.9 0.99488 -0.15645 0 0 0 9.29735 0 8.82963 0 0 0 0 0 0 0 0 0 A0A8C0NA92 A0A8C0NA92_CANLF Transmembrane protein 82 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASIHTLLDLCQIQ;EQRQQPGLQ;GACGVSVL;RQPQSQPSARAQPR;VGDLAAVALIN 5 16.4 1.0027 -0.71994 10.9049 0 0 0 0 12.5343 0 0 0 9.91232 0 0 0 11.353 6.70058 A0A8C0NAB4 A0A8C0NAB4_CANLF Fork-head domain-containing protein FOXN1 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel morphogenesis [GO:0048514]; hair follicle development [GO:0001942]; keratinocyte differentiation [GO:0030216]; lymphoid lineage cell migration into thymus [GO:0097535]; nail development [GO:0035878]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of hair follicle development [GO:0051798]; regulation of positive thymic T cell selection [GO:1902232]; T cell homeostasis [GO:0043029]; T cell lineage commitment [GO:0002360]; thymus epithelium morphogenesis [GO:0097536] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific DNA binding [GO:0043565]" CPSQPPFHQYSPGG;PGPGPFRLSPSDKYPSFGFEEGP 2 5.8 0.99068 -0.21104 0 9.94033 0 0 0 0 0 0 0 0 0 0 0 11.755 0 A0A8C0NAC1 A0A8C0NAC1_CANLF WD repeat-containing protein on Y chromosome EFCAB8 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CLDESERCLL;ESALSTSPYLQ;LEISGIVHM;LQRITQMSPWAGEHY;NQIHQPYNQQMWVT;SKVTWEEQL;TVASCSAI;VLSTNVQYGWMKHQ 8 7.2 0.98781 -0.48789 9.65775 0 0 0 0 8.20158 11.9848 0 9.0365 0 0 9.63338 10.1148 11.4806 0 A0A8C0NAD5 A0A8C0NAD5_CANLF AMP deaminase (EC 3.5.4.6) Canis lupus familiaris (Dog) (Canis familiaris) AMP metabolic process [GO:0046033]; IMP salvage [GO:0032264] cytosol [GO:0005829] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] EEYSIATQVWKLSSCDMCE;IFLPLFEATVHPA;WTQPRVWCGRS 3 5.6 0.86395 0.14467 0 0 0 8.93006 0 0 0 0 9.92119 0 0 0 0 0 7.40965 A0A8C0NAE3 A0A8C0NAE3_CANLF Phosphodiesterase (EC 3.1.4.-) PDE1B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DETRQILDTEDE;FRSTWTKYIQ;VAHLEGGG;VEVGDPNPDVVRFRSTWTKYIQEN;VGPTYSTV;VLNCLKNLDRWCFDV 6 9.8 1.0017 -0.69298 0 6.0741 7.99684 9.6606 0 0 0 0 0 0 0 9.52845 0 0 0 A0A8C0NAF1 A0A8C0NAF1_CANLF L-lactate dehydrogenase A chain Canis lupus familiaris (Dog) (Canis familiaris) lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] GAVGMACA;LPERKVLIVKGHKKK 2 18.4 0.95618 0.053874 0 0 0 0 0 0 0 0 0 0 4.30801 0 0 0 0 A0A8C0NAF5 A0A8C0NAF5_CANLF Arrestin domain-containing protein 3 Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769]; lysosome [GO:0005764]; plasma membrane [GO:0005886] VKAELHRPWLLPVKL 1 4.3 0.95175 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.63503 A0A8C0NAG1 A0A8C0NAG1_CANLF ELAV-like protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730] NKNVALLSQLYHSP;NLGQDADEGILWQMFG;QTGTSANEKR 3 8.8 0.9857 -0.44911 0 0 0 0 0 9.6444 0 0 0 6.90316 0 0 7.29057 0 0 A0A8C0NAG6 A0A8C0NAG6_CANLF Activity regulated cytoskeleton associated protein Canis lupus familiaris (Dog) (Canis familiaris) modulation of chemical synaptic transmission [GO:0050804] mRNA binding [GO:0003729] EFLSHLEEYLRQVGGSE;ELTPDTWACLHSPG;FKKEFLQYSEGTLSRE;GVEAPPPP;LLLLLLPL;LLLLLPLL;LPLLLPPLLLLLLPLLL;PLPLLLPPLLLLLLPLLLP;PLPLLLPPLLLLLLPLLLPS;PPLLLLLL;RQRWAGARGHTWEL;VGNEPARHTVSVGVGG 12 11.9 1.0021 -0.9052 0 10.2238 0 0 6.37288 7.15664 0 10.2123 0 10.6535 0 0 9.87778 0 0 A0A8C0NAH1 A0A8C0NAH1_CANLF REST corepressor 3 RCOR3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] EVLQEWEAEQGTQA;LPSPRRRH;NDSDYDPKKEAKKEGNTEQPVQ;PAGGGGGA;SASNVPSGKSTDEEEE;TQASNGDA;VNSALKQKMEGGIEEF;WTTEEQLLAVQGV;YHSIPDAKLDEYI;YRRRFNLE 10 21.5 0.99923 -3.1252 0 10.5574 14.7309 0 0 0 6.41757 11.8209 9.99591 0 7.35808 7.88582 0 0 0 A0A8C0NAI3 A0A8C0NAI3_CANLF COMM domain-containing protein COMMD7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892]; tumor necrosis factor-mediated signaling pathway [GO:0033209] NF-kappaB binding [GO:0051059] RLCKQFSALTEVLFHFLTEPK 1 8.1 0.96592 0.048461 0 0 0 0 0 0 0 0 0 0 0 0 0 7.355 0 A0A8C0NAP3 A0A8C0NAP3_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FASFAVLA;GSGLFSVLGTLLLPGLALLA;LEAVATLL;PESPCWLLAT 4 13.6 0.97254 0.048206 0 0 0 0 0 0 0 0 0 0 4.71661 0 0 0 0 A0A8C0NAP7 A0A8C0NAP7_CANLF TOG domain-containing protein TOGARAM2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904] microtubule binding [GO:0008017] ESEVNSVARDTTQ;LSSLRRNIGVILRKRANRASLP;LVLCENGLPGEDGLSSNGPRLE;PQAVERHVL;SLREQMGSRLQDLAAGQPQQ;SSSKFSHWESTSAPDGLPTK 6 9.7 0.87042 0.14186 0 8.04685 0 0 12.29 0 5.96461 11.5822 0 11.1798 11.278 0 5.28928 10.3132 0 A0A8C0NAQ1 A0A8C0NAQ1_CANLF Gasdermin A GSDMA Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; programmed cell death [GO:0012501]; pyroptotic inflammatory response [GO:0070269] membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471] wide pore channel activity [GO:0022829] EEKPEEKFTFI;LVESTMEHSFLQ;SIDHKEAVT 3 7.2 1.0023 -1.0007 0 0 8.85954 0 0 8.88038 0 0 10.8647 0 0 0 0 0 0 A0A8C0NAR8 A0A8C0NAR8_CANLF Tripartite motif containing 77 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EERRYLEGIEQESKD;NWVLGFCDDSWTM;SFVHVASS;SSSLICSFLSCSF;TSYANVNLRHLHVSPNHPDVV 5 15.7 1.003 -1.337 0 0 0 9.1384 0 6.19517 0 0 0 0 0 0 0 0 0 A0A8C0NAS0 A0A8C0NAS0_CANLF MAP6 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule cytoskeleton organization [GO:0070507] cis-Golgi network [GO:0005801]; Golgi-associated vesicle [GO:0005798]; microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017] DADAAAAVTTSYRQEFQA;LCCLARRWNQ 2 14.6 0.99131 -0.14782 11.308 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NAS8 A0A8C0NAS8_CANLF Catenin alpha like 1 CTNNAL1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737] actin filament binding [GO:0051015] LGPGRRRRRRPVGLRLRL;RPVGLRLRLGTRDQN 2 3.2 0.94266 0.10219 0 0 0 0 0 0 0 0 6.07585 0 0 5.98832 0 0 0 A0A8C0NAV2 A0A8C0NAV2_CANLF Metastasis associated 1 family member 3 MTA3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] NuRD complex [GO:0016581] chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] EGESDEREQSKLEVKVWDPN;PEMLLEGESDEREQSK;SILGKRNYSHHNGLDEL;TATGNVEAKVVCFY;TPNHTSLSILGKRNYSHH;YKPNPNQISASNGKPG 6 13.3 0.98782 -0.3993 7.33029 0 0 0 0 0 0 0 0 10.2832 8.24555 0 9.48724 14.5171 0 A0A8C0NAW0 A0A8C0NAW0_CANLF EI24 autophagy associated transmembrane protein Canis lupus familiaris (Dog) (Canis familiaris) macroautophagy [GO:0016236] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] DMLFNLLLQALFLIQGMF;QRRAQSIE;STKARGAA 3 10.1 0.98784 -0.4824 0 0 0 0 7.41709 0 0 0 0 11.8918 0 10.4332 0 0 0 A0A8C0NAW2 A0A8C0NAW2_CANLF Beta-2-microglobulin B2M Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] extracellular region [GO:0005576]; MHC class I protein complex [GO:0042612] FSCRVKHV;PALATAGFLA 2 16.8 1.0025 -1.3681 0 0 0 0 0 0 0 10.4408 0 8.00428 7.89609 0 0 0 0 A0A8C0NAY2 A0A8C0NAY2_CANLF Gamma-secretase-activating protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EKDLHVISCSINS;FQEEDYHQRLLIGLMVSELRE;PYSSVLTWNTE;SERTLLAAS;SVPIRFCVPLSFQN;SWRTHHLHP 6 7.2 1.0021 -1.2923 0 0 0 0 8.92205 0 0 11.9721 0 11.3803 0 10.5909 10.42 11.2668 0 A0A8C0NAZ3 A0A8C0NAZ3_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) SMURF1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin protein ligase activity [GO:0061630] AGGGDCRF;DPKWNQHYDLYV;GAAAGGGD;LDPKWNQHYDL;LSCFMEEPAPYTD;QPLPLPSEGSVEDEEL;SLQQPQAGHCRIEV 7 9.6 1.003 -2.5478 8.10559 0 0 0 9.48 9.41962 0 0 5.90169 0 0 9.97728 0 0 9.33237 A0A8C0NAZ9 A0A8C0NAZ9_CANLF FDX-ACB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] rRNA (uridine-N3-)-methyltransferase activity [GO:0070042] FVPGKIEPFKSYSLY;PCYVHDISFWLDKKKEFDELEFHTV 2 7 0.93738 0.089422 0 0 0 0 0 7.07724 0 0 0 0 0 0 6.97338 9.27216 0 A0A8C0NB08 A0A8C0NB08_CANLF SLAM family member 9 SLAMF9 Canis lupus familiaris (Dog) (Canis familiaris) cell surface [GO:0009986]; membrane [GO:0016020] KGLLLLLLFAIL;VTYSWISRDNCRDTV;YSWISRDNC 3 9.4 0.98148 -0.24881 0 0 0 0 0 0 0 0 0 0 0 3.25627 0 0 8.74409 A0A8C0NB17 A0A8C0NB17_CANLF Importin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737] small GTPase binding [GO:0031267] AMLLEHAG;CQDTDEEEEEEDQAEYDAM;DAIRVRILCCLTFLVKVKSKALL;DEEEEEEDQAEY;EALGQFCCAL;FYSLRTLTTMA;GRRRLLGGPSTHTCHLCSSL;IMEHLREFLLAGHGDLQPVQ;LTFLVKVK;VGSPGLLFYS 10 10.5 1.0034 -1.5469 0 0 7.65084 0 7.76102 6.5282 7.53667 10.5105 0 0 0 2.94265 0 0 11.7636 A0A8C0NB25 A0A8C0NB25_CANLF Tripartite motif containing 55 TRIM55 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DEDEEGEGEEGEGEGGGGEGEGEEG;EDEDEEGE;EIDFYREDEDEEGEGE;FYREDEDEEGEGEEGEGEG;HVRALIKK;PVVILPCQHNLCRKCASDIFQASNP;QIGFEDPPLQVQAA;VLVGSNDRVQG 8 19.8 1.0035 -1.5434 7.9344 8.62026 8.4589 0 8.03474 0 9.01686 0 0 0 0 10.364 6.10578 0 0 A0A8C0NB38 A0A8C0NB38_CANLF Macro domain-containing protein PARP14 Canis lupus familiaris (Dog) (Canis familiaris) ISGIATKQRR;NFCYRLRGSRIHISGIATKQRRK;VLISGDVICFQADVIVNTV 3 6.6 0.98537 -0.44107 0 0 3.54622 0 0 11.5332 13.2113 0 0 0 12.477 0 13.2429 0 0 A0A8C0NB40 A0A8C0NB40_CANLF FCH and double SH3 domains 2 FCHSD2 Canis lupus familiaris (Dog) (Canis familiaris) neuromuscular synaptic transmission [GO:0007274]; regulation of actin filament polymerization [GO:0030833] neuromuscular junction [GO:0031594]; recycling endosome [GO:0055037] lipid binding [GO:0008289] QNHRRPAEKIEDVE;RIGVFPSVL;WATRVAREHKNI 3 4.7 0.98624 -0.45276 7.77498 0 13.0338 0 0 0 0 0 8.82788 0 0 0 0 0 0 A0A8C0NB62 A0A8C0NB62_CANLF Chromosome 12 C6orf163 homolog C12H6orf163 Canis lupus familiaris (Dog) (Canis familiaris) ADFILPERKKTPSSLIIQE;DILDKEEQFQEAVLKE 2 10.6 0.99314 -0.14314 0 0 0 10.4627 0 0 0 0 0 6.7021 0 0 0 0 0 A0A8C0NB66 A0A8C0NB66_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LHGPSAFRP;LLSPSQAVLLYQQFYILKSCLQYSK 2 5.4 1.0041 -1.1018 0 0 0 0 0 0 9.7958 0 0 0 0 0 0 0 0 A0A8C0NBB0 A0A8C0NBB0_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AGDQGNEDHETPMDTDSNDSEMASP 1 3.6 0.97497 0.035538 0 0 0 0 0 0 0 8.75869 0 0 0 0 0 0 0 A0A8C0NBB3 A0A8C0NBB3_CANLF RNA helicase (EC 3.6.4.13) DDX43 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] CDRERALENFKTGKVRI;FLESISSQDKVIV;LSSDLILQHVSVE;QVDSWRKENNNIMCDDLKEGEKRR;RKKWEDLPPIKK 5 12.2 0.98778 -0.48481 0 0 0 7.97177 0 0 0 8.13597 0 0 0 6.43087 0 0 0 A0A8C0NBB7 A0A8C0NBB7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;IPWTFFRQL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RMGNINKAGNNKCW 6 5.2 0.98507 -0.25795 0 0 0 0 0 0 10.8893 0 0 0 0 0 0 0 0 A0A8C0NBC3 A0A8C0NBC3_CANLF Cadherin-like beta sandwich domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DENTEKSQVPLNATEN;ELNPEFNPKIKDYYSEVPF;ETELRLHQHILTQHRYT;IGDSTNRGIMY;LRRTGKPPS;LSCSPSASRQPVVLLSAFQIP;YSYYPQFWMSPAL 7 11.2 0.94971 0.049735 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85846 0 A0A8C0NBC6 A0A8C0NBC6_CANLF LRP2-binding protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EKAFYWHSEACGNGNLESQ;KDEATAKLYYSKACRLNPALAE;SEACGNGN 3 12.7 1.0031 -0.78427 0 0 0 7.91827 0 6.90231 0 0 12.6511 0 0 0 0 0 0 A0A8C0NBE1 A0A8C0NBE1_CANLF Catenin alpha like 1 CTNNAL1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] LADRVVIKQIITSRNKRIIIYNLRK;NWDLKEEINVACIEAKQAGE;TKKSDKTLQA;VGGAGPSGFAF;VLLLADRVVIKQIITSRNKRIII 5 38.8 0.98519 -0.43088 0 0 0 0 0 7.80768 11.0835 0 0 0 8.73698 0 0 0 5.53993 A0A8C0NBF3 A0A8C0NBF3_CANLF Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) DEUP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] KAQFSKLTNSFE;LQELMEQIDIMVSNKKLDW;LVSDDEVFPLVAGRMRVGNSTAWPS;QETNQIQQFLD;RGVPAKGP;SEITDVKSM 6 12.6 1.0022 -1.3923 0 8.19545 0 0 0 10.5039 0 0 0 0 0 0 0 0 0 A0A8C0NBF9 A0A8C0NBF9_CANLF Colony stimulating factor 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] ERPSAAPGDHQKPG;FAFRLLVPSVILVLLAVGGLLLYR;GGRGGGGG;LLVPSVILVLLAVGGLLL;VGGLLLYRRRRRSHREPQAA 5 5.9 0.9864 -0.41822 0 0 0 0 9.55739 0 0 5.55115 4.55839 0 0 0 0 0 0 A0A8C0NBK2 A0A8C0NBK2_CANLF Coiled-coil domain containing 71 CCDC71 Canis lupus familiaris (Dog) (Canis familiaris) GLRDDGFQPT;GVYPAMRL;KAKAKVVRAKSKVKAVRAKTK;KGPKCLTHRAP;PTPAATSPP;SQDLSATEAQLVAFLQ;SQDLSATEAQLVAFLQGLRDDGF 7 14.3 1.003 -1.6642 0 0 7.88789 0 0 0 11.6949 0 11.1099 9.36481 7.57039 0 0 11.6907 9.46589 A0A8C0NBL3 A0A8C0NBL3_CANLF Lipase maturation factor LMF2 Canis lupus familiaris (Dog) (Canis familiaris) protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789] LLLRPLRNLFVYLLLWA;TRARPEPAAPATPWPRP;WLKMVILPTM 3 5.9 0.9768 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.32029 A0A8C0NBL6 A0A8C0NBL6_CANLF Neuropilin Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; axon guidance [GO:0007411]; regulation of plasma membrane bounded cell projection organization [GO:0120035] membrane [GO:0016020] heparin binding [GO:0008201]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor receptor activity [GO:0005021] CGKIAPSP;EDRDCKYDYVEV;ENYNFELVDGVK;FKCMEALGMES;HPYINEWLQ;RIDISSNGE;RPTVIDSTIQSEFP;SGVIKSPGFPEKYP 8 10.4 0.99836 -3.2968 7.38172 0 0 7.46948 7.53792 9.3497 0 9.57926 0 0 9.39949 6.13367 0 6.7237 10.2456 A0A8C0NBM8 A0A8C0NBM8_CANLF Rho guanine nucleotide exchange factor 19 ARHGEF19 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] GTPPPLQGLLWP;VPQAHVEEIGS 2 2.9 0.98882 -0.52312 0 0 0 0 0 6.6939 0 12.6019 0 0 0 0 0 0 0 A0A8C0NBN3 A0A8C0NBN3_CANLF Securin PTTG1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059] cytoplasm [GO:0005737]; nucleus [GO:0005634] AQAALPKVARK;QAALPKVARKA;VPASDDTY 3 10.5 0.99127 -0.19494 16.4737 0 0 0 0 8.58871 0 0 0 0 11.2046 0 0 0 0 A0A8C0NBP3 A0A8C0NBP3_CANLF Vesicle tethering protein Uso1/P115-like head domain-containing protein USO1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle fusion with Golgi apparatus [GO:0048280] Golgi membrane [GO:0000139] DDEEDEDEDD;ESGDQDDEEDEDE;FHDRFKNF;FTEIFIKQQEN 4 3.6 1.0028 -1.0093 0 3.92913 0 0 0 7.48736 0 0 0 0 0 4.47223 0 8.87958 5.45062 A0A8C0NBP6 A0A8C0NBP6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LENLGSYLVHAENNYLNPCEKRIG;TKHLRIHSKEKP;VARPLLVVHI 3 4.1 0.99455 -0.56102 0 3.42492 6.22439 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NBQ4 A0A8C0NBQ4_CANLF Non-specific serine/threonine protein kinase Canis lupus familiaris (Dog) (Canis familiaris) AGEWFLDGQAL;AWFECETSIPSVRP;EAREVTVTQPLQ;EDEDTYTCD;HLQRRREAMRA;KQSDRGLYTCTASNLV;LAVHGPIHTLT;LVIKDVQPEDED;LVVVREPTMPFKKRLQ;RPNVDVRWLKDGV;SPSDAAVSWFRDGALLQ 11 4.8 1.0021 -1.2972 8.41414 0 0 9.18733 0 6.9305 6.08423 0 0 0 0 0 8.54732 11.6919 0 A0A8C0NBQ7 A0A8C0NBQ7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CGEEGCSDPGGSVSVA;LAKPPPVL;TQKDTCGEEGCSDPGG 3 6.4 0.98756 -0.48617 0 7.63916 0 0 0 0 0 0 6.47299 0 0 0 4.82812 11.444 4.45477 A0A8C0NBU0 A0A8C0NBU0_CANLF Wnt ligand secretion mediator WLS Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139] Wnt-protein binding [GO:0017147] DIQLVGIHQNGGFTK;DIQLVGIHQNGGFTKVWF;EGLIFRFKFLM;GMWNLYVFAL;HYEGLIFRF;VGPTTAVSYMSVKC;YSIWTTDV 7 11.6 1.0028 -1.5374 9.72566 0 0 0 7.71081 8.96584 0 0 9.63341 0 9.36584 0 0 0 0 A0A8C0NBU6 A0A8C0NBU6_CANLF BRICHOS domain-containing protein TNMD Canis lupus familiaris (Dog) (Canis familiaris) VTRTEIFRS 1 3.5 0.99127 -0.13627 0 0 9.52503 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NBU9 A0A8C0NBU9_CANLF SMB domain-containing protein VTN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; immune response [GO:0006955] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix binding [GO:0050840]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] AAFTRINCQGKTYLFKGSQYWRF;CSYYQSCCEDYV;DTYNYDDYDM;KGIPDNVDAA;LVPATCEPIQS;QCDELCSYYQSCCE 6 15.1 1.0014 -0.91559 0 8.96864 0 6.02146 0 0 9.82037 0 3.8338 8.42593 8.70473 0 0 0 0 A0A8C0NBW0 A0A8C0NBW0_CANLF Peptidase S1 domain-containing protein LOC478220 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] ATSWPREPQTGAPPSASR;PREPQTGAPPSASRRPD 2 6.8 0.93713 0.097713 0 9.58539 0 0 0 11.3368 0 0 0 0 0 0 0 0 0 A0A8C0NBW8 A0A8C0NBW8_CANLF Ig-like domain-containing protein CADM3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GEAISSTVWSS;GIVAFIVFLLLILLI;HIHRCTYM;IVCSVNHESLKGADRSTS;VAFIVFLLLILLIFLGH;YHAIIGGIVAFIVFLLLILL 6 10.4 1.0017 -0.96122 0 0 0 9.13855 0 5.75662 9.95768 5.54282 0 7.77834 7.77466 0 0 0 8.52431 A0A8C0NBX0 A0A8C0NBX0_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVHSIYALESSVLLAMAFD;RLLRLLHLGK 2 9.8 0.99957 -0.61146 0 0 0 5.06596 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NBY4 A0A8C0NBY4_CANLF "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] metal ion binding [GO:0046872]; superoxide dismutase activity [GO:0004784] YMACKKGATIWESY 1 4.2 0.93734 0.060945 0 0 0 0 8.03469 0 0 0 0 0 0 0 0 8.34824 0 A0A8C0NBY7 A0A8C0NBY7_CANLF Placenta associated 8 B PLAC8B Canis lupus familiaris (Dog) (Canis familiaris) AADMNECCL;MCDCFSDCG;NWQTGMCDCFSDCGVCLCGTF 3 26.5 1.0027 -1.347 11.5947 3.93471 0 0 0 0 11.5656 0 11.6222 0 0 0 0 0 0 A0A8C0NC02 A0A8C0NC02_CANLF Potassium voltage-gated channel subfamily H member 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of membrane potential [GO:0042391] monoatomic ion channel complex [GO:0034702] delayed rectifier potassium channel activity [GO:0005251] DEVVAILGKGDVFGDVFWK;FVVSGSLEVI;KRIVFRKISDVKREEEERMKRKNEA 3 8.9 0.9477 0.085098 0 0 0 0 0 0 5.9634 0 0 0 0 0 0 5.34462 0 A0A8C0NC03 A0A8C0NC03_CANLF Gap junction protein Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] LLSLVFKLAI;LLVMLHVAYREERERRHRL;PGVGKSGW;PLSGGGPG;SGALAAAL 5 8.1 1.0036 -1.5982 11.4923 10.7085 11.2699 0 0 0 0 5.25867 7.09856 11.2961 0 0 12.1234 11.0866 0 A0A8C0NC09 A0A8C0NC09_CANLF Catenin delta 2 CTNND2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; dendritic spine morphogenesis [GO:0060997] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] cadherin binding [GO:0045296] AEDIKHNQVPAQPVPQEPSRKDYE;LERCKLGSETGSMSSI;REPFAPSLGS;SLGSAFHLPDAP;SSEIDSKTVENCVCILR;STAPSSPGVDPGPLQRAGSQ;STIGTYATL;VDLLDHRMTEVHR 8 8.9 1.0021 -0.68876 0 0 11.6829 0 8.47881 6.79286 8.75138 10.9349 0 0 7.20408 0 0 7.55536 0 A0A8C0NC15 A0A8C0NC15_CANLF GMP reductase (GMPR) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase) GMPR2 GMPR Canis lupus familiaris (Dog) (Canis familiaris) purine nucleobase metabolic process [GO:0006144]; purine nucleotide metabolic process [GO:0006163] GMP reductase complex [GO:1902560] GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872] FIRVTQQLLLVRY;KLDFKDVLLRPKRSTLKSRSE;RVTQQLLLVR;SEVDLTRSFSFRNSK 4 13.5 0.99774 -0.089497 0 0 0 0 0 0 11.689 0 3.80962 0 0 0 0 0 7.96607 A0A8C0NC41 A0A8C0NC41_CANLF Hedgehog acyltransferase HHAT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LDGLTPPPLPRCVSTM;LHTLISFCVAQ;SKLSGGLLML;YPVFHNGPILSFPEFIAKVQ 4 11.2 0.98981 -0.26218 9.29902 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NC51 A0A8C0NC51_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NGHQTLLGPEDPLVHS 1 7.8 0.9851 -0.23693 0 0 0 0 0 9.16895 0 0 0 0 0 0 0 0 0 A0A8C0NC55 A0A8C0NC55_CANLF Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) Canis lupus familiaris (Dog) (Canis familiaris) chemokine-mediated signaling pathway [GO:0070098]; inflammatory response [GO:0006954] early endosome [GO:0005769]; membrane [GO:0016020]; recycling endosome [GO:0055037] chemokine binding [GO:0019956]; G protein-coupled receptor activity [GO:0004930] DDFWDEFNESYELNYNYSDM;LAVGSTLFSVVVPILAPG 2 11.5 0.9898 -0.21233 5.38919 0 0 0 0 0 0 0 0 0 0 0 0 0 3.44374 A0A8C0NC57 A0A8C0NC57_CANLF Vacuolar protein sorting-associated protein 35 VPS35 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" "cytosol [GO:0005829]; late endosome [GO:0005770]; retromer, cargo-selective complex [GO:0030906]" EDVVSLQVSL;LNQLIQKI;SRQDMPSEDVVSL;YQLAFRYKENSKVDDK 4 5.2 1.002 -0.76822 0 0 0 0 0 0 8.07778 8.90159 9.52855 0 0 0 7.61919 0 0 A0A8C0NC76 A0A8C0NC76_CANLF OFD1 centriole and centriolar satellite protein Canis lupus familiaris (Dog) (Canis familiaris) EPKSAFSIGDKRVQR;LLPHYRSPPP;QDKTEFSNPDKQ;SLFQKQMELQ;YKSLISGFDK 5 4.8 0.99503 -0.15642 0 0 0 0 0 0 6.1565 0 10.8339 0 0 0 6.38007 0 0 A0A8C0NC84 A0A8C0NC84_CANLF G-protein coupled receptors family 1 profile domain-containing protein NPFFR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] GEGPGCGH;PSQPPNSSWPPSQN 2 5.1 1.0033 -1.1044 0 7.30314 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NCA6 A0A8C0NCA6_CANLF Glucosaminyl (N-acetyl) transferase 2 (I blood group) GCNT2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] DMEDKHGGCHG;FPNAFLASRMEP;KDYLLQSHYITSPLSE;LMVYHSQLHLPRSL;VGSVPCKDYLLQSHYITS 5 14.7 0.58716 0.37131 12.4814 7.07532 0 0 7.52097 0 0 0 0 0 0 0 0 0 0 A0A8C0NCB1 A0A8C0NCB1_CANLF Hedgehog acyltransferase HHAT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADFRLTQE;LDGLTPPPLPRCVSTM;LHTLISFCVAQ;VGDSWPVP;YPVFHNGPILSFPEFIAKVQ 5 7.9 1.0024 -1.7901 0 0 0 0 9.61206 0 0 0 6.53528 6.20122 0 0 0 0 0 A0A8C0NCD9 A0A8C0NCD9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TLNVNRLNDSIK 5 6.3 0.9919 -0.27789 0 0 0 0 0 0 0 8.09945 0 0 0 0 0 0 0 A0A8C0NCE0 A0A8C0NCE0_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AQAIMSELHTI;GVSHLHGHTCAGQADPYNPKI;KYFWSLMYI;VLIDRKMST 4 6.1 1.0032 -1.1201 0 0 0 7.99594 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NCE3 A0A8C0NCE3_CANLF NIPA like domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] AGQGGHSYLK;SILGSTVM;VISLVLILIVAPKK 3 7.8 0.99174 -0.55069 0 0 0 0 0 0 0 0 0 0 0 0 9.28873 0 0 A0A8C0NCE8 A0A8C0NCE8_CANLF Actin-related protein 2/3 complex subunit ARPC1A Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779] AAGHDCCPMLFNYDDRGCL;SRSGALTVYGDVSGDQ 2 8.8 0.98507 -0.23624 0 0 0 0 0 0 0 0 0 0 0 0 0 8.77811 0 A0A8C0NCF0 A0A8C0NCF0_CANLF NYN domain and retroviral integrase containing Canis lupus familiaris (Dog) (Canis familiaris) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; RNA-DNA hybrid ribonuclease activity [GO:0004523] AEKASDKAENR;EEGHKHVLIV;EVPSATTKPAAQGVPTTQKAAEGLP;GAQGGGQW;PQALHCAFL;QKEGPGYGVGAFQNKSLE;RVSKAWLIRWSLLV;SVKDKTSPG;VSALGVCPPWKAWTPGPA;YCFYREDEWC 10 6.9 0.99899 -3.2532 5.59003 11.4419 0 0 8.37265 8.90536 0 0 7.99424 0 0 0 10.3393 0 4.35966 A0A8C0NCG7 A0A8C0NCG7_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] DINCVKHIIYVDNKTIN;EALIEITKDIRALLKRK;KDIRALLKRKR;SEENEMQPN;TYGCRIGYSSPLTLSDQEIMDRIY 5 9.3 0.99277 -0.16894 0 0 5.47884 8.8657 0 5.00675 0 0 0 0 0 0 0 0 8.39498 A0A8C0NCH6 A0A8C0NCH6_CANLF PDZ domain-containing protein STXBP4 Canis lupus familiaris (Dog) (Canis familiaris) KSIITRAKL;SPLSSLSCHQQCTSTSS 2 5 0.98761 -0.3669 0 0 9.40137 0 0 0 0 0 10.1653 11.7668 11.5111 11.4153 0 0 13.3065 A0A8C0NCI5 A0A8C0NCI5_CANLF WW domain-containing protein WWC2 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; negative regulation of organ growth [GO:0046621]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737] kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090] DLELDLQASLTR;LPKRRVIHLLG;RLEAERQRLEEELLSVRGPPS;SNLAEKVRL;TLVDKETNTDEAGDAGV;VKRTVCQPVLRRTAP 6 7.9 0.99346 -0.073932 0 9.20584 0 0 3.99919 0 0 0 0 0 3.27192 5.03822 7.0167 0 11.4844 A0A8C0NCJ9 A0A8C0NCJ9_CANLF Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein THA1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520] lyase activity [GO:0016829] AMAEAVVGDDDYGEDPTVRE 1 5.1 0.99585 -0.092002 0 14.3076 0 0 0 0 13.4818 13.7018 14.3197 0 13.3325 10.8387 13.3501 0 0 A0A8C0NCK9 A0A8C0NCK9_CANLF Interleukin 13 receptor subunit alpha 1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] DTNYTLYYWHSSLGK;GAIIVLLLYLKRLKII;IVAGAIIVLLLYLKRLKIIIFP;IVLLLYLKRLK;IVLLLYLKRLKIII;LATPVIVAGAIIVLLLYLKRLKI;LFFQNGNLYVQ;LLLYLKRLKIII;TPVIVAGAIIVLLLYLKRL;VIVAGAIIVLLLYLKRLKI;VLLLYLKRLKIIIF;YDIYEKQTKEE 12 16.1 0.98972 -0.27368 4.76437 0 0 0 0 8.98362 6.33883 8.87249 0 4.33899 0 0 3.90525 0 0 A0A8C0NCL6 A0A8C0NCL6_CANLF Elongator complex protein 1 ELP1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] ATFSRHKKRLLVVRELKEQAQ;EFDEQGRELQK;ENGEDQEI;KMETNYQRFTIDKYLKRYEKAIG;LAGGQILK;LLVDVNELYDHSL;LVCLMWDLVTPYR;LVDVNELYDHS;PAGLVFARCG;TQEKPNQQDIVFFEK;WNADSTVLAVWLEDLQRGENCTL 11 11.2 1.0017 -2.6372 11.3175 7.53799 5.68773 0 0 0 0 0 7.35165 0 0 0 13.1738 13.248 9.76296 A0A8C0NCL7 A0A8C0NCL7_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] AVLKFTTEIH;IGGVAVGIVLLLVLAGIGLFIH;PGPRACLALLWG 3 4.8 0.95302 0.05044 0 0 0 0 0 0 0 0 0 0 0 6.21979 0 0 0 A0A8C0NCN6 A0A8C0NCN6_CANLF "Discoidin, CUB and LCCL domain containing 1" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGLELESKGVRQQPN 1 1.8 0.89907 0.12376 0 0 0 0 0 9.63648 10.4615 0 0 0 0 0 0 0 0 A0A8C0NCP3 A0A8C0NCP3_CANLF "Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP" SART1 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]" U4/U6 x U5 tri-snRNP complex [GO:0046540] AADVINPMALRQRE;CQNKGLLETTVQKVA;FKKTKRRVKKIRKK;RRVKKIRKKEKEVVVRAD;SDEEEAGGPQSGSP;TKRRVKKIRKKEKEVVVRA;VLEEDEAELELQ;VTFKKTKRRVKKIRKK 8 10 0.98649 -0.4194 5.85999 7.04843 8.79263 0 0 0 0 4.75125 6.53964 0 0 5.4273 6.38398 0 7.84185 A0A8C0NCR8 A0A8C0NCR8_CANLF Family with sequence similarity 122A PABIR1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic G2/M transition checkpoint [GO:0044818] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein serine/threonine phosphatase inhibitor activity [GO:0004865] AEGGGSGAGGGLRRSN;GIGKQCFSPSLQ 2 9.8 0.93255 0.099673 0 0 0 0 0 0 0 0 8.01542 0 0 0 9.6974 0 0 A0A8C0NCV1 A0A8C0NCV1_CANLF Visinin-like protein 1 VSNL1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] QDGGHGAG 1 4.1 1.0044 -1.1044 0 9.29228 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NCV9 A0A8C0NCV9_CANLF "Corin, serine peptidase" CORIN Canis lupus familiaris (Dog) (Canis familiaris) peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ASRRCDGQADCDDDSDEENC;CDDDSDEENCGCKERDLWECPT;CDGQADCDDDSDEENCGCKER;CDGYDDCGDL;CIPSTFRCDGDEDCRDGTDE;DCDDDSDE;GMDEKNCSFCHDDELE;GYDDCGDLSDE;HATPTPLF;HNDCGDWSDEAQCNCSE;KSFLMAHRSAVE;LDSSDEWDCVTL;LQEGEVRIISLEQCQAYFDMK;PECVGDGDSHGLL;PLVTDGEVPVSEI;RCDGQADCDDDSDEENC;RCDGQADCDDDSDEENCGC;VICDGFPDCPDGMDE;VLGMVNASWPDFLA;VLIPCICALIVLLV;YKYLMFFACTVLV;YSLVCDGYDDCGDLSDEQNCAC 22 23.6 1.0004 -2.8163 10.0143 10.3151 0 8.95254 7.74645 0 0 9.67016 0 11.2507 0 4.88889 6.22137 10.6804 0 A0A8C0NCW0 A0A8C0NCW0_CANLF Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) APBB1IP Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AQAKADKIKLALEKLKEAKVKKLVV;HENVVEVLSDWT;KIKLALEKLKEAKVKKLVVKVH;PPPEPLSQEEEAAQ;SSPATAARARGLGGGF 5 10.3 0.99416 -0.073702 0 0 0 5.43276 0 0 6.33937 10.1221 0 0 0 3.80962 0 0 0 A0A8C0NCW2 A0A8C0NCW2_CANLF Solute carrier family 35 member F1 SLC35F1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GGGGGGGSL;IENLPAEGG;ILLFLVYTTTLA 3 6.8 0.9856 -0.23242 6.84725 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NCX1 A0A8C0NCX1_CANLF PH domain and leucine rich repeat protein phosphatase 1 Canis lupus familiaris (Dog) (Canis familiaris) EALRKMPHIKHVDLRLNVIRKLI;ESFSLSPSAESVSDRLDP;EVLHCERNQLVTLNICGYF;GEATRRLEADEKPLQIQNDY;LLLRRGRLKRNLSAGRRRLVVLLV;LTELNVSC;RTSVEVLDVQ;TEDSFCCCELG 8 8.2 1.0044 -1.0956 9.49039 0 0 7.19466 7.0148 0 0 6.91886 0 3.95243 4.99077 0 0 6.38974 0 A0A8C0NCX2 A0A8C0NCX2_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FHKIRSRIVQRTPKTKKSKKFRK;KIRSRIVQRTPKTKKSKKFRKKNSF;NNKLILAISVTVVVMILIIV 3 5.6 0.97876 0.035538 0 7.91576 0 0 0 0 0 0 0 0 0 0 2.88276 0 0 A0A8C0NCY0 A0A8C0NCY0_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP5 Canis lupus familiaris (Dog) (Canis familiaris) peptidyl-prolyl cis-trans isomerase activity [GO:0003755] DRNEPFVFSL;IVSWLEMEYGLSEKESKASESFL;QDAKEEASK 3 9.2 1.002 -0.68777 0 0 0 0 0 0 10.0119 0 11.0469 0 0 0 0 0 0 A0A8C0NCZ5 A0A8C0NCZ5_CANLF PTTG1 interacting protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EERRIRQEERRAEMKSRHDEIRKKY;GAMGSWGP;GSGARCLQ;LLAVAVCCCCCCC;VCCCCCCCR 5 14.4 1.0021 -1.2374 2.64413 0 4.38391 0 0 0 0 11.1163 11.9862 0 0 0 0 0 0 A0A8C0NCZ6 A0A8C0NCZ6_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] AKDLVRKLIVLDPKKR;ALKVLKKTIK;AYLHENGIVHRD;GGGDGGGG;GGGGDGGG;GGGGGGGE;GGGGGGGG;LRLPLPLPPGLRLPPRLRL;PGGGGGGG;PGLRLPPRLRLPPRLRLRLP 10 14.6 1.0025 -0.72291 0 0 0 6.30001 6.61628 5.47508 8.53329 9.77038 0 0 8.22545 0 0 0 0 A0A8C0NCZ9 A0A8C0NCZ9_CANLF F-box domain-containing protein FBXW4 Canis lupus familiaris (Dog) (Canis familiaris) GILLKWRCSQMPWMQLE;TIQTEDRVW 2 4.6 1.0026 -0.75799 0 0 0 7.60518 0 0 5.7658 0 0 9.8687 0 0 0 0 0 A0A8C0ND05 A0A8C0ND05_CANLF Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] mitochondrion [GO:0005739] ATP binding [GO:0005524]; ubiquitin-like modifier activating enzyme activity [GO:0008641] GKNRAEVSQPRLAE;IANALEMWIL;VLGPYTFSIC 3 3.3 0.98894 -0.22689 0 0 0 0 0 0 0 0 0 0 0 0 8.25049 0 0 A0A8C0ND09 A0A8C0ND09_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MNEKGEITTNT;RRELIWIRAELNEIETR 2 2.4 0.97706 0.046227 0 0 0 0 0 0 9.25772 9.96047 0 0 0 0 0 0 0 A0A8C0ND10 A0A8C0ND10_CANLF UBX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] NF-kappaB binding [GO:0051059]; ubiquitin binding [GO:0043130] EQFRLEQIRKEQLE;LNQNFMLIITHRE;NFITWAWDL;VAQTIRTQE 4 7.8 0.99248 -0.032827 0 0 0 0 0 0 0 8.33275 0 0 0 0 9.98741 0 0 A0A8C0ND12 A0A8C0ND12_CANLF Hydroxysteroid 17-beta dehydrogenase 6 HSD17B6 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" DTLRRELRHFGV;RHFGVKISIVEP 2 6 0.99028 -0.26687 0 0 0 0 0 0 0 0 0 0 0 0 0 8.41709 0 A0A8C0ND25 A0A8C0ND25_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;GVLPNSFYEASIIL;LKLFGKIETDGV;MDAFLESHKL;MNEKGEITTNT 5 5.4 0.92204 0.11245 0 0 0 0 0 0 5.56246 9.26533 5.81029 0 0 0 0 0 0 A0A8C0ND36 A0A8C0ND36_CANLF Galectin domain-containing protein LGALS4 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] mitochondrion [GO:0005739] "carbohydrate binding [GO:0030246]; delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity [GO:0051750]" ASEILQPQ;FVAGAHPG;GQFFDLSIR;RYQETFSVIE;SVYIQGITSEHMRRF;SWNLRNLITRYQ 6 9.6 1.0041 -1.9934 0 11.4664 0 5.792 6.49422 0 0 0 9.68083 0 0 0 0 12.9172 3.75969 A0A8C0ND38 A0A8C0ND38_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RLRPILLKDKRVNQ 5 5.7 0.93996 0.060769 0 0 0 0 0 0 0 0 0 0 3.93329 0 0 0 0 A0A8C0ND42 A0A8C0ND42_CANLF Olfactory receptor OR2AV12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GKFSIQNRFAR;SLRNREVVDSMKKVMG 2 8.3 0.94783 0.084724 0 0 0 0 0 0 0 0 9.67633 0 0 0 0 0 10.1738 A0A8C0ND58 A0A8C0ND58_CANLF Armadillo repeat-containing domain-containing protein ARMC12 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell growth [GO:0030307] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DYVHPQLRRVMPALMEI;LLSYLAQKNDLLYDI 2 8.7 0.93939 0.1001 0 0 0 0 0 0 0 0 7.87067 0 0 2.72004 0 0 0 A0A8C0ND77 A0A8C0ND77_CANLF Ceramide synthase 4 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] GSGDGDSP;VGAPPAERG 2 2 1.0029 -1.9086 0 0 0 0 0 0 0 8.77307 8.09914 0 0 0 0 0 0 A0A8C0ND81 A0A8C0ND81_CANLF Period circadian protein homolog 2 (Circadian clock protein PERIOD 2) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AEMHSSSPAQMKAVPVEK;EVPAPLHGGP;GAVAAAPV;LKSKRAKPRDSSE;LNEDVFSAPSL;TSQCSYSST 6 5.6 1.0031 -1.5914 6.3338 0 0 0 0 0 0 0 0 0 10.3411 0 6.94673 0 13.0275 A0A8C0ND97 A0A8C0ND97_CANLF MAGE domain-containing protein LOC492173 Canis lupus familiaris (Dog) (Canis familiaris) EAQRRAQNPVD 1 3.2 0.98435 0.035491 0 0 0 0 4.25671 0 0 0 0 0 0 0 0 0 0 A0A8C0NDA2 A0A8C0NDA2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;LNKIRANRIQQYIKKIIHQ;MDAFLESHKL;MNEKGEITTNT 4 7.1 0.95366 0.04941 0 0 0 0 0 0 0 6.77281 6.26281 0 0 0 0 0 0 A0A8C0NDA3 A0A8C0NDA3_CANLF SURP and G-patch domain containing 2 LOC100685713 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] DEDEEDEDEDEEGTEEASTPGG;DEDEEGTEEASTPGGA;EDEEDEDEDEEGTEEASTPGGA;EFEDEPPQHEA;IDQLVTRIV;NLGFQMLQ;PEEDDEDEED;PEVMPEEDDEDEEDEDEDEEG;QEYNFGPSALLGDFGSSRLIEKE;SLKKRLLPGRRRGLLRTQGLR 10 9.3 1.0033 -2.394 0 10.7124 8.99093 8.67507 10.969 0 0 0 0 9.13042 4.45556 6.26245 9.56487 9.39579 9.44638 A0A8C0NDA9 A0A8C0NDA9_CANLF Cartilage oligomeric matrix protein COMP Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] calcium ion binding [GO:0005509] CDPDADGDGVLNEQD;DACDDDDDNDGVP;DSDQDQDGDGH;GDACDDDDDND;GPQMLRELQE;GVGDACDNCPQKSNAD;HDFVGDACDSDQDQDGDGH;QDSDHDGQGDACDDDDD;QDSDHDGQGDACDDDDDND;QGDACDDDDDNDGVPDSWDN;SAQQDSDH;SAQQDSDHDGQGDACDDDDDN;SNADQRDVDHDFVG;VGDACDSDQDQDGDGHQDS 14 13.9 1.002 -1.8348 9.88984 0 4.72705 0 6.30947 3.10822 4.96952 9.74019 0 3.20945 0 0 7.58045 0 0 A0A8C0NDB8 A0A8C0NDB8_CANLF UV excision repair protein RAD23 RAD23B Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome complex [GO:0000502] damaged DNA binding [GO:0003684]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130] AANFLLQQNFD;GGGGGGSG 2 4.7 0.98435 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 14.0111 0 A0A8C0NDC6 A0A8C0NDC6_CANLF REC8 meiotic recombination protein Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] cohesin complex [GO:0008278]; nucleus [GO:0005634] DIEVLREAQ;RRRQLLFWDKETQISREKFQEQLQ 2 5.9 0.98972 -0.20224 0 0 0 0 5.73944 0 0 0 9.65306 0 0 0 0 0 0 A0A8C0NDD1 A0A8C0NDD1_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] KEWQQLDPTQRMLYRDVMLE 1 14.6 0.95418 0.050575 0 0 0 0 0 0 0 8.94717 0 0 0 0 0 0 0 A0A8C0NDD5 A0A8C0NDD5_CANLF AT-hook containing transcription factor 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AKTTDFSLNSPEKDHQ;DIGQILLIDLCLD;ELEAGDSAASNV;TIYLLLDIMYSFP 4 2.6 0.79474 0.22282 6.59643 8.05588 0 0 0 0 0 0 9.62859 9.29859 0 0 0 8.67288 9.19786 A0A8C0NDE8 A0A8C0NDE8_CANLF ACB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] fatty-acyl-CoA binding [GO:0000062] GAGAGGGRVRGAAAAGLVAMSL 1 12.2 0.98492 -0.24044 0 0 0 0 0 0 0 0 10.2166 0 0 0 0 0 0 A0A8C0NDG7 A0A8C0NDG7_CANLF DUF4097 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASKHEKWIKADA;VNSEVHVQEMTEVHKEDGVI 2 12.1 0.94215 0.1009 0 0 0 8.02636 0 0 0 0 0 0 0 0 0 7.18696 0 A0A8C0NDH4 A0A8C0NDH4_CANLF LEM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020]; nucleus [GO:0005634]; organelle envelope [GO:0031967] AAEPPPQQP;GGGGGGGG;QQGGGADA;RPVYLKKLKKL 4 3.8 1.0027 -1.3248 0 0 0 0 10.8626 5.23013 0 0 0 0 12.6308 0 0 0 0 A0A8C0NDH8 A0A8C0NDH8_CANLF SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) UBE2I Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925] nucleus [GO:0005634] ATP binding [GO:0005524]; SUMO conjugating enzyme activity [GO:0061656] AEAYTIYCQNRVEYEKRVRAQAKK 1 15.2 0.97442 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.21951 A0A8C0NDH9 A0A8C0NDH9_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP10B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FFCIFVITDIDTSYLE;IQGHSRQRSI;KLSVMTLSIGDGANDV;LARMVVYYFYK;NLDGETNLKQRRVVKGFSQ;TDKRDLEIQ;WQWRVRDALPQSPSEATPLLS 7 6.8 1.0038 -1.0591 0 0 9.66525 9.91748 9.89245 0 7.65985 11.0755 9.36411 0 0 3.06604 0 11.1524 0 A0A8C0NDI3 A0A8C0NDI3_CANLF Cyclin-A1 CCNA1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] nucleus [GO:0005634] AAFTGYSLNEIVPCL;CTGREGMAFEDVCGV;EIYPPEVDEFVYITDDTY;FTGYSLNEIVPC;GVDTSTLKSDLHF;INVTEYAEE 6 16.2 0.98679 -0.39824 0 7.08937 6.13672 0 0 0 0 6.62791 10.9058 0 0 0 0 0 0 A0A8C0NDI6 A0A8C0NDI6_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC22A17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GVGGHFLFLGLALVSKDWRF;LVGVGGHF 2 3.5 1.0044 -1.0538 0 8.58203 0 0 0 0 0 0 0 0 5.64077 0 0 0 0 A0A8C0NDL9 A0A8C0NDL9_CANLF PX domain-containing protein SNX7 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091] DEPESHVTTIETF;DMNSFSPMMPTSP;IQAELDSKVEALTYKKADTDL;LNRIADHPTLTFNE;PLPEKFIVKGM;QTVRAVAMSM 6 19.2 0.98781 -0.37202 0 8.57118 0 0 0 5.52165 0 0 5.12267 9.0839 0 0 0 0 0 A0A8C0NDM1 A0A8C0NDM1_CANLF "Cytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)" CYTH2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] cell projection [GO:0042995]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] AARKKRISVKKK;DREGWLLKLAGGRVKTW;THTFFNPDREGWLLK 3 8.5 0.98912 -0.21795 0 0 0 0 0 0 0 0 0 0 4.16928 0 0 0 0 A0A8C0NDM3 A0A8C0NDM3_CANLF TOG domain-containing protein PPP2R1B Canis lupus familiaris (Dog) (Canis familiaris) FCINALSEACGQEI;GEALNLFSSW;VRAAAAHK 3 5.2 1.0029 -1.6309 0 0 0 8.50092 0 0 0 0 0 0 0 0 9.7493 9.56546 0 A0A8C0NDM6 A0A8C0NDM6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;STKAKETKAKMNYWDFIKIRSFCTT 5 5.3 0.97483 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.64422 A0A8C0NDN6 A0A8C0NDN6_CANLF Adenine nucleotide translocase lysine methyltransferase ANTKMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] mitochondrial membrane [GO:0031966] protein-lysine N-methyltransferase activity [GO:0016279] LQGRGRGADGALALPPRGS;QGWGAGPT 2 7.4 0.98969 -0.21609 8.84226 0 0 0 0 0 0 0 0 0 0 10.1427 0 0 0 A0A8C0NDR5 A0A8C0NDR5_CANLF Linker for activation of T cells family member 2 LAT2 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; immune response-regulating signaling pathway [GO:0002764] AAGAGGCGCGCGCGCECGCGCGCGC;AGAGGCGCGCGCGCECG;AGAGGCGCGCGCGCECGCGCGC;AGAGGCGCGCGCGCECGCGCGCGC;AGGCGCGC;AGGCGCGCGC;AGGCGCGCGCGCECGCG;AGGCGCGCGCGCECGCGCGC;AGGCGCGCGCGCECGCGCGCG;AGGCGCGCGCGCECGCGCGCGC;AGGCGCGCGCGCECGCGCGCGCEC;AGSPDEDNE;AYIDPITTDYYNWGQFQKP;CECGCGCGCGCECG;CECGCGCGCGCECGVR;CGCECGCGCGC;CGCECGCGCGCGCECGVRV;CGCGCECGCGCGCG;CGCGCGCECGCGCGCGCECGVR;CGCGCGCGCEC;CGCGCGCGCECGCGCGCGCECGVRV;GAGGCGCG;GAGGCGCGCGCGCE;GCECGCGCGCGCECGV;GCECGCGCGCGCECGVR;GCGCECGCGCGCG;GCGCGCEC;GCGCGCECGCGCGCGCECGV;GCGCGCGCECGCGCGCGCECGV;GCGCGCGCECGCGCGCGCECGVR;GCGCGCGCGC;GCGCGCGCGCE;GCGCGCGCGCECGC;GCGCGCGCGCECGCGCGCGCE;GCGCGCGCGCECGCGCGCGCEC;GGCGCGCG;GGCGCGCGCGCECGCG;GGCGCGCGCGCECGCGC;GGCGCGCGCGCECGCGCGC;GGCGCGCGCGCECGCGCGCGCE;GVRVRVRVRVRVRVRVRVR;GVRVRVRVRVRVRVRVRVRV;GVRVRVRVRVRVRVRVRVRVRVR;PLAAGAGGCGCGCGCGCE 44 15.5 0.68519 0.29622 7.57425 9.90361 9.01931 6.87455 8.13175 6.76009 6.76885 8.18527 6.74214 6.20195 8.49637 9.78121 8.15056 9.9935 8.08969 A0A8C0NDR6 A0A8C0NDR6_CANLF Myosin-16 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; anatomical structure formation involved in morphogenesis [GO:0048646]; cellular component assembly [GO:0022607]; supramolecular fiber organization [GO:0097435] cytoplasm [GO:0005737]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] EKEGFIAGE;ESDLKMTIDNLNDME;HLTKTNSKLSTQIHE;ISEFRSADERA;LHQKTLDDLQ;NAYHDMLMNRENQSM;QENVIDAEE 7 4.5 1.0026 -1.1308 10.4506 8.56548 0 0 0 0 0 10.7712 11.4519 10.2014 8.74278 11.7316 0 0 0 A0A8C0NDR8 A0A8C0NDR8_CANLF WD repeat domain 49 Canis lupus familiaris (Dog) (Canis familiaris) FLAHGGAG;IVLWNNSTENAHCVLHPHYQRR;PAFLLDLER 3 5.5 1.0033 -1.6093 0 0 9.74414 12.5512 0 0 0 0 0 0 0 0 0 0 8.69801 A0A8C0NDS5 A0A8C0NDS5_CANLF Prolyl endopeptidase (EC 3.4.21.26) (Post-proline cleaving enzyme) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DPYAWLEDPDSEQT;IDNFEGEYDYVTN;LVAACANQR;LVPEHEKDVLEWVACVR;VGWGEARSLGAA;YSGQKKDTEIFYQFTS 6 8.8 1.0022 -1.3677 0 0 14.6358 0 0 0 0 14.7857 6.8198 0 0 11.869 0 0 10.7305 A0A8C0NDT1 A0A8C0NDT1_CANLF Exostosin like glycosyltransferase 1 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] AGSQHCAQIL;GVSHCSCCFARCFT;QFLWDAYFSSVE;QFLWDAYFSSVEKVI;SSTGLPDPHPRPGSSALSQ;WQSFPERMVGFLTWSHF 6 9.9 0.98687 -0.39688 0 0 0 10.6439 0 10.6114 10.9738 0 6.79675 0 0 0 7.24232 12.7088 0 A0A8C0NDU5 A0A8C0NDU5_CANLF DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein dimerization activity [GO:0046983] GTARPIGCPLP 1 2.2 0.98372 0.035491 0 0 10.3002 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NDV9 A0A8C0NDV9_CANLF "PWWP domain containing 3A, DNA repair factor" Canis lupus familiaris (Dog) (Canis familiaris) GGILPSPP;ILLRRLRKRRNLKSRLVHSRRQDA;KAKGILLRRLRKRRNLKSRLV;KRSLKDYRKAKGILLRRLRKRRNLK;RKAKGILLRRL;RRLRKRRNLKSRLVHSRRQD 6 6.8 0.86859 0.13667 0 0 0 0 0 0 0 0 4.97517 0 5.13282 0 0 6.34951 0 A0A8C0NE03 A0A8C0NE03_CANLF Astrotactin-1/2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) neuron migration [GO:0001764] membrane [GO:0016020] DDYDYEDDEDLPRRT;LSINPLAS;WLCDPETGECSCHEGYAPDPVH 3 5.6 0.9747 0.046925 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.23151 A0A8C0NE11 A0A8C0NE11_CANLF LPS responsive beige-like anchor protein Canis lupus familiaris (Dog) (Canis familiaris) AVRSLNVFYYLTYE;DNLMDVLQ;EASLPTELQEDSLSPAASE;EEDDDDYV;ELENIEPTQGLSIEASVTF;EMNFIIQEGESIICMVDLLEKC;EQMLACKGFLVI;GLPIRGIRMKFAVLTGLVEV;HYGTHYSTASFVLAWL;IGQCSNSL;IQEGESIICMVDLLEKC;KYRDILEPQNERRNQ;LDYRQYLSDEVDLTICSTL;LMVWQVSDLKH;LVEVGEVSN;LVNEGSRPREFWRLDYWEDDLRRR;NVLFEILIE;PAFDQRNGLRVIYKL;PGVENTPSAFSPLT;PLFAQLDYRQYL;TSEEFVRINRLALESE;VESSPTEE;VLFPLFAQLDYRQYLS 23 10.5 0.97328 0.041303 0 0 0 0 0 0 8.5534 0 0 0 0 0 0 0 0 A0A8C0NE41 A0A8C0NE41_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LDQINFYLDC;VGTEGEEDSFR 2 22.1 0.98759 -0.48144 0 0 0 0 0 0 0 0 0 0 0 10.2543 0 0 0 A0A8C0NE47 A0A8C0NE47_CANLF Integrin-linked protein kinase (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) ILK Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; sarcomere [GO:0030017] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GACQSPPA;LVTREVPFADLSNMEI 2 6.2 1.0027 -1.354 0 0 0 0 0 0 8.6037 0 0 0 8.22038 0 0 0 0 A0A8C0NE67 A0A8C0NE67_CANLF E3 ubiquitin-protein ligase UHRF (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF) (Ubiquitin-like PHD and RING finger domain-containing protein) (Ubiquitin-like-containing PHD and RING finger domains protein) UHRF2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] ADQTLTNMNRALAL;DEVDRGDEFTY;EITALKTISRTKK;FTYTGSGG;IGAESRNWRAGKPV;LPSTSKQTDVQ;PSCKTDSSEVVKAGEGL;PVRVIRSF;SSSPPKVKKTP;YHIEYDEYPESGTVEINVKDLRPRA 10 16.6 1.0034 -1.6883 0 6.26797 9.53458 8.6331 0 6.54179 0 10.4953 11.0717 0 0 10.7786 0 6.20967 6.26091 A0A8C0NE70 A0A8C0NE70_CANLF CREB regulated transcription coactivator 1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634] cAMP response element binding protein binding [GO:0008140] LHMLNDPDMVLADPA;LTHLGIGG;PPPQVPVGLPPGGP;QAAMMGLTGSHG;SPQHRPAG 5 9.5 1.0012 -0.94169 0 9.91797 0 0 0 0 9.33316 8.48289 0 0 8.9624 0 9.76243 0 4.1865 A0A8C0NE81 A0A8C0NE81_CANLF NLR family pyrin domain containing 14 NLRP14 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EEPDFVLCEDWTQVHP;GVCKEAFDEEAQKLLEAVR;IPWFEVKKAKREDLAN;KLQNLSLESCDL;PAELEFLELFLC;PPAEMWDDGSIIHCWQ;TEYENCYVFTHL 7 9.4 0.99898 -0.60955 5.55272 0 0 9.94645 0 9.9508 0 9.90947 0 0 0 0 6.7057 0 0 A0A8C0NE88 A0A8C0NE88_CANLF BAI1 associated protein 3 BAIAP3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of neurotransmitter secretion [GO:0001956]; regulation of dense core granule exocytosis [GO:1905413] late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome membrane [GO:0055038]; secretory vesicle [GO:0099503]; trans-Golgi network membrane [GO:0032588] SNARE binding [GO:0000149] EGQGLPLESLRDGSYK;SLEQNRFGRLSVRCHY 2 2.9 0.93565 0.098466 0 0 0 6.08835 0 0 0 0 7.43646 0 0 0 0 0 0 A0A8C0NE92 A0A8C0NE92_CANLF Parathyroid hormone 2 receptor Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EVKKLWSRW;ILVEGLYLHSLIF;ISIGKQEFFERLYVM;TTGASREPGQRAAG 4 6.6 1.0027 -0.84608 0 9.9393 9.0587 0 0 0 0 0 0 12.1875 0 0 0 0 13.3531 A0A8C0NEA3 A0A8C0NEA3_CANLF Protein artemis (DNA cross-link repair 1C protein) DCLRE1C Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] nucleus [GO:0005634] ATGENIVLE;EQGSQGWDSQSDTVLLSSQE;QERNSGDIT;TTDRNTQIHACRHP 4 8.7 1.0017 -0.91461 8.09286 0 0 9.34296 0 0 0 0 0 0 0 0 0 0 8.92908 A0A8C0NEB5 A0A8C0NEB5_CANLF Outer dense fiber of sperm tails 3B Canis lupus familiaris (Dog) (Canis familiaris) PAVHLPPL 1 1.9 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 3.3488 0 0 0 0 0 A0A8C0NEC6 A0A8C0NEC6_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] ELVDYILQKS;LDESFLELVDYILQKSHIAEDPDDL;LDSTHVELVVNYDFPL;SRRDHFSIERAQHEVPA;VRIPRRLVL 5 13 1.0023 -1.8684 9.2166 0 0 0 7.10507 0 0 0 7.95321 2.05613 0 0 0 10.5531 0 A0A8C0NEC9 A0A8C0NEC9_CANLF WW domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEESRRVFFYNPLT;DELEDEPEDEPEDA;EDEPEDALEDMQP;EGARRPWQDPHRRHRG;ELEDEPEDEPED;EPEDEPEDALE;RVFFYNPLTGEAVWEDE;TGEAVWEDEPEDELE;VGSRESLETDWGQY 9 22.2 0.99746 -0.10795 0 0 0 0 0 3.30393 0 10.4126 0 0 7.85636 0 0 0 7.37287 A0A8C0NED4 A0A8C0NED4_CANLF uridine/cytidine kinase (EC 2.7.1.48) UCK1 Canis lupus familiaris (Dog) (Canis familiaris) CTP salvage [GO:0044211]; UMP salvage [GO:0044206] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ribosylnicotinamide kinase activity [GO:0050262] GNPVCSQSTVCEKIME;PADVVLFEGILV;QSTVCEKIMEL;VCGCDHPSGG;VRDMFHLRLFVDTDSDVR 5 17.7 0.99825 -0.60412 0 10.294 0 0 0 0 0 0 0 0 0 0 8.47188 0 10.448 A0A8C0NED7 A0A8C0NED7_CANLF Solute carrier family 25 member 36 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] pyrimidine nucleotide transmembrane transporter activity [GO:0015218] APRPLPLKKKKKKKPL;APRPLPLKKKKKKKPLG;ELRPAPRPLPLKKKKKKK;ERGAPTCRPGPGPGGPAQPPRSP;FVGMMLAA;PAPRPLPLKKKKKKK;PLPLKKKKKKKPLGDHVK 7 10.3 1.0039 -0.81202 0 8.21111 0 5.2762 0 0 0 0 0 0 0 5.51264 0 8.87231 4.27344 A0A8C0NEF2 A0A8C0NEF2_CANLF hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) HMGCLL1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; oxo-acid-lyase activity [GO:0016833] LVWNQTDSVAYPC;PGSMKRML 2 5.6 1.0042 -1.0445 9.53263 0 0 0 0 0 0 0 0 0 0 8.50593 0 0 0 A0A8C0NEI3 A0A8C0NEI3_CANLF RESP18 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] EKFFPFPIKGYPH;GVGQFWSLPGFAT 2 10.2 0.98959 -0.20236 0 0 0 0 0 0 0 10.0971 10.3194 0 0 0 0 0 0 A0A8C0NEJ4 A0A8C0NEJ4_CANLF Wnt inhibitory factor 1 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] GAVPAAAL;KKRKKKRRE;KMAPFTHDFRKAQQ;SKCPQPCRNGGKCI 4 10.5 1.0041 -1.9843 0 0 0 0 0 0 5.91636 0 11.5207 0 6.93026 3.79857 0 0 0 A0A8C0NEK4 A0A8C0NEK4_CANLF DNA helicase (EC 3.6.4.12) CHD7 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] AEVTKAFEE;EADVWIPEPFHA;EGLKMMDLEHKV;ELDIDALNGRNNLV;EPVTHYLVKWCSLPYEDST;HCNNEADVWIP;HNADSPDFQLQAM;KEDALNLSVPRQRRRRRRKI;KYKNFSYLH;LEENPEFAVAP;LITAYQRSY;LSVPRQRRRRRRKI;QAMIQAAGKLVLIDKLL;RDETRDGFYMEDGDPS;RENATNGV;SEESSQLEGAVSRG;SVPRQRRRRRRKIE;VPRQRRRRRRKIEI 18 6.3 1.0044 -2.0183 10.8855 10.9845 8.81484 9.42373 10.0489 8.80855 8.66612 0 10.6598 11.4823 8.7362 10.971 10.6572 10.3872 0 A0A8C0NEK5 A0A8C0NEK5_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] lysophosphatidic acid receptor activity [GO:0070915] DVVVVALGLTVSVLVLLTNLLVIA;HSRLRGRVVMLIVG;MLIVGVWVAAL;VIAAIASNRRFH 4 15.2 0.98749 -0.34898 0 0 12.831 0 0 0 0 0 0 0 0 0 8.5423 0 6.03813 A0A8C0NEK8 A0A8C0NEK8_CANLF Leucine rich repeat containing 40 LRRC40 Canis lupus familiaris (Dog) (Canis familiaris) EGFEQLFNLED;GGTGAPGSLA;LEDLDISN;LENLQKLNV;LENLQKLNVSH;QEVLKYLRSKIK 6 5.7 0.9902 -0.26579 0 0 0 0 0 0 0 9.26146 0 0 0 0 0 0 0 A0A8C0NEN9 A0A8C0NEN9_CANLF MHC class I-like antigen recognition-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PGHGPPLG;VLPCETQQ 2 4.4 1.0017 -1.2078 0 0 0 0 0 0 0 0 16.704 0 0 9.27373 0 0 0 A0A8C0NEP5 A0A8C0NEP5_CANLF FHA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CHIQNVAVKLL;DVNQLKSENKEKD;KERLEDHEQRNSKE;LSSQEEQSFSDLGA;TTVGRHEDSDL 5 4.4 0.7479 0.24053 0 0 0 0 7.04024 7.2034 0 0 0 10.262 6.54018 8.03397 10.8957 0 0 A0A8C0NEP7 A0A8C0NEP7_CANLF Agenet-like domain-containing protein FXR1 Canis lupus familiaris (Dog) (Canis familiaris) "muscle organ development [GO:0007517]; negative regulation of translation [GO:0017148]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]" cytoplasmic ribonucleoprotein granule [GO:0036464]; dendritic filopodium [GO:1902737]; dendritic spine neck [GO:0044326]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynapse [GO:0098793] mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; translation regulator activity [GO:0045182] KKEMAKDVIEEHGPSE;SERKDELSDWSL;SNPYSLLDN;VIQEIVDKSGVVR 4 8.7 1.0012 -0.70454 0 0 0 0 8.87599 0 0 0 0 10.8528 0 0 9.2105 0 0 A0A8C0NER9 A0A8C0NER9_CANLF mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K6 Canis lupus familiaris (Dog) (Canis familiaris) MAPK cascade [GO:0000165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] APDLYCMCGRVYKD;EGPPHRAHFWL;FDVEPSLHSGINAAVLL;LGPEVETEAIPP;LQYMAPEIIDQGPRGYGKA;PGRPGRCCFLYALPPAQDVQL;RERFSGQQLRQELARLQRRLDSVE 7 9.2 0.97747 0.047716 0 0 0 0 5.42206 0 0 0 0 0 0 0 0 0 0 A0A8C0NET4 A0A8C0NET4_CANLF Glycosyltransferase 6 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758] FACCVFYFGTCLICF;GDFYYHSAIFGGTPGE 2 10.4 0.98236 -0.24976 0 0 0 0 0 0 0 0 0 0 0 0 10.7023 0 0 A0A8C0NEV8 A0A8C0NEV8_CANLF Beta/gamma crystallin 'Greek key' domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] EQVELTDALEDTQGLEK;EVLVTGPG;FEDDQTSLP;FGEKNFEGDQ;PRQTWSISESGHIC;QPPYTAPEVP;QVIGPPSP 7 4.1 0.99855 -3.0062 0 0 0 0 10.2066 0 0 0 12.2107 0 0 0 9.88991 0 0 A0A8C0NEX0 A0A8C0NEX0_CANLF ATP synthase subunit alpha ATP5F1A Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]" "ADP binding [GO:0043531]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" AVAYRQMS;VGEELLGRV 2 3.4 1.0016 -1.3145 0 0 0 5.37914 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NEY3 A0A8C0NEY3_CANLF Keratin 222 KRT222 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] QERGLENSLHA 1 4.4 0.9852 0.035491 0 9.44692 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NEY9 A0A8C0NEY9_CANLF FERM domain-containing protein FRMD5 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EGKTFYLYVSQKEE;FYPADPAA;LNDARKKLILRMKSFR;SSNLFFKGSRFRY 4 11.9 0.95687 0.049233 0 0 0 0 6.24239 0 0 0 0 0 0 0 0 0 0 A0A8C0NF03 A0A8C0NF03_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] TSRDEDMASPVF;TVCMFRTEKIR;VGSHHAFFSDDQE;YRLHIPPALTENDR 4 4.5 0.98421 -0.25442 0 0 0 8.13643 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NF05 A0A8C0NF05_CANLF Kinesin-like protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AAETGDHALLQ;DDYGRNPL;DEEISSLYRQLDD;DNTPIIDN;RLQDAEEMKKAL;SNHQKKRATEI;TIVICCSPSVFNEAE 7 8 1.0031 -2.357 8.18453 0 0 0 0 8.7652 0 9.85167 0 0 0 8.16707 0 0 7.98624 A0A8C0NF19 A0A8C0NF19_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) ARIH1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AEEEEDEDDDEP;AEEEEDEDDDEPDDD;DAQERSRAALQRYLFYCNRY;DEECSEEDSG;DKEKLMERRLITDSKVKL;EDEDDDEPDD;EDEDDDEPDDDN;EDEDDDEPDDDNLDLG;EDEECSEE;EDSGAEEEEDEDDDEPD;EEEEDEDDDEPDD;EFDEDEECSEEDSGAE;EFDEDEECSEEDSGAEEEEDED;EGYNYEFDEDEECS;GAEEEEDEDDD;GAEEEEDEDDDEPD;GGGGGGGG;GGGGGGPG;GVGGERDGLLCGETGG;PGGGGGGG;SDEGYNYEFDEDEECSEEDSGA;YNYEFDEDEECSEEDSGAEEEE 22 24.1 1.003 -1.9519 10.6595 0 6.13879 0 6.51278 7.15421 6.42356 5.35998 4.76123 2.82873 4.414 6.78254 6.69947 7.41752 6.84637 A0A8C0NF25 A0A8C0NF25_CANLF B box-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CKTASEAKCSQNESDEDS;CLECGEDYCSGCFAK;DDTYEEEYEEPGDI;FSLLRLVKIFIS;LVCLECGEDYCSGC;PEPSLKIVELDDTY;SAGKVKLKLLKEQLQEPVK;VIKLSAGKVKLKLLK 8 11.8 0.9912 -0.29443 4.86938 7.774 0 0 0 0 0 0 0 0 0 0 6.92125 0 9.16787 A0A8C0NF37 A0A8C0NF37_CANLF Olfactory receptor LOC482237 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LILASGCWFLGSVDSFLF;LILLIHSDSHLHTPMYF;MYFFISQLSLMDMM 3 14.4 0.87053 0.1619 0 0 0 8.52802 0 0 0 0 8.56917 0 0 0 9.90433 0 0 A0A8C0NF39 A0A8C0NF39_CANLF Mitochondrial Rho GTPase 2 (Ras homolog gene family member T2) WDR90 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005]; mitochondrion transport along microtubule [GO:0047497]; small GTPase-mediated signal transduction [GO:0007264] mitochondrial outer membrane [GO:0005741] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] CEQDSQAHAITVTR;LHVPPGCS;PEKVPTHIVDYSE;RWVCGHCRPQHLALQ 4 6.2 0.99027 -0.26654 9.39187 0 10.5067 9.41043 10.1388 0 10.7912 10.6399 9.99774 0 0 0 0 0 0 A0A8C0NF65 A0A8C0NF65_CANLF ferroxidase (EC 1.16.3.1) Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491]; signaling receptor activity [GO:0038023] IMFTLVDENQSW;LIHCHVSDHIHAGMETTYTVLRNID;PTGLATLFLERGP;TDVDREFIIMFTLVDENQ;VGPLLVCK;VVENPGKWMITCQ 6 7 1.0021 -1.2217 0 0 0 0 4.26581 0 11.1013 8.07178 8.98539 0 10.7051 0 0 0 10.2392 A0A8C0NF66 A0A8C0NF66_CANLF Anoctamin ANO4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] IIEIRLDAYKFV;PGAYLRLINR 2 2.3 0.99008 -0.26699 0 9.4349 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NF68 A0A8C0NF68_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DLCQKQACEIQK;NYMESKCQAVMQ;SSVFLTLSSGQVAAN 3 48.1 0.98645 -0.42406 0 10.2386 0 0 0 0 10.7387 0 0 0 0 0 0 0 0 A0A8C0NF81 A0A8C0NF81_CANLF glutathione transferase (EC 2.5.1.18) Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] cytoplasm [GO:0005737] glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802] DILENEVMDTRIYF;PTSLDVFPNLK 2 12.1 0.98427 -0.23955 0 0 0 0 0 0 0 0 0 0 7.03056 0 0 0 0 A0A8C0NF94 A0A8C0NF94_CANLF Potassium inwardly rectifying channel subfamily J member 4 KCNJ4 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] inward rectifier potassium channel activity [GO:0005242] DTRWRYMLMIFS 1 2.7 0.98313 -0.25582 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9477 A0A8C0NFA1 A0A8C0NFA1_CANLF U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) SNRPC Canis lupus familiaris (Dog) (Canis familiaris) mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; U1 snRNA binding [GO:0030619]; zinc ion binding [GO:0008270] HCSGRKHKENVKDYYQKWIEE;IEEQAQSLINKT 2 17.3 0.9876 -0.48207 0 0 0 0 0 9.94533 0 0 0 0 0 0 0 0 9.60463 A0A8C0NFA4 A0A8C0NFA4_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] KNLHLFGV;VFFYFFVCFFLFF;VLMTRVNEVEERVSDKD 3 14.2 1.0017 -0.99559 0 0 0 0 7.59932 0 0 0 7.44667 0 0 0 0 0 8.08603 A0A8C0NFA6 A0A8C0NFA6_CANLF Inositol oxygenase (EC 1.13.99.1) (Myo-inositol oxygenase) MIOX Canis lupus familiaris (Dog) (Canis familiaris) inositol catabolic process [GO:0019310] cytoplasm [GO:0005737] inositol oxygenase activity [GO:0050113]; iron ion binding [GO:0005506] TGGDYRQL 1 2.8 1.0031 -1.1044 0 0 0 5.46849 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NFB5 A0A8C0NFB5_CANLF GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] "alpha-1,4-mannosyltransferase activity [GO:0051751]; glycolipid mannosyltransferase activity [GO:0004376]" GGGGGGQK;LGFYRRYGWEFLEHTY;QDRALLVRY;YTDVDYRVF 4 8.7 1.0025 -0.79162 0 0 8.697 0 0 0 0 0 0 0 0 5.061 0 10.8285 0 A0A8C0NFD7 A0A8C0NFD7_CANLF Tight junction protein 2 TJP2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] EEVGEGSEEQEGA;LVSSITRSSEPVQHEES;SEGKMEGMDDDP;VLQRMWIQ 4 4.3 1.0032 -1.9263 0 0 0 0 0 7.89445 0 0 0 0 0 0 0 14.5735 0 A0A8C0NFD8 A0A8C0NFD8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FTDDSCKGPQSAGE;KKPILAKLNFHLRKKILEIQ;LYTLKKPILAKLNFHLRKKIL 3 6.7 0.93512 0.060864 0 0 0 0 0 0 0 0 0 0 0 9.06614 0 0 0 A0A8C0NFE8 A0A8C0NFE8_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AQMLQTPNK;LAVNHYELQLRF;LVMVTPVNEFSPACVPHTFRIRED;PSSQISFLQQAPN 4 7.4 1.0022 -0.6527 0 0 0 0 0 0 0 8.62505 8.472 0 0 0 0 6.38593 9.72988 A0A8C0NFF0 A0A8C0NFF0_CANLF Anion exchange protein SLC4A3 Canis lupus familiaris (Dog) (Canis familiaris) bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453] plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;DYHELGRSI;EDRASVLRTLLLK;EPHWRETARWIKFEEDVEEETERWG;GEAEGRGPWMAPAPSTRDS;GPLLVFEEAFFKFCRSQD;HPLLPFYPPEGALEAGLE;KPLHMPGGD;VLRRKKKKK;VLRRKKKKKQL;VLRRKKKKKQLDRR;VLRRKKKKKQLDRRP 12 13.7 0.98328 -0.25384 0 0 0 9.37899 0 0 0 0 0 0 9.62298 0 0 0 0 A0A8C0NFF6 A0A8C0NFF6_CANLF Premelanosome protein PMEL Canis lupus familiaris (Dog) (Canis familiaris) KSWDAEGQQEEAIWRGA;PSGATAVQMTTT;PTAEVISTTPGQVP;TAEIPGTTAGRVPTAE;TGKAVLGTHTMEVTVYHRRESQSYV 5 13.2 0.72956 0.26081 0 0 0 0 8.94067 0 0 10.3501 0 0 0 0 10.5699 0 7.51365 A0A8C0NFI5 A0A8C0NFI5_CANLF "Zinc transporter SLC39A7 (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7)" SLC39A7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular zinc ion homeostasis [GO:0006882] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]; zinc ion transmembrane transporter activity [GO:0005385]" AFLVVEKFVRHVKGGHGHSHGH;DTSQAPQWKSLEVFTCNCLTDPGL;HSNRPPADEDSEF;VPHEVGDFAILV 4 11.7 0.99188 -0.27204 0 0 0 0 9.02034 0 0 0 0 0 0 0 0 0 0 A0A8C0NFJ0 A0A8C0NFJ0_CANLF Glucagon receptor Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] glucagon receptor activity [GO:0004967] HRVERPCRLGDSAAEAGGVG;IFIRVLLILMVK;LDPDMGSL;PWETQPAGRQDP;VRRGVRVPTRTLCPSCVA 5 7 1.0009 -0.62127 0 0 0 0 0 0 0 0 10.3059 10.2358 0 4.01837 0 0 0 A0A8C0NFJ6 A0A8C0NFJ6_CANLF Fusion protein IQCJ-SCHIP1 N-terminal domain-containing protein LOC478678 Canis lupus familiaris (Dog) (Canis familiaris) WREYLQRQDPLEKRSP 1 14.4 0.98236 -0.25112 0 0 9.29313 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NFK5 A0A8C0NFK5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ESIPFTIAPQN 1 1.4 0.9849 0.035491 0 9.64947 0 0 0 0 0 0 0 0 0 2.44483 2.57935 0 0 A0A8C0NFM2 A0A8C0NFM2_CANLF DOCKER domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EDAGMMDVH;EKDPEMLIDLQYSLAKSY;ELKKLCSS;FANSDRPMKAT;IQDSDKVNAKELDPKYAHI;KEDAGMMDVH;SLLSIHTE 7 11.5 1.0036 -1.1044 0 0 0 0 0 0 0 7.34359 0 0 0 0 0 0 0 A0A8C0NFM7 A0A8C0NFM7_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] intermediate filament [GO:0005882] structural molecule activity [GO:0005198] GEGCGSGFGGSDFRNSGS;ITELKRTL;SRDMSMSGESRS;SSLEATLADTEAGYM;VGGGLGGTS 5 11.9 1.0029 -2.1179 0 0 0 0 0 0 0 0 10.3457 0 0 19.8753 20.1562 7.98277 11.4676 A0A8C0NFN2 A0A8C0NFN2_CANLF Histidine rich calcium binding protein HRC Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; ossification [GO:0001503] calcium ion binding [GO:0005509] EDDDDDDAMS;EEDDDDDDAMSTEYGH;EEDQGSHEEDDE;EEEEEEEDQGSHEEDDESSEW;EEGHGLSLSQEEEEEEEEE;EEQEEEEDDDDDDA;EHGHHFPNHRSH;EQEEEEDDDDDDAMS;EQEEEEDDDDDDAMSTEY;HLRERDSEEEEEEEDQGSHEEDDE;HQAHSHGGHRKEEDED;KDEDEVVSTE;LSRKLRRLFLLL 13 15.9 0.95459 0.05044 0 0 0 0 0 0 5.27012 0 0 0 0 0 5.15805 0 0 A0A8C0NFP7 A0A8C0NFP7_CANLF Serine/threonine-protein kinase 4 (EC 2.7.11.1) STK4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262]; signal transduction [GO:0007165] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EDEMDSGTMV;NSEEDEMDS;VIGTPFWMAPEV;VYKAIHKET 4 7.9 1.0032 -2.0707 9.73283 0 0 0 0 0 0 0 3.17199 0 0 0 0 0 0 A0A8C0NFQ4 A0A8C0NFQ4_CANLF Voltage-dependent anion-selective channel protein 3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] NTLGTEISLENKLNW 1 12.6 0.95006 0.053907 0 0 0 0 0 0 11.1801 0 0 0 0 0 0 0 0 A0A8C0NFR6 A0A8C0NFR6_CANLF Olfactory receptor LOC119864895 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GFNLVIVPKMLDTLIIQ;SLFYSTAILTYFRPRSSTSPE;VLVSFSTLSSEIQA 3 16.5 0.9894 -0.19714 3.42129 0 7.14129 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NFT2 A0A8C0NFT2_CANLF Galectin LGALS7B Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] EAPGSEAALHFNPR;GGGGGGGG;QPAGRGGG 3 8.1 1.0027 -1.4031 0 0 0 0 8.13288 0 0 0 0 0 0 0 0 0 0 A0A8C0NFT4 A0A8C0NFT4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) NNSLFNKLCWEN 1 1.6 0.99696 -0.111 0 0 0 12.5635 0 0 0 0 0 0 14.1129 0 0 0 0 A0A8C0NFT5 A0A8C0NFT5_CANLF Zinc finger protein 182 ZNF182 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" HKCTECGKSFNE;QERIKNGEKPFECTACRKTFS;QIERQHQVDQ 3 6.9 1.0026 -0.80012 0 0 0 0 0 9.91516 0 0 5.88228 0 0 9.67515 0 0 0 A0A8C0NFT7 A0A8C0NFT7_CANLF Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) LRRC8E Canis lupus familiaris (Dog) (Canis familiaris) aspartate transmembrane transport [GO:0015810]; cell volume homeostasis [GO:0006884]; cellular response to osmotic stress [GO:0071470]; cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361] endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] volume-sensitive anion channel activity [GO:0005225] EASVGPGK;FAVFLSEVSES 2 2.4 1.0039 -1.0689 0 0 10.4846 0 0 9.58729 0 0 7.32625 0 0 0 0 0 0 A0A8C0NFU1 A0A8C0NFU1_CANLF Membrane bound O-acyltransferase domain containing 1 MBOAT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] LMIVTQKI;LYNLTGYEL;MTLVSLLLFLTLTKTFPVT;QTATWLKRVCYE;TIFGIYFVIFCFGW 5 12.2 1.0041 -0.80421 0 0 11.5861 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NFU6 A0A8C0NFU6_CANLF Immunoglobulin superfamily DCC subclass member 3 Canis lupus familiaris (Dog) (Canis familiaris) LIQDPGIMVP 1 1.6 0.9831 -0.25668 0 0 0 0 0 0 0 0 0 8.50518 0 0 0 0 0 A0A8C0NG04 A0A8C0NG04_CANLF hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29) Canis lupus familiaris (Dog) (Canis familiaris) "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" DGQLVSQKSDSSKDIRGD;PGPAPAASAARRR 2 8.3 0.9253 0.10805 0 0 0 0 7.5624 0 0 0 0 0 0 0 0 0 8.25035 A0A8C0NG20 A0A8C0NG20_CANLF Lipase maturation factor LMF2 Canis lupus familiaris (Dog) (Canis familiaris) protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789] GGGGGGGG;GGGGGGGGK;LLLRPLRNLFVYLLLWA;WLKMVILPTM 4 5.4 0.98767 -0.22954 0 0 0 0 0 0 8.70591 0 0 0 12.3065 0 0 0 0 A0A8C0NG26 A0A8C0NG26_CANLF Myosin X Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DESSEEDPYMNDTV;EDLQRMKERQE;FRTGSCRPAEGRG;HYDYDRDDYEDGA;LVWEDIDW;RAFLLRRRFLHLRKAAI;RERERARREAELRTQQEE;TFTPCERLEKRRTSFLEGTL;TYKQSTITQQ;VEFAFMFEQAHEAVIR 10 7.5 1.0034 -1.6545 8.37808 12.5002 0 0 8.06086 0 0 8.69537 10.6156 0 0 8.05463 7.62717 0 5.69605 A0A8C0NG78 A0A8C0NG78_CANLF Calsequestrin Canis lupus familiaris (Dog) (Canis familiaris) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809] sarcoplasmic reticulum lumen [GO:0033018]; Z disc [GO:0030018] calcium ion binding [GO:0005509] CLPPRSWRTGWRTCWRARST;EFSADTLV;PLALLLLLVLGPPRLGVQGEE 3 9.8 0.98182 -0.24879 0 0 0 0 0 0 0 0 9.54634 0 0 0 0 0 0 A0A8C0NGB0 A0A8C0NGB0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VILLVVHT 1 4.3 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 4.92005 0 0 0 A0A8C0NGB3 A0A8C0NGB3_CANLF Transporter Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] AKVLLIILITITILPIPAYF;GSLIFVRPS;VGICVSLFLGSL 3 5.5 0.98954 -0.51965 0 12.4667 0 0 0 0 0 0 5.6293 0 0 0 0 0 0 A0A8C0NGC0 A0A8C0NGC0_CANLF Laminin subunit beta 2 LAMB2 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; tissue development [GO:0009888] CARGFSGVF;EAWEMHGAGLVGIRV;EQLLQGPLGDQYQTV;ERRATFERY;FERYRCHEEGLVPSKTLPSE;GGDAAALE;PCECNGNIDPMDP;QPGYFRPFLDHLTW;STEGEVIYRVLD;TGGEHCERCIA;VCNGHADECDTHTGACLGCRDH;YKLLLKLVR 12 8 1.0022 -1.8755 9.87015 11.0809 0 9.07516 0 10.1144 10.0109 6.36487 4.25482 0 5.81255 0 11.4107 13.3069 8.7173 A0A8C0NGC6 A0A8C0NGC6_CANLF GDP-mannose pyrophosphorylase A GMPPA Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] FKDGKLLPAITILGTTSQGT;VHLTDGIWSQIKSAGS 2 7.8 0.98835 0.032244 0 12.0703 0 0 9.59421 0 12.2703 10.6992 0 0 0 0 0 0 0 A0A8C0NGD3 A0A8C0NGD3_CANLF ANKH inorganic pyrophosphate transport regulator ANKH Canis lupus familiaris (Dog) (Canis familiaris) phosphate ion transmembrane transport [GO:0035435] membrane [GO:0016020] phosphate transmembrane transporter activity [GO:0005315] DLHTCPRGD;GLVFVNSKR 2 3.5 1.0045 -1.0516 0 0 0 0 0 0 7.33244 0 0 7.79468 0 0 0 0 0 A0A8C0NGE1 A0A8C0NGE1_CANLF TEA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) embryonic organ development [GO:0048568]; hippo signaling [GO:0035329] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVREEGEREKF;GGAAGGGGQ;PVQLHRQHDHQRLHQGVLV 3 4.7 1.0028 -0.71916 0 9.29503 0 8.2738 0 7.09117 0 0 0 0 0 0 0 0 0 A0A8C0NGE2 A0A8C0NGE2_CANLF DEK-C domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of double-strand break repair [GO:2000779] nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393] EEEDEDDDDEEEEEEEEKE;EPLIKKLKKP;LIKKLKKP;PLIKKLKKPPTDEELKE 4 10.5 0.95391 0.04941 0 6.49784 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NGF3 A0A8C0NGF3_CANLF Integrin subunit alpha V Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] AAVEIRGVSSPDHIF;LPLPLPLPLLLLLPLGLLPRP;TDYHCDYCCN 3 5.2 1.0027 -0.79479 0 0 0 3.3846 0 0 0 7.08012 10.1818 0 0 0 0 0 0 A0A8C0NGH5 A0A8C0NGH5_CANLF Insulin-like growth factor-binding protein 4 RAPGEFL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of insulin-like growth factor receptor signaling pathway [GO:0043567]; small GTPase-mediated signal transduction [GO:0007264] extracellular space [GO:0005615] guanyl-nucleotide exchange factor activity [GO:0005085]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995] CMELSEIEAI;QESLQPSDKDEGDHP;VHELEFVDYVFH 3 4.9 0.99119 -0.54697 0 9.85287 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NGI6 A0A8C0NGI6_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GGGGGRPG;PADLPSEDS;QPRAVRRRRRRRRLPRRRRPR;RGRGSAPPRGHLP 4 6.2 1.002 -0.68346 0 0 0 0 0 0 6.81019 0 0 7.41041 0 0 0 0 6.98937 A0A8C0NGJ2 A0A8C0NGJ2_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AVEAMKRQY;LAVEAMKRQ;SLPRPAEEELPSA 3 6.2 0.99669 -0.58339 9.97799 0 0 0 0 0 0 0 0 0 0 0 10.3455 0 0 A0A8C0NGJ7 A0A8C0NGJ7_CANLF Interleukin-12 subunit alpha (IL-12A) IL12A Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-12 receptor binding [GO:0005143] CLPLELTMNESCL;EACLPLELTMNESCLA;FYKTKIKL;IFLDQNMLTAIDELLQ 4 18.1 1.0039 -1.0726 0 0 0 0 0 0 0 0 0 0 5.47748 5.85095 0 7.61331 3.96181 A0A8C0NGL6 A0A8C0NGL6_CANLF Coiled-coil domain containing 14 CCDC14 Canis lupus familiaris (Dog) (Canis familiaris) CTKEQIAEVTSEGKDL;ETTRIKIELEEALVNLKSS;ETVQGLDGC;NGILPQQEVP 4 6.5 1.0035 -1.1096 0 9.65015 0 0 0 0 0 10.4878 0 0 0 0 7.57856 0 0 A0A8C0NGN8 A0A8C0NGN8_CANLF Bromodomain adjacent to zinc finger domain 2A BAZ2A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CKADKMLAMQRRLEE;EEMKKPTEDMCLTDHQ;EGRLRRTGRPEVELQGPEESLGR;EILRCFLMAYGV;LEERQRQQMILEEM;LEKALLST;LTPDSSPG;QSSTIQLHPATSPAVPP;RGRRDGEVDA;VLPAASPADKDVSTFPETTTDLEEI;YGVEPALCD 11 8 0.99703 -3.5852 0 6.59477 11.9911 0 4.95331 5.8539 0 0 12.4669 0 0 9.08127 9.80547 6.47824 0 A0A8C0NGQ3 A0A8C0NGQ3_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEDVRRLFQPFGHIE;GGGGGGGA;GGGGGGGG;GGRGGGGG;PASRRRRRRRRRRRRRPAPPP 5 8.7 0.99103 -0.19595 9.72101 0 0 0 0 0 6.83251 0 0 0 0 0 0 0 0 A0A8C0NGS9 A0A8C0NGS9_CANLF WAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ASKGELESLRWYPGKAKHGACPFT 1 17.4 0.94898 0.056242 0 0 0 0 0 0 0 7.2764 0 0 0 0 0 0 0 A0A8C0NGU1 A0A8C0NGU1_CANLF Sec1 family domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] ALWEALLS;EQVLAKVKRAL;NPAGPLTWMRWDR;SHAAHLTANHVPAAAAAELEGQ;WEALLSTKHKE 5 7.7 0.99183 -0.27051 0 8.84881 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NGV4 A0A8C0NGV4_CANLF FKBP prolyl isomerase 8 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066] cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740] protein folding chaperone [GO:0044183] DFEVLDGVED;EPEPEPAPAPDEWLDILVDMTF;GVEDAEGEEEEEEEEEEE 3 18.3 0.99434 -0.17373 0 0 0 8.66107 0 0 4.96721 0 0 0 0 0 7.38948 0 0 A0A8C0NGW0 A0A8C0NGW0_CANLF U3 small nucleolar RNA-associated protein 25 homolog (UTP25 small subunit processor component) Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] U3 snoRNA binding [GO:0034511] GVAILQRSIRLYAP;LATLKNASEE;LNFTHICEYTPK 3 5.1 0.98689 -0.4999 0 9.92059 6.74846 0 5.8629 0 0 0 0 0 0 0 0 7.24736 0 A0A8C0NGY3 A0A8C0NGY3_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) ACVR2A Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363] activin receptor complex [GO:0048179] activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] CAAACAAVP;GAGPRLQPARTRSAGRLRGRGV;QEVVVHKKKRPVLR;VLRDYWQKHAGMAML 4 7 0.97547 0.046904 0 0 0 0 0 9.16179 0 0 0 0 0 0 0 0 0 A0A8C0NGY7 A0A8C0NGY7_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSL3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] membrane [GO:0016020] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] DFFEDENGQRWLCTG;ICFCCPVGQGYGL;KDIVSLVPRLRHIITV;KLKQTINPILLYFIHFLISLYTV;NICAYANS;NTDKPHPRGE;VILGNYNWLSYEDVF;VIMYTSGSTGLPKG;YTVFTYIPYYFLFET 9 18.4 1.003 -1.5244 8.32679 10.3595 0 6.27434 0 0 8.03903 0 0 0 0 0 10.3528 7.38991 8.25729 A0A8C0NGZ3 A0A8C0NGZ3_CANLF "Major histocompatibility complex, class II, DQ beta 1" DLA-DQB1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] FLFFEVSTSEPPG;LIFLGLGLIIRHRSQKG;VGEYRAVT 3 12.5 0.7205 0.25949 0 0 0 5.1686 0 0 0 0 0 10.3 0 0 7.09117 0 11.2155 A0A8C0NH09 A0A8C0NH09_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] EGANVISLSVG;STVYIDGKPEIQ;VGFSGFAISGFNVNHLDIAPRY;WRGQRGVTLDEEELTSHQNEE 4 12.3 0.87623 0.1336 0 0 0 0 0 0 8.56247 0 0 0 0 0 0 0 9.44114 A0A8C0NH27 A0A8C0NH27_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYYLVSLSDF;NSFRSVFPAYYL 2 19.6 1.0014 -0.91506 0 0 0 0 0 0 0 0 0 0 0 0 8.88771 0 0 A0A8C0NH31 A0A8C0NH31_CANLF VOC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GHYKLGNDFMGITLVSSQAVCN;KLELQGIKGTIDH 2 12.6 0.98958 -0.53079 10.9219 0 0 0 0 0 0 0 0 0 0 0 0 12.0227 0 A0A8C0NH35 A0A8C0NH35_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2B4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] AEMELRRGQILWFRGLNRIQTQVL;AYSVKKMMK;DPVRPEVP;FASLALATEPPTESLLKRRP;GVALEIQPLNSQEGI;LPANSTVESREGDFG;PWLSECTPIYIQ;VGEQRQVVAVTGDGT 8 10.7 1.0006 -2.7713 0 8.04952 9.51816 8.23974 0 6.62379 11.4577 0 0 0 0 0 9.85337 11.5101 0 A0A8C0NH45 A0A8C0NH45_CANLF PAS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of membrane potential [GO:0042391] delayed rectifier potassium channel activity [GO:0005251] KNRKGDVFGDVFWKEATLAQSCANV;KRIVFRKISDVKREEEERMKRKNEA 2 11 0.97902 0.035538 0 0 0 0 0 0 0 0 0 6.87418 0 0 0 0 0 A0A8C0NH59 A0A8C0NH59_CANLF Odontogenic ameloblast-associated protein (Apin) ODAM Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; nucleus [GO:0005634] PLPFQGPFNSWIP;TVVMPAGV 2 7.7 1.0043 -1.0445 0 0 0 0 0 0 0 0 0 0 8.352 4.04658 0 0 0 A0A8C0NH63 A0A8C0NH63_CANLF X-prolyl aminopeptidase 2 XPNPEP2 Canis lupus familiaris (Dog) (Canis familiaris) VGFDPFLFSIGMLFP 1 8.2 0.93378 0.067784 0 0 0 0 0 0 0 0 10.002 0 0 0 0 0 0 A0A8C0NH71 A0A8C0NH71_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" SLC25A4 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743] ATP:ADP antiporter activity [GO:0005471] GVDRHKQFWRYFAGN;VHIIVSWMIAQ 2 9.6 0.99471 -0.12578 0 0 7.04067 0 0 0 11.307 0 0 0 0 0 0 0 6.84386 A0A8C0NH83 A0A8C0NH83_CANLF Schwannomin interacting protein 1 C-terminal domain-containing protein LOC478678 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGGGGGGGK;SDYREDGMDLGSDA;VIDEWAPEE;VIDEWAPEED 5 7.3 1.0024 -0.75719 0 0 0 0 0 0 11.5 11.2875 11.6456 0 0 11.685 0 0 0 A0A8C0NH87 A0A8C0NH87_CANLF Solute carrier family 25 member 34 SLC25A34 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] GSAAQLATFA;LYNQPVDGTGRGQLYS;VLGASACCLACVFTN 3 12.9 1.002 -0.66968 0 0 11.3035 0 0 0 0 0 0 0 0 0 12.5585 0 0 A0A8C0NHA0 A0A8C0NHA0_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] dendrite [GO:0030425]; membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005] PEAAYTTRV 1 5.8 1.0044 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 7.46385 0 A0A8C0NHA4 A0A8C0NHA4_CANLF Right handed beta helix domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; spindle [GO:0005819] DEDSCSDCSNHD;HVRFFYQNIWRSWDEEEEDEYDYFV;HYMVHGTFAIAD;KKKKKKKGKK;KKKKKKKK;SWDEEEEDE;VKKKKKKKKGK;VKKKKKKKKGKK;VKKKKKKKKGKKHPK;VKKKKKKKKGKKHPKN;YHNLLSQCEESYRK 11 10.3 1.0027 -1.7441 0 0 8.04903 6.01995 5.93631 0 0 0 5.3585 0 3.73433 0 5.82451 3.0418 0 A0A8C0NHA8 A0A8C0NHA8_CANLF G protein-coupled receptor 158 GPR158 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] G protein-coupled receptor activity [GO:0004930] CPYCADDSPC;VTLKLHRVLKVFLSRTAQRI 2 2.6 0.99138 -0.27643 0 0 0 0 0 0 0 0 0 0 0 0 7.75682 0 0 A0A8C0NHB2 A0A8C0NHB2_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) UBR2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AVLDNSPMVSNMAL;CTEENGMDQENPAGEEELAVL;EAYKKCLAVLMQC;GGGFCDCGDT;LFQENNEI;MHPDLSCGTHTGSCGHIMHAHCWQ;QIFSTPDYGKR;VLSKNRSKFIQDPEKYDPL;WHQHSITEEI;YLSLPNNL 10 8.4 1.003 -1.122 12.1416 5.50395 0 10.8203 0 0 6.33271 0 7.00888 0 10.1857 0 10.0264 8.17742 10.1257 A0A8C0NHB3 A0A8C0NHB3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;WKNVPCSW 5 6.1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 9.57094 10.0534 0 0 A0A8C0NHB5 A0A8C0NHB5_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] ALSPMLGATISI;DLRFASNHTQWFEVN;GDIRNVKTVCEGD;HQVYEVKLPRQV;LLLLLLLL;LLLLLLLLP;LLLLLLLP;RDPRIPLGASPP;RLLLLLLL;RLLLLLLLL;TLPLLLLT;TVINSVSRHDQ;VAFSSACG 13 14.1 1.0023 -2.5839 0 12.3635 0 0 0 0 0 0 0 0 8.9633 0 8.42219 7.93987 0 A0A8C0NHB7 A0A8C0NHB7_CANLF Neuropeptide W Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] G protein-coupled receptor binding [GO:0001664] AGRRALGPGLLLLLLLLAL;LLLLLLLALPA;LLLLLLLL 3 13.5 0.99647 -0.58401 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.67983 A0A8C0NHD4 A0A8C0NHD4_CANLF KIND domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AAALRRKARRP;AAGARRAPEHSL;AAGDLLGCR;EDPRDRPDLESI;FGVHVLAGSSSPGGAPDLWACP 5 11.8 1.002 -1.2654 0 7.37903 0 0 9.82987 0 0 0 0 0 0 0 8.70964 0 0 A0A8C0NHD5 A0A8C0NHD5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVAEPALHCPMYFFLG;GEGPVFSGSVT;LLAACLLLLVLPLALILLS 3 12.4 0.99602 -0.092255 0 4.88899 0 0 0 0 0 0 0 0 0 0 10.0692 11.1385 0 A0A8C0NHE3 A0A8C0NHE3_CANLF POF1B actin binding protein POF1B Canis lupus familiaris (Dog) (Canis familiaris) FKLHELTSLLEEKDSLIK;SLHITPNTEQELHSPTV;VLQCQPQHY 3 8 1.0025 -1.0119 0 0 9.129 10.0884 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NHE9 A0A8C0NHE9_CANLF G-protein coupled receptors family 1 profile domain-containing protein LPAR3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] lysophosphatidic acid receptor activity [GO:0070915] HDHSVSQPAIQQDV 1 3.7 0.99078 -0.13569 0 0 0 0 0 0 0 0 10.6558 0 0 0 0 0 0 A0A8C0NHF1 A0A8C0NHF1_CANLF Golgi associated olfactory signaling regulator GFY Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DRPNPDSLPT;SQTSAPASE 2 3.7 0.99645 -0.57592 0 0 0 0 0 0 10.97 0 0 0 0 0 0 0 0 A0A8C0NHF3 A0A8C0NHF3_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EPGDPEEC;PEERASPAE;SSGDGSPPQGRASAAEGAA 3 5.1 1.0031 -1.5225 0 0 5.79312 0 10.1693 0 0 0 0 0 5.91279 0 0 0 0 A0A8C0NHG8 A0A8C0NHG8_CANLF Signal peptidase complex subunit 2 SPCS2 Canis lupus familiaris (Dog) (Canis familiaris) signal peptide processing [GO:0006465] signal peptidase complex [GO:0005787] peptidase activity [GO:0008233] PGGGPTCGSGSG 1 7.6 0.99315 -0.28317 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.5774 A0A8C0NHH0 A0A8C0NHH0_CANLF Fanconi Anaemia group E protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ARRTGSDAGVSVHA;ATVLTKSLFLRRI;ELKPLLLRLP;GQACSWHSGVG;TVLTKSLFLRRI 5 6.4 1.0031 -0.885 0 10.3079 0 0 10.7501 0 0 0 0 0 2.88368 0 0 4.4994 0 A0A8C0NHH2 A0A8C0NHH2_CANLF alanine transaminase (EC 2.6.1.2) Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] ECSQWVPQFPCPPPTP;VYSPDCRFH 2 4.1 0.96146 0.049233 0 0 0 0 0 0 0 0 0 9.20445 0 0 0 0 0 A0A8C0NHI1 A0A8C0NHI1_CANLF Gamma-aminobutyric acid type A receptor subunit alpha4 GABRA4 Canis lupus familiaris (Dog) (Canis familiaris) "gamma-aminobutyric acid signaling pathway [GO:0007214]; nervous system process [GO:0050877]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; postsynaptic membrane [GO:0045211] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237] VSYATAMDW;WFVVFFFFAFFFFF 2 3.4 0.93521 0.060769 0 2.83829 0 0 0 8.47013 0 0 0 0 0 0 0 0 0 A0A8C0NHJ1 A0A8C0NHJ1_CANLF Dickkopf like acrosomal protein 1 DKKL1 Canis lupus familiaris (Dog) (Canis familiaris) LVPVPKAI;PLVLLLLLPSALVPPST;WQPLVLLLLL 3 11.6 0.99177 -0.54508 0 0 0 0 0 8.89757 0 3.74556 0 0 0 0 0 0 0 A0A8C0NHK9 A0A8C0NHK9_CANLF Amino acid transporter Canis lupus familiaris (Dog) (Canis familiaris) L-alpha-amino acid transmembrane transport [GO:1902475] membrane [GO:0016020] symporter activity [GO:0015293] HHLNQKAMKKGEQ;LLGLVTPFATAFAT;LPSMMKCIEENNGV;TASSVGAAG 4 9.7 0.98855 -0.3083 0 11.1819 0 0 0 3.90987 0 0 0 0 0 0 0 10.0916 10.4794 A0A8C0NHM3 A0A8C0NHM3_CANLF Ectopic P-granules autophagy protein 5 homolog Canis lupus familiaris (Dog) (Canis familiaris) ALGELKKLFDAKSEHL;ALKKAQAQLKLPII;DILMPFNLFCKHW;DLWMEYLNMER;ESQQVALDSELLDTMP;GALRLHLMHY;IFEPGSWLE;KLPIIPSLQRLLIYRWAH;LEFWVQALISQHLWYREQPILFLMD;LFFTVVDYVSDETQRHPPTRQFF;LVNCLYPEV;LYQQHKVW;QPNEVGPVAVLE;RLSTLDFKSFGL;SEQKPSTSGP;SHLLLFLHLDSG;TLRNEMKVLLLLS;TVSYQSVLSYFSSHYQP;VNCLYPEVHYLDNI;YEVSYVTLSTRE 20 10.2 0.98941 -0.26592 0 10.6221 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NHN3 A0A8C0NHN3_CANLF G-protein coupled receptors family 3 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LAIIGIVVTIILLLAYLFLLRR;LLQVIIAIEYVTLMMT;LVYVLFLMALTFFI;VGGTNDKG 4 11 0.98822 -0.26458 0 0 0 0 0 0 0 0 12.4191 0 0 0 0 0 0 A0A8C0NHQ6 A0A8C0NHQ6_CANLF Serglycin SRGN Canis lupus familiaris (Dog) (Canis familiaris) granzyme-mediated programmed cell death signaling pathway [GO:0140507]; maintenance of granzyme B location in T cell secretory granule [GO:0033382]; maintenance of protease location in mast cell secretory granule [GO:0033373]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cytokine production [GO:0001818]; protein processing [GO:0016485]; regulation of postsynapse organization [GO:0099175] "extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; mast cell granule [GO:0042629]; postsynaptic specialization, intracellular component [GO:0099091]; Schaffer collateral - CA1 synapse [GO:0098685]" GSGSGSGSGSGFLP;LLLQGSRLVLALALLLVL;NNDFYDNFRP 3 26.4 1.003 -0.88518 6.072 0 9.34623 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NHQ9 A0A8C0NHQ9_CANLF Mitogen-activated protein kinase 8 interacting protein 2 MAPK8IP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of JNK cascade [GO:0046328] cytoplasm [GO:0005737] AACSEEDEEDEED;ACSAACSEEDEEDEED;AEPPQDISLEEFDDEDLSEITDDC;GRACSAACSEEDEEDEEDEAA;LSYDSDHCEKDSL;LVNGEEKE;PGPAQPGPCLFLSN;PMHPGCDCEG;QDDFQEFEMIDDNEEEEEEEEEEEE;QEFEMIDDNEEEEEEEEEEE;QEFEMIDDNEEEEEEEEEEEEEE;SAACSEEDEEDEEDEA 12 12.2 0.97366 0.041303 0 0 0 8.00988 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NHR1 A0A8C0NHR1_CANLF EF-hand domain-containing protein CALN1 Canis lupus familiaris (Dog) (Canis familiaris) perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] calcium ion binding [GO:0005509] GCGCGCGCGA;NTIDSIFWQFDM 2 4.3 1.0031 -0.80196 12.4555 0 0 7.02956 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NHT4 A0A8C0NHT4_CANLF Peptidase S1 domain-containing protein LOC119872343 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DTCAGHGG;DVRTVGLESCRRLY;GESVLYTHPRDSVSAA;SLRRDRHLPYPA;SVSAAVIRVI 5 11.1 1.0032 -1.5552 0 8.70231 0 0 9.32838 5.89564 0 0 4.22095 6.77926 0 0 0 0 0 A0A8C0NHU1 A0A8C0NHU1_CANLF GH84 domain-containing protein OGA Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein metabolic process [GO:0009100] beta-N-acetylglucosaminidase activity [GO:0016231] DYDQKRLFLGPYK;GAAVAGAAGGARRFLCGVVEGFY;LEFYSKLGCFEIAKME;QEPWAFRGGLA 4 7.3 0.98989 -0.31774 0 0 0 0 0 0 0 0 0 0 5.06764 0 11.634 0 0 A0A8C0NHU5 A0A8C0NHU5_CANLF Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein HERPUD2 Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] membrane [GO:0016020] KQDEYHMVHL;LPQAQTDP;PPVTTSAPLGSSSGLG;SDQSGSTTPSSSQE 4 11.2 1.0034 -1.1099 0 0 10.2194 0 0 0 0 0 0 0 5.46336 8.19096 0 0 0 A0A8C0NHV0 A0A8C0NHV0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) CWWECELWQP 1 1.5 0.99109 -0.26939 0 0 0 0 0 0 0 10.0538 0 0 0 0 0 0 0 A0A8C0NHV6 A0A8C0NHV6_CANLF CD1b molecule CD1B Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] AAQEAAGLSCRVK;FQMQYPFEIQGVAGCQLHPD;LPVLIFLIGLLFWLWR;PEAWLSAGPSPGPG;PSPGPGRLQLVCHVSGFYPK 5 23.2 0.96197 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.21956 A0A8C0NHW2 A0A8C0NHW2_CANLF Coiled-coil domain containing 137 Canis lupus familiaris (Dog) (Canis familiaris) GAVPVCPG;PELTAQPRSSAS 2 7.2 0.99071 -0.21186 0 0 0 0 10.1682 0 0 0 12.3739 0 0 11.1284 0 0 0 A0A8C0NHY1 A0A8C0NHY1_CANLF Ankyrin repeat domain 11 ANKRD11 Canis lupus familiaris (Dog) (Canis familiaris) DRGKGDKYRDKSGDKDKSE;EYVTYTGSY;LDRSDGGKEVRERA;LEPLDEGP;PEKHKDKKEKEPAEK;PSCSADDYSD;PVIAPPPSLAEPLKELFKQQEA;PVRKKQEHRK;RQFISWLQDVDDKYDRMKTCLL;SSHGSSAA;TDSEFEKGL;TKRKLPFTVGA;TLSEKKNSFHT;TPSCSADDYSDLMFDCTDPQP;VDDKYDRMK;YEFDEDDEQDRVP 16 7.3 0.97403 0.046925 0 0 0 0 0 0 0 0 8.88996 0 0 0 0 0 0 A0A8C0NHY6 A0A8C0NHY6_CANLF "Saccharopine dehydrogenase (NAD(+), L-glutamate-forming)" AASS Canis lupus familiaris (Dog) (Canis familiaris) L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512] oxidoreductase activity [GO:0016491] GVYDPVEY;PVEYDKYPERYISRFN;RRGLHHKAVM;TTCLINGIYWEQNTPRLL;YEISLGLMPKSIGPLTFV 5 7.6 1.0013 -0.94763 0 0 8.01553 0 8.19017 0 0 0 10.7722 0 0 0 0 0 0 A0A8C0NHZ3 A0A8C0NHZ3_CANLF dipeptidyl-peptidase IV (EC 3.4.14.5) DPP8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] dipeptidyl-peptidase activity [GO:0008239] ESEVEIIHVTSPM;FFISKYSNQKNP;IIYEETTDIWINIHDI;LDYGMYSREEELL;LFQAGSGIYHVK;VLGRHGSN;YEENDESEV 7 10.8 0.98932 -0.52017 10.9078 8.21718 0 0 0 0 10.3922 11.3082 10.1404 0 0 10.2979 8.83033 6.80671 0 A0A8C0NI50 A0A8C0NI50_CANLF HMG box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAGGGGGG;AAGGGGGGGGGGGGGGGAGAGAGG;DEDDEDDEDDDELQ;EAERLRLKHMADYPDYK;FLDEDDEDDEDDDEL;GGGGGGGA;GGGGGGGG;GGGGGGPG;SSSGGGGG;SSSSGGGG;SSSSSGGEDADDLMFDLSL 11 20.2 0.989 -0.30283 0 0 0 0 0 0 6.35833 0 0 9.13681 4.38474 0 0 0 0 A0A8C0NI75 A0A8C0NI75_CANLF Galectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] EALKGPRRGRGEG;GPPESGFLAAV 2 6.2 0.92212 0.095233 0 0 0 0 9.2335 0 7.3699 0 0 0 0 0 0 0 0 A0A8C0NI76 A0A8C0NI76_CANLF Chromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin [GO:0000792]; nucleus [GO:0005634] VIAFYEERLTWHSLE 1 8.7 0.58879 0.37446 0 0 0 0 0 0 0 12.4486 0 0 0 0 0 0 0 A0A8C0NI88 A0A8C0NI88_CANLF UPAR/Ly6 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IVHWGEYRF;KTNSYYFV;VGWPEVTHGIEH 3 10.5 1.0031 -1.5636 8.59805 0 0 0 9.89626 0 9.57067 0 0 9.35288 0 0 0 0 0 A0A8C0NI92 A0A8C0NI92_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GVQMGYRMYDLSSTFYTKPVWKIV;GVSMDKLGAVSH;HYKPPEDDRMLRPFVYQ;LEQAREEWQQQYLAI;NRKFLMEELYQRFLE;RDSVLTKLLQPALGGNSRTTL;SVLAVFQDYVKL 7 11.3 1.003 -0.8774 0 8.95283 0 0 6.95838 0 0 9.51432 11.545 0 8.82706 0 11.1759 9.77684 0 A0A8C0NIA2 A0A8C0NIA2_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EPSPTQQEGPAH;FHKIRSRIVQRTPKTKKSKKFRK;NNKLILAISVTVVVMILIIV;QEKTLPKAKNLRKR 4 7.7 0.91472 0.11121 0 0 7.15076 0 0 0 0 0 0 8.11733 0 0 0 0 0 A0A8C0NIB0 A0A8C0NIB0_CANLF Sema domain-containing protein PLXNB2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] EESGHWLWSR;ELDLQCRDPS;FFVFNQQDKHPPRN;FLPSKDGDKDVMI;LILPLVIVPMVVVIAVS;LKFEEPVSAQEPG;LNHLVVDEASG;RTEAGAFEYVADP;RTEAGAFEYVADPTFENFTGG;RTEGREAF;TQKYYDEIINALE;VDVNGKLGHSPPHVQFT;VGSDLLKFEEPVSA;VLGELPLEIYYGGSRVPSP;YDCREAMSLAEN 15 10.3 0.99875 -3.2686 0 11.4677 9.17685 10.2251 0 8.69213 10.7243 0 12.6451 9.42997 9.375 10.6942 0 0 9.93898 A0A8C0NIB2 A0A8C0NIB2_CANLF Lysosome-associated membrane glycoprotein 2-like luminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765] ESTGSPGTTS;ISLGLLALALVTFCIIRRRPPTY;LVGLLAAQ;TGTTGTGKPHTSTSY 4 17.8 1.0014 -1.315 0 0 0 7.59447 0 0 0 0 0 0 0 0 4.44771 10.1699 0 A0A8C0NIC0 A0A8C0NIC0_CANLF F-BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGKSKGKL 1 2.5 1.004 -1.1044 0 4.07219 0 0 0 0 0 0 0 0 0 0 0 7.6527 0 A0A8C0NID0 A0A8C0NID0_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] plasma membrane [GO:0005886] protein tyrosine phosphatase activity [GO:0004725] DDGSGSVLRIQPLRTPRDEAIYECV;DINIPLLPL;EPHFYPSI;SLPETFGDFWRMIWEQRSATVVMM;STATSITLT 5 3.8 1.0039 -1.038 10.3567 0 0 0 0 0 0 0 9.38899 0 0 7.53652 0 0 0 A0A8C0NIE4 A0A8C0NIE4_CANLF Plexin A2 PLXNA2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] AIVSIAAGGSLLLIIVIIVLI;APLRMEQRRPW;DRGSKMVSEIYL;EFNMLSALNEI;GKLKKIRA;MVTITGHYLGAGSSVAVYLGNQ;SLVVSDAPDLSV 7 5.1 1.0019 -1.4645 0 8.67518 0 0 0 0 0 0 0 0 0 0 0 6.41469 6.46796 A0A8C0NIF2 A0A8C0NIF2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) LOC100686262 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] NSTDESTDCCVSSGDL;VGSVLSCSTIPPELV 2 5.8 0.94092 0.10312 0 0 0 0 0 0 0 0 0 0 6.54012 11.5439 0 0 0 A0A8C0NIF4 A0A8C0NIF4_CANLF Alpha-carbonic anhydrase domain-containing protein CA8 Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] WNSTLFGSIDEAVG 1 9.2 0.98351 -0.2444 0 0 0 0 0 0 0 0 12.1122 0 0 0 0 0 0 A0A8C0NIF7 A0A8C0NIF7_CANLF S100P-binding protein S100PBP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] calcium-dependent protein binding [GO:0048306] PKWQHPSDLTMRNYARFRQKPL;RNYARFRQKPLQRYSLTQWVDRNM 2 8.3 0.94326 0.088001 0 0 0 0 0 0 0 0 0 0 0 0 0 9.10693 7.26294 A0A8C0NIG3 A0A8C0NIG3_CANLF E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; RQC complex [GO:1990112] ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ATYTIEDIVIELIIQLPSNYPLGSI;CLLPENELDSL;DEQLFNHLAETLSSW;IFLTGFCEMLQKMNITY;LLQLLFSRSMEH;LPKKACRTC;LSNKDPKTFFTE;LSQSVSSDEVKRHYRRKEGFF;LSSWEAKVDVEKDDKTAHS;MVRLWWNSSEKRVFN;SCLQTRSIDDG;TYTIEDIVIE;VLRKLSKKDV 13 9.8 0.97821 0.047716 0 0 0 7.87732 0 8.12763 0 0 0 0 0 0 0 0 0 A0A8C0NIH1 A0A8C0NIH1_CANLF Cathepsin L1 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603] extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197] SATGAFEG;YFDPDCSSKDLDHG;YHCIFFFTFTL 3 11.1 1.0029 -1.34 0 0 0 0 0 0 0 0 0 0 0 0 7.88746 0 13.8555 A0A8C0NII4 A0A8C0NII4_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] FHETLNCCGSSTLSALTT;GAVMMFVGFL;LPWMTRIFKPGRLAVR;LTTSMLKNSLCPSGSN 4 10.9 1.0022 -0.76511 9.6275 0 0 0 0 0 7.27342 0 0 10.2851 0 0 7.33584 0 0 A0A8C0NII6 A0A8C0NII6_CANLF ABC transporter domain-containing protein ABCA15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GTLLLTRKLLII;HIVMVKEAHCNVEEIFKLLQY;IPVYWLSALLWD;METDHMLAAFNLLDKHNA;TLWKLRTFFNQYVYFGIYKTF;VIILLMCMIFFV;VPMIFPGAWEL 7 6.9 0.97624 0.047759 7.61861 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NIJ8 A0A8C0NIJ8_CANLF Bromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DIEISLYTVEKKKKPSY;KKPSYTTQRV;SSGRRVSRRQSLKSNPD;TIRRRLENRFYRRISALMWEVRYIE;VGIKYEVGPPTLCCLKLAFLD;VLQYFGIYCLQIF 6 7.4 0.98663 -0.45893 0 0 0 9.55572 0 0 0 0 0 0 0 0 0 12.2423 0 A0A8C0NIK1 A0A8C0NIK1_CANLF Cerebral endothelial cell adhesion molecule CERCAM Canis lupus familiaris (Dog) (Canis familiaris) AGSSGHSLHP;DLAGSSGHSLHPH;GDAEWLSDTETSSPW;LVFEDDVRFESNFRGRLERLMEEVE;VEAEKLPWDL 5 10.3 1.0021 -0.74069 6.94122 0 0 0 0 0 12.5333 0 0 7.83788 0 0 0 0 0 A0A8C0NIL4 A0A8C0NIL4_CANLF Zinc finger and SCAN domain containing 25 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RVTSERFGEATLQSPE 1 3.7 0.99054 -0.21069 0 0 0 10.707 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NIM9 A0A8C0NIM9_CANLF Voltage-dependent L-type calcium channel subunit alpha CACNA1F Canis lupus familiaris (Dog) (Canis familiaris) detection of light stimulus involved in visual perception [GO:0050908] voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AFRVLRPLRL;AISVVKILRVLRVLRPLR;AVIGMQMF;GAGMEEEEEEEEGEEEEE;GVLVAGGENEEEEGRK;IFTIPEEG;ISVVKILRVLRVLRPL;ISVVKILRVLRVLRPLRAI;KRLVAMNMPLNSDG;LGISVLRCVRLLRIFKVTRHW;MRLVKLLSKGEGIR;NRNNNFQTFPQAV;QAEELDLEDPSTDGNFG;SAISVVKILRVLRVLRPLRA;SVVKILRVLRVL;SVVKILRVLRVLRPLRAINRA;VIFGSFFVLNLV;VLRVLRPLRAINRAKG;VVQCVFVAIR;YGGPFFPGMLV;YIPKNPHQYRVWATVNSAA 21 11 1.0029 -2.5537 12.9993 8.95184 6.87958 9.50875 8.34292 4.4221 11.7335 10.4868 10.5667 5.96597 2.83013 9.64503 0 9.49673 0 A0A8C0NIN5 A0A8C0NIN5_CANLF Ligand dependent nuclear receptor interacting factor 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nuclear retinoic acid receptor binding [GO:0042974] SMPIKDNALVMFNGK;SPYILVNTQSLPMT;VSPDIPPRNDTSQ 3 6.1 0.99638 -0.095018 0 7.20975 0 10.2312 0 0 0 0 0 0 0 0 9.37369 0 0 A0A8C0NIN7 A0A8C0NIN7_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" SSLAWPSVSPPPMC 1 6 0.98328 -0.25628 0 10.3637 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NIP3 A0A8C0NIP3_CANLF Histone-binding protein RBBP4 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; regulation of DNA-templated transcription [GO:0006355] "chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; NuRD complex [GO:0016581]" histone binding [GO:0042393]; nucleosome binding [GO:0031491] DKEAAFDDAVEERV;LVMTHALEW;QLPNDDAQF 3 7.8 0.98657 -0.41023 0 0 0 9.76984 0 0 0 0 0 0 0 0 10.5661 0 0 A0A8C0NIP4 A0A8C0NIP4_CANLF Roundabout guidance receptor 3 Canis lupus familiaris (Dog) (Canis familiaris) GDCCPAFSTGPG;GDPGAWSQ;GPEEDLEGSS;MMPASAPS;PAPYPWLADSWP 5 7.3 1.0027 -1.3762 0 0 0 0 0 7.86214 0 8.78735 0 0 0 0 0 0 0 A0A8C0NIQ2 A0A8C0NIQ2_CANLF "FOS like 1, AP-1 transcription factor subunit" FOSL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AQTPTSGQQETD;PVLEPEALHTPTLMTTPS 2 18.1 0.72274 0.25969 0 10.3571 0 0 0 0 0 0 0 11.1962 0 0 0 0 0 A0A8C0NIQ4 A0A8C0NIQ4_CANLF Ubiquitin-like protease family profile domain-containing protein SENP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] nucleolus [GO:0005730] cysteine-type peptidase activity [GO:0008234] EDEDEEEE;SFDASASEEEEEEEEDEDED;SGGGFGPD 3 5.8 1.0033 -1.0562 0 0 9.1375 3.80787 0 0 0 0 6.07823 0 0 0 0 0 0 A0A8C0NIQ5 A0A8C0NIQ5_CANLF Butyrophilin-like protein 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GWREHQAK;LDYEDNDFSFYDMTEG;VTVNMEIFH 3 6.9 0.98576 -0.42938 0 0 7.65607 0 0 0 0 10.3395 0 0 0 0 0 0 0 A0A8C0NIQ6 A0A8C0NIQ6_CANLF Vang-like protein Canis lupus familiaris (Dog) (Canis familiaris) "establishment of planar polarity [GO:0001736]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" plasma membrane [GO:0005886] ENSTNNSTGQSRAVI;ESILQHLEFCIT;ETWSPSLQ;FQVLLGMAETWSPSLQ;HERRVRKRRARLV;ISVAFKLLILLL 6 11.8 0.54872 0.41461 0 0 0 0 0 7.72185 0 0 0 9.38765 0 0 0 0 0 A0A8C0NIR7 A0A8C0NIR7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEDEADYYCQSLDD 1 8.9 0.93968 0.060769 0 0 0 0 0 0 6.50085 0 0 0 0 0 0 0 0 A0A8C0NIT4 A0A8C0NIT4_CANLF Neurobeachin Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] ANRTSVMFNFP;GAGGGGGG;GGGGGGGG;GGGGGGPG;HLISAAKHRDHVT;HSFYKETPATF;IAECGPEPIPYPDP;ITDPVLREAMEAQI;KTFRSQAIVNQNAE;KTPLESVPGNLSPI;LLVGGEFD;MLGVLASYSITVK;NDSYDKCFL;PVFPWVLTNYESEEL;QLHDFWRLDYWEDDLRRRRRFVRN;SGSSSSSSSSSFVNGATS;SVNLDSITDPVLREAME;TDLLFALETDVHVW;VGGENGALVEVES;VINPADSSGITPKGLD;VPIRNIRMKFAVLIG 21 9.1 1.0034 -2.2523 12.5131 12.9519 12.4868 13.4267 13.6157 13.7038 14.3192 14.3137 14.2567 13.5531 13.6006 13.6678 14.0349 14.2983 14.0179 A0A8C0NIU5 A0A8C0NIU5_CANLF Poly(ADP-ribose) polymerase family member 9 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] GLQVIKVEKI;LGHPHEQRGRRAEGHGSGP;RQRGPRFGSPAVGA;WTATDCDACIHK 4 5.3 1.0029 -0.85343 0 0 0 0 0 0 6.22439 9.09698 0 0 0 0 0 0 0 A0A8C0NIU6 A0A8C0NIU6_CANLF Transcription factor AP-2 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700] PCTPATLRS;PSRHLRAAARAA 2 7.9 0.99074 -0.19584 0 10.4772 0 0 0 0 0 0 0 0 0 0 9.28503 0 0 A0A8C0NIV2 A0A8C0NIV2_CANLF SET nuclear proto-oncogene Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] TLTLEAKV 1 4.3 0.9846 -0.25882 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4578 A0A8C0NIW1 A0A8C0NIW1_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] CatSper complex [GO:0036128] calcium-activated cation channel activity [GO:0005227] DEIVDTAFESPCFGEEGPSGPG;EIVDTAFESPCFGEEGP;GVHHHHESHHHSGSPHH;HHHGGSPH 4 5.8 1.0035 -1.5953 0 0 4.42385 0 0 0 9.17505 0 0 0 8.67589 7.61279 0 0 0 A0A8C0NIW2 A0A8C0NIW2_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] SPLLSSSFDLDY;YYNRMYSFPACV 2 12.6 0.95393 0.05044 0 0 0 6.08806 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NIW3 A0A8C0NIW3_CANLF "Zinc finger protein, FOG family member 1" Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] EAAGAATPEAEAEAEG;EIYSVGPPPPLPSLA;PSPGLDRKALTEA 3 4.5 0.99303 -0.16641 0 0 0 0 0 0 0 0 9.73383 0 0 0 0 0 0 A0A8C0NIX7 A0A8C0NIX7_CANLF Dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) POMT1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169] ISFYMKRIFF;LIENALITQSRLILLE;LSWWFWLML 3 4.7 0.99646 -0.57964 0 0 0 0 5.15287 0 0 0 0 0 0 0 0 0 0 A0A8C0NIY6 A0A8C0NIY6_CANLF APC regulator of WNT signaling pathway 2 APC2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] cell periphery [GO:0071944]; intracellular membrane-bounded organelle [GO:0043231] beta-catenin binding [GO:0008013]; microtubule binding [GO:0008017] AELLQVDY;GAGGRNGA;GGGGGGGG;GGGGGGPG;GPAAGDQELELLRECLGAAVPARL;LSKVPEKLAAEAVPL;PARVDDSAEGT;QRAQIRASRLEQ;QTEPQALLAAKSVP;SPGACAPSLYVRKQRAL;VAAGGFPA 11 5.6 1.0033 -2.1357 0 9.5207 11.0735 0 0 0 0 7.77406 5.93734 10.7819 0 8.88188 11.4387 1.03337 11.256 A0A8C0NIZ0 A0A8C0NIZ0_CANLF Cadherin-1 (Epithelial cadherin) CDH1 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; catenin complex [GO:0016342]; endosome [GO:0005768]; flotillin complex [GO:0016600]; Golgi apparatus [GO:0005794] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AILGILGGILALLILILLLLL;ALLILILLLLLFVRRRR;ALLILILLLLLFVRRRRVV;GILGGILALLILILLLLLF;GQEITSYTAEDPDTY;ILALLILILLLLLFVR;ILGILGGILALLILILLLL;ILGILGGILALLILILLLLL;LALLILILLLLLFVR;LALLILILLLLLFVRRRR;LALLILILLLLLFVRRRRV;LGGILALLILILLLLLFVRR;LGGILALLILILLLLLFVRRRRVV;LGILGGILALLILILLLLLFVR;LILLLLLFVRRRRVVKEPLL;LLILILLLLLFVRRR;LLLPLLLLL;LLLPLLLLLQ;LLPSSMMFT;PAILGILGGILALLILILLLLL;QVPAILGILGGILALLILILLL 21 8.6 0.99254 -0.28215 7.08969 5.74996 7.81429 8.01452 6.26159 0 0 6.45111 7.60437 11.2816 11.5554 0 9.68773 8.60511 8.65796 A0A8C0NJ06 A0A8C0NJ06_CANLF Rho GTPase activating protein 21 ARHGAP21 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] anchoring junction [GO:0070161]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; Golgi membrane [GO:0000139] GTPase activator activity [GO:0005096] ADFIEANR;ESPRPPGAPRPTP;FSQNSLVSVKDQRPVNH;PDRQEPTW;QTYKWSGFTEQD;RLEPMDTIFVKQ;RMEERKASSTSPPG;YTGIYRVPGNNAAISSMQEEL 8 5.4 1.0012 -0.94129 0 4.51791 5.44844 12.6586 0 5.67754 10.499 0 10.7205 5.50507 7.09329 6.37634 9.65222 9.92529 0 A0A8C0NJ17 A0A8C0NJ17_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DQPSWNRDHD;EQGDGLDNSVASPSTGDDDDPD;HVDMILCSPGAVSCPSV;KRHKKRGIFPKVATN 4 12.9 0.97641 0.046227 0 0 0 0 0 0 0 9.11014 0 0 0 0 0 0 0 A0A8C0NJ39 A0A8C0NJ39_CANLF Histone deacetylase complex subunit SAP18 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nuclear speck [GO:0016607] transcription corepressor activity [GO:0003714] TCPLLLLLLRVF 1 7.7 0.95491 0.05044 0 0 0 0 0 0 0 0 0 0 3.92229 0 0 0 0 A0A8C0NJ44 A0A8C0NJ44_CANLF Uncharacterized protein C15H1orf109 Canis lupus familiaris (Dog) (Canis familiaris) DEHQSLVQV;PAYTGGGG 2 5.8 1.0018 -1.429 0 0 0 8.06948 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJ55 A0A8C0NJ55_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DRLYKREKDHPLRRE;GVHVDCVQLLLEAGSSVN;LAVAARSNHTSLV;LTALHAAA;WLHGVAVASENP 5 16.8 0.98933 -0.52119 0 0 0 11.5075 0 0 8.03672 0 9.81777 0 0 0 5.926 0 0 A0A8C0NJ69 A0A8C0NJ69_CANLF Matrin-type domain-containing protein CIZ1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] VPMNPSQI 1 1.1 0.98935 -0.2632 0 12.1486 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJ72 A0A8C0NJ72_CANLF Myelin transcription factor 1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DDDDDEEE;DDEDGEDVEDEEEDEEEDDDD;DEEGDREEEEELEEEEDDDDED;EDDDDDEEE;EDDDDDEEEEDNEDHQMSC;EDEEEEFSEDED;EDVEDEEEDEEEDDDDDE;EEEDDDDE;EEEDEEEDDDDDEEEEDNEDH;ESDEEVCLSSLECLRNQCFD;LEEEEDDDDEDG;QELKCPTPGC;RQEDDFAGRTPDRNYSDMMNLMRL;SETNPQDRSQQQ;TAILNLSTRCREM 15 12.8 0.85593 0.19205 0 5.82584 0 0 5.31019 0 0 5.51753 0 0 0 0 0 7.21694 0 A0A8C0NJ82 A0A8C0NJ82_CANLF C2H2-type domain-containing protein ZNF280D Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KDLRLTSADV;KVIKIATPYMHHYMKHQK;LSFETEHILLQHMKD;NSKMAELFMECE;QHCYRQFPTPFQLQ;QSKNGTPFPRACPKCN;SEIKDFAN;SESWENHTTCQHCYRQFP;SSESWENHTTCQHCYRQF 9 11.3 1.0033 -1.6233 0 11.0068 9.46628 0 3.46271 9.27989 3.80478 0 9.68345 0 2.86449 0 0 9.75942 8.20672 A0A8C0NJ90 A0A8C0NJ90_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DQPSWNRDHD;EQGDGLDNSVASPSTGDDDDPD;HYGGMDGVGIPSTMYGDP;KRHKKRGIFPKVATN;SLKGKLLRRDS 5 15.1 1.0025 -1.0106 0 0 0 0 0 0 6.68972 0 6.6246 3.2474 0 0 7.32283 5.20304 13.049 A0A8C0NJB2 A0A8C0NJB2_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] LSSGLEGFLVE;SSGLEGFL 2 6.5 0.99421 -0.081387 0 0 0 0 9.48121 0 0 8.28161 8.73671 0 0 0 0 0 0 A0A8C0NJC3 A0A8C0NJC3_CANLF Golgin subfamily A member 7 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane protein transport [GO:0043001]; protein targeting to membrane [GO:0006612] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; palmitoyltransferase complex [GO:0002178] SFAAGRKWRC;SGKVFIQRDYSSG 2 8.7 0.99039 -0.2103 0 0 9.40601 8.95143 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJC4 A0A8C0NJC4_CANLF Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) DBT Canis lupus familiaris (Dog) (Canis familiaris) branched-chain amino acid catabolic process [GO:0009083] cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial nucleoid [GO:0042645] acyltransferase activity [GO:0016746]; branched-chain alpha-keto acid dehydrogenase activity [GO:0047101]; ubiquitin protein ligase binding [GO:0031625] ATMSRFSNLWKSYLEN;AVSHDEHTHQEIK;KYSHPHQLLQT;PEVAIGALGSIKALPR;PPTPKGKV 5 13.3 1.0016 -1.2575 0 6.04433 0 0 0 0 0 10.2259 0 0 0 8.04772 0 8.26167 0 A0A8C0NJD2 A0A8C0NJD2_CANLF Myelin transcription factor 1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DDDDDEEE;DDEDGEDVEDEEEDEEEDDDD;DDEEEEDNDPS;DEEGDREEEEELEEEEDDDDED;EDDDDDEEE;EDDDDDEEEEDNDP;EDEEEEFSEDED;EDVEDEEEDEEEDDDDDE;EEEDDDDE;LEEEEDDDDEDG;QELKCPTPGC;TAILNLSTRCREM 12 10.2 0.92969 0.09626 0 3.89317 0 0 0 0 8.27151 0 0 0 0 0 0 0 0 A0A8C0NJD9 A0A8C0NJD9_CANLF Calpain catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] AGKSPIFHFFEDPEGKIELPP;DETTIISQPDISQ;DLQTAHYPI;QFLEISSPFLNYRMTPF;SYIFFNMLEKADAKDI;VISLHPGYVDKVWELLK 6 6.6 0.96454 0.049233 9.92309 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJG5 A0A8C0NJG5_CANLF Anthrax toxin receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023] DLYFVLDKSGSVA;EQCMDQYV;PGGPVSAQ;RRQYDRVSLMRPQE;VLCTYTVNE;VPGLWPPLLPLLLLPLLRAPGGPV 6 13.4 1.0036 -1.0578 13.1519 0 0 0 0 0 0 9.24444 12.8438 13.1554 0 9.53382 12.3882 11.9383 8.20535 A0A8C0NJG7 A0A8C0NJG7_CANLF Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) Canis lupus familiaris (Dog) (Canis familiaris) thiamine metabolic process [GO:0006772] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; thiamine triphosphate phosphatase activity [GO:0050333] DTEDRLQELGGTLEHRVTFRD 1 9.1 0.97403 0.048189 0 0 7.30916 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJH1 A0A8C0NJH1_CANLF Folate receptor-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EQWWEDCRTSYTCRS;WGAAGPPA 2 7.7 1.0043 -1.1044 0 0 0 0 0 7.99135 0 0 0 0 0 0 0 0 0 A0A8C0NJI4 A0A8C0NJI4_CANLF FERM domain containing 5 FRMD5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLFVLLLLLI;MGPRLHGR;RLLLVTMGLLFVLLLLLIILT;VLRLLLVTMGLLFVLLLLLII 4 12.1 1.0044 -1.1044 0 0 0 0 0 0 0 8.32265 0 0 0 0 0 0 0 A0A8C0NJJ8 A0A8C0NJJ8_CANLF Keratin-associated protein 9-3-like LOC102151268 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCSYCCQPTC;CCQPSCCQTSCCHCCQP;CCQTSCCHCCQPS;CCQTSCCHCCQPSCGTGCGIG;CCQTSCCHCCQPSCGTGCGIGG;CGSSCCQPSCCQTSCCHCCQPSC;CGSSCCQPSCCQTSCCHCCQPSCG;CQPSCCQTSCCHCCQ;CQTSCCHCCQPSCGTGCGIGGGQEG;CRPSYCGQSCCRPA;GSSCCQPSCCQTSCCHCCQPS;NCGSSCCQPSCCQTSCCHCC;QTSCCHCCQPSCGTGC;SCCHCCQPSCGTGCG;SCCQPSCCQTSCCHCCQ;SGNCGSSCCQPSCCQTSCCH;SSCCQPSCCQTSCCHCCQ;STSGNCGSSCCQPSCCQTSCCH;STSGNCGSSCCQPSCCQTSCCHCCQ;TCSTSGNCGSSCCQPSCCQTSCCHC;TSGNCGSSCCQPSCC 21 49.3 0.28244 0.65871 0 8.89754 5.36859 3.90872 6.9939 0 4.50602 8.32197 8.34846 6.39215 0 0 8.36798 10.6636 11.0998 A0A8C0NJL5 A0A8C0NJL5_CANLF Tetraspanin 15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ITRVEDIIMEH;SCSEDQLSLWRWWCWEG;TAESPFLTTDWPQR 3 10 0.99493 -0.17366 0 8.90509 0 0 6.10624 0 9.14977 0 0 5.98805 0 0 0 0 0 A0A8C0NJP0 A0A8C0NJP0_CANLF Filaggrin Canis lupus familiaris (Dog) (Canis familiaris) establishment of skin barrier [GO:0061436] cornified envelope [GO:0001533]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634] DTESHSGVPQAHSGSPRGQAGS;GVRQSHSGSP;NMESQDPQYKGD;PESSLFRSTRIY;SEDISAHAHA;SRSQGIIFSHS;TESGHGQATRT 7 3.3 0.98903 -0.21895 0 0 0 0 0 0 0 0 0 0 0 5.7535 10.4941 0 0 A0A8C0NJP6 A0A8C0NJP6_CANLF Doublecortin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] QVEVPVDQVGS;VGSRCRVTVPS 2 5.2 0.98596 -0.43401 0 0 0 0 10.3728 0 0 0 14.8087 0 0 0 0 0 0 A0A8C0NJQ3 A0A8C0NJQ3_CANLF V-SNARE coiled-coil homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVGLLIILIVLLVIFLPW;IYLGLVVGVGLLIILI;IYLGLVVGVGLLIILIVLLVIFLP;LGLVVGVGLLIILIVLLVI;LLIILIVLLVIFL;LVVGVGLLIILIVLLVIFL;VGLLIILIVLLV;VGLLIILIVLLVIF;VGLLIILIVLLVIFL;VGLLIILIVLLVIFLP;VGLLIILIVLLVIFLPW;VGVGLLIILIV;VGVGLLIILIVLLVI;VGVGLLIILIVLLVIFLPW;VVGVGLLIILIVLLV;VVGVGLLIILIVLLVIF 16 25.8 0.94174 0.087507 10.5691 0 10.3279 0 0 5.29359 8.31433 3.10187 0 4.82975 6.41273 7.1079 5.57419 9.16068 11.1604 A0A8C0NJS5 A0A8C0NJS5_CANLF MutL homolog 3 MLH3 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] mismatch repair complex [GO:0032300]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] ATMKYDSNNSCQPV;EALSLMHPSI;FKVATEMGC;GDDLEIQN;KVATMKYDSNNSCQPVS;LIEALSWCQLPFQCAHGRPSML;LIEFQDWDTVLVCIQ;PSMLPLADIDHLGQEKQIKPNL;VDVLHENDTVDDT 9 8.1 0.99951 -2.8943 0 6.06839 0 0 0 0 0 10.4821 0 9.89086 0 0 0 0 12.514 A0A8C0NJU3 A0A8C0NJU3_CANLF Repulsive guidance molecule BMP co-receptor b Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] LFPGGGGP;QGGVALAACGALGAGRGV 2 3.4 1.0032 -1.382 0 0 0 0 0 0 0 0 0 0 0 0 7.86648 0 0 A0A8C0NJW3 A0A8C0NJW3_CANLF Ribitol-5-phosphate transferase FKTN N-terminal domain-containing protein FKTN Canis lupus familiaris (Dog) (Canis familiaris) PGAFDRPELQ;TSHGSTSECKFFCV 2 6.4 0.98798 -0.47122 0 0 0 12.3872 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NJW7 A0A8C0NJW7_CANLF Meiosis-specific nuclear structural protein 1 Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] axoneme [GO:0005930]; motile cilium [GO:0031514]; nucleus [GO:0005634] EMLRQREDL;LGEEFRKAYQKRSEICGE;PAASNERPRLRRWAGPRWGR 3 7.6 0.98751 -0.40278 0 0 0 0 0 0 0 0 0 0 10.479 7.86202 0 10.5112 0 A0A8C0NJX2 A0A8C0NJX2_CANLF PID domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] cytoplasm [GO:0005737] PKYLSTGLPRNPR 1 3.1 0.93856 0.059582 0 0 0 0 0 0 0 0 0 0 0 0 0 9.41523 0 A0A8C0NJX5 A0A8C0NJX5_CANLF Coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AQVLIVVVITPILVCRDFAVL;DQPQSRRARELGSGV;GDRPAAPS;PESSGSSAYGDSYYYEN;TDPQPPPPPGSQAQLQT 5 9.1 1.0023 -0.90247 8.44402 0 0 0 0 9.38321 6.54864 0 0 0 0 0 0 0 9.77683 A0A8C0NK00 A0A8C0NK00_CANLF Nucleoporin 214 NUP214 Canis lupus familiaris (Dog) (Canis familiaris) ETAETKTLEMLDRL;FGGTSATT;GSVSSKSSVSPSAS;LEWDRHLEQKRKQKRLLVPERETL;QLRLYNQTSQ;SAPTLPVASG;SLLQIKQVASVLLQCLAALLLL;SLPQAPLQ;SLPSDVTSQ;STLKTTLLEG;VEEAREQNERDCDS;VGTSEEMKMLRTESDDLHTFLLE;YYLSYIEEWDLVL 13 7.8 0.99923 -3.2107 0 0 10.3628 11.4523 0 10.0692 0 4.01078 10.4774 0 6.32567 6.07555 13.7126 0 0 A0A8C0NK01 A0A8C0NK01_CANLF G3BP stress granule assembly factor 2 G3BP2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; intracellular organelle [GO:0043229]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] DLEQNESDN;EDEVFGDSEPELDEESED;GPAAVGDP 3 5 1.0022 -1.8603 0 6.04767 0 0 0 0 0 6.04428 9.03694 0 0 0 0 0 0 A0A8C0NK09 A0A8C0NK09_CANLF N-acetylglucosamine-1-phosphate transferase subunit gamma GNPTG Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] LVYPALPPAL;RQSKVELACGSSHR 2 7.8 0.98419 -0.24403 0 0 0 0 0 0 0 8.81689 0 0 0 0 0 0 0 A0A8C0NK61 A0A8C0NK61_CANLF "NPL4 homolog, ubiquitin recognition factor" Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] HCVPLEPFDED;VGWIFTDLVSE;YGRYTEHKDI 3 5.6 0.98723 -0.23064 0 0 0 0 0 10.8717 0 0 0 0 0 0 0 0 9.28887 A0A8C0NK63 A0A8C0NK63_CANLF Pyruvate kinase (EC 2.7.1.40) PARP6 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to insulin stimulus [GO:0032869] cytoplasm [GO:0005737] ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] DENILWLDYKNICK;QVKQKGADFLVTEVENGGSL;VGAWLGARASTCL;WSSGAELPTSLSSHPG 4 10.7 0.98789 -0.22561 0 0 0 0 0 3.04469 0 0 0 0 0 0 0 0 0 A0A8C0NK74 A0A8C0NK74_CANLF Growth factor receptor bound protein 10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FSGQTGRVIENPAEAQSA;GLEESSVFSL;LFCFDDVD 3 7.7 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 10.1805 0 0 A0A8C0NK80 A0A8C0NK80_CANLF Prostaglandin E2 receptor EP3 subtype (Prostanoid EP3 receptor) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] GTGAPRDR;YLLLRKILLRKFCQLRKR 2 5 1.0027 -1.3857 5.48146 0 0 0 0 0 0 0 6.32357 0 0 0 0 8.39862 4.55287 A0A8C0NKB3 A0A8C0NKB3_CANLF Integrin subunit alpha 8 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] ILAILLGLLVLAILTLALWK;LNYYRENTVT;LWVIILAILLGLLVLAILTLALW;NPMVAGTNYSL;RARGGADSSPTQWPG;SDIDRNDYPD;VIILAILLGLLVLAILTL;YNGNKDGLNRKPSQILQGMWASQT;YTVTVSDVN 9 8.5 1.0027 -0.87082 0 0 0 0 0 0 6.51901 8.92573 11.1346 0 0 0 15.6353 0 8.56323 A0A8C0NKC5 A0A8C0NKC5_CANLF Transmembrane protein 245 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALGAQRGTTTSTMPRA;ERQEALAPWPVVGLGKF;GEQALRRRRLLLLLGAGGPL;GGGGGGGE;GGGGGGGG;IIFLLVIGTLLLALLLT;LGEQALRRRRLLLLL;PGGGGGGG;SSNIIGQSVEEAISFSSNP;VPIAVWILKKLV;WFVKNVTHS 11 13.9 0.95154 0.049862 0 0 0 0 0 9.10988 0 0 0 0 0 0 0 0 0 A0A8C0NKD0 A0A8C0NKD0_CANLF Cleavage stimulation factor subunit 2 hinge domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGAKPGPV;GAPATGAH;LALRILHRKVHVTP;PGAHGEAAAAIFTAVS;RQPREPRVGEQ;VGEQRQPREPR 6 8.3 1.0014 -2.6591 0 0 8.2416 10.4986 0 0 0 9.7704 0 0 0 0 0 0 0 A0A8C0NKD2 A0A8C0NKD2_CANLF PH domain-containing protein PLEKHO2 Canis lupus familiaris (Dog) (Canis familiaris) ENEVSDIKF;LDLEVPDSGPP;VTRDRVRGG 3 5.7 1.0018 -1.2844 0 0 0 0 0 0 0 0 0 8.3415 9.34354 0 8.732 0 0 A0A8C0NKF8 A0A8C0NKF8_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EAPLTLSEDVN;EAPLTLSEDVNLV;GAGKACAS;HCVELEGLEAATL;TAPWLGGSVPISPD 5 16.5 1.0044 -2.0179 0 0 0 10.8891 0 0 0 8.81211 10.1227 0 0 0 0 0 0 A0A8C0NKG4 A0A8C0NKG4_CANLF "10 kDa heat shock protein, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein folding chaperone [GO:0044183] VGDKVLLSE;VGSGPKGK 2 16.8 1.003 -1.9086 0 0 0 0 0 0 10.4357 0 8.95922 0 0 0 0 0 0 A0A8C0NKG7 A0A8C0NKG7_CANLF [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) KDM5A Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] DKLLLCDGCDDSY;EQSVLAHI;LDEVRLTLSDPQQ;PERLVCLYHPNDLCPC;TVSERWEEKAKVCLQ;VGMCFSSFCWHIEDHWSYSINYLHW;YHSGFNQGYNFAEAVNFC 7 6.6 0.92748 0.10638 0 0 0 0 9.67894 8.06846 0 10.4941 11.9743 0 0 0 9.7276 0 0 A0A8C0NKH1 A0A8C0NKH1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AARAHLSSGGGRKGG 1 9 0.95084 0.053898 0 0 0 0 0 0 0 0 0 0 8.93837 0 0 0 0 A0A8C0NKM2 A0A8C0NKM2_CANLF GTP-binding protein 1 GTPBP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] EQYDSLLRQMWER;KKIKRSSIRKGMVMVS;LSEADMEASYA;LVSPTSEQYDSLLR;SVPGVGTVVSGTTLRGLIKL;TLKLLQRLLKSP 6 12.8 0.99585 -0.19 12.2184 0 0 0 11.3289 0 0 11.9258 0 0 0 8.42463 0 4.27665 0 A0A8C0NKN0 A0A8C0NKN0_CANLF Hydroxysteroid 17-beta dehydrogenase 14 HSD17B14 Canis lupus familiaris (Dog) (Canis familiaris) steroid catabolic process [GO:0006706] cytosol [GO:0005829] estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] DLCWSNLFFH 1 3 0.9896 -0.26223 0 0 0 0 0 0 11.3949 0 0 0 0 0 0 0 0 A0A8C0NKQ0 A0A8C0NKQ0_CANLF Harmonin-binding protein USHBP1 PDZ-binding domain-containing protein USHBP1 Canis lupus familiaris (Dog) (Canis familiaris) SREEELIRMQASLQ;VPSQESCEPRLQGPE 2 4.1 0.98642 -0.41978 0 0 0 0 0 0 0 0 12.9911 0 0 0 0 0 0 A0A8C0NKQ7 A0A8C0NKQ7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;LHCWWECELVQPLWKTVE;MDAFLESHKL;MNEKGEITTNT 4 5.8 0.972 0.048313 0 0 0 6.97177 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NKS3 A0A8C0NKS3_CANLF Olfactory receptor OR11I1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EQRTISVAGCMAQF;ILIVLLVLFIHHLH;LVFYVLVISGNILIVLLVL;VEFMLQGFSSI 4 15.8 0.98697 -0.40835 0 0 0 0 0 0 0 0 0 4.5825 0 0 11.7554 0 5.24184 A0A8C0NKT0 A0A8C0NKT0_CANLF Rap guanine nucleotide exchange factor 4 RAPGEF4 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] DILHFPLKRHIRR;DWELFNCVHELELIYHTFGRHNF;KDMTFTHEGNKTFID;LKRHIRRLLIVT;NEIQFWVVTE;RQLNVIDNQR;VFMPNTQL;VGTELVDWMLQQT 8 10.7 0.91602 0.11002 0 0 0 0 0 0 0 0 0 0 3.35572 0 0 5.15502 0 A0A8C0NKU2 A0A8C0NKU2_CANLF SAM domain-containing protein LOC100685327 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DEIDHEDETD;DETDSEDEKDSEDETDSEDDN;FFKLFRDMLCFVTVG;HEDETDSEDEKDSEDETDSE;HITESKDVLDAKESGFIKDF;IENDTLPLESGSERC;QDLTIIENDTLPLESG;SDGGSNNG;SEDETDSEDDN;VLDAKESGF 10 5.3 1.0021 -1.1343 0 8.29136 0 9.69559 0 5.99179 8.67515 5.39015 0 0 0 0 9.54942 0 0 A0A8C0NKU6 A0A8C0NKU6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;SLTNMDAKILNKILANRIQQY;SQSEKEKHYMFS 5 6 0.98494 -0.2464 0 0 0 0 4.88884 0 0 0 0 0 4.56395 0 0 0 0 A0A8C0NKV3 A0A8C0NKV3_CANLF Protein arginine methyltransferase 9 PRMT9 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] protein-arginine N-methyltransferase activity [GO:0016274] AMDTHCQNNEMSC;EQALELFPDDEVICNSMGE;LDNPIQVEMGEELV;LSLAPELKDDVKETFQYTLFRW;PELKDDVKETFQYTLFRW;PVELLRLDLMTPYL;SEAELCSALANLQTSK;VLDIGAGTGIL 8 12.9 0.97356 0.038635 11.0289 11.2473 0 0 0 0 0 9.31052 8.43446 0 0 7.67567 7.26228 6.11946 0 A0A8C0NKX6 A0A8C0NKX6_CANLF Neurofibromin 1 NF1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AKLKRLLKETAFKFKALKKV;DTLEKCLA;EALLVLHQL;ESPPQYQTSYLQS;ETDYEMETQ;FTKEEHMRPFNDF;GTASALDWWPKIDAVYCHSVEL;GVGCDVPSSGTTSQMSM;HGDPSYRTL;IHHGDPSYRTLKENQ;LDEEVLTDPKIQA;LFMNLLNDCSEVEDENAQTGG;LLVLHQLDSI;NMFSKEVELADSM;QELTVCSEDNVDVHD;TSPYPPAVQ;VEQTIAIMKNLLDNHTEG;VGQTSPRARKS;WNPDAPVETFW;WQHVSFEVDPTRLE 20 8.9 0.99908 -3.2334 0 0 11.4833 0 11.7053 0 11.0318 12.2105 12.3341 9.50993 5.87325 5.09841 9.83955 0 0 A0A8C0NKZ1 A0A8C0NKZ1_CANLF Mesothelin like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDFELHPPDLLL;LFLVRYDCLQ;LSEGGLDASRAN 3 5.1 1.0025 -1.1673 0 0 0 0 8.87077 0 10.3993 0 0 0 0 0 0 0 0 A0A8C0NKZ6 A0A8C0NKZ6_CANLF PNMA family member 6A Canis lupus familiaris (Dog) (Canis familiaris) IPEDCDEAE;VELDREVN;VSARRGLLILGIP 3 7.5 1.0029 -0.89457 8.14501 0 0 0 0 0 0 0 4.24016 0 0 0 0 3.82782 0 A0A8C0NL02 A0A8C0NL02_CANLF "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737] phosphatidylinositol phosphate phosphatase activity [GO:0052866] HNIHVMRESL;RMRPQVHRSS 2 3 0.99026 -0.26641 0 0 0 0 0 0 0 0 10.8215 0 0 0 0 0 0 A0A8C0NL06 A0A8C0NL06_CANLF SANT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] CASPETRVPGSAEV;NNIALKYKK;SPSPPPAG;TELTFRQHLNS 4 3.3 1.0004 -0.63296 10.5443 0 0 10.4011 10.7393 10.4997 10.0729 10.3653 0 0 0 0 0 0 9.70344 A0A8C0NL13 A0A8C0NL13_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KKKGSKRKIG;LVVIVIVVFVVYRQKKKGS;YISMKPNVS 3 4.9 1.002 -1.3663 4.11528 0 0 0 6.5611 0 0 0 0 0 0 9.66731 0 0 0 A0A8C0NL16 A0A8C0NL16_CANLF SFI1 centrin binding protein Canis lupus familiaris (Dog) (Canis familiaris) AAALVARGRRQL;GGGDQPPARRALRGGRP;LRRWHLKWAWRVWRRRVLQLRVA;RVWRRRVLQLRVAQRLQQQ;TLQQKQGQPP;VQAPAQEQGRGS;VQVHRQGLRRSVFQRWRRAAARRRR 7 7.3 0.97887 0.035538 0 0 0 0 4.7981 0 0 0 0 0 0 0 0 0 0 A0A8C0NL18 A0A8C0NL18_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] PRGALSEHIETQIRLRRPRRRRRP;TQIRLRRPRRRRRPPRSSL 2 9.6 0.93425 0.090712 0 0 7.01848 0 0 0 0 0 0 0 0 0 0 0 6.71301 A0A8C0NL31 A0A8C0NL31_CANLF Probable G-protein coupled receptor 173 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IVAFMAVLFCFH;PAISQNWTFHG;VLFCFHAAFMLFCIS;YAKRMTLWTCAA 4 14.9 0.98658 -0.41973 0 0 0 0 9.46932 8.3285 0 0 0 0 0 0 9.05376 0 0 A0A8C0NL39 A0A8C0NL39_CANLF "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747] QSDRIFHKFTQLPGRKYCPGYNAD;VIEDIEYLKYD 2 10.3 0.97343 0.041303 9.2247 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NL40 A0A8C0NL40_CANLF Filamin A Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin filament binding [GO:0051015] AEIVEGENHTY;AKHGGKAA;AVRDVDIIDHHDNTYTVK;LHSVDVTYDGSPV;LPTHDASKV;LVSAYGAGLEGGVTGSPA;NVGAGSHPN;PMAPGSYL;QQGPVGINVTYGGDPIP;VDVVENEDGTF;VGSHCDLSLKIPEIS;YTVTITWGG 12 6.1 0.98379 -0.24311 0 0 0 8.93307 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NL51 A0A8C0NL51_CANLF SMB domain-containing protein TINAG Canis lupus familiaris (Dog) (Canis familiaris) CYCDNFCERENSD;DDDCVTHFYEANALCYCDNFCEREN;YCDNFCERENSDCCPDYKS 3 16.8 0.86703 0.14451 0 6.22537 0 0 0 8.58466 0 0 0 0 6.27919 6.7849 0 0 0 A0A8C0NL57 A0A8C0NL57_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) LOC483905 Canis lupus familiaris (Dog) (Canis familiaris) peptidyl-prolyl cis-trans isomerase activity [GO:0003755] SEPLGQSSKTTENFHTLSTGEKG 1 15 0.93532 0.065914 0 7.0493 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NL65 A0A8C0NL65_CANLF Keratin 33A KRT33A Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ELLSLKQNHEQEVNILR;VGNCGWFC 2 6.2 0.98588 0.046227 0 0 0 0 0 0 0 7.48261 0 0 0 0 0 0 0 A0A8C0NL97 A0A8C0NL97_CANLF MAP7 domain containing 3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] DEADDEDESESDDGSSDD;EADDEDESESDDGS;EALLESMETSP;ESSPKPKVEAAPEA;LYPEAQEWICDKII;NTYEEDEADDEDESESD;TDHVEEKPGARPPYTSLRESN;YEEDEADDEDESESDDGS 8 10.2 0.72515 0.24865 8.67267 0 9.7262 11.6148 0 5.69541 0 0 10.5941 8.49725 5.759 0 0 6.22884 0 A0A8C0NLA6 A0A8C0NLA6_CANLF Interleukin-33 IL33 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; nucleus [GO:0005634]; transport vesicle [GO:0030133] cytokine activity [GO:0005125] DKALVKSPKLRKSQQKPEGV;EASTTKAKMK 2 10.7 0.99418 -0.56147 0 0 0 0 0 0 6.02048 0 0 6.99639 6.75942 0 0 0 0 A0A8C0NLA8 A0A8C0NLA8_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] EEDVRRLFQPFGHIE;GVADPLQQAYAGMHHY;GVNGFGPL;PASRRRRRRRRRRRRRPAPPP 4 8.7 1.0038 -1.0552 0 0 0 0 0 8.60555 0 0 7.77893 0 0 0 0 0 0 A0A8C0NLB6 A0A8C0NLB6_CANLF EFR3 homolog A EFR3A Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659] plasma membrane [GO:0005886] DELRATIWEPQHMDKIVPSLLFNM;EALKKAIDTSGMEEQEK;EAPYFLPEHIFRD;EDNVQKNYELL;FVKFANIEEDTPSYHRRYDFFVSRF;KDGCWLKCFPSGVCCCC;NTLLKHLRLSVEFEANDLQ;SFVKFANIEE;TIELANEE 9 15.8 0.98568 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 4.58346 0 0 A0A8C0NLC9 A0A8C0NLC9_CANLF Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) Canis lupus familiaris (Dog) (Canis familiaris) zeta DNA polymerase complex [GO:0016035] RCAGGAGS;VLVHTREAATR 2 3.1 1.0026 -1.4058 0 0 0 0 0 0 0 8.80858 0 0 0 0 0 0 0 A0A8C0NLD4 A0A8C0NLD4_CANLF SH3 and multiple ankyrin repeat domains 3 Canis lupus familiaris (Dog) (Canis familiaris) dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211] ionotropic glutamate receptor binding [GO:0035255]; synaptic receptor adaptor activity [GO:0030160] EKLPGSLRKG;EPKYIDRYQISRSNKNS;LQVEDAQERAALAV;PPPPPAPYYF;QRAPLPAA;SPTTVPGPASGK;TKRLFRHYTVGSYDSLTSHSDYVI;VEGLGAGA;VISELSSRLQQL 9 5.8 1.0021 -2.6236 0 0 9.49341 0 10.0987 0 9.54266 0 10.0787 0 7.74873 0 9.66103 11.2357 9.57873 A0A8C0NLE7 A0A8C0NLE7_CANLF MARVEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVFYLVHLFRLYRMLTCISWPLSIF;SGGGGGGA;SSSGGGGG 3 25.2 0.97861 0.035538 0 0 0 5.00414 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NLF9 A0A8C0NLF9_CANLF Bromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIEISLYTVEKKKKPSY;FLDSFFFP;IEWQSESSSSDSSSEYSDW;QKRRRPRYRKRL;RSSSSSLSSSRAPSPKGKQK;TIRRRLENRFYRRISALMWEVRYIE;VGIKYEVGPPTLCCLKLAFLD 7 7.6 0.98598 -0.25958 0 0 0 0 0 0 0 0 0 0 0 0 0 12.318 0 A0A8C0NLG6 A0A8C0NLG6_CANLF Neurotrypsin (Serine protease 12) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] KDAAVICRQLGYK;LVPDEFEEEIGVQQI;NLHEHKRVDS;REYRPDSSDYD;RLLHRRQKRIIGGK;VGDYHTLVPD 6 9.4 1.0033 -1.6194 10.3954 0 0 9.80033 0 0 10.7209 0 9.74494 0 0 0 0 0 0 A0A8C0NLH1 A0A8C0NLH1_CANLF Notch receptor 4 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; signaling receptor activity [GO:0038023] CEGRGGDGACDAGCSGP;DCSEDVDECE;DECLDRPCHPTGTAA;DGACDAGC;EEDINECASSPCANG;FTGQRCQTL;GVILLALGALLVLQLIRRR;GVILLALGALLVLQLIRRRRR;IEDNCTCHHGHCQRSSCVCDVG;LVLQLIRRRRR;PVAGVILLALGALLVLQLIRR;QAAMLTPPQESEMDVPD;QNGGSCQALLPALPGSPG;TCQCAPGFLGETCQFPD;TDHCASAPCLNGGTCV;VGPGPGPA;VPCAHGGT 17 9.8 0.96301 0.049233 0 0 0 0 0 0 0 6.1291 0 0 0 0 0 0 0 A0A8C0NLI3 A0A8C0NLI3_CANLF Calsequestrin Canis lupus familiaris (Dog) (Canis familiaris) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809] mitochondrial matrix [GO:0005759]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018] calcium ion binding [GO:0005509] ADSVWMEMDDEEDL;AGEINTEDDDEEEDDDDDD;DWLEDVLAGEINTEDDDEEEDDDDD;EFSADTLV;NTEDDDEEEDDDDD;PLALLLLLVLGPPRLGVQGEE;VLAGEINTEDDDEEEDDDDDD 7 17.2 0.97512 0.047166 0 0 0 0 0 0 7.84687 0 0 0 0 0 0 0 0 A0A8C0NLI5 A0A8C0NLI5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALGGGPRGRARRPL;GGGGGGGA;GGGGGGGG;GVQRCSRSRLLSSQRAARPAPP 4 6.8 0.92942 0.10759 0 0 0 6.21199 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NLI8 A0A8C0NLI8_CANLF Ankyrin repeat domain 13C Canis lupus familiaris (Dog) (Canis familiaris) ALGGAFPGGRTGGGK;LADFYLVNGLVLESRKRREHLS;VLDNEQKVYQRIHHEESEMETE 3 11.5 0.98689 -0.49959 0 0 0 5.61005 11.3571 0 0 0 0 0 0 0 0 0 0 A0A8C0NLI9 A0A8C0NLI9_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I [GO:0005747] LLFKRELRCNEGV 1 19.4 0.9454 0.061172 0 8.53461 0 0 0 0 0 0 7.99537 8.14873 0 0 0 0 0 A0A8C0NLJ7 A0A8C0NLJ7_CANLF Cytohesin 3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] guanyl-nucleotide exchange factor activity [GO:0005085] CFFWQRLKYEIAEVM;CTCACGSAHP;RKPNCFELYNP;THTFFNPDREGWLLK 4 11.2 0.94859 0.05391 0 0 9.21914 0 0 5.22269 0 0 0 0 0 0 0 0 0 A0A8C0NLJ8 A0A8C0NLJ8_CANLF Protection of telomeres 1 POT1 Canis lupus familiaris (Dog) (Canis familiaris) telomere maintenance [GO:0000723] "chromosome, telomeric region [GO:0000781]" single-stranded telomeric DNA binding [GO:0043047] FTLDDGTGVLE;HALQEVPHEGDMDIIL;IAVAGFAV;LTCMLFSGNYEAL;SEQEDSLRTL;SKYFNFTAEDQKMYFDLTCQ;VTSGTEQQIC 7 11.6 1.0031 -2.2915 0 0 10.791 0 9.87311 8.6743 0 0 10.6898 0 0 8.09334 0 0 0 A0A8C0NLN1 A0A8C0NLN1_CANLF Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) ADCY5 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] cilium [GO:0005929]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] DDDPPLGGDDPLA;LVMAVLCNRAAFHQDH;NPPHWGAERP;QDRFLLKQERLL;VLCNRAAFHQDHM 5 4.3 0.9467 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.32981 A0A8C0NLS3 A0A8C0NLS3_CANLF Protein archease Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] metal ion binding [GO:0046872] AFEQCAMAMFGYMTDTGTVEPL;YKFSADEFFIPREV 2 20.7 0.98972 -0.22035 9.2647 0 0 0 8.73156 0 0 0 0 0 0 0 0 0 0 A0A8C0NLS4 A0A8C0NLS4_CANLF Zinc finger protein 316 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" ADGEVEVEAREEAVAVGP;ATPRDEDLEDDEEEEEEEDE;CCPDCGQA;DEEEEEEEDEEEEEEEEEEDDDSLT;DFQRHRRGGGCAEAGSDG;DTVAAAGPEEAEAEAEAGPEGP;EEEEEEEEEDDDSLTAGSQGLVT;PGGGGGGG 8 11.6 1.0027 -1.3483 0 6.30983 0 0 0 11.2181 3.64466 0 9.19271 0 13.3133 7.02059 0 5.53593 0 A0A8C0NLU6 A0A8C0NLU6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ARRRRRRRKRPQMMKRRRSKRLTVW;EELERQQEALR;RRGAPIYKRRRRYGPKS;RTRRRRRRIRRRRRRQ 4 17.2 0.97942 0.035538 0 0 0 0 0 0 6.65464 0 0 0 0 0 0 0 4.50087 A0A8C0NLU8 A0A8C0NLU8_CANLF Small membrane A-kinase anchor protein C37H2orf88 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein kinase A regulatory subunit binding [GO:0034237] PPAPKIVI 1 8.4 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 0 4.82171 0 0 0 A0A8C0NLV9 A0A8C0NLV9_CANLF Matrin-type domain-containing protein SF3A3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DLYDDKDGLRKEELNAISGP;FSSWEELAS;RKHPNEICVPMSVEFEELLKAREN;RLMDVMAKEMLTKKSTLRDQIN;SEEAQNLV;SGNLRDLY;WPKETSSALTHAG 7 20.2 1.0032 -2.1466 4.95689 0 0 9.02448 0 0 11.2043 10.6694 3.95336 0 0 0 0 12.4 0 A0A8C0NLW0 A0A8C0NLW0_CANLF "phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66)" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity [GO:0016316]" IYYSPENTAKAKEVLSN;QHSPDSLK;SEKDRVWA 3 3.8 1.003 -2.1626 0 0 0 0 0 0 0 0 9.43738 0 0 0 8.84389 0 9.81876 A0A8C0NLX0 A0A8C0NLX0_CANLF hexokinase (EC 2.7.1.1) HKDC1 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] DFLDYMGLKGVQ;EPSEADCI;IVQCIADFLDYMGLK;KATDCEGEDVVDMLREAIKRR;NEIIRGNGSEL 5 6.3 1.0014 -0.64163 8.75425 0 8.42543 6.3051 9.25449 0 0 0 8.31569 8.35979 0 7.262 9.77288 7.88527 10.5278 A0A8C0NLX4 A0A8C0NLX4_CANLF SSX family member 2 interacting protein SSX2IP Canis lupus familiaris (Dog) (Canis familiaris) adherens junction [GO:0005912]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] PGSQEGCYSGCS;SKLTKSLPASPSTSDF;SQEGCYSGCSLTYTN;VGRADGKRG;VIAMGEWM;VLQQMKKE 6 8.6 1.0034 -2.2589 0 0 14.0809 0 0 5.15623 0 0 0 0 0 0 0 6.52508 0 A0A8C0NLY8 A0A8C0NLY8_CANLF Melatonin receptor type 1A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] melatonin receptor activity [GO:0008502] GCGHGPGG;GPAGATGAGYPPGL;GTGCGHGPG;ILVLQVRRRVK;RRVKPDSKPKMK;SPAGGCGGA 6 7.6 0.99913 -2.9252 10.2932 10.6484 0 4.80462 0 0 0 0 10.7662 4.75964 0 7.30049 0 0 5.21669 A0A8C0NLZ5 A0A8C0NLZ5_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KELNQQRR;KMSRHHSRFERDYRVGWDRREWSA;PEVAAQEEILS;VGGRQMVGMTQRSLVAVTCWNPQNN;VGWDRREWSA;WNPQNNKWYPLASLPFYDREFFSVV;YHMLPHARQE 7 10.5 1.0031 -1.3382 8.5002 0 0 0 8.60755 0 9.24838 10.9875 0 0 0 0 0 7.74604 10.8315 A0A8C0NM19 A0A8C0NM19_CANLF "Leucine, glutamate and lysine rich 1" LEKR1 Canis lupus familiaris (Dog) (Canis familiaris) EEKVCKYC;ERVMLAQTQLIQ;KEDSLMACQQIYK;KLELDIEKEKH;NWREKIEAELSKE;RRECEERFELTEALSQ;SLHWSIKTHRS 7 12.1 1.0022 -1.4552 0 0 0 0 0 4.61765 11.0685 9.6575 11.0183 0 0 0 0 0 0 A0A8C0NM27 A0A8C0NM27_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) EPM2A Canis lupus familiaris (Dog) (Canis familiaris) glucan metabolic process [GO:0044042] cytoplasm [GO:0005737]; nucleus [GO:0005634] carbohydrate phosphatase activity [GO:0019203]; protein tyrosine phosphatase activity [GO:0004725]; starch binding [GO:2001070] EVELAPGE;GAVRLRPAGSA;RKVQYFLMAKRPAVYIDE;TIKLKHELGI;TNEMKHTTDFYFNI 5 18.9 0.99133 0.0031523 0 0 0 8.98228 10.3199 7.84172 0 0 9.19296 0 0 0 8.895 0 0 A0A8C0NM34 A0A8C0NM34_CANLF Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) BHMT Canis lupus familiaris (Dog) (Canis familiaris) methionine biosynthetic process [GO:0009086]; methylation [GO:0032259] cytosol [GO:0005829]; nucleus [GO:0005634] S-methyltransferase activity [GO:0008172]; zinc ion binding [GO:0008270] PLKFSSCNVPIF;RGNYVAEKISGQKV 2 6.4 0.99243 -0.16692 11.4422 0 0 0 0 0 0 0 5.70016 0 0 0 0 0 8.39648 A0A8C0NM42 A0A8C0NM42_CANLF [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) KDM4C Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] GLFTQYNIQKKAMTVKEFRQLA;PRLTEAREANP;RHCPAIMEVAEVE 3 4.2 0.99127 -0.1449 7.14619 0 0 0 0 0 0 0 0 8.21461 0 0 0 6.54382 0 A0A8C0NM43 A0A8C0NM43_CANLF CARD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] TTLPRPGDPGAPPLPPELQLE 1 9.5 0.9502 0.04991 0 0 0 0 0 0 0 7.41988 0 0 0 0 0 0 0 A0A8C0NM44 A0A8C0NM44_CANLF Leucine rich repeat containing 1 LRRC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] GGGGGDVP;IGKLKKLSI;LDVAGNRLLHLPLSLTALKLKAL 3 7.2 0.99661 -0.57643 0 0 13.0315 0 0 0 0 0 0 13.0999 13.2367 13.2627 13.4459 7.34811 13.6337 A0A8C0NM58 A0A8C0NM58_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] membrane [GO:0016020] pyridoxal phosphate binding [GO:0030170] GLLLLLLLLLLLPLLLTL;GLLLLLLLLLLLPLLLTLL;GLLLLLLLLLLLPLLLTLLL;GRRPRGLLLLLLLLLLLPLLLT;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLP;LLLLLLLLP;LLLLLLLP;LLLLLLPL;LLLLLLPLLLTLLL;LLLLLPLL;LLLLLPLLLTLLLPLLLLLP;LLLPLLLLL;PGGRRPRGLLLLLLLLLLL;PLLLTLLLPLLLL;PLLLTLLLPLLLLLPLL;RGLLLLLL;RGLLLLLLLLLLLPLLLT;RGLLLLLLLLLLLPLLLTL;RGLLLLLLLLLLLPLLLTLLL;RRPRGLLLLLLLLLLL;SLHNRLRFL 25 8.5 0.64831 0.33752 8.69683 4.71716 5.88792 0 0 4.70504 8.00955 7.70093 0 0 7.65664 0 8.64757 7.17353 5.43979 A0A8C0NM59 A0A8C0NM59_CANLF Pantothenate kinase 1 PANK1 Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] GGGGGGGG;LHTTLCATGG;PGPGGREAALGVARPGERGE;VGGGGGGG;VGGGGGGGG;VNGLLHNGFHPP 6 11.1 0.99654 -0.58349 0 0 0 8.64122 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NM72 A0A8C0NM72_CANLF Adenine DNA glycosylase (EC 3.2.2.31) Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]" ETQPEWSYLS;LEQLLDSNL;NWYDREKRDLP;TLQDLAGASLEE 4 5.8 1.0016 -0.75232 0 0 0 0 7.05572 0 0 0 0 0 0 0 0 0 0 A0A8C0NM75 A0A8C0NM75_CANLF dolichyl-diphosphooligosaccharide--protein glycotransferase (EC 2.4.99.18) STT3B Canis lupus familiaris (Dog) (Canis familiaris) post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279] membrane [GO:0016020] dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872] FKKGKKISKKTV;KTTKRKRGYIKNKL;LASHGFYE;RKRGYIKNKLVFKK 4 4.8 0.98625 -0.45379 9.38007 9.28965 0 0 2.82587 0 0 5.49908 0 0 0 0 0 0 0 A0A8C0NM80 A0A8C0NM80_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EEEGWEYGTFG;EQETLSFLQLEEE;ERHAKQKGLPP;KVVIGGYQHNTR;KVYDCELEAVP;SLDPTVIKFPARLIIQIWDN;YHYVPWYNSKPV 7 4.8 0.93768 0.069563 0 0 0 0 0 0 0 0 0 0 0 8.92044 0 0 9.56602 A0A8C0NM84 A0A8C0NM84_CANLF Ring finger and CHY zinc finger domain containing 1 RCHY1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EGETRFLQ;FKVKEVQCINCEKIQ;NVSRQNCPICLEDI;VLPCGHLLHRTCYEEMLKE 4 22 0.98733 -0.4629 0 8.50989 0 0 0 0 0 0 0 0 0 0 0 0 9.52744 A0A8C0NM96 A0A8C0NM96_CANLF Calpain catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] AGKSPIFHFFEDPEGKIELPP;DETTIISQPDISQ;DLQTAHYPI;IFLTGPPS;QFLEISSPFLNYRMTPF;VDLTQYIRTV;VISLHPGYVDKVWELLK;VLSIRDIDQEEQFKVKD 8 7.6 1.0025 -1.1639 0 0 10.5285 0 0 8.99127 9.63014 0 13.8068 0 0 0 0 0 9.67967 A0A8C0NME8 A0A8C0NME8_CANLF NADP-retinol dehydrogenase (EC 1.1.1.300) RDH10 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811]; membrane [GO:0016020] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" HIVTVASS;MYIVTFMKSI 2 5.9 1.0029 -1.7158 0 7.56613 0 0 0 0 7.98362 0 0 7.58774 0 7.69697 0 0 11.1838 A0A8C0NMF4 A0A8C0NMF4_CANLF Septin SEPTIN6 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] EELKIGNKMMKARQY;KDTDPDSKPFSLQETYEAKRNEFL;LKSLDLVTM 3 11.8 0.951 0.053874 0 0 0 0 3.98422 0 5.18106 0 0 0 0 0 0 0 0 A0A8C0NMH6 A0A8C0NMH6_CANLF BTB domain-containing protein KLHL2 Canis lupus familiaris (Dog) (Canis familiaris) AVIAWVNH;SPHPPGTSAVTL;TTNTWRQVADMNMCRRNAGV 3 6.4 0.98939 -0.51955 0 6.40671 0 0 0 0 0 0 7.70591 0 0 0 0 0 0 A0A8C0NMI1 A0A8C0NMI1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PWVPFAHVS 1 4.8 1.0044 -0.80421 0 0 0 8.89248 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NMK0 A0A8C0NMK0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PDGFPREFYQTFK 4 6.2 0.99051 -0.26743 0 0 0 0 0 0 0 0 0 0 0 0 0 9.03637 0 A0A8C0NMM2 A0A8C0NMM2_CANLF RNA helicase (EC 3.6.4.13) DDX21 DDX50 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of transcription by RNA polymerase III [GO:0045945]; R-loop processing [GO:0062176]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; transcription by RNA polymerase II [GO:0006366] B-WICH complex [GO:0110016]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] 7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515] GVCFDVPTAA;LDSVPPTA;SPKAKKVK 3 3.3 1 -2.8202 8.38612 0 10.0262 0 0 0 0 0 0 0 8.69725 9.72554 0 9.23072 8.90923 A0A8C0NMM8 A0A8C0NMM8_CANLF Fucosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] fucosyltransferase activity [GO:0008417] DDFPSASSLAAH;DRNPAVYRRYFHWRRSYAVHITSFW;VGVLLWWE 3 11.5 0.98741 -0.47846 0 0 0 0 9.73011 0 7.72397 12.8216 0 0 0 0 0 0 0 A0A8C0NMN7 A0A8C0NMN7_CANLF Unk like zinc finger Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] AEQQFHPEIYKSTKCNDM;DEHDSGDP;GQLCGGDGVPDLQ;PDVYCSKYDEASGVCPDGDE;SSTASSGQPAHN 5 6.8 0.94624 0.05044 0 0 7.36343 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NMQ6 A0A8C0NMQ6_CANLF Ankyrin repeat and sterile alpha motif domain-containing protein 1B ANKS1B Canis lupus familiaris (Dog) (Canis familiaris) ephrin receptor signaling pathway [GO:0048013] cytosol [GO:0005829] ephrin receptor binding [GO:0046875] EVEEEDDDENTC;IHHGPSHS;RTPSFTSEWEEI;TLANLPWIV;VEEEDDDENTC;YPKKRNYTMEIV 6 4.1 1.0019 -1.2091 0 7.07436 5.49563 9.50022 0 0 0 7.715 0 0 0 0 10.1315 0 0 A0A8C0NMT4 A0A8C0NMT4_CANLF B30.2/SPRY domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RPPAVRGSRDRFTGE 1 4.8 0.95121 0.053898 0 0 0 0 8.6299 0 0 0 0 0 0 0 0 0 0 A0A8C0NMT9 A0A8C0NMT9_CANLF Bile acid-CoA:amino acid N-acyltransferase Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637] thiolester hydrolase activity [GO:0016790] HLFIHWGGEVT;SSLHLFIHWGGEVT 2 3.6 0.98505 -0.24064 0 0 0 0 0 0 7.71781 0 0 0 0 0 0 0 0 A0A8C0NMV6 A0A8C0NMV6_CANLF Choline O-acetyltransferase (EC 2.3.1.6) Canis lupus familiaris (Dog) (Canis familiaris) acyltransferase activity [GO:0016746] GAPGGLGETLQQKLLE;LVKDSTNRDALDMI 2 5.5 0.9924 -0.18066 0 0 0 0 7.44593 0 0 0 0 0 0 10.5452 0 0 0 A0A8C0NMV8 A0A8C0NMV8_CANLF Integrin subunit alpha 7 ITGA7 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] VGEQLGHHIHGQEGTAPGRMLFE;VILLAVLAGLLVLALLVL;VLLMWKCGFFHRSSQ 3 5 0.99252 -0.19401 0 0 0 6.17131 0 0 0 0 0 0 0 0 11.2521 0 0 A0A8C0NMV9 A0A8C0NMV9_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] APPTWVRASP;GVTDGNREQK;LARRHTAP;RSRRPPAPSAAAFSAQARSAAEPG 4 5.2 0.99729 -0.59677 0 0 0 0 0 0 10.9368 0 9.77559 0 0 0 0 0 8.97791 A0A8C0NMX9 A0A8C0NMX9_CANLF Protein kinase domain-containing protein SCYL2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LGPVFKQQE;LQKSQFFKGLP;QAQKLKSQQPLK;RGGSCTLV 4 4.5 1.0009 -0.62532 10.2725 9.83627 0 0 0 7.37955 0 10.079 0 0 0 0 0 0 0 A0A8C0NMZ1 A0A8C0NMZ1_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AKYEWLMK;DEDDHRNS;GVTLYPYQISQ;IAANPTAL;ISTLGKAMVTIS;LESRVNFCKAHLMMIT;VAEVIQSVVNGA;VPALQKARGD 8 4.7 0.99671 -4.2811 10.2289 0 7.74295 0 0 0 0 0 8.9188 10.043 10.8425 0 0 0 0 A0A8C0NMZ7 A0A8C0NMZ7_CANLF Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] EVMHGTGD;VNDTVGTMMTCGYDDQNCE 2 3.2 1.0038 -1.055 8.13489 0 0 0 0 0 0 6.58531 0 0 0 0 0 0 0 A0A8C0NN01 A0A8C0NN01_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PKIPGGGG 1 8.6 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.49418 A0A8C0NN05 A0A8C0NN05_CANLF Sema domain-containing protein SEMA4F Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] GAQLSVLEDL 1 1.7 0.98994 -0.26397 0 0 0 0 0 0 0 0 0 0 0 7.52364 0 0 0 A0A8C0NN08 A0A8C0NN08_CANLF Leucine-rich repeat-containing protein 37 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) QPMQETPTQ 1 1.4 1.004 -0.80421 8.39566 0 0 4.99968 0 0 0 0 0 4.56016 0 0 0 0 3.59252 A0A8C0NN11 A0A8C0NN11_CANLF "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3" SPOCK3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] DDDDDGDDHDGYI;DDDDGDDHDG;DDEDDEDDIMKDEDEIEDD;DDEDEGDDDDDGDDHDG;DEDEIEDDDEDEGDDDDDGD;DEGDDDDDGDDHD;DEIEDDDEDEGDDDDD;DEIEDDDEDEGDDDDDGD;DEIEDDDEDEGDDDDDGDDH;DEIEDDDEDEGDDDDDGDDHDG;EDDDEDEGDDDDDGDDH;EDDDEDEGDDDDDGDDHD;EDEGDDDDDGDDH;EDEIEDDDEDEGDDDDDGDD;EIEDDDEDEGDDDDDGDDH;GAAGAGGG;GAGAGGRCEGRQVR;GAGGAPAAL;GDDDDDGDDHDG;GDDDDDGDDHDGY;GPSRRVKR;KDEDEIEDDDEDEGDDDDD;LPICKDSLGWMFNRLDTNYDLLL;MKDEDEIEDDDEDEGDDDD;RGGGCGPG;RGWQVWTGSR;RHRHRHRHRRRHRRSRSRARRRPS;SDGHTYSS;TVSQYDREGGQWNR 29 16.4 0.99672 -4.331 0 7.21374 7.7987 8.07885 10.0373 5.56337 10.5768 10.3402 11.4983 7.35535 4.60928 10.5174 0 13.2436 5.92258 A0A8C0NN49 A0A8C0NN49_CANLF Connector enhancer of kinase suppressor of Ras 1 CNKSR1 Canis lupus familiaris (Dog) (Canis familiaris) AGATLVLKKV;DLTSNPRPGPS;LSSDPREQ;SKYQSSRR;WRRCWFVLKRHTLYWY 5 7.5 1.0031 -2.128 0 0 0 0 0 0 0 8.02719 10.8114 0 0 9.30652 0 0 0 A0A8C0NN93 A0A8C0NN93_CANLF LRR binding FLII interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020] AEKLDQEDND;EKGSRSLPGLSAAT;ELVDEIPGPG;LVCACVFICITM;PEKDFTEKGSRSLPGLS;REDPAQECVDTE 6 7.5 1.0025 -1.1841 0 0 0 0 9.12903 5.68125 10.3674 0 0 11.2691 7.81967 0 8.1103 0 0 A0A8C0NN95 A0A8C0NN95_CANLF Anoctamin ANO5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] AAKMTFIIVMEHV;AIYPMVLNWWRRRKARTNSEKLY;EDEGAGPGETVGPGE;KPSEPPNPV;LFYEYLET;LMTIKILHDFEL;PAETFPFSYMLGP;SEDEGAGPGETVGPG;SEECDPGG 9 8.7 0.9909 -0.20961 0 0 0 0 0 0 0 0 0 0 0 7.1472 0 0 11.5978 A0A8C0NNB9 A0A8C0NNB9_CANLF Phospholipase A2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543] AAIECLARSSINSS;ADDTRVMPQFAEM;AKCVGRSLCAQLLCAC;AKLSIDVNCVSK;FCLTSRCPEEFESYGCYCGQE;SINSSLNHLDT 6 17.3 0.99235 -0.040617 0 0 0 0 10.4333 0 0 10.3025 7.54589 7.6732 0 0 0 6.37502 0 A0A8C0NND0 A0A8C0NND0_CANLF Rho GTPase activating protein 45 ARHGAP45 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] DAAATEATGSPE;EAAAQTPHPEASAG;FQGAECEECCLAC;GDGDGDGD;KLRDYVLRD;RIVEVEQDNKMTPG;RMALDMDFVKGL 7 7.5 1.0027 -1.1981 0 0 9.38787 0 9.09424 0 0 0 0 5.7795 9.41853 0 0 9.49135 0 A0A8C0NND2 A0A8C0NND2_CANLF Delta-like protein JAG1 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] DGAKWDDDCNTCQC;ECECSPGWTGPTCSTNA;EGYSGPNCEIAEHAC;TNDCSPHPCYNSGTCVDGD;VGECRSSSLQPVKTKCT;YYCDCLPGWTGQNCDI 6 8.3 0.98747 -0.33469 10.0978 0 12.5539 0 0 5.37309 0 0 11.1455 6.16159 0 14.2333 0 0 0 A0A8C0NND6 A0A8C0NND6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LPAYPGATSTFPPPP 1 1.5 0.95199 0.053901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.195 A0A8C0NND7 A0A8C0NND7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EEGKGGVAPLEEERAG 1 1.5 0.96198 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.21534 A0A8C0NNF5 A0A8C0NNF5_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLFKTPREAE 1 4.9 0.9883 -0.26449 0 0 0 0 0 0 9.63074 0 0 0 0 0 0 0 0 A0A8C0NNF7 A0A8C0NNF7_CANLF Carboxypeptidase (EC 3.4.16.-) CTSA Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type carboxypeptidase activity [GO:0004185] LLLLLLLL;LLLLLLLLL;LLRLLLLLLLLLWAPPG;LWAPPGQAAPDLDEIQ;RLLLLLLL;RLLLLLLLL;SPPWLLRLLLLLLLL;WLLRLLLLLLL;YDNTDPECVTNL 9 8.9 0.97548 0.045316 0 0 0 0 9.35553 0 2.72472 10.8919 0 0 3.92001 7.09961 0 0 0 A0A8C0NNI1 A0A8C0NNI1_CANLF THAP domain-containing protein 11 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DLTVQVEFAAAEGAAA;EDVKPIDLTVQVEFAAAEGAAA;TLQAAVDSSQAP 3 12.1 0.85161 0.15797 0 7.00562 9.59255 8.81794 0 0 0 0 0 0 0 0 0 0 6.32744 A0A8C0NNJ8 A0A8C0NNJ8_CANLF FAT atypical cadherin 1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AILPLEIFIT;DIQIVSLQPSE;EAGNELDLFSLNPNSGVLSLK;FIEIYIEVE;GLITTTSRKLDREQQDEHILE;IIVEDINDNP;IVSGNDDGAFEVN;LCRAVFICIQSV;LFAEYAANV;LKIEARDQAREE;LSTSETLD;NGGTCFDSLDGAVCQCDSG;QFRATKYEVDIGSNAPKGTSV;QVRATDSDSEPNRGISYHM;TATEDCSSSPCQNGG;TYSIISGNEHGKF;VPVGSSVM 17 5.7 0.98405 -0.25511 0 0 0 0 9.49333 0 0 0 0 0 0 0 0 0 0 A0A8C0NNK1 A0A8C0NNK1_CANLF Telomere length regulation protein TEL2 homolog TELO2 Canis lupus familiaris (Dog) (Canis familiaris) ARRGPDAGPNEFSLVAGWFFF;FPLLGEELLRVLQAVVDSLRDGW;QPRPRTACRTGPRRPCRIS;RQRMDILDV;SRFQEPYSEHHGIRS 5 8.7 0.98735 -0.35349 10.9584 0 0 0 4.27806 10.5218 12.3212 0 12.1233 0 4.1534 4.18737 0 0 0 A0A8C0NNK5 A0A8C0NNK5_CANLF Nuclear receptor coactivator NCOA1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983] AQMLAQRQR;DLDQFDQLLPTLE;NISDIDSLSVKPDKC;RQLIQQQRAMLMR;SETLPASLQ;SSPSYRFILNDGTMLSAHTKCKLCY;VLSERFPPQQATPPLM 7 7.2 0.98864 -0.3083 7.93204 9.55344 0 0 0 0 0 0 0 0 0 0 0 9.01942 6.40069 A0A8C0NNL4 A0A8C0NNL4_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; regulation of immune system process [GO:0002682] extracellular space [GO:0005615] KEQEADTALG;RGIRLLASIIRLLASPQISGKWFY;TDDTILLREYL 3 14.1 0.99218 -0.20731 0 0 0 0 0 0 9.63746 0 0 7.50875 0 8.10008 0 7.96688 0 A0A8C0NNL6 A0A8C0NNL6_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LYALLQLHFCGPNVI;SILGMTESCFLAAMGYDRC;SWSVDLITLIKMESY 3 15.4 0.99388 -0.15203 0 0 0 0 0 10.4792 13.4624 0 0 0 0 0 0 0 7.71637 A0A8C0NNN3 A0A8C0NNN3_CANLF NGFI-A binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] transcription coregulator activity [GO:0003712] LLHPPLLLLRPLLLPLPPP;VTNPGLFNQPLTSLPVS 2 3.3 0.92662 0.095637 0 0 0 0 0 0 5.918 9.07066 0 0 0 0 0 0 0 A0A8C0NNP8 A0A8C0NNP8_CANLF Voltage-dependent anion-selective channel protein 3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] LDTIFVPN;QTLQPGIKLTLS 2 7 0.94487 0.05044 0 0 0 0 0 0 0 0 0 0 7.8996 0 0 0 0 A0A8C0NNP9 A0A8C0NNP9_CANLF FBA domain-containing protein FBXO44 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AGVATACSG;GAAGGRPGADK;GRDRGSSTRPPQVIFLR;RGPRLLKARARAPAPP;VATACSGVRS 5 9.4 1.0021 -1.2287 17.0535 0 0 0 0 0 10.0363 0 0 5.38256 0 0 8.29632 0 0 A0A8C0NNR1 A0A8C0NNR1_CANLF tRNA:m(4)X modification enzyme TRM13 (EC 2.1.1.225) TRMT13 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050] ERLQIDIQHLCL;GNEKNVPEKWT;PISSLSEEQLESL 3 7.5 0.86265 0.16052 0 0 0 0 0 0 0 8.04838 6.73159 3.93471 0 0 0 10.5239 0 A0A8C0NNS2 A0A8C0NNS2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MRQFNDPTTLQNAYKEKWCIYLV;NDPTTLQN 2 25.8 1.003 -0.7817 0 0 0 0 0 0 0 11.5128 0 0 0 0 0 0 0 A0A8C0NNT2 A0A8C0NNT2_CANLF Neutral sphingomyelinase activation associated factor NSMAF Canis lupus familiaris (Dog) (Canis familiaris) KEHNIVAPYKIE;KNFILPIG;LVWDLLGG;VGALNKERLERLL 4 3.7 1.0032 -2.0988 0 0 10.9595 0 0 0 0 0 6.86691 0 0 0 4.02936 7.79902 0 A0A8C0NNV2 A0A8C0NNV2_CANLF CD1a6 molecule CD1A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLVVIVPLVLLAGLAWCLWKR;RPHSMGLVFLVVIVPLVLLAGLA;VNLRIHSHISDFC 3 12.4 0.9513 0.059561 0 0 0 0 0 5.70194 0 0 0 0 0 0 0 0 0 A0A8C0NNV4 A0A8C0NNV4_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] ACEDGYRLENETCMSC;CMSCPFGLGG;FDLADGMQKCVN;GDDCSVDV;HTESTTSRGS;IHVDGTSP;RHSCIFPGQYNPSFI 7 5.6 1.0031 -2.1263 0 9.5207 6.57162 9.74562 0 0 0 11.7506 0 9.30738 0 8.80555 0 0 0 A0A8C0NNX4 A0A8C0NNX4_CANLF Angiomotin like 1 AMOTL1 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] identical protein binding [GO:0042802] AQPAGKVL;EHQVDNTVMEKQG;FKAGGGPSPAQPAGK;PLHSVSLPLPLPMTLAAP;SPEELGPPPVCYSPG;WEQKYLEESTIRHF 6 7.8 0.98395 -0.24382 0 8.48708 6.90352 0 13.6039 0 6.48277 0 0 0 5.88906 0 6.68636 9.73195 0 A0A8C0NNY7 A0A8C0NNY7_CANLF Acyl-coenzyme A oxidase ACOXL Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949] AAWAFYPAPLQP;DKLRTRRRRRRRRTNKA;IEHQTQTLRLMP 3 6 0.99249 -0.19265 0 7.56201 0 0 0 0 0 0 3.40694 0 0 0 0 0 0 A0A8C0NNZ1 A0A8C0NNZ1_CANLF Carbonic anhydrase (EC 4.2.1.1) Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] WNSVKYQNYKEAIM 1 4.5 0.94286 0.061104 0 0 0 0 0 0 0 0 0 0 7.31506 0 0 0 0 A0A8C0NNZ7 A0A8C0NNZ7_CANLF BTB domain-containing protein RCBTB1 Canis lupus familiaris (Dog) (Canis familiaris) ACGQTSSMAVLDN;AEGQKHTALTWYQDTRYR;FLQYLYTDAVDLPP;TDDVFACFATPAV;VGSGSTTN 5 13 1.0029 -1.5839 0 0 0 0 0 0 9.58978 6.65864 0 0 10.107 0 0 0 0 A0A8C0NP06 A0A8C0NP06_CANLF F-box protein 6 FBXO44 FBXO6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GVITSCPH 1 2.5 0.98964 -0.26527 8.296 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NP40 A0A8C0NP40_CANLF Transmembrane protein 192 TMEM192 Canis lupus familiaris (Dog) (Canis familiaris) late endosome [GO:0005770]; lysosomal membrane [GO:0005765] LEDIVEKQGDVI;SFPAPARLYLYLVLAILALELL;VILAFLTVIILGKVILWILH 3 20.1 0.99417 -0.16146 0 0 0 0 0 0 0 0 10.7228 0 0 0 0 9.4781 0 A0A8C0NP43 A0A8C0NP43_CANLF Kallikrein B1 KLKB1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; serine-type endopeptidase activity [GO:0004252]" CTFHPRCL;EGEELNVTFAEGVN;FEGEELNVTFAEGVN;FSLKSCALSEIGCHM;GNWHLVGITSWGEGCGRREQ;ILEKTQVGDGHAGLG;LGSYPEVQKQVDS;MYTPNAHHCQMMCTF;SSIKVLADVVSGFSL;VEYRNSCLLKNGPG;YPEVQKQVDSE 11 11.5 1.0019 -1.3109 8.92297 0 0 0 11.7108 6.15791 0 0 0 10.4916 11.267 6.03999 11.091 9.39832 0 A0A8C0NP55 A0A8C0NP55_CANLF Small integral membrane protein 10 like 1 SMIM10L1 Canis lupus familiaris (Dog) (Canis familiaris) ELAWQLRMNFPYFYV;WQLRMNFPYFYVAG 2 25 0.9925 -0.17789 6.25318 5.52428 10.703 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NP58 A0A8C0NP58_CANLF Solute carrier family 25 member 43 SLC25A43 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020]; mitochondrion [GO:0005739] LLCAGAAG;LLKKERRKKKKERK 2 6.9 0.93849 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 4.99422 0 A0A8C0NP60 A0A8C0NP60_CANLF Solute carrier organic anion transporter family member SLCO2B1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] ATFLPKFLERQFS;ESLQEHGEPAHEGV;MLRLYVDIDRMPEGG;PELFPACSEPCSCPLDDFNP;VGIMFMAQTLLGVGSVPIQPFGIS;VIHGSAID 6 12.8 0.93545 0.073895 0 0 0 0 0 12.6961 0 0 0 0 0 13.3099 0 0 0 A0A8C0NP68 A0A8C0NP68_CANLF SEC7 domain-containing protein IQSEC1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DGDNDSINSTSNSN;ELKTNEDHVSQVQKVEKLI;LFENQYYPNGIRLTS;RDKSEGESSRSVRSSLE;RENAGLLERHRRHLAAC;SCRSTPSLERQ 6 7.6 0.99564 -0.086319 0 0 0 12.2797 0 0 0 0 0 0 0 0 0 10.0066 0 A0A8C0NP72 A0A8C0NP72_CANLF Bromodomain PHD finger transcription factor Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] NURF complex [GO:0016589] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AEETQDSEDDEEDEMEEDDDDSD;CCETCSAVYHLE;CDYQDGLDTLPSTKES;DAEETQDSEDDEEDEMEEDDDD;DDEEDEMEEDDDD;DDEEDEMEEDDDDSD;DEEDEMEEDDDD;DEEDEMEEDDDDS;DEEDEMEEDDDDSDY;DEEDEMEEDDDDSDYPEEMEDDDD;DIDIVKSPEEIEKDKNETE;DSDYPEEMEDDDDD;DSEDDEEDEMEEDDDDSDYP;DSEDDEEDEMEEDDDDSDYPE;EAHLRQQRLAVQQKRLEQQ;EDDDDDASYCTE;EDDDDSDY;EDDDDSDYPEEMEDDDDD;EDDEEDEMEEDD;EDDEEDEMEEDDD;EDDEEDEMEEDDDDSDYPEE;EDEMEEDDDDSD;EDEMEEDDDDSDYPEEMEDDD;EEDDDDSDYPEEMEDD;EEDDDDSDYPEEMEDDDDDASY;EMEDDDDDASYCTE;ETQDSEDDEEDEMEED;GGRGGGGG;GPADLKDSVNSTLYF;GPVIIETWVAEEEL;IDGMTWPEV;IREVPYFNYNAKPA;NENRESEKK;PNTSGSGG;PQSPAQPEVQT;RTETSETEITTTEII;SEDDEEDEME;SEDDEEDEMEEDDDD;SKLSQLKSQ;SLPSVPKST;TQDSEDDEEDEMEE;TQDSEDDEEDEMEEDDDD 42 6.7 0.99088 -0.2691 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.59831 A0A8C0NP73 A0A8C0NP73_CANLF Macrophage-expressed gene 1 protein (Perforin-2) Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] phagocytic vesicle membrane [GO:0030670] NLRNVDMGRVMDLTY;VLEVLPGG;VLNYGTHVVTSVD 3 5.2 1.0026 -1.1283 0 10.473 0 0 0 0 0 0 10.9034 0 0 0 0 0 0 A0A8C0NPA8 A0A8C0NPA8_CANLF Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) TMED10 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; transport vesicle membrane [GO:0030658] GVEAKNYEEKKNKEGE;KGKFAFTTEDYDMFEVCFE;RRLEDLSESIVNDFAYM 3 22.3 0.86245 0.14501 6.30606 0 0 0 0 5.67095 0 0 0 0 0 0 0 0 9.06248 A0A8C0NPB3 A0A8C0NPB3_CANLF Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex assembly [GO:0033108] mitochondrial intermembrane space [GO:0005758] DENNYDRERC;YFLKYKNCRKWN 2 26.2 0.99447 -0.56102 0 9.11621 0 0 0 0 0 0 0 0 0 0 4.97874 0 0 A0A8C0NPC1 A0A8C0NPC1_CANLF Catsper channel auxiliary subunit epsilon CATSPERE Canis lupus familiaris (Dog) (Canis familiaris) CatSper complex [GO:0036128] DTEQWVYQDFA;ELLWNANEP;FLKFVKIITTKKLKNLL;IFSTRSTIKLE;NYSFCNLTTVFA;VLSYFHYM;VLSYFHYMRIYKQQI;YLRNQTSKNLRVKYNWK 8 9.7 1.002 -1.83 0 0 0 0 10.177 10.9298 10.2523 0 10.3425 7.89736 0 0 0 0 4.41095 A0A8C0NPD3 A0A8C0NPD3_CANLF Choline transporter-like protein SLC44A2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] organic cation transmembrane transporter activity [GO:0015101] CVFLLLAIVGYVA;DEPRLSPDGKQ;EVIIILLLIFLRKR;EVIIILLLIFLRKRIL;IIILLLIFLRK;IIILLLIFLRKRILI;IILLLIFLRKRILIA;LLIFLRKRILIAIALIKEA;LLLIFLRKRILIAI;LSILEVIIILLLIFLRKRILI;PPRPAPAGSGLPLEAACG;SILEVIIILLLIFLRKRILIAI;VIAMLMSLLFIVLLRFLAG;VIIILLLIFLRKRILIAI 14 11.9 0.58605 0.37427 6.35885 7.8387 0 6.33185 7.82972 0 8.96139 8.83384 9.30816 0 0 0 0 7.84887 0 A0A8C0NPG3 A0A8C0NPG3_CANLF Actin-related protein 3 (Actin-like protein 3) ACTR3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] AGRDITYFIQQLL;IDVGYERFLGPEI;PSLLLARCCLGFPAPP 3 7.3 0.95142 0.053741 0 0 0 0 0 0 0 11.3812 0 0 0 0 0 0 0 A0A8C0NPH4 A0A8C0NPH4_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096] EALKQVAEKLPRPNLLLLKHLISVL;HLLAAIFK;SLEHTDSSDLSM;TESWEQSRTVHASAETIGQVTVTRR 4 9.9 0.98623 -0.39037 0 0 4.79571 0 0 0 0 9.82404 0 0 0 0 0 0 0 A0A8C0NPK2 A0A8C0NPK2_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 3 ADAMTS3 Canis lupus familiaris (Dog) (Canis familiaris) collagen biosynthetic process [GO:0032964]; extracellular matrix organization [GO:0030198]; in utero embryonic development [GO:0001701]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; vascular endothelial growth factor production [GO:0010573] extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CGDETAMGSV;DQQLREAARHRRHTGENDYNIEVLL;GVCGGDNS;GVEWDYNIEDDIET;LSLWLIAAALVEVRTSADG;LVSPATKSGPLNSSSE;NWGSWTKFGSCSRTCGTG;PCPSQWKTGPWSECSVTCGEG;PIRRMCNIQECTHPLWVA;VSTNFEGHYL 10 13.2 1.0028 -1.9018 0 10.3557 0 0 8.51503 0 0 9.18745 0 11.418 15.7902 13.3604 6.64847 0 9.04715 A0A8C0NPK4 A0A8C0NPK4_CANLF Anti-proliferative protein domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GPKAGAKP;SALPKGKPSD;TLDHTSGI 3 10.8 1.0028 -0.8697 0 0 0 0 0 0 0 7.64832 0 0 0 0 0 0 9.1213 A0A8C0NPL1 A0A8C0NPL1_CANLF Transporter Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] plasma membrane [GO:0005886] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine:sodium symporter activity [GO:0005369] FTSPVTEFWERNVLSLSSGI;LFDYYAASGV;VGAGAGAG 3 4.4 0.98795 -0.48596 0 0 0 0 10.0968 0 0 0 9.95939 0 0 9.40254 0 8.76477 0 A0A8C0NPM5 A0A8C0NPM5_CANLF Leucine rich repeat containing 8 VRAC subunit D LRRC8D LOC119872273 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] FTDVAEIPAWVYLLKNLR;LHVKSNLTKVPSN 2 3.6 0.98809 -0.22432 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.0605 A0A8C0NPN4 A0A8C0NPN4_CANLF KIAA0319 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CITLDGSKSIDDQ;KRRKRTKIRKKTKYTIL;PAAGDVIDGSDHSATLQLTNLV;PAPRQPNGSAWI;SGEEGLMLSYDPLARLEFSPAS 5 8.7 0.9864 -0.41754 0 0 0 0 0 8.19495 9.72627 0 11.1364 0 0 0 6.00329 0 0 A0A8C0NPN8 A0A8C0NPN8_CANLF "RAB22A, member RAS onco family" RAB22A Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; phagocytic vesicle membrane [GO:0030670] GTP binding [GO:0005525]; GTPase activity [GO:0003924] SGGKGFKL;VEVMERDAKD 2 9.9 1.0021 -1.3628 0 0 0 0 0 0 0 0 0 0 0 0 9.273 0 0 A0A8C0NPQ5 A0A8C0NPQ5_CANLF Major facilitator superfamily domain containing 13A LOC489976 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPWFPWKYY;VWSPFSIRNK;YHMNRFEPKRSLE 3 7 0.99067 -0.53793 0 0 0 0 0 0 9.00048 0 0 0 0 0 0 0 0 A0A8C0NPR5 A0A8C0NPR5_CANLF Keratin 23 (Keratin 27) KRT23 KRT28 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] DTWYKEQAAAMA;GSRKGNSLPGASGKEV 2 6.7 0.98816 -0.49201 0 0 0 0 9.35731 0 0 0 0 0 0 0 0 0 8.71229 A0A8C0NPS8 A0A8C0NPS8_CANLF Geminin DNA replication inhibitor GMNN Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA replication [GO:0006275] nucleus [GO:0005634] RKALYEALKENEKLHKEIEQK;SENKNFFEI 2 14.3 0.98899 -0.26503 0 0 0 0 0 0 0 0 0 0 0 7.58984 0 0 0 A0A8C0NPS9 A0A8C0NPS9_CANLF Exportin-2 (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) Canis lupus familiaris (Dog) (Canis familiaris) protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; nuclear envelope [GO:0005635] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] ALITDLHSSF;EDNMETWMNNF;LVRGLCKFFEGPV;PEFFEDNMETWMNNFHTL 4 4.6 1.0033 -0.89139 0 0 0 0 0 0 0 0 9.03114 0 0 0 0 0 0 A0A8C0NPV4 A0A8C0NPV4_CANLF Keratin-associated protein 9-3-like Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CRPSYCGQSCCRPA;CSTSGNCGSSCCQPSCCQTSCCQP;QPTSCQTSCCQPTCCQTSCCQPSCG;SGNCGSSCCQPSCCQTSCCQPT;SSCCQPSCCQTSCCQ;STSGNCGSSCCQPSCCQTSCCQPT;TSCQTSCC;TSCQTSCCQPTCCQ;TSGNCGSSCCQPSCC;YCSYCCPPTCCQ 10 48.3 0.95397 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 3.97737 0 A0A8C0NPW2 A0A8C0NPW2_CANLF Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) EIF2S1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic stress granule [GO:0010494]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] GGGGGHTPG;LSRRRIRSINKL;RRLTPQAVKIRAD 3 10.6 0.99387 -0.16194 8.12102 0 8.37539 0 0 0 0 6.10589 0 0 0 0 0 0 0 A0A8C0NPX3 A0A8C0NPX3_CANLF Taspase 1 TASP1 Canis lupus familiaris (Dog) (Canis familiaris) threonine-type endopeptidase activity [GO:0004298] GARRELGRCSDENKIP;VGKTCGRWMRS 2 5.8 0.99728 -0.10602 0 0 11.7071 0 0 16.7128 0 0 0 0 0 0 0 0 0 A0A8C0NPX9 A0A8C0NPX9_CANLF Protein disulfide-isomerase (EC 5.3.4.1) PDIA3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to interleukin-7 [GO:0098761]; extrinsic apoptotic signaling pathway [GO:0097191]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; platelet aggregation [GO:0070527]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238] cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; melanosome [GO:0042470]; Tapasin-ERp57 complex [GO:0061779] identical protein binding [GO:0042802]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] DYEKNAKG;EKAKKKKKAQ 2 3.6 1.0027 -1.1226 0 0 0 0 0 0 0 0 0 0 0 0 0 5.87278 0 A0A8C0NQ16 A0A8C0NQ16_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MDAFLESHKL;MNEKGEITTNT;SEVSQSVKDKHY;TVRRFLKQLK;WAKDMNRNFTEEDIDMANMH 5 5.7 1.0029 -0.87035 0 0 0 0 2.90856 0 0 8.26299 0 0 0 0 0 0 0 A0A8C0NQ19 A0A8C0NQ19_CANLF "Abhydrolase domain containing 3, phospholipase" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] LDWFDNYNSKCY;REFDKRFTSVM;VGWNTFACSESLEKPL 3 11 0.99025 -0.20181 0 0 0 0 7.22342 0 0 0 0 0 0 0 0 9.79554 0 A0A8C0NQ20 A0A8C0NQ20_CANLF Phosphoinositide-3-kinase regulatory subunit 2 PIK3R2 Canis lupus familiaris (Dog) (Canis familiaris) insulin receptor signaling pathway [GO:0008286]; intracellular glucose homeostasis [GO:0001678]; negative regulation of MAPK cascade [GO:0043409]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin filament polymerization [GO:0030833]; regulation of autophagy [GO:0010506]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976] "focal adhesion [GO:0005925]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]" phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein heterodimerization activity [GO:0046982]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971] ALYPFRRERPEDLE;IFEEQGQTQEKCSKEYLERF;KLRDTPDGTFLVRDASSKIQGEYT;PGLTLPDLPEQFSPP;VLHYQHASLVQ 5 11.6 0.99357 -0.16196 10.6704 10.9324 0 8.57796 0 11.0331 5.07506 11.6096 0 0 0 0 11.0603 10.9383 0 A0A8C0NQ30 A0A8C0NQ30_CANLF Dynamin-binding protein (Scaffold protein Tuba) DNMBP Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556] anchoring junction [GO:0070161]; Golgi stack [GO:0005795]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085] DEFWLLGK;DLDMCSPAPEEPNL;DPDSSPQPRSW;EFYESNIESL;GVPEPGWFEGELEGRR;LDMCSPAP;PGAEPEAI;TGQFPSSFVEIVTIPSL;TQIPNIDFEG;VEIVTIPS 10 6.2 0.99681 -4.6552 0 7.56217 11.0217 0 0 0 9.96022 7.4417 10.9432 7.51475 7.45236 6.77241 0 0 0 A0A8C0NQ43 A0A8C0NQ43_CANLF RRM domain-containing protein RBM33 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GELDDLQVAPETEEGSM;LSGGQGGE;NSGGGDGP;QEQEDCVAEGELDDLQ;QKDIKEESDEEDDDDEES;YLQACGQQGLQEQEDCVAEG 6 5.8 1.0046 -2.0092 7.9693 13.3008 0 13.5292 0 0 0 15.2732 15.3196 0 12.0117 14.6655 5.18349 0 2.98634 A0A8C0NQ45 A0A8C0NQ45_CANLF "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7)" ACADM Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] mitochondrial matrix [GO:0005759] flavin adenine dinucleotide binding [GO:0050660]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991] AEYDKTGEYPVPL;MGQRCSDTRGIVFEDVK;TEPGAGSD;VEADTPGVQ;VFEDVKVPKE 5 13.2 0.99384 -0.12069 0 9.66811 10.1649 0 9.67634 0 0 0 0 0 0 0 0 0 0 A0A8C0NQ53 A0A8C0NQ53_CANLF Spondin-like TSP1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CKKPKKPQRRQNNRLKPLT;EWSEWSPCS;GAQEGCGP;GPRRGVLQLLPLLLLLLLLLL;GVLQLLPLLLLL;GVLQLLPLLLLLL;GVLQLLPLLLLLLLLL;GVLQLLPLLLLLLLLLL;GVLQLLPLLLLLLLLLLLLR;HYDYNVTD;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLPLLLLLLLLLLLLR;LQLLPLLLLLLLLLLLLR;PLLLLLLLLL;QLLPLLLLLLLLLLL;QVCQSSPCEDEESMY;RGVLQLLPLLLLLLLLLLL;VLQLLPLLLLLLLLLL;VLQLLPLLLLLLLLLLLL;VLQLLPLLLLLLLLLLLLRP 24 5.1 1.0031 -2.2623 7.11468 0 7.71225 0 6.63509 5.86042 6.73349 2.81566 5.81522 0 2.41373 4.96481 0 9.75642 4.38695 A0A8C0NQ56 A0A8C0NQ56_CANLF SPRY domain containing 7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLPQEGDVVLM 1 6.6 0.99089 -0.19613 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4609 0 A0A8C0NQ57 A0A8C0NQ57_CANLF Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; P-body assembly [GO:0033962] nuclear speck [GO:0016607]; P-body [GO:0000932]; PML body [GO:0016605] RNA binding [GO:0003723] HRRLLHQRQQQNRN;IEKTYSLLLDV;PVLQPQPGSL;VGQVLPPA 4 6.5 1.0031 -1.9565 0 0 3.9137 10.1431 6.0594 5.87485 0 0 0 0 5.91593 0 0 5.72039 6.47302 A0A8C0NQ64 A0A8C0NQ64_CANLF dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) TMTC3 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] AVVSVIFLKVCKLFLD;GYFNLGMLAMDDKKDSEAEV;ILMQESGEVKLRPEARKRLLSY;RHLNIVRDKIS 4 8.1 0.98752 -0.40377 0 0 0 0 9.08058 0 0 11.0988 0 0 0 0 10.302 0 0 A0A8C0NQ74 A0A8C0NQ74_CANLF "Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)" SYT8 Canis lupus familiaris (Dog) (Canis familiaris) troponin complex [GO:0005861] actin binding [GO:0003779] ESEKQNYLSE;GWGLGAGE;VGDWRKNIEEKSGM 3 6.6 1.003 -1.1044 0 0 0 0 0 10.0904 0 0 0 0 0 0 0 0 0 A0A8C0NQ81 A0A8C0NQ81_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] PAAPPALRCGDLLHCALS;PVPCMIPFVP 2 6 0.98432 -0.25692 0 0 0 0 0 0 0 10.0349 0 0 0 0 0 0 5.86953 A0A8C0NQ88 A0A8C0NQ88_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AGTARLFDP;LVHVPNHAGLSCNRTRTR;SVIDHTHVPEFEVA 3 13.3 1.0019 -1.2839 0 0 0 0 0 0 0 0 11.3243 0 6.87897 0 0 0 0 A0A8C0NQ91 A0A8C0NQ91_CANLF Double C2 domain beta DOC2B Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] membrane [GO:0016020]; synapse [GO:0045202] metal ion binding [GO:0046872] AKPPEDEPDADGYESDDCTA;ETLTYYGI;GPIRPIKQ;GVVLGINAKG 4 11.1 1.003 -2.4255 0 5.38933 0 0 8.16012 0 10.1473 0 0 0 0 0 0 0 0 A0A8C0NQA5 A0A8C0NQA5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCPSCCLR;CCISSCCRPSCCGSSSCGSSCCR;CQGSCESSSCGPQCCQ;CRPSCCGSSSCGSSCC;GSSCCRPSCCCPSCCLRPV;ISSCCRPSCCGSSSCGS;LVTCQGSCESSSCGPQCCQP;PSCSMNSCAQPVCCEA;PVCCEATICEPSCSVSSCC;SCCGSSSCGSSCCRPSCCCPSCC;SCCRPSCCGSSSCGSSCCRPSCC 11 31.4 0.94111 0.070682 7.11666 6.04376 0 7.3805 4.33735 6.16064 0 0 8.78362 8.99554 0 0 3.22129 0 7.95611 A0A8C0NQA6 A0A8C0NQA6_CANLF SAM-dependent MTase RsmB/NOP-type domain-containing protein NSUN3 Canis lupus familiaris (Dog) (Canis familiaris) RNA methylation [GO:0001510] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] FIPQPLVDVIK;IKEMARTC;VGVRTGAGVGPPARGILLLAV 3 9 1.0022 -1.2019 0 0 0 0 0 4.14763 9.9405 0 0 0 8.91133 0 0 0 0 A0A8C0NQA8 A0A8C0NQA8_CANLF Mitogen-activated protein kinase 8 interacting protein 3 MAPK8IP3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] MAP-kinase scaffold activity [GO:0005078] AVRWTEMIRASREHPSVQEK;DVSSYLCTELDK;EKALRKQAEEKFIEFEDA;FIEFEDALEQEKKELQ;GPSLSPANKTSPTSGEGARP;PSEEDSGNG;VLMERNQYK 7 7.2 1.0034 -1.9625 0 0 7.79325 6.52091 8.83933 12.7527 8.22843 8.70172 0 0 0 7.58143 0 0 0 A0A8C0NQB6 A0A8C0NQB6_CANLF Kalirin RhoGEF kinase KALRN Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] cytoplasm [GO:0005737]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DAEKMFDWIS;DLELAIHHH;DNKTVLKASNIETKQEW;ELRLSLEEFFN;EVFLKYIHRNNVSMPS;LFHERKIKLDIFLQLRIF;VGKSLHRA;VGKSLHRARAL;VRLHQRLQLCVF;WRIAPRGIS 10 6.7 1.0047 -0.80421 0 0 0 0 0 0 0 0 8.84787 0 0 0 0 0 0 A0A8C0NQE0 A0A8C0NQE0_CANLF Immunoglobulin superfamily member 9 IGSF9 Canis lupus familiaris (Dog) (Canis familiaris) DENYEWDSEFP;NYEWDSEFPGDME;PVTRVLLKAPPAFLER;QVLEVQELEP;SYLSPAPGDTSS;VPVGAAYL 6 5.4 1.0024 -0.7272 0 0 4.17145 10.2502 0 6.86802 0 0 9.90585 0 0 0 0 0 0 A0A8C0NQF7 A0A8C0NQF7_CANLF Tripartite motif containing 4 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] RGDMEAEDLQEDLTCSICLD 1 3.2 0.94763 0.050235 0 0 0 0 0 0 5.50322 0 0 0 0 0 0 0 0 A0A8C0NQG9 A0A8C0NQG9_CANLF Large ribosomal subunit protein uL30 (60S ribosomal protein L7) Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" cytoplasm [GO:0005737] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] HYHKEYRQMYRTDIRMARMARKA;KLAFVIRIRGINGVSP;NGVSPKVRKVLQLLRLRQIF;PAEPKLAFVIRIRGING 4 23 0.85655 0.18994 6.87049 0 4.22257 0 0 0 0 8.63902 5.28559 0 0 0 0 0 0 A0A8C0NQH1 A0A8C0NQH1_CANLF "Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal)" DNALI1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ADLPLGGSTDPGKGL;VSPQQPGPSGPV 2 8.7 0.98246 -0.25105 0 0 0 0 0 0 0 0 0 0 8.28193 0 10.1246 0 9.85946 A0A8C0NQK5 A0A8C0NQK5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SPWGPASPV 1 5.1 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 0 6.70694 0 0 0 A0A8C0NQL2 A0A8C0NQL2_CANLF Nucleoplasmin core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; single fertilization [GO:0007338] nucleus [GO:0005634] EEEEDPEEEEEEEEESH;LKDQSPVKKAKPTLKPKKP;TAVLWDCELNQ 3 22.7 0.98079 0.035491 0 0 0 0 0 0 0 0 0 9.38444 0 0 0 0 0 A0A8C0NQM7 A0A8C0NQM7_CANLF Methylenetetrahydrofolate reductase (EC 1.5.1.53) MTHFR Canis lupus familiaris (Dog) (Canis familiaris) methionine metabolic process [GO:0006555]; tetrahydrofolate interconversion [GO:0035999] methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489] AADLVRHIRS;DPIVGWGPSGGYVFQKAYLEFFTS;FEADLKYLKEKV;FMFWKDEEPRGPRQLSRCLVPAS;PATALCSKATPAPVW;PLPWAVSAHP;VGALLQVLKKYELRVNY;VGFSVPPSI;VGWGPSGG;VNYHIVDVKGENIT 10 19.2 0.99904 -3.1898 0 10.4439 11.4335 9.95262 0 10.4706 0 0 0 0 4.32279 11.1678 0 0 9.39609 A0A8C0NQQ0 A0A8C0NQQ0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) EEENYVESSK;KQEMRQKTTFP;KYSDSSPK;LDSESFIHLLEPYLQQH;SSDCECSNC 5 8 1.0006 -2.7739 9.19572 3.67016 0 0 0 0 0 6.87049 0 0 0 0 0 0 7.51562 A0A8C0NQQ1 A0A8C0NQQ1_CANLF Homeobox protein HOXC9 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; proximal/distal pattern formation [GO:0009954] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VPDCSDFPSCS 1 4.2 0.98059 0.035491 0 0 0 4.04544 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NQQ3 A0A8C0NQQ3_CANLF Angiotensin II receptor associated protein AGTRAP Canis lupus familiaris (Dog) (Canis familiaris) angiotensin-activated signaling pathway [GO:0038166]; regulation of blood pressure [GO:0008217] plasma membrane [GO:0005886] GGLAATVF 1 5 0.98946 -0.2632 0 0 0 0 0 0 0 0 0 0 0 0 9.88705 0 0 A0A8C0NQT1 A0A8C0NQT1_CANLF Transmembrane protein 131 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSPIINIHNPHS;GFCGAGGS;HHVHSPLEQ;INCQEFALSANASK;IRFEPPMLDFHEQPVGMPK;LFINTSNHGV;LKRTFKVENTG;PFTTPASTLPSI;PRHLKFPL;SPPLEVFTEQP;VGMPKMEKVYL;YSISLYRGNCRP 12 7.4 0.93689 0.072535 0 0 15.0604 0 0 0 14.6342 14.4829 0 0 0 0 0 0 0 A0A8C0NQW2 A0A8C0NQW2_CANLF Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (Mediator complex subunit 27) MED27 Canis lupus familiaris (Dog) (Canis familiaris) mediator complex [GO:0016592] VLPPQYVDDVISRIDR;VSHLDDHS;WSNKLQYHAGLASGL 3 12.9 1.0018 -0.96299 10.1292 0 0 9.37667 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NQW6 A0A8C0NQW6_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP11B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AKVIRLIKISP;CLDSMCCFSEGE;FYFLIIFLVQL;LREHEKLFME;LSSDRLDG;LYVTVEMQKFLGSF;MSVIVQAPSGEKLLF;SYFLIGKDISLLGNGQ;TAIKQGYEDWLRHNSDNEVNGAP 9 10.4 0.94379 0.05044 0 0 0 0 0 0 0 0 3.14872 0 0 0 0 0 0 A0A8C0NQX2 A0A8C0NQX2_CANLF 2'-5'-oligoadenylate synthetase 1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LLKPLFSR;RLHLYRQLYLCH 2 5.8 1.0027 -0.79052 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3576 A0A8C0NQY3 A0A8C0NQY3_CANLF Microtubule associated protein 1A Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule [GO:0005874] microtubule binding [GO:0008017] AAPPSTVSGHREL;DEVLQQDKTLEQKDIFVEQKDT;EDKGFKSPPC;EPTPYPDERSFQYADIYEQM;GVGKEDATEQIVKPG;LSKPCCYI;NRDPGIQAFLTVSCLGE;PEVSPEDTQSL;PGARPPEDPAEPLCE;PGGASGGQ;PLNGNILSCSPDRRTPS;PPEEEDKLTRSPFEIISP;PSAESISSEL;PTSASDSGSSQSDSDV;QESPVQEDKTMKPKEKVLEEKSP;SASDSGSSQSDSDVPPETEECPSI;TAEAALDSDEDGDF;VGLPPEEEDKLTRSPF;VLPDRTEAREES;WDDSTSDSELEKGAREQ 20 9.2 0.9975 -3.3977 0 10.2859 12.1667 10.7142 0 9.89406 9.78934 10.2038 11.8741 0 8.70884 0 0 11.3792 10.0433 A0A8C0NQY5 A0A8C0NQY5_CANLF Double-strand break repair protein MRE11 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; meiotic cell cycle [GO:0051321] "chromosome, telomeric region [GO:0000781]; Mre11 complex [GO:0030870]" 3'-5'-DNA exonuclease activity [GO:0008296]; DNA endonuclease activity [GO:0004520]; manganese ion binding [GO:0030145] DEDDDDDPF;EELVKYQLEKTQ;EEVRRFRESRQK;GVDFESDEDDDDD;GVDFESDEDDDDDPFMN;GVDFESDEDDDDDPFMNIN;LDEILRLAQENEV;NPKVTQAIQSFC 8 10 1.0018 -1.2113 0 6.6744 0 0 0 0 6.19539 10.8514 0 0 3.80725 0 0 5.43062 4.21101 A0A8C0NQY6 A0A8C0NQY6_CANLF Ezrin (Cytovillin) (Villin-2) (p81) EZR Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; microvillus membrane [GO:0031528]; ruffle membrane [GO:0032587] actin binding [GO:0003779] LERQAADQIKSQE 1 2.4 0.99241 -0.16547 0 0 0 0 0 0 0 11.0787 0 0 0 0 0 0 0 A0A8C0NQY8 A0A8C0NQY8_CANLF ATP synthase lipid-binding protein (ATPase protein 9) (ATPase subunit c) LOC100682717 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] SLIPSRSFRTSAIS 1 10 0.98891 0.035305 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85426 A0A8C0NR13 A0A8C0NR13_CANLF Fe2OG dioxygenase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" MEEGTNRTVEPRA;VGKHFVNLY 2 7 0.9914 -0.5454 0 0 0 0 0 0 0 0 0 0 8.54859 0 0 0 0 A0A8C0NR23 A0A8C0NR23_CANLF AT-rich interactive domain-containing protein 3 (ARID domain-containing protein) Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677] APGKGGGG;EDEDEEEE;EDEEDEDEEEEEEDYEDE;EEEDYEDEEVLGPL;EQFKQLYE;GKGGGGRG;LDLFMLYVLVTEKGGL;TSAAFTLRTQYMKYLYPYECEKRGL;WEEEEEEEELEEDLEED 9 16.4 0.97922 0.048313 0 0 0 0 3.96781 0 0 0 0 0 0 0 0 0 0 A0A8C0NR28 A0A8C0NR28_CANLF 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidic acid biosynthetic process [GO:0006654] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] GVWTVLLLLLLLLLLLL;GVWTVLLLLLLLLLLLLPA;GVWTVLLLLLLLLLLLLPAL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLP;LLLLLLLLLLLPA;LLLLLLLLLLLPAL;LLLLLLLLLLPAL;LLLLLLLLP;LLLLLLLP;TVLLLLLLLLLL;TVLLLLLLLLLLL;TVLLLLLLLLLLLLP;VLLLLLLLL;VLLLLLLLLLL;VLLLLLLLLLLL;VLLLLLLLLLLLL;VLLLLLLLLLLLLPAL;VLLLLLLLLLLLLPALWF;YVVVSNHQ 24 10.6 0.98957 0.015474 7.32948 0 9.4494 5.92298 3.7822 3.13175 4.85534 0 7.98362 5.31208 0 0 0 4.33935 0 A0A8C0NR29 A0A8C0NR29_CANLF Argonaute linker 1 domain-containing protein AGO3 Canis lupus familiaris (Dog) (Canis familiaris) miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] AMWKMMLNIDERDL 1 6.1 0.94139 0.061003 0 9.43133 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NR39 A0A8C0NR39_CANLF Calmodulin-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calmodulin binding [GO:0005516]; small conductance calcium-activated potassium channel activity [GO:0016286] ASSARGSRALQVSAG;EIQLFMVDNGADD;ELHAQHEELEAR;LSTVILLGLVILYHAREI;QEEEEDDE;VLYDLMSELHAQHEEL;VLYDLMSELHAQHEELEA 7 11.3 0.98803 -0.49569 0 0 0 8.68008 0 0 0 10.2702 0 4.67587 0 0 0 0 0 A0A8C0NR40 A0A8C0NR40_CANLF Inversin INVS Canis lupus familiaris (Dog) (Canis familiaris) protein localization to ciliary inversin compartment [GO:1904108]; Wnt signaling pathway [GO:0016055] ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DQFGRTPL;EVVHAGPNALQHRTPRNKTTQD;FMKLLLTRRANWM;MAVLMENNADPNIQDKEGR;SQRTALHL;TDPAPGPL 6 7.7 1 -2.8269 0 10.0532 9.68242 0 0 0 0 11.2048 7.04581 2.51629 0 0 0 0 0 A0A8C0NR87 A0A8C0NR87_CANLF Ankyrin repeat and LEM domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519] EAAPGHSPELAEALRTGCIPD;LLMDPRETQ 2 6.1 0.94741 0.054578 0 0 0 0 0 0 0 0 0 0 7.36361 0 0 0 0 A0A8C0NR97 A0A8C0NR97_CANLF Reelin RELN Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; neuron migration [GO:0001764] extracellular region [GO:0005576] hydrolase activity [GO:0016787]; lipoprotein particle receptor binding [GO:0070325]; metal ion binding [GO:0046872] AYCVPVVP;KDDFEGQLESDRFL;KKDKTHNALSSR;LMLLDTFDFG;LYFGGSTVRQAITQDLDLR;QHERSPADAGP;SASTRLRWWQPSEN;SLCSTEHHPSSAYYPGTTQGWR;SVQASQSIGG;VMGGMCDPGDSHENDIS;VWIAPPAGTGCVNFMATATHRGQ;YHASEFMQWRRVI;YNNGKKEEIWI 13 5.3 1.0006 -2.7852 12.8467 0 9.99873 7.18368 0 11.029 0 11.9342 0 9.83529 10.6597 0 11.2079 12.5208 9.53008 A0A8C0NRA9 A0A8C0NRA9_CANLF Solute carrier family 15 member 4 Canis lupus familiaris (Dog) (Canis familiaris) dipeptide import across plasma membrane [GO:0140206]; histidine transport [GO:0015817]; peptide transport [GO:0015833]; protein transport [GO:0015031] membrane [GO:0016020] dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; symporter activity [GO:0015293] AVLILLLIPLKDKLV;GGGGGRGGPHAGSPTR;LILLLIPLK;VLILLLIPLK 4 4.2 1.0035 -1.635 6.87197 0 0 0 0 6.22653 0 0 0 0 0 6.95942 6.7385 0 3.1569 A0A8C0NRB1 A0A8C0NRB1_CANLF Ubiquitin-like domain-containing protein MIDN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] APVSSPCRPVS;DQQMDCSPPASSGASPTSTPGGSPT;GLPPPDQQMDCSP;KVERLQLLLQQKRLRRKARRDARG;LLHKDTRLSSGKLQEF;LLLQQKRLRRKARR 6 15.8 0.99321 -0.062561 0 11.1228 4.3659 10.2689 0 0 0 6.38374 0 0 0 0 5.68173 0 4.9231 A0A8C0NRB4 A0A8C0NRB4_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EIRFNGKGKKIRKPRTI;EWYVMMFSL;HESAHGSL;TDQQKTTVIENGE 4 12.3 1.003 -2.1118 6.58182 0 0 0 0 0 0 0 7.46818 0 7.64667 0 8.89866 3.909 0 A0A8C0NRB8 A0A8C0NRB8_CANLF HSac2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LYPNPYHRPF;VTESTLYP;WNNEKERILLVTDKTLWICKYDFI 3 14 1.0031 -1.7043 0 0 0 0 0 0 0 0 0 0 5.54794 0 0 0 10.2186 A0A8C0NRB9 A0A8C0NRB9_CANLF Extended synaptotagmin 1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] lipid binding [GO:0008289] AARQLLDDEERLT;EEAFRFFLQDPRSQE;HVLEAQDLIA;HVLEAQDLIAKD;IEVEVFDKDPDK;LTAVLNTGFLD;TATSGHGGV;VHLRLEWLSLLPHA;VIVTSIPGQEL 9 8 1.0033 -2.2601 0 9.64214 15.1894 10.6542 11.3711 11.2486 0 10.6034 0 0 0 0 8.57338 9.1005 0 A0A8C0NRC4 A0A8C0NRC4_CANLF Adenylyl cyclase-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cAMP-mediated signaling [GO:0019933]; cell morphogenesis [GO:0000902] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin binding [GO:0003779]; adenylate cyclase binding [GO:0008179] GVGGYGSQAWAL;PGPPTAVP;TASKAGAA 3 8.3 0.98932 -0.52034 8.97318 0 0 0 0 0 0 0 0 0 0 0 10.127 0 0 A0A8C0NRD2 A0A8C0NRD2_CANLF DNA replication licensing factor MCM6 (EC 3.6.4.12) MCM6 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697] RDEVAEKCQKLFLDFLEEFQN;TEGSESYE 2 3.8 0.98775 -0.46406 0 0 0 0 8.47585 0 0 0 0 0 0 0 0 9.60002 0 A0A8C0NRE1 A0A8C0NRE1_CANLF Thioredoxin domain-containing protein PDIA5 Canis lupus familiaris (Dog) (Canis familiaris) protein disulfide isomerase activity [GO:0003756] EKPLLMMFYAPWCSMCKRIMPHFQK;LKKLLRTRNNVLV 2 7.6 0.98417 -0.24377 0 0 0 0 0 0 0 0 3.91829 0 0 0 0 0 7.00506 A0A8C0NRF9 A0A8C0NRF9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCDCKPTCCGSSC;CCGSSGCGSSCCQPCCC;CCQPCCCLPTCCHTTCCRTTCCKP;CCVSSCCQPSCCGSSG;CGSSCCQPCCCLPTCCHTTCC;CQPSCCGSSGCGSSCCQPCCCRP;CVSSCCQPSCCGSSGCGSSC;CVSSCCQPSCCGSSGCGSSCCQPCC;ESCCSPCCQPTCC;GCGSSCCQPCCCRPTC;GSSCCQPCCCLPTCCHTTCC;KPTCCVSSCCQPSCCGSSG;PSCCGSSGCGSSCCQPCC;PSCCGSSGCGSSCCQPCCCRP;SCCGSSGCGSSCCQ;SCCGSSGCGSSCCQPCCCRP;SCCQPSCCGSSGCGSSCCQPCCCL;SCCQPSCCGSSGCGSSCCQPCCCR;SESCCSPCCQPTCCKTTCYR;SSCCQPCCCLPTCCH;SSCCQPCCCRPTCCHT;SSCCQPCCCRPTCCHTTCCRT;SSCCQPSCCGSSGCGSSCCQPC;SSCCQPSCCGSSGCGSSCCQPCC;SSGCGSSC;TCCGSSCC;TTCYRTTCCDCKPTCCGSSCC;VSSCCQPSCCGSSGCGSSCCQPCCC 28 76.4 0.85153 0.14998 0 7.36964 0 6.30201 7.5499 0 6.76341 0 4.09626 0 5.12875 0 0 7.55098 5.32553 A0A8C0NRG0 A0A8C0NRG0_CANLF Prostate androgen-regulated mucin-like protein 1 Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; plasma membrane [GO:0005886] RHSSYGRLLDDQDYGSWGNY;SPVTSPLTTFP;SSPPSSPPSPPTAPVT 3 9.1 0.98697 -0.4082 0 0 0 0 0 0 0 0 0 0 0 0 8.91477 8.28063 0 A0A8C0NRH5 A0A8C0NRH5_CANLF Nucleolar protein 11 Canis lupus familiaris (Dog) (Canis familiaris) maturation of SSU-rRNA [GO:0030490] nucleolus [GO:0005730] RNA binding [GO:0003723] HDNKVLRIWSNEDVN;IYKSLIPIHPN;KSLIPIHPN;VIQRFTASVDRKVISL;YKSLIPIHPN 5 6.1 0.9865 -0.41978 10.4816 10.7864 0 0 0 5.46712 0 10.6201 0 7.64667 7.71569 7.18547 11.094 11.062 11.1688 A0A8C0NRI8 A0A8C0NRI8_CANLF Glycogen debranching enzyme (EC 2.4.1.25) (EC 3.2.1.33) (Glycogen debrancher) AGL Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980] cytoplasm [GO:0005737] "4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]" ARYNCRDAVWWWL;KESGYNMIHFTPLQTLGLSRSCYSL;LFTAEKAWKALE;MKDEGFNITAGVD;NDLGHPFC;VDEDIVAVTRHSP 6 5.7 1.0031 -1.4986 0 0 0 0 8.45142 9.72465 0 0 10.0661 11.1928 8.20823 0 0 0 0 A0A8C0NRK4 A0A8C0NRK4_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] VRTWIGNRRRKYRLM 1 2.4 0.95084 0.053889 0 0 0 0 0 0 0 0 0 0 0 5.39087 0 0 0 A0A8C0NRM7 A0A8C0NRM7_CANLF Tetratricopeptide repeat domain 13 Canis lupus familiaris (Dog) (Canis familiaris) AGCCCCYC;AGCCCCYCCYC;AGCCCCYCCYCCWG;AGCCCCYCCYCCWGG;AGCCCCYCCYCCWGGA;AGCCCCYCCYCCWGGAV;APAGCCCCYCCY;APAGCCCCYCCYCCWG;APAGCCCCYCCYCCWGG;CCCCYCCYCCWGGAV;CCCCYCCYCCWGGAVA;CCCCYCCYCCWGGAVAAA;CCCCYCCYCCWGGAVAAAD;CCCYCCYCCWGGAV;CCCYCCYCCWGGAVA;CCYCCYCCW;CCYCCYCCWGG;ELICVADRLGSLM;GCCCCYCCY;GCCCCYCCYCCW;GCCCCYCCYCCWGG;MAPAGCCCCYCCYCC;MAPAGCCCCYCCYCCWG;MAPAGCCCCYCCYCCWGGA;PAGCCCCYCCYC;PAGCCCCYCCYCC;PAGCCCCYCCYCCW;PAGCCCCYCCYCCWG;PAGCCCCYCCYCCWGGA 29 4.8 1.003 -2.4948 4.98928 7.34926 7.89118 6.21696 7.89869 0 10.0287 6.6595 7.7922 6.60196 0 3.91025 7.12928 9.84101 10.9588 A0A8C0NRP0 A0A8C0NRP0_CANLF G-protein coupled receptors family 1 profile domain-containing protein OR51S1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSVSDVGLATALMP;RLQPRKVG 2 6.9 1.0028 -0.7226 0 0 0 0 0 0 0 13.0486 0 0 0 0 0 0 0 A0A8C0NRP6 A0A8C0NRP6_CANLF Nuclear envelope integral membrane protein 2 NEMP2 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637] ISVNRNLVD;LCYPLKAFSYMRWRLRTWPRAERRA;LVSRLRAPGRFAEFVL;MRWRLRTWPRA;SVYFVYRFTEDLKWLWDENRIYIL;TSDSDCYCYNRN 6 22.9 1.0026 -0.7782 0 0 0 0 3.426 0 0 0 11.372 0 0 4.48098 0 0 0 A0A8C0NRV9 A0A8C0NRV9_CANLF ZW10 interacting kinetochore protein Canis lupus familiaris (Dog) (Canis familiaris) kinetochore [GO:0000776] GEAGGRARCRAPAQRGPSLPGP;GGDGGGGG;GGGDGGGG;KGGGGGGR 4 8.1 1.0033 -1.0565 0 0 0 0 0 0 10.6302 0 0 0 0 0 8.19692 0 0 A0A8C0NRW8 A0A8C0NRW8_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] VFCVCVSL 1 1 0.98545 -0.2586 0 0 0 9.56335 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NRY0 A0A8C0NRY0_CANLF Transmembrane protein 268 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LAAANGALLRHRVLLGVTDT;LGLSWHGFSPQLWFVY;SGDKAGAEDGVRD;SSEGRTSGDKAGAEDGVRDGGF 4 14.8 0.99192 -0.17117 10.2603 0 0 0 0 0 0 8.20271 8.22583 0 0 0 0 0 0 A0A8C0NRY3 A0A8C0NRY3_CANLF Akirin 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] REEYEQILNTLAEQYESFVKFTHD;YQRWRHLEVVLNQSE 2 20.4 0.99331 -0.17396 0 0 0 0 0 0 0 0 10.9506 0 0 0 0 0 8.2999 A0A8C0NRZ8 A0A8C0NRZ8_CANLF Ankyrin repeat domain 46 SNX31 ANKRD46 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] FLVSNGLKIDIC;GEGVLSSFRTT;NHQGATPLVL 3 14.6 0.98872 0.033 0 0 0 0 0 0 0 0 10.4399 0 9.42559 0 0 0 0 A0A8C0NS12 A0A8C0NS12_CANLF OCEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] transcription elongation factor complex [GO:0008023] QELQKDWP;VHLARRKIRIS 2 3.9 1.0038 -1.0689 0 0 0 0 0 0 0 5.52569 0 0 0 0 0 0 10.0949 A0A8C0NS22 A0A8C0NS22_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC24 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] AGALLCGA;AGVLLHISV;FLASPLPGDGITFQTAADVG;LFHGMLLL;LHAAGVLLH 5 16.9 1.003 -1.5341 0 0 8.83058 0 0 0 0 0 0 7.42744 0 7.73274 10.643 9.81027 10.2169 A0A8C0NS43 A0A8C0NS43_CANLF MIT domain-containing protein MITD1 Canis lupus familiaris (Dog) (Canis familiaris) LDQEKEENEQNV 1 10.7 0.95543 0.05044 0 0 0 0 0 0 0 0 0 0 8.76025 0 0 0 0 A0A8C0NS44 A0A8C0NS44_CANLF GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) GMPS Canis lupus familiaris (Dog) (Canis familiaris) glutamine metabolic process [GO:0006541] ATP binding [GO:0005524]; GMP synthase activity [GO:0003921] ATPGNEIPVE;EDLILCMQKM;KISQMPVILTPLHFDRDP;PALRGGCWIRLL;PDWESLIFLARLIPRMCH;PVKEPPTDVTPTFLTT 6 10 0.9862 -0.41466 0 7.71287 0 0 0 9.78439 13.1392 6.36198 10.1994 0 0 9.02042 0 0 0 A0A8C0NSC2 A0A8C0NSC2_CANLF Tyrosine-protein kinase (EC 2.7.10.2) JAK3 Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556] cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; membrane [GO:0016020] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] GVVLYELFTYGN;SSSEAGALHVLL 2 2.2 0.94137 0.10088 9.49017 8.67243 0 0 0 0 0 0 0 0 0 7.86573 0 0 0 A0A8C0NSD5 A0A8C0NSD5_CANLF Testis specific 10 interacting protein TSGA10IP Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EATRSLLQAWERQQEEERQQAEL;LGSEEIERVLS 2 6.1 0.9964 -0.58404 0 0 0 0 0 8.56259 0 0 0 0 0 0 0 0 0 A0A8C0NSE8 A0A8C0NSE8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ESFPLNSFLLK 1 9.2 0.98428 0.035491 8.64775 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NSF7 A0A8C0NSF7_CANLF threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) Canis lupus familiaris (Dog) (Canis familiaris) threonyl-tRNA aminoacylation [GO:0006435] cytoplasm [GO:0005737] ATP binding [GO:0005524]; threonine-tRNA ligase activity [GO:0004829] ETIERLQQLKQSRSKQAEEEF;KASGTVNI;LDRPLEEDCTLEL;PWPEYINTRLEMYNKLKAEHDSI;VGPTCDEYAQKVRQQFHDAK;WNQAEKQLE 6 13.1 1.0044 -2.0039 5.35329 6.48465 9.81282 0 0 0 12.4551 9.01962 6.99763 0 0 0 10.3172 9.65625 11.0426 A0A8C0NSF8 A0A8C0NSF8_CANLF CS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] cytoplasm [GO:0005737] unfolded protein binding [GO:0051082] QEPWNSEPPLSLSVAW 1 7.2 0.98209 -0.24921 0 0 0 0 0 0 10.7001 0 0 0 0 0 0 0 0 A0A8C0NSJ4 A0A8C0NSJ4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ETIPILLKLFRKI;NQKRPKIARGILKKT 2 3.4 0.9572 0.053874 0 0 5.39056 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NSJ8 A0A8C0NSJ8_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) AGCDSPPD;GCDSPPDSPAGAGF;GGGGGGGG;PGGGGGGG 4 9.4 1.0022 -1.2965 0 0 0 0 0 0 0 9.09059 0 0 0 0 4.30115 0 0 A0A8C0NSL4 A0A8C0NSL4_CANLF Otoancorin OTOA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADLLDIAMENQ;FLYELLSKS;QPQKLLEDLRDTDAQQFHTVMK;SFLAHFHYFEN 4 4.7 0.98721 -0.40649 0 7.90893 0 0 0 0 0 0 12.7021 0 0 0 9.11562 6.44521 0 A0A8C0NSN6 A0A8C0NSN6_CANLF OCA domain-containing protein POU2AF3 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; POU domain binding [GO:0070974] AAVAFAGPDPAAALLLLLLLLLR;CYCASCETEH;LLLLLLLL;LLLLLLLLL;NYNSPPSLDSRN;PRACRGQSLRRSLAWP 6 9.8 1.0043 -0.82075 0 0 5.70041 0 0 0 0 0 7.48816 0 0 2.05426 0 0 0 A0A8C0NSN7 A0A8C0NSN7_CANLF HAP1 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] EVLALRMESHDQQRRE;LVSEETEAWEEVEPQLDETTKQT;SDSEEEEEEEEEGEE;YSDSEEEEEEEEEGEEEEE;YSDSEEEEEEEEEGEEEEEEEEEEE 5 10.4 0.99195 -0.18 0 0 0 0 0 0 0 0 4.74071 0 0 0 10.1803 0 0 A0A8C0NSQ3 A0A8C0NSQ3_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] KSKQNEKNRTKR;LDARSPEYTEV;MEPDIPELEEIV;WRENGEDKRDRADLWP 4 4.5 0.9958 -0.084863 0 9.99379 6.12906 9.70383 0 0 0 6.19771 0 0 0 0 8.72083 0 0 A0A8C0NSR7 A0A8C0NSR7_CANLF "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (EC 2.4.3.2) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (ST3Gal I) (ST3GalA.1) (ST3O) (Sialyltransferase 4A)" Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]" DLEWVVSAT;KPAVRRQCDVWLQKC 2 7.3 0.98418 -0.24019 0 0 0 5.91571 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NSR9 A0A8C0NSR9_CANLF Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524] ECEENDGEEEG;EVECEENDGEEE 2 3.4 0.98226 -0.25129 0 0 0 7.41515 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NSS0 A0A8C0NSS0_CANLF "2-oxoadipate dehydrogenase complex component E1 (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [GO:0016624]; thiamine pyrophosphate binding [GO:0030976]" FCGQGIVPETFTLSNLPHF;FIWSQEEPQNM;GNTVNMFV;GVDGNTVNMF;PLNHMDPNQKGFLEVSNSPLSE;VVCQKTDDTFIPLNHM 6 8.5 1.003 -1.5341 0 8.89842 6.6585 11.036 0 0 0 0 10.9498 0 0 0 0 10.7986 0 A0A8C0NSU8 A0A8C0NSU8_CANLF Thyroxine-binding globulin (Serpin A7) (T4-binding globulin) SERPINA7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] PKNATFYKMSSI;QFLDDVKS 2 4.8 0.98786 -0.46014 10.7791 0 0 0 0 0 10.3745 10.4564 0 0 0 0 0 0 0 A0A8C0NSV4 A0A8C0NSV4_CANLF LRRNT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NLSSNKLWTVPTNM 1 3.2 0.93593 0.060913 0 0 0 0 0 0 0 4.99241 0 0 0 0 0 0 0 A0A8C0NSW0 A0A8C0NSW0_CANLF Olfactory receptor OR4D9C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EFAFLGLTQ;FFHLVGGVDVFSLS;LLTTLWFFLLLVSYMVILVVV;VLKLACTDIFMLELLMISN;VTTLLGNLLIM 5 23.8 1.0016 -0.7029 0 0 0 0 0 0 13.8205 0 7.30232 0 0 3.81588 0 0 0 A0A8C0NSX4 A0A8C0NSX4_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] LEPLLERISEDE;LSVAYIVVEL;NLELSFRVWQCGGKLE;SNKEIRFNSVTE;VGHVFPKRAPYARPNFLQN;VIDTIDWNTFEFYMQTGEP;VIIAFYNEAWSTLLRTIH 7 18.4 0.98973 -0.21703 10.2732 0 0 11.4104 0 12.0255 11.8549 0 0 0 11.5301 0 0 0 0 A0A8C0NSY2 A0A8C0NSY2_CANLF TRAF3 interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] AEALQKEQSITDC;EGGKEKEKWKDRERERERDKARDRD;ICAVKANVL;KEDKRNSEINERSTSR;KVEAETEISARASRSVTTKAP;PEPAVKQKGDS 6 12.9 0.97535 0.047166 0 0 0 4.83385 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NSZ9 A0A8C0NSZ9_CANLF LHFPL tetraspan subfamily member 6 LHFPL6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGFFMPYWLWGSQL 1 7 0.941 0.060971 0 0 0 0 0 0 0 0 9.158 0 0 0 0 0 0 A0A8C0NT02 A0A8C0NT02_CANLF Cardiomyopathy associated 5 CMYA5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATGTTIAVYWSM;EDTGLYSPDVASVSEHSLPPST;EIQPYSVN;EPEDSNLVEEEIIEL;EPQRYTFFYSGIVS;GDSVKSEASFPSRN;GPASLEGSEGDESEEESEEEE;GVLSRTQIF;ILHDTSVT;KDHEVATLDTAIS;LEYLEEKASFKTV;NLDSNIVS;NVVRSVPEESNISLC;PEESNISLCPSLD;PFSLVKTVSVTEKSGTVLL;RLTVKESYCIFED;SEEEEEPDASLSDQDE;SEPPVLEEPRR;SSIDITKESMKQ;SVLPDSVDEPKKD;TASLEKMPAAFSLF;VYIGTVQYKIKM;YFEKYTLI 23 7.4 1.0021 -2.5994 9.61693 7.94802 10.7417 8.72751 10.7956 8.93676 5.66497 11.4744 10.5483 9.77656 9.43811 0 10.2859 0 9.30221 A0A8C0NT47 A0A8C0NT47_CANLF Coiled-coil domain containing 142 Canis lupus familiaris (Dog) (Canis familiaris) LRAVLLRLLREREQLLQA;QAAVRLLRNPEP;RLRAVLLRLLREREQ 3 4.4 0.99142 -0.18243 0 4.74712 0 0 0 0 0 0 0 0 11.8461 0 5.80681 0 0 A0A8C0NT55 A0A8C0NT55_CANLF Cytosol aminopeptidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006] DTRPFTPDQLWRQP;ELKTRGFGG;GGQGHRAA 3 3.7 0.98986 -0.26592 0 0 0 0 0 0 0 0 0 0 12.0419 0 0 0 0 A0A8C0NT67 A0A8C0NT67_CANLF Thrombospondin type 1 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HSDEETICEPSGP;LCSLEECA 2 2.5 0.98943 -0.53139 0 0 0 0 12.7718 0 0 0 10.5927 0 0 0 0 0 0 A0A8C0NT73 A0A8C0NT73_CANLF "POP1 homolog, ribonuclease P/MRP subunit" POP1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] nucleolar ribonuclease P complex [GO:0005655]; ribonuclease MRP complex [GO:0000172] DPFPGTSRQRQTKMTYHSPVDP;GVPVDCAHSFIWNHAI;VLRSRKSLKQ;WIWFHPTLKQ 4 5.9 1.0026 -1.1264 8.13766 0 0 2.87505 0 8.86712 0 0 8.84815 0 0 10.2116 0 0 9.75535 A0A8C0NT78 A0A8C0NT78_CANLF Meiosis specific with OB-fold Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] DNA binding [GO:0003677] ISMLNIDDDTTTVVRHRCSG;PVNTIVDVYTVKQLKAKAS;TNPVNTIVDV 3 10 1.0036 -0.80524 0 0 0 0 0 0 0 9.83708 0 0 7.07927 0 0 0 9.18153 A0A8C0NTA0 A0A8C0NTA0_CANLF Coiled-coil domain containing 87 Canis lupus familiaris (Dog) (Canis familiaris) MKHDKVEMLYWLQ;NILQPSSEKIISL;YPPPLLEDEEP 3 7.8 0.99207 -0.28841 0 0 0 0 0 0 11.56 11.2367 0 0 0 0 0 0 0 A0A8C0NTB0 A0A8C0NTB0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ETPSQSKQIILASV;NEDTWPGV 2 12.2 0.94106 0.060964 0 0 7.10821 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NTB3 A0A8C0NTB3_CANLF IQ motif containing M Canis lupus familiaris (Dog) (Canis familiaris) APHSSWPSLYGSSSVFR;ESVGKKMEKEKHQH;LFKSEHFKEPSQGTSFKEPYIFS 3 11.7 0.99258 -0.16689 0 8.39343 0 0 0 0 0 9.46567 9.77007 0 0 0 0 0 0 A0A8C0NTC6 A0A8C0NTC6_CANLF Brain expressed X-linked 3 BEX3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] signaling receptor binding [GO:0005102] QENEEMEQPMQNGEEDRPL 1 17 0.95079 0.049553 0 7.94316 3.75371 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NTD0 A0A8C0NTD0_CANLF Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) RIOK3 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; ribosome biogenesis [GO:0042254] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] MYKMVNSGMLETITGCIS;PCPTVVLLKKH;PKLKEVKLSSEEMKEAYYQTLHLM;PKTRLLMYK;VLLKKHILV;VLLKKHILVMSFI;VVLLKKHI;VVLLKKHIL 8 13.1 1.0019 -2.626 6.09128 11.401 0 2.93949 8.42731 0 10.9451 0 11.4615 0 0 0 7.69718 0 0 A0A8C0NTF0 A0A8C0NTF0_CANLF Zinc finger FYVE domain-containing protein ZFYVE16 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872] ALKGKYIE;FIPDLDFHK;IDKNVCNKISLLPNDEDSLP;IYQTQANSATGHPRKV;LVEEEVDVAV;RHHCRACGKVFCGVC 6 5.5 0.98822 -0.22451 0 11.1161 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NTF1 A0A8C0NTF1_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD2 Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AIENCEYAFNLKKDE;MDTDLQPVTYSEPAFWCSIAYYE;SLVKKLKK 3 10.2 1.0023 -1.3006 8.46891 0 0 0 0 0 0 5.30681 0 9.90944 0 0 0 0 0 A0A8C0NTF4 A0A8C0NTF4_CANLF ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789] ADAVDDVEEQDVEEEEAAGGPL;GYTPQTDTSDDWEDIDSDEELEC;HCIAESWMNFSLFLQEMS;LYYLKTSYFWHGNFLKWHIIDSSY;YLSDLKGLIK;YTEDLTSVLGAN 6 9.7 0.99687 -0.087621 0 8.76825 10.1579 0 0 0 0 0 0 0 6.82731 0 0 0 0 A0A8C0NTJ2 A0A8C0NTJ2_CANLF "Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Sarcomeric mitochondrial creatine kinase)" CKMT2 Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] mitochondrial inner membrane [GO:0005743] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] NGYDPRVMKH 1 2.5 0.64463 0.32867 7.63154 0 0 0 0 0 0 0 0 0 0 0 10.8464 10.7301 10.6369 A0A8C0NTJ7 A0A8C0NTJ7_CANLF Oxidized low-density lipoprotein receptor 1 (Lectin-like oxidized LDL receptor 1) (Lectin-type oxidized LDL receptor 1) OLR1 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] extracellular region [GO:0005576]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] identical protein binding [GO:0042802] IINSTEDLEFIQQ;QKPNGKKAKGLH 2 9 0.9912 -0.20629 0 0 0 0 0 0 0 0 9.74712 0 0 0 0 0 0 A0A8C0NTK0 A0A8C0NTK0_CANLF "Small ribosomal subunit protein mS31 (28S ribosomal protein S31, mitochondrial)" MRPS31 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial small ribosomal subunit [GO:0005763] structural constituent of ribosome [GO:0003735] GVSHAMPV;NTICSKKDEQP 2 5.2 0.99547 -0.56424 0 12.3215 12.416 0 0 0 0 0 0 0 12.4157 12.478 11.9009 11.9702 0 A0A8C0NTM6 A0A8C0NTM6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM63 Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740]; zinc ion binding [GO:0008270] ASKGCQLG;IITQLEDSCRVTKENS;IQSLDEPG;MRKRKSSLKKKKIRKRKSPQRE;NMDYFTLDLEHIANTLR;RKRKSSLKKKKIRKRKS;RKSSLKKKKIRKRKSPQRERKKVRN;SLKKKKIRKRK;TPGSQAGSSLIQDGNPMENLEK;VARLPLVPFASL 10 23.8 1.0006 -2.7812 7.92778 7.6311 9.32537 0 0 4.16269 8.02995 0 11.5739 9.42599 0 0 0 7.09455 0 A0A8C0NTN5 A0A8C0NTN5_CANLF Kelch domain containing 4 KLHDC4 Canis lupus familiaris (Dog) (Canis familiaris) ALVEMDPGTQEWLEESDSEEDSNEG;DLHFYDATRNRWF;EMDPGTQEWLEESDSEEDS;PQSNEEDSPDEVGGPVVEPS;QEWLEESDSEEDSN;SEKRKRRRGK 6 13.7 1.0019 -1.3651 0 9.38282 9.37599 0 0 0 5.11187 0 0 0 0 0 0 6.9331 13.3383 A0A8C0NTN6 A0A8C0NTN6_CANLF ATP-citrate synthase (EC 2.3.3.8) ACLY Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] cytoplasm [GO:0005737] "acyltransferase activity, acyl groups converted into alkyl on transfer [GO:0046912]; nucleotide binding [GO:0000166]" GVAIGGDRYPGST;VVTKDGVYVLD 2 2.4 0.99456 -0.12678 9.38321 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9353 A0A8C0NTQ6 A0A8C0NTQ6_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LGPVFKQQE;LLRLQPLRPRGRR;LQKSQFFKGLP;QAQKLKSQQPLK 4 4.6 0.94818 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 6.5909 0 0 A0A8C0NTR9 A0A8C0NTR9_CANLF Protein max (Myc-associated factor X) MAX Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] RNA polymerase II transcription regulator complex [GO:0090575] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] QPPLQASGRKPPDNSRSADY;TDRVTWQGADRACVPPL 2 15.6 0.98785 -0.40219 0 0 0 0 0 0 0 0 0 0 0 0 0 14.8035 0 A0A8C0NTS1 A0A8C0NTS1_CANLF Uncharacterized protein C4H1orf131 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit biogenesis [GO:0042274] chromosome [GO:0005694]; small-subunit processome [GO:0032040] IFKKKKKRGQ;LQEELQCTPAVTPA 2 8.3 0.98943 -0.53177 0 0 0 0 5.01525 0 7.90274 0 0 0 0 0 0 0 0 A0A8C0NTT2 A0A8C0NTT2_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] GFSNTETLCSEYKYYCEE;IVEKIDAQ;QAIEEFYGL;VGRMEILMTVS;YKYYCEECR 5 7.6 1.0046 -1.0478 4.46682 0 0 0 0 0 4.85748 0 0 0 0 0 0 0 0 A0A8C0NTV8 A0A8C0NTV8_CANLF BTB domain-containing protein RCBTB1 Canis lupus familiaris (Dog) (Canis familiaris) ACGQTSSMAVLDN;FLQYLYTDAVDLPP;TDDVFACFATPAV;VENAFSLFSAAVRYDAEVT;VGSGSTTN 5 13.8 0.98503 -0.25339 0 0 0 0 0 0 0 0 0 0 0 0 8.47269 0 0 A0A8C0NTX0 A0A8C0NTX0_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVGVLVRAFIFVIPFVFLILRLLHA 1 11.7 0.97577 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 5.95958 0 A0A8C0NTZ7 A0A8C0NTZ7_CANLF Family with sequence similarity 174 member C FAM174C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LAALYFLIRAFRLKKPQ;LLLLLLLL;PLLPLLLLLLLLSAL 3 23.5 0.93935 0.1001 0 0 0 0 0 5.1348 0 0 0 0 0 0 4.31926 0 0 A0A8C0NTZ8 A0A8C0NTZ8_CANLF DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein CCAR2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DFGYRIYKM;KPRGEASEDL 2 3.3 0.9963 -0.57166 0 0 0 0 0 0 0 0 9.90537 0 3.16676 0 0 0 0 A0A8C0NU03 A0A8C0NU03_CANLF C2H2-type domain-containing protein IKZF4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LPGRLELPGSREAGEGPEDLADGGP;NICGYHSQDRYEFSSH 2 7.6 0.94576 0.084771 0 0 0 0 0 6.61894 0 0 0 0 0 0 8.95341 0 0 A0A8C0NU05 A0A8C0NU05_CANLF F-box protein 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ERPEAEAEAEAEAGAA 1 5.3 0.98972 0.021222 13.3995 0 0 0 0 0 0 13.5326 0 13.2808 0 0 13.2573 0 13.4232 A0A8C0NU12 A0A8C0NU12_CANLF Lipid-binding serum glycoprotein N-terminal domain-containing protein BPIFB1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] lipid binding [GO:0008289] LMLNLNEISSDRIHLMNSGIGLFN;LVKTIVEM;SSFLHSSC 3 7.2 1.0031 -1.6561 0 0 0 0 0 0 0 7.11103 0 0 0 0 9.59908 10.2055 0 A0A8C0NU14 A0A8C0NU14_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;ESGGDLVKPGG;EVLLVESG;EVLLVESGGDLVK;EVLLVESGGDLVKPG;EVLLVESGGDLVKPGG;GEVLLVESGG;GEVLLVESGGDLVKPG;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VRQAPGKGLQ 16 18 0 46.028 11.9492 11.9874 11.7964 11.3181 12.2174 11.4537 11.5076 13.1636 12.9517 11.8712 12.1043 12.0093 11.523 11.0481 11.4941 A0A8C0NU46 A0A8C0NU46_CANLF Cathepsin B (EC 3.4.22.1) CTSB Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; lysosome [GO:0005764] cysteine-type endopeptidase activity [GO:0004197] AEDMLTCCGDQCGDGC;CEPGYSPSYKEDKH;CGDGCNGG;CGDQCGDGCN;GDNEEQLE;MLTCCGDQCGDGCN;YQHVTGEMMGG 7 14.4 0.98935 -0.26564 0 0 0 0 0 0 0 0 0 0 0 0 0 13.3108 0 A0A8C0NU47 A0A8C0NU47_CANLF Circadian locomoter output cycles protein kaput (EC 2.3.1.48) CLOCK Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922]; DNA damage response [GO:0006974] cytosol [GO:0005829]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]" ATPQFIKEMCTVEEPNEEF;CGAVMVPSTMLMGQ;GHIGTTQHMIPQQTLQ;IWLQTHYYITYHQWNSRPEFIVC;LSVTQQQQ;VCTHTVVS 6 10.5 1.0032 -1.6115 0 0 0 0 0 7.22323 0 0 10.1163 0 0 0 7.03617 0 0 A0A8C0NU68 A0A8C0NU68_CANLF Senataxin Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] ADPLAGGDPTIHHLELATLKE;AKVSKERQELASKIKE;DDDDDEEE;DIVSYHENSYQ;IINNVSYNREIQNI;INNVSYNREIQNIRNS;ISDSDDDDDDEEEEE;IVSPSADP;KIEVKKRKRKRF;SDDDDDDE;SERNEDQPDI;VETPENQGEYCSKHCEAKAADEDVF;VGDGSERRDND;VGDPKQLPPTVISM;VISSLVTTQRKLK;YNKEESEQIERKSKKDLFCLENS 16 7.2 0.93794 0.089365 0 0 0 7.54473 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NU93 A0A8C0NU93_CANLF Gephyrin GPHN Canis lupus familiaris (Dog) (Canis familiaris) KHPFYTSPAVIMAH;SAYKIVPDEIEEI;VGVLTVSDSCFRNLAEDR;VIFAHCLFFTF 4 14.7 0.98176 -0.24943 0 0 0 10.3854 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NU94 A0A8C0NU94_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PAK4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] PGSPLPLT;SGGPQESSR 2 2.7 1.0027 -1.9086 0 0 0 7.72451 0 0 0 0 0 0 7.63546 0 0 0 0 A0A8C0NUA1 A0A8C0NUA1_CANLF Nck-associated protein 5 C-terminal domain-containing protein NCKAP5L Canis lupus familiaris (Dog) (Canis familiaris) GPSPEPPPSPLQVPTY;LSSAEGPTTSLPLGHC;PGGPGPPA 3 3.3 1.0018 -1.3054 0 0 0 0 6.8071 0 0 0 0 0 0 7.75756 0 0 0 A0A8C0NUB1 A0A8C0NUB1_CANLF Zinc finger CW-type and PWWP domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DDWSCDQNT;FGQCLVWVQCSSPNCE;HRQKDQLKKTVQVDSQIRNQ;LGAALMMAQEAEQISIQ;PKARGPKKKFRAPQRKDSVI 5 17.1 0.99692 -0.58865 0 5.42146 6.47831 0 0 4.28843 7.0797 0 11.3149 3.21576 0 0 0 0 0 A0A8C0NUB6 A0A8C0NUB6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;LRPFLAAAP;VGCGEFCD;WTVGCGEFCDFNGV 4 7.3 1.0031 -2.1545 0 0 10.1981 0 6.69864 0 0 5.94151 0 0 0 0 0 0 0 A0A8C0NUC5 A0A8C0NUC5_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] DLMHRIQLPDVESLRNFN;EEFRTWLREEWGRTLEDI;GGGGGGGA;GPGSAAHA;GSWAFLGVLWGDNLR;PPCSGGGG;SATVECMYGHRGP 7 11.1 1.0041 -1.9986 0 0 7.53629 8.60811 0 0 0 9.57561 0 0 7.88667 0 0 5.1758 0 A0A8C0NUD0 A0A8C0NUD0_CANLF Butyrophilin subfamily 1 member A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGEQLITITE;ELRWFRSQFSEAV;EVQVNMGTVAGPVNK;FLAWKQQQEKRRVW;GLGSGPHVFMVGPEDKGIRLTCR;NCFNTGRHYW 6 17 1.002 -1.2805 8.23228 0 10.6299 0 0 0 8.9722 8.66117 9.03009 0 0 0 0 9.2008 0 A0A8C0NUD2 A0A8C0NUD2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] plasma membrane [GO:0005886] ARRARLLLLLLLLLLFLLL;HAGGGSSG;ILGCEVEEDNSTTGFWKYGYDGQ;LLLLLFLLLQ;LLLLLLLL;LLLLLLLLL;LLLLLLLLLF;LLLLLLLLLL;LLLLLLLLLLFLLLQL;RARLLLLLLLLLL;RARLLLLLLLLLLFLLLQL;RLLLLLLL;RLLLLLLLL;RLLLLLLLLLLFLLLQLPTVAAQ;RRARLLLLLLLLLL;RRARLLLLLLLLLLFLLLQ;RRARLLLLLLLLLLFLLLQLP 17 13.9 1.0017 -1.2583 0 8.436 7.8166 4.45963 0 5.38398 0 12.6233 5.6302 3.80064 0 0 8.76732 5.95647 0 A0A8C0NUD3 A0A8C0NUD3_CANLF PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 Canis lupus familiaris (Dog) (Canis familiaris) ASHIISEDGD;EEEEEEEEEEEEEVENEEQ;EEEEEEEEEEEEEVENEEQD;FQMFTMQSSFSLECSHKHW;PAVEIPEEGFLLG;PEVRGNLMASGQ;VEFLQRLC;VLKKKKLVP;VQVQQYIKKLYILGG;YCSFYWCVCVHTA;YEEEEEEEEEEEEEVENEEQDSQN 11 10.9 1.0022 -1.2827 4.48897 8.12897 6.12319 9.53245 0 9.84757 10.8173 0 9.36034 0 0 6.18909 8.73704 0 0 A0A8C0NUD6 A0A8C0NUD6_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630] PTNNSASLRDE;QEVLQEPRSNVVK;WWLSESLLSL 3 4.2 0.98646 -0.42542 0 0 0 0 0 0 0 0 0 8.05045 11.2614 0 0 0 0 A0A8C0NUE0 A0A8C0NUE0_CANLF BPI fold containing family B member 4 BPIFB4 Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] ENAYGGHRGPGRYRSAEGAAAL;ETTICLID;GGGGGGGG;GGGGGGSG;GGSGGGKG;GGSGGGKGG;IKVKLLRGLLPNL;SGGGKGGG;TLQETNTVLRVT;VPMGKAGG 10 10.2 0.99694 -3.6637 11.2742 0 0 0 12.4039 12.4486 0 10.4245 10.381 10.7142 9.69818 13.9043 11.9637 8.8159 0 A0A8C0NUE3 A0A8C0NUE3_CANLF Ubiquitin-like-conjugating enzyme ATG10 (Autophagy-related protein 10) ATG10 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] ubiquitin-like protein transferase activity [GO:0019787] CSEGYMCKTHF;TCLPMEEALELPLD;WFSRYVAICWEDRWRRRSRSPA 3 11.3 0.97404 0.046699 0 0 0 0 0 8.02929 0 0 0 0 0 0 0 0 0 A0A8C0NUE8 A0A8C0NUE8_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AACQFSLKVTHYHCTRE;DDDDEDDDDDDEDLRT;DDDDEDDDDDDEDLRTDSEE;DDDEDDDDDDEDLR;DDEDDDDD;DDEDDDEDDEDDDDEDDDDDD;DDEDDEDDDDEDDDDDDE;DEDDDDDD;EDADDDEDDDEDDEDD;EDDDDDDEDLRTDSEES;EDDEDDDDEDDDD;EDDEDDDDEDDDDD;EDDEDDDDEDDDDDD;EDDEDDDDEDDDDDDEDL;EEDADDDEDDDEDDEDDDDE;ELPEEDADDDEDDDEDDEDDDDED;HYHCLDPECNYQ;SQGPPSLMD;VIEKWVNGEYSEE 19 5 1.003 -1.9428 9.55515 6.98413 8.25446 0 5.21128 8.63579 9.99534 8.81076 8.63332 0 0 0 9.23565 0 9.13927 A0A8C0NUF0 A0A8C0NUF0_CANLF ASCH domain-containing protein TRIP4 Canis lupus familiaris (Dog) (Canis familiaris) rescue of stalled ribosome [GO:0072344] nucleus [GO:0005634]; RQC-trigger complex [GO:0180022] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] FRHMSRLSKKITIDF;IVCEQEGSGPCFFCGTLVCTREEQ;QGNEDKKGQFIEEL;QKQFKDQVSMILLLK 4 12.6 0.95314 0.053888 0 0 0 0 0 0 0 0 0 0 0 0 0 6.11601 0 A0A8C0NUF3 A0A8C0NUF3_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] SSSGFGGG 1 1.7 1.0048 -1.1044 10.0204 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NUG5 A0A8C0NUG5_CANLF Protein NDRG1 (N-myc downstream-regulated gene 1 protein) NDRG1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] LTYHDIGMNRKFPQ 1 3.9 0.98652 -0.24584 0 0 9.87785 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NUG6 A0A8C0NUG6_CANLF "Beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.244)" Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] AGEEGQVEGEEGEEEEEEEE;ALLLLLLRPVKL;ALLLLLLRPVKLL;ALLLLLLRPVKLLR;DTIRKHCV;EEEEEEEEDMS;EEGEEEEEEEEEDMSEVFEYVP;GSPRAALLLLLLRPVKLLRRRF;LERGMWNRR;LLLLLLRPVKLLRRR;LLLLLLRPVKLLRRRF;LLLLLLRPVKLLRRRFR;LLLLLRPVKLLRR;LLLLRPVKLLRRRFRLLLAL;LLLRPVKLLRRRFRLLL;LLLRPVKLLRRRFRLLLA;LLLRPVKLLRRRFRLLLAL;LLRRRFRLLLALALV;QRPVRLSEY;RAALLLLLLRPVKLLRRR;SPRAALLLLLLRPVKLLRRRFRLLL 21 9 1.0025 -2.1758 5.76245 8.53181 5.61609 0 9.97025 5.42062 0 0 9.36971 4.49883 6.82248 10.2275 7.41836 5.09588 8.35865 A0A8C0NUG8 A0A8C0NUG8_CANLF Lipid-binding serum glycoprotein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] DEALPFLLQKIVC;IVCPLATT;LEGLLHITL;LSLQEILRLKVIKNIRIGVRL;QDSKVTAKLIQLLSLE;VHIDGHTATITQPGSLMLL 6 20.7 1.0025 -1.1397 0 8.00495 9.05691 0 0 0 0 0 0 0 0 8.06695 0 10.0689 9.91995 A0A8C0NUJ4 A0A8C0NUJ4_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PASVSGAL;SVLTQPASVS;SVLTQPASVSG 3 13.4 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 9.36413 0 0 0 6.10253 0 A0A8C0NUJ5 A0A8C0NUJ5_CANLF Serine/threonine-protein phosphatase with EF-hands (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) detection of stimulus involved in sensory perception [GO:0050906] calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; phosphoprotein phosphatase activity [GO:0004721] EAEGEAACEREGR;ISLDEFRQ;RWYRRYMARLE;TTERFLQDSEMEKGSDYESI;YAGQQDQVKLHDFF 5 9.1 0.93952 0.059752 7.31868 0 0 0 0 0 0 0 7.34465 0 0 0 0 0 0 A0A8C0NUN3 A0A8C0NUN3_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; chemotaxis [GO:0006935]; vasculogenesis [GO:0001570] plasma membrane [GO:0005886] chemokine binding [GO:0019956]; coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930] LYTLSFIYI;SDMSWPCNSSDCIVVDTVLCPNMP 2 9.6 0.99014 -0.19852 0 0 0 0 0 0 0 0 0 10.4986 0 0 7.55566 0 0 A0A8C0NUN7 A0A8C0NUN7_CANLF Olfactory receptor LOC119864987 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NPIIYGVKTKQ;VGNVIVLH;VGNVIVLHI 3 6.2 1.0016 -1.3124 0 0 0 0 0 0 0 0 0 0 0 0 3.23925 0 0 A0A8C0NUP3 A0A8C0NUP3_CANLF Histone H2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] LAVLLLRLGHRLLGALLRGRR;LLAVLLLRLGHRLLGALLRGRRG;LLQHLVHVHRVALLAAALALL 3 20.4 0.99628 -0.10982 0 0 0 0 5.60425 0 0 0 6.45523 0 0 0 0 0 0 A0A8C0NUQ3 A0A8C0NUQ3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) VKRWDTCTPMFIAAMAT 1 2.3 0.98276 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 9.23458 0 A0A8C0NUU4 A0A8C0NUU4_CANLF SRCR domain-containing protein MARCO Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664] GPPGAQGSKGDSGKPGPPGV;PGTAGSPGLAGLQ;RGRAEVYYNGVWGTICDDDWDNSDA;SKGDGGLVGPKG 4 15.1 0.98769 -0.4839 0 8.98704 0 0 0 0 0 9.60546 0 0 0 0 0 0 11.2558 A0A8C0NUV0 A0A8C0NUV0_CANLF NOP58 ribonucleoprotein NOP58 Canis lupus familiaris (Dog) (Canis familiaris) box C/D methylation guide snoRNP complex [GO:0031428]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] DEIIEKKAKKAKIKIKA;DKVDTMIVQA;EGKINKQLKKVLKKIVK;GVENRAKLEARLR;IIEKKAKKAKIKIKA;INKQLKKVLKKIVK;KKVLKKIVKEAHEPL;LKKVLKKIV;LPTCSKKRKI;QLKKVLKKIVK;SVGYAIFKVLNEKKLQEVDSLW 11 18.5 0.93595 0.1001 0 0 0 0 0 0 0 0 7.94644 0 0 0 0 0 0 A0A8C0NUW2 A0A8C0NUW2_CANLF Actin like 6A ACTL6A Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; SWI/SNF complex [GO:0016514] chromatin binding [GO:0003682] GKQGGPTYYI;SITCELFRNAEPRA;WNTRAKRE 3 7.4 1.0041 -0.81165 0 0 0 0 0 0 6.80025 0 9.49321 0 8.94904 9.17135 0 7.33762 10.2934 A0A8C0NUW6 A0A8C0NUW6_CANLF Profilin PFN4 LOC119881789 Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; manchette assembly [GO:1905198]; sperm flagellum assembly [GO:0120316] actin binding [GO:0003779] VVVVKTHLYLLVA 1 10.1 0.93955 0.059593 0 0 0 0 0 5.71677 0 0 0 0 0 0 0 0 0 A0A8C0NUX8 A0A8C0NUX8_CANLF PLAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EILLATSLCQALCLQ;NVFFYPQV;RKKFYIPV;YARDNSIVFAKQ 4 9 1.0033 -2.4482 7.10716 9.16133 0 0 8.004 0 0 0 0 0 10.2953 0 0 0 0 A0A8C0NV05 A0A8C0NV05_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILQLSCSDTWLLEMIGF 1 5.4 0.97758 0.047561 0 0 0 0 0 0 0 0 9.33994 0 0 0 0 0 0 A0A8C0NV10 A0A8C0NV10_CANLF Leucine rich repeats and IQ motif containing 1 Canis lupus familiaris (Dog) (Canis familiaris) AWLCNENENLFSSEHAQF;DIATAQQML;EILRCGPWNTLQ;EVKNENLAKQQYKK;EWHTEEYYQPELA;FTFDEAAL;LKRAQKMKSKKLRK;QGNYLTELPSL;SKEYTYQWLHTQVGIHETT;WLCNENENLFSSEHAQF 10 7.3 0.93687 0.060945 0 0 0 0 0 0 0 0 0 0 0 0 0 11.632 0 A0A8C0NV11 A0A8C0NV11_CANLF EF-hand calcium binding domain 14 EFCAB14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LHNSLEEVNSALVGYQRQN;QEIPKLNEELLSNQKQVEKIE 2 8.9 0.94187 0.10219 0 0 0 0 0 0 11.052 0 0 0 0 0 7.65935 0 0 A0A8C0NV50 A0A8C0NV50_CANLF histone acetyltransferase (EC 2.3.1.48) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleosome [GO:0000786] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] CFKNADPCRNNMD;DNMLFCDSCDRGFHMECCDP;DQSPQIATTLDDCQ;EEEEDEEPSHNEGHDADDEDDSHM;EEEEEEDEEPSHNEGHDADDEDDSH;EEEEEEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEVEEEEEEEEN;ESSEEEEEEEEEEEEEEEE;IKRKRPFVLKKKRGRK;IKRKRPFVLKKKRGRKRRR;IYGRSQTVAMQGP;KPEEEEEEEEEEDDEEE;KRKRPFVLKKKRGRKRR;LTKPQSVAIKRKRPFVLKKKRG;PEEEEEEEEEEDDEEEEEE;PEEEEEEEEEEDDEEEEEEEEEE;RKRPFVLKKKRGRKRRRI;SEEEEEEEEEEEEEEEEEEEEEEEE;SYAQISPDQSAISVPSLQ 19 11.9 0.089109 0.92529 11.7073 8.44365 11.808 7.1298 0 8.89954 0 8.36942 13.0192 0 5.45012 5.05645 7.87756 0 8.3175 A0A8C0NV53 A0A8C0NV53_CANLF Tight junction protein 2 TJP2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] EEVGEGSEEQEGA;LVSSITRSSEPVQHEES;SEGKMEGMDDDP;VLFLFFVCRENDRVVM 4 5.5 0.98343 -0.25177 0 0 0 0 0 0 7.61522 0 0 0 0 0 0 0 0 A0A8C0NV72 A0A8C0NV72_CANLF Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) MED17 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] FKEVQWNKMEGRNFVYK;QFPRNQCKDL;QFPRNQCKDLPKSDVLQDSKWN 3 6.4 0.9893 -0.51833 8.0656 0 0 7.80568 0 0 0 0 0 0 0 0 9.32939 0 0 A0A8C0NV77 A0A8C0NV77_CANLF beta-N-acetylhexosaminidase (EC 3.2.1.52) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] beta-N-acetylhexosaminidase activity [GO:0004563] LPRDRGSSRLGH;TTDFTGEGAG 2 2.8 0.98712 -0.49937 0 0 9.92821 0 0 0 0 0 0 0 0 0 12.7957 0 0 A0A8C0NVB2 A0A8C0NVB2_CANLF Olfactory receptor OR51L2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YFIHTFSLM 1 2.8 1.0038 -0.80421 0 0 0 0 2.66321 0 0 11.3457 0 0 0 0 0 0 0 A0A8C0NVD7 A0A8C0NVD7_CANLF Taste receptor type 2 LOC100682759 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] AIVWSSNRL;LTSFLLLIFSLWKHLKKMRSSGKR 2 10.7 0.99314 -0.14326 0 0 0 0 0 0 4.04002 0 0 0 0 0 10.3455 0 9.73466 A0A8C0NVE5 A0A8C0NVE5_CANLF ARVCF delta catenin family member ARVCF Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] cadherin binding [GO:0045296] EGGPELEPD;NFNTLEAAAGALQNL;TLPLVDKSLGEY 3 3.8 1.0015 -0.69356 0 10.6677 0 0 6.82107 0 0 0 0 9.37853 0 0 0 9.37226 0 A0A8C0NVE6 A0A8C0NVE6_CANLF Leucine rich repeats and IQ motif containing 3 LRRIQ3 Canis lupus familiaris (Dog) (Canis familiaris) FVKLKNICML;KNQKAEDRLLIQN;KPQEKFISE;LEKVRERR;QPSSTTHQKPAIKKKDMLLKSN;YAALLKGKEHYYFPTCVQPSSTTHQ 6 12.7 0.99036 -0.53514 0 0 0 0 0 0 8.54067 0 11.1204 0 0 10.8973 0 0 9.78828 A0A8C0NVG3 A0A8C0NVG3_CANLF Keratin 15 KRT15 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] keratin filament [GO:0045095] structural molecule activity [GO:0005198] ELTLSRAD;ELTLSRADLEMQIET;GDGLLVGSE;LGGGYGGG;TVQNLEIE;VEMDAAPGVDLSRILN 6 10.9 0.98996 -0.26657 0 0 8.91226 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NVH9 A0A8C0NVH9_CANLF Partner and localiser of BRCA2 WD40 domain-containing protein PALB2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] DNA binding [GO:0003677] DNLSADENQ;EKRQSKLPGRRKKQ;ETVLTFAEVQGMQEAL;SGQLPQSPDLEPD;VCTETVRPTCSTPQLPHLKDSDHV;VSGRDGQPSCDC 6 6.5 0.99405 -0.28521 7.52865 0 0 0 6.62022 0 0 0 8.78709 0 4.17121 0 0 0 0 A0A8C0NVI6 A0A8C0NVI6_CANLF Zinc-finger CCCH domain-containing protein C15H12orf50 Canis lupus familiaris (Dog) (Canis familiaris) ALGSDTVCSLWREG;EITMSKCS;REDPSSMND;TVCSLWREGK 4 7.5 1.0028 -1.586 0 0 7.39335 0 0 0 0 10.2642 0 0 0 0 0 12.8647 9.94089 A0A8C0NVK8 A0A8C0NVK8_CANLF Corticotropin-releasing factor domain-containing protein UCN2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755] extracellular space [GO:0005615] corticotropin-releasing hormone receptor 2 binding [GO:0051431]; hormone activity [GO:0005179] TGTPSPAF 1 7.1 1.0048 -1.1044 0 7.75849 0 0 6.63757 0 0 0 0 0 0 0 0 0 0 A0A8C0NVM2 A0A8C0NVM2_CANLF Serpin H1 (Collagen-binding protein) SERPINH1 Canis lupus familiaris (Dog) (Canis familiaris) collagen fibril organization [GO:0030199] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ATAFEWDTEGNPFDQD;LASVFHATAFEWD 2 10.9 0.92045 0.10897 0 0 0 8.71146 0 6.06003 0 0 0 0 0 0 0 0 0 A0A8C0NVN2 A0A8C0NVN2_CANLF Shroom family member 3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule [GO:0005874] actin filament binding [GO:0051015] DHCSSQGSMESLE;GDLGPAGTDTSDSCPED;GNSPHPSERKSTH;KAMQRTINCAGYEGKR;KSAFSSLQ;PAGRCTLSGVF;PDSRMKTTMDLM;PKAGALAL;PPLSQDTPVNSS;SLEPHFAQ;SPHQQVSSLGRRWLS;TSSIDQLSHLHNKRDSA 12 7.9 0.99918 -3.2128 0 9.07935 0 0 12.9194 9.46101 0 0 11.1935 3.603 6.05452 2.65624 0 0 0 A0A8C0NVQ0 A0A8C0NVQ0_CANLF C-type lectin domain-containing protein CLEC19A Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] DGWMDGWMDGL 1 4.7 0.98141 0.035491 0 0 0 0 0 0 7.86456 0 0 0 0 0 0 0 0 A0A8C0NVQ1 A0A8C0NVQ1_CANLF GATA-type domain-containing protein GATA6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] GGAAGGGA;GGVGGGGG;LLTRDPEA;NHAGGAGA;SSSSSCCSRAGERGPG;VGGGGGGG;YAAAGGGGA 7 9.5 1.0032 -2.3627 0 0 0 9.4035 9.48653 9.63773 0 0 0 7.9782 9.016 0 0 0 0 A0A8C0NVR2 A0A8C0NVR2_CANLF NLR family pyrin domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleus [GO:0005634] ALWVPVTDA;IHKPPPLA;SPIGVLLRTIHAALRFLP;TPSQMRKLFSFSR;VDTSLFYAAH;VLSEEQYERVRAE;YHLAHRCLQEFF 7 7.6 0.99357 -0.16215 0 0 0 0 0 0 0 0 0 0 9.75394 0 0 0 0 A0A8C0NVR3 A0A8C0NVR3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EADYLIYE;TVVTQEPSL;TVVTQEPSLSVSPG;VSTGNKPG 4 21.6 0.87122 0.14201 9.23146 0 9.37173 8.40135 8.49406 0 0 0 9.77671 9.67426 9.05162 0 0 8.46054 10.3137 A0A8C0NVT0 A0A8C0NVT0_CANLF Paralemmin-1 (Paralemmin) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] apicolateral plasma membrane [GO:0016327]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; lateral plasma membrane [GO:0016328]; synapse [GO:0045202] EDETKVVHAVDGTAENG;EDVYSPASTEVPTPELAC;ELVVIEDAAEPKEPAPPNGSAAE;PTLPDRGGEMEVL;VGPPGDTGSTQDSRQNVR 5 9.2 1.0018 -0.67666 9.99081 0 0 0 0 0 0 0 0 4.4119 0 0 0 0 0 A0A8C0NVU3 A0A8C0NVU3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLTVHPNVQDPD;FTQYPTLFWYVQYPN;IGLRILLL;LVIGLRILLLKVIGFNL 4 17.4 1.0039 -0.80815 8.51511 0 0 0 0 0 0 0 8.68839 0 0 0 10.003 9.06883 8.9818 A0A8C0NVY8 A0A8C0NVY8_CANLF Testis specific 10 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HMDSMKEQEDGCC 1 2 0.93989 0.059561 0 0 0 4.46172 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NVY9 A0A8C0NVY9_CANLF Alpha-mannosidase (EC 3.2.1.-) Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] EIAFFSRWWQQQT;PYGSGDSAPLNEA;RFDPDTGFLVELENLE;SSSCCCCHQW;VAPRKQHSRDVASPGSV;VISRFDTVLETKGLFYT;VLFFFLGGGGYLT 7 9.1 0.99177 -0.54407 0 0 0 0 0 0 8.8909 0 4.19117 0 0 0 0 0.401303 4.37976 A0A8C0NW29 A0A8C0NW29_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mRNA processing [GO:0050684]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] PRTTARVRP;VLTGKLSKNKRKKMRRKRKQQKRL 2 4.8 0.98506 -0.25781 0 0 0 0 5.55253 0 0 0 0 0 0 0 0 0 0 A0A8C0NW44 A0A8C0NW44_CANLF Winged helix Storkhead-box1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] AGEASEPP;FEGTKNGQTLTSN;FPDPCPPNVETPAA;LQVLKGNECYRPSGFFT;TSVSFLHPMLCLTAELWGP;VGHASSAC;WNSRLARAASRLA 7 8.8 1.0024 -2.5882 0 9.14509 0 6.19217 0 7.80226 9.49528 6.51442 0 0 0 0 0 0 0 A0A8C0NW67 A0A8C0NW67_CANLF Lipid-binding serum glycoprotein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] HLGTLIGLN;KLVLPVVLL;RCAHSWTPCSRGP;VGPESQIRYSMTNAPNIT 4 10.1 0.98551 -0.42968 0 0 0 0 0 0 0 0 0 9.91489 10.8424 0 10.8996 0 0 A0A8C0NW72 A0A8C0NW72_CANLF Twinfilin-1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779] FVLPLLEDKQPCY;LFRLDSQNAQGYEWIFIAW;RHPNLIVCPIPLTLI 3 10.4 0.99432 -0.1616 0 0 0 8.93861 7.93705 0 0 0 0 0 0 0 0 0 0 A0A8C0NW75 A0A8C0NW75_CANLF "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" LOC606856 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ADRRNPRATWGGSSTV;DFKFLKTIPRLTILFRPLRLIILI;FKFLKTIPRLTILFRPLRLIIL;IPRLTILFRPLRLIILIRVF;LRLIILIRVFH;MVAFTKEVDEW;PPLYDDVKVQFFSSSDL;RLKKNPLYLWLMHQKNNNRV;TILFRPLRLIILIRV;VISEIPALSE 10 13.8 0.91852 0.11423 9.46573 0 0 9.10696 0 0 0 7.64313 6.81173 6.36973 9.25857 0 0 6.70791 0 A0A8C0NW82 A0A8C0NW82_CANLF Ribosomal protein L32 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ALRPLVKPKIIKKRTK;ALRPLVKPKIIKKRTKK;IIKKRTKKFI;IQHQSDQYVKIK;MAALRPLVKPKIIKKRTKKFIQ;PKIIKKRTKKFIQHQ 6 23.9 0.73623 0.24647 0 0 8.56213 0 0 7.61934 6.74039 6.45251 0 0 0 0 0 4.55723 7.97785 A0A8C0NW89 A0A8C0NW89_CANLF Globin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744] blood microparticle [GO:0072562]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] haptoglobin binding [GO:0031720]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] AAYQKVVAGVANALAHKYH;ANALAHKYH;EVGGEALGRLL;GKVNVDEVGG;GVANALAHKYH;IKHMDDLKDTFAELS;KVVAGVANALAHKYH;PENFKLLG;PENFKLLGNVL;QKVVAGVANALAHKYH;TFAKLSELH;VANALAHKYH;VVAGVANALAHKYH;YQKVVAGVANALAH;YQKVVAGVANALAHKYH 15 27.5 0.99263 -0.14101 0 0 0 0 0 0 0 0 0 0 0 0 0 9.98613 0 A0A8C0NW97 A0A8C0NW97_CANLF Membrane palmitoylated protein 4 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] ATTHAQTVVGILRE;DHVIVNDNLQD;DLAQKMETQFGQFFDH;LDVTSCAFLP;VIVNDNLQDA;YHYVSKET 6 9.5 0.94207 0.061086 0 0 0 0 0 0 0 0 0 0 0 0 0 6.27696 0 A0A8C0NW98 A0A8C0NW98_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] HPGFSDAYQDYEEYWRAY;IIRHYTGPGDH;ISGNMNQNQRL;NMNQNQRLDA;PYSLTFIELVEDYEHYINEG 5 7.7 0.98519 -0.43957 10.1494 10.4738 0 0 4.70282 0 0 9.15543 10.429 0 0 0 0 0 0 A0A8C0NWB6 A0A8C0NWB6_CANLF Calcium binding protein 39 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] protein serine/threonine kinase activator activity [GO:0043539] LVAMKEILY;PQVKQAERSEASVAAAMPFP 2 8.3 1.0024 -0.84293 0 0 10.515 0 10.2873 0 0 0 0 8.39951 0 0 0 0 0 A0A8C0NWC2 A0A8C0NWC2_CANLF Latent transforming growth factor beta binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CEDHDECQDMACE;CEDVDECEDL;CEDVDECEDLQ;CIDIDECANDTMCGSHGFCD;ECCCQDGEA;EDHDECQDMACENGEC;FCSPPLTLDL;GGRCTNTEGSYHCQC;GLNLTEKIKKIKIVFTP;HDECQDMACENGECVNT;HYNAVHRKCEDHDE;IDIDECANDTMCGSHGF;IDIDECANDTMCGSHGFCDNT;LGHTCEDVDECEDLQS;PPPPTPPP;PTGDCIDIDECANDTMCGSHGFC;QAECCCTQGASWGDTCDPCPAED;SYHCQCDQ;TTQAECCC;TYTECCCQDGE;TYTECCCQDGEAWSQQCAL 21 9.4 1.0044 -1.1044 0 0 0 0 0 0 0 0 9.39712 0 0 0 0 0 0 A0A8C0NWC7 A0A8C0NWC7_CANLF Zinc finger CW-type and PWWP domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EVPACSPFENHYEEDYLF 1 5.4 0.96998 0.048313 0 6.69961 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NWD7 A0A8C0NWD7_CANLF Tomoregulin-1 MSANTD3 TMEFF1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DNGSGSGEGEEEGS;GGGGGGDC;GGGGGGGD;GGGGGGGG;MPCPENLNGYCIHGK;PGGGGGGG;PPGGGGGGG;YKAECDEDAENVG 8 15.3 0.98762 -0.36929 9.35021 0 0 0 6.25461 3.95801 0 10.1173 0 0 0 9.74704 0 0 0 A0A8C0NWF0 A0A8C0NWF0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) deoxyribonucleotide biosynthetic process [GO:0009263] membrane [GO:0016020] oxidoreductase activity [GO:0016491] WIEDRKSTF 1 3 0.98578 -0.23588 0 0 0 0 0 0 0 0 0 0 11.3951 0 0 0 0 A0A8C0NWF1 A0A8C0NWF1_CANLF Growth arrest specific 2 like 3 GAS2L3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] KPPARVRNLLQRRK;NFLHWCRHIG 2 3.6 0.98403 -0.23965 0 0 0 0 0 5.50418 0 0 0 0 0 0 0 0 0 A0A8C0NWF2 A0A8C0NWF2_CANLF small monomeric GTPase (EC 3.6.5.2) KRAS Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ARSYGIPFIETSAKTRQR;GGGCPAST;GGGGGGGG;KTPGCVKIK 4 12.3 1.0036 -1.6059 0 6.15269 0 0 0 0 0 10.7766 10.5285 0 0 0 0 8.20496 8.09292 A0A8C0NWF3 A0A8C0NWF3_CANLF Low-density lipoprotein receptor-related protein LRP6 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; chemical synaptic transmission [GO:0007268]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; Wnt signaling pathway involved in somitogenesis [GO:0090244] plasma membrane [GO:0005886]; synapse [GO:0045202] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] AGDLKIFEIE;ALTLFEDTLY;FYQCACPTGV;VHGPASVP;WNECASSNGHCSHLCLAVPVGGFVC 5 4 1.0032 -2.2979 0 0 0 0 0 0 0 0 10.1029 0 0 8.16536 7.60118 0 0 A0A8C0NWF4 A0A8C0NWF4_CANLF Homeobox protein engrailed-like Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GAEGGGGA;GGGGGGGD;GGGGGGGG;LDGALKAR;PGGGGGGG;PLPGGGGG 6 10 1.0036 -2.2088 7.38189 4.48678 9.10006 0 0 0 0 0 0 0 0 4.29057 0 7.58737 0 A0A8C0NWG0 A0A8C0NWG0_CANLF A disintegrin and metalloproteinase with thrombospondin motifs 4 (EC 3.4.24.82) (Aggrecanase-1) Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] APELLGGAEPGT;TLLLELEQ 2 2.4 1.003 -0.73612 0 0 0 0 0 0 0 0 0 9.63791 0 0 0 0 0 A0A8C0NWG7 A0A8C0NWG7_CANLF GRAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGSLALAG;SRKPPGSENAVCEEEKLEESRS;VYDMLRRVCTHLQPS 3 7.8 1.0021 -1.0012 0 0 0 0 0 0 0 0 0 0 0 8.06458 0 12.4265 0 A0A8C0NWI3 A0A8C0NWI3_CANLF Albumin domain-containing protein AFM Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] FSNVVVTCCKAEGP;SSKYNGCCEGDA 2 4.6 0.87631 0.1264 0 10.0847 7.09106 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NWJ8 A0A8C0NWJ8_CANLF Latent transforming growth factor beta binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CEDHDECQDMACE;CEDVDECEDL;CEDVDECEDLQ;ECCCQDGEA;EDHDECQDMACENGEC;FCSPPLTLDL;GGRCTNTEGSYHCQC;GLNLTEKIKKIKIVFTP;HDECQDMACENGECVNT;HYNAVHRKCEDHDE;LGHTCEDVDECEDLQS;PSPESGECVDIDECANDTMCGSHG;QAECCCTQGASWGDTCDPCPAED;SYHCQCDQ;TTQAECCC;TYTECCCQDGE;TYTECCCQDGEAWSQQCAL;VLWADTWGIDRC 18 9.6 0.99412 -0.18876 0 0 0 9.53477 0 5.73382 0 0 0 0 0 0 0 0 0 A0A8C0NWK1 A0A8C0NWK1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) LRIARGILKKKTIAGGITMP;VWNQKRLRIARGILKKKTI 2 3.8 0.97338 0.048206 0 0 0 0 0 0 0 0 0 5.47742 0 0 0 0 0 A0A8C0NWK7 A0A8C0NWK7_CANLF CUGBP Elav-like family member 2 (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP- and ETR-3-like factor 2) (RNA-binding protein BRUNOL-3) Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730] IRVMFSPFGQIEEC;LQQATSSS;PKSAVTMRNEELLLSNG 3 7.6 0.99294 -0.15166 6.01143 0 0 0 7.98829 0 0 0 0 0 0 0 0 0 10.1338 A0A8C0NWL9 A0A8C0NWL9_CANLF WSC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] AERSYVYAGLEAG;PGPRAPGPLQAL;VENNKEGSFRRR 3 6.4 0.93699 0.074334 0 9.87217 0 0 0 0 0 8.34003 0 8.97711 0 0 10.4068 0 9.73207 A0A8C0NWP6 A0A8C0NWP6_CANLF Olfactory receptor OR51F23 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AYVHTMIA;LSQMFFIKLF;SLHEPMYYFLSM;STVGVDSILILLSYILIIKTV;VGVDSILILLSYILIIKTVLSIASP 5 18.3 0.99184 -0.54282 0 0 0 0 0 0 0 0 0 0 0 0 12.1446 0 0 A0A8C0NWQ0 A0A8C0NWQ0_CANLF Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) Canis lupus familiaris (Dog) (Canis familiaris) Rab-protein geranylgeranyltransferase complex [GO:0005968] metal ion binding [GO:0046872]; Rab geranylgeranyltransferase activity [GO:0004663] AAGGSAVSYAAARE;SPVFCMPEEVLRRVNVQ 2 7.2 0.80191 0.20788 0 0 0 0 0 0 19.8964 13.7223 0 0 0 0 0 0 0 A0A8C0NWQ5 A0A8C0NWQ5_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; stimulatory C-type lectin receptor signaling pathway [GO:0002223] external side of plasma membrane [GO:0009897] transmembrane signaling receptor activity [GO:0004888] TSLEITTQKGLYCGH;TYVCKHQI 2 8.3 1.0034 -1.0362 0 0 0 0 0 0 0 0 10.3073 0 0 0 0 0 8.48888 A0A8C0NWR3 A0A8C0NWR3_CANLF APCDD1 domain-containing protein APCDD1L Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178] plasma membrane [GO:0005886] Wnt-protein binding [GO:0017147] LLGGILPP;SLLIKGKVRLRRA 2 4.2 1.0044 -1.1044 0 0 0 0 0 0 0 0 12.3038 0 0 0 0 0 0 A0A8C0NWS0 A0A8C0NWS0_CANLF Synaptonemal complex protein 2 SYCP2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] ESKKLLTIILKNIIKIS;HMKQKSPSSISE;IEVMRCTEKI;KKLLTIILKNIIKISKRE;PILLTNTSAPRRGRTK;RRKFHVRQKI;SLKDLEKEFV;YFTKQSWKTAQQHLNTMNQQIQ 8 7.1 0.99935 -0.61146 0 0 0 0 0 0 0 0 6.49528 0 0 0 0 0 0 A0A8C0NWS7 A0A8C0NWS7_CANLF Notchless protein homolog 1 RFFL Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; Notch signaling pathway [GO:0007219] nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677] LVRGQGPERLV;QEMVDIGTWGPPEQS;TGKYLASGSGD;VGLYTGEVTE;VRFWDLSTETPHFTCQGHRHWVL 5 7.2 0.94692 0.061386 0 0 9.21963 6.56221 9.06663 6.5888 0 0 0 12.5581 0 8.6268 0 0 9.82888 A0A8C0NWT4 A0A8C0NWT4_CANLF Glypican 2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] ALSARPGV;LQLRAATTRMKVAA 2 3.5 1.0024 -1.3589 0 0 0 0 0 0 0 13.135 0 0 0 0 0 0 12.1456 A0A8C0NWT5 A0A8C0NWT5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IHTVVAQRSLHQ;PGLQESRALLVL 2 7.4 0.98706 -0.2351 0 10.0653 0 4.47483 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NWU7 A0A8C0NWU7_CANLF PKHD1 ciliary IPT domain containing fibrocystin/polyductin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ELPLITASIV;ETSGFYVDEIIIA;GVGGAKPM;GVSRRKVSRRAVR;IEPKEGSLAGGTWIT;KPMEEIVIVE;KTPKLELVGG;LLCPDLRRERQ;LLLGHFAHKGSL;NPLEKEQKLLILLR;NSSDLTVMEDLKSCYEHEWTLSW;NSSSKEFSGVLQ;NVTVIVNGLPS;SECQGNCTLFLQEETT;SFFLTWDNVTSEPIP;SNFVKSCYSD;TASIVPTGGEARRS;TDSRNKTTTVNYV;TVSGRGSFFLTWDNV;VGHGIDLEGQN;VGTLDNPLEKEQKL;VILLGVSHCDLETQTLRNNVS;WPIFTSEPNWWP;WSDNVAHSSLHGLHL;YEAAMTPVVTAMRGEI;YSLQFETP;YTFWIQADNQAS 27 8 0.99692 -6.3754 13.2832 10.7397 9.20173 0 7.93393 10.2706 9.08015 13.2144 0 0 8.22482 8.48293 9.75572 11.6519 7.53699 A0A8C0NWV2 A0A8C0NWV2_CANLF S100/CaBP-9k-type calcium binding subdomain domain-containing protein S100A13 Canis lupus familiaris (Dog) (Canis familiaris) AEPLTELEAAI;EEWTQGVKA;IQKERALEIRKNRGEAEEW 3 18.3 0.98749 -0.36137 0 0 0 0 0 6.22743 0 0 0 0 0 0 9.19977 0 0 A0A8C0NWV3 A0A8C0NWV3_CANLF Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274] GGGGGGGE;GGGGGGGG;PVEQDTDISGLE 3 5.9 0.99325 -0.17065 0 0 0 0 0 0 0 0 0 0 0 0 12.7876 0 0 A0A8C0NWW4 A0A8C0NWW4_CANLF Acyltransferase (EC 2.3.1.-) Canis lupus familiaris (Dog) (Canis familiaris) diacylglycerol metabolic process [GO:0046339]; glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789] diacylglycerol O-acyltransferase activity [GO:0004144] ILMYTFCTDCWLIAVLYFTWL;PGDGGSGGE;VGGAAESL 3 10 1.0023 -1.017 8.4623 0 0 0 5.57933 0 9.28981 0 0 0 0 0 0 0 0 A0A8C0NWW6 A0A8C0NWW6_CANLF HECT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] ELFQSVHGWLMV;EWAPGTQREIDEFFKA;LFQSVHGWLMVLYE;LSQLYLTMLVTFTDTS;MIWDGIVENAKGETLE;TRMFSTPELQRLISGDNAEIDLE;VSLALSKDLTLLWIKQIKHVLW 7 10.1 0.81778 0.20008 0 0 10.3703 0 8.80909 8.55351 0 0 0 0 0 0 0 8.01486 0 A0A8C0NWZ1 A0A8C0NWZ1_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; regulation of cell differentiation [GO:0045595] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAPGGHGE;GWTARESHEGTQ;PAAVPEASRRRRGPEGAG;PAREPTGALARGARPDAAMSAA;SNHKAGAG;VEQLTRDLAGLRQFFKQLP 6 16.6 1.0024 -1.1717 0 10.1189 0 0 7.72028 7.19554 0 0 9.02428 0 0 0 0 11.341 8.15532 A0A8C0NWZ7 A0A8C0NWZ7_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP3 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] GPVCSLRDCLRSFTDLEELDE;IPSQFRNKRSKNQEN 2 7.6 0.94162 0.10156 0 0 0 0 8.24997 0 10.2562 0 0 0 0 0 0 0 0 A0A8C0NX04 A0A8C0NX04_CANLF Sodium channel protein Canis lupus familiaris (Dog) (Canis familiaris) membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228] axon [GO:0030424]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] DALRIQMEDRFMASNPSK;IRLARIGRILRLIKGA;LAPILNSAPPDCDPDTIH;LEDLDPYYI;LFVPHRHG;NKCLQWPPS;PLSEDDFEMFYE;PVRKIAIKILVH;QLKKQQEEAQ;RVIRLARIGRILRLIKGAK;SELGAIKSLRTLRALRPLR;SSEGSTVDVAPPREG;TSPTGQLPPEG;VEHNWFET;VGAGYLAL;VGSENDFADDEHSTFEDS;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGIRTL;VIRLARIGRILRLIKGAKGIRTLL;VIVMAYVTEFVDLG;VLRSFRLLRVFKLAKSWPTLN 22 11.8 1.0035 -2.0319 9.23735 0 0 0 7.94521 0 12.6096 6.07936 13.3682 0 0 0 0 0 9.69464 A0A8C0NX10 A0A8C0NX10_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IENPEVDPELYGQLIFGK;REIQIKTTT 2 4 0.98983 -0.22363 0 0 9.14863 0 0 8.03249 0 0 0 0 0 0 0 0 0 A0A8C0NX39 A0A8C0NX39_CANLF Syntrophin alpha 1 SNTA1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; methylthiotransferase activity [GO:0035596]" FTYLLDQVS;LLDQVSRVDPEMRIRFTSPHPK;LLLQRRRV;LPRLLAVAESGQQ;RGCDNMCSYC 5 5.3 1.003 -2.1514 6.75756 10.6917 0 0 0 0 0 10.0925 0 0 0 0 0 0 11.809 A0A8C0NX40 A0A8C0NX40_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "interleukin-1, type II, blocking receptor activity [GO:0004910]" AADNSRMKALTWVV;VKEAASFSWGMVL 2 4.5 0.98775 -0.2603 0 0 0 0 0 0 0 9.19938 0 0 0 0 0 0 0 A0A8C0NX51 A0A8C0NX51_CANLF Uveal autoantigen with coiled-coil domains and ankyrin repeats Canis lupus familiaris (Dog) (Canis familiaris) AAQGHMDE;EQFRRDEGKLVEENK;ESLKNRFKYFEC;HQVKSLQQ;KQLEMEKLLLEN;LQLNEEVMVADDLESEK;LTSKNQVLQ;QENDKLKKEIFTLQK;VLATQMCRPAI 9 7.6 1.0022 -1.4477 0 8.075 0 0 0 0 0 10.943 10.476 0 0 0 9.46193 7.04199 0 A0A8C0NX53 A0A8C0NX53_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGYSGDDCGV;CQDGYAGEDCGEGEYAAF;GEDCGLRTCPSNCH;GSCPDDCNDQ;MPSSPPSASGSCPDDCNDQG;RDCRGRGRCENGV;TLCSLHGVFDLSRCACSCEP;VCDPGYAGDDCGSRSCPWDCGE;YEGADCGARSCPGGCHG 9 17.3 0.9736 0.048313 0 0 0 0 0 0 0 0 0 5.68378 0 0 0 0 0 A0A8C0NX55 A0A8C0NX55_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) DQAQVESALNLRAPGGRAEL;DTLSGRAASAPAGAPAAAPPA 2 7.8 0.99456 -0.1893 0 0 0 7.72717 0 0 0 0 10.4996 0 0 0 0 0 0 A0A8C0NX63 A0A8C0NX63_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GHSFLTEEEDVPSE;LVSETNNYRII;RVTVYEYDTRGDQWINIGTTL 3 7 0.99221 -0.14452 0 0 0 0 0 0 0 11.6685 0 0 10.7044 0 0 0 11.2574 A0A8C0NX79 A0A8C0NX79_CANLF Interferon induced transmembrane protein 10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AAPAPEPSASPPMAPTLFP;SFFLSSSLQAQ;TEVNDYYLWSIF 3 18.7 0.99693 -0.59744 0 0 9.32569 0 0 0 0 10.1763 0 12.444 8.86678 0 0 0 9.99605 A0A8C0NXB7 A0A8C0NXB7_CANLF Baculoviral IAP repeat containing 6 BIRC6 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of cytokinesis [GO:0032465] ubiquitin-protein transferase activity [GO:0004842] DESLLETCPIQSPLQ;DIQKTAEIVHAATTS;EEKYVAVMKKLQFVLV;EEMQHMDVEESQCL;LNIEVEQNGKPSLV;LNYVKDEDLAGCSTACA;LSLNSSSSGNK;NIPQIQVTL;PATSPISSNSHRS;SCPEDEALTPSDECMDGI;SLDRLYSRKIRKQLVHHKQQLNLLK;SLLAKVAA;TQEKPKDSDQ;TSQKEAMEVSLDIT;TSVGTLLA 15 4.4 0.96198 0.049233 0 0 9.32069 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NXD7 A0A8C0NXD7_CANLF Paired immunoglobulin-like type 2 receptor alpha PILRA Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] GAVLIIVILGLILYLRWKRSKGLQ;GLSLLLPLLLLLLPLL;LLLLLLPL;LLLLLPLL;LLLPLLLLL;LLLPLLLLLL;LSLLLPLLLLLLPLLP;SLLLPLLLLL;SLLLPLLLLLL;SLLLPLLLLLLPLL;SLLLPLLLLLLPLLPF;SLPLSVGAAVGAGAVLIIVILGLI;VLIIVILGLILYLRWKRSKGLQ 13 18.1 0.65106 0.33777 7.29994 0 5.21529 2.89887 0 0 0 0 7.14272 0 0 6.75636 6.49913 5.41187 0 A0A8C0NXD9 A0A8C0NXD9_CANLF SP100 nuclear antigen SP100 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ADGERDLSSRATIE;DTPSPLPCDGERAE;GLGPHRNTEKEPGNSNIC;IQMNSCSVYLVDIK;IRKKRRHIHKK;IRKKRRHIHKKNNLQKVRRRGRHR;NNFFDPYM;SNNFFDPYMRRIY;VQKVVYNVLNELEKTF 9 12.4 1.0039 -1.6785 0 0 0 4.91643 0 9.61228 8.82896 0 7.09117 0 7.24203 9.82271 0 0 0 A0A8C0NXG6 A0A8C0NXG6_CANLF Uncharacterized protein LOC106557878 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESWMCNGNTNKCHAQM;FSSCPESWMCNGNTNKC;KNMTQNTI 3 14 0.98712 -0.49892 9.95948 0 0 4.00243 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NXH9 A0A8C0NXH9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] TSVQAQPVASASP 1 5 0.99039 -0.21035 0 0 10.378 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NXI4 A0A8C0NXI4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGLLDAGKTHLQRQVR;PEAWLSSGPSPGP 2 7.6 0.91935 0.10899 0 0 0 0 0 0 0 0 9.36761 0 0 0 0 0 10.8453 A0A8C0NXK2 A0A8C0NXK2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RRVWGMSRFSLSASTLT 1 4.8 0.98509 0.046227 0 0 0 0 0 4.14657 0 0 0 0 0 0 0 0 0 A0A8C0NXP2 A0A8C0NXP2_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NSGTRGNINNKDT;TKEDKIYSETCSSVFKWICQ 2 14.2 0.91934 0.10988 0 0 7.46361 7.40233 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NXP5 A0A8C0NXP5_CANLF Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; platelet activation [GO:0030168]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229] plasma membrane [GO:0005886] alpha2-adrenergic receptor activity [GO:0004938]; epinephrine binding [GO:0051379] DADADADALDLEE;IEYNLKRTPRRIKAIIVTV;QPRRTQKPGSRRPP;SFFAPCLIMILVYVRIYQIAKRRT;VLAQTCAAAR 5 17.7 0.98519 -0.43097 11.4024 9.81221 0 0 6.68958 0 0 0 0 0 0 11.1851 0 6.81314 11.1476 A0A8C0NXP6 A0A8C0NXP6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;EEIKKKKKKKKEEIIPILLKL;KKKKKKKK;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 6 5 0.9749 0.047166 0 0 4.90198 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NXP9 A0A8C0NXP9_CANLF Transmembrane and coiled-coil domains 5B TMCO5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESETAKLEK;FKAQNNSSQIVKPG;QKSTESCTKQEKELFKIES;TLEVEEVLP 4 16.6 1.0029 -1.7195 7.96596 0 0 9.05723 0 0 0 6.62874 0 0 9.31143 0 0 0 10.6462 A0A8C0NXQ2 A0A8C0NXQ2_CANLF Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) RPSA Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]; plasma membrane [GO:0005886] laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; structural constituent of ribosome [GO:0003735] DIAIHCNNK 1 2.5 0.99485 -0.1898 0 0 0 0 0 10.5578 0 0 0 0 0 0 0 0 0 A0A8C0NXQ4 A0A8C0NXQ4_CANLF TGF-beta propeptide domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] EAGCGPQGV;TFFRASPGP;VRLPLRPCPPLLQAG 3 8.6 0.99232 -0.20742 0 0 0 0 0 0 10.738 0 0 11.7849 0 0 0 0 0 A0A8C0NXQ5 A0A8C0NXQ5_CANLF Cadherin domain-containing protein PCDH15 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; sensory perception of sound [GO:0007605] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; stereocilium [GO:0032420] calcium ion binding [GO:0005509] GVSEDARMFTS;PYLPRNLSVVEE;SEPVIVNIRVMD;SLGYTEGAL;VEENLPAGTTFLQ;VIISPADCSLELSPS;VLGSIHYVCLCTSC 7 4.8 0.93678 0.060938 0 0 0 0 0 0 0 0 10.3287 0 0 0 0 0 0 A0A8C0NXS0 A0A8C0NXS0_CANLF DNA ligase (EC 6.5.1.1) LIG3 Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; zinc ion binding [GO:0008270] GKRHWLKVKKDY;GLEGLVLK;MGCYDPSSQK;NPDDMARDLEQGDV;RGGAAGHL 5 5.8 1.0035 -2.0615 0 0 13.1001 12.2773 12.2942 12.4134 0 0 0 11.9983 12.065 0 7.52474 13.14 10.368 A0A8C0NXT1 A0A8C0NXT1_CANLF Adiponectin receptor 2 ADIPOR2 Canis lupus familiaris (Dog) (Canis familiaris) adiponectin-activated signaling pathway [GO:0033211] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023] LEINNTPERHQERW 1 2.5 0.9361 0.073874 0 0 0 0 0 0 0 0 0 0 0 0 9.44561 0 0 A0A8C0NXU6 A0A8C0NXU6_CANLF Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) CD40 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; regulation of immune response [GO:0050776] external side of plasma membrane [GO:0009897] signaling receptor activity [GO:0038023] DLEEFPMPPHSI;LRLKRVPKLPAQL;LVNDCLHTIDTE 3 9.7 0.99349 -0.27923 0 0 0 0 0 0 0 0 0 0 0 0 10.7235 0 11.3815 A0A8C0NXW2 A0A8C0NXW2_CANLF Checkpoint protein LOC119865601 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723] checkpoint clamp complex [GO:0030896]; nucleolus [GO:0005730]; site of double-strand break [GO:0035861] RAVCIRLGN;VEKMKNISNHLIME 2 8.8 0.99021 -0.26166 4.14127 0 0 0 0 0 0 0 0 0 8.44741 3.87735 4.96537 0 0 A0A8C0NY16 A0A8C0NY16_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SRPK2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mRNA processing [GO:0050684]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGECLRHPWLN;APQQKPIGKISKNKKKKLKK;DDEDDEEEDCPNPEEYNLDEPNAE;DEDDEEEDCPNPEEY;DFLIPMLEMVPE;GGGGGGGA;GGGGGGGG;GLGEAEGG;HSRQRGAGGAH;IGKISKNKKKKLKKKQ;IHVCMVFEVL;ISKNKKKKLKKK;ISKNKKKKLKKKQKR;KKLKKKQK;KKLKKKQKRQAELL;KNKKKKLKKKQK;KNKKKKLKKKQKRQAELLEKRLQEI;KPIGKISKNKKKKLKKK;KSIIRQVLQGL;LDDEDDEEEDC;NKKKKLKKKQKRQAELLEK;PTPPEPEEEILGS;QQLDDEDDEEEDC;RKGELRHI 24 15.6 1.0028 -2.4674 3.8846 5.66366 0 9.70848 8.40595 10.4339 7.07253 3.36008 11.1051 0 0 10.3006 0 9.9969 5.81435 A0A8C0NY31 A0A8C0NY31_CANLF U2 small nuclear RNA auxiliary factor 1 U2AF1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" membrane [GO:0016020]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628] AKSKKKKKKKKKKKI;AKSKKKKKKKKKKKIWIL;CLCYPVVGLKAKSKKKKKKKKKKKI;GGGGGGGG;GLKAKSKKKKKKKKKKK;GVLGLHFWHRE;HRERQVACLCYPVVG;KAKSKKKKKKKK;KAKSKKKKKKKKKKK;KAKSKKKKKKKKKKKI;KAKSKKKKKKKKKKKIWILIL;KKKIWILILEVLIPGAL;KKKKKKIWILIL;KKKKKKKIWILILEVLI;KKKKKKKK;KKKKKKKKIWI;KKKKKKKKIWILI;KKKKKKKKIWILIL;KKKKKKKKKIWI;KKKKKKKKKIWILI;KKKKKKKKKIWILIL;KKKKKKKKKIWILILEV;KKKKKKKKKKI;KKKKKKKKKKIWI;KKKKKKKKKKIWIL;KKKKKKKKKKIWILI;KKKKKKKKKKIWILIL;KKKKKKKKKKIWILILEV;KKKKKKKKKKK;KKKKKKKKKKKI;KKKKKKKKKKKIW;KKKKKKKKKKKIWI;KKKKKKKKKKKIWIL;KKKKKKKKKKKIWILI;KSKKKKKKKKKKKI;KSKKKKKKKKKKKIWI;KSKKKKKKKKKKKIWIL;KSKKKKKKKKKKKIWILI;LKAKSKKKKKK;LKAKSKKKKKKKKK;LKAKSKKKKKKKKKK;LKAKSKKKKKKKKKKKIWIL;LKAKSKKKKKKKKKKKIWILI;PVVGLKAKSKKKKKKKKK;PVVGLKAKSKKKKKKKKKKK;SKKKKKKKKK;SKKKKKKKKKK;SKKKKKKKKKKK;SKKKKKKKKKKKI;SKKKKKKKKKKKIWI;SKKKKKKKKKKKIWILI;VGLKAKSK;VGLKAKSKKK;VGLKAKSKKKKKKK;VGLKAKSKKKKKKKK;VGLKAKSKKKKKKKKK;VGLKAKSKKKKKKKKKK;VGLKAKSKKKKKKKKKKK;VGLKAKSKKKKKKKKKKKIWIL;VGLKAKSKKKKKKKKKKKIWILIL;VGNVYVKFRREED;VVGLKAKSKKKKKK;VVGLKAKSKKKKKKKKKKKI;YPVVGLKAKSKKKKKKK 64 16.6 1.0034 -2.2109 11.7507 9.33898 12.0752 9.32269 8.81176 8.4503 11.1231 11.4511 11.7779 9.62156 10.4589 11.6988 11.1813 11.8691 9.30968 A0A8C0NY33 A0A8C0NY33_CANLF Olfactory receptor OR5AN2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FFFSSLGLTECCLLAAMGYD;ISFLGCTTQYFF 2 9.6 0.99232 -0.18395 0 0 0 0 0 0 0 0 0 0 8.07275 9.9094 0 0 0 A0A8C0NY36 A0A8C0NY36_CANLF COMMD9 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EPAEGLLKRCCQTAVPR;LLTKIILEHVST 2 20.1 0.94477 0.10161 0 0 0 0 0 0 0 0 8.39541 0 0 0 0 4.7856 0 A0A8C0NY37 A0A8C0NY37_CANLF Cystatin fetuin-B-type domain-containing protein FETUB Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869] ATSVPMPVLPLPVL;ATSVPMPVLPLPVLSRD;FSNISKFFAYSLPK;HHPHGPPPHKHHPHG;IVIGQCKVIATKC;LDVLETDCHVL;PRVLEAAL;SVPMPVLPLPVL;TSVPMPVLPL;TSVPMPVLPLPVL;TSVPMPVLPLPVLS;TSVPMPVLPLPVLSR;TSVPMPVLPLPVLSRD;VFKNDFSNISKFFAYSLPK;VYRLPPLKKDEVLPLPEANF;YFVEYLIKESPCTKSQVS;YRLPPLKKDEVLPLPEANF 17 18.1 0 6.7787 11.2093 11.3014 11.3668 8.28309 0 0 13.8412 13.8429 13.779 0 0 0 11.4095 11.1085 11.497 A0A8C0NY38 A0A8C0NY38_CANLF Neurofibromin 1 NF1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AKLKRLLKETAFKFKALKKV;DTLEKCLA;EALLVLHQL;ESPPQYQTSYLQS;ETDYEMETQ;FTKEEHMRPFNDF;GVGCDVPSSGTTSQMSM;HGDPSYRTL;IHHGDPSYRTLKENQ;LDEEVLTDPKIQA;LFMNLLNDCSEVEDENAQTGG;LLVLHQLDSI;NMFSKEVELADSM;QELTVCSEDNVDVHD;VEQTIAIMKNLLDNHTEG;VGQTSPRARKS;VIALRRSC;WNPDAPVETFW;WQHVSFEVDPTRLE 19 8.5 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.11949 A0A8C0NY46 A0A8C0NY46_CANLF H15 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleosome [GO:0000786] DNA binding [GO:0003677] LHLRALWLQ 1 3 0.99226 -0.27195 0 0 0 0 0 0 0 11.2074 0 0 0 0 0 0 0 A0A8C0NY54 A0A8C0NY54_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVPSQSAGCPGAPLE;GVSRCALTVGGLSPV 2 2.3 0.99361 -0.1745 0 0 0 0 0 0 0 0 10.09 0 0 0 9.80315 0 0 A0A8C0NY57 A0A8C0NY57_CANLF Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) MED16 Canis lupus familiaris (Dog) (Canis familiaris) mediator complex [GO:0016592] ASTLQLDGLIRAP;FGKAPTLPTSASTL;PSQESLGR 3 3.7 1.002 -1.2546 0 0 7.29756 0 0 0 9.18626 0 0 7.41954 0 0 0 0 0 A0A8C0NY60 A0A8C0NY60_CANLF Uveal autoantigen with coiled-coil domains and ankyrin repeats Canis lupus familiaris (Dog) (Canis familiaris) EQFRRDEGKLVEENK;HQVKSLQQ;KQLEMEKLLLEN;LQLNEEVMVADDLESEK;LTSKNQVLQ;QENDKLKKEIFTLQK;SCSWFTCFKL;TRNQILSMMNCWFSC;VLATQMCRPAI 9 7.9 0.99993 -0.61146 8.70099 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NY61 A0A8C0NY61_CANLF "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Malate dehydrogenase [quinone] cytochrome b560 subunit)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; tricarboxylic acid cycle [GO:0006099]" "mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]" electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GEVPGTGAQDHSP;LVVGGEVPGTGA;SHLEWDPTFDMGPRERPEVWLECP;VGGEVPGTGAQDHSPCWKEL 4 19 0.99315 -0.021168 8.44493 7.98299 8.00023 0 0 0 0 7.6939 0 0 0 8.87689 0 0 10.7433 A0A8C0NY89 A0A8C0NY89_CANLF STEAP3 metalloreductase Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] endosome membrane [GO:0010008] LGLFIFFYVYNFVRDVL;LPGWKVPALLA;PQGGPRGRGGAGRGG 3 6.5 0.99451 -0.16395 10.5958 0 0 0 0 11.7137 0 0 0 7.84191 0 0 0 0 0 A0A8C0NYF3 A0A8C0NYF3_CANLF Syndecan CPQ Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813] cell surface [GO:0009986]; membrane [GO:0016020] EDHPKADERAELTSDKDMYLD;FLPSDQEQML;GVIGFLFAIFLILLLVYRMRKK;GVIGFLFAIFLILLLVYRMRKKD;SERKVDPSDE;SVRVRGFCRK;YPIDDDDYASASGSGADEDGES 7 31.1 0.99928 -0.61146 0 0 0 0 0 0 0 0 9.24558 0 0 0 0 0 0 A0A8C0NYF4 A0A8C0NYF4_CANLF Family with sequence similarity 217 member B Canis lupus familiaris (Dog) (Canis familiaris) FSSWDLRDL;KKGNRVNKSHQ;YADFLPAPFSSWD 3 6.2 1.0011 -0.62935 0 0 0 7.41945 0 0 0 0 0 13.316 12.2287 0 0 0 11.9185 A0A8C0NYG0 A0A8C0NYG0_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP11C Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] DKNREELFLRALCLCHTV;EMQKFLGSFFIS;GHMRIENQRKEIEEY;IENQRKEIEEYELLHTLN;LFPEILLIVLKNVRRRSARRNL;LLIVLKNVRRRSARRNL;VTSGLPLF;VVEVQADETFP 8 9 0.99578 -0.57006 0 0 0 0 0 11.1962 6.89833 8.1471 5.45292 0 0 7.72867 0 10.2709 0 A0A8C0NYG3 A0A8C0NYG3_CANLF DNA-directed RNA polymerase (EC 2.7.7.6) Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] CLRTGHLPLAHHVLVTHHSRARQQQ;GRLQIERRLRELSNFPQEF;PGSAPAPGSAP;PHPAFTELLAAAAEHTLIFEAAEV;TQVAAPHLPRQYW;VEMATTVPVE;VLHHLPGPAAPAPPLG;VTPPDLGGPGPVPPS 8 8.5 0.99133 -0.5455 0 6.18456 9.43459 7.77676 10.4847 8.02542 0 0 10.5958 0 0 0 0 8.78034 9.8923 A0A8C0NYL7 A0A8C0NYL7_CANLF Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) SCNN1B Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] apical plasma membrane [GO:0016324]; cytoplasmic vesicle membrane [GO:0030659]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280] GDGGLGCGCP;LKKYLLKGLHRLQ;RYCNNREFPDWAYCYSH;VLSQERDQSTNITLS;WITIIKLVAFAKSLR;WNYTPLVLI 6 11.2 1.0026 -1.3493 8.1152 3.99539 5.91803 9.41473 0 0 0 7.3336 0 0 0 0 0 0 4.93097 A0A8C0NYL9 A0A8C0NYL9_CANLF Phosducin-like protein 3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; positive regulation of gene expression [GO:0010628] endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471] protein folding chaperone [GO:0044183]; vascular endothelial growth factor receptor 2 binding [GO:0043184] VVDFALIV 1 2.6 1.0039 -1.1044 0 0 0 0 0 0 0 0 5.4914 0 0 0 0 0 0 A0A8C0NYM1 A0A8C0NYM1_CANLF "Mucin 13, cell surface associated" Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] NSYHNSYHHTNSYHQTNSYHHT;SLNSTYFCLCFFG;WSCIFVFNVV;YHQTNSYHHINSDHHINSYHQTN 4 10.9 0.99442 -0.15654 0 11.8141 0 0 0 0 0 0 4.45516 0 6.50613 0 10.0917 4.29946 0 A0A8C0NYN5 A0A8C0NYN5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PEDEADYYCSMHDVSGSSY 1 15.1 0.95403 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 4.71655 0 A0A8C0NYP8 A0A8C0NYP8_CANLF "Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" LOC606856 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LRLIILIRVFH;LRVYVEGLTILFRPLRLIILI;MVAFTKEVDEW;PPLYDDVKVQFFSSSDL;TILFRPLRLIILIRV;VISEIPALSE 6 10.2 0.97478 0.047166 0 5.94465 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NYQ1 A0A8C0NYQ1_CANLF Olfactory receptor OR2B8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVVSLFYGTAIYAYLQPSNNYSQ 1 7.3 0.97591 0.046449 0 0 0 0 0 0 0 0 0 0 0 0 7.7322 0 0 A0A8C0NYR6 A0A8C0NYR6_CANLF Nucleoporin 88 NUP88 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] DEPCDSDFSC;EPCDSDFSC;ILYENGETFL;SGMLYHCVVLEG 4 4.7 1.0018 -1.8045 0 0 0 0 10.3784 0 0 0 5.70213 0 0 0 0 0 0 A0A8C0NYS3 A0A8C0NYS3_CANLF Keratin 4 KRT4 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] RSACCARSRSWGR;SAVSICEYFASLPC;SDTNVVLS 3 5.5 1.0014 -0.70098 0 0 0 0 0 0 0 0 0 12.909 0 0 0 0 12.2831 A0A8C0NYS7 A0A8C0NYS7_CANLF Protein-tyrosine-phosphatase Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] HEVPRHVPAGCPHVDQ;VSGLSQITSSLYISNGVAANNKLM 2 33.9 0.93638 0.091998 7.76467 7.53123 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NYT7 A0A8C0NYT7_CANLF ENT domain-containing protein EMSY Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] EDPQSYTDSSSSSTESSQSSQ;GVLIKPKPV;GVPTTGQFMRIQNV;IVSGTTTKITTIP;RLVPQTAF;SIEGRRLV;SLVGAPTQILAQFP;VVVAGMANSTPQQQKCRESCSSPS 8 8.9 1.0046 -0.80421 0 0 0 0 0 0 0 3.37365 0 0 0 0 0 0 0 A0A8C0NYT9 A0A8C0NYT9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LNGLNLHGYP;VIWYQQLL 2 13.4 1.0027 -0.84567 8.68356 12.7236 0 0 0 0 0 0 0 0 0 0 0 9.35933 8.42752 A0A8C0NYU1 A0A8C0NYU1_CANLF CCHC-type domain-containing protein ZCCHC14 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] GCVVCTSCGCSGSCGS;GGGHSGGK;PIKLLVSSSVPA;PRTEAPVSSVSNSL;QGDTLTELYSLW;SSSGGGGG;TSCGCSGSCGSSG;VEIHLEGS;VGSSNGTG 9 8 1.0041 -1.0539 0 2.7148 9.67765 0 9.09165 0 0 0 0 10.5681 0 0 0 0 0 A0A8C0NYU2 A0A8C0NYU2_CANLF Myosin IXB Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; Rho protein signal transduction [GO:0007266] myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] DERNYHVFYYLL;DVLKVTTCVEMLIKEQ;ERNYHVFYYLLLGVSE;GKFIQVNYLE;LSQLLKVKREILVEVLTKRKT;MAVLREAGQLRAERAEKAA;PWKEYWGPSGV;QLDGTKCYVL;SQSRASCRVTATKDS;YHVFYYLL 10 5.2 0.98712 -0.23383 0 0 0 0 0 0 0 9.74749 0 0 0 0 0 0 0 A0A8C0NYU4 A0A8C0NYU4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TREEIEALIKNLPRHK 5 8.2 0.96134 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 4.38135 0 A0A8C0NYU8 A0A8C0NYU8_CANLF EWS RNA binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] GPGGMQGGRGGLMDCSG;HQSYGTYGQPTDVS;TAPARPQEGNKPAETSQ 3 8.3 0.99427 -0.023743 8.9021 0 0 0 0 0 0 0 0 0 8.70905 0 0 0 7.51657 A0A8C0NYV0 A0A8C0NYV0_CANLF Fumarate lyase N-terminal domain-containing protein ADSL Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189] "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]" AAEKEKQLRHDVMAHVH;DSANRRICLAEAFLTADAILNTL;EMCFMFSD;GLPITDEQIQEMKSNLDNID 4 16 1.0018 -0.67403 0 0 0 0 8.43621 7.69042 0 0 0 0 0 0 0 0 0 A0A8C0NYV1 A0A8C0NYV1_CANLF Tetratricopeptide repeat protein 27 TTC27 Canis lupus familiaris (Dog) (Canis familiaris) DAFSHCEF;KPILLLLARVILVNVRHKL;LDLRDKYKDVQVLKILVRAVV;MWTPELAVLRGF;VICYERAGQHGK;VLNEIKLADFEQFQ 6 10.9 1.0028 -1.8885 0 0 0 0 0 0 10.3066 0 0 0 4.72825 7.80187 6.06182 0 0 A0A8C0NYW0 A0A8C0NYW0_CANLF 40S ribosomal protein S3a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] TRSSQGRVLFFFFF 1 7.4 0.94272 0.0611 0 0 0 0 0 7.38275 0 0 0 0 0 0 0 0 0 A0A8C0NYX0 A0A8C0NYX0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] AASSYLSLTPDK;ASSYLSLTPDK;CTGSWAQSVLTQPASVSGS;GSPVTQGVETTK;GSPVTQGVETTKPSK;GSPVTQGVETTKPSKQ;GVETTKPSKQSNNKYAASSY;GVTVAWKADGSPVT;KADGSPVTQGVE;KADGSPVTQGVET;KADGSPVTQGVETTK;KADGSPVTQGVETTKPS;KADGSPVTQGVETTKPSKQ;KADGSPVTQGVETTKPSKQS;KYAASSYLSLTPDK;NKYAASSY;NKYAASSYL;NKYAASSYLSLTPDK;NNKYAASSY;NNKYAASSYL;PVTQGVETTKPSKQSNNKYAASSY;QSNNKYAASSYLSLTPDK;SNNKYAASSY;SNNKYAASSYL;SNNKYAASSYLSLTPDK;SPVTQGVETTK;SPVTQGVETTKPS;SPVTQGVETTKPSK;SPVTQGVETTKPSKQ;SPVTQGVETTKPSKQS;SPVTQGVETTKPSKQSN;SPVTQGVETTKPSKQSNNKYAASSY;SSYLSLTPDK;STVEKKVAPA;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ;SYLSLTPDK;TTKPSKQSNNKYAASSY;TTKPSKQSNNKYAASSYLSLTPDK;VETTKPSKQSNNKYAASSY;VETTKPSKQSNNKYAASSYL;YAASSYLSLTPDK;YLSLTPDK 47 32.6 0 30.627 12.4893 11.9683 12.8838 11.9043 11.9878 11.6637 7.37513 12.0722 11.0959 12.7039 11.9024 12.5855 10.107 11.3698 12.1469 A0A8C0NZ22 A0A8C0NZ22_CANLF "6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" PGD Canis lupus familiaris (Dog) (Canis familiaris) D-gluconate metabolic process [GO:0019521]; pentose-phosphate shunt [GO:0006098] NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616] GSAGLLWGSHLRTLS;MPGGDKEAWPHIK;RTLSQTRTVYP;VGSGEPCCDWVGDEGA 4 9.1 0.99075 -0.19608 0 12.7846 9.60281 0 0 4.55802 10.5119 4.99232 0 0 0 0 0 0 0 A0A8C0NZ31 A0A8C0NZ31_CANLF NPC intracellular cholesterol transporter 1 NPC1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol transport [GO:0030301] membrane [GO:0016020] lipid transporter activity [GO:0005319] ESGPTALFFAAQQGHND;FLLMFFGAFFAVWCYRKRYFVSE;IIDDTIFN;QASESCLFRFFKNSYSPF;SLSMPDDSYMMD;VALLLEAGAD;VAPSMFLS;YYVGESFANAMYN 8 7.5 1.003 -2.1616 10.4569 0 0 8.08273 0 0 9.69021 0 10.6493 10.1644 0 0 0 11.0244 0 A0A8C0NZ36 A0A8C0NZ36_CANLF Homeobox domain-containing protein MEOX2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; somite development [GO:0061053] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAACAPGD;ISAGVFSRLPSL 2 5.9 1.0025 -1.1996 0 0 0 0 0 0 0 0 0 10.0374 0 0 0 0 0 A0A8C0NZ43 A0A8C0NZ43_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MMFWAAPRPSHHNFPEGPSTVFWVA 1 9.6 0.99077 -0.29663 0 0 0 0 0 0 0 0 0 0 0 0 0 12.4163 0 A0A8C0NZ44 A0A8C0NZ44_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; sulfate assimilation [GO:0000103] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; sulfate adenylyltransferase (ATP) activity [GO:0004781] VLSMAPWPDLRGNH 1 2.2 0.9369 0.060957 0 0 0 0 0 0 0 0 0 0 5.01623 0 0 0 0 A0A8C0NZ60 A0A8C0NZ60_CANLF C3H1-type domain-containing protein TOE1 Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] Cajal body [GO:0015030]; cytoplasm [GO:0005737] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; snRNA binding [GO:0017069] HPVPGDGL 1 1.7 1.0047 -1.1044 0 0 0 0 0 7.72819 0 0 0 0 0 0 0 0 0 A0A8C0NZ62 A0A8C0NZ62_CANLF "Mucin 4, cell surface associated" Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] AWMFGDPHITTLDG;GCEACPPHLTALAPGLHC;LFHYGMTW;LPAEYRGRTEGLL 4 4.8 0.98774 -0.23422 0 0 0 0 0 0 0 0 0 0 0 0 10.0837 0 0 A0A8C0NZ64 A0A8C0NZ64_CANLF HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-protein transferase activity [GO:0004842] AGRHGQLAEAGRNVMVPAAAP;DEEAEMEEQAERN;EDELLFLMDWHL;EDVAVGAEHTL;EQYAYEKP;ESEDREEVVVC;GVSRWPVHDFNHRTTSDMWLYRAYS;GYGLASTGVTSG;HCLALSHDNEVYAWGNNSMGQCG;ISGCWRCL;LCQIVNSLLLLPVSVARPLL;LLSVSGSSCSLA;LVSMKWDPTGHILMTCAKEENVK;PLDSFIGQSADGK;PYSSQLVMAER;SLPGKGSK;SNSEGQLGLGHTNHVREPTL;SPVVHEDVEMRAALQFL;VGVSRWPVHDFNHRTTSDMWLYR;VIDELQKRKEEGQ;VLSQLCGTDTMLGQPLQ;YSKLVSNK 22 6.4 0.99956 -2.892 6.5051 0 8.85658 6.8031 0 13.0252 6.9982 7.84317 11.7675 10.9564 12.4451 11.2231 10.0046 12.7295 12.5308 A0A8C0NZ71 A0A8C0NZ71_CANLF Membrane spanning 4-domains A13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TTIELSSFNSVSY 1 8.5 0.94003 0.059589 0 0 0 0 0 0 0 0 0 0 0 0 8.95989 0 0 A0A8C0NZ79 A0A8C0NZ79_CANLF Enhancer of polycomb homolog 1 EPC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267] EAESNIAYYESIYPGEFKMPKQL;NSNSSTTTAQNLASNQQ;PKVLPSSAAA;QQQLALMQ 4 7.3 1.0033 -0.89286 0 0 0 0 0 9.29198 0 0 0 0 0 0 6.70473 0 0 A0A8C0NZ97 A0A8C0NZ97_CANLF PLAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AFEKANVD;ASKDIFQLEAQDVGE;DEEDEEDEEEESSSEESSSEE;DLLASFDPMDMPRGNKYEVRVYT;DVATVTGPMAAYVQEGP;EDEEEESSSEESSSEEEEEET;EEARKKKEKE;EEESSSEESSSEEEEEETE;GVFDRGRMDIFHIEL;KAKLQRKKKK;KKERLKAKLQRKKKKKK;LLKKERLKAKLQRKKKKKK;MPRGNKYEVRVYTG;MTVWTGDVVGGGT;NEIVREMTAEG;NNEITYYFPCQ;QLLKKERLKAKLQRKKKKK;RKKKKKKG;SSSEESSSEEEEEETEE;TDADVFINIFGEYG;VIEEYKFEAHRW;VLPSEDEEGGGGG;VPAGRPGP;VVGGGTDSNIFMTLY 24 10.3 1.0045 -1.1044 0 3.80405 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NZA7 A0A8C0NZA7_CANLF Keratin 76 KRT76 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EMSHVSDTSVVLSMDNNRCLDLDS;EQRGEMALKDAN;GASGGACGF;GVGGFGSRSLYSLGG;ISVAGGSR;QVKTQEREQIKTL;TELQAKVDSLTDELNF 7 15 0.93576 0.091743 0 8.02746 0 0 0 0 0 0 0 8.20858 0 0 0 0 0 A0A8C0NZC0 A0A8C0NZC0_CANLF Paired immunoglobulin-like type 2 receptor beta PILRA Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] LLLPLLLLL;LLLPLLLLLL;LLLPLLLLLLLTTLQ;QQHIPPFPRRAP;SLLLPLLLLL;SLLLPLLLLLL;SLPLSVGAAVGAGAVLIIVILGLI 7 18.2 0.94732 0.05044 0 0 0 7.68412 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NZC2 A0A8C0NZC2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] AGYKINAQKSVAFLYTNSETEEREI;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RIARGILKKKAVVIKTV 5 6 0.94365 0.081765 9.66835 0 0 5.87221 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NZD8 A0A8C0NZD8_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVQVVFSAFIIIKKK;RKNKTLIFKYFLNPINGAFLVL 2 14.9 0.99212 -0.27042 0 0 0 0 0 0 0 0 0 0 10.5032 0 0 0 0 A0A8C0NZE6 A0A8C0NZE6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NDVGWYQQLPGI 1 8.9 0.94701 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 8.18478 0 0 A0A8C0NZE7 A0A8C0NZE7_CANLF protein-lysine 6-oxidase (EC 1.4.3.13) LOXL4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] "copper ion binding [GO:0005507]; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [GO:0016641]" ACPGGMHA;DIGVVCHP;FFFFLAFFFFMIVTKRERERERERQ;LLLLLLLL;LSQLLLLLLLLQ;PSLEGSQN;SSLDQCMSNGWGVSDCSHSED 7 9.5 0.99937 -2.9204 0 7.75616 0 0 0 0 0 7.21762 0 0 0 0 8.4216 8.76616 11.3567 A0A8C0NZF7 A0A8C0NZF7_CANLF Transmembrane channel-like protein TMC5 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] KTLKVIGSKFGTS;LYSLFRLVERYEMPR;VACCVAVYYLAENN;VLELIYAQTLVWIGTFFCPLLP;YTDSPDTL 5 7.7 1.0031 -1.9464 0 0 8.91471 0 0 0 10.0388 0 0 0 9.46381 0 4.76011 0 0 A0A8C0NZH5 A0A8C0NZH5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAGAMRPLAAPPS;EDPMAKKGPQPYSSPH;EPAGASRAGESGSGQ;EQPRRAPPPTMTRDLQ;GGALAASSPMAC;GYSVSRAGQP;MLDICAEPSRTARAEPAG;PDLCCGPA;PEAQAGVQ;PTMTRDLQ;QAEKGGGQRRGRAPTD;QLLVARAAGREEGADTQSP;SRPTKATGSGAQAVEPP;TFFHPATRPQ;TMPENRAQPPLPGEAAPP;VGADSLEPKPPRNPPYTIHASP 16 5.8 0.99723 -3.8169 9.69973 9.21839 9.28647 8.83826 9.35764 8.73278 0 0 0 0 11.2993 9.38526 0 9.31757 10.7997 A0A8C0NZJ5 A0A8C0NZJ5_CANLF RIMS binding protein 2 RIMBP2 Canis lupus familiaris (Dog) (Canis familiaris) DEAWEQGRAPA;EAWEQGRAPAPVHGHMLEPPSLQ;EMSSKKKKGLLSRGKKLLKK;EVAEEGEH;FLEPPEHP;KGVTVRTLSA;KKKGLLSRGKKLLKKL;LPTNSNYSHVIFLNEEE;RCRFESDMDNER;SPNIDVEAELTF;TAGKYLYVYGDMDEDGFY;VPSIDEYSERDHLSPDFYEESETD 12 11.8 1.0025 -1.3494 0 0 0 10.4044 3.87706 0 10.903 0 7.76401 10.0819 0 9.32459 4.53717 8.84361 13.7277 A0A8C0NZJ6 A0A8C0NZJ6_CANLF cholesterol 25-monooxygenase (EC 1.14.99.38) CH25H Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789] C-4 methylsterol oxidase activity [GO:0000254]; iron ion binding [GO:0005506]; steroid hydroxylase activity [GO:0008395] LLDLLCPRVRALRRY 1 5.6 0.95654 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 4.57434 0 A0A8C0NZK2 A0A8C0NZK2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLHFFFFLFFIL 1 10.9 0.94607 0.05044 0 0 0 0 0 5.87056 0 0 0 0 0 0 0 0 0 A0A8C0NZN8 A0A8C0NZN8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLRLLLVLLLVLLLVLL;GLRLLLVLLLVLLLVLLL;LLFEEPLG;LLLVLLLVLLLVLLL;LLLVLLLVLLLVLLLVRH;LLLVLLLVLLLVLLLVRHG;LLVLLLVLLLVLLLVLLLVRHG;LLVLLLVLLLVLLLVR;LRLLLVLLLVLLLVL;LRLLLVLLLVLLLVLLL;LRLLLVLLLVLLLVLLLV;LVLLLVLLLVLLL;LVLLLVLLLVLLLVLLL;LVLLLVLLLVLLLVLLLVRH;LVLLLVLLLVLLLVRH;PGLRLLLVLLLVLLLVLLLVL;PHPPGLRLLLVLLLVLLLVLL;RLLLVLLLVLLLV;RLLLVLLLVLLLVLLL;RLLLVLLLVLLLVLLLV;RLLLVLLLVLLLVLLLVLL;VGSQLSSCGPSLSP;VLLLVLLLVLL;VLLLVLLLVLLL;VLLLVLLLVLLLVLL;VLLLVLLLVLLLVLLL;VLLLVLLLVLLLVLLLV;VLLLVLLLVLLLVLLLVRH;VLLLVLLLVLLLVLLLVRHG;VLLLVLLLVLLLVLLLVRHGH;VLLLVLLLVLLLVR 31 19.3 1.0026 -0.76014 8.74618 8.18354 6.62583 5.98525 7.85842 0 8.53516 6.52388 8.5755 7.6858 5.56307 9.4385 0 8.83476 9.13091 A0A8C0NZP5 A0A8C0NZP5_CANLF PAN deadenylation complex subunit 3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289] P-body [GO:0000932]; PAN complex [GO:0031251] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) binding [GO:0008143]; protein kinase activity [GO:0004672] AAAVAVVAPPG;AVAVVAPPGVGGV;FYGEECQFLHE;ITSCYKAV;PPAAAVPP 5 4.2 1.0025 -1.8553 0 0 0 11.1987 11.0813 9.02173 11.9694 0 0 0 0 0 0 0 0 A0A8C0NZP8 A0A8C0NZP8_CANLF PB1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) COPII vesicle coating [GO:0048208] cytoplasm [GO:0005737] identical protein binding [GO:0042802] PAGPWRGAPG;RRELIELRNKVNRLLDS;VGCGGASG 3 6.5 1.0023 -1.3605 0 0 0 7.9421 0 0 0 9.42578 0 0 0 0 0 0 0 A0A8C0NZR5 A0A8C0NZR5_CANLF KIAA0753 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099] LRLVGHEAVGT;LSPHPIRI;SSLEADANPRDQ;VPARCREL 4 4.4 1.0025 -1.8547 0 4.39087 10.678 0 0 0 0 0 0 0 10.3983 0 0 10.7178 0 A0A8C0NZU3 A0A8C0NZU3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] FLNRCLEMDV;NEILVMRENKNPN;PVYQKKKKNKKKS;SKVSKREEENENYTKKSVGTPPPS;VGDELWVVMEY 5 14.9 0.99194 -0.29247 0 7.83719 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0NZY9 A0A8C0NZY9_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] AGGKFGGG;CGGGGYGS;GGGGGGGG;IAQKSKDEAEAL 4 6.9 1.0036 -1.1044 0 7.21306 8.1497 6.63311 0 0 6.52287 0 0 6.16696 0 0 0 8.74015 0 A0A8C0NZZ8 A0A8C0NZZ8_CANLF Transcription elongation factor A1 TCEA1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription elongation by RNA polymerase II [GO:0006368] nucleus [GO:0005634] hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ASPPAQAWEPSWGARTPREGAP;SILQCHGDCD;VGAHAPERAPGGEG 3 6.5 1.0037 -0.80318 8.27137 9.0935 0 0 0 0 0 0 0 0 0 7.11103 0 0 2.50838 A0A8C0P000 A0A8C0P000_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MDAFLESHKL;MNEKGEITTNT;NEIETRRTVEQINRTRSWFSERISK;PSICCLQETHFRQ 4 4.3 0.97949 0.035538 0 0 0 0 0 0 0 0 0 0 0 7.01525 0 0 0 A0A8C0P007 A0A8C0P007_CANLF Sushi domain-containing protein CD55 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of complement activation, classical pathway [GO:0045959]; T cell mediated immunity [GO:0002456]" extracellular space [GO:0005615]; plasma membrane [GO:0005886] GLVAGTVIVILIIIKIFWHYG;HVPGASTITTGLVA;IVILIIIK;LLLLLLLL;LLLLLLLLL;LLPLLLLLLLLLRP;NFKWSKPDEFCK;PLLLLLLLLL;PLLPLLLLLLLLL;PLLPLLLLLLLLLRPPAAR;PPPLLPLLLLLLLLLRPPAAR;RALTPPPPLLPLLLLLLLLLR;STTANVPGTKAT;VPNAQPIL 14 21.9 0.99302 -0.061202 0 0 0 9.64904 0 0 9.81689 0 5.0892 0 0 5.83038 4.03852 3.2718 0 A0A8C0P022 A0A8C0P022_CANLF Ral guanine nucleotide dissociation stimulator like 3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] DKAPSVVQRALQKHNV;ELLDFGVD;KEGARPTTTVSSP;LSLDPPGLR;SPRIRRRISLTKRLSAKL 5 8.9 1.0026 -1.3861 10.5475 10.3029 0 0 0 0 9.66887 11.4835 10.3568 0 0 0 11.2195 6.04131 0 A0A8C0P027 A0A8C0P027_CANLF Thyroid hormone receptor associated protein 3 THRAP3 Canis lupus familiaris (Dog) (Canis familiaris) LSSRSRSRSYSPAH;TAPGGAAY 2 2.4 0.99126 -0.51361 0 9.00576 0 8.78034 0 0 0 9.8276 0 0 0 0 0 0 0 A0A8C0P033 A0A8C0P033_CANLF GP-PDE domain-containing protein GDE1 Canis lupus familiaris (Dog) (Canis familiaris) ethanolamine metabolic process [GO:0006580]; N-acylethanolamine metabolic process [GO:0070291]; phospholipid metabolic process [GO:0006644] plasma membrane [GO:0005886] glycerophosphodiester phosphodiesterase activity [GO:0008889] IYKMRQTDQN;PPPPLCGAGPL 2 6.2 0.98772 -0.47754 0 0 0 0 0 0 10.7575 0 0 0 0 0 0 0 0 A0A8C0P037 A0A8C0P037_CANLF Peptidase S1 domain-containing protein TMPRSS12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DKAFEHFLV;DTCRVRTNDF;KIKVKAIIIHPGFNLET;PYSGHDWLSE;RTEEEGNITDVLQ;SERTGRRSWREQAG;VGSALPYSGHDWLSERT 7 25.6 1.0029 -1.5069 9.95971 8.57016 0 0 0 0 8.50851 9.7058 0 0 0 0 6.66647 0 9.53733 A0A8C0P051 A0A8C0P051_CANLF CD45-associated protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLLLLLLL;LLLLLLLLL;TVVLLLLLLL;VLLLLLLLL;VTVVLLLLLLLLLATGLALA;VVLLLLLLL;YHLVGGLEETESQEEDQQCRDG 7 20.3 1.0019 -1.3206 6.29162 0 0 0 0 0 5.4745 0 0 0 0 9.65887 0 5.60786 0 A0A8C0P057 A0A8C0P057_CANLF PX domain containing serine/threonine kinase like PXK Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of monoatomic ion transport [GO:0043271] plasma membrane [GO:0005886] ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein kinase activity [GO:0004672] LSLPLPPKKLI;VLSWADLGPDKYLSDK 2 5.6 0.93874 0.099984 0 0 0 0 0 7.05115 0 0 0 0 0 0 0 0 0 A0A8C0P061 A0A8C0P061_CANLF HSR domain-containing protein SP140 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" PSLFSNGQRVFHCVSI;SDEEEPQEALSSPP 2 8.6 0.99727 -0.10287 0 0 0 0 9.01229 9.40939 0 0 0 0 0 0 7.46964 7.41549 7.11489 A0A8C0P065 A0A8C0P065_CANLF CMP/dCMP-type deaminase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] GVQVDIMCFEDYKYCW;WRLGGHHPRSPMDRIGPE 2 16.9 0.93536 0.097546 0 0 3.61941 0 0 8.90788 0 0 0 0 0 8.92769 0 0 0 A0A8C0P066 A0A8C0P066_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADYYCQVWDSSAD;AEDEADYYCQVWDSSADAHSDTGR;GGDSIGSKNVYWYQQKP;GRWGNETRTLYTICVT;QVWDSSADAHSD 5 31.8 1.0013 -0.6433 0 0 11.4375 0 0 0 0 0 8.09138 9.02348 0 0 0 11.3032 0 A0A8C0P083 A0A8C0P083_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALSSCGVWRVLPAQ;LLLPLLLLL;VLLLLPLLLL;VLLLLPLLLLLRPG;VLLLLPLLLLLRPGN 5 8.3 0.99533 -0.011158 0 0 0 0 0 0 0 6.48412 0 0 0 0 0 0 7.51546 A0A8C0P092 A0A8C0P092_CANLF Cytospin-A Canis lupus familiaris (Dog) (Canis familiaris) FWSLAGRQC;GGAAGACA;NENRMLKDRLNALG;VEGSAPGS 4 3.2 1.0035 -0.83642 0 0 0 0 0 0 11.1752 10.0755 0 0 0 0 0 0 0 A0A8C0P0A2 A0A8C0P0A2_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) "autophagy [GO:0006914]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of autophagy [GO:0010506]" cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] INKGNWCYINAT;LSPNNEKLTISNGPKSHSV;LVPVSEDPV 3 5.3 1.0015 -0.70406 0 11.7655 0 0 0 6.54867 0 0 0 0 0 0 0 0 0 A0A8C0P0B5 A0A8C0P0B5_CANLF START domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; lipid binding [GO:0008289] AFTGLEEGRASPKQGTN;ATTTPSSADPESSGNFP;DKKMLHFDSSDINPYILSSH;EEYFPQAA;ELDQAHISRQIKDNQ;EMLLCSGSQVCVA;FGSALDVSCGQTPQG;FLKSPCHSNI;GEEQEVRLYYKMFSSTRHGFLGAGV;HPSVSFAFLSGP;IDHLTKDWTQKWNEWKA;KESSKAAL;LEPSKASCWLQ;LQELNLSVEPPSPTD;NIEEESHNSVYFF;PLLWKKRRVLEELS;PSSADPES;QEKLRIRQQIISQLLKEEE;QIRAKQDLELDQAH;QTEMLLCSGSQVCV;RHQADGPWEEEGQQRDQALSGS;SAASFTHVGSTHERD;SEPLRKFQGSSV;SLVQGVSSPSAPG;SVDYVLDP;TDDVTFRDSEAR;TEACQTEMLLCSGSQVCV;TETFWHLQTSSLPIVEQE;TLAMSNSLSTS;VGGPVGQSRINTLEQGTQTLGCSL;VGSTHERDWGALQ;VHDTVGISSV;YHVGDPDSTSSLTD 33 9.8 0.99672 -4.667 0 12.1808 8.41595 0 3.32207 8.6315 7.50708 12.3142 0 8.88966 10.3415 11.2337 11.3962 6.67002 0 A0A8C0P0B8 A0A8C0P0B8_CANLF PID domain-containing protein NOS1AP Canis lupus familiaris (Dog) (Canis familiaris) nitric-oxide synthase binding [GO:0050998] GVKVILKKKKKK;GVKVILKKKKKKKE;GVKVILKKKKKKKEW;GVKVILKKKKKKKEWTW;LVMQDPIYRIFYVSHDSQDLKIFSY;NGEVSLSVP;RNGLKLSLS;VILKKKKKKKEWTW;VKVILKKKKKK;VKVILKKKKKKK;VPRPNSRVEIV 11 15.8 1.0015 -0.69763 13.1917 4.32359 8.69209 10.7804 5.25901 10.7555 0 9.93066 5.78194 0 13.2011 0 13.446 0 0 A0A8C0P0B9 A0A8C0P0B9_CANLF VPS35 endosomal protein-sorting factor-like CCP110 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; protein transport [GO:0015031] endosome [GO:0005768] CKCIMEVFIKHQQE;CSSKVCVTKNTSEAIQ;IQFYPSKFVLITDILDTFG;LDVETRKHVNRKKALLTRV;LEKKVIHGLAIVEGQ;NRIEELNQSL;PSLSEEVTPDPYI;QERLQKEIEE;TQQDYVNRIEELN 9 6.4 1.0023 -1.0202 0 9.32202 11.8327 0 0 0 11.4761 0 7.98959 0 5.24664 0 10.0345 9.67145 0 A0A8C0P0C2 A0A8C0P0C2_CANLF Solute carrier family 6 member 15 SLC6A15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATLPLLIIVIL;GTGLAFIA 2 6 0.9848 0.035491 0 4.12474 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P0C5 A0A8C0P0C5_CANLF Aminotransferase class I/classII domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] FEMIINPGDNVLLNEPIYSGT;YIELSLFMKVFNE 2 8.4 0.91772 0.10966 0 6.02212 0 0 0 0 0 0 0 0 0 0 0 0 8.72601 A0A8C0P0D3 A0A8C0P0D3_CANLF Mannan binding lectin serine peptidase 1 MASP1 Canis lupus familiaris (Dog) (Canis familiaris) complement activation [GO:0006956]; innate immune response [GO:0045087]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ADCGAPAE;CDHYCHNYIGGYYCSCRFG;DKWFGSGALLSES;GVYTKVSNYVDWL;MPANSRDTQ;TFCGRETTDTEQ;VETEEQVLAT;VYTQRTGVITSP 8 13.6 0.90367 0.12181 0 0 0 0 0 0 0 0 0 0 0 0 10.4072 0 0 A0A8C0P0F0 A0A8C0P0F0_CANLF guanylate cyclase (EC 4.6.1.2) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] DIVHMNRE;KTCTILFSDVVTFTNIC;LQELEQRRMHLS;PGSVWPGKGEAQGSR;RLQDSQDFRRDQEALEAAFLRMK 5 9.1 0.98462 -0.24347 0 0 0 0 11.8444 0 0 8.61938 0 11.0731 0 10.5553 0 0 0 A0A8C0P0F7 A0A8C0P0F7_CANLF HMG box domain-containing protein BBX Canis lupus familiaris (Dog) (Canis familiaris) bone development [GO:0060348] nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837] CNDECSHNPETA;DESPEQRARRPMN;DTTKESRP;EQDVGETDDES;KELRNFEELRMDDIMDIKMEDSKEI;SEEEEEEDEEEDIDK;SETGCNDECSHN 7 8.9 1.0028 -2.1157 0 0 0 0 0 8.24041 0 0 10.3299 0 5.27038 0 6.71053 0 0 A0A8C0P0H3 A0A8C0P0H3_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DPENLNLVFSRRGKT;EESILWTKGEILGKGAYGTVY;SIWSRNMCSFWEANHHRPHME;SNEEFDQDEDCS;TVFEMATGKPP 5 6.6 0.95088 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 6.54394 0 A0A8C0P0J6 A0A8C0P0J6_CANLF SAM domain-containing protein PPFIA2 Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] cytoplasm [GO:0005737]; presynaptic active zone [GO:0048786] DLRKHRRKIAVVEEDGR;IKSSIGRLFGKKEK;KLTPRSPAREMDRMGV;LDEKIVALREQN;LDENFDYSSL;MNEEHNKRLSDT;RGFMETEAAAQESLGLG;SEGSTESEHLE;VSGSPKVHPPNGT 9 10.6 1.0032 -0.9753 8.83507 0 0 0 0 0 8.13181 0 11.0343 0 0 0 7.50748 0 8.03078 A0A8C0P0K1 A0A8C0P0K1_CANLF Family with sequence similarity 151 member B Canis lupus familiaris (Dog) (Canis familiaris) EDLLCIRDFF;FSLGWTTGWH;VKRHLKRPVWI 3 12.2 1.0026 -0.84536 0 0 0 0 0 0 10.1829 0 0 4.53107 6.05972 0 8.98507 0 0 A0A8C0P0L5 A0A8C0P0L5_CANLF Helicase ATP-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] CQFDEKSRDP;IVTSLVKQKEFDELVHWHS;KSISVSLRE;MMEEACET;MSSTYKKQTFFKENEKEI;QPNTPNHVVL;TTIKFYQSKVFLEDLPEDF 7 5.8 1.0032 -2.0798 0 0 8.99639 10.8801 0 7.84806 9.65259 0 0 0 0 0 10.0794 0 0 A0A8C0P0M9 A0A8C0P0M9_CANLF Syndecan CPQ Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813] cell surface [GO:0009986]; membrane [GO:0016020] GGGGGGGA;GGGGGGGG;GVIGFLFAIFLILLLVYRMRKK;GVIGFLFAIFLILLLVYRMRKKD;PRVAPEPR;SERKVDPSDE;YPIDDDDYASASGSGADEDGES 7 15.8 0.98487 -0.25935 0 11.6364 0 0 0 0 0 0 0 0 11.2666 0 0 0 0 A0A8C0P0N7 A0A8C0P0N7_CANLF C-X-C motif chemokine Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009]; growth factor activity [GO:0008083] AARLLLLLLLLLL;APRAPRPLGAARLLLLLLLLL;ARLLLLLLLLLLLGPA;GAARLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LVKRMIQKMLKQLV;PLGAARLLLLLLLLLLL;RLLLLLLL;RLLLLLLLL 12 31.7 0.99533 -0.01216 0 0 0 0 0 6.45268 0 0 0 0 0 0 8.59085 8.6536 6.32157 A0A8C0P0N9 A0A8C0P0N9_CANLF Leucine rich repeat containing 37A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAPLTLTPEPTTK;EPFATQHEAP;FHKIRSRIVQRTPKTKKSKKFRK;GVQVTVTPEPTTE;NNKLILAISVTVVVMILIIV;STTLHQTTAPPKD 6 6.1 1.0026 -0.71961 0 0 0 0 8.39069 0 0 0 0 0 0 7.19918 0 0 0 A0A8C0P0R5 A0A8C0P0R5_CANLF Histone H2B Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] DLGFGSCS;EGGDQGAEEGRQE;EVLYERDQRHFAPTTLVFVF;GVAPGALQQALDHHVQ;RKRSRKESYSIYVYKVLKQ 5 21.9 1.0021 -1.2409 15.4486 7.56201 7.58429 0 0 0 0 0 0 15.5201 0 15.6217 0 15.6846 0 A0A8C0P0R8 A0A8C0P0R8_CANLF Protein kinase domain-containing protein CDK17 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] GVGCIFFEMASGRP;KPQNLLINEKGELKLADF;RMKKFKRRLSLTLR;TIEENSSKDNEPI 4 10.5 0.99547 -0.086423 8.63728 0 0 0 0 0 0 0 0 0 0 5.31012 0 0 10.1317 A0A8C0P0S5 A0A8C0P0S5_CANLF Cell cycle control protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YMYYKLYGFYQN 1 3.5 0.95331 0.05044 7.2879 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P0T3 A0A8C0P0T3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KLIKKILLL;LIKKILLLVTQISFLFP;SEKLIKKILLLV;SEKLIKKILLLVTQI 4 14.6 0.9875 -0.22526 0 0 0 0 0 0 5.46809 3.72203 0 0 0 0 0 3.29386 0 A0A8C0P0T7 A0A8C0P0T7_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" membrane [GO:0016020]; nucleus [GO:0005634] mRNA binding [GO:0003729] TADTDCTVWCCEIASLHQSCVL 1 6.2 0.97389 0.046862 0 0 0 0 0 0 0 5.62752 0 0 0 0 0 0 0 A0A8C0P0U3 A0A8C0P0U3_CANLF Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] AGARSPAPRDLSP;AQEEEPVYIEMVGDVFRGG;ARHRPDRGLCKQE;KGGFGAGG;LHTPRPCSQPRDAPSQT;PKDKAVSYTMVYSAVKVTTHSVLP;VGGVTEDGSARRPP;VPGCHRGAPLRAAPCFAP 8 12.9 1.0026 -1.4021 9.26245 9.54595 9.07919 8.38608 0 0 10.778 12.4044 0 0 9.8251 10.114 9.58203 9.66599 10.215 A0A8C0P0U6 A0A8C0P0U6_CANLF TSC22 domain family member 4 TSC22D4 SPACDR Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] PGSPGSSEPPALPGPTAP 1 4.6 0.99442 -0.12947 0 0 0 0 0 0 11.3629 0 0 0 0 0 0 0 0 A0A8C0P0V2 A0A8C0P0V2_CANLF NACHT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EIQDLNKHILE;EIRHHLGLSTEATW;LVLSASKDHTLRLWNLLSG;QEVLGSMNWISCRG;QEVLGSMNWISCRGV;QGKMVTGFSKGSISLVSPGGD;SLARRPVDGFTLLAIA;SPGDPCPVIDGPTYTF;TELLARLHFFA;TPFLDRTGLTAVS 10 8.8 0.95767 0.049233 0 0 0 0 0 8.14165 0 0 0 0 0 0 0 0 0 A0A8C0P0W0 A0A8C0P0W0_CANLF Piwi like RNA-mediated gene silencing 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] P granule [GO:0043186] piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521] PQWALYQYHIDYNPLMEARRL;VISPQGKKMTGRA 2 3.9 0.53371 0.44456 16.0371 15.7794 16.2115 0 0 11.2043 16.4446 0 16.6978 0 0 0 0 16.4623 0 A0A8C0P0W9 A0A8C0P0W9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;FKLNTKETNNPIMKWAKDM;MDAFLESHKL;MNEKGEITTNT;NNSERENKGREKKC 5 6.1 0.9413 0.061052 0 0 0 0 0 0 0 7.39583 0 0 0 0 0 0 0 A0A8C0P0X3 A0A8C0P0X3_CANLF Latent transforming growth factor beta binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DINECLEDNSVCQGGDC;GFNKCQKCPKKPSYHGYN;HGPGVAEPEV;INTEGSYDCTCPDGFQLND;ISEEKGPCYRLVSSGRQCMH;ISTIHLHPQFPEINECTVNP;PGAPSERTRRTSP;QPGYECYCKQ;SISADGHTCE;SLDQEKTKLEPGQPQL;TTYTECCCLYGEA 11 9.9 1.0034 -0.78879 0 6.78712 0 4.33885 10.0747 0 0 0 0 0 0 0 9.88794 10.3681 9.07004 A0A8C0P0X7 A0A8C0P0X7_CANLF BRI3 binding protein BRI3BP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] DVLGLDVSSLSQY;GVDMFVETL;PARALLLVGV;PPLLLLLL;PPLLLLLLL;RARARLPRPPPPLLLLLLLG;RARLPRPPPPLLLLLLLGLLAP 7 22.6 1.0032 -1.5627 9.73315 0 0 0 0 0 0 0 5.59959 0 0 0 5.84639 0 0 A0A8C0P0Y4 A0A8C0P0Y4_CANLF Beta/gamma crystallin 'Greek key' domain-containing protein CRYBG3 Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] AQENLTNDAFEDTE;DVEDITGKTV;EDERPGTSPPPAAGRGAASVE;EKPHFQGQKCVL;GGEEDEEEDEEEEEL;GVWVAYEKEH;IDSVPKFLKNN;KCQEENVANHIE;KEAELNIAKTEPTAD;PACLHLEHASAIFDSKQ;SEKGARFGG;SFTILYEEPLQDEDRYTTADVRR;SGNGAGQS;SSKEVLNKNDPG;TEKTEVMPTTLE;YQQKFFCGEQYILEK;YYQEDNSCNQC 17 7.7 1.0026 -1.8951 11.9843 5.24321 0 0 12.7936 0 0 0 10.1013 8.58774 0 8.37617 10.0673 0 0 A0A8C0P0Z6 A0A8C0P0Z6_CANLF Interleukin 18 receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] hydrolase activity [GO:0016787] IENINEKNLLFSY;VHEEDITRIRTL;VLSKSYMSNEVSS 3 7.6 0.93964 0.059615 0 0 0 0 0 0 0 0 0 0 7.10434 0 0 0 0 A0A8C0P0Z7 A0A8C0P0Z7_CANLF Myelin protein P0 (Myelin peripheral protein) (Myelin protein zero) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GVIGVVLLLLLLFYLI 1 6.4 0.96292 0.049233 0 0 0 0 0 0 0 4.1478 0 0 0 0 0 0 0 A0A8C0P113 A0A8C0P113_CANLF "Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein)" SLC25A3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial phosphate ion transmembrane transport [GO:1990547] mitochondrial inner membrane [GO:0005743] phosphate transmembrane transporter activity [GO:0005315]; symporter activity [GO:0015293] AAAVEEYSCEYGS;GVLSCGLT;GVRGLAKG 3 18.6 1.0031 -2.4857 0 0 0 0 0 0 9.6621 0 0 3.95921 0 0 12.5848 0 0 A0A8C0P118 A0A8C0P118_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HLRHLTELDVSCNEIQ;LVERTRREAQLAALQYE;QDNLCSPSDILQLNLSV;SLSSQFMAYIEQRRISHEGSP;VPVEPSSLMSLSPTHNQ 5 11 0.98803 -0.49584 0 8.9863 7.86053 8.95376 0 0 13.1815 0 0 0 0 0 0 0 0 A0A8C0P123 A0A8C0P123_CANLF Transforming growth factor alpha Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PGQGPGRGGLFNLQEPLKRPP;VLIHCCQVRKHCEWCQALLCRHEKP 2 20.4 0.94898 0.050031 0 0 7.8993 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P134 A0A8C0P134_CANLF Cyclin-like domain-containing protein CCNT2 Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of transcription by RNA polymerase II [GO:0006357]" cyclin/CDK positive transcription elongation factor complex [GO:0008024] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575] DELTHEFL;FYMHHSFTKFNRNIISP;LSSHQEWP;QIYSQKQETSLSGSQYNINFQQ;TLELLDELTHEFLQILE 5 9.9 1.0035 -1.0581 0 0 0 10.309 0 0 0 0 0 0 0 0 6.57581 0 7.54759 A0A8C0P136 A0A8C0P136_CANLF Glutamine and serine rich 1 QSER1 Canis lupus familiaris (Dog) (Canis familiaris) CKDEISSVQKRNEDLGQEEIVQ;ETSRQSSLSCSPIG;LDVAHVTSDF;SNGILNPHDP;STHCQTLQN;SVSVNPTRSALALLAMAQPGEAT;SYLSNASVVNFQETS;SYMELLVSIALDPDTMQAL;TNENYPSQTRDL;VLLDSACDLQ 10 8.1 1.0029 -2.1621 9.01109 10.8182 9.80901 0 0 0 12.1923 7.42534 7.87823 0 0 0 0 13.2441 0 A0A8C0P151 A0A8C0P151_CANLF FAM161 centrosomal protein B FAM161B Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] HGDVATTAKAQVPKQKATRRIPRSI;LEGFFQDKGRGKPQ;QGQEEAECYRQFRA;SFDSTGSFSETLEALKQ;TTAKAQVPKQKATRRIP;VEASGGAQWSRQ 6 13.8 1.0032 -1.1207 0 0 0 0 0 0 0 0 11.0141 9.51796 9.90147 0 0 9.311 0 A0A8C0P155 A0A8C0P155_CANLF G-protein coupled receptors family 1 profile domain-containing protein OPN3 Canis lupus familiaris (Dog) (Canis familiaris) phototransduction [GO:0007602] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881] ESGAGGASKTVDAPAG;NAARGGGG;RKGRGRAGP;VGNNLLVL;VSLFGVTFTFVSCL 5 9.4 1.0032 -2.2833 0 0 11.3246 7.78973 7.05582 0 0 0 7.69488 0 9.1146 0 8.31483 11.6448 0 A0A8C0P160 A0A8C0P160_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EGGPHVCVPERVGVGEGKLGHR;GVGDGPAEAAETFPA 2 6.2 0.97383 0.046699 0 0 0 0 0 0 0 0 9.53037 0 0 0 0 0 0 A0A8C0P164 A0A8C0P164_CANLF SMC hinge domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromosome condensation [GO:0030261] chromosome [GO:0005694]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DELRIKENELQS;GVNANNSRVQDLFCSV;IEAMAVEVAKNKESVNKAQ;TLELEELKREHTSY;VTRQVVIGGRNKYLINGVNANN 5 6.6 0.8631 0.18293 0 7.16491 9.63791 5.51661 0 0 0 0 0 0 0 0 8.93608 9.38094 0 A0A8C0P166 A0A8C0P166_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] AGEVGEDSRHTGPPVLPRP;AIDGAGEEADFHQASADFRRENVLP;ALPALPAVQVPRGRG;ALPAVQVPRGR;EDAFNQIMGYSRKDL;EQEQDQASSETEPSDPAPT;IDSDEEEHEFQQGL;PDAEQVARGAEP;QEQEQEQEQEQEQDQ;SDADLVMLLSLFEEE;TDVLEIEIKDK;VMVKGMEGGASGNQHSRKLVSF;VTFVGEEGLDYSGP 13 13.3 1.0022 -1.3714 10.4147 10.1619 0 7.03991 6.32034 7.8874 10.6241 11.6899 11.6973 11.4042 6.77992 11.5437 11.3104 0 0 A0A8C0P182 A0A8C0P182_CANLF DNA helicase (EC 3.6.4.12) CHD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] DQRSPYGSRSPFEHSIEHKSTPE;EDDEEDYDN;EERQKELEEIYMLP;ERKRPKKRGRPRTI;EYYNCQQE;FTEFDARK;GAEFWKSSPSILAV;HLIRSSGKLILLDKLLIRLRERGN;MSALQKQYYKW;RKARAKKNKAMK;RNSKNWEEIIPED;SEEEDDEEDYDNDK;SSEEEDDEEDYDND;TISFLNYLFHEH 14 9.9 1.0032 -2.0984 0 0 9.12438 8.95818 5.05719 0 0 9.49099 0 0 7.62914 9.01436 4.66443 8.42127 0 A0A8C0P185 A0A8C0P185_CANLF Flavin-containing monooxygenase (EC 1.-.-.-) LOC478994 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" DIFFGPCTPYQYRLQ;LFVLTLIIIK 2 4.7 0.99439 -0.55758 0 0 0 0 6.59101 0 0 0 0 0 0 4.09828 0 0 0 A0A8C0P1B8 A0A8C0P1B8_CANLF Ankyrin repeat domain-containing protein 26 Canis lupus familiaris (Dog) (Canis familiaris) CATIVLGQGADPNIKDDEGNT;DLQLAHSNVVKQM;PHAAPAPA;SKLSFHENDNQPGEHVFNKN;VPQAFPERKEPSLENAVLSHSYSGS;YFGLNGSNERDKRN;YHIESQDLRKIHKAAITGNVKKVE 7 8.4 0.99146 -0.20599 0 0 0 0 5.22184 0 0 0 12.8738 9.5266 0 0 0 10.0137 0 A0A8C0P1F0 A0A8C0P1F0_CANLF "Actin, aortic smooth muscle (Alpha-actin-2)" ACTG2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] DLYANNVL;FERSVYSDRYIFAKNLFEN;GDDAPRAVFPSIVG;IMFETFNVPAMYV;LTEAPLNPK;NLLDMMYQEPARW;TALAPSTMKIKA;TEAPLNPK;VLDSGDGVTHNVPIYEGYAL;VQIFERSVYS 10 19.7 1.003 -1.7154 7.94017 0 0 10.4001 0 0 0 0 8.66973 0 8.46025 0 0 0 0 A0A8C0P1F6 A0A8C0P1F6_CANLF Protein inhibitor of activated STAT 2 PIAS2 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of macromolecule metabolic process [GO:0060255] nucleus [GO:0005634] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] PDAVMWKV 1 1.2 0.98502 -0.25869 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2617 0 A0A8C0P1F8 A0A8C0P1F8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLALLGSPGGP 1 10.4 0.98125 0.035491 0 0 0 0 4.79275 0 0 0 0 0 6.25187 0 0 0 0 A0A8C0P1H1 A0A8C0P1H1_CANLF BTB domain-containing protein KCTD14 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] GYQVYYEQYSERT;QACPAPGP;SEEDAALCADALRILEGEKRSVVKF;SPKACTDAEGRLFI 4 24.5 0.99722 -0.59709 0 0 0 0 0 0 0 0 0 0 0 8.55175 0 0 0 A0A8C0P1J1 A0A8C0P1J1_CANLF Nucleoside diphosphate kinase (EC 2.7.4.6) Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] SLYLTPPSFSSYP 1 5.3 0.87485 0.12681 0 0 12.2198 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P1K5 A0A8C0P1K5_CANLF Aminotransferase class I/classII domain-containing protein SPTLC3 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] membrane [GO:0016020] acyltransferase activity [GO:0016746]; pyridoxal phosphate binding [GO:0030170] AAIEREEQ;ESPVIPLLLYMPA;IEREEQKDFVPLYQ;NFENFYTRNLYIRIRDNWNRPIC;TFMITFYLSL;TYLGYGLGTLFGYLRDF 6 13.2 1.0027 -0.79239 0 0 0 0 0 0 8.09714 10.1683 0 0 8.88972 0 7.27454 0 0 A0A8C0P1L0 A0A8C0P1L0_CANLF Radial spoke head component 1 RSPH1 Canis lupus familiaris (Dog) (Canis familiaris) DDYRYDTTDQGIVSFEEEESKQSEL;EYRLTDVERGEE 2 13.4 0.94028 0.085978 0 6.95977 0 0 9.58016 0 0 0 0 0 0 0 0 0 0 A0A8C0P1L4 A0A8C0P1L4_CANLF PWI domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] DKKHKKHKKHKKEKAM;VGRRRKHSP 2 3.8 1.0028 -0.75498 0 0 0 0 0 6.03049 0 0 0 0 0 0 0 8.58556 0 A0A8C0P1M0 A0A8C0P1M0_CANLF Zinc finger matrin-type 1 ZMAT1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] DGGGGFGGS;HQKRRRHLEKGEEKP;ICGVVLQFESQRISHYE;KHRKKKKSHGVP;PEKPVPLSLSQQEN;QRISHYESEKHAQNVRFYFQMHG;QSHYVGKVHAKKLK;SEVVDRNKFCDLC 8 15.8 1.0041 -2.0229 10.8277 0 0 0 0 0 0 0 0 9.31771 2.71451 0 9.0713 7.2268 10.6521 A0A8C0P1N0 A0A8C0P1N0_CANLF Beta-arrestin-1 (Arrestin beta-1) ARRB1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968]; protein transport [GO:0015031]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] DIVFEDFAR;KKPLTRLQERLIKKL;LLPGEGKG;VGEVEVISTQAQEWERVGH 4 10.2 1.0012 -0.94227 8.06048 0 0 0 9.79019 10.197 0 11.6307 0 0 0 5.42982 0 0 0 A0A8C0P1Q2 A0A8C0P1Q2_CANLF Death inducer-obliterator 1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351] metal ion binding [GO:0046872] EEWFHGDCVGISEARGRL;EGTPSWASD;GEDEDDTSDSDSD;KEDRRAEERTTAP;KRCHPPWWQKEPCWRFLEGEQL;LRGPLRILGVKRCHPPWWQKEPC;PHNNRFMICCDRCEEWFHGDCVGI;STSEGKGG;VLTTVTVSGRDP 9 9.5 0.99133 -0.54675 0 0 0 0 0 0 10.9058 0 0 0 0 0 0 0 8.68503 A0A8C0P1Q6 A0A8C0P1Q6_CANLF Cyclin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] FILKEYMNKQTD;LQEKNTTDEESLLNKP;PRSEEETLFKEPLSFQEKP;SLIKQPLAFL;SLMEKPTSVQEEAD;VYICTYMCVFLIHNS 6 6.9 1.0021 -0.9875 8.89491 8.1115 0 10.234 6.6744 0 0 0 0 0 0 0 0 0 0 A0A8C0P1Q7 A0A8C0P1Q7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] CTGSWAQSVLTQPASVSGS;DYVGWYQQLPGTRPRTLI;MIFTMAWSPLFLSL;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 38.3 0.98641 -0.42838 0 0 0 0 0 0 10.6171 0 0 0 0 0 0 0 0 A0A8C0P1T7 A0A8C0P1T7_CANLF Transmembrane protein 132B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CVAELELLPEWFSSG;EEDGKWENNI;ELLPEWFSSGL;MVVSVQGN;PNIDEHQGGTNDI;TRDSEDEEDEEKKG;TTVNFTHQ 7 6.4 0.9836 -0.25362 0 0 0 0 0 8.34367 0 0 0 0 0 0 0 0 0 A0A8C0P1V2 A0A8C0P1V2_CANLF H15 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527] LSLLNLLRPRRRAPRKLSLRRR 1 8.4 0.97359 0.046699 0 0 0 0 6.07423 0 0 0 0 0 0 0 0 0 0 A0A8C0P1W0 A0A8C0P1W0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] HLSRPTLTLPPAL;WKPGGRGESRFLSP 2 12.9 0.98982 -0.20123 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4814 A0A8C0P1W9 A0A8C0P1W9_CANLF Tubulin/FtsZ GTPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525] VGHSGGAL 1 4.1 0.98922 -0.26408 0 0 0 0 0 0 12.4137 0 0 0 0 0 0 0 0 A0A8C0P1Y5 A0A8C0P1Y5_CANLF F-box/SPRY domain-containing protein 1 (F-box only protein 45) Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; synapse assembly involved in innervation [GO:0060386] SCF ubiquitin ligase complex [GO:0019005]; synapse [GO:0045202] GAVGGAGAGAGGAAGAGGRLP 1 7.5 0.87285 0.14277 0 0 0 0 0 0 0 0 0 8.68937 0 0 0 0 0 A0A8C0P1Y7 A0A8C0P1Y7_CANLF CCDC144C-like coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KMEIEQKSQNEQDKVNKYMGK;NEQDKVNKYMGKHESLEERLSQPQ;VLSQQFSEAKSKFNTLEIEL 3 17.3 0.98744 -0.3546 10.3856 0 0 0 7.0568 0 0 0 0 0 0 0 12.3228 6.18535 0 A0A8C0P216 A0A8C0P216_CANLF Keratin 5 KRT1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; plasma membrane [GO:0005886] structural constituent of skin epidermis [GO:0030280] DEINKRTNAENEF;EAEALYQTKYEELQQTAGRH;GGFGLGGG;GGGGGGGA;NAENEFVTIK;QISETNVILSMDNNR;QNAIADAEQR 7 12.8 0.98498 -0.25935 0 0 0 8.07275 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P220 A0A8C0P220_CANLF Interleukin-1 receptor accessory protein-like 1 (X-linked interleukin-1 receptor accessory protein-like 1) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of exocytosis [GO:0045920]; signal transduction [GO:0007165] axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020] hydrolase activity [GO:0016787] ETQLGDSANLT;RDLIPTGTYIEDV;VGENDTGLCY 3 5.1 0.98751 -0.37835 0 0 0 0 9.7681 0 0 0 8.67105 9.44667 0 0 0 0 0 A0A8C0P230 A0A8C0P230_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] ligase activity [GO:0016874] GSLPMPHEGFLP 1 2 0.94491 0.05044 0 0 10.3108 0 0 0 0 0 0 0 0 10.2603 0 10.2099 10.5561 A0A8C0P240 A0A8C0P240_CANLF Transmembrane protein 109 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to gamma radiation [GO:0071480] membrane [GO:0016020] LAVKEEDHAGPQGPCLLR;LLLGLVLAVLGRILWGLKLVL;LSSPPLCS 3 13.4 1.002 -0.68188 0 0 0 0 0 0 0 0 0 9.98 0 0 5.21156 0 0 A0A8C0P248 A0A8C0P248_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PSLGFRGPGGPG;VPTTLALILLALLGLLMKR;VTELTKSDSGIYACG 3 7.9 0.94469 0.05044 0 0 0 0 0 5.78128 0 0 0 0 0 0 0 0 0 A0A8C0P251 A0A8C0P251_CANLF Arachidonate 15-lipoxygenase type B Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440] cytoplasm [GO:0005737] "iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" HPLLERALRDLPSARG;KTWVRNAE;LSLLVDHLPAPLSSWKTYSP;PRWGFRADVTWPPSPAALAPEYTFE;VGPLLLLRV 5 11.8 1.0019 -1.261 8.83001 0 5.3216 7.28031 0 0 9.72098 0 0 0 0 0 0 10.423 0 A0A8C0P265 A0A8C0P265_CANLF U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] small-subunit processome [GO:0032040] EALLPYTERHFQRLS;LSKGTAPDS;LVKLWTIK;PGGCDGAVRVW;TWNTNSRHCHEAQA 5 6.3 1.0016 -2.6282 0 0 0 0 0 7.35738 3.57942 0 0 10.7323 0 0 0 0 0 A0A8C0P272 A0A8C0P272_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] TEGRYSLIFQ 1 8.2 0.98845 -0.22689 0 0 11.3072 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P276 A0A8C0P276_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LGQVGQVGQAGQVGWSG;PLHPEASGAPGA;VFLRAPFSK;VGQAAQAGQ;VGQADQVGQAGQVGWLG;VGYIDSSINNVS 6 5.7 1.0018 -1.4151 0 8.28951 8.69404 0 0 0 10.8553 10.5974 8.2446 0 0 0 0 7.9982 0 A0A8C0P282 A0A8C0P282_CANLF Fork-head domain-containing protein FOXE3 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GPPPSPLAGAEPGPEPAG 1 5.8 0.98409 -0.23844 0 0 0 0 0 0 8.41819 0 0 0 0 0 0 10.6928 0 A0A8C0P294 A0A8C0P294_CANLF Src like adaptor SLA Canis lupus familiaris (Dog) (Canis familiaris) LAVLSDYPSPDIS;SLSNSLCRQRA 2 5.8 0.98564 -0.4433 0 0 0 9.98939 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P299 A0A8C0P299_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LPFVLSQREWSCK;WQPIFCVLR 2 3.9 1.0015 -0.69644 0 0 0 0 0 0 0 13.013 0 11.9791 0 0 0 0 0 A0A8C0P2D1 A0A8C0P2D1_CANLF "Tsukushi, small leucine rich proteoglycan" Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] NHDTPTMLWPLLLPP 1 4.1 0.95351 0.053888 0 0 0 0 0 8.62242 0 0 0 0 9.55614 0 9.72676 0 0 A0A8C0P2D3 A0A8C0P2D3_CANLF Aldehyde dehydrogenase Canis lupus familiaris (Dog) (Canis familiaris) cellular aldehyde metabolic process [GO:0006081] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" DLALKNLHNWMKDEP;LGRVRRLRGLL 2 6 0.93653 0.09715 0 0 0 0 0 0 0 0 0 0 0 0 7.18676 4.31266 0 A0A8C0P2D7 A0A8C0P2D7_CANLF Gap junction protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] SESTKKHK 1 3.1 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.75522 A0A8C0P2E1 A0A8C0P2E1_CANLF Sosondowah ankyrin repeat domain family member B Canis lupus familiaris (Dog) (Canis familiaris) GDLERAARSAG;GPGPRAAARGAAAETRG;GRVPGPARGRWGH;NAALLSHFRSFLRDPDAPPGQ;RRELFKGFVNAVAA 5 7.8 1.0025 -1.0111 10.1064 0 0 0 0 0 0 10.5706 0 11.8494 0 0 0 8.70463 0 A0A8C0P2F1 A0A8C0P2F1_CANLF RGS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] ACCFCWCC;ACCFCWCCCCSCS;ACCFCWCCCCSCSC;ACCFCWCCCCSCSCLTV;AGANACCFCWCCCCS;AGANACCFCWCCCCSC;AGANACCFCWCCCCSCSC;AGANACCFCWCCCCSCSCLTVRN;ANACCFCWCCCCS;ANACCFCWCCCCSC;ANACCFCWCCCCSCSC;ANACCFCWCCCCSCSCL;ANACCFCWCCCCSCSCLT;ANACCFCWCCCCSCSCLTV;CCCCSCSCLT;CCFCWCCCC;CCFCWCCCCSC;CCFCWCCCCSCSC;CCFCWCCCCSCSCL;CCFCWCCCCSCSCLTV;CFCWCCCCSCS;CFCWCCCCSCSCL;CFCWCCCCSCSCLTV;CWCCCCSCSC;CWCCCCSCSCLT;CWCCCCSCSCLTV;EQGSAGANACCFCWCCC;EQGSAGANACCFCWCCCC;EQGSAGANACCFCWCCCCSCSC;EQGSAGANACCFCWCCCCSCSCL;FCWCCCCSCSCL;GANACCFCWCCCC;GANACCFCWCCCCS;GANACCFCWCCCCSCSC;GANACCFCWCCCCSCSCL;GSAGANACCFCWCCCCSCSCLTV;NACCFCWCCCCS;NACCFCWCCCCSCSCL;NACCFCWCCCCSCSCLT;PEQGSAGANACCFCWCCCCSCSCL;QGSAGANACCFCWCCCCS 41 11.1 0.99879 -2.9782 9.7665 8.92831 9.15294 7.03342 6.82248 9.29637 7.26847 7.10381 8.29627 5.91569 7.52951 5.66397 5.88002 6.81429 8.57475 A0A8C0P2G3 A0A8C0P2G3_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] DAAGAPRKPRWA;FLRAWTVERKRLGRLLRI;LWNMYVEEEVFDCDNLYH;NVLLEDDGDFST;NWQFQEEKSKPGMNL;NWQFQEEKSKPGMNLKDLQNEEE;PISSWNQQF 7 6.9 0.94654 0.05044 0 0 0 0 0 0 0 0 0 7.2293 0 0 0 0 0 A0A8C0P2I1 A0A8C0P2I1_CANLF UDENN FNIP1/2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] DEAIVMPGTVITTTLE;ESSDSALGDSESED;GEPVWLTM;KKIAVGTE;LTMMSGTPEKNQLCHRFMKE;PGIVRKKKIAIGVIF;QTTSLENGVFP;TDIKEHCCMLEFSKGLC;VEKKPPDKLV;VLQGIGSDERLRQC 10 12.6 1.0037 -1.1044 11.5088 5.56502 14.2672 0 0 7.84562 0 5.7498 5.83777 0 0 0 10.707 5.37396 5.0419 A0A8C0P2J7 A0A8C0P2J7_CANLF Histone H2A Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] LTNEFMMPMARA 1 9.2 0.95045 0.05044 0 0 0 0 0 0 0 0 10.2046 0 0 0 0 0 0 A0A8C0P2K0 A0A8C0P2K0_CANLF Olfactory receptor OR51E1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RQRILRLF 1 2.5 1.0033 -1.1044 1.91804 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P2K5 A0A8C0P2K5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] HSAEKPYEC;IVINKRKRIKNKAIN;SKVTIIVINKRKRIK;VTIIVINKRKRIKNKAINN 4 5.3 1.0017 -0.64692 3.66209 0 0 0 3.7229 0 8.14873 0 0 5.06983 0 0 0 0 0 A0A8C0P2K8 A0A8C0P2K8_CANLF Leucine rich repeat containing 49 Canis lupus familiaris (Dog) (Canis familiaris) LNGLDSLTELNLR;NLNGLDSLTELNLRHNQ;TEEERRMASI;TLNYTTRD 4 5.6 1.0022 -1.4212 0 0 0 0 8.90965 0 0 10.5488 0 0 9.87181 0 6.65978 0 0 A0A8C0P2L0 A0A8C0P2L0_CANLF KIAA1549 like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATRLPPVP;IAEPLEYP;IDEVRQQMHMLL;KNDFKPDTMM;NCGCCQCD;NCGCCQCDISAGACSDAGSCE;QQKVTKEEARKRNVP;SLVLRTDNLQIT 8 6.2 1.0034 -1.3351 0 0 0 8.36089 0 0 0 0 5.80103 0 0 0 0 1.34551 0 A0A8C0P2L3 A0A8C0P2L3_CANLF Microtubule associated scaffold protein 1 MTUS1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] NLKNPQLMYLEQE;SNEKDLETQNHT 2 2.1 0.99544 -0.082683 0 7.46565 0 0 0 0 0 0 0 0 0 10.9594 0 0 0 A0A8C0P2L4 A0A8C0P2L4_CANLF Albumin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CQEENKTECFQMKLE;TCCQAESSEMCFREEV;VIRESHERVKNHC;VIRESHERVKNHCDLHEKLGDAYFH 4 10.1 0.94108 0.10311 0 5.45151 0 0 0 0 7.65707 0 0 0 0 0 0 0 0 A0A8C0P2L8 A0A8C0P2L8_CANLF Transmembrane protein 132C TMEM132C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGASEGLAERDAPGPA;GAAPGGGR;GVAGQRGG;HDCPGPRAGRQRRRQPAAAQRRRPA;QLSELRLDSNVV 5 4.8 1.0036 -1.6006 0 4.46205 0 0 10.56 0 0 0 9.1879 0 0 0 0 4.60905 0 A0A8C0P2N5 A0A8C0P2N5_CANLF DUF255 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] AAWASLPVRSVRALA;AFQISGDEFYSDVAKGI;PSGLRSHARPPGGARRPATRRR;RQVPPSAATMNSR;SVGYSTCHWCHMMEEE;VGGTYFPPE;VGYSTCHWCHMMEE 7 9.3 0.98902 -0.50808 0 10.679 6.66803 0 0 0 9.23692 0 11.6893 0 0 0 5.57987 0 8.52172 A0A8C0P2Q1 A0A8C0P2Q1_CANLF RanBP2-type domain-containing protein YAF2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] GGGGGGGG;MEGRDSEIHITWGDQ;VGSGGGGGGG 3 10 0.99587 -0.095783 0 0 0 0 0 0 0 9.30344 0 0 0 0 0 0 0 A0A8C0P2R6 A0A8C0P2R6_CANLF Homeodomain interacting protein kinase 3 HIPK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FSPLPLKVIRPI;LPSPTIHQTQY;YNISHPSG 3 2.7 1.0027 -1.3888 0 9.84147 0 0 0 0 0 0 0 0 0 0 0 3.78157 0 A0A8C0P2S4 A0A8C0P2S4_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] LSLMGWATVYMVH 1 4.6 0.93786 0.059735 0 0 0 0 0 0 0 0 0 9.05536 0 0 0 0 0 A0A8C0P2T0 A0A8C0P2T0_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] ASVSSYAGGVPPTLNEDLE;LDMYMENLE;PAPSEGATPASP 3 8.8 0.99536 -0.15795 0 0 0 10.0338 0 0 9.72054 0 0 0 8.64147 0 0 0 0 A0A8C0P2T1 A0A8C0P2T1_CANLF Nuclear pore complex protein Nup98-Nup96 NUP98 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] AVFVLLHIDNSSMRE;ELRLEDYQANRK;FSSQNNAFA;GVLQTSYAGQLE;HIASSLGI;LFGNSQTKPGG;LTWTLCEAL;NYEGRLEAVSRKQGAQFKEYRPETG;VGYYTIPSMDDLAKI 9 6.9 1.0023 -1.8786 0 7.82972 0 0 0 0 0 10.5692 0 0 0 0 7.08778 0 0 A0A8C0P2T7 A0A8C0P2T7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] IYGELYKNRVN;TEPEEEDDYRQEDERSTG 2 9.3 0.98472 -0.23907 0 0 11.41 0 0 0 0 0 8.47249 0 0 0 0 0 0 A0A8C0P2V2 A0A8C0P2V2_CANLF "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155)" MGAT5 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] extracellular region [GO:0005576]; Golgi membrane [GO:0000139] "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]" LEKRKRKKVLVHLG;LGFVVEQH;SLVALEKI;TLRELTSQHPYAEVF 4 6.5 1.0018 -1.2487 10.0859 0 6.31415 0 0 0 0 9.92776 8.42937 0 4.9834 0 0 0 0 A0A8C0P2X8 A0A8C0P2X8_CANLF Neutral ceramidase (EC 3.5.1.23) Canis lupus familiaris (Dog) (Canis familiaris) ceramide catabolic process [GO:0046514] ceramidase activity [GO:0102121]; N-acylsphingosine amidohydrolase activity [GO:0017040] ATSATWQIVHND;GKTFGDVLQ;IEMAHRNMKPG 3 5.1 0.99319 -0.55638 9.05183 0 0 0 0 0 0 0 0 0 0 0 9.61883 9.04767 0 A0A8C0P2Y7 A0A8C0P2Y7_CANLF Zinc finger and SCAN domain containing 12 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]" EILLKNQCELEAGVN;LLVLEQFLTILPEELQ;QEVSEEMEPCGNMFRF;SQHLLFIEHQ 4 9.5 0.98622 -0.41674 0 8.20945 0 0 0 0 12.0673 0 0 0 8.96503 0 0 0 0 A0A8C0P337 A0A8C0P337_CANLF Solute carrier family 35 member F5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DNA binding [GO:0003677] FICRKHRIQRVPEDSE;SSLSEPLYVP 2 5.5 0.99441 -0.56222 0 0 0 6.42774 0 0 0 9.22875 0 0 0 0 0 0 0 A0A8C0P348 A0A8C0P348_CANLF Transmembrane and coiled-coil domains 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CSCSDCQSP;ECSSEPYCSCSDCQ;EPYCSCSDCQ;KRECSSEPYCSCSDCQ;SEPYCSCSDCQS 5 9.8 1.002 -1.2552 0 8.08635 3.29916 3.43962 0 0 0 3.29668 0 4.30356 0 0 4.33099 0 0 A0A8C0P363 A0A8C0P363_CANLF Zinc finger matrin-type 3 ZMAT3 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] NSCPPPARMSNVVEPVAPP;SKQHKSKVSEQR 2 10.7 0.99188 -0.55016 0 0 0 0 5.72544 0 0 0 0 8.39343 0 0 0 0 0 A0A8C0P372 A0A8C0P372_CANLF S100/CaBP-9k-type calcium binding subdomain domain-containing protein S100A13 Canis lupus familiaris (Dog) (Canis familiaris) DVNQDSELKFHEYWRLIGELAKPC 1 26.1 0.97488 0.043694 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5999 A0A8C0P387 A0A8C0P387_CANLF 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of quinolinate biosynthetic process [GO:1904985] cytosol [GO:0005829]; membrane [GO:0016020] aminocarboxymuconate-semialdehyde decarboxylase activity [GO:0001760]; hydrolase activity [GO:0016787] FYAVAEKLNCSL;GVQIGSHINEWDLNARELFPFYAVA 2 11.5 0.99358 -0.28595 0 18.2913 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P396 A0A8C0P396_CANLF C2H2-type domain-containing protein PLAGL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AHCEKTFNRKDHLKNHL;DLPLQEPQ;KAHAEEKP 3 7.9 1.0031 -0.97593 0 0 0 0 0 0 0 0 0 0 7.07221 0 0 0 0 A0A8C0P399 A0A8C0P399_CANLF Kazal-like domain-containing protein SLCO6A1 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] KGNIPRWITFSSFLVGF;QDALAEVEPEVAPAQLAENAQ;QEFGTSLKDLFSTI;QRLNNIYCFMIFY;TLHIPVKNLKVKRKGK 5 12.2 0.99338 -0.061176 0 0 0 5.54646 6.56665 0 0 0 0 0 0 0 0 6.04941 0 A0A8C0P3A8 A0A8C0P3A8_CANLF ATP-grasp domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carnosine biosynthetic process [GO:0035499] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carnosine synthase activity [GO:0047730]; metal ion binding [GO:0046872] KLEFGAGAVGV;LLMEFVEGT;PGEYEEPYC;WARSAAAEEAAAAPLVE;YYYSLLQSCLQ 5 6.2 1.0018 -1.4184 0 13.1899 0 0 9.84721 0 0 0 0 0 0 6.0321 5.67779 9.43198 0 A0A8C0P3B0 A0A8C0P3B0_CANLF Large ribosomal subunit protein eL32 RPL32 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] GVPLKNQEVEDIVIYL;SEAKVLYMIQKEHEAQ;YHPHHWWPIGNTNYM 3 8.2 0.9944 -0.12698 0 0 0 0 0 10.852 11.3574 0 0 8.97951 0 0 0 13.7807 0 A0A8C0P3B2 A0A8C0P3B2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;VQPLWKTVWRLLKQLKI 5 4.7 0.97699 0.046227 0 0 0 0 0 0 0 0 0 0 0 4.57289 0 0 0 A0A8C0P3D6 A0A8C0P3D6_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] ALDIEIATYRT;DIEIATYRT;FLKALYDAELSQMQ;QVKTQEREQIKTL 4 6.4 0.94406 0.061141 0 8.48667 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P3D8 A0A8C0P3D8_CANLF Olfactory receptor OR52A17 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSLAMLGATHIALSTCVL 1 5.7 0.95012 0.049776 0 0 9.66473 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P3F1 A0A8C0P3F1_CANLF Solute carrier family 7 member 7 SLC7A7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] VFCLCTIFLVAVPLY;YSALFSYSGWDTL 2 5.5 0.95316 0.053903 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.0036 A0A8C0P3F3 A0A8C0P3F3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GSGGLLGTGLLKTGRVLVNGG;QSGKGPMNGQ;SEAGSSLAHNQFGYSIS 3 5.5 0.99517 -0.56382 0 4.72645 0 0 0 0 0 7.95146 0 0 0 9.28492 8.73302 0 0 A0A8C0P3F7 A0A8C0P3F7_CANLF Alpha-1D adrenergic receptor (Alpha-1D adrenoreceptor) ADRA1D Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] alpha1-adrenergic receptor activity [GO:0004937] AAGGGGGG;GGGAGGAA;LQTVTNYFIVNLAVADLLLSATVL;PGAPEAQGPVAGRRKPPCAFRE;VPGAAGGG 5 11.5 0.99331 -0.174 0 9.06018 0 0 0 0 0 6.52489 0 0 0 0 0 0 0 A0A8C0P3H0 A0A8C0P3H0_CANLF Methylosome protein WDR77 (Methylosome protein 50) (WD repeat-containing protein 77) Canis lupus familiaris (Dog) (Canis familiaris) oocyte axis specification [GO:0007309] methylosome [GO:0034709]; nucleus [GO:0005634] GAVELWELD;WHPQQSEVFVFGV 2 6.8 0.9449 0.05966 0 0 7.26529 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P3H2 A0A8C0P3H2_CANLF Piwi like RNA-mediated gene silencing 4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] RNA binding [GO:0003723] ETSKGETVKMTI;RPGPPATPPSH;RRAWGGRPGPPA;SPICIQVLNIIFKKIFKKLA;VAEDFLHCLRRAGSSMG;YYDSIKKY 6 7.6 1.0029 -1.5112 8.73363 0 0 7.37825 0 9.35134 0 5.57277 0 0 0 10.1821 0 8.2341 0 A0A8C0P3H4 A0A8C0P3H4_CANLF Microtubule-associated protein MAP4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] GLASRGNFKKEC;MKKKKKKPKQ;PEPNAVTKTAGPIASAQKP;PPAGKVQI;TQDKQVCRPS 5 2.5 1.0042 -1.0981 0 8.70753 0 0 0 0 0 10.4313 0 0 0 9.45716 0 8.53302 0 A0A8C0P3I1 A0A8C0P3I1_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PRDALGWAGP 1 3.5 0.99051 -0.2674 0 0 0 0 0 0 0 0 0 0 9.13945 0 0 0 0 A0A8C0P3K0 A0A8C0P3K0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESVLGWVFLVAILQ;EVQLLESG;EVQLLESGG;EVQLLESGGD;EVQLLESGGDRV;EVQLLESGGDRVKPG 6 23.4 0.98226 -0.24861 0 0 0 0 13.1695 0 0 0 0 0 0 0 0 0 0 A0A8C0P3K5 A0A8C0P3K5_CANLF MARVEL domain-containing protein MARVELD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HRAFLRGPLGVLRLLQLLAGAA 1 12.8 0.97371 0.046699 0 0 0 0 0 0 5.45124 0 0 0 0 0 0 0 0 A0A8C0P3K9 A0A8C0P3K9_CANLF PDZ domain-containing protein GRIP2 Canis lupus familiaris (Dog) (Canis familiaris) DESFPEEEEEEDWEPPT;HVKLPKRRGVEL;LFQVEYDV;PPGGAHEDIHK;QVEYDVAIPD;YTAQAAARGMTP 6 5.5 1.002 -0.90308 4.99241 8.57546 0 0 0 0 0 9.47602 0 10.946 0 0 0 11.4794 6.21331 A0A8C0P3L2 A0A8C0P3L2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGEDLVKPGG 3 20.1 0.99455 -0.1262 0 0 0 0 0 0 9.528 0 0 0 0 0 0 0 0 A0A8C0P3M6 A0A8C0P3M6_CANLF U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] small-subunit processome [GO:0032040] GSLSSLKHA;LSKGTAPDS;LVKLWTIK;PGGCDGAVRVW 4 3.5 1.0038 -0.80421 0 0 0 0 0 0 0 7.65542 0 0 0 0 0 0 0 A0A8C0P3M7 A0A8C0P3M7_CANLF Solute carrier family 23 member 2 SLC23A2 Canis lupus familiaris (Dog) (Canis familiaris) L-ascorbic acid metabolic process [GO:0019852] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] IVSCPSFLSP 1 3.3 0.99811 -0.61146 0 8.16596 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P3N3 A0A8C0P3N3_CANLF HUS1 checkpoint clamp component LOC119865601 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA integrity checkpoint signaling [GO:0044778]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; nucleotide-excision repair [GO:0006289]; telomere maintenance [GO:0000723] checkpoint clamp complex [GO:0030896]; site of double-strand break [GO:0035861] ERGQSATGVRWPWS;VEKMKNISNHLIME 2 6.9 0.94361 0.061061 0 8.10664 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P3N4 A0A8C0P3N4_CANLF Homeobox domain-containing protein NKX2-2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GKKRKRRVL;VLSVAIIIIII;VLSVAIIIIIIIII 3 8.4 0.98545 -0.24555 0 0 0 0 5.38488 0 0 0 0 0 0 0 0 6.43434 0 A0A8C0P3N6 A0A8C0P3N6_CANLF Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) NFKB1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AALLMDHPNGE;FSDSFGGG;LFCFVLMHSSR;RHANALFDYAVT;SGGGGGGA;TAGPKDMVVGTFPRL;TALHLAVEHD;VCEGPSHGGLPGA 8 8.7 1.0031 -2.3454 8.46883 10.0139 9.76406 0 0 0 0 0 0 0 7.97871 8.91037 9.87836 9.70901 0 A0A8C0P3P4 A0A8C0P3P4_CANLF E1A binding protein p400 EP400 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] AKRQEWTEPNSFNVCIAPYKQFFRG;EEEEEEEEEEEEEK;EHVLKCRLSSRQ;HKVVIRLHRVTQPFILRRT;KASTSLTDDEVEDEEETIE;LLQAVKQLLELPLNLTIVSP;LPESSYTAGP;LTAVREWEA;NDLDLEEEEEEEEEEEEEE;PNSFNVCIAPYKQFFRGYASFMR;PPIKPLLG;QFQGNKFT;QHLQGNMMDFLAFKKKHYAPLQAY;QVELEEKRKKALTLQK;REERGRKE;YQVQQLMNRSPVTGQNVNIALQ 16 8.2 0.99713 -3.6305 0 0 6.34243 7.23055 11.193 0 7.08693 9.81532 6.9905 7.89051 8.58763 0 0 12.44 0 A0A8C0P3Q9 A0A8C0P3Q9_CANLF Ubiquitin associated and SH3 domain containing A UBASH3A Canis lupus familiaris (Dog) (Canis familiaris) ALRCVQTAKHILEELKLEKKIKIRV;MCFCEENK;PQEYALFLCPTGPLLEKLEEF;TVAAATGGLSPCERSPR 4 9.7 1.0018 -1.3116 0 8.76431 6.97223 0 6.7271 0 0 0 0 0 0 0 0 0 0 A0A8C0P3R1 A0A8C0P3R1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) protein localization to microtubule [GO:0035372] microtubule [GO:0005874] microtubule binding [GO:0008017] ESSLKKSHT;RDPSQTLEMNLTNLV 2 4.7 0.95021 0.053891 0 0 0 0 0 0 0 0 0 6.33162 0 0 0 0 0 A0A8C0P3R9 A0A8C0P3R9_CANLF Calponin-homology (CH) domain-containing protein FLNB Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] intracellular non-membrane-bounded organelle [GO:0043232] actin filament binding [GO:0051015] AGQHISKS;ASKCLATGPGIASTVKTGEEV;ATFTIVTEDA;DGVYAFEYYPSTPGKYS;EAGLLSVDCSEAGPGALGLE;GFLDGVYAFEYYPS;GVRIRETADF;LAEDAPWKKIQ;PVPGSPYTVEASLP;RDAGYGGISLAVEGPS;VGSLGFAI;VKYNDKHIPGSP;VSYLPTKPG 13 6.2 1.0015 -2.6516 0 0 10.6387 6.31386 0 6.1456 10.4058 0 10.2389 12.6738 9.08114 0 11.2649 0 7.89712 A0A8C0P3T1 A0A8C0P3T1_CANLF Arf-GAP domain-containing protein GIT2 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; regulation of ARF protein signal transduction [GO:0032012] nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] LILKTISNQHSI;NIYQVQTGSEYTDTSN;SIWEHSLLDPA;VNPEYSSTRNQ 4 6.6 0.86527 0.13516 0 0 0 0 8.22415 0 8.64821 0 0 0 15.5219 0 0 0 0 A0A8C0P3T5 A0A8C0P3T5_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] AAEDIQVN;FVVCLVVLLRIIILLIIIP;LLRIIILLIIIPPE;LVVLLRIIILLII;LVVLLRIIILLIII;LVVLLRIIILLIIIP;LVVLLRIIILLIIIPP;LVVLLRIIILLIIIPPECSL;SVAFEACLAQLFF;VAIFWFGCC;VCLVVLLRIIILLIII;VLIKRLHIF;VLLRIIILLII;VLLRIIILLIII;VVCLVVLLRIIILLIIIP;VVCLVVLLRIIILLIIIPP;VVLLRIII;VVLLRIIILLII 18 20.9 1.0008 -2.7553 5.57101 9.03364 0 4.49927 4.7845 5.04155 6.82362 7.50359 0 6.31513 9.89486 0 0 0 5.67404 A0A8C0P3V2 A0A8C0P3V2_CANLF P-type Cu(+) transporter (EC 7.2.2.8) ATP7B Canis lupus familiaris (Dog) (Canis familiaris) copper ion export [GO:0060003]; copper ion import [GO:0015677]; intracellular copper ion homeostasis [GO:0006878] plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; P-type divalent copper transporter activity [GO:0043682] GVPEETDETPQ;ISSLKGIVSIKISLEQ;KYCKEELGTETLGYCTD;LSSLQLKCYKKPDLERYEAQA;LSTQEAVITYQ;PPGTVGGVPEETDET;PSAHHLDHKVE;VGIPIAAGV 8 7.6 1.0019 -1.4196 8.72363 12.2527 0 3.15023 0 6.94673 7.76613 0 8.54473 8.63826 7.35773 7.62373 0 14.6735 5.63709 A0A8C0P3X7 A0A8C0P3X7_CANLF Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] IPVPSPDFPPPPPESSLVFP;KDDGKKSW;LDWSLVETI;PPPESSLVFPP;QKKSQYIK;QMERIFEDHENLVENLLNWT;THQGQPITEHAISL 7 6.4 1.0025 -1.7871 0 0 13.2723 9.591 0 0 0 8.90713 0 0 0 0 0 0 0 A0A8C0P410 A0A8C0P410_CANLF Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) PGR Canis lupus familiaris (Dog) (Canis familiaris) nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518] cytoplasm [GO:0005737]; nucleus [GO:0005634] estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270] AETYDAGA;APAAAAAAGCSA;CLICGDEASGCHYGV;LVKQLHLYCLNTFIQSRAL 4 6 1.0019 -1.2482 0 0 0 0 0 0.309875 0 7.48671 10.1946 0 0 0 0 7.06512 0 A0A8C0P414 A0A8C0P414_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AENAIQQMGG;AGLKIILVSGKKIKV;PNQPAGYRVAGLKIILVSGKKIKVL 3 8.5 0.99403 -0.17239 0 0 0 3.61624 0 0 5.60395 0 0 0 0 0 0 0 0 A0A8C0P460 A0A8C0P460_CANLF Sin3A associated protein 25 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] ALPCPPDAAC;PSFWPLYEAASGRDLSPLA 2 6.9 0.99411 -0.56172 0 0 0 0 0 8.99664 0 0 10.0315 0 0 0 0 0 0 A0A8C0P461 A0A8C0P461_CANLF Exportin-1 C-terminal domain-containing protein XPO1 Canis lupus familiaris (Dog) (Canis familiaris) protein export from nucleus [GO:0006611]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] AYMFNLVEEGKI;CNEFSQIFQLCQFVM;IIASNIMYIVGQY;KEHLRDFLVQI;QEEAAAQSFYQ;QILKQEWPKH;SLFLCTFLKEHGQLIEKRLNLRE;VGEVMPFI;YMLLVSEVEE 9 11.2 0.99774 -3.3548 0 9.31825 0 0 9.34058 0 9.66775 0 10.5388 0 0 0 8.71836 0 8.10507 A0A8C0P483 A0A8C0P483_CANLF BolA family member 3 Canis lupus familiaris (Dog) (Canis familiaris) protein maturation by [4Fe-4S] cluster transfer [GO:0106035] mitochondrial matrix [GO:0005759] KEEIKGMHGLRIF 1 12.6 0.99016 -0.26643 0 0 10.1716 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P4A0 A0A8C0P4A0_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723] AKTYAAEYTLQ;PALANQNPTIHPFTP;PFTPPKLSA;RALVQRTGYSLVQENGQRKY 4 9.5 0.99607 -0.10109 9.40378 0 0 9.04171 0 0 0 0 11.273 0 0 0 0 0 7.25001 A0A8C0P4A3 A0A8C0P4A3_CANLF POU domain protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGGGGGDW;GGGGGGGD;GGGGGGGG;HGKAGGGG;LPAGGGGGG;PGGGEPAP;PGGGGGGL;RRRRRRRPAARAGIQSAR 8 8 1.0009 -2.7547 4.64881 10.4013 12.1514 0 0 0 0 8.201 0 0 0 10.8716 0 0 0 A0A8C0P4A7 A0A8C0P4A7_CANLF Secreted frizzled related protein 5 SFRP5 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] AQKKKKLLKPGPLKRKDTKRLVL;KKKKLLKPG;LETPRAMRGPAGGAR;QKKKKLLKPGPLKRKDTKRL 4 9 1.0016 -0.91862 5.08593 0 0 0 8.9691 0 0 0 0 0 2.5214 2.40926 0 0 0 A0A8C0P4A8 A0A8C0P4A8_CANLF Nucleoside diphosphate kinase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ILMQRQIILSEE;VLNEEEAEKI 2 4 0.99088 -0.26903 0 0 0 0 5.53608 0 0 0 0 0 0 0 0 0 0 A0A8C0P4B0 A0A8C0P4B0_CANLF Adipocyte plasma membrane-associated protein APMAP Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] membrane [GO:0016020] strictosidine synthase activity [GO:0016844] FSMLDFLS;WQRRDYLLLVMEG 2 5.1 0.98889 -0.52279 9.52421 0 0 0 0 0 0 0 0 0 0 0 0 11.21 0 A0A8C0P4B2 A0A8C0P4B2_CANLF Transmembrane channel-like protein TMC7 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] AIATLKFII;AIATLKFIII;FFSCPESLSL;LLTKYNITNST;LVIFLIIFMLVLLPVLLTKYNI 5 6.9 0.9995 -0.61146 0 0 0 0 0 0 0 0 8.6522 0 0 0 0 0 0 A0A8C0P4B4 A0A8C0P4B4_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] GLSHHYVP;LSHHYVPCSLRT;PAGTPAVDTS;VGKSVTEDLV 4 5.2 1.0038 -1.6834 0 9.28695 0 0 0 8.7086 0 0 0 0 0 0 0 0 0 A0A8C0P4B6 A0A8C0P4B6_CANLF Erythrocyte membrane protein band 4.1 like 5 EPB41L5 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] ASDCCQCG;RYSGKTEYQTTKT;VKARDGND;VPIQTEEMELAIFEKWKEYR 4 10.1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 3.8748 0 0 0 0 0 A0A8C0P4C2 A0A8C0P4C2_CANLF SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (HepA-related protein) (Sucrose nonfermenting protein 2-like 1) SMARCAL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] EDGSDLELLEAAE;TNSSQSRQGLPPNL 2 3.1 0.98958 -0.20225 0 0 9.30353 0 0 0 0 0 0 0 0 7.48776 0 0 0 A0A8C0P4C5 A0A8C0P4C5_CANLF Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 PCMTD1 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737]; membrane [GO:0016020] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] KRKRKRVKQ;PPKRKRKRVKQRI 2 3.7 1.0014 -0.74465 0 4.15478 0 0 0 0 0 0 0 0 0 0 0 0 3.52067 A0A8C0P4C7 A0A8C0P4C7_CANLF Cytoskeleton-associated protein 2 C-terminal domain-containing protein CKAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GVNLESGKPET;QEKTSKLPDMLKDHYP 2 4.2 0.99006 -0.20027 0 0 9.71994 0 0 0 0 9.82354 0 0 0 0 0 0 0 A0A8C0P4E4 A0A8C0P4E4_CANLF GRB2 related adaptor protein 2 GRAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] QHRYLQHPHFHQE;SQYAPAPPTQQHRYL 2 7.3 0.86855 0.13416 0 0 0 0 0 0 9.1719 0 0 0 0 0 0 0 9.4153 A0A8C0P4E6 A0A8C0P4E6_CANLF Transmembrane protein 196 TMEM196 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] EHKPQLGD;SEREHSLHHS 2 10.5 0.9963 -0.57342 0 0 0 0 0 0 0 0 0 10.939 0 0 0 0 0 A0A8C0P4G0 A0A8C0P4G0_CANLF Neuronal cell adhesion molecule NRCAM Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] DPEIQPMKED;PDRVFNTPEG;PIYDVPNPPFDLELTDQ;SNVLPEDTRE;VLSLECIAEGLPTPI 5 5.5 1.0019 -1.4731 0 9.89149 0 9.6637 0 0 12.9594 0 0 0 0 0 9.47354 0 0 A0A8C0P4I7 A0A8C0P4I7_CANLF FAT atypical cadherin 1 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AILPLEIFIT;CNCSQDYRGRHCEDAAP;CSDVSACCEVESEVMMSDYESG;DIQIVSLQPSE;EAGNELDLFSLNPNSGVLSLK;ESGDDGHFE;FDVVVEVTQEQKP;FIEIYIEVE;GLGEGIGILV;GLITTTSRKLDREQQDEHILE;IIVEDINDNP;IVSGNDDGAFEVN;LFAEYAANV;LKIEARDQAREE;LSTSETLD;NGGTCFDSLDGAVCQCDSG;QFRATKYEVDIGSNAPKGTSV;QVRATDSDSEPNRGISYHM;SACCEVESEVMMSDYESGDDG;SFQSESCDDNESLAAPDL;TATEDCSSSPCQNGG;TYSIISGNEHGKF;VPVGSSVM;VSACCEVESEVMMSDYE;YLLHVKVADNGKPQLSS 25 7.1 0.99737 -3.8242 8.66203 10.775 12.3374 10.7049 0 10.6863 0 8.28623 11.3436 8.52497 10.2471 9.62253 10.7699 7.62549 10.3738 A0A8C0P4J3 A0A8C0P4J3_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] APEVLEEQIRTD;GQGWRRTLSSPLEVTNTASSP;QPWPGPRQCV 3 6.7 0.98939 -0.51997 0 0 0 8.97739 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P4K1 A0A8C0P4K1_CANLF Ephrin-B1 EFNB1 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013] plasma membrane [GO:0005886] ephrin receptor binding [GO:0046875] CVIFLLIIIFLTVLLLKLR;EAGRPYEYYK;IFLLIIIFLTVLLLKL;IFLLIIIFLTVLLLKLRKRH;IIFLTVLLLKLRK;LLIIIFLTVLLLKLRKR;LTVLLLKLRKR;LTVLLLKLRKRHRKH;TVLLLKLRKRHRKHT;VGAGCVIFLLIIIFLTVLLLKLR;VGAGCVIFLLIIIFLTVLLLKLRK;VIFLLIIIFLTVLLLK;VIFLLIIIFLTVLLLKLR;VIFLLIIIFLTVLLLKLRKRHRK 14 11.6 0.66142 0.31453 10.7886 10.6816 9.27661 0 0 5.50507 10.0741 9.51519 5.94195 4.79769 4.21901 0 0 6.94181 9.64274 A0A8C0P4K6 A0A8C0P4K6_CANLF Carbonic anhydrase (EC 4.2.1.1) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] SIWLFRKKSSK;WSYFGPNGEKSWSEKYPSCGGVLQS 2 10.5 0.93857 0.071029 0 0 0 0 0 0 0 0 0 0 0 8.64256 0 0 0 A0A8C0P4L0 A0A8C0P4L0_CANLF DZF domain-containing protein ILF2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] catalytic step 2 spliceosome [GO:0071013] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725] MLTNETGFEI;TVKVLIRLLKDLRIR;VKVLIRLLK;VKVLIRLLKDLRIRFPG 4 7.8 1.003 -0.8822 8.23726 0 0 0 3.58063 0 0 0 0 0 4.58262 0 0 0 0 A0A8C0P4L1 A0A8C0P4L1_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) TRIP12 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] nuclear speck [GO:0016607] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EDDEDSDD;EPIGRVEP;HVFFSSPLPGEEPI;IDESLAAQFLNSGNV;NIAETLHFLLCGASNG;PESESTSDNCPE;TAKANRQLQ;TCLCFARLVDNFQHEENLLQQ;TIHNLEEYLRL;TIHNLEEYLRLV;WYYLYDNAMCKEI 11 6.3 1.0034 -2.0551 0 0 5.4364 10.6693 0 0 0 11.4368 10.5231 0 0 7.50367 9.95559 9.80218 5.00167 A0A8C0P4M0 A0A8C0P4M0_CANLF Protein Flattop (Cilia- and flagella-associated protein 126) CFAP126 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] VAGAASLTKWIQKNP 1 8.5 0.87792 0.1402 0 0 0 0 0 9.62575 0 0 0 0 0 0 0 0 0 A0A8C0P4M4 A0A8C0P4M4_CANLF Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EDDDDKGDSF;EEEDEDEDDDD;EEEEEEEEEEEEEEEEEDGSS;EEEEEEEEEEEEEEEEEEED;GEEEEEEEEEEEEEEEEEEE;LDCQGEEEEEEEEEEEEEEE;PSESEEEEEEEEDEDEEEDEDEDD;SEEEEEEEEDEDEEEDED;TSVPSQGG;TVESEEASTLT 10 12.9 0.88475 0.12511 0 0 0 0 6.82094 0 0 0 0 0 0 3.45088 0 5.20398 0 A0A8C0P4N0 A0A8C0P4N0_CANLF Metal transporter Canis lupus familiaris (Dog) (Canis familiaris) intracellular manganese ion homeostasis [GO:0030026]; magnesium ion homeostasis [GO:0010960] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] ADGARLSAYCPDYTVRAFSDLQLI 1 6.7 0.97467 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.638 A0A8C0P4P6 A0A8C0P4P6_CANLF Endothelin-2 (Preproendothelin-2) Canis lupus familiaris (Dog) (Canis familiaris) regulation of vasoconstriction [GO:0019229]; vasoconstriction [GO:0042310] extracellular region [GO:0005576] FAHGSPLP 1 2.4 1.0042 -1.1044 9.18125 0 0 0 0 0 0 0 0 0 0 9.37132 0 0 0 A0A8C0P4Q6 A0A8C0P4Q6_CANLF Primary cilia formation Canis lupus familiaris (Dog) (Canis familiaris) VGYHETCGNENRH;VIEESLVNYPFGTSQPRK 2 12.5 0.92737 0.10793 11.5961 0 0 0 8.48152 0 0 0 0 0 0 0 0 0 0 A0A8C0P4W5 A0A8C0P4W5_CANLF Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) maturation of SSU-rRNA [GO:0030490] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] AIPVMLHGREL;IPVMLHGREL;QDEEKKEESLTERKRE;SIGAGFNP;VIHADRTQQQR;VIQQAGCPVPEYIKGFQK 6 11.3 0.98487 -0.25935 0 0 0 0 0 0 8.82817 0 0 0 0 0 0 0 0 A0A8C0P4Y2 A0A8C0P4Y2_CANLF Proteasome subunit alpha type PSMA7 Canis lupus familiaris (Dog) (Canis familiaris) proteasomal protein catabolic process [GO:0010498]; ubiquitin-dependent protein catabolic process [GO:0006511] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" KKGSTAVG;YLWLWSIPGGGGAG 2 7.7 0.99661 -0.57953 0 10.0172 0 0 0 0 10.4026 10.115 0 0 0 0 0 0 0 A0A8C0P4Z4 A0A8C0P4Z4_CANLF USP domain-containing protein USPL1 Canis lupus familiaris (Dog) (Canis familiaris) Cajal body organization [GO:0030576] SUMO binding [GO:0032183] FQESIFLCEDLQ;GQIHKLRLKLLKKLK;GQIHKLRLKLLKKLKA;GQIHKLRLKLLKKLKAKKKKL;GQIHKLRLKLLKKLKAKKKKLAA;HCGSRNNCESIEDLLKE;HKLRLKLLKKLKAKKKKLA;HLPDLPQTGP;IHKLRLKLLKKLKAK;IHKLRLKLLKKLKAKK;KLLKKLKAKKKK;KLLKKLKAKKKKLAA;KLRLKLLKKLKAKKKKLAA;LESKCTSL;LKKLKAKKKKLAAL;LKLLKKLKAKKKKL;LKLLKKLKAKKKKLAAL;LLKKLKAK;LLKKLKAKKK;LLKKLKAKKKKL;LLKKLKAKKKKLAAL;LRLKLLKKLKAKKKK;LRLKLLKKLKAKKKKL;LRLKLLKKLKAKKKKLAAL;RLKLLKKLKAK;RLKLLKKLKAKKKK;RLKLLKKLKAKKKKLA;RLKLLKKLKAKKKKLAAL;SLNNLISP;SVEGQIHKLRLKLLKKLKAKKK;VEGQIHKLRLKLLKKLKAKKKK;VTVGEQVLNSK 32 8.8 1.0028 -1.1977 5.65163 8.60977 7.59731 4.96014 4.74578 10.8788 6.30828 11.0613 8.43609 12.4489 6.93758 5.5359 7.80019 8.94207 9.45687 A0A8C0P501 A0A8C0P501_CANLF Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (Skeletal muscle enolase) ENO3 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] DLGGQRGGS;FFLLLILLLLLLLQLPFL;FYRNGKYDLDFK;KIFLLLFLLLLLLLLFL;LFFLKIFLLLFLLLLLLL;LFLLLLLLLLFL;LKIFLLLFLLLL;LKIFLLLFLLLLLLL;LKIFLLLFLLLLLLLL;LKIFLLLFLLLLLLLLFLL;LKLLLKLL;LLFLLLLLLLLLITA;LLKLLFFLLFLLKILFLLLFFL;LLLLLFLLLLLLLL;LLLLLFLLLLLLLLL;LLLLLFLLLLLLLLLIT;LLLLLFLLLLLLLLLITAVDV;LLLLLLFLLLLLLLLLITA;LLLLLLLL;LLLLLLLLL;LLLLLQLPFLFLKLLLKLLFF;LLLLQLPFLFLKLLLKL;LLLQLPFLFLKLLLKLL;LPFLFLKLLLKLLFFLL;QLIQLFFLLLILLLLLLLQLPFLFL;RDGDKSRYLGKG;TNVGDEGGFAPNILENNEALELL 27 19 1.0021 -0.71243 7.24355 7.88228 4.62281 5.85382 4.81563 7.3474 11.1505 7.19446 10.2718 6.07611 5.44679 5.62205 9.33595 5.30279 0 A0A8C0P509 A0A8C0P509_CANLF General transcription factor IIIC subunit 4 GTF3C4 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] transcription factor TFIIIC complex [GO:0000127] histone acetyltransferase activity [GO:0004402] EGGGEAGGK;FWRFKLFLLRIL;VHSIKCVPLYHPYQKCSCSL 3 5.2 0.83624 0.1969 0 0 0 0 0 12.1684 0 0 8.75151 0 0 0 0 0 0 A0A8C0P510 A0A8C0P510_CANLF Myosin VC ARPP19 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AILHLGNV;EQTESMKGKLE;FSISRSHFLNDYCS;IIVPGMLEYESLQ;IVVMENNIQ;KNLQNSLAK;LEDQNKENHGLV;VAIRIYHRFIVVME;VQVTAVGNERSSVSEDDRHLEVFCE 9 5.6 1.003 -0.78754 0 0 0 0 0 0 11.2592 0 0 8.01419 0 0 0 0 0 A0A8C0P511 A0A8C0P511_CANLF Hexosyltransferase Canis lupus familiaris (Dog) (Canis familiaris) PCPRASSLPWMPSLPPA;TPLRGAAHGRLGAHPRQQ 2 6.6 0.92746 0.096041 0 8.66984 0 0 0 0 0 10.0887 0 0 0 0 0 0 0 A0A8C0P532 A0A8C0P532_CANLF Cilia- and flagella-associated protein 418 CFAP418 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917] ACDFRVVSYDDYMWDHSC;GVGGGVTS 2 9.4 0.9897 -0.26592 0 0 0 9.19518 9.65109 9.62419 0 0 0 0 8.28021 8.26533 0 8.5014 0 A0A8C0P547 A0A8C0P547_CANLF Integrator complex subunit 10 INTS10 Canis lupus familiaris (Dog) (Canis familiaris) snRNA processing [GO:0016180] integrator complex [GO:0032039] RVQCEMLLKVTEQCF;SSPPMGLLQ;VLDLMCYMVLPIQD 3 5.7 0.99113 -0.14633 0 0 0 0 0 0 7.79299 0 9.47644 0 0 0 0 0 12.2902 A0A8C0P566 A0A8C0P566_CANLF 2'-5' oligoadenylate synthase (EC 2.7.7.84) LOC477518 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087] cytoplasm [GO:0005737] nucleotidyltransferase activity [GO:0016779] AHRRSIISFIKKRL;DNFNLDEGFRAVMELL;GPDQEVRVLKVVKV;VLKVVKVGSF 4 5.4 1.0037 -0.82322 0 0 0 0 0 0 0 0 10.4954 0 0 0 0 0 5.15725 A0A8C0P587 A0A8C0P587_CANLF Zinc finger C2HC-type containing 1B ZC2HC1B LTV1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] IPIVKKAPQSKPQSM;TAANRHIN 2 10.6 1.0043 -1.1044 0 0 0 0 0 0 0 9.53953 0 0 0 0 0 0 0 A0A8C0P589 A0A8C0P589_CANLF NSF attachment protein beta NAPB Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] EEACEMYT;HYEQSADYYKGEESNSSAN 2 9.6 1.0031 -1.3361 0 0 0 0 0 4.53288 0 0 0 0 4.46904 0 0 10.3677 0 A0A8C0P591 A0A8C0P591_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP34 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DPVFAEYIKCILMDERTFLNNNIV;IDSTWQDETNQVEE;IVYTFMTHFLLKVQ;KCPNQIVRQMFQ;LCSLVCWFTDRQ;LDLAFKYFMSP;LNEISDIEGGDGLQ;SDTEESMQGSSDETANSGEDGSSGP;TLLIPETAVRHES;TVRCQVADMKNIYESL;TYTMDKQPLNT 11 4.7 0.9867 -0.38427 11.5362 0 10.9789 0 10.3412 8.93168 10.5123 0 5.24367 8.35971 7.87848 7.80568 10.3106 0 0 A0A8C0P598 A0A8C0P598_CANLF Aminoglycoside phosphotransferase domain-containing protein ACAD10 Canis lupus familiaris (Dog) (Canis familiaris) LAVLHWEFSTV;LHWEFSTVGDPLVDV;LTEQASSAATKQNEKLIEYMSNL;RQQKMTVVHGDFRLDNLVF;SAAGIGMVIPLSF 5 11.6 0.99347 -0.044905 11.7436 9.25958 0 8.9578 0 0 0 0 0 0 0 12.1644 0 12.7922 8.64569 A0A8C0P5C5 A0A8C0P5C5_CANLF RAS like family 10 member B RASL10B Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] FSWEVLFWSQ;PAPVQLVSWQQ 2 7.9 0.99682 -0.57597 0 7.20016 0 0 0 0 0 0 0 0 6.84649 0 0 0 0 A0A8C0P5C7 A0A8C0P5C7_CANLF E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] HLFCGTCIIAYWRYGSWLGAISCPI 1 4.2 0.97948 0.035538 0 0 6.86864 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P5D0 A0A8C0P5D0_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1" SMARCC1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; SWI/SNF complex [GO:0016514] histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492] HGQNPQQAHQHSGGP;LGKHYKKAKCFM;NETDEGDKAQDGEN;QVLVHWGF;TVAANIHPPGSGPAAPG 5 6.2 1.0024 -0.66576 0 0 0 0 0 0 8.77679 10.6791 0 7.35244 9.65939 9.90213 0 0 0 A0A8C0P5D6 A0A8C0P5D6_CANLF FCS-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] ATKKKKKQFGKKRKRIPPTKTRP;CSRSYSSN;EDGDSDDDFWCHMWSP;ELTGYQLQ;FDGWDSEYDQWVDCESPD;GVPSTARSLCPLGMVESMK;KAKEATKKKK;KKKKKQFGKKRK;KKKQFGKKRKRIPPTKTRPL;PTKKAKVLH;SDDDFWCHMWSPL 11 16.8 0.94872 0.049568 0 0 0 0 0 0 0 6.58996 0 0 0 0 0 0 0 A0A8C0P5E2 A0A8C0P5E2_CANLF Solute carrier family 39 member 8 SLC39A8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion transmembrane transporter activity [GO:0046873] GVGGAAAGPALAFSEDVLSVFGAN;ILTFFVGLAIGTLFS;LVGNNFAPN 3 10.4 1.0029 -1.122 0 0 0 0 9.98996 0 10.1882 0 0 0 0 0 0 0 10.0947 A0A8C0P5H1 A0A8C0P5H1_CANLF Transglutaminase-like domain-containing protein EPB42 Canis lupus familiaris (Dog) (Canis familiaris) protein-glutamine gamma-glutamyltransferase activity [GO:0003810] FLEAPSSLYLGG;GWQILYPRVSSGGGV;LLLQVMGKKPLLLGQ 3 6.1 0.99021 -0.2048 0 0 0 0 0 0 7.1632 0 0 0 0 0 8.5043 0 0 A0A8C0P5J3 A0A8C0P5J3_CANLF Dpy-19 like 4 DPY19L4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DKLTYSKYGRFCHET;FLEVKFGLNMTKNFTMNWLLCQ;KWLRLRTVHPVLLALILSMAVP 3 7 0.99442 -0.15668 0 0 0 0 0 0 11.2038 0 7.33727 0 0 0 9.52264 0 0 A0A8C0P5J6 A0A8C0P5J6_CANLF Glycerophosphocholine phosphodiesterase 1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] phosphoric diester hydrolase activity [GO:0008081]; starch binding [GO:2001070] EGLEEDDDDRVS;NRKKLKELGVNGLIYD;PPVSITKKKLKKSRFRVKL;SVQYRYFKGCFLEPKTIGGP;TKKKLKKSRFRVKLTLEGLE 5 10.9 0.98741 -0.34909 12.1914 0 0 0 5.72765 0 8.9646 0 5.52209 0 0 0 0 4.82089 0 A0A8C0P5J8 A0A8C0P5J8_CANLF Ig-like domain-containing protein IGLL5 Canis lupus familiaris (Dog) (Canis familiaris) AVFGGGTHL;GGTHLTVLG;GGTHLTVLGQ;GGTHLTVLGQPKA;GSPVTQGVETTK;GSPVTQGVETTKPSK;GSPVTQGVETTKPSKQ;GTHLTVLG;GTHLTVLGQ;GTHLTVLGQPKA;GVTVAWKADGSPVT;KADGSPVTQGVE;KADGSPVTQGVET;KADGSPVTQGVETTK;KADGSPVTQGVETTKPS;KADGSPVTQGVETTKPSKQ;KADGSPVTQGVETTKPSKQS;LTVLGQPKA;SPVTQGVETTK;SPVTQGVETTKPS;SPVTQGVETTKPSK;SPVTQGVETTKPSKQ;SPVTQGVETTKPSKQS;SPVTQGVETTKPSKQSN;THLTVLGQPKA;TVLGQPKA;TVLGQPKAS;TVLGQPKASP;TVLGQPKASPS;TVLGQPKASPSVTL;TVLGQPKASPSVTLF;TVLGQPKASPSVTLFPPSSEELG;VFGGGTHL 33 64.8 0.021505 1.1492 11.0614 9.89539 9.73742 8.34283 8.52191 9.42715 7.44294 7.29581 0 0 7.76049 9.22337 0 7.83876 7.95018 A0A8C0P5K6 A0A8C0P5K6_CANLF Ankyrin repeat domain 13A ANKRD13A Canis lupus familiaris (Dog) (Canis familiaris) late endosome [GO:0005770]; plasma membrane [GO:0005886] LLESSRSQE;LSARELEERE;SSGHFPLHLLVWNNDYRQLE;TVLHEAVSTGDPEM;YEIMQFAIQQ;YTVLQHRDYHN 6 12.5 1.0034 -2.224 0 10.1961 8.65746 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P5K7 A0A8C0P5K7_CANLF Interleukin-4 receptor subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) production of molecular mediator involved in inflammatory response [GO:0002532] membrane [GO:0016020] cytokine receptor activity [GO:0004896] DAGGPGFG;GCSECSCVSPGSVKVLHEPSCF;LSEAPVDNEEE;PSPCCGCCCG;PVDNEEEEEVEEDKRS;SGCSECSC;VPSPCCGCCCGDRS 7 7.8 0.99898 -2.9297 6.5171 9.35837 0 10.9009 0 4.66551 4.08899 2.53849 0 0 0 0 0 0 7.47208 A0A8C0P5L1 A0A8C0P5L1_CANLF MARVEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; synaptic vesicle [GO:0008021] EAGGPRARGGAYCAAA;YVLIGDYSSSAQFYVTFAVFVFLY 2 11.4 0.99203 -0.20678 0 0 0 0 0 0 0 0 9.67605 0 0 0 0 0 0 A0A8C0P5L2 A0A8C0P5L2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLSKLFRTLMDVPTVG;EEHLVAKG;ENKPYNNK;IDDIEDEH;IRLQNFNERQQIKA;IVQDILGNEHEHLY;KEAYEREKKV;LNEEWHSDNSD;NAQKGILFQEDQIL;QMQQQRVE;SECEYDSV;TSECEYDS;VLYEMCTLKHA 13 10.2 0.99742 -3.7684 0 0 0 6.11015 8.78198 4.97131 11.3429 10.5214 0 5.22632 0 0 0 0 0 A0A8C0P5N1 A0A8C0P5N1_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 20 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] CQFPNGQMSQEQNC;GVCGGDNS;GVCGGDNSS;GVCGGDNSSCRTMTGV;GVGRVAEEMCAQS;HQYHVMAPTLNYHTS;IKIYCAGMHSENPKEYI;NYHQPINENYCDPA;VGNLYNPDV;WSPCSASCGHG;YGSWGECTQTCGGG 11 6.4 1.0021 -1.1347 9.73478 0 9.52953 0 0 8.72028 0 11.8637 0 0 8.07746 0 13.2663 0 0 A0A8C0P5N2 A0A8C0P5N2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] PPLFFSFAGF;PSMSVTLRQT;SIGSKRVYWYQQKLGQV;YVLTQLPSM 4 14.3 0.98523 -0.25858 0 0 0 0 0 0 0 0 0 0 0 0 0 9.31485 0 A0A8C0P5P0 A0A8C0P5P0_CANLF RanBD1 domain-containing protein RANBP3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] DTCEEENCE;ESSDTCEEENCE;FRLKPPTLIHGQA;MPAPEPGAAPSNEDDSDED;PAIAPPVFV 5 7.6 1.0019 -1.2315 0 0 0 0 0 0 0 10.2515 0 0 0 4.94739 10.4713 12.2401 7.26585 A0A8C0P5P3 A0A8C0P5P3_CANLF Homeodomain-only protein (Odd homeobox protein 1) HOPX Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] DNA binding [GO:0003677] GAAPSPGG;TRTREVGSQPRDPS 2 10.9 1.003 -0.97807 0 7.92884 0 0 0 0 0 0 10.7551 0 0 0 0 0 0 A0A8C0P5Q3 A0A8C0P5Q3_CANLF Mitochondrial 2-oxoglutarate/malate carrier protein (Solute carrier family 25 member 11) SLC25A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] TSPKSVKF 1 3 0.99009 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1022 A0A8C0P5Q7 A0A8C0P5Q7_CANLF Small nuclear ribonucleoprotein G (snRNP-G) SNRPG Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal snRNP assembly [GO:0000387] catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; P granule [GO:0043186]; precatalytic spliceosome [GO:0071011]; SMN-Sm protein complex [GO:0034719]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] IFLNQSCNLYPFCFFRFM 1 12.5 0.97936 0.048313 0 0 0 0 0 0 0 0 0 0 0 6.79883 0 0 0 A0A8C0P5R4 A0A8C0P5R4_CANLF Elongation factor 1-gamma Canis lupus familiaris (Dog) (Canis familiaris) translational elongation [GO:0006414] cytoplasm [GO:0005737]; nucleus [GO:0005634] AFEGDDGFCVFESNAIAYYV;DGNLGQRKTLVGIWNQFWS;VLLEPSFCQAFPNTNRWFLTCI 3 17.4 0.93275 0.096755 0 0 0 0 0 0 0 0 7.08119 0 0 0 7.06544 0 0 A0A8C0P5R5 A0A8C0P5R5_CANLF Arf-GAP domain-containing protein SMAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096] EDNKFCADCQSKGP;GVQPAQQLQWNLTQVSY;SIANSKTSNTLEKDLDLLA;VEDLPNVKLSEE 4 13.3 0.98708 -0.36476 0 10.4521 8.16672 0 0 0 0 0 0 8.82585 0 0 0 0 0 A0A8C0P5S3 A0A8C0P5S3_CANLF Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] FKKKKKELGLVILQPRGP;GAGGRAGA;PVATLHPGRATAPPGAPGGPPCLQP 3 13.7 0.94284 0.083851 0 0 0 0 0 0 7.45294 0 7.87983 5.05489 0 0 0 0 0 A0A8C0P5S6 A0A8C0P5S6_CANLF Zinc finger and BTB domain containing 25 ZBTB25 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] ALAQRFQPYCDSWSD;DPESVISQSHPSPSSEV;GDVYFKAHRAVLAAFSNY;LGEVHPLNENNEAL;NQVFSPETVQSSNLYG;SEVTGPTFTESS;SHSLVLLQ 7 22.3 1.0028 -1.3411 0 5.44877 7.60058 0 9.69625 0 0 11.1558 7.51381 0 0 0 4.79551 0 0 A0A8C0P5S8 A0A8C0P5S8_CANLF Rho GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StAR-related lipid transfer protein 12) DLC1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] focal adhesion [GO:0005925]; membrane raft [GO:0045121] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] CVNYEGQSAYDVADMLKQYFRD;DILYHVKGMQRIVNQWSEKFSDEG;DLLDSKVIEILDSQT;EDEDQFLSLEASTET;EQHLWDVDLL;PGHISLRRENSSDSP;RRKLDFPKDEHERNTCSVVQDEFLA;VLLIMKLDQ 8 8.9 1.003 -1.5182 0 0 6.98687 9.73088 10.751 8.98379 0 0 12.1542 0 0 0 12.6677 0 7.39592 A0A8C0P5T2 A0A8C0P5T2_CANLF "Mucin 20, cell surface associated" Canis lupus familiaris (Dog) (Canis familiaris) hepatocyte growth factor receptor signaling pathway [GO:0048012] ETQTLSPQ;LVSVSVNPLE;VGTGMTTVET;VLSPPVVSALFNSTEAESH 4 8.9 0.99107 -0.18598 0 0 0 0 8.2457 0 0 0 0 0 0 0 0 0 0 A0A8C0P5V1 A0A8C0P5V1_CANLF Mitogen-activated protein kinase 6 (EC 2.7.11.24) LOC119881521 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EVRKDEQIEKENT;PVEDGKLGERGN 2 3.8 0.91471 0.11009 0 0 0 0 0 0 8.6923 0 0 0 0 8.58695 10.0906 0 0 A0A8C0P5W3 A0A8C0P5W3_CANLF Arsenite-resistance protein 2 SRRT Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; primary miRNA processing [GO:0031053] nuclear body [GO:0016604] nucleic acid binding [GO:0003676] QEEEEEQAGKPGE;RFFRRGWVTFDRSVNIKEICW;SSDPYHSGYEMPYAGGGGGPTYGPP 3 7 0.9851 -0.23675 0 0 0 0 0 0 0 5.26093 0 0 8.1152 0 0 0 0 A0A8C0P5X2 A0A8C0P5X2_CANLF Zonadhesin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDEDKECPKNTTNPSSCNSGF;ELMMPDEELAQ;IIPTEKTSVPTERP;LAHCGCTNNGV;LCEPLSCRAGEICTLG;LHMDSNTFHRGGV;NLTRGCFRESPCL;PHLGSVCVSLQASCL;TKKKHPSLLWK;VGPTVLSS;VLTERSTVTTERP 11 4.7 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.74352 0 0 0 A0A8C0P5Y6 A0A8C0P5Y6_CANLF Dedicator of cytokinesis 5 DOCK5 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DQEKIELLKRLIAL;EFNFSGNGN;EVKQISTEEISPL;GVAVMDITDII;ILLEKLLLEHCR;IMMEMSDNET;KILLEKLLLEHCRKHKYL;KLTEQLKPLHDRL;SVYDEEGKLLEKA;YLSLFHRSSLRITIY;YYVYTQQELKEK 11 6.8 0.9842 -0.24739 0 0 0 0 0 0 10.9508 0 0 0 0 0 0 0 0 A0A8C0P626 A0A8C0P626_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ERQTQRLI 1 3.1 1.0039 -1.1044 0 0 0 6.42801 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P631 A0A8C0P631_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087] nucleotidyltransferase activity [GO:0016779] LLPTFQCHEITQ 1 2.4 0.94453 0.05044 0 0 7.99305 0 0 0 0 0 0 0 0 0 0 0 8.1468 A0A8C0P639 A0A8C0P639_CANLF Epithelial stromal interaction 1 Canis lupus familiaris (Dog) (Canis familiaris) AFPDSQSSTWKL;WNMNSGNSWVSFFFSLKK 2 8.1 0.93467 0.098753 0 0 0 0 0 0 7.94539 0 0 0 0 0 0 8.53516 0 A0A8C0P645 A0A8C0P645_CANLF Histone H2A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleosome [GO:0000786] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] PSVPSRAAAGPQP 1 4.1 0.98287 -0.25189 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.1707 A0A8C0P652 A0A8C0P652_CANLF Protein phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] ADSTSFDVQLGDII 1 4.6 0.93733 0.066327 0 9.38422 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P654 A0A8C0P654_CANLF PHD-type domain-containing protein RSF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] RSF complex [GO:0031213] histone binding [GO:0042393]; metal ion binding [GO:0046872] DPPSNDDSDTD;EEEDFENVGKVGSPLDYSL;ESEESYMSK;ITNMKIGDLEKEV;LNDLDSDSNLDEEESEDEF;PEEEEDELLRVT;SAASEEEEEKESEEAILADD;VGRTLRRSPRISRPTAKV;YSLVDLPSTNGQS 9 9.1 1.0025 -0.72421 7.48132 0 10.836 0 5.32236 3.76564 5.74967 10.5781 5.28792 0 7.6686 9.59236 0 0 10.6167 A0A8C0P655 A0A8C0P655_CANLF Rhodanese domain-containing protein CEP41 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; protein transport [GO:0015031] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737] CPFLLLDVRDRDSYQ;GLITGSLPASCQQALPP;LSGGLKVLAQKF;SKAPGTRSGQTLPA;TPEDLKKIEYYLEED;TSRFHFSSLVSTFPEY 6 23.5 0.98201 -0.24965 0 0 0 13.2726 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P6A4 A0A8C0P6A4_CANLF RCSD domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) AANSADPT;EAGPPPAA;PKTEDPCPG;SAEAKEERAGNEEDEP;TEEKAPGEKTEE 5 10.8 1.0008 -2.7395 10.9763 0 8.3969 0 0 0 0 0 0 0 0 7.40523 8.66622 0 8.73254 A0A8C0P6B3 A0A8C0P6B3_CANLF UDP-glucuronic acid decarboxylase 1 UXS1 Canis lupus familiaris (Dog) (Canis familiaris) D-xylose metabolic process [GO:0042732]; UDP-D-xylose biosynthetic process [GO:0033320] cytoplasm [GO:0005737] NAD+ binding [GO:0070403]; UDP-glucuronate decarboxylase activity [GO:0048040] GNFVNMRSIQENGELKIE;RKAKMMLAWEPV 2 7.8 0.93395 0.098753 0 0 0 6.7362 7.81967 6.44369 0 0 0 0 0 0 0 0 0 A0A8C0P6B7 A0A8C0P6B7_CANLF Nuclear receptor subfamily 1 group I member 3 (Constitutive androstane receptor) Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] GHSSDWPTSPDIL;VTRREEIDHLQEV 2 6 0.9929 -0.17617 0 0 0 0 0 0 0 0 0 0 0 0 6.80413 0 0 A0A8C0P6C2 A0A8C0P6C2_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] AEGAEDCGPERRA;ALAHPISL;PSHAAAFGAPPAG 3 6.9 1.0024 -0.71611 0 0 10.5808 0 8.62571 0 0 0 0 0 0 0 0 0 0 A0A8C0P6C4 A0A8C0P6C4_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GVTLLYYGRYKASCI;VLAVNSQALAFQYVFAILNS 2 3.8 0.9908 -0.1457 0 0 0 0 0 0 0 0 11.4079 0 4.17975 0 0 0 3.3886 A0A8C0P6D3 A0A8C0P6D3_CANLF Apoptosis and caspase activation inhibitor Canis lupus familiaris (Dog) (Canis familiaris) ALPLELPQM 1 4.2 0.99032 -0.26765 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1886 0 A0A8C0P6D9 A0A8C0P6D9_CANLF Arylsulfatase (EC 3.1.6.1) (EC 3.1.6.14) (N-acetylglucosamine-6-sulfatase) Canis lupus familiaris (Dog) (Canis familiaris) cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; Golgi stack [GO:0005795] calcium ion binding [GO:0005509]; sulfuric ester hydrolase activity [GO:0008484] AGREEKRKKKLRKLLKRL;EKRKKKLRKLLKRL;EKRKKKLRKLLKRLQNN;KKKLRKLLKRL;KRKKKLRKLLKRLQ;MLVETGELDNTYIVYTAD;NIILVLTDDQDVELGSMQVMN;QPAGREEKRKKKLRKLLKR;RKKKLRKLLKRL;RKKKLRKLLKRLQ;RKKKLRKLLKRLQN 11 7.4 0.81903 0.20472 0 0 0 0 0 0 0 3.58664 0 4.44255 0 4.56517 6.69377 0 5.90456 A0A8C0P6F7 A0A8C0P6F7_CANLF C4a anaphylatoxin LOC481722 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]" axon [GO:0030424]; dendrite [GO:0030425]; extracellular space [GO:0005615]; synapse [GO:0045202] endopeptidase inhibitor activity [GO:0004866] AIHTEEIVYELNPLDH;ATSDLKGDPQYLLD;DDPDASSQTVTPLEL;DDPDASSQTVTPLELFERRRN;FSLGSKINV;GSKGVLSPGGL;GSKGVLSPGGLASL;IVYELNPLDHRA;KPRLLLFS;KPRLLLFSPSVVHL;KPRLLLFSPSVVHLG;KPRLLLFSPSVVHLGVPLSVG;LSIERPDPRPPRVEDTLNL;LVSAGSPHPAVARL;NLRAVGVSGD;NVNFQKAIHEKLGQYA;PDASSQTVTPLEL;PDASSQTVTPLELFE;PDASSQTVTPLELFERRRN;PHVLLYFDSVPTSRECVGF;PNIIPDGDF;PNIIPDGDFSSL;PRPPRVEDTLNL;PRPPRVEDTLNLNL;QDEAGYRMRFA;SHELQLNNHQVQGLEEELQF;SKGVLSPGGLASL;SLGSKINV;SSDPNIIPDGDFSSL;SSLVRVTASHPLDT;STLPPETKDHAVDL;SVVPTAATAVSL;TLEIPGSSD;TLEIPGSSDPNIIPD;TLEIPGSSDPNIIPDG;TLEIPGSSDPNIIPDGD;TLEIPGSSDPNIIPDGDF;TLEIPGSSDPNIIPDGDFSSL;TREANEDYEDYV;TVRAPPSGSSRF;TVRAPPSGSSRFLSIERPD;VALGAMDMAL;VQLLVSAGSPHPAVARL;VRVTASHPLDT;YHPGETVKLHLQTDSP 45 18.2 0 88.241 14.8349 14.6502 14.6038 11.99 12.1815 12.4028 15.5478 15.7604 15.9449 14.7626 15.1654 14.7509 14.954 14.8286 14.9634 A0A8C0P6F9 A0A8C0P6F9_CANLF Potassium channel tetramerization domain containing 9 KCTD9 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein homooligomerization [GO:0051260] DDVLFVCEGEPFI;DIALIRDDDVL;NVGGRYFTTT;PDSMLAHMF;VLEEARFFGIDSLIEHL 5 15.9 1.002 -1.408 9.61681 0 0 10.3471 0 0 0 0 0 0 9.823 0 0 0 7.56932 A0A8C0P6G3 A0A8C0P6G3_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF126 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; transferase activity [GO:0016740] GVSFSSSS;LVCGVGGG;SSSSPSNENPAGN 3 4.6 1.0031 -2.149 0 0 0 0 7.399 0 2.81652 0 0 0 0 0 0 9.83845 0 A0A8C0P6G7 A0A8C0P6G7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ACDSGGDCECFC;CGSPCADTCSNPEHSQLCEDHC;CVGDACACDSGGDCEC;DACACDSGGDCECF;DIQLVPIMQVFVRL;DSGGDCECFCT;DTCSNPEHSQLCEDHCM;EACVGDACACDSGGDCEC;GDACACDSGGDCECF;GDACACDSGGDCECFC;HTCPFTCPADKVYQ;ISVPKTTKTT;LDELGQDVICDKS;NCMFDTCN;NCMFDTCNCEKSEDCL;PEYITQLECRAE;PTVGLVCYNRNQ;TDHDDCCSMPAG;TEQCQDPVPVPMMDCSPGSSICE;VGDACACDSGGDC;VGDACACDSGGDCEC;VGDACACDSGGDCECFCTA;VGDACACDSGGDCECFCTAV;VTDHDDCCS;VTENVPCGTTGVTCSKAIK;YSNCMFDTCNCEKSEDCLC;YYNPEGQC 27 5.4 0.99731 -3.5196 10.6994 9.54353 6.6532 9.67539 7.00101 8.45578 0 10.3077 8.94152 0 0 11.1027 10.3424 7.93534 8.01447 A0A8C0P6N7 A0A8C0P6N7_CANLF Epidermal growth factor receptor pathway substrate 15 like 1 EPS15L1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; endosomal transport [GO:0016197] clathrin coat of coated pit [GO:0030132] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EAHWAVRVEEKA;GAVPVLPA;KEEAIRQKSNE;LDEMDQQKAKLRDM;SGLSDIILGKG;TSDPFTKNPSL 6 7.4 0.99602 -0.091318 9.02178 9.19658 0 0 0 0 0 0 0 0 7.28707 12.7559 0 9.5072 0 A0A8C0P6P8 A0A8C0P6P8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] LSPLLLNIVLEVLASAIRQ;MNEKGEITTNT;PSICCLQETHFRQ;SPLLLNIVLEV;YFYFMIVTERERERERQRHRQREKQ 5 6.1 0.97837 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 6.61786 0 0 A0A8C0P6Q2 A0A8C0P6Q2_CANLF "Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1)" NDUFAF1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] GACLWPRARSWRPGI;LVSFDKAIKDEI 2 8.8 0.94322 0.05044 0 0 0 0 0 0 0 0 0 0 6.02139 0 0 0 0 A0A8C0P6Q8 A0A8C0P6Q8_CANLF "Solute carrier family 2, facilitated glucose transporter member 3 (GLUT-3) (Glucose transporter type 3)" SLC2A3 Canis lupus familiaris (Dog) (Canis familiaris) dehydroascorbic acid transport [GO:0070837]; glucose import [GO:0046323] cell projection [GO:0042995]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] D-glucose binding [GO:0005536]; glucose transmembrane transporter activity [GO:0005355] ILQRLWGTQDVSQDIQEMKDES;MIGLGGMAVCSIL 2 8.5 0.99248 -0.032231 0 19.4261 0 0 0 0 7.67278 0 0 20.1219 0 0 20.2588 0 0 A0A8C0P6S7 A0A8C0P6S7_CANLF Sphingomyelin synthase 1 SGMS1 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; sphingomyelin biosynthetic process [GO:0006686] membrane [GO:0016020] ceramide phosphoethanolamine synthase activity [GO:0002950]; sphingomyelin synthase activity [GO:0033188] QYPMEWGKTCLAFLY;VLTTVMISVV;WGKTCLAFLYALSCFV;WYRPFQYFEKNVQGIVPR;YHWICWLL 5 13.6 1.0022 -1.2283 0 0 0 0 9.91106 0 0 7.6703 0 0 0 0 6.11026 8.85234 10.8552 A0A8C0P6T5 A0A8C0P6T5_CANLF Small ribosomal subunit protein uS14 (40S ribosomal protein S29) LOC100855430 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; rough endoplasmic reticulum [GO:0005791] structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270] NMCRQCFRQYAKY 1 23.2 0.99079 -0.26952 0 0 0 0 0 0 0 0 0 0 0 0 0 9.99365 0 A0A8C0P6T6 A0A8C0P6T6_CANLF Exonuclease 1 (EC 3.1.-.-) EXO1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] 5'-3' DNA exonuclease activity [GO:0035312]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] KFTRTISPPTLGTLRNCFSW;NIQLTPEAEEDIFNKPE;SEDDLLSQYSLS 3 6.2 0.99427 -0.13116 0 0 0 0 0 0 0 10.5338 0 11.2661 5.09896 0 0 0 0 A0A8C0P6T7 A0A8C0P6T7_CANLF Pleckstrin homology and FYVE domain containing 2 PLEKHF2 Canis lupus familiaris (Dog) (Canis familiaris) endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333] early endosome [GO:0005769] metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091] AAHAPGGG;AAPVHAQGRGRR;AKGGGRGAG;GVCGVCGM;LSVRRGARARV;NDVSDDDDDDDSSD;SDDDDDDD 7 7.9 1.0018 -2.6414 0 0 9.62225 0 0 0 0 0 12.8283 0 10.1625 7.98908 7.92125 0 0 A0A8C0P6V6 A0A8C0P6V6_CANLF Protein Wnt WNT8A Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] EAELIFLEES;ECLQDSHNTSRWE;FLPSAEAELIFLEE;GNSAEGHWAPTEAF;NCSMGDFENCGCDE;PESALQLSTHNRLRSATRETSF 6 23.8 1.0011 -0.62293 0 10.0564 0 0 0 0 14.8447 0 7.37955 0 0 0 7.09476 0 0 A0A8C0P6V7 A0A8C0P6V7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] non-membrane spanning protein tyrosine phosphatase activity [GO:0004726] LQGSGPSPLCVHCVLCTV;LYHTVAQMFSALQNTN 2 10.1 0.94209 0.10048 0 0 0 0 8.95823 8.89591 0 0 0 0 0 0 0 0 0 A0A8C0P6W6 A0A8C0P6W6_CANLF "Discoidin, CUB and LCCL domain containing 2" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSPREVTTMLQTDSAEYAQPL;PLSLLLLLILVLL;SFESHHEGMLN;VEQDKIFQGNKDYHQ 4 7.1 0.99398 -0.071793 0 0 0 0 8.1501 0 0 3.72825 9.45187 0 9.27968 0 0 0 0 A0A8C0P6X8 A0A8C0P6X8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] "aminoacylase activity [GO:0004046]; hydrolase activity, acting on ester bonds [GO:0016788]; metal ion binding [GO:0046872]" ITEAVHKVS;MHLCHYLLVALAWGSEPSSL 2 13.1 1.0026 -0.75465 9.03864 0 0 0 0 0 0 0 0 0 0 0 0 6.85062 0 A0A8C0P6X9 A0A8C0P6X9_CANLF RLF zinc finger RLF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DKKPIGSSERYQRWLQYK;GAGDGPET;HLMEQHNIEGEIHSD;HWPFDPEFWDW;IHSDYEIHCD;IICNLESEG;LELLLRLKHLSLKN;LETELREQE;QHFRDASYTCNFVGCKKFYYSKIEY;RLVLSCFELLLSVSESELPC 10 7.1 0.99985 -2.844 0 0 0 0 0 0 0 10.1253 9.47903 13.1683 8.10171 9.62461 0 0 9.4802 A0A8C0P6Z4 A0A8C0P6Z4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DTTISPDSTT;EVTTSTASPDVTT;ISTATPDTTTSIASPDI;MTTSTAWPD;SPDITTSTVF;SSVASTLTVSSD;TTAAVSPDGTTSA;TTTSIASPDISTSTT;TVSPDMSTSTMSPDMST 9 4.8 0.99563 -0.085625 0 0 0 12.6484 0 9.40926 9.0814 0 10.6255 0 0 0 0 0 0 A0A8C0P702 A0A8C0P702_CANLF Early growth response 4 EGR4 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] APATAGYPGAGDFLSW;LTPPGGEGGSRGD;NFSRSDHLTTHVRTHTGEKPFACDV;RPPAPISRR 4 10.7 1.0023 -1.3705 0 0 0 0 7.05246 0 0 0 0 0 0 0 0 0 10.4926 A0A8C0P704 A0A8C0P704_CANLF Latent transforming growth factor beta binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CCKNGEVIGAK;CEDHDECQDMACE;CEDVDECEDL;CEDVDECEDLQ;CIDIDECANDTMCGSHGFCD;ECCCQDGEA;EDHDECQDMACENGEC;FCSPPLTLDL;GGRCTNTEGSYHCQC;GLNLTEKIKKIKIVFTP;HDECQDMACENGECVNT;HYNAVHRKCEDHDE;IDIDECANDTMCGSHGF;IDIDECANDTMCGSHGFCDNT;LGHTCEDVDECEDLQS;PTGDCIDIDECANDTMCGSHGFC;QAECCCTQGASWGDTCDPCPAED;SYHCQCDQ;TTQAECCC;TYTECCCQDGE;TYTECCCQDGEAWSQQCAL 21 9.2 0.99708 -3.5843 12.1141 12.937 13.1913 12.0017 3.55471 6.62994 13.6129 13.0206 11.8738 12.8502 12.631 0 12.5893 5.46803 7.16541 A0A8C0P713 A0A8C0P713_CANLF ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) ABCC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ATVNEDSEEDDDCG;PILFSGSL;QDILVLEEVKKKKK;SSLMMVIY;TVNEDSEEDDDC;TVNEDSEEDDDCG;VHGHITIKGT;YSCLFFIGYALQ 8 4.4 1.0038 -1.1037 5.49956 0 0 0 0 0 0 11.5847 0 4.98605 4.55759 0 11.6946 0 11.5198 A0A8C0P714 A0A8C0P714_CANLF GTP-binding protein GEM Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] IVDGESATIILLDMWE 1 5.5 0.96028 0.049233 0 0 0 0 0 0 0 9.6818 0 0 0 0 0 0 0 A0A8C0P718 A0A8C0P718_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EVYRKPVDLD;GVSCLTTCASGGECLG;IPMKILPG;ITGSFQVLSSLIET;PKEVRLSPK;PLESPTLGDP;PPQTAGLIVL;SANKNLKF 8 5.2 1.0029 -1.7241 13.0521 8.58485 0 0 0 12.3393 7.09919 11.4489 10.0723 8.03331 0 0 0 0 0 A0A8C0P721 A0A8C0P721_CANLF Protein chibby homolog 2 (Spermatid-associated protein) CBY2 Canis lupus familiaris (Dog) (Canis familiaris) LHRTYTWH;SGSSGDEEMK 2 4 1.0019 -1.4274 0 0 0 0 0 0 10.0823 10.3949 0 0 0 0 0 0 0 A0A8C0P723 A0A8C0P723_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CFRCHHRVFPPG 1 3.9 0.99197 -0.18103 0 0 0 0 0 8.05148 0 0 0 0 0 0 0 0 0 A0A8C0P724 A0A8C0P724_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] LSQADDVKLQ;LSSTENLKFRRHLL;SPAVFGNTVQLISPVPRGKVPIL;VISTEPSPGERQP 4 7 0.99093 -0.26788 0 11.4594 0 0 0 8.73545 0 0 0 7.9157 0 0 0 0 0 A0A8C0P735 A0A8C0P735_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cellular response to vascular endothelial growth factor stimulus [GO:0035924]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; response to cytokine [GO:0034097]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019] CGYPPFYS;DMWSLGVIMYILL;LLLKRRKKARAL 3 8.1 0.94181 0.05044 0 0 0 0 4.74465 0 0 0 0 0 0 0 0 0 0 A0A8C0P765 A0A8C0P765_CANLF Pepsin A (EC 3.4.23.1) PGA Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] HNRFNPQESSTY;IVKIPLVRKKSL;KIPLVRKKSLRQKLIEHGLL;VKIPLVRKKSLRQKLIEH 4 8.8 0.99372 -0.16212 0 0 0 0 0 0 6.38855 0 0 0 5.84589 0 7.802 0 0 A0A8C0P769 A0A8C0P769_CANLF Leptin receptor overlapping transcript-like 1 LEPROTL1 Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; negative regulation of growth hormone receptor signaling pathway [GO:0060400] endosome [GO:0005768]; membrane [GO:0016020] IARRLVDD;LSGRRRRRRRRRASPV;LSGRRRRRRRRRASPVSRLPAA;PLFVLFFY 4 14.3 1.0012 -0.92577 0 0 0 5.66823 0 0 0 0 0 0 0 9.01137 0 0 0 A0A8C0P771 A0A8C0P771_CANLF Protein phosphatase 1 regulatory subunit PPP1R12A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] A band [GO:0031672]; stress fiber [GO:0001725]; Z disc [GO:0030018] enzyme inhibitor activity [GO:0004857]; phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] DIEEKENRDSSS;EAETDKTKPMASVT;EEEGKKDESSCSSEEDEEDD;GVSFWTQDSDENE;ISEMEEELKMLPDLKADNQ;MEELLQNEVNRQGV;SPKEEERKDESPASWRLGLR;TAGVMRSASSPRLSSSLD;TNTNTSST 9 15.5 0.99669 -0.58628 0 0 9.67082 0 10.6118 3.40667 0 0 0 0 8.38909 0 0 0 0 A0A8C0P780 A0A8C0P780_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALDGGDPP;DRGFFEIDPVNGE;IVQENNTPGAYLLSVSARDPDLG;KVEIKDLNDNAP;LDPRQASAFRVV;NPSSGLLVTKQ 6 9.1 0.98757 -0.39952 8.42257 0 0 10.156 0 9.28792 11.5154 10.3138 5.58907 0 0 0 10.7211 0 0 A0A8C0P789 A0A8C0P789_CANLF Olfactory receptor LOC119867629 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFRRLILRIFLIKK;VISYGGCVAQL 2 8 0.93979 0.060769 0 0 0 0 0 0 4.11403 0 0 0 0 0 0 0 0 A0A8C0P799 A0A8C0P799_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092]; protein tyrosine phosphatase activity [GO:0004725] AEHTHDQVVL;TSLCSTLL;YLSDYSFIPNQPQDFEKEIAKL 3 4.2 0.99638 -0.57656 0 0 0 0 0 0 0 9.64353 10.7879 0 0 0 0 0 0 A0A8C0P7A3 A0A8C0P7A3_CANLF Disks large homolog 1 DLG1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; receptor clustering [GO:0043113] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; endoplasmic reticulum membrane [GO:0005789]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] kinase binding [GO:0019900] EFYEVTLLDNP;GGAAAQDGRLRVNDCI;IDIQEFYEVTLLDNPKC;SEIENVHGFVSH 4 4.8 1.0027 -0.77176 0 0 12.0402 0 0 0 0 0 0 0 9.70974 0 0 0 0 A0A8C0P7A6 A0A8C0P7A6_CANLF Autophagy-related protein 16 domain-containing protein ATG16L1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045] CQELRSKLQDLERANQTLKDEYD;ERKSDQEKYNRGK;FPVPQDNVDTHP;VIVDETSDHAEETSP 4 9 0.99399 -0.11941 0 0 0 0 0 0 0 7.8254 0 0 0 0 0 7.24422 8.82136 A0A8C0P7A9 A0A8C0P7A9_CANLF Small VCP interacting protein SVIP Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly [GO:1904240]; positive regulation of autophagy [GO:0010508]" endoplasmic reticulum membrane [GO:0005789] VGSGRARG 1 4.2 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 11.8535 0 A0A8C0P7B7 A0A8C0P7B7_CANLF Oncostatin M Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; oncostatin-M-mediated signaling pathway [GO:0038165] extracellular region [GO:0005576] cytokine activity [GO:0005125]; oncostatin-M receptor binding [GO:0005147] FMRSVGQVFRE 1 4.6 0.98439 -0.25512 0 0 0 0 0 0 0 0 0 0 0 0 12.359 0 0 A0A8C0P7C7 A0A8C0P7C7_CANLF Nuclear Testis protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDEGEDEGEDAGEDE;EGEDEGEDEGEDAGEDEGLSGF;ETLQPACPGN 3 6.5 0.94354 0.10057 6.65292 0 6.70238 2.80447 0 0 0 0 5.07348 0 1.39402 0 0 0 0 A0A8C0P7C8 A0A8C0P7C8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HQGFLQDKELPGPS;PSEKLRLRVY 2 7.4 1.0027 -0.77135 0 0 0 0 0 0 0 3.88421 8.64879 0 0 0 0 0 0 A0A8C0P7D0 A0A8C0P7D0_CANLF ADAM metallopeptidase domain 33 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AGDAHGNC;ECDCGSQPGRECQDACCLAHNC;EEGEECDCGS;EQCQQLWGPGS;GACPTLEEQCQQLWGPGS;GVCNSNKNCHCAPGWA;GVPCRRAVGDCDLP;IVNSAGDA;IVNSAGDAHGNCGQD;PDIYLLDGSPCASGRG 10 13.3 0.99349 -0.2792 0 0 0 0 0 0 0 0 0 9.95556 0 0 0 0 0 A0A8C0P7F3 A0A8C0P7F3_CANLF Complement C3 LOC484960 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]" extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] FQGNREATMSIIEVSLLTGFYP;IIDVTAEMLPSFR;IKASGSGR;IVSGYTQMLTHRSEHG;KASGSGRG;RRRSLKKL;TLFPESWLWKKFT;VHRMLQAEFLQ;VLYLEKLSHKE 9 6.4 1.0031 -2.2906 0 0 10.252 8.44112 7.77821 10.2066 0 8.26299 0 9.80374 0 10.326 10.5187 10.5822 11.7604 A0A8C0P7G1 A0A8C0P7G1_CANLF BTB domain-containing protein KCND3 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion export across plasma membrane [GO:0097623]; protein homooligomerization [GO:0051260] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] A-type (transient outward) potassium channel activity [GO:0005250] AIGWMPVANCP;EDTKEYFFDRDPE;FFDRDPEVFRCV;VAFFCLDTACVM 4 6.9 1.0028 -0.72983 0 0 7.54024 0 10.072 0 0 0 0 0 9.11829 0 0 9.27326 0 A0A8C0P7G2 A0A8C0P7G2_CANLF Rap-GAP domain-containing protein RALGAPA2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] nucleus [GO:0005634] GTPase activator activity [GO:0005096] CCVCGSSTYTQQ;EQVDACKAVL;ISGKYSWDGRV;IVRQKATEVEECQQSENAPAAESGC;LNLNEPSPPPRGMN;LQTNCAEEQVLIFACLV;VDASDLKQFFETNYSQIYFIFYE;VLPNSDFLVHFYLVMHL 8 7.2 1.0039 -1.04 0 9.11975 10.3447 8.34416 0 0 0 0 0 0 0 0 0 11.027 0 A0A8C0P7L2 A0A8C0P7L2_CANLF Spectrin repeat containing nuclear envelope protein 2 SYNE2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nuclear outer membrane [GO:0005640] actin binding [GO:0003779] AEHLGEMNRQWHRVHGTL;ALPLQLLLLLLLL;ALPLQLLLLLLLLLACLL;CNLEKVQIMLQEKYSEDQHSTTLK;DILPIKRNPV;DKLYHQEKEENPDL;EEDREINKELYALLE;EKYLQSKEDLRLMLTELK;ELCAWLVQMENKVLQ;ESCKDLGPGDSG;HLDSLLQALITLKKKK;HLHRQWEDL;HNILHSIFTDLEDLSIIFETD;HQLSQDLLLWLAS;ILQQKHSMMLLENQ;IRAALPLQLLLLLLLLL;IRAALPLQLLLLLLLLLACLL;KATVKMEEYHDLLKSTEAWIEN;KDLDEYEEEKKCL;KEHEACFSEEASLYQ;LDLLEVLSG;LHDSDACANETECDSIQ;LLLLLLLL;LLLLLLLLL;LNTSIDLRTDVLND;LQQDVQKTK;QENKELMENEIQER;RNLQFHLNKMRIFEEPPFE;RVIRAALPLQLLLLLLLL;SFELSASDTQVVPEDTLTVENKKGE;SFQNMELQDHPE;SLLKELKSQGSYLLECTKNP;TQAKELNDH;VEHFSESDADDKMR;VGGSSSHEDDEEGPYYSALSD;VSKIKAILL;WTQVNQDIAEQLQKAQSLLQ 37 7.1 0.9544 0.053902 0 0 0 0 0 0 6.91456 0 0 0 0 0 0 0 0 A0A8C0P7L4 A0A8C0P7L4_CANLF Transient receptor potential cation channel subfamily M member 3 Canis lupus familiaris (Dog) (Canis familiaris) protein tetramerization [GO:0051262] membrane [GO:0016020] monoatomic cation channel activity [GO:0005261] APTDRPPSRSID;EQAMLDALVLDRV;EVFADQIDRKQV;SAFHSFESK 4 3.5 0.95284 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.88197 0 A0A8C0P7L7 A0A8C0P7L7_CANLF GRIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] AGVNNLNQ;DDIIKDSVTKMEDVYKEFEQSQR;EASAKEDEAGVNNLN;FEEQILYLQ;QKTMQELEL;QVVNEKVKHL;YEEKNTKIKQLLVKTKKELAD 7 5.5 1.0018 -2.6433 0 0 5.37945 0 6.07391 0 10.5077 11.1493 9.62372 0 10.8752 0 0 7.85375 0 A0A8C0P7M0 A0A8C0P7M0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] LLECAFMVLWLQLGWLSGEDWVE 1 16.9 0.97861 0.046279 9.53347 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P7N2 A0A8C0P7N2_CANLF Cyclic nucleotide-binding domain-containing protein PRKG1 Canis lupus familiaris (Dog) (Canis familiaris) DCMYPVEYGKD;GGGGDFGE;WPDRALLNPSSPAI 3 12.7 1.0027 -1.3488 0 0 0 0 0 0 0 10.5177 0 0 4.65243 0 0 0 0 A0A8C0P7N6 A0A8C0P7N6_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) neurogenesis [GO:0022008] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AEQKDSELNEL;DTNVTTEISGRSILSLT;ELLPCGYL;GVVRRLFKEYIIH;LASPASSHPG;LRTVKNIADLRQNLEETMSSL;LVSSTSSIYSTPEE;NAPAPLESGG;NIQGLSAEEIRNGNLKAIL;SLSNADGQYDPY;STGSTPLLRGSHSNSLIS;VERSRGGKPSSGLPQ;VLSKNIRTDDIT;YPWAASPQQHEW;YSIGEIQRSNTSETPELLPCGYLV 15 8.4 1.0045 -0.81673 12.1773 0 13.5936 11.7659 10.0951 10.3416 9.13445 0 12.9695 13.3548 11.0235 0 0 12.7056 0 A0A8C0P7N7 A0A8C0P7N7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;PRRPEAKKKKKPKTKKQNL;RLPGPQAAMT 3 11.6 0.95484 0.04941 0 0 0 0 0 0 0 0 10.5216 0 0 0 0 0 0 A0A8C0P7P7 A0A8C0P7P7_CANLF PPM-type phosphatase domain-containing protein PP2D1 Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] LSLRRRYFRRKKTRLS;VLHVANTGNVQAV 2 4.6 0.99672 -0.094181 0 0 0 0 0 0 12.9133 0 0 0 0 6.39938 0 0 0 A0A8C0P7Q6 A0A8C0P7Q6_CANLF PID domain-containing protein NOS1AP Canis lupus familiaris (Dog) (Canis familiaris) nitric-oxide synthase binding [GO:0050998] DGVKVILKKKKKLLLL;GVKVILKKKKKL;GVKVILKKKKKLL;GVKVILKKKKKLLL;GVKVILKKKKKLLLLQ;GVKVILKKKKKLLLLQK;GVKVILKKKKKLLLLQKK;GVKVILKKKKKLLLLQKKE;GVKVILKKKKKLLLLQKKEWT;ILKKKKKLLLLQ;ILKKKKKLLLLQK;KKKKKLLLLQK;KVILKKKKKLLL;KVILKKKKKLLLLQK;KVILKKKKKLLLLQKKE;LKKKKKLLLLQ;LKKKKKLLLLQKK;LKKKKKLLLLQKKE;LVMQDPIYRIFYVSHDSQDLKIFSY;VDGVKVILKKKKKL;VILKKKKKLL;VILKKKKKLLL;VILKKKKKLLLL;VILKKKKKLLLLQKK;VKVILKKKKKL;VKVILKKKKKLL;VKVILKKKKKLLL;VKVILKKKKKLLLL;VKVILKKKKKLLLLQK;VKVILKKKKKLLLLQKK;VKVILKKKKKLLLLQKKEW;VPRPNSRVEIV 32 12.1 0.98596 -0.41586 7.7498 8.28429 7.42744 9.97757 10.6322 7.82241 7.17173 14.4029 14.4123 4.84408 10.0844 5.57921 7.45533 9.6143 7.05745 A0A8C0P7R0 A0A8C0P7R0_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) LVIPKGKPQ;PEAAPEPPGL 2 9.7 1.0012 -0.93427 0 0 9.42513 8.05756 8.19111 8.15259 0 5.60122 0 9.51219 0 0 0 6.29262 0 A0A8C0P7R2 A0A8C0P7R2_CANLF Integrator complex subunit 8 INTS8 Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] nucleus [GO:0005634] ERQFWTVSNKWEVPS;IDFLLEVCSRS;LWIQVPGLCTETTPVY;MLLLDIHTHEAGTGQSGERPPSD;SELLSFIKKLREPLVL 5 8.8 0.94854 0.054665 6.48831 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P7S8 A0A8C0P7S8_CANLF Fibrillar collagen NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AAYDYCEHYSPD;DDMNYNEGFENPDQSP;DLQLCHPD;DMGPQGPRGVQGPPG;DTYYYEYPYYEDT;EAGEPGLP;EDGDKGEIGE;GAGKEEDPGIGDYDYM;GGPPGPKG;LLLLLLLL;LLLLLLLLL;LSSPPLLLLLLLL;NDEEMSYDNSPY;PDKKSEGARITSWPKEN;PGPVGEQGLPG;PGTMGPTGQVGDPGERGPPGRPGL;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PQSQDPNPDEY;PYYEDTDDPSK;VGALGLKGSEGPP 23 11.6 0.99346 -0.28406 0 0 0 0 0 9.47419 0 0 0 0 0 0 0 0 0 A0A8C0P7T3 A0A8C0P7T3_CANLF Laminin subunit beta 4 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; tissue development [GO:0009888] CDQLTGQCRCKLGYDGK;DLEEYQLHNCVE;ERCIDGYYGNPAAGKSCRPCPC;GVDHVSIRLDLEALFQFSH;HLHGCSPCDCDIGGAYSN;LLIKKLKKFL;PGAGPQDS;QPCNCHPS;SLLIKKLKKFL;VIQNLSDQVQGWKNRVS 10 7.7 1.0002 -2.8195 12.0869 3.73216 11.9388 0 0 8.30975 0 0 6.41034 7.25399 0 4.86933 0 0 0 A0A8C0P7V5 A0A8C0P7V5_CANLF Mammalian defensins domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCCGCCGGCCSVP;CCCGCCGGCCSVPVVCCCR;CCCRRSCGCSSCGCSSCGC;CCGCCGGCCSVP;CCGCGGCGGCSSGCGGCGSC;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSV;CCPCCCGCCGGCCSVPVVCCC;CCSSCCPCCC;CCSSCCPCCCGCCG;CCSSCCPCCCGCCGG;CCSSCCPCCCGCCGGC;CCSSCCPCCCGCCGGCCS;CCSSCCPCCCGCCGGCCSVP;CCSSCCPCCCGCCGGCCSVPV;CGCGGCGGCSSGCGGCGSCGG;CGCSSCGCGKGCCQQKCCQ;CGCSSCGCSSCGCGKG;CGCSSCGCSSCGCGKGCC;CGCSSCGCSSCGCGKGCCQQ;CGCSSCGCSSCGCGKGCCQQKCCQQ;CGGCGGCGG;CGGCGGCGGCGGCGGCGG;CGGCGGCGGCGGCGGCGGSCT;CGSCGGCGGCGGC;CGSCGGCGGCGGCGGC;CGSCGGCGGCGGCGGCGG;CGSCGGCGGCGGCGGCGGC;CPCCCGCCGGCC;CPCCCGCCGGCCSVP;CPCCCGCCGGCCSVPVVCCCRRSCG;CRCYRVGCCSSCCPCCCGCCGGC;CSSCCPCCCGCCGGCCSV;CSSCCPCCCGCCGGCCSVP;CSSCCPCCCGCCGGCCSVPVVCCC;CTTCRCYRVGCCSSCCPCCCG;CYRVGCCSSCCPCCCGC;CYRVGCCSSCCPCCCGCC;CYRVGCCSSCCPCCCGCCG;CYRVGCCSSCCPCCCGCCGGCC;CYRVGCCSSCCPCCCGCCGGCCSV;GCCGCGGCGGCSSGCGGCGSC;GCCGCGGCGGCSSGCGGCGSCGG;GCCGGCCS;GCCSSCCPCCCGC;GCCSSCCPCCCGCCGGC;GCCSSCCPCCCGCCGGCC;GCCSSCCPCCCGCCGGCCSVP;GCGGCGGCGGCGGC;GCGGCGSCGGCGGCGG;GCGGCGSCGGCGGCGGCGG;GCSSCGCSSC;GCSSGCGG;GCSSGCGGCGSCGGCGGCGG;GGCGGCGGC;GGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGSCT;GGCGGCGGCGGCGGCGGSCTTC;GGCGGCSSGCGGCGSCGGCGGCGGC;GGCSSGCGGCGSCGGCGGCGG;GSCGGCGGCGGCGGCGGCGGS;GSCTTCRCYRVGCCSSCCPCCCG;GSCTTCRCYRVGCCSSCCPCCCGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCG;MGCCGCGGCGGCSSGCGGCGSC;MGCCGCGGCGGCSSGCGGCGSCG;PCCCGCCGGCC;PCCCGCCGGCCSV;RCYRVGCCSSCCPCCCGCCGG;RVGCCSSCCPCCCGCCGGCC;RVGCCSSCCPCCCGCCGGCCS;RVGCCSSCCPCCCGCCGGCCSV;SCCPCCCGCC;SCCPCCCGCCGGCCSVPV;SCCPCCCGCCGGCCSVPVVCC;SCCPCCCGCCGGCCSVPVVCCC;SCGCGKGC;SCGCSSCGCSSC;SCGCSSCGCSSCGCGKGCCQ;SCGGCGGCGGCGGC;SCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGGSCT;SCGGCGGCGGCGGCGGCGGSCTTC;SGCGGCGSCGGCGGCGGCG;SGCGGCGSCGGCGGCGGCGGC;SGCGGCGSCGGCGGCGGCGGCGG;SSCCPCCCGCC;SSCCPCCCGCCG;SSCCPCCCGCCGG;SSCCPCCCGCCGGC;SSCCPCCCGCCGGCCSV;SSCCPCCCGCCGGCCSVPVVCCC;SSCGCSSCGCG;SSGCGGCGSCGGCGGCG;SSGCGGCGSCGGCGGCGG;SSGCGGCGSCGGCGGCGGCGGCG;SSGCGGCGSCGGCGGCGGCGGCGGC;TCRCYRVGCCSSCCPCCCGCCG;VGCCSSCC;VGCCSSCCPC;VGCCSSCCPCC;VGCCSSCCPCCC;VGCCSSCCPCCCGC;VGCCSSCCPCCCGCC;VGCCSSCCPCCCGCCGG;VGCCSSCCPCCCGCCGGC;VGCCSSCCPCCCGCCGGCCSV;VGCCSSCCPCCCGCCGGCCSVP;VGCCSSCCPCCCGCCGGCCSVPV;VGCCSSCCPCCCGCCGGCCSVPVV;YRVGCCSSCCPCCCGCC;YRVGCCSSCCPCCCGCCGGCCS;YRVGCCSSCCPCCCGCCGGCCSVP 120 91.2 0.86741 0.13517 0 0 0 0 0 0 3.72912 0 4.38281 0 0 0 4.35847 0 6.19298 A0A8C0P7W0 A0A8C0P7W0_CANLF Tumor suppressor candidate 3 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation via asparagine [GO:0018279] oligosaccharyltransferase complex [GO:0008250] EDRRRKRQ;SGEDRRRKRQANEEYQI;SSCCFSAS;SVSSSASSAASASPAKPQ 4 11.5 1.0032 -1.5769 0 0 12.5178 0 0 5.15656 0 0 8.27519 0 0 0 0 0 0 A0A8C0P820 A0A8C0P820_CANLF PID domain-containing protein NOS1AP Canis lupus familiaris (Dog) (Canis familiaris) nitric-oxide synthase binding [GO:0050998] GVKVILKKKKKK;GVKVILKKKKKKKE;GVKVILKKKKKKKEW;GVKVILKKKKKKKEWTW;HVKMLKYEFKAKNIKKKKVSIMVSV;LVMQDPIYRIFYVSHDSQDLKIFSY;NGEVSLSVP;RNGLKLSLS;VILKKKKKKKEWTW;VKVILKKKKKK;VKVILKKKKKKK 11 13.6 0.97856 0.035538 0 0 0 8.15416 0 0 0 0 6.34837 0 0 0 0 0 0 A0A8C0P824 A0A8C0P824_CANLF Neuralized E3 ubiquitin protein ligase 1 NEURL1 Canis lupus familiaris (Dog) (Canis familiaris) CPPVLPGG;DTVIYTCGHMCLC;GADGDGDDDDAAPAAGC;LVSQSGFWAKALPEEF;PGAVGNFHRA;SGAARPGALS 6 12.1 1.0026 -0.98599 0 0 0 8.55785 10.1114 10.527 0 0 0 10.4466 0 0 0 0 0 A0A8C0P847 A0A8C0P847_CANLF Chondroitin sulfate proteoglycan 5 CSPG5 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] membrane [GO:0016020] LLDLYDDFTP;LSVYCFCC;REAGSAVEAEEQVRSV 3 6.2 1.0021 -1.3707 0 0 0 0 0 0 0 11.4822 6.13633 0 0 0 0 0 0 A0A8C0P851 A0A8C0P851_CANLF Isochorismatase domain-containing protein 1 ISOC1 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGA;GGGGGGGG;PVLFCFSVFARPSS 3 7.6 0.94397 0.06115 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.77321 A0A8C0P866 A0A8C0P866_CANLF S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19skp1) Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] EDLGMDDEGDDD;KVIQWCTRHKDDPPS;SVTIKTMLEDLG;VIQWCTRH 4 20.6 1.0013 -0.94877 9.35021 0 0 0 8.96812 2.87403 0 0 0 0 0 0 0 0 4.52413 A0A8C0P876 A0A8C0P876_CANLF Grh/CP2 DB domain-containing protein TFCP2L1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EMVQNFQDESCFI;EQNRAPLQQ;SLCVYHAI 3 6.5 0.99331 -0.14388 0 0 0 0 0 0 0 0 0 0 13.5072 0 0 0 0 A0A8C0P886 A0A8C0P886_CANLF BEN domain-containing protein AGBL4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] DNA binding [GO:0003677] CLEPEPEL;EEDGEVKDY;KTECLYDRIAQETVDET 3 7.5 1.0027 -1.4043 0 0 0 0 0 0 0 0 0 9.87244 0 0 9.28603 9.49639 9.10575 A0A8C0P889 A0A8C0P889_CANLF PDZ domain-containing protein ACVR1B Canis lupus familiaris (Dog) (Canis familiaris) GRKRRRRRRALP;GWGWGCHV;KGGGGGGS;PASRPCAPRGCARPSTAAS;RKGGGGGG;SGRKRRRRRRAL 6 11.6 0.98743 -0.3532 0 4.89229 0 0 0 0 0 0 9.74744 0 4.29065 0 0 0 0 A0A8C0P895 A0A8C0P895_CANLF Myosin heavy chain 7B MYH7B Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AFTLVPLGSWHLQISTAHAMDI;EAAVLHNLRQRYA;EGDLKLTQESVTDAA;EIKSEATG;GVVPYSIVGWLEKNKDPLN;LLYADFRQRYRI;LTDQVSLSGKSIQ;SEATGGRV 8 5.5 0.97604 0.048034 0 0 0 0 0 0 0 0 6.43159 0 0 2.23054 0 0 0 A0A8C0P8D3 A0A8C0P8D3_CANLF ATPase V1 complex subunit H C-terminal domain-containing protein ATP6V1H Canis lupus familiaris (Dog) (Canis familiaris) "vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" CEFIQRFEMKRSP;EEKQEMLQTEG;EEKQEMLQTEGSQCAKTVIN;PASFCLWRPQRP 4 7.8 0.98565 -0.43601 0 3.88137 8.72165 0 0 0 0 0 6.11372 0 0 0 0 11.3856 0 A0A8C0P8D6 A0A8C0P8D6_CANLF ABC transporter domain-containing protein ABCF2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ANGRETTELDLLTKELED;CEKLMELYE 2 4.6 0.99167 -0.28785 0 0 0 0 0 0 10.3335 0 0 0 0 0 0 0 0 A0A8C0P8F1 A0A8C0P8F1_CANLF HS1-associating protein X-1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066] DEDEDDEEEEEEAAPWSH;FGGMTRDEDEDDEEEEE;GMTRDEDEDDEEEEEEAAPWSHGSS;PFFGGMTRDEDEDDEEEEE;SASICPLFPELPGP 5 14.9 0.9738 0.036039 6.19749 0 0 0 4.60164 0 10.129 0 0 0 0 0 0 9.5095 0 A0A8C0P8I3 A0A8C0P8I3_CANLF Small cysteine and glycine repeat containing 8 Canis lupus familiaris (Dog) (Canis familiaris) CCCRRSCGCSSCGCGCG;CCGCGGCGGCSSGCGGCSSGCG;CCGCGGCGGCSSGCGGCSSGCGGCG;CCLSCCPCCCGCC;CCLSCCPCCCGCCGGC;CCLSCCPCCCGCCGGCC;CCLSCCPCCCGCCGGCCS;CCLSCCPCCCGCCGGCCSAP;CCLSCCPCCCGCCGGCCSAPV;CCLSCCPCCCGCCGGCCSAPVVCC;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSA;CCPCCCGCCGGCCSAPVVC;CCPCCCGCCGGCCSAPVVCCC;CGCSSCGCGCGKCCQ;CGGCCSAPVVCCCRRSCGCSS;CGGCGGCGG;CGGCGSCGGCGGCGGSC;CGGCSSGCGGCGSCGGCGGCGGSCT;CLSCCPCCCGCCG;CLSCCPCCCGCCGGCC;CLSCCPCCCGCCGGCCS;CLSCCPCCCGCCGGCCSAP;CPCCCGCCGGCC;CPCCCGCCGGCCSAPVVC;CSSGCGGCSSGCGGCG;CSSGCGGCSSGCGGCGS;CSSGCGGCSSGCGGCGSCG;CSSGCGGCSSGCGGCGSCGGCG;CSSGCGGCSSGCGGCGSCGGCGGC;CYRVGCCLSCCPCCCGCC;CYRVGCCLSCCPCCCGCCGGCC;CYRVGCCLSCCPCCCGCCGGCCS;GCCGCGGCGGCSSGCGGCSSGC;GCCGGCCS;GCCLSCCPCCCGC;GCCLSCCPCCCGCCG;GCCLSCCPCCCGCCGGCC;GCCLSCCPCCCGCCGGCCS;GCCLSCCPCCCGCCGGCCSA;GCCLSCCPCCCGCCGGCCSAPVVCC;GCGGCGGCSSGCGGCSSGCGGC;GCGGCGSCGGCGGCGG;GCGGCGSCGGCGGCGGSCT;GCGGCSSGCGGCSSGCGGC;GCSSCGCGCGKCCQQKCCC;GCSSGCGG;GCSSGCGGCGSCGGCGGCGG;GCSSGCGGCSSGCGGCGS;GGCGSCGGCGGCGGSCTTCRCY;GGCSSGCGGCGSCGGCGGCGG;GGCSSGCGGCGSCGGCGGCGGSCTT;GGCSSGCGGCSSGCGGCGSCGGCGG;LSCCPCCCGC;LSCCPCCCGCCGG;LSCCPCCCGCCGGCC;LSCCPCCCGCCGGCCS;LSCCPCCCGCCGGCCSA;LSCCPCCCGCCGGCCSAP;LSCCPCCCGCCGGCCSAPV;LSCCPCCCGCCGGCCSAPVVCCCR;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCS;MGCCGCGGCGGCSSGCGGCSSG;PCCCGCCGGCC;PCCCGCCGGCCSAPVVCC;RCYRVGCCLSCCPCCCGCCGGCC;RVGCCLSCCPCCCGCC;RVGCCLSCCPCCCGCCGGCCS;SCCPCCCGCC;SCCPCCCGCCGGCCSAP;SCCPCCCGCCGGCCSAPVVCCC;SCCPCCCGCCGGCCSAPVVCCCR;SCGCSSCGCGCGKCC;SGCGGCSSGCGGCGSCGG;SGCGGCSSGCGGCGSCGGCGGCGG;SSGCGGCGSCGGCGGCG;SSGCGGCGSCGGCGGCGG;SSGCGGCSSGCGGCGSCGGCG;SSGCGGCSSGCGGCGSCGGCGG;SSGCGGCSSGCGGCGSCGGCGGC;SSGCGGCSSGCGGCGSCGGCGGCGG;TCRCYRVGCCLSCCPCCCGCCGGCC;VGCCLSCCPC;VGCCLSCCPCCCGC;VGCCLSCCPCCCGCC;VGCCLSCCPCCCGCCG;VGCCLSCCPCCCGCCGGC;VGCCLSCCPCCCGCCGGCC;VGCCLSCCPCCCGCCGGCCSAP;VGCCLSCCPCCCGCCGGCCSAPV;VGCCLSCCPCCCGCCGGCCSAPVVC;YRVGCCLSCCPCCCGCCGGCCSAP 98 94.1 1.0019 -1.2162 8.87689 10.2784 11.0142 8.53706 10.0326 8.4079 10.3115 9.41996 11.9368 7.62585 7.79779 8.39193 9.89391 11.2133 10.6968 A0A8C0P8K3 A0A8C0P8K3_CANLF Potassium channel tetramerization domain containing 1 KCTD1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] EDEDEEEE;EDEDEEEEEEEEEEEMG;EDEEEEEEEEEEEMGL;EEEEEEEEEEEMGLDW;GGLEEDEDEEEEEEEEEEE;GGLEEDEDEEEEEEEEEEEMGL;GLEEDEDEEEEE;HVIRFPLNGYCHLN;IVLDSLKQHYFIDRDGQMF;LEEDEDEEEEEEEEEE;LEEDEDEEEEEEEEEEEMG;VSPAIVSPTQDSR 12 8 0.95078 0.05734 6.00531 0 9.36986 0 8.35984 0 11.8228 5.97911 0 5.0801 5.79036 0 7.1127 0 9.63074 A0A8C0P8L3 A0A8C0P8L3_CANLF Coiled-coil domain containing 190 Canis lupus familiaris (Dog) (Canis familiaris) VMGPLYMH 1 4.1 1.0041 -1.1044 0 9.67257 0 0 0 0 0 9.16523 0 0 0 0 0 0 0 A0A8C0P8L6 A0A8C0P8L6_CANLF RAR related orphan receptor B RORB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] EVQKHQQRL;YYNVDSGQ 2 3.8 1.0021 -1.4077 0 0 0 7.95641 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P8L7 A0A8C0P8L7_CANLF ZFP69 zinc finger protein B ZFP69B ZFP69 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030]; regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HKYKIPRKRN;KPFRCKECGKAF;NLYREVMLEN;VRIHTGEKPYECGVC 4 8.8 1.0026 -0.73831 0 4.54714 0 0 0 0 9.35169 0 10.8532 0 0 0 0 0 0 A0A8C0P8M3 A0A8C0P8M3_CANLF Rho GTPase activating protein 22 ARHGAP22 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] KPFCPARRLKRNRRQ;RRQPRGGVGLREKVPANPEALLLMA 2 6.1 0.93734 0.089428 0 0 8.2116 0 0 0 0 0 0 0 0 0 0 8.0348 9.03428 A0A8C0P8M6 A0A8C0P8M6_CANLF Alkaline ceramidase (EC 3.5.1.-) ACER3 Canis lupus familiaris (Dog) (Canis familiaris) ceramide metabolic process [GO:0006672]; sphingosine biosynthetic process [GO:0046512] membrane [GO:0016020] N-acylsphingosine amidohydrolase activity [GO:0017040] IYSCCIFVYCM;LYTRTLYLRYRPKVKV 2 9.7 0.96275 0.049233 0 0 0 7.31442 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P8N0 A0A8C0P8N0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;LVESGGDLVK;VRQAPGKWL 8 22.8 1.0035 -0.80421 0 0 0 0 0 0 0 0 8.17936 0 0 0 0 0 0 A0A8C0P8N1 A0A8C0P8N1_CANLF DDHD domain-containing protein PITPNM1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] ASPDASFGKQWSSSSRSS;PLLATSSSR;SIEIETYY;SNDFIDAFASPVEA;YGPLDVVTLTGE 5 5.1 1.0032 -0.87213 0 9.69248 9.07658 0 0 8.97126 10.1317 0 0 0 0 0 0 0 0 A0A8C0P8N9 A0A8C0P8N9_CANLF Olfactory receptor LOC487457 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HVIGGVEMVLLIAM;LLLLVFSSVLYVAS;PHLHSPMY;RLACTDTYRLQ;VIYTFRNKDMKSAMKR 5 20.2 1.0033 -1.5763 0 0 0 9.0702 10.4305 0 0 0 0 0 0 0 0 15.3006 0 A0A8C0P8P1 A0A8C0P8P1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLPCHELE;GVDYTLCLSP;IQTNVTQDEWRSSHIMEVW;STKNIHIHI;VLGERTFTC 5 9.7 1.0019 -0.6698 8.4045 0 13.8948 0 0 10.5795 0 13.5752 0 0 0 0 0 0 0 A0A8C0P8P2 A0A8C0P8P2_CANLF "Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; regulation of signaling [GO:0023051] plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DGDLQLWG;DPRGPGAAAPGSGP;DSFPLWDLP;EDQEDSGHDTMSYRDSYSECNS;EINTQSLEKVQQYY;GSANETIGQEDRGLSF;LLSTITEPTSGGSCDPP;LPSRLEGGASL;NNIRTMFHYEFRN;QEDREIQGAYL;VLEHFQAFRSHQEEALGLYQWV;WHPVPSQGSNLTD 12 9.6 1.0035 -1.6166 8.81551 0 8.65148 7.8315 0 0 7.07232 13.085 0 9.17303 0 7.88393 0 12.1878 0 A0A8C0P8P4 A0A8C0P8P4_CANLF Non-specific protein-tyrosine kinase TNK2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; regulation of keratinocyte differentiation [GO:0045616]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713] GEKDLHLFEKL;LEAQPTDMRAL;LLEAQPTDMRALQDFEE;PCILPIVRDG;TLWEMFTYGQ;VIQAPGPRAGP 6 6 1.0018 -1.309 0 0 6.81596 0 0 0 0 10.0925 0 0 0 0 0 0 11.3064 A0A8C0P8S1 A0A8C0P8S1_CANLF Leucine rich repeats and IQ motif containing 1 Canis lupus familiaris (Dog) (Canis familiaris) AWLCNENENLFSSEHAQF;DIATAQQML;DILSKYNYSY;EILRCGPWNTLQ;EWHTEEYYQPELA;FTFDEAAL;GKEEELTYKDATA;LKRAQKMKSKKLRK;LQDLEDTDILS;QGNYLTELPSL;SKEYTYQWLHTQVGIHETT;WLCNENENLFSSEHAQF 12 8.4 1.0026 -1.8985 15.1798 11.7277 11.5562 9.7912 2.56101 0 0 6.85175 10.1349 13.4522 0 15.2261 14.3458 11.9003 10.8981 A0A8C0P8U2 A0A8C0P8U2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;GVLPNSFYEASIALIPKPDK;LSLFANDMILYVENPKVSTP;MDAFLESHKL;MNEKGEITTNT;RMGNINKAGNNKCW 6 6.9 0.99084 -0.19446 0 0 0 9.56661 0 0 0 6.75235 0 0 0 0 0 0 0 A0A8C0P8W8 A0A8C0P8W8_CANLF Collagen IV NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] EGGGQSLV;GAPGFPGP;GTPGRDGLPGLPG;GVPGFSGLPGELGLKGMRGEPG;HYFANKYSFWLTTVEERQQFREEP;LEDFRATPFIECSGARGTC;PGPRGLPGDQGIDG;PSSNQGDPGDP;SGKAGHAG;VGLVGFPG 10 10.2 0.98506 -0.25787 0 9.25321 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P8Y0 A0A8C0P8Y0_CANLF ATP binding cassette subfamily B member 11 ABCB11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] FDTLVGEGGGQMSGGQKQRV;LVIMCFFPFL;NTRFSDDINRVNDAI;TAVVGSSGSG;TGFMWCLIFLCYALAFWYGSKLVL;VERGSHEEL;VGFFQLFRF;VGFFQLFRFSSTTDI;VSKFTDYELKAY 9 9.1 1.0029 -2.1906 0 0 14.243 0 7.87129 9.09255 10.8104 0 0 0 0 0 11.1062 9.69504 10.7782 A0A8C0P8Z4 A0A8C0P8Z4_CANLF Mucin-5AC Canis lupus familiaris (Dog) (Canis familiaris) ACDSGGDCECFC;CGSPCADTCSNPEHSQLCEDHC;CVGDACACDSGGDCEC;DACACDSGGDCECF;DIQLVPIMQVFVRL;DSGGDCECFCT;DTCSNPEHSQLCEDHCM;EACVGDACACDSGGDCEC;GDACACDSGGDCECF;GDACACDSGGDCECFC;LDELGQDVICDKS;LPPSLLSSGVSSIHPPRTC;NCMFDTCN;NCMFDTCNCEKSEDCL;PEYITQLECRAE;PPVKVTDHDDCCPNYQCQCVCSGW;PTVGLVCYNRNQ;SSPMSHKTSVQPHVTCGEECL;TWPLDECWCPTCSLCSGP;VGDACACDSGGDC;VGDACACDSGGDCEC;VGDACACDSGGDCECFCTA;VGDACACDSGGDCECFCTAV;VTDHDDCCPNYQCQC;VTENVPCGTTGVTCSKAIK;YSNCMFDTCNCEKSEDCLC;YYNPEGQC 27 6.1 0.98408 -0.24433 0 0 0 7.30095 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P917 A0A8C0P917_CANLF Ankyrin repeat domain 13A ANKRD13A Canis lupus familiaris (Dog) (Canis familiaris) late endosome [GO:0005770]; plasma membrane [GO:0005886] LLESSRSQE;LSARELEERE;SHTLPCFDIIYAIIYMPV;TVLHEAVSTGDPEM;YEIMQFAIQQ;YTVLQHRDYHN 6 12.1 0.97931 0.048313 7.35887 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P919 A0A8C0P919_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macrophage activation [GO:0043031]; regulation of immune response [GO:0050776] membrane [GO:0016020] cell-cell adhesion mediator activity [GO:0098632] LLSIVSLVILLVLISILLYWKRRRN;LSIVSLVILLVLISILL;LTVYMDHPLR 3 12.7 0.94301 0.081765 8.31329 0 0 0 0 0 0 6.09261 0 0 0 0 0 0 0 A0A8C0P922 A0A8C0P922_CANLF "Lipase F, gastric type" LIPF Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] DAGYDVWLGNSR;VLSSKRTFYTMTQAAPEG 2 5.9 0.98832 -0.26453 0 0 0 0 0 0 0 0 0 8.41409 0 0 0 0 0 A0A8C0P928 A0A8C0P928_CANLF Ferritin Canis lupus familiaris (Dog) (Canis familiaris) intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826] cytoplasm [GO:0005737] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198] ALQGINLELYASYVYLSMS 1 20.2 0.95234 0.049882 0 0 0 0 0 0 0 6.54683 0 0 0 0 0 0 0 A0A8C0P932 A0A8C0P932_CANLF DUF4614 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHDMLKQQLNLTQQFLE;DLAPAVSEN;LLKDKAVVEGWRSLSSG;SESRAHPEESPDRMLDT 4 9.6 0.97906 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.34072 0 0 A0A8C0P971 A0A8C0P971_CANLF Proline rich acidic protein 1 Canis lupus familiaris (Dog) (Canis familiaris) AATWATWQGSEAQA;DRDSLYHPLPEEAQGPARLWPWVL 2 22 0.98779 -0.36836 11.1385 5.74865 0 0 0 9.97039 5.52206 16.8716 16.9333 0 0 0 0 0 7.22757 A0A8C0P980 A0A8C0P980_CANLF Sulfotransferase (EC 2.8.2.-) SULT1C2 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] lysosome [GO:0005764] aryl sulfotransferase activity [GO:0004062] EFKCHPDTSFHS;HVKGWWEIKDRYQI;QETSFEKMKENPMVNRSTVP 3 13.9 0.95326 0.05044 0 0 0 0 7.38595 0 0 0 0 0 0 0 0 0 0 A0A8C0P984 A0A8C0P984_CANLF glutathione-disulfide reductase (EC 1.8.1.7) Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; glutathione metabolic process [GO:0006749] membrane [GO:0016020] flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADPH) activity [GO:0004362]; NADP binding [GO:0050661] LLWLLFFFFFF;RPQESQIP;THVLLLWLLFFFFF 3 4.7 0.98531 -0.24109 0 0 0 0 0 0 0 0 0 0 4.47923 0 0 0 0 A0A8C0P993 A0A8C0P993_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDYCNSPSS;PDSSSDSDYEHYDFS 2 5.9 0.99087 -0.26894 0 0 0 0 0 7.29948 0 0 7.1979 0 0 0 0 0 0 A0A8C0P9A1 A0A8C0P9A1_CANLF Zinc finger and BTB domain containing 41 ZBTB41 Canis lupus familiaris (Dog) (Canis familiaris) AEEDELEEEMS;CDKTFDRI;DELEEEMSDEYSDIE;ICGKSVRERTTLKEHLRIHSGEK;LERSFSTRRSKRNRKCPVKFDDTS;LSPQPQSTDYPRAADLA;NDSEDPGSEYN;TSEEKLVSLP 8 12.2 1.0025 -1.7498 9.00014 0 9.2022 0 8.67832 0 0 0 9.08969 0 0 0 0 9.25765 9.18621 A0A8C0P9A5 A0A8C0P9A5_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GGGRTTGGE;SERRGGGRTTG;WVAVVFPL 3 3.6 1.0033 -1.0346 0 9.76505 0 0 0 7.00529 0 9.27722 0 0 0 0 0 0 0 A0A8C0P9B0 A0A8C0P9B0_CANLF TFIIE beta domain-containing protein GTF2E2 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase II promoter [GO:0006367] transcription factor TFIIE complex [GO:0005673] DNA binding [GO:0003677]; TFIIH-class transcription factor complex binding [GO:0001097] IVNYMKTRHQRGDTHPLTLE;VLAKIVNYM 2 8.9 0.98566 -0.241 0 0 0 0 0 0 0 0 9.83963 0 0 0 0 0 0 A0A8C0P9B6 A0A8C0P9B6_CANLF Protein AMBP Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] AVLPQEEE;AVLPQEEEG;KKKKKARRGS;PVGGPPAG;VGGTSGPA 5 8.4 1.0041 -1.9805 8.07655 8.65546 0 0 0 0 0 0 0 0 0 4.87892 0 0 0 A0A8C0P9E5 A0A8C0P9E5_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] AKYEEEAHKH 1 2.4 0.99884 -0.61146 0 0 9.5504 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0P9E6 A0A8C0P9E6_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755] plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; protein-hormone receptor activity [GO:0016500] QSRSPSCTRSRSP;YAYQCCAFWGCD 2 2.5 0.98985 -0.22037 0 0 10.3108 0 0 0 0 0 0 0 7.57856 0 0 0 0 A0A8C0P9F3 A0A8C0P9F3_CANLF Collagen type XI alpha 1 chain COL11A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix structural constituent [GO:0005201] AAYDYCEHYSPD;AFPEDFSI;AKGEAGAEGPPG;DYCEHYSPDCDSSV;EAGTGGPK;EDGDKGEIGE;GVGGDKGEDGDPGQPGPPGPS;IDEYAPEDIMEYDYEY;MLIEGPPGPAGPAG;MLPFRYGGD;PGPPGPPGEVIQPLPILSPKKTR;PGPVGEQGLPG;VGEKGEPGEAGNPG;VGPMGPPG 14 10.1 1.0031 -2.2614 7.49897 0 9.79615 11.5906 12.743 10.4257 0 11.1951 4.46035 8.56094 7.46082 0 9.72042 11.5557 0 A0A8C0P9G9 A0A8C0P9G9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;LYPQKYRTLL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TLGAFPLR 6 6.7 0.98761 -0.35313 0 9.98883 10.8896 0 0 0 0 0 0 0 0 0 0 7.67638 0 A0A8C0P9H4 A0A8C0P9H4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDEDDYYCA;QPEDEDDYYCALGLTWDMDLSAH;TVVTQEPSL 3 23.7 1.0028 -0.75796 0 0 7.31587 0 0 0 0 0 0 0 0 0 0 5.58415 8.45668 A0A8C0P9I7 A0A8C0P9I7_CANLF procollagen-proline 3-dioxygenase (EC 1.14.11.7) P3H1 Canis lupus familiaris (Dog) (Canis familiaris) collagen metabolic process [GO:0032963] endoplasmic reticulum [GO:0005783] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" VTRGQRCAIALWFT;YLEYNADLFQAIADH 2 4 0.9197 0.11483 0 0 0 0 0 7.0009 9.83116 0 0 0 0 0 0 6.916 0 A0A8C0P9J3 A0A8C0P9J3_CANLF Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) NR0B1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] cytoplasm [GO:0005737]; nucleus [GO:0005634] AGLLKTLRFVKYLPCFQV;LDQQLVLV;PQPPPLVPP 3 7.4 1.0022 -1.8603 8.10093 0 0 0 0 0 0 8.27864 0 0 6.03281 0 0 0 0 A0A8C0P9J6 A0A8C0P9J6_CANLF Acetylcholine receptor subunit delta Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] EVEETLTTNVWIEHGWTDSRLQWD;PAEDGPSP 2 6.2 1.0021 -1.3959 0 0 12.4126 0 7 0 0 0 0 0 0 0 0 0 0 A0A8C0P9K1 A0A8C0P9K1_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; immune response [GO:0006955]; regulation of programmed cell death [GO:0043067]; signal transduction [GO:0007165] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] EVERNLGHKRPHHPGFPVPLF 1 7.1 0.95377 0.049851 0 0 0 0 0 0 0 0 0 0 10.3144 0 0 0 0 A0A8C0P9L2 A0A8C0P9L2_CANLF Rho family GTPase 1 RND1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AIAKQLGAEIYLEGSAFTSEKS;ETYVPTVFENYTACLE;GCKTDLRTDLSTLMEL;VCLNKPSP 4 26.7 0.98959 -0.22006 0 11.1013 0 9.47804 10.2593 9.48257 11.8554 12.0333 11.4993 11.1164 11.3751 11.6898 11.2626 0 0 A0A8C0P9Q2 A0A8C0P9Q2_CANLF Heat shock-related 70 kDa protein 2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] AEKDEYEHKQ;AMNPTNTIFDAKR;EDEKLRGKIS;GGGGGGSG;GRLSKDDIDRMVQE;GVDFYTSITRARFEEL;TTIPTKQTQTFTTYSDNQSSVL 7 15.1 1.0019 -1.3084 9.05173 0 0 0 8.6726 8.57478 0 0 0 0 7.02868 10.5118 0 0 0 A0A8C0P9Q8 A0A8C0P9Q8_CANLF Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" EEVFISPFPSG 1 3.1 0.98706 -0.23001 0 0 0 0 0 0 0 0 10.0523 0 0 0 0 0 0 A0A8C0P9R6 A0A8C0P9R6_CANLF VWFA domain-containing protein COL6A2 Canis lupus familiaris (Dog) (Canis familiaris) ENARYLNSFSHVG;EQQVEFPLTSNLTVIHQALENARYL;FAVVVTDGHVTGSP;FSPPDSDRASFTK;GAKGSPGVNGP;LDVVFVIDSSES;MTYVRETCGCCDC;PNQSPNEQGLRD;VKGAKGGP;YGECYKVSCLEIP 10 12.9 1.0023 -1.4585 0 0 0 11.66 8.28674 10.425 8.13981 9.15914 0 0 9.37777 0 0 0 9.94089 A0A8C0P9S0 A0A8C0P9S0_CANLF "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3)" ACO2 Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; metal ion binding [GO:0046872]" AKQALAHGLKCKSQ;DLLEKNIDIVRKRLNRPL;PGKPLKCI;SGLPKVAVPSTIHCDHLIEAQ 4 7.8 0.99272 -0.069382 0 5.38716 9.79383 0 0 8.81586 0 0 0 0 0 0 0 0 13.4629 A0A8C0P9V3 A0A8C0P9V3_CANLF Transcription elongation factor A2 OPRL1 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] membrane [GO:0016020]; nucleus [GO:0005634] nociceptin receptor activity [GO:0001626]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] TKEAIREHQMARTG;VGARAGGVRGLPRGPA;VGGARGGGGGA;VGHTGTPRRGRGLEGTLLC 4 7.6 0.99687 -0.087905 0 8.91773 4.61265 0 6.57808 0 0 0 0 0 0 0 5.14841 0 0 A0A8C0P9W7 A0A8C0P9W7_CANLF Hedgehog protein DHH Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; osteoblast differentiation [GO:0001649]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autoprocessing [GO:0016540]; regulation of steroid biosynthetic process [GO:0050810]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; patched binding [GO:0005113]; peptidase activity [GO:0008233]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] TEGWDEDGHHAQDSLHYEG;VGRRRYVRKQLVPLLYKQF;VKADNSLAVRAGGCFP;WDEDGHHAQDSLHYEG 4 13.6 0.99581 -0.11624 4.04972 0 7.15997 0 0 0 0 0 0 0 8.35843 8.03749 0 0 7.84392 A0A8C0P9X2 A0A8C0P9X2_CANLF VWFD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CDYYNTHTHEDGAYQYNQDANCTWH;CGCDTTGDCEC;CGCDTTGDCECL;CVQDACGCDTTGDC;ISTAPDRGWCST;KGVCVDWRTPDFCPIYCDYY;LLPEPPLP;TDGCGANN;TFGAACAP;VLDDISRN;VYQACNYEK;YEACVQDACGCDTTGDCECLCDA 12 8.8 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 6.79351 0 0 A0A8C0P9X3 A0A8C0P9X3_CANLF Transcriptional adapter TADA2A Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; SAGA-type complex [GO:0070461] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] PCRGCSSYLMEPY 1 3.2 0.93739 0.059735 0 0 0 0 0 0 7.12928 0 0 0 0 0 0 0 0 A0A8C0P9Z3 A0A8C0P9Z3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CDLTSRSQPSSV;DEKSLEFTPDPK;DPSPQTQVVKS;EESENSLSFESQHSLKPSYL;EFLARPMKQDMKSLE;ERRCRSPSERSHRSTSQKSHHI;IQNLFGVPAELMKP;ISSSTSSVFV;ITGAKRHV;KSVPLTPGPR;KTDFSEQFQLLQDL;LDLQVPESVDRTPV;LEKSNLLEDLAALSPLRSQSSVFES;LQDIQSVGFE;LTSEPKHQ;PVALGSPMGMIIASQS;QDTKSVELAPG;QDVRFSDL;QSQIVETPDLTSRP;SMVFNPDR;TEFNFGPQLQNV;TPQPYHQRTETMAL;TSASLRRQ;VDQLILRPLQEDM;VGGRNLHGSPHRTS;VGHTESVELT;VGLTSRQWLQRRQ;VGPQFKVAESV;VRPSEFTSELWLQ 29 6.6 0.99218 -0.29525 0 0 0 8.4876 0 0 0 0 0 0 8.92089 0 11.5975 0 0 A0A8C0P9Z8 A0A8C0P9Z8_CANLF Small integral membrane protein 19 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] STAPGTTGP;YSISRKYDYQQPQNQ 2 8.5 0.98272 -0.25143 0 0 0 0 0 0 0 0 0 0 8.88001 0 0 0 0 A0A8C0PA11 A0A8C0PA11_CANLF E3 ubiquitin-protein ligase PPP1R11 (Protein phosphatase 1 regulatory subunit 11) PPP1R11 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865] ESDEEEEEGCGH 1 16.2 0.9533 0.05044 0 0 0 0 0 0 4.76771 0 0 0 0 0 0 0 0 A0A8C0PA12 A0A8C0PA12_CANLF PCI domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) COP9 signalosome assembly [GO:0010387] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] VGCEVVLSGIEEQ 1 5.2 0.93415 0.068343 0 0 0 0 0 5.05697 0 0 0 0 0 0 0 0 0 A0A8C0PA20 A0A8C0PA20_CANLF EWS RNA binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] FAWRTECNQCGD 1 1.9 0.95207 0.05044 0 9.71564 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PA37 A0A8C0PA37_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CAFYARLCPGPAAACARLAQ;EEANGCPG;LLLLLLLP;LLLLLLPL;MLLPVLLLLLLL;PKRRPEQRE 6 8.3 1.0029 -1.5071 0 0 9.67124 0 9.7969 6.78202 0 0 0 0 0 0 0 0 0 A0A8C0PA46 A0A8C0PA46_CANLF Zinc finger BED-type containing 9 SCAND3 Canis lupus familiaris (Dog) (Canis familiaris) DNA integration [GO:0015074] nucleus [GO:0005634] nucleic acid binding [GO:0003676] FSKAKYCQL;HWAEFLWFIQMTQNQPYHRGMQQI;LLVLEQFLTILPEELQ 3 3.7 0.99138 -0.27211 0 0 9.07478 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PA82 A0A8C0PA82_CANLF Solute carrier family 24 member 3 SLC24A3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane transport [GO:0070588] membrane [GO:0016020] antiporter activity [GO:0015297] AGLRIMIT;DVVAEAGNETENENEDNENNEND;EAGNETENENEDNENNENDEEEE;EDNENNENDEEEEEDEDDD;EEEEEDEDDDEG;ENENEDNENNENDEEEEEDEDD;IVARQGMGDMAV;LHLSEDVAGATFMAAG;NEDNENNENDEEEEEDEDDDEGP;TWPLSFVLYFT;VTFASSTLWIAAF;WLCFPSALH 12 17.9 0.99068 -0.21092 0 0 0 0 0 0 0 0 0 0 0 8.48913 0 0 0 A0A8C0PA85 A0A8C0PA85_CANLF Anoctamin ANO10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ECNDNTMRAFTYGTRHNFKDY;IPMAVIGLPYYL;LLPYWLQKKHHVRVRRKVQALKAD;RLYRYAAEFL;RWGTLVMKRQFEEPRPG 5 13.7 1.0023 -0.76547 5.92588 0 6.68004 0 0 5.68488 0 0 0 0 0 0 0 0 0 A0A8C0PA86 A0A8C0PA86_CANLF Protein tyrosine phosphatase receptor type N2 Canis lupus familiaris (Dog) (Canis familiaris) secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] protein tyrosine phosphatase activity [GO:0004725] HFLSWYDQGVPSSARSLLD;PGLLGCLFQDDLCSS;PLSENGVRQ;PPGDPKNPPALGDEALIQ;VLTLVSVVAMV;YHVYEVNLVSEHIWCEDFLVR;YMEDHLNNKN 7 10.4 1.0033 -1.5149 0 0 0 0 0 0 0 9.56976 0 10.4542 0 0 0 8.97464 0 A0A8C0PA94 A0A8C0PA94_CANLF "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256)" Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] endoplasmic reticulum membrane [GO:0005789] "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [GO:0106073]" VITLVSLFLVWKFTYAHK;WIFGWSEHVVCSIGML 2 7.2 0.93587 0.097546 0 0 0 0 0 0 0 0 0 0 0 9.67543 0 6.30402 0 A0A8C0PAA0 A0A8C0PAA0_CANLF 60S ribosomal protein L29 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] AAIPAPAPAPTPTAQ 1 9.3 0.99673 -0.096007 0 0 0 0 0 0 0 11.9409 0 0 0 0 0 0 0 A0A8C0PAB0 A0A8C0PAB0_CANLF Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) F7 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] KNWKNLTGEHD;LDRGATAL;VGGKVCPKGECPWQ;VLTGTPPQ;YTDHVVPLCLPEKTF 5 12.6 1.0028 -1.193 0 0 0 4.43476 8.48148 0 0 0 0 0 0 0 0 0 0 A0A8C0PAB3 A0A8C0PAB3_CANLF Claudin CLDN23 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] structural molecule activity [GO:0005198] YLEAAPVRA 1 3.5 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 9.99209 0 4.613 A0A8C0PAC6 A0A8C0PAC6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" CQKTFRYCSDLNRHKNIHTKE;EERQLYKDVML;HVRKKYYTCNYCKKDFRPYS;NLILHQKSHTRKKL 4 12.8 0.9885 -0.47468 8.64317 0 0 0 0 0 0 0 0 0 0 0 10.1349 8.2903 0 A0A8C0PAE9 A0A8C0PAE9_CANLF Spindle and kinetochore-associated protein 3 Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer kinetochore [GO:0000940] SEVQTLKDDVSILLDQTSLE;SKGFLTKY;VISSYENLLRT 3 8.4 1.0028 -1.536 0 0 0 0 0 8.74379 0 0 11.6104 0 0 0 0 0 0 A0A8C0PAF0 A0A8C0PAF0_CANLF Notch receptor 3 NOTCH3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; developmental growth [GO:0048589]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023] AAAQTGVRLEE;AAGAHGSP;CQTGGQCVDKDNSHYCVCPEG;DNCEDDVDECA;GVGSFSCS;KYCADHFADGRCDQG;LLPLLAASAVFLLVILVL;LTPSPESPEHWASPSPPSLSDWS;LVARYLCSCPP;LVDWCSRAPCQ;RRRRPMSPPPPLPP;RSPHGPHGLGPLLCP;SCPPGTLGVLCEINEDDCGP;SLDSPRPFGGP;TCICMAGFTGTYCEV;TCQGYMGGYVCECPAGYTGDNCEDD;TLCERNVDDCSPDP;TYCEVDMDECQ;VPLLPLLAASAVFLLVILVL;YSGPSCDQDIDDCDPNPCLNGG;YTGDNCEDD 21 11.7 0.99894 -3.1392 0 7.39403 11.3092 9.52066 0 0 9.05129 8.22622 14.232 7.74207 0 7.09866 8.14241 9.26643 0 A0A8C0PAG8 A0A8C0PAG8_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CSDCGKAFIHSSH;IFFLIFYLFIHERHRERERQRHRQR 2 8.8 0.92387 0.095109 0 0 0 0 0 0 0 0 0 0 0 0 0 6.90629 7.06091 A0A8C0PAH1 A0A8C0PAH1_CANLF "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit)" LOC119864881 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]" mitochondrial respiratory chain complex I [GO:0005747] "4 iron, 4 sulfur cluster binding [GO:0051539]; NADH dehydrogenase activity [GO:0003954]" AIVEGPNFEFSTETHEELLY;CPVDAIVEGPN;TETHEELLYNKEKLLS 3 48.4 0.8819 0.1387 0 0 7.24812 0 0 0 0 0 0 6.09906 0 0 0 10.443 6.31444 A0A8C0PAH4 A0A8C0PAH4_CANLF Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 NYAP2 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] AALGPAAAAASALSS;GGTDDDNS;PSPVSMGRSLTPLSL;QAGASPSS 4 7 0.98616 -0.24577 0 0 0 0 0 0 0 0 0 0 0 0 8.32328 0 0 A0A8C0PAI0 A0A8C0PAI0_CANLF BCL6 corepressor like 1 Canis lupus familiaris (Dog) (Canis familiaris) CVSSSFSKVEL;FAGMADSDMGSQEVFPTEEE;GLVKRKKRRRQKSRK;LVKRKKRRRQKS;LVKRKKRRRQKSRKY;NQGPEESESHLC;QEGDDVEEDDFMF;VLAPMPASTPPAAPAPPSVP 8 5.7 0.93872 0.10304 9.79181 0 0 0 5.87558 0 11.1139 7.20359 0 8.11863 2.50957 7.97648 0 0 8.12748 A0A8C0PAI1 A0A8C0PAI1_CANLF PHD-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] EEDDDDDTM;FSPDPLPP;LLCDAGTAIGGGKAEGD 3 4.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.93546 A0A8C0PAI3 A0A8C0PAI3_CANLF Regulating synaptic membrane exocytosis 2 RIMS2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] membrane [GO:0016020] small GTPase binding [GO:0031267] DDEDVDSRDEYERQRREEEYQARY;EPHWYKLQTHDVSSLP;GVCIAKKKTKVARKTL;LVDPTLAPLTRRASQ;RMDHKSFMG;VLSHFHGVFSSPP 6 7.8 0.99743 -0.098851 0 0 0 0 0 0 0 0 0 0 0 9.84721 0 0 0 A0A8C0PAJ0 A0A8C0PAJ0_CANLF TGF-beta family profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] extracellular region [GO:0005576] growth factor activity [GO:0008083] CVPTRLTPISI;HVNFKELGWDDW 2 5.3 0 1.5776 12.7242 13.0912 12.8012 0 10.0598 9.88183 0 13.221 13.3178 12.8601 12.9328 0 12.9056 12.657 12.8597 A0A8C0PAL1 A0A8C0PAL1_CANLF Gap junction protein GJB2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; gap junction assembly [GO:0016264]; gap junction-mediated intercellular transport [GO:1990349]; sensory perception of sound [GO:0007605] connexin complex [GO:0005922] calcium ion binding [GO:0005509]; gap junction channel activity involved in cell communication by electrical coupling [GO:1903763]; identical protein binding [GO:0042802] KFIKGEIKSEFKDIE;YVMYDGFSMQRL 2 11.9 0.98908 -0.30223 0 0 0 13.1411 0 0 0 0 10.448 0 0 0 0 0 0 A0A8C0PAM6 A0A8C0PAM6_CANLF Pro-apoptotic WT1 regulator Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] AECLDEYE;EQLKQENKTLLKVVGQLTRVKI;RGKGAGPS 3 9.6 1.003 -2.1621 0 0 0 0 0 0 4.9465 0 0 0 0 0 0 0 11.6694 A0A8C0PAM7 A0A8C0PAM7_CANLF NF-kappa-B essential modulator NEMO CC2-LZ domain-containing protein TNIP3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of canonical NF-kappaB signal transduction [GO:0043122] cytoplasm [GO:0005737] CRHEEMRTEMEVLKQ;KENKLLKEKNALISKKKE 2 9.9 0.94262 0.1022 6.87799 0 0 0 0 0 0 0 0 0 0 0 0 0 9.48995 A0A8C0PAN9 A0A8C0PAN9_CANLF Myb-like domain-containing protein PRDM11 Canis lupus familiaris (Dog) (Canis familiaris) DFWFCESCQEYFVDECPN;RVGQMCQTLTEIRD;VLFGRETM 3 7.8 0.98826 -0.3471 0 0 0 0 12.411 12.3993 0 0 0 0 0 0 0 0 0 A0A8C0PAR6 A0A8C0PAR6_CANLF Cystatin domain-containing protein CST11 Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829] cysteine-type endopeptidase inhibitor activity [GO:0004869] MQYLSDDFNKKSNDKYNF;QKQITDHMEFHVNME;QKQITDHMEFHVNMEMRRTTCQ 3 29 0.99272 -0.16563 0 0 0 0 5.93423 0 0 0 0 0 3.41265 9.52769 11.7245 0 0 A0A8C0PAT9 A0A8C0PAT9_CANLF Large ribosomal subunit protein bL21m Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] AEETRHHAEVVGKV;AQTTCCCCCCC;AQTTCCCCCCCC;AQTTCCCCCCCCCF;AQTTCCCCCCCCCFSRAG;CCCCCCCCCFSRA;CCCCCCCCCFSRAG;CCCCCCCCCFSRAGFP;CCCCCCCCF;CCCCCCCCFSR;CCCCCCCCFSRAGF;CCCCCCCCFSRAGFP;CCCCCCFSR;CCCCCCFSRAGFPPRQ;GGPKAQTTCCCCCCCCCFS;GGPKAQTTCCCCCCCCCFSRA;KAQTTCCCCCCCCC;KAQTTCCCCCCCCCFSRA;PKAQTTCCCCCCCCCF;QTTCCCCCCCCC;QTTCCCCCCCCCF;QTTCCCCCCCCCFS;QTTCCCCCCCCCFSR;TCCCCCCCC;TCCCCCCCCCF;TCCCCCCCCCFSRA;TCCCCCCCCCFSRAGF;TTCCCCCCCCC;TTCCCCCCCCCF;TTCCCCCCCCCFS;TTCCCCCCCCCFSR;TTCCCCCCCCCFSRAG 32 8.4 0 1.3597 10.9516 7.94667 8.50291 9.3552 6.68356 8.94764 7.15046 8.67754 7.84593 5.07442 4.22018 6.63407 7.63132 7.52888 7.80187 A0A8C0PAU3 A0A8C0PAU3_CANLF Inhibin beta B chain (Activin beta-B chain) INHBB LOC119870005 Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; apoptotic signaling pathway [GO:0097190]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; response to wounding [GO:0009611] cell periphery [GO:0071944]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803] AYLAGVPG;FRRPEELGRVD 2 4.7 1.0039 -1.0689 0 11.8847 0 0 0 0 9.85639 0 0 0 0 0 0 0 0 A0A8C0PAV3 A0A8C0PAV3_CANLF Plexin cytoplasmic RasGAP domain-containing protein PLXND1 Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor activity [GO:0017154] IKKKKKKLITRQ;LLYIKKKKKKLI;LLYIKKKKKKLITRQL;YKYAKRYRTQLLYIKKKKKKLITR 4 44.1 0.99188 -0.18376 4.12582 4.16036 7.62213 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PAW3 A0A8C0PAW3_CANLF IF rod domain-containing protein KRT86 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] LEGEEQRRQQLPRWRRLWRSLRL;LEPLFEGYIETL 2 7.4 0.97834 0.046253 0 0 0 0 0 0 0 0 0 0 7.65514 0 0 0 0 A0A8C0PAW9 A0A8C0PAW9_CANLF Crumbs cell polarity complex component 1 CRB1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] ELNIDECFSNPCIH;GVCYSLWDDFSCSCPAN;ITLEDISSSSSLNVK;KAGCERKDWCERQ;RDANVIILH;SGLLLALEN;YSGYTGAQCETHINECNGNPC 7 7.5 0.98535 -0.25327 0 8.69589 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PAY0 A0A8C0PAY0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATSTATLYVEARHIE;DPTMVVEWL;HYLGKKVKHRII;IDLEVFEMPPRFIMPIC;ISELDQFYT;KLGDRNLPLPG;KTEIGASSRYITAINKNEELYET;KVAEHPQRPAS;LLSSQTWKEYEVEEREQE;PSRFFRMTQFED;RYTTPPGEALERYATPPGEALERY;VLCSREEIEGRFVSD;VTWFQNGLLLKQDQ;YESLMKSQ 14 3.6 0.97071 0.041303 0 0 0 8.98391 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PAZ9 A0A8C0PAZ9_CANLF HTH psq-type domain-containing protein LCOR Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] GAPGGAGR;GGGGGGGG;KKKMKLMRS;LGTLKNPPKKKMKLM;SKKLRAILPKQNRKSM;SLFKDCERESISDWTF;TESALSKKL 7 10.1 1.0019 -1.2726 8.42059 0 0 0 0 9.28882 0 8.68734 0 0 0 0 4.50589 7.22294 0 A0A8C0PB08 A0A8C0PB08_CANLF Lamin B1 LMNB1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652] structural molecule activity [GO:0005198] PLSPTRLSRLQ;RLKNTSEQDQPM;SYKYTSRYVLK 3 6.3 0.99233 -0.19181 0 0 0 8.46854 0 0 9.91103 0 0 0 0 0 0 0 0 A0A8C0PB09 A0A8C0PB09_CANLF Non-specific serine/threonine protein kinase RPS6KA3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] FEMLTGTLP;SEDLRRGQNGQ;VRTKMERDILV 3 4.4 0.99416 -0.19102 0 0 0 0 0 10.5829 0 0 0 0 0 0 0 0 0 A0A8C0PB66 A0A8C0PB66_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitotic spindle assembly [GO:1901673] blood microparticle [GO:0072562]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; ubiquitin protein ligase binding [GO:0031625] LEPVEKALRDAKLDKA;MVLTKMKEIAEAYLGYPV;PGAGGFGAQAPKGG;QEAEKYKAEDEVQRDRV;VLIQVYEGE 5 12.9 0.99744 -0.10272 9.30615 0 9.7686 8.53181 9.20682 0 0 0 0 0 2.23116 10.2624 0 0 0 A0A8C0PB80 A0A8C0PB80_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GADASESVED 1 8.5 0.99978 -0.61146 0 0 0 0 0 0 0 0 0 0 9.74937 0 0 0 0 A0A8C0PB83 A0A8C0PB83_CANLF EF-hand domain-containing protein EFHD1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DEDFDGRLSFREFLLIF;ELKAEQDERKQEEEK 2 13.2 0.98643 -0.45557 0 0 11.0146 0 0 0 0 0 10.1518 0 0 0 0 0 0 A0A8C0PB85 A0A8C0PB85_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) ACVR1B Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363]; nervous system development [GO:0007399] activin receptor complex [GO:0048179] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]" EDPSCEMC;GGGGGGGA;GGGGGGGG;IKLALSAASGLAH;LDMEDPSCEMCLSKD;PGGGGGGG;PVFLLFLIIIIVFL;PVFLLFLIIIIVFLV;VGIIAGPVFLLFLIIIIVFLVI;YDLVPSDPSIEEMRKVV 10 10 0.9898 -0.52196 0 3.92742 0 4.11645 6.89166 0 0 9.61727 0 0 0 0 0 9.96881 9.04108 A0A8C0PB92 A0A8C0PB92_CANLF Cationic amino acid transporter C-terminal domain-containing protein SLC7A4 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GIWHSKQNRQEPPEL;SPSPASPSPRVKEYHSF 2 5 0.93912 0.10031 0 0 0 0 0 8.78264 0 0 0 0 0 0 0 0 10.2622 A0A8C0PB93 A0A8C0PB93_CANLF Perilipin Canis lupus familiaris (Dog) (Canis familiaris) EQSYFVRLGSLSERLRQR;VDQKLVEG 2 6.4 1.0035 -1.0561 0 9.72106 0 3.89714 0 0 9.22091 0 0 0 0 0 0 0 0 A0A8C0PBA5 A0A8C0PBA5_CANLF Tetraspanin CD82 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CMKKVQAWLQENV;FLFNLLFFILGA;LLPWCQSPSLQ 3 9.8 0.98935 -0.53144 10.5013 0 0 10.4433 0 0 11.224 11.6885 0 0 0 0 11.2385 0 0 A0A8C0PBA8 A0A8C0PBA8_CANLF C-type lectin domain-containing protein CLEC1B Canis lupus familiaris (Dog) (Canis familiaris) receptor-mediated endocytosis [GO:0006898] cell surface [GO:0009986]; membrane [GO:0016020] DEDGYITLNIKTRK;QREKLILQDRALLNF;QVENKNVSGTLNQL 3 9.8 0.9941 -0.12955 0 0 0 0 0 0 0 0 0 0 0 7.80497 0 5.57159 7.16862 A0A8C0PBB8 A0A8C0PBB8_CANLF Store-operated calcium entry-associated regulatory factor (Transmembrane protein 66) Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of store-operated calcium entry [GO:2001256] endoplasmic reticulum membrane [GO:0005789] LYSPDSSGIRG;PSFPPQRPASRFCIRPRRERP;WNSRAYSPLRGTSGS 3 9 0.99205 -0.1852 0 0 0 0 0 0 0 0 0 0 5.59168 7.5601 0 0 0 A0A8C0PBD4 A0A8C0PBD4_CANLF PNPLA domain-containing protein PNPLA8 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] phospholipase activity [GO:0004620] DTEEVHVMLDGLLPPDTYF;EKTTLQKIND;GVAVKEKIIPYLLRLRQIKD;KKRLSLQREKIIARVSI;LSQEKTTLQ 5 9.6 0.98768 -0.48277 0 0 0 0 0 0 0 0 10.6204 0 0 4.47696 9.02417 0 0 A0A8C0PBE3 A0A8C0PBE3_CANLF Amyloid beta protein binding protein 2 APPBP2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasmic vesicle membrane [GO:0030659]; nucleoplasm [GO:0005654] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DEAYKWCIEAM;ETFKLAQTYMEKLSKHG;GSEFCELE;LASLYNYDMNQYEN;YYKLYQQGRLCQLGSEFCEL 5 10.8 0.99277 -0.049903 0 9.88958 0 0 0 0 0 0 11.3094 0 0 2.60684 0 0 0 A0A8C0PBE5 A0A8C0PBE5_CANLF Coiled-coil domain containing 85A CCDC85A Canis lupus familiaris (Dog) (Canis familiaris) adherens junction [GO:0005912] EEENRMLPQAT;GGGGGGSG;KAIVREMCNVSLMCFI;MSKAAGGA;PSQQPEPV;TSPEHLKQ 6 10.4 1.0038 -2.0405 0 0 0 0 5.63142 0 0 0 0 0 0 8.50795 0 0 8.38534 A0A8C0PBE9 A0A8C0PBE9_CANLF Zonadhesin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMPSLLCQP;EDEDKECPKNTTNPSSCNSGF;ELMMPDEELAQ;IIPTEKTSVPTERP;LAHCGCTNNGV;LCEPLSCRAGEICTLG;LHMDSNTFHRGGV;NLTRGCFRESPCL;PSTTAPSTSMTT;STDNSILTQCDFEDDA;TKKKHPSLLWK;VGPTVLVMPS 12 5.6 1.0032 -2.135 0 0 0 0 9.27055 2.67927 13.5996 8.93292 10.5577 0 0 9.7931 0 0 0 A0A8C0PBG6 A0A8C0PBG6_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; intracellular non-membrane-bounded organelle [GO:0043232] calcium ion binding [GO:0005509] AADLQRFKRDVTE;DDLLFEKLLTPEG;DLLFEKLLTPE;EAYDLFQFFQDLDDEESW;EIDSYDDRFQ;IKARQESLV;KEASLKTNGNST;LEHWLREAEQQAAAE;LEKAWEQRKRMLDQ;QEKEPIVD;QERGALLLRVLK;QIKALNVP;QVSKPRASRELNTRWDSLQ 13 6.6 0.95153 0.053265 0 0 0 0 8.04357 0 0 0 0 0 0 0 0 0 0 A0A8C0PBG7 A0A8C0PBG7_CANLF "gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" BBOX1 Canis lupus familiaris (Dog) (Canis familiaris) carnitine biosynthetic process [GO:0045329] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] FEDVLKNDEHAY;PSLPFLPSFLPFLP;VLKLGKRIGFLY 3 5.9 0.9357 0.090327 0 0 7.39172 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PBH2 A0A8C0PBH2_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" nucleus [GO:0005634] mRNA binding [GO:0003729]; SH3 domain binding [GO:0017124] ETYGDYDYDDGY;GVGVPRGT;YGDYDYDDGYGTAYDEQSYDSY 3 9.6 1.0028 -1.0073 8.11915 0 0 0 3.73314 0 0 0 0 0 0 0 0 9.66968 0 A0A8C0PBJ9 A0A8C0PBJ9_CANLF L-gulonolactone oxidase (LGO) (EC 1.1.3.8) Canis lupus familiaris (Dog) (Canis familiaris) L-ascorbic acid biosynthetic process [GO:0019853] endoplasmic reticulum membrane [GO:0005789] "D-arabinono-1,4-lactone oxidase activity [GO:0003885]; FAD binding [GO:0071949]" LEEVLVSCHLKKSEYFRFLWF;PQFHLQEISFPS;RDSCYMNIIMYRPYGKDVPRLD 3 12.6 0.99242 -0.16609 0 0 0 0 0 11.0577 0 0 0 0 0 0 0 0 11.0138 A0A8C0PBM7 A0A8C0PBM7_CANLF Clusterin CLU Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of apoptotic process [GO:0042981] chromaffin granule [GO:0042583]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] misfolded protein binding [GO:0051787] ELFQDRFFTREPQD;FQRRPFFNPKFRIA;FTREPQDTYHYSPFSL;HDMFQPFFD;NFHDMFQPFFD;RPFFNPKFRIA;RQKHRSQKKKRLI;SSVWVVFFF;TYHYSPFSL 9 13.1 0 2.5129 9.99817 11.1286 0 10.946 12.1251 12.0747 12.432 12.6025 12.7115 0 7.10129 8.36798 12.5235 12.516 12.259 A0A8C0PBN3 A0A8C0PBN3_CANLF Myelin regulatory factor MYRF Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKNSPSLSLHGRTRRGA;GIGHSKHPKSSEPLASPA;HFQVTVYIGMLGE;LVHYRYKPEF;SGPPIKAEPKAPYAPG;VLCVWGVFLSCTPRATSRCP;YPVLQRDLYMKAEP 7 9 0.94538 0.050322 0 0 0 0 0 0 6.90497 0 0 0 0 0 0 0 0 A0A8C0PBR8 A0A8C0PBR8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LQDRDPAGAPPP 1 1.2 0.98515 -0.24608 0 0 10.2328 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PBS2 A0A8C0PBS2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) APPVLTQTPS;APPVLTQTPSA;APPVLTQTPSAS;APPVLTQTPSASA;APPVLTQTPSASAS;APPVLTQTPSASASL;APPVLTQTPSASASLE;APPVLTQTPSASASLEA;SEDEADYYCFTPAS 9 19.9 0 66.432 12.6947 11.7879 12.1597 10.8065 10.873 11.038 12.0439 10.99 11.9231 11.9812 11.6695 11.9633 11.3325 11.2134 11.0995 A0A8C0PBT8 A0A8C0PBT8_CANLF Hepatoma-derived growth factor-related protein 2 HDGFL2 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; muscle organ development [GO:0007517] cytoplasm [GO:0005737]; nucleus [GO:0005634] AEVEKAEEALAGE;ASGGSSGDELGDEDEP;DLVFAKMKGYPHWPARI;ILQKNTDVVATLKKIRRYKANK;RDEERRRELEARRRR;SESEKTSDQKAPSASDSDS 6 15.8 0.98589 -0.43551 0 0 0 0 0 8.89215 0 0 8.99639 0 0 7.62461 0 4.60419 0 A0A8C0PBU4 A0A8C0PBU4_CANLF Dynamin-1-like protein (EC 3.6.5.5) DNM1L LOC119868890 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; rhythmic process [GO:0048511] clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; peroxisome [GO:0005777]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EKKMTEISGYN;KSKPIPIMPASP;LARTLNRLL;VELVHEEM 4 5.8 0.98098 0.035491 0 0 0 0 0 8.17383 0 0 0 0 0 0 0 0 0 A0A8C0PBU8 A0A8C0PBU8_CANLF Calcium responsive transcription factor CARF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEVPERHNLSFFPTV;DIKNHIHEVQKSLRNG;EKSSDRSLPTV;QAHQYHELET 4 8.7 0.99471 -0.1251 0 0 11.1742 0 0 8.61364 0 0 0 0 9.70482 0 0 0 0 A0A8C0PBW2 A0A8C0PBW2_CANLF AF-9 ANC1 homology domain-containing protein MLLT1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DLQSEESDEDDSSSGEEASG;FLNLEGNPPVNHLRCEKLTFN;LEGNPPVNHLRCEKLTFN;QTSAFLVKSPEL;SNSEDEASFKTESAQS 5 11.7 0.99375 -0.031233 0 0 0 0 0 0 8.42345 7.39197 0 0 0 10.8827 3.88723 0 11.6031 A0A8C0PBY0 A0A8C0PBY0_CANLF AB hydrolase-1 domain-containing protein SERHL2 Canis lupus familiaris (Dog) (Canis familiaris) ATGLMMNRDRRV;KEQFQYMEVPGN;WLDNANSFDRLI 3 12.8 1.003 -0.87243 0 0 11.0724 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PBY2 A0A8C0PBY2_CANLF Sodium/glucose cotransporter 1-like Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FPWPGMSLASL;LGSILVMGFAFQE;QEVGGYQELLYKYPGSKP 3 8.4 0.98732 -0.23025 0 0 0 0 0 0 0 0 10.2825 0 0 0 0 0 0 A0A8C0PBZ1 A0A8C0PBZ1_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] plasma membrane [GO:0005886] FLDNPSGREPCAPSQGSHPEL 1 9.2 0.95114 0.049679 0 0 0 0 0 0 0 0 0 0 0 0 0 6.84235 0 A0A8C0PBZ4 A0A8C0PBZ4_CANLF T-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ARRPRRGAGP;RAPPPRREPRRRRRRRSRRRRRRRQ;SPAGMHFSTVTRDME;VPGRRLRP 4 7.8 0.97929 0.035538 0 0 0 0 0 0 0 0 4.56748 0 0 0 0 0 0 A0A8C0PC02 A0A8C0PC02_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509] DQLQKYSEYSSKKI;EPWMQPPCT;PCTVSFANLRAEGE 3 4.3 1.0027 -0.89684 0 9.47007 0 0 0 0 0 0 0 12.0732 0 0 0 0 9.94089 A0A8C0PC17 A0A8C0PC17_CANLF Laminin subunit alpha 3 LAMA3 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] AEECDDCDSC;AGCEGCNC;CNCNSNGHLSSCHPLTGDCIN;EECDDCDSC;EPKDDSPAEECDDCDSCV;EPRPLALRQ;ETLKVMTVRKGLIDTNITVIR;GICINCQHNTAGE;GPSGGCHC;IFDFSTYYLGGIPISI;KDDSPAEECDDCDSCVMT;LANSVLLGPEF;LLLLLLLL;LLLLLLLLP;LLLLLLLP;LVMEAEKHAQ;PSRPVLLLLLLLLPP;PTQVFVDGGRLWPG;RRRKEESDRNYFEGTGYARVPTQ;SLERQVKEMNSLQSDFSKYLTTADS;SPAEECDDCD;SQLQGLSASTGTLE;VGFYSFPICQACQCSVLG;VIGDNSGL;VLLLLLLLL 25 7.7 0.99692 -5.9473 4.04334 9.98214 8.45306 0 7.71987 9.82056 10.2091 11.1823 12.8961 9.65542 6.89567 10.0481 0 6.83517 5.43526 A0A8C0PC19 A0A8C0PC19_CANLF Exosome complex component N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] cytoplasm [GO:0005737]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730] EFRKVARVQPEFL;GTIRFDLELSLNIP 2 15.5 0.9864 -0.38999 0 0 0 0 0 0 0 9.40244 0 0 0 0 0 12.0531 0 A0A8C0PC26 A0A8C0PC26_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] GQDLVSQTEKKLLKRPSK;LNEKQILEKVN;LNEKQILEKVNSQFVVN 3 5.9 0.97188 0.048313 0 0 0 0 0 0 0 0 8.8966 0 0 0 0 0 0 A0A8C0PC27 A0A8C0PC27_CANLF ADAM metallopeptidase domain 15 ADAM15 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CGFPDDCTDPCCDY;DCGFPDDCTDPCCDY;DCGFPDDCTDPCCDYFTCQ;DLVEISQDPGLTLDNFL;DPCCDYFT;EPGEQCDCGFPDDCTDPCCD;EQCDCGFPDDCTDPCC;EQCDCGFPDDCTDPCCD;FPDDCTDPCCDYFTCQ;GEQCDCGFPDDCTDPCC;GEQCDCGFPDDCTDPCCD;GLCCQNCQLRP;GVCDSKGHCHCEEGW;LPLSLLLVVVLVLLGA;MFVEPGEQCDCGFPDDCTDPCC;PGEQCDCGFPDDCTDPCC;PGEQCDCGFPDDCTDPCCD;QCDCGFPDDCTDPCCD;QPQGPAKPPP;RVQGHASS;VEPGEQCDCGFPDDCTDPCCD 21 12.5 1.0019 -1.4193 0 7.50716 7.29581 4.48136 7.14282 9.58748 0 10.3676 7.16932 0 6.51633 11.5711 7.62103 0 0 A0A8C0PC39 A0A8C0PC39_CANLF TOG domain-containing protein CLASP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904]; regulation of microtubule polymerization or depolymerization [GO:0031110] centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776] microtubule binding [GO:0008017] GPPVTPSSEKRSKI;GVVAVRLIIRHTHIPRLIPVITS;LKKMGADLLGSV;QQFNILMRFIVD;SALSTAESVG;SLRGVTEAIE;SSVLGNKFDHGAEAIMPTIFNL;WEQRVNALKKI 8 7.4 1.003 -1.659 11.2149 7.54404 0 0 0 0 10.3821 0 0 0 0 4.70741 0 0 0 A0A8C0PC70 A0A8C0PC70_CANLF "phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" LLLLLLLP;LPALPAAQPPPPLP;NLDGKLHQH;PLLPPRPRLPLLLLPR;PPPPRPLPLLPPRPRLPLL;PRPLPLLPPRPRLPLLLLPRLL;RPRLPLLLLPRPLPLLPA;VGPSRRRRPHQQ 8 11.7 0.99383 -0.12002 0 8.46087 0 0 0 8.08401 0 0 6.41501 8.13145 0 0 0 0 0 A0A8C0PC83 A0A8C0PC83_CANLF Collagen type VI alpha 1 chain COL6A1 Canis lupus familiaris (Dog) (Canis familiaris) GAAPEHHRHGPHVP;PPGPEGSRGAPGP 2 4.2 0.98719 -0.38134 0 10.5526 0 0 0 0 0 0 9.68357 0 0 0 0 0 0 A0A8C0PC85 A0A8C0PC85_CANLF Ribosomal protein L15 UBE2E1 Canis lupus familiaris (Dog) (Canis familiaris) AGTPGAPVSSPRPPEV;SYIGFVCVVVAANA 2 7.2 0.99124 -0.13462 10.5367 0 0 0 0 7.29838 0 0 0 0 0 0 0 8.037 0 A0A8C0PC88 A0A8C0PC88_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] PSEVLIASLVPSLGTKLP;PSLSQEPSLRTRL 2 18.6 0.98963 -0.52919 0 0 0 0 0 0 0 9.13414 0 0 0 0 0 0 0 A0A8C0PCA3 A0A8C0PCA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVGVGGGGLPFH;VGKGRKIGMMVILLGAFQLLF 2 36.3 0.98713 -0.2284 0 0 0 0 0 0 0 3.64916 0 0 0 0 0 0 0 A0A8C0PCA5 A0A8C0PCA5_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] mRNA binding [GO:0003729] GAASGRGARGRGAASAQ;GAPSGRGA;GGGAASGR;GVGNPGAG;LALRILHRKVHVTP;VGEQRQLGE;VGMPGVGP 7 5.3 0.99658 -4.8975 5.10978 9.70193 0 0 0 0 0 11.01 0 10.3012 7.31994 0 0 10.0097 0 A0A8C0PCB7 A0A8C0PCB7_CANLF NADPH oxidase organizer 1 NOXO1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] PAGPEKHTLPL;SVPAGARVSV;SWAEFKELHKTL;TGFFEPQPVDL;VLETSDRGWWL 5 11.6 0.99442 -0.56251 0 0 11.4757 0 0 0 0 0 0 0 0 7.02879 0 11.1039 0 A0A8C0PCG5 A0A8C0PCG5_CANLF Letm1 RBD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ribosome binding [GO:0043022] ITEEKCRTWLGEWLQISCSLK 1 8.9 0.95096 0.049623 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.61058 A0A8C0PCG6 A0A8C0PCG6_CANLF SP110 nuclear body protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] QRKGDSTKKSNLTT 1 2.8 0.93379 0.060855 0 0 0 7.00113 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PCI1 A0A8C0PCI1_CANLF Lipase LIPN Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] "hydrolase activity, acting on ester bonds [GO:0016788]" AYDWGSEAENMHHYNQS;LRYFDLLPDWNHF;PEVWMNISEIITYNG;TQDGYILSINRIP 4 14.6 0.94354 0.059882 0 0 0 0 0 8.5265 0 0 0 0 0 0 0 0 0 A0A8C0PCI7 A0A8C0PCI7_CANLF Piwi like RNA-mediated gene silencing 3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] RNA binding [GO:0003723] GVKLTFIVVKKR;KQEATEFFDHKLVIWPGYVTSILEY;LLLPKTELVSLLKNQVVK;PIMLVPEL;PQQVTYKYNI;VRIFQGRR 6 9.5 0.95271 0.05044 0 0 0 0 0 0 0 0 0 0 2.98687 0 0 0 0 A0A8C0PCI8 A0A8C0PCI8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AVDMLPSGQAV;DAVEVSKTGEAVDVLV;GEAADVVMSGKAADVVP;SGDAIDVVMS;VDVLPIEEAGDVLV;VDVVTSGDVVDV;VLDVLVSGDVDELVS;VLTSGEAL;VTGEAVDMLPSGQA 9 9.3 1.0041 -1.9804 0 0 11.5875 10.5408 0 10.558 6.92005 11.9312 11.9237 0 0 9.88147 4.74561 11.8393 10.0307 A0A8C0PCI9 A0A8C0PCI9_CANLF Euchromatic histone lysine methyltransferase 2 EHMT2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; zinc ion binding [GO:0008270] AGTFLECH;EEEEEEEDDEESGN;EEEEEEEEEDDEESG;EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEEEEEE;GVGSSGPS;HCCPGCGY;QPPVPEKRPPEVQHFRM;SEEEEEEEEEEEEEEEEEEEEEEEE;SLYYDSYSVDERVDSDSKSEVEA;VLCETHRAR;WAPQLPSGLTSP 12 9.2 0.99717 -3.62 0 0 0 6.46565 9.57416 0 7.04614 11.1189 10.3216 0 0 13.1266 0 0.331476 3.52732 A0A8C0PCJ2 A0A8C0PCJ2_CANLF RAN binding protein 2 RANBP2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907]; protein transport [GO:0015031] metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] AELLCKNDVTDGR;DGGSAHGDDDDDGPHF;DLEKDDDAYRTEDSDDIHF;ETSRLETN;FASMTPKK;QTKVTDGESESSDAGSANASD;SFYDQREYIGRSVH;SIPEPTDP;SVQGSVPSPREKS;VDQESTPSFTFQGS;VGQWKERGIGDIKILQ 11 4.7 1.003 -2.4318 0 9.82747 0 8.54125 0 0 6.6605 0 0 0 8.02292 7.34465 0 7.26397 9.21878 A0A8C0PCJ4 A0A8C0PCJ4_CANLF Coagulation factor X (EC 3.4.21.6) (Stuart factor) Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] AAPALAGGPHT;GAAPALAGGPHT;MLEQYDPGDLS;PDEDASGLV;QDCRDGECP 5 8.6 0.13913 0.81229 0 6.78333 9.46097 0 0 0 0 0 0 10.0008 8.75972 9.56482 0 0 0 A0A8C0PCK3 A0A8C0PCK3_CANLF Olfactomedin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GSSCKCAC;HVAHGAAA;LQEETVSQQINSI;LVQTRPLAPPE;NEQIKEDMEEI;RRVCVRATFLRPLPL;VQAAVQLDRHG 8 8.7 0.99932 -3.077 10.6827 0 9.75849 0 0 14.3268 0 10.7001 15.4302 0 5.52344 0 0 0 0 A0A8C0PCK6 A0A8C0PCK6_CANLF R3H domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] FFMEELPGEKDFAH;LLCLDGVFLSSAENDFVHR;LPFRRCLPRAAR;RGSRWGPAPSRRP;RPKLLRLAKVRPQT 5 11.8 0.88263 0.13034 0 9.00938 0 0 0 0 0 0 9.05504 0 0 0 0 0 0 A0A8C0PCK7 A0A8C0PCK7_CANLF BAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229] APPNRPPPP;DLQLHVSAVPEDSNVTASEPQEEV;QRTSAPPNRPPPP;RGAGGGAG;SEVSSSEEEEPLPA;SIQRTSAPPNRPPPPRATPSP 6 10.3 0 1.7447 11.6591 11.9406 11.6436 10.8891 10.9021 10.637 8.45951 11.9688 0 11.7082 11.8818 8.09101 8.02702 11.4972 11.5494 A0A8C0PCL6 A0A8C0PCL6_CANLF Protein transport protein SEC23 Canis lupus familiaris (Dog) (Canis familiaris) COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270] DPWPVTQGKRPL;EAFAMEPAWGS;FQRNQFPPAYTGISEVN;LEATRMVVPLA;TATNGHCI 5 10.1 0.98608 -0.2323 0 0 0 0 0 0 0 0 0 10.75 0 0 0 0 0 A0A8C0PCM5 A0A8C0PCM5_CANLF Sideroflexin 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] monoatomic ion transmembrane transporter activity [GO:0015075] IFGMCDLCASIF 1 3.8 0.95342 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.45319 A0A8C0PCQ2 A0A8C0PCQ2_CANLF ZFP64 zinc finger protein ZFP64 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] CDFCSFDTKRPS;HPEKCPECSYSC;QGQEGARGGSSQHVAKI;TITVSAPEFVFE;YSCSSAAA 5 9 1.0018 -1.2129 0 8.8658 6.77952 0 0 4.88723 0 6.79922 0 0 0 0 0 0 0 A0A8C0PCR4 A0A8C0PCR4_CANLF Cell cycle checkpoint control protein RAD9B Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281] checkpoint clamp complex [GO:0030896] VIQFFCRHGIRRT 1 3.5 0.98824 -0.26104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4324 A0A8C0PCT4 A0A8C0PCT4_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] monoatomic ion channel activity [GO:0005216]; voltage-gated channel activity [GO:0022832] CREFLPQQVREGPG;MVVNNWQVFLDAYRRYSGPWSKL;QWILSFTIFLILF;SAWPLQGGRVRQ 4 6.9 0.98651 -0.39447 0 0 0 0 8.75037 0 0 0 10.5304 0 0 0 0 7.96168 0 A0A8C0PCU7 A0A8C0PCU7_CANLF Eyes absent homolog (EC 3.1.3.48) EYA2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] EEEQGAKKVVLPSPGRAA;EPVSWVSWA;LAPRALPICNRRS;NAAGFGSV;PCPRALPS;RYRRVKEMYNTYRNNVG;STSTYVLQEASHSVP;VLVTTTQL;WMRKLAFRYRRVKEMYNTYRNNVG;YVPASSICPSPL 10 19.6 0.99845 -3.0077 10.5402 0 10.3867 0 0 0 0 0 10.1742 7.57001 9.35548 0 10.377 8.0648 10.3505 A0A8C0PCW8 A0A8C0PCW8_CANLF Sushi domain-containing protein CFH Canis lupus familiaris (Dog) (Canis familiaris) CPTYYHMDGPNFV;HGSLDERYRSYFPVA;IVCKDGRWQSVPRCI;MCIEVESTCGDIPELN;SEKDEITCQMGK;SIVCGDDG;TEDGWFPPPECV;VGRSFYYHCDED 8 8.4 1.0033 -1.6402 9.70982 0 11.1735 8.42387 8.49697 9.4949 0 0 0 0 0 0 0 0 7.21306 A0A8C0PCX9 A0A8C0PCX9_CANLF Calcium/calmodulin-dependent protein kinase type II subunit delta (EC 2.7.11.17) CAMK2D Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] SAAKSLLKKPDGVKKRKSSS 1 3.9 0.96445 0.048658 0 0 0 0 0 0 0 0 0 5.76214 0 0 0 0 0 A0A8C0PCY1 A0A8C0PCY1_CANLF GRAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PGSVFLSSEAENGV;SKSSFEGASL;SPGSVFLSSEAENGV 3 5.1 0.99143 -0.18321 0 0 0 0 0 0 0 0 10.5531 15.0175 0 10.8546 0 10.4783 0 A0A8C0PCZ3 A0A8C0PCZ3_CANLF C2H2-type domain-containing protein REST Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron differentiation [GO:0045665]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]" ALMEPSPPKGPAQL;CQYEAESEEQFVH;LRNHFPRKVYTCGKCNYFSDRKNNY 3 5.6 0.9441 0.061061 9.58244 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PCZ5 A0A8C0PCZ5_CANLF Calbindin Canis lupus familiaris (Dog) (Canis familiaris) regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509] cytosol [GO:0005829]; dendritic spine [GO:0043197]; nucleus [GO:0005634]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509]; vitamin D binding [GO:0005499] RGQLPAAALPALPALPLA 1 5 0.97241 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 4.69677 0 A0A8C0PCZ9 A0A8C0PCZ9_CANLF Adhesion G protein-coupled receptor L3 ADGRL3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930] DIVRENTDNI;EGTWDTAYDKR;GCLDNIKS;MYINESTVIMAYLFT;NLLYVWNNYHVVKY;SFWSYSKRTMTG;YFYLVGYGMPALIV 7 5.6 1.004 -1.0897 0 10.5348 0 0 0 0 9.75531 0 0 11.7954 10.9343 0 0 0 0 A0A8C0PD03 A0A8C0PD03_CANLF Sorting nexin-30 SNX30 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091] EELTDDMTEDFL;LEELTDDMTEDF;LEGVSACIGN 3 5.8 0.99624 -0.10087 0 14.9968 0 14.0308 0 0 0 0 0 9.93142 0 10.6992 0 0 14.9241 A0A8C0PD06 A0A8C0PD06_CANLF Ankyrin repeat domain 28 ANKRD28 Canis lupus familiaris (Dog) (Canis familiaris) DLTLQDNSKNTALH;GGGGGGGG;GGGGGRPG;GVANGRSA;GVANGRSAYSGLSPARP;LDERGCTPLH;PPTAPRARAPDY;SDRAGRTALHHAAF 8 5.5 1.0027 -2.1709 0 0 16.4961 11.1935 0 0 9.89488 0 0 0 0 0 0 0 0 A0A8C0PD12 A0A8C0PD12_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PLASLIKKKKEK;PSICCLQETHFRQ 5 4.3 0.9556 0.05044 0 0 0 0 0 0 4.5404 0 0 0 0 0 0 0 0 A0A8C0PD29 A0A8C0PD29_CANLF Interleukin family protein IL20 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125] DEVIDIRILRK;SVSHYFSFEFL 2 10.9 0.98973 -0.26608 0 0 0 0 0 0 0 0 0 0 0 0 0 4.90116 0 A0A8C0PD31 A0A8C0PD31_CANLF DRBM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EELKKLPPLPTVERVKPRIKK;ELKKLPPLPTV;IKKKTKSIVRLQ;IVRLQSNTDCGQGMNPISR;KPRIKKKTKSIVR;LPSENAGRPI;RVKPRIKK;SNKEDEFRMPY;TSNKEDEFRMPY;VKPRIKKKTKSI;YNYNMRGGAYP 11 13.2 1.0032 -2.1396 0 6.34635 0 0 4.68975 0 13.9102 0 14.5548 9.52215 13.0176 9.5484 13.0955 13.134 12.823 A0A8C0PD34 A0A8C0PD34_CANLF PDZ domain containing 8 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739] lipid binding [GO:0008289]; metal ion binding [GO:0046872] GGGGGGGA;GGGGGGGG;GVWEEKQRSSIKTVE;HLVEEVSALPK;ITSTLQVL;IVNQLKKIIKRK;IVNQLKKIIKRKH;PDEAARAGDGFRYI;VPSVSHSP 9 6.8 1.001 -0.64415 0 0 0 0 0 0 0 0 9.84227 0 0 0 10.6662 3.23297 0 A0A8C0PD42 A0A8C0PD42_CANLF Neurobeachin like 1 NBEAL1 Canis lupus familiaris (Dog) (Canis familiaris) DEKERKALE;EDPMGTIDK;EEDVTARVNTDEKEEQDQKEKLVL;EQMLKCTNVYERS;ESEYIHPYTTP;ESEYIHPYTTPV;QYETHTFYNNHESMALYWKNCY;RPPCESSLLLTVP;RQTKTDTST;TQKWVNREISNF;TSERGPWAERKQNP;VISHNIRHMDIVT;YMKQYETHTFYN 13 5.9 1.0036 -1.6842 11.0954 12.4569 12.793 6.50662 12.3285 13.2761 11.3754 13.4389 13.9841 6.91241 12.3959 8.68583 0 7.5051 7.40276 A0A8C0PD54 A0A8C0PD54_CANLF M-phase phosphoprotein 8 MPHOSPH8 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin formation [GO:0090309] cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; plasma membrane [GO:0005886] chromatin binding [GO:0003682]; histone reader activity [GO:0140566]; methylated histone binding [GO:0035064] KKAKTGKL;KKKAKTGKLKDK;LRSTDSAGEEKE;VSMTASPVSGAAGNVE 4 4.7 1.003 -1.3284 0 0 0 0 0 0 6.36699 3.10507 6.15413 0 0 10.2888 0 10.6164 0 A0A8C0PD55 A0A8C0PD55_CANLF C2H2-type domain-containing protein ZNF608 Canis lupus familiaris (Dog) (Canis familiaris) EMKSVMDSMKQTGVD;GARVAVSSPMSQHQ;GVDPNTVDTYDSGDD;GVNTCEVGVLTEP;ISGTGRRQE;LHTHHHTHVGMG;WHHYVYQPKYLDQQK 7 6.2 0.99078 -0.51277 0 0 8.48547 0 0 0 9.72098 0 0 5.02622 0 0 0 6.13752 0 A0A8C0PD61 A0A8C0PD61_CANLF Ankyrin repeat and BTB domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) protein heterodimerization activity [GO:0046982] EAARRLAGLLRRALIRVAREAQRLS;GGGGGGGG;GGGGGGPG;PHAASTPSCPHRSLFTL;PSIHPDSRH;RLAGLLRRALIRVAREA;SHPSARQSRCSVSS;VINNDAELWGVLQPYEH;VLPEDPEVA;VPGHEALPRWLCSPP 10 10 0.8574 0.16788 0 0 4.35064 0 0 0 9.8781 0 7.3427 0 0 0 0 0 0 A0A8C0PD64 A0A8C0PD64_CANLF Cyclin N-terminal domain-containing protein CCNT2 Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of transcription by RNA polymerase II [GO:0006357]" cyclin/CDK positive transcription elongation factor complex [GO:0008024] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575] DELTHEFL;IVYMHRFYMHHSFTKFNRNAYLQQ;LSSHQEWP;QIYSQKQETSLSGSQYNINFQQ;TLELLDELTHEFLQILE 5 11.4 0.9721 0.041303 0 8.78454 0 0 0 0 0 11.1191 11.3737 0 0 0 0 0 0 A0A8C0PD70 A0A8C0PD70_CANLF BTB domain-containing protein RCBTB2 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGGGGGGPGGGV;GGGGGGPG;SLCSEEEL;SLSYGESGKPVQATLSSL;SPRGGGGGG;TDDVFACFATPAV 7 10.1 1.0028 -0.98433 7.4839 0 0 3.57531 0 0 0 0 0 8.45878 0 0 0 0 0 A0A8C0PD78 A0A8C0PD78_CANLF Double zinc ribbon and ankyrin repeat-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] metal ion binding [GO:0046872] DLAAGELGPF;FKTKKFQEK;LDNSLDLAAGELGPFAESPRVP 3 6.9 0.95056 0.059228 0 0 0 0 0 0 0 0 7.69384 0 0 0 0 0 0 A0A8C0PDA4 A0A8C0PDA4_CANLF LHFPL tetraspan subfamily member 1 LHFPL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SYFLPYWLFGSQLGK;VTAVASSTSYFL;YSTMYLSAWLG 3 13.4 0.98715 -0.32677 0 0 9.30957 0 10.0757 0 0 0 0 0 0 0 0 0 0 A0A8C0PDB5 A0A8C0PDB5_CANLF Pleckstrin PLEK Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein kinase C signaling [GO:0070528]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904] cytoplasm [GO:0005737]; ruffle membrane [GO:0032587] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]" DHFFQAAFLEERDSWV;EDGIEFYKK;HPFLDNPDAFYYFPD;HPFLDNPDAFYYFPDSGFFCEE;MDTGAGLGAENEPQKL;VIDWLVSN 6 19.8 1.0031 -0.86343 0 0 9.16729 6.77795 0 0 9.75263 12.6853 0 0 9.50831 0 0 0 0 A0A8C0PDC4 A0A8C0PDC4_CANLF Coiled-coil domain containing 158 CCDC158 Canis lupus familiaris (Dog) (Canis familiaris) ALDKASLQFAECQDIIQ;DKVIEILRQQIENMTQLVGQHG;LGVSYVAVEPVTLHTGDL;LQELRSVINEEPAV;QEKRIQKVKDQEKM;QSQLEIIQEQARNQ 6 9.2 0.99249 -0.17738 0 9.74158 0 0 0 0 10.1468 0 0 0 0 0 0 0 0 A0A8C0PDD1 A0A8C0PDD1_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AEPPAPAFRRA;DGLPEGLHLGE;EVVQEHAAESI;IQIEGYMPLDCMFCNQ;TDNDDSCSEKEE;VEAEYLSPLDK;VSPHEPVH 7 7.1 1.0043 -1.089 0 4.13044 0 0 0 0 8.34908 6.70086 0 0 0 0 0 9.1397 9.23072 A0A8C0PDD8 A0A8C0PDD8_CANLF Olfactory receptor family 7 subfamily A member 17 OR7A17 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LQSLMVLWLSFCSE;PGSHFCYM 2 6.8 1.0022 -1.3012 0 0 10.9347 0 0 0 0 0 0 0 6.91241 0 0 0 0 A0A8C0PDE4 A0A8C0PDE4_CANLF Exostosin like glycosyltransferase 3 EXTL3 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] DSHFHERHKCINFFV;FYRSWNSAPGPFHLFP;LAMRRQGRFLWETYFS;PAAPIREEAAAE;VIRGCRLHNCFDYSRC;VLMNSLERLNGLPYLNK 6 10.6 0.65182 0.32246 0 5.95949 7.81038 0 0 0 10.5568 0 9.2884 0 8.04089 0 9.35359 0 0 A0A8C0PDG1 A0A8C0PDG1_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] membrane [GO:0016020]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] FDLFPSPTPFFSPFFFFLFFFFFFF;SETVLSPTELQNLD;TPFFSPFFFF 3 6.1 0.9847 -0.23877 0 0 0 0 0 0 0 0 8.6749 0 0 0 0 9.18688 0 A0A8C0PDG2 A0A8C0PDG2_CANLF Protein LTV1 homolog LTV1 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit biogenesis [GO:0042274] DNLLEDDFILQANK;IPIVKKAPQSKPQSM;KSEAEDDSEWEDMDDEKERGS;NHLFWEEETKSRFTEYSITSSVMRR;RFEKFYEQY;TQKVNDEER 6 18.6 1.0027 -1.1961 0 11.6339 0 0 4.16768 8.58988 0 0 9.98042 0 0 0 0 0 0 A0A8C0PDG8 A0A8C0PDG8_CANLF Rubicon Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) APGEARGRAGRGPGDPGGP;DDFVVVELGE;DLHLFSLEDLVRVKKRLLVPL;EDLVRVKKRLLVPLLKDIL;FCDCCHTYADSC;IREAEDWEPPRFQIIFDVHPPLKR;LRYCDYLGKYFCDCCHTYADSCIPA;LVRVKKRLLVPL;LVRVKKRLLVPLL;LVRVKKRLLVPLLKDIL;LVRVKKRLLVPLLKDILKASL;PAQEGAVQ;PRHLTDDLHLFSLE;TCGCSCSSS;YVADMIIAAME 15 23.9 0.98572 -0.2324 0 0 0 0 0 0 0 10.6608 0 0 0 0 0 0 0 A0A8C0PDI2 A0A8C0PDI2_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] DLHIQRVLRVNRT;FPGFEGPGRCGSRAPSLG;GRFREQKSPESIWTPVPE;GRSGGGEA;GVVSLGGRPVVL;LAVFSTPSNSIPGS;PAPLLLLLL;PTGPSDPA;SVFLEEFETYRPDRCGRSG 9 11.9 0.99918 -3.1262 0 0 11.0486 11.4189 10.5921 10.009 0 9.48208 0 10.7074 10.6003 10.7622 10.9968 10.3886 0 A0A8C0PDJ2 A0A8C0PDJ2_CANLF PID domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; positive regulation of neurogenesis [GO:0050769] ACCHGGGGG;CCHGGGGG 2 1.3 1.003 -1.9086 5.00509 0 0 0 0 4.33428 0 0 0 6.53034 6.03844 0 0 0 0 A0A8C0PDL3 A0A8C0PDL3_CANLF SEA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCFLVTVCRRKKEGEYEVQQDS;HEEDMVPGSWRFNATQR 2 4 0.9365 0.092926 0 0 0 0 0 6.90159 0 0 0 0 4.10467 0 0 0 0 A0A8C0PDP4 A0A8C0PDP4_CANLF sn-1-specific diacylglycerol lipase (EC 3.1.1.116) DAGLA Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] plasma membrane [GO:0005886] DQEEEEGGGGGGV;LSASTPLYPP;NHPAEQCCCCEQ;SSLQDLYCMV;VGSDDLVLPAIFLFL;VHNHPAEQCCCCEQEEPT 6 6.3 1 -0.6147 11.7508 0 0 6.95675 0 0 11.4859 0 0 0 9.36599 0 0 0 11.2691 A0A8C0PDQ3 A0A8C0PDQ3_CANLF Dedicator of cytokinesis 10 DOCK10 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AEYKPEKLPS;DEWIHTLNR;FSPLYRQESS;GVVQNNRLRKYAFELKMNDLTYFV;IIAVFEKQRDF;LSCSLLHAQ;SKGGGGAG;SSSKGGGG;SVDRDSRFSPLYRQE;TVPEDAEHKAE;VGFFEEEEGKEYIYKEPK;VTPRQSEEPH 12 5.9 0.99947 -2.9187 0 6.29002 0 10.0111 12.2367 4.94312 0 0 0 0 10.8818 8.63278 0 0 10.9476 A0A8C0PDR9 A0A8C0PDR9_CANLF Myosin XIX MYO19 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion migration along actin filament [GO:0034642]; mitocytosis [GO:0160040]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial fission [GO:0090140] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; myosin light chain binding [GO:0032027]; plus-end directed microfilament motor activity [GO:0060002] DICPEPSP;EYTVEGLEWSF;INYANEKLQQHFVAHYLKAQQ;LVYARLFDWLVS;VGEQTYRNV 5 6.2 1.0032 -1.5782 7.42366 0 0 9.58018 0 0 0 9.59826 0 0 0 0 0 0 7.18953 A0A8C0PDT2 A0A8C0PDT2_CANLF Olfactory receptor LOC119868942 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DIKRALKRIVRVPVIPGPIVPGL;KRIVRVPVI;QSSHASAIASV;TQMYFFTLFAVLDV 4 14.9 0.98789 -0.48828 0 6.43706 0 8.48071 0 5.53615 0 0 0 0 0 0 0 0 0 A0A8C0PDV8 A0A8C0PDV8_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] EATNKQSRS 1 1.5 0.99671 -0.090854 0 0 11.4523 0 0 0 11.7705 0 0 0 0 12.1181 0 0 0 A0A8C0PDW1 A0A8C0PDW1_CANLF NEDD4 binding protein 2 like 1 Canis lupus familiaris (Dog) (Canis familiaris) AYEFNPDFLEEAHEWNQ 1 9.9 0.98444 0.046227 0 0 0 0 0 0 0 0 0 0 10.3306 0 0 0 0 A0A8C0PDW2 A0A8C0PDW2_CANLF SH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RRARLPVEDERPAAEYEQPWEWKKE;SPDAPRPAAPQSPA 2 5.5 0.98727 -0.35497 0 0 0 0 12.3664 0 0 0 0 0 0 0 9.94556 0 0 A0A8C0PDX8 A0A8C0PDX8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AKCVSTPAAASLSSPWVFAYFRPD 1 15 0.9713 0.041303 7.0321 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PDZ5 A0A8C0PDZ5_CANLF Annexin Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of coagulation [GO:0050819] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] GAGTDDHTLIR;RVFDKYMTISGFQ;TLLTSRSNAQRQ 3 11.4 0.99378 -0.17598 0 0 0 0 0 0 0 0 10.1165 0 0 0 0 10.8609 0 A0A8C0PE15 A0A8C0PE15_CANLF Maestro heat like repeat family member 7 Canis lupus familiaris (Dog) (Canis familiaris) GVHKPWEILASFP;LLLEPNRRIEVQ;QEVGNTNHLTAFVFMTE;VLRWSRLR;VLVFPLKHQVLNLTVLLVLHL 5 8.2 0.99263 -0.14144 0 0 9.18455 5.09753 9.19852 0 7.95338 0 0 0 0 0 0 0 10.0164 A0A8C0PE50 A0A8C0PE50_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LTSLYLRKMP;VLSISLFGNPLIC 2 4.6 0.99373 -0.19117 0 0 0 0 0 5.50637 0 14.2935 0 0 0 0 0 0 0 A0A8C0PE58 A0A8C0PE58_CANLF Estrogen related receptor gamma ESRRG Canis lupus familiaris (Dog) (Canis familiaris) nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518] nucleus [GO:0005634] estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; zinc ion binding [GO:0008270] EALQDYEAGQHME 1 3.3 0.94079 0.059724 0 0 0 0 0 0 0 6.45505 0 0 0 0 0 0 0 A0A8C0PE91 A0A8C0PE91_CANLF Septin-10 SEPTIN10 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] KAELQKFKIKLMSELVS;KFKIKLMSELVSNGVQIYQFPTD;LSSLKIMKTTPSKTKRAIVG;VNRSIQQGFCFNILCVGETGIGK 4 16.2 0.97228 0.048206 0 0 0 0 0 0 0 0 0 9.09239 0 0 0 0 0 A0A8C0PEA9 A0A8C0PEA9_CANLF "SEC24 homolog B, COPII coat complex component" SEC24B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] EEEEDEEAGVDSSSTTSSA;IWIGKSCDNNFIEDVLG;KPFGYGYPTLQP;NFIEDVLGYPN;TQERNILPM 5 5 1.0037 -0.82357 0 0 0 0 0 4.69137 0 6.77676 0 5.88653 0 0 11.5733 0 0 A0A8C0PED1 A0A8C0PED1_CANLF RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) NAT10 Canis lupus familiaris (Dog) (Canis familiaris) rRNA acetylation involved in maturation of SSU-rRNA [GO:1904812]; tRNA acetylation [GO:0051391] nucleolus [GO:0005730] ATP binding [GO:0005524]; N-acetyltransferase activity [GO:0008080] EACELYYVNRDTLFCYH;ELKESLQDTQPVGV;GVAERQRSLFVVVGD;LVDCCKTLDQAKAV;PSGQLMGLFNRIIRKVVKL;QSAQSQISTTAENKATTTARLA;QVVILHHML;RFILSLASCKKCL;TQPALSREELDALF 9 14.5 0.98638 -0.32302 7.92997 0 9.90289 10.0326 0 0 10.1812 11.1885 10.0351 9.75129 9.30533 4.13931 0 0 0 A0A8C0PED2 A0A8C0PED2_CANLF RB transcriptional corepressor 1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] CFGGSGGA;ESLAWLSDSPL;GVRSLDTAPPP;KDLPHAVQ;QPSENLISYFNNCTVNP 5 4.5 0.99002 -0.26592 0 0 0 11.0231 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PED7 A0A8C0PED7_CANLF Protein NDRG3 (N-myc downstream-regulated gene 3 protein) NDRG3 Canis lupus familiaris (Dog) (Canis familiaris) DKEHDIETTHG 1 3 0.98428 -0.25512 0 0 0 0 0 0 12.1798 0 0 0 0 0 0 0 0 A0A8C0PEE0 A0A8C0PEE0_CANLF Kelch-like protein 15 KLHL15 Canis lupus familiaris (Dog) (Canis familiaris) nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634] ESQGCPSTE;LMTPSSVFEKVKTSEFYRYSRQLRY;NSKILLLKKPRVWWELEG 3 8.9 1.0036 -1.0552 6.88448 0 0 0 5.35082 0 0 0 0 0 0 0 0 0 0 A0A8C0PEF1 A0A8C0PEF1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;ATRSRRRELIKIRAELNEIET 2 4.9 0.97443 0.047166 0 0 0 0 0 0 0 0 0 0 0 6.02956 0 0 0 A0A8C0PEF3 A0A8C0PEF3_CANLF "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124)" DECR1 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] ELANLAAFLCS;NKVHAIQCD;PLPSPPPPLLDPTRSGP 3 6 0.99254 -0.18038 0 8.87274 0 0 9.16794 0 0 0 0 0 8.41193 0 0 0 0 A0A8C0PEG4 A0A8C0PEG4_CANLF Protein kinase domain-containing protein CDK10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] GVPISSLREITLLLRLRHPNIVELK;GVPLCGTCLWECPLGW;PWLSEAGLRLLNF;YFKEKPLRE 4 15.7 1.0023 -0.65988 0 0 6.79533 0 8.95797 0 0 0 0 0 0 0 0 7.0935 0 A0A8C0PEI0 A0A8C0PEI0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] AKILNKILANRIQQHIKKVIH;MNEKGEITTNT;PSICCLQETHFRQ 3 6.6 0.97382 0.047166 0 0 0 0 0 0 0 0 7.87486 0 0 0 0 0 0 A0A8C0PEI7 A0A8C0PEI7_CANLF Leukemia NUP98 fusion partner 1 Canis lupus familiaris (Dog) (Canis familiaris) KDDDDDDDDDD;KDDDDDDDDDDD 2 6.6 0.94058 0.085931 0 0 3.36807 0 0 0 0 0 0 0 0 0 0 0 4.10518 A0A8C0PEI8 A0A8C0PEI8_CANLF Pyridoxal phosphate binding protein Canis lupus familiaris (Dog) (Canis familiaris) pyridoxal phosphate binding [GO:0030170] HLVVLILKIT;KRFSRKVKVYSIGHLVVLILKI 2 16.1 0.99532 -0.56476 0 0 0 0 4.12433 0 0 0 0 0 0 0 0 4.48123 0 A0A8C0PEK0 A0A8C0PEK0_CANLF Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (Ecto-ATP diphosphohydrolase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) ENTPD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] KVIDTMEKFCSQPWEEIQSSNVG;NYHFDFQGARIITGQEE;SRYAHKLSEIDIYLTECMIRAS 3 13.4 0.97892 0.04627 0 0 0 0 0 0 0 8.864 0 0 0 0 0 0 0 A0A8C0PEK5 A0A8C0PEK5_CANLF DNA-directed RNA polymerase I subunit RPA12 (DNA-directed RNA polymerase I subunit H) Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EGMAYHTRQMRSADEGQTVFY;LDGTGAAHRRTLCAMD 2 17.8 0.95582 0.049233 0 0 0 0 0 0 0 0 0 0 8.61802 0 0 0 0 A0A8C0PEL2 A0A8C0PEL2_CANLF Sorting nexin SNX5 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; pinocytosis [GO:0006907]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768] dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091] SPYQCHWAD 1 2.2 0.98389 -0.25453 0 0 0 0 0 0 9.10554 0 0 0 0 0 0 0 0 A0A8C0PEL4 A0A8C0PEL4_CANLF Vacuolar protein sorting-associated protein 52 homolog Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] Golgi apparatus [GO:0005794] KHLESYLTDCYDAI;SLHGGGPG 2 4.7 0.99021 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8371 A0A8C0PEM5 A0A8C0PEM5_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EGEFPWQVSI;KRVDQLSRNMVCAWKEPG;LEEPDKVQCGHRPAFSNSSSLKFRE;LMMFKGHVLEE;SSLKFRELFEVQ 5 24.8 1.0035 -1.0666 0 0 0 0 0 0 0 9.23957 10.3979 0 0 0 0 0 0 A0A8C0PER9 A0A8C0PER9_CANLF G protein-coupled receptor 162 GPR162 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AIMSEEDGDDDGGCD;AIMSEEDGDDDGGCDDYADGRV;DGDDDGGCDDYADG;EEDGDDDGGCDD;GDDDGGCDD;GDDDGGCDDY;IMSEEDGDDDG 7 7.2 1.0028 -1.8905 0 0 8.66693 0 8.16962 5.91088 5.07493 5.18408 0 0 0 0 0 0 0 A0A8C0PET0 A0A8C0PET0_CANLF Anion exchange protein SLC4A2 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;GEKTQDLIGVSELIMS;GETPTIEEGEEDEEEASEAEG;HPSDEKDFSFP;PGASPTGETPTI;PGFPEQEDDEL;RSQPEPESLGP;SDPHVTEPLIGGVPETR;SEAEGTRALSQ;SSVQFFLQ;SSVQFFLQE;TAPEKRGWVINPL;VEVAGAVEDDPLRR;VGLSIVIGDLLRQIPLAV;VGLSIVIGDLLRQIPLAVLFGIFLY;VKKVRTLR;YGEEDFEYH 17 15.5 0.98446 -0.24616 0 0 0 0 0 0 0 0 0 0 0 9.83474 0 0 0 A0A8C0PET1 A0A8C0PET1_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EFVVLKKD;FGPGPGYG;GGSGSAWA;QEREQIKALNNKFASFIDKRFLEQ;VDSLDKDLKF 5 10.9 1.0006 -2.7988 0 0 0 0 0 0 0 0 8.08316 0 0 9.22448 0 0 9.64654 A0A8C0PET7 A0A8C0PET7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;INNIDKPLASLI;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.5 0.94268 0.05044 0 0 5.42018 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PEU3 A0A8C0PEU3_CANLF Adhesion G protein-coupled receptor E2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;GVDELLET;GVDELLETPGDLEAL;NECGPPPLVSCGRLADCQ;SLHLQLSICLFLAHLLF;TEIKVLCSI;TICTIYVNESTSG;TVGSYQCRCRRGWEPK;VDELLETPGDLEAL 9 13.5 0.99222 -0.1932 0 0 0 0 8.28716 0 0 0 0 0 7.18418 0 0 0 0 A0A8C0PEV2 A0A8C0PEV2_CANLF Spermatogenesis associated 16 SPATA16 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] Golgi apparatus [GO:0005794] IDKWLQVALKDASSCY 1 2.9 0.95817 0.049233 0 0 0 0 0 9.50383 0 0 0 0 0 0 0 0 0 A0A8C0PEV8 A0A8C0PEV8_CANLF succinate--CoA ligase (ADP-forming) (EC 6.2.1.5) Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] EINPMVEDSDG;SLAPPAPG 2 2.2 1.0042 -1.1044 0 0 0 0 0 0 0 0 10.5911 0 0 0 0 0 0 A0A8C0PEX7 A0A8C0PEX7_CANLF Pecanex-like protein PCNX4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVSDEKWKEAVLQEKPY;RAFRKVWQS;SVERMLTTDILAE;VLLFVFGWMTL;VTSYFIPSTVG;YYQMVPSLTTA 6 6.5 1.0045 -1.0946 0 0 0 10.6099 0 0 0 12.2903 11.1299 0 0 0 0 10.6311 0 A0A8C0PF21 A0A8C0PF21_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] GSGPPGGGA;GVCDECGG;GVSDLSPGARQYVS;HNGHIKLPG;LDCWQKDRNSRPKFDEIV;LPGKRELP;SCCECGCG;SGSCCECG;YFRRESDPP 9 8.2 0.99687 -5.5779 6.91922 11.9851 6.60842 0 6.36073 7.54813 7.4065 5.23775 0 8.30825 6.4738 6.94345 0 7.08937 8.36203 A0A8C0PF22 A0A8C0PF22_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] PLHPEASGAPGA;VFLRAPFSK;VGQVGQVGQAG;VGYIDSSINNVS 4 3.6 0.985 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 9.64695 0 0 A0A8C0PF25 A0A8C0PF25_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AASSYLSLTPDK;ASSYLSLTPDK;EDEDDYYYCGAD;GSPVTQGVETTK;GSPVTQGVETTKPSK;GSPVTQGVETTKPSKQ;GVETTKPSKQSNNKYAASSY;GVTVAWKADGSPVT;ISNIKSEDEDDYYYC;KADGSPVTQGVE;KADGSPVTQGVET;KADGSPVTQGVETTK;KADGSPVTQGVETTKPS;KADGSPVTQGVETTKPSKQ;KADGSPVTQGVETTKPSKQS;KYAASSYLSLTPDK;LTVLGQPKA;NKYAASSY;NKYAASSYL;NKYAASSYLSLTPDK;NNKYAASSY;NNKYAASSYL;PVTQGVETTKPSKQSNNKYAASSY;QSNNKYAASSYLSLTPDK;SEDEDDYYYCGA;SNNKYAASSY;SNNKYAASSYL;SNNKYAASSYLSLTPDK;SPVTQGVETTK;SPVTQGVETTKPS;SPVTQGVETTKPSK;SPVTQGVETTKPSKQ;SPVTQGVETTKPSKQS;SPVTQGVETTKPSKQSN;SPVTQGVETTKPSKQSNNKYAASSY;SSYLSLTPDK;SYLSLTPDK;TTKPSKQSNNKYAASSY;TTKPSKQSNNKYAASSYLSLTPDK;TVLGQPKA;TVLGQPKAS;TVLGQPKASP;TVLGQPKASPS;TVLGQPKASPSVTL;TVLGQPKASPSVTLF;TVLGQPKASPSVTLFPPSSEELG;VETTKPSKQSNNKYAASSY;VETTKPSKQSNNKYAASSYL;YAASSYLSLTPDK;YLSLTPDK 50 34.4 0 110.24 15.1633 15.2534 15.2887 10.9367 10.971 10.764 14.0921 14.5006 14.3209 14.2626 14.4817 14.0895 14.3351 14.2136 14.4326 A0A8C0PF41 A0A8C0PF41_CANLF Carboxypeptidase N subunit 2 Canis lupus familiaris (Dog) (Canis familiaris) EALPEGLFGHMEALESLQLQG;ELLSLSRNLLTTLPT 2 6.9 0.99472 -0.19091 0 0 0 0 0 0 10.5478 0 0 0 0 0 0 10.1 0 A0A8C0PF42 A0A8C0PF42_CANLF von Willebrand factor VWF Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; cell-substrate adhesion [GO:0031589] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] CEGNTSSCGDQPSEGCF;CPCYYDGE;DCTCFCDT;DEYECACNC;DHHTMCYCEDGFM;DIFSDHHTMCYCED;EAGSRSRWRGSGFSPCPGDSQ;GFQLSCKTSECCPTCHCE;LGYKEEKNQGECCG;LHVKEVCQEQCVDGCSCPEG;LSYPEEDCNEVC;MCYCEDGFMHCT;NPSDPEHCQ;PNTVSVHCFLLVI;QDQCSCCSPTQTE;RLARNLVRYVQGLKKKKVIV;RNLHENGY;TQCCDEYECACNCVNSTVSCP;VDELEQRRDEII;VGGVCAGG;VGLSCWEHGLGRW;WNCTDHVCDATCSA 22 8.6 0.99677 -5.1284 5.30111 10.4337 9.82276 9.28552 6.43289 8.83504 11.0589 9.38894 10.3021 7.59932 5.51099 7.92244 0 0 0 A0A8C0PF73 A0A8C0PF73_CANLF Olfactory receptor LOC488311 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVLLAVMAYDR;LAFALAIFIILTPLILI;TIIYMYLQ 3 11.7 1.0034 -1.3812 0 10.0856 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PF97 A0A8C0PF97_CANLF Transmembrane serine protease 2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] GTERSFWTI 1 1.8 1.0044 -0.80421 0 0 0 0 0 0 0 0 0 0 7.97699 0 8.01848 0 0 A0A8C0PF98 A0A8C0PF98_CANLF Triacylglycerol lipase (EC 3.1.1.3) (Pancreatic lipase) Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular region [GO:0005576] metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806] DLITPLFSFDFSAYKE 1 3.7 0.98546 -0.25322 0 0 0 10.1422 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PFA3 A0A8C0PFA3_CANLF Bcl-2 Bcl-2 homology region 1-3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] MDRRPQVCGEHGARLP 1 4 0.95589 0.049233 0 0 0 0 9.303 0 0 0 0 0 0 0 0 0 0 A0A8C0PFA6 A0A8C0PFA6_CANLF Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) Canis lupus familiaris (Dog) (Canis familiaris) "base-excision repair [GO:0006284]; DNA replication, removal of RNA primer [GO:0043137]" mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; DNA binding [GO:0003677]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523] FMCGEKQFSEERIRS 1 4.2 0.99721 -0.087397 0 0 0 0 0 0 0 0 11.6893 0 0 0 0 0 0 A0A8C0PFB7 A0A8C0PFB7_CANLF Alkylglycerone-phosphate synthase (Alkyl-DHAP synthase) (EC 2.5.1.26) AGPS Canis lupus familiaris (Dog) (Canis familiaris) ether lipid biosynthetic process [GO:0008611] peroxisome [GO:0005777] alkylglycerone-phosphate synthase activity [GO:0008609]; FAD binding [GO:0071949] ASGMKKNIYGNIE;FNYRGISDPLTVFEQ;TSAPWDRVVDLCRNVKERITRECKE;VHIKMVTPRGIIEKSSQ;VLSGHLRGRPWE;WGYNDSKFFFNKKG 6 15.8 0.99693 -0.5977 7.61331 0 0 0 0 6.15241 0 11.4686 0 0 0 0 5.89504 0 0 A0A8C0PFB9 A0A8C0PFB9_CANLF ETS transcription factor ERG ERG Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" ERRVIVPADP;HPPALPVTSSSFFAAP;HYLRETPLPHLTS;LPVTSSSFFAAPNP;YDPPRRSAWTSH;YYYDKNIMTKVHG 6 13.1 1.0007 -0.63554 0 7.749 8.43888 0 0 0 0 0 0 0 7.30524 0 7.21267 0 0 A0A8C0PFC2 A0A8C0PFC2_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DELVIPAYGEVGS;DHLQTFAEGQDEDFME;EESGEIMSLPSPIRQSWNFR;ESSIRNKMEGQR;FQEYESQI;KAAEYEDDQEKIKKQ;KRTSLLAKL;LEQLQDEFNFVSE;LKDNIYINIFDEMIEKH;TPMAVHFDYLKESFWKQLL 10 10 1.0034 -1.6232 13.0036 16.7642 0 0 0 0 17.3831 5.23032 0 11.7668 16.0732 15.5542 12.4293 12.4022 17.284 A0A8C0PFC5 A0A8C0PFC5_CANLF Oxysterol binding protein like 6 OSBPL6 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] EQIHVSLPLSQQVAN;RIDLDTEEHIYHLKVKSQDWFDAW 2 7.8 0.98548 -0.2371 0 0 0 0 0 0 0 0 0 0 0 9.64416 0 0 10.076 A0A8C0PFC7 A0A8C0PFC7_CANLF R3H domain and coiled-coil containing 1 like R3HCC1L Canis lupus familiaris (Dog) (Canis familiaris) DLLRVFCSY;KETLSQGHQQSIPDPGMIPSIS;VRTADEACSSTDSLSKYLEMSAD;YAESISSSFTEST 4 8.9 1.0036 -1.1081 0 0 7.90418 0 7.72274 0 11.0625 8.42227 6.73539 0 6.77294 0 10.0821 8.12567 8.09307 A0A8C0PFD1 A0A8C0PFD1_CANLF Doublecortin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; intracellular signal transduction [GO:0035556]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; photoreceptor outer segment [GO:0001750] AHSKSGEGLPCSGIS;DTVVREWLSNIPE;EEFCPCEACMR;FHLLGKDAVLWSRRVGRASALP;GTDSRRRSRLTQHS;LVCAGYESFKP;PGSRYEIWMNPL;PKAPRRIVLVK;QNDGDKSEEIQ;QTGHPRQHHRPLDSP;RWEMSLQTEQRRRR 11 7.9 0.98759 -0.2305 0 0 0 0 0 0 0 0 0 0 0 0 0 9.16138 0 A0A8C0PFD6 A0A8C0PFD6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LLLPLLLR;LPLLLRVAVIGQ;VGGVVVVVVVVVLRRGRLV;VGGVVVVVVVVVLRRGRLVG;VVVVVVVLRRGRLVG 5 13.6 0.98757 -0.49671 0 0 5.43336 0 7.49193 0 0 0 0 0 0 0 0 0 6.05498 A0A8C0PFE8 A0A8C0PFE8_CANLF Leucine rich colipase like 1 Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576] enzyme activator activity [GO:0008047] NSHTCSEHSECQSNCCVTTND;SECQSNCC;TCSEHSECQSNCC 3 13.7 1.0014 -0.99766 0 0 0 3.89685 0 0 0 0 0 0 0 0 0 8.51661 5.96855 A0A8C0PFG9 A0A8C0PFG9_CANLF Transmembrane protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ISVCIRNAIGKYDCFRE 1 11.6 0.98429 -0.24198 0 0 0 0 0 0 9.90916 0 0 0 0 0 0 0 0 A0A8C0PFH0 A0A8C0PFH0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AASSYLSLTPDK;ASSYLSLTPDK;KTTKPSKQSNNKYAASSY;KYAASSYLSLTPDK;LTVLGQPKA;NKYAASSY;NKYAASSYL;NKYAASSYLSLTPDK;NNKYAASSY;NNKYAASSYL;QSNNKYAASSYLSLTPDK;SNNKYAASSY;SNNKYAASSYL;SNNKYAASSYLSLTPDK;SSYLSLTPDK;STVEKKVAPA;SYLSLTPDK;TTKPSKQSNNKYAASSY;TTKPSKQSNNKYAASSYLSLTPDK;TVLGQPKA;TVLGQPKAS;TVLGQPKASP;TVLGQPKASPS;TVLGQPKASPSVTL;TVLGQPKASPSVTLF;TVLGQPKASPSVTLFPPSSEELG;YAASSYLSLTPDK;YLSLTPDK 28 48.8 0.97826 0.048313 0 0 0 0 0 0 0 0 5.35565 0 0 0 0 0 0 A0A8C0PFH5 A0A8C0PFH5_CANLF Presenilin (EC 3.4.23.-) PSEN1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563] axon [GO:0030424]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; synapse [GO:0045202] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]" QNAQMSEDNHL;SMHRHPDNGVLNENEDSS 2 6.5 0.98473 -0.25773 0 0 0 0 0 0 0 0 0 0 0 9.75952 0 0 0 A0A8C0PFI2 A0A8C0PFI2_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] AEHGAVDV;PGRRSRRRLSSRGCPQ 2 4.3 1.0039 -1.0552 0 0 0 5.81995 0 0 0 0 11.0132 0 0 0 0 0 0 A0A8C0PFI4 A0A8C0PFI4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) DPTPKRRRVL;MNEKGEITTNT;PKRRRVLIKIRAELN;TPKRRRVLIKIR 4 3.9 0.99266 -0.17073 0 0 0 8.7271 0 0 0 0 0 0 5.21308 0 0 0 0 A0A8C0PFJ7 A0A8C0PFJ7_CANLF Non-histone chromosomal protein HMG-14 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] GGGGGGGG;GGGGGGPG;GGGGGRPG;GGGGPGAAFWNVRR;VRGGGGGG 5 14.6 0.98561 -0.24601 0 0 0 0 0 0 9.71845 0 0 0 0 0 0 0 0 A0A8C0PFJ9 A0A8C0PFJ9_CANLF Mast cell expressed membrane protein 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PADKEGADNPDYE 1 7.1 0.94512 0.059637 0 0 0 0 2.80589 0 0 0 0 0 0 0 0 0 0 A0A8C0PFM4 A0A8C0PFM4_CANLF Leucine zipper tumor suppressor 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LVTPVGPT;QQLKESQTEINTKASEI;SGAILHSSPSASHQ 3 7.3 0.98544 -0.25845 0 0 0 0 0 0 0 9.93556 0 0 0 0 0 0 0 A0A8C0PFN7 A0A8C0PFN7_CANLF Zinc finger MYND-type containing 8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] EEEIKTEQEV;EGDWFCPECE;EVNTETLNKSSQ;LGLDSDSESELVI;SPVKKQRPLLPKE;TAGSQSPPETPLLTRSSSQTPTAG;VAADIAKYTSKMM;VIDLGEDHSG;YCWVCHREGQVLCCELC 9 10.7 1.0031 -2.1246 0 0 0 0 0 5.80952 14.6342 8.48164 9.96607 0 11.7912 0 0 0 9.80471 A0A8C0PFP5 A0A8C0PFP5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] FITVSALFSHN;GVELTCAYEALPLGFLFCSRDPVP;PRCLSAVPAPAPAQNPIPAPSL 3 6.9 0.98396 -0.24226 0 0 0 0 6.66661 0 0 0 0 0 0 0 11.473 0 0 A0A8C0PFQ5 A0A8C0PFQ5_CANLF C2H2-type domain-containing protein DPF3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872] CVSANTGAWIVEKPPA;GVAQNNCYIWMEKRHRG;HVDLRLLLLLLLLFLFP;LLLLLLLL;LSYHYAHTHLASE;RLLLLLLL;RLLLLLLLL;SVNSVTWGLRH 8 19.1 1.002 -0.68175 0 0 0 0 0 0 7.41304 0 0 0 9.53251 0 0 0 0 A0A8C0PFR0 A0A8C0PFR0_CANLF tRNA (guanine(9)-N(1))-methyltransferase (EC 2.1.1.221) TRMT10A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] DRKRIRRDV;EQRELRKQKRKEKRKRKQL;FFPISPGP;FSFFPISPGP;SDTAGTGP 5 11.2 1.0007 -2.7906 0 0 9.13748 4.88308 0 0 0 0 0 0 0 6.63722 0 0 0 A0A8C0PFR2 A0A8C0PFR2_CANLF Phospholipase (EC 3.1.4.4) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] FQEFHRELLKYKAFIRI;NGCKNPVHFQVVI;RELLKYKAFIRIPIPTR 3 3.3 0.99033 -0.26192 0 0 0 0 0 0 0 0 9.09199 0 0 0 0 0 0 A0A8C0PFR6 A0A8C0PFR6_CANLF Stathmin STMN4 Canis lupus familiaris (Dog) (Canis familiaris) microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; neuron projection [GO:0043005] tubulin binding [GO:0015631] LLKHLAEKREH;SLPRRRDPSLEEIQK;VIELNKCT 3 19.4 1.0014 -1.3152 0 0 0 0 0 9.03023 0 0 0 4.18634 0 0 0 0 12.259 A0A8C0PFT8 A0A8C0PFT8_CANLF Paxillin Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; cytoskeleton [GO:0005856] metal ion binding [GO:0046872] EIPHGATPSFQEV;GEAWAAGWPPNDRQSSPEGQ;STKTSSAP 3 3.8 0.98592 -0.4291 0 0 0 0 0 10.1772 0 0 9.52744 0 0 0 0 0 0 A0A8C0PFT9 A0A8C0PFT9_CANLF Mitogen-activated protein kinase (EC 2.7.11.24) MAPK1 Canis lupus familiaris (Dog) (Canis familiaris) caveolin-mediated endocytosis [GO:0072584]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] caveola [GO:0005901]; centrosome [GO:0005813]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] GGAVSGSC 1 2.1 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 8.99263 0 0 0 0 0 A0A8C0PFX2 A0A8C0PFX2_CANLF CUB domain-containing protein LRP12 Canis lupus familiaris (Dog) (Canis familiaris) CNSMDECGDGSDEEVC;EINCTMCQ;EVVPSQSTSREP;FQCLSRFTKVYTCLPESL;GASDFDVNDCSRP;GDGSDEENCPV;GVCYPRSDRC;LVSADGDEVVPSQ;NSMDECGDG;RKHKFSKTCGETPEQIRAPSG;SVESDDTDTENERRDTAGA;SWVCDSQDDCGDGSDEENC;TYQVDGFCLPWEIPCG;VCDSQDDCGDGSDEENCP;VESDDTDTENERRDTAGAS 15 18.3 0.99728 -3.8192 0 0 0 10.1135 2.39092 5.84827 10.953 0 8.92247 0 11.3707 0 10.9508 13.3856 12.2282 A0A8C0PFX9 A0A8C0PFX9_CANLF Phosphatidylinositol-specific phospholipase C X domain-containing protein PLCXD2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] phosphoric diester hydrolase activity [GO:0008081] IKRLARISLVKKLMKK;MTLQALWEKKCQVLIFYHCPFYK;VLIFYHCPFYKQYPF 3 14.1 0.85405 0.14955 0 0 0 5.69162 0 6.30431 0 0 10.2847 0 0 0 0 0 0 A0A8C0PG02 A0A8C0PG02_CANLF Condensin complex subunit 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALAYLLNDPQSACRR 1 4.4 0.94891 0.05391 0 0 0 0 0 0 0 0 8.95126 0 0 0 0 0 0 A0A8C0PG13 A0A8C0PG13_CANLF Epiplakin 1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament bundle assembly [GO:0045110]; wound healing [GO:0042060] cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; keratin filament [GO:0045095]; plasma membrane [GO:0005886] keratin filament binding [GO:1990254]; structural molecule activity [GO:0005198] EETEEQYRGMKV;ELVREYKEHVNQ;IDPTGHYHLPLPVAT;IITQETLTALAQ;IPMGFAVQMLEAQAA;LDNLAQGTKTPQEV;LVAEQAVTGYH;LVSDQRHMRKRFVDPNNQERVTYQ;QEQTLRAATME;VHLPEAVACRL 10 3.5 0.98491 0.035491 0 0 0 0 0 0 0 8.84709 0 0 0 0 0 0 0 A0A8C0PG20 A0A8C0PG20_CANLF Tripartite motif containing 35 TRIM35 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] VKDTAHDFRAKCRNMEHALRE 1 4.4 0.9847 -0.24626 0 0 0 0 0 0 0 0 0 0 0 0 9.03249 0 0 A0A8C0PG28 A0A8C0PG28_CANLF [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; zinc ion binding [GO:0008270] ATQCTCRK;HVICAIAERHPVDISA 2 2.2 0.95682 0.049233 0 0 0 0 0 0 0 0 6.55651 0 0 0 0 0 0 A0A8C0PG30 A0A8C0PG30_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRS Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] plasma membrane [GO:0005886] protein tyrosine phosphatase activity [GO:0004725] HGVPEYPTPFLAFLRRVKTCNPP;IMLADAQEMVITNLQ;IVIAILLYKNKPDSKRKD;KHNVDDSLLT;MQGAEDLT;PDRSLTLLSPCCPRQTI;TYTVRVLAFTSVGDG;VLGYRLQFGREDSP 8 5.8 1.0025 -1.1798 0 0 0 0 0 0 0 10.0111 11.0605 0 7.49193 0 0 0 0 A0A8C0PG32 A0A8C0PG32_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] AGLSFAFP;DIDHVRTNTNKSL;EEDNDDGDD;PSLATSQLSQKSRCPGCYQ;TLIKYQEVVEEL 5 17.6 1.0039 -0.80421 0 2.16717 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PG41 A0A8C0PG41_CANLF Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) GPD1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; NADH oxidation [GO:0006116] glycerol-3-phosphate dehydrogenase (FAD) complex [GO:0009331] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein homodimerization activity [GO:0042803]" GIPMSVLMGANIANEVADD;MVDKFPLFMAVYKICYE 2 10.3 0.92661 0.096129 9.46693 0 8.06248 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PG43 A0A8C0PG43_CANLF Thrombospondin 3 THBS3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] ADNDGVGDQCDDDA;CGTDTDIDGYPDQ;DECDGDDDN;DEDGVGDACDSC;DSFGDACDNCPNVPNNDQKD;DTDGNGEG;GALSECPFQ;GDECDGDDDNDGVP;GEGDACDNDVDGDGIP;PKVPNPLQTDRDE;RNTIMECQVCGFHEQRSHCSPNPCF;VGDACDSCPEMS;VGDQCDDDAD;YRWQLLHRPQV 14 17 0.99798 -3.33 6.89154 10.7923 10.4097 5.73985 5.80488 10.7486 4.50799 5.76887 6.54824 7.26604 0 8.41401 10.4285 8.30278 9.7443 A0A8C0PG44 A0A8C0PG44_CANLF L-lactate dehydrogenase A chain (EC 1.1.1.27) Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] VEVGAVGLDL 1 2.9 0.78457 0.22761 9.82758 0 10.5605 0 0 0 10.9253 0 10.6493 0 0 10.1577 0 0 0 A0A8C0PG47 A0A8C0PG47_CANLF Mediator of RNA polymerase II transcription subunit 13 MED13 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] DEVTNILQQPLALGY;KPMEDRIDSLSQSFP;LDSNQTSDVLRFVL;NKSEHLSC;NLILSESVMNLFKDC;QEDMDWEDDSL;QTELGETFGEAGQKY;TDLDNLFNSDEDE;VLVGCSMFAPLKS;VQMSSLPWR 10 6 1.0001 -0.61462 0 9.35977 9.88955 0 9.76742 9.41183 0 0 6.96463 7.64479 6.24945 0 7.74255 0 9.47259 A0A8C0PG65 A0A8C0PG65_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480] basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; presynaptic membrane [GO:0042734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] AYSVKKMMK;DPVRPEVP;LKFLKEAGHGNTKG;SELSIEQWLW 4 4.3 0.93211 0.06078 0 9.03119 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PG67 A0A8C0PG67_CANLF Glycosylphosphatidylinositol anchor attachment 1 GPAA1 Canis lupus familiaris (Dog) (Canis familiaris) GPI-anchor transamidase complex [GO:0042765] AASAGRER;EAHERYMVSGTNVY;STESLVLTVP;TESLVLTVP;VTSLDVAVEG 5 6 1.003 -1.7056 13.4966 0 4.20563 0 0 0 0 0 0 0 0 7.43771 10.626 0 0 A0A8C0PG78 A0A8C0PG78_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ELELQPLVFGLFLSMYL;EPGNLTGDSEFLLLGFSEELELQ 2 13.9 0.97691 0.046427 0 0 0 0 0 0 4.42479 0 0 0 0 0 0 0 0 A0A8C0PG81 A0A8C0PG81_CANLF Autoimmune regulator Canis lupus familiaris (Dog) (Canis familiaris) humoral immune response [GO:0006959] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; translation regulator activity [GO:0045182] GALEGILI;PGARKQAGGCYF;SFPKGRGEPGSCGARPP;SSGDVPGACGALEG 4 6.4 1.0036 -1.1087 0 0 0 0 0 6.67539 0 8.32966 0 9.46336 0 9.1428 0 0 0 A0A8C0PG85 A0A8C0PG85_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;LNEIETRRTVELINRTR;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.7 0.98307 0.046227 0 0 0 0 0 0 0 7.71129 0 0 0 0 0 0 0 A0A8C0PG95 A0A8C0PG95_CANLF U2A'/phosphoprotein 32 family A C-terminal domain-containing protein ICOSLG Canis lupus familiaris (Dog) (Canis familiaris) APDCGQPAPGLAEAGAA;TLSVNSVSSLEPVSQCQQ 2 8.6 0.26016 0.70994 15.8028 0 15.8295 0 0 0 15.7425 15.7561 15.7644 0 0 0 15.8186 15.9444 16.0012 A0A8C0PG96 A0A8C0PG96_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AELPTTLAETHQS;KAPPSPEEPKTEVVESI;KHKTTPTT;KRTWYKKFVGVQLCN;LKPKIPLI;QTHRPRPRPKPTP;RPFNSDSYSECKGKQYVKRTWYKKF;SELPESTL;TATYDVFSSPTPSDEP;VLHTAFEPVTLRT;VPPRRKPLP 11 8.3 1.0031 -2.2052 0 0 0 0 0 8.52912 0 9.21876 0 11.3375 0 9.64969 9.55526 11.2796 11.272 A0A8C0PGC1 A0A8C0PGC1_CANLF Major facilitator superfamily (MFS) profile domain-containing protein MFSD9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AVSTAVGRTCV;DLQLAAGGARAGGTVIGV 2 6.2 0.98536 -0.25332 0 7.26725 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PGC5 A0A8C0PGC5_CANLF Translation machinery-associated protein 7 Canis lupus familiaris (Dog) (Canis familiaris) SLSYPSNHSLSPCPGLCFLFF;TGRNRTPISSQGSQYH 2 20 0.93558 0.097756 0 0 0 0 0 0 0 0 10.4148 0 0 0 0 0 5.43533 A0A8C0PGD2 A0A8C0PGD2_CANLF FAS-associated death domain protein (FAS-associating death domain-containing protein) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; innate immune response [GO:0045087]; positive regulation of adaptive immune response [GO:0002821]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] LVADLIEEEQQARGLENESKTMSL 1 11.5 0.99148 -0.27634 0 0 0 0 10.5677 0 0 0 0 0 0 0 0 0 0 A0A8C0PGE7 A0A8C0PGE7_CANLF Coiled-coil domain containing 136 CCDC136 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ENEKNLEVVLHYKA;ESPNEKELLCRLQKLQLQYQHITCE;FLNEEYQAL;KNQDMKQVLWNEVVSVRSEPP;KPSPAPKPPIFSLPLVGLVVISALL;QELQHHRRTSE;TSEEEQRRLQ;TVNENCRRSYSSIDDSESY;YQALQESNSSLTGQLA 9 12.6 1.0023 -1.1703 0 11.7251 7.28633 0 8.89148 8.8559 0 10.5028 0 8.13837 0 8.53516 0 10.5069 0 A0A8C0PGF5 A0A8C0PGF5_CANLF "FERM, ARH/RhoGEF and pleckstrin domain protein 2" Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085] AVFFSRGSS;EAGGPHGS;FKRKRFLIKLHPEVRGP;NFCLFFYKTHQ;NWSRVRKLSFKRKRFLIK 5 5.6 1.0022 -1.4062 0 0 0 0 0 0 8.07607 0 0 0 0 0 0 0 0 A0A8C0PGH3 A0A8C0PGH3_CANLF ILEI/PANDER domain-containing protein FAM3B Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] carbohydrate binding [GO:0030246] THTGVPVIRGLR;VGVSHPGG 2 6.1 1.0026 -1.389 0 0 0 0 0 0 0 11.1647 0 0 0 9.97413 0 0 0 A0A8C0PGH9 A0A8C0PGH9_CANLF StAR related lipid transfer domain containing 13 STARD13 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] ATFHTYLEHLVQG;HRQGDDSDEE 2 2 0.98896 -0.26063 0 0 0 0 0 0 0 0 0 0 0 0 0 9.42897 0 A0A8C0PGI8 A0A8C0PGI8_CANLF PIG-P domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] AAVSPFPPSS;GGALGWFSHHPHLPPPTSRSPPWER;PVYLLIIILIGYVLLFGIN;SPLPERAIY;TNNQLFSAGNTI 5 11.9 1.0016 -1.2519 0 0 10.1156 0 0 8.67193 0 0 0 0 0 0 0 7.76388 9.56739 A0A8C0PGJ2 A0A8C0PGJ2_CANLF Bifunctional lysine-specific demethylase and histidyl-hydroxylase (EC 1.14.11.-) RIOX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506] LPLRPRKIRRQL;PGRALPAAA 2 3.3 1.0041 -1.0895 0 0 0 0 0 0 0 0 0 9.87549 0 0 0 5.9827 0 A0A8C0PGK8 A0A8C0PGK8_CANLF Uncharacterized protein LOC100688321 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] membrane [GO:0016020] LEESPHPRPLEE;LLLLLKVP 2 4.7 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 6.95548 6.69738 A0A8C0PGL0 A0A8C0PGL0_CANLF BUB1 N-terminal domain-containing protein BUB1B Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly checkpoint signaling [GO:0007094] kinetochore [GO:0000776] GVERARESERERERREYK;LERAVEALQGEKR;LKEEYDHLCSCYQYQD;LSLRAGSRRKLRRSA;LSLRAGSRRKLRRSAALK;PVPQQMQSNSRI;VFWDGSLWRLSQNL 7 7.9 1.0016 -0.99635 0 3.60916 0 0 0 7.37799 0 0 0 6.47776 0 6.1548 0 0 8.36602 A0A8C0PGL3 A0A8C0PGL3_CANLF Complement factor B (EC 3.4.21.47) (C3/C5 convertase) CFB Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; proteolysis [GO:0006508]" extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] AEDGHIPGEQQKRKIVLDPS;ELEKKLEYDQTL;LKEKLKNEDLEFL;LSEARPQGPCPLE;THARDFHVNLFQVTP;TPLSEARPQ;TPLSEARPQG;TPLSEARPQGP;YADPNTCK 9 10.8 0 7.4985 12.8313 12.9916 12.4246 12.7671 12.8677 12.8179 12.4098 13.941 12.8625 12.5878 12.5423 12.6718 13.2307 12.0531 13.6834 A0A8C0PGN5 A0A8C0PGN5_CANLF Protein ripply3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEEQEEETQS;STILGFSYHT;VENGPGGK;VGSADRRTGDGGARRASRAL 4 13.6 1.002 -1.4272 9.56008 0 0 0 9.67161 0 0 0 0 0 0 9.99492 0 0 0 A0A8C0PGP9 A0A8C0PGP9_CANLF Ig-like domain-containing protein CD19 Canis lupus familiaris (Dog) (Canis familiaris) B cell proliferation involved in immune response [GO:0002322]; regulation of B cell activation [GO:0050864] membrane [GO:0016020] ALGPEDEDSFSSAAESYENEDEEL;DEDSFSSAAESYENEDE;EPDSEEGSEFYENDSNRGQD;LETRRNNFHLPSLDF;LHLRRALILRRKRKRMT;SLDADSYENMDNPN 6 14.4 0.94195 0.060769 0 0 0 0 0 0 5.38243 0 0 0 0 0 0 0 0 A0A8C0PGQ5 A0A8C0PGQ5_CANLF Dehydrogenase/reductase 7 DHRS7 Canis lupus familiaris (Dog) (Canis familiaris) ELVYQLSKLG 1 4.8 0.99942 -0.61146 0 0 0 0 0 0 0 9.15537 0 0 0 0 0 0 0 A0A8C0PGS1 A0A8C0PGS1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AKTGRAGG;DVREAAKACPRSP 2 4.6 1.0039 -1.1044 0 0 0 0 0 0 0 0 14.2236 0 0 0 0 0 0 A0A8C0PGT9 A0A8C0PGT9_CANLF DNA replication licensing factor MCM4 (EC 3.6.4.12) MCM4 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] AEPSVCEHCH;DRYPDSILEHQIQV;ENFQRFLQHFIDPL;EQMEEEFMDMAVLKDYIAYAHSM;KGKTPALKY;LDEEAEQKLFSE;NLNPDDIDQLIAISGMVIR;PDDIDQLIAIS;SEEQMEEEFMDMAVLKDYIAY;VLHEVMEQQTLSIAKAGIICQ 10 15 1.0043 -1.092 0 10.2896 9.9635 7.29756 3.87774 0 0 8.20643 9.73154 3.41332 10.242 3.8748 6.30237 6.40506 7.63198 A0A8C0PGV2 A0A8C0PGV2_CANLF 40S ribosomal protein S15a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] CTFSLVEQPC 1 8.7 0.98971 -0.26223 0 0 0 0 0 0 0 0 7.86493 0 0 0 0 0 0 A0A8C0PGV4 A0A8C0PGV4_CANLF StAR related lipid transfer domain containing 13 STARD13 Canis lupus familiaris (Dog) (Canis familiaris) KLDVNFQRKKKGKAILL;VNFQRKKKGKA 2 11.4 0.98472 -0.24491 0 6.37008 0 0 0 0 0 4.26025 0 0 0 0 0 0 0 A0A8C0PGW1 A0A8C0PGW1_CANLF PKHD1 like 1 PKHD1L1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADAGLARNVEGEV;AGVEVFMGHFPCKVLSVNYT;AYGHILKGLPATV;ESEIKCQI;GLKLEIWNNSRPVHLEEILE;IPQWQSYQ;LEVTAMFP;LSWNTSKN;SECAIDRLKSDCTRLL;SPFQHRAVITL;TILTILGSG;TPWSSEAEFQ;TVLNLNINP;VGSSPGFNCSDVLTN;VGTAAQIMII;VIERDLSKITCRTPKVRE;VLNATYISLQGGRLIGGWEDN 17 5.1 0.99687 -5.7693 8.25314 0 0 4.79161 7.31732 0 11.298 0 9.55771 5.93871 7.65406 0 0 0 9.75005 A0A8C0PGX2 A0A8C0PGX2_CANLF D-aminoacyl-tRNA deacylase (EC 3.1.1.96) DTD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; tRNA binding [GO:0000049] DTQKELEHMVRKILNLR 1 8.1 0.97416 0.04706 0 0 0 0 0 0 0 0 0 0 0 0 0 6.77439 0 A0A8C0PGX5 A0A8C0PGX5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IFSDHNASKL;IVPCIFSDHNASKLE;MDAFLESHKL;MNEKGEITTNT;SQSEKEKHYMFS 6 5.2 1.0029 -0.97706 0 0 0 0 7.9148 0 9.9204 0 0 0 0 0 0 0 12.6753 A0A8C0PGY5 A0A8C0PGY5_CANLF XPA binding protein 2 XAB2 Canis lupus familiaris (Dog) (Canis familiaris) "blastocyst development [GO:0001824]; DNA-templated transcription [GO:0006351]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]" nucleoplasm [GO:0005654]; U2-type catalytic step 2 spliceosome [GO:0071007] ATKVSFKQVDDLAS;EDEDEDEM;EDEDEMDLEPNEVRLEQQS;GEDEDEDEMDL;KLWCSLADYYIRSGHFE;PQIVINYAMFLEEH;VNNCHERAFVFMH 7 9.4 1.003 -0.841 0 0 0 0 11.3106 11.3066 7.0706 5.52184 0 5.76705 0 4.40592 10.6224 0 0 A0A8C0PH05 A0A8C0PH05_CANLF Autophagy-related protein 11 C-terminal domain-containing protein RB1CC1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045] EAEKSKRESFGKL;EGLVHDEHLQ;LVHDEHLQH;METSMMSVQENIH;VQPCIFCIRSLCLP 5 3.3 1.0041 -1.0856 12.7926 0 12.7623 12.0761 11.3106 0 0 0 0 0 0 12.8047 0 0 0 A0A8C0PH12 A0A8C0PH12_CANLF K Homology domain-containing protein HDLBP Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] MDEFKLADVVDSE;VEKCTKYM 2 1.7 1.0033 -1.3358 0 0 12.1027 0 0 7.18854 0 0 0 0 0 0 0 0 0 A0A8C0PH27 A0A8C0PH27_CANLF DNA polymerase epsilon catalytic subunit (EC 2.7.7.7) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260] epsilon DNA polymerase complex [GO:0008622] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270]" GIKGNAPSSIHYGQ;HYGMSYLTETLEWLLQKNP;LDAETYVGGHVEALESG;LHRTLHNMMKKLFL;RRCVEVAEGEPLPG;SAFPVEITRRDDLVERPD;STELSSMFPALP;VGLKRNYIK;VGWVKEITQ;WWLLQVALPYE;YHRIQHQLESE 11 6.7 1.0042 -2.0219 7.63096 10.7093 11.9483 9.66058 8.28337 0 11.7703 0 11.5141 11.4966 11.5602 11.6239 8.58692 0 9.62044 A0A8C0PH28 A0A8C0PH28_CANLF Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 PCMTD2 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] AVRSLQDLARIAIRATIKKV;QKLDFFIRTSDSFDKFDFCEPSFVT;VLTHGAVGI 3 14.2 0.99761 -0.10319 6.75235 0 0 0 0 0 0 7.37747 0 0 0 0 0 0 0 A0A8C0PH35 A0A8C0PH35_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082] ASAEDIKKAY;DTPFEFGF 2 12 1.0023 -1.397 0 0 0 0 6.16251 0 0 0 0 0 0 0 0 0 0 A0A8C0PH38 A0A8C0PH38_CANLF F-box domain-containing protein FBXO16 Canis lupus familiaris (Dog) (Canis familiaris) LDQLWMLK 1 2.9 1.0048 -1.1044 0 0 0 0 0 8.2502 0 0 0 8.04603 0 0 0 0 0 A0A8C0PH76 A0A8C0PH76_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) BMPR1B Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; dorsal/ventral pattern formation [GO:0009953] plasma membrane [GO:0005886]; receptor complex [GO:0043235] "ATP binding [GO:0005524]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]" EIVCIKKL;ISDISIASIYFVLIVILDLKL;IVILDLKLYKLFLPG;NGSLYDYLKSTT;YHDLVPSDPSYEDMRE 5 10.9 0.99148 -0.54674 0 0 10.1018 12.0582 10.689 0 0 0 0 0 0 11.0965 0 6.88423 0 A0A8C0PH78 A0A8C0PH78_CANLF Ligand dependent nuclear receptor corepressor LCOR Canis lupus familiaris (Dog) (Canis familiaris) DADGFPIKPKSTDGMK;DDDDVDTVVDDQPKFVEW;DIFPSSDPISTV;ENQELIANFNA;GAPGGAGR;GGGGGGGG;LESSEQDSRPKQENHLHS;LVIVKKLNTRLPGDI;PSPMPAVHKASNGHSRTKM;SLFKDCERESISDWTF;TANTQDKDDNSDA;TESQPDTEDLQ 12 9.6 1.0031 -1.7163 0 10.7983 10.6682 0 0 6.78175 0 9.2032 10.9723 0 9.68489 0 11.3364 11.238 11.0319 A0A8C0PH86 A0A8C0PH86_CANLF Beta-adaptin appendage C-terminal subdomain domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131] AGRRAEALGRRP;VHGERIPNAPYVL 2 2.6 0.98472 -0.2577 0 0 0 0 0 0 13.112 0 14.1273 0 0 0 0 0 0 A0A8C0PHB1 A0A8C0PHB1_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EEAEEQQLLAPAAWR;IKHRLVSDVGAT;VGTAQTKIQ 3 11.2 0.98948 -0.52067 0 9.41081 0 0 0 0 0 0 0 7.55873 0 0 0 0 0 A0A8C0PHB2 A0A8C0PHB2_CANLF Kinesin family member 1A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; microtubule [GO:0005874]; synapse [GO:0045202] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DTSVAYVRGEEN;GLGDITDTNTVPGGPK;TEPLKNTGRG;TNITTEKVSKIS;VGEEEEEEEEEEEEEDLEDD;VPGGPKLTNALV 6 4.2 0.99016 -0.22214 0 10.1538 8.01391 0 0 0 0 9.76157 0 9.84259 0 11.4301 0 0 0 A0A8C0PHC2 A0A8C0PHC2_CANLF Par-6 family cell polarity regulator beta PARD6B Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein-containing complex assembly [GO:0065003] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleus [GO:0005634] GIEVSGKS;MEVKSKFGAEFRRFSLER;QSTDNSLLGYPQQV;VISMPQDFRPVSSI 4 14.6 1.0023 -1.1333 0 3.67785 8.62271 9.99081 0 0 10.0591 0 0 0 0 0 10.2 0 0 A0A8C0PHD8 A0A8C0PHD8_CANLF 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) PI4KA Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 1-phosphatidylinositol 4-kinase activity [GO:0004430] ANWRSKYISLSEKQWKD;GVSELHEQTRLSDQLHYCESIVKDF;LPRWDRPAATPH;PAGSAAARAMMAAAAARGGGG;SSGGGGGS;TAPGCGVI 6 4 1.0017 -1.2566 0 0 0 0 0 0 8.31886 0 9.74458 0 10.2946 0 0 0 11.4446 A0A8C0PHE5 A0A8C0PHE5_CANLF TEA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) embryonic organ development [GO:0048568]; hippo signaling [GO:0035329] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELFERGPSNAFFLVKFWADLNTNI;HIPGFLLSNSRPGGGQG;PAPPWQGRS;PGHPAVSGFWQGALPGQAG 4 8.7 0.99082 -0.21109 10.7536 0 0 0 0 0 0 0 0 0 0 0 10.3628 0 0 A0A8C0PHF1 A0A8C0PHF1_CANLF Trafficking protein particle complex 10 TRAPPC10 Canis lupus familiaris (Dog) (Canis familiaris) Golgi vesicle transport [GO:0048193] TRAPPII protein complex [GO:1990071] AGYLPLPDVRLF;EVMPLFAGYL;LDFQLSDGNLVDTGSSGDLQLVPLN;LLASDHHLTEEER;PFLHIYWTECCDTEVYK;PIVTCAGDQNLFTSIYPTLSQ;PQLHVEPLADSL 7 8.8 1.0036 -1.6361 0 6.30838 9.05834 0 11.9699 0 9.37797 6.83466 6.9991 5.02636 0 0 5.28188 6.51666 0 A0A8C0PHI6 A0A8C0PHI6_CANLF KATNIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ARRTGWGVGGSLPSGP;DEFLQQQKGSRHGEQ;FDLPTTVSMI;GGCGDCCGA;HKREGDSTTMAVLTRGGRAG;LELYDERGEKIPLSE;LSVNLQRKQKDGSSDE;NITMEDEHMWL;PASGRRGPRKDTL;PISLHQITA;QLNFTASWGDPHYLGLTGL;QQRNRILKHLKTKDPMQLR;QTLRKGDRSRSCSREKKEAYT;RILKHLKTKDPMQL;WNYNKSPEDTYRGAKIVHISLDGLC 15 10.4 1.0029 -0.75566 11.0388 12.3698 10.3606 11.6042 10.3454 9.94248 10.9407 11.891 13.8437 11.1959 10.7185 11.6689 11.3973 10.8947 11.799 A0A8C0PHJ3 A0A8C0PHJ3_CANLF "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" PISD Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540] lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743] phosphatidylserine decarboxylase activity [GO:0004609] DLHHYRNLSEFF;QKWDSYLGLWEPVP 2 6 0.91878 0.11382 0 0 0 0 0 5.89654 0 0 10.0229 0 0 0 0 0 0 A0A8C0PHJ4 A0A8C0PHJ4_CANLF Protein kinase domain-containing protein HIPK1 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; PML body [GO:0016605] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] CFQHKNHTCLVFEMLEQNLY;DSPDSDSSLSSPYST;ETGIKSKEARK;ISQTQGLPAEYLL;KRSTKEIVAIKILKNHPSYA;LVSQLCTGLNTEELSRVAK;PTGYRVPRGGT;SLLEPYQKCGLKRKS;VPGVAQQG 9 12.1 0.99263 -0.16945 0 0 0 0 0 0 11.094 0 0 0 0 0 0 0 0 A0A8C0PHQ4 A0A8C0PHQ4_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693] cell cortex [GO:0005938]; intracellular non-membrane-bounded organelle [GO:0043232] metal ion binding [GO:0046872] AADLQRFKRDVTE;DDLLFEKLLTPEG;DLLFEKLLTPE;EAYDLFQFFQDLDDEESW;EGAQIQQELNTRWDSLQ;EIDSYDDRFQ;ETERLVADDHYAK;IKARQESLV;KEASLKTNGNST;LEHWLREAEQQAAAE;LEKAWEQRKRMLDQ;QEKEPIVD;QERGALLLRVLK;QIKALNVP 14 6.9 0.98438 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 9.99605 0 0 A0A8C0PHT2 A0A8C0PHT2_CANLF Protein kinase domain-containing protein CDKL5 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of axon extension [GO:0045773]; regulation of dendrite development [GO:0050773] dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LNSVLLDLMKNLLKL;LVFEYVEKNMLEL;VGSFYRVPS;YIYQLIKAIHWCHKND;YVATRWYRS 5 7.8 0.98819 -0.47627 10.6341 7.65778 0 0 0 0 10.1253 0 0 0 0 0 0 0 0 A0A8C0PHT3 A0A8C0PHT3_CANLF FHA domain-containing protein SLMAP Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659]; regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900825] extracellular space [GO:0005615]; membrane [GO:0016020] EIQHLRKEL;GVDVTENTRKVTHG;HKTGKFYL;VQKEYEKTQT 4 5 1.003 -1.3797 0 0 0 0 0 0 0 0 9.29 0 0 0 0 0 0 A0A8C0PHT4 A0A8C0PHT4_CANLF Myozenin 1 Canis lupus familiaris (Dog) (Canis familiaris) Z disc [GO:0030018] ITVFKTYISLWER;VSEPLVLYNQ 2 16.8 0.99272 -0.55172 0 0 0 7.1374 0 4.32323 0 0 0 0 0 0 0 0 7.7237 A0A8C0PHT5 A0A8C0PHT5_CANLF NADH:ubiquinone oxidoreductase complex assembly factor 6 NDUFAF6 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] mitochondrial inner membrane [GO:0005743] KDLHADHAAS 1 4.1 0.99884 -0.61146 0 0 0 0 0 0 0 0 0 7.99067 0 0 0 0 0 A0A8C0PHT6 A0A8C0PHT6_CANLF Methylcytosine dioxygenase TET (EC 1.14.11.80) Canis lupus familiaris (Dog) (Canis familiaris) 5-methylcytosine catabolic process [GO:0006211]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; regulation of gene expression [GO:0010468] chromosome [GO:0005694]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270] ELFAGNKTQNLHH;KVRMLAEPVKT;LFDHKALTLKS;QQQKLQMKNKEQMPQTFSQSQ;RCFQEQEQKPQQ;TFSQSQDNNDQQ;VEAQEKKKQ 7 4.5 1.0022 -0.74036 6.44629 10.8499 0 0 0 0 0 0 10.6593 0 0 0 0 0 8.89227 A0A8C0PHU9 A0A8C0PHU9_CANLF TEA domain-containing protein TEAD1 Canis lupus familiaris (Dog) (Canis familiaris) embryonic organ development [GO:0048568]; hippo signaling [GO:0035329] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DPDSYNKHLFVHIG;KQDQTAKDKALQ 2 7.1 0.99334 -0.55696 0 0 0 0 0 0 8.97616 0 0 0 0 0 0 0 0 A0A8C0PHW6 A0A8C0PHW6_CANLF Zinc finger protein 425 ZNF786 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FVCRKVFKLKSDLVKHT;HTKEKPFSCSECSRSFSRHSH;QVMKNNYETLDSLGRVFSKPD;YQQVMKNNYETLDSLGRVFSKPDL 4 8.2 1.0022 -0.68693 5.49346 0 0 0 0 0 0 0 13.1613 0 0 0 0 0 10.8311 A0A8C0PHW9 A0A8C0PHW9_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LPRLPRLPRLRRRRSSP;LRRLPRLPRLPRLRRRRSSPARAAP 2 6 0.97966 0.035538 0 0 0 6.89081 0 0 0 0 0 0 0 0 4.12143 0 0 A0A8C0PHX6 A0A8C0PHX6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NGEAEVVRK 1 10.6 1.0041 -0.80421 0 0 0 0 0 0 0 0 0 0 8.3378 0 0 0 0 A0A8C0PHX8 A0A8C0PHX8_CANLF Fidgetin like 2 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGGLAKKKKRKKKKKEK;GGLAKKKKRKKKK;GGLAKKKKRKKKKK;GLAGGGLAKKKKRKKK;GLAKKKKRKKKKK;GVPGRRRRRRRR;KKKKRKKKKKEKK;KKKKRKKKKKEKKE;KRKKKKKEKKEKEKKHPKKGFCLF;LAKKKKRKKKKK;PHPAVSLGLAGGGLAKKKKRKKK;RKKKKKEKKEKEKKHPK;RRPLPRRGRRRLSGQRVPAQ;SQWPEQHLDVSST 15 9.8 0.93561 0.06874 0 3.34383 5.53835 0 3.51916 6.48099 6.47046 7.77854 0 0 8.57342 6.39141 3.31059 6.66078 0 A0A8C0PI25 A0A8C0PI25_CANLF Erythroblast membrane associated protein (Scianna blood group) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EQVMEVGNHELQ;VTATPANGHWLVRQSS;VTRDGSVTLQVAAPSP 3 10 0.99096 0.0021163 0 0 9.29069 0 0 0 0 0 0 0 0 0 10.7337 0 8.81285 A0A8C0PI26 A0A8C0PI26_CANLF "Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial)" MRPL16 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] SLGEGRGG 1 1.9 0.98955 -0.26546 0 0 0 0 0 0 0 0 0 0 8.4795 0 0 0 0 A0A8C0PI27 A0A8C0PI27_CANLF "D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)" Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824]; FAD binding [GO:0071949] GPWGAVGN;VGGSVPVFDEI;VYEWTAGQRGSI 3 5.6 0.94593 0.05044 0 0 0 0 0 0 0 0 0 8.08624 0 0 0 0 0 A0A8C0PI39 A0A8C0PI39_CANLF 40S ribosomal protein S3a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] RWHKRSQEESTMIE 1 7.7 0.93619 0.060938 0 0 0 8.99783 0 0 0 0 0 0 0 9.46946 0 0 0 A0A8C0PI70 A0A8C0PI70_CANLF Cyclin E2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082] cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] FYLAQDFFDRFMLTQ;GAGGGGGG;GGGGGGGA;GGGGGGGG;VLSGGISP 5 5.1 0.98596 -0.4342 0 0 0 0 0 9.22074 11.937 0 0 0 0 0 0 0 0 A0A8C0PI76 A0A8C0PI76_CANLF Serum amyloid A like 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LHEVDKTLADDL;LLPFYSPVI;PQEDSEEQPVFRIV 3 7.4 1.0019 -0.69267 0 0 0 0 0 0 0 0 0 0 9.85866 0 10.3679 0 0 A0A8C0PI94 A0A8C0PI94_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ETEILYTTERDLREVF 1 10.7 0.98543 -0.23616 0 0 0 0 0 0 9.31476 0 0 0 0 0 0 0 0 A0A8C0PIA0 A0A8C0PIA0_CANLF Ion transport domain-containing protein TPCN1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] monoatomic ion channel activity [GO:0005216]; voltage-gated channel activity [GO:0022832] AYLFAHNHLFYLME;DLSLKMYQEEIQEWYEEHARKQ;IVVLRPLQLLRLFKL;IVVLRPLQLLRLFKLKKR;IVYLSIELYFI;LTLDEGGSAPLA;NYQEAAIYLQ;VLRPLQLLRLFKLKKRYRNVL;YFIVVLRPLQLLRLFKLKKRYR 9 11.8 0.98959 -0.21674 0 9.06824 0 6.83668 9.6469 8.87642 10.0182 9.88347 0 0 0 0 0 0 0 A0A8C0PIC7 A0A8C0PIC7_CANLF Attractin ATRN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGLRLPRRRLLLLLLPPLL;CMEWYTMSSCPPE;CNSSDDRGCSCFPEW;FMAYDLAC;GAGLRLPRRRLLLLLLPPLLLLP;LGAGLRLPRRRLLLLLLPPL;LGAGLRLPRRRLLLLLLPPLLLLPW;LLLLPPLLLLPW;LRLPRRRLLLLLLPPLLLLPW;NDCHWCSDHC;NTVQCECLENWKGEACDVPHCVHDC;PDEQNRDLDMFIN;PLYGYISNVQEYD;TACGECTSGSSECMWCSN;TDCYSCTANTNDCHWCSD;TDGPGNYKYKTKCTWLIEGQPNRIM;TMSSCPPENCSGYCTCSHCLE;VENRYQGNPLKGTC 18 15.7 1.0028 -1.3464 0 11.4557 13.154 7.7254 14.8846 14.9551 7.3753 9.25493 7.93363 7.06803 0 7.82991 0 6.78529 9.6262 A0A8C0PIC9 A0A8C0PIC9_CANLF Patatin like phospholipase domain containing 6 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470] endoplasmic reticulum membrane [GO:0005789] lysophospholipase activity [GO:0004622] AGVAVLVTAVLILLLVRR;CCLVAGEESDCLTEYEEDAGPD;GVAVLVTAVLILLLVRRLRV;GVAVLVTAVLILLLVRRLRVPK;GVMIGAGVAVLVTAVLILLLV;GVMIGAGVAVLVTAVLILLLVRR;GVMIGAGVAVLVTAVLILLLVRRL;GVPPHSELTNPAS;IDCFKTMDFGKF;IVGLGDQEPTLGQ;LILLLVRRLRVPKT;LVRRLRVPKTPA;SSACCYSCDPPGS;TAVLILLLVRRLRVPKTP;VAVLVTAVLILLLVRRL;VLILLLVRRLRVP;VLVTAVLILLLVRRLRV 17 6.8 0.98785 -0.48347 0 0 0 0 0 0 0 0 5.44059 0 9.24899 0 0 12.4565 0 A0A8C0PID1 A0A8C0PID1_CANLF Testis expressed 29 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PSHLLKKFAVCD;SPSHLLKK;SVEDAIVTIMGE 3 14 1.0025 -1.14 0 0 0 10.4666 0 0 0 12.8952 0 0 0 8.95638 0 0 0 A0A8C0PIE2 A0A8C0PIE2_CANLF AMP deaminase (EC 3.5.4.6) AMPD1 Canis lupus familiaris (Dog) (Canis familiaris) IMP salvage [GO:0032264] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] LPAKEKQI;LPHFGKMLENVFMPVFEATI;LSHIDEYI;LSTWFVRNRIYCHNMT;MHPYDLTVDSLDVHAGRQTFQRF;PATMPLLKLPA 6 10.7 0.98981 -0.223 8.89533 0 13.2284 0 0 0 0 0 10.8326 0 9.68904 6.90797 10.2885 0 13.2697 A0A8C0PIE4 A0A8C0PIE4_CANLF Collagen type XVII alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AGEPGVQGPPG;EAGAFGLDMGLG;GAAEGGMY;GASGGSLGE;GEHGGMGQ;GGGGGGGG;GVSSIPGP;GYGGAAEG;LETYFSGP;LLLTWLLLL;LPAGSSMGT;VIGDWSLQSLDYAEL;VLETYFSG 13 7.3 1.0039 -1.1044 0 0 0 0 9.71015 0 0 0 0 0 0 0 0 0 0 A0A8C0PIE5 A0A8C0PIE5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HDIELEVHTPSLL 1 7.6 0.98353 -0.2554 0 0 0 0 0 0 9.44855 0 0 0 0 0 0 0 0 A0A8C0PIE9 A0A8C0PIE9_CANLF Actin binding LIM protein 1 ABLIM1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737] actin binding [GO:0003779]; metal ion binding [GO:0046872] GVRDYQTL;HYHPSCARCSRCNQM;PGNEPSSGRNSPLPYRPDSR;QDPHHPSEKPVIHCH;YHPSCARCSRCNQMFTEGE 5 8.1 1.0025 -1.4808 10.6889 0 0 0 0 8.31134 0 0 0 10.29 0 10.0101 10.4663 0 0 A0A8C0PIF5 A0A8C0PIF5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;ARVILKKKTI;LRFVWNQKRPRIARVILKKKT;MDAFLESHKL;MNEKGEITTNT 5 5.9 0.98797 -0.22766 0 0 0 0 7.84367 0 0 0 0 9.33483 0 0 0 0 0 A0A8C0PIF7 A0A8C0PIF7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MWFMYTMEYYSAIRNDKYS;NQKRPRIARGILKKKTISGGII;WNRIETPEVDPELY 3 8.1 0.85056 0.15706 8.36194 0 0 0 0 0 0 0 0 0 0 0 5.52885 0 0 A0A8C0PIH2 A0A8C0PIH2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TNIK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DEESSAAALFTSELLR;DYSSSSEESESSDEEEE;EGCIHYKVVKYERIKFLVI;ELRKQQEREQRRHYEEQMRREEERR;ERTRVRAN;ESSDEEEEDGESETHDG;ETEYEYSGSEEEEEENDS;FFASVRSGG;FIGTPYWMAPE;HYKEGMSPSEKPAWAKEVQHRPFN;LEGCIHYK;LLAERQKRIEEQKEQRRRLEE;NLPDLVQQSH;NSPGNGSA;NSSVLPGQAPS;PTDEDEEDEE;QLEEEQRQLEI;SSSEESESSDEEEEDGESETHDGT;VLPAKQNHSAVR;VNLTTLTSWLSSY 20 14.4 0.99703 -3.635 10.1357 8.25106 10.518 8.41223 6.19558 9.86456 12.3342 14.6833 10.2915 11.1623 0 10.6381 12.5458 9.11351 12.578 A0A8C0PII5 A0A8C0PII5_CANLF Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) ADRB1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart contraction [GO:0045823] plasma membrane [GO:0005886] beta1-adrenergic receptor activity [GO:0004940] AASDDDDDDDD;AASDDDDDDDDEDDA;DDDDDDDDEDDAGAGA;GAASDDDDDDDDEDDAGAGAAP;HWWRAGGDEARRCYNDPKCCD;IVLLIVAGNVLVIAAIAKTPRLQT;LMHWWRAGGDE;MHWWRAGGDEARRCYNDPKC;SDDDDDDD;SDDDDDDDD 10 14.5 0.97321 0.046699 6.55963 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PIJ5 A0A8C0PIJ5_CANLF Potassium voltage-gated channel subfamily A member 1 KCNA1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to magnesium ion [GO:0071286]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; hippocampus development [GO:0021766]; magnesium ion homeostasis [GO:0010960]; membrane repolarization during action potential [GO:0086011]; neuroblast proliferation [GO:0007405]; neuronal action potential [GO:0019228]; protein homooligomerization [GO:0051260]; startle response [GO:0001964] axon initial segment [GO:0043194]; axon terminus [GO:0043679]; cell surface [GO:0009986]; dendrite [GO:0030425]; juxtaparanode region of axon [GO:0044224]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; disordered domain specific binding [GO:0097718] EHDDHECCE;IFFLFIGVILFS;SLAILRVIRLVRVFRI;SLAILRVIRLVRVFRIFKLSRHSK;TSLAILRVIRLVRVFRIFKL 5 9.3 0.98945 -0.22374 0 0 0 0 0 0 0 0 0 5.04247 0 4.00018 0 0 0 A0A8C0PIJ6 A0A8C0PIJ6_CANLF Anaphylatoxin-like domain-containing protein LOC481722 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]" extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] AIHTEEIVYELNPLDH;DDPDASSQTVTPLEL;DDPDASSQTVTPLELFERRRN;FSLGSKINV;GSKGVLSPGGL;GSKGVLSPGGLASL;IVYELNPLDHRA;KPRLLLFS;KPRLLLFSPSVVHL;KPRLLLFSPSVVHLG;KPRLLLFSPSVVHLGVPLSVG;LSIERPDPRPPRVEDTLNL;LVSAGSPHPAVARL;NLRAVGVSGD;NVNFQKAIHEKLGQYA;PDASSQTVTPLEL;PDASSQTVTPLELFE;PDASSQTVTPLELFERRRN;PHVLLYFDSVPTSRECVGF;PNIIPDGDF;PNIIPDGDFSSL;PRPPRVEDTLNL;PRPPRVEDTLNLNL;PVASGLCA;QDEAGYRMRFA;SHELQLNNHQVQGLEEELQF;SKGVLSPGGLASL;SLGSKINV;SSDPNIIPDGDFSSL;SSLVRVTASHPLDT;STLPPETKDHAVDL;SVVPTAATAVSL;TLEIPGSSD;TLEIPGSSDPNIIPD;TLEIPGSSDPNIIPDG;TLEIPGSSDPNIIPDGD;TLEIPGSSDPNIIPDGDF;TLEIPGSSDPNIIPDGDFSSL;TREANEDYEDYV;TVRAPPSGSSRF;TVRAPPSGSSRFLSIERPD;VALGAMDMAL;VQLLVSAGSPHPAVARL;VRVTASHPLDT;YHPGETVKLHLQTDSP 45 18.5 0.98811 -0.26458 0 0 0 0 0 10.9964 0 0 0 0 0 0 0 0 0 A0A8C0PIK5 A0A8C0PIK5_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALLECLLTPDNVPSDSPKE;AYICSLEVFQITLTE;EMLQVQESTH;ENCWKFFLARVQL;EVEDSLEKVQVA;EVHHLRTATPA;GFNAKNPYTVLDKLLEE;GNAGTGKS;HDAIRNRKKRFVF;IKITNEPP;IKNVLDATCRPN;KKKSLIQKLIILRAVR;KNVSDDILEKLPEE;LDTWKIYVEFID;LVYFIDDM;MAHVHTSVNEMSTRYYQNERR;NYGQKMPEQVYIQLE;PLFHTICLIWSH;QAEFRERFRLYAP;SELAHRVEHT;TYVTRSIDN;YQVYCDVEPKRQAL 22 6.6 0.95805 0.051237 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.93298 A0A8C0PIK9 A0A8C0PIK9_CANLF RAVE complex protein Rav1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DESIHSDEEEDDHQDPNSYS;DSALEEEEEDAV;GGDILEEEEEIDNK;GGSEWVLEQTIHLDDLVKVG;HSDEEEDDHQDPNSYSW;LILWRVDPIGPLS;LSSVTYNLAWDPQ;NIKHLVHLDWV;NLLSSAQDEDQPKLNILLCEAVVA;SIIPQDHHEVKRR;SLPGLTRLEQMF;STHDVQELDVT;TIHHLKNL;VLASTHDVQELDV;VLDSRVSVDSNLFV;WDPQDNRLLTATDSIQ 16 6.9 1.002 -1.3639 0 0 11.9605 0 7.00011 8.65914 9.30645 7.19407 7.21868 0 9.12469 0 6.76911 9.00087 12.6781 A0A8C0PIL3 A0A8C0PIL3_CANLF Zinc finger and BTB domain containing 46 Canis lupus familiaris (Dog) (Canis familiaris) AGPLDSGG;EDPDDPRGDGEEELC;GPAHRRGAARAARSGPLAPAG;GVTGKRRRLIVRAAGP;NSSGDSAIASCHEGGSSYGKEDQE;PPGPGPAD;TPGPGGGP;VGIKHGSRRHGVCADCAGRGV;VGLAHEDALLA 9 9.8 1.004 -1.9739 0 5.32359 0 11.0559 0 11.0296 9.3872 10.0049 0 0 2.73732 7.58301 5.80516 0 9.56081 A0A8C0PIM7 A0A8C0PIM7_CANLF TOG domain-containing protein GCN1 Canis lupus familiaris (Dog) (Canis familiaris) EDLLPWLMETL;GVPGLEGDVTNTEQLAQ;IGSVSHHVVSGPS;ISTITASVQNPALCQ;KVGIALKPFLPQLQTTFTK;LADENEFVRDTA;MLCTMLGKLFEPYVVHVLPH;SAKALGAMVK;VHIVFPSRAKRQGDIWN;VPGRGAST;YAERKGAAYGLA;YALDIVKGLASQ 12 6 1.0032 -2.3972 8.28628 0 0 0 7.96642 0 0 10.2751 9.82579 12.7832 9.424 0 5.31622 9.15066 0 A0A8C0PIN4 A0A8C0PIN4_CANLF "Acylphosphatase-2 (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)" Canis lupus familiaris (Dog) (Canis familiaris) acylphosphatase activity [GO:0003998] NTSKGTVTGQVQGPEDKVN 1 22.9 0.95322 0.049524 0 0 0 0 0 0 0 0 0 0 0 0 6.88716 0 0 A0A8C0PIS7 A0A8C0PIS7_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AYDRFVAICHPLHYMVIMNPRV;VGSDSHLHTPM 2 10.8 0.96543 0.048416 0 0 0 8.12138 0 0 0 0 0 0 0 0 9.80487 0 0 A0A8C0PIV4 A0A8C0PIV4_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KVDSFYCDFPKI 1 4.7 0.98539 -0.2354 0 0 9.49773 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PIV5 A0A8C0PIV5_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALLECLLTPDNVPSDSPKE;AYICSLEVFQITLTE;EMLQVQESTH;ENCWKFFLARVQL;EVEDSLEKVQVA;EVHHLRTATPA;GNAGTGKS;HDAIRNRKKRFVF;IKITNEPP;IKNVLDATCRPN;KKKSLIQKLIILRAVR;KNPYTVLDKANQELELLEEEMLQV;KNVSDDILEKLPEE;LDTWKIYVEFID;LVYFIDDM;MAHVHTSVNEMSTRYYQNERR;NYGQKMPEQVYIQLE;PLFHTICLIWSH;QAEFRERFRLYAP;SELAHRVEHT;TVLDKANQE;TYDPSDYNNMVTL;TYVTRSIDN;YQVYCDVEPKRQAL 24 7 0.98941 -0.19729 0 0 0 0 0 12.5749 0 0 0 0 0 0 0 0 0 A0A8C0PIW7 A0A8C0PIW7_CANLF Cysteine sulfinic acid decarboxylase Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carbon-carbon lyase activity [GO:0016830]; pyridoxal phosphate binding [GO:0030170] SEQILARCRAV;SPRASTPASECPGPG 2 7.1 0.93286 0.099591 0 0 0 0 0 5.29186 0 0 0 0 0 0 0 0 0 A0A8C0PIX4 A0A8C0PIX4_CANLF Ankyrin 2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] DEEGDDTMTGDGGE;DLQISPDRKTSTDFSDVI;EDELNEILNGMDE;EDQQDEQERIEE;ESDQEQEEEIDM;FSPKKSEEQVGE;GFGGDAPT;HYCEYTED;LDVSRVESLQGD;LEHLEDVPEALDQDDLQRDLQ;LGIKKPVRRKLKEKQ;LPALSLQNGALDGSPESLKPEGVP;QLERELVEEEWVIVSDEE;RRKLKEKQKQKE;SPDRKTSTDFSDVIKQ;SVLQEELNTAQHKQKEEQGAS;SWTELARELDFTEEQIHQIRIEN;VVKKVTRKIIRRYVSS 18 6.7 1.0036 -2.3893 12.3991 0 7.16571 12.7116 3.97911 7.33557 10.8082 13.9455 8.73884 9.23168 9.69848 8.03628 0 0 0 A0A8C0PIY4 A0A8C0PIY4_CANLF Cilia and flagella associated protein 46 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] EFDPTESFSPDLFVL;PGGGCGGGA 2 4.3 1.0044 -0.80421 0 9.5884 0 0 0 0 0 0 0 0 0 0 2.97431 0 0 A0A8C0PIZ6 A0A8C0PIZ6_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EQLVNFHSTPLAIPSFFTTVWTFA 1 7 0.99329 -0.28609 0 9.30072 8.77992 0 0 0 0 0 0 0 0 0 9.01851 0 0 A0A8C0PJ07 A0A8C0PJ07_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) EIF2AK4 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077] ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694] CLDDKERWSPQQLLKHSFIN;DDDDDDEHEGVFS;DLEEIIGLLKKLGIKLQVLINL;DVVHKVLNASNVLVDAEGNV;EAVHYLYIQ;EEDDDDDDE;HCGEQREILHEIQRRKEEIKEERKR;LKDLEEIIGLLKKLGIKLQVLINLG;LSRLHHENIVR;SLCSSEDSS;TYVALVSD 11 8.9 1.0013 -0.74465 0 0 0 4.32704 0 0 0 6.25778 0 0 0 0 0 0 0 A0A8C0PJ14 A0A8C0PJ14_CANLF Rho GTPase activating protein 25 ARHGAP25 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] IPFTRSRSV;LRNVERSREDVE;TPSGAVFGQRLDETVAY 3 6 0.99149 -0.54854 0 10.0049 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PJ19 A0A8C0PJ19_CANLF G-patch domain containing 2 GPATCH2 Canis lupus familiaris (Dog) (Canis familiaris) DDEQSDWFYEKESGGACGIT;FTKNKVKKRKLKIIRQGPKI;KKRKLKIIRQ;KNKVKKRKLKIIRQGPKIQ;KPNAPEYGLDTWVRPWTRWQGDR;VKKRKLKIIRQ 6 13.6 1.003 -1.0059 0 0 0 12.9505 4.1292 0 11.1537 0 0 0 0 0 0 0 6.01027 A0A8C0PJ22 A0A8C0PJ22_CANLF RAD9-HUS1-RAD1 interacting nuclear orphan 1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077] nucleus [GO:0005634] FVKEGPVPPGQ 1 4.5 0.98494 0.035491 0 0 0 0 0 9.81287 0 0 0 0 0 0 0 0 0 A0A8C0PJ37 A0A8C0PJ37_CANLF Phospholipase B-like (EC 3.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] phospholipase activity [GO:0004620] LEWVRNVVANRLAL 1 2.6 0.98506 -0.24635 0 8.90872 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PJ55 A0A8C0PJ55_CANLF RAVE complex protein Rav1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) vacuolar acidification [GO:0007035] RAVE complex [GO:0043291] AEEELLNMLPAMQKED;ATYKSILRKKVL;DDDDDDDDDDDD;DDDDDDDDDDDDVL;DDDDDDDDDDVLASDFHLQ;DDDDDDVL;DELFQIPTL;DLNLGDWRCIWHSVT;DSEESLESDDDDDDDDDDDDD;DSEESLESDDDDDDDDDDDDDV;ESDDDDDDDDDDDDD;ESLESDDDDDDDDDDD;HPLQLLELMDLGKVRRAK;ITSLSLSENNEKSGP;KRCLNESLEDNCET;LESDDDDDDDDDDDDDV;NPGDHCFSVGSVGDQRFTAY;RCRNERMNLEYVWEEWPLLIEDGL;SDDDDDDD;SDDDDDDDD;SDDDDDDDDDDDD;SELARINSLHVSAFS;SLESDDDDDDDDDD;SLESDDDDDDDDDDDD;SLESDDDDDDDDDDDDDV;TDSLSTLDENDIL;WHVDWLDEYQPGM;WSKNADMLFSI;YCSDGEDL;YDSEESLESDDDDDDDDDDDDD;YVMHTLAA 31 8.9 0.99793 -3.3341 4.77637 9.73862 12.0352 12.6027 4.776 9.81826 10.668 9.73215 9.45914 4.48091 0 9.39885 10.2583 7.15492 8.3821 A0A8C0PJ57 A0A8C0PJ57_CANLF carbonyl reductase (NADPH) (EC 1.1.1.184) Canis lupus familiaris (Dog) (Canis familiaris) carbonyl reductase (NADPH) activity [GO:0004090] GWPDMKLVTYGISKMG;SDGYYLLI 2 6.2 1.0037 -1.0552 0 9.286 0 0 8.01341 0 0 0 0 0 0 0 0 0 0 A0A8C0PJ90 A0A8C0PJ90_CANLF Ribosome binding factor A Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] LLCTPEVSQEICDLDVQLS 1 5.9 0.95176 0.049872 0 0 0 0 0 0 0 0 8.21922 0 0 0 0 0 0 A0A8C0PJA4 A0A8C0PJA4_CANLF inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) INPP5A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] inositol-polyphosphate 5-phosphatase activity [GO:0004445] AEPENLQKNWLREFYQVVHTHKPH;KGFVRTRWCVAD 2 8.8 0.97367 0.041303 0 0 0 0 0 8.25049 0 0 0 0 0 0 0 0 0 A0A8C0PJA5 A0A8C0PJA5_CANLF Integrator complex subunit 12 (PHD finger protein 22) INTS12 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AEKMKSDITEGVDIPK;RQMTVASGNQLVECQECHNL;TAKLSSATQNNSGKPATSSTN 3 12.8 0.99279 -0.14105 0 0 0 0 0 10.8596 0 8.11187 0 0 0 0 8.67419 0 0 A0A8C0PJB7 A0A8C0PJB7_CANLF UBX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CRTPEPPSPRHFS;EAQMAAAAALARLE 2 5.9 0.99444 -0.19098 0 0 6.38719 0 0 0 9.85756 0 0 0 0 0 0 0 0 A0A8C0PJB9 A0A8C0PJB9_CANLF FAM83 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGGPQDTVGVAPVEH;EAAAAADERGPRA;GCHGDDAGDEG;LQMQLWQEEQLWREQLWQ;NLGQRFPCQAAAR;PVYILLDEMNAQHFL;RSRARKPRGRRRAGK 7 8.7 0.98665 -0.41039 0 9.94461 10.3852 10.5722 7.1921 0 0 0 0 10.2475 5.12102 0 5.96401 0 10.3731 A0A8C0PJC3 A0A8C0PJC3_CANLF Single-strand-selective monofunctional uracil-DNA glycosylase 1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] DNA binding [GO:0003677]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065] CLRSLAEGFL;PLHEPAGA;VPFGEVNVVPDW 3 19 1.003 -1.9484 0 0 5.89968 8.44344 0 0 0 0 0 0 9.18026 0 0 0 0 A0A8C0PJF8 A0A8C0PJF8_CANLF SET domain containing 4 SETD4 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell proliferation in bone marrow [GO:0071863] cytosol [GO:0005829]; nucleus [GO:0005634] histone H3K4 methyltransferase activity [GO:0042800]; histone H4K20 methyltransferase activity [GO:0042799] LPQAYTCPVCL;QQQGQALLFPAATG;SILKDHDFIENLTFGWD 3 7.8 0.98492 -0.43761 0 0 0 0 0 0 0 8.66117 0 9.58705 0 9.36416 0 10.6682 9.29186 A0A8C0PJG7 A0A8C0PJG7_CANLF Elongator complex protein 6 (Protein TMEM103) ELP6 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] elongator holoenzyme complex [GO:0033588] NIVGQKLGVSLTA;PCSEVHTWEADA;PCSEVHTWEADAG;VLLSLGMGAVAV 4 13.6 1.001 -0.92597 0 9.07612 0 0 0 0 0 0 9.15954 0 9.80924 0 0 10.5667 0 A0A8C0PJI2 A0A8C0PJI2_CANLF TIR domain-containing adapter molecule 1 (TICAM-1) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; response to exogenous dsRNA [GO:0043330]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrion [GO:0005739] EETGQLPTGGDMASPSLE;RDDHRLAELQ;VILHAAADEHIAL 3 6.1 0.96532 0.048639 0 0 0 9.6908 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PJL5 A0A8C0PJL5_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GCAAAAKG;KVRTSWLRDMKALIR 2 4.2 0.98973 -0.26592 0 0 0 0 0 0 0 9.72247 0 0 0 0 0 11.468 0 A0A8C0PJM2 A0A8C0PJM2_CANLF 60S ribosomal protein L32-like LOC100686899 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] AILRPLVKPKII;IIKKRTKKFI;ILRPLVKPKIIKKRTKK;PKIIKKRTKKFIQHQ 4 17.4 0.9922 -0.27851 0 0 0 0 0 0 0 0 0 0 5.38322 0 0 0 0 A0A8C0PJM5 A0A8C0PJM5_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] DSFWTYFSLMQEFFWE;FSPGYAFEKHSGGLPLPPSYVP;LFADQADNI;VQSSGENGIV 4 10.8 0.93648 0.097179 0 0 0 0 0 0 0 0 0 8.03892 0 0 8.12133 0 0 A0A8C0PJN1 A0A8C0PJN1_CANLF Importin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytosol [GO:0005829]; nuclear envelope [GO:0005635] small GTPase binding [GO:0031267] ALLTVQNRDAAWYQLL;EVLPKMMAFCYQILTD;FINQWMNDTDCFLGH;IILQCKGKGIDQ;LDLDNSVDE;LLKKSLFKDQM;QSNNGRGEDEEEEDDDWDEEV;SVLLQKQILKIFYALVQY 8 11.4 1.0038 -1.0592 0 0 0 0 9.12428 0 9.49341 0 0 0 5.58361 9.73993 6.3008 0 9.3751 A0A8C0PJR8 A0A8C0PJR8_CANLF Coiled-coil domain containing 30 CCDC30 Canis lupus familiaris (Dog) (Canis familiaris) NEAKTKQQYQEE;SPAPPGLA;TSQQQSRIQ;VGFLKRII 4 4.9 1.0023 -1.8751 0 0 0 0 9.30417 0 0 0 0 0 0 0 0 0 12.252 A0A8C0PJT7 A0A8C0PJT7_CANLF Signal induced proliferation associated 1 like 1 SIPA1L1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] ESQKNFKFHALSSPQ;GGGKGSGF;HYDVQSILFDLNEA;HYSSHSSSNTLSSNASS;KPEETKENGSPYNYR;LVLHLDRVKRYIVEHVDLGAYY;NSVGFMDTRKRHQSDGNEIAH;NTPIDPSGKF;SIADQLEPT;STPSWQRSED;VESLINSEDI;WNYFGADENLGPVAVSIRREKPEET;YEIMFHVSTMLPYTPN 13 10.5 1.0013 -2.7037 0 5.74825 0 11.4831 7.7322 0 5.76959 0 0 0 9.47352 6.03078 0 10.1546 12.0968 A0A8C0PJV9 A0A8C0PJV9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WMQVSQIKQNPQFL 1 12.7 0.98413 -0.24778 0 0 0 0 0 0 10.3013 0 0 0 0 0 0 0 0 A0A8C0PJW8 A0A8C0PJW8_CANLF aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) ALDH1A1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AKLECGGGPWGNKGFFIQ;IKEAAGKSNLKRVTLELGGKSPFIV 2 9.2 0.99113 -0.13761 0 0 0 12.2797 0 0 0 0 6.84336 0 0 0 0 0 0 A0A8C0PJX1 A0A8C0PJX1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;TKAKETKSKMNYWDFIKIRSF 4 5.8 0.97647 0.047759 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7773 A0A8C0PJZ7 A0A8C0PJZ7_CANLF G1/S-specific cyclin-D2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] SYFKCVQKDIQP 1 4.6 0.9916 -0.20596 0 0 0 0 0 0 0 9.65827 0 0 0 0 0 0 0 A0A8C0PK35 A0A8C0PK35_CANLF Steroid 11-beta-monooxygenase CYP11B2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" GSDVVLQN;LDPWLAYRQHRGHKCGVFLLNGP 2 7.1 0.28125 0.67267 0 0 0 0 0 0 0 9.26343 10.1001 0 0 0 0 8.57387 5.78283 A0A8C0PK40 A0A8C0PK40_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] DEADYYCQSVDPTLGAHTVL;SVLTQPTSVSG;SVLTQPTSVSGSL;SVLTQPTSVSGSLG 4 26 0 3.317 10.38 11.3093 11.3794 10.4887 8.75502 0 0 0 0 10.4736 10.3441 10.9499 0 10.2169 9.89004 A0A8C0PK63 A0A8C0PK63_CANLF Dynein regulatory complex protein 10 (IQ domain-containing protein D) Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EEMNFCENSYPT;ISRRNRRNQEI;MKNRDAEVEKENF 3 7.7 1.0014 -0.69938 0 0 0 9.79292 0 0 0 0 0 0 0 0 0 9.7945 0 A0A8C0PK64 A0A8C0PK64_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHB4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] CRIGYFRARTDFRGAPCTT;GVVLVLVVIVIA;HVYATLRFTML;KPLSGEGSCQPCPANSH;PVSDIRVT;QLALIAGTAVVGVVLVLVVIVIAVL;RGPLRLAQP;SSVRFLKTSE 8 9.4 1.0028 -0.8698 8.68884 6.644 0 0 0 10.3447 0 8.11936 7.6851 0 0 0 10.4459 0 7.64249 A0A8C0PK96 A0A8C0PK96_CANLF Transmembrane channel-like protein TMC1 Canis lupus familiaris (Dog) (Canis familiaris) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; vestibular reflex [GO:0060005] plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] CNYCWCWDLEYGY;EDDTEESSSEEEEEEE;GPCWETMVGQEF;RFCNYCWCWDLEYGYP;VISEDDPEPE 5 7.1 0.9863 -0.45167 4.75162 0 0 0 0 0 7.57796 0 0 0 0 0 6.5479 0 0 A0A8C0PKA4 A0A8C0PKA4_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleoplasm [GO:0005654] RNA binding [GO:0003723] GAVGTAAQDPAAALGRGGGQSP;GGGGGGGG;GHGGGGGCG 3 13.2 1.0026 -0.75647 0 10.2617 0 0 0 0 0 0 0 0 0 0 7.192 0 0 A0A8C0PKB0 A0A8C0PKB0_CANLF Calcium binding protein 7 CABP7 Canis lupus familiaris (Dog) (Canis familiaris) perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] calcium ion binding [GO:0005509] EKFHGTDFDTVFW 1 6 0.94362 0.059681 0 0 0 0 0 0 5.17564 0 0 0 0 0 0 0 0 A0A8C0PKB3 A0A8C0PKB3_CANLF 2'-5' oligoadenylate synthase (EC 2.7.7.84) OAS3 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; double-stranded RNA binding [GO:0003725] DRPGVLQFR;QERMLSLPPFVAQG;VLQFRLASTDLENWM 3 2.9 1.0013 -0.64609 0 0 0 0 9.94295 7.08768 0 0 0 0 0 0 0 8.78722 0 A0A8C0PKC5 A0A8C0PKC5_CANLF Bone morphotic protein 7 BMP7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] growth factor activity [GO:0008083] AERSRPGRGHVWRGRSGARLQ;IDGHKYLKESSKGVERNT;LVEHDKEFFYPR;VLRVKNILVLVKY 4 10.2 0.99581 -0.085069 4.73129 0 10.137 0 0 0 0 0 0 0 0 8.90782 0 3.98941 0 A0A8C0PKD2 A0A8C0PKD2_CANLF ADAM metallopeptidase domain 20 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] KMAMPSQHFSPELVI;LVIEEGEECDCG;NDTTCWGT;QISECDLPEWCNGTF;SLVLLVIVEKH;VFEEDRLYLFALTVTHELGHNMG;VIEEGEECDCGTTD 7 12.3 1.0025 -1.173 6.06736 6.85748 0 0 6.34289 0 0 6.87073 11.4896 0 0 0 0 2.48664 10.4569 A0A8C0PKE4 A0A8C0PKE4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVKQIMEEAVTRKFVHEDSSHIISF 1 40.3 0.99071 -0.29766 0 0 0 0 8.43346 0 0 0 0 0 0 0 0 0 0 A0A8C0PKG8 A0A8C0PKG8_CANLF Fibronectin type-III domain-containing protein FNDC3A Canis lupus familiaris (Dog) (Canis familiaris) AKNEYGTSGFSE;ESTRTRRALSDEQCAAC;MSSPPSSPQN;QIGTEIEEKDEETKAFEALL;SGKGKGGA;VGPYSTTVLFISQR;YGDVDAHSTHGRSN 7 8.1 1.0026 -1.777 0 0 0 10.0641 0 0 9.83404 10.0307 0 8.55945 0 0 8.5575 0 0 A0A8C0PKH8 A0A8C0PKH8_CANLF Perilipin PLIN5 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] DLEALVDEVVGGPDPRWAHLDWPAQ;EVVGGPDPRWAHLDWP;KDRHPLLGSACRLAEHCV;VDELLELV 4 11.2 1.0023 -0.97131 0 0 0 9.08515 0 0 10.5029 0 8.70359 0 0 8.00163 0 0 0 A0A8C0PKI5 A0A8C0PKI5_CANLF Oxysterol-binding protein OSBPL5 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] ALELALRCSSL;ARAPALGV;HQGPGPERRL;ITQPLPSSYLIFRAASE;RRTTYVEQVHEE;TMELGGRVTIE 6 8.1 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 7.91205 0 0 A0A8C0PKJ5 A0A8C0PKJ5_CANLF Trehalase (EC 3.2.1.28) (Alpha-trehalose glucohydrolase) TREH Canis lupus familiaris (Dog) (Canis familiaris) trehalose metabolic process [GO:0005991] "alpha,alpha-trehalase activity [GO:0004555]" ALLLSLLLGLLPQ;KYRNLWQQRLA;RFRELAATH;VLSHPEQFSLIYAA 4 8.5 0.94142 0.059873 0 0 0 0 0 0 0 0 0 0 0 0 0 9.48178 0 A0A8C0PKL6 A0A8C0PKL6_CANLF Ig-like domain-containing protein VSTM2L Canis lupus familiaris (Dog) (Canis familiaris) ALFTETPHDM 1 4.9 0.99949 -0.61146 0 8.80781 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PKL7 A0A8C0PKL7_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GVVSWSLSCNRHR;LLCAAVCEGCLLLDE;NDMLCVSSEWGMDSCQDNSGSSL;SIYTSTSQFTHWIKRQISDMRFI 4 22.4 0.98422 -0.24265 0 0 0 0 0 0 0 0 0 0 0 9.61296 0 0 0 A0A8C0PKM1 A0A8C0PKM1_CANLF Hermansky-Pudlak syndrome 5 protein homolog HPS5 Canis lupus familiaris (Dog) (Canis familiaris) BLOC-2 complex [GO:0031084]; cytosol [GO:0005829] HVLAEFESLDPL;LDPLLSAL;LNLIQKEGWKHRLF;LQDPLVLFEPESLRMVL;QDVAVYKNELFCLHLNG;TFETDKNETFLP;VLFEPESLRMVLQEWL;VTQLCHHHPAQFL 8 9.1 1.0026 -1.1262 0 11.9383 9.61202 0 8.87274 0 0 11.3376 0 0 0 0 0 0 9.62044 A0A8C0PKQ0 A0A8C0PKQ0_CANLF FA complementation group F Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] AAEPAHVSWAEL;PAAALQARLARLARRRGAVRLLLR;RGSGSGSGSARGRMESLLQ 3 11.4 0.99292 -0.2872 0 0 11.2142 0 0 0 0 0 0 0 0 0 10.3687 11.1673 0 A0A8C0PKQ7 A0A8C0PKQ7_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] LALDRSNTQLGGGTGA;PWSVPAWGLIVRSVLGGRFKKEI 2 4.9 0.97845 0.04627 0 0 0 4.18753 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PKR2 A0A8C0PKR2_CANLF Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zona pellucida protein B) ZP4 Canis lupus familiaris (Dog) (Canis familiaris) single fertilization [GO:0007338] egg coat [GO:0035805]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] EGPGSSMV;SCGTTRRITGD;VTKTQLLRCPMDP 3 5.9 1.003 -1.7277 0 0 0 0 0 0 0 0 0 0 7.2891 0 0 0 0 A0A8C0PKR3 A0A8C0PKR3_CANLF PKD domain-containing protein KLHL7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NEELYPVWKKGDSRWKNSWKGGH;VCDPVGEDMGHECLL 2 6.4 0.94013 0.10017 0 9.58446 0 0 0 0 0 0 0 0 0 0 7.35253 0 0 A0A8C0PKS6 A0A8C0PKS6_CANLF DUF4708 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FYKAGKLNAYIEKCG;QDILVSPVPGILSQIWVVM;VGVNDHKLIISKTSHRSKR 3 8.2 0.86233 0.15312 0 0 0 4.90641 0 10.0448 0 0 0 0 0 5.43085 0 0 0 A0A8C0PKS7 A0A8C0PKS7_CANLF 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC 2.3.1.51) (Abhydrolase domain-containing protein 5) Canis lupus familiaris (Dog) (Canis familiaris) lipid homeostasis [GO:0055088]; negative regulation of sequestering of triglyceride [GO:0010891]; phosphatidic acid biosynthetic process [GO:0006654]; positive regulation of triglyceride catabolic process [GO:0010898] lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739] carboxylic ester hydrolase activity [GO:0052689]; lysophosphatidic acid acyltransferase activity [GO:0042171] DLLLFLLVSILLFLLLLIR;GGFLAAAY;LDLLLFLLVSILLFLLLLIRTNIF;LLVSILLFLLLLIR;TYKKEPVLIS 5 7.1 1.0028 -1.6614 0 0 0 0 0 3.13222 0 0 0 6.37601 2.68174 6.15162 0 2.66234 0 A0A8C0PKT1 A0A8C0PKT1_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] ASGHDDSGTPDA;DEMEEEEGEEAE;EEEEEDEMEEE;NLEQKGQEPCLPVT;PEDDLPTDQTV;PLQEQLSINQIKTEPVDYEFKPIVV;VEPLDLSLPKQQGE 7 8.1 1.0018 -0.67095 12.3982 9.9691 0 0 8.75114 0 7.46989 10.6519 0 0 7.09244 0 0 0 0 A0A8C0PKU1 A0A8C0PKU1_CANLF aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) ALDH7A1 Canis lupus familiaris (Dog) (Canis familiaris) aldehyde dehydrogenase (NAD+) activity [GO:0004029] IPTSGAEIGGAFGAAHRET;LAAVEDAKKEGGTVV;TAMAKDERVN 3 8.7 0.99563 -0.56894 0 7.12619 0 0 0 0 7.54982 0 0 0 10.127 9.32906 0 0 0 A0A8C0PKV3 A0A8C0PKV3_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LPFTFFLAI;PALMSTWLCGCLAAGA;YFFLCHFSL 3 10.2 1.0019 -0.68429 0 0 12.5914 0 0 10.7055 0 0 0 0 0 0 0 0 0 A0A8C0PKV6 A0A8C0PKV6_CANLF "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.7)" ACADM Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] HPGSNARG;MGQRCSDTRGIVFEDVK;PGAGRGQA;TEPGAGSD;VEADTPGVQ;VFEDVKVPKE 6 9.2 0.99747 -3.8441 0 10.2726 0 8.01954 6.56151 8.26922 9.83548 9.65132 0 7.32337 9.51619 0 0 9.86939 9.97785 A0A8C0PKX1 A0A8C0PKX1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GDQPDEEEADDFLDYPTD;VGLPVVFIL 2 9.4 1.0028 -0.7559 0 3.80023 0 0 0 0 0 0 0 0 0 8.63099 0 0 0 A0A8C0PKX3 A0A8C0PKX3_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKZ Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] DLPTPTSPLPTSPCSPTL;ESATYGEHIW;MEPRDGSPEARSS;NIREPTFVRHHW 4 5.7 0.98608 -0.2583 0 0 0 0 9.74064 9.55524 0 0 0 0 0 0 0 0 0 A0A8C0PKX6 A0A8C0PKX6_CANLF IPT/TIG domain-containing protein EBF3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LAVNVSETSQANDQVKQKS 1 3.2 0.95017 0.049923 0 0 0 0 0 0 0 0 0 0 0 0 7.18031 0 0 A0A8C0PKX8 A0A8C0PKX8_CANLF Solute carrier family 13 member 5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] solute:sodium symporter activity [GO:0015370] EDGKTKYATDATVAAF;GFMGVAFL;GVFCAFLAINT;KFKSFVILFITPLLLLPLVILM;LPCTLSASFAFMLPV;PLLLLPLVI;VGAKPAQL 7 15.2 1.0029 -2.5216 0 6.19148 0 0 0 0 0 0 10.2115 0 0 0 9.46555 10.3706 0 A0A8C0PKY7 A0A8C0PKY7_CANLF Solute carrier family 9 member B2 SLC9B2 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; flagellated sperm motility [GO:0030317]; lithium ion transport [GO:0010351]; positive regulation of osteoclast development [GO:2001206]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; sodium ion homeostasis [GO:0055078] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; mitochondrial membrane [GO:0031966]; recycling endosome [GO:0055037]; sperm principal piece [GO:0097228]; synaptic vesicle membrane [GO:0030672] identical protein binding [GO:0042802]; lithium:proton antiporter activity [GO:0010348]; sodium:proton antiporter activity [GO:0015385] AAGSLLGFFIQYF;ALRSIALSVILVRAG;VLGLSVLAVFSSVYFGFPGS 3 8.9 0.99115 -0.19571 0 0 4.60146 0 0 0 10.0239 0 0 0 0 0 0 0 0 A0A8C0PKZ4 A0A8C0PKZ4_CANLF Dedicator of cytokinesis 1 DOCK1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DCREILLPMMTDQLK;EAISEYKSVI;HDLIVYKAE;KAFFTERYLQE;LDHEVEGG;NMSSRFSPRVAGE;PRSMVRSFTMPSSSRPLSVASV;RECDNYTEAAY;SEKIFALAFVKL;SESETFDT;TVNVLNFYKEIEREEMYIRYLYKLC;WSEDVCAAHLTQ 12 8.3 1.0021 -2.5935 0 4.27925 8.98162 0 0 0 9.281 0 10.774 0 9.81498 0 0 9.50038 0 A0A8C0PKZ5 A0A8C0PKZ5_CANLF PC-esterase domain containing 1B PCED1B Canis lupus familiaris (Dog) (Canis familiaris) DGSLIERVI;FYSFSRTGHPWGM;HLQASEVQQLLH;LLHFSAPELPSQ;LSQLLLAHL;NGVQYREVRQFCDAHHLVRFY;WGGRPRPSRRRAHSRPQP 7 16.1 1.0013 -0.94025 0 7.3984 0 10.586 6.84725 0 0 10.5706 0 0 0 0 0 10.0719 0 A0A8C0PL03 A0A8C0PL03_CANLF Septin-2 LOC119868838 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157] ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; midbody [GO:0030496]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940]; spindle [GO:0005819]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ERLKKRILDEIEEHN;EVTQDLHYENFRS;GGGGGGGG 3 7.6 0.9842 -0.2443 0 0 0 0 8.22752 0 5.59186 0 0 0 0 0 0 0 6.08004 A0A8C0PL11 A0A8C0PL11_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" VLEGMVETVCEDL 1 1.7 0.98462 -0.23951 0 0 0 0 0 0 9.81933 0 0 0 0 0 0 0 0 A0A8C0PL33 A0A8C0PL33_CANLF Chromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] membrane [GO:0016020]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064] YKIWVFVFWFIS 1 5.5 0.94409 0.05044 0 7.46132 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PL40 A0A8C0PL40_CANLF Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" EIYIQQACTLPITL;IDAFVRAKADSAYHPSCTCK;PDAPSPGRPPPPPPGSC 3 5.2 0.85766 0.16909 8.05028 0 0 0 0 0 10.1812 0 0 0 0 4.0906 0 0 0 A0A8C0PL53 A0A8C0PL53_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVGSYVDS;HLKSDEELPP;LMKHRKGKPPNVSVFEPKANAEDP;LPPTIPGV;LPPTIPGVGSYVDSPS;QSCDPDSALGPS;SGYDDDADENSMEDDAE;VLQQHIRMHMGGQIPNTP 8 10 1.0016 -2.6285 0 0 0 2.7392 0 9.34638 0 8.2306 0 0 0 9.02641 10.2639 10.3971 0 A0A8C0PL55 A0A8C0PL55_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MPPLVNFNKMMLQ 1 6.8 0.99089 -0.26952 0 0 0 0 0 0 0 0 0 0 0 0 8.29522 0 0 A0A8C0PL66 A0A8C0PL66_CANLF 2-oxoglutarate and iron dependent oxygenase domain containing 2 OGFOD2 Canis lupus familiaris (Dog) (Canis familiaris) "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" EELEHFEQSD;GGALYFGG;SSYHPARPDLYNTL 3 11.1 1.0043 -1.0888 0 0 0 0 0 0 0 0 0 0 0 0 9.75874 0 0 A0A8C0PL70 A0A8C0PL70_CANLF CBF1-interacting co-repressor CIR N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPLQEIQKH;RTEFLRKKARHQHSLPE 2 10 0.98959 -0.51689 0 0 0 0 0 10.0101 0 0 0 0 0 0 0 8.44269 0 A0A8C0PLA7 A0A8C0PLA7_CANLF Oxidoreductase-like domain-containing protein OXLD1 Canis lupus familiaris (Dog) (Canis familiaris) ELQLPTNCCMSGCPNCV 1 11.6 0.97853 0.046227 0 0 3.73574 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PLB4 A0A8C0PLB4_CANLF SID1 transmembrane family member 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DGGHTCQSDTDSS;DLWFWVIF;ENIYSFNYTSQPG;FNYTSQPGQ;LSTENIYSFNYT;LVAFVHYISIASLCF;SQPQYFLYKFP 7 8.1 1.0032 -2.3195 10.2408 7.31687 2.75916 0 7.42358 0 11.707 5.13348 0 0 5.33718 0 0 6.04037 10.0513 A0A8C0PLB5 A0A8C0PLB5_CANLF TNFR-Cys domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of T cell differentiation [GO:0045582] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] LLIPHPSPARGPHLQPT 1 7.4 0.97875 0.046227 0 0 0 0 5.04715 0 0 0 0 0 0 0 0 0 0 A0A8C0PLB7 A0A8C0PLB7_CANLF DUF4795 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) APGPWVPSSPTTSL;DLASVARDWHHP;ETRPAALESQ;GQPGLVQPAMDQRGL;IHFGGSVKASSQMIRELLQAQC;SLDPKQIYTVDQ;SMSQFRKESDRRRMREPQLHSLA;STLLSMSMAP;TDQQRLELPSTGQPGM;VGPGLPGHRSIRPYTIFEL;YHSLEKLEKEKANREHLEME 11 10 0.99087 -0.19557 0 9.13178 0 0 0 0 0 0 0 0 4.60431 0 0 0 0 A0A8C0PLC4 A0A8C0PLC4_CANLF DDHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] DSDESSDDEYFDA;PDALTAFPTV;SIPVPALTWQDGPRPSP;YGPLDMVTLTGEKVDVHIMMQ 4 4.6 0.99713 -0.11033 9.78606 10.2251 0 0 0 0 0 9.84645 0 0 0 0 0 0 0 A0A8C0PLC6 A0A8C0PLC6_CANLF "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2" Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" ATFEVIENEELERP;KEEERNDWISILLNALK;KLLEETNKKWCVLEGGFLSY;MEAEELTNDILAIK;NSGSGTNG;RFCLQMQEVQEDRM;SEVNVDIRDFLMSIN 7 5.9 1.0046 -1.048 3.52331 6.49965 0 9.14881 0 3.03268 12.3831 0 0 0 0 0 0 9.33903 0 A0A8C0PLD3 A0A8C0PLD3_CANLF Protein CUSTOS C26H12orf43 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] AKKKKKKLKKKAKKE;DQASLGTKKKRRKKKAKK;GEAKKKKKKLKKKA;GEAKKKKKKLKKKAKK;GGEAKKKKKKLKKK;GTKKKRRKKKAKKAK;IKVGGEAKKKKKKLKKKAKK;KKKKKKLKKKAKKEAS;KKKRRKKKAKKAK;KVGGEAKKKKKKLKKKA;KVGGEAKKKKKKLKKKAKK;KVGGEAKKKKKKLKKKAKKE;LGTKKKRRKKKAKKAK;TKSAMAAP;VGGEAKKKKKKLKKKAKKE 15 19 1.003 -1.3386 0 5.79119 5.53123 0 11.9889 10.2251 5.08967 0 0 7.55942 5.284 0 8.30697 0 5.70407 A0A8C0PLD5 A0A8C0PLD5_CANLF BTB domain-containing protein KLHL18 Canis lupus familiaris (Dog) (Canis familiaris) DVSMSEEFLALPL;GVMEEIRRQGK;IFNSVEHYNHHT;LIYAVGGLNSAGD;SAAGVTVFEGRIYVSG;SELPSRGYGVMEEIRRQGKLC;SGFLSIAEVYSSVA;VRSMNSKRSAMGT;WTFMAPMACHEGGVG 9 20.4 1.0036 -1.0594 0 0 0 0 0 0 8.30282 0 10.0153 0 0 0 0 8.40467 0 A0A8C0PLE1 A0A8C0PLE1_CANLF Bicarbonate transporter-like transmembrane domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoatomic anion transport [GO:0006820] plasma membrane [GO:0005886] solute:inorganic anion antiporter activity [GO:0005452] ITTTLFLYFACLLPTI;LFERVALLL;SLSASMPCYLKCDMDDASETR 3 5.5 1.0038 -1.0434 0 8.02153 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PLG6 A0A8C0PLG6_CANLF CUB and Sushi multiple domains 3 CSMD3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSTTHETS;LLCEKNHWWSHPLP;NEGILLSPNYPLNYENNH;NFHTFHLEDHHDYLL;NWAMDGFVSAEPDGA;VGDVVSFQCDQGYS;VIYSCMEG;VLICQPNGQ;VLQTEPIYDFI;VLSYHAYQLRVCQ;VQFNFHTFHL;VTAVTIHRLSEE;YEYKTKVVFSC 13 4.1 0.99671 -4.2171 10.7399 6.82807 10.0111 0 0 8.59305 0 7.9295 0 0 0 0 8.69397 7.93522 9.1062 A0A8C0PLG8 A0A8C0PLG8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EPGHFAQMFRCRGLWP;SDPREPGHFAQMFRCRGLWPTL 2 4.8 0.92666 0.096116 0 7.4048 0 0 0 0 0 0 0 0 0 0 0 9.01002 9.96751 A0A8C0PLH0 A0A8C0PLH0_CANLF Solute carrier family 5 member 12 SLC5A12 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] AGNWEEMWTHTA;GVQHDGGTEQLLAGNW;GVVQAALSIHG;SFMSAVTVLGAPSEVYRFGAS 4 9.5 0.98776 -0.37753 8.39951 0 0 0 0 0 0 0 0 6.94907 0 0 0 0 0 A0A8C0PLH5 A0A8C0PLH5_CANLF Ras and Rab interactor 2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AAAEPLWARPTLS;AELHSRPQ;EAMLRDFHMADGSW;EDCEEESDQE;EKKVMLLLR;YLSQSSELDPPIESLIPE 6 6.4 0.94333 0.059672 0 0 0 0 0 0 0 6.90123 0 0 0 0 0 0 0 A0A8C0PLH7 A0A8C0PLH7_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] WNAMGEIGFDQFYMLV 1 8.2 0.99362 -0.070084 0 0 0 0 0 0 0 0 0 0 0 0 0 14.6735 0 A0A8C0PLI7 A0A8C0PLI7_CANLF SPARC like 1 SPARCL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] calcium ion binding [GO:0005509] GANDDGDD;NKDKHITLEEWG;TDNQTYAS 3 5.3 1.003 -2.1583 0 0 0 7.072 0 0 0 0 0 0 0 0 5.08304 6.72055 0 A0A8C0PLJ8 A0A8C0PLJ8_CANLF Uncharacterized protein ZCCHC17 Canis lupus familiaris (Dog) (Canis familiaris) RNA stabilization [GO:0043489] RNA binding [GO:0003723] AAKKKKKK;AAKKKKKKKKHKKKH;AKKKKKKKKHKKK;KAAKKKKKKKK;KDSKAAKKKKKKKKHKKK;KKKKKKKK;KKKKKKKKHKKKHKERS;TSKDSKAAKKKKKKKKHKKKH;TSKDSKAAKKKKKKKKHKKKHK 9 11.5 0.97986 0.046227 0 0 0 0 6.66121 0 0 0 0 0 0 0 0 0 0 A0A8C0PLL4 A0A8C0PLL4_CANLF Transmembrane protease serine (EC 3.4.21.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] DISVAELSSPV;DPESVEIKSCGTRRS;HYVRYNQRKTYNYYGTLSFTSNKL;INSTWLVSAAH 4 14.9 0.95044 0.053907 0 0 0 0 8.82553 0 0 0 0 0 0 0 0 0 0 A0A8C0PLL9 A0A8C0PLL9_CANLF C2H2-type domain-containing protein BCL11B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AGGCGDAG;DLLDGGLSGRSGTASG;GGGFAPGA;GGGGGGDAGDDD;GGGGGGGD;GGGGGGGG;GVGGVGVGVGGVGG;HEPEEDDEEEEEEEEELLLENESRP;KDLELPPAALIPSENVY;LVFIEHKKKQC;PGGGGGGG;PPMPPGGT;VGGVGVGVGGVGGVGVGVAGGV 13 16.6 0.99889 -2.9762 0 0 11.7672 7.96751 6.07498 7.47143 0 0 0 12.0989 0 0 7.6605 9.83189 0 A0A8C0PLM9 A0A8C0PLM9_CANLF UfSP1/2/DUB catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-like protein peptidase activity [GO:0019783] LYSHFAGG 1 4.8 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 6.22381 0 0 A0A8C0PLN3 A0A8C0PLN3_CANLF F5/8 type C domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WLSKYQDSSQWLQI 1 8.2 0.93693 0.060957 0 0 0 0 0 0 0 7.89972 0 0 0 0 0 0 0 A0A8C0PLP3 A0A8C0PLP3_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PALDLAPD;WIAQRAFVALYV 2 4.7 0.98799 -0.47204 0 0 9.44822 0 0 0 9.74315 0 0 0 0 0 0 0 0 A0A8C0PLQ8 A0A8C0PLQ8_CANLF Erythroblast membrane associated protein (Scianna blood group) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFPTWDTYPRSLKNK;VTATPANGHWLVRQSS 2 5 0.94786 0.054534 0 0 0 6.72438 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PLR6 A0A8C0PLR6_CANLF DCD domain-containing protein NCMAP Canis lupus familiaris (Dog) (Canis familiaris) peripheral nervous system myelin formation [GO:0032290]; regulation of myelination [GO:0031641] paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; Schmidt-Lanterman incisure [GO:0043220] structural constituent of myelin sheath [GO:0019911] VAAIVVVVIIIFAVVLILL;VVLILLKMYNRK 2 24.8 0.9912 -0.27299 0 0 0 0 0 0 0 4.89826 0 0 0 0 0 0 0 A0A8C0PLT4 A0A8C0PLT4_CANLF Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; DNA repair [GO:0006281]; DNA replication [GO:0006260] chromosome [GO:0005694] catalytic activity [GO:0003824]; GTP binding [GO:0005525] IVDVSEFLPERFAEQLI 1 3 0.99229 -0.13927 0 0 0 0 0 0 0 11.7052 0 0 0 0 0 0 0 A0A8C0PLT5 A0A8C0PLT5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) urogenital system development [GO:0001655] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PYICCECGKSFS;VISAGRGQSGLHSE 2 9 0.99142 -0.54832 0 0 0 0 0 0 0 0 0 8.71987 0 0 0 0 0 A0A8C0PLU1 A0A8C0PLU1_CANLF Oxidation resistance protein 1 OXR1 Canis lupus familiaris (Dog) (Canis familiaris) EYWFAVPQERTDHLYAF;GGGGEFAL;LAFGGGGGEFALWL;PPAGHCQPPVGLRGWRRSP;QRDKKHEYWFAVPQERTDHL;VHGEERAPPAGHC;VHGEERAPPAGHCQ 7 7.2 0.99087 -0.5141 8.02536 8.59653 0 0 11.0532 0 0 11.584 9.98556 0 0 0 0 4.80214 0 A0A8C0PLU9 A0A8C0PLU9_CANLF TRAF-interacting protein with FHA domain-containing protein A Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] IEKEDGESLE;PGQLQNGIFQ 2 10.8 1.0028 -0.77928 0 0 0 0 0 0 0 0 0 12.4282 0 0 0 9.39767 0 A0A8C0PLW1 A0A8C0PLW1_CANLF Prothymosin alpha Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAEDDEDDDVDP;EEEDGDGDEEAEAAAG;EEEEEEEGDGEEEDGDGDEEAE;EVDEEEEEEEEGDGEEEDGDG;NEVDEEEEEEEEGDGEEED 5 26.7 0.93362 0.096576 0 0 0 0 0 5.20531 0 0 0 10.2484 0 0 0 0 0 A0A8C0PLW4 A0A8C0PLW4_CANLF Maestro heat like repeat family member 7 MROH7 Canis lupus familiaris (Dog) (Canis familiaris) DKDSKMALVENVITL;LHSSTHGP;SPETGQFPLG;VGRVRRIYPQLLLAL;VSPETGQFPLG 5 3.7 1.002 -0.66966 0 0 11.6051 0 0 6.06549 0 0 0 0 0 11.8046 11.8683 12.6415 0 A0A8C0PLY9 A0A8C0PLY9_CANLF Osteoclast associated Ig-like receptor Canis lupus familiaris (Dog) (Canis familiaris) DWHSQSRTQAASGP;ELAEFFLE;LVVFDWHSQSRTQAASG 3 9.5 1.0029 -0.98369 0 0 0 0 0 0 0 9.69836 0 9.31771 0 0 0 8.95376 0 A0A8C0PM01 A0A8C0PM01_CANLF Frizzled class receptor 8 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; non-canonical Wnt signaling pathway [GO:0035567] plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] AGCAPLMRQYG;CQEITVPLCKGI;GGGAGGAA;LQPDQARRPDYAVFMLKYFMCL;RGGGGGGK 5 9 1.0034 -1.5588 0 0 0 0 0 0 0 0 11.3326 0 0 0 9.87243 0 9.47037 A0A8C0PM07 A0A8C0PM07_CANLF BRCA2 and CDKN1A interacting protein Canis lupus familiaris (Dog) (Canis familiaris) spindle pole [GO:0000922] AEEEEEDGVEDED;DEDEGESDEDEDGD;EDEDEDEGESDEDEDGDDESVDEEV;EEEEEDGV;GVEDEDEDEGESDE;GVEDEDEDEGESDEDEDGDD;MKMASRPKWHAVGSGAPQ 7 22.7 0.99507 -0.12825 0 0 0 7.00776 6.77716 0 8.8783 0 0 0 5.97299 0 6.75836 0 0 A0A8C0PM20 A0A8C0PM20_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] DLAVRFSEEEWQLLG;GGGAAVNP;LMPGPQNPEVSP;SGAVSLDGERGSPDV;SPVLPSGP 5 5 1.0022 -1.3706 9.60726 0 0 0 10.8521 0 0 11.1207 0 11.2252 11.0875 0 8.92452 0 0 A0A8C0PM27 A0A8C0PM27_CANLF Transmembrane protein 176A TMEM176A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SGCSLLRSHFPGATF;VLLLLASLVPLCLFC 2 12.4 0.99368 -0.18835 0 0 0 0 0 0 5.66502 0 0 0 0 0 0 9.48854 0 A0A8C0PM37 A0A8C0PM37_CANLF RAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitochondrial mRNA stability [GO:0044528] mitochondrion [GO:0005739] KSRKHTQGETESETEP;RLGADRLACMQAPQ;TDARMAATL;VGVSLTDDLMNQ;YFPFELINF 5 7.4 1.0021 -1.307 0 0 7.31379 0 8.62961 0 0 0 0 0 0 0 4.08941 0 0 A0A8C0PM39 A0A8C0PM39_CANLF Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] cytokine activity [GO:0005125] APASRERPG;TSPLGRILKGSCQDPSLIR 2 5.7 0.95014 0.049713 0 0 0 0 0 8.96878 0 0 0 0 0 0 0 7.18656 0 A0A8C0PM46 A0A8C0PM46_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCECDSGAGG;PEGPPAADTQLQGSLCALS;SSSFGSFA 3 8.9 1.0029 -1.3791 0 0 0 0 0 0 0 0 0 0 0 8.34239 0 0 9.36291 A0A8C0PM54 A0A8C0PM54_CANLF "Papilin, proteoglycan like sulfated glycoprotein" PAPLN Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] ADRRPCSTHPCPQTKRTSYLHRPR;CCPDGVSAAE;CQQSRYGCCPDGV;DMGGLGAI;GTSLDPHARWQ;PEVPSMQDVHTSPRDPW;VGCDHNLDSSKEEDK 7 7.4 0.97395 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 6.16912 0 0 A0A8C0PM55 A0A8C0PM55_CANLF H(+)-transporting two-sector ATPase (EC 7.1.2.2) ATP6V1A Canis lupus familiaris (Dog) (Canis familiaris) ATP metabolic process [GO:0046034] "clathrin-coated vesicle membrane [GO:0030665]; lysosomal membrane [GO:0005765]; proton-transporting V-type ATPase, V1 domain [GO:0033180]" "ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" GEAKIKADYAQ;VGMLSNMIAFYDMARR 2 4.6 0.98802 -0.49452 0 8.5789 0 0 0 0 0 11.3686 0 0 0 0 0 0 0 A0A8C0PM70 A0A8C0PM70_CANLF 4-hydroxyphenylpyruvate dioxygenase HPD Canis lupus familiaris (Dog) (Canis familiaris) aromatic amino acid metabolic process [GO:0009072] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872] IVREPWIEEDKFGKVK;TTHTLVEKINYT 2 7.1 0.98661 -0.45767 0 0 0 0 0 14.3704 10.485 10.6485 10.5423 0 3.59467 0 0 0 0 A0A8C0PM72 A0A8C0PM72_CANLF F-box and WD repeat domain containing 12 CDK20 Canis lupus familiaris (Dog) (Canis familiaris) GWAGWVGGGSAAGWR;TEIWSSPLQ;VYVWNKEN 3 5.1 0.9898 -0.20057 0 0 0 0 0 0 10.3583 0 0 0 0 0 0 0 0 A0A8C0PM77 A0A8C0PM77_CANLF Myosin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AGDAERSQAASALSRART;ATFEELCHNYAHERL;EVSGPAGRGPGANQ;FSSCESLFESGQNVG;KDKESVLPSKAEK;MRIEYLEQ;PAHLGSLAK;PATDPGGEKKGGTPGTPRGPQ;PLGLEDWPTLPIYQTTG;RFAMVMSLDFNATGRVTAAQLQ;SLATDTMRSPSR;SPLCLRRQKYYH;SPQRSRIHFETE;VLESERAERQRAFREV 14 8.3 0.9869 -0.23149 0 0 0 0 0 0 0 9.54282 0 0 0 0 0 0 0 A0A8C0PMB6 A0A8C0PMB6_CANLF Srp40 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] AAIPKKILPKKQVVAKSP;ALKTNGTS;EVAAAIPKKILPKKQVVAK;SSEEEEEEEEQKKPMK;SSSDSSDSDSSEDE;VAKAVPSL 6 10.4 1.0019 -1.408 10.3697 0 0 0 6.88643 3.84579 5.93225 0 0 0 12.836 0 0 0 0 A0A8C0PMD9 A0A8C0PMD9_CANLF "MYB proto-oncogene, transcription factor" MYB Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of miRNA transcription [GO:1902895]; T-helper 2 cell differentiation [GO:0045064] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DIEMCDHDYDGL;EAASCGKME;EDDEDIEMCDH;NHWEGESLNTQL;SDEDDEDIEMCDHD;STTIADHTRPHGDSAPV 6 7 0.99447 -0.56085 0 0 0 0 0 6.56663 0 5.49474 0 10.6923 0 0 0 6.94732 0 A0A8C0PME1 A0A8C0PME1_CANLF Beta-galactosidase (EC 3.2.1.23) GLB1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" DVSNWFALLESLNVRP;GSYFTCDYDYLRFLQ;PLHNENNASQRT;PQPGQYQFSGEQDVEYFIKLAHEL;SMIVSRSYLAGSLELG 5 8.7 0.98774 -0.39997 0 11.7482 0 7.88746 6.81468 5.3717 3.56669 0 10.0771 0 0 0 0 0 11.4317 A0A8C0PME3 A0A8C0PME3_CANLF Centromere protein C Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382] kinetochore [GO:0000776]; nucleus [GO:0005634] centromeric DNA binding [GO:0019237] CLDDEERKKKFMVNL;MDLLRPRDTYEFFIEHDELKVYKTL;QDCFEEKSFANDF;VLFSTPKVGDICIQSPSKEC 4 7.9 0.94674 0.084774 0 0 0 0 0 0 0 9.68863 0 0 0 0 7.76911 0 0 A0A8C0PMF5 A0A8C0PMF5_CANLF Calpain catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] ADGCRSGP;LYTEAVDLCLKTSYETADKTLQ;SPFLERPQPFISPQSC 3 5.7 0.98897 -0.26225 0 10.2694 0 0 0 0 0 10.7776 10.0968 0 0 0 0 0 0 A0A8C0PMH0 A0A8C0PMH0_CANLF Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) MED24 Canis lupus familiaris (Dog) (Canis familiaris) mediator complex [GO:0016592] AAWRSTWPPASLLV;GTALAKLA;GTEELKWTAFTF 3 3.4 1.0034 -1.6091 0 0 0 0 0 0 0 0 0 7.2804 0 0 0 0 12.5562 A0A8C0PMK6 A0A8C0PMK6_CANLF Fibrillar collagen NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AAYDYCEHYSPD;DDMNYNEGFENPDQSP;DLQLCHPD;DMGPQGPRGVQGPPG;DTYYYEYPYYEDT;EAGEPGLP;EDGDKGEIGE;FPPGHCPQCEHCSLTGGSGAQ;GAGKEEDPGIGDYDYM;GGPPGPKG;LLLLLLLL;LLLLLLLLL;LSSPPLLLLLLLL;PDKKSEGARITSWPKEN;PGPVGEQGLPG;PGTMGPTGQVGDPGERGPPGRPGL;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PQCEHCSL;PQSQDPNPDEY;PYYEDTDDPSK;SGAQRPRPPRTHSVEASSWPW;VGALGLKGSEGPP 25 13.3 0.99746 -3.5526 9.58227 9.57295 6.41046 0 7.49313 0 0 12.0221 8.20002 0 10.0422 9.38085 9.01488 9.36278 11.9317 A0A8C0PML1 A0A8C0PML1_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADLAEHQRAH;ECGKAFIRSSKLI;HYADLAEHQRAHA;QYECKECGKAFRHRSD 4 8.5 1.0031 -1.1209 0 0 0 0 0 0 10.1215 0 6.15945 0 0 7.00551 0 0 0 A0A8C0PMM2 A0A8C0PMM2_CANLF Fibroblast growth factor (FGF) Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] AKYSGCHLFIV;PVTVCPPGRSSDF 2 7.5 0.99113 -0.19467 0 0 8.36006 0 7.35729 7.54342 0 0 0 0 0 0 8.4248 0 8.6125 A0A8C0PMN9 A0A8C0PMN9_CANLF Integrator complex subunit 2 INTS2 Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] AADVLCIL;EQLMVVWLSWM;IGLVGQTDGPE;LVAMYFHSNQLSAIIDLVCST 4 4.6 1.0034 -1.549 0 0 0 0 0 0 11.3443 9.74749 0 9.08146 0 11.9614 0 0 9.14929 A0A8C0PMR8 A0A8C0PMR8_CANLF L-Fucosyltransferase (EC 2.4.1.-) FUT1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; fucosylation [GO:0036065]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107] IFAGDGQEGSPGKD;SHMPWRELQLHDWMSEDYAHL;VGINANLSAVQ 3 12.6 0.99323 -0.065086 9.54181 0 0 0 0 0 0 0 15.37 0 0 0 0 6.9888 0 A0A8C0PMS5 A0A8C0PMS5_CANLF VPS35 endosomal protein-sorting factor-like CCP110 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; protein transport [GO:0015031] endosome [GO:0005768] CKCIMEVFIKHQQE;IQFYPSKFVLITDILDTFG;NRIEELNQSL;TQQDYVNRIEELN;VLHNHGAPQGSAGGHLPLTIM 5 6 0.96123 0.04885 0 9.03488 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PMU5 A0A8C0PMU5_CANLF Calponin-homology (CH) domain-containing protein FLNC Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] intracellular non-membrane-bounded organelle [GO:0043232] actin filament binding [GO:0051015] AEIAFEDRKDGSCGV;AGEAATFTVDCSEAGE;DIDFDIIKNDND;DMSGRYTIT;EGPHTVHVAF;EPADVLQLPRPSTYP;GLGLADEV;LAEDAPWKKIQ;LDSDKHTIRFIPHEN;LEFLEREHIKLVS;MWEDEDDEDARK;PMPHVEEPADVLQ;SIAVEGPSKAEIAFEDRKDG;VDCSEAGE;VDCSKAGTNMMMVGV;VHFAGAAKGEAVRD;VLFANQEIPASPFHI;YDGHPVPGSPFA 18 7.8 1.0004 -2.8169 0 0 11.0146 10.1859 9.31872 10.6818 9.7634 9.96067 9.13796 11.4727 11.0167 5.08108 12.0405 0 13.6664 A0A8C0PMV9 A0A8C0PMV9_CANLF MDS1 and EVI1 complex locus MECOM Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; histone H3K9 methyltransferase activity [GO:0046974] ARPTPFFMDPIYRVE;EVCHKSYTQFSNLCRHK;GPYVGEQRSNLKDPS;GVASTPSLNIQE;HKRMHADCRTQIK;ITGKTGKEPVTSN;PGPSKPPATPATSQD 7 8 0.98817 -0.37511 0 5.57912 0 0 9.80405 0 7.8387 9.06437 0 0 0 0 0 0 0 A0A8C0PMW2 A0A8C0PMW2_CANLF Triadin Canis lupus familiaris (Dog) (Canis familiaris) heart contraction [GO:0060047]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] DGDEDDDDGDEDTDKGEIEEPPL;GDEDDDDGDEDTDK;SDGDEDDDDGDEDTDKGEIEE;VTTFSSPAAWLLVIALII;YGFFSLLSDIISSDGDEDDDDGDE 5 20.1 0.74359 0.2438 0 0 7.07692 0 0 0 5.12553 0 9.63032 0 0 0 0 6.39857 8.14776 A0A8C0PMX0 A0A8C0PMX0_CANLF Family with sequence similarity 126 member A HYCC1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GAVEEWLSEFKTLP;LVSSLYKVIQEP;VGCGPGTDANR 3 7.7 1.0039 -0.81391 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1979 A0A8C0PMX1 A0A8C0PMX1_CANLF Tankyrase 1-binding protein C-terminal domain-containing protein KIAA1671 Canis lupus familiaris (Dog) (Canis familiaris) DNAWMFKDSTEEK;LVTTTVGHERTSG;VLPSSMEKDEREG 3 10 0.98536 -0.23731 0 0 0 0 0 0 0 0 14.1911 0 0 0 0 0 0 A0A8C0PMX5 A0A8C0PMX5_CANLF RPA interacting protein RPAIN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] FRQGCLERMRN;VLEEIQQELADQERSILTEYEQ 2 10.7 0.98372 -0.24213 8.30542 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PMY3 A0A8C0PMY3_CANLF Hermansky-Pudlak syndrome 6 protein homolog Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; protein localization to membrane [GO:0072657] BLOC-2 complex [GO:0031084]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783] EDILWDPGTPPPT;EEGTRPEALELELL;ELLCQCLCQL;RALEAGLALSPSSPL;VLSTDRVHLLAPPVPGMED;WRLLRSTELCPGG 6 10.5 1.0012 -0.95022 8.40403 0 0 0 0 0 9.2379 0 0 8.0294 0 0 0 0 10.262 A0A8C0PMZ2 A0A8C0PMZ2_CANLF RNA-binding protein 38 (RNA-binding motif protein 38) Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] cytosol [GO:0005829]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730] ALALCWRWH 1 3 1.0035 -0.80421 0 0 0 8.7766 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PMZ7 A0A8C0PMZ7_CANLF CD226 molecule CD226 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of natural killer cell cytokine production [GO:0002729] membrane [GO:0016020] DTLTQMEWFKI;GAVLLLLLVIL;GAVLLLLLVILITTIIVISYK;GAVLLLLLVILITTIIVISYKRRR;LLLLLVILITTIIVISYKR;MQVARILQWVCRGCTARGM;RGCTARGMANVHMELTSAFL;RSTFIIMPHVTASDSGL;TVKLAENMSLQ;VLLLLLVILITTIIVIS 10 25.1 0.98223 -0.24835 0 0 0 0 10.4208 0 10.4861 0 0 0 0 4.7132 5.236 11.7199 9.97025 A0A8C0PN02 A0A8C0PN02_CANLF "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (Keratin-8) (Type-II keratin Kb8)" KRT8 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363] structural constituent of skin epidermis [GO:0030280] EVKAQYEDIANRS;VDEAYMNKIELESRL;VGSITAVSVN 3 7.7 1.0028 -0.72883 0 10.117 0 0 0 0 0 0 0 0 0 0 0 10.2523 0 A0A8C0PN22 A0A8C0PN22_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] APGSQPQPQPQPQSPED;GETRVARRRRRRRRRRL;VPRPDPVAG 3 13.5 0.98782 -0.47039 0 0 5.2555 0 0 0 0 0 0 0 0 7.76129 0 0 4.52563 A0A8C0PN27 A0A8C0PN27_CANLF SET domain-containing protein 2 SETD2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975] DDTCMLHSKSGSP;DESLIFKSEFI;DRRGRSEISLDEE;DSLTLLQCGENTSP;ESDEDSVRTSSSQRSHDLK;GNGYWDPRS;HPTPEEEENE;NCSRFMNHSCEPNC;QLPESKVESEITVEA;QVLSLSRLMV;REAEPPVSPHQDKLMSLPVM;SRFMNHSCEPNCE;STKLSTEADTDTPK;TLLQCGENTSPVLDAVL;WEDERLESRRHSYEEK;WSSCALFHHPSCDL 16 8 0.99723 -3.8892 4.44579 4.54751 0 6.2278 0 8.79633 0 10.4818 16.9374 9.35398 9.59917 9.92406 0 0 0 A0A8C0PN31 A0A8C0PN31_CANLF Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] SEIISSISDVK;TRHTGAAPSISRS 2 5.7 0.98649 -0.41066 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.63983 A0A8C0PN37 A0A8C0PN37_CANLF WBP2 N-terminal like Canis lupus familiaris (Dog) (Canis familiaris) transcription coactivator activity [GO:0003713] ITGQGGVM 1 3.4 0.98878 -0.26277 0 0 0 0 0 0 0 11.5734 0 0 0 0 0 0 0 A0A8C0PN54 A0A8C0PN54_CANLF Family with sequence similarity 189 member B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAIICTLSAI;APERSVSGPLGS;HTLAPERSVSG;SGSLTPPG;TLSAIICCIQIFSLDLVH 5 7.8 1.0029 -0.77711 14.0915 13.8997 11.2148 13.0908 13.2339 13.3585 0 13.8896 13.8573 13.7464 13.9535 0 13.2343 13.1471 13.3341 A0A8C0PN57 A0A8C0PN57_CANLF CDAN1-interacting nuclease 1 CDIN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GVLANQVYQCIVNDCCYGPLVDC;WSYWNRKQLLPDSKAQP 2 15.4 0.98354 -0.25675 0 9.24127 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PN58 A0A8C0PN58_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] HSQARAAAPPAPYARGD;KMFDNGNFRRKRKRR;VGAAGSGA 3 12.5 0.98801 -0.48372 0 0 0 0 0 0 0 0 9.73858 0 0 9.63566 0 0 0 A0A8C0PN59 A0A8C0PN59_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DTLMRTGVYNHE;KKGSTEINQRPVTVE;KREQESQMARLKK;LELEMWKEMQEDIFENQLRQK;PPTKDDATGSE;QESQMARLKKQQEELEQMRL;TELAWEIDRKALHQHRLQRTPIKLQ;TLIDLEKREQQ 8 12.7 0.99195 -0.20865 0 12.9144 9.96196 6.99356 11.0952 7.21616 8.3147 0 8.2211 0 3.41832 7.51767 0 0 13.0644 A0A8C0PN60 A0A8C0PN60_CANLF Activity dependent neuroprotector homeobox Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DPKGHEDDSYEA;EPKIPNDNPEEHL;GVAEPMHGSL;QVTAMIGHTNV;TEEPTKLMHDASD;TPFLPCSLDHIVNSHRGSTSQG 6 7.1 1.0019 -0.90882 0 0 0 0 0 0 10.918 0 12.3443 7.6532 0 0 9.42897 0 0 A0A8C0PN75 A0A8C0PN75_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) SSH1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721] EATLPWQELTHS;ENVTSKEIRNELETQ;LLLKNSHCDKNPPSMEVAKD;LPPAGSRRSDTGGSGAAAAPEL;PDSPALFVDKP 5 7.6 0.98557 -0.23667 0 9.13134 8.88753 0 0 0 0 9.13312 0 8.76308 0 8.84768 8.81182 0 0 A0A8C0PN77 A0A8C0PN77_CANLF Transient receptor potential cation channel subfamily M member 3 TRPM3 Canis lupus familiaris (Dog) (Canis familiaris) protein tetramerization [GO:0051262] membrane [GO:0016020] calcium channel activity [GO:0005262] APTDRPPSRSID;EQAMLDALVLDRV;GVSMHRFLTI;SAFHSFESK 4 2.6 1.0027 -0.77555 14.1395 0 0 0 0 0 0 0 12.723 0 0 0 0 10.2059 0 A0A8C0PNC8 A0A8C0PNC8_CANLF Myelin basic protein MBP Canis lupus familiaris (Dog) (Canis familiaris) myelin sheath [GO:0043209] structural constituent of myelin sheath [GO:0019911] SQQPDLVP 1 2.7 1.0031 -1.1044 0 10.0261 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PND3 A0A8C0PND3_CANLF Pumilio homolog 1 PUM1 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; regulation of chromosome segregation [GO:0051983]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730] AAQAAVAAAAASANGAAGG;DLYKRTSS;GFGSSSSL;GLGVSMVEYV;GNCQNSANEVDLLGPNQ;GVKGVGGM;YVVQKMID 7 6.4 0.99908 -3.2028 0 0 8.41485 10.156 0 0 3.55152 9.40227 13.6299 0 0 0 0 0 0 A0A8C0PND7 A0A8C0PND7_CANLF Uncharacterized protein USP8 Canis lupus familiaris (Dog) (Canis familiaris) KKLLKKLKDSLKALN 1 13.9 0.9506 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 3.5876 0 A0A8C0PND8 A0A8C0PND8_CANLF F5/8 type C domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] extracellular region [GO:0005576] copper ion binding [GO:0005507] AYYSAVNPE;EGFRNQEHAR;GILGPVIRAQVRDTLKIV;IGPWKDLPNDL;IGQMFPSLEPEAW;IPANMDKKYRSLHLDNFS;LKKSLFLIKTRKKKKE;LVSATSTTANMT;MSSGPELFSIHFNGQVLEQNH;PEDNGDEND;TELDSKPWIQ;TTLSPDLSKATLFPDFDQT 12 7.7 1.001 -2.7188 10.7256 0 10.63 0 0 6.56096 3.5097 8.09344 0 8.0873 0 9.73804 9.36109 0 9.09305 A0A8C0PNE0 A0A8C0PNE0_CANLF Transmembrane protease serine (EC 3.4.21.-) LOC611685 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] IDCGKKNKPG;LIVIAVVLVLAIIIGLLVYFL;SLPYLRDMNEAQAEHI;TALIVIAVVLVLAIIIGLL;TILGRRTSSLRPWMTALIV 5 15.1 0.98605 -0.41579 2.6085 0 0 8.97011 0 7.17503 0 0 7.99639 9.13965 0 0 0 5.07468 5.56882 A0A8C0PNF1 A0A8C0PNF1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCSSSSPCQSSCCRQ;CCKPVCCTPVCSSPCCQQ;CCQQSSCQPSCCNSSPCQ;CQPSCCNSSPCQEDSCVSVCCK;DCCQLSCGSCSPCQ;QPSPCRPS 6 30.5 0.8507 0.15578 0 0 0 0 0 8.21456 8.32094 0 0 0 0 0 7.86518 0 0 A0A8C0PNG4 A0A8C0PNG4_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042]; exocytosis [GO:0006887] cytoskeleton [GO:0005856] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] ADVHWTHIRERE;ASKSFGPGHEEDEEEEEYEEEEEE;DEQNVEKNNQ;EDEEEEEYEEE;EDEEEEEYEEEEEEEEEEY;EDEEEEEYEEEEEEEEEEYEEEE;EDEEEEEYEEEEEEEEEEYEEEEEE;EEEEEEEYEEEEEEEESSEEGEY;HEEDEEEEEYEEEEEEEEEEYEEEE;QLSFSEDSDLSSDD;TLLDKKELGSIKKEFP 11 4.3 0.92877 0.095486 7.851 0 0 4.68066 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PNG6 A0A8C0PNG6_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] membrane [GO:0016020] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] GAGREREPQPEPQP;GGGGGGGA;GGGGGGGG;TEGCDHMTCSQ 4 6.5 0.99129 -0.27682 0 0 0 0 0 0 0 6.30719 0 0 0 0 0 0 0 A0A8C0PNH6 A0A8C0PNH6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VLFFFKQYNCYLI 1 11 0.9391 0.059751 0 0 0 0 0 0 6.56774 0 0 0 0 0 0 0 0 A0A8C0PNI9 A0A8C0PNI9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EISRCRQRGQDKEREERLEQGE;QLHRQLFQEE;QLVLECLWQALLVITGSWGH 3 9.8 0.99229 -0.16715 8.52176 0 0 7.69968 0 0 0 0 0 0 7.76388 0 0 0 0 A0A8C0PNJ2 A0A8C0PNJ2_CANLF Abelson helper integration site 1 AHI1 Canis lupus familiaris (Dog) (Canis familiaris) AAKSTGPGVQKNRSPNC;CERHHETNSVD;DLIQERKKLKK;EEMAKEIKKKIRKK;IHVIDENTGQYV;KKIKKKKKVPISSKA;LPEWEEQIIFNENFPYLLRD;PISYLEVH;SEKKIKKKKKV;SEKKIKKKKKVP;SEKKIKKKKKVPISSKAE;SKKKKKKA;VTSDSHQDGKISSM 13 12.3 0.98199 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 9.77785 0 0 A0A8C0PNK5 A0A8C0PNK5_CANLF Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase) PTGIS Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]" LLLGLLAALLLLLLLLSRRRT;LLLLLLLL;PTLLHKDLQALTDSM;RRTRRPGEPPL;TTLPQKLLDNMPVLDS;YAISSIKQFV 6 14 0.98653 -0.42417 7.58916 4.46578 0 0 0 0 0 0 8.47176 0 0 0 0 0 10.7979 A0A8C0PNL0 A0A8C0PNL0_CANLF DAGKc domain-containing protein SPHK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; D-erythro-sphingosine kinase activity [GO:0017050] HKDGVSGAGLWGRDA;PPGCPGREP;SPLHRSVSDLPL 3 6 1.004 -0.80747 0 11.4197 11.5523 0 0 0 11.8545 11.5975 0 11.1393 0 11.0513 0 11.7014 11.3227 A0A8C0PNM3 A0A8C0PNM3_CANLF Cyclin K CCNK Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] ATEARYRREGAR;PLSAPLGEAEPPG 2 4.3 0.87691 0.1269 0 0 0 0 0 0 0 0 0 0 8.90289 0 0 0 9.02907 A0A8C0PNM4 A0A8C0PNM4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;HKLPKLEQEETE;HSKKFGRTSSTWRLRT;IVKMSTLPRAIYTFNA;MDAFLESHKL;MNEKGEITTNT 6 9.6 0.99363 -0.13188 9.10813 0 0 8.28813 0 0 0 6.79999 0 0 0 0 0 0 0 A0A8C0PNM5 A0A8C0PNM5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LVWWRPREGHGRRDGK;PGSRVPGSAPS;SEETRDGGRKDS 3 11.5 0.99604 -0.09566 0 0 0 0 13.4194 11.5059 0 0 0 0 0 0 0 0 0 A0A8C0PNM7 A0A8C0PNM7_CANLF BCL2 interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484] EFKSMSGT;VLYIVKKRLFPFLL 2 9.4 1.0045 -1.0436 0 0 0 0 0 0 0 0 5.16157 0 0 0 0 0 11.2404 A0A8C0PNM9 A0A8C0PNM9_CANLF Small-subunit processome Utp12 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] ELPEFNLIH;ISKLCDWNRYN;RVRAGSGSGSGVRGPR;RWRPAGSPVPPPPP;SLDLYTLSQDGALCVW 5 6.4 0.99425 -0.019135 0 0 7.16822 10.7246 0 0 0 9.02217 8.53877 0 0 8.79497 0 0 0 A0A8C0PNN2 A0A8C0PNN2_CANLF BRCA2 DNA repair associated BRCA2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] DIHFQSPESFSFDCDNTS;DMRIKKKQRQHIFPQP;EIMSPGREADTDP;KKLFSDLENI;KREPRVQNTSDLKRTSLRLQRQQ;LPKSVSYTNACGIFS;NFNTIQKL;NNEMNYQSPLS;NSVPAYSTV;PTEESGYK;SKDPENYFETE;SWSSSLATPPTLS;TCNSESDGSDSS;TEKETAKKPTMYTNQSTYSAIENSP;TPEYEETHSSLE 15 5.9 1.0013 -2.6858 4.86903 0 10.1823 10.2007 9.93789 0 0 7.45738 0 0 10.7655 11.8096 9.53271 0 0 A0A8C0PNP4 A0A8C0PNP4_CANLF "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)" NDUFA9 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] IFLEWDGRNKDSIQ 1 2.8 0.9963 -0.11355 0 0 10.924 0 0 0 0 11.4943 0 0 0 0 0 11.4597 11.4767 A0A8C0PNP6 A0A8C0PNP6_CANLF Fibroblast growth factor (FGF) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083] LIGLEHGPQGGPPTPGDETYVL 1 9.4 0.95121 0.049805 0 0 0 0 0 0 0 0 0 0 0 0 0 9.30481 0 A0A8C0PNQ5 A0A8C0PNQ5_CANLF "phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" GPPALSPQPYCAP;PAPPPAGPALPPPP;PLLPPRPRLPLLLLPR;PPPPRPLPLLPPRPRLPLL;PRPLPLLPPRPRLPLLLLPRLL;SPLLLLRK 6 8.6 0.98367 -0.24781 0 0 0 0 0 0 0 0 0 0 0 0 0 12.7412 0 A0A8C0PNQ6 A0A8C0PNQ6_CANLF MYB binding protein 1a MYBBP1A Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730] DNA binding [GO:0003677] DDKHSASEEDSDEEDSD;DPEWEQLVGQILA;EDSDEEDSDEEDRDGD;ETARPCYSVALAQAMMRPALFA;FSHICSHLTPRALQLILDVLNPEQS;HLQEQPQKALVDIL;HSASEEDSDEEDSDEED;LHVPERAVLRLRKWVILRLV;SEEDSDEEDSDEEDRDGDVDQ;SPLTIPMFLSL;STSGQKKAQDASLHVPE;VERLVEQA 12 12.4 1.0031 -1.5327 0 8.84464 0 7.72601 7.80426 9.40867 0 0 6.46015 0 0 6.52009 9.93407 8.64911 2.78096 A0A8C0PNR0 A0A8C0PNR0_CANLF Phosphorylase b kinase regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] plasma membrane [GO:0005886] calmodulin binding [GO:0005516] GIDLMSPSFLSPGP;TPQFIDQQQFYLALD;VILIIWVFFTTLKILSGLKDMKE 3 6.4 0.97884 0.046279 4.39643 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PNR7 A0A8C0PNR7_CANLF SH3 domain-containing protein EVPL Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoskeleton [GO:0005856] ECKNLQVQ;EEAGRRRQLEREVQQLR;ELHRECKNL;EVVEFYRDPQ;LERLEEKEVVEFYRDP;QAPTGSAP;SPATQGSG;TEVAAAHQQ;VLEGERSRAWE 9 4 0.99718 -3.8923 10.2154 0 9.67488 0 0 0 9.03705 0 11.024 0 0 0 9.73483 0 10.0101 A0A8C0PNT5 A0A8C0PNT5_CANLF Galactocerebrosidase (EC 3.2.1.46) (Galactosylceramidase) GALC Canis lupus familiaris (Dog) (Canis familiaris) galactosylceramide catabolic process [GO:0006683] lysosome [GO:0005764] galactosylceramidase activity [GO:0004336] RRRVRAGRLRR;VGAKHYHDLDIDYIGIWNERS;VWYTKLGKPSE 3 6.9 0.98677 0.035491 0 0 0 0 0 0 0 0 0 0 3.11225 0 0 0 0 A0A8C0PNU1 A0A8C0PNU1_CANLF Peptidase metallopeptidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AVVLPVLLLLLVLAVGLAV;FWRVRNNQ;HWVFDEASL;LVAVHELGHA;RGIQQLYGSESGSPTKM;VVLPVLLLL 6 11.6 1.0034 -2.0743 0 0 9.01511 0 9.5006 6.43496 0 0 6.53739 0 9.33447 0 0 9.28017 0 A0A8C0PNV1 A0A8C0PNV1_CANLF GIT Spa2 homology (SHD) domain-containing protein GIT1 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; regulation of ARF protein signal transduction [GO:0032012] GTPase activator activity [GO:0005096] CAYDIAKAAKQLVTITTREKK;DEVDRRENDAVWLAT;LVECQYELTDRLAFYLCGRKPDHKN;SIWEHSLLDPA 4 10.3 0.98595 -0.24596 0 0 0 9.8378 0 0 0 0 12.0874 10.4535 0 0 12.1463 0 8.76944 A0A8C0PNV6 A0A8C0PNV6_CANLF C2H2-type domain-containing protein ZNF236 Canis lupus familiaris (Dog) (Canis familiaris) ATLNSSELNATTGSLPSTTPMSPSA;EAEGGDVCMEEEEENSER;EQVLVQSAAE;EVKNGPTYNCTEC;GGDVCMEEEEEN;LAQQLQQHQQASSIDDS;NGSIRLSAPAA;SAAEKDRISEM;SYTGNLQEPV;VSTHMQVE 10 6.6 0.01087 1.1693 0 9.21126 7.19446 9.79185 9.97528 10.2229 6.32427 0 0 6.56966 0 6.47528 2.31875 14.9866 0 A0A8C0PNV7 A0A8C0PNV7_CANLF Glutamate ionotropic receptor NMDA type subunit associated protein 1 GRINA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GALLFTCFLAVDTQ;YPGGPQPSMPPYPGA 2 8.1 0.99571 -0.19034 0 0 0 0 0 0 13.5022 0 0 0 0 0 0 0 0 A0A8C0PNV8 A0A8C0PNV8_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] IPSSLNVRGFMCQGP;IVSLNNDQLLKGDFRLQ;LSVHFVNDTSIQ;VPVGLPVD 4 8.4 1.0023 -1.3976 0 10.0419 7.89785 14.0023 0 0 0 0 4.68975 0 0 0 0 0 0 A0A8C0PNZ8 A0A8C0PNZ8_CANLF Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (EC 1.1.1.189) (EC 1.1.1.196) (EC 1.1.1.197) (EC 1.1.1.71) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] carbonyl reductase (NADPH) activity [GO:0004090] SPVPAIFY 1 1.8 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 8.06032 0 0 0 0 A0A8C0PP14 A0A8C0PP14_CANLF TATA box-binding protein-like 1 (TATA box-binding protein-related factor 2) (TBP-like factor) (TBP-related protein) TBPL1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] nucleus [GO:0005634] DNA binding [GO:0003677]; general transcription initiation factor activity [GO:0140223] ARLIIILVLQLILRVRRN;ETGERARLIIILVLQLILRVRRNRQ;IIILVLQLILRVR;ILVLQLILRVRR;WSSGKIICTGATS 5 18.8 0.73252 0.25355 0 0 3.88792 0 0 0 0 0 0 0 7.97573 0 0 6.99865 0 A0A8C0PP36 A0A8C0PP36_CANLF Homeobox domain-containing protein BARX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" PSLLCPCPWVPQHSPHS 1 5.3 0.98505 -0.25894 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.40584 A0A8C0PP52 A0A8C0PP52_CANLF Collectin-12 COLEC12 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; membrane [GO:0016020] carbohydrate binding [GO:0030246] CPPHWKNFTDKCYY;EERFQLFETDI;EERFQLFETDIVNI 3 3.8 0.98812 -0.4772 0 0 0 0 0 4.81435 0 0 0 0 10.3982 0 0 0 0 A0A8C0PP87 A0A8C0PP87_CANLF Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) ETNPPL Canis lupus familiaris (Dog) (Canis familiaris) lyase activity [GO:0016829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] IYKMKEKRVLLSAD;NSGSEANDLALRLARQFRG 2 7.5 0.99402 -0.16186 0 0 0 0 0 0 11.5432 0 0 0 0 0 0 0 0 A0A8C0PPA9 A0A8C0PPA9_CANLF F-actin-capping protein subunit beta Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; negative regulation of filopodium assembly [GO:0051490]; regulation of lamellipodium assembly [GO:0010591] cytoplasm [GO:0005737]; F-actin capping protein complex [GO:0008290] actin filament binding [GO:0051015] DSIHVVEVQ;LVEDMENKIRSTLNEIY 2 10.7 0.97646 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 7.51175 0 0 A0A8C0PPB2 A0A8C0PPB2_CANLF "Calcium-activated potassium channel subunit beta (BKbeta) (BK channel subunit beta) (Calcium-activated potassium channel, subfamily M subunit beta) (Charybdotoxin receptor subunit beta) (K(VCA)beta) (Maxi K channel subunit beta) (Slo-beta)" KCNMB2 Canis lupus familiaris (Dog) (Canis familiaris) detection of calcium ion [GO:0005513] voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459] DTFNCSFSCGPDCW;TEESQCTL 2 10.2 0.98637 -0.45023 5.12846 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PPB4 A0A8C0PPB4_CANLF Collagen IV NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] APGPKGEPGFQGLP;ATRCPFHSPQH;EAGLPGQPGPTGPAGQ;EKGERGYPGAPGLRGE;GVSGPPGVPGQAQVQE;HQSEPTPGAHDSP;PGAPGPKGE;SGYPGNPGLPGIPGQDGPPGPPG;VGGMGLPG 9 7 1.0036 -2.2344 0 0 0 0 9.57476 8.84043 8.20535 10.8523 11.4193 0 10.9176 0 0 0 9.49408 A0A8C0PPC4 A0A8C0PPC4_CANLF Regulator of G protein signaling 3 RGS3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTPase regulator activity [GO:0030695] AEEAEEGDEGDEEEEEEDDTSDD;DDTSDDNYGE;DEEEEEEDDT;DEEEEEEDDTSDD;EAEEGDEGDEEEEEEDDTSDD;EEEEDDTS;EGDEGDEEEEEEDDTSDDNYGER;GAEGGSPAEEEEDAEEAEEGDE;KHLKVARRRLRPLRD;LLGEDLGRTKHLKVARRRLRPLR;PPGPPGPSGRAAGCGLRAAGCGER;SLLTPDKEISGWY;SPAEEEEDAEEAEEGDEGDEEEEEE;VPDCREPVF 14 8.5 1.0036 -2.048 8.26646 6.92588 9.23062 4.8955 6.4928 6.18971 0 5.30228 8.94184 0 0 3.54486 7.15532 0 6.61226 A0A8C0PPD5 A0A8C0PPD5_CANLF AMP-dependent synthetase/ligase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FLLLNAKG;MSHAATSALCRSIKLQCELY;NVGDHVALVYPPGVD 3 2.9 1.0019 -1.0018 6.19466 8.25776 0 0 0 0 0 0 9.00084 0 0 0 0 0 0 A0A8C0PPE2 A0A8C0PPE2_CANLF Kinesin family member 24 Canis lupus familiaris (Dog) (Canis familiaris) APLEPATFPPIS;GVPLLGRNK;VVVTGEGSDSNRDTVP 3 9.2 0.99441 -0.56219 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.90454 A0A8C0PPI1 A0A8C0PPI1_CANLF Tripartite motif-containing protein 44 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DEDSEEDSEEDMEDEQDSD;DLESESDEDSESEEDS;DLESESDEDSESEEDSGT;DLESESDEDSESEEDSGTDEDSEE;DSEEDSEEDMEDEQDSD;EDSGTDEDSEEDSEEDMEDEQ;IELVERLKFKSSDPKVTRD;LICVLCPV;SEEDSEEDMEDEQDSDA;TDEDSEEDSEEDMEDEQDSD;TDEDSEEDSEEDMEDEQDSDA 11 19.3 0.85319 0.1925 0 0 0 0 3.97095 0 6.04991 6.56272 0 6.63541 0 0 0 6.4492 6.13683 A0A8C0PPJ2 A0A8C0PPJ2_CANLF SOCS box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] NVDLIEMLVEFGGNIYAR;PGAAELQLPGA;PLYTASPLHEAC;SGRPEKPG 4 8.3 1.003 -1.3315 0 10.041 0 8.86143 0 0 0 0 0 0 4.95745 0 0 0 0 A0A8C0PPK1 A0A8C0PPK1_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] CDADGIAQTCNAE;DNPPRFPRRSYQYNV;ILACVLTLLVLILLIVTMRRRK;MEREFIDKTQ;TLLVLILLIVTMRRRK;TRRNGFRRQEQSVYYLPI;VLTLLVLILLIVTMRRRKK 7 10.7 0.99038 -0.20154 0 0 0 0 0 0 0 0 0 0 0 0 10.5248 0 0 A0A8C0PPK4 A0A8C0PPK4_CANLF Family with sequence similarity 163 member B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HYEPPAFFLQEPEDES;LQYYCCKKDESEEDEEEP 2 20.9 0.99168 -0.18125 0 0 0 0 0 0 0 11.2718 0 0 10.9765 0 0 0 0 A0A8C0PPK8 A0A8C0PPK8_CANLF Dihydropyrimidinase-related protein 2 DPYSL2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] cytoplasm [GO:0005737]; membrane [GO:0016020] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" ITEWHKGI;KIVLEDGTLHVTEG;LGITGPEGHVLSR;SPSLHGCG;TSPPLSPDP 5 8.8 1.003 -1.9591 0 0 0 8.03408 0 8.35544 0 0 0 0 0 0 8.9202 3.514 0 A0A8C0PPK9 A0A8C0PPK9_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] GAIIIIIRKGKPVNM;GGLAVLILLLGAIIIIIRKGKP;GGLAVLILLLGAIIIIIRKGKPV;GLAVLILLLGAIIIIIRKGK;ILLLGAIIIIIRK;ILLLGAIIIIIRKGK;LAVLILLLGAIIIIIRKG;LAVLILLLGAIIIIIRKGKP;LAVLILLLGAIIIIIRKGKPV;LLLGAIIIIIRKG;MLDMAECEGV;VGRVKCSRYW;VKMEQGVSRYTIKNLLPYR;VLILLLGAIIIIIRKGKPV;VSTFWPNEYQVLFEAL;WEQVHIHPGTR 16 6.3 0.98684 -0.37992 8.46418 7.42114 8.2948 6.0152 0 6.55556 5.17556 0 1.10575 0 0 9.45354 6.67143 6.24445 3.38364 A0A8C0PPL8 A0A8C0PPL8_CANLF Sulfotransferase (EC 2.8.2.-) LOC482182 Canis lupus familiaris (Dog) (Canis familiaris) 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; sulfation [GO:0051923] cytosol [GO:0005829]; nuclear membrane [GO:0031965] flavonol 3-sulfotransferase activity [GO:0047894]; steroid binding [GO:0005496]; steroid sulfotransferase activity [GO:0050294] IRKEVIKVMQ;LNEKFDIHYEQQMK;MQFLGRQPTEE;YKDFMKYWDDVETF 4 15.9 1.0039 -0.82479 10.3106 0 0 0 10.7951 0 0 0 0 0 9.63968 0 0 0 0 A0A8C0PPM2 A0A8C0PPM2_CANLF Nucleoside-diphosphate kinase Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] ATP binding [GO:0005524]; nucleobase-containing compound kinase activity [GO:0019205] DLNTEDETVLNYFDEIEIH;IVTPKDEGEEEEEGEEE;SLEEITEEEEEED 3 6.8 0.98765 -0.50463 0 8.0984 0 0 0 0 0 10.9444 9.43039 0 0 9.21919 0 0 0 A0A8C0PPP9 A0A8C0PPP9_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVGDGPAEAAETFPA;PDPMHHLLNL 2 5.1 0.99178 -0.27208 0 0 12.0989 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PPQ6 A0A8C0PPQ6_CANLF GDNF family receptor alpha-2 GFRA2 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] glial cell-derived neurotrophic factor receptor activity [GO:0016167] FCFLFFLDETLRSLASPSSL;SYEDKEKPN;SYISICNREISPTER 3 9.5 0.96185 0.04875 0 8.00865 0 0 0 0 0 0 0 0 0 0 9.12073 0 0 A0A8C0PPR3 A0A8C0PPR3_CANLF Bromodomain containing 4 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] GRGARHFLPP;LENNYYWNAQECIQDFNTMFTNC;LRKKRKPQAEK;MRSREDEDALEQA;NYYWNAQECIQ;QLAALSQPQQ;QQPPPPPPPQ;QVLLQEDEEPPA;REYRDAQEFGADVRL;VGRPVIRP 10 7.4 1.0033 -2.0794 0 7.85119 7.96544 6.23716 10.1964 10.1655 8.31229 10.3811 9.69853 9.00017 0 8.75452 9.84842 7.71939 9.62368 A0A8C0PPR5 A0A8C0PPR5_CANLF Elongator complex protein 3 (EC 2.3.1.-) ELP3 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; tRNA binding [GO:0000049]" DIPMPLVSSG;ELMMLTIGDVI;VAHMMPDL;YCPGGPDSDFEYSTQSYTGY 4 9.9 1.0031 -1.3364 0 0 0 0 13.2064 0 0 0 0 10.4827 0 0 0 0 0 A0A8C0PPS7 A0A8C0PPS7_CANLF Potassium inwardly rectifying channel subfamily J member 14 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] EVDYRHFHRTYE;FQRGSQYEVDYRHFH;SCCQEEDEEEE;SCCQEEDEEEES 4 7.2 0.85804 0.19025 4.90391 0 0 0 0 7.63343 5.6399 0 0 0 0 0 0 4.23051 5.96542 A0A8C0PPT5 A0A8C0PPT5_CANLF MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like) MAPK1IP1L Canis lupus familiaris (Dog) (Canis familiaris) ISKRRKSRSSPQ 1 2.6 0.95314 0.05044 0 0 0 0 0 4.58743 0 0 0 0 0 0 0 0 0 A0A8C0PPU5 A0A8C0PPU5_CANLF IF rod domain-containing protein IFFO2 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] AVALGGLPPG;GGGGGGGA;GGGGGGGG;NQLRETFDFDDDCDSLTWEENE;PGGGGGGG;QPAAWPISPAHPSIRP;RLIKGSADRYPPPSSR;RRLRYKTFSR;RRTGGGGV;WEENEDTLLLWEDFTNC 10 20.8 1.0019 -1.3018 0 0 12.0134 0 0 0 0 9.2226 9.35407 8.74483 0 0 0 0 0 A0A8C0PPU9 A0A8C0PPU9_CANLF PH domain-containing protein OSBPL5 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] cholesterol binding [GO:0015485] ALELALRCSSL;DLLRQTPG;ITQPLPSSYLIFRAASE;RRTTYVEQVHEE;TMELGGRVTIE 5 6.6 1.003 -1.1044 6.68524 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PPV3 A0A8C0PPV3_CANLF Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GVCILEEPL;RQKQLRRKNVRFDQVTVYY;TSVPSQGG;VEVDDYFFLQ;VGNASTLEALV;VGNASTLEALVPE 6 10.9 1.0023 -0.72465 8.11421 3.99702 0 0 0 0 9.81243 9.24534 0 0 0 12.7092 0 0 0 A0A8C0PPX8 A0A8C0PPX8_CANLF Taste receptor type 1 member 2 (Sweet taste receptor T1R2) TAS1R2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; sweet taste receptor complex [GO:1903767] G protein-coupled receptor activity [GO:0004930]; sweet taste receptor activity [GO:0033041] DPVLHNLT;LAFLEWHEPSTIFV;SMCSKDCH 3 3.6 1.0032 -1.5537 0 7.78313 0 0 0 6.73823 7.81192 0 0 0 0 0 0 0 0 A0A8C0PPY2 A0A8C0PPY2_CANLF Zinc finger Ran-binding domain-containing protein 2 ZRANB2 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DKESEGEEEDEDEDLS;EDEDEDDADL;EERTGYGGGFNER;RSRSPERHHRSSSG;SEEEDSNKKKSN 5 20.5 0.98788 -0.36828 0 0 0 9.59662 11.9834 0 0 0 7.87252 0 0 0 0 0 9.19545 A0A8C0PPY9 A0A8C0PPY9_CANLF Tubulin alpha chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] DLVLERIRKL;PEQLVSGKEDAANNYARGRYSVG;SCGGGTGS;SGIIDLVLERIR 4 10.1 1.0015 -1.3124 0 0 0 0 0 0 0 0 10.2987 10.2808 10.1073 7.14934 0 0 0 A0A8C0PQ06 A0A8C0PQ06_CANLF Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (FIC domain-containing protein) FICD Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMPylase activity [GO:0070733]; ATP binding [GO:0005524] GSGRSARAGSLASSSP;VGHHIPPHPQDVEKQMQEFVQWLN;VLGYVDPVEAG 3 9.3 0.98962 -0.51979 0 0 0 0 0 0 10.076 10.6193 0 0 0 0 0 0 0 A0A8C0PQ11 A0A8C0PQ11_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; regulation of DNA-templated transcription elongation [GO:0032784]; signal transduction [GO:0007165] THO complex part of transcription export complex [GO:0000445] LYRKFWSLQDYFRNPVQCYEKISW;SPHFFQPTNQQF;VTFPRDSVSLTGRHSPSFPRAG 3 7.2 0.99436 -0.12246 0 9.91135 0 0 0 0 0 7.82521 0 0 0 0 0 0 0 A0A8C0PQ15 A0A8C0PQ15_CANLF F-box domain-containing protein FBXW8 Canis lupus familiaris (Dog) (Canis familiaris) VLWYRLCQQEGH 1 2.2 0.95167 0.05044 7.39712 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PQ18 A0A8C0PQ18_CANLF GYF domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DIMKMWGR;EEGGECSDSESSHN;EHMERRRRFEF;GREEMLALFLKDNKIPSDLLDK;GVSIPLMHEAMQKWY;HLQYQQFLI;QAEKMVAYLQDSALDDERL;RRFEKPGRKDVGKK;RSSSRGRGRGRGECGF;VGVSNRQNKKVEE;VVGAPRGR 11 11.2 1.0031 -1.9402 8.99251 13.5893 0 6.47377 8.60481 5.90682 9.63241 0 0 7.09835 8.96573 0 0 2.86973 9.49223 A0A8C0PQ27 A0A8C0PQ27_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] GVYFCACDSGSGSQK;IGLRILLL;LVIGLRILLLKVIGFNL 3 12.4 0.95641 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 5.86414 0 0 A0A8C0PQ28 A0A8C0PQ28_CANLF Protein phosphatase 1 regulatory inhibitor subunit 2 PPP1R2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] EDEEMSETAAEESMNTEESNQ 1 10.3 0.9755 0.047166 0 0 0 0 4.32287 0 0 0 0 0 0 0 0 0 0 A0A8C0PQ29 A0A8C0PQ29_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DTQNGDLIVQPE;ISEFSCWQAHANNMF;LPFSGSFQT;LSQSQPFPYTQ;NHLTETYL;VTTAPKTGWNSEG 6 4.6 1.0018 -1.3654 0 11.2372 0 0 1.87818 0 8.90773 0 0 0 0 0 0 0 0 A0A8C0PQ30 A0A8C0PQ30_CANLF Synaptogyrin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSCLTFLA 1 3.4 0.98492 -0.25882 8.20447 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PQ47 A0A8C0PQ47_CANLF PH domain-containing protein PHLDB1 Canis lupus familiaris (Dog) (Canis familiaris) AELLRSITKRKERLAVL;DLEQWYQELM;DPAGQQVIEE;LPSSSSSASLTPSPKMEEL;RVPVTRERKNSITEISDNEDDLLE;VEQLKVRVKELEQQL 6 6.2 1.0026 -1.1966 0 9.78833 10.1063 5.52215 6.88411 0 3.14145 0 0 0 0 0 16.6231 0 8.15264 A0A8C0PQ50 A0A8C0PQ50_CANLF Amino acid transporter SLC1A7 Canis lupus familiaris (Dog) (Canis familiaris) L-alpha-amino acid transmembrane transport [GO:1902475] membrane [GO:0016020] symporter activity [GO:0015293] IINNKILKIYIKIKKKL;KILKIYIKIKKKL;LWGWPGGP;VGWWSTASSSCPCS 4 6.9 0.98741 -0.40082 0 0 0 8.63027 5.67638 3.25169 0 0 0 0 0 0 10.8258 0 0 A0A8C0PQ53 A0A8C0PQ53_CANLF Copine 8 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277] plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544] FDAMVELDGDDVR;RDYIDRSGNHILSMARLA;RKFILDYFFEERENLRFDLYDVDS;VGSSLAKERES 4 10.7 0.9976 -0.098774 0 7.98504 0 0 0 8.11692 0 0 9.71829 0 0 0 0 0 0 A0A8C0PQ54 A0A8C0PQ54_CANLF ETS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" AELGFYFPELVL 1 7.9 0.95233 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.00513 A0A8C0PQ57 A0A8C0PQ57_CANLF ERCC4 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] Holliday junction resolvase complex [GO:0048476]; nucleus [GO:0005634] crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677] DLSRRIYLF;GAGGAGRS 2 4.9 1.0044 -0.80421 0 0 0 0 0 0 0 0 0 5.2592 0 0 7.37495 7.23237 0 A0A8C0PQ89 A0A8C0PQ89_CANLF FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EISIMTLRMFEHL;FTPKLLLVRKRLLG;FTPKLLLVRKRLLGLE;INVHRPVQNK;IQRIPDFTPKLLLVRKRLLGLE;ITLLEGVIVLEEFCKE;LEERNYTEYKPVCP;LLLVRKRLLGLE;LSNQEWLSSSP;PGPRPPRLSRPRRVRPPRR;RFFIGVMEPQLMQT;TVEAINWGLD 12 13.3 0.97394 0.046699 0 0 0 0 0 5.86258 0 0 0 0 0 0 0 0 0 A0A8C0PQ94 A0A8C0PQ94_CANLF Core shell protein Gag P30 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) virion assembly [GO:0019068] GEQLMLYWPFSTSDLYNWKT;PETKAAIMAFVNQ 2 9.6 0.99285 -0.27127 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.63008 A0A8C0PQC5 A0A8C0PQC5_CANLF LIM zinc-binding domain-containing protein AJUBA Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047] metal ion binding [GO:0046872] CYHCEDCRMQLSDEEGCCCF;CYHCEDCRMQLSDEEGCCCFPL;VISMDRDYHFECYH;YHCEDCRMQLSDEEGCC 4 6.1 0.81222 0.2019 0 6.11383 0 4.61153 0 0 0 0 5.43316 6.4833 0 0 0 0 0 A0A8C0PQE0 A0A8C0PQE0_CANLF acetyl-CoA carboxylase (EC 6.4.1.2) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] LAEHARHLEVQ;LGREVYTSNNQ;LTQLSKSEHCKVA;NIVDVELIYGGVKYILKVARQSLTM;QHRQLPDGTCVV;RHLEVQILADQ;SITNPDLLRHST;TILDCHAATL;WVVVDSSINPLCI;YDFPEMFRQALFKLWGTPDKYPKDI 10 6.2 1.0018 -0.96211 0 10.15 5.84202 3.55508 0 0 11.5784 7.85212 0 6.51 10.4668 11.3862 9.09901 11.2662 15.466 A0A8C0PQE7 A0A8C0PQE7_CANLF TOG domain-containing protein CKAP5 Canis lupus familiaris (Dog) (Canis familiaris) establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule polymerization [GO:0046785]; regulation of cellular component organization [GO:0051128]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; kinetochore [GO:0000776] microtubule plus end polymerase [GO:0061863]; microtubule plus-end binding [GO:0051010] AALNTIVTVYNVH;FGSKIILLKPIIKVLPK;FGSKIILLKPIIKVLPKL;GSKIILLKPIIKVLP;GTKSKNSKQRAECLEELG;ILLKPIIKVLP;ILLKPIIKVLPKLF;ISGTDEGEDGDEPDEVGTD;LAVAMGPNIKQ;LLKPIIKVLPK;LVHGKKAG;NDFLAEIFKKI;NILQQLAVAMG;NSINLDRILLDIHI;PEWSKFLGLIKKL;SKIILLKPIIKVLPKL;VLPATCIQLLDSSNWKERLA 17 7.7 1.0023 -1.3998 0 6.46091 0 5.48149 10.4722 5.16165 4.76956 0 11.0411 10.1571 8.53243 8.66487 0 0 9.76095 A0A8C0PQG6 A0A8C0PQG6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LGDPASCCLYLP 1 19.7 0.83442 0.19684 7.85643 0 0 0 7.29315 7.00865 0 0 0 7.67151 8.15249 7.68937 7.96705 0 0 A0A8C0PQG7 A0A8C0PQG7_CANLF EGF-like domain-containing protein LRP8 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] CDEDDDCSDNSDE;CDEDDDCSDNSDEDD;CDEDDDCSDNSDEDDC;CDGDDDCGDGSDERGCAD;CDGDDDCGDGSDERGCADPA;CDGEEECPDGSDESEAT;CDGEEECPDGSDESEATCT;CDGEEECPDGSDESEATCTKQVCP;DDDCGDGSDERGCADPACG;DDDCSDNSDED;DDDCSDNSDEDDC;DEDDCPKKTCADSDF;DEDDDCSD;DEDDDCSDNSDEDDCPKKTCAD;DEPLKECVPPT;DGDDDCGDGS;DGDDDCGDGSDE;DGDDDCGDGSDERG;EDDDCSDNSDED;EDDDCSDNSDEDD;EDDDCSDNSDEDDC;EDDDCSDNSDEDDCP;EDPDACSQICVNYKGYFKCECHPGY;FVCDGDDDCGD;IPSVWRCDEDDDCSDN;RCDEDDDCSDNSDEDDC;RCIPSVWRCDEDDDCSDNSDEDDC;VCDGDDDCGD;VGGGARGSVLGGGLW;VWRCDEDDDCSDNSDEDDCP;WRCDEDDDCSDNSDEDDCPKKTCAD 31 12.6 0.95132 0.053901 0 0 0 0 0 0 0 8.51975 0 0 3.83471 0 0 0 0 A0A8C0PQH9 A0A8C0PQH9_CANLF UBA like domain containing 2 UBALD2 Canis lupus familiaris (Dog) (Canis familiaris) KSGSGAAG;RAWPITSPDEPKHSGRPMRG;RPGAGGGA 3 7.7 0.98733 -0.47783 9.89604 0 9.94017 0 10.56 0 0 0 0 0 0 9.44186 0 0 0 A0A8C0PQI4 A0A8C0PQI4_CANLF Ig-like domain-containing protein SCN4B Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell action potential involved in contraction [GO:0086002]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] voltage-gated sodium channel complex [GO:0001518] sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] GVIGLLIFILLVK;GVIGLLIFILLVKKFI;IFILLVKKFIAF;LLIFILLVKKFIAFIIKKTQ;SLSLEVSVGKATTIY;SSCFGFQDLHFW;VGGVIGLLIFILLVK;VTLIILGVVGGVIGLLIFILLV 8 26.8 0.90389 0.12171 0 0 0 0 0 5.59428 0 8.63492 5.53528 0 13.9493 0 6.51786 4.14437 0 A0A8C0PQI6 A0A8C0PQI6_CANLF Matrix Gla protein (MGP) MGP Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503]; regulation of bone mineralization [GO:0030500] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] calcium ion binding [GO:0005509] CDDFKLCERYAMVYGYNA 1 17.5 0.97668 0.048313 0 0 0 0 0 0 0 8.6453 0 0 0 0 0 0 0 A0A8C0PQL0 A0A8C0PQL0_CANLF Anoctamin ANO6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] EVLLPWIKNLIGRY;FSWFTKVLQVDESI;QEVLLPWIKN;YPGDPTYWLGK 4 4.7 1.0015 -0.64201 0 0 0 0 0 0 4.9103 0 9.76817 0 9.43655 0 0 11.9402 10.107 A0A8C0PQQ3 A0A8C0PQQ3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; Ino80 complex [GO:0031011] cysteine-type deubiquitinase activity [GO:0004843]; proteasome binding [GO:0070628] LTSSAAGL 1 1.6 1.0039 -1.1044 0 0 0 0 0 7.38163 0 0 0 0 0 0 0 0 0 A0A8C0PQR7 A0A8C0PQR7_CANLF RAI1-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EKWPPEEAPTGA;ESEDPSAQGSALF;IHHRLASMYH;ILWTFEDIHMLVGSNMPIFGG;KFLYYSINGDGAAQ;NIKKLLKIPY;QERQHPAAH;SESPLNENSDESYSEEEEEMPDS;TPIPLKYEDESTRGGPE;VPEKYKSIHQIRPSCTFPVCHDT 10 10.4 1.0025 -1.1285 0 8.46793 8.89227 0 0 6.11688 0 12.1958 10.0566 0 9.98598 10.3167 0 11.3045 0 A0A8C0PQU7 A0A8C0PQU7_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] pyridoxal phosphate binding [GO:0030170] AELYFRISDLR;AGSCSCSRSCSCSCS;EVQAPWKQGP;SLHNRLRFL 4 8.1 0.95061 0.053874 0 0 0 0 0 0 0 0 0 0 6.58185 0 0 0 0 A0A8C0PQV4 A0A8C0PQV4_CANLF Dopamine beta-hydroxylase (EC 1.14.17.1) DBH Canis lupus familiaris (Dog) (Canis familiaris) dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589] chromaffin granule lumen [GO:0034466]; chromaffin granule membrane [GO:0042584]; extracellular space [GO:0005615]; transport vesicle membrane [GO:0030658] copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] FKRPFGTCDPKDYFIEDGTVHLVY;GSCDSKEKPQELKVCRHV;ITSCTYNT;TKVVTMLVRDGQEIEIVNRDDHYSP 4 12.3 1.0018 -1.3097 9.30255 6.77584 7.99203 0 0 10.5712 0 0 0 0 0 0 0 0 0 A0A8C0PQV5 A0A8C0PQV5_CANLF Myelin basic protein MBP Canis lupus familiaris (Dog) (Canis familiaris) myelin sheath [GO:0043209] structural constituent of myelin sheath [GO:0019911] CGEEQQGEADVEQNNGTPSQDT;GGAGGELPTRCAPAG;GGGGGGGG;WKLLLLRR 4 9.3 0.98638 -0.45166 0 0 0 5.21237 0 0 0 0 9.08255 0 0 9.89175 0 0 0 A0A8C0PQW7 A0A8C0PQW7_CANLF 5' exonuclease Apollo (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" hydrolase activity [GO:0016787] EIQRTECRMIPLAD;LEKQKPSFL;LLERRLKRPRTQGVV;PVNFFQAQ;QVERYHKPLLE 5 10.4 0.98751 -0.35078 0 0 0 10.9712 0 0 0 7.28882 12.7615 0 0 8.17238 0 0 0 A0A8C0PQX5 A0A8C0PQX5_CANLF C2H2-type domain-containing protein ZNF516 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DDSKILLRSSKKEAEGAVCVPE;DEALAGDVAFDKE;LRKMPQCVCILYSI;PELTPGEFPCEVCGQ;SEEERRVSS;TPTPSVIA 6 7.1 1.0032 -1.9242 9.55683 9.47802 0 0 0 0 0 0 11.0778 9.3675 0 7.58834 0 9.92849 0 A0A8C0PR00 A0A8C0PR00_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] AGAGARGAGAGPARCSAAAR;FHLEYLFIEGN;STDRRDFF;VIRDDAFAGLFHLEYLF 4 8 1.0027 -1.0055 0 0 0 0 0 0 9.92856 8.35918 9.45265 0 3.97554 0 0 0 4.36919 A0A8C0PR15 A0A8C0PR15_CANLF SPATA31 subfamily D member 1 LOC119870824 Canis lupus familiaris (Dog) (Canis familiaris) CNGTTAEINRLLFPE;SCAPGCSFVPPVSCSPQ;VLEEEMGCRH 3 3 0.98771 -0.36865 0 0 0 0 0 0 11.0897 11.6659 9.41517 0 9.03485 0 0 0 0 A0A8C0PR28 A0A8C0PR28_CANLF "Farnesyl pyrophosphate synthase ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (Farnesyl diphosphate synthase) (Geranyltranstransferase)" FDPS Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299] prenyltransferase activity [GO:0004659] DLITAPQGS;GVFLLPASCWA;VLQENYGQKEAEKVA 3 8.9 1.0014 -0.99757 9.95524 0 0 0 0 10.1153 0 0 10.6874 0 0 0 0 0 0 A0A8C0PR32 A0A8C0PR32_CANLF Serpin domain-containing protein SERPINB8 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] AELEELSFAKDTE;AQMSQIRASICDSKVVTLALCLSR 2 12.5 0.98656 -0.40978 0 0 0 0 0 0 0 11.1029 0 0 0 0 10.3276 0 0 A0A8C0PR34 A0A8C0PR34_CANLF VPS9 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FDCYKCHWQEG;PGQDGCMFHLLTP;PQDRTVWQ;SAGCPGDQQEAL;TLVGKGKVTFP 5 5.8 0.99035 -0.53358 12.4522 0 12.3356 0 0 13.0819 0 0 0 0 12.6912 6.53745 13.1239 0 9.62653 A0A8C0PR36 A0A8C0PR36_CANLF Acyl-CoA-binding domain-containing protein 6 ACBD6 Canis lupus familiaris (Dog) (Canis familiaris) fatty-acyl-CoA binding [GO:0000062] INPKSCLFEC;LLDNSFIYCSLL;TKVIRSKNVDVNMK 3 8.8 0.98711 -0.38163 10.2053 0 0 0 0 0 0 0 4.10316 0 0 9.56948 0 0 0 A0A8C0PR43 A0A8C0PR43_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202] ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723] EPGGPGGPA;GAETRRSG 2 3.4 1.0025 -1.3686 0 8.54295 8.27924 0 0 0 0 0 0 8.50668 8.38102 8.30538 0 0 0 A0A8C0PR75 A0A8C0PR75_CANLF Phospholipid/glycerol acyltransferase domain-containing protein AGPAT3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] KWEEDRDTVIQ;PVPTSTGMLMMI;TEKKHRVSMEVAV;YSLWSQLVMLL 4 12.1 0.98923 -0.19978 0 0 0 0 5.31317 9.13468 0 0 9.02414 0 0 0 0 0 0 A0A8C0PR91 A0A8C0PR91_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MARCHF3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVASSTQSLRVPQ;PGPLRPPLASRDRPQRPAAA;RDPQGVWVAPSLSQPG 3 9.9 0.98641 -0.42792 0 9.99237 0 0 0 0 11.5367 0 0 0 0 0 0 0 0 A0A8C0PR92 A0A8C0PR92_CANLF Fas-binding factor 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162] ciliary transition fiber [GO:0097539] EKDQEMERLRELQRASILEMRKDHE;EQSRVESTQRAL;ITKKPPGAA;KLELERAQHQL;SLLPGTEYQRQ;WERAEREAERALQVDTQREGTLV 6 9.6 0.98008 0.035491 0 0 0 0 0 0 7.07371 0 6.59526 0 0 0 0 0 0 A0A8C0PRB7 A0A8C0PRB7_CANLF AT-rich interactive domain-containing protein 5B Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] transcription cis-regulatory region binding [GO:0000976] DLDLVIAGK;GGGAGGAA;TITARRQW;VLSYPQYCRY 4 2.9 1.0032 -2.1468 9.72557 0 0 0 0 0 9.31384 0 0 5.47722 0 0 0 0 0 A0A8C0PRB8 A0A8C0PRB8_CANLF Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) Canis lupus familiaris (Dog) (Canis familiaris) pyridoxal 5'-phosphate salvage [GO:0009443] pyridoxal kinase activity [GO:0008478] AAGYAHWKGQVLN;GAGGGGGG;GAGGGGGGTS;VLNSDELHELYEGLKLN 4 7.7 1.0032 -0.86046 0 0 0 5.75614 0 0 0 0 0 0 10.7785 0 0 0 0 A0A8C0PRC2 A0A8C0PRC2_CANLF Peripheral myelin protein 22 PMP22 Canis lupus familiaris (Dog) (Canis familiaris) myelin assembly [GO:0032288] plasma membrane [GO:0005886] VASLVFDCKEIR 1 4.6 0.95413 0.05044 6.06219 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PRD1 A0A8C0PRD1_CANLF DENN domain containing 1A DENND1A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] guanyl-nucleotide exchange factor activity [GO:0005085] DALLALLDPL;HVYIPVLPPHLLDY;LIVCSKLSTLTAC;VTLGSAAV 4 4.4 0.98998 -0.26592 0 0 0 0 0 0 0 0 0 16.0194 0 0 0 0 0 A0A8C0PRD6 A0A8C0PRD6_CANLF Establishment of sister chromatid cohesion N-acetyltransferase 1 ESCO1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] acyltransferase activity [GO:0016746]; metal ion binding [GO:0046872] AGQKRFGAVSCNVCG;EQSVDNELEQAGRSKRG;FATQYCGTEYSPNMEY;PKCNSHLEITIP;SEKYLQKNVKK;TDNERQILHQKE;TLPEPAICGISRIWVFSMM;VEHQTAYTC 8 13.9 0.96104 0.049233 0 3.70233 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PRG3 A0A8C0PRG3_CANLF Ryanodine receptor 2 RYR2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AENAHNVWARDRIRQGWTYGIQQD;AKSCHDEEDDDGEEE;AQEKPSRLKQRFLLRR;CHDEEDDDGEEEVKSFEEKEM;DENETLDYEEFVKR;DVKYQMWKLG;GLGDIMNNKVFY;GNEHYGRSWQAGDV;IDQYFKNHRLYF;IELLKELMDLQK;IISTVDYL;IKRSNCYMVCAGESM;IVAFSDDFVAKLQDNQRFR;KNDLEDYDADSD;LSLKSLKKQMKRVK;LVPYDTLTAKEKAKDRE;NHKDYAQEKPSRLK;NSEHMNTLLGN;NSIDVKYQMWKLGVVFTDNSFLY;NSSTDIMFYRLSM;PEENRSVDILELTEQEEL;SEDGDTPDMKCDDMLTCYMFHMYV;TEKCKLEEDF;VESSNNVE;VGRMNFGKDVSTL;VSINNECYQ;VVEPDMSAGFCPDH;VVRLLIRRPE 28 7.5 0.99703 -3.6824 10.0902 11.3196 10.5733 0 7.6037 10.3227 15.2448 7.47962 9.30563 0 13.4255 7.5489 11.3584 11.7784 11.5008 A0A8C0PRI9 A0A8C0PRI9_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) MTMR4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721] ECEEYYPNCEVVFMG;GPSAPRQVPFAVL;LDPGTRATGGP;PEDLFAFA;PGTRATGGPLSTG;SHCYNCDCEFW;VLEETKEPAPD;WLDSVHQLLKQ;WVPDHMASHCYNCDCEFW 9 6.9 1.0023 -0.66717 8.20765 0 0 10.4074 0 9.55626 5.64593 0 12.5727 0 4.68139 0 0 0 0 A0A8C0PRJ0 A0A8C0PRJ0_CANLF Zinc finger CCCH-type with G patch domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] ADTHKKMTE;DELRPFQDP;IELTEASLVSVRKSKLLA 3 7 0.99156 -0.54661 10.2282 0 0 0 0 0 0 0 0 0 0 0 0 7.78378 0 A0A8C0PRK9 A0A8C0PRK9_CANLF Coronin CORO1A Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cell migration [GO:0016477] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; phagocytic vesicle membrane [GO:0030670] actin filament binding [GO:0051015] AGPLLISLKDGYVPPKSRE;DTKHLEEPLSL;PDTIYSVDWSRDGALICTSCR 3 11.1 0.72997 0.25028 0 4.90804 0 0 0 0 0 9.55752 0 0 0 0 0 0 10.6045 A0A8C0PRM1 A0A8C0PRM1_CANLF Protein spinster homolog 1 (Spns1) Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] transmembrane transporter activity [GO:0022857] KRLRVPGLPSL;NSWHLPAG;VEISRRLRRSNPRAD 3 4.9 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 5.15628 0 0 0 0 A0A8C0PRM4 A0A8C0PRM4_CANLF Midkine (MK) MDK Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083]; heparin binding [GO:0008201] MQLRGFLLLALLTLL 1 17.2 0.98932 -0.26403 0 0 4.60128 0 0 0 0 8.63314 0 0 0 0 0 0 0 A0A8C0PRP1 A0A8C0PRP1_CANLF Transmembrane protein 252 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PCPTEGEVSDIP 1 7 0.9881 -0.26453 0 0 0 0 0 9.8697 0 0 0 0 0 0 0 0 0 A0A8C0PRP6 A0A8C0PRP6_CANLF Fibronectin type-II domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) single fertilization [GO:0007338]; sperm capacitation [GO:0048240] cell surface [GO:0009986]; extracellular region [GO:0005576] heparin binding [GO:0008201] EDGDAFGKKWCS 1 9.8 0.95315 0.05044 0 0 0 7.90165 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PRS2 A0A8C0PRS2_CANLF Centrosomal protein 131 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport involved in cilium assembly [GO:0035735] cilium [GO:0005929] KARQARRAAIQ;PVHGAQGAA;SEGVDLSLTGLPPPVSWRPN;SIMSFLHEMEM;TLLSEAKL 5 5.6 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 7.7998 0 A0A8C0PRS6 A0A8C0PRS6_CANLF ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cilium [GO:0005929]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] EFQKYIEE 1 4.7 0.21488 0.73358 0 0 10.6073 9.26875 0 0 0 0 0 0 10.6702 0 0 0 0 A0A8C0PRS8 A0A8C0PRS8_CANLF SAP domain-containing protein ACIN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] ADRNLKTEEEEEEEEEEEEEEEEE;AESEDEMIHPE;EGQENGQREEEEEEK;EIEPMEGPAPPVLTQ;EQEEERDRRETKRHSRSRSRSTPVR;ETESEKYVQPFPFKIEEL;GQENGQREEEEEEKE;IVHISNLVRPFTLGQ;QERAVREQWAEREREMERRERTRS 9 11.5 1.002 -0.6615 14.2248 0 7.77347 13.5242 4.78722 11.7714 0 0 0 15.468 8.66991 14.6655 14.5294 9.08202 0 A0A8C0PRT5 A0A8C0PRT5_CANLF Leukocyte immunoglobulin-like receptor subfamily A member 6 Canis lupus familiaris (Dog) (Canis familiaris) TSPYLLSHPSVPV;VGPVIPSLMWTFRCY 2 5.9 0.91736 0.11347 9.69765 0 0 0 0 7.83857 0 0 0 0 0 0 0 0 0 A0A8C0PRT9 A0A8C0PRT9_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IVSMAMREL;KVLHILPLV 2 5.6 0.9981 -0.60702 0 0 8.21476 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PRZ3 A0A8C0PRZ3_CANLF D(3) dopamine receptor (Dopamine D3 receptor) DRD3 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195] plasma membrane [GO:0005886]; synapse [GO:0045202] dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled receptor activity [GO:0004930] FGVTVLVYARIYVVLRQRRRKRIL;GVTVLVYARIYVVLRQRRRKRILT;LLFGFNTTGDPTVCSISNP;PLLSQLQPL 4 11.9 0.99427 -0.060888 0 11.9036 6.16167 0 0 0 0 0 5.19444 0 0 0 0 7.07553 0 A0A8C0PS09 A0A8C0PS09_CANLF 6-phosphofructo-2-kinase domain-containing protein PFKFB3 Canis lupus familiaris (Dog) (Canis familiaris) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524] QDHIQSRIVYYL 1 2.6 0.98947 -0.26329 0 0 0 0 0 0 0 0 0 0 8.81826 0 0 0 0 A0A8C0PS15 A0A8C0PS15_CANLF B30.2/SPRY domain-containing protein TRIM16 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GVEPDAVTLIHKFECRFSEPVYPAF;SRESALFQKDRYLEEENM 2 9.9 0.98931 -0.22677 0 11.8292 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PS28 A0A8C0PS28_CANLF Coiled-coil domain containing 116 Canis lupus familiaris (Dog) (Canis familiaris) QELVDGDSQSNEEEDEDQGE 1 3.1 0.9736 0.048206 0 0 0 0 0 0 6.81198 0 0 0 0 0 0 0 0 A0A8C0PS33 A0A8C0PS33_CANLF Coiled-coil domain containing 186 CCDC186 Canis lupus familiaris (Dog) (Canis familiaris) LEFEEHRKQ;SEQIASFPGGDFTKQVL;SEQIASFPGGDFTKQVLK 3 3.2 0.9863 -0.41658 14.1704 0 0 0 0 10.3463 0 0 0 0 0 0 0 11.3009 0 A0A8C0PS47 A0A8C0PS47_CANLF Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 NYAP2 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] GGTDDDNS;PSPVSMGRSLTPLSL;QAGASPSS;VGFLHLTMPEQRVCILGF 4 7 1.0037 -1.6039 0 0 0 0 0 7.8334 0 0 0 0 8.8489 5.57071 0 0 0 A0A8C0PS48 A0A8C0PS48_CANLF Uncharacterized protein CD247 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AAGGGGGG;WGGGGGGH 2 5.5 0.99008 -0.26592 0 8.83327 0 0 0 0 0 7.80594 8.67331 0 0 0 0 0 0 A0A8C0PS50 A0A8C0PS50_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2B2 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GKEGFNWDGTAVFPNSPPD;SLLVDNVKERATWFRTPH;VRDRTPAHSGGTGRSRD;VYTTVVEQLMLQKQRRFI 4 6.8 0.9974 -0.089543 0 10.6032 0 0 8.91689 0 4.7566 6.238 0 0 0 0 10.8744 5.85828 0 A0A8C0PS77 A0A8C0PS77_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] monoatomic ion channel activity [GO:0005216]; voltage-gated channel activity [GO:0022832] CREFLPQQVREGPG;QWILSFTIFLILF;WALWEAAAP 3 4.9 0.99057 -0.26875 0 0 0 0 0 0 0 0 0 0 0 0 0 7.53993 0 A0A8C0PS91 A0A8C0PS91_CANLF c-SKI SMAD4-binding domain-containing protein SKIL Canis lupus familiaris (Dog) (Canis familiaris) SMAD binding [GO:0046332] ELCSRLDPSIS;GSAFEVEHECLGKCQG;HAHRMEEFYIEQKDLEK;QSWYPVIKQEGDHVSQTHS 4 9.5 0.98696 -0.40694 0 0 0 0 0 8.28757 9.55148 5.67316 10.1 0 0 0 0 0 0 A0A8C0PSA2 A0A8C0PSA2_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AEARQNRQIDLQ;DHYFCHFCDSDGAQDYYSDYAYLRE;EARQNRQIDLQFSYAPR;FCHFCDSDGAQDYYSDY;HYFCHFCDSD;KGGRKGGP;PAGTWEVSGQ;TEGPAPARSTPKEP;YFCHFCDSDGAQDYYSDYAYLRE 9 8.2 1.0022 -1.4595 9.36429 0 5.43809 0 0 3.8214 9.89834 0 9.94479 8.74816 9.31956 0 9.29786 7.59701 9.55374 A0A8C0PSA5 A0A8C0PSA5_CANLF Prospero domain-containing protein PROX1 Canis lupus familiaris (Dog) (Canis familiaris) cell development [GO:0048468]; nervous system development [GO:0007399] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DMDRLCDEHLRAKR;DSTDSENDEDGNLSEDSMRSEIL;GTASAFFAKARATFFSAMNPQ 3 8.6 0.99479 -0.17366 0 0 0 0 9.86253 0 0 0 0 8.32742 0 11.28 0 0 0 A0A8C0PSA8 A0A8C0PSA8_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AEIQARRIAVDWESLGYNITRCH;AGILVFILLLLVVILIVKKS;AGILVFILLLLVVILIVKKSK;AGISAGILVFILLLLVVILIV;FILLLLVVILIVKK;FILLLLVVILIVKKSKLAK;GILVFILLLLVVILIVKKSK;GILVFILLLLVVILIVKKSKLA;ILLLLVVILIVKK;ILLLLVVILIVKKSKLAKK;ILVFILLLLVVILIVKKSKLA;ISAGILVFILLLLVVILIVKKSK;LDPNGVITQYEVSYSSI;LIVKKSKLAKKRK;LLLLVVILIVKKS;LLLLVVILIVKKSKL;LLLLVVILIVKKSKLA;LLLLVVILIVKKSKLAK;LLLLVVILIVKKSKLAKK;LLLVVILIVKKSKLA;LLLVVILIVKKSKLAKK;LLVVILIVKKSKLA;LLVVILIVKKSKLAKKRK;LLVVILIVKKSKLAKKRKDA;LVFILLLLVVILIVKKSK;LVFILLLLVVILIVKKSKLA;LVVILIVKKSKL;QVECMSCSMD;QVECMSCSMDC;SAGILVFILLLLVVILIVKKSK;SWTETHAVNAPTYKLWHL;TVSNLWNST;VECMSCSMDC;VECMSCSMDCDV;VFILLLLVVI;VFILLLLVVILIVKKSKLAK;VILIVKKSK;VINRIFRICNLTR;VLEDSQSFPGSYMIVDSSDHDPG;YHYFRGHNESK 40 11.3 0.97898 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 6.34303 0 A0A8C0PSD9 A0A8C0PSD9_CANLF Large ribosomal subunit protein eL39 (60S ribosomal protein L39) LOC100687764 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] KTFRIKRFLAKKQKQNRPIPQWIW 1 47.1 0.97344 0.041303 0 0 0 0 0 0 0 0 6.28947 0 0 0 0 0 0 A0A8C0PSE9 A0A8C0PSE9_CANLF SEFIR domain-containing protein IL17RA Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] APGRLLLALLLSPLAPAR;QEGLNCTVKNSTCLDDS 2 4.2 0.92877 0.09454 0 0 0 0 0 0 0 0 0 0 0 5.46793 5.98048 0 0 A0A8C0PSF1 A0A8C0PSF1_CANLF HTH TFE/IIEalpha-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase II promoter [GO:0006367] DDDEEEEDEFEEVAD;EEEEDEFEEVADDPI;TQNVVINMDDQED 3 7.4 0.85487 0.16739 0 5.25493 0 0 0 0 0 0 0 0 5.31208 0 11.0637 0 0 A0A8C0PSF2 A0A8C0PSF2_CANLF Beta-lactamase-related domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VLRLQRKPALQA 1 2.4 0.94185 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 3.65638 0 A0A8C0PSG4 A0A8C0PSG4_CANLF Cholinergic receptor nicotinic beta 2 subunit Canis lupus familiaris (Dog) (Canis familiaris) neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] ARQRLRLRRRQREREA;VLLALTVFLLLISKIVPPTSLDV;WNWGLTHSTGSPAIH 3 11 0.94082 0.10313 0 0 0 0 0 0 0 8.00304 0 0 0 0 0 0 0 A0A8C0PSG6 A0A8C0PSG6_CANLF SEC7 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] CCLILLYLSVI;GQMRHSFSAGPELLRQEKR;SITSAHSSS;SSQQCSSEDED;STESESRKRSISKR;TNYIQMHL 6 3.4 1.0029 -0.85623 0 0 0 6.65578 0 0 10.0852 7.13473 0 0 0 9.8958 0 0 0 A0A8C0PSH3 A0A8C0PSH3_CANLF Charged multivesicular body protein 6 CHMP6 Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; vesicle budding from membrane [GO:0006900] ESCRT III complex [GO:0000815]; multivesicular body [GO:0005771] EQLLDKTENQISSLE;KLLLKKKRY;KMHQVMSIEEVERI;QIGNECLKKMHQ 4 22.9 1.0043 -1.0926 0 10.2555 0 0 8.71771 0 0 0 11.6453 0 0 0 0 8.78647 0 A0A8C0PSI3 A0A8C0PSI3_CANLF Thioredoxin domain-containing protein 17 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] protein-disulfide reductase (NAD(P)H) activity [GO:0047134] LVESECLQANLV;RCGCQVQMAGCEEVSVSGFEE 2 15.6 0.98956 -0.21926 8.33682 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PSJ3 A0A8C0PSJ3_CANLF T-box transcription factor 4 TBX4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AADSDPEPERL;ASPLGAGH;DPAPAREPPASPGS;FPMSAFLAAAQP;GGGGGGGG;GGGGGGPG;SRSHFLGSA 7 9.5 1.0033 -2.0951 7.4591 0 0 0 0 10.3848 7.26369 0 8.1015 10.4267 0 0 9.77243 0 0 A0A8C0PSK5 A0A8C0PSK5_CANLF tRNA wybutosine-synthesizing protein 3 homolog (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; tRNA processing [GO:0008033] methyltransferase activity [GO:0008168] EENKKRIE;QLQDAQILHSVAI 2 8.1 0.98945 -0.20227 0 11.0545 0 0 9.7178 0 0 0 0 0 0 0 0 0 0 A0A8C0PSN9 A0A8C0PSN9_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] plasma membrane [GO:0005886] thrombin-activated receptor activity [GO:0015057] RMRSVRAARLLGVAVLLAAAVP 1 3.6 0.97785 0.04742 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.49793 A0A8C0PSP1 A0A8C0PSP1_CANLF Photolyase/cryptochrome alpha/beta domain-containing protein CRY2 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide binding [GO:0000166]; photoreceptor activity [GO:0009881] GVPSLEELGFPTEGL 1 2.8 0.98783 -0.22714 0 0 0 0 0 0 0 0 0 0 0 0 9.56029 0 0 A0A8C0PSS4 A0A8C0PSS4_CANLF G-protein coupled receptors family 1 profile domain-containing protein CCR6 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935]; immune response [GO:0006955] membrane [GO:0016020] C-C chemokine receptor activity [GO:0016493] RLRSRTLAH 1 2.4 1.0045 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.80181 A0A8C0PST4 A0A8C0PST4_CANLF Protein maelstrom homolog Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulatory ncRNA-mediated gene silencing [GO:0031047] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677] AMWDYSSNTRC;KEEEKEKYA;YFFVQEKIPELRR 3 7.6 0.98726 -0.46325 0 11.7495 0 0 0 0 0 0 8.95297 0 0 0 0 0 0 A0A8C0PSV9 A0A8C0PSV9_CANLF Dermatan sulfate epimerase like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CFKTQKVQDFKPN;ICAKWARTEAEASLKSLSSEG;NNVLVFAPSPTSQ;RFYLSFRKLMRWILILVIALWFIE;VGYKDWLVENAPGDEVP 5 9.7 0.94204 0.059729 0 0 0 0 0 0 0 0 0 9.2134 0 0 0 9.42042 0 A0A8C0PSX0 A0A8C0PSX0_CANLF Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] FIVDVKAEAKAKALKAKKAVLK;LKAKKAVLKGVHSHKKKKILTSP;PRRNKFDHYA 3 28.9 0.98741 -0.47818 0 6.64061 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PSX9 A0A8C0PSX9_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC16A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] YDWTQTYDTAFYFSGFFFVLAPSK 1 5 0.974 0.041303 0 0 0 0 0 0 0 9.80901 0 0 0 0 0 0 0 A0A8C0PSY8 A0A8C0PSY8_CANLF Lysine-specific demethylase (EC 1.14.11.65) JMJD1C Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] DCKSPTHLTVSSTNALRSMPAL;DKQLDFLTEDSAFQPYQDDIDSLNP;EQHILWLKDYKNINNWKLFKECWKH;GVIRAVSHRDSRNPDLAVYVE;KCRECRLIRSKKGEEPAHSPV;MKHSVPQSLPQ;QEIFMQGP;QESIDVAPFTT;SEIPGALWHIYAGKD;VLPEHDPIRD 11 7.2 1.003 -2.4607 11.5613 0 0 0 0 0 10.7844 0 10.5387 0 0 10.4372 7.5678 9.6517 0 A0A8C0PSZ9 A0A8C0PSZ9_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP9B Canis lupus familiaris (Dog) (Canis familiaris) "endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endosome [GO:0005768]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] KAAYGWMIMKDE;LAADFSITQFKH;VRTSTIPEELGRLVY 3 3.6 0.99182 -0.1811 0 0 0 0 0 0 0 0 0 0 5.37528 0 0 10.4481 0 A0A8C0PT00 A0A8C0PT00_CANLF CBM21 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALTLPVLERLKLLKKK;ASALTLPVLERLKLLKKKKKKK;ERLKLLKKKKKK;LERLKLLKKKK;LERLKLLKKKKKKKSPS;LKLLKKKKKKK;LPVLERLKLLKKKK;LPVLERLKLLKKKKKKK;LTLPVLERLKLLK;LTLPVLERLKLLKKKKK;LTLPVLERLKLLKKKKKK;RLKLLKKKKK;RLKLLKKKKKK;RLKLLKKKKKKK;RLKLLKKKKKKKS;RLKLLKKKKKKKSP;VLERLKLLKKKKKKK 17 5 0.98942 -0.52996 0 5.09837 7.49849 0 5.66195 5.96211 7.03705 5.9419 6.40402 11.2498 7.2485 6.21093 5.97643 5.03122 5.90872 A0A8C0PT11 A0A8C0PT11_CANLF Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) CDK20 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EIKALQEIEDNQ;ESGRPEKDFICKAIAG;IVALKKVALRRL;LGTQTWKEYYLCR;TEIWSSPLQ;VYVWNKEN 6 9.7 0.98501 -0.44544 0 0 5.9222 8.17677 5.25524 5.59491 0 8.31515 10.1454 0 7.24165 6.31168 7.61405 10.1286 0 A0A8C0PT13 A0A8C0PT13_CANLF Myelin basic protein MBP Canis lupus familiaris (Dog) (Canis familiaris) myelin sheath [GO:0043209] structural constituent of myelin sheath [GO:0019911] LKIPLIKPLLPTRLACA;QQRRRPGV 2 6.9 0.98936 -0.21466 0 3.94982 0 10.6137 0 0 5.54458 0 0 0 3.86651 0 4.84995 0 3.97085 A0A8C0PT17 A0A8C0PT17_CANLF CAP-Gly domain-containing protein CLIP1 Canis lupus familiaris (Dog) (Canis familiaris) HVLELEAKMDQLRT;LAKDKDEIIQKL;LQEMVELKKQ;MEEFRKEIETL;TDSECIQLLHEKE 5 2.9 1.0032 -1.0305 0 9.21381 11.132 0 0 4.72252 0 0 12.5809 0 0 0 9.28411 12.0133 0 A0A8C0PT21 A0A8C0PT21_CANLF Glia maturation factor beta GMFB Canis lupus familiaris (Dog) (Canis familiaris) actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; vesicle-mediated transport [GO:0016192] actin cortical patch [GO:0030479]; membrane [GO:0016020] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933] EKVKKIKRVKIALK;EKVKKIKRVKIALKLVLP;KKIKRVKIALKLVL;KKIKRVKIALKLVLPE;KVKKIKRVKIAL;KVKKIKRVKIALK;KVKKIKRVKIALKL;KVKKIKRVKIALKLV;KVKKIKRVKIALKLVL;KVKKIKRVKIALKLVLPE;KVKKIKRVKIALKLVLPEYL;SYKYQHDDGRVSYPLCFIFS;TLGLNMPLLAYHIWSM;TVEKVKKIKRVKIALKLVLP;VEKLRKFRFR;VEKLRKFRFRK;VEKVKKIKRVKIALKL;VEKVKKIKRVKIALKLVLP;VEKVKKIKRVKIALKLVLPEYLI 19 34.6 0.725 0.26001 2.24092 7.54736 8.73806 4.23749 0 6.43107 2.60592 8.09766 7.58406 0 4.74233 8.38124 0 4.06376 7.65399 A0A8C0PT25 A0A8C0PT25_CANLF Voltage-dependent R-type calcium channel subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268] neuronal cell body [GO:0043025]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331] ADASDEVGMLPASPRAAAS;DEGVLTDGEKEREP;DEQEEEEAFNQKH;DFAISAKPLTRYMPQ;DHEKNKMEVKGREWKRHEFH;DPADDGQF;GGHAGKEPTIQEED;GVDNFFPVQEGEGA;HYRRRRRGGPGP;IKSLRVLRVLRPLKTIKRLPKL;ISVLRALRLLRI;ISVLRALRLLRIF;IVHHNQPQWLTHLLYY;LRVLRVLRPLKTIKRLP;PQQCSLLE;RPLKTIKRLPKLKA;RVLRVLRPLKTIKRLPKL;SRRRSYHSSL;SYLRNGWNVM;TIKSLRVLRVLRPLKTIK;VENRRAFMKLRRQQQI;VISQSEPDLSCVT;VLRALRLLRIFKI;VLRPLKTIKRLPKLK;VLRVLRPLKTIKRLP;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKA;VLRVLRPLKTIKRLPKLKAVF 28 10 0.99822 -3.3013 0 8.27882 0 8.90213 10.0913 8.43983 0 11.4324 0 0 9.57818 0 0 9.15325 0 A0A8C0PT28 A0A8C0PT28_CANLF Solute carrier family 41 member SLC41A3 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion transport [GO:0015693] membrane [GO:0016020] inorganic cation transmembrane transporter activity [GO:0022890]; monoatomic cation transmembrane transporter activity [GO:0008324] GAGSATYP;LVCIGFMALIPMWV;SALSLGEPDLRVTPASALCGPGR 3 5.7 0.99274 -0.28203 4.55557 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PT70 A0A8C0PT70_CANLF FA core complex associated protein 100 Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] GVAPDGTEVHLT;PQNMSVWDLGWVHFCG;PSGTSALPLCSCQGHQL;QTLRDRLCTEDEASSCTT;VQTLRDRLCTEDE;VTLPLGPGEDGA 6 14.4 0.98688 -0.40717 0 0 0 9.06477 0 0 0 11.6239 0 6.86728 0 0 0 0 0 A0A8C0PT73 A0A8C0PT73_CANLF "CRK like proto-oncogene, adaptor protein" Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell motility [GO:2000145]; regulation of intracellular signal transduction [GO:1902531] TRMNINGQ 1 2.9 1.0044 -1.1044 5.42804 5.33024 0 0 0 0 0 5.47505 0 0 5.69977 5.25833 0 10.6684 0 A0A8C0PT75 A0A8C0PT75_CANLF Protein phosphatase 1 regulatory subunit 26 PPP1R26 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase inhibitor activity [GO:0004864] ALGMSDELALQRSQRAEK;DSSELSDTSMEEG;EQEIRTFL;KKRWKDPRAACKRKVR;LELSDQQGAP;LVCTHKDQSSRGTECARQRAL 6 7.3 1.0018 -0.66315 9.55695 7.83763 0 0 8.73491 0 0 9.38398 0 0 0 0 11.1438 0 0 A0A8C0PT77 A0A8C0PT77_CANLF Rae1 protein homolog (mRNA-associated protein mrnp 41) RAE1 Canis lupus familiaris (Dog) (Canis familiaris) RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] nuclear pore [GO:0005643]; spindle pole [GO:0000922] RNA binding [GO:0003723]; ubiquitin binding [GO:0043130] QPSEFRRIE;QPSEFRRIESP 2 3.3 0.99376 -0.16452 9.4685 0 0 0 0 0 0 10.2776 0 0 13.193 0 0 0 0 A0A8C0PT83 A0A8C0PT83_CANLF Active breakpoint cluster region-related protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] axon [GO:0030424]; dendritic spine [GO:0043197] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DESPTMSPQLS;DGFLVEVS;DSFGYFVSKAKTRVFRDTTEP;GLPRLSWIDTL;HSAKGFKQSANLY;VLSGFLASEEI 6 8.7 1.0023 -1.8744 0 4.00648 0 0 0 0 0 0 0 0 0 10.8265 0 11.9321 0 A0A8C0PT87 A0A8C0PT87_CANLF Mannose receptor C-type 1 MRC1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] ALGGDLASINNKE;AYLTTIEDRYEQAFL;CKEGWHFYNNKC;DDENCVTMYSNSG;ERYFWTGLSDVQNKGTFQWTIE;IEEKVLFTHWNSDM;IITADRVQE;KLFGYCPLKFEGSESLWNKDPLTG;NWNTGDPSGERNDCV;RSDEIPATEPP;SEFQKWECKNDTLLGIKGEDLFFN 11 11.7 0.98446 -0.24613 0 9.67188 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PT92 A0A8C0PT92_CANLF Electron transfer flavoprotein subunit beta CLDND2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrial matrix [GO:0005759] electron transfer activity [GO:0009055] TTTNSHFGTCFPVV;VRLKLPAVVTADLRLNEPRYATL 2 8.7 0.99092 -0.21011 0 0 0 0 0 0 0 0 0 9.48675 0 0 0 0 0 A0A8C0PT94 A0A8C0PT94_CANLF VTT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of bone resorption [GO:0045780]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of cytosolic calcium ion concentration [GO:0051480] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] AAGGGGGG;AAWVAARIQSSGR;ALPRLLPPAVL;GGGGGGGA;GGGGGGGG;LPPAVLPGLPGL 6 11.4 0.98606 -0.41702 14.0631 7.88686 0 0 0 0 0 0 0 0 0 0 0 9.34201 0 A0A8C0PT97 A0A8C0PT97_CANLF Poly(A) binding protein nuclear 1 PABPN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] poly(A) binding [GO:0008143] MAAAAAAAAAAGAAGGRGS;RVREMEEEAEKLKELQNEV 2 12.5 0.93513 0.099847 0 9.35647 0 0 0 0 0 0 0 0 0 0 9.09521 0 0 A0A8C0PTD6 A0A8C0PTD6_CANLF ISL LIM homeobox 2 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CRADHGLLLERAAAGSPHSPGP;EKTTRVRTVLNE;EKTTRVRTVLNEKQLHTLR;EVQTYQPPWKAL;GSPGRGRWGPPGAEG 5 17 0.99026 -0.20193 0 0 0 0 0 0 0 0 10.2378 0 0 0 0 0 0 A0A8C0PTE6 A0A8C0PTE6_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] VGFLLPPV;VGGGPSAP;VLGFFMTGYLPLGFEF;YSLVNAFQWIQYSI 4 7.1 1.0023 -1.3011 0 0 11.2935 0 0 0 0 8.98704 0 0 0 0 0 0 0 A0A8C0PTG1 A0A8C0PTG1_CANLF Vesicle transport protein TBX19 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] VLSGQDTEDRGGLAEVVEA 1 17.6 0.94994 0.049735 0 0 0 0 0 0 0 0 9.3656 0 0 0 0 0 0 A0A8C0PTG5 A0A8C0PTG5_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gamete generation [GO:0007276] nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] FDPESDNHLAQPLV;TLNTAGFSSSQAPNPVDDES 2 6.3 0.91247 0.11076 0 0 0 0 0 0 0 10.289 0 0 0 0 0 0 0 A0A8C0PTH0 A0A8C0PTH0_CANLF GRB2 related adaptor protein GRAP Canis lupus familiaris (Dog) (Canis familiaris) regulation of MAPK cascade [GO:0043408]; signal transduction [GO:0007165] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784] DDQNWYKAEL;LNELVDFYRTTTIAK;SDALGVPAINSGHLSLDRAG 3 13.6 0.99154 -0.13334 0 10.3838 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PTH4 A0A8C0PTH4_CANLF C-type lectin domain-containing protein CLEC14A Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477] external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012] extracellular matrix binding [GO:0050840]; extracellular matrix protein binding [GO:1990430] RGFSWLSPD;SAALDFSPPGTQVSALCPGQL 2 6.1 0.98791 -0.26465 0 0 0 0 0 0 0 0 0 0 6.22029 0 0 0 0 A0A8C0PTI8 A0A8C0PTI8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLFTTALTLLFLLEI;TFLCWIRRFRLVRKG 2 27.3 0.93173 0.10775 0 0 0 0 0 0 0 0 0 0 0 8.72772 0 0 6.75462 A0A8C0PTQ1 A0A8C0PTQ1_CANLF BCAS3 microtubule associated cell migration factor BCAS3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; response to starvation [GO:0042594] cytoplasm [GO:0005737]; membrane [GO:0016020] PGSPGPIT;VHIYVCVCLRF;VHIYVCVCLRFI 3 2.3 1.0037 -0.80335 0 10.12 0 0 0 0 0 10.6869 0 0 0 0 0 0 0 A0A8C0PTS5 A0A8C0PTS5_CANLF rRNA adenine N(6)-methyltransferase (EC 2.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] "RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" DKRARSMDIDDF 1 4.1 0.94221 0.05044 0 0 0 0 0 0 8.69648 0 0 0 0 0 0 0 0 A0A8C0PTS6 A0A8C0PTS6_CANLF Nuclear receptor coactivator 7 NCOA7 Canis lupus familiaris (Dog) (Canis familiaris) DDEMALPILQPHSALLE;FSPNFKVFKWSGENSY;IVQDLEVRDQRTEF;VGGVMIVTPNNIMFDP;VPRERVDH 5 7.4 1.0032 -1.027 0 0 0 4.82843 0 0 0 10.0282 0 0 0 0 0 11.5752 0 A0A8C0PTU6 A0A8C0PTU6_CANLF phosphatidate phosphatase (EC 3.1.3.4) Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] AFGNRPNDVYAY;APLVKSGGNERPSQSSDISH;DFMLLPPKLPT;HKRSQHQGPDDIYLDDLKALEPEV;MPKKSGRWWFW;SITTQYQGTCRC;TCRCAGTIYLWN;VKKKKRRRKKCK;YYNWALAAPMILSLQVFQKS 9 13.8 0.99411 -0.13135 10.9131 0 0 0 0 0 7.88222 10.6982 6.2151 4.9389 0 3.16689 7.90563 8.47115 0 A0A8C0PTU7 A0A8C0PTU7_CANLF Claudin Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] WTTNDVVQNFYNPL 1 6.1 0.94167 0.061082 0 0 0 0 0 0 4.97444 0 0 0 0 0 0 9.51783 0 A0A8C0PTU9 A0A8C0PTU9_CANLF Solute carrier family 44 member 5 SLC44A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] organic cation transmembrane transporter activity [GO:0015101] APESPGLP;DGSTERPYYMSQS;FIFISICIAYW;FSCTSPSVVVNLQCPT;GKILVAGCI;LENVIKYFNR 6 7 1.0029 -2.5044 0 0 0 0 0 0 0 0 10.1805 0 0 8.69387 0 6.54978 7.76937 A0A8C0PTV3 A0A8C0PTV3_CANLF Kinesin-like protein KIF25 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] LCPRCLEQDPP;MPRAAAELFRYL;VLCFVLSNM;VLSNMCFSL 4 6 1.0031 -0.97667 10.9083 0 7.37539 0 8.35918 0 0 0 0 0 0 0 0 13.8616 0 A0A8C0PTX1 A0A8C0PTX1_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ASAIPVSTQLDIAAQHHL;FAASVGSPKRKQ;GLLGPTTLSL;LSLNTSTSPNSL;NRNNQAEKSNQ;PSSGTPSPTLWAPPLA;PWRRRRRRRRRPGDE;VIVKSVERNALNM;WSGLGFSKSMPAET 9 11.7 1.0023 -1.1707 0 0 0 6.87172 6.23226 0 0 3.73064 0 0 8.69804 0 13.8881 0 12.572 A0A8C0PTX9 A0A8C0PTX9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NVHTVMLIVNYQFL 1 24.6 0.99011 -0.21362 0 0 0 0 0 0 0 13.3509 0 10.7254 0 0 0 0 0 A0A8C0PTY5 A0A8C0PTY5_CANLF Nucleolar GTP-binding protein 1 GTPBP4 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] GTP binding [GO:0005525] DFIDLTLSKTQRKTPTVVHK;DRNTIEMQAITALAHLRAAVL;IRQLAKQIREKKKLKILQ;LEQVRQHLSRLPTI 4 11.9 0.93544 0.097973 0 0 12.8043 0 0 0 0 5.61265 0 0 4.2121 0 0 0 6.95338 A0A8C0PTY6 A0A8C0PTY6_CANLF "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" UBR4 Canis lupus familiaris (Dog) (Canis familiaris) proline catabolic process to glutamate [GO:0010133] mitochondrial matrix [GO:0005759] 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842] ETHEPLGDW;LLPLPPALRRALLARPWRDP;VVGDEEVWTLDVQYQV 3 8.8 1.0011 -0.70678 8.33802 0 0 0 0 0 0 3.91724 0 0 0 3.99774 10.2048 3.35516 10.1634 A0A8C0PTY7 A0A8C0PTY7_CANLF N-sulfoglucosamine sulfohydrolase SGSH Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] HQNGMYGLHQD;NLAADPYYAPVLELLQ;SLPLLLGRAGVRTGIIGKK;TSDNGIPFPSGR;VLEEKLSPQCRPLHNEL 5 15.8 0.99685 -0.59093 0 0 0 0 0 12.7048 0 0 0 9.04467 0 0 0 0 10.2812 A0A8C0PTZ5 A0A8C0PTZ5_CANLF Superkiller complex protein 8 (WD repeat-containing protein 61) LOC100687895 Canis lupus familiaris (Dog) (Canis familiaris) SLDDLVKVWKWCD;TLEGRAMPICSLTFS 2 9.9 0.99139 -0.18131 0 0 0 0 0 0 0 9.22139 0 0 0 0 0 0 0 A0A8C0PU01 A0A8C0PU01_CANLF Interleukin 6 cytokine family signal transducer IL6ST Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] IFFTTESVGELLDP;LDSEERPEDLQLSAFTYMVLVRWG;LSAFTYMVL;METRALEIESLLTLCNKR;TASTRYSFTVQDLKPFTEYV;TDVSVVEI 6 9.7 1.0032 -1.7328 9.5254 9.68853 0 0 0 0 0 11.2539 0 0 0 0 0 0 8.85197 A0A8C0PU04 A0A8C0PU04_CANLF Huntingtin interacting protein 1 related Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] cytoplasm [GO:0005737] actin binding [GO:0003779]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] EFYAKNSRWTEGL;HDRYGQLVNVY;LDDPLHLRCTSSPDYLV;QEKEEALSREQQRSSQERA;VYTKLLLTKI 5 6.4 1.0037 -0.83051 0 0 0 0 0 0 0 0 0 9.60379 0 0 0 6.05652 0 A0A8C0PU05 A0A8C0PU05_CANLF N-acetyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) peptide alpha-N-acetyltransferase activity [GO:0004596] GAAAAAAKGHP;GSGETQERGGRASLG;GVHSGESPPHCLP;PGVRSSAGGAAAAAAKGHPCLRCPQ;SLRSPSGREVE 5 16.1 0.98592 -0.41274 0 0 0 0 0 0 0 6.32481 0 0 0 9.89028 0 0 0 A0A8C0PU20 A0A8C0PU20_CANLF ENTH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794] DEPDSSSSS;ERVAASEWSPLGV;FAGNQAFLQPLSSTL;GPHLPAGMGSQSRPQGSLQ;KLKVLKILLHL;LKVLKILLHL 6 11.2 1.0031 -0.83883 0 9.38202 9.25425 0 0 0 8.53823 11.3215 0 0 9.79633 9.83021 0 0 0 A0A8C0PU35 A0A8C0PU35_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEHHLRDY;FGGGCGGG;GCGGGFGG;GGGCGGGF;SGSGNFGG 5 8.1 0.99717 -3.5791 0 12.1359 12.1638 0 0 11.1643 0 0 0 0 12.015 11.9591 0 0 12.0588 A0A8C0PU38 A0A8C0PU38_CANLF Ring finger protein 213 RNF213 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] DLFLDGVSLRKT;EKHYLDINTVLE;GKPRITLMGIPTL;GLSKKLVEIF;ICMETGKMVVLLNLQ;KLHETICSITKDE;LALGDWHQ;LEELWVQAQYITGAE;LGDWHQYDDMVRM;LLREENMLSQMDRYL;LLTHLALL;NLSRILTIYPQILQVL;PEDLLVQARNWKGLET;PLEGAGPPG;PYIMVHNDMSP;SLDAIHPSSGRVI;TYSMWCSPEP;VEYLQEMTRIRLCLNKAS;VIMDGVRDEDLAPFSLRK;VLDRDSNLE;VLHMALWSCINQLHTQRP;VLKLLLKYR;VLPAALAIYRHM;VMHTLCKCKEQAS;VPLKVIRLI;WHAWEPASFQEV;YSMWCSPEPASEA;YTAEQLVYLSTQLKEQKP 28 6.8 0.99721 -0.59284 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.187 A0A8C0PU64 A0A8C0PU64_CANLF Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249] DKIPDAATRAFW;FSSYFVYLAE 2 3.1 0.99128 0.012894 10.3127 0 0 10.127 0 0 10.2883 0 10.0938 0 0 0 0 0 0 A0A8C0PU83 A0A8C0PU83_CANLF Uroplakin 1A UPK1A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RPVQLSGLALFAETVWVTADQ 1 6.7 0.97829 0.047591 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.16269 A0A8C0PU84 A0A8C0PU84_CANLF Large ribosomal subunit protein eL42 (60S ribosomal protein L36a) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] DSLYAQGKRRY;RKKAKTTKKIVL 2 7.7 0.94414 0.05044 0 0 0 6.27055 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUB2 A0A8C0PUB2_CANLF Cyclic AMP-dependent transcription factor ATF-7 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGIFADKLAAAAGPLD 1 3.2 0.95646 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.2275 A0A8C0PUB4 A0A8C0PUB4_CANLF SH3 domain-containing protein MIA2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] AGEDGNDLEELNNDKHQTEQKQE;DASFEKESTEAQSL;ESTWFEDQFPASEAP;EVQISTKESDFLCLLGVSYSF;FFPPPPHP;FPGPPHPP;GPMSSEVETSRNDSKDD;GVSYSFENEDSEL;LDTKGSTEA;LEDEILFLEN;LLFLWRSFQSVRSRL;QENEMTLH 12 11.1 0.99961 -2.854 8.08821 0 0 7.64234 7.64818 0 0 9.70817 0 0 0 13.7177 11.047 0 0 A0A8C0PUC3 A0A8C0PUC3_CANLF EMAP like 1 Canis lupus familiaris (Dog) (Canis familiaris) CCLFTYPS;DELWGLAIHASKPQ;GGGGGGGG;GGGGGGPG;GGGGGGSG;GTLVSGGG;GVPPRAVRPG;RGCGGGGGG;VGVSGGGG;YFWTLEGN 10 6.9 0.99685 -4.1593 10.7474 8.78869 0 0 0 14.9557 13.5093 4.65512 0 0 0 0 0 0 10.5364 A0A8C0PUD3 A0A8C0PUD3_CANLF Beta-secretase 1 (EC 3.4.23.46) (Beta-site amyloid precursor protein cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) BACE1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037] aspartic-type endopeptidase activity [GO:0004190] EAAVKSIKAASSTEKFPDGFW;EINGQDLKMDCKEYNYD;EPRGPQGQ;QPPADAVSRRR;RCSGVGAVSSAARLRVALRLL;TVRANIAAITES;VGAAPHPFLHRYYQ 7 17.3 1.0041 -1.0983 0 0 0 7.95629 0 0 7.59679 0 0 0 0 9.89207 0 9.99039 5.54939 A0A8C0PUE0 A0A8C0PUE0_CANLF Family with sequence similarity 120A Canis lupus familiaris (Dog) (Canis familiaris) GGGAAANH;HSQAPQVPSPGAAGQGPHPYSLAE;RPGRATAP;VLRYMVQWPGAR;YYGRGYKNQ 5 5.5 1.0032 -2.4126 0 0 0 0 7.79435 0 0 9.58222 10.2357 0 0 7.83093 0 0 0 A0A8C0PUF1 A0A8C0PUF1_CANLF Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DUSP29 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein tyrosine/serine/threonine phosphatase activity [GO:0008138] PTFDLSVFFYPAAAFI 1 7.3 0.98948 -0.21715 9.47648 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUF9 A0A8C0PUF9_CANLF Importin N-terminal domain-containing protein IPO11 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] cytoplasm [GO:0005737] small GTPase binding [GO:0031267] CVIERVNIQIRPYVGCLVQYLP;PHKNMEVMLLDF;QHRALLTFYHVTK;SHYFLLTEEELT;VLSCVIERVNIQ 5 6.6 1.0021 -1.0141 0 9.21638 0 0 0 8.3443 9.52225 0 0 0 0 0 0 0 9.25352 A0A8C0PUH2 A0A8C0PUH2_CANLF CAP-Gly domain-containing protein CEP350 Canis lupus familiaris (Dog) (Canis familiaris) microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] DIQEQKNIKERDLS;DLSLLENLFAPKEIPYSVD;EKIEWLDSLTGNV;GVGNLSEFKKLPEMIRPH;HCSPVHYFFSV;IENLHRKELKE;QLERVSLLTD;SEEKKSEQQLERV;SRELYRDLALHFADDI;TASGAPLA;TSNSQRLDIL;VISKKRHYDTDEV;VISKKRHYDTDEVRQ;VLGDDQDWFD;VQELHEEEAQWV;VRQYIVRQ 16 5.7 0.99728 -3.7869 10.8803 5.73151 9.11975 0 9.95262 5.00013 0 14.1959 0 9.19242 13.4694 10.32 9.86085 13.6639 6.24542 A0A8C0PUH3 A0A8C0PUH3_CANLF M-phase phosphoprotein 9 MPHOSPH9 Canis lupus familiaris (Dog) (Canis familiaris) DEGKIFKNWGTQTEKEDTSNK;DLVKSLRKTSCSV;LVKLQTSNASWASYDT;PVEKSNFT 4 5.1 0.98917 -0.30726 11.3018 0 0 0 0 0 0 0 0 0 0 7.08204 11.6831 0 0 A0A8C0PUJ7 A0A8C0PUJ7_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; transferase activity [GO:0016740] FLPAGAGN;KSSQATSHRHSM;LWSDLGSRS;MAAIRPEPKP;PYGKALYSYEGKEPGDLKFS;QLMEMDKPCPAAVSGCHA;SEGDDDRPGE;TLQRNGRTGLF 8 10.4 1.0024 -2.587 11.817 10.5541 11.7434 0 10.1285 5.86047 0 13.0011 13.1043 12.1487 0 7.58526 12.7633 12.1774 12.9354 A0A8C0PUJ8 A0A8C0PUJ8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAGGAAQP;DPSLQPELWAGAGGG;GAGGGGGG;GGGGGGGG;KAGSGPGA;PALAATVF;PGGGGGGK;PPPRRPRPRVRRGL;RSFLRGARTRSG;TVFFCLGQTTRPRSWCLRLVCNP 10 17.2 1.0045 -2.0098 0 0 10.1054 9.85003 9.41969 11.4285 0 0 0 8.01586 9.27114 0 12.9705 0 10.9707 A0A8C0PUL7 A0A8C0PUL7_CANLF ERCC4 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] Holliday junction resolvase complex [GO:0048476]; nucleus [GO:0005634] DNA binding [GO:0003677]; nuclease activity [GO:0004518] GAGGAGRS;PLLIPVPALGIH 2 5.4 0.95512 0.05044 0 0 0 4.34127 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUM7 A0A8C0PUM7_CANLF Meiosis regulator and mRNA stability factor 1 (Limkain-b1) Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] peroxisome [GO:0005777] RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] ELTPHLCTNSL;ESKTGTRNSDSQQ;GAANKSLSLLR;GGGGGGGG;GGGGGGSG;HFGGGGGGG;KSSSAIAD;LRFINQDSAERA;NCGGKVLSITGC;PPHRSSSAT;QLFLHEFSMAYTKYV;SCCAHCPNE;SEHEFDPD;SLGKASSKFGSPEV;VGETLQPKTYGYSSVE 15 9.1 0.99663 -4.8324 12.7764 0 0 5.8583 8.83826 0 5.33614 0 0 0 0 0 0 0 4.88606 A0A8C0PUM9 A0A8C0PUM9_CANLF Ion transport domain-containing protein CACNA1H Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] AEGDANRSDTDEDKTSTHLEED;CINWNQYYNVCR;DTRNISTKAECR;EPYKPAWCRSR;GAKILGILRVLRLLRTLRPL;GILRVLRLLRTLRPLRVI;GVAPEPRASFS;ILGILRVLRLLRTLRPLRVISRAP;ILRVLRLLRTLRPLRVI;KILGILRVLRLLRTLR;KILGILRVLRLLRTLRPLR;LGILRVLRLLRT;LSVLRTFRLLRVLKLVRFM;PNFAFEPPDKG;RGLHLRVL;RLLRVLKLVRFM;RVLRLLRTLRPLRVISRAPGLKL;SNDSTLASFSE;SVHSVYHAD;VLRLLRTLRPLRVISRAPGLK;VPVGALQHPGG 21 7.4 0.98876 -0.26069 9.54241 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUN4 A0A8C0PUN4_CANLF Hepatocyte growth factor-regulated tyrosine kinase substrate HGS Canis lupus familiaris (Dog) (Canis familiaris) membrane invagination [GO:0010324]; negative regulation of angiogenesis [GO:0016525]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; protein localization to membrane [GO:0072657]; protein targeting to lysosome [GO:0006622] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; lysosome [GO:0005764] metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; ubiquitin binding [GO:0043130]; ubiquitin-like protein ligase binding [GO:0044389] LMTTLPSQDAPLP;LNRNYWEKKQEE;LSQSEAEEKERMRQ;MRAQMPAFSLPYAQLQAMPPAGGVL;NDSAVLSLFQSIN;PAGRPLGDQLRPRGQAP;PAGSVEGS;PVEGHAVPANALETPLPE;RASPRAKYAVSSIKK;RGPQQQTHRAPAPA;TELPPEYLTSPLSQ;TTELPPEYLTSPLSQQ;VLYQPSGPTSFPGTFSPAGS 13 17.6 1.0023 -1.2383 0 12.3268 0 0 0 9.99506 12.0506 0 12.1903 0 11.1734 0 0 10.4797 0 A0A8C0PUQ3 A0A8C0PUQ3_CANLF Adenosine deaminase RNA specific B1 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] ACSAVRTGQACC;LSQTGPVHAPLFVMSV;SGDLSLAASPAPA;VGDAAIEVINATTGKD 4 7.7 0.99373 -0.025882 0 5.60647 13.9858 0 0 0 0 8.67175 0 0 0 13.991 0 0 0 A0A8C0PUR6 A0A8C0PUR6_CANLF FXYD domain-containing ion transport regulator Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] sodium channel regulator activity [GO:0017080] KCRRLPQLCRNYNSFLPP;PDTVHREPQSTPRM;TPPVPDTVHREP 3 13.4 0.98596 -0.43348 0 7.76494 0 0 0 0 0 0 11.7925 0 0 0 0 9.23494 0 A0A8C0PUS5 A0A8C0PUS5_CANLF Zinc finger protein 324A LOC484224 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EAPGRAFPKIPEF;SQEEWELLDA 2 4.1 1.0011 -0.93649 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.09879 A0A8C0PUU5 A0A8C0PUU5_CANLF "Large ribosomal subunit protein uL22m (39S ribosomal protein L22, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] YLKRTQYHGR 1 4.9 0.99985 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7305 A0A8C0PUU8 A0A8C0PUU8_CANLF Tyrosine-protein kinase (EC 2.7.10.2) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] IWPVAAPDDGL 1 2.4 0.98116 0.035491 8.60744 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUV2 A0A8C0PUV2_CANLF Protein spinster homolog 1 (Spns1) SPNS1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] transmembrane transporter activity [GO:0022857] APGLSDSDCSGLPSGVGSS;VEISRRLRRSNPRAD 2 5.9 0.98418 -0.23813 0 0 0 0 0 0 0 0 8.7387 0 0 0 0 0 0 A0A8C0PUV7 A0A8C0PUV7_CANLF HAUS augmin like complex subunit 5 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] HAUS complex [GO:0070652] EVAGRRQLLLQE;FLQDQQSFRCW;VGTLVAQRGPLLKEQILTRRLQGL 3 7.4 0.97422 0.041303 0 0 0 0 0 0 0 0 0 0 0 4.41156 0 0 0 A0A8C0PUW0 A0A8C0PUW0_CANLF Calcipressin-1 (Regulator of calcineurin 1) RCAN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722] nucleic acid binding [GO:0003676] GPGEKYELH;SESETRAAKFESLFRTYDKDITF;VHVCESDQENEEDDEAE 3 24.7 0.9786 0.046279 0 0 0 8.4799 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PUX6 A0A8C0PUX6_CANLF WD repeat domain 93 WDR93 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] AELSRIQPVT;GVLTLWDLAE;GVLTLWDLAEGFPLGV;IACEDGVLTLWD;LSTLEPVT 5 5.7 1.0029 -2.1927 0 0 0 0 0 0 7.22641 9.69667 0 0 9.03593 0 0 0 0 A0A8C0PUX7 A0A8C0PUX7_CANLF Grh/CP2 DB domain-containing protein UBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] VGWEGCSAYGL 1 2 0.98159 0.035491 4.71875 0 0 0 0 0 0 4.65157 0 0 0 0 0 8.20144 0 A0A8C0PUY8 A0A8C0PUY8_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] membrane [GO:0016020] pyridoxal phosphate binding [GO:0030170] EPGGRRPRGLLLLLPLLLLLLLLLP;GGRRPRGLLLLLPLLLLLLL;GRRPRGLLLLLPLLLL;GRRPRGLLLLLPLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLP;LLLLLLLP;LLLLLLPL;LLLLLLPLLLTLLL;LLLLLPLL;LLLLLPLLLLLLLLLP;LLLLLPLLLTLLLPLLLLLT;LLLLTLPLPLPLLLLLP;LLLPLLLLL;LLLPLLLLLL;LLPLLLTLLLPLLLLLT;LPLLLLLLLLLPLLLTLLLPLL;LPLPLPLLLLLPLLLPLTLPLPL;LTLPLPLPLLLLLPLLLPLT;PGGRRPRGLLLLLPLLLLLLL;PLLLLLLLLL;PLLLTLLLPLLLL;PRGLLLLLPLLLLLLLL;PRGLLLLLPLLLLLLLLLP;RPRGLLLLLPLLLLLLL;RPRGLLLLLPLLLLLLLL;RRPRGLLLLLPLLLL;SLHNRLRFL;TLLLPLLLLLTLPLPLPLLL 30 13.1 0.33566 0.60757 5.22959 6.2002 10.07 6.64081 5.80838 0 7.77142 5.14356 8.68664 8.1921 6.4884 8.9174 8.87264 8.35019 8.30866 A0A8C0PUZ6 A0A8C0PUZ6_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] membrane [GO:0016020]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] FLSLFLFFFFFLFSFS;SETVLSPTELQNLD 2 8 0.9819 -0.24965 0 0 0 0 0 0 0 0 10.2825 0 0 0 0 0 0 A0A8C0PV07 A0A8C0PV07_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ENNAEKAFDKIQHPF 1 2.2 0.95012 0.053907 0 0 0 0 0 0 0 0 7.26426 0 0 0 0 0 0 A0A8C0PV14 A0A8C0PV14_CANLF MAP kinase-activating death domain protein MADD Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DTMWRIFTGSLLVEEKSSAL;GGEGSAHL;LKCTVLSLEQSY;NAGDGPGG;SERLLGKKLGIP;TDDSGSDSMDYDDS;TSLCVLSHYPF;VEISRKVYK;VLSKLNRTVQSE;WEDAFLDAVMLER 10 7.9 0.99765 -3.3714 0 8.98003 9.8519 11.2096 5.25576 11.4525 0 0 6.44935 0 9.47739 9.86341 0 9.95833 9.84926 A0A8C0PV21 A0A8C0PV21_CANLF Mitochondrial elongation factor 2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005] mitochondrial outer membrane [GO:0005741] GVNLFGSLRDEEIDA 1 3.3 0.95572 0.053879 0 0 6.43057 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PV22 A0A8C0PV22_CANLF DMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] GPAGARGSCRRA 1 1.6 0.94518 0.05044 0 0 0 0 9.06706 0 0 0 0 0 0 0 0 0 0 A0A8C0PV25 A0A8C0PV25_CANLF O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) SEPSECS Canis lupus familiaris (Dog) (Canis familiaris) conversion of seryl-tRNAsec to selenocys-tRNAsec [GO:0001717]; translation [GO:0006412] cytoplasm [GO:0005737] O-phosphoseryl-tRNA(Sec) selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049] ELFLHELA;LHELAIMD 2 2.2 1.0035 -2.2088 0 0 0 8.83387 8.79422 0 0 0 0 0 0 0 0 0 0 A0A8C0PV26 A0A8C0PV26_CANLF L-lactate dehydrogenase B chain Canis lupus familiaris (Dog) (Canis familiaris) lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] mitochondrial inner membrane [GO:0005743] L-lactate dehydrogenase activity [GO:0004459] KKKKKKKN;TVKKKKKKKNVYLG 2 11.6 0.93974 0.060769 0 0 5.49512 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PV34 A0A8C0PV34_CANLF Ig-like domain-containing protein A1BG Canis lupus familiaris (Dog) (Canis familiaris) ALVFETRPN;ALVFETRPNL;ELLLSDET;ELRIDGPPPRPQLQAL;ELSDPVELQVAGS;FKDGVTQE;GPKAGAKP;GPPPRPQLQAL;LLLSDETLPAPEL;LLSDETLPAPEL;LPIPFVSELSDPVELQVAGS;LRIDGPPPRPQLQAL;LSDETLPAPEL;LSDPVELQVAGS;LVLTYVGPQHAG;PVELQVAGS;SDETLPAPEL;SDPVELQVAGS;TAPPFAGSAPSSSL;TCQARLGTPDFEL;TPGTLVQLRCQAPR;TYVGPQHAG;VSELSDPVELQVAGS 23 23.4 0 35.429 15.6376 15.8658 15.7 13.0194 13.0861 13.1739 15.6843 15.6058 15.6825 14.6976 14.8588 14.5847 15.811 15.8683 15.8824 A0A8C0PV58 A0A8C0PV58_CANLF Cartilage associated protein CRTAP Canis lupus familiaris (Dog) (Canis familiaris) EAFCHRNCSAEPQPE;IAAAHTFLLKH 2 7.2 0.98827 -0.47663 0 0 0 0 0 0 0 14.2935 0 10.3435 0 0 0 0 0 A0A8C0PV76 A0A8C0PV76_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GPGSRRARSAPAPPARE;LENLGSYLVHAENNYLNPCEKRIG;VGRGAGRAGAP 3 4.2 0.98687 -0.39708 10.0868 0 0 0 0 5.07579 0 0 0 0 0 0 10.6448 0 10.3819 A0A8C0PV90 A0A8C0PV90_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] scavenger receptor activity [GO:0005044] CDQTDGSCRC;GECVCNTGYWGPSCNTS;PDACQEDEVC;TDGSCRCEPGWWG 4 5.2 1.0032 -1.1169 0 0 0 5.52457 0 5.83426 0 2.7901 0 0 5.89448 0 0 0 0 A0A8C0PVA6 A0A8C0PVA6_CANLF Klotho Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] beta-glucosidase activity [GO:0008422] DAGGGAASQ;GAGTKAGA;GVQPVVTLYHWDLPQRLQD;IGYTAWSLMDGFE;LGRFCPEEFTL;PENQPLEGTF;PPLLLLLL;PPLLLLLLALGGRRLHAE;PSLRQLLSWIDLE;RDHSLLPYFTD 10 9.6 0.99956 -2.8839 0 0 0 0 5.07206 11.2727 0 0 6.24852 0 8.815 9.02362 8.84734 9.89184 8.7787 A0A8C0PVA7 A0A8C0PVA7_CANLF PWI domain-containing protein SRRM1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] DKKHKKHKKHKKEKAM;TRPRRRHRSRSRRRPSPRRRPSPRR 2 4.5 0.97511 0.035538 7.09159 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PVC2 A0A8C0PVC2_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fibrinolysis [GO:0051918] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GDKPFGPDL;GGQTQEKLPPLTL;GQTQEKLPPLTL;LKLGNQESSG;LSPLSVALALSHLAL;MEPLDQQLMGGQTQEKLPPLTL;MGGQTQEKLPPLTL;QTQEKLPPLTL 8 11.4 0 3.3812 9.51808 0 9.83668 7.2817 8.89963 0 11.0715 11.7123 11.2206 8.77617 8.29297 8.44878 9.74749 10.491 9.89341 A0A8C0PVC3 A0A8C0PVC3_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ALLECLLTPDNVPSDSPKE;AYICSLEVFQITLTE;EMLQVQESTH;ENCWKFFLARVQL;EVEDSLEKVQVA;EVHHLRTATPA;GNAGTGKS;HDAIRNRKKRFVF;IKITNEPP;IKNVLDATCRPN;KKKSLIQKLIILRAVR;KNPYTVLDKANQELELLEEEMLQV;KNVSDDILEKLPEE;LDTWKIYVEFID;LFGELTSSSF;LVYFIDDM;MAHVHTSVNEMSTRYYQNERR;NYGQKMPEQVYIQLE;PLFHTICLIWSH;QAEFRERFRLYAP;SELAHRVEHT;STHRAIGMYSKEKEYS;TVLDKANQE;TYVTRSIDN;VELDEEEDEEEEEE;YQVYCDVEPKRQAL 26 7.2 1.0005 -2.8061 17.9454 9.67083 10.8384 9.99449 6.34643 0 9.31945 10.115 13.2838 0 10.8233 9.26402 4.67785 12.8834 0 A0A8C0PVD3 A0A8C0PVD3_CANLF Cytochrome c oxidase subunit 8 (Cytochrome c oxidase polypeptide VIII) Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] GVVPSPNEAPLSIPSRRGSSSA 1 31 0.9761 0.047946 0 0 0 0 0 0 11.3044 0 0 0 0 0 0 0 0 A0A8C0PVD4 A0A8C0PVD4_CANLF E2F/DP family winged-helix DNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EQTVIAVKAPPQ;FLGLFASSCLVLIIV;KELMSMEQAL;KKKKKRRRRKK;KKKRRRRKKGG;RPRRRRRGRSPSGDLQAP 6 8.6 1.0024 -0.72494 0 8.487 6.85012 5.3929 0 0 9.68589 8.70162 0 4.1842 0 0 0 0 0 A0A8C0PVD7 A0A8C0PVD7_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase 7 Canis lupus familiaris (Dog) (Canis familiaris) GSGRPPGSGAGAP;LHYARNPRITP;LVSFDGFRWNYDQDVH;VEFHKFPNFTFKDI;VEWKANIDTVMKWFT;WNYDQDVHTPNLDAM 6 11.8 1.002 -0.68911 0 0 0 0 10.3607 6.07316 0 0 0 10.3124 0 0 0 0 9.46279 A0A8C0PVE6 A0A8C0PVE6_CANLF Tyrosyl-DNA phosphodiesterase 1 TDP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] nuclease activity [GO:0004518]; phosphoric diester hydrolase activity [GO:0008081] ENISLCQAKLDIAFGTHHT;RKKPILLV;SETNVYLIGSTP;STRYTWEHVGSL 4 8.4 1.0027 -1.4029 0 6.82528 0 0 0 0 9.70075 0 6.69683 0 0 10.056 0 0 0 A0A8C0PVF0 A0A8C0PVF0_CANLF Centromere protein K Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" EDLERVFDELNTKMHDIKEYKE;KEYKEKLLITLGEFLEDH;TKMHDIKEYKEK 3 17 0.99475 -0.15892 8.31764 0 0 0 0 0 0 10.1261 0 0 0 0 0 8.65041 0 A0A8C0PVF2 A0A8C0PVF2_CANLF Peptidase M12B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AESSACGRQHLEP;QGDALCRHMCRA;THQRGMNWGLLS;VGADLFYIQ 4 3.2 1.0034 -1.5665 0 0 0 0 0 7.1921 0 10.7796 10.8148 0 0 0 0 10.2163 0 A0A8C0PVG1 A0A8C0PVG1_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SCF ubiquitin ligase complex [GO:0019005] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LDSPVQAVSPS;LPEEVLEY;SLNSRPSP;SPPLGSSPGSPGSQNL 4 6.4 1.0031 -1.3365 0 0 0 0 8.18869 0 11.8554 11.2975 0 11.2472 0 0 11.0671 0 0 A0A8C0PVG2 A0A8C0PVG2_CANLF C1q domain-containing protein CBLN2 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of synapse structure [GO:0099558] synapse [GO:0045202] LPAGCPVRAQNDT 1 5.8 0.94226 0.059875 0 0 0 0 5.90639 0 0 0 0 5.51286 0 0 0 5.78264 0 A0A8C0PVG3 A0A8C0PVG3_CANLF TBC1 domain containing kinase TBCK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GHVAKHTAE;KDNSHVIQEYLTVFSQMIAFHDP;LQGLQYMNKHGIVHRALSPHNI 3 6.4 0.98642 -0.23161 0 6.33321 0 0 0 0 0 0 0 0 0 0 0 0 8.90063 A0A8C0PVH2 A0A8C0PVH2_CANLF Polyhomeotic homolog 3 PHC3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ASLSSGRPSTSPT;GHALAEGG;QDIADEFRAQE;SPTLTASQAQMYLR;STLVSPGQQIVSPTSHQQY 5 5.8 1.0035 -1.6716 10.158 8.01279 10.5202 0 0 0 0 0 0 0 0 10.9564 0 0 0 A0A8C0PVH7 A0A8C0PVH7_CANLF RNA binding protein fox-1 homolog RBFOX3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] QQPKRLHVSNI 1 3.4 0.9882 -0.26451 0 0 11.4019 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PVI2 A0A8C0PVI2_CANLF Phosphodiesterase (EC 3.1.4.-) PDE7B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" GGGGGGGE;LVMVQEDYHSQNPYH;RGLLENEDAL;SSSGGGGG 4 6.6 0.99357 -0.55757 0 0 0 8.41722 0 0 8.33329 0 0 0 0 0 0 0 0 A0A8C0PVJ0 A0A8C0PVJ0_CANLF EGF-like domain-containing protein LRP8 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] CDEDDDCSDNSDE;CDEDDDCSDNSDEDD;CDEDDDCSDNSDEDDC;CDGEEECPDGSDESEAT;CDGEEECPDGSDESEATCT;CDGEEECPDGSDESEATCTKQVCP;DDDCSDNSDED;DDDCSDNSDEDDC;DEDDCPKKTCADSDF;DEDDDCSD;DEDDDCSDNSDEDDCPKKTCAD;EDDDCSDNSDED;EDDDCSDNSDEDD;EDDDCSDNSDEDDC;EDDDCSDNSDEDDCP;EDPDACSQICVNYKGYFKCECHPGY;GADEASCATSLGTCRGDE;IPSVWRCDEDDDCSDN;LLLLLLLP;LLLLLLLPLRLQ;LLLLLLPL;PVLLLLLLLPLR;PVLLLLLLLPLRLQHL;RCDEDDDCSDNSDEDDC;RCIPSVWRCDEDDDCSDNSDEDDC;RPLAPPVLLLLLLLPLRLQ;VLLLLLLLPLRL;VWRCDEDDDCSDNSDEDDCP;WRCDEDDDCSDNSDEDDCPKKTCAD 29 14.6 0.96606 0.048313 0 0 0 0 0 0 0 0 0 0 0 5.11295 0 0 0 A0A8C0PVK4 A0A8C0PVK4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SIK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CHPHIIRLYQVMETERMI;LVTEYASGGEI;VADPRTEVL;VGAPPSMPRAMAFQAPVNVQPDGTV;VKRATHLVTK 5 5.5 1.0022 -1.7539 0 11.2033 0 7.6074 0 0 10.803 0 0 0 0 0 0 0 0 A0A8C0PVL2 A0A8C0PVL2_CANLF Mimecan (Osteoglycin) Canis lupus familiaris (Dog) (Canis familiaris) growth factor activity [GO:0008083] LPEEKSLQLQKDERVM;PESLRVIHLQ;RMTYDYGTDNF 3 12.5 1.0041 -0.82645 0 0 0 0 0 0 0 8.08135 0 0 0 0 0 0 10.2206 A0A8C0PVM2 A0A8C0PVM2_CANLF WD repeat domain 27 Canis lupus familiaris (Dog) (Canis familiaris) CGCYVASGAEDRHAYMYDLG;RPCTHGLEKGEEVEASLPVLGLAPC;RVSLKKKSESFSRRVESRLCSL;SPLLQERSWHPVL;TAVAFGNT;VLHYRDFRSL 6 8 1.0022 -1.2987 7.20955 0 11.4019 9.59679 0 7.09117 0 8.22004 13.4883 0 0 0 8.53267 1.74528 0 A0A8C0PVM4 A0A8C0PVM4_CANLF "NRDE-2, necessary for RNA interference, domain containing" Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] ALNGGETFRTDKKPDPA;DDEDDEPEDE;EMQEILDLMTEK;FAIEAEKMRKTLVESVQ;KKKKRKHHHKKIKRKH;KQTSRKKKKEKKKKRKHH;NKKPKQTSRKKKKEKKKKR;QEKRKRSLKLVLEK;SSSGSEPD;STSSGGSSEDAGSAQSPS 10 10.8 1.0032 -0.79663 10.1085 0 0 9.8676 7.38517 4.84499 5.97682 0 4.77225 0 3.51879 5.86419 7.17353 0 0 A0A8C0PVQ9 A0A8C0PVQ9_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) GGCGWHCTRRCGCLSNGEE;KQLVVQEALLTILREL 2 18.1 0.95265 0.049538 0 0 5.20797 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PVR6 A0A8C0PVR6_CANLF Aryl hydrocarbon receptor interacting protein like 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] KMQAVPIL 1 3 0.99063 -0.26592 0 0 0 0 0 0 12.9753 0 0 0 0 0 0 0 0 A0A8C0PVR8 A0A8C0PVR8_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2B2 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] AADQEPVGHSAVV;SLLVDNVKERATWFRTPH;VLDQYNYCSCLP;VYTTVVEQLMLQKQRRFI 4 6.2 0.9925 -0.55336 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5325 A0A8C0PVS8 A0A8C0PVS8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;VLSQKQTHRSMEQNRESRSGPST 4 8 0.97708 0.046444 0 0 0 0 0 0 0 0 7.98362 0 0 0 0 0 0 A0A8C0PVT2 A0A8C0PVT2_CANLF inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) INPP5A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] inositol-polyphosphate 5-phosphatase activity [GO:0004445] KGFVRTRWCVAD;VGSLFDDVVH 2 5.6 0.98763 -0.48538 0 0 0 0 0 8.94298 0 0 0 0 8.20823 0 0 0 0 A0A8C0PVU7 A0A8C0PVU7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RRRNSKRDYTGGT;SGSHQGPVIYAQ 2 8.9 0.98912 -0.52221 0 0 0 0 0 0 0 0 0 0 0 10.0852 0 0 0 A0A8C0PVV5 A0A8C0PVV5_CANLF Establishment of sister chromatid cohesion N-acetyltransferase 1 ESCO1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] acyltransferase activity [GO:0016746]; metal ion binding [GO:0046872] AGQKRFGAVSCNVCG;DGKLFATQYCGTEEE;EQSVDNELEQAGRSKRG;PKCNSHLEITIP;SEKYLQKNVKK;TDNERQILHQKE;TLPEPAICGISRIWVFSMM;VEHQTAYTC 8 13.1 1.0022 -1.1341 9.4302 0 7.33682 0 9.49217 0 0 0 0 0 0 7.47419 7.62132 7.61603 6.1435 A0A8C0PVX8 A0A8C0PVX8_CANLF Ig-like domain-containing protein MPZL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IEVSDDTDQEEGDDCMA;TIKDNGTFSCAVKNPP 2 15.3 0.98893 -0.22647 0 0 0 6.71658 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PVY9 A0A8C0PVY9_CANLF CG-1 domain-containing protein CAMTA2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255]; regulation of primary metabolic process [GO:0080090] DNA binding [GO:0003677] LITGPWTEAAE;MKLKVQGMECLYGCYVHS;VEQLVQQIL 3 3.2 0.99129 -0.22167 0 9.4031 0 0 0 0 0 0 0 0 0 0 0 9.41671 0 A0A8C0PW05 A0A8C0PW05_CANLF Cytosolic carboxypeptidase 1 (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Protein deglutamylase CCP1) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AGEEASGN;EDIKDNDRTSQQQLGDQNR;IERLIHQSDIIDRVVYDLDNPN;KSKESTARVVVWREIG;LNLVKQNL;RTIEELKMYE;SDIIDRVVYDLDNPN;SHIAPAFCMSSCSFVVE;SLSGEDLNRQWQSPNPDLHPTIYHA 9 10.7 1.0036 -1.5969 0 6.58705 9.80004 0 0 0 9.85986 0 8.59515 9.5097 6.35491 9.51859 0 0 0 A0A8C0PW08 A0A8C0PW08_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ICDIFYNLHPMVCGVLW;KTPTQARRRNLYKKLRVKPGLAFLR;PKDMGCHLKATRSWESGCVTL;PRRNRRQKKKK 4 21.9 0.85613 0.16758 0 9.79041 0 3.34511 0 0 5.87327 0 6.89881 0 7.32652 0 0 0 0 A0A8C0PW12 A0A8C0PW12_CANLF Par-6 family cell polarity regulator gamma Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] SARCAQTRATAWPC 1 3.3 0.98914 -0.21849 0 0 0 0 0 0 0 0 0 0 0 0 10.5293 0 0 A0A8C0PW13 A0A8C0PW13_CANLF Zinc finger protein 181 LOC484590 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATGESVYKYDTF;EFSDFNNDWEY 2 4.3 0.99286 -0.27174 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.02565 A0A8C0PW24 A0A8C0PW24_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EISRCRQRGQDKEREERLEQGE;QLVLECLWQALLVITGSWGH;VGLVFLVKRRLTPRRGKALG 3 11.7 0.97331 0.048206 0 0 0 0 3.90429 0 0 0 0 0 0 0 0 0 0 A0A8C0PW45 A0A8C0PW45_CANLF Fibrous sheath-interacting protein 1 FSIP1 Canis lupus familiaris (Dog) (Canis familiaris) ALTGHFTSRALVIE;DSSTSLEVLSPE;ETKFTEVKDVDVLEN;EYENHIQN;RPGSRDSSTSLEVLS 5 9.5 1.0025 -0.79952 0 0 9.44346 6.18166 0 0 0 0 0 0 8.58459 0 0 0 0 A0A8C0PW53 A0A8C0PW53_CANLF C2 domain-containing protein MCTP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DMLEDEEEEDDKDDK;DVPLADPG;EEKACILVEHLRE;IPLRYIVLVWGI;PWPQKINTAGTSNADVPLADPG 5 8.8 0.98931 -0.26515 0 0 0 9.94018 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PW60 A0A8C0PW60_CANLF Voltage-dependent calcium channel gamma-6 subunit Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262] AAGGCGPA;AEGSRAAS;VLAVGTEFWVELNTYK 3 10 1.0033 -2.1464 0 9.48111 0 0 0 9.97226 9.90263 0 0 0 0 0 0 0 0 A0A8C0PW80 A0A8C0PW80_CANLF 14-3-3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] IRVVILFPLEKPFYSSP 1 9.7 0.98466 0.046227 0 0 0 0 0 0 0 0 0 7.8182 0 0 0 0 0 A0A8C0PW92 A0A8C0PW92_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AERANGERPR;AQPPTSHSQEEQWLEQRLER;ETDVAERR;EVPPELWPEGP;LAHVIARH 5 5 1.0015 -2.6484 0 0 9.2659 0 0 6.17387 0 0 0 0 10.0429 0 8.83441 0 0 A0A8C0PWA7 A0A8C0PWA7_CANLF F-box only protein 25 FBXO25 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] DHFRNDTNTQCFY;PREQYGDTLHFCRHCS;RHCSILFWKSTCR 3 11.4 0.98832 -0.47319 0 8.78418 0 0 8.76015 0 6.64121 0 0 0 0 0 0 0 0 A0A8C0PWA8 A0A8C0PWA8_CANLF Nucleoporin NDC1 (Transmembrane protein 48) Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] EQFHRPLDTVRGLLNLSLLYH;LLMTWYSWILFKIFATEAHLFP;PGGHPHNWTAIS;SIDLFHPIQWLSDSFNDLYSSYVI 4 11.7 0.9879 -0.48887 0 9.44375 0 0 2.38835 0 0 10.8068 0 0 0 0 0 0 0 A0A8C0PWB9 A0A8C0PWB9_CANLF SID1 transmembrane family member 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEAKKEHTHLLESNQQ;EAEERKQRTELLGHLTRE;EANRKWLE;GYQDRSLDPVGT;IINWSLAAYGLIM;KLRRRATGFWR;LDSMSSVE;MLEQLKEEME;SLPFYPFV;YHVCPNYTNFQFDTS 10 7.6 1.0019 -1.8219 0 0 0 0 9.46064 8.5713 0 0 0 0 0 0 0 0 9.5518 A0A8C0PWD4 A0A8C0PWD4_CANLF Cytosolic Fe-S cluster assembly factor NUBP2 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]" AGKKVSPP 1 8.2 1.004 -1.1044 0 0 0 0 0 0 0 0 0 7.14914 0 0 0 0 0 A0A8C0PWD9 A0A8C0PWD9_CANLF PDZ domain-containing protein LRRC7 Canis lupus familiaris (Dog) (Canis familiaris) DEDFQSDSDSFNP;DNGQEDVSPSGQW;EQRQQRMTVAFE;ESEVDKTHCLNNSVSSGTYS;ETKQRVLTNYMFPQQ;IPSSQATRGPQPGRCLIQT;LDMSKNRIETVD;LPEVLDQIQNLREWMDNNALQ;PETKQRVLTNYMFPQQ;PGSIGKLKM;RGITLQPARLSGDCCTPWARCDQQ;TLEELYLDANQIE 12 11.5 1.0027 -1.194 0 0 9.7598 6.70529 0 11.1299 0 0 0 0 0 5.48149 10.1657 0 14.961 A0A8C0PWE4 A0A8C0PWE4_CANLF Senataxin Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] ADPLAGGDPTIHHLELATLKE;AKVSKERQELASKIKE;DIVSYHENSYQ;IINNVSYNREIQNI;INNVSYNREIQNIRNS;ISDSDDDDDE;IVSPSADP;KIEVKKRKRKRF;SERNEDQPDI;VETPENQGEYCSKHCEAKAADEDVF;VGDGSERRDND;VGDPKQLPPTVISM;VISSLVTTQRKLK;YNKEESEQIERKSKKDLFCLENS 14 7 0.99935 -0.61146 0 0 5.266 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PWH7 A0A8C0PWH7_CANLF PBX homeobox interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) DDGCTREPS;EDLEGQSPPQSQP 2 3.2 1.0036 -0.80471 0 0 0 0 0 0 0 0 0 6.6437 0 0 0 0 0 A0A8C0PWH8 A0A8C0PWH8_CANLF Acyl-coenzyme A oxidase ACOX3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504] DAVALVDVIAPPD;DAVALVDVIAPPDFVLDSPIGR;EIFGCFAVTELSH;ELGREIHALV;PGVMIGDMGKKVGLNGIDNGFA;VGNMGKTATHAVVFAQLYT 6 13.4 0.99115 0.0026702 0 0 0 0 0 0 0 6.49752 6.72601 0 0 0 11.0319 7.7012 10.1553 A0A8C0PWI4 A0A8C0PWI4_CANLF Slit guidance ligand 3 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] CLSSPCKNNGTCSQDPVELY;DCEDNDCE;DNDCENNA;EINPDDCEDNDCENNATCV;GAPKSLGKLQKQ;GPHSEPPSCNAN;HLEDNQVSVIERGAFQDLKQL;KRIGQIKSKKFRCSGSED;QTSPCDQYECQ;RNAERLDLD;TFSNMSHLSTLILSYN;VEEVERHLE;YKEPGIARCSSP 13 10.4 1.0017 -1.2566 0 0 8.21718 6.55099 7.20291 5.74486 0 6.66434 0 7.71184 11.152 8.38625 6.53458 7.68601 7.1817 A0A8C0PWL4 A0A8C0PWL4_CANLF Solute carrier family 29 member 3 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] nucleoside transmembrane transporter activity [GO:0005337] APGSSESSTPPLWPILK;GRNPQVQTSWVPIHV;IVPRELAEATGVVMSFYV 3 11.2 0.93685 0.064813 0 0 0 0 0 0 7.28679 0 0 0 0 0 0 0 0 A0A8C0PWL5 A0A8C0PWL5_CANLF Slit guidance ligand 2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] extracellular region [GO:0005576] calcium ion binding [GO:0005509] ADGFEGENCEVNVDDCEDNDCENN;DCEDNDCE;DCEDNDCENNSTC;DDCEDNDCENNSTC;DEDSGILLYKGDKDHIA;ENCEVNVDDCEDNDC;EVNVDDCEDNDCE;FEGENCEVNVDDCEDND;GACQPSSQSGFTCE;GANPLYCDCNMQ;NDCENNSTCVDGI;NEILLTSNRLE;PQACPAQCSCSGSTVDC;QDVAIQDFTCDDGNDDSSC;VDDCEDNDC;VDDCEDNDCENN;YCECSSGY 17 8.5 1.0001 -2.8313 6.62761 9.33333 9.10949 0 9.9608 0 7.51001 6.66974 9.96311 7.83725 6.58904 8.14292 8.34842 5.1643 0 A0A8C0PWL9 A0A8C0PWL9_CANLF Raptor N-terminal CASPase-like domain-containing protein RPTOR Canis lupus familiaris (Dog) (Canis familiaris) TOR signaling [GO:0031929] TORC1 complex [GO:0031931] AWQGLSDMLPTTRGA;FETIDKMRRV;GLGEEDEADLTD;GVQYTPHSQQF;QREQELEVAAINPN;RRVSSYSA;VGSNDYYIS;YMPAEHRTMTAF 8 6.8 1.003 -2.3113 0 9.47798 10.4504 0 0 0 9.82876 0 0 7.97275 0 10.121 0 0 0 A0A8C0PWM0 A0A8C0PWM0_CANLF Glucosylceramidase beta 3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" KSQIAFMS;SYTLWEEDLK 2 3.8 1.0021 -1.3649 0 0 0 0 0 0 0 0 8.6749 0 0 0 0 0 10.1246 A0A8C0PWN3 A0A8C0PWN3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] LILSPRPQDHGT 1 2.9 0.98384 -0.24233 0 0 0 0 0 0 0 0 0 0 0 0 11.1908 0 0 A0A8C0PWN4 A0A8C0PWN4_CANLF Centriolar coiled-coil protein 110 CCP110 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; ciliary basal body organization [GO:0032053]; negative regulation of centriole elongation [GO:1903723]; regulation of cytokinesis [GO:0032465] centriole [GO:0005814] CSSKVCVTKNTSEAIQ;LEKKVIHGLAIVEGQ;LSPLVRKAP;PSLSEEVTPDPYI;QERLQKEIEE 5 6.5 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 5.23078 0 0 A0A8C0PWP3 A0A8C0PWP3_CANLF F-actin-capping protein subunit beta Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; negative regulation of filopodium assembly [GO:0051490]; regulation of lamellipodium assembly [GO:0010591] cytoplasm [GO:0005737]; F-actin capping protein complex [GO:0008290] actin filament binding [GO:0051015] DSIHVVEVQ;LLKPEAWEAPGG;PRAPPRGAAPAARVLLG 3 10.8 0.98551 -0.43885 0 0 0 0 0 0 0 0 0 11.9496 9.61053 0 0 0 11.8503 A0A8C0PWQ9 A0A8C0PWQ9_CANLF tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) TRMT44 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; tRNA (uridine) methyltransferase activity [GO:0016300] AELRPPRTPKKK;DKTLFPDVDWL;DWLIGNHSDELTPWIPVI;GSLSLTEVASELDPETLQ;REYLDFITEVGLACGFHVEE 5 10.2 0.50595 0.47649 0 0 0 0 7.25541 8.76563 10.1022 0 0 0 4.83845 6.34113 0 0 0 A0A8C0PWS4 A0A8C0PWS4_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480] basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; presynaptic membrane [GO:0042734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] AYSVKKMMK;DPVRPEVP;MKRKRKRKVRLKQDGA;NWLRCWYL;SELSIEQWLW 5 5.3 1.0039 -1.0725 0 5.94038 0 0 0 0 0 7.88826 0 0 0 0 0 0 0 A0A8C0PWU6 A0A8C0PWU6_CANLF RAS guanyl-releasing protein 1 RASGRP1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; small GTPase-mediated signal transduction [GO:0007264] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085] ELEQKLNSCDTLGLVSG;PSPVLVRKRAFVKWE;QRMVDSVFKN;SLLFDHLEP 4 6.5 1.0018 -0.6737 0 10.981 0 0 0 0 0 4.08406 0 10.8629 0 0 0 0 0 A0A8C0PWV3 A0A8C0PWV3_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] DPLDHPWYLPLSDGPL 1 3.3 0.96316 0.049233 0 0 0 0 0 0 7.73491 0 0 0 0 0 0 0 0 A0A8C0PWV7 A0A8C0PWV7_CANLF Zinc finger protein 541 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] CCTASPSQ;ELALHCLHEAQGDV;GSAAKGQEKDGE;LDLGDIFSPG;LGLGVLKMPKEAD;PSREGCESAPG;QTKTVAQCVEYYY;SPGGPRQTQLGGEETLGAPLP;VPEEPRPPRKE 9 8.3 0.98435 -0.25467 0 0 0 0 0 0 0 0 0 12.7089 0 0 0 0 0 A0A8C0PWW3 A0A8C0PWW3_CANLF SH3 domain-binding protein 5 (SH3BP-5) SH3BP5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124] EDDSETQS;ENRMKQLSLQCSKG;RIQGELEKLNQSTDDI 3 8.4 0.98792 -0.37611 9.888 0 0 0 0 0 0 0 0 8.65521 9.79633 0 0 0 0 A0A8C0PWZ4 A0A8C0PWZ4_CANLF Protein-tyrosine-phosphatase Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] PRVTHIMIHFQYDI 1 2.5 0.93804 0.060957 0 0 0 0 5.47839 0 0 0 0 0 0 0 0 0 0 A0A8C0PX00 A0A8C0PX00_CANLF "MN1 proto-oncogene, transcriptional regulator" MN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AFHAGGPP;AGEARGAPTPHEKALTSPS;GAGGGGGG;GDVGQGGL;GGGGGGGA;GGGGGGGG;HFDMFSPSDSEGQL;LDQSPNRAA;PGGHHPHQHHPHFGG;SGGLQDGGPMLPSQ;VGGLAQPN 11 8.7 1.0023 -1.864 0 10.8803 0 0 0 6.82413 0 10.2422 12.0012 9.85406 0 0 0 0 0 A0A8C0PX11 A0A8C0PX11_CANLF Adhesion G protein-coupled receptor A3 ADGRA3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] FLTCVVFVGG;FQCMASYIDQ;ISSIDPGAFWGLSSL;LDGLGTLPGSLLRARRLHHLRQLH;LEFQTEYLLCDCNILWMH;LPDWRRHP;LQLLLRGRVPELRRLRRGP;SLSNYAVLMDLTGS;TFDYLGSLRSLEFQT;VFQKVAAS 10 10.5 1.002 -0.75413 9.43406 10.5413 8.97482 0 0 8.56464 0 0 0 12.4855 0 9.79479 0 11.241 0 A0A8C0PX20 A0A8C0PX20_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] membrane [GO:0016020]; synapse [GO:0045202] transmembrane transporter activity [GO:0022857] ESDTGTWYRRCFVRIRTELYGI;GVEVFVVGFV;GVLCLYNGLTISAWNSL;PPGETYDGEANDDEGSSE;VCALPCVSSVVALTFMPESPLSPS;YPPGETYDGEANDDEGS 6 12.8 0.97314 0.041303 8.85845 0 0 0 0 0 0 9.08393 0 0 0 0 0 0 0 A0A8C0PX25 A0A8C0PX25_CANLF U2A'/phosphoprotein 32 family A C-terminal domain-containing protein ICOSLG Canis lupus familiaris (Dog) (Canis familiaris) ETSVVGQPKTVTYYLSGNS;TLSVNSVSSLEPVSQCQQ 2 8.7 0.95072 0.049892 0 9.59098 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PX36 A0A8C0PX36_CANLF Homeobox and leucine zipper encoding HOMEZ Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] CLDEEEEEEEEELPE;DEDEEEEEEEDDDDDDDVI;DEEEEEEEEELPEDDEDEEEE;EDDDDDDD;EEEEEDDDD;EEEEEDDDDDDD;EEEEEEDDDDD;EEEEEEDDDDDDD;EEEELPEDDEDEEEEEEEDDDDD;ELPEDDEDEEEEEEEDDDDDD;LDGNEHLLQTFSYFPYPSLAD;LPEDDEDEEEEEEEDDDDD;PEDDEDEEEEEEEDDDDDDD;PEPAEVVVCLDEEEEEEE;RPEIIQWFG 15 13.4 0.98741 -0.46233 0 0 0 6.25267 0 0 0 8.11889 0 13.6885 4.62439 4.25073 12.985 7.13052 11.692 A0A8C0PX54 A0A8C0PX54_CANLF Elongin-A RPL11 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368]; translation [GO:0006412] elongin complex [GO:0070449]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] DEADMDDEFEQP;DEADMDDEFEQPTMSF;FKIFFFFFFFFFRFYFIHDREAEGE;RCHRISPV;TLSPNKFKIFFFFFFFFFRFYFIHD;TMSFESYLSYDQPRKKKKKM;VGSFARDLVAQW 7 7.9 1.0019 -0.66157 0 0 8.21747 0 8.90379 0 0 8.89464 0 0 0 0 11.4779 9.47435 10.8881 A0A8C0PX77 A0A8C0PX77_CANLF Myeloid zinc finger 1 MZF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AGLTDQLQSP;SEKMEPSNFQPLLQ 2 3.2 1.0032 -0.86851 0 0 0 0 0 0 0 10.8586 0 0 0 0 0 0 0 A0A8C0PX97 A0A8C0PX97_CANLF Tripartite motif-containing protein 16 TRIM16 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526] cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605] DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; zinc ion binding [GO:0008270] EPVKDRDLRTC;GVEPDAVTLIHKFECRFSEPVYPAF 2 6 0.98366 -0.24303 0 0 7.63372 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PXC5 A0A8C0PXC5_CANLF JmjC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TGPWRDVHKDWR;VEGPMAEDTQE 2 5.3 0.99069 -0.21109 0 0 0 0 9.93714 0 0 0 8.39489 0 0 0 0 0 0 A0A8C0PXF1 A0A8C0PXF1_CANLF Tripartite motif containing 67 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] zinc ion binding [GO:0008270] AAAAPPLDQDP;KEREHKLKMVWDQI;MLGKDDKA 3 4.7 0.9264 0.09626 9.31628 0 0 0 0 5.56611 0 0 0 0 0 0 0 0 0 A0A8C0PXF2 A0A8C0PXF2_CANLF PHTF1/2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ESIPFIGGFWGTL;LWDDLLHGP;VLIGPCQFGSEFRDDIIRFV;VNTLHSGTKRDPKED 4 8.3 1.0019 -1.2066 0 9.45173 0 0 9.22151 0 0 12.8916 8.46181 0 0 0 0 15.6811 0 A0A8C0PXG0 A0A8C0PXG0_CANLF "N-acetyllactosaminide alpha-1,3-galactosyltransferase (EC 2.4.1.87) (UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase)" GGTA1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi cisterna membrane [GO:0032580] hexosyltransferase activity [GO:0016758]; metal ion binding [GO:0046872] EGTYNSTILENYYAKQKI;EIEPEKRWQDISMMRMKTIGEHIVA;FCMDVDQVFQDSF;FWEYINSPEGSFLWI;IVVFWEYINSPE;IYQEEEDIDDENE;PRGAAPPAL;QGDFYYHAAIFGGTPIQ;SVAQLQAWWYKAD 9 16.6 0.99103 -0.51373 7.9939 7.87332 9.42095 5.00796 0 0 0 9.58905 0 0 12.0909 0 8.50526 0 0 A0A8C0PXG5 A0A8C0PXG5_CANLF C-terminal binding protein 1 CTBP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; transcription corepressor activity [GO:0003714]" DLLFHSDCVTLHCGLN;GPVPAYGG 2 3.6 0.9892 -0.21669 0 0 11.6786 10.7148 0 0 0 0 0 0 0 0 0 10.0963 0 A0A8C0PXG6 A0A8C0PXG6_CANLF Transmembrane protein 50A TMEM50A Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; protein targeting to vacuole [GO:0006623] membrane [GO:0016020] FIFFGLCP;MWILFGGYVA 2 9.7 1.0028 -1.1221 0 0 0 0 0 0 0 0 0 0 8.12195 0 0 0 0 A0A8C0PXH3 A0A8C0PXH3_CANLF L-lactate dehydrogenase B chain Canis lupus familiaris (Dog) (Canis familiaris) lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] mitochondrial inner membrane [GO:0005743] L-lactate dehydrogenase activity [GO:0004459] NPDSSSVNNGEGHSSVYPECS 1 12.4 0.98439 -0.24181 0 0 0 0 0 0 0 0 0 0 0 0 0 11.6344 0 A0A8C0PXH9 A0A8C0PXH9_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) sulfotransferase activity [GO:0008146] RTFDPLGCM;VTYLCYSL 2 4.5 0.9878 -0.46917 0 0 0 0 10.3682 0 0 0 0 0 9.70729 0 0 0 0 A0A8C0PXI0 A0A8C0PXI0_CANLF Fas-binding factor 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162] ciliary transition fiber [GO:0097539] ALGDLSSAGLFPTF;EKDQEMERLRELQRASILEMRKDHE;EQSRVESTQRAL;ITKKPPGAA;KLELERAQHQL;SSAGLFPTFP;WERAEREAERALQVDTQREGTLV 7 9.6 1.0019 -1.8178 9.14257 0 7.09476 5.74784 6.30848 0 6.89033 0 0 9.51893 10.1929 0 11.055 7.45672 7.64118 A0A8C0PXJ6 A0A8C0PXJ6_CANLF Laminin subunit alpha 2 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] AEECYYDENVARRNLSLNIHGKYI;ARLIERCECPA;CDCSHLGNNCDPKTGQCICPP;CDQCCPGFHQKPW;CQECECDP;CQNCQHHTAGDFC;DCEESGQCWCQPG;DLRLEPFYWKLPEQ;GAALALRLPLPLLLLLLGG;GLDAKNPLGCSQC;GYYWSAPAPYL;PGAALALRLPLPLLLLLLG;PVSRREFMTVLASLKRVLIQ;QEGGCTACD;QPSVPGGSCQPCQ;RRLVLKKKNQ 16 11.3 0.99927 -0.61146 4.01042 0 0 0 0 0 0 0 0 4.64852 0 0 0 0 0 A0A8C0PXJ7 A0A8C0PXJ7_CANLF Non-specific serine/threonine protein kinase AKT1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ESPPAFAL;IVWQDVYEKKLSPPFK;PDQGDNMEGEDS;SLAKPKHRV 4 7.7 1.0021 -1.7969 0 0 0 0 0 7.86703 10.1233 11.3566 0 0 0 0 3.53431 0 9.23946 A0A8C0PXK8 A0A8C0PXK8_CANLF Acetyl-CoA carboxylase 1 (EC 6.4.1.2) ACACA Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295] cytoplasm [GO:0005737] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] AEGIPRIFV;DPRWMLAGRPH;LELQDIMTSVSGRIPPNV;LGREVYTSNNQ;MTLKSPEYPEGRDIIVIGND;NFFYHSNQVVRMAALE;PAAIATPAVF;RAIGIGAYLVRL;RHLEVQILADQ;YISRDYVL 10 5.5 1.003 -0.85034 0 9.9485 10.3786 8.25342 0 9.58808 10.0367 0 0 0 0 0 0 9.51074 3.82833 A0A8C0PXM7 A0A8C0PXM7_CANLF "CRK proto-oncogene, adaptor protein" Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; regulation of cell motility [GO:2000145]; regulation of intracellular signal transduction [GO:1902531]; signal transduction [GO:0007165] receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591] NAYDKTALALEVGE;VSHYIINSSGPRPS 2 7.8 0.98474 -0.2417 0 0 0 8.40348 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PXN0 A0A8C0PXN0_CANLF "Golgi associated, gamma adaptin ear containing, ARF binding protein 3" GGA3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] early endosome membrane [GO:0031901]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] GSSSSVLAPAPPSSGI;NEVGKFRFL 2 3.4 1.0012 -0.94527 0 0 0 0 0 0 10.392 0 0 9.06366 0 0 0 0 0 A0A8C0PXP0 A0A8C0PXP0_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ESYDEEEEDGKG;PVASSGVTGKGKTLSSQ;PVNSAAVLRKGQP;TQQGTDPLVLAVQ 4 7.6 1.0022 -1.0148 8.87018 0 0 0 0 8.65381 0 0 13.1696 0 0 0 0 0 0 A0A8C0PXP1 A0A8C0PXP1_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) reciprocal meiotic recombination [GO:0007131] synaptonemal complex [GO:0000795] metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789] ALHCVGAPRRGCGP;EESLQKSVLRMEQLQSMRL;QEKHRRRLLAF 3 13.8 0.98564 -0.44355 0 0 0 8.92285 0 0 0 0 0 0 0 0 10.019 10.0515 0 A0A8C0PXP7 A0A8C0PXP7_CANLF Conserved oligomeric Golgi complex subunit 7 (Component of oligomeric Golgi complex 7) Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119] AVPLEHGEVIDCV;DKWSTLSADIE;DLPLDRQLTGFYD;EEKNVLIQISAVPLEHGE;QQLLLVSKMDSWNTAG 5 8.9 1.0009 -0.62578 0 0 0 0 0 0 0 10.762 9.26449 0 0 0 0 0 0 A0A8C0PXQ5 A0A8C0PXQ5_CANLF TNFR-Cys domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] tumor necrosis factor receptor activity [GO:0005031] VLGLGLGLLAPV 1 3.9 0.94279 0.05044 0 0 0 0 0 0 0 5.86795 0 0 0 0 0 0 0 A0A8C0PXR6 A0A8C0PXR6_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2A1 Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] APLPFQQGAL;EGRAIYNNMKQ;LVTDGLPAT 3 3 0.98814 -0.26491 0 0 0 0 0 0 0 8.87338 0 0 0 0 0 0 0 A0A8C0PXS3 A0A8C0PXS3_CANLF Deacetylase sirtuin-type domain-containing protein SIRT1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; rDNA heterochromatin [GO:0033553] metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone deacetylase activity [GO:0017136]; p53 binding [GO:0002039]; transcription corepressor activity [GO:0003714]; transferase activity [GO:0016740] DDDDDEGEEEEEAAAA;DDDDEGEEEEEAAAAAA;DDFDDDDDDDEGEEEE;DFDDDDDDDEGEEEEEA;EDSSSPERTSP;PADDFDDDDDDD;QAAAAAAGEGDNGPGLQGLSREPPP;RCPRCPAD 8 9.1 0.98878 -0.30173 5.68972 0 8.71304 0 0 11.2353 0 12.4368 0 0 0 0 0 5.05537 0 A0A8C0PXS4 A0A8C0PXS4_CANLF HGF activator HGFAC Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; zymogen activation [GO:0031638] extracellular space [GO:0005615]; rough endoplasmic reticulum [GO:0005791] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] CRLAACESLA;LPVPGCHA;LVLIRLKKKGDRCAIRSQFVQPIC 3 6.8 0.98433 -0.23839 0 0 0 0 0 0 0 0 0 0 7.57856 0 0 0 0 A0A8C0PXT7 A0A8C0PXT7_CANLF Teneurin transmembrane protein 2 TENM2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell projection [GO:0042995]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AISHTGVL;GVCIGGACRCEEGWTGAAC;ISLPMENGL;LAVDPVSGSLYV;NWMGPDCSVEVCSVDCGTHGV;SSGEEYYV;VDCGTHGV;VHLMVAVEGHLF;YSLSTGSDADSDTE 9 3.6 0.98687 -0.35934 13.3375 11.6605 12.9969 0 0 9.58182 13.3316 0 0 11.1181 4.77763 10.1524 15.3492 13.1931 15.5037 A0A8C0PXV2 A0A8C0PXV2_CANLF Proheparin-binding EGF-like growth factor LOC102152612 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] growth factor activity [GO:0008083] GATVPGARGQGRCSDSTAGHLVGP 1 9.1 0.99406 -0.28554 0 8.89048 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PXV5 A0A8C0PXV5_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] ALVLLGLLVLLLLLLGSIILALRQ;EPDCESPHCD;EPEPDSGGDWSAELP;LLLLLLGSIILALRQR;LSELCFSQVIWEG;LVLLGLLVLLLLLL;LVLLGLLVLLLLLLGSIILAL;LVLLLLLLGSIILALR;NLTQDQAQVE;PEDCLSLDVCY;TCSCGTDFCNANYS;VLLGLLVLLLLLL;VLLGLLVLLLLLLGSIIL;VLLGLLVLLLLLLGSIILALR 14 16.6 1.0031 -1.3829 0 7.28068 5.95056 0 6.24607 5.81975 0 0 0 7.35394 9.87409 0 6.51691 5.46842 4.08907 A0A8C0PXV8 A0A8C0PXV8_CANLF Hes related family bHLH transcription factor with YRPW motif 2 HEY2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] APRRDEAPVRGD;GAGGGGGG;PLAVAAAAGPQP 3 6.7 0.98834 -0.4759 0 0 0 9.68306 0 0 0 0 0 0 8.58811 0 0 0 0 A0A8C0PXZ1 A0A8C0PXZ1_CANLF AHNAK nucleoprotein 2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] costamere [GO:0043034]; nucleus [GO:0005634] APPELISTGCP;FPTLTVPRFSFP;GVKASTGG;LSGPPECSS;RGSPVKAPRLKLPSFSW;VLSPLPTLPETHP 6 7.1 0.99189 -0.14459 0 9.62452 0 8.53438 0 9.53382 6.13506 10.201 11.0703 0 9.57669 9.40693 0 0 0 A0A8C0PXZ3 A0A8C0PXZ3_CANLF Nucleosome assembly protein 1 like 4 NAP1L4 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] AHIEAKFYEEVHDLERKY;DDNFEEGEEGEEEELEGDEEGEDE;VLYFTGEAIEDDD 3 14.1 0.97419 0.041303 0 0 0 0 0 0 0 5.31321 0 0 0 0 0 0 0 A0A8C0PY01 A0A8C0PY01_CANLF Spermatid perinuclear RNA-binding protein STRBP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DNA binding [GO:0003677]; RNA binding [GO:0003723] LKHVSDWLDETNKG 1 2.4 0.93778 0.097368 0 9.18718 0 0 0 0 0 0 0 0 0 0 0 0 10.5779 A0A8C0PY07 A0A8C0PY07_CANLF Ig-like domain-containing protein LSR Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] ASQQDDSMRVLY;CQCCPHTCCCYVRCPCC;CWCQCCPHTCCCY;FQPVTLPCTYQ;LRKKGPAERRR;WCQCCPHTCCC 6 9.3 0.98725 -0.36431 0 0 0 0 0 3.12795 4.36723 6.03725 5.13508 0 0 0 0 0 10.448 A0A8C0PY12 A0A8C0PY12_CANLF Carbohydrate sulfotransferase (EC 2.8.2.-) CHST8 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] AALGAGGGP;GSRQRTPRRGGPSPG;LTFPRFKDRHSQEART;QIARRYFTQLSALQRQRTYD;VLAGLASS 5 10.5 1.0023 -1.8461 0 0 0 9.60716 0 0 9.37171 16.085 0 0 0 0 0 6.77926 0 A0A8C0PY17 A0A8C0PY17_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP32 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843] IAVHRKMMR;LYSATPGADMCFARQHNTSDNN;PLIVPCTVHTRK;QDNQKVRLS;SSMDEDFESDYKKYCVL;VLGDGVPP 6 5.1 1.0028 -0.84867 0 0 0 0 8.14011 2.87247 10.5732 7.22968 4.334 0 0 9.84687 7.86282 0 0 A0A8C0PY20 A0A8C0PY20_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DVSPSVNQIKV;GGSRRRLRAA;GVLFVFSGPGKDP;TECSCEMEEDVSP 4 9.3 1.004 -0.82833 0 0 0 0 0 0 0 0 0 0 0 5.65114 0 8.06555 0 A0A8C0PY24 A0A8C0PY24_CANLF PUM-HD domain-containing protein PUM3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] KELKQSRQL;SHLVLLAAF;VIQCYIQYGNE;VKGKKKFI 4 6.3 1.0037 -2.3931 0 0 0 0 0 7.30979 0 10.6947 0 5.2294 0 0 0 13.4135 0 A0A8C0PY85 A0A8C0PY85_CANLF Zinc finger and BTB domain containing 16 ZBTB16 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEEEEDRRARYLKNIF;HTGDHPYECEFCGS;RFLDSLRLRM;YSVLPNHK 4 7.5 0.94107 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4995 A0A8C0PY87 A0A8C0PY87_CANLF G8 domain-containing protein CEMIP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] EGESMPTFGKKFIGV;ERKFYFDSSTGLLFL;GIGLTFASDGSFPSD;KERHKNTFICFAVTSFSFF;PSKAETQRGDLSVISVNG;QDGGLLVFGDDKDG;TSAIGFLM 7 7.9 1.0026 -0.77124 9.02323 0 10.7262 6.67511 12.9195 0 0 0 10.4975 0 4.15413 0 5.83789 0 4.49044 A0A8C0PYE4 A0A8C0PYE4_CANLF Suppressor of cytokine signaling 3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein ubiquitination [GO:0016567] phosphatidylinositol 3-kinase complex [GO:0005942] 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] GCGSGRCA 1 2 1.0044 -1.1044 0 9.47322 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PYE5 A0A8C0PYE5_CANLF "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.17) (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (Glutamyl-tRNA synthetase) (Mitochondrial glutamyl-tRNA synthetase)" Canis lupus familiaris (Dog) (Canis familiaris) glutamyl-tRNA aminoacylation [GO:0006424] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] HLLLYQALGWQPP;LESGAAYPCFCSP 2 5 0.98907 -0.20294 0 0 10.8238 0 0 0 0 0 0 0 0 0 6.80826 0 0 A0A8C0PYE9 A0A8C0PYE9_CANLF Fatty acyl-CoA reductase (EC 1.2.1.84) Canis lupus familiaris (Dog) (Canis familiaris) long-chain fatty-acyl-CoA metabolic process [GO:0035336] peroxisomal membrane [GO:0005778] alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019] AGQTPQERVEEVI;ENLRDAVQLNV;NPFHWGEVEYHVIS;PAGGGGGA;RLHKAMVF;SPASGSLHGACFSLCLC 6 10.2 0.99027 -0.19842 0 0 0 0 0 0 0 0 0 0 0 0 9.61921 9.17193 0 A0A8C0PYF5 A0A8C0PYF5_CANLF Synaptotagmin like 1 SYTL1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] neurexin family protein binding [GO:0042043]; small GTPase binding [GO:0031267] AAPPCPASTPPRY;PGNHACPAGALP;SLGTGSSY 3 5.7 1.0021 -0.99424 8.46968 0 0 0 0 0 0 0 0 0 4.57277 0 5.40293 0 0 A0A8C0PYF9 A0A8C0PYF9_CANLF ADP-ribosylation factor GTPase-activating protein 2 (Zinc finger protein 289) ARFGAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] EPSKTEIQT;GVHLSFIRSTE 2 3.7 0.98798 -0.22462 0 0 0 0 0 0 0 0 10.7968 0 0 0 0 0 0 A0A8C0PYI2 A0A8C0PYI2_CANLF Ankyrin 3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] ETMTTTTIIEKHKMNV;GEGGVNGY;LQQGASPN;LVSFMVDARGGSMRGSRH;QYFAVVSRIKQESN;RRQSFASLALRKRYS;SDDEVRKANAPEMLSDG;SLEDSKLEDSMPL;VGLSKRSKVRVR;VTAEDTSLEDSK 10 6.9 0.94127 0.05044 0 0 0 0 0 0 0 3.46702 0 0 0 0 0 0 0 A0A8C0PYJ0 A0A8C0PYJ0_CANLF ATP binding cassette subfamily D member 3 ABCD3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LIERAFTYYKMGNLDNRI;LSHPRHLKSTHSELLEDYYQ 2 5.2 0.99218 -0.18421 0 0 0 0 0 0 11.2017 0 0 0 0 0 0 0 9.17582 A0A8C0PYL0 A0A8C0PYL0_CANLF G-protein coupled receptors family 3 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901] AITLVASGWVFVIF;ENTPNYFDTSQPRMRETAFEEDVQL;LILLVRLPFIKDK;PSAPFRSNVYQP 4 17 0.9876 -0.48179 0 0 0 0 0 0 9.41844 0 0 0 0 0 7.31651 4.77067 0 A0A8C0PYM2 A0A8C0PYM2_CANLF Dentin sialophosphoprotein DSPP Canis lupus familiaris (Dog) (Canis familiaris) DSDSSDSDSDSDSDSNSN;DSSDSDSSDSDSDSDSDSNSN;GADEDEDKGSGDDEG;GGGDDDSD;KVSEDKESKRQPGMA;NDSESDSEDSDSN;SESDSSDSDSDSSN;SKSDSSDSSSSSSK;SNGNDDADSEGDNNSD;SNSSDSSDSNSDSSDSDSSD;SSDSSDSSDSSDSSDSSDSD;SSNSDSNDSSDSSNSD;SSNSDSSDSSDSSDSDSKSDSSDS 13 19.8 1.002 -0.76805 7.66171 3.82161 7.97275 6.67158 0 0 10.4903 0 0 0 9.42047 3.83481 0 6.79948 6.96613 A0A8C0PYP3 A0A8C0PYP3_CANLF Peroxisomal assembly protein PEX3 PEX3 Canis lupus familiaris (Dog) (Canis familiaris) protein import into peroxisome membrane [GO:0045046] endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; protein-lipid complex [GO:0032994] lipid binding [GO:0008289] LMQQLNSESLT;MAEFFRPTEQ;QDLLMMEQVKDFAANVYEA 3 10.7 0.98554 -0.44962 0 0 10.1515 0 0 0 0 0 0 0 0 6.90219 0 0 10.068 A0A8C0PYQ4 A0A8C0PYQ4_CANLF Uncharacterized protein LOC606788 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLLLKILKPVNLLKLKKV;GLLLKILKPVNLLKLKKVQPL;ISALSWWQTAAKALCLS;KILKPVNLLKLKKVQPLPVLQFSFT;LKILKPVNLLKLKKVQ;LKPVNLLKLKKVQPLP;LLKILKPVNLLKLKKVQPLP;LLLKILKPV;LLLKILKPVNLLKLK;LLLKILKPVNLLKLKKV;LLLKILKPVNLLKLKKVQPLPVLQF;LNSGKNEEQF;PSSAMARNEPRE 13 5 1.0039 -1.0756 12.1631 10.0445 6.66434 0 5.11952 0 0 0 6.82909 0 4.05754 7.63662 9.79732 0 10.2544 A0A8C0PYT0 A0A8C0PYT0_CANLF Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) Canis lupus familiaris (Dog) (Canis familiaris) glutathione metabolic process [GO:0006749] mitochondrion [GO:0005739]; nucleus [GO:0005634] glutathione transferase activity [GO:0004364] LSTRRKLK;SLGLYGKDQQEAA;WKEEVVTMETWMK 3 16 1.0041 -1.1044 0 0 0 0 0 4.06195 0 0 0 0 0 0 0 0 0 A0A8C0PYT1 A0A8C0PYT1_CANLF Centrosomal protein 164 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] ANKKEVPENPVD;DEAKKEHTHLLESNQQ;EAEERKQRTELLGHLTRE;EANRKWLE;GAEPSAASARCEGTIGCALAAE;LDVDVLSP;MLEQLKEEME;QSVRSSSELLKNL 8 7.8 0.98712 -0.23387 0 0 0 0 0 0 10.8493 0 0 0 0 0 0 0 0 A0A8C0PYV5 A0A8C0PYV5_CANLF Coiled-coil domain containing 175 CCDC175 Canis lupus familiaris (Dog) (Canis familiaris) DLLKKKKHI;ELKVDLLKKKKHIPIKK;LENERLRKYIGYMKKKIEQYKKREE;LLKKKKHIPIKK;LLKKKKHIPIKKV;NELISEIGEIVE;QEQNLLSDYL;QSDYFKCNEEART 8 9.8 1.0024 -1.7475 0 0 7.09297 0 0 7.23199 4.7536 5.04522 9.68801 0 0 0 0 0 11.4227 A0A8C0PYW2 A0A8C0PYW2_CANLF Family with sequence similarity 189 member A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSALLPARPLLSLGLLQLI;SLIDYKSYMDTKLLVARFL;VLAPPPAL 3 7.6 1.0025 -1.005 0 0 0 8.55899 0 0 0 7.50985 0 0 0 0 0 8.00282 0 A0A8C0PYW4 A0A8C0PYW4_CANLF Ribosomal RNA processing 1B RRP1B Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] "nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" DIYLDELSKVGGKELLA;EDEMPENEV;KGIDRLRLGKYYMLIRLVLRQ;VQKRKRKKKKKNHL 4 8.9 1.0011 -0.95029 0 0 8.39 0 6.95245 0 0 5.04566 7.52066 0 0 4.81849 0 0 0 A0A8C0PYY5 A0A8C0PYY5_CANLF Fatty acid desaturase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] oxidoreductase activity [GO:0016491] LFFVEVCSAFSAEYAKYGHVKMHHG;PRGARPGRRGAQQ 2 8.2 0.98945 -0.21653 0 0 0 8.95463 0 0 0 0 0 0 0 0 0 9.62693 0 A0A8C0PYZ3 A0A8C0PYZ3_CANLF AAA+ ATPase domain-containing protein ATAD3A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EADAFLRKRAT;EENLRKQEES;KAERENADI;KPQDALEGVV;LALGVYSAKN;RFDLPGREERERLVRM 6 12 1.0034 -1.5479 0 0 0 0 0 4.17353 0 0 0 9.3206 0 10.726 8.93608 0 8.31936 A0A8C0PYZ8 A0A8C0PYZ8_CANLF Aldehyde dehydrogenase ALDH3A1 Canis lupus familiaris (Dog) (Canis familiaris) cellular aldehyde metabolic process [GO:0006081] cytoplasm [GO:0005737] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" EEVVYVLE;IACRRIAWG;LALYVFSLNDKM;VAYGGTGD 4 8.9 0.99817 -3.3166 0 0 0 0 0 0 8.08188 8.08576 0 0 9.69829 0 0 9.05523 0 A0A8C0PZ00 A0A8C0PZ00_CANLF Rho GTPase activating protein 17 ARHGAP17 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] KKKKKKKK;MRNPGISEWDHSHVYPRAKKKKKKK;PPQNFVNFRY 3 4 0.99645 -0.57592 7.56178 0 0 0 0 0 0 0 6.48033 0 0 0 0 0 0 A0A8C0PZ22 A0A8C0PZ22_CANLF Zinc finger CCCH domain-containing protein 14 ZC3H14 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] nuclear speck [GO:0016607] metal ion binding [GO:0046872]; poly(A) binding [GO:0008143] AYHHPVSP;FWLLPLSWFNEELPDYIM;HDGEEEEEDDDCG;HDGEEEEEDDDCGS;LPDYIMVMVANK;LPVVSSVVK 6 7.6 1.0026 -1.131 11.436 0 4.44374 0 0 0 0 10.4588 0 0 9.03628 8.22028 0 0 5.49496 A0A8C0PZ46 A0A8C0PZ46_CANLF Utrophin UTRN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane bounded cell projection [GO:0120025]; postsynaptic membrane [GO:0045211] actin binding [GO:0003779]; zinc ion binding [GO:0008270] AAEIKGYKK;ELERIIADLEEEQRN;EQMLHQPM;ISELDDANLQVE;KKECEEGEIS;LDQLSEIGQDVGQLVDN;LEQPESDSRINGVSPWASPQ;LLGDLDVEISWAK;LQESLGELDKQLTTYLTDRIDAFQ;LYTLAEETKALEK;PHDTSTDLTEFM;SFAALNRTGEGIVQKLSP;TESSAALQNLIE;TSEGLLGDLDVEISW;VCRWTEERWSRLQEINILWQ;VLKNKFRSKKY;VLQRGEQML;VQRLEDSSNQV;VVLMNARGGSSR 19 7.2 0.99662 -4.3124 0 3.55041 9.03141 11.0555 0 0 8.54605 10.4439 0 9.20073 9.3999 12.7586 0 10.3073 0 A0A8C0PZ48 A0A8C0PZ48_CANLF Outer dynein arm docking complex subunit 1 ODAD1 Canis lupus familiaris (Dog) (Canis familiaris) EHSAGSACSEDGSDAFL;ESHSGAES 2 3.6 0.98719 0.046227 0 0 5.49736 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0PZ87 A0A8C0PZ87_CANLF KH homology domain-containing protein 4 (Brings lots of money 7) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] LDAAAAVA;PPVPTQYPITQ;PVKKMKTAEKGF 3 5.2 1.0027 -1.3547 0 0 12.9717 12.5457 12.614 12.6387 0 0 0 13.2171 0 13.8281 13.8492 13.9633 13.9528 A0A8C0PZ93 A0A8C0PZ93_CANLF "Ciliary rootlet coiled-coil, rootletin" CROCC Canis lupus familiaris (Dog) (Canis familiaris) LYSLCPTPPPRANL;QNLEKDQVNKVL;QRESSTREAEELRTQLRL;QTLRDLAQAVLSDVD;VLDASEGRTIKL;VLSLQEEN 6 4 1.0029 -0.78993 0 0 0 0 0 6.88264 6.03617 10.3281 0 0 0 0 0 0 10.2286 A0A8C0PZ94 A0A8C0PZ94_CANLF SOCS box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] APAADKEPAEVQFCE;AYYGQLSCLKTL;DVNDRRSSALYFAV;FDVNDRRSSA;GVSPLHLAAERNHDAVLQA;LDLLPLPG;SSRFSDAPAA;VGKHRIKLLDLLPLPG 8 13.7 1.0043 -2.0187 9.96953 0 0 4.90607 0 0 9.81606 0 0 11.9048 0 0 0 9.65285 0 A0A8C0PZ96 A0A8C0PZ96_CANLF Myosin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AGDAERSQAASALSRART;ATFEELCHNYAHERL;EAGGLLSGTSALRSC;EEVVSSDS;FSSCESLFESGQNVG;KDKESVLPSKAEK;MRIEYLEQ;PAHLGSLAK;PATDPGGEKKGGTPGTPRGPQ;PLGLEDWPTLPIYQTTG;RFAMVMSLDFNATGRVTAAQLQ;SLATDTMRSPSR;SPLCLRRQKYYH;SPQRSRIHFETE;VLESERAERQRAFREV 15 8.4 0.99723 -3.7293 0 10.5911 9.19365 5.07724 10.2426 9.0292 7.07478 0 6.52213 10.6602 0 9.17375 0 0 0 A0A8C0PZ97 A0A8C0PZ97_CANLF dual-specificity kinase (EC 2.7.12.1) Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] GLAARTMPHPRRYHSSERGSRGSY;RARPGGGAGKWRGR;SRSSYDDRSSDRRVYDRRY;YVGFTLFQTHDNREHLAMMERILG 4 12.8 0.98853 -0.50654 0 0 0 0 0 6.95641 0 9.87518 0 5.07968 0 0 8.72962 8.94901 0 A0A8C0PZ99 A0A8C0PZ99_CANLF Tyrosine-protein kinase (EC 2.7.10.2) YES1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; signaling receptor binding [GO:0005102] GVTPFGGASSSFSVVPSSYPAG;VPSSYPAGL;VSTSVSHYGT 3 6.7 1.0021 -1.0159 0 0 0 0 4.00279 0 0 0 0 0 0 0 8.03419 0 0 A0A8C0PZD2 A0A8C0PZD2_CANLF Dedicator of cytokinesis 8 DOCK8 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] ADARSGKNRANGSDE;DLRSLQPD;GQYHRQSISTSGFPSLQ;PLTACGFDLRSLQP;PSISSQNSSSCSSFQDQKIA;QSRRLSERALSLED;RILVKVLTLKFEIEIEP;SLVGKAPDFNEE;VEVIKDSTPVD;VKVKIAALYLPLVGIIL;VTYFEKNFNLRRFMYT 11 7.7 0.99825 -0.60378 0 0 0 9.00815 0 4.7822 10.6917 0 10.9553 9.11009 8.78601 9.13825 13.5699 10.4354 0 A0A8C0PZF1 A0A8C0PZF1_CANLF Huntingtin MSANTD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] IPVEFLQEKEVFKE;LAGGGSSC;LQDIGKCVEE;QLKTNLTSATK;QQPPPPPPPQ;SRTQFEETWATL;VISDYLLSN;VLECDLLDETAKQL;VLPDTQPP;VVMTLEALAWHLIHEQIPLSL;VYLKLLMHEAQP;YWSKLNDLFGDAVLYRS 12 4.9 0.99681 -4.2063 9.56822 12.3475 0 0 9.09381 9.90162 10.3493 8.64825 9.44079 0 4.97104 0 10.2692 9.46544 7.44667 A0A8C0PZF3 A0A8C0PZF3_CANLF NHS like 1 NHSL1 Canis lupus familiaris (Dog) (Canis familiaris) AHGALGTARGC;DNFKALLLK;ELRHFENVI;GFRQPCNKEEGGR;LCDDYQDEDEETDQ;PNVYSLCGATP;QEGSRTQVPGG;SPLCDDYQDEDEETDQKCSVSS;SRKPPPISKKPKLFLVVPPPQRDLT;TDTLVRRPKKVKRRKT;VISPACVVSPHA 11 8.8 1.0027 -1.1283 0 5.03139 0 0 8.90084 9.47421 9.71055 0 8.14975 17.0295 3.76575 0 2.38965 11.5149 0 A0A8C0PZF6 A0A8C0PZF6_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] AGVPAPPA;DDVTVYLFDQE;DESDEELRCYSIQE;GGGGGGPG;GVPPARNSPPRGAPQP;GVSGGAGS;KNPYRDSAYF;LLSEAFCEDLERK;PEEEEEDSEDSDESDE;TPVPPAPP 10 5.9 1.0029 -2.4629 0 11.3771 4.26589 0 0 0 0 0 11.6967 0 0 6.38548 0 0 0 A0A8C0PZJ0 A0A8C0PZJ0_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GGGLDFEE;GVNSLQQYYLNPNP 2 2.4 1.0022 -1.0145 0 0 0 8.94263 8.69502 10.8859 0 0 0 11.2224 0 7.2148 0 0 0 A0A8C0PZK7 A0A8C0PZK7_CANLF BRO1 domain-containing protein PDCD6IP Canis lupus familiaris (Dog) (Canis familiaris) multivesicular body sorting pathway [GO:0071985] FPFSENQICLTFTWK;LHLLCFQQIELLLLLLR;LSKLRRAA 3 4.5 0.98697 0.046227 0 0 0 0 0 0 0 0 0 0 5.05402 0 0 0 0 A0A8C0PZM7 A0A8C0PZM7_CANLF Microtubule-associated protein 10 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule binding [GO:0008017] LELNVLDSSTSDHFEEEDEV;LQLPPGRPTPAPQ;QCRDICELVI 3 4.7 0.9873 -0.50116 0 0 8.91806 0 0 0 0 0 8.5142 6.16794 0 0 0 0 7.00146 A0A8C0PZN1 A0A8C0PZN1_CANLF Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) EPB41 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; structural molecule activity [GO:0005198] AAVDSDRSPRPTSA;DITRYYLCLQLRQ;HQQQKEEGEGVTNSGQQETQ;LVQDEEKIKRKERSA;QDIVSGRLPCSFATLALLGSY;QKSIRRHRN;TEDITRYYLCLQLRQD;TETKTITYE;VPWNFTFNVKFYP 9 13 1.0019 -1.803 0 0 0 0 10.1325 8.70131 8.42991 9.64947 9.44388 0 0 0 0 0 0 A0A8C0PZQ1 A0A8C0PZQ1_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HERC2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AADDSSDDSENE;AADDSSDDSENEDV;ADDSSDDSENEDVDSFA;EALQRQFEYEDPIVRGGK;FIPVTDDPGAASII;FKLLSSLPRWRRIAQKIIRERRKKR;GVTCDGCQMF;HYSYNEEKDEDHC;IDIGEPLTDCLKDVDLIPPFN;KCRNCDDFDFCET;LMADSEHM;LPRWRRIAQKIIRERRKKRV;PGMLLDSWSRMVKSL;PIIALRNRLLLLHHISEL;QCEGLANL;RGLPVRTD;RIPGDELKW;RRIAQKIIRERRKKRVPKKP;SIGLRVPFV;SLFLRFVWGRT;TTCSSDIP;VGESVDDCGGGYSESI;WGKQPDVNELKECLSVLVKEQQ;YAIHFCKSIDTDD;YGKLGRGGSD;YKWGSVTHQSVG 26 6.4 0.99697 -5.9218 13.194 13.018 0 10.6466 10.0119 14.9869 8.93106 0 9.33316 13.169 13.2 0 13.7009 10.6281 13.5881 A0A8C0PZQ8 A0A8C0PZQ8_CANLF Solute carrier family 7 member 14 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] amino acid transmembrane transporter activity [GO:0015171] LLALVIAVIVTIIVALGVKN;QENWGGPAEDKGFYYQ 2 4.9 0.9401 0.10131 8.51586 0 5.35456 0 0 0 0 0 0 0 0 0 9.35218 0 0 A0A8C0PZR2 A0A8C0PZR2_CANLF "Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) ribosome [GO:0005840] GEDDLMPVYHGNE;GEDDLMPVYHGNEV;GEDDLMPVYHGNEVTPAEAAQA;VGEDDLMPVYHGNE 4 6.1 0.98474 -0.2415 4.21304 4.46048 15.1449 12.6328 12.8292 13.041 0 0 6.69139 15.4166 4.35819 14.523 15.2495 15.0107 20.0896 A0A8C0PZS6 A0A8C0PZS6_CANLF Scavenger receptor class B member 1 (SR-BI) SCARB1 Canis lupus familiaris (Dog) (Canis familiaris) caveola [GO:0005901] GTFQGIPTYRFV;NPPVQNVR;PVQNVRIDPNSLSFN;WNGLSKVNFWHSDQCN 4 6 0.98788 -0.4691 0 0 0 0 0 0 0 0 6.22982 0 0 0 10.6778 0 11.555 A0A8C0PZT7 A0A8C0PZT7_CANLF Agrin AGRN Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; receptor clustering [GO:0043113] basement membrane [GO:0005604]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; laminin binding [GO:0043236] AGPCEQAECGSGGSGSGED;CPSSCQCNPHGSYSGT;DCEQMTGLCSCKPG;DTDLFVGGIPEDQASVVLERTSI;EEVEHCVE;GEDGECEQELCQQH;GHCQTCGDTV;GVTYGSTC;LADFHGFSYL;PCLGVRCPFGATCAV;SEVKKDFRSV;TCVRSADGQTATCLCPATCRGPP;VEGQELFYT;WNFRGIVTDGRSGCTP;YLNAVTESELTNEIPAE 15 10.2 0.99118 -0.27216 0 0 0 0 0 8.53768 0 0 0 0 0 0 0 0 0 A0A8C0PZU0 A0A8C0PZU0_CANLF HtrA serine peptidase 3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] ECARGVCRCRWAHAVCG;GLRDSDMDYIQTDAIIN;SLVEELKASNPDFPSVSSGI 3 12 0.99496 -0.010626 0 11.4894 0 10.3018 8.81054 0 0 0 0 0 0 0 0 0 0 A0A8C0PZU4 A0A8C0PZU4_CANLF Eukaryotic translation initiation factor 4 gamma 3 EIF4G3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] AAAAAAAAAAAAAPPHPN;EQDKMSQGFHPG;ESLECLCRLL;EVLPLTLE;KLLLNRCQKEF;LLDFQYMP;PGPPTPSPYSAHEIN;QPGQRREPRKII;QYFNQMEKIVKERKT;SETLPATESIVE;VEENGEEAEP 11 7.2 1.0012 -2.7089 8.21057 8.71778 9.8269 0 0 0 11.0866 12.0069 10.8148 0 8.13098 0 0 12.8647 0 A0A8C0PZV4 A0A8C0PZV4_CANLF Vacuolar protein sorting 13 homolog A VPS13A Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid droplet [GO:0005811] CEICWKGDLE;CVEDDSEEEYFDAPCSPLE;DDSEEEYFDAPCSPL;DFDFSAPKINLDVELHD;DVSIVMRS;IDNFQAAKQALAEA;IPWKNLYTQPVEAVLGDI;IVFVADMTRSD;IVTFTPFYMIENKS;KPIYLVTTLDNTM;LEEPNEVENKAPTTEL;LNDYDESLDSLKNG;LNHDWKSEYHIKPNQ;LPYRIAYYIEGT;PVQIKNHFSVPLS;SPSEDKVIELDTNIPVRFTP;TGTAVETSVQTW;VLIQEMDLRLDLGFVYA;YDFVFRPIS 19 8.2 0.99894 -3.2501 8.78891 0 7.05767 10.5084 0 0 5.6014 13.6307 7.02414 10.3224 7.30898 0 9.12738 8.953 3.80622 A0A8C0PZW9 A0A8C0PZW9_CANLF DS cell adhesion molecule like 1 DSCAML1 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] axon [GO:0030424]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632] AGVLNCSVDGYPP;ALLFIVRKKRK;DGEWGEMQN;EVYTLDNLKKFAQYG;GVALLFIVRKKRK;GVTIESKEFMSSL;HHGGLYIS;HPGAPAAA;IVEMKATGD;IVRKKRKEKRLKRLRDAKS;KRKEKRLKRLRDA;LGVALLFIVRKKRKEKRLKRLRD;LKCGTWYKVKLAAK;LSVTDPAESI;NSSGEVFLTELREATWYELRMRACN;PEDVGTSLYFVNDSLQ;QEYVSVVSW;STEEAAPDGPPMDVTLQPV;TLGVALLFIVRKKRKEKRLKRLRD;TVIDPLHVTLTPKKLKTGI;VALLFIVRKKRKEKRLKRLRDA 21 10.4 1.0035 -2.2384 0 9.47847 7.06609 8.54094 10.4464 9.51082 13.2398 9.64913 0 5.47768 7.67532 0 5.69619 6.88704 0 A0A8C0Q003 A0A8C0Q003_CANLF Kv channel-interacting protein 4 KCNIP4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] cytoplasm [GO:0005737]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459] KMDKNKDGVVTIDEFIE;PLPFNPPSPPLSLLLPPPL;SPSAPLPFNPP;WAPGPGGG 4 8.9 0.9917 -0.13318 0 0 9.92403 0 9.66521 0 0 0 0 7.81583 0 0 0 0 0 A0A8C0Q016 A0A8C0Q016_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ENDILDQFVN;KEEQRRKKKRLKKR;QRRKKKRLKKRIF;QRRKKKRLKKRIFAAV;SKPMDSNIRQCLSGNCDDMDSPQ;VLKFLFVYIV;YSVMIQKVILHD 7 9.4 1.0004 -0.61949 0 8.14883 0 0 6.33409 0 6.54685 8.34367 0 0 6.53863 0 0 0 0 A0A8C0Q035 A0A8C0Q035_CANLF RNA terminal phosphate cyclase like 1 RCL1 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254]; RNA processing [GO:0006396] nucleolus [GO:0005730] catalytic activity [GO:0003824] LVAETTNGTF;SPAGTSLSLHV;VLSTLSGRPV 3 7.5 1.004 -0.83192 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7148 A0A8C0Q048 A0A8C0Q048_CANLF RING-type domain-containing protein PCGF3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] APGVRTQELCLAW;NGETKADDSSNKEAAE;RNGETKADDSSNK;VGSHVTGKEADSPEASSP;VGSLGAGH 5 20.6 0.99162 -0.51176 0 0 0 0 6.49233 0 10.8852 0 0 0 0 0 0 9.30115 0 A0A8C0Q061 A0A8C0Q061_CANLF PWWP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] GGGGGGGD;PDREPLKLEDPDGGGGGG;QPPPRTIKRT;SSDSLDESKSSSSEVTSPDTCD 4 9.3 1.0044 -1.0978 8.01992 0 0 0 0 0 0 0 0 0 0 0 0 11.8738 10.0736 A0A8C0Q078 A0A8C0Q078_CANLF Metaxin-1 (Mitochondrial outer membrane import complex protein 1) MTX1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] SAM complex [GO:0001401] GAVLLVGG;VTALSLREEGPAD 2 4.2 1.0024 -1.3911 0 0 0 0 0 0 6.84725 0 0 0 0 0 0 0 0 A0A8C0Q0A7 A0A8C0Q0A7_CANLF Paraneoplastic antigen Ma-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPAEKQSKAGEDKRGKRKHK;GATAGAGA;GIPEDCDH;KAGEDKRGKRKHK;PGAGATAGAGAVGAPPPD 5 10.5 1.0029 -1.6317 0 9.28415 9.02453 0 0 0 10.6015 9.62806 0 0 10.8221 0 0 0 0 A0A8C0Q0B3 A0A8C0Q0B3_CANLF Tetraspanin TSPAN15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGQGAGSE;TGKRFACEAL 2 5.9 0.99116 -0.27552 0 0 0 0 0 0 0 0 9.11754 0 0 0 0 0 0 A0A8C0Q0B4 A0A8C0Q0B4_CANLF Transmembrane p24 trafficking protein 7 TMED7 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] LEQVPQAP;NRVSALTQMESACV 2 6.2 0.99465 -0.11795 12.2161 0 12.2556 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q0C0 A0A8C0Q0C0_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DENDNDPE;EGARISLDPATDP 2 2.3 1.0042 -1.0447 4.58982 0 0 7.80697 0 0 0 0 0 0 6.93357 0 0 0 0 A0A8C0Q0D3 A0A8C0Q0D3_CANLF PX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768] phosphatidylinositol binding [GO:0035091] DTKLPSWQRAACL;FLRQLPFRGDDGIFDDNFIKERKQG;TPGVFLFHRPVLPGKAFLRQL 3 42.5 0.99247 -0.16905 0 0 7.58323 0 0 0 0 0 0 0 6.39374 0 0 9.97857 0 A0A8C0Q0E3 A0A8C0Q0E3_CANLF Potassium channel domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] RWTTRALRRRVRRLRGRHRSACA;VRRLRGRH 2 5.5 0.99008 -0.21967 0 0 0 0 0 0 0 0 0 10.6373 0 0 0 0 5.4722 A0A8C0Q0E6 A0A8C0Q0E6_CANLF Niban apoptosis regulator 1 Canis lupus familiaris (Dog) (Canis familiaris) HYGSWEMITGDEVQVT 1 5.5 0.9614 0.049233 0 0 9.61368 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q0H6 A0A8C0Q0H6_CANLF Glutamate decarboxylase 1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] GCERDQELQKIAPKIKAQ;SRVYLPTRDSMWMNTNKNFNH 2 6.9 0.97774 0.047716 0 0 0 0 0 0 0 0 0 0 5.42844 0 0 0 0 A0A8C0Q0I1 A0A8C0Q0I1_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein-disulfide reductase activity [GO:0015035] NGAGVLGSS 1 2.4 0.98455 -0.25303 0 0 10.1906 10.7262 10.8503 0 0 0 0 0 0 10.8369 0 11.1198 0 A0A8C0Q0M7 A0A8C0Q0M7_CANLF EF-hand domain-containing protein EFHD2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] LSFREFLLIFRKA 1 5.4 0.93761 0.059566 0 0 0 10.8684 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q0M8 A0A8C0Q0M8_CANLF Dishevelled binding antagonist of beta catenin 3 DACT3 Canis lupus familiaris (Dog) (Canis familiaris) GLCELHWLRERQ;GRVGPLGRRGPAGGVG;PEPPVERAGGRP;PGGGAGGG;RGWAAQWAGAYA;TAASGPGGGAGG 6 9.5 0.99371 -0.022623 0 9.48172 0 5.7995 8.78992 6.50957 0 0 0 0 0 0 0 0 8.50779 A0A8C0Q0N7 A0A8C0Q0N7_CANLF EGF-like domain-containing protein LRP8 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] CDEDDDCSDNSDE;CDEDDDCSDNSDEDD;CDEDDDCSDNSDEDDC;CDGDDDCGDGSDERGCAD;CDGDDDCGDGSDERGCADPA;CDGEEECPDGSDESEAT;CDGEEECPDGSDESEATCT;CDGEEECPDGSDESEATCTKQVCP;DDDCGDGSDERGCADPACG;DDDCSDNSDED;DDDCSDNSDEDDC;DEDDCPKKTCADSDF;DEDDDCSD;DEDDDCSDNSDEDDCPKKTCAD;DEPLKECVPPT;DGDDDCGDGS;DGDDDCGDGSDE;DGDDDCGDGSDERG;EDDDCSDNSDED;EDDDCSDNSDEDD;EDDDCSDNSDEDDC;EDDDCSDNSDEDDCP;EDPDACSQICVNYKGYFKCECHPGY;FVCDGDDDCGD;IPSVWRCDEDDDCSDN;LLLLLLLP;LLLLLLLPLRLQ;LLLLLLPL;PVLLLLLLLPLR;PVLLLLLLLPLRLQHL;RCDEDDDCSDNSDEDDC;RCIPSVWRCDEDDDCSDNSDEDDC;RPLAPPVLLLLLLLPLRLQ;VCDGDDDCGD;VLLLLLLLPLRL;VWRCDEDDDCSDNSDEDDCP;WRCDEDDDCSDNSDEDDCPKKTCAD 37 14.6 0.98809 -0.46538 4.9507 7.15735 7.1014 7.73118 9.66039 6.8495 7.55605 9.73836 8.97441 6.27497 7.22072 6.15874 8.17827 3.1812 8.8649 A0A8C0Q0P2 A0A8C0Q0P2_CANLF Coiled-coil domain containing 84 CENATAC Canis lupus familiaris (Dog) (Canis familiaris) IKEVRSETHLFFL 1 4 0.99323 -0.14992 0 0 0 0 0 0 0 0 0 0 0 0 12.0489 0 0 A0A8C0Q0Q6 A0A8C0Q0Q6_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FVGMDGVRAFLQ;VIVLLALRLRRWHASRLL;YSVPEELE 3 3.9 0.98507 -0.25922 0 0 11.09 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q0Q9 A0A8C0Q0Q9_CANLF 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) DPH1 Canis lupus familiaris (Dog) (Canis familiaris) protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] AACDGCNC;ACDGCNCG;SIDWGTAFPKPLLTP;SPVAACDGCNCGD;VDDFTARALGADF;YPMDFYAGSSLG 6 12.1 0.99947 -2.8891 6.97258 8.99438 9.29407 10.2621 0 0 9.3493 10.5091 9.84714 9.45148 9.69909 9.10588 8.4195 9.52025 9.33798 A0A8C0Q0R0 A0A8C0Q0R0_CANLF PIN domain-containing protein SWT1 Canis lupus familiaris (Dog) (Canis familiaris) APCSSASLE;HKKFRDSSEKCVLE;LQEASYSSVNQIIS;LVEMEYSMQ;SKEELSAELLN 5 6.8 1.0023 -0.72308 0 0 10.5811 8.22352 11.4509 0 0 0 8.88938 0 0 0 0 0 0 A0A8C0Q0R6 A0A8C0Q0R6_CANLF Zinc finger FYVE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872] ALKGKYIE;ASSETCYET;EQDYVQDEQNAFGSNH;IDKNVCNKISLLPNDEDSLP;IYQTQANSATGHPRKV;LQKDQQCINCCAS;LVEEEVDVAV;RHHCRACGKVFCGVC;YSSLTCLPVPSLCGSLIE 9 8 1.0029 -1.3459 5.5127 0 0 4.40919 8.1281 0 8.98222 0 7.69537 0 0 0 10.4982 0 12.0616 A0A8C0Q0S6 A0A8C0Q0S6_CANLF Transmembrane channel-like protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] AIATLKFII;AIATLKFIII;KPTSYSSQ;LLTKYNITNST;LVIFLIIFMLVLLPVLLTKYNI;VTSEAFAVPFFMI 6 8.3 0.9986 -3.0153 0 0 5.72887 0 0 0 0 9.81909 5.00504 0 5.95671 0 0 0 9.70663 A0A8C0Q0U2 A0A8C0Q0U2_CANLF ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) SIRT7 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylethanolamine biosynthetic process [GO:0006646] ethanolamine-phosphate cytidylyltransferase activity [GO:0004306] GVRRRGGSEPGLS;PLGQVRVRYWPR 2 3.1 0.98382 -0.25352 0 0 0 0 0 0 0 0 0 0 0 0 0 5.89714 0 A0A8C0Q0V0 A0A8C0Q0V0_CANLF "Troponin I1, slow skeletal type" TNNI1 Canis lupus familiaris (Dog) (Canis familiaris) troponin complex [GO:0005861] actin binding [GO:0003779] AKECWEQEHEEREAE;RKPKITASRKLLLKSL;VEVVDEERYD 3 39 0.96169 0.049233 0 0 0 0 0 4.37219 0 0 0 0 0 0 0 0 0 A0A8C0Q0V7 A0A8C0Q0V7_CANLF CEP170 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814] ADFSIHFNRFNPDGEEED;AIVMEERKPLST;EEIARISQDLALIAREIND;EPSVSIPFLQTAL;FFFFCFICFRQ;PGSAIDTREELVDRVFDESL;RRSYSFTQSAGILCQETTYST;VEARKMIDKVFGVD 8 8.5 0.98981 -0.53303 0 0 0 8.52841 0 0 10.9332 12.0931 13.7077 4.03606 0 0 8.27104 4.58033 0 A0A8C0Q0X7 A0A8C0Q0X7_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] APLFQWLVSLYAW;PHFCSLASTSKPQDRIRE;SEGKGAAG 3 8.2 0.99471 -0.15545 0 0 0 0 0 5.54693 0 0 0 0 0 0 0 9.6974 9.4939 A0A8C0Q0Y2 A0A8C0Q0Y2_CANLF Protein kinase domain-containing protein LOC489591 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ESEEEEEEEEET;FLPEAESGSGSEEEEEEEEEE;GVKHLHDNWILHR;LSPIELKQELPKYLPAL;PVKEEKMEERDLL;SEEEEEEEEETG;SGSEEEEEEEEEEEEEEEEEGS 7 11.5 0.98787 -0.3404 0 9.0316 0 0 8.46544 0 0 6.74537 0 0 3.72181 0 6.00513 6.21045 0 A0A8C0Q0Y5 A0A8C0Q0Y5_CANLF Ferroptosis suppressor protein 1 (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (p53-responsive gene 3 protein) Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886] oxidoreductase activity [GO:0016491] GVGQISGFYVG;PGPPSGAGG 2 2.5 0.99469 -0.56056 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1242 A0A8C0Q0Z7 A0A8C0Q0Z7_CANLF Transmembrane protein 121 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGLTFFYCYMLLLVL;TRAAGRNHFRSI 2 4.3 0.9848 -0.24044 0 0 0 0 0 9.04308 0 0 0 0 0 0 0 0 0 A0A8C0Q100 A0A8C0Q100_CANLF Myb-like domain-containing protein MIS18BP1 Canis lupus familiaris (Dog) (Canis familiaris) DDHDDFFSTT;ESSNSTYLPIKQ;SGRFDPDVQKSSKSN;VTSDSKKNTRLLPKLK 4 5.3 0.99288 -0.16656 0 0 0 0 0 0 0 0 9.21624 0 0 7.83042 9.60103 0 0 A0A8C0Q130 A0A8C0Q130_CANLF LIM homeobox 6 LHX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" HYSPFSSPERAR;PDAQTLQKLADMT;PDRLWLDPWAWPSLLL;PFTRCPDRLWLDPWAWPSLL 4 10.2 0.94975 0.056243 0 0 0 0 0 0 10.6271 0 0 0 0 0 0 0 0 A0A8C0Q146 A0A8C0Q146_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLAHIPGFLQ;VHSGHAWGLAHIPGFL 2 7.5 0.98981 -0.21262 0 7.76759 0 0 0 0 9.01915 0 9.21519 0 0 0 0 0 0 A0A8C0Q148 A0A8C0Q148_CANLF RNA 2-O ribose methyltransferase substrate binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] cytoplasm [GO:0005737] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] GLGWVTRPLLS;SYDLDWTEAPAAVVIGGE 2 6.9 0.94244 0.083804 0 0 0 0 0 0 0 0 8.90506 0 0 0 0 10.2557 0 A0A8C0Q150 A0A8C0Q150_CANLF Heat shock 70 kDa protein 14 MSANTD7 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] DVRGNARAMMKLMNSADIAKH;GSISSVCLELYESEGKNS;PSAALLAYGIGQ 3 10.7 0.99369 -0.05437 8.86171 0 0 14.4335 0 7.44989 0 14.8379 0 0 0 0 0 0 0 A0A8C0Q151 A0A8C0Q151_CANLF Laminin subunit alpha 1 LAMA1 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] ASSDLNRLDKDPI;CNCSASGSMSDDCTEDGQCHC;DQLEDVAEQTDN;DTGLGCLPCNCSASGSMSDDC;EDLLLQIQKNCQE;GATCDQCEDGYW;ILKKSQDLMTF;LAALGRHGEKQGHL;LPPEPQPLPSL;LQLHGGYLHFMFDLG;PDCVACDCDL;PESELLATFATKNSSG;QYCERCSSG;RFQEDVDTI;SDCVSCDDEC;TCGESCSRCCPGYHQQP;VTQIIMLFSTFSPN;WHTVKTEHFKRKGFMTVDGQESP;WNYIEREGRCHGCFGSPQ;YGNPTVPGESCV 20 8.7 0.9985 -3.0077 8.99661 0 13.6951 11.3541 9.00273 11.1384 8.40752 12.2557 10.1818 8.51743 9.62866 8.25167 0 13.5868 0 A0A8C0Q163 A0A8C0Q163_CANLF Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] fatty acid elongase activity [GO:0009922] AFQKYLWWKKYLTSLQLV;LDTIFFVLRK;VTSLGPKL 3 13.3 0.97986 0.048313 0 0 0 0 0 0 0 0 0 0 5.95184 0 0 0 0 A0A8C0Q179 A0A8C0Q179_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVSKIYKELIKIFLFLNF;MDAFLESHKL 2 3.9 0.97284 0.048313 0 0 0 0 0 0 0 0 4.39739 0 0 0 0 0 0 A0A8C0Q184 A0A8C0Q184_CANLF Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (Transglutaminase-1) TGM1 Canis lupus familiaris (Dog) (Canis familiaris) keratinization [GO:0031424] membrane [GO:0016020] protein-glutamine gamma-glutamyltransferase activity [GO:0003810] DELIIRRGQPFHMVLHFS;DIVYVDHEDWR;GKGGSGGWKAQVTKASGQN;IVYVDHEDWRQ;PFHMVLHF;SEAGEFQLPFDP;SGIFCCGPCSVESIK;SNAGGNSP;WNFHVWNDCWMK;YGQFDHGVLDA 10 14 0.99947 -2.8615 11.5018 12.1 11.6551 10.0796 11.6445 8.6616 10.1288 13.131 14.7937 0 0 8.6034 9.53403 14.0488 0 A0A8C0Q191 A0A8C0Q191_CANLF WD repeat domain 25 WDR25 Canis lupus familiaris (Dog) (Canis familiaris) DVVKPPGQ;LVAYDDSESEAE 2 7 1.0021 -1.4177 0 0 7.52144 0 0 0 0 0 0 8.00433 0 0 0 0 0 A0A8C0Q1A5 A0A8C0Q1A5_CANLF Protein NDRG3 (N-myc downstream-regulated gene 3 protein) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] NQQSCFLGCLSSDLQEITQHF 1 10.4 0.97803 0.047632 0 0 0 0 0 0 0 0 0 0 0 0 0 6.0708 0 A0A8C0Q1B7 A0A8C0Q1B7_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] membrane [GO:0016020]; synapse [GO:0045202] transmembrane transporter activity [GO:0022857] DRKAEEEELAQQ;ESDTGTWYRRCFVRIRTELYGI;GVEVFVVGFV;GVLCLYNGLTISAWNSL;PPGETYDGEANDDEGSSE;YPPGETYDGEANDDEGS 6 11.5 0.99354 -0.058091 0 0 0 5.48249 0 7.58436 11.7948 0 7.69933 0 0 0 0 0 0 A0A8C0Q1C9 A0A8C0Q1C9_CANLF WH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020] actin binding [GO:0003779] EATSLPLSGVTSELPPT;NILAQIRKGVKLKKVQ;RGKLESSQKTEAQSLAQL 3 5.5 0.8681 0.14377 0 0 0 0 9.1601 7.72608 0 0 3.97966 0 0 0 0 0 0 A0A8C0Q1D2 A0A8C0Q1D2_CANLF "RNA transcription, translation and transport factor protein" RTRAF Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" tRNA-splicing ligase complex [GO:0072669] RNA binding [GO:0003723] IWLMTEILR;NIHSSDWPKFFEKYLRDVNCPFK 2 13.7 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 0 8.5411 0 0 0 0 A0A8C0Q1D3 A0A8C0Q1D3_CANLF Dishevelled associated activator of morphogenesis 1 DAAM1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] EQAEKMRKEH;QKYASERTRFQ 2 2.1 0.98831 -0.4907 0 0 0 0 9.34058 0 0 0 0 0 0 10.3301 0 0 9.59302 A0A8C0Q1E2 A0A8C0Q1E2_CANLF NXPE family member 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IKILIIRNMANRKSLLVLLFLLASW;LDKNINIQWQKHGYPLIGSLTYSVK 2 8.3 0.93789 0.071076 0 0 0 0 4.70548 0 0 0 0 0 0 5.03029 0 0 0 A0A8C0Q1F2 A0A8C0Q1F2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IEGTILDILKVIY;LNDALDQMDFTDIYRT;MDAFLESHKL;MNEKGEITTNT 4 6.8 0.99263 -0.19284 0 0 0 0 0 9.36337 0 0 0 7.20877 0 0 0 0 0 A0A8C0Q1G0 A0A8C0Q1G0_CANLF Zinc finger and SCAN domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ECKECGESFSY;GFSNSSNFITHQRTH;GKSFSRSSNLATHRRTHL;QCDWESDHERDCGSR;SQLVVHQRTHTGE;THERTHTGEKYYKCNEC 6 14.5 0.98518 -0.25922 0 0 5.89135 4.00818 0 0 11.7133 0 0 8.76431 0 0 0 10.4428 0 A0A8C0Q1H1 A0A8C0Q1H1_CANLF G-protein coupled receptors family 1 profile domain-containing protein LRRC20 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] PSQPPNSSWPPSQN;SGPGGSCA 2 4.4 1.0044 -1.1044 0 0 0 10.5342 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q1I1 A0A8C0Q1I1_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EEGEPFSQEEMEEML;RALFSVVSP 2 16.1 0.98434 -0.24269 0 0 8.10648 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q1J1 A0A8C0Q1J1_CANLF Protein kinase domain-containing protein ANKK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ADANLADEEGWAP;DIRDGVGCTPLQ;SPSPSHPVPTGPRS;VNLMRRCWDQDPKKRPCFPDI 4 7.3 1.0009 -0.63006 0 10.9099 0 0 0 0 0 0 0 0 10.4462 0 0 0 0 A0A8C0Q1J2 A0A8C0Q1J2_CANLF Rieske domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; ubiquinol-cytochrome-c reductase activity [GO:0008121]" AEPFLFFFFFLRFYLFISET 1 5.7 0.96581 0.048658 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.27102 A0A8C0Q1J4 A0A8C0Q1J4_CANLF Ral guanine nucleotide dissociation stimulator Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] ATVTQFNSVANCVITTCLG;DEDGGPQD;ESYNLSCELEPPSES;QGRQEGKEHLAP 4 6.9 1.0018 -1.4338 11.442 0 6.61347 0 0 8.99005 0 10.3107 0 0 0 0 0 0 0 A0A8C0Q1M0 A0A8C0Q1M0_CANLF "ATP synthase subunit e, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] AEEKKQQEERKRIEREL;RIERELAEDDSI 2 33.3 0.93131 0.096667 0 7.17782 0 0 0 0 0 0 0 0 0 0 7.39609 0 0 A0A8C0Q1N9 A0A8C0Q1N9_CANLF Endothelin-converting enzyme 1 (EC 3.4.24.71) ECE1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] LKAAYRVSLHRPPLPPPP;NLVRKTSSFLD;NTIFYPVEINES;PHFVDQETKPLRSGVACPRQHSR;SLSEGEVYPNGLQV;TENNLGFA 6 9.3 1.0027 -1.5096 0 7.59947 0 0 0 0 0 10.3057 0 7.7341 0 0 9.3906 0 8.8558 A0A8C0Q1P2 A0A8C0Q1P2_CANLF Brain enriched guanylate kinase associated Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFPAGFRHEAFPGYAASL;GRSPEPPAGDRGPGPA;LARLGLRREARLPFS;NSTDSAAEDEEEAEAE;VGNGKLGG 5 9 1.0021 -0.69204 0 9.91025 5.51497 0 0 0 0 0 0 0 0 0 16.3035 0 0 A0A8C0Q1P8 A0A8C0Q1P8_CANLF Zinc finger and BTB domain containing 40 ZBTB40 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" ELPATSCG;KCRMSFPTLQDHRKHIHE;PYDCKKCRMSFPTLQDHR 3 2.2 1.0029 -1.0078 0 0 0 0 0 0 9.28517 0 12.1413 0 0 0 0 0 0 A0A8C0Q1Q9 A0A8C0Q1Q9_CANLF Plakophilin 1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] DPRPGRSAPLALWAWGAADA;GPSVPGPSDPVPSAPF;PVPQQCLT;STEIQKQL;YSKMQAANGSWGYPI 5 6.8 0.98622 -0.42634 0 12.1486 0 9.01845 9.50046 0 0 0 0 0 0 0 0 0 0 A0A8C0Q1R2 A0A8C0Q1R2_CANLF Spliceosome-associated protein CWC27 homolog (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) CWC27 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] catalytic step 2 spliceosome [GO:0071013] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] DSAKDGECEGAEHDEYL;IPREIKKPKKEK;NFSLLSFGE 3 8.7 0.98948 -0.21449 0 0 0 2.79809 0 0 0 0 0 0 0 0 8.08905 0 0 A0A8C0Q1R8 A0A8C0Q1R8_CANLF Growth arrest specific 2 GAS2 Canis lupus familiaris (Dog) (Canis familiaris) actin crosslink formation [GO:0051764] actin filament [GO:0005884]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; cytoskeletal anchor activity [GO:0008093]; microtubule binding [GO:0008017] ERLSQGRYRV 1 3.5 0.9891 -0.26514 0 0 0 0 0 0 10.3652 0 0 0 0 0 0 0 0 A0A8C0Q1U4 A0A8C0Q1U4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AALQRIDRALR;DLAAQRPPRPS;GATDGQCQGATTHC;VLPPGGGA 4 6.3 1.0019 -1.2309 0 0 0 11.1074 10.8602 0 0 0 0 5.80893 0 0 11.676 0 0 A0A8C0Q1U5 A0A8C0Q1U5_CANLF Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) FNBP1L Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; endocytosis [GO:0006897]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] lipid binding [GO:0008289] LVKKYCPKRSSKDEEPRFT;PQQHSHHNEFDDEFEDDD;VIPQIYKQLQEMDERR;VVIPQIYKQLQEMDERRTI 4 10.2 0.99475 -0.083327 0 0 0 0 11.4005 7.58113 0 10.4341 0 0 0 0 0 10.6297 0 A0A8C0Q1U8 A0A8C0Q1U8_CANLF A-kinase anchor protein 7 RI-RII subunit-binding domain-containing protein AKAP7 Canis lupus familiaris (Dog) (Canis familiaris) EPFCSHLELPPPLL;PRAGDSAGAMGQLCCFPF;VLQRYTENRPSWPSGA 3 14.4 0.93778 0.060951 10.0768 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q1X7 A0A8C0Q1X7_CANLF "Fumarate hydratase, mitochondrial (EC 4.2.1.2)" Canis lupus familiaris (Dog) (Canis familiaris) fumarate metabolic process [GO:0006106]; tricarboxylic acid cycle [GO:0006099] fumarate hydratase activity [GO:0004333] GVTERMPVAE;PNDKYYGAQTVRSTMNFKIGGVTER;VAEGKLNDHF 3 7.9 1.003 -1.5179 0 0 0 0 0 7.91672 11.6994 10.0231 0 0 0 0 0 0 0 A0A8C0Q1Y4 A0A8C0Q1Y4_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] PGTPGSHS 1 1.2 1.0044 -1.1044 0 0 0 0 8.50561 0 0 0 0 0 0 0 0 0 0 A0A8C0Q1Z0 A0A8C0Q1Z0_CANLF Septin-type G domain-containing protein SEPTIN9 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent cytokinesis [GO:0061640] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] GVGSPWRGRPP;LVNRVNRKM;PMSQLQSRLEPKPQPTVA;QTLENSEHTPMSQLQSRLEPKPQP;RGAGGGAG;VPAAPTAD 6 7.4 1.0033 -1.5728 7.52896 0 0 0 0 6.35553 7.48897 0 0 9.08966 0 0 9.657 0 0 A0A8C0Q1Z7 A0A8C0Q1Z7_CANLF SCY1 like pseudokinase 3 SCYL3 Canis lupus familiaris (Dog) (Canis familiaris) EAYVEHFTQEQL;GVSDVKNNSGDGE;LDWFADMIPEIKPS;PALCTLLSH;SSKFAAAEITEGESEGWGDEG;VTERVQPL 6 11.8 1.0034 -2.0873 0 0 0 0 0 8.95463 0 7.74248 12.8749 9.12127 4.69265 0 11.2416 0 0 A0A8C0Q222 A0A8C0Q222_CANLF Exocyst complex component 5 (Exocyst complex component Sec10) EXOC5 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893] exocyst [GO:0000145] DAEQYLKNLYDL;FNDHLMPLISSSP;HISYVATKVCHLGD;HSFVQLRADYRSARL;IEQMEMKLDTGIDRTLNCMI;KQFNDHLMPLISSSPKLSECLQKK;VCSGEQLANLDKNIL 7 14.4 0.85823 0.15409 8.46164 8.22463 7.14904 0 0 0 9.84898 0 11.2883 0 0 0 11.9576 9.41979 5.81936 A0A8C0Q230 A0A8C0Q230_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] membrane [GO:0016020] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] AAGGGGGG;AGPAAAGGGGGGPGCRP;CFRISEGAVPE;GGGGGGPG;GPAAAGGGGGGPGCRP;HNKGVYVR;VSIRVTPQSTARTVVLEVLPLLGR;VVAPHVSLFVGG 8 6.6 1.0025 -0.71501 0 0 12.308 0 0 0 0 0 0 6.85137 10.2149 0 9.10504 13.6013 8.19318 A0A8C0Q239 A0A8C0Q239_CANLF NR LBD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] cytoplasm [GO:0005737]; nucleus [GO:0005634] AQDTVTFEVAEAPVP;EALEPWCPA 2 9.3 0.99121 -0.53948 0 0 0 0 0 0 9.63383 0 0 0 0 0 0 0 0 A0A8C0Q253 A0A8C0Q253_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] DLEVYDVP;PAPEHGNEDQEVY;PSAESLSRRP 3 5.5 0.98975 -0.51679 0 6.65793 0 0 0 0 0 0 0 9.06757 0 0 0 0 0 A0A8C0Q264 A0A8C0Q264_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KQISVSWFRD;TVSEEDWNAGET;YVLPPSRE 3 6.6 0.98915 -0.19809 0 0 0 0 0 8.65585 0 0 6.73633 0 0 0 0 0 0 A0A8C0Q266 A0A8C0Q266_CANLF TOPBP1 interacting checkpoint and replication regulator TICRR Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; response to ionizing radiation [GO:0010212] nucleus [GO:0005634] GKRQRDTSNLESSSLQ;KAVSVPKTLE;KDWPRRKRAV;PFFDVMDI;RMVCLTEDSAYLAKFL;TTPDTIKDWPRR;VFPTTAEESPFSRA;VLGGTEFDQLEELRT 9 5.8 0.94393 0.076616 0 0 0 0 10.3676 0 0 0 0 0 0 0 0 0 0 A0A8C0Q277 A0A8C0Q277_CANLF BICD cargo adaptor 2 BICD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeletal anchor activity [GO:0008093]; dynein complex binding [GO:0070840] QLEQARGALSEQREEVSRL 1 2.5 0.95357 0.049511 0 0 5.13746 0 6.42235 5.22095 0 0 0 0 0 0 0 0 0 A0A8C0Q282 A0A8C0Q282_CANLF Oxysterol-binding protein OSBPL8 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] DKENDQEHDESD;DSEIERQHFKDQDMYSDK;ENDQEHDESD;IRRVKISFLLIRTREKAPKPLWL;TDNSEVFWNPTPDIKQ;YYHADFLS 6 8.7 0.97888 0.046253 0 0 9.32429 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q286 A0A8C0Q286_CANLF Clustered mitochondria protein homolog Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005] cytoplasm [GO:0005737] RNA binding [GO:0003723] DTCHRTCFSLH;TVMSHPRYLE;VALSHHLV 3 2.2 0.98933 -0.263 8.36063 8.21233 0 0 0 0 8.63023 0 8.74416 0 6.96532 0 0 8.82037 8.5738 A0A8C0Q2A7 A0A8C0Q2A7_CANLF SET and MYND domain-containing protein 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] QKMKSCLLNSPPIPL 1 1.9 0.95219 0.053904 0 0 0 0 0 0 0 0 0 0 0 0 0 7.13134 0 A0A8C0Q2B0 A0A8C0Q2B0_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDVVK;EVQLVESGGDVVKPG;EVQLVESGGDVVKPGG;GDVVKPGG 7 15.4 0 6.2302 12.8427 12.8158 12.3767 12.7359 13.1184 12.7775 13.2861 13.3859 12.082 13.1399 13.1325 13.5146 12.4323 12.6379 12.4489 A0A8C0Q2B3 A0A8C0Q2B3_CANLF Phosphatase and actin regulator Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] AAIRKELNEFKSTEMEVHEESR;DEEDEDEDGSGE;DGPVLYTDDDDDEEDEDEDG;DGPVLYTDDDDDEEDEDEDGSGE;DSDGPVLYTDDDDDEEDEDE;KPKPKPKPKKTPVPPKGAA;LYTDDDDDEEDEDEDGS;LYTDDDDDEEDEDEDGSGE;PEPREPAAPPA;RKKKTSDKFRET;RTTVLSGTGLSVSREN;VLYTDDDDDEE;YTDDDDDEEDEDEDGS;YTDDDDDEEDEDEDGSGESA 14 12.5 0.43949 0.51478 6.56919 8.10753 0 0 8.69923 4.00135 0 9.26308 6.42213 0 0 4.04658 9.63403 7.33878 11.0285 A0A8C0Q2B4 A0A8C0Q2B4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MYO3A Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cell projection [GO:0042995]; cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein serine/threonine kinase activity [GO:0004674] AALENSASLLCIQADELQ;DLEDFYYKEFL;ENALSTNETVMP;FWMAPEVIA;GVKLVDFGV;KLLDLEDFYYKEFLP;LKKGKRMS;LNLMRKEAIDKLILIQ;LVLELCNGGSVADLVK;NDKDLKAVLEKEACDLAIFSK;NPPHIFAMADLGYQ;VEQLNLMRKEAIDKLILI;YELIEQCFKVIGFTM;YPTRYEESFN 14 11.1 1.0031 -2.4995 0 9.62967 0 9.37297 0 0 9.80311 9.31529 9.37497 9.1104 10.8988 7.70791 10.976 9.78545 8.94696 A0A8C0Q2B9 A0A8C0Q2B9_CANLF Amine oxidase (EC 1.4.3.-) AOC1 Canis lupus familiaris (Dog) (Canis familiaris) amine metabolic process [GO:0009308] copper ion binding [GO:0005507]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038] GESTQEPPLFSSYKPRGEF;HYYDADDPV;IDLDVAGTKNSFQ;IENEGDFLLITPSLE;WYNGKLYQSPEE 5 9.7 0.43506 0.52595 0 0 11.1132 0 11.7068 0 8.82575 13.0194 12.9911 5.41748 0 0 0 10.8254 0 A0A8C0Q2C8 A0A8C0Q2C8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) TMCC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ANKLGNLEEMDAF;GTSGSADS;MDAFLESHKL;MNEKGEITTNT 4 2.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 9.09302 0 0 0 0 0 A0A8C0Q2C9 A0A8C0Q2C9_CANLF Proline rich 15 like Canis lupus familiaris (Dog) (Canis familiaris) PGFWVGAGA 1 3.5 1.0047 -0.80421 0 0 0 0 0 0 9.76626 0 0 0 0 0 0 0 0 A0A8C0Q2E4 A0A8C0Q2E4_CANLF Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVIDVHNRVRMVTVG;MPEFEEED;SAAFAGGE;SPKSAAAAVAGAAKTPG 4 8.8 1.0033 -2.4492 0 0 0 0 7.926 0 7.73376 0 0 0 0 6.10911 0 0 6.58873 A0A8C0Q2G2 A0A8C0Q2G2_CANLF "MLLT6, PHD finger containing" MLLT6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" EQILSLTAKKERLQILNV;GSRLHTFQR;KKLSSGKGVSSFTSA;NMEQLLEKQGDGEAGVNIVEML;PKTPAKSVV;SHTEPDLEDCSFRCRGTSPQ;TSESSRDSKGKKSSSHSL;YHFSKMKTS 8 10 1.0025 -1.1311 0 0 0 0 0 0 9.34112 10.5139 5.25709 0 6.36286 0 6.97453 11.5132 0 A0A8C0Q2G6 A0A8C0Q2G6_CANLF Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) NMT2 Canis lupus familiaris (Dog) (Canis familiaris) glycylpeptide N-tetradecanoyltransferase activity [GO:0004379] FSHLSRNMTLQRTMKLYRLPDATK;VLSSGWNPAPVLE 2 7.3 0.98689 -0.23123 0 0 4.14364 0 0 0 0 0 0 0 0 0 0 0 8.49506 A0A8C0Q2I0 A0A8C0Q2I0_CANLF PTPRF interacting protein alpha 4 PPFIA4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DENFDHNTLA;DEREKLLES;DLRKHRRKLL;DTEIQREIGISNALHR;ELLEKQNFELSQARE;IKSSIGRLFGKKEK;LYGHMLSAF;NIEEHLRQLEGQLE;QLMVNMLDEREKLLESL;SRSGSAADVRFSLGTAPHA;STELRAEEIETR 11 11.5 1.0033 -2.0743 9.93834 0 0 0 11.1831 13.0339 10.1396 0 10.7533 0 0 0 6.93227 0 8.99862 A0A8C0Q2J4 A0A8C0Q2J4_CANLF Podoplanin PDPN Canis lupus familiaris (Dog) (Canis familiaris) VGEDTETTVEKGP 1 8.1 0.94013 0.059587 0 0 0 0 0 0 0 0 6.66846 0 0 0 0 0 0 A0A8C0Q2J5 A0A8C0Q2J5_CANLF CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) Canis lupus familiaris (Dog) (Canis familiaris) cardiolipin biosynthetic process [GO:0032049] membrane [GO:0016020]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] AKFPSDLK;GPVLWRRLLGLLPGRPGLAALLGRL;IDEIVTET;KVLARRKRKRK;VLWRRLLGLLPGRPGLA;VTFSGTEGMFLSLR 6 9.5 1.0031 -2.3652 10.686 0 0 0 0 0 0 0 0 0 7.27761 5.31343 0 9.19729 0 A0A8C0Q2K5 A0A8C0Q2K5_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] DTSKPVQMMRQSNVFN;WLDKDTSKPVQMMRQS 2 5.2 0.98987 -0.20259 0 0 0 0 0 0 0 7.72969 0 0 0 0 8.59708 0 0 A0A8C0Q2L3 A0A8C0Q2L3_CANLF Ammonium transporter Rh type A (Erythrocyte membrane glycoprotein Rh50) (Rhesus blood group family type A glycoprotein) RHAG Canis lupus familiaris (Dog) (Canis familiaris) ammonium homeostasis [GO:0097272] plasma membrane [GO:0005886] ammonium channel activity [GO:0008519] LKKYGFSSVGI;MFWPSFNSAIAETAEEQY 2 8.3 0.94233 0.083804 10.4152 0 0 0 7.33101 0 0 0 0 0 0 0 0 0 0 A0A8C0Q2M9 A0A8C0Q2M9_CANLF L3MBTL histone methyl-lysine binding protein 3 L3MBTL3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] zinc ion binding [GO:0008270] DADCPDIH;DQKEERDIGE;ENCCQYGNVDECLSGGNYCSQ;KAQAAPKSLFENQNIT;LAVRLVPEAALV;NSLPAPARAFKVKPPH;NWDESYDYWCEASSPHIH;QSVYCVLTVAE;VLKQGVPPKGKKAW 9 16.5 1.0023 -1.4464 0 9.62885 8.81263 11.6366 11.5978 11.392 0 9.12057 8.72485 8.65996 9.83736 9.91821 4.43202 7.57418 11.713 A0A8C0Q2N5 A0A8C0Q2N5_CANLF Phosphate transporter SLC20A2 Canis lupus familiaris (Dog) (Canis familiaris) phosphate ion transmembrane transport [GO:0035435]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324] phosphate transmembrane transporter activity [GO:0005315]; symporter activity [GO:0015293] GVLFVLIRIFILK;LIRIFILKK;TPDTDKPCVAVRGHL;VLFVLIRIFILKKE;VLIRIFILKKE;VSDESLNKIQEVE 6 6.6 1.0044 -0.81877 0 8.01201 8.17562 0 6.26531 10.5165 3.67954 0 0 8.97965 0 0 0 0 6.48183 A0A8C0Q2P4 A0A8C0Q2P4_CANLF Alpha kinase 3 ALPK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAPGAPGPSPTLVP;ATKGQSEKGSMASLSPQSRVPE;DQAQKAPAPGPVPGP;EDSDARFTCIVTGYPEPEVT;ELAADEGK;ELAADEGKQDTP;GAGGRAGA;IPYATLEEDLGK;LLLLLKLSSTETG;NWKPRKEVVGDVDTLRK;QEGSVGGP;SNSRGQGVIEP;VGTMTEYKIHQRWF;VTQAERTQTDERMQED 14 10.9 1.0044 -1.1044 0 0 0 7.93334 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q2P6 A0A8C0Q2P6_CANLF Ski oncogene (Proto-oncogene c-Ski) Canis lupus familiaris (Dog) (Canis familiaris) SMAD binding [GO:0046332] AKYSAQIEDLQVKLQH;SQLPPSSEKDK;SREECTCESGSWPAG 3 5.5 0.98801 -0.46539 0 0 0 0 13.2543 9.24313 0 6.93239 0 0 0 0 10.6169 0 0 A0A8C0Q2Q1 A0A8C0Q2Q1_CANLF Ferric chelate reductase 1 FRRS1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EARNAEDLSGPPIG;IFNWTHWSM;RYTNPRNVIS;TTALTCIA 4 6.7 1.0019 -1.2556 9.33166 0 0 10.4505 0 9.46267 0 0 9.07559 0 0 0 0 7.39017 0 A0A8C0Q2Q6 A0A8C0Q2Q6_CANLF Kappa-casein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EPINHQYVPYPFYAKP;EVQNQEQPTCREN;HYVLNSFSHYEPNY;MKRFFLVVN 4 28.6 1.0012 -0.74648 0 0 20.1306 0 18.8376 19.038 0 0 0 0 7.52591 0 0 0 0 A0A8C0Q2Q8 A0A8C0Q2Q8_CANLF EFR3 homolog A Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659] plasma membrane [GO:0005886] DELRATIWEPQHMDKIVPSLLFNM;EALKKAIDTSGMEEQEK;EAPYFLPEHIFRD;EDNVQKNYELL;FVKFANIEEDTPSYHRRYDFFVSRF;GSGERLSVPYV;NTLLKHLRLSVEFEANDLQ;SFVKFANIEE;TIELANEE 9 16.5 1.0033 -0.87335 0 0 8.88615 9.22398 7.77906 0 5.14849 0 9.75139 0 0 0 0 11.7805 7.60259 A0A8C0Q2R1 A0A8C0Q2R1_CANLF DDHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ECVVFSIDGSFAASVSIMGSDPKVR;LVKFVPCPAV;PYSHDDGCLGNSQD;SDSVESSDDEFFDAREEVAE 4 7.1 0.98459 -0.25339 0 0 0 0 0 0 0 9.67885 0 0 0 0 0 0 0 A0A8C0Q2R9 A0A8C0Q2R9_CANLF RAS p21 protein activator 1 RASA1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AADTFGAG;ACSGLPEAGGAALGAGPG;AGGEPALAKGTASLA;EQVLNDTVDGKEIYNT;GWMWVTNLRTDEQGLIVEDLVE;LHVVYALSHVCGQDR 6 9.8 1.0024 -1.841 7.24384 0 0 8.02713 0 0 0 0 0 0 0 0 0 7.95058 0 A0A8C0Q2S3 A0A8C0Q2S3_CANLF Insulin receptor substrate 2 Canis lupus familiaris (Dog) (Canis familiaris) insulin receptor signaling pathway [GO:0008286] insulin receptor binding [GO:0005158] GVCGGPSP;VGAGAGAG;YMRMWCGS 3 1.5 1.0025 -1.3686 0 0 0 0 7.4801 0 0 6.65134 0 0 5.91399 0 0 7.2149 8.71668 A0A8C0Q2V2 A0A8C0Q2V2_CANLF Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated potassium channel activity [GO:0005249] GAVIMFILNFEV;GVGSAGAP;HYSPFKAVWDWL;SLLQHCKP;YTAVFTPYSAAFLLKETEEGPPAP 5 6.1 0.98511 -0.43959 0 7.74651 0 0 8.49386 0 0 10.5919 9.59613 0 0 0 0 0 0 A0A8C0Q2W9 A0A8C0Q2W9_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC22A18 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GVSMGKAG;KAISRLLLQPGVLPV;VLPVFLVKVV 3 6.8 1.0029 -1.662 0 0 0 0 0 5.38805 0 0 8.53803 0 0 0 7.46222 0 0 A0A8C0Q2X0 A0A8C0Q2X0_CANLF AB hydrolase-1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660] endomembrane system [GO:0012505] acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620] FLARRHLRTV;GGGAGGGR 2 4.2 0.99054 -0.2221 0 0 0 0 7.75081 0 0 0 0 0 0 0 0 0 0 A0A8C0Q2X2 A0A8C0Q2X2_CANLF Grh/CP2 DB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] WRWSRPGDRILDIDVP 1 3.4 0.96058 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 9.26927 0 0 A0A8C0Q313 A0A8C0Q313_CANLF Carboxypeptidase Z CPZ Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] FPGGCHGPSAADSATCVDMQLRT;LHGGDLVVSYPFDF;VESSSEYI 3 7.1 0.98768 -0.40223 0 0 7.07842 0 0 0 0 0 0 0 0 8.54589 0 0 0 A0A8C0Q323 A0A8C0Q323_CANLF Synaptotagmin SYT2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488] axon [GO:0030424]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905] GGEGGTPP;GGGGGGGA 2 2.7 0.98902 -0.26417 0 0 0 0 0 0 0 0 0 0 0 9.68788 0 0 0 A0A8C0Q344 A0A8C0Q344_CANLF Lethal giant larvae homologue 2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] DEEAEHAVE;EEQFKVFTLPKV;EQFKVFTLPKVSAKLKLKL;GLEGQGGTEGH;GYRWKGHERL;NQQLENVCWQ;PRCLVESAEA;SASDRGVQPQQWGS;VGSFDPYSDDPRL 9 8.9 1.0024 -1.8571 0 0 0 0 8.47917 12.0669 10.097 4.98445 8.29792 0 0 0 5.61241 6.01705 0 A0A8C0Q365 A0A8C0Q365_CANLF Bcl-2 Bcl-2 homology region 1-3 domain-containing protein BCL2A1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] LTKKLLEQRISSDV 1 5.4 0.93444 0.060769 0 0 0 7.72083 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q371 A0A8C0Q371_CANLF Thrombospondin 2 THBS2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] ANQADHDHDGQGDACDSDDD;DACDSDDDNDG;DGQGDACDSDDDNDG;DGTGDTCDDDDDND;DSDDDNDG;DTCDDDDD;GDTCDDDDD;GQGDACDSDDD;GTGDTCDDDDDNDGVDDE;GVSLKVVNSTTGTGEHLRNALW;HFSDPMYKCEC;IDGRWSPWSPWSACTV;SNANQADHDHDGQGDACDSDDDN;TDNNGEGDACSVDI;TGDTCDDDDDND;VGDQCDNNEDIDEDGHQN 16 10.7 0.99769 -3.3915 7.8783 8.05523 0 0 5.26484 0 6.21556 8.35191 0 0 8.43513 7.00899 0 0 2.13136 A0A8C0Q376 A0A8C0Q376_CANLF Histone-lysine N-methyltransferase (EC 2.1.1.355) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" histone H3K9 methyltransferase activity [GO:0046974]; zinc ion binding [GO:0008270] CDYKVVKDMEYYL;DYESDEFTVD;VENTVDLEGPP 3 8.3 0.98974 -0.5165 0 0 0 0 0 0 0 0 4.81219 0 0 11.382 0 0 0 A0A8C0Q399 A0A8C0Q399_CANLF HERV-H LTR-associating 1 Canis lupus familiaris (Dog) (Canis familiaris) ALVQGPHH;DPDKFPTRYC;LEEGAITAAP 3 5.7 1.0039 -1.0832 0 0 9.6705 0 0 0 7.01078 0 0 0 0 0 0 0 0 A0A8C0Q3A1 A0A8C0Q3A1_CANLF Metal regulatory transcription factor 1 MTF1 Canis lupus familiaris (Dog) (Canis familiaris) cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; DNA-templated transcription [GO:0006351]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone acetyltransferase binding [GO:0035035]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ETGHYLSIS;QEEACQCQCACRDS;QEQIQQASKVEKVFFTT;SEFLSLQSLDTPSNLIP;VQQIGLSVPVI 5 7.8 1.0029 -0.73305 0 0 0 0 0 9.69342 0 0 0 0 0 0 0 8.92867 10.1431 A0A8C0Q3A8 A0A8C0Q3A8_CANLF Potassium channel domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) stabilization of membrane potential [GO:0030322] membrane [GO:0016020] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] GAAGRARAGLRRGPGLWRRRRRRR;RKTSSGRANR;VGAQQRLGQL 3 8.5 0.99625 -0.58424 0 0 0 0 0 0 0 0 0 0 0 0 5.31005 0 0 A0A8C0Q3C5 A0A8C0Q3C5_CANLF Dishevelled segment polarity protein 2 DVL2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; Wnt signaling pathway [GO:0016055] ENLEPETETESVVSLRRERPRRRDS;GVPNLRAHPGLHPYGPPPGMALP;LSGGCESY;LSGGCESYLV;RLLKRHRRRRKQ;STGGWCPG;TGGHRPGG;WLPQPTSPGQSW;YHELSSYTYGGGSASS 9 16.2 0.99995 -2.8224 0 0 11.2085 0 0 4.34951 5.56727 0 14.0042 11.2981 0 10.8817 0 0 0 A0A8C0Q3C7 A0A8C0Q3C7_CANLF Paladin Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] AELHDLKEVVLE;DTVSETMTPMH;EDLLGEPHAVT;ENLQGLGPGIQ;VLAFWHMQGFPEVGEEELVSVPD;VLFHHSGAAS;YFLVRDIAE 7 10.8 1.0043 -1.0905 0 0 0 0 0 0 8.63434 10.1102 9.80211 10.465 6.54221 7.22959 13.7607 0 0 A0A8C0Q3D3 A0A8C0Q3D3_CANLF Tissue factor (Coagulation factor III) F3 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] membrane [GO:0016020] HVYTVQISPRLGN;SWSSSSPSSCLCLCTSAGSCEQ 2 14.8 0.99173 -0.27062 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9877 0 A0A8C0Q3F1 A0A8C0Q3F1_CANLF Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) Canis lupus familiaris (Dog) (Canis familiaris) glycine catabolic process [GO:0006546] glycine cleavage complex [GO:0005960]; mitochondrion [GO:0005739] aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483] AAAAVHLAAALL;NMEGTVIGTVT;VLSNAGCWDKDLALIQGKV;YVLSNAGCWDKDLALIQ 4 12.4 0.47853 0.48736 0 0 0 0 0 13.0537 0 13.9017 14.0965 0 8.91031 0 13.5894 0 0 A0A8C0Q3F8 A0A8C0Q3F8_CANLF Rho GTPase-activating protein 29 (Rho-type GTPase-activating protein 29) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] GNVNSDKFCRNL;KKWPSTCIEINRI;LIKSKDLLRQLPVSNFNSLHYL;LKGVLRPRAIKV;LKLYLRQLPEPFILF;SISSNSIFDPD 6 6.7 0.9548 0.05044 0 0 0 0 0 0 0 0 0 0 3.76691 0 0 0 0 A0A8C0Q3H7 A0A8C0Q3H7_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2B2 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] NTLHRWSWRTQEPPHHRVQGWIRFL;SLLVDNVKERATWFRTPH;VLDQYNYCSCLP;VYTTVVEQLMLQKQRRFI 4 7.3 0.97437 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0238 A0A8C0Q3H9 A0A8C0Q3H9_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] DGIPYRSVPEW;EPPADMGGRQDVR;FGDKPYGEMSNQEV;GAGPLGCK;LLLLRAPLPP;PGPGGLVE;PSQDCKTVAIKTLKDTS;SLRWEPPADMGGRQDVRYSVGC 8 9.2 1.0028 -2.1707 13.4891 8.93375 10.3215 0 0 10.2847 8.49518 8.56251 8.09027 9.86717 8.80129 8.98194 8.1152 9.95858 9.99067 A0A8C0Q3I8 A0A8C0Q3I8_CANLF Tudor domain-containing protein TDRD15 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] ASHANEKIVSEEQ;ESVSGEWQRGRVMEKK;GTQVLCPVSESKISNMFKET;GVSTGSTTIQPQ;IESIKISSALSPS;IVYAHLDWFNKDEHLYYV;IYALALIYPNCLYNLV;VISASKIYEFQREFLTV;VTYSENKIDQLM;YHILQREMQHIP;YSENKIDQLMNP 11 7.2 1.0021 -1.2038 0 0 0 10.465 0 13.9408 0 8.85966 11.0281 13.2673 0 0 8.89367 0 0 A0A8C0Q3J5 A0A8C0Q3J5_CANLF BTB domain containing 1 BTBD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AASKTVFFFFS;DGTANTFRVMFKEPI 2 5.4 0.98838 -0.49061 0 0 0 0 0 0 0 12.3174 0 0 0 0 0 0 0 A0A8C0Q3K2 A0A8C0Q3K2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;KTIIVIHHISKRKTKNHMI;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 8.2 0.95375 0.04941 0 0 0 0 0 0 0 0 0 7.01089 0 0 0 0 0 A0A8C0Q3L4 A0A8C0Q3L4_CANLF USP domain-containing protein USP36 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] CAKLDRQTQATT;EFDRGKEKKVKKFKRERKRTYN;KVKKFKRERKRTY;NIVRALELFV;QENGQQVGSVTD;QEVEENEHPDTCP;VLNQQAYLLF;VMYGLYAV;WHRTFSPLDIVE 9 9.1 1.0015 -1.3128 0 0 6.82617 0 9.09024 4.4262 0 0 0 3.12102 12.5429 0 0 9.39236 13.1614 A0A8C0Q3N8 A0A8C0Q3N8_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] FQQDLVELSLDWKAEVPDLVL;ILHGNMEVNVPSLA;REKRKSGL;TQAKFDSEMP;WDEASFRTEVSY 5 4.7 1.0022 -1.2763 0 0 6.80038 0 8.74419 8.10255 0 0 0 0 0 0 0 12.7791 11.7112 A0A8C0Q3P4 A0A8C0Q3P4_CANLF GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] mannose-ethanolamine phosphotransferase activity [GO:0051377] IPFVLVMCAFEAVQ;KDRFINEELLLHLFQM;MFVWIQMEQETL;PLLSPTSLFERL;VTKLDTWVFDNMKEF 5 8.7 0.99402 -0.078011 0 9.54299 10.5725 10.5531 0 0 0 8.64566 16.6978 10.2299 0 0 0 0 9.60437 A0A8C0Q3P6 A0A8C0Q3P6_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] FLEDVTKLYH;QCLQHFLDTFNLS 2 5.9 0.94449 0.059655 0 0 0 4.91203 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q3P9 A0A8C0Q3P9_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" EDEM3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380] endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" EQITSSSQ;ESFRSGAK;WMDALLAFFPGLQVL 3 3.3 1.003 -2.1549 0 0 0 0 0 0 0 0 7.44253 0 0 0 9.56434 0 0 A0A8C0Q3Q1 A0A8C0Q3Q1_CANLF LIM zinc-binding domain-containing protein FHL3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DCYCSAFSSQCSAC;TLTQGGVTYRDQP 2 9.6 0.98513 -0.25868 0 0 0 0 0 0 0 0 6.57193 0 0 0 0 0 0 A0A8C0Q3Q8 A0A8C0Q3Q8_CANLF Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) SEC11A Canis lupus familiaris (Dog) (Canis familiaris) signal peptide processing [GO:0006465] signal peptidase complex [GO:0005787] serine-type endopeptidase activity [GO:0004252] IPIVHRVLKIHEKQNG;LFLRCRTFRSLFG;LYKQGQHWLEKKDVVGRA 3 25.7 0.85294 0.15872 0 0 0 0 0 0 0 0 4.48246 4.51046 0 0 7.67349 0 0 A0A8C0Q3Q9 A0A8C0Q3Q9_CANLF Discs large MAGUK scaffold protein 4 DLG4 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] neuromuscular junction [GO:0031594]; neuron projection [GO:0043005] kinase binding [GO:0019900] ASQVAPTTHTLATTHP;EITLERVSRLP;IGFIPSKRRV;IVEGDSFEEIYHKVKRV;VTHSAAVEALKEAGS 5 9 0.99385 -0.12195 5.96451 0 0 0 6.74281 0 0 8.11941 0 3.61436 0 0 0 0 0 A0A8C0Q3S3 A0A8C0Q3S3_CANLF BHLH domain-containing protein FERD3L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] GEEGEGEEGEEEEEEEEEEEER;LDFVADLSLDSPG;MAAYPEGCVDATVL 3 28.6 0.98994 -0.21256 0 0 0 0 0 0 0 0 0 6.01156 14.4174 0 14.9445 0 0 A0A8C0Q3U2 A0A8C0Q3U2_CANLF Phosphoglycerate kinase (EC 2.7.2.3) PGK2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] GAKIVKDIMAKAKSN;GVPMPDKYSLEPV;LMSHLGRPDGVPMPDK;LSKDVLFLNDCVGPEVE;VGPEVEKACANPATGSV 5 15.6 0.99707 -0.59447 0 0 0 10.143 0 0 13.2125 10.2257 0 0 0 0 0 0 0 A0A8C0Q3U3 A0A8C0Q3U3_CANLF Zinc finger protein 615 ZNF350 ZNF615 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FIEKRRLVAH;KGFTLKSPLIRH;KNDLITHQR;LSKLERGGELSMIEDEIHSRICPEI 4 7.7 1.0022 -0.68563 9.5254 0 0 7.69565 0 8.02276 0 0 10.62 9.89175 0 0 0 10.4251 0 A0A8C0Q3V7 A0A8C0Q3V7_CANLF Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein URB2 Canis lupus familiaris (Dog) (Canis familiaris) EDFRMVMQ;GPAGSALPEGGVQVL;LDLQVPELELW;LVVEQLLN;PELLSSYKEELLDQQ;SLGRYCLEQLYLQ;SVALLYKL;TLQLDSLLTPYHVHYFLLLL;VVGPPGSP 9 6.9 0.99726 -3.4378 12.6889 0 0 9.27547 9.13036 8.34447 0 0 11.1577 0 8.31836 8.34092 0 0 11.996 A0A8C0Q3Y0 A0A8C0Q3Y0_CANLF ADP ribosylation factor like GTPase 8A Canis lupus familiaris (Dog) (Canis familiaris) anterograde axonal transport [GO:0008089]; protein transport [GO:0015031] axon cytoplasm [GO:1904115]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DIGGQPRFRSMW;GARTREQKASIS;PRPGRAGRRRRRRRRAAAAAA;SGKTTFVNVIASGQFNEDMIPTV 4 16.2 0.97402 0.047166 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.55278 A0A8C0Q407 A0A8C0Q407_CANLF Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) PPM1A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine/threonine phosphatase activity [GO:0004722] IKKEQKKGRKVIRRKERR 1 4 0.9796 0.048313 0 0 0 0 0 0 0 0 7.53838 0 0 0 0 0 0 A0A8C0Q409 A0A8C0Q409_CANLF Serpin family A member 1 SERPINA11 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] DAVQETDAHHDP;EAIPMSMPPSVDFNKPFL;EGLQGDAVQ;EGLQGDAVQE;EGLQGDAVQET;EGLQGDAVQETD;EGLQGDAVQETDA;EGLQGDAVQETDAHHDP;EKPFEVEHTTEEDF;FMGKVVNPTQK;GDAVQETDAHHDP;GKVVNPTQK;GLQGDAVQETDAHHDP;IIIVDRDTKSPLF;IIIVDRDTKSPLFMGKVVNPTQK;LEAIPMSMPPSVDFNKPFL;LQGDAVQETD;LQGDAVQETDAHHDP;MGKVVNPTQK;PLFMGKVVNPTQK;PPSVDFNKPFL;QGDAVQETDAHHDP;RDTKSPLFMGKVVNPTQK;SPLFMGKVVNPTQK;TIDEKGTEAAGATFL;TKSPLFMGKVVNPTQK;VQETDAHHDP 27 20.8 0 3.1851 8.65324 9.48788 0 9.97528 7.82953 11.1324 10.1585 10.2624 0 9.65361 0 10.6784 8.82674 0 12.1078 A0A8C0Q413 A0A8C0Q413_CANLF Prohibitin Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] DYDERVLPSI;EPCLACLSSGPHSPD 2 7.4 0.94983 0.053889 0 0 0 0 0 0 0 0 0 0 0 3.54139 0 0 0 A0A8C0Q419 A0A8C0Q419_CANLF Olfactory receptor family 2 subfamily D member 2 OR2D2C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVVILLIPV;LVSVFYAMMTPML 2 7.1 1.0041 -1.0893 0 0 0 0 0 0 5.217 0 0 0 0 0 0 0 0 A0A8C0Q422 A0A8C0Q422_CANLF PWWP domain-containing protein PWWP2A Canis lupus familiaris (Dog) (Canis familiaris) ATEASVPDGEADGQQPS;AVSQLIPGAEVRV;FTALHSVSCN;GPADLPPAPA;LMDLSKRYE;PARAAEPAAAAPPGPADLPPAPAA;SECSSSESFDFPPGS 7 11.2 1.0024 -1.7877 0 0 0 9.42431 11.5905 9.48742 9.74441 0 0 0 11.2617 0 0 12.6511 0 A0A8C0Q455 A0A8C0Q455_CANLF Rap-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] EGEAMEECDSGSQP;KFGVIYQKARQT;MLEKMQDDYIPYPS;MQDDYIPYPSIDE;SQMIVSYDEHDVNNTFKFG;VESVYTVFR 6 9.5 0.9865 -0.41162 0 0 0 0 0 0 9.04941 0 0 0 0 9.60227 7.35729 5.46231 0 A0A8C0Q460 A0A8C0Q460_CANLF Immunoglobulin V-set domain-containing protein LOC106559220 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AYCEYSPGWESY;HTITMTLENLWYD;RLLRILLLLVIQGHF;VAQNPPAWILLVPLFLGTLQW 4 31.4 0.80711 0.21484 0 7.53411 0 0 6.86158 0 0 0 0 0 3.64339 0 0 0 0 A0A8C0Q468 A0A8C0Q468_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764]; membrane [GO:0016020] metal ion binding [GO:0046872]; transferase activity [GO:0016740] EDGGGGGG;VGAAARFPAQVPGA 2 9.2 0.93682 0.060914 0 0 0 0 0 0 0 0 0 6.67666 0 0 0 0 0 A0A8C0Q480 A0A8C0Q480_CANLF Cyclic AMP-responsive element-binding protein 3-like protein 4 Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] APGTPEQGLPGNGLQ;RVLKKIRRK;SEPEDFLKLFI;VFLTEEEKRLLGQEGVSL 4 13.9 1.0025 -0.66651 0 0 0 0 0 0 0 9.53111 0 4.49838 2.78676 0 0 9.65802 0 A0A8C0Q488 A0A8C0Q488_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FSFCACKLLSIVTRGCETVEMTLRR;GKDFMDTAGERSPS 2 5 0.9908 -0.29762 0 0 0 0 0 0 0 0 0 0 0 0 0 8.20789 0 A0A8C0Q490 A0A8C0Q490_CANLF Apolipoprotein L5 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289] HYILFDAKAWEML 1 3.5 0.94036 0.059754 9.03908 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q492 A0A8C0Q492_CANLF SAP domain-containing protein CCAR1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737] DPMEAEEAEDEED;ERQRPRQREKQTLCREPNVG;LVEATYNPNMPFKWNAQRIQTLPN;TFGVQAQPQPQ;TIYTQQTALAAAGL;VSYPTPRS;YSQPQQALYSVQQQLQ 7 8.9 1.0016 -0.70936 0 0 9.88724 12.2797 0 7.91259 13.0532 9.80571 0 10.2026 8.84345 0 0 0 13.9463 A0A8C0Q4A1 A0A8C0Q4A1_CANLF "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase)" CARS1 Canis lupus familiaris (Dog) (Canis familiaris) cysteinyl-tRNA aminoacylation [GO:0006423] ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872] PAGSPPCKLRLYNSL;TDPDKKHMLERIQH 2 4 0.99417 -0.55828 0 0 0 0 0 0 0 0 0 0 0 0 0 7.71019 0 A0A8C0Q4C0 A0A8C0Q4C0_CANLF Zinc finger and BTB domain containing 16 ZBTB16 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEEEEDRRARYLKNIF;AEKEERLRRTVRRVL;RFLDSLRLRM;VRRVLKCDVGKERPLEPAVL;YSVLPNHK 5 9.3 1.0022 -1.267 0 0 0 8.48317 7.72561 0 9.49913 0 0 0 0 3.35572 7.68011 6.97223 0 A0A8C0Q4D3 A0A8C0Q4D3_CANLF Thioredoxin domain-containing protein TXNDC11 Canis lupus familiaris (Dog) (Canis familiaris) GSSSSSSDDAEDEGGGGGG;GSVPHIEENRY;LDFLSNYEPGVLGYF 3 5 0.99774 -0.088893 0 0 8.2555 0 0 0 0 0 6.82604 0 7.25058 0 0 0 0 A0A8C0Q4D7 A0A8C0Q4D7_CANLF Heme oxygenase 1 (EC 1.14.14.18) Canis lupus familiaris (Dog) (Canis familiaris) heme oxidation [GO:0006788] endoplasmic reticulum membrane [GO:0005789] heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872] ALEEEIEHNREN;APQPQPAAPSAGRMERPQ;EELQELLSKDTE;GVDFFTFP 4 13.4 1.0031 -1.532 0 0 7.26707 9.80366 0 0 0 0 9.10939 0 0 9.78534 0 0 10.5198 A0A8C0Q4E2 A0A8C0Q4E2_CANLF Homeobox protein goosecoid GSC Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AARGDRAFGDSRSGPGS;HSWWAGQQLVK;PPRRPRSRRGA;TTTSTGSCTCR 4 8 0.98774 -0.47046 0 9.39735 0 0 0 0 0 0 3.97682 0 0 6.14066 7.84768 0 0 A0A8C0Q4F2 A0A8C0Q4F2_CANLF Olfactory receptor family 2 subfamily M member 9 OR2M9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IMIVFPVVII;LIYLDTQLHIPMYFF 2 8 0.9893 -0.52541 0 0 0 0 0 0 0 8.56316 8.54578 0 0 0 0 0 8.88643 A0A8C0Q4F7 A0A8C0Q4F7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;QSEKDKHYMFSYI 5 4.4 0.9401 0.059587 0 0 0 0 0 0 0 0 0 0 8.72219 0 0 0 0 A0A8C0Q4G8 A0A8C0Q4G8_CANLF GCS light chain (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) GCLM Canis lupus familiaris (Dog) (Canis familiaris) glutathione biosynthetic process [GO:0006750] glutamate-cysteine ligase complex [GO:0017109] enzyme regulator activity [GO:0030234]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226] IPDIQAQEWV;SEELRDCIQK 2 7.9 1.0023 -1.2229 0 0 8.41583 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q4J4 A0A8C0Q4J4_CANLF Enamelin ENAM Canis lupus familiaris (Dog) (Canis familiaris) DETFPGQNRWGMEEPS;EEMFEQDFEKPKEKDPPKAE;ETNSTQSNPG;GGRPPYYSEEMFEQDFEKPKE;GNSGPGPNTVSNPTAQ;GTFMGHRQNGPFYRN;PSYNTAPTVPPP;QYQMPMWPQPPP;SGPGPNTVSN 9 9.5 1.0013 -0.94637 0 7.3594 0 0 0 0 9.65655 0 8.79805 0 8.55209 0 0 10.7089 4.74626 A0A8C0Q4K2 A0A8C0Q4K2_CANLF Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein RPP38 Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] fibrillar center [GO:0001650]; nucleolar ribonuclease P complex [GO:0005655]; ribonuclease MRP complex [GO:0000172] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] GVNEVTRALERNGLLLVLVCKS;KIEDKKRKKKQFLKK;LQKIEDKKRKKKQFLKKQSP;PLKIKKVIPNPSKIRKPPKSKK;VLQPLKIKKVIP 5 23.8 0.73699 0.24614 7.45771 0 0 4.61559 10.5553 0 0 0 0 0 0 0 0 5.85619 0 A0A8C0Q4K6 A0A8C0Q4K6_CANLF Growth factor independent 1 transcriptional repressor EVI5 GFI1 Canis lupus familiaris (Dog) (Canis familiaris) CMYQFECMIQEH;ESQCALKEMQDKVLDIEKRNNSFPD;TENRLLKQ 3 5.9 0.9402 0.085978 0 0 0 0 0 0 0 9.30424 7.26313 0 0 0 0 0 0 A0A8C0Q4M5 A0A8C0Q4M5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MAFLYTNNETEETE;PKDTDPVKHRD 2 3.3 0.98515 -0.24037 0 0 7.90352 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q4N4 A0A8C0Q4N4_CANLF HAUS augmin like complex subunit 1 HAUS1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; spindle assembly [GO:0051225] cytoplasm [GO:0005737]; HAUS complex [GO:0070652]; microtubule [GO:0005874]; spindle [GO:0005819] KSKNEEIKLELEKL 1 5.1 0.983 -0.25204 0 0 0 0 0 0 0 0 8.84562 0 0 0 0 0 0 A0A8C0Q4P0 A0A8C0Q4P0_CANLF Actinin alpha 2 ACTN2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] DQMNQLKQYEHNIINYK;YGKEQILLQKDYE 2 3.4 0.98966 -0.2005 0 0 0 0 0 0 0 0 0 0 0 0 10.9763 0 8.22752 A0A8C0Q4Q1 A0A8C0Q4Q1_CANLF YY1 transcription factor YY1 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; B cell differentiation [GO:0030183]; camera-type eye morphogenesis [GO:0048593]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of miRNA transcription [GO:1902894]; positive regulation of DNA repair [GO:0045739]; positive regulation of gene expression [GO:0010628]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]; telomere maintenance [GO:0000723] chromatin silencing complex [GO:0005677]; Ino80 complex [GO:0031011]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; four-way junction DNA binding [GO:0000400]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]" DDEDGGGGDHGGGG;EEEDDDDE;EEEEEDDDD;LRTHVRIHTGDRPYVCPFD;TLEGEFSVTMWSSD;TTVVGEEEEEDDDDED;TVVGEEEEEDDDD 7 14.4 0.9876 -0.46464 0 0 0 0 7.15684 0 0 0 0 6.52615 3.50513 0 0 0 0 A0A8C0Q4R3 A0A8C0Q4R3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GAPSPWSLPTT;VAMRTLILHTK 2 20.8 0.99319 -0.55608 0 0 0 0 0 0 0 0 0 0 0 8.43162 0 0 0 A0A8C0Q4R8 A0A8C0Q4R8_CANLF POM121 transmembrane nucleoporin like 12 Canis lupus familiaris (Dog) (Canis familiaris) AALQRIDRALR;VGPWQQGSAACSPRPAPPD;VLPPGGGA 3 6.6 0.95206 0.04981 0 0 0 0 0 0 0 0 0 0 7.57365 0 0 0 7.27118 A0A8C0Q4S1 A0A8C0Q4S1_CANLF Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAREDLFCYWEK;DIKSECLLPYYTAHSYRSMGVFNT;ETRKGKKE;EVIDVHNRVRMVTVG;LTTGAASISPGSSM;MLLARPTKSGRGRKPTKILELTR;MSSVGAST;RKPTKILELTRLLPLKFV;TGAASISPGS 9 19.9 1.0023 -1.8719 0 0 0 14.6874 8.82861 0 9.36741 9.35101 11.6555 0 11.0364 0 3.46728 0 0 A0A8C0Q4T1 A0A8C0Q4T1_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAGGGGGG;GGGGGGGA;GGGGGGGD;GGGGGGGG;PSALYCMLP;TLGPSALYCMLP 6 10.7 1.0029 -0.9785 0 0 10.5421 0 0 0 0 0 0 0 0 0 0 6.40873 0 A0A8C0Q4T3 A0A8C0Q4T3_CANLF FERM domain-containing protein EPB41L2 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] actin binding [GO:0003779]; structural molecule activity [GO:0005198] DEVQEDVSEEAAKRES;TETKTITYE;VVEREAPAP 3 2.9 0.9879 -0.26078 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.48997 A0A8C0Q4U2 A0A8C0Q4U2_CANLF C2H2-type domain-containing protein ZNF827 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] metal ion binding [GO:0046872] NAADRPANHTKL;QDISVKMASDFLMKLSAE;SWKFNDQLFP 3 4.4 0.97079 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.58606 0 0 A0A8C0Q4W8 A0A8C0Q4W8_CANLF Centrosomal protein 68 Canis lupus familiaris (Dog) (Canis familiaris) KKDLDEHQSL;SVSPASTLKSPTNGS 2 3.6 0.98945 -0.21657 0 0 0 0 0 0 0 0 0 0 0 0 10.5298 0 0 A0A8C0Q4Y7 A0A8C0Q4Y7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IGQWNRIENPEVDPEL;QKRPRIARGILKKKTVAGGITM;YWHKNRHIGQ 3 6.6 0.99262 -0.1692 7.66242 8.64832 0 0 0 0 9.86309 9.38198 0 0 4.70587 9.38558 0 0 0 A0A8C0Q4Y8 A0A8C0Q4Y8_CANLF RUN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AAAGAAGREGEAGPP;AAGREGEAGPPLAS;GGGGGGGA;GGGGGGGG;GTRGGRGGGREARAARGL;LRALKHELAFKLQSSDLGV;PGGGGGGG 7 6.6 0.98646 -0.32243 7.34625 15.7059 0 0 0 0 0 0 0 8.81753 0 0 0 0 0 A0A8C0Q4Z2 A0A8C0Q4Z2_CANLF Aftiphilin clathrin-binding box domain-containing protein AFTPH Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] trans-Golgi network membrane [GO:0032588] clathrin binding [GO:0030276] DSCSWAAFGD;ESGELLDVWTEL;ESHHRKEAWQSHRT;FSEVSPSGVGFVDF;IRMYSSSPPPLDNGAEDDD;KCADLCMDSIKTSD;KVLMFPATLTP;LDNGAEDDDDD;NRLERIFEACFPSI;QDDCSAFQDSDDFADFSSAGPS;VGTPESFSPGDFRT 11 16.9 1.0024 -1.3598 7.10999 0 9.51446 0 0 9.83813 7.95797 7.81449 0 0 0 9.05972 7.72363 0 0 A0A8C0Q4Z5 A0A8C0Q4Z5_CANLF Structural maintenance of chromosomes protein 5 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DTYDAVLWL;EEIERQRHTLEARIKEKA;EKQLETSCKEKTEYLEKMIQRNER;FRVVDEINQGMDPIN;GAEQTVPQEYQTA;GERSVSTMLYLMALQ;IEDLQNELKTTE;RRHLEEQLKE 8 10.7 1.0027 -1.3531 0 5.60703 9.12908 0 0 4.863 11.2325 0 4.2156 9.54649 8.34944 0 9.25051 9.15353 0 A0A8C0Q520 A0A8C0Q520_CANLF Zinc finger and SCAN domain containing 20 LOC100856607 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ARLRERGFLRTLEQCRYRFKNLQTH;EPYIHEKLRTCHRN;NSHLVCHQRIHIREK;NWAGECGVEKQWETPSED;TGEKPYKCGECWKSFN;VTWDGSELAEEPQEEP 6 11 0.99207 -0.28894 0 0 0 8.75379 0 0 0 0 9.9976 0 0 0 0 9.58864 0 A0A8C0Q530 A0A8C0Q530_CANLF Endothelin-converting enzyme 1 (EC 3.4.24.71) ECE1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] NLVRKTSSFLD;NTIFYPVEINES;PHFVDQETKPLRSGVACPRQHSR;SLSEGEVYPNGLQV;TENNLGFA;VSNSKEFSEHFHC 6 9.6 0.93939 0.059608 4.75339 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q539 A0A8C0Q539_CANLF Ankyrin 3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] AEPTEVIIRET;AIDMSKRDFVEERL;AQNGNNDQSIT;CVRDKQKVLGEQQKTKE;ETMTTTTIIEKHKMNV;GEGGVNGY;GVLQGHCVRDK;KHHYLPEREVDMIE;KSPLTPETPSSE;LQQGASPN;LVSFMVDARGGSMRGSRH;PGADVSDS;QYFAVVSRIKQESN;RRQSFASLALRKRYS;SDDEVRKANAPEMLSDG;SELSDEEDST;TDQKSGAQFFTLE;VLSPAKSAVDVISS;YLPEREVDMIEVSLQ 19 5.3 0.99718 -3.8026 9.5225 11.406 16.2188 9.54751 8.79344 0 8.0343 16.6582 16.7175 0 7.5089 8.78957 3.76458 12.3456 16.506 A0A8C0Q541 A0A8C0Q541_CANLF PNN interacting serine and arginine rich protein PNISR Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607]; presynaptic active zone [GO:0048786] RNA binding [GO:0003723] KERSRSIDKDRKKKDKEREREQD;QEEQSEPEMTEEEKEYQMML;RVKIRDRRRSNRNSIERE;SPIALPVKQEPPQ;TKAPAKQL;WDQGGQPWQQWPL 6 12 1.0023 -1.445 0 0 4.40939 0 0 0 0 0 12.7332 0 0 0 8.77956 6.26843 5.81229 A0A8C0Q542 A0A8C0Q542_CANLF Cyclin D3 CCND3 Canis lupus familiaris (Dog) (Canis familiaris) LAMNYLDRYLS;LCIYTDHSVSPRQLRDW;MKSAGGGG 3 14.9 1.0033 -1.1044 0 0 0 0 0 0 10.0656 0 10.4332 0 0 0 0 0 0 A0A8C0Q543 A0A8C0Q543_CANLF Nucleoporin 214 Canis lupus familiaris (Dog) (Canis familiaris) FGGTSATT;GSVSSKSSVSPSAS;IVSKDFFSPKKISGRVGEDVC;LEWDRHLEQKRKQKRLLVPERETL;QLRLYNQTSQ;SAPTLPVASG;SLPQAPLQ;SLPSDVTSQ;STLKTTLLEG;VEEAREQNERDCDS;VGTSEEMKMLRTESDDLHTFLLE;YYLSYIEEWDLVL 12 7.8 0.99597 -0.11395 0 0 0 0 12.1665 0 0 0 0 0 0 0 0 0 0 A0A8C0Q552 A0A8C0Q552_CANLF "gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" BBOX1 Canis lupus familiaris (Dog) (Canis familiaris) carnitine biosynthetic process [GO:0045329] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] FEDVLKNDEHAY;GKVEGGHGKGRE;VLKLGKRIGFLY 3 5.7 0.84402 0.19356 0 0 0 0 0 10.9014 0 0 0 0 0 0 0 0 0 A0A8C0Q554 A0A8C0Q554_CANLF LON peptidase N-terminal domain and ring finger 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] DVTLKIYRAE;GALEAYAA;GGGGGGGD;GGGGGGGG;PDVARSSPGGSR;SASELSPEQNEEVPEVT;VGGGGGGG;VGGGGGGGG 8 8.1 1.0022 -0.67869 11.9663 0 0 0 0 0 0 0 0 8.42585 3.10688 0 0 0 0 A0A8C0Q556 A0A8C0Q556_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] APGMRFPLLEAVDP;IVLLALRLRRWHVSRLL;LLSQESCEKKD;SLLDDSKFPIEDT;YSVPEELE 5 6.7 1.0027 -0.8616 0 0 8.85779 0 0 6.89809 6.40018 0 0 9.62653 3.1981 0 0 0 0 A0A8C0Q559 A0A8C0Q559_CANLF One cut domain family member ONECUT3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GADFRGELA;GGGGGGGA;GGGGGGGG;PGGGGGGG 4 5.7 0.99214 -0.036635 7.69014 0 0 0 0 0 0 0 0 9.30392 0 0 9.02106 9.68682 0 A0A8C0Q571 A0A8C0Q571_CANLF Ankyrin 3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] ETMTTTTIIEKHKMNV;EVLDMSDDEGEDAMT;GEGGVNGY;LQQGASPN;LVSFMVDARGGSMRGSRH;QYFAVVSRIKQESN;RRQSFASLALRKRYS;SLEDSKLEDSMPL;VLSPAKSAVDVISS;VTAEDTSLEDSK 10 4.7 0.86415 0.17461 0 0 3.4351 0 0 8.49586 0 0 0 0 9.57758 0 0 0 0 A0A8C0Q577 A0A8C0Q577_CANLF Gastric inhibitory polypeptide (Glucose-dependent insulinotropic polypeptide) Canis lupus familiaris (Dog) (Canis familiaris) regulation of fatty acid biosynthetic process [GO:0042304]; regulation of insulin secretion [GO:0050796]; response to glucose [GO:0009749] extracellular region [GO:0005576] hormone activity [GO:0005179] EESREQQGSLP;SLCVFHTKV 2 13 0.9914 -0.27293 0 0 0 0 0 0 0 0 7.50383 0 0 0 0 0 0 A0A8C0Q598 A0A8C0Q598_CANLF Eukaryotic translation initiation factor 4E binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of translational initiation [GO:0045947] cytoplasm [GO:0005737] eukaryotic initiation factor 4E binding [GO:0008190] CCCCWGCW;CCWGCWRRPEDR;ILKKKKKAYWVLH;KLILKKKKKAYWVL;PLAGAAGA;QKKKKKKK 6 12.3 0.99195 -0.20866 0 0 0 0 0 0 0 6.27704 0 0 0 6.60352 0 0 0 A0A8C0Q5A2 A0A8C0Q5A2_CANLF MAM domain-containing protein MAMDC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSAMEASCNFEE;RRGEQSISW;YSCERQHQVIF 3 5 0.99056 -0.21113 0 0 0 0 0 0 0 0 0 4.61424 0 0 0 2.11187 0 A0A8C0Q5A3 A0A8C0Q5A3_CANLF Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA binding [GO:0003723] LSLKNIVVRGLKKHRLNLLVL;NIHISWID 2 4 0.98741 -0.46288 0 0 5.15178 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q5A5 A0A8C0Q5A5_CANLF SH2 domain-containing protein PIK3R1 Canis lupus familiaris (Dog) (Canis familiaris) AFNETIKIFEEQCQSQ;EDNIEAVGKKLHEYNTQFQEKSR;GVGLSLPS;VVDGEVKHCVI 4 8.9 1.0044 -1.1044 0 0 0 0 0 0 0 0 11.753 0 0 11.2579 0 11.5181 0 A0A8C0Q5C2 A0A8C0Q5C2_CANLF F-BAR domain-containing protein PSTPIP2 Canis lupus familiaris (Dog) (Canis familiaris) EDWQSEHIKACEIFEA;NFYCPQKNTAPQ;TGALFRANFWSSDILSTAGYDCI;VTSDDMYEEVRKSLEAC 4 21.7 0.9913 0.0074341 4.74792 0 10.4747 8.01151 0 8.64479 0 0 9.90608 11.4244 10.3638 0 0 0 0 A0A8C0Q5C5 A0A8C0Q5C5_CANLF Apolipoprotein L3 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576] lipid binding [GO:0008289] KVELEKRIRKLRRL;LGVAATVTHMSTSL;LQLSPCCQP 3 9.3 1.0041 -0.80421 0 0 0 0 0 0 0 8.42803 0 0 0 0 0 0 0 A0A8C0Q5D9 A0A8C0Q5D9_CANLF L-serine ammonia-lyase SRR Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] catalytic activity [GO:0003824]; GTPase activator activity [GO:0005096] DIIKFFNERAEHHDAQEILQ;EPPPPPGTED;KMAALFTKVGK;LVEAYREIIRDNNMDF;LVVPFSQIVCIH;MFLPRGTSWSPMKKNE;YVWEHLDIG 7 7.7 1.0033 -0.89151 0 0 0 5.38795 12.9018 0 0 0 10.6119 0 0 6.87258 0 6.14651 0 A0A8C0Q5F0 A0A8C0Q5F0_CANLF Ssu-2 homolog SSUH2 Canis lupus familiaris (Dog) (Canis familiaris) heat shock protein binding [GO:0031072]; unfolded protein binding [GO:0051082] EAPGRPLDQRCWSSFMDLRVPTVTE;ENTMVYPIV;LSFEADSPPAPPAELLDRLPSYDW;YQGQTYVYYIYGTDHRVYVVDYPE 4 21.9 0.99255 -0.042885 12.1566 0 8.79688 6.21138 0 6.74039 0 0 0 0 0 0 6.58963 0 0 A0A8C0Q5H5 A0A8C0Q5H5_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) TEK Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; circulatory system development [GO:0072359] plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] ATLTMTVDRGDNV;EDDFYVEVERRSVQ;GVSLLLSGMVDSAMD;HRGYLYLA;IVRRCEAQKWGPE;PRTEYELCVQLVRRGEGGEGH;TVCMNNGV;VKVLPKPLN 8 9.3 1.003 -2.5508 0 0 0 9.32492 0 10.5177 0 0 0 9.17273 0 0 9.0209 0 0 A0A8C0Q5J6 A0A8C0Q5J6_CANLF Nitrite reductase MB (Pseudoperoxidase MB) Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasm [GO:0016528] heme binding [GO:0020037]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] GQVLSSSSGHACTMGLSDGEWQ;VIGILGSLCPCQSSSNKAPPGLQ 2 15.4 0.91819 0.11501 0 0 0 0 0 9.16078 0 0 0 0 9.5542 0 0 0 0 A0A8C0Q5L8 A0A8C0Q5L8_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] PFPLPLCSTWPWRSCSYE;SGPLPAPRPGP;TPCAQGEENGFPDSTGD 3 13.1 0.98315 0.046227 0 0 4.59616 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q5N2 A0A8C0Q5N2_CANLF Rap-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] EGEAMEECDSGSQP;KFGVIYQKARQT;LVRWYVQEGRFRIE;SQMIVSYDEHDVNNTFKFG;VESVYTVFR 5 8.4 0.94097 0.060971 0 0 0 0 0 0 0 0 0 0 0 0 0 8.24859 0 A0A8C0Q5N4 A0A8C0Q5N4_CANLF Nucleoprotein TPR TPR Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] nuclear periphery [GO:0034399]; nuclear pore [GO:0005643] DDDDDEDDTGMGDEGED;DDDEDDTGMGDEGEDS;DDENDGEHEDYEEDEEDD;DEEDDDDDEDDTGMGD;DEEDDDDDEDDTGMGDE;DEEDDDDDEDDTGMGDEGED;DEEEDDDENDGEH;DENDGEHEDYEED;DLQDRTTQEEQLRQQ;DSIGEGVTQGDYTPMEDSEET;DYEEDEEDDDDDEDDTGMGD;DYEEDEEDDDDDEDDTGMGDEGE;EAQNKYERELMLH;EDDDDDEDDTGMG;EDDDDDEDDTGMGDEGEDS;EDDDENDGEHEDYEEDEEDD;EDLIFRIVEEEEE;EDYEEDEEDDDDDEDD;EEDDDDDEDDTG;EEDEEDDDDDEDDTGMGDE;EEDEEDDDDDEDDTGMGDEGEDS;EEEDDDENDGEH;EEEEEEEEEDSWFSETECSI;EESMGGGE;ENDGEHEDYEEDEEDDDDDEDDTG;ESSFSQDISREQQPSSASERQTP;FGSTSGSV;GEHEDYEEDEEDDDDDE;HEDYEEDEEDDDDDEDDTGMGDEG;IDSDDEEEDDDENDGEHEDYEE;IDSDDEEEDDDENDGEHEDYEEDE;IHAPPQELGPPVQ;LDEIVKEVEAKAPI;LSVKLEQAMKEIQRLQ;LVNETRECQSLRLD;LVSQQKDPDTEEYRKLL;NEGTGSADGNDGYEAD;QDSLNAER;TDELLALGREK;TETMNVVMETNK;TPLFLAHEE;TQVESQEAMQSEGP;VEEEEEEEEEDSWFSETE;VIDSDDEEEDDDENDG;VSKCMSRCEDLEKQNRL;YEEDEEDDDDDE 46 13 1.0028 -2.5568 0 11.0875 6.0398 11.0986 10.1652 11.9055 8.17652 10.8546 10.0247 11.4848 11.0055 12.329 9.96355 9.15522 10.4027 A0A8C0Q5N9 A0A8C0Q5N9_CANLF Ankyrin repeat domain 10 ANKRD10 Canis lupus familiaris (Dog) (Canis familiaris) CVSALVANG;VKKARTEAQ 2 4.7 0.98612 -0.41471 0 0 0 0 0 0 0 0 0 0 0 0 8.93029 9.82933 8.25545 A0A8C0Q5P4 A0A8C0Q5P4_CANLF Tumor necrosis factor alpha-induced protein 8-like protein 1 TNFAIP8L1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737] FEDLPSPIPPGQGPG;LDGASTVGPTDRPRRAGPMD;TRSRKEAQKVLKNLVKV 3 13.6 0.99272 -0.068193 0 0 0 9.61344 7.91773 0 0 0 0 0 0 8.34478 0 0 0 A0A8C0Q5P5 A0A8C0Q5P5_CANLF Vesicle transport protein SFT2D1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] TGLLWLPGG;VLSGQDDEEQGLT 2 13.8 0.98697 -0.49949 8.67532 0 0 0 0 8.30305 0 0 9.74948 0 0 0 0 0 0 A0A8C0Q5Q9 A0A8C0Q5Q9_CANLF Transient receptor potential cation channel subfamily M member 5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ALVSDKPE;DLSRRSENPWRD;FCWEDIVHWT;GSPSCPNLYANWLV;IVERMMKDVFFFL;LCAFLCPALIY;PEPLDQKMVTWE;QEGSEELDTVI;VAYGVTTQ 9 8.6 0.99206 -0.17088 0 0 0 0 0 0 0 7.54442 7.72096 0 0 0 0 0 0 A0A8C0Q5S8 A0A8C0Q5S8_CANLF Family with sequence similarity 110 member D Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GKRALCPTCSLPLSEKE;LCPTCSLPLSEKERFFNYCGLERAL;PGSGDTSDWTSSDGD;VEVLGAERFSPQSWGADASPQPG 5 27.4 0.19658 0.76283 9.04182 9.22238 10.4963 0 0 9.17879 0 11.2543 0 0 0 0 0 0 10.6677 A0A8C0Q5T5 A0A8C0Q5T5_CANLF Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) MED1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to thyroid hormone stimulus [GO:0097067]; positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coregulator activity [GO:0003712] MVKKNLPPASSPGVLPF;SEKLSKMS;TIEGTSAMYKLPIAPLIMGSHP;VLPFLVISSQQLCH;VTSLPAMTD;VVQRCMSIPVT 6 12.2 1.0034 -1.9634 0 8.16787 6.92029 9.46477 11.4509 8.09371 0 0 0 0 9.47409 8.47752 0 8.70929 6.94216 A0A8C0Q5T7 A0A8C0Q5T7_CANLF DDB1 and CUL4 associated factor 6 DCAF6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654] nuclear receptor coactivator activity [GO:0030374] DDSDDDPVLIPGA;RLRSRYLGRREFIQRLKLEATLNVH 2 3.9 0.98915 -0.21852 0 0 0 0 0 0 0 4.88098 0 0 9.54986 0 0 0 0 A0A8C0Q5U6 A0A8C0Q5U6_CANLF Microtubule associated protein 1B Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule [GO:0005874] microtubule binding [GO:0008017] EDGGYAYD;ESPFEGKDGKQGFAD;ESSPLYSPSF;ETSEKTMRTPE;FMQQWTGTNKDKAE;KPTTDVKPKVTKEKTVKKE;LDDISNGYDD;LSKPCCYI;TFQETEMSPSKEECPRPMS;TQKDLTGQVAAPAVKQVKLK;TRTPQAATYSY;TTNSDWMKNLISPDLGV 12 6.6 1.0023 -1.4581 0 10.296 8.5705 9.0258 7.75916 6.60561 11.7611 0 0 0 0 9.53206 0 0 6.03333 A0A8C0Q5V0 A0A8C0Q5V0_CANLF protein-ribulosamine 3-kinase (EC 2.7.1.172) FN3KRP Canis lupus familiaris (Dog) (Canis familiaris) kinase activity [GO:0016301] VTCCGYLP 1 2.7 1.0048 -1.1044 0 0 0 0 0 0 7.43321 0 0 0 0 0 0 0 0 A0A8C0Q5W0 A0A8C0Q5W0_CANLF Guanylate kinase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAGGEEYGDDCEGE;ESDAGGEEYGDDCEGE;GLENHDFLEVINLED;HSPQPDQDEESGE;IQRETTERPGHL;KLTTFFNFKPP;LSPNQKEEDV;PGYFDAIINADDLEVAYQKLSQL;SDLSSEILTTNVP;SEALQGSGPTSPSLRRTQDKET 10 10.3 1.0018 -0.74225 0 7.77426 0 0 2.66298 7.27956 10.6537 5.02326 13.0363 0 0 12.5458 10.6326 11.1412 9.96242 A0A8C0Q5W1 A0A8C0Q5W1_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AYSVGLVVACYLLPFLLMGFCHYHI;SDGSGGDS;TGAWAGGG;TTQPSIVNCKCQKTT 4 14.2 1.001 -2.7189 0 0 0 9.10242 8.92264 9.72248 0 0 0 8.49422 0 8.50299 0 0 10.8028 A0A8C0Q5W3 A0A8C0Q5W3_CANLF Phosphofurin acidic cluster sorting protein 2 Canis lupus familiaris (Dog) (Canis familiaris) IKEASVKVAEIWI;TAAPPADRK;TLDMENPSDSGPDLEDDD;VEPSSATSGDSDDAAPSGS 4 6.9 1.0022 -1.2367 6.07416 0 0 0 9.48702 0 0 0 12.4093 6.48786 0 0 0 0 0 A0A8C0Q5W5 A0A8C0Q5W5_CANLF Stannin SNN Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] AKLTPNGP;GVVTVIVILIAIAALGALIL 2 32.2 0.99483 -0.15264 0 0 5.54387 0 0 0 7.86505 0 0 0 0 0 6.91241 0 0 A0A8C0Q5X9 A0A8C0Q5X9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GSTPQLQEEAGA;VPEPAGPGTP 2 3.9 0.99455 -0.56102 0 0 10.5578 0 0 0 0 0 0 11.7409 0 0 0 0 0 A0A8C0Q5Y3 A0A8C0Q5Y3_CANLF Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) PRPF6 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" DDDDEDLNDTNYDEFN;EALRHYEDFPKLWMMK;EKLTPVPDSFFAK;FNGYAGSLFSSGP;LAEVTEEEWL;SPAPRPRRDLHGIH;YENARKVLNKARENIPTDRHIWIT 7 8.2 0.94084 0.061036 0 0 0 7.83105 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q5Z2 A0A8C0Q5Z2_CANLF Endoplasmic reticulum metallopeptidase 1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] endoplasmic reticulum membrane [GO:0005789] metalloexopeptidase activity [GO:0008235] DLAFIENGYIYHTKYDT;GGGGGGGA;GGGGGGGG;PEGMVTVAIAAHYLSG;QHMTRTFHDLDGNVIKRDSGIWIN 5 9.4 0.98772 -0.50388 0 0 0 0 0 0 0 0 0 0 7.07339 0 0 10.8871 0 A0A8C0Q602 A0A8C0Q602_CANLF C2 domain-containing protein SYT7 Canis lupus familiaris (Dog) (Canis familiaris) calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059] plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149] DPEAAGPG;GGTMYRDPE;KVWLMYKDKRVEKKKTVTMKRNLNP;TRRAGRREAARL 4 6 1.0029 -1.3462 10.7322 0 0 5.65461 4.53493 0 0 0 0 0 0 0 0 0 0 A0A8C0Q616 A0A8C0Q616_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EANADDFVHIYSEGN;LPLHGSHIMPKNGL;LSFILPKEYTHRF;LVMLPSYNFAMSISKFFNDYEMKKL;MDAFVANYNFLDT;SVVFLDEPSTGLDP;VFLDEPSTGLDPV;WNTITWMCRSK 8 6.6 0.93695 0.060873 0 0 0 0 0 0 0 8.89942 0 0 0 0 0 0 0 A0A8C0Q632 A0A8C0Q632_CANLF Calponin CNN3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; actomyosin structure organization [GO:0031032] actin cytoskeleton [GO:0015629]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516] DQTTISLQMGTNKGAS;PPGCNLPPRCSRPR 2 4.4 0.9949 -0.12846 0 0 0 0 0 0 0 0 0 0 0 9.38688 0 0 0 A0A8C0Q659 A0A8C0Q659_CANLF Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) PRPF6 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" DDDDEDLNDTNYDEFN;EALRHYEDFPKLWMMK;EKLTPVPDSFFAK;FNGYAGSLFSSGP;LAEVTEEEWL;STLGHLSPQ;YENARKVLNKARENIPTDRHIWIT 7 10.2 0.99421 -0.010031 0 3.56572 0 9.56304 9.78121 0 10.0482 0 0 11.7006 0 0 8.06248 0 10.0301 A0A8C0Q664 A0A8C0Q664_CANLF "RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing" Canis lupus familiaris (Dog) (Canis familiaris) intracellular cholesterol transport [GO:0032367] trans-Golgi network [GO:0005802] ALVRCTAARMFELCQ;DHKDSEDSGQN;DPSERVVSATHQVFLPAYA;EDVMTLLSLSHA;GEAAAAAALGGCGETPGRL;VAESCGAL 6 8.1 0.99203 -0.54985 0 0 6.58988 5.92678 0 0 0 0 8.37108 0 0 7.87295 3.6133 0 9.01399 A0A8C0Q687 A0A8C0Q687_CANLF Rho GTPase activating protein 18 ARHGAP18 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AGDPQESMVFLSTLTR;NEPDEGELEEEWL;VGGPGGKG 3 6 0.99002 -0.26592 10.8315 0 0 0 0 0 12.2029 0 0 0 0 0 0 0 0 A0A8C0Q694 A0A8C0Q694_CANLF Uncharacterized protein ACTE1 Canis lupus familiaris (Dog) (Canis familiaris) EKMSQILFETFNVPALYLANQG;YSTYSAWVGGSIL 2 10.7 0.93044 0.10697 0 0 0 0 0 7.8327 0 0 5.04343 0 0 0 0 0 0 A0A8C0Q6B2 A0A8C0Q6B2_CANLF TNFR-Cys domain-containing protein TNFRSF1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] tumor necrosis factor receptor activity [GO:0005031] ETLLENPEDKPLPLGVP;PDDQQVPFSQEECP;SSGSDHGP 3 8.9 1.0023 -0.99146 0 0 0 0 7.13463 0 10.3113 0 0 0 0 0 6.35866 0 0 A0A8C0Q6B9 A0A8C0Q6B9_CANLF Transmembrane 9 superfamily member TM9SF1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome membrane [GO:0000421]; lysosomal membrane [GO:0005765] ELYYIFATVWGREQYTLYGILFFVF;ESLYEIRFRE;ETSVERRSDRRRGDDGGF;GSGDDFDQGDNGW;LDEETTSA;LYYFEFVVDDLPIRGFVG;PATTILLLLTVWLLVG;TKNIAREIPPQPW;WLSIINSMVLVFLLV;YRWWWRSVL 10 23.9 1.0031 -1.7406 9.22079 9.88786 4.0115 8.45594 0 0 10.0833 8.49941 0 0 0 0 6.47939 7.8558 0 A0A8C0Q6D7 A0A8C0Q6D7_CANLF Equatorin Canis lupus familiaris (Dog) (Canis familiaris) acrosomal vesicle exocytosis [GO:0060478]; endocytosis [GO:0006897]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] plasma membrane [GO:0005886] CGAMLYKVKTISYKERCQEQYPVN 1 8.4 0.99167 -0.28769 0 0 0 0 0 0 0 0 11.5834 0 0 0 0 0 0 A0A8C0Q6D8 A0A8C0Q6D8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GQSGPGSSGSFGQSGKGPVNGQ;RLSVSSDHL;SEAGSSLAHNQFGYSIS 3 5.5 0.98767 -0.48126 0 0 0 0 7.96665 0 0 0 10.4469 0 2.70794 0 1.80781 3.53144 0 A0A8C0Q6E3 A0A8C0Q6E3_CANLF Keratinocyte differentiation factor 1 KDF1 Canis lupus familiaris (Dog) (Canis familiaris) keratinocyte development [GO:0003334] EEYYSFHESD;KSTMGSSFSYPDVKLK;RLGPWEQPTELCLETF 3 11.3 1.0039 -0.81474 10.6914 0 0 0 0 0 0 0 0 0 0 0 5.6881 0 6.54427 A0A8C0Q6F5 A0A8C0Q6F5_CANLF RAVE complex protein Rav1 C-terminal domain-containing protein DMXL1 Canis lupus familiaris (Dog) (Canis familiaris) AEEELLNMLPAMQKED;ATYKSILRKKVL;DDDDDDDDDDVLASDFHLQ;DDDDDDVL;DELFQIPTL;ESDDDDDDDDDDDVL;ESLESDDDDDDDDDDD;HPLQLLELMDLGKVRRAK;ITSLSLSENNEKSGP;KRCLNESLEDNCET;LESDDDDDDDDDDDV;NPGDHCFSVGSVGDQRFTAY;SDDDDDDD;SDDDDDDDD;SELARINSLHVSAFS;SLESDDDDDDDDDD;TDSLSTLDENDIL;WHVDWLDEYQPGM;WSKNADMLFSI;YCSDGEDL;YDSEESLESDDDDDDDDDDDV;YVMHTLAA 22 6.6 0.85759 0.15491 0 0 0 0 0 0 0 0 3.98878 0 0 0 5.79966 5.68417 0 A0A8C0Q6F8 A0A8C0Q6F8_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HVLIHTNIRAYQ 1 1.8 0.99222 -0.17128 10.3778 12.2685 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q6G0 A0A8C0Q6G0_CANLF Axonemal dynein light chain domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DLVTQRMMDQRIL;DQIARQMIDFYKDLVTQRMMDQRI;EETRPLEHSQ;EKEDDEEEQEEEE;LMAERDLWSSA 5 5.8 0.94204 0.059561 5.06445 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q6H4 A0A8C0Q6H4_CANLF Voltage-dependent T-type calcium channel subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AEGDANRSYSDEDQSSSN;AKILGVLRVLRLLRTLRPLRV;ASRSSSAG;EGDANRSYSDEDQSSSNMED;FVFFAMEMVL;GAGGGGGG;GAKILGVLRVLRLLRTLR;GVLRVLRLLRT;GVLRVLRLLRTLRPLRV;GVLRVLRLLRTLRPLRVI;LAFIFLNCITIAL;LSVLRTFRLLRVLKLVRFM;QGDVALPPYYQPE;RLLRVLKLVRFM;RQAGAAAG;RVLRLLRTLRPLRVISRAPGLKL;SGGGSEEA;TVRVLRPLKAIN;VEYSLDLQNINLSAI;VLRLLRTLRPLRVISRAPGLK;VLRVLRLLRTLRPLR;VLRVLRLLRTLRPLRVISRAPG 22 7.8 0.99836 -3.29 13.2577 11.3916 12.1726 0 12.8629 11.6204 0 14.2232 9.98157 5.65418 13.8808 13.8725 13.9158 10.8656 13.4181 A0A8C0Q6I5 A0A8C0Q6I5_CANLF Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAREDLFCYWEK;ELHGEGDQDE;ETRKGKKE;EVIDVHNRVRMVTVG;LTTGAASISPGSSM;MSSVGAST;RKPTKILELTRLLPLKFV;TGAASISPGS 8 14.4 0.99899 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.96842 A0A8C0Q6J6 A0A8C0Q6J6_CANLF DNA replication licensing factor MCM3 (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386] EENNPLETEYGLSVYKDHQ;HVLRMHRYRAPGEQDGD;IAKIKKFSKT;VLRMHRYRAPG 4 5.6 1.0023 -0.74005 9.5734 0 0 9.85764 11.8976 0 0 4.74422 0 0 0 0 0 0 0 A0A8C0Q6K9 A0A8C0Q6K9_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] APPCCQLCPDGGGG;GGGGGGGG;TKIETLRLAIRYI;VPAGSPEPSPGRPGGPA 4 18.3 0.85714 0.17261 0 0 0 0 0 0 0 6.50676 0 4.7751 4.80509 0 0 5.2788 0 A0A8C0Q6L3 A0A8C0Q6L3_CANLF PIH1 domain-containing protein 2 Canis lupus familiaris (Dog) (Canis familiaris) PEPQLCLQSRILK;RMKQNLMGMQAHPTDLREKM;VLISVGKPED;VVPGPVTV 4 9 0.99277 -0.13997 12.9169 13.1683 0 0 10.2295 12.0001 13.1209 12.8531 8.75405 0 0 13.3292 0 0 0 A0A8C0Q6M4 A0A8C0Q6M4_CANLF Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) ECHDC1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] catalytic activity [GO:0003824] EARAWLGQFTQGPPQVIRALKRSVS;SATPQGKQLQGLQGLG 2 13.1 0.97575 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 7.31016 0 A0A8C0Q6M9 A0A8C0Q6M9_CANLF Transcriptional regulating factor 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AALEMLLLRKPVRLK;FDAKNKLTCSICLKEFKS;QHLQEQQQQ;RKPVRLKCHPLANYHY 4 4.5 0.98475 -0.44487 0 4.09424 0 0 0 0 5.57477 14.2348 0 0 0 0 0 0 0 A0A8C0Q6P4 A0A8C0Q6P4_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] APSTVAPVVGLGKMGNG;KRSREESRSRSRSRSRSKSER 2 6.9 0.93603 0.093818 0 0 0 4.00324 0 0 0 0 9.63254 0 0 0 0 0 0 A0A8C0Q6S8 A0A8C0Q6S8_CANLF "Fructose-1,6-bisphosphatase isozyme 2 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)" Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094] anchoring junction [GO:0070161]; nucleus [GO:0005634]; Z disc [GO:0030018] "fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; metal ion binding [GO:0046872]" GVDLFMLDPALGEF;PLILGSPDDVQ;SALPTARASQRARVS;TPKEKRGK 4 11.1 0.98398 -0.24744 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.79466 A0A8C0Q6T3 A0A8C0Q6T3_CANLF Receptor-type tyrosine-protein phosphatase V-like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AKESLTSKMLEA;CAVAGPWRAVGPH;EATGMALTWTV;PSDLAIGWAPAPGPRE;PYDHSQVR;VPLPAAVG 6 4.2 1.0029 -2.312 0 0 0 0 8.06102 9.21001 0 0 0 0 9.588 0 9.74078 9.71464 0 A0A8C0Q6U1 A0A8C0Q6U1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHNHYTQKSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;EALHNHYTQKSLSHSPG;EDGSYFLYSKL;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;FIFPPKPKDTLL;FLYSKLSVDKSR;FPPKPKDTLL;FPSVLQSSGL;GGPSVFIFPPKPKDTLL;GPSVFIFPPKPKD;GPSVFIFPPKPKDTLL;GRVPRPPD;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GTYRVVSVLPIGHQD;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HNHYTQKSLSHSPG;HTFPSVLQSSGL;HYTQKSLSHSPG;IFPPKPKD;IFPPKPKDTLL;IFPPKPKDTLLIAR;KLSVDKSR;LHNHYTQKSLSHSPG;LPSPIERTISKARG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTQKSLSHSPG;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;PEDPEVQIS;PPKPKDTLL;PSVFIFPPKPKDTLL;QKSLSHSPG;QLVESGGDLVKPG;QSSGLYSLSSM;RTTPPQLDED;RTTPPQLDEDGSYFL;SGGDLVKPG;SGGDLVKPGG;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TFPSVLQSSGL;TPPQLDEDGSYFL;TQKSLSHSPG;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TTPPQLDEDGSYFL;TYRVVSVL;TYRVVSVLPIG;TYRVVSVLPIGHQD;VESGGDLVKPG;VESGGDLVKPGG;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VMHEALHNHYTQKSLSHSPG;VQLVESGGDLVKPG;VRQSPGKGLQ;VTVPSSRWPSET;VTVSWNSGSLTSGVHTFPSVL;VVSVLPIGHQD;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTQKSLSHSPG;YVLPPSRE;YVLPPSREE;YVLPPSREELSK 127 42.9 0 323.31 18.7842 18.9193 18.9459 17.1581 17.3203 17.4273 18.5222 18.6521 18.6246 17.5079 17.9754 18.0745 18.1001 18.1325 18.1742 A0A8C0Q6V0 A0A8C0Q6V0_CANLF Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) ELOVL4 Canis lupus familiaris (Dog) (Canis familiaris) "fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum membrane [GO:0005789] fatty acid elongase activity [GO:0009922] LNLFIFRELFMG;VSTALNDTVEFYRWTWSIT 2 10.4 0.98943 -0.21617 9.66155 10.0688 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q6V2 A0A8C0Q6V2_CANLF 40S ribosomal protein S19 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LSRDSTPDLRA;SSKLKTPLATRP;VGSVTKVSWGRQRNGVMPSHF 3 18.5 0.98551 -0.44633 0 10.1372 0 0 0 6.60406 0 0 0 0 0 0 0 0 0 A0A8C0Q6W0 A0A8C0Q6W0_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] ACSRLSRAHLQTRKPRRGGGGV;EALKASNGDI;NWRFEQEVEEW;PSAEIIVL;YKKWHEDYSLFRKVSVY 5 4.3 0.98611 -0.42337 0 0 0 0 0 0 10.1946 11.0054 0 7.36571 7.23611 0 0 0 0 A0A8C0Q6X1 A0A8C0Q6X1_CANLF Pre-rRNA-processing protein TSR1 homolog Canis lupus familiaris (Dog) (Canis familiaris) "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" "nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" GTP binding [GO:0005525]; GTPase activity [GO:0003924]; U3 snoRNA binding [GO:0034511] DEDGESDGEDEYDD;DPGVTMEICAMDAVADMEE;EPVKAKEDLIFHCG;KEEEEEYETMTM;SLPEAFRLLQDTD 5 9.2 0.67905 0.28122 0 0 0 0 0 4.90193 0 0 0 8.55205 9.09877 5.15874 8.6494 0 0 A0A8C0Q6X3 A0A8C0Q6X3_CANLF DNA-directed DNA polymerase family A palm domain-containing protein POLN Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] AEQALVPSVEGVAML;DELLFEVE;LDDMEKSQLIEM;VQTTIAQCHQTGSAA 4 5.7 1.0011 -0.94538 0 0 0 10.3924 10.5967 9.60984 0 0 0 0 7.43538 0 0 0 8.88813 A0A8C0Q701 A0A8C0Q701_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MFSTLTVSNLSLEDTS;QCKIPEVQRPATLMS 2 16.6 0.99679 -0.10961 0 0 0 0 0 0 0 0 0 0 9.10389 0 0 9.62328 0 A0A8C0Q709 A0A8C0Q709_CANLF BTB domain-containing protein BTBD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] IHIPDVEP;PAGGGAGP;PRPRPRPREPEP;RPPRPHAAAPGLPARPGGAVPHG;RSNQWRYRGRCDSIQ;VTCGRRGGRGE 6 9.8 1.0032 -2.0879 0 0 0 0 8.30095 12.0371 0 0 0 0 8.51353 0 10.4656 0 0 A0A8C0Q719 A0A8C0Q719_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562] antigen binding [GO:0003823] ESGGDLVKPG;ESGGDLVKPGG;EVKLVESG;EVKLVESGG;EVKLVESGGD;EVKLVESGGDL;EVKLVESGGDLVKPG;EVKLVESGGDLVKPGG;KGVQGEVKLVESGGDLVK;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG 16 19.3 0.98706 -0.23501 0 0 0 0 0 0 0 0 0 0 0 0 8.02165 0 0 A0A8C0Q722 A0A8C0Q722_CANLF ETAA1 activator of ATR kinase Canis lupus familiaris (Dog) (Canis familiaris) LFCGKTNQQQ;QDCAVASNLTKLE;TKITQSLEKNKTPINL 3 4.2 0.98778 -0.48485 0 0 0 0 0 6.15498 0 0 0 0 0 0 0 0 11.5472 A0A8C0Q732 A0A8C0Q732_CANLF Glutamate receptor GRIK3 Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" kainate selective glutamate receptor complex [GO:0032983]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EDGLEKVGV;IFEYADGPN;LAYLGVSCVLFVI;VSILYRKPNGTNPSVF 4 5.3 1.004 -1.0807 0 4.48723 0 0 0 0 0 8.67069 0 0 0 0 10.1875 9.78229 0 A0A8C0Q735 A0A8C0Q735_CANLF Proline and serine rich 2 PROSER2 Canis lupus familiaris (Dog) (Canis familiaris) VLVRFPEKEDRS 1 2.5 0.95322 0.05044 0 0 0 0 0 0 0 9.29193 0 0 0 0 0 0 0 A0A8C0Q737 A0A8C0Q737_CANLF Translocating chain-associated membrane protein TRAM2 Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" membrane [GO:0016020] KSYPLFSQEF;LLLLQYSTEFLF;RLGLILLLLQ 3 7.3 1.0031 -0.87152 0 0 0 0 0 0 0 0 0 4.2791 0 0 0 9.72112 0 A0A8C0Q761 A0A8C0Q761_CANLF adenylate cyclase (EC 4.6.1.1) ADCY3 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to forskolin [GO:1904322]; flagellated sperm motility [GO:0030317]; intracellular signal transduction [GO:0035556]; olfactory learning [GO:0008355]; sensory perception of smell [GO:0007608] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] AFFVFSFFIT;AVAVINIYAWRP;IFVMMLSFY;LMGLAMVEA;LPLVPSKYS;NQGFSEPEY;RHFLGSKKRDEELYSQSYDEIGVM;RVTRKVVPYLLWLLI 8 8.5 1.0026 -1.3532 11.2649 14.9025 14.8776 13.6055 0 8.39703 9.99209 13.4276 8.29999 0 0 0 9.50052 0 0 A0A8C0Q775 A0A8C0Q775_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] SSPESRATKTILLLVSTFVCC;VLSLFDNPNKLL 2 10.5 0.92076 0.1194 0 0 0 0 10.4112 0 0 0 11.5527 0 0 0 0 0 16.5002 A0A8C0Q7A5 A0A8C0Q7A5_CANLF Anion exchange protein SLC4A2 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;GEKTQDLIGVSELIMS;GETPTIEEGEEDEEEASEAEG;HPSDEKDFSFP;PGASPTGETPTI;PGFPEQEDDEL;PQAVSEAGS;RSQPEPESLGP;SDPHVTEPLIGGVPETR;SEAEGTRALSQ;SSVQFFLQ;SSVQFFLQE;TAPEKRGWVINPL;VEVAGAVEDDPLRR;YGEEDFEYH 15 12.1 0.99217 -0.27195 9.95865 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q7B2 A0A8C0Q7B2_CANLF Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein AP3B2 Canis lupus familiaris (Dog) (Canis familiaris) anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] axon cytoplasm [GO:1904115]; membrane coat [GO:0030117] EQQDLALLSISTFQ;ISTFQRGLKMLRMMV 2 17.3 0.98371 -0.24378 0 0 11.268 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q7C2 A0A8C0Q7C2_CANLF Leucine rich repeat containing 40 LRRC40 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EEAHWRPCKNYGPRL;EGFEQLFNLED;GVRGWCWGRGVGGGVG;LEDLDISN;LENLQKLNV;LENLQKLNVSH;LGCWWGGDDIGE;QEVLKYLRSKIK;VGGDVGGVSVGVGWE;VGVGVGVL 10 9.6 1.0023 -1.1859 11.2088 10.1331 8.60103 0 0 8.10894 0 0 0 0 0 7.50637 9.28244 10.3287 8.8166 A0A8C0Q7D6 A0A8C0Q7D6_CANLF Granulocyte-macrophage colony-stimulating factor (Colony-stimulating factor) CSF2 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] granulocyte macrophage colony-stimulating factor receptor binding [GO:0005129]; growth factor activity [GO:0008083] LNNSNDVTA 1 6.7 1.0035 -0.80421 0 0 0 0 0 8.58173 0 0 0 0 0 0 0 0 0 A0A8C0Q7F6 A0A8C0Q7F6_CANLF WD repeat domain phosphoinositide-interacting protein 3 (WD repeat-containing protein 45B) Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site membrane [GO:0034045] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]" EKQEFLEGGVG;GTHTGHVQL;HTLGCFAC;NPHQLHVFETCY 4 10.1 1.003 -1.3284 0 0 0 0 0 0 0 0 0 0 0 0 15.1232 7.8653 0 A0A8C0Q7G9 A0A8C0Q7G9_CANLF MARVEL domain-containing protein SYNGR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGKAGGAF;KDLTFQEEYS 2 9.4 1.0031 -0.87738 0 8.04734 0 0 0 0 12.1944 0 0 0 0 0 0 0 0 A0A8C0Q7I0 A0A8C0Q7I0_CANLF SH2 domain-containing protein SLA Canis lupus familiaris (Dog) (Canis familiaris) PFPICSCSSSEGG 1 4.9 0.93997 0.059561 5.58592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q7J0 A0A8C0Q7J0_CANLF Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] AEDLEDSLASS;DINRALKEN;EVSKDSIFVKILQ;GVSILAEDLEDSL;GYVSQLKSLDRSCDQERY;HYFAKKKTLLGLSKLAALAS;MVTREGAI;QHGIVLKVVYPQ;SEKQAHSWD 9 9 1.0043 -1.0923 10.3549 0 0 0 0 0 9.12954 0 0 2.15727 10.3784 0 7.93446 3.55949 8.86127 A0A8C0Q7J4 A0A8C0Q7J4_CANLF Receptor tyrosine kinase like orphan receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ARSNPLILMRLQLPKCEALPLPE;EALPLPESPD;KASASTPQRRQ;NVSNARYGGPKQKAQPFPQP;PVPAYGAYLSNFYPVQ;QQVPAQVVPKPGSHHSGSGR 6 10.5 0.95336 0.049465 0 0 0 0 0 0 0 0 0 0 7.97384 0 0 0 0 A0A8C0Q7L9 A0A8C0Q7L9_CANLF glutathione transferase (EC 2.5.1.18) LOC610304 Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364] PQAPAPRREGGEP 1 5.6 0.94085 0.059851 0 0 0 9.42154 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q7N0 A0A8C0Q7N0_CANLF DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) NEIL3 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; lyase activity [GO:0016829]; zinc ion binding [GO:0008270] LVKMIRDFSILFYRCR;TAFGTTTLVMVDFSNKSSGL 2 6.5 0 1.3036 11.7916 12.4929 0 6.02368 0 0 0 11.3444 11.6508 0 9.78224 0 12.3605 12.2233 11.1295 A0A8C0Q7Q0 A0A8C0Q7Q0_CANLF CFA20 domain-containing protein WDR90 Canis lupus familiaris (Dog) (Canis familiaris) DELLVTLGDY;ELACVGQCAVTLWLLRGP;LDVATKDGQVVRMSFSNLFK;LEIDHQHMAVRHAR;PGAPPTCE;PGASSSAA;PGPVQESR;PLPEELGAGELTSLC;RCSREGDVAAVT;TRLVSGSNTRRLRL;VGSEDGYLRLWP 11 8 1.0031 -1.9437 12.8924 12.6179 0 0 0 0 6.80516 8.26562 13.3216 0 0 7.48398 6.01491 8.40897 9.25611 A0A8C0Q7R8 A0A8C0Q7R8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ETIMAMMYT;IDPDQRDLF;IPHFFCDM;PSAIGICKV;VLIHLDSHLHTPMY 5 15.7 1.0033 -2.3946 0 0 0 9.50978 0 0 0 0 0 9.12647 0 0 0 4.65867 0 A0A8C0Q7S9 A0A8C0Q7S9_CANLF Striatin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; protein-containing complex binding [GO:0044877] AVAMGSNSECCYSGGADA;EDEDEEDDSEDAI;EDSDEDDD;EMEDEDEEDDSEDAINEF;KGGGGGGS;LVPEMEDEDE;LVPEMEDEDEE;PAGKGGGG;PALPPARPSLWA;PPAPARAL 10 8.6 0.99928 -3.1024 13.3527 13.2581 10.4511 8.41244 12.2026 12.5897 11.1528 0 13.9643 14.0797 9.69818 0 11.4455 11.6759 13.5701 A0A8C0Q7T4 A0A8C0Q7T4_CANLF PWWP domain-containing protein HDGFL3 Canis lupus familiaris (Dog) (Canis familiaris) DLVFAKMKGYPHWPARI;IDELPEGA 2 11.8 0.5508 0.42602 0 0 9.0926 0 0 0 0 0 0 0 9.38782 0 0 0 0 A0A8C0Q7T7 A0A8C0Q7T7_CANLF Immediate early response 5 Canis lupus familiaris (Dog) (Canis familiaris) EPQPERPA;PAGSPAMP 2 5 1.0025 -1.369 6.58582 0 0 0 0 0 0 0 10.2109 0 0 0 0 0 0 A0A8C0Q7V5 A0A8C0Q7V5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;QLNEIETRRTVE 4 5.9 0.94752 0.05044 0 0 5.94806 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q7V8 A0A8C0Q7V8_CANLF Collagen triple helix repeat containing 1 Canis lupus familiaris (Dog) (Canis familiaris) ASPPRLLGLLLLLLLLLLQLR;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLQ;LLLLLLLLLLQLRAP;PPRLLGLLLLLLLLLLQ;RLLGLLLLLLLLL;RLLGLLLLLLLLLL;RLLGLLLLLLLLLLQLR;RLLGLLLLLLLLLLQLRA;SPPRLLGLLLLLLLLLLQLRAP 12 9.3 0.56633 0.40884 0 0 8.1234 0 0 0 5.63008 0 0 5.01801 0 5.19298 7.60481 6.31473 6.59467 A0A8C0Q7Z9 A0A8C0Q7Z9_CANLF Gem nuclear organelle associated protein 5 GEMIN5 Canis lupus familiaris (Dog) (Canis familiaris) AASAYDAAKVLAKKG;ATLECCWTLPSLGGFAY;DESIRESSGPVENGV;EDGSIEIFQVP;EETDPKVSEPE;GVSDQEGEE;GYKDGIVVIIDISKKGEVIHRLR;HRSKEELHQD;LCWHPTKEGCLAFGTDDG;PVSSGFDKS;SLTKKRKARSMLPLTTSL 11 11 1.0027 -2.5103 11.3313 8.64021 8.00051 8.16887 6.42901 8.36207 0 0 0 8.43334 9.29935 8.73867 8.17617 8.52403 4.25111 A0A8C0Q813 A0A8C0Q813_CANLF GLTSCR protein conserved domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAGGGGGG;AGEGAGAGAGAGAARARG;EFETVSTQLLK;FQMPVSLAAGSL;FQMPVSLAAGSLPTQSQP;GGGGGGGA;GGGGGGGG;PPASTSSG;PSVDLDFLEDAILGSPAAG;SPSLPHQAPLGDSPH 10 6.6 0.98707 -0.3638 0 0 0 0 0 0 10.2593 10.4072 11.3319 8.8644 0 0 0 10.1467 9.9714 A0A8C0Q821 A0A8C0Q821_CANLF Bactericidal permeability-increasing protein (BPI) Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular space [GO:0005615] lipid binding [GO:0008289] AEGIEGTPQLWML;DLKGSESLEFLKV;EADLFLSG;VLSQNDFGHPIL;YSSPNRLT 5 9.5 0.98663 -0.38733 0 0 8.67094 0 9.24845 0 0 10.4872 0 8.23989 0 0 0 0 0 A0A8C0Q831 A0A8C0Q831_CANLF PPIase cyclophilin-type domain-containing protein PPWD1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] spliceosomal complex [GO:0005681] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] LQQMRQQLPD;VAASEKST 2 2.9 1.0031 -0.87344 10.2725 0 0 0 0 0 0 0 0 0 0 0 0 9.30761 0 A0A8C0Q838 A0A8C0Q838_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFCRKYRLAQHQRVHTGERPYE;FALFASLG;KFFSQSSSLSEHQRIH;LEANPGQKLCGTQ;TGTRPYECSECGK 5 16.3 0.99832 -0.60406 11.3498 0 0 0 0 7.78143 10.2159 0 0 0 0 0 0 0 14.6159 A0A8C0Q866 A0A8C0Q866_CANLF Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cytoplasmic tRNA adenylyltransferase 1) CTU1 ATPBD3 NCS6 Canis lupus familiaris (Dog) (Canis familiaris) protein urmylation [GO:0032447]; tRNA wobble position uridine thiolation [GO:0002143] cytosolic tRNA wobble base thiouridylase complex [GO:0002144]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] ALCGACFC;EAEVLHTVQ;EGGGAGAGTPGCEGGGGGGRDP;GGGGGGRDP;PGCEGGGG;PGCEGGGGGG;PPETRARP;TAGSGRSRACCTFCGV;YADLFGGWTMDAVA 9 22.1 0.99681 -4.6417 10.2656 0 12.5599 7.16611 11.4566 0 4.62275 11.9506 10.9692 13.0105 0 12.9676 0 0 5.25179 A0A8C0Q869 A0A8C0Q869_CANLF F-box only protein FBXO9 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005] GVGNSYMEDNDD;PASMAEAEEDCHS;SSDLDLRSLE;VLMYIFRWVV 4 8.7 0.98565 -0.43615 0 0 7.50383 0 0 0 0 0 0 0 0 3.75189 0 0 9.471 A0A8C0Q880 A0A8C0Q880_CANLF 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) BCKDHB Canis lupus familiaris (Dog) (Canis familiaris) ATAGRLLRLRAAGA;IVNEAAKYRYRSG 2 12.7 0.9094 0.1206 0 0 0 0 0 0 0 7.07468 0 0 0 0 0 9.41994 0 A0A8C0Q8A0 A0A8C0Q8A0_CANLF DNA-directed RNA polymerase III subunit RPC5 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA transcription by RNA polymerase III [GO:0042797] RNA polymerase III complex [GO:0005666] RRVQSYEFLQKKHAEEPWVHLHYY 1 3.6 0.9729 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.74537 A0A8C0Q8A1 A0A8C0Q8A1_CANLF "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155)" MGAT5B Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] Golgi membrane [GO:0000139] "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]" DNSFMGFVSEELNET;ERIHAYIQHQDFCAAPGP;ESEMNHLYPAF;LFSCAGSS;SEELNETEKQLIR;SLCFLMTSLGG;YPAFAQPGRE 7 10.2 1.0029 -1.6623 0 0 0 0 0 9.9515 0 9.58592 10.4547 10.6164 10.7737 0 11.0502 7.72294 0 A0A8C0Q8A6 A0A8C0Q8A6_CANLF SKI/SNO/DAC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DFGSSLSSSSNSVSSEEEEEEGEE;DHAANDSDFGSSLSSS;RTLVLGKRPVLQTPPVKPN;SEEEDSSTESDSS;TKGEFYSVIESKE;VLKTKRRRV 6 10.3 0.88278 0.13006 11.1337 13.708 11.2309 9.26313 0 0 0 0 13.499 8.42025 13.4658 13.3911 10.4448 13.3232 0 A0A8C0Q8B3 A0A8C0Q8B3_CANLF Plexin domain containing 1 PLXDC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FIVQWDHVYLQGRED;GKTCEDFQDEGH;GRGRGWLLASL;NPSPDVPESRR;VGIVLAVLLVAAIIL 5 14.7 0.9896 -0.214 0 0 0 8.96397 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q8D2 A0A8C0Q8D2_CANLF Myomesin 1 MYOM1 Canis lupus familiaris (Dog) (Canis familiaris) EIEGAPASPLD;EVSWLKNEKP;INEPTPNDKGKYIM;KRAKKSLLS;MFMEKLQD;QFNWSKDYIP;VKAAIAAP;VPIFSGRQVHVSGLTDTEEE;YFIDKCEVG 9 6.4 1.0032 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 13.547 0 0 A0A8C0Q8D8 A0A8C0Q8D8_CANLF Endophilin-A2 (Endophilin-2) Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; podosome [GO:0002102] HPRQAHGTFLWHELPPP;VGGAEGTKLDE 2 7.6 0.9491 0.081718 0 0 0 0 0 0 9.55926 0 0 0 10.049 0 0 0 0 A0A8C0Q8E2 A0A8C0Q8E2_CANLF Prickle planar cell polarity protein 4 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] GESLTPPEP;VLSLGLPCLDTDGASI 2 6.6 0.99206 0.0060505 0 0 0 0 0 15.7182 0 0 16.2454 0 0 0 0 0 12.1539 A0A8C0Q8E6 A0A8C0Q8E6_CANLF GrpE protein homolog GRPEL2 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] mitochondrial matrix [GO:0005759] adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] AGEDCSSEDPPDEL;TLEKIFRGLSLLEAKL 2 13.3 0.95886 0.049233 0 0 0 0 0 0 0 0 0 5.35452 0 0 0 0 0 A0A8C0Q8E9 A0A8C0Q8E9_CANLF Non-specific serine/threonine protein kinase Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of DNA-templated transcription [GO:0006355] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DLAAKKVP;DLWSLGVILYTM;GGGGGGGA;GGGGGGGG;KAKTTEHTRTERQV 5 4.8 1.0029 -1.5871 7.77057 0 10.6682 0 0 0 0 0 0 0 6.08017 0 0 0 0 A0A8C0Q8F5 A0A8C0Q8F5_CANLF P2X purinoceptor Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] DKAFLKSCQFGPKNPYCP;DVMVNGKGAFFCDL;GVEFRTLMKAYG;VGLLYRLLQVSILTYLVVWVFLV 4 16.5 0.9873 -0.32464 0 0 7.51712 0 0 0 0 0 0 0 0 12.5636 0 8.53115 0 A0A8C0Q8H4 A0A8C0Q8H4_CANLF P2X purinoceptor Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] DKAFLKSCQFGPKNPYCP;GVEFRTLMKAYG;VGLLYRLLQVSILTYLVVWVFLV;VIFFCFFFLIYFLLVFNLPT 4 17.8 0.96181 0.048782 0 0 0 7.5821 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q8J6 A0A8C0Q8J6_CANLF Family with sequence similarity 170 member A Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] DILLSGPSGL;QENVPQPESYVVSPG;TDVTEVLDDSHIQ;YVVSPGSEI 4 9.7 0.98751 -0.33864 0 0 0 9.00039 0 0 0 0 0 0 0 8.15289 0 0 0 A0A8C0Q8K5 A0A8C0Q8K5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] TLTCPLVPVPGLP 1 6.5 0.93899 0.059608 0 0 0 0 0 0 0 7.45919 6.67115 0 0 0 0 0 0 A0A8C0Q8L0 A0A8C0Q8L0_CANLF Anoctamin ANO3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] CASRFEYGENCLKG;ESDCYTGP;GLMDEYLEMVL;GLMLEKEPAVANSDIMFI;IIEIRLDAYKFV;KIAYLLTNLE;LFNRWRLEECHP;LQPMNIHGLMDEYLEMVL;PWDTLCKYAE;YKSSQPIKTHGPQNN 10 12.2 1.0016 -1.3121 9.09585 9.36794 8.63376 9.06121 7.98601 7.85056 0 8.84257 12.0963 0 10.3588 8.13042 9.4814 8.64857 8.84348 A0A8C0Q8L1 A0A8C0Q8L1_CANLF GLI family zinc finger 2 GLI2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] ACTREQKPFKAQYMLVVHMRRHTGE;ALASQVKPSAFPQGNLAVVQQKPA;ESSGLCQSSPGAQSSCSSE;GGGGGGGA;GGGGGGGG;IVIHKRSKV;LTALDDTPPGADT;LVVHMRRHTGEKPHKCT;PSDYYHQMTL;VGDMSSMLTSLAEES 10 8.5 1.0022 -1.4593 9.54848 0 0 0 9.67161 6.59465 14.186 5.91834 0 9.41287 0 0 0 0 0 A0A8C0Q8L7 A0A8C0Q8L7_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] KKERDLHSDSFSDKK 1 3.2 0.95298 0.053902 0 0 0 0 0 0 0 6.28101 0 0 0 0 0 0 0 A0A8C0Q8M1 A0A8C0Q8M1_CANLF Cilia and flagella associated protein 74 Canis lupus familiaris (Dog) (Canis familiaris) DIQPNDGFGTILPLETL;DLEDPEYEAEFLPPEAANSA;EFLLPPDAPITI;PTLYFRVMGVAMDVPVW;TLARSFQGKFDK 5 4.9 0.98656 -0.23188 9.64794 0 0 5.87887 0 0 6.25442 10.7151 0 0 0 0 0 6.05274 0 A0A8C0Q8R2 A0A8C0Q8R2_CANLF AB hydrolase-1 domain-containing protein EPHX4 Canis lupus familiaris (Dog) (Canis familiaris) epoxide hydrolase activity [GO:0004301] LHGFPEFWYSWRHQLREFKSEY 1 6.1 0.98954 -0.26543 0 0 0 0 0 0 0 0 11.4035 0 0 0 0 0 0 A0A8C0Q8S1 A0A8C0Q8S1_CANLF Laminin subunit gamma 3 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576] ERLRLQLSPPGA;PHLGAPGA;QPDDCQPCPCPGQ;VAFCTSEFSDIS 4 2.9 1.0033 -1.6173 0 11.6373 0 0 0 0 0 0 6.85499 0 12.452 0 0 0 0 A0A8C0Q8S2 A0A8C0Q8S2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RRDPLIHGGKN 1 3.9 0.98415 -0.25342 0 0 11.7434 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q8T9 A0A8C0Q8T9_CANLF Myelin regulatory factor MYRF Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKNSPSLSLHGRTRRGA;GIGHSKHPKSSEPLASPA;HFQVTVYIGMLGE;LVHYRYKPEF;SGPPIKAEPKAPYAPG;SLLADPVP;YPVLQRDLYMKAEP 7 8.4 1.0032 -0.86728 10.0812 0 0 0 6.73904 0 0 10.1649 15.6619 0 9.87449 0 0 0 11.0402 A0A8C0Q8U4 A0A8C0Q8U4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;CTLGWNVNWCS;ESEKTPNSQGNF;MDAFLESHKL;MNEKGEITTNT 5 5.4 0.97787 0.047792 11.2019 11.4512 11.427 0 0 0 12.1179 0 0 0 7.0782 0 0 0 0 A0A8C0Q8U7 A0A8C0Q8U7_CANLF WD repeat-containing protein 37 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AATPATPAGPRRGEYRRSAAA;CQLVKEYIGHRDGIW;LLLPSLLLSFLLPFYFLPP;PAGPRRGE;PSSLLPSFPPFFLS;SFFLPSSSSFLPSSLLP 6 9 1.0032 -0.86644 8.63121 0 13.7357 0 0 0 10.2354 0 8.0468 3.84338 0 0 0 0 5.17836 A0A8C0Q8V0 A0A8C0Q8V0_CANLF DUF4637 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EEEEEEQTAAPGRREQ;SEEEEEEEEEEEQTA;SVSYCPLRQESS 3 18.4 0.99728 -0.10636 0 0 0 4.96278 0 0 0 9.39279 0 0 0 0 0 0 0 A0A8C0Q8V2 A0A8C0Q8V2_CANLF Actin like 10 Canis lupus familiaris (Dog) (Canis familiaris) AGSTLSRYLRDLL;QEYGSRLVHE 2 9.4 0.98572 -0.246 0 0 0 0 0 0 0 0 0 0 0 0 0 7.68664 0 A0A8C0Q8W6 A0A8C0Q8W6_CANLF IRG-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] IFYLQNYFLETVASDAKVYHRHF 1 6 0.99312 -0.28188 0 0 0 0 0 10.802 0 0 0 0 0 0 0 0 0 A0A8C0Q8X0 A0A8C0Q8X0_CANLF Proliferation-associated 2G4 PA2G4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625] KKKKKKAS;SDQDYILKEG 2 4.6 0.99921 -0.61146 0 0 0 0 0 0 0 0 0 0 0 9.60416 0 0 0 A0A8C0Q8X3 A0A8C0Q8X3_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908] endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; very long-chain fatty acid-CoA ligase activity [GO:0031957] AALLLLPLLLLPLLLLV;AALLLLPLLLLPLLLLVWKL;ALRALRCKRALRKRALAAAAAD;LLLLPLLLLPLLLLVWKLHL;LLLPLLLLPLLLLV;LLLPLLLLV;LLPLLLLPLLLLV;MAALLLLPLLLLPLLLL;PLLLLPLLLL 9 6.9 0.9852 -0.44809 6.34876 0 5.64674 0 0 5.80116 0 0 5.19338 11.0166 0 0 7.46467 0 7.52113 A0A8C0Q8X4 A0A8C0Q8X4_CANLF ZZ-type domain-containing protein DTNB Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] KQAMHVTAKTTCWELTQ;PEKAQQNPTL 2 3.6 0.98268 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.39943 A0A8C0Q8X9 A0A8C0Q8X9_CANLF Myelin regulatory factor MYRF Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKNSPSLSLHGRTRRGA;GIGHSKHPKSSEPLASPA;HFQVTVYIGMLGE;IIAAQILPGAAIV;LVHYRYKPEF;SGPPIKAEPKAPYAPG 6 7.8 0.9943 -0.19098 0 0 0 13.1763 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q8Y1 A0A8C0Q8Y1_CANLF Refilin B Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle organization [GO:0061572]; regulation of chondrocyte development [GO:0061181] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] filamin binding [GO:0031005] AAASPANPAPLPSPL 1 7 0.94662 0.079842 0 0 0 0 0 0 0 10.1932 0 0 0 0 0 0 0 A0A8C0Q8Y7 A0A8C0Q8Y7_CANLF Ig-like domain-containing protein LOC609023 Canis lupus familiaris (Dog) (Canis familiaris) VQHRGRSLM;WDNPSTGLFIVTMIGLKE 2 7.9 0.99405 -0.28489 0 0 8.13837 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q917 A0A8C0Q917_CANLF Serine/threonine-protein kinase mTOR (EC 2.7.11.1) MTOR Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macroautophagy [GO:0016242]; positive regulation of protein metabolic process [GO:0051247]; regulation of cellular component organization [GO:0051128]; TOR signaling [GO:0031929] nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] ALEWLGAD;AVLEAFVYD;DKARDLLDAELTAMAG;DVGSITLALR;ERFDAHLAQAENLQALFVALND;GADRNEGRRH;GGGWCCHG;HEFVFLLKGHE;KGYTLADEEEDPLIYQHRM;MCRDLELAVPGTYDPNQPII;MLRMAPDYDHLTLM;MWKSTRKIDAFQHMQ;PERREIIRQIW;PILKALILKL;PRRQPRPWPEPREPQV;TWLQVIPQLIARIDTPRPLV;VGRLIHQLL;VMAVLEAFVYDPL;YLHLLLPPIVKLFDAPEVPL;YMKNMWKSTRKIDAFQHMQHF 20 9.6 0.99706 -6.5526 11.9044 0 11.0436 10.3232 10.1893 11.8639 11.3753 10.4013 12.5659 8.46508 7.05582 0 7.50621 0 7.86932 A0A8C0Q925 A0A8C0Q925_CANLF Heat shock protein 90 alpha family class A member 1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] EEEKKKQE;KKKKKKIKEKYIDQ;KPIWTRNPDNITNEEYGEF;LGIDEDDPTA 4 16 0.98347 -0.25246 9.31603 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q927 A0A8C0Q927_CANLF WD repeat-containing protein 37 Canis lupus familiaris (Dog) (Canis familiaris) AATPATPAGPRRGEYRRSAAA;CQLVKEYIGHRDGIW;PAGPRRGE;SPQPPAAAPGPMAATPAT 4 5.8 0.98363 -0.25658 8.56178 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q932 A0A8C0Q932_CANLF Capping protein regulator and myosin 1 linker 3 CARMIL3 Canis lupus familiaris (Dog) (Canis familiaris) AGAQALQEQLGTVT;EATWHIAEESAP;EQAGQDIQN;GLFHFRRPRSFKGDRGP;KLRTSILINALGS;PNALMHLDLAG;PRPPRTTPPGPGRPSM;SLKHLFLG;SLQSLSVADSRLKLRTSI;VDTIYHAEDNREFNLLDFSH 10 9.6 1.0029 -2.5485 0 9.99138 4.42129 9.15079 0 0 11.5667 0 8.78914 8.99724 0 0 8.42127 0 9.50249 A0A8C0Q936 A0A8C0Q936_CANLF Transcription factor SOX Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEDDEDDEDDDELQ;EAERLRLKHMADYPDYK;FLDEDDEDDEDDDEL;GCVFLDEDDEDDED;SSSSSGGEDADDLMFDLSL 5 15 0.94082 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.64101 A0A8C0Q938 A0A8C0Q938_CANLF "Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)" SLC14A1 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] urea transmembrane transporter activity [GO:0015204] LVYLHRFGEPEEE;PISGILILVGLL;PVGVGQIYGCDNPWT 3 8.6 0.99257 -0.1657 0 0 0 0 0 0 0 7.55321 5.46881 8.86629 0 0 9.56028 0 6.07421 A0A8C0Q939 A0A8C0Q939_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" MAN1A1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" EAFRFDGGV;KLPEEIQRDIL;KSWVEENLDFNV 3 5.1 1.003 -0.85587 0 9.39829 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q940 A0A8C0Q940_CANLF Transmembrane protein 185B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLFQDFNPSKFL;LDGHNTFSYISIFVPL;VSPVSVAACVWGFR 3 12.1 0.96076 0.049233 0 10.1573 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q948 A0A8C0Q948_CANLF Protamine 3 Canis lupus familiaris (Dog) (Canis familiaris) DNFSLSSEGEEEEEGEE;SEGEEEEEGEEEEEEEEEEEE 2 13.4 0.93486 0.093393 0 0 6.90809 0 0 0 0 0 0 0 0 0 0 4.33077 0 A0A8C0Q956 A0A8C0Q956_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737] phosphatidylinositol phosphate binding [GO:1901981] EDHTWDEHLCTVTC 1 7.9 0.93959 0.060769 0 0 0 8.62073 0 0 0 0 0 0 0 3.66676 0 0 0 A0A8C0Q957 A0A8C0Q957_CANLF Uncharacterized protein CBX7 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LQFQDCWGKR 1 5.3 0.99913 -0.61146 0 0 0 0 10.1813 0 0 0 0 0 0 0 0 0 0 A0A8C0Q958 A0A8C0Q958_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) sulfotransferase activity [GO:0008146] WLQYFPLSQ 1 4.3 0.98991 -0.21161 0 0 0 0 0 9.60201 0 0 0 0 0 0 0 0 0 A0A8C0Q978 A0A8C0Q978_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] AEAVKGRF;ESGGDLVKPG;ESGGDLVKPGG;EVQMVESGGDLVKPG;EVQMVESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG 9 23.1 0 1.7424 0 7.78018 0 0 0 8.02148 10.2046 0 9.81957 9.02464 9.04119 8.86109 0 0 0 A0A8C0Q982 A0A8C0Q982_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LEVNLQNGILFV;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG;VLTYRLSPN;VTLLILVL 6 7.3 1.0017 -1.2864 0 0 7.06178 9.04196 0 11.7486 0 0 0 0 0 0 0 0 0 A0A8C0Q984 A0A8C0Q984_CANLF Mesoderm induction early response protein 1 MIER1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AEIPVGICRYKEN;DEDADNDDNSGCS;EDDEDADNDDNSGCSGE;EDEEEEEEEEEGEDDEDADNDDN;EEEEEEEGEDDEDADNDDNSGCSG;EEEEEEGEDDEDADNDD;EEEEGEDDEDADNDDN;EEEGEDDEDADNDDNSGC;EEEMMEGETNFSSEIE;EEGEDDEDADNDDNSGC;GEDDEDADNDDN;GFFRHSSLPSL;GGGGGGWSP;GVEAIPEGS;SEEDEDYIPSEDW;VAFYYMWK;VESSSPGGSATSDDHEFDPSAD;YGYDSTIRLPEEDEEE 18 20 1.0033 -1.6548 8.55013 6.35834 13.9108 6.77821 5.83294 10.237 9.66583 0 13.7839 7.78162 10.1003 8.01625 10.249 5.92619 7.99407 A0A8C0Q990 A0A8C0Q990_CANLF WD repeat containing planar cell polarity effector Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] EDCEEQEIGDGG;ETHRRVTL;IQQRTLNDSSNRQVLDGRNELEKD;QVLDGRNELEKDT;SILIKIISS 5 7.6 1.0031 -2.362 0 6.52075 0 0 0 9.28302 0 16.3907 0 8.32112 9.19591 0 0 0 0 A0A8C0Q9A3 A0A8C0Q9A3_CANLF Glutamate receptor GRIK5 Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" kainate selective glutamate receptor complex [GO:0032983]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] GAPEPNGS;GGAHGGPQ;SLWAGGLPAGGEWGP;TLGNSLWFPVGGFMQQGSEIMPRA 4 5.6 1.0023 -1.8696 0 0 9.94026 0 0 0 0 0 11.3037 11.7942 0 0 0 0 10.5765 A0A8C0Q9D7 A0A8C0Q9D7_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] ITIAISLWKFET;RLPLQDVYKIG 2 5.3 0.95273 0.05044 0 0 0 0 0 0 0 0 0 9.95813 0 0 0 0 0 A0A8C0Q9D9 A0A8C0Q9D9_CANLF Aquaporin 8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] channel activity [GO:0015267] EGPTLSGDAAGPGPFPRLAGG;GHPGGGCC 2 5.3 1.0031 -1.0572 0 0 4.92951 0 0 0 0 0 10.9546 0 0 0 0 0 0 A0A8C0Q9E3 A0A8C0Q9E3_CANLF "Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln)" Canis lupus familiaris (Dog) (Canis familiaris) cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; spliceosomal snRNP assembly [GO:0000387] cytosol [GO:0005829]; methylosome [GO:0034709]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886] ISLHAVSRDLNAYPREH;MFTVMCECQAWHPDPEDEDSDDYDG;NKCWRGRGENRN;PQGTTIVRSHLSSV;VLVRWLWIRILTGI;WHPDPEDEDSDDYDGDVEAHAEGQ 6 29.4 0.992 -0.065653 0 0 0 0 0 0 7.86319 4.61459 0 0 0 0 9.96339 6.6737 0 A0A8C0Q9F0 A0A8C0Q9F0_CANLF UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3) MFSD14A Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165] GGGEGAGQ;GGSRSVWGTG;LSILTHSLVH 3 4 1.0036 -1.6847 0 0 0 0 6.96832 0 0 0 0 0 0 0 0 0 0 A0A8C0Q9F2 A0A8C0Q9F2_CANLF E3 ubiquitin-protein ligase UHRF (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF) (Ubiquitin-like PHD and RING finger domain-containing protein) (Ubiquitin-like-containing PHD and RING finger domains protein) UHRF1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EDESNTKLWSE;FTYTGSGG;GKGMACVG;LVYRPITTVCQHNVC;QLMCDECDM;VIYHVKYDDYPENGVVQMSSR 6 9.3 1.0039 -2.0371 0 0 0 0 9.88429 6.56694 10.6747 0 0 0 0 0 0 0 0 A0A8C0Q9G1 A0A8C0Q9G1_CANLF Endonuclease/exonuclease/phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] DFNLALSTLDRYSKHSIS;PSICCLQETHFRQ;YSKHSISKETRALNDTLD 3 19.5 0.93273 0.10715 0 0 0 6.99198 0 0 0 9.20499 0 0 0 0 0 0 0 A0A8C0Q9G2 A0A8C0Q9G2_CANLF histone acetyltransferase (EC 2.3.1.48) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleosome [GO:0000786] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] CFKNADPCRNNMD;DNMLFCDSCDRGFHMECCDP;DQSPQIATTLDDCQ;EEEEDEEPSHNEGHDADDEDDSHM;EEEEEEDEEPSHNEGHDADDEDDSH;EEEEEEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEENIQSSPP;ESSEEEEEEEEEEEEEEEE;IKRKRPFVLKKKRGRK;IKRKRPFVLKKKRGRKRRR;IYGRSQTVAMQGP;KPEEEEEEEEEEDDEEE;KRKRPFVLKKKRGRKRR;LTKPQSVAIKRKRPFVLKKKRG;PEEEEEEEEEEDDEEEEEE;PEEEEEEEEEEDDEEEEEEEEEE;RKRPFVLKKKRGRKRRRI;SEEEEEEEEEEEEEEEEEEEEEEEE;SYAQISPDQSAISVPSLQ 19 9.7 0.97842 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 3.75745 0 0 A0A8C0Q9J1 A0A8C0Q9J1_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] WNDGAPGIQHFHQCTEL 1 4.4 0.99139 -0.18128 13.5354 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q9M3 A0A8C0Q9M3_CANLF DUF4709 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LEKSSILQITPEDDI;LREELDRYEESRLQRLDAFAR;SPSLTVATVKTKIVKTPKKSAK;TIKMSILLKKLK 4 13.1 0.99796 -0.10429 0 0 0 8.96498 0 0 0 0 0 9.07727 0 0 0 10.0171 7.97476 A0A8C0Q9M4 A0A8C0Q9M4_CANLF Sosondowah ankyrin repeat domain family member A Canis lupus familiaris (Dog) (Canis familiaris) GVKFVVLKKRLRPRQ;TTSAFLGV;VKFVVLKKRL;VLKKRLRPRQAARALPPGD;YTPLHLAAL 5 7.8 1.0032 -1.9354 0 0 0 8.81631 0 9.25564 0 0 6.55885 0 0 0 0 0 1.8069 A0A8C0Q9Q8 A0A8C0Q9Q8_CANLF Phospholipase A2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543] ADDTRVMPQFAEM;AKLSIDVNCVSK;FCLTSRCPEEFESYGCYCGQE;GVNTHCISLLLWAE 4 13.2 0.93648 0.060903 0 0 0 0 0 0 0 0 0 0 10.0649 0 0 0 0 A0A8C0Q9R6 A0A8C0Q9R6_CANLF SCAN box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QESIPVVETYD;VSWQQESIPVVETYDSEASRQKFR 2 13.2 0.99632 -0.58408 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.48694 A0A8C0Q9R7 A0A8C0Q9R7_CANLF palmitoyl-CoA hydrolase (EC 3.1.2.2) ACOT8 Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637] fatty acyl-CoA hydrolase activity [GO:0047617] AGGGPVLPQ 1 3.1 1.0038 -0.80421 8.806 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Q9S6 A0A8C0Q9S6_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT17 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] GEIGLLDPGMDVYGGENIEL;GGSGSTSA;GSGSTSAH;GWKVATGQVTGFF;IQENRKRVILPS;LARYTKEGFLHLG;YKSHVYIAW 7 12.4 1.0022 -1.3703 0 0 11.6551 0 0 0 0 0 0 0 0 9.44793 0 0 0 A0A8C0Q9V3 A0A8C0Q9V3_CANLF DNA/RNA-binding protein Kin17 WH-like domain-containing protein KIN Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; DNA replication [GO:0006260] nucleus [GO:0005634] double-stranded DNA binding [GO:0003690] IEEEKKRTAR;LDEIMEIEEEKKRTARTDHWLQPEI;LQKLRWYCQMCQKQ 3 9.9 0.9916 -0.17693 0 0 0 0 8.9737 0 0 0 0 0 0 0 0 10.8203 0 A0A8C0Q9X4 A0A8C0Q9X4_CANLF "Methylmalonyl-CoA mutase, mitochondrial (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)" MMUT Canis lupus familiaris (Dog) (Canis familiaris) sulfur compound metabolic process [GO:0006790] cobalamin binding [GO:0031419]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494] DIEKCLEKKQQ;LDDIEKCLE;VDAARARCTVGE 3 3.3 1.003 -0.73086 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5224 0 A0A8C0Q9X8 A0A8C0Q9X8_CANLF Interferon-inducible GTPase 1-like IFGGC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] DVAVIGESGTGKSSFI;IIEESLVAAENAPL;KDVADIIEESL;LVSNFDLDDFDFPRLE;PEPCIFLVSNFDLDDF 5 13.6 0.99654 -0.58341 0 9.42587 0 8.08412 0 9.97111 9.88032 0 11.3422 0 0 0 0 0 0 A0A8C0QA04 A0A8C0QA04_CANLF LIM and cysteine rich domains 1 LMCD1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AGYSKQWHPTCFVC 1 5.6 0.9332 0.060826 0 0 0 0 8.33047 0 0 0 0 0 0 0 0 0 0 A0A8C0QA13 A0A8C0QA13_CANLF Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) BMI1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] PRC1 complex [GO:0035102] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] DEDKRIITDDEIISLSIEFFD;TKPPGPRL 2 4.7 0.98914 -0.2182 11.9824 0 0 0 0 8.77512 0 0 0 0 0 0 0 0 0 A0A8C0QA44 A0A8C0QA44_CANLF "Protein kintoun (Dynein assembly factor 2, axonemal)" DNAAF2 KTU Canis lupus familiaris (Dog) (Canis familiaris) axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285] dynein axonemal particle [GO:0120293] CGGCGGDCRPAGAAGAAAE;DARAGRTAGIEEEPPS;GVKLDRRNAKTLKIK;KLSTREPVASI;PLIEVLEVTES;RPALRRAAP 6 9.2 1.0012 -0.74606 0 0 11.1926 0 0 0 0 0 0 0 0 0 0 8.99848 0 A0A8C0QA50 A0A8C0QA50_CANLF Olfactory receptor OR2AI2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DTGLHTPMYFFL 1 3.9 0.9518 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 9.85597 0 0 A0A8C0QA54 A0A8C0QA54_CANLF Delta-like protein Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] CDAYTCSNGGTCYDS;DCNSCHCMD;DLCDPSPCQNGA;DLDLCDPSPCQNGARCYNLQGD;EDCNSCHCMDGHRD;GACCDGDGRTTRAGGCGHDECDT;GDYYCACPDDVGGKNCSV;GGGGGVTG;GRGRLPRRLLLLL;GVCIDGINWFR;HVAHMELQIRVRC;LPRRLLLLLAL;NSCHCMDGHRDC;VEAWDWDND;VEDCNSCHCMD;VGSGDSFSCIC;VNDFYCACDDGW 17 16.5 0.99728 -3.7912 0 6.93298 7.03133 6.6331 0 9.2902 6.42652 0 9.86549 0 7.50946 0 11.2367 5.22068 6.97808 A0A8C0QA62 A0A8C0QA62_CANLF S100 calcium binding protein A5 S100A5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914] AIVCTFQEYS;ELPTWTPVSTQGCTLSRWGAGGAAR;VGATAAAL;VGGRGGPRGEGGTWHA 4 21.2 1.0021 -1.2815 7.9867 0 0 0 0 0 9.09574 0 0 0 17.1166 0 0 0 10.7271 A0A8C0QA74 A0A8C0QA74_CANLF Cytoplasmic FMR1-interacting protein CYFIP2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell projection assembly [GO:0030031]; regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; synapse [GO:0045202] small GTPase binding [GO:0031267] ETKEPSMMEYV;FGDGLNWAGCSI;KTDVFQSLREVG;MYFQRKAIE;QIFAYYKAMAGS;VGPSSTQLY 6 5.3 1.0035 -1.6346 0 0 0 0 14.033 0 0 0 0 0 0 0 0 3.46963 8.82906 A0A8C0QA81 A0A8C0QA81_CANLF Sodium/hydrogen exchanger Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] calmodulin binding [GO:0005516]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] QETKRSINEEI;SDPGPHPEPGEG 2 2.8 0.98678 -0.23145 0 0 0 0 0 13.0339 0 0 0 9.22243 0 0 0 0 0 A0A8C0QA86 A0A8C0QA86_CANLF Eukaryotic initiation factor 4A-III (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) EIF4A3 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; RNA splicing [GO:0008380]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724] AAAATMAT;VLFVRWGGGSGEPLD 2 4.8 0.99155 -0.54478 0 9.00576 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QA91 A0A8C0QA91_CANLF Protein phosphatase 1 regulatory subunit 17 PPP1R17 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase inhibitor activity [GO:0004864] LELSEDRLDKL;TEALCGGS 2 7.7 0.9894 -0.26592 0 0 0 8.60288 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QA96 A0A8C0QA96_CANLF Rho GTPase-activating protein 35 ARHGAP35 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; lipid binding [GO:0008289] DLRIVMCLMCGDPF;EATHMYDNAAEACST;HSSFSIRKSRL;KNPPVIYKRKKKKLQTS;LMDTVPAEQLY;TDGAIDVL;VIYKRKKKKLQ;VLEETPWDA 8 5.6 1.0029 -2.1153 0 0 11.3514 0 0 0 0 0 0 3.38018 9.59122 16.0465 0 0 10.6083 A0A8C0QAB2 A0A8C0QAB2_CANLF Nidogen 2 NID2 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509] APPSNPCEDGSHTCA;FTGATFTH;GRKGGGDA;GSTSPLDNIRPATIGGDLTKAH;IVSYADHFYHT;QKFWGFLDPS;REGPYFSLTSTEQSVKNLYQQSNL;TDVDECSENRCHPSATCYNT;TEVFTYNAANKETC;VDECSENRCHPSAT 10 9.3 1.0031 -0.87738 0 11.5629 0 0 0 0 0 0 0 0 0 0 0 0 7.77913 A0A8C0QAD7 A0A8C0QAD7_CANLF Collagen alpha-1(I) chain-like Canis lupus familiaris (Dog) (Canis familiaris) LLETPFRGSS 1 2.2 0.9992 -0.61146 0 0 0 0 0 7.39857 0 0 0 7.95292 0 8.73576 0 0 0 A0A8C0QAE3 A0A8C0QAE3_CANLF Testis specific 13 COPG2 Canis lupus familiaris (Dog) (Canis familiaris) SSEGDPPG;VPGSAPAATEGPRSGSSGRPL 2 6.4 0.95008 0.049792 0 0 0 0 7.18299 0 0 0 0 0 0 0 0 0 7.43104 A0A8C0QAE8 A0A8C0QAE8_CANLF Aspartylglucosaminidase Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] AKVPGLSLP;KQEGSTYKETG;SGLTLLLLLLPPLVLGRGP 3 5.3 0.99058 -0.21186 0 0 0 0 0 0 0 0 0 9.51661 7.87977 0 0 0 0 A0A8C0QAG5 A0A8C0QAG5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) PMFRAAMATIATLWKEPWCP;WMKDLNMRQD;WNRIENPEVDPQLYGQL 3 5.9 0.99038 -0.26678 0 0 0 0 0 0 0 0 0 0 0 0 0 9.27998 0 A0A8C0QAI8 A0A8C0QAI8_CANLF Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267]; proton channel activity [GO:0015252] SVRVSCAIIFFASIFQ;VGLLWFAHHSLFL;VLCTRAGRDMVHRCGGVVPSEHAVQ 3 8.1 0.99173 -0.1834 0 0 0 0 0 0 11.9358 0 0 8.03584 0 0 0 0 0 A0A8C0QAK5 A0A8C0QAK5_CANLF GRB2 associated binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) LDLDLDSGKSTPPR;PSAPGPCC;QAPADLPLAVNTAPPSTQVDSSSS 3 4.5 0.98679 -0.39811 11.5187 0 0 9.75764 9.76787 0 0 0 11.8096 0 11.1706 0 0 0 10.0592 A0A8C0QAK7 A0A8C0QAK7_CANLF rhomboid protease (EC 3.4.21.105) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] GGGGGGGE;VGGGGGGG;VLALVCMSSEVGRAVWLR 3 3.4 0.99294 -0.048769 0 0 0 11.7816 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QAM0 A0A8C0QAM0_CANLF "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3" ARAP3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" AADTPDKKEHLVLVETG;CTDEDEMWDWT;DEMWDWTT;EISVVSAADTPDKK;FLPVHIMDP;GVYNEVVVPATYSSFL;KVYLGIRKKLKPPTPW;LGIRKKLKPP;LWVTFEIRE;MHLCLSCTDEDEMWDW;RKRILRLLQ;VGKWFSPLSCHQL 12 7.2 0.99681 -4.4678 6.51341 0 5.1336 5.30433 0 0 0 0 9.7648 0 7.40999 8.75656 9.95899 3.74222 0 A0A8C0QAM2 A0A8C0QAM2_CANLF Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] LDPGAARRRWRRDAERAEC;LKEEHKMFLIRVLLPLHK;MLKDIKKEKVLLRRK;PGAARRRWRRDAERAECG 4 7.8 0.98662 -0.38623 0 0 0 0 0 0 0 0 9.43667 0 0 0 5.47213 10.5951 7.56102 A0A8C0QAP3 A0A8C0QAP3_CANLF Palmitoyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139] protein-cysteine S-palmitoyltransferase activity [GO:0019706] CSVCDNCVERFDHHCPWVG;CVGRRNYRFFYAFI;PDASMCVRGLKDL 3 11.2 0.86364 0.17517 0 0 0 0 0 0 0 0 7.13924 6.51508 8.86743 0 0 0 0 A0A8C0QAP8 A0A8C0QAP8_CANLF Headcase middle domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LDKDDYQKVVC;LDYHFVKPFSSFKVLE;LPRRHSMDRQNSQEKAV;SGDEQENGAG 4 9.9 0.98979 -0.30555 0 10.719 0 6.76553 0 5.94491 0 0 0 0 7.55712 0 0 0 0 A0A8C0QAS6 A0A8C0QAS6_CANLF SSD domain-containing protein PTCH1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hedgehog receptor activity [GO:0008158] AVLALEHMF;EAMFNPQLMIQTPKEE;ENKQLPKMWLHYFRDWLQGLQD;GGGGGEDEDEDGEKDD;LLKPKAKVVVIFLFLGLLGV;TQKVLSFTTTTLDD;VEVVHQSVAP;YKSGELITETGYMDQI 8 8.5 0.96266 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.24878 A0A8C0QAU9 A0A8C0QAU9_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] ILMELMNENKEN;ISHAISVNHVK;SEGSADADSEASEPSSSP;SLQVTDDGQYGD;STVMCEECANISSVNDPFIDISL 5 9.8 0.98736 -0.35462 6.27592 0 0 0 0 0 0 0 0 0 0 10.733 11.3281 0 0 A0A8C0QAV9 A0A8C0QAV9_CANLF GRB2 related adaptor protein 2 Canis lupus familiaris (Dog) (Canis familiaris) FSYQNGGSLDINDGHCGVGMGSEMN;PHPPHSPS;VGEEIRPPMTRKLG 3 14.1 1.0022 -1.3611 0 0 7.37712 0 0 0 0 0 0 0 0 6.69028 0 0 0 A0A8C0QAW0 A0A8C0QAW0_CANLF Nociceptin receptor (Kappa-type 3 opioid receptor) (Orphanin FQ receptor) OPRL1 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218]; sensory perception of pain [GO:0019233] neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; nociceptin receptor activity [GO:0001626] TAVAVLRFCTALGY 1 3.8 0.93547 0.060913 0 0 0 0 8.57939 0 0 0 0 0 0 0 0 0 0 A0A8C0QAX5 A0A8C0QAX5_CANLF Otopetrin 3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] proton channel activity [GO:0015252] ELNTLMENFSGNDT;HLHGVIFGPLLGLMA;LLILQHIVQNLFIIEGLHRRPLWE;YFTLYYAFYIA 4 11.1 0.98851 -0.26447 1.94774 0 0 0 9.26505 8.9655 0 12.0092 0 0 0 0 8.37465 0 11.1444 A0A8C0QAY0 A0A8C0QAY0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) C7H18orf25 Canis lupus familiaris (Dog) (Canis familiaris) motor neuron axon guidance [GO:0008045]; positive regulation of BMP signaling pathway [GO:0030513] PML body [GO:0016605] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] FHQLCVDQWLAMS;SDTLSSAEENEPSQAETAV;SESETSTMAAKKNRQSS 3 6.7 0.98793 -0.40185 0 0 6.21694 0 0 10.8049 0 0 0 0 0 0 0 0 0 A0A8C0QAY2 A0A8C0QAY2_CANLF Glycine receptor alpha 1 GLRA1 Canis lupus familiaris (Dog) (Canis familiaris) "acrosome reaction [GO:0007340]; adult walking behavior [GO:0007628]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; inhibitory postsynaptic potential [GO:0060080]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuromuscular process controlling posture [GO:0050884]; neuronal action potential [GO:0019228]; neuropeptide signaling pathway [GO:0007218]; positive regulation of acrosome reaction [GO:2000344]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]" chloride channel complex [GO:0034707]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; intracellular membrane-bounded organelle [GO:0043231]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; taurine binding [GO:0030977]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; zinc ion binding [GO:0008270] ELLRFRRKRR;FSLAASKEAEAARSAP;LNLFQEDEAGEGR 3 8.5 0.98816 -0.49257 0 0 0 0 0 0 0 0 0 17.0256 17.0463 9.69399 0 0 0 A0A8C0QAZ3 A0A8C0QAZ3_CANLF Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] membrane insertase activity [GO:0032977] SLPMRHRPCDADA;VGVINLLIVEIFA;VLMIPVAAT;WRSPGADMLCRLG 4 9.4 1.0011 -0.62505 0 0 0 0 0 0 0 9.43605 0 9.69326 0 6.854 0 0 0 A0A8C0QB09 A0A8C0QB09_CANLF "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (Complex I-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit)" NDUFS7 Canis lupus familiaris (Dog) (Canis familiaris) "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]" VVSMGSCAN 1 4.5 0.99131 -0.26992 0 0 0 11.3821 11.5355 0 0 0 0 0 0 0 0 10.2055 0 A0A8C0QB10 A0A8C0QB10_CANLF Transmembrane and coiled-coil domains 6 Canis lupus familiaris (Dog) (Canis familiaris) QPSLLPEGLWLLNNLT 1 3.2 0.94902 0.056069 0 0 0 0 0 0 0 0 10.1546 0 0 0 0 0 0 A0A8C0QB15 A0A8C0QB15_CANLF Guanylate kinase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAGGEEYGDDCEGE;EACGKRELAH;ESDAGGEEYGDDCEGE;GLENHDFLEVINLED;IQRETTERPGHL;KLTTFFNFKPP;LSPNQKEEDV;PGYFDAIINADDLEVAYQKLSQL;SDLSSEILTTNVP 9 8.6 0.99906 -0.61146 0 0 0 0 0 0 0 9.09869 0 0 0 0 0 0 7.74625 A0A8C0QB18 A0A8C0QB18_CANLF Rap guanine nucleotide exchange factor 1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] IRWSDQVMLEGVN;LAPPPALP;LKFIKIMKHLRKLNNFN;PKKRQSAPSPTRVA;SPFLGHPFQLPPAPG 5 5.2 1.0033 -1.5209 8.00994 0 0 0 0 0 0 4.46813 0 0 0 0 10.0515 5.77931 0 A0A8C0QB19 A0A8C0QB19_CANLF Glycosyltransferase 2-like domain-containing protein GALNT10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSGAAVVP;VGPPSRAEGVGG 2 3.5 0.95422 0.05044 0 0 8.45648 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QB36 A0A8C0QB36_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FIFSSALRSHQRCHT;KSFSRKYSL;QRLHTGERPYECHDCGKSYTVSSAL;VAYMLRAHCFALVN;VGETLCRNGVDGA 5 5.9 1.003 -0.85793 10.1299 10.6493 0 8.54948 9.18398 0 0 0 0 0 0 0 0 0 0 A0A8C0QB44 A0A8C0QB44_CANLF cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) Canis lupus familiaris (Dog) (Canis familiaris) cytidine deamination [GO:0009972] cytoplasm [GO:0005737] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GARPGGGA 1 3.7 0.98931 -0.26592 0 0 0 10.4603 10.4967 0 0 0 0 0 0 0 0 0 0 A0A8C0QB45 A0A8C0QB45_CANLF Nuclear export mediator factor NEMF Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] KDKEKENTLHIDTHQNTSKSI;STIDLRAILA;TSIQKARKVYWF 3 4.1 1.0026 -0.79914 7.86233 7.19554 0 0 3.54918 9.93764 6.99107 0 0 0 0 0 0 0 0 A0A8C0QB57 A0A8C0QB57_CANLF NKAP domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) ADSSSEFSEETGTSST 1 6.1 0.96182 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 4.17393 0 5.51595 A0A8C0QB71 A0A8C0QB71_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) NEDD4L Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of potassium ion transmembrane transport [GO:1901380]; protein polyubiquitination [GO:0000209]; regulation of dendrite morphogenesis [GO:0048814] cytoplasm [GO:0005737] sodium channel inhibitor activity [GO:0019871]; ubiquitin protein ligase activity [GO:0061630] ERGRPDTPPRGRRGAPEAR;FNRLDLPPYE;PGWEMRIAPNGRPFFIDHNT;SEIMVTNENKREYIDLVIQWRF 4 5.8 0.9866 -0.23303 10.46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QB78 A0A8C0QB78_CANLF DnaJ homolog subfamily C member 16 (Endoplasmic reticulum DNA J domain-containing protein 8) DNAJC16 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] endoplasmic reticulum membrane [GO:0005789] AAPIPNQYDKHF;AWSTRRRRVARVKIDPRRRRPRPV;FHENFYFDES;IPNQYDKHFMERDYTGY;KRQYNVNVYAP;NKNYIRFLSGWQQEN;WLWRGREMEV 7 10.6 1.0033 -0.83595 9.22916 0 0 0 6.75181 0 0 0 0 10.9929 0 0 8.98168 9.95593 8.4219 A0A8C0QB85 A0A8C0QB85_CANLF NELL2-interacting cell ontogeny regulator 1 C3H4orf48 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] extracellular space [GO:0005615] AYSLDSRTETLLLQAE 1 12.7 0.99039 -0.21021 0 0 0 0 0 0 10.138 0 0 0 0 0 0 0 0 A0A8C0QB92 A0A8C0QB92_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8B1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FYDHYLIEQIHSGKESEVRQFFFL;LSPGCDHS;RLLLVHGR;SSEPNSLCYVETAELD;SSSEPNSLCYVET;TDPEAPQAVESRRAVEA 6 6 1.0022 -1.2402 0 0 6.71905 10.2086 0 0 0 0 10.4623 0 0 0 0 0 7.7488 A0A8C0QB94 A0A8C0QB94_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) DKHSMFSFMWGI;WWEWELVQPLWKTVWRFLKELKIY 2 4.9 0.98866 -0.20304 0 0 0 0 0 0 0 10.6138 0 0 6.48562 0 0 0 0 A0A8C0QB97 A0A8C0QB97_CANLF Ras protein specific guanine nucleotide releasing factor 2 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] AAWTSDISQCVDNIRCNG;DIKKIKKVQ;LTDLAFIE;LVSLGGMKYIDADSE;QITLLDHII;SETIMFLHEIF;SGRPAGMYLLE;VERGKLSKVR;YRIFTTAAVVLAKLSDIYKR 9 8.8 1.0015 -0.69935 0 0 7.63147 9.51956 9.15386 9.42244 0 0 6.74967 0 0 0 0 9.66448 0 A0A8C0QB98 A0A8C0QB98_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF152 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; protein polyubiquitination [GO:0000209] lysosomal membrane [GO:0005765] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] RRPKLLDCKH 1 4.9 0.99084 -0.27478 0 0 0 0 0 0 12.3457 0 0 0 0 0 0 0 0 A0A8C0QB99 A0A8C0QB99_CANLF Matrix metallopeptidase 28 MMP28 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macrophage chemotaxis [GO:0010760]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AFLEKYGYLNEQ;KEVNGALPRPDGSI;LLRALWLLLWG 3 7.1 0.98766 -0.4976 0 0 0 0 0 0 0 0 10.4601 8.81881 0 0 0 0 0 A0A8C0QBA5 A0A8C0QBA5_CANLF Ubiquitin protein ligase E3 component n-recognin 5 UBR5 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ASSRIGHLLPEEQVYL;DMLLGRWRLSLELFGRVFM;EDDSQSNDSSDSDSSSSQSDDIEQ;EEDHHDEQEEH;EKVNEEQWSLREVVF;ELGKPDNNDGSK;FFRRSDSMTFLGCIPPNPFEVP;GERLYPRVQ;IDNEDSEHENDDDT;LIQQTMRQLNNHFGRRC;QENKDPLSA;RFLRSVARVFV;SLRARVDEAMEL;TPMAVHRV;TSFNDESGEN;VEGVAGEEDHHDEQ;VGGSGGGSSGRSSAGARD;WNWMNSARRERMTAREE 18 9 0.99718 -3.7229 0 10.54 6.80142 6.40795 0 10.0077 9.16151 0 11.3691 0 0 0 8.45857 0 8.83226 A0A8C0QBB1 A0A8C0QBB1_CANLF MET transcriptional regulator MACC1 MACC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] IFFREIETGNSF 1 1.5 0.95319 0.05044 0 0 0 0 0 0 0 0 6.8296 0 0 8.29471 0 0 0 A0A8C0QBD0 A0A8C0QBD0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740]; zinc ion binding [GO:0008270] ASKGCQLG;IITQLEDSCRVTKENS;IQSLDEPG;NMDYFTLDLEHIANTLR;TGKGGGGA;TPGSQAGSSLIQDGNPMENLEK;VARLPLVPFASL 7 22 0.99052 -0.26592 11.599 0 0 0 0 0 0 9.18123 0 0 0 9.6954 0 0 0 A0A8C0QBF9 A0A8C0QBF9_CANLF Sperm associated antigen 6 SPAG6 Canis lupus familiaris (Dog) (Canis familiaris) DTLVICLEDFD;EDHIKAAAAWALGQIGRH;GQFSKILFPW;HNAELSQAVVDAGAVPL;QTVVDVGAIAHLAQMILNPD 5 16.6 0.98492 -0.2405 3.73314 0 12.3847 8.66608 0 0 0 0 0 0 0 0 12.9066 13.051 0 A0A8C0QBG9 A0A8C0QBG9_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GQTLLEAAESH;KLLLPVPLLKVL;LESLSPKLLLPVPLLKVL;LQVLEEGLLAPQ;LSPKLLLPVPLLK;QTLLEAAESH;SPKLLLPVPLLKVL;TVHLVVEFF 8 14.4 0 2.1847 0 0 7.9582 0 6.33299 4.99521 10.3835 10.412 7.38284 10.879 10.0505 0 0 4.85718 10.1084 A0A8C0QBH1 A0A8C0QBH1_CANLF N-terminal asparagine amidase NTAN1 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; memory [GO:0007613] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein-N-terminal asparagine amidohydrolase activity [GO:0008418] GGGGGGGA;GGGGGGGG;PGGGGGGG;TPKPTLRPGWL 4 5.4 0.98594 -0.24596 8.79354 0 0 0 0 0 12.3457 0 0 0 0 0 0 0 0 A0A8C0QBI0 A0A8C0QBI0_CANLF LRRC8 pannexin-like TM region domain-containing protein LRRC8B Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] DIIYRVYLKQIIVKVILFVL;EQKDIIYRVYLKQIIVKVILFVLI;IVKVILFVLIITYVPYFLT;RASANMSSDP 4 5.8 0.99378 -0.17568 0 0 0 0 0 0 0 0 6.81365 0 3.27314 0 5.35322 0 0 A0A8C0QBI1 A0A8C0QBI1_CANLF Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) RAPGEF2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; small GTPase-mediated signal transduction [GO:0007264] anchoring junction [GO:0070161]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DSEDDDDEEDIE;HCRECKNFNS;NMDLPVDYMDENEEYFQ;YPDGKAEILCMGNS 4 3.4 0.98278 0.046227 0 7.75154 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QBJ1 A0A8C0QBJ1_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] DAGSEAESSG;ETGEAVQGS;VEVHRPDSEPDVNEV 3 5.1 1.0028 -0.72991 0 0 0 0 0 0 0 0 0 9.76765 0 0 0 4.32769 0 A0A8C0QBJ2 A0A8C0QBJ2_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEERFPRLR;LQVTDINDNPPVFPQNSY;NDNTPQFQLE;RYVVPEETEK;VIVLLALRLRRWHASRLL 5 8.1 1.0037 -0.82976 0 0 6.78842 8.70044 0 0 0 0 0 6.16475 0 0 0 0 0 A0A8C0QBK1 A0A8C0QBK1_CANLF Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) CCDC61 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737] DAATLAMDQPAGLQVDYVF;DQWRGEFDASFIED;THKTGNFKQF 3 8.9 0.99219 -0.19195 0 0 0 0 0 0 0 0 0 0 0 0 11.156 7.24527 0 A0A8C0QBK7 A0A8C0QBK7_CANLF Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) MINDY4 Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] ELITRYFL;LDHFGNPPNNF;PGSPRHLSC 3 3.6 1.0035 -1.5995 0 0 0 0 0 0 11.7661 0 8.57554 0 0 0 0 0 0 A0A8C0QBL0 A0A8C0QBL0_CANLF DH domain-containing protein ARHGEF1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] cytoplasm [GO:0005737]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EVHSLFLDRLMK;LDELIEVHSL;STEDLQNIFPS;VTLSHSPG 4 3.5 0.9948 -0.018653 0 7.60095 0 0 0 0 4.69443 0 0 0 10.4783 0 11.5098 0 0 A0A8C0QBL1 A0A8C0QBL1_CANLF UTP3 small subunit processome component UTP3 Canis lupus familiaris (Dog) (Canis familiaris) DGNEDGLEL;EDDEDGDSAGE;EDGLELPP;GEEEDDEDDG;GEEEDDEDDGGSSVQS;GGSRRRGAAK 6 9.7 1.0012 -2.6984 0 0 9.43927 8.2751 0 9.8008 0 6.07378 0 8.41591 8.07836 0 0 0 0 A0A8C0QBL7 A0A8C0QBL7_CANLF HMG box domain-containing protein HMGXB4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] GHGEKKKK;VPHTGAAA 2 2.7 1.0026 -0.77786 11.932 0 0 11.407 0 0 11.9241 0 0 0 0 11.7178 0 0 0 A0A8C0QBM4 A0A8C0QBM4_CANLF Fibrinogen C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] extracellular region [GO:0005576] DHDNYEGNCAEED 1 4.4 0.94338 0.059561 0 0 0 0 0 0 0 0 0 0 0 2.76804 0 0 0 A0A8C0QBM5 A0A8C0QBM5_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) GWGRRKENVYVSL 1 8.7 0.94237 0.059626 0 0 0 0 7.14608 0 0 0 0 0 0 0 0 0 0 A0A8C0QBQ7 A0A8C0QBQ7_CANLF Protein phosphatase 4 regulatory subunit 2 PPP4R2 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase 4 complex [GO:0030289] protein phosphatase regulator activity [GO:0019888] CTEEDEEEEEEEEEESFMTS;EEESFMTSREMIPER;HCTEEDEEEEEEEEEE;RQHCTEEDEEEEEEEEE;SEGSENTGPVSSGSDCH;TSREMIPERKNQEKES 6 15.1 0.81221 0.20627 0 0 6.27847 3.7241 5.06729 0 9.71153 7.21568 0 0 0 0 4.30531 0 7.08884 A0A8C0QBR2 A0A8C0QBR2_CANLF Roc domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] GTP binding [GO:0005525] GVAEIICPKN;HVIRLLLKPHIQAQQ;LDVDHNQL;RRRRRPRRAPRA 4 4 1.0021 -1.3917 0 0 0 0 0 0 0 0 0 0 0 4.23028 0 9.86756 0 A0A8C0QBR5 A0A8C0QBR5_CANLF Non-selective voltage-gated ion channel VDAC1 (Voltage-dependent anion-selective channel protein 1) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] GGRGRGRGDRAPAWAVSGAGPGAG;KTGYKREHINL;SNTRFGIAAKYQ;VNLAWTAGNSNT;YADLGKSARD 5 10.8 1.0039 -1.0757 0 0 0 0 0 0 0 0 8.88365 11.8087 0 0 0 4.96084 0 A0A8C0QBR9 A0A8C0QBR9_CANLF MARVEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATKVEDVFVGADSAR;CGAGGGQH;HLPPATCH;VGERGGPSA 4 10.5 1.0031 -2.4079 7.64739 0 0 0 0 10.5771 7.57524 4.28659 0 0 0 0 0 0 0 A0A8C0QBS3 A0A8C0QBS3_CANLF ATP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (NAD(P)HX dehydratase) Canis lupus familiaris (Dog) (Canis familiaris) metabolite repair [GO:0110051] ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453] SNTESLWRAQ 1 3.4 0.99899 -0.61146 0 0 0 0 0 0 0 0 0 9.52818 0 0 0 0 0 A0A8C0QBS9 A0A8C0QBS9_CANLF Membrane associated ring-CH-type finger 1 MARCHF1 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765] zinc ion binding [GO:0008270] GKKSVKQRPRRRRRASERYEHA;HVIAITCVVWSLY 2 6.6 0.97319 0.046699 0 0 0 0 0 0 6.68748 0 0 0 0 0 0 0 0 A0A8C0QBT0 A0A8C0QBT0_CANLF Cyclin G associated kinase GAK Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583] clathrin-coated vesicle [GO:0030136] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ALVEEEITRNTT;APASFPSTHSAPPPA;ASCGCGCGG;DIQEKYPDLFQVN;HTVLWDGESRWAPVGMA;LDWHEEKDTETSP;PAATRATSWG;SVANYAKGDLDISYITS 8 7.4 1.0022 -1.2277 5.842 10.3608 0 0 0 5.8893 0 0 7.91265 0 0 0 7.84631 9.97871 12.9167 A0A8C0QBU5 A0A8C0QBU5_CANLF "Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (Mitochondrial sulfonylurea-receptor)" ABCB8 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transport [GO:0006813] membrane [GO:0016020]; mitochondrion [GO:0005739] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DSESERVVQEALDR;ILDEATSALDSESERVVQEAL;PCPRQAATTRLLPDILGRQ;VGERGATLSGGQ;VNVQIPLLLGQLVEIVAKYTRDH;VRAFAMENREE 6 14.1 0.98758 -0.34875 0 9.67812 0 0 8.28351 4.13529 0 0 3.6663 0 0 8.73698 7.88838 7.75449 0 A0A8C0QBX0 A0A8C0QBX0_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] RNA binding [GO:0003723] EDNEIVFKQ;FKKKEKLLRKKLAKKGI;KKKKKKKK;LPKKKKKKKKSSR;PKKKKKKKKSSRTTT;VLPKKKKKKKK;VLPKKKKKKKKS;VLPKKKKKKKKSS;VLPKKKKKKKKSSR 9 14.5 0.95711 0.050946 12.1141 4.50976 0 6.03091 5.94362 0 0 12.9487 10.078 5.31314 0 4.13323 0 5.50453 0 A0A8C0QBY3 A0A8C0QBY3_CANLF Protein SHQ1 homolog Canis lupus familiaris (Dog) (Canis familiaris) box H/ACA snoRNP assembly [GO:0000493] EEKYQLRKFV;FRFYAKPYFL;LLAYCYET;PAAERRQKRLAAE;SEERVEEEDEEFDW;SEERVEEEDEEFDWEIEQSPYE;TDTYTEMM 7 12.7 1.0033 -1.5753 11.0221 11.3233 0 12.7788 13.1243 13.1223 8.07543 0 0 0 0 0 11.7305 0 0 A0A8C0QBZ4 A0A8C0QBZ4_CANLF Regulating synaptic membrane exocytosis 2 RIMS2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] membrane [GO:0016020] small GTPase binding [GO:0031267] DDEDVDSRDEYERQRREEEYQARY;EPHWYKLQTHDVSSLP;GVCIAKKKTKVARKTL;LVDPTLAPLTRRASQ;QIIEHHHRDGRSHPR;RMDHKSFMG;RQMKINKYKQVAGS 7 8 0.9414 0.064183 0 0 0 0 0 0 10.6824 0 0 0 0 0 0 0 0 A0A8C0QBZ7 A0A8C0QBZ7_CANLF Dihydrofolate reductase (EC 1.5.1.3) Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; response to methotrexate [GO:0031427]; tetrahydrofolate biosynthetic process [GO:0046654] dihydrofolate reductase activity [GO:0004146]; NADP binding [GO:0050661] DLPWAPLRNEFKY;FKYFQRMTTNSSVEGK 2 15 0.98982 -0.21276 0 0 0 8.74204 0 0 0 0 0 0 0 0 0 5.54782 0 A0A8C0QC04 A0A8C0QC04_CANLF CRAL-TRIO domain-containing protein ATCAY Canis lupus familiaris (Dog) (Canis familiaris) EHRIDLHMIRPYMRVVTHGGYYGE;FLYVISSL;GPPSGFISAASQ;LELLVAEDYMIVYL 4 12.4 1.0031 -1.4961 0 9.9884 0 0 0 0 0 0 0 6.67299 0 0 0 9.61717 11.7825 A0A8C0QC12 A0A8C0QC12_CANLF SH3 domain-containing protein SH3TC2 Canis lupus familiaris (Dog) (Canis familiaris) ALENEHQEVCALF;GAVPLARRMKAMRTEL;IQSQKAQFLITFKTMEEI;QEAARRRLWALENEHQEVCALF;RLATVYYSLRMYEMAEDCYLKTLSL;VRNQAVTLANLGH 6 7.4 1.0021 -0.68 8.94997 0 6.97384 0 0 10.7458 0 9.36137 0 0 0 6.01436 0 0 0 A0A8C0QC21 A0A8C0QC21_CANLF Connector enhancer of kinase suppressor of Ras 1 Canis lupus familiaris (Dog) (Canis familiaris) AGATLVLKKV;DLTSNPRPGPS;LSSDPREQ;SLLTSDPGQYS;WRRCWFVLKRHTLYWY 5 8.2 0.98876 -0.26234 8.71466 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QC23 A0A8C0QC23_CANLF Apolipoprotein L6 APOL6 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576] lipid binding [GO:0008289] REEALGHW;VVEHLQNQDIQA 2 5.9 1.0019 -1.3659 11.7866 8.411 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QC25 A0A8C0QC25_CANLF "Nuclear transcription factor, X-box binding 1" NFX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EMQSRPPPPIPHHR;QPWQKLRSEKQHIKVK 2 3 0.91609 0.11018 0 0 0 0 0 7.88862 0 0 10.4108 0 0 0 0 0 0 A0A8C0QC40 A0A8C0QC40_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EANADDFVHIYSEGN;FYLWCTLH;LSFILPKEYTHRF;MDAFVANYNFLDT;PLPLHAGHIYLKIATKII;PTSLVAGIQIKHLHKVFEFG;SVVFLDEPSTGLDP;VFLDEPSTGLDPV;WNTITWMCRSK 9 7.2 1.0019 -0.67277 0 8.26308 7.39703 0 0 7.38888 9.35341 9.11385 11.4317 2.57848 0 8.98142 0 0 6.40378 A0A8C0QC67 A0A8C0QC67_CANLF SSD domain-containing protein PTCH1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of smoothened signaling pathway [GO:0045879] plasma membrane [GO:0005886] hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; smoothened binding [GO:0005119] AVLALEHMF;CRPTPLPAQA;EAMFNPQLMIQTPKEE;ENKQLPKMWLHYFRDWLQGLQD;LLKPKAKVVVIFLFLGLLGV;TQKVLSFTTTTLDD;VEVVHQSVAP;YKSGELITETGYMDQI 8 7.9 1.0028 -2.1185 0 11.3106 10.8407 0 10.8007 9.96292 5.33921 0 7.43704 0 0 0 9.35584 0 0 A0A8C0QC75 A0A8C0QC75_CANLF Nucleoplasmin core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; single fertilization [GO:0007338] nucleus [GO:0005634] ERRIPRRRRKRRRKVTV;QQQQQRCREGAAA;RIPRRRRKRRRK 3 15.7 0.85211 0.16696 0 0 0 0 0 7.24241 0 0 0 9.34467 0 0 0 0 6.41545 A0A8C0QC92 A0A8C0QC92_CANLF dipeptidyl-peptidase IV (EC 3.4.14.5) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] LRILYEEVDESEVE 1 2.7 0.94373 0.086581 0 0 0 0 0 0 0 0 0 0 0 0 10.2357 0 0 A0A8C0QC99 A0A8C0QC99_CANLF Transmembrane protein 145 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] membrane [GO:0016020] LLLLLLPL;LSVYMTLYLT;PPLLLLLL;RAPALRRLLPPLLLLLLPLPP;RAPALRRLLPPLLLLLLPLPPRAR;RRLLPPLLLLLL 6 6.9 0.98824 -0.47255 0 0 5.63564 0 0 0 0 0 0 0 10.7586 0 0 9.70714 4.18682 A0A8C0QCA7 A0A8C0QCA7_CANLF Protein Wnt WNT16 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] DVAGRRAVRGP;RSRREGREGAGQGP 2 4.3 0.98069 0.035491 0 0 0 6.52066 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QCA8 A0A8C0QCA8_CANLF Radial spoke head component 4A RSPH4A Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294] radial spoke [GO:0001534] DEDEEDDDQ;EDEEKEEKGEEPDYI;EEMEETEEDEDEEDDDQ;MEETEEDEDEE;RTSTPLDDLTGPDASSAPS;SVEEEQAFRAAQEA;VEFREGEDEEDIEDEDVPEERDD 7 12.2 1.0021 -0.71237 5.46339 0 10.455 0 0 5.24089 0 0 6.403 9.29614 0 3.5008 5.66403 0 0 A0A8C0QCE7 A0A8C0QCE7_CANLF Amino acid transporter transmembrane domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVGRRLFVIKRRK;IVQNIPDPSH;LANITMLVS;NFKQVIEAANG;TALYISLG;VGRRLFVIKRR;VGRRLFVIKRRK;VGRRLFVIKRRKA;VGRRLFVIKRRKAERIW 9 10.1 1.0022 -1.4474 3.53381 7.08044 5.4648 0 4.20218 3.8744 0 0 3.10027 0 0 0 10.1618 6.99164 0 A0A8C0QCE9 A0A8C0QCE9_CANLF Myelin regulatory factor MYRF Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKNSPSLSLHGRTRRGA;GIGHSKHPKSSEPLASPA;HFQVTVYIGMLGE;LVHYRYKPEF;SGPPIKAEPKAPYAPG;WRAHPGESCGAE;YPVLQRDLYMKAEP 7 8.2 0.99286 -0.28341 0 0 0 0 11.3245 0 0 0 0 0 0 0 0 0 0 A0A8C0QCF5 A0A8C0QCF5_CANLF Zinc finger CCCH-type containing 12A ZC3H12A Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] DLRPVVIDGSNVAMRPAL;FSVPADYAP;GPVGGGHFSVPADYAPPPAT;IDGSNVAMRPALV;LQGERQEWKRFIEER;PGSVPTEPEP 6 9.9 1.0036 -1.6069 8.54466 0 0 0 7.77722 0 0 0 0 0 0 0 10.3271 2.35055 8.82171 A0A8C0QCF9 A0A8C0QCF9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DAKILNKILATRIQKYIKK;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;SLFFERIN 6 5.7 0.98756 -0.46177 0 0 0 5.48617 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QCG8 A0A8C0QCG8_CANLF SUMO-activating enzyme subunit 2 (EC 2.3.2.-) UBA2 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; SUMO activating enzyme complex [GO:0031510] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; SUMO activating enzyme activity [GO:0019948] VHLAEKGDGAELI 1 2.4 0.98631 -0.25969 0 0 0 0 0 0 0 0 10.9827 0 0 0 0 0 0 A0A8C0QCI4 A0A8C0QCI4_CANLF Small ribosomal subunit protein uS5 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EFIDHLVKTYTRVSV;VISQTYSYLTPDL 2 35.4 0.98451 -0.24348 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.8508 A0A8C0QCL3 A0A8C0QCL3_CANLF "ATP synthase-coupling factor 6, mitochondrial (ATP synthase peripheral stalk subunit F6)" LOC100682783 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] GGPVDTGP;VSVLLRRNI 2 16.8 1.002 -1.436 0 0 0 0 0 0 8.87264 0 0 0 0 0 0 0 0 A0A8C0QCM5 A0A8C0QCM5_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AEAYRLKFAFADA;LDGIQDNYTFAQP;NVEADTYWC;RHLDQHEVRYLQFAF;VLHPWTSIQHVYGAQHPPFDPL 5 13 1.0005 -0.93018 0 8.18031 0 6.28871 0 0 7.78287 0 0 0 0 5.587 0 0 0 A0A8C0QCQ1 A0A8C0QCQ1_CANLF RRM domain-containing protein RBMXL2 Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" spliceosomal complex [GO:0005681] RNA binding [GO:0003723] GGGGGGGG;GYSPRDGYLSRDYP;LEAAFGKYG 3 8.2 1.0016 -0.74327 0 8.98925 8.58395 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QCW2 A0A8C0QCW2_CANLF Probable N-acetyltransferase 14 NAT14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] N-acetyltransferase activity [GO:0008080] ARVTRLSVSRWHRRR;GVAGMLEG 2 11.2 1.005 -1.0505 10.8743 0 0 0 0 0 0 0 0 0 0 0 0 8.13627 0 A0A8C0QCX4 A0A8C0QCX4_CANLF SEL1L2 adaptor subunit of ERAD E3 ligase SEL1L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFIGKMYLEG;ATHYSIAADKYHSAQA;AVGKKKIQRKL;DLFVIGLIIVVLIFL;IVVLIFLLRNRYG;NEIKQFLSHILERRKLIKVI;VGKKKIQRKLR;VGKKKIQRKLRIKGIQNK;VGKKKIQRKLRIKGIQNKDLSK;VGKKKIQRKLRIKGIQNKDLSKRN 10 13.4 0.99399 -0.11814 0 0 3.83744 0 6.57503 0 0 0 5.01547 0 0 4.6332 9.73249 10.1486 8.90379 A0A8C0QCZ8 A0A8C0QCZ8_CANLF ENTH domain-containing protein EPN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] LMDLADVFTAPA;SPLGGGPG 2 3.7 0.98623 -0.39016 15.7945 0 15.7442 0 0 7.10643 0 0 0 0 0 0 0 0 0 A0A8C0QCZ9 A0A8C0QCZ9_CANLF CFA20 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ESEDDFYGSDSSEEEYDW;LPRENKQILGLIQRFLVLQIYIPL;LYDPCLNCYFDPQ;TESEDDFYGSDSSEEEYDW 4 8.5 0.99472 -0.12655 0 7.15775 0 0 0 0 0 9.34972 0 0 8.22028 0 0 0 11.4945 A0A8C0QD10 A0A8C0QD10_CANLF Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) PIK3C3 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; endocytosis [GO:0006897]; phosphatidylinositol-mediated signaling [GO:0048015] "endosome [GO:0005768]; peroxisome [GO:0005777]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524] TSYKAFSTRWNMF;VELIPLPL 2 2.5 0.94023 0.062205 0 0 8.58466 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QD20 A0A8C0QD20_CANLF Actin filament-associated protein 1-like 1 AFAP1L1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102] DPMSSSYESYDEEEEEG;DQWPEPRVYDDV;EQAEEWLKRLSQ;LSLLDHEY;NDSDPMSSSYESYDEEEEEG;PTDGCSPAHSIMDGYYEDADS;TALEKKMAVASI;VETLTSIV 8 12.5 1.002 -1.2835 12.9384 8.95858 13.2284 0 0 0 0 8.67356 10.4993 13.2683 0 7.70556 0 4.59759 8.19992 A0A8C0QD35 A0A8C0QD35_CANLF Beta-glucuronidase (EC 3.2.1.31) GUSB Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] lysosome [GO:0005764] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ESKVVAQGT;HLWWPYLMHEHPAYLYSLEVRLTA;SAAKSQCL;VYLLDEESKVVAQ 4 7.4 1.0034 -1.6227 0 0 0 0 9.56419 0 10.1214 0 0 0 0 0 0 0 0 A0A8C0QD37 A0A8C0QD37_CANLF Splicing factor YJU2 YJU2 Canis lupus familiaris (Dog) (Canis familiaris) generation of catalytic spliceosome for first transesterification step [GO:0000349] U2-type catalytic step 1 spliceosome [GO:0071006] metal ion binding [GO:0046872] EEARKRRLLEDSDSEE;WGNREDFQAALPQRSRTQL 2 9.4 0.93478 0.099114 0 0 0 8.37786 0 0 0 0 0 0 0 0 7.99498 0 0 A0A8C0QD60 A0A8C0QD60_CANLF Mitofusin 2 MFN2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LTQEELMVSMV 1 1.5 0.9842 -0.2473 0 0 0 0 0 0 0 0 10.4426 0 0 0 0 0 0 A0A8C0QDA9 A0A8C0QDA9_CANLF Thymosin beta TMSB10 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin monomer binding [GO:0003785] ADKPDMGEIASFD;TLPTKETIEQE;TLPTKETIEQEKRSEIS 3 68.2 0.9916 -0.29993 0 0 0 0 0 8.81009 9.37171 0 0 10.9103 0 8.71702 0 0 0 A0A8C0QDB0 A0A8C0QDB0_CANLF Corticotropin releasing hormone receptor 2 CRHR2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AALVAAFLLF;ARGSGARWTRRCCT;GAPGWGAL;WGALQGLVGARGAGAQSRPLAA 4 8.2 0.99714 -0.59558 11.2189 11.4809 0 11.676 7.06673 0 0 8.57811 10.2291 0 0 0 11.2877 0 0 A0A8C0QDD0 A0A8C0QDD0_CANLF Myelin transcription factor 1 MYT1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ARTRSKAVRV;EDAPHAPTQKAP;EDAPHAPTQKAPELRHPASP;EDEEEEEEEEEEEEEEE;EEEEEEDEEEEEEEEEEEEEEEEV;EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEEEEEE;KSHFASKPIGSSAGP;LNGSPFSWKSL;TSSSSAGFDYAHD 10 10.1 0.99345 -0.28364 9.74505 0 9.51793 0 0 0 0 8.15142 0 6.01627 0 0 0 0 11.5339 A0A8C0QDF8 A0A8C0QDF8_CANLF Nicotinamide N-methyltransferase Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] EIIATDYTDQNLQELQ 1 6.1 0.99101 -0.22087 0 0 0 0 0 0 0 0 0 0 0 0 9.61756 0 0 A0A8C0QDG5 A0A8C0QDG5_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) PPPPPISDAATAHLDPCSP;VLGRRSAP 2 6.3 1.0027 -1.3525 0 0 0 0 0 5.52554 10.6659 0 0 0 0 0 0 0 0 A0A8C0QDG8 A0A8C0QDG8_CANLF HEAT repeat-containing protein 6 HEATR6 Canis lupus familiaris (Dog) (Canis familiaris) ENYSEGGGVAPEDVST;FDQLISENYSEGGGV 2 2.1 0.99323 -0.064374 0 0 0 0 0 9.64147 0 0 0 0 0 0 0 6.20261 0 A0A8C0QDH5 A0A8C0QDH5_CANLF Rho GTPase activating protein 26 ARHGAP26 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020] GTPase activator activity [GO:0005096] DICAEWEIKTITSA;LFTFYHHGYELAKDFSDFKTE;SELSFTAGTVFDNETEREKVDTHA;VESLMKKMKENPLEHKTISPYTME 4 11.2 0.97371 0.041303 0 0 0 0 6.08583 0 0 0 0 0 0 0 0 0 0 A0A8C0QDH9 A0A8C0QDH9_CANLF Actin-associated protein FAM107A FAM107A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; stress fiber [GO:0001725] ELIKPKKLLNPVKASRS;FEQELLRRQQRLNQL;IKVRENLRRITTI;ITTITSEERAL 4 36.1 0.99383 -0.075314 3.73671 0 0 0 0 0 11.6885 6.40919 0 6.24035 0 0 0 0 0 A0A8C0QDJ0 A0A8C0QDJ0_CANLF Heparan sulfate 2-O-sulfotransferase 1 HS2ST1 Canis lupus familiaris (Dog) (Canis familiaris) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]" membrane [GO:0016020] heparan sulfate 2-O-sulfotransferase activity [GO:0004394] ALDEEEDM;LWLQIPFFCGHSSECW 2 7.3 0.99479 -0.563 0 0 0 0 0 0 0 0 0 0 0 0 10.7346 0 0 A0A8C0QDJ8 A0A8C0QDJ8_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KPHRRPCMPITLPM 1 2.5 0.93646 0.060951 0 0 8.05355 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QDM0 A0A8C0QDM0_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DVKPFKCPRCERDFNAPALLE;EAASGSGR;GCGHCGAL;LHHQVVHTGEKPYCCL;QGPGGPPVQAWASGA 5 13.5 1.0014 -2.6545 0 0 0 10.1724 9.00815 8.49349 8.33494 0 0 8.55846 9.86 0 10.1596 0 0 A0A8C0QDM1 A0A8C0QDM1_CANLF Neurochondrin NCDN Canis lupus familiaris (Dog) (Canis familiaris) ALLLVTKAVKA;CFCSDPEL;TASHYRMAALEQC 3 4.5 1.0027 -0.79868 0 0 0 0 0 0 0 10.6269 0 0 0 0 0 9.75609 0 A0A8C0QDM8 A0A8C0QDM8_CANLF C2H2-type domain-containing protein ZNF827 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] ANGRVESPVNVGSN;CHTVPTGGLKGSADAAGESISQ;EGELSEGEHWY;EVLRDSLQCQDHLSPGVSSLCE;LLLPVPKG;NAADRPANHTKL;NSASEEESG;PQSLELLLLPVPKG;PSNSASEEE;SWKFNDQLFP 10 10.3 1.0019 -1.4315 8.50311 0 0 11.7745 9.92806 12.4987 9.87129 10.0637 10.0109 9.13812 8.56083 9.4661 7.1639 10.7196 0 A0A8C0QDQ1 A0A8C0QDQ1_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) DTX2 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DVTHSKTI;MASDEDCIICME;TASGASAS;VLELLKVAWKRRLIFTV 4 8.7 0.9818 0.046227 0 2.72417 0 0 0 0 4.25081 0 0 0 0 4.02361 0 0 0 A0A8C0QDR9 A0A8C0QDR9_CANLF NOP14 nucleolar protein NOP14 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730]; small-subunit processome [GO:0032040] AAHFGGGG;DSDTETEEDCGRPDTEPRLAPQK;FLARMQLSETLERDAE;NEDEELTHYGQSLADI;SEEDHHEDPSDENLEESSDPDGHSD;YKERDKSNVFTDKRFGEYS 6 12.5 1.0033 -0.87458 0 0 0 9.73978 10.8462 0 6.95884 0 0 0 0 0 8.50791 0 9.99647 A0A8C0QDS8 A0A8C0QDS8_CANLF Aquaporin-1 (Aquaporin-CHIP) (Water channel protein for red blood cells and kidney proximal tubule) AQP1 Canis lupus familiaris (Dog) (Canis familiaris) hyperosmotic response [GO:0006972]; renal water transport [GO:0003097] plasma membrane [GO:0005886] ammonium channel activity [GO:0008519]; carbon dioxide transmembrane transporter activity [GO:0035379]; glycerol transmembrane transporter activity [GO:0015168]; water channel activity [GO:0015250] GGGRRGPE;LSGGTWFLSPQ;RTDDHDADQPTEANVPCWT 3 7.8 0.98942 -0.1978 0 8.3407 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QDS9 A0A8C0QDS9_CANLF "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3" ST8SIA3 Canis lupus familiaris (Dog) (Canis familiaris) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" FFFHTSATVT;HYYDKKGTKFTTKWQESHQLPAEFQ;PDVSPIVNKHFNI 3 13.4 0.99264 -0.55189 0 0 0 0 0 0 0 0 0 0 6.95629 0 0 0 0 A0A8C0QDT0 A0A8C0QDT0_CANLF "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3)" Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] GVASDRTGLPS;HYYDKSWKRTIFYTNHDFPLERTL;PDSWECLIFPAR 3 6 0.99086 -0.19504 6.92861 0 0 8.43996 0 0 0 9.60292 0 0 0 0 0 0 0 A0A8C0QDU0 A0A8C0QDU0_CANLF U2 snRNP associated SURP domain containing U2SURP Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] DGIPIDATPIDD;LKQIQEERDER;LLALIHRMIEFVVRE;NATYRTIQGHLQSENFKQRVMTC;SEEEENQNQEEESED 5 7.8 0.98545 -0.43195 0 0 6.42714 0 0 0 0 0 0 0 7.78424 0 0 0 8.51124 A0A8C0QDU1 A0A8C0QDU1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] endomembrane system [GO:0012505]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] FADLPALFGLPLAP;HNVRSDELVRMAHVYE;LDEYEEGDQ;RAAPALGA 4 10 1.002 -0.95975 0 11.663 0 5.90533 0 7.30725 0 0 0 0 0 0 0 6.29418 0 A0A8C0QDU3 A0A8C0QDU3_CANLF Alpha-L-fucosidase (EC 3.2.1.51) FUCA2 Canis lupus familiaris (Dog) (Canis familiaris) fucose metabolic process [GO:0006004] alpha-L-fucosidase activity [GO:0004560] LAWLYNKSPVRDTVVTNDRWGY;LLLPLLLPPLLL 2 7.7 0.93553 0.097828 0 0 0 0 0 0 0 0 0 0 0 0 0 8.55892 0 A0A8C0QDV2 A0A8C0QDV2_CANLF Zinc finger and AT-hook domain containing ZFAT Canis lupus familiaris (Dog) (Canis familiaris) CPTDGCDYNTPDK;LGEEDGEAGATKIVPVE;LGRRVQLKGLIGKRAMK;LKNKHGLKLVENEGDPKWE;PETTTADLAPRR;QEYAIQQTPYEQ;TVVKQVTDEEPSSNHTVMIQETLQQ 7 9.8 0.9507 0.057668 9.76775 0 0 0 0 0 12.5808 7.65464 0 0 0 0 0 4.46813 0 A0A8C0QDV7 A0A8C0QDV7_CANLF Solute carrier family 3 member 1 PPM1B Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] GEGLILEYNTN;RFMGTEAYGESIDRTMMY;WMIGGPDNARLTSRFGE 3 6.9 0.98736 -0.40466 10.3427 0 0 0 0 0 0 0 0 0 10.3314 0 0 0 0 A0A8C0QDX3 A0A8C0QDX3_CANLF Podoplanin PDPN Canis lupus familiaris (Dog) (Canis familiaris) actin-mediated cell contraction [GO:0070252]; cell-cell adhesion [GO:0098609]; lung development [GO:0030324]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of platelet aggregation [GO:1901731]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of myofibroblast contraction [GO:1904328]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; response to hyperoxia [GO:0055093]; Rho protein signal transduction [GO:0007266] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; filopodium [GO:0030175]; lamellipodium [GO:0030027] chemokine binding [GO:0019956]; protein-folding chaperone binding [GO:0051087]; signaling receptor binding [GO:0005102] EDTETTVEKDGL;PSTVRPDDI;VGVLLAIGFIGGIIIV 3 23.1 1.0028 -0.86113 0 0 0 0 0 0 0 13.131 0 0 0 0 0 0 0 A0A8C0QDY8 A0A8C0QDY8_CANLF Matrix metalloproteinase-9 (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) MMP9 Canis lupus familiaris (Dog) (Canis familiaris) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] PTVCATGPPTTRPSERPTAGPT 1 3.3 0.98554 -0.25844 0 0 0 0 0 0 0 0 11.1364 0 0 0 0 0 0 A0A8C0QE00 A0A8C0QE00_CANLF Solute carrier family 14 member 2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] urea transmembrane transporter activity [GO:0015204] ANRIYYLSQ;FISSPLICLHAAIG;HALREMSHTHRSPL;ISSPLICLHAAIGST;LVAVFSEKLDYYWWLL;NNPVSGILIV;VFGKSEHQ 7 9.4 1.0033 -2.057 0 0 0 0 0 0 0 10.4063 0 13.9027 0 0 0 11.3684 9.91232 A0A8C0QE19 A0A8C0QE19_CANLF KIAA0319 like KIAA0319L Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] KMVFFVQNEPPNQ;RQIGVLLGVLDSDIIVQK 2 3.2 0.913 0.11052 0 0 0 0 0 0 7.91115 0 0 0 5.33807 0 0 0 0 A0A8C0QE20 A0A8C0QE20_CANLF Calpain 9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] APENFYEILEKA;PGEYILIPSTFEPHQEADFC 2 5.1 0.98928 -0.19782 0 0 0 0 0 0 7.39883 0 0 0 8.286 0 0 0 0 A0A8C0QE51 A0A8C0QE51_CANLF Secretory carrier-associated membrane protein (Secretory carrier membrane protein) SCAMP4 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] LSAGPAWPG;PATRHVRSSCY;TSTTASRCSVVSWRPSAA 3 6.4 0.98776 -0.22857 0 0 0 0 0 10.4068 0 0 9.73486 0 0 0 0 0 0 A0A8C0QE71 A0A8C0QE71_CANLF Retinol dehydrogenase 5 RDH5 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" NTLQECWARLPPSTQA 1 5 0.94381 0.086128 0 0 0 0 0 0 0 0 7.8141 0 0 0 0 0 0 A0A8C0QE74 A0A8C0QE74_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APGAAREQSQV;EEGLEAWTPGSE;LKRNLQKSKLRVSLP 3 4 0.9922 -0.19237 0 0 0 7.35209 0 0 0 0 0 0 0 0 4.97039 0 0 A0A8C0QE79 A0A8C0QE79_CANLF ER membrane protein complex subunit 3 (Transmembrane protein 111) Canis lupus familiaris (Dog) (Canis familiaris) protein folding in endoplasmic reticulum [GO:0034975] EMC complex [GO:0072546] ADQSQMMQEQMT 1 7.3 0.95361 0.05044 0 0 0 0 0 0 0 9.34379 0 0 0 0 0 0 0 A0A8C0QE92 A0A8C0QE92_CANLF Carbohydrate kinase PfkB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fructose metabolic process [GO:0006000] ketohexokinase activity [GO:0004454] LREFQWEPPQGRNASEQV 1 6 0.97311 0.048313 0 0 0 0 0 0 0 0 0 0 0 5.65487 0 0 0 A0A8C0QEA2 A0A8C0QEA2_CANLF Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (Phospholipid methyltransferase) (PLMT) PEMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; phosphatidylcholine biosynthetic process [GO:0006656] endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966] phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [GO:0080101]; phosphatidyl-N-methylethanolamine N-methyltransferase activity [GO:0000773]; phosphatidylethanolamine N-methyltransferase activity [GO:0004608] MLAPVAPGPSPPVVIP;SLGAAILLLNI 2 11.2 0.98534 -0.2367 0 0 0 0 0 0 0 0 7.17113 0 0 0 9.43661 0 0 A0A8C0QEA5 A0A8C0QEA5_CANLF Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated potassium channel activity [GO:0005249] HYSPFKAVWDWL;MAAPAGKA;SLLQHCKP;YTAVFTPYSAAFLLKETEEGPPAP 4 6.3 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 0 0 12.7764 0 0 0 A0A8C0QEB7 A0A8C0QEB7_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120] basolateral plasma membrane [GO:0016323]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] YSLMFHII 1 4.3 0.98237 -0.2498 0 11.5602 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QEC8 A0A8C0QEC8_CANLF Signal transducer and activator of transcription Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AALGNDDSKVNMLFFHFL;FSLDPHQMRQHQLLQ;FTAGAKLL;GVNLRKAQVLELLQRLLHR;LEPMLEPTLDMVPQG;LQPFTKEVLQSLPLTKIIR;LSWQFSSY;NWQEAALGN 8 13.2 1.0028 -1.5106 5.64478 0 0 0 0 15.0761 10.3078 8.71284 0 0 10.1157 10.2205 8.91865 0 0 A0A8C0QED1 A0A8C0QED1_CANLF Transmembrane and ubiquitin like domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] DAPPCDLH;SSGSGSCC 2 4.4 1.0019 -1.3703 0 0 0 4.92775 0 0 0 0 0 0 0 0 11.0094 10.9509 0 A0A8C0QED4 A0A8C0QED4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] EVQLVESG;EVQLVESGG;EVQLVESGGALVKPG;GASLRLSCVASGF;VASGFTFSSYDMSWVRQAPGKGL;VRQAPGKGLQ 6 43.4 0.99154 -0.0019771 0 0 0 0 0 0 0 8.8158 0 11.6469 11.6975 0 0 0 0 A0A8C0QED5 A0A8C0QED5_CANLF Trophoblast glycoprotein TPBG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CRDHMEGYHYRYEINADP;DCDPILPPSLQ;GAIFLLVLYLNRK;HLDLRNNSLVSLTY;LMLNHIVPPDD;LRLARLALVL;PPSLQTSYVFLGI 7 20.2 1.0024 -0.76912 10.3559 10.7345 10.5579 8.82553 6.84536 0 0 5.14106 10.3059 0 0 0 11.9698 11.0624 0 A0A8C0QEE4 A0A8C0QEE4_CANLF Secretogranin-1 (Chromogranin-B) SHLD1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; secretory granule [GO:0030141] ARYGTHSAST;DNMDDNFLEGEEENGLTLNE;DVDSGPAA;ESEEDTDP;LHYRKKSAEFPDFY;NWGYEKRNLSPK;RDPTDASDANRPSGR;VGSREESEESEEDTDP 8 11.9 0.99947 -2.874 6.82299 11.1193 9.98542 7.87621 0 7.75729 7.22815 0 4.25505 10.0954 8.02641 10.0429 9.35949 10.2037 0 A0A8C0QEG4 A0A8C0QEG4_CANLF DMRT like family A1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] AAPAAGAGG;DLANSGELE;DTRDLANSGELEN;LRGGPGAG 4 5.3 1.0021 -1.297 0 0 0 0 0 0 8.97997 11.6947 11.6744 0 0 0 0 0 0 A0A8C0QEH6 A0A8C0QEH6_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GALSWSSDLGSSIPA;LFFNTRLRGLSWS;PAGEEASFRGASP;PQDMKEQFLSEIQEVLKLTL;RTRQFPPPPRPSLCSSSS 5 14.2 0.9864 -0.38974 0 0 8.50593 0 0 0 0 0 9.8062 0 7.93233 0 0 8.20667 8.58459 A0A8C0QEI1 A0A8C0QEI1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] ETYGPFQIRIQ;LVRTWGPPAVL 2 4.6 0.98441 -0.24002 0 0 0 0 0 0 0 11.1228 0 0 0 0 0 0 0 A0A8C0QEK9 A0A8C0QEK9_CANLF Tektin-2 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement involved in cell motility [GO:0060294] cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815] IDVVKDPVEEEL;MRVPFPEGEVAPPPA 2 4.1 0.98908 -0.3023 0 0 0 0 0 0 0 0 9.39521 0 9.6566 0 0 0 0 A0A8C0QEL4 A0A8C0QEL4_CANLF E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) UBE3D Canis lupus familiaris (Dog) (Canis familiaris) ATLPPSLRYMNSFQVLPK;EGCTELQLPAEVRL 2 8.1 0.9848 -0.25477 0 0 0 0 0 0 0 10.5253 0 0 0 0 0 0 0 A0A8C0QEL6 A0A8C0QEL6_CANLF FYVE-type domain-containing protein WDFY2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] FIFFLRFYFHIY;ISCGGDGG;VTMILFVLELEWVLSTGQDK;WNFKQMWDSKKIG 4 12.2 1.0032 -1.5537 0 0 0 7.73796 0 7.74362 0 8.47703 6.12387 0 0 0 0 0 0 A0A8C0QEP9 A0A8C0QEP9_CANLF Sorting nexin 14 SNX14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" AGLYFLPCSGT;ESKLTEFHGTFPDAQLP;FCENTEPRSLQDKQKRAKQT;QELFPELNKVQKEVTSVTSWM;SVLIRRIHKVDIPSIITKK 5 8.5 0.9653 0.04865 0 0 0 0 0 0 0 0 0 0 0 0 10.1011 0 0 A0A8C0QEQ5 A0A8C0QEQ5_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] HCTVMVEVEDT;LNVEVDLSPKHLSD;QENALVSYSLVERR 3 4.7 0.9941 -0.15592 0 10.7212 10.9738 0 0 9.60844 0 0 0 0 0 0 0 0 0 A0A8C0QES3 A0A8C0QES3_CANLF Peptidase M14 carboxypeptidase A domain-containing protein CPA2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] NWDAGFGGPGASNNPCSDSYHG;QETWLALRTIMEHT;QTKNRMWRKTR;VLLDKENEEM 4 13.7 0.98619 -0.23201 0 0 0 0 0 0 0 0 12.9802 0 0 0 0 0 4.57791 A0A8C0QEU2 A0A8C0QEU2_CANLF Interleukin 1 receptor like 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787]; interleukin-1 receptor activity [GO:0004908] GAAVSVTY;GVSVALPS;KEGRFIRWGIKLSVS;LVTHDGVGSMEWL;SNVSAEDGGNYACQ;TDTRDNTNLRC;VGLVTHDGVGSMEWLTVG 7 12.7 1.002 -2.595 10.0598 0 0 0 0 10.2467 0 0 0 0 0 0 8.27812 0 0 A0A8C0QEU9 A0A8C0QEU9_CANLF Cilia- and flagella-associated protein 263 CCDC113 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cilium [GO:0005929] KMWERKVEIAETMQQ 1 4.2 0.98846 -0.22734 9.85323 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QEW7 A0A8C0QEW7_CANLF Neutrophil cytosolic factor 1 NCF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] phosphatidylinositol binding [GO:0035091]; superoxide-generating NADPH oxidase activator activity [GO:0016176] DDLKLPTDSQ;DINPENRIIPHLPAPRWFDGQ;PGSPREEQPATQ;TEIYEFHKMLKE 4 14.1 1.0038 -0.80585 0 0 0 0 9.1102 0 0 0 11.7077 0 0 0 9.9935 0 0 A0A8C0QEW9 A0A8C0QEW9_CANLF "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3" SPOCK3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] DDDDDGDDHDGYI;DDDDGDDHDG;DDEDEGDDDDDGDDHDG;DEDEIEDDDEDEGDDDDDGD;DEGDDDDDGDDHD;DEIEDDDEDEGDDDDD;DEIEDDDEDEGDDDDDGD;DEIEDDDEDEGDDDDDGDDH;DEIEDDDEDEGDDDDDGDDHDG;EDDDEDEGDDDDDGDDH;EDDDEDEGDDDDDGDDHD;EDDEDDIMNDEDEIEDDDED;EDEGDDDDDGDDH;EDEIEDDDEDEGDDDDDGDD;EIEDDDEDEGDDDDDGDDH;GAGAGGRCEGRQVR;GAGGAPAAL;GDDDDDGDDHDG;GDDDDDGDDHDGY;GPSRRVKR;LPICKDSLGWMFNRLDTNYDLLL;RGGGCGPG;SDGHTYSS;TDDEDDEDDIMNDEDEIEDDDEDEG 24 12.7 0.94308 0.083744 0 9.0954 0 0 0 0 0 0 0 5.69844 0 0 0 0 0 A0A8C0QEY2 A0A8C0QEY2_CANLF PR/SET domain 16 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; histone H3K9 methyltransferase activity [GO:0046974]; transcription coregulator activity [GO:0003712] DLDSDVDSDRDKAKD;DMSDGSDFEDVNTTT;EEQPGGLLALEPMPTL;EVCHKSYTQFSNLCRHK;GAPRATWKEADFG;HKRMHADCRTQIK;KPEDVEEEEEE;LSSGGSEQAHECKDC;LVSAVSSSGQGATAAAGPDDK;VHVKEGAYSLGT 10 12 0.98634 -0.4211 9.58069 0 0 0 0 0 7.73152 10.6551 9.22139 0 10.4226 0 0 4.4161 7.18269 A0A8C0QEZ9 A0A8C0QEZ9_CANLF Opioid growth factor receptor (OGFr) conserved domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] opioid growth factor receptor activity [GO:0140625] FILHEALV;GGGGGGGG;KKAAPGGP;PAPDGDAE;PGGGGGGG 5 7.5 1.003 -1.6305 9.70544 10.1211 9.64292 0 0 7.42131 0 10.4986 9.65823 9.59429 9.62419 9.3755 9.80074 9.90473 10.6495 A0A8C0QF00 A0A8C0QF00_CANLF Lipid-binding serum glycoprotein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] CCHWKSWSLGP;DEALPFLLQKIVC;IVCPLATT;LEGLLHITL;LSLQEILRLKVIKNIRIGVRL;VHIDGHTATITQPGSLMLL 6 18.6 0.98498 0.035491 6.40926 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QF08 A0A8C0QF08_CANLF SUN domain-containing protein SUN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AALSLKQSSVADQV;ETKTALLSL;SQFLLRGG;WWAAKGSSRQHDVWESRDASHFQTE 4 8 1.001 -0.70573 0 0 10.8768 0 0 7.28697 12.3587 12.574 0 0 0 0 8.45311 10.223 0 A0A8C0QF21 A0A8C0QF21_CANLF WH1 domain-containing protein HOMER2 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled glutamate receptor signaling pathway [GO:0007216] cytoplasm [GO:0005737]; postsynaptic density [GO:0014069] G protein-coupled glutamate receptor binding [GO:0035256] AERDNQNLEDKVRS;DRLRNKIDELEEQCSEINREKERN;PTQASSVNGTDD;VTVSYFYDVT 4 16.9 0.98596 -0.23237 0 0 0 7.854 0 0 0 0 0 0 0 0 0 0 8.40412 A0A8C0QF24 A0A8C0QF24_CANLF Transmembrane protein 225B TMEM225B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IFPFWVRLVNEESH;SPIDSKSLQVPVFF;VFFSGLFENCF 3 14.1 0.86528 0.17518 0 0 7.91892 0 0 0 0 0 7.72656 0 7.7198 8.35231 0 0 0 A0A8C0QF31 A0A8C0QF31_CANLF Sidekick cell adhesion molecule 2 SDK2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] GQFSKDTER;IALVGLIFILLLVFVLIIRGQ;LLVFVLII;QASMVCGV;SFPALELNNRRLSVKNSFCRKN;SIMIQWQPP;TESDSGEPDHATV;VDVKGSSPLWLKVKDLAEG;VGLIFILLLVFVLI;VTARPNFQDSI;VVIALVGLIFILLLVFVLIIRG 11 5.3 1.0002 -2.8196 0 6.76514 0 8.17687 3.97131 0 0 6.8759 0 0 0 8.75926 10.4366 8.64818 0 A0A8C0QF39 A0A8C0QF39_CANLF Transmembrane protein 216 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020] SILLFFCGSELLLEV 1 10.1 0.95096 0.053901 0 0 0 7.11707 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QF42 A0A8C0QF42_CANLF Substance-K receptor (NK-2 receptor) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] tachykinin receptor activity [GO:0004995] SHNIWYFGR;YVLPLLVMLLAYSVIGLTLW 2 7.6 0.99115 -0.21345 0 0 0 0 0 9.21001 0 11.2367 0 0 0 0 0 0 0 A0A8C0QF49 A0A8C0QF49_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein SCTR Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EVQLFFEL;HYIIFAFSPE;LNGEVQLEVQKKWQQ;MRDAEGGARCPP;YLHTLLVISFFSERKCL 5 11.7 1.0025 -1.0227 0 0 8.75626 0 9.27585 9.0739 0 9.02015 10.1561 0 8.42752 8.73684 0 8.89467 0 A0A8C0QF54 A0A8C0QF54_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP39 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; spliceosomal complex assembly [GO:0000245] spliceosomal complex [GO:0005681] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] KKKKTIVT 1 1.7 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 6.79194 0 7.42316 0 0 7.1644 A0A8C0QF69 A0A8C0QF69_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DFTIPYMVY;MIGERMAVNIM;PYMVYLQSSPEPC;SPEPCVGSLIHPEWV;STAGVVLA 5 20.6 1.0032 -0.89294 0 0 0 0 0 0 0 0 13.3246 0 13.2443 0 0 0 0 A0A8C0QF78 A0A8C0QF78_CANLF Nipped-B protein NIPBL Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; digestive tract development [GO:0048565]; embryonic viscerocranium morphogenesis [GO:0048703]; establishment of protein localization to chromatin [GO:0071169]; heart morphogenesis [GO:0003007]; mitotic cohesin loading [GO:0061780]; regulation of gene expression [GO:0010468]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414] Scc2-Scc4 cohesin loading complex [GO:0090694] chromatin binding [GO:0003682] CVVHLPSS;DTEEEERLWRDLIMERVT;DTGISVRKRVIKILRDI;EEPLFIMHHI;EHLDPDEEEEEGE;GAVVNKVT;HLDPDEEEEEGEV;ISVRKRVIKIL;KQCNDAPISVLQED;MDQQEDML;NLACFPYQ;RKRVIKILRDIC;SEEEVSRPRK;SKDDKRTEGNKSKVDSNKTHPDNKA;TDPEPAMRNKADQQLVE;VIVMLYNKVC 16 6 0.99686 -4.4125 10.7996 10.8971 11.8174 10.1196 0 0 7.1822 0 0 0 0 9.24303 0 8.96824 0 A0A8C0QFA0 A0A8C0QFA0_CANLF Chromatin accessibility complex subunit 1 CHRAC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] DEENDSDDGSDGD 1 10 0.94435 0.059561 0 0 0 6.33885 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QFA3 A0A8C0QFA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ILLSQPYSTCH 1 15.3 0.9841 0.035491 0 0 0 0 0 0 0 0 0 0 0 9.70196 0 0 0 A0A8C0QFB3 A0A8C0QFB3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;LSPLLLNIVLEVLASAIRQ;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RMGNINKAGNNKCW;SPLLLNIVLEV 7 6.4 0.9875 -0.4793 0 0 0 0 0 0 0 0 0 5.98039 0 4.39458 8.84856 0 0 A0A8C0QFD6 A0A8C0QFD6_CANLF DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) DDB1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; biological process involved in interaction with symbiont [GO:0051702]; ectopic germ cell programmed cell death [GO:0035234]; epigenetic programming in the zygotic pronuclei [GO:0044725]; negative regulation of apoptotic process [GO:0043066]; negative regulation of developmental process [GO:0051093]; negative regulation of reproductive process [GO:2000242]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle phase transition [GO:1901990]; spindle assembly involved in female meiosis [GO:0007056]; UV-damage excision repair [GO:0070914]; viral release from host cell [GO:0019076]; Wnt signaling pathway [GO:0016055] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] cullin family protein binding [GO:0097602]; damaged DNA binding [GO:0003684]; protein-containing complex binding [GO:0044877]; ubiquitin ligase complex scaffold activity [GO:0160072]; WD40-repeat domain binding [GO:0071987] KLNVDSNEQG;QDPQGRHVKTYEVSLREKE;TEPATGFIDGDLIE;TTDEERQHLQ 4 4.6 1.0025 -1.1325 0 0 0 0 0 0 0 0 0 0 0 0 10.4777 0 9.11291 A0A8C0QFE7 A0A8C0QFE7_CANLF "PWP1 homolog, endonuclein" PWP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033140]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA processing [GO:0006364] Golgi apparatus [GO:0005794]; nucleolus [GO:0005730] H4K20me3 modified histone binding [GO:1990889]; histone chaperone activity [GO:0140713] DPYVTLKDTEQYEREDFLIKPSDNL;KKKKKKGKKS;SKLSKKKKKKGKKSSS;SLVHSRDMKMGV;VEWLNFDP 5 12.2 1.0032 -0.8938 0 0 0 0 0 0 9.85354 0 0 0 3.5008 0 8.18001 0 0 A0A8C0QFE9 A0A8C0QFE9_CANLF MLLT10 histone lysine methyltransferase DOT1L cofactor MLLT10 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DNASQKVTVYFT;GMQTVTSTIP;PMPATLANSASGLGL;PSDILGMLKS;QQHHHQQHHQPELQ;RYNKTCYICDE;SELLNAIHNDRD;SHSQDKHHEKEKKKYKEKDKHKQKH 8 10.1 1.0015 -0.70166 10.4132 9.45088 0 0 0 6.13836 0 7.07221 0 0 0 9.44228 0 0 0 A0A8C0QFG0 A0A8C0QFG0_CANLF Ig-like domain-containing protein TREML2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSQIVTVSPSDARASSAGPASIS;RSTPLAHLANILKSGIVV;TGPRRTMGSQIVTVS;VLVKPRIRERQVL;VYGFWKKRHM 5 18.3 0.99388 -0.054738 0 0 0 0 0 0 8.45162 0 0 4.28821 0 0 5.38191 6.40613 13.1076 A0A8C0QFG1 A0A8C0QFG1_CANLF Aldo-keto reductase family 1 member A1 (EC 1.1.1.19) (EC 1.1.1.2) (EC 1.1.1.20) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (Glucuronolactone reductase) (S-nitroso-CoA reductase) Canis lupus familiaris (Dog) (Canis familiaris) aldehyde catabolic process [GO:0046185] apical plasma membrane [GO:0016324]; cytosol [GO:0005829] alcohol dehydrogenase (NADP+) activity [GO:0008106] ATKKKKKK;GVNKAIRAATKKKKKKKI;IRAATKKKKKKKI;LGSSDRAWRDPD 4 8 0.92744 0.10787 0 0 0 0 0 0 0 0 7.83845 0 0 4.72318 0 9.55419 0 A0A8C0QFH6 A0A8C0QFH6_CANLF Coiled-coil domain containing 57 Canis lupus familiaris (Dog) (Canis familiaris) AAGAAEPGQRQHRSTRQK;DVGRYKQQLSAAADRERCLERE;EAAAKAPDHVMVL;EEETKESFPSYEI;LDPDIIQHELSRDVDQVHLE;QRRCWRLPYFREARPR;RDHYRKSEDLI 7 11.1 1.0018 -0.96402 0 0 6.6335 0 8.86598 4.37712 9.10016 0 0 0 0 0 8.19279 0 0 A0A8C0QFI7 A0A8C0QFI7_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2S TNNI3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] ATP binding [GO:0005524]; transferase activity [GO:0016740] VLIRDSCPAG 1 4.1 0.99892 -0.61146 0 0 0 0 9.88241 0 0 0 0 0 0 0 0 0 0 A0A8C0QFI9 A0A8C0QFI9_CANLF Homeobox B2 HOXB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" FAVDSCLQLSGGLSPSLQ;FFTSTLCAIDLQF 2 9.1 0.39865 0.55915 5.96116 11.9386 0 0 0 0 0 0 9.94106 0 0 0 0 0 12.6882 A0A8C0QFL5 A0A8C0QFL5_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 14 ADAMTS14 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AYKYIIHEDLLPL;GVCGGDNS;NGTHKAMPAKACPGDREARRPC;RQPLRRECVYT;VLDRYCSI;VQRHLCDHRRRP;YIHQNAKHSWIPYEPEDDA 7 7.6 0.98361 -0.2526 0 0 8.967 0 0 0 0 0 14.0188 0 0 0 10.5134 6.70874 0 A0A8C0QFM1 A0A8C0QFM1_CANLF Presenilin (EC 3.4.23.-) PSEN1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563] axon [GO:0030424]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; synapse [GO:0045202] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]" HRLSCTALYGPISIPSI;QNAQMSEDNHL 2 6.2 0.98416 0.046227 0 0 0 0 0 0 0 10.9416 0 0 0 0 0 0 0 A0A8C0QFM3 A0A8C0QFM3_CANLF Protein phosphatase 1 regulatory subunit Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977]; regulation of glycogen catabolic process [GO:0005981] protein phosphatase type 1 complex [GO:0000164] protein phosphatase regulator activity [GO:0019888] AACPRAPTAASGRRG;DTFSFDISLPEKIQSY 2 8.2 0.98552 -0.23555 0 0 7.3535 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QFM4 A0A8C0QFM4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MDAFLESHKL;MNEKGEITTNT;YWDFIKRRSFCTAKDTVNKIKDN 3 6.9 0.97596 0.046436 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.65206 A0A8C0QFM6 A0A8C0QFM6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PLHPEASGAPGA;SGPGGPGSPGRPSR 2 5.8 0.98318 -0.25395 0 0 0 0 0 0 0 0 0 10.4901 0 0 0 0 0 A0A8C0QFP4 A0A8C0QFP4_CANLF Prenylcysteine lyase domain-containing protein GRPEL2 Canis lupus familiaris (Dog) (Canis familiaris) prenylcysteine catabolic process [GO:0030328] prenylcysteine oxidase activity [GO:0001735] AGEDCSSEDPPDEL;IFSGEHFVL;SGEHFVLEETD;VEELLYSLGESAFV;YGISFLRLQMWVE 5 9.5 1.0015 -0.70072 0 10.7099 7.62234 0 10.7643 10.4943 11.5963 11.5119 7.92297 0 0 11.3254 0 10.7882 0 A0A8C0QFQ8 A0A8C0QFQ8_CANLF Nucleoporin 155 NUP155 Canis lupus familiaris (Dog) (Canis familiaris) nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] DFIVQFLEQQVCTL;EDGGDLAYFD;ESLKEYQKISNQVDL;IARTIDRS;LVSAPNNPTVSG;LWRYYEKNRSFSN;NTQQMQQELQRKFHEAQL;VGGDGEEIERFFKLHQEDQA;VRHLLVLATP;WNYEDGGDLAYFDGL 10 9.8 1.0026 -2.1775 7.26519 8.76676 0 0 2.94253 0 6.59473 9.64174 10.98 4.99272 8.99893 9.03257 9.18148 0 4.81178 A0A8C0QFT0 A0A8C0QFT0_CANLF FIST C-domain domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FFFLLLFLLLLLLLLLLLLLLL;FFLFFFLFSLLLLLLLLLLPLL;FVLKKCNEVKDDDLFHSYTTIMV;LFLLLLLLLLLL;LFSLLLLLLLLLLPLLL;LLLFLLLLLLLLLLLL;LLLFLLLLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLF;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLL;LLLLLLLLLLLLLFFF;LLLLLLLLLLLLLL;LLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLF;LLLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLLFF;LLLLLLLLLLLLLLLLLLLFFFF;LLLLLLLLLLLLLLLLLLLL;LLLLLLLLP;LLLLLLLP;LLLLLLPL;LLLLLPLL;QEIEIGESGFALLFPQIEG;VGANNYLQRVVSAFSDMNVI 30 19.8 0.99263 -0.14117 10.4577 7.1236 0 0 0 4.20304 9.19623 0 5.60828 4.38163 0 7.29453 3.98495 0 10.2271 A0A8C0QFU8 A0A8C0QFU8_CANLF Fatty acid synthase (EC 1.1.1.100) (EC 1.3.1.39) (EC 2.3.1.38) (EC 2.3.1.39) (EC 2.3.1.41) (EC 2.3.1.85) (EC 3.1.2.14) (EC 4.2.1.59) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; hydrolase activity [GO:0016787]; lyase activity [GO:0016829]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177] AVSPCGVSARG;EALCHVPEHA;EPAGLAPESLEY;EVRTGGMAF;GGGAGGAA;GGGGGGGA;GGGGGGGG;IAPTLLKALKKVIREPK;LEASQSFEVSENG;LLKALKKVIREPKPRSARWLSTSI;LVSPVLFQEALCHVPEHA;NLDSTLADLGLDSLM;PDFLWDVPSSW;QSPAPTHNSLFLFDGSHS;RAACPELDY;RVVASVDLIQHSHAGLDP;TVLIHSGSGG;VGDPQELNSIDRALCSTRREP;VGQAAIAI 19 7.9 0.99686 -4.1975 0 4.62837 0 10.1523 8.33365 10.4857 8.27924 0 11.0924 0 10.5285 9.54664 9.18847 0 8.88643 A0A8C0QFV6 A0A8C0QFV6_CANLF LIM domain 7 LMO7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051] metal ion binding [GO:0046872] AQQEAERENY;DLEMPTLDPD;EADGTFPSQFLLLQALQTYSD;EEWQRAQQEAERENYK;ENGVLLCDLVNKLKPGVIKKIN;FSGIFVASVEAGSPAEF;ISINQTPG;LQEKYQREQEKLREEWQRAQQEAER;LRYEEMQKIKSQLKEQDQKWQDDL;QKKKEEREEIE;QQDQEEQER;QRSSKKEQAPSEAELERQQILQEMR;RPIDSYDIPKREEQSSGL;RWAWDQEEERRRQERWQREQ;RWQREQDRLLQEKYQREQEKLREEW;SIPPPSSAGS;SYTMDDAWRYNGDVEDDK 17 15.7 0.97493 0.047166 0 0 0 0 0 0 8.42601 8.09513 0 0 0 0 0 0 0 A0A8C0QFX4 A0A8C0QFX4_CANLF Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020]; receptor complex [GO:0043235] protein tyrosine phosphatase activity [GO:0004725] AVILIILIVIAILLFKR;AVILIILIVIAILLFKRK;GAEELTKEDEMPVG;GPVLAVILIILIVIA;GVITQYSVAYE;IILIVIAILLFKR;ILIILIVIAILLFKRK;LAVILIILIVIAI;LIILIVIAILLFKRKRTH;PVLAVILIILIVIAILLFKR;PVLAVILIILIVIAILLFKRKRTH;RGYRVYYTPDARRPLSAWHKH;SRTMPMEQVFAKNFRVAAAMKTSVL;TGPVLAVILIILIVIAIL;VHCSAGVGRTGCFIVIDAMLERMKH;VILIILIVIAILLFK;VILIILIVIAILLFKRK;VILIILIVIAILLFKRKR;VILIILIVIAILLFKRKRT;VILIILIVIAILLFKRKRTH;VILIILIVIAILLFKRKRTHS;VTGPVLAVILIILIV;VTGPVLAVILIILIVIAILLFK 23 6.5 0.56784 0.40134 3.7041 11.4083 6.75649 9.01092 3.64881 6.75609 6.58495 12.0936 10.7664 3.63981 3.83996 0 10.4707 6.4455 7.52732 A0A8C0QFX9 A0A8C0QFX9_CANLF Autophagy-related protein 9 ATG9B Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; lipid transport [GO:0006869] phagophore assembly site membrane [GO:0034045] ATVARSFIP;FSLVHPQWRPPGHSSK;LSSVPWAEV;SPQLLLQAAL 4 5.3 1.002 -1.235 0 0 0 0 9.037 10.9958 7.94498 7.79188 0 0 0 0 0 0 0 A0A8C0QFY0 A0A8C0QFY0_CANLF Cytochrome P450 family 2 subfamily W member 1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LDTTPAPA 1 1.7 0.98408 -0.23825 0 0 0 9.64015 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QFZ2 A0A8C0QFZ2_CANLF Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of chromosome separation [GO:1905818] cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ITNNERVVVKILKPVKKKKIKRE;KILKPVKKKKIK;NNERVVVKILKPVKKKKI;QPCADNAV;RVVVKILKPVKKKKIK;RVVVKILKPVKKKKIKR;RVVVKILKPVKKKKIKRE;VKILKPVKKKKI;VKILKPVKKKKIKREVKI;VVKILKPVKKKKIK;VVKILKPVKKKKIKREVKI;VVVKILKPVKKK;VVVKILKPVKKKK;VVVKILKPVKKKKI;VVVKILKPVKKKKIKR 15 9.9 0.945 0.076707 11.0118 0 0 0 6.85761 6.14788 5.83842 6.42053 6.41696 10.9095 6.09748 11.9009 11.6299 0 6.25697 A0A8C0QFZ4 A0A8C0QFZ4_CANLF Metalloendopeptidase (EC 3.4.24.-) TLL1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EFEIEQHQ;FSEFEIEQHQECA;HTTGGFGD;HYARNTFSRGMFLD;NEVCKYDYVEIWSG;VNTMGSYMCQC;YPDDYRPMKECV 7 7.5 1.0024 -1.7695 0 0 0 7.44311 7.58894 6.94334 0 0 0 13.4924 0 0 0 13.4597 0 A0A8C0QG05 A0A8C0QG05_CANLF Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) DRAXIN Canis lupus familiaris (Dog) (Canis familiaris) anterior commissure morphogenesis [GO:0021960]; axon guidance [GO:0007411]; commissural neuron differentiation in spinal cord [GO:0021528]; dorsal spinal cord development [GO:0021516]; hippocampal neuron apoptotic process [GO:0110088]; negative regulation of axon extension [GO:0030517]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] GLNNKCFDDCM;NKCFDDCMC;VEGLRCYARFHRN;VLFAALLLLLELRPAGSL 4 12.9 1.0029 -0.98296 0 0 0 0 0 0 4.55876 0 0 6.5266 8.72765 0 6.34894 0 4.78152 A0A8C0QG10 A0A8C0QG10_CANLF C2H2-type domain-containing protein ZNF462 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEEDYYGS;DLETNSMLNDSSSD;DNEVEIEVELD;EAQEMEWLPFR;EVELDREEEPTE;HYQKRHDIDAYYTHCLAASRTI;KFCVRYFRSK;LLNTQTPIYGTE;MNRFQCPFCPF;PLCLYHTKY;QQEDAVINVEDDEEEEEDN;TKKNKKTKKRKKERKK;TPIYGTEHNNENTD;VGVLVHYQ;YCSFVSAFRHNLD;YTNPIRKGLAAHYQKRH 16 7.3 0.96245 0.049233 0 0 0 0 0 0 0 8.43204 0 0 0 0 0 0 0 A0A8C0QG22 A0A8C0QG22_CANLF "Beta-galactoside alpha-2,6-sialyltransferase 2 (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2) (ST6Gal II) (Sialyltransferase 2)" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] sialyltransferase activity [GO:0008373] VHVYEYIPSI 1 1.9 0.99314 -0.052932 0 0 0 0 0 0 0 0 0 0 0 9.11725 0 0 0 A0A8C0QG54 A0A8C0QG54_CANLF DBIRD complex subunit ZNF326 (Zinc finger protein 326) ZNF326 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DHIKGKQGENPF;DNHSGGGG;EEEEEEEEEEEVGEVEEAEEVEE;EEGVGDTEE;FEDDYTHSAC;GVGDTEEAGDIEGVGEG;KKPKLTKPVEKMSLS;TVHCSACSVYIPALHGS;VTADDHMMKVE;VTVAAARG 10 22 1.0032 -2.4345 7.42004 8.89482 7.19977 6.41447 8.48043 0 0 0 0 7.43555 9.12848 8.07799 8.69818 0 7.8399 A0A8C0QG62 A0A8C0QG62_CANLF Peptidase S1 domain-containing protein LOC490629 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] serine-type endopeptidase activity [GO:0004252] DIMLLLVRRPPCSSCP;PVGAETEKI 2 7.9 0.99043 -0.21127 0 10.9476 0 0 6.67934 0 0 0 0 0 10.5632 0 0 0 0 A0A8C0QG71 A0A8C0QG71_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metallopeptidase activity [GO:0008237] DENCDHECNHTLTG;GVCDMDCNYERFNFD;LSSCQRGETYSS;QIDFQHRQLADA;RCYFHDGDGVCEEFEQKT 5 4.4 0.98794 -0.48434 0 0 7.29581 0 0 0 0 0 7.66945 0 0 0 0 0 5.88584 A0A8C0QG76 A0A8C0QG76_CANLF PHD-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982] GTSAEAMQVPLEEEDE;IPQAPVRPETPNR;IVSSQEEEE;PGCNKPDDGSPMIGCDDCDDWYHWP;SELYGRTDPI;VEVKKKLKKELK 6 9.1 1.0022 -1.0134 0 9.70917 0 0 0 0 0 5.78285 0 0 0 0 6.22545 0 0 A0A8C0QG77 A0A8C0QG77_CANLF Tetratricopeptide repeat protein 38 Canis lupus familiaris (Dog) (Canis familiaris) CGGAPGRHP 1 3.7 0.99196 -0.27195 0 0 0 0 7.18765 0 0 0 0 0 0 0 0 0 0 A0A8C0QG78 A0A8C0QG78_CANLF ZZ-type domain-containing protein DTNB Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EGAAESGEFHRGGSLSLRVRP;NPDALTHQIP;PEKAQQNPTL 3 4.6 0.99714 -0.11244 0 0 0 0 0 7.53947 0 0 0 0 0 0 0 12.5201 0 A0A8C0QG93 A0A8C0QG93_CANLF C-X-C motif chemokine Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009]; growth factor activity [GO:0008083] AAPRAPRAPRPLGAPRLLLLLLLL;APRLLLLLLLLLLL;APRLLLLLLLLLLLGPAGRR;GAPRLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;PLGAPRLLLLLLLLLLL;RLLLLLLL;RLLLLLLLL;RLLLLLLLLLLLGPAGRRAAGA;RPLGAPRLLLLLLLLLLLG 13 12.8 0.98956 -0.31884 0 5.25735 5.22195 6.2869 0 7.03276 6.88753 5.48742 0 0 0 0 4.75216 0 0 A0A8C0QGA2 A0A8C0QGA2_CANLF Synaptic Ras GTPase activating protein 1 SYNGAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096] DLQGDGPGGRL;FLELEWGSMQ;GGGGAAPG;HSHESLLS;QVEKDSQIKSIIGSP;VLPQLSKEALLKLG 6 5.5 0.95163 0.053886 0 0 0 0 0 0 7.35702 0 0 0 0 0 0 0 0 A0A8C0QGB4 A0A8C0QGB4_CANLF Kinesin-like protein KIF3C Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EKAAIQDDRSLVSEEK;EVKTKKLKKL;GGGGGGGE;GGGGGGGG;GPASHSYDESLST;GVNNSQMKKRPT;KAEIQDQHDEYIRVRQDLEEAQ;KVVARCRPLSRKEEAA;LEEEKAAIQDDRS 9 14.1 1.0039 -0.82408 0 0 10.5173 5.25931 0 9.37862 0 9.86867 0 0 10.3794 0 12.2264 0 0 A0A8C0QGB6 A0A8C0QGB6_CANLF MAP7 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] TYTHSLSG;VAWAPGGG 2 1.9 1.0021 -1.3703 10.4434 0 0 0 6.82883 0 0 0 0 0 0 0 7.19298 2.36174 0 A0A8C0QGB8 A0A8C0QGB8_CANLF Tubulin tyrosine ligase like 6 TTLL6 Canis lupus familiaris (Dog) (Canis familiaris) microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein modification process [GO:0036211]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] 9+0 non-motile cilium [GO:0097731]; ciliary basal body [GO:0036064] tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] EVKSASAVNILTHT;KDLLARNMSRMLKMFPRDF;KKKRKKKRLVI 3 5 0.98671 -0.45917 0 0 0 8.89869 3.21704 0 0 0 0 0 0 0 0 0 0 A0A8C0QGC1 A0A8C0QGC1_CANLF LIM zinc-binding domain-containing protein NEBL Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] AAGLAGGCHSGSSEPPAAAAQPPP;DLSPGVPPRVAAPGP;GGGGGGGE;GGGGGGGG;PILSPEEKSKWNTVALNSVHFQ 5 12.4 0.99263 -0.19279 0 4.65317 0 0 0 0 9.13183 0 0 0 0 0 0 0 0 A0A8C0QGC4 A0A8C0QGC4_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] ACNHYSFYNHNLQSRVGNP 1 8.6 0.94906 0.050019 0 10.0443 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QGC6 A0A8C0QGC6_CANLF Dehydrogenase/reductase 1 DHRS1 Canis lupus familiaris (Dog) (Canis familiaris) VLSHASSL 1 2.6 0.98989 -0.26172 0 0 0 0 0 7.39806 0 0 0 0 0 0 0 0 0 A0A8C0QGE2 A0A8C0QGE2_CANLF Pepsin A (EC 3.4.23.1) PGA Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] HNRFNPQESSTY;TVGLQSEMWQLHVTWGGQLL;VDPDTGVYYESMRNYLD 3 11.6 0.98926 -0.21812 0 0 0 0 0 0 0 0 8.5585 0 0 0 0 0 0 A0A8C0QGE6 A0A8C0QGE6_CANLF Zinc finger protein 300 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DIPNWIYPGK 1 1.7 0.98901 -0.26139 0 0 0 0 9.39894 0 0 0 0 0 0 0 0 0 0 A0A8C0QGE8 A0A8C0QGE8_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) humoral immune response [GO:0006959]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ESHSRRLEMTNKQLLLRI;FINPETQMPNTL;LGGPPTPA 3 9.8 0.99214 -0.16717 0 0 0 0 0 0 0 7.44791 0 10.6266 0 8.82359 0 0 0 A0A8C0QGF4 A0A8C0QGF4_CANLF Leucine rich repeat containing 45 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ALVNCLPRNR;DAQARASQL;MARSSRASAARMGQLQ;QAKEHRLEQQEAAERESK;QVRLEEQQRLAHLEEKLRL;VTRVRVELQEQNGRLQ 6 13.7 1.0018 -0.67295 0 0 0 0 0 7.20828 0 9.73655 0 0 0 0 0 5.2093 8.95847 A0A8C0QGH4 A0A8C0QGH4_CANLF Calmodulin-lysine N-methyltransferase (EC 2.1.1.60) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] calmodulin-lysine N-methyltransferase activity [GO:0018025] GPASSGASRGLQVSEPLGAA;PLLLILTK;VGAWFQYTSVF 3 12.1 1.0006 -0.6123 0 0 0 0 0 0 0 5.12284 0 0 0 0 0 0 0 A0A8C0QGH5 A0A8C0QGH5_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032] actin binding [GO:0003779]; calmodulin binding [GO:0005516] GGGGGGRH;GVDIGVKYSEKQEQLQRRHHEA;RRHLYDPKNHILPPRDHSTISL;SWGGGGGGRHPQAGTSP 4 15.8 0.99267 -0.17161 8.93826 0 5.14445 0 0 0 0 0 9.46624 0 0 0 0 0 0 A0A8C0QGI9 A0A8C0QGI9_CANLF WD repeat domain 17 WDR17 Canis lupus familiaris (Dog) (Canis familiaris) DLLLMTPDNELHL;GLKIQGPV;GVSTQSPTKNH;PVFFLEDG;STHFDRKVSP 5 3.8 1.0018 -1.3086 5.86148 0 11.1139 10.9181 0 0 0 0 0 0 0 0 0 0 7.51672 A0A8C0QGL5 A0A8C0QGL5_CANLF DLG associated protein 3 DLGAP3 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] PHASHHHHHHHHHHHHQ 1 1.8 0.98299 0.046227 0 0 0 0 0 0 0 0 0 8.47614 0 0 0 0 0 A0A8C0QGL9 A0A8C0QGL9_CANLF Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ASS1 Canis lupus familiaris (Dog) (Canis familiaris) arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] cytoplasm [GO:0005737] argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524] SLRLKEYHRLQ 1 2.8 0.98496 0.035491 0 0 0 4.90009 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QGN0 A0A8C0QGN0_CANLF Zinc finger protein 214 ZNF214 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HYFPHSLIPDL;KEIYYWNSQCVL;LHVHQRVHTGEKPY;YGCDQVDDNFTQS 4 8.4 0.98757 -0.3351 0 0 0 0 0 6.63654 0 0 11.9304 0 0 0 10.6127 0 0 A0A8C0QGP9 A0A8C0QGP9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM17 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; negative regulation of AIM2 inflammasome complex assembly [GO:0140972]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]; protein autoubiquitination [GO:0051865]; suppression of viral release by host [GO:0044790] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AELEGRCQLPALGL;EHLRKQMEDALLF;KGELFAGNGFWILVFLGS;VLSEDRRSVRR 4 8.1 0.947 0.085331 16.4347 15.7809 16.2237 9.98271 12.2904 11.2759 16.4073 16.6492 16.7316 0 16.6479 0 9.23328 0 16.5002 A0A8C0QGQ4 A0A8C0QGQ4_CANLF Leucine rich repeat containing 46 LRRC46 Canis lupus familiaris (Dog) (Canis familiaris) ELQTVRLDREGI;TDLPQLPGEPMAR 2 8.5 0.99437 -0.077986 9.9635 0 0 6.21327 0 0 0 0 0 0 0 0 0 9.44014 0 A0A8C0QGU8 A0A8C0QGU8_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PSAGTSASVKDPVV 1 2 0.99049 -0.13789 9.34254 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QGU9 A0A8C0QGU9_CANLF Origin recognition complex subunit 1 ORC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677] MKLTEPHQVYVQI;TSHRIRRKSSFLTLNRIR 2 3.8 0.92423 0.10812 0 9.82742 0 0 0 0 0 0 0 0 0 0 7.48196 0 0 A0A8C0QGV1 A0A8C0QGV1_CANLF Ankyrin repeat domain 17 ANKRD17 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; RNA binding [GO:0003723] AAAALTRMRAESTANAGQ;EGIGGNQDKVDWCNPGM;EMVALLLGQGANINAQT;EQLSEGDYARLQQV;HTALMEACMDGHVE;LDQDDLENP;LETASKLL;PAIDIDAQTESNHDT;PVLGQAQLA;QEKEKHKVE;QVNMPADSFESP;VGHSGIWSF 12 6.1 1.0017 -0.74327 0 0 0 0 0 0 0 0 0 0 0 3.59419 0 8.20389 0 A0A8C0QGW4 A0A8C0QGW4_CANLF Butyrophilin like 9 BTNL9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ETSVVVQGDAHNNVSCSIQNSFLIQ;FLSTNFSR;LDPASAHHSLE;SLFNLETSVVVQGDAHN;TANLERLQTELDWRRAEGQAEWR 5 14.8 1.003 -1.529 0 0 0 7.91259 13.5106 0 0 11.99 0 0 0 0 10.5119 0 0 A0A8C0QGW8 A0A8C0QGW8_CANLF Cation-transporting P-type ATPase N-terminal domain-containing protein ATP1A3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; neuron projection maintenance [GO:1990535]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376] axon [GO:0030424]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; sodium:potassium-exchanging ATPase complex [GO:0005890] amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; protein-folding chaperone binding [GO:0051087] KDFTSEQIDEILQ;VLDNYQIYQ;YSFLIFVYDEIRK 3 2.9 1.0041 -0.80959 0 0 0 0 0 0 0 0 0 0 0 0 9.5167 0 0 A0A8C0QGY0 A0A8C0QGY0_CANLF C2H2-type domain-containing protein ZNF341 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EALRVRLGWGQCA;FTKNFDLQQHIRS;KSHMTQHKNEQVYKC;LHAHIHSGEKP 4 5.9 0.9895 -0.50918 0 0 0 0 0 0 11.4246 0 0 0 0 0 0 0 8.06474 A0A8C0QGY6 A0A8C0QGY6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GVHYWELTV;MLGKDDKA;RRLIDAGRRSRRRRRRRRRRRRRWP;RRRRRRRRRRRWPRCWRRQAGRPPR;SESPQSRRASGSG 5 7.5 0.98985 -0.52788 0 7.3505 0 0 0 10.7689 0 0 0 5.11345 0 0 0 10.1792 4.71028 A0A8C0QGZ1 A0A8C0QGZ1_CANLF Proline rich 13 Canis lupus familiaris (Dog) (Canis familiaris) YPPPYPPPAPG 1 11.3 0.98471 0.035491 0 0 0 0 0 0 0 0 8.75275 0 0 0 0 0 0 A0A8C0QH07 A0A8C0QH07_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) TIE1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] LVSFSGDGPIASVRLHYR;PWLEGWHV;QRFFLTCVSG;VEPDRTTAEFEVPRLT 4 4.8 1.0021 -1.3926 0 0 0 10.6316 0 0 9.50076 0 0 0 9.44789 0 0 0 7.73016 A0A8C0QH14 A0A8C0QH14_CANLF Mesoderm induction early response protein 1 MIER1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AEIPVGICRYKEN;DEDADNDDNSGCS;EDDEDADNDDNSGCSGE;EDEEEEEEEEEGEDDEDADNDDN;EEEEEEEGEDDEDADNDDNSGCSG;EEEEEEGEDDEDADNDD;EEEEGEDDEDADNDDN;EEEGEDDEDADNDDNSGC;EEEMMEGETNFSSEIE;EEGEDDEDADNDDNSGC;EGGGGSSGSGYG;GASSGGGG;GEDDEDADNDDN;GVEAIPEGS;SEEDEDYIPSEDW;VAFYYMWK;VESSSPGGSATSDDHEFDPSAD;YGYDSTIRLPEEDEEE 18 23.5 1.0022 -1.2213 0 0 7.02292 0 0 0 0 0 0 9.71065 0 0 0 0 0 A0A8C0QH17 A0A8C0QH17_CANLF G-protein coupled receptors family 1 profile domain-containing protein LRRC20 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] LPPKALLAWSLGQ;PSQPPNSSWPPSQN;TINLEENNIVGEPSQ;TTLPALETINLEENNI 4 15.6 0.99563 -0.11447 0 0 0 0 0 0 7.91624 8.93846 0 0 0 0 0 0 9.0292 A0A8C0QH21 A0A8C0QH21_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APGQHPGPGQHPGPGQHRGPG;PGPGQHRGPG 2 13.2 0.99192 -0.20749 0 0 0 0 0 0 10.296 0 0 8.90289 0 0 0 0 0 A0A8C0QH35 A0A8C0QH35_CANLF Tyrosine-protein kinase (EC 2.7.10.2) Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] VEIVKSDISIP 1 1.8 0.79319 0.20992 0 0 12.8012 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QH45 A0A8C0QH45_CANLF Rho guanine nucleotide exchange factor 7 ARHGEF7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] lamellipodium [GO:0030027] guanyl-nucleotide exchange factor activity [GO:0005085] GAGGRAGA;GGGGGGGA;GGGGGGGG;LCYKEDLSKS;LVSCNNQQDLHEWVDHLQKQTK;NWGPLEPP;PGGGGGGG;TRVEEGGW;VEEGGWWEGT;VIGGGGWEPGGGGGGGGGA 10 6.2 1.0033 -1.6556 9.0886 0 0 0 0 0 0 8.93478 0 0 0 0 0 0 0 A0A8C0QH49 A0A8C0QH49_CANLF Rap guanine nucleotide exchange factor 5 RAPGEF5 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AISKSLEASGRI;EQERNVLVLKKVQG;KLARENCQFL;LVKKFIKIA;RKRKVLHLV;RSCVGSELVDWLLEHCP;VQLWVATEILLC;YCEFEREEEWQ 8 11.6 0.9999 -2.8429 0 12.248 0 0 6.12482 0 0 0 5.32337 0 0 0 10.8836 13.2207 10.3433 A0A8C0QH69 A0A8C0QH69_CANLF U2A'/phosphoprotein 32 family A C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U2 snRNP [GO:0005686] U2 snRNA binding [GO:0030620] ESETKRASGSRENV 1 9.1 0.99235 -0.065319 11.0825 0 0 0 0 0 0 0 0 0 0 0 0 11.2776 0 A0A8C0QH74 A0A8C0QH74_CANLF Nuclear factor 1 NFIC Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GKQAKREKKKKKKKAKKK;HIHTGGKQAKREKKKKKKKAKK;KKKKKKDKRKKKKPP;KKKKKKKAKKKKK;KKKKKKKAKKKKKK;TAIRYPPHLNPQDPLKDL 6 9.6 0.6859 0.26922 5.79826 0 4.32438 0 6.85125 6.9689 9.25165 0 8.0138 4.41954 0 0 3.13021 0 9.74982 A0A8C0QH77 A0A8C0QH77_CANLF Heat shock 70 kDa protein 4 HSPA4 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] EENEEPMETDQNAKEEEK;LKKPVVDCVVS;LWQIDREMLNLYIE;PIKMRFQESE 4 6.8 1.0026 -0.77178 13.8478 10.2855 0 9.75737 0 10.4334 0 0 0 0 0 0 0 0 0 A0A8C0QH79 A0A8C0QH79_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SLSGSSTRGG 1 13.3 0.98447 -0.25741 0 0 0 0 10.3673 0 0 0 0 0 0 0 0 0 0 A0A8C0QH95 A0A8C0QH95_CANLF Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein IRF2BP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; protein polyubiquitination [GO:0000209] nucleoplasm [GO:0005654] transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630] HSPKDPGGGGGPVRAGGASPAAS;LSACAPFNV;PGVPSPIAALK 3 7.4 1.0024 -1.0037 0 0 10.5844 0 5.09263 0 0 9.71596 10.149 7.72028 0 0 10.5901 0 10.7555 A0A8C0QHB3 A0A8C0QHB3_CANLF 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 DPH2 Canis lupus familiaris (Dog) (Canis familiaris) protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GVRAGRLRARRHYLVER;LGRPTPPKLA;QPFFTCCPDTGQTD 3 8.4 0.98808 -0.49271 0 0 0 0 0 0 0 0 0 0 6.28316 10.3768 0 8.84467 0 A0A8C0QHB5 A0A8C0QHB5_CANLF ADP ribosylation factor 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] TTIQRGDRGFNVETVE 1 17.2 0.99213 -0.03615 0 0 0 0 0 0 0 0 11.5072 0 0 0 0 0 0 A0A8C0QHB8 A0A8C0QHB8_CANLF Serine/threonine-protein kinase ATR (EC 2.7.11.1) ATR Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; regulation of primary metabolic process [GO:0080090] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; protein serine/threonine kinase activity [GO:0004674] HIMKSSPLMFVN;LPSTPCQNAEMRKQDVA;LQPAPLQFMNMQNL;LTQWARHKFQAL;LYAALKMESMEII;LYAAMHEPDGVAGVSAIRKA;NKGETFEVP;PKLLGILAFFNM;SMLDHLTQW;VLGFQVDAEYLLGP;VLHFGRSLQYG;VLRMKEAYTHAQISRN;VQDFLHEIYFL;YDTLKLVRAE;YPQQAMWMMTAVSKSSYPMRVNRCK 15 8 1.0015 -2.632 10.7499 11.0205 8.60707 0 8.59186 0 10.3691 11.8392 13.935 0 0 0 14.6913 11.913 13.0422 A0A8C0QHC6 A0A8C0QHC6_CANLF Cocaine- and amphetamine-regulated transcript protein CARTPT Canis lupus familiaris (Dog) (Canis familiaris) adult feeding behavior [GO:0008343]; cellular response to starvation [GO:0009267]; chemical synaptic transmission [GO:0007268]; intracellular glucose homeostasis [GO:0001678]; negative regulation of appetite [GO:0032099]; negative regulation of bone resorption [GO:0045779]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transmission of nerve impulse [GO:0051971] extracellular space [GO:0005615]; secretory granule [GO:0030141]; synapse [GO:0045202] neuropeptide hormone activity [GO:0005184] LLLLLPLL;RLRPLTLLGAALLLLLP 2 16.4 0.98338 0.046227 0 0 0 0 0 4.66573 0 0 0 0 0 0 0 0 0 A0A8C0QHG4 A0A8C0QHG4_CANLF Dynein heavy chain domain 1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AHALGTGRLPPPWR;CLSNYLNGALQGGAWLLLEAAQ;EAMEEDDDDS;EDLSNSGSETEEEEDPYGLQ;ELAQWEDLSNSGSET;FPPLRRQEL;GYKLQLNRNKNWWQ;HVLSGTDP;LEDMIQDL;LPLSALGK;LRTASPCQTVGPKEP;NLDLAKKLEDTQTSH;PFNFKQLQEDLDNSPRIQ;QALLQALGL;QEKEEAMEEDDDDSSEESN;QLVMMPCLPQIEAQ;SEGHPVML;SIQAWLERFPSVEREGVLA;SVEAWEAVHNCF;TLPLLLLHGLLLHRQLYGMKLQ;VFNLEQLL;WWAEMEEALL 22 6.7 0.99687 -5.8218 8.9493 12.2627 10.07 9.30214 8.11598 8.88956 8.08071 6.56377 0 10.1704 9.86776 0 10.0087 9.04655 12.1726 A0A8C0QHG8 A0A8C0QHG8_CANLF Solute carrier family 16 member 10 SLC16A10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AGSSIFTI;EEDGTPGR;QHLCLESRKATESWNRIR 3 6.8 1.0015 -1.3138 0 0 0 8.06517 0 0 2.90113 0 9.15548 0 8.43775 0 0 0 0 A0A8C0QHI6 A0A8C0QHI6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] RSRPDPAS 1 6 0.98939 -0.26225 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.6523 A0A8C0QHJ2 A0A8C0QHJ2_CANLF LIM zinc-binding domain-containing protein ABLIM3 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; lamellipodium assembly [GO:0030032] stress fiber [GO:0001725] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] FHKRLLQIQAPCWALSK;HGSPKVPR;HTAGYDMSLNGSPRSHYL;QRRASSPGYIDSP;VIQCYRCGDTCKGE 5 11.2 0.9874 -0.36118 0 0 0 6.75582 10.7193 0 10.9195 0 10.8945 10.5262 0 0 10.7015 10.9223 9.77418 A0A8C0QHL7 A0A8C0QHL7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PDSFPGEF;PSICCLQETHFRQ 5 4 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 7.41236 0 0 0 0 0 A0A8C0QHM3 A0A8C0QHM3_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP metabolic process [GO:0046034] "apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; proton-transporting V-type ATPase, V1 domain [GO:0033180]" "ATP binding [GO:0005524]; DNA binding [GO:0003677]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" AADPPAGSRAAGAR;GPPRPEGDGRDL;KSKAVLDYHDDNFAI;LAYQCEKHVLV;LPDGTQRSGQVLEV;NFAIVFAAMGVNMETARFFKSDFEQ 6 14.8 1.0025 -1.0109 10.4061 11.8865 0 0 0 0 0 0 0 7.89664 0 0 0 0 0 A0A8C0QHP6 A0A8C0QHP6_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]" nucleus [GO:0005634] RNA binding [GO:0003723] AEPEDPTPHSEG;ATPPTSGAPAGPGPTPTP;GPGGPKGG;GPKPGGGP;PGGPKPGG;VGSAPPASGSAPPATPPTSGAP;VIVEPLEQLDDEDGLPE;VSGPVPEPRRRRRRLPPARRRRRP;YHEHQANLLRQDLMRRQE 9 12.8 0.93342 0.091743 0 0 0 0 8.14817 0 0 0 0 0 0 0 0 8.67158 0 A0A8C0QHQ6 A0A8C0QHQ6_CANLF Platelet-derived growth factor receptor-like protein PDGFRL Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] VVYLNPDR 1 2.1 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 9.58513 0 A0A8C0QHR3 A0A8C0QHR3_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT17 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] AEEEKAKGP;ASLRRVKVLLVLNLIAVA;DRSIPDYRPTKCKELKY;GEIGLLDPGMDVYGGENIEL;GWKVATGQVTGFF;IQENRKRVILPS;LARYTKEGFLHLG;LSKSLGLI;SLRRVKVLLVLNLIAVAGFVL;YKSHVYIAW 10 22.3 1.0044 -1.0466 9.95947 8.36986 9.95353 0 0 10.4038 8.92997 0 10.2892 0 0 0 0 0 10.253 A0A8C0QHU4 A0A8C0QHU4_CANLF Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase I) Canis lupus familiaris (Dog) (Canis familiaris) oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573] HTCEQGDGVGP;VGNVWRQYQATG 2 2.8 0.98814 -0.26492 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.062 A0A8C0QHU6 A0A8C0QHU6_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALQMQMFVAL;SPDCDPRSNIQP 2 5.7 1.0006 -0.92687 0 9.93857 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QHW5 A0A8C0QHW5_CANLF Guanylate cyclase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cyclic nucleotide biosynthetic process [GO:0009190]; intracellular signal transduction [GO:0035556] lyase activity [GO:0016829]; nucleotide binding [GO:0000166] CIMFGKRHLTRE;ETLLSTVP;GECLHFIQHCEHSCI;GHSFHIDLLQHLLPGW;ISITNGPV;IVGDEQRQYLL;SLAMWFAQ 7 4.8 1.0019 -0.99404 12.7754 0 0 5.69176 0 0 5.67553 8.2723 9.82262 8.30492 8.24351 0 9.03843 0 9.25496 A0A8C0QHX0 A0A8C0QHX0_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] IPFTFISTRHLQ 1 6.2 0.98791 -0.22944 0 0 0 0 0 0 0 0 0 0 0 0 0 9.76539 0 A0A8C0QHZ0 A0A8C0QHZ0_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein phosphorylation [GO:0001933] CRWSPHDGCTAT;GVGESVRFSEA;GVSCCALCMPS;RAFPGPGML;SPPGLATVIAYAYTG 5 5 1.0038 -0.82995 0 11.7495 0 0 0 0 0 0 9.51235 9.58122 0 0 11.9127 0 0 A0A8C0QHZ2 A0A8C0QHZ2_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] DLHIQRVLRVNRT;GRFREQKSPESIWTPVPE;GRSGGGEA;GVVSLGGRPVVL;PAPLLLLLL;PTGPSDPA;SVFLEEFETYRPDRCGRSG;VVLAVFSPSNSI 8 10.3 0.99325 -0.17045 0 0 0 0 0 0 0 0 0 0 0 0 0 9.35114 0 A0A8C0QHZ6 A0A8C0QHZ6_CANLF "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase (EC 2.4.3.2) (Monosialoganglioside sialyltransferase)" Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] ILIWFWTD;KPIEEPPGQPLGY 2 8 0.98913 -0.52389 0 0 0 0 0 0 9.94879 0 10.0733 0 0 0 0 0 0 A0A8C0QI00 A0A8C0QI00_CANLF Membrane spanning 4-domains A2 MS4A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MFLKRELEFLGVT;VQGNKLPCGR 2 10.2 0.98892 -0.51861 0 11.7707 0 0 0 0 0 11.2063 0 0 0 0 0 0 0 A0A8C0QI26 A0A8C0QI26_CANLF Anoctamin ANO1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] DTWMEKDRQQ;FLLKFVNSYTPI;GAVGSPEPP;HWDLTGFEEEEEAV;IEDIGYLPSEGTLLNSLSV;ISFTSDFIPRLVYLYMYSENGTMH;ITMCPLCDK;LLKKINSVLQK;LVYLYMYSENGT;MQPWRPHPPPGSAPMRGEHVE;VFQNLVMFMSDF;VIVFQNLVM;YHWDLTGFEEEEEAV 13 12.8 0.99918 -3.1821 16.6925 10.3989 11.3706 5.69282 0 0 11.0288 0 13.2439 12.9105 0 12.8048 0 12.1213 0 A0A8C0QI29 A0A8C0QI29_CANLF enoyl-CoA hydratase (EC 4.2.1.17) HADHA Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; enoyl-CoA hydratase activity [GO:0004300]; NAD+ binding [GO:0070403] DHANSANKF;LGFPPCLGGPFRFVDLYG;PEERTIEYL;VIPGHCVFASNTSAL 4 7.2 0.98889 -0.52298 0 0 0 0 9.84215 0 0 0 0 0 0 0 0 10.3854 0 A0A8C0QI35 A0A8C0QI35_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CPAAGAARDPDCER;PKKKKRRRRRRRRRRRWRAP 2 20.5 0.92008 0.10908 0 0 0 0 0 0 0 0 9.56362 0 0 0 10.1823 0 0 A0A8C0QI36 A0A8C0QI36_CANLF Pericentriolar material 1 protein C-terminal domain-containing protein PCM1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; protein localization to centrosome [GO:0071539] centrosome [GO:0005813] ATSMVTNLEETPI;DMMTDAVNENTKDEETEE;DPQQEPMEEI;EEQDASSNDNFSMYP;GHHTVPGS;ILEGDHGSPAGE;IPFLKILRW;LWSEMRRHEMLREELRQR;MAFPKPFESSSSIGAEKQ;NERSANVERLTHLIDHL;QEERKKLIEIQEKI;QLQEERKKLIEIQEKIQ;SDFSMFEAL;TDAVNENTKDEETEESEYD;VSDQEEDEESEECP 15 8.6 1.0038 -0.80421 2.2126 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QI43 A0A8C0QI43_CANLF Tr-type G domain-containing protein EEF2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746] GAGELHLE 1 1 0.9846 -0.25882 0 0 0 0 0 0 0 0 0 0 0 9.39842 0 0 0 A0A8C0QI44 A0A8C0QI44_CANLF Teneurin transmembrane protein 3 TENM3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cell projection [GO:0042995]; plasma membrane [GO:0005886] AAGRPMHCQVP;ASLTLVFERSPFLTQYHTVW;ENEAVMSPEHAM;FKYRRQTRLSEILYDSTRVSFTYDE;FPSGNVTSVLELSSNP;GENQFISQ;GVCEPATRRGLAFCAEMGLPHRGYS;IESVVECPRNCHGNGECVS;KEENDIPSCDLSGFV;LNSAFYLE;LVDCMDPDCCLQSSCQ;LVDCMDPDCCLQSSCQNQ;LVHRETDEYTRQGQN;LYGNRVKDLVHRETDEYT;NSYQIGYDGSLRIIYASGL;QTEPHVLAGTA;RNCHGNGECVSGT;SGSCTCDP;SSCQNQPYCRGLPD;SSGDEFYI;SSNPAHRY;SVARHTMQTIRSIGYYRNIYN;VLYITETDEKIN 23 10.9 0.99696 -5.4281 9.68937 0 9.90596 0 9.22292 4.93692 8.89442 12.7008 8.55063 9.53119 9.15411 7.46581 9.1062 7.83618 10.2999 A0A8C0QI46 A0A8C0QI46_CANLF Translation elongation factor EFTu-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] PIWDSIPGLQ 1 3.6 0.99028 -0.2221 0 0 10.9722 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QI50 A0A8C0QI50_CANLF EF-hand domain-containing protein KCNIP3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; catalytic activity [GO:0003824] AKEAMKVSDGSL;FDTFCPLGPALVTK;KVVCVGMN;VSARDWQMRRNGKQWLL 4 8.7 1.002 -1.4162 0 0 0 0 0 0 0 0 0 0 0 3.22586 11.9625 0 11.9397 A0A8C0QI63 A0A8C0QI63_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HYKEHLSL;LLLPARVPKP;SKFGERIPAE;VLTRQSLSQE 4 6 1.0031 -2.3499 5.29179 0 6.69446 0 0 0 0 0 10.0038 0 0 0 0 0 0 A0A8C0QI70 A0A8C0QI70_CANLF Dynein assembly factor 3 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axonemal dynein complex assembly [GO:0070286] VHLLSPDLGACVA;YKGRFQLLYVACGM 2 8.5 0.98814 -0.49016 0 0 0 0 0 0 0 8.55209 10.5858 0 0 0 0 0 0 A0A8C0QI74 A0A8C0QI74_CANLF C-X-C motif chemokine Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009]; growth factor activity [GO:0008083] AARLLLLLLLLLL;ARLLLLLLLLLLLGPA;GAARLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;PLGAARLLLLLLLLLLL;RLLLLLLL;RLLLLLLLL;RLLLLLLLLLLLGPAGRRAAGA;RNPRAPRPLGAARLLLLLLLLLLLG 12 12.7 0.97866 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 7.28549 0 A0A8C0QI80 A0A8C0QI80_CANLF Ribosome-binding protein 1 RRBP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] HSRVGAASP;SHASLRADAEKA;TDGAPNQGKKSEGA 3 2.2 1.0027 -0.86169 0 0 0 0 0 0 0 0 10.2568 0 0 0 0 0 0 A0A8C0QI86 A0A8C0QI86_CANLF Ring finger protein 130 RNF130 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HNAVAVVIYNNKSKEEPV;LIFYFIQKIRYTNARDRNQR;SGHFFHRNSLSP;TDPDFDHCAVCIESYK 4 15.8 1.0015 -0.695 13.7192 0 0 0 0 0 9.70817 0 0 6.6886 7.91528 0 0 0 0 A0A8C0QI95 A0A8C0QI95_CANLF COX assembly mitochondrial protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] KSREHGNVMRKRL 1 23.6 0.94164 0.059561 0 0 0 0 0 0 0 0 4.92001 0 0 0 0 0 0 A0A8C0QI99 A0A8C0QI99_CANLF C2H2-type domain-containing protein KLF5 Canis lupus familiaris (Dog) (Canis familiaris) IFSHQSETTAPPPAPTQA;LNQTQQPYRYL;QELDRANSLLNQTQQPYRYLIE;TEPVTIFSHQS;TGEKPYKCTWEGC 5 5.2 0.98646 -0.38763 0 9.38109 10.1653 0 0 0 0 0 8.86133 0 0 0 0 0 8.19052 A0A8C0QIA0 A0A8C0QIA0_CANLF Citrate transporter-like domain-containing protein OCA2 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] EPSEIVGEYKT;LEMELHQTS;SNQELRKMGLDFAGF 3 4.1 1.0018 -0.96416 9.75669 0 0 0 0 0 6.59128 8.65324 0 0 0 0 0 0 0 A0A8C0QIA9 A0A8C0QIA9_CANLF WD repeat domain 86 Canis lupus familiaris (Dog) (Canis familiaris) EQLRVFREHQGSV;GVSGPSPRAW;LTFPGSPT;RAPPPPRGAAPASSAT 4 5.9 1.0017 -1.2505 13.0481 0 0 10.2002 0 10.1767 0 9.31687 0 0 0 0 0 0 0 A0A8C0QIC7 A0A8C0QIC7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IAALRWGPGGPAALH;WWAPLPLLLLLLPTALRPGWA 2 10.5 0.974 0.047166 0 5.84348 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QIC9 A0A8C0QIC9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GSGAAARPRG;VLSAPRAGATHPP 2 6.1 0.99405 -0.28526 0 0 0 7.83712 0 0 0 8.04652 0 0 10.3113 0 0 0 0 A0A8C0QID0 A0A8C0QID0_CANLF Tripartite motif containing 7 TRIM7 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DEAVQEAKELLES;EVTQKRNE;FSLPGAAPGE;LEELSREVTQKRN;LRAFLVEQ;SQIQETSQKPDLEFLQ;VSLKTFVLKGLLKKFKEDL 7 15 0.98923 -0.21469 0 0 9.50072 0 0 0 7.39403 8.88399 9.62328 0 0 0 12.5775 0 0 A0A8C0QIE4 A0A8C0QIE4_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC22A16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] HRYITSIYTYRYVWHIH;LTSCHRFRRDEKSG 2 4.8 0.98976 -0.19949 0 0 0 0 10.1929 0 6.95198 0 0 0 0 0 0 0 0 A0A8C0QIE7 A0A8C0QIE7_CANLF WAS/WASL interacting protein family member 3 Canis lupus familiaris (Dog) (Canis familiaris) EQETLVRPKPL;ETLVRPKPLLLKLLKSV;KPPPPSPPP;LVRPKPLLLKLLKSV;RPKPLLLKLLK 5 6 0.99197 -0.27195 0 0 0 0 0 0 0 9.63014 0 0 0 0 0 0 0 A0A8C0QIF2 A0A8C0QIF2_CANLF ASXL transcriptional regulator 1 ASXL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DVVLEGGP;GCGAFCHDDC;GEEIDFETPGSILVNTNLRALI;GSGDGGEACGHPEPSGAP;KINGDSEALSPHGE;LVADTDEKRNWN;MCQGCGAFCHDDCIG;VESASGFS 8 6.3 1.0035 -2.2351 0 0 0 8.07521 0 6.29155 8.28142 0 11.2584 10.6914 6.89191 0 0 0 1.89898 A0A8C0QIG6 A0A8C0QIG6_CANLF Spliceosome-associated protein CWC15 homolog Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" catalytic step 2 spliceosome [GO:0071013] RNA binding [GO:0003723] DADDPLTDEEDEDEDFEEESDDDD;DLSSHTKI;EDFEEESDDDDTAAL;EEDEDEDFEEESDDDD;LDADDPLTDEEDEDEDFEEESD;LTDEEDEDEDFEEESDDDD 6 16 0.99167 0.009367 0 0 0 0 0 5.96202 7.09476 8.09666 0 5.01176 0 10.2059 0 0 0 A0A8C0QIG7 A0A8C0QIG7_CANLF Spectrin repeat containing nuclear envelope protein 2 SYNE2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nuclear outer membrane [GO:0005640] actin binding [GO:0003779] AEHLGEMNRQWHRVHGTL;ALPLQLLLLLLLL;ALPLQLLLLLLLLLACLL;CNLEKVQIMLQEKYSEDQHSTTLK;DILPIKRNPV;DKLYHQEKEENPDL;EKYLQSKEDLRLMLTELK;ELCAWLVQMENKVLQ;ESCKDLGPGDSG;HLDSLLQALITLKKKK;HLHRQWEDL;HNILHSIFTDLEDLSIIFETD;HQLSQDLLLWLAS;ILQQKHSMMLLENQ;IRAALPLQLLLLLLLLL;IRAALPLQLLLLLLLLLACLL;KATVKMEEYHDLLKSTEAWIEN;KDLDEYEEEKKCL;KEHEACFSEEASLYQ;LDLLEVLSG;LHDSDACANETECDSIQ;LLLLLLLL;LLLLLLLLL;LNTSIDLRTDVLND;LQQDVQKTK;QENKELMENEIQER;QEQADVCKDLCVFERLFLGDQLKN;RNLQFHLNKMRIFEEPPFE;RVIRAALPLQLLLLLLLL;SFELSASDTQVVPEDTLTVENKKGE;SFQNMELQDHPE;SLLKELKSQGSYLLECTKNP;TQAKELNDH;VEEQDGGLNTIALATELQN;VEHFSESDADDKMR;VGGSSSHEDDEEGPYYSALSD;VSKIKAILL;WTQVNQDIAEQLQKAQSLLQ 38 7.4 0.99658 -4.92 13.5116 10.5787 11.4411 0 11.2544 11.4396 10.7936 9.37273 10.8984 4.23756 0 12.0202 11.0197 9.84562 9.93845 A0A8C0QIH5 A0A8C0QIH5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] GPGTRGGT;PVPPYQHEEIIGKVCEL;RDSGDLVHHWVQ;SPPAVVEEKWKPQA;VRSRYSGT 5 5.7 1.0024 -1.7872 7.3156 0 0 0 10.551 10.1653 0 0 11.8555 11.8494 11.7199 0 0 0 0 A0A8C0QII3 A0A8C0QII3_CANLF EMAP like 2 EML2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTETHDLVAIHTDGN;EAALFRPQFPHPF;EQISVVSFSPD;GTLVSGGG 4 7 0.93986 0.064066 0 0 0 0 0 4.04832 0 0 0 0 0 0 0 0 0 A0A8C0QIJ5 A0A8C0QIJ5_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) NEDD4L Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] ARLPPDHR;DGVAEQAHLPPED;FNRLDLPPYE;RPSRPGAPRSPRGAPA;SEIMVTNENKREYIDLVIQWRF 5 6.2 1.0023 -0.76969 0 0 0 0 14.2819 0 0 0 0 0 8.36343 0 0 0 0 A0A8C0QIP6 A0A8C0QIP6_CANLF BTB domain-containing protein KLHL7 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463] EVELKDAEPDIIE;QVYDAAVR;VGNSALYL;VGSIVYVLAGFQ;VRAEDQVYDAAVRWLKYDEPN;YKTDEFLQ 6 11.5 1.0021 -1.4479 0 8.8614 11.2467 0 0 0 0 0 0 10.4332 0 0 9.03284 0 9.10153 A0A8C0QIQ1 A0A8C0QIQ1_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGGAAPPPPPPPGPWAPS;EYFLKVLIPSY 2 5.5 0.95808 0.051203 0 0 0 0 0 9.69002 0 0 0 0 0 0 0 0 0 A0A8C0QIQ5 A0A8C0QIQ5_CANLF USP6 N-terminal like USP6NL Canis lupus familiaris (Dog) (Canis familiaris) AKYDRGREGAEIEPWE;EFVPKWNKPSD;EFVPKWNKPSDISAIE;LAVTIPSSADTRISNVRQKMK;LRIWDIYIFE;QEIYTSFYTM;TEAAVNSQGRTNRLTKDS 7 10.8 1.0023 -1.1732 0 0 0 8.5196 11.5384 0 0 0 10.4184 10.6602 0 0 11.6828 0 0 A0A8C0QIR0 A0A8C0QIR0_CANLF Procollagen C-endopeptidase enhancer 2 Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] collagen binding [GO:0005518]; peptidase activator activity [GO:0016504] ESNYCSSN;KEGNLAIQQAGKNMS;KTPNWPDRDYPAGVTCVWHI;SSGNKMMVQMISDA;TLESNYCS 5 10.9 0.9186 0.11416 0 9.37228 0 7.2427 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QIT1 A0A8C0QIT1_CANLF ETS domain-containing protein SPI1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" EVKKVKKKLTYQ;LDLLRSGDMKDSIWWV;LSPAQPSSDEEEGERQSPP;SDEEEGERQSPP 4 17.3 0.98874 -0.30844 0 6.23377 0 0 0 0 11.0272 0 0 0 9.38368 9.43233 8.36693 0 6.67737 A0A8C0QIU6 A0A8C0QIU6_CANLF UBA domain-containing protein UBAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTFMTFNLMFREKN;PPGYSYTGLPYYTGVPSAF 2 2.9 0.98698 -0.50071 0 0 0 0 0 0 0 11.0081 0 0 0 0 11.0526 0 0 A0A8C0QIW4 A0A8C0QIW4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) DCLK2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] PAPRGVESLPEPRVLRPRT;PKLVTVIRSGVKPRKAVRILL 2 4.6 0.95157 0.049862 0 0 0 0 0 0 9.78671 0 0 0 0 0 0 0 0 A0A8C0QJ04 A0A8C0QJ04_CANLF NYN domain and retroviral integrase containing Canis lupus familiaris (Dog) (Canis familiaris) DNA integration [GO:0015074] nucleic acid binding [GO:0003676]; RNA-DNA hybrid ribonuclease activity [GO:0004523] AEKASDKAENR;EEGHKHVLIV;EVPSATTKPAAQGVPTTQKAAEGLP;GAQGGGQW;PQALHCAFL;RVSKAWLIRWSLLV;SVKDKTSPG;VLICPPHQQKEGPAMV;VSALGVCPPWKAWTPGPA;YCFYREDEWC 10 6.8 0.99342 -0.16215 0 0 0 0 0 9.33235 0 0 0 0 0 0 0 0 0 A0A8C0QJ26 A0A8C0QJ26_CANLF Homeobox protein Hox-B1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" EDGRGGTDLLGE;YHPSSYGA 2 4.6 1.0042 -1.0789 0 10.1792 0 0 0 0 0 10.1909 0 0 0 0 0 0 0 A0A8C0QJ32 A0A8C0QJ32_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) endoderm formation [GO:0001706]; negative regulation of MAPK cascade [GO:0043409] cytoplasm [GO:0005737]; nucleus [GO:0005634] MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine/threonine phosphatase activity [GO:0008330] AGTKTRSDGGR 1 2.4 0.98433 -0.25703 0 0 0 0 0 0 0 0 0 9.78282 0 0 0 0 0 A0A8C0QJ44 A0A8C0QJ44_CANLF Exocyst complex component Sec8 EXOC4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane transport [GO:0006893]; protein targeting to membrane [GO:0006612]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145] AASLSSLLL;ADLDFASCSCCHC;LDFASCSCCHC;MQTLSELA;NLLSCKMLLHCKRDELR;PQKLEQCMVSKHYLS;QEIEHALGLGPAKQ 7 7.7 1.0031 -1.3281 10.6199 0 0 0 0 0 10.6644 5.55667 8.17153 0 0 0 0 7.11114 0 A0A8C0QJ56 A0A8C0QJ56_CANLF Metalloendopeptidase (EC 3.4.24.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] VLHELMHVLGF;VLHELMHVLGFW;VMGLLCLP 3 4.6 1.0019 -1.4707 0 0 0 0 5.59541 0 10.2358 0 0 0 0 0 0 13.0527 0 A0A8C0QJ59 A0A8C0QJ59_CANLF Double PHD fingers 3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] GVAQNNCYIWMEKRHRG;LSYHYAHTHLASE;YHFTDEEMEAQFNPLKFQLEDQGDV 3 11.7 0.97875 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.7039 A0A8C0QJ74 A0A8C0QJ74_CANLF Calcium dependent secretion activator 2 CADPS2 Canis lupus familiaris (Dog) (Canis familiaris) dense core granule exocytosis [GO:1990504]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytoplasmic vesicle [GO:0031410]; presynapse [GO:0098793] GRGRARARALAPGVRPPRAPRV;MAKERNFPKF;NAKQPTDMAR;REKVNEEMYIEKLFDQFTGF 4 4.4 0.93461 0.097021 0 0 7.55405 0 0 6.83074 0 0 0 0 0 0 0 0 0 A0A8C0QJ80 A0A8C0QJ80_CANLF vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.17.4.4) VKORC1L1 Canis lupus familiaris (Dog) (Canis familiaris) vitamin K metabolic process [GO:0042373] endoplasmic reticulum membrane [GO:0005789] quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057] GGGGGGGG;GGGGGGGGK;GLLGSIFGKDGVLNQP;VLNQPNSVF 4 13.2 0.98409 -0.24246 0 0 0 0 0 0 0 0 9.67391 0 0 0 0 0 0 A0A8C0QJ88 A0A8C0QJ88_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) germ cell development [GO:0007281] CHPDSDTDDDEDEGD;FKRNTLNQPCSGSVSLQ;GGGGGGGA;GGGGGGGG;IFPLYICCNFL;KQQWLAMLRAE;LMTHQNVELFK;NVKTVCGYYTSAG;TDDDEDEGDEQQ 9 17 0.6627 0.31687 4.65575 0 0 0 9.00677 0 0 0 10.3399 0 11.597 8.88441 8.63662 0 0 A0A8C0QJ93 A0A8C0QJ93_CANLF CUGBP Elav-like family member 4 (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] GEDSSSDTHRQQ;LTYCERESALKAQSALH;VGRGRGGQ 3 8.4 1.0028 -1.0075 0 6.15062 0 0 0 0 0 0 6.73525 0 0 0 6.67849 0 0 A0A8C0QJB0 A0A8C0QJB0_CANLF Activator of transcription and developmental regulator AUTS2 AUTS2 Canis lupus familiaris (Dog) (Canis familiaris) ENPKKSSEVKVK;GVGTLPEHDSQDAGPI;TWAGQATKPG;YLRTEFHQHQHQHQ 4 5.2 0.98638 -0.45101 0 0 0 9.44748 0 0 9.79821 6.64111 0 7.71891 0 0 0 0 0 A0A8C0QJC5 A0A8C0QJC5_CANLF HYDIN/VesB/CFA65-like Ig-like domain-containing protein CFAP221 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cilium movement [GO:0003341] cilium [GO:0005929] EAFTIDPVSGIIP;GAEDEATIITLP;LVGSCAGL;LYQYWPQGQP;PGHISCYSMG;SSTSYKPQ;VLDEEFQRLTTEV;WISQFNSQPYECV 8 7.8 0.99951 -2.8984 0 9.21866 10.6839 0 8.90346 9.13983 10.3412 0 0 0 4.0408 10.942 10.7092 0 0 A0A8C0QJD0 A0A8C0QJD0_CANLF Mitochondrial ribosomal protein S9 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] FFYNCFTLSRTFLKDWILRLRHTTG 1 6.8 0.97873 0.035538 0 9.66381 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QJE0 A0A8C0QJE0_CANLF Cadherin EGF LAG seven-pass G-type receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] FPKELESSVFFSA;GPNAQIMYQIVEGNV;GPNAQIMYQIVEGNVPEVFQLDLL;GVEAVDHG;GVSSRLHLQILNNY;ITLALPLDY;PDDSATTRATL;SAKGCELLSRNRTH;TTRATLLT;VEIQVSRDELELFVEE;VLSTTKDDVFVFNIQN;VTVSDTNDHSPAFEQSEYRERV;YTCECLEDFTGE;YTMTELDYED;YVTNKSNSFPTGVIGRIP 15 6.9 0.99315 -0.053385 0 0 0 0 10.7735 0 0 0 0 0 0 0 0 0 0 A0A8C0QJF4 A0A8C0QJF4_CANLF Centrosomal protein 250 Canis lupus familiaris (Dog) (Canis familiaris) ALGQEETRKEEASTLQRALEQ;ESELTELHGT;GQTALQQQK;LIQSLMEKEQRLLV;QEECGALLQAKMDLQK;QEYSRIQK;QTALQQQK;QTALQQQKSAHEEE;RAEQRPREEVSEVEAEPS;SGSLLTCCLRLT;STLQRALEQ 11 5 1.0025 -1.7473 10.0074 8.79497 0 0 0 0 10.8353 9.44956 0 8.72093 8.41439 8.48345 9.05572 8.81657 12.4796 A0A8C0QJH1 A0A8C0QJH1_CANLF USP domain-containing protein USP38 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] cysteine-type deubiquitinase activity [GO:0004843] ESAELWLDGAQC;RVFFEASRPPWF 2 2.4 0.98552 -0.23551 0 0 0 0 0 0 0 0 0 0 0 5.02112 0 0 0 A0A8C0QJH5 A0A8C0QJH5_CANLF ADAM metallopeptidase domain 21 LOC119869006 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] FKQCYSNLCCHNDC;GVRLAEGRDTM;LEDIQCGRLQCSNVTHLPRLQEHVG;LHRGKGVQMPGWLSYSLHFGG;RSQCIMNNYFAL;YNQRDPNVLNNYHPT 6 13.1 0.9822 -0.25066 0 9.62618 8.92612 9.82483 0 0 5.13254 0 12.6128 0 0 0 0 0 7.07007 A0A8C0QJK0 A0A8C0QJK0_CANLF Rhodanese domain-containing protein CEP41 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; protein transport [GO:0015031] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737] AGPPSPPGPPSPV;CPFLLLDVRDRDSYQ;GLITGSLPASCQQALPP;LSGGLKVLAQKF;QTLPAGPPSPPGPPSPV;SKAPGTRSGQTLPA;TPEDLKKIEYYLEED 7 23.9 0.93359 0.099644 0 10.3697 0 0 0 0 8.58909 0 0 0 8.63717 0 0 7.63488 8.90698 A0A8C0QJM6 A0A8C0QJM6_CANLF Shisa family member 7 Canis lupus familiaris (Dog) (Canis familiaris) LDSMHNYLH;PAGAPAAP;RGAGGGAG 3 4.4 0.99017 -0.26657 0 0 0 0 0 0 0 0 0 0 0 8.1152 0 0 0 A0A8C0QJN7 A0A8C0QJN7_CANLF Collagen IV NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] AAKGGCAG;APGPKGEPGFQGLP;EAGLPGQPGPTGPAGQ;EKGERGYPGAPGLRGE;GVSGPPGVPGQAQVQE;KGPGLPGPEG;PGAPGPKGE;SGYPGNPGLPGIPGQDGPPGPPG;VGGMGLPG 9 6.8 0.99639 -0.58178 0 0 0 0 8.95989 0 0 0 0 0 0 0 0 0 0 A0A8C0QJQ5 A0A8C0QJQ5_CANLF Interleukin-5 (Eosinophil differentiation factor) IL5 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-5 receptor binding [GO:0005137] TKFLDYLQ 1 6.1 0.99276 -0.16875 0 0 9.63512 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QJQ6 A0A8C0QJQ6_CANLF Immunoglobulin subtype domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of adaptive immune response [GO:0002819] transmembrane signaling receptor activity [GO:0004888] PDIRLQGHFFSVSV;TPSDSGTYQCC 2 13.8 0.92908 0.096455 0 0 0 0 1.96029 0 0 0 0 0 0 6.30499 0 0 0 A0A8C0QJR1 A0A8C0QJR1_CANLF GDNF/GAS1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] SLVENNFQFEDCLCTDNI;VIAAHICQQMEHCT 2 6.1 0.91635 0.10927 0 0 0 0 9.32231 0 0 0 0 0 7.45154 0 0 0 0 A0A8C0QJT0 A0A8C0QJT0_CANLF FBA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ADEPAAPGEPPS;PAAPGEPPSPPPPPSPPSPAAPEP;QPDITMDWYED;VIAQHHVAPRTSG 4 19.3 0.99198 -0.14075 0 0 0 5.78178 10.2446 0 0 0 0 0 7.28873 0 0 0 0 A0A8C0QJT5 A0A8C0QJT5_CANLF Tensin 3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; focal adhesion [GO:0005925] phosphoprotein phosphatase activity [GO:0004721] GVDPVYER;GVGPTPHLPDAQRPPPG;LDPQDRKWI;SGGTQSWLQ;VIFCALDP 5 2.8 1.0021 -2.6182 0 12.2093 0 0 0 0 7.35191 0 0 0 0 0 10.3171 10.8135 0 A0A8C0QJT8 A0A8C0QJT8_CANLF POU domain protein Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAGGGGGG;GGGGGGGA;GGGGGGGG;LVHPGLVRGD;PPGPGGGGG 5 9.2 1.0033 -1.0566 0 0 7.3137 0 0 8.31379 0 0 0 0 0 0 0 0 0 A0A8C0QJU3 A0A8C0QJU3_CANLF Cellular tumor antigen p53 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262] centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] VPHVWLLTESAARPAV;VYYMHVRGREN 2 4.5 0.96135 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 10.307 0 A0A8C0QJU7 A0A8C0QJU7_CANLF Receptor tyrosine kinase like orphan receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ARSNPLILMRLQLPKCEALPLPE;EALPLPESPD;KASASTPQRRQ;NVSNARYGGPKQKAQPFPQP;PVGWRALPL;PVPAYGAYLSNFYPVQ 6 8.5 1.0001 -0.61515 0 8.61938 9.59154 0 0 0 0 10.1821 10.3664 0 0 0 0 9.946 7.48115 A0A8C0QJW7 A0A8C0QJW7_CANLF Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 PCMTD2 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] AAGCGCGC;AVRSLQDLARIAIRATIKKV;DDNSCEDLEEEQRE;GAPRSCRSRPGGPVS;GSATSPVP;GVHGGGAGA;PGSATSPV;QKLDFFIRTSDSFDKFDFCEPSFVT;VLCSAPGL 9 13.1 0.99736 -3.4888 8.70929 7.4937 11.6942 0 7.65507 0 0 0 9.41331 0 0 8.68947 10.6598 0 0 A0A8C0QJY1 A0A8C0QJY1_CANLF Bardet-Biedl syndrome 9 Canis lupus familiaris (Dog) (Canis familiaris) BBSome [GO:0034464] DGTYKQVIALADAVEE;DPILQVEVGKFVSGT;VDSVSVTLQ;VLGEKEEF;WSTVLGEKEEFDQ 5 6.1 1.0011 -0.9344 0 0 0 7.37521 0 0 9.74631 0 0 0 0 0 0 0 0 A0A8C0QJY9 A0A8C0QJY9_CANLF ADAM metallopeptidase domain 18 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] DPDIPLLAENY;ECDCGSQEECQFKKC;EECDCGSQEECQF;EPNEECDCGSQEECQ;HSESSYFKMHCHYQGYVA;NEMRKSCKRE 6 8.3 0.9844 -0.24183 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2407 0 A0A8C0QK15 A0A8C0QK15_CANLF Glycosyltransferase 2-like domain-containing protein B3GNTL1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] GVTGPRRWA;GVVRVDQSLVLYRYHPD;PRLPPSLGV 3 7.3 0.99036 -0.53586 0 9.19195 0 0 0 6.00601 0 0 0 0 0 0 0 0 0 A0A8C0QK18 A0A8C0QK18_CANLF Protein disulfide-isomerase (EC 5.3.4.1) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] protein disulfide isomerase activity [GO:0003756] EEEEDDDEEEEEDDL;EKFQSKYEPR;GPREKYGIVD;LKVSSGKLVV;LVVMQPEKF;PDGDSSNKEDAIEDEEEEDDDEE;VGHRRSAND 7 12.1 1.003 -1.706 0 9.82983 0 0 4.83825 0 0 0 0 0 6.33814 0 12.4293 3.47794 0 A0A8C0QK49 A0A8C0QK49_CANLF Cellular tumor antigen p53 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262] centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALSPQFPD;HLPPAEPD;LRMHRGRGEVRYEHATGTQE;QSPAPGPRAKP;VYYMHVRGREN 5 8.3 1.0019 -1.8167 0 0 0 0 7.58331 0 0 0 0 0 7.88917 0 0 0 2.45875 A0A8C0QK59 A0A8C0QK59_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) AAKKIFLPTLKKK;AAKKIFLPTLKKKKKKKVA;AAKKIFLPTLKKKKKKKVARSLPPI;AKKIFLPTLKKKKKKKVA;ANKLGNLEEMDAF;GAAKKIFLPTLKKKKK;KIFLPTLKKKKKKKV;KKKKKKKV;KKKKKKKVA;MDAFLESHKL;MNEKGEITTNT;TLKKKKKKKVARSLP 12 8.5 1.0015 -0.74455 0 0 10.815 4.05172 0 0 7.00854 6.47202 7.70688 0 0 0 5.11345 5.77957 0 A0A8C0QK63 A0A8C0QK63_CANLF Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (PHS II) (Prostaglandin H2 synthase 2) (Prostaglandin-endoperoxide synthase 2) PTGS2 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516]; response to oxidative stress [GO:0006979] endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640] dioxygenase activity [GO:0051213]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] DIDAMELYPA;DQEYNFQQFIYNN;PDSKEIVEKFLLRRK;SPGRERLRLRLRRRLRLRRRLCH;YNFQQFIYNNSILLEH 5 9.9 0.98607 -0.45308 0 0 0 0 0 5.06828 0 0 0 0 0 0 7.33324 9.30788 0 A0A8C0QK80 A0A8C0QK80_CANLF Focal adhesion kinase 1 (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK) PTK2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; regulation of biological quality [GO:0065008]; regulation of cellular component organization [GO:0051128]; regulation of multicellular organismal process [GO:0051239]; signal complex assembly [GO:0007172] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] APEPLTVTAPS;IYPGQASLLDQTDSWNHR;LTAAHALA;PTHLMEERLIRQQQEM;SVELAIGPE;WIISVELAIGPEE 6 6.9 0.98543 -0.43912 7.21684 9.92385 9.62286 0 0 0 0 8.48289 0 0 0 0 7.49953 10.1401 0 A0A8C0QKA0 A0A8C0QKA0_CANLF Costars domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Rho protein signal transduction [GO:0035025] actin binding [GO:0003779] AKRAEEHIYREIM;LSPPPHTHTHTH 2 5.8 0.98922 -0.19961 0 0 0 0 12.3664 0 0 0 9.74034 0 0 0 0 0 0 A0A8C0QKB1 A0A8C0QKB1_CANLF Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1) LOC119879505 Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006] pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739] EICARIMEGISENLVLEYS;VINSAAKTYYMSGGLQ 2 10.4 0.97571 0.044286 0 0 9.69505 7.19476 0 0 0 0 0 0 0 0 0 0 10.3488 A0A8C0QKC7 A0A8C0QKC7_CANLF DPF1-3 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] GVAQNNCYIWMEKRHRG;LMLLGDQFYKEAIE;LSYHYAHTHLASE 3 11.6 0.94269 0.061052 0 0 0 0 0 0 0 0 8.92469 0 0 0 0 0 0 A0A8C0QKC9 A0A8C0QKC9_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) circadian rhythm [GO:0007623]; DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] MMVLNPTLTEVSEDL;SALPHKLRIKAK 2 6.4 0.91667 0.11323 0 0 0 1.79934 0 0 0 0 0 0 0 0 0 0 12.8059 A0A8C0QKF4 A0A8C0QKF4_CANLF Zinc finger protein 330 (Nucleolar autoantigen 36) ZNF330 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] zinc ion binding [GO:0008270] DEAEDDEDED;EEEDEDEAEDDEDEDDEVGKDSDA;EIQKKKKKKRRLVFVKR;INEIQKKKKKKRRLVFVKRARGRAR;IQKKKKKKRRLV;IQKKKKKKRRLVFVKRARGRARRRT;KKKKRRLVFVKR;NEIQKKKKKKRRLVFV;RLLSARVRTGAADVGG;RPRAVPCPPAP;SYQFVHSV;YGDSSYHDEEEDEDEAEDDEDEDD;YHDEEEDEDEAEDDEDEDD 13 18.5 1.0021 -0.6815 7.27268 8.49037 0 0 0 8.82871 0 0 0 7.40148 0 6.9629 8.28142 0 6.51934 A0A8C0QKH2 A0A8C0QKH2_CANLF P-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DVVKTNAGF;EQVVQEYLELIGR;GDVVKTNAGF;HTWGMFSR;IDCQFMLGPAI;IIGMMEFSLF;ITPVLDEGAEKVMAYIPD;LENNKFQVSAYFPR;LQVALITEIDLILGEAY;LSAQDSLESKD;PVNYKGFP;SAQDSLESKD;SAQDSLESKDPG;TTLELMLSVLLLMVF;TTTPTLPDTTAP;VLSAQDSLESKD;VLSAQDSLESKDPG 17 8.7 0 17.045 13.7587 9.84405 12.4486 12.9564 13.269 13.3401 13.3706 13.4267 13.368 12.5238 9.25463 12.5791 9.5706 12.0585 9.86784 A0A8C0QKN6 A0A8C0QKN6_CANLF Src homology 2 domain containing transforming protein D SHD Canis lupus familiaris (Dog) (Canis familiaris) phosphotyrosine residue binding [GO:0001784] GGRRPPPQP;YEEQDQDPGD 2 6.4 1.002 -1.4157 0 0 0 7.17513 0 0 0 3.18832 6.07215 0 0 0 0 0 0 A0A8C0QKR9 A0A8C0QKR9_CANLF Tubulin-specific chaperone D TBCD Canis lupus familiaris (Dog) (Canis familiaris) post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021] beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096] IAMDGTLQALAQ;IDHLVAMKINHWDG;LDGGQADPVKQ;LGLTFLKPRV;QEQPHLLDPH;TADCDSDG;TLLRKLGVKLVQRL;VGGLTESTVRYS 8 8.3 0.99903 -2.9594 0 0 0 0 0 0 0 10.3986 0 8.71651 0 2.27816 11.3599 8.1631 9.32787 A0A8C0QKT2 A0A8C0QKT2_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] metal ion binding [GO:0046872] DIFGDPLNLTT;DSYMTSMDLSYPRNLQ;FISNMMRNFYEKCFECS;GVTVVQNH;KACKNKFFCVAE;NEQNGSFSLACTLNGH;NHGSRKNA;RWRRALKTKEEVEEE;VLSSLLHQDSSTNQTWLLVTSP 9 10.7 1.0034 -1.067 0 9.11239 0 8.53485 0 11.6015 5.14033 9.40682 5.66826 0 0 0 3.58868 0 0 A0A8C0QKU4 A0A8C0QKU4_CANLF Poly(ADP-ribose) polymerase family member 12 PARP12 Canis lupus familiaris (Dog) (Canis familiaris) protein auto-ADP-ribosylation [GO:0070213] metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein ADP-ribosyltransferase activity [GO:1990404] KVHFHLPYRW;SSDEYQKVWNLFNRTLPF;SVSPNTANQEES;SVSPNTANQEESD;SVSPNTANQEESDEICLY;VLCAAGGA;VTQVLCAAGGALELE 7 8.7 0.98977 -0.52719 13.5124 13.7144 13.5383 12.8487 12.9549 12.9536 13.6542 13.7349 13.6937 13.929 13.726 14.1031 13.6684 13.6209 13.4371 A0A8C0QKV6 A0A8C0QKV6_CANLF Ciliogenesis and planar polarity effector 1 CPLANE1 Canis lupus familiaris (Dog) (Canis familiaris) DKTITELHS;DLEVEFDSCMVEH;EETNEGNHFPNNL;EILRGSHLPVKENEDCSV;GGGGGGGSL;HIRDKLSYNCRQYQK;IEEEDVNLLFGSVQEV;ISQEQHCLSPRRE;ISQEQHCLSPRRENKYGHNIPTN;KDQQIISPISE;LIVLWRVLYKKTLW;LNYCKGGVAFFRP;NKEAPSDRETSEAEFSVT;PQPVGEYTRE;PRRAAREALGL;QEKWSWNSSFKICP;RLYLYVSGNGKR;SEAWSVEEKRNT;VGQWSQIIPDEAVHLPSKED;VGSPVINPTRGS;VLSAAVPV;VLTTSSNDVWLA 22 8.4 0.99894 -3.245 0 10.752 10.8981 12.6193 5.68916 7.85393 9.80085 9.41185 10.9816 0 8.9718 0 10.6209 0 0 A0A8C0QKV8 A0A8C0QKV8_CANLF Gastric inhibitory polypeptide receptor GIPR Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] gastric inhibitory peptide receptor activity [GO:0016519] LLSSWRPLLGRAET 1 3.6 0.93592 0.060932 0 0 0 0 0 0 0 0 0 8.6643 0 0 0 0 0 A0A8C0QKW6 A0A8C0QKW6_CANLF DUF4476 domain-containing protein PROSER1 Canis lupus familiaris (Dog) (Canis familiaris) AHSTTSAPVPSVF;ASPVKAGNHPSAS;EVVNILNCFTFSK;LRYFSWAEPQLKAMKALQH;VTATASGLNMANTV 5 8.2 0.98772 -0.46883 0 0 10.23 0 0 0 9.66743 0 0 0 0 0 9.76876 0 0 A0A8C0QKW9 A0A8C0QKW9_CANLF "C-1-tetrahydrofolate synthase, cytoplasmic (EC 1.5.1.5) (EC 3.5.4.9) (EC 6.3.4.3)" MTHFD1 Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrofolate interconversion [GO:0035999] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] GADIGMEKFFNIKCRYSGL;GVPVVVAV;PLGEGKSTTTIGLV;TKPNGRKV;VGAPMHDL 5 6.7 1.0027 -1.7635 8.59526 13.1171 0 0 0 0 0 13.1759 13.0026 0 13.0212 0 9.06735 0 16.5002 A0A8C0QKX8 A0A8C0QKX8_CANLF TOG domain-containing protein CEP104 Canis lupus familiaris (Dog) (Canis familiaris) ALEGTCTGKSD;DMYQDPEVAQIIRKL;EDYDLAKEKKQ;EQFRNQVYEQLQLHSLVDAEPMR;KVEFYISESLPEYFVP;RLGRYEVEKRCAVEKEDYDL;SDSDVSEA 7 11.3 1.0018 -1.4695 10.1489 0 0 0 8.95832 8.69059 0 0 0 0 0 9.41608 0 0 8.43279 A0A8C0QKY3 A0A8C0QKY3_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] FVNSQEWTL;GGGGGGGG;SCARASAAAAS 3 6.3 0.98359 -0.24209 0 0 0 0 0 0 0 0 0 0 0 0 0 9.63218 0 A0A8C0QKY5 A0A8C0QKY5_CANLF "Centrobin, centriole duplication and spindle assembly protein" CNTROB Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; regulation of cilium assembly [GO:1902017] QETVTHLEQ;REEDSFDSDSTATLL;RKGGHSGP;VGLENNLKKQD 4 4.8 0.98529 -0.23564 0 0 0 0 0 0 0 0 0 0 0 0 0 9.83338 0 A0A8C0QL04 A0A8C0QL04_CANLF Protein kinase domain-containing protein STK31 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] FHEIYREQEE;FYDWKCDKREE;LHKADIIHGSLHQN;SVFHEIYREQEEYEKLN 4 4.4 0.98775 -0.48094 0 0 0 0 0 12.0109 0 0 0 0 0 0 10.8757 0 0 A0A8C0QL05 A0A8C0QL05_CANLF Sugar phosphate transporter domain-containing protein SLC35D1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; membrane [GO:0016020] antiporter activity [GO:0015297]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; UDP-N-acetylgalactosamine transmembrane transporter activity [GO:0005463]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462] GCIKNILITYIGMVFGGDYIFTWTN;SEEQLSKQSEASN 2 10.7 0.99621 -0.09502 0 0 0 0 0 0 0 0 0 0 0 9.46041 0 8.57543 0 A0A8C0QL14 A0A8C0QL14_CANLF DUF1731 domain-containing protein SDR39U1 Canis lupus familiaris (Dog) (Canis familiaris) VVQAVFGRERA 1 5.2 0.98988 -0.26576 0 0 0 0 0 0 0 0 0 0 0 0 0 13.2207 0 A0A8C0QL21 A0A8C0QL21_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LPVDDKFPVLSLDCAVEFA;VPVEAGMMFWAAPRPSRH 2 15 0.96998 0.048313 0 0 0 6.40502 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QL34 A0A8C0QL34_CANLF PIPK domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] ATWHFARRASQA;LQSYRFIKKL 2 3.4 0.98518 -0.25922 0 0 0 0 0 0 0 9.63822 0 0 0 0 0 0 0 A0A8C0QL40 A0A8C0QL40_CANLF PHD-type domain-containing protein PHF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] GDPVRVLARRVR;GVGYLSRGDPVRVLARRVRP;LPTAQAGI;TDGLLYLGTIKK;TPKGERSSKLLSALNSHKDR 5 10.1 1.0026 -0.76077 12.9673 0 0 0 0 8.74335 8.68954 0 10.1404 0 0 7.55528 0 0 0 A0A8C0QL48 A0A8C0QL48_CANLF SSD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAMDPEDDPL;GAAGAGGG;HVLLLLPVLLSILGIVCLV;IVSCCWLAVLF;LNVEEEPVSLELG;MLLAFISSSCIAALV;RGWKFDFSFYAAAKEQQ;RNRRDLADFTSETLQ;TAGKATFFTSL;VLLLLPVLLSILGIVCL;WSTLGWAF 11 8.1 1.0027 -1.0077 0 4.81987 0 0 3.90824 0 6.50077 9.97513 10.2634 0 0 10.2077 12.5017 0 0 A0A8C0QL93 A0A8C0QL93_CANLF Membrane palmitoylated protein 6 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] GVPSCCCT;NLELVNEILEDITP;RRRRRRRPEPGRS;SGGGAEAA 4 5.6 0.98986 -0.26592 0 0 0 0 0 0 0 8.12309 0 0 0 0 0 0 0 A0A8C0QL96 A0A8C0QL96_CANLF Synaptotagmin-17 (Synaptotagmin XVII) Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; presynapse [GO:0098793] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905] SLVCTVFGHNM 1 6.5 0.97819 0.035491 0 0 0 0 0 0 7.23189 0 0 0 0 9.71044 0 0 0 A0A8C0QLB5 A0A8C0QLB5_CANLF Rho guanine nucleotide exchange factor 28 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] ESLCHENS;LVERILQYTKERSEEHQDLC;QAGDARPSPE;RITKYPVLVE;SVCDKTLLGKESSQCSN;VIYSSFRDI;VTQRITKYPVLVERI 7 4.7 0.9962 -0.09376 0 0 0 0 0 0 10.2992 0 0 0 0 0 0 0 0 A0A8C0QLE2 A0A8C0QLE2_CANLF INTS6/SAGE1/DDX26B/CT45 C-terminal domain-containing protein INTS6 Canis lupus familiaris (Dog) (Canis familiaris) DEADEFVAGPQNKHK;ETFMKAGWKENH;LDEIHRRANQ;LTQFILERKSPQ;MNELKNLQAEGLT;RLPGTMSVESEQLTGVPLDDSAITP;VQDELHLPL 7 11.3 0.99458 -0.12946 9.55513 9.44137 0 0 0 0 0 10.898 10.9586 8.76388 7.62439 0 0 10.2009 0 A0A8C0QLG1 A0A8C0QLG1_CANLF EVA1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EELERAQRLEERE;LEPDDDDDDEDTVTRL 2 10.3 0.9616 0.049233 0 0 0 0 0 3.59658 0 0 0 0 0 0 0 0 0 A0A8C0QLG8 A0A8C0QLG8_CANLF phosphatidylinositol-3-phosphatase (EC 3.1.3.64) (Phosphatidylinositol-3-phosphate phosphatase) MTMR7 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737] phosphatidylinositol phosphate phosphatase activity [GO:0052866] IDQFIECVWQL;KFWSGMYNRFEKGLQ;SLQKMLEVCELQ;SPVIDQFIECVW;SSDLDLSANSDQESGVEDLS;VIFVENAPDTRKETWIL;VMRSSLQKMLEVCELQ 7 12.5 0.99766 -0.60042 0 12.5653 9.80657 0 11.7984 12.0872 0 0 9.87804 0 0 0 8.47492 13.1438 0 A0A8C0QLI8 A0A8C0QLI8_CANLF Interleukin 18 receptor accessory protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] hydrolase activity [GO:0016787] PSLNCQSDAQSPEVT;TETTGRSSQPREWS 2 4.8 0.9823 -0.25044 0 0 0 0 8.62363 0 0 0 0 0 0 0 0 0 0 A0A8C0QLK4 A0A8C0QLK4_CANLF P-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DINVPTCFF;ETEHTAFRRDMNWTMWGMFAR;FAQQYLQLSFR;GVSKGRCFCVCAKII;IPYDVQHVDIDY;TAFRRDMNWTMWGMF 6 4.9 0.95181 0.053904 0 0 0 8.5203 9.07556 0 0 0 0 0 9.16932 0 0 0 0 A0A8C0QLL5 A0A8C0QLL5_CANLF "Arachidonate 12-lipoxygenase, 12R type" Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440] cytoplasm [GO:0005737] "iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" AMMRQLPMCH;GNMMPIAIQLSQTP;LRGLVDCKQSW;QIPDKFPV;RRNPNRPEWNGY 5 7.9 1.0025 -0.89984 0 0 0 9.58729 8.35213 0 0 6.65177 6.91767 8.97054 0 0 4.71177 9.42484 0 A0A8C0QLM2 A0A8C0QLM2_CANLF Transmembrane protein 150B TMEM150B Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] autophagosome membrane [GO:0000421]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886] AAWICIIRYHQ;LLFMLFGLFAVDFSC;TLCLQPGPSLS;VILHHWPLRSAS;WFNQVILWTGLLC 5 26.5 0.98705 -0.33611 0 0 0 8.85072 4.4274 0 0 0 5.56432 12.4108 0 0 0 0 0 A0A8C0QLM8 A0A8C0QLM8_CANLF CutA divalent cation tolerance homolog CUTA Canis lupus familiaris (Dog) (Canis familiaris) response to metal ion [GO:0010038] membrane [GO:0016020] RFSYHVGAAQAALL 1 7.2 0.94154 0.070977 0 0 0 0 0 0 0 8.33718 0 0 0 0 0 0 0 A0A8C0QLN5 A0A8C0QLN5_CANLF Cell division cycle 40 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013] ESQLNEPSVRGRG;LRVWEWDIPVDFKYIAEPSMHS 2 5.1 0.99521 -0.15836 0 0 0 0 0 0 0 0 0 0 0 0 10.0553 15.1273 0 A0A8C0QLP0 A0A8C0QLP0_CANLF Cytohesin Ubiquitin Protein Inducing domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EARDSESAQLHIPP;GGGEEGEEG;GGRGGGGG 3 4.4 0.99543 -0.19041 0 0 0 0 8.44083 0 11.004 0 0 0 0 0 0 0 0 A0A8C0QLR5 A0A8C0QLR5_CANLF XK-related protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ENIVLLLLATD;GEGGGGSGG;GGEFTALG;GGRGGGGG;ILRPGLSRSFVG;RPGEGAGAASPLQ;SGGRGGGG;YFTTGQLLWGWLALALLLPGCLVQV 8 11.1 0.99717 -3.6248 0 0 0 0 8.93629 0 0 0 8.31442 10.2432 9.91664 9.89067 0 10.2203 11.711 A0A8C0QLS7 A0A8C0QLS7_CANLF AB hydrolase-1 domain-containing protein ABHD1 Canis lupus familiaris (Dog) (Canis familiaris) PVLCLNAADDPFSP;WTTFTEVTWPFRP 2 5.9 0.9402 0.059608 0 0 0 0 0 0 0 0 0 0 0 0 0 4.97678 0 A0A8C0QLT7 A0A8C0QLT7_CANLF Beta-hexosaminidase (EC 3.2.1.52) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] cortical granule [GO:0060473]; lysosome [GO:0005764] beta-N-acetylhexosaminidase activity [GO:0004563] ILETLDAMAFNKF;RSAGPSCALLQEAFR;VTSDESYS;YSLSHVYTPTDV;YVQKVLDIA 5 11.7 0.95008 0.053907 0 0 0 0 0 8.58676 0 0 0 0 0 0 0 0 0 A0A8C0QLV8 A0A8C0QLV8_CANLF Ankyrin repeat domain 53 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cytokinesis [GO:1902412] EADFKEWLRCKQLL;FLKDAMWRRDKKD;LTEYQKEH;MAKMNHFVFCRTCEMMAHHYD;SFYPSPEA;VHPDPSPDHDFRSF 6 16.9 0.97425 0.047166 0 0 7.08353 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QLW0 A0A8C0QLW0_CANLF Tetratricopeptide repeat domain 34 Canis lupus familiaris (Dog) (Canis familiaris) GHCHARALASCGRGPAG;PVLVRLALLQLRR;VLRVDVGDRD 3 3.9 1.004 -0.81012 0 0 0 4.6241 0 6.99424 0 0 0 0 0 13.2282 6.77255 0 0 A0A8C0QLX2 A0A8C0QLX2_CANLF Nuclear prelamin A recognition factor NARF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ADCVLTSGEIA;QENASVGVPSLAQDHTEKG;SDCLACDSCVTAEEG;VTAEEGLQVSQQNVK 4 11.8 0.99065 -0.51533 0 0 0 0 0 9.52254 0 0 0 0 0 9.84775 9.92502 0 0 A0A8C0QM00 A0A8C0QM00_CANLF Y-box-binding protein 1 (Y-box transcription factor) Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] messenger ribonucleoprotein complex [GO:1990124]; nucleus [GO:0005634] nucleic acid binding [GO:0003676] GIEEDKENQGDETQGQQ 1 4.4 0.99241 -0.050613 0 0 0 0 0 0 0 0 0 0 0 0 0 9.1397 0 A0A8C0QM13 A0A8C0QM13_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G5 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] CLKRNLRSYNPHYQY;PGSPHPRNPAAWTE 2 15.3 0.91987 0.11475 0 0 0 0 0 0 0 0 0 0 0 0 5.12536 9.33782 0 A0A8C0QM30 A0A8C0QM30_CANLF Pleckstrin homology and RhoGEF domain containing G3 PLEKHG3 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AMEEPSGPEASAEN;AMEEPSGPEASAENG;EAGAPSGGT;ESTEDLKALSSE;HHIKRLIL;KPVQRILK;LSPFDAEPFSW;QEEQEEEEEEEE;QQAKFFRD;SPGSDARMPVSASLRQDGS;VLEGTFRVH 11 8.1 0.99893 -2.9699 13.6024 15.4711 13.559 14.4845 13.1174 0 9.62079 14.0716 15.1809 13.3204 13.5521 15.4174 15.4839 15.4731 0 A0A8C0QM54 A0A8C0QM54_CANLF Chloride channel protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated chloride channel activity [GO:0005247] ALCCCCRWCCCC;CCCCRWCCCCG;CCCRWCCCCGE;DIHVGLRGVP;DLLQQMLERRYPYP;GALCCCCRWCCCC;GALCCCCRWCCCCGE;GTFSPVTL;IVRLRTLLCKVF;SLRKIQFNFPYFRSDRDK 10 9.1 1.0029 -1.6278 0 0 9.78298 6.24861 4.69036 6.6271 0 0 10.6793 0 8.21602 2.51167 6.13965 0 0 A0A8C0QM64 A0A8C0QM64_CANLF Myogenic factor 6 MYF6 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] protein dimerization activity [GO:0046983] AGGGGGVL;GGGEGGGVPG;TDRRKAATLRERRRLKK 3 10 0.98625 -0.42848 4.4272 0 13.7949 0 9.49865 0 0 0 0 14.0931 14.1619 14.0489 14.0681 14.1662 14.1356 A0A8C0QM78 A0A8C0QM78_CANLF RNA helicase (EC 3.6.4.13) RIGI Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] cytoplasm [GO:0005737] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ESRTTDRFK;KPKSFGHFEKR;TSENISVEQIVEN 3 3.6 1.0027 -1.3532 0 6.81237 0 0 0 0 0 0 10.8345 0 0 0 0 0 0 A0A8C0QM92 A0A8C0QM92_CANLF Tumor suppressor candidate 3 TUSC3 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] EDRRRKRQ;MWNHIRGPPYAHKNPHNGQVSYIH;SGEDRRRKRQANEEYQI;SSCCFSAS 4 14 0.97369 0.041303 0 0 0 8.72874 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QM97 A0A8C0QM97_CANLF Insulin-induced gene protein Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] ASAKVDFDNNIQLS;LPWVHYHASL 2 10 0.99877 -0.61146 0 0 0 0 0 0 10.5258 0 0 0 0 0 0 0 0 A0A8C0QMD4 A0A8C0QMD4_CANLF Oxysterol-binding protein OSBPL3 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] LEEGNIEEAEIQKQRIEQL;SLDNLSNDLDNERQT;WGKSMEIVPIGTTHVTL 3 6.7 0.99445 -0.13227 0 11.2033 8.76374 8.25772 0 0 0 0 0 0 0 0 0 0 9.64198 A0A8C0QMG2 A0A8C0QMG2_CANLF Solute carrier family 13 member 1 SLC13A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] solute:sodium symporter activity [GO:0015370] FLLIVLPPLV;GLGVNIVGVAVVMLG;LLIVLPPLVLLPLPIIVR;LVLLPLPIIVR;VGGGFALADGCEESGL;VYRRFLLIVLPPLVLLPLPIIVR;YILVYRRFLLIVLPPLVL 7 10.3 1.0013 -0.6942 0 0 0 0 0 0 12.7366 0 5.73514 0 0 0 0 8.89845 6.81147 A0A8C0QMK2 A0A8C0QMK2_CANLF "Polycystin 1 like 1, transient receptor potential channel interacting" Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; membrane [GO:0016020] AAASSGFGG;GEGLPESRRTSRCGGFTFTPAG;TDIDITFLA;YACLTALVTAAGQE 4 2.4 0.92366 0.10876 0 7.98413 0 0 0 0 0 0 0 0 0 7.48494 8.00731 0 0 A0A8C0QMP6 A0A8C0QMP6_CANLF Ras like without CAAX 2 RIT2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of neuron projection development [GO:0010976]; Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DAYKTQVRIDNEP 1 8.3 0.94014 0.059797 0 8.98604 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QMQ3 A0A8C0QMQ3_CANLF CCR4-NOT transcription complex subunit 2 CNOT2 Canis lupus familiaris (Dog) (Canis familiaris) GIPSRTNSMSSSGL;SDYHDENMYYSQSS;VGTGAGAG 3 6.1 1.0039 -1.1044 0 0 0 0 9.81625 0 0 0 0 0 0 0 0 0 0 A0A8C0QMR7 A0A8C0QMR7_CANLF Albumin ALB Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] lipid binding [GO:0008289]; metal ion binding [GO:0046872] AHRYNDLGEEHFRGLVL;AYKSEIAH;AYKSEIAHR;AYKSEIAHRY;AYKSEIAHRYN;AYKSEIAHRYND;AYKSEIAHRYNDL;AYKSEIAHRYNDLG;AYKSEIAHRYNDLGEEHFRGLVL;DLGEEHFRGLVL;DLPSLAAD;DLPSLAADFVEDK;EAYKSEIA;EAYKSEIAH;EAYKSEIAHR;EAYKSEIAHRY;EAYKSEIAHRYN;EAYKSEIAHRYND;EAYKSEIAHRYNDL;EAYKSEIAHRYNDLG;EAYKSEIAHRYNDLGE;EAYKSEIAHRYNDLGEE;EAYKSEIAHRYNDLGEEH;EAYKSEIAHRYNDLGEEHF;EAYKSEIAHRYNDLGEEHFRG;EAYKSEIAHRYNDLGEEHFRGL;EAYKSEIAHRYNDLGEEHFRGLVL;EEHFRGLVL;EHFRGLVL;EIAHRYNDLGEEHFRGLVL;GEEHFRGLVL;HRYNDLGEEHFRGLVL;IAHRYNDLGEEHFRGLVL;KSEIAHRYN;LGEEHFRGLVL;LPSLAADF;NDLGEEHF;NDLGEEHFRG;NDLGEEHFRGLVL;NDLGEEHFRGLVLV;NDLGEEHFRGLVLVA;RDELPGDLPSLAAD;RYNDLGEEHFRGLVL;SEIAHRYNDLGEEHF;SEIAHRYNDLGEEHFR;SEIAHRYNDLGEEHFRGLVL;SVARLSQRFPKAD;SVARLSQRFPKADF;TVASLRDKYG;VAFSQYLQ;VAFSQYLQQ;VIRESHERVKNHC;VIRESHERVKNHCDLHEKLGDAYFH;YKSEIAHR;YKSEIAHRY;YKSEIAHRYNDL;YKSEIAHRYNDLG;YKSEIAHRYNDLGEEHFRGLVL;YNDLGEEHFRGLVL 59 16.9 0.98659 -0.23522 0 0 0 0 10.3964 0 0 0 0 8.83333 0 0 0 0 0 A0A8C0QMS0 A0A8C0QMS0_CANLF "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain)" SLC2A1 Canis lupus familiaris (Dog) (Canis familiaris) photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] glucose transmembrane transporter activity [GO:0005355] RTQVPLLAGIP;TRDLQEMKEESRQMMREKK;VLQMFCTMPPTLG 3 7.7 1.0022 -0.7632 0 0 11.4576 8.70553 9.54504 0 0 0 0 0 0 0 0 0 0 A0A8C0QMS2 A0A8C0QMS2_CANLF Receptor expression-enhancing protein 5 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] IAYRTERFRECRSSSE;PSLPPPAPPLRPRPLPERLAFA 2 8.5 0.92551 0.095932 0 8.34283 0 0 0 0 0 0 10.5273 0 0 0 0 0 0 A0A8C0QMS6 A0A8C0QMS6_CANLF Mitochondrial brown fat uncoupling protein 1 (UCP 1) UCP1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive thermogenesis [GO:1990845]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; mitochondrial transmembrane transport [GO:1990542]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667] mitochondrial inner membrane [GO:0005743] cardiolipin binding [GO:1901612]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077] AMTMLTKEGPLAFF;GKRGPPPA;VVKVRLQAQSHLHG 3 6 0.98337 -0.25619 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82629 0 A0A8C0QMT2 A0A8C0QMT2_CANLF "Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; regulation of signaling [GO:0023051] plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DGDLQLWG;DPRGPGAAAPGSGP;EDQEDSGHDTMSYRDSYSECNS;EINTQSLEKVQQYY;GSANETIGQEDRGLSF;LLSTITEPTSGGSCDPP;LPSRLEGGASL;NNIRTMFHYEFRN;QEDREIQGAYL;TSVRSNSSYLGSDEMGSE;VLEHFQAFRSHQEEALGLYQWV;WHPVPSQGSNLTD 12 11.2 0.97615 0.048313 0 0 0 0 0 0 0 0 8.9216 0 0 0 0 0 0 A0A8C0QMT3 A0A8C0QMT3_CANLF RRM domain-containing protein SYNCRIP Canis lupus familiaris (Dog) (Canis familiaris) CRD-mediated mRNA stabilization [GO:0070934] CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 5'-UTR binding [GO:0048027] DYYGYDYHNYRGGYEDPYYGYEDF;EDYYDYYGYDYHNYRGGYE;EDYYDYYGYDYHNYRGGYEDPYY;PSVGTEVKKLKTCTFCSKC;YGPPHMPPPTRGRGRGGRG 5 11.1 0.98511 -0.44768 0 0 0 0 0 5.75002 0 8.57365 0 0 0 8.37599 0 0 0 A0A8C0QMY5 A0A8C0QMY5_CANLF Follistatin like 4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] LGRIFIPSALSWKW;PSDLLRFDDYNND;VTDSVVGPNGDV 3 4.6 0.9376 0.060957 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.42334 A0A8C0QN06 A0A8C0QN06_CANLF MSP domain-containing protein VAPA Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; phagocytic vesicle membrane [GO:0030670] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EAVWKEAKPDEL;IVCRFVQDHFDHNI;QEKQKNDLEPSKTVP 3 9.5 0.99745 -0.10455 0 0 14.2228 0 0 0 0 0 8.57251 0 0 0 0 0 0 A0A8C0QN15 A0A8C0QN15_CANLF Cortactin-binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of synapse organization [GO:0050807] cell cortex [GO:0005938]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978] ARDQARDQAKDRRSPPPGA;ARPAETPGPNQP;GNGTSECYYFHENC;KKPVCTNPLSI;LFISSACLIPVK;LRDELERLRRALEQLRRPGL;PGAAGPGA;SDLPVQQHFRW;TASGWSPSLTPLLMSGG;TYGSDDFE;VLMLVKECK 11 8.6 1.0026 -1.3582 0 0 0 0 0 0 9.82291 0 9.34789 0 0 0 0 0 0 A0A8C0QN48 A0A8C0QN48_CANLF Peptidyl-cysteine S-nitrosylase GAPDH LOC481849 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" EDIVTINDSFIDLNY;FGIVEGLMTTAHAITATQ;TINDSFIDLNYMVY 3 11 0.98662 -0.3857 0 0 10.201 0 0 0 0 0 0 8.8622 3.30999 0 0 0 0 A0A8C0QN72 A0A8C0QN72_CANLF "SEC24 homolog A, COPII coat complex component" SEC24A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] ESLTDTQLVSFQ;KTLPQMFTKTL;NKNPTMSR;PFKDLVQLPV;RRIRVHTLCLPVVSTL;VNFLDQRRWKCN;VSDIEDVFIPMP 7 7.9 1.0027 -1.4893 0 5.98666 0 0 0 8.25531 8.52117 0 0 0 8.76248 0 0 0 6.08047 A0A8C0QNA1 A0A8C0QNA1_CANLF Polycystin family receptor for egg jelly Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] AKPGDKLCPPAKSF;EAQFWISGHI;EARVVCIPPSL;EIRIFQRKKRIKRRAFL;EPEERRYIRSMMI;GFLLFLTILKTLRYSR;GPAQGDAAALRT;IRIFQRKKRIKRRAFLFLSYILTH;LDEKTWAVLL;PARVHLQPCT;PEPATDGPRPYP;QNAKDNKNQNAQPVT;QVVMSIAKLT;VENVFSRQIWLFMC;VVNTSISVH 15 8 1.0021 -2.6167 0 0 8.82464 5.40463 9.49711 9.00644 10.1812 10.3952 0 0 5.49787 11.3189 0 9.39408 9.45775 A0A8C0QNA5 A0A8C0QNA5_CANLF Rhotekin RTKN Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] REPRALPRQAQ 1 1.8 0.98409 -0.24739 0 0 0 0 0 0 0 0 0 0 0 0 0 8.58913 0 A0A8C0QNB1 A0A8C0QNB1_CANLF Tetratricopeptide repeat protein 5 OB fold domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GALTHCKN;LVDSDGPCCAVM;PGWPEPRQREQQLLEF 3 8.5 1.0018 -1.3096 0 11.0826 0 0 5.47842 0 0 9.42666 0 0 4.20992 0 0 0 0 A0A8C0QNC7 A0A8C0QNC7_CANLF Amine oxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] ATKVALVCEELFWEQDGI 1 3.8 0.97315 0.048313 0 0 0 0 0 0 0 0 0 0 7.93121 0 0 0 0 A0A8C0QND2 A0A8C0QND2_CANLF TOG domain-containing protein PPP2R1B Canis lupus familiaris (Dog) (Canis familiaris) EEPSGPGADKNHF;FCINALSEACGQEI;VRAAAAHK 3 5.5 0.94531 0.05966 0 0 0 0 0 0 0 7.72431 0 0 0 0 0 0 0 A0A8C0QND4 A0A8C0QND4_CANLF Tubulin gamma chain TUBG1 LOC100856176 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020] centrosome [GO:0005813]; cytoplasm [GO:0005737]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874] GTP binding [GO:0005525] SLKVPASNMTSCGSG 1 2.8 0.98619 -0.23219 0 0 0 0 0 0 0 0 0 0 0 8.24455 0 0 0 A0A8C0QNF4 A0A8C0QNF4_CANLF IRS-type PTB domain-containing protein DOK1 Canis lupus familiaris (Dog) (Canis familiaris) QELLGSPPALYAEPL;TVQRTEAAERCGL 2 5.8 0.99236 -0.19319 0 0 0 0 0 8.42555 0 0 0 0 0 0 0 0 9.21072 A0A8C0QNF5 A0A8C0QNF5_CANLF Ectopic P-granules autophagy protein 5 homolog Canis lupus familiaris (Dog) (Canis familiaris) ALGELKKLFDAKSEHL;ALKKAQAQLKLPII;DILMPFNLFCKHW;DLWMEYLNMER;ESQQVALDSELLDTMP;GALRLHLMHY;IFEPGSWLE;KLPIIPSLQRLLIYRWAH;LEFWVQALISQHLWYREQPILFLMD;LFFTVVDYVSDETQRHPPTRQFF;LVNCLYPEV;QPNEVGPVAVLE;RLSTLDFKSFGL;SEQKPSTSGP;SHLLLFLHLDSG;TLRNEMKVLLLLS;TRQFFTSCIEILGQFD;TVSYQSVLSYFSSHYQP;VNCLYPEVHYLDNI;YEVSYVTLSTRE 20 10.4 0.99923 -3.1091 11.7963 13.2145 0 5.11241 0 9.41234 10.2216 7.50597 12.3628 9.73407 7.36545 0 12.0702 11.7064 0 A0A8C0QNF6 A0A8C0QNF6_CANLF "NAD kinase 2, mitochondrial (EC 2.7.1.23) (NAD kinase domain-containing protein 1, mitochondrial)" NADK2 Canis lupus familiaris (Dog) (Canis familiaris) NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] mitochondrion [GO:0005739] ATP binding [GO:0005524]; NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803] ELVEKVTNEYNESLLYSPEEPKILF;LASYYEISVD;LSGPGAGGPTARPRLCGD 3 12.2 0.98667 -0.23471 0 6.48922 0 0 0 0 0 0 0 0 0 0 8.93779 0 0 A0A8C0QNG9 A0A8C0QNG9_CANLF "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3)" ACSS3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] nucleotide binding [GO:0000166] EAFKHLYFEKFP;KTPPPGQA;VEQSRGPGPSGR 3 3.6 1.0021 -1.2969 0 0 0 11.5189 0 0 0 8.88114 0 0 8.75832 7.45853 6.99774 0 0 A0A8C0QNI9 A0A8C0QNI9_CANLF "ATP synthase subunit f, mitochondrial (ATP synthase membrane subunit f)" LOC102151856 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven mitochondrial ATP synthesis [GO:0042776] "mitochondrial proton-transporting ATP synthase complex [GO:0005753]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" FTPKGIAGAFQRGQ;GPKAGAKP 2 13.8 0.9432 0.086067 0 0 0 0 9.66333 0 0 0 0 0 0 0 0 0 0 A0A8C0QNJ4 A0A8C0QNJ4_CANLF Histone acetyltransferase (EC 2.3.1.48) Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634] histone H3K9 acetyltransferase activity [GO:0043992] AAVVPSTPIFSPTMGGGSNSSLSL;LSHIIKKQKEIIKKLIERK;VEGSLGSPP 3 6.2 1.0023 -0.7135 0 0 10.1778 0 0 11.0596 0 0 0 0 0 0 0 0 6.18442 A0A8C0QNL1 A0A8C0QNL1_CANLF Ribosome production factor 2 homolog RPF2 GTF3C6 Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] CSFLHENEDDDI;EDADEDEEEAEQL;EDEEEAEQLVLVELSG;GVDTERPILQVDNY 4 20.8 1.0045 -1.0517 6.97957 0 0 7.99645 0 0 0 0 8.33432 0 0 0 0 0 0 A0A8C0QNN0 A0A8C0QNN0_CANLF Serum response factor SRF Canis lupus familiaris (Dog) (Canis familiaris) associative learning [GO:0008306]; axon extension [GO:0048675]; bicellular tight junction assembly [GO:0070830]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus cartilage development [GO:0060532]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac myofibril assembly [GO:0055003]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-matrix adhesion [GO:0007160]; cellular senescence [GO:0090398]; dorsal aorta morphogenesis [GO:0035912]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; erythrocyte development [GO:0048821]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; face development [GO:0060324]; filopodium assembly [GO:0046847]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; hematopoietic stem cell differentiation [GO:0060218]; hippocampus development [GO:0021766]; long-term synaptic depression [GO:0060292]; lung morphogenesis [GO:0060425]; lung smooth muscle development [GO:0061145]; megakaryocyte development [GO:0035855]; mesoderm formation [GO:0001707]; morphogenesis of an epithelial sheet [GO:0002011]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of miRNA transcription [GO:1902894]; neuron migration [GO:0001764]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; positive regulation of axon extension [GO:0045773]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive thymic T cell selection [GO:0045059]; primitive streak formation [GO:0090009]; regulation of cell adhesion [GO:0030155]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; sarcomere organization [GO:0045214]; skin morphogenesis [GO:0043589]; stress fiber assembly [GO:0043149]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea cartilage development [GO:0060534]; transcription by RNA polymerase II [GO:0006366]; trophectodermal cell differentiation [GO:0001829] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; serum response element binding [GO:0010736]" GGGGGGGG;GSSSNLTELQVVNLDAAHS;LVGGPEAAAAATGGYG;PGGGGGGG;YELSTLTG 5 10.2 0.98571 -0.44214 0 0 0 0 0 0 10.9555 0 0 0 0 0 0 10.8548 0 A0A8C0QNP2 A0A8C0QNP2_CANLF protein-synthesizing GTPase (EC 3.6.5.3) EIF2S3 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] EAPAVAVSTT;GGVAGGSI;ILMATMLNGAAVMDA;QEIEVRPGIV 4 7.5 1.0025 -1.7718 0 4.20578 10.4626 0 0 9.24567 0 9.6312 10.5498 0 0 0 11.2711 8.96003 0 A0A8C0QNV8 A0A8C0QNV8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFFLSFFLSFFLSSF 1 3.9 0.9839 -0.24311 8.96651 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QNX0 A0A8C0QNX0_CANLF Peptidase A2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] aspartic-type endopeptidase activity [GO:0004190] GHGPGGGC;LRPFENVVKVA;PCALCTCTCTCP;PGGGCAGP 4 5.9 1.003 -2.4957 0 0 9.21181 0 0 0 8.83532 8.79357 0 0 9.76739 0 9.73137 0 0 A0A8C0QNX3 A0A8C0QNX3_CANLF Radical SAM core domain-containing protein LOC479708 Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] membrane [GO:0016020] "4 iron, 4 sulfur cluster binding [GO:0051539]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]" EEEEPSESTSEEESG;EPSESTSEEESGTEDHQ;IPDYEIACEHEHSNCL;LVTNAQFPLEIRNLKPVTQLYVSVD;SASSLTMANVPWH;TEWRWKMDQPEMILKEAIE;VTYCGESSA 7 23.1 0.99387 -0.19108 0 11.2847 0 9.79669 0 9.63804 0 11.2852 0 0 11.2691 6.57043 5.26547 0 0 A0A8C0QP73 A0A8C0QP73_CANLF Zinc finger and BTB domain containing 7A ZBTB7A Canis lupus familiaris (Dog) (Canis familiaris) AAAAFPWSAF;AAAGDSDE;GAGGGGGD;GGGGGDGG;LKKDGCNGVPSRRGRKP 5 7.7 1.0032 -2.3652 0 0 10.9374 11.6359 11.5634 11.7282 0 0 0 12.322 12.0996 10.4735 11.275 11.6832 11.292 A0A8C0QP82 A0A8C0QP82_CANLF Interleukin 11 IL11 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410] cytoplasm [GO:0005737] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] LDRLLRRLQLL 1 9.2 0.98391 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 8.20833 0 A0A8C0QP85 A0A8C0QP85_CANLF Rho-associated protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; mitotic cytokinesis [GO:0000281]; positive regulation of centrosome duplication [GO:0010825]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell junction assembly [GO:1901888]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267] DTPFYADSLVGTYSK;EKVAKELEEEIT;ESLPYLPISSEPNGTESRLEGWLS;GVEEIKQHPFFKNDQWN;IYESIEEAKSEAM;KELNEMQAQIAEESQIRIELQMTL;LKEECEEKTKLCKELQ;NFDDIEDDKG;QKWVSRLVKKI;SPEVLKSQGGDGYY;VKKIPKKPPA;WVSRLVKKIPKK 12 11.6 1.0025 -1.8547 0 8.22535 0 0 0 10.3808 10.2182 11.7224 6.65864 8.48957 0 0 10.8207 0 11.1875 A0A8C0QPA9 A0A8C0QPA9_CANLF VWFA domain-containing protein ITGA10 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] metal ion binding [GO:0046872] ENAYNTSLSLSFSR;PFNLDVHHPRLFPG;SPFNLDVHHPRLFP;VLWLEEGHHLFPP 4 3.8 1.0013 -0.9498 0 9.18646 0 0 10.271 15.7182 9.44097 0 16.2454 0 0 0 0 0 0 A0A8C0QPD0 A0A8C0QPD0_CANLF TBC1 domain family member 9 TBC1D9 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] GDGGGGGG;GGGGGGGA;GRCPPGPAAAAIQIPVRRELPA;LVYWTIACGGSR;NDVKEDDD;QYFFEDITPEC 6 5.6 0.99361 -0.13038 0 0 8.62706 0 0 0 0 0 0 0 8.96122 0 8.55789 0 10.0116 A0A8C0QPG7 A0A8C0QPG7_CANLF Family with sequence similarity 169 member A FAM169A Canis lupus familiaris (Dog) (Canis familiaris) GSSDNAAT;SQETSTALP;TVDSSSEE 3 4.3 1.0026 -2.1732 9.7601 9.83758 8.14047 9.09685 0 0 9.50704 0 0 0 0 0 0 0 0 A0A8C0QPH8 A0A8C0QPH8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NUAK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ENKDKIVIIMEYASKGEL;LESLLEPGAPPE;PKGILKKRSNSEH;SLNHPHIISIYEVF 4 8.6 0.98646 -0.42529 0 0 6.13613 0 9.33706 0 0 0 0 0 0 0 9.94241 0 0 A0A8C0QPI4 A0A8C0QPI4_CANLF Prolyl endopeptidase (EC 3.4.21.-) PREPL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] DEEADNDNYE;LADLEACIKTL;LEAPFLDVLNTMM;VIEDSHKKASSPV 4 5.9 0.94306 0.059885 0 0 0 0 0 0 8.6397 0 0 0 0 0 8.23936 0 0 A0A8C0QPK1 A0A8C0QPK1_CANLF Calx-beta domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell communication [GO:0007154] membrane [GO:0016020] APGRSPNRDWVPM;DSFSFTVT;DSSHTEFYVF;DTDDLMLTFLLEDPPL;ELTLSPDGS;EPKEPGQS;FIPIRRSGDVSQELMVICYT;GAENNRGTNI;GAPGIASRAATG;LLLLLPLL;LLLLLPLLLSPVSRARAQP;LNLEACLWEFVSYYDMSEL;LSYSDYISRPEDHTSVIRFDKDEH;QEKGHHVLSETELRVD;RPLTGPAGSGPQNLVISDED;SHINYVQSVHKGVEPVEDRFI;TNDEQPEIFMREFMVM;TVEDGGIG;TYNQPVQQWSF;VPRLPPPLLLLLPLLL;VTRNLPLV 21 8.8 0.98939 -0.26592 0 0 0 0 0 0 0 0 0 0 11.7155 0 0 0 0 A0A8C0QPK7 A0A8C0QPK7_CANLF Fibroblast growth factor (FGF) FGF4 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] APGRTGPASPPSEAP 1 3.9 0.99265 -0.17864 9.37947 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QPM4 A0A8C0QPM4_CANLF Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) MOCOS Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] lyase activity [GO:0016829]; Mo-molybdopterin cofactor sulfurase activity [GO:0008265]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] EWPRRAQAARIQ;FNVLDHSGN;KVMVLKAKG;VGSQLLFMQVRSGEWPRRAQ 4 4.7 1.0029 -1.3297 0 0 0 9.0702 0 0 0 6.53211 0 10.3235 0 0 0 0 0 A0A8C0QPM6 A0A8C0QPM6_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CSNK1E Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] PPARPKRTWL 1 2.2 0.98901 -0.26139 0 0 0 0 0 0 14.2527 0 0 0 0 0 0 0 0 A0A8C0QPR7 A0A8C0QPR7_CANLF MDM2 proto-onco MDM2 SLC35E3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726] nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EQETLVRPKPL;ETLVRPKPLLLKLLKSV;LVRPKPLLLKLLKSV;RPKPLLLKLLK;TDSFEEDPEISLADYWK;YWKCTSCNEMNPP 6 14.5 1.0011 -0.95113 8.92985 0 0 0 4.69521 5.82431 0 0 0 9.72547 0 0 0 9.25571 6.54097 A0A8C0QPV9 A0A8C0QPV9_CANLF SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) SGIP1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583] clathrin-coated pit [GO:0005905] PAALTFRVI;PSRPKLPPGK;TVVSSPGP 3 3.2 1.004 -1.9751 0 0 0 0 0 0 0 13.487 0 7.72724 13.1987 8.16325 9.2165 0 0 A0A8C0QPW2 A0A8C0QPW2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] P-body [GO:0000932]; RISC complex [GO:0016442] metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] FPASGGDA;GADVTHPPAG;HVLWDDNRFSSDE;SPSSSPSFPSSLP;VELEVTLPGEGKDR 5 5.9 0.99066 -0.51566 11.6099 0 0 0 0 10.7044 0 7.35694 0 11.6664 0 0 11.0814 0 0 A0A8C0QPX0 A0A8C0QPX0_CANLF Zinc finger protein 865 ZNF865 Canis lupus familiaris (Dog) (Canis familiaris) AAYLLKHQ;GTPGPLPAPSQTPPGPAAG;GVCAKRFAQ;HQRCHTEQRPYRCGVCGRGFL;IVDLSGHQHLFGNLKRGGP;LEFLNHQRFEPMELYGEHAKAVA;SCGEGFANT 7 10.2 1.0031 -1.5049 0 11.2091 0 0 0 0 0 10.2279 0 0 7.16802 0 0 0 0 A0A8C0QPY5 A0A8C0QPY5_CANLF Peptidoglycan-recognition protein PGLYRP1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; zinc ion binding [GO:0008270] EAPLNSCCP 1 4.7 0.99216 -0.27195 0 0 0 14.8544 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QQ13 A0A8C0QQ13_CANLF IQ motif containing N IQCN Canis lupus familiaris (Dog) (Canis familiaris) LVEKKVSMEEGDIP;PQPCPVPTVTIAKT;PQTYPAAAMTKTP;QTVAIRLPCPVSLDTKCHPCLL;SLKTQTQAHMEAEVLKA;TRASLTTDALLGPAAW 6 6.1 0.9824 -0.25039 0 0 0 0 0 0 0 0 0 0 0 0 9.14601 0 0 A0A8C0QQ15 A0A8C0QQ15_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FHPRECELSKQEG 1 3.2 0.98835 -0.26104 0 0 0 0 0 10.7893 0 0 0 0 0 0 0 0 0 A0A8C0QQ90 A0A8C0QQ90_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) BRAF Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] DLSKVRSN;SIAETALTSGSSPSA;VISTPNVGLKLMT 3 4.6 0.9899 0.025712 0 9.66947 0 0 0 10.9117 0 0 10.4881 0 0 7.73532 0 9.26693 0 A0A8C0QQA2 A0A8C0QQA2_CANLF Potassium channel subfamily K member Canis lupus familiaris (Dog) (Canis familiaris) stabilization of membrane potential [GO:0030322] membrane [GO:0016020] open rectifier potassium channel activity [GO:0005252]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] GAGGGGGG;GGGGGGGA;LSTFRGLMKR;LVMFQSLGERINTFVKY;RLELRQQELRARYNLSQ;VLIGFFSCISTLCIGAAAF;VLRFMTMNAEDEKRDAEHRALL;VLRFMTMNAEDEKRDAEHRALLTRN 8 25.7 1.0025 -1.187 11.107 0 10.2159 12.0761 0 0 0 14.8377 0 0 6.99186 0 0 13.3738 12.3427 A0A8C0QQC6 A0A8C0QQC6_CANLF CNH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AGPGGLGM;ALDDEFITVHSMLDQ;CQMCQNPFCE;DLYRVHILIDRI;GAAICFPY;TEVANGYKEDIDTAL;TRSHPPLHEYADL;VECCGKNLYVGTDCV 8 11.2 1.0031 -2.2925 0 0 9.77147 0 0 0 0 0 0 0 10.5384 10.6594 10.1508 6.73863 0 A0A8C0QQD0 A0A8C0QQD0_CANLF Ferrochelatase (EC 4.98.1.1) Canis lupus familiaris (Dog) (Canis familiaris) heme biosynthetic process [GO:0006783] mitochondrial inner membrane [GO:0005743] ferrochelatase activity [GO:0004325] AATRGPAAAAAGGGASSSRRW;CSKQLTLSCPLCVNPVCR;DELSPHTAPHKYYIGFRYVHPLT;NRGDPYPQEVGA;VGATVQRVMD 5 11.7 0.98718 -0.37961 0 0 6.90376 0 0 8.76232 0 0 0 0 0 0 8.30076 0 12.8938 A0A8C0QQD5 A0A8C0QQD5_CANLF [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B (EC 2.1.1.361) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; muscle organ development [GO:0007517] histone H4K20 methyltransferase activity [GO:0042799] DEDYEEDFEDD;EEDEDYEEDFEDDF;INNSRVPKKLKKPAKPLLSKIK;KKLKKPAKPLLSKIKL;MGNLVLKEPKVVLYKNLPIK;MVVNGRRSGGKLSND;NNGFNSGSGSSSTKLKIQ;PKKLKKPAKPLLSKIK;PLLSKIKLR;SEGDEEDEDYEEDFEDDFIP;SSSEGDEEDEDYEEDFEDDF;VGCIAELSEIEE;VPKKLKKPAKPLLSKIKL;YSQYEEESTDEPSSSEGDEEDEDY 14 13.9 0.9885 -0.34317 7.34935 5.61238 8.27356 10.1784 0 0 7.07189 8.45195 9.18651 0 0 0 10.3335 0 7.37556 A0A8C0QQI7 A0A8C0QQI7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] multimeric ribonuclease P complex [GO:0030681]; nucleolus [GO:0005730] ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204] TYERIVYRNPSEHHY 1 12.1 0.95154 0.053874 0 0 0 0 0 0 6.42496 0 0 0 0 0 0 0 0 A0A8C0QQL0 A0A8C0QQL0_CANLF Kazal-like domain-containing protein MARCOL Canis lupus familiaris (Dog) (Canis familiaris) NQQERPGVLNQPGSLQE 1 5.4 0.98654 0.046227 0 0 0 8.85166 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QQM1 A0A8C0QQM1_CANLF Solute carrier family 16 member 10 SLC16A10 Canis lupus familiaris (Dog) (Canis familiaris) thyroid hormone generation [GO:0006590]; thyroid-stimulating hormone secretion [GO:0070460] basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; intracellular membrane-bounded organelle [GO:0043231] L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; thyroid hormone transmembrane transporter activity [GO:0015349] AGSSIFTI;FGYFVPYVHLMKHVNER;LCLIPWIHGK 3 6.8 0.99577 -0.56523 0 0 0 0 0 0 8.07157 0 0 0 0 0 0 0 0 A0A8C0QQS2 A0A8C0QQS2_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ASPRSQSLSRKESSSPSHQ;EEEEEEEEEEEEEEEEEEAVA;EEEEEEEEEEEEEEEEEEEEEEEE;EPGPEKLVTVSPSR;IHSVGFLH;LGLEAPSD;PGAEPSTSGTTDEEPE;PHLAPHPGGPEAE;SAPPGDTP;TKPDYQLIMS;TRQTAAMFGVVNVTPV;VGFSHVLLTT 12 12.7 1.0031 -1.6257 5.51118 12.184 0 0 0 10.0077 0 10.7986 13.0965 8.1878 0 8.46062 0 0 8.80193 A0A8C0QQT1 A0A8C0QQT1_CANLF ABC transporter domain-containing protein ABCA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDEDVKRERQR;FWEQRLDGLDWT;GMWEELSPKIWTFM;ITSFLGHNGAGKTT;LLVVILKLG;LVSAGLLVVILKL;PLSRIIWKALKPLLVG;QELFSMNSWSD 8 4.2 1.0035 -0.83647 8.70536 12.2428 9.43465 11.2539 5.76551 0 5.60703 11.8762 12.3503 0 0 0 12.2408 0 5.7433 A0A8C0QQU0 A0A8C0QQU0_CANLF Protein C receptor PROCR Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of coagulation [GO:0050819] extracellular space [GO:0005615]; membrane [GO:0016020] signaling receptor activity [GO:0038023] SDGPRNLHM 1 3.8 1.0044 -0.80421 0 0 0 0 0 0 0 6.62001 0 0 0 0 0 0 0 A0A8C0QQX1 A0A8C0QQX1_CANLF Formin homology 2 domain containing 3 MOCOS Canis lupus familiaris (Dog) (Canis familiaris) AERIIILKIVHRRI;ALCQGKDSREAGPASEQSPAGE;APESSTLS;PAAPASPTPLH;RPFEWPCKNNRRCREFL;SGGSSSAA;SKFRLVVKTALKLLLV;VEQLNIYEVALRH 8 6.7 1.0023 -1.2456 0 0 12.1572 9.40493 6.97304 3.59705 9.22877 0 3.15721 11.9027 11.8884 12.0062 12.6247 12.7857 12.9959 A0A8C0QR25 A0A8C0QR25_CANLF Gasdermin E Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] membrane [GO:0016020] AIPGELKPP;CGCGCGCGCGC;CGCGCGCGCGCGC;CGCGCGCGCGCGCGR;CGCGCGCGCGCGCGRP;CGCGCGCGCGCGR;GCGCGCGCGC;GCGCGCGCGCGCGCGR;GCGCGCGCGCGCGCGRP;GCGCGCGCGCGCGR;KYQFLSVTLGDVL;PSRGCGCGCGCGCGC;PSRGCGCGCGCGCGCG;PSRGCGCGCGCGCGCGCG;SRGCGCGCGCGCGCGCGRP;TTQQCVISEHVQI 16 8.9 1.0036 -1.0553 5.53148 0 0 5.1604 0 0 7.16892 0 0 7.97871 8.29457 0 4.96629 10.4006 0 A0A8C0QR66 A0A8C0QR66_CANLF Arachidonate lipoxygenase 3 ALOXE3 Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" APGSVQKYKVCCSTELGE;GPGKGGPG;LVGTCGQSPKQLLD;PSKLPVTNDMVAPL;YVTEHWCEDSFFGYQ 5 9.9 1.0029 -0.7381 0 8.29237 0 0 0 10.0593 0 0 0 0 0 10.425 0 8.10402 9.92318 A0A8C0QRH1 A0A8C0QRH1_CANLF 60S ribosomal protein L32-like LOC483242 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ALRPLVKPKIIKKRTK;ALRPLVKPKIIKKRTKK;IIKKRTKKFI;KPKIIKKRTKKFIWHQL 4 17.2 0.98363 0.046227 0 0 0 0 0 6.7137 0 0 0 0 0 0 0 0 0 A0A8C0QRJ5 A0A8C0QRJ5_CANLF Voltage-dependent N-type calcium channel subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268] neuronal cell body [GO:0043025]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891] calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331] AALMIFDF;DFAISAKPLTRYMPQ;EGGAAGAKG;ESKGLERDCRGQYLDYE;FSPGRLSRGL;GPGPPLGEGPAGCRRERRQE;GQYLDYEKEEVEAQPRQWKKYDF;HYDNVLWALLTLFTVSTGEG;IKSLRVLRVLRPLKTIKRLPKL;ISTIKSLRVLRVLRPLKTIK;ISVLRALRLLRI;ISVLRALRLLRIF;LRVLRVLRPLKTIKRLP;RPLKTIKRLPKLKA;RVLRVLRPLKTIKRLPKL;SSASLSNG;SYLRNGWNVM;TFEMVIKMIDL;TIKSLRVLRVLRPLKTIK;TLTFEEAVATNSGRSSRT;VLKHSVDATYEE;VLMMKFYDA;VLRPLKTIKRLPKLK;VLRVLRPLKTIKRLP;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKA;VLRVLRPLKTIKRLPKLKAVF;WTDILYNTNDAAGNTW;YFEMVILVVIALSSIALAAE 29 11.2 0.99976 -2.848 9.07847 12.2233 9.19227 0 0 0 8.10345 5.63677 9.49149 6.46158 0 9.62337 0 10.2627 8.96486 A0A8C0QRK2 A0A8C0QRK2_CANLF 2-oxoisovalerate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) TMEM91 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [GO:0016624]" EDASSSDSD;LFMAQCYGN;SEDPHLPQEK 3 5.3 1.0023 -0.97068 0 0 0 0 0 0 8.56159 0 0 0 11.2223 0 0 0 0 A0A8C0QRL1 A0A8C0QRL1_CANLF C2H2-type domain-containing protein ZFP62 Canis lupus familiaris (Dog) (Canis familiaris) EQRPGKLEASSAP;SENLSASLSECPLLP 2 2.6 0.98933 -0.26406 0 0 0 0 0 0 0 0 0 5.15364 0 0 0 0 0 A0A8C0QRP8 A0A8C0QRP8_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAHHGAGA;HGAGAFFRYMRQPIKQELICKWIEP;THPSSLRKHMK 3 8.7 1.0039 -1.0689 0 6.59646 0 0 0 0 9.80557 0 0 0 0 0 0 0 0 A0A8C0QRR4 A0A8C0QRR4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DMLGVGTWEAMPVNFPFSSGMTL;PWLSHHSFLEE 2 20.9 0.98343 -0.25544 0 0 0 5.0471 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QRS0 A0A8C0QRS0_CANLF KLF transcription factor 4 KLF4 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] GGGGGGGG;LMPPGSCMPEEP;PGGGGGGG 3 5.1 0.98982 -0.26373 0 0 0 0 0 0 0 8.12164 0 0 0 0 0 0 0 A0A8C0QRT2 A0A8C0QRT2_CANLF Peroxisome proliferator-activated receptor alpha (Nuclear receptor subfamily 1 group C member 1) PPARA Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of inflammatory response [GO:0050728]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" GGGAAPGG;HVLKLHLQTNHP;PDNIFLFPKLLQKMA;PGTSATCPRVLS;PRVPPLAPP 5 6.3 0.98779 -0.36763 8.31913 0 10.7755 0 11.4927 0 13.8179 13.8734 13.7648 0 0 0 0 0 13.9785 A0A8C0QRU8 A0A8C0QRU8_CANLF APC regulator of WNT signaling pathway APC Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; DNA damage response [GO:0006974]; insulin receptor signaling pathway [GO:0008286]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of pseudopodium assembly [GO:0031274]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of microtubule-based movement [GO:0060632]; Wnt signaling pathway [GO:0016055] adherens junction [GO:0005912]; beta-catenin destruction complex [GO:0030877]; bicellular tight junction [GO:0005923]; catenin complex [GO:0016342]; centrosome [GO:0005813]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587] beta-catenin binding [GO:0008013]; dynein complex binding [GO:0070840]; gamma-catenin binding [GO:0045295]; microtubule plus-end binding [GO:0051010]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin protein ligase binding [GO:0031625] ADVNSKKTL;AYCETCWEWQEAHEQGMDQD;DTPVCFSRNSSLSSLSI;EAESANTLQRAEIKENSG;EAHEQGMDQDKN;GSHEAERQNEGQGV;LEQIRAYCETCWE;NRSGTWKREHSKHSS;QIRAYCETCWEWQ;QLQGSIEDEAMASSGQIDLLE;SGSAQGST;TTSSGAAN;VMEEVSAIHTSQED 13 5.3 0.9976 -3.3945 8.7129 7.37112 9.38308 9.03213 8.25475 8.14832 0 0 8.35676 10.0901 0 8.20325 4.16664 0 10.8753 A0A8C0QRV0 A0A8C0QRV0_CANLF Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FSSLDGEA;TDKQRENY;TGHREGGGV 3 5.9 1.003 -1.9086 0 0 0 0 0 0 6.66959 0 0 0 0 0 0 6.21267 0 A0A8C0QRV6 A0A8C0QRV6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CGKVYRSQSEL;DAYYAVEMLYNQPDQ;DLQISEDNVI;EFLGHRIV;ICKTISCLLPDDLEV;KPLRRLGRPPKI;PNSSGPSQTF;QEPLDKDKVNEF;SECTSRFVTQYPC;TNSSFLKGGNGENAV;VLHKEDQIQEI;VLPSENNIE;VYHIFFLI 13 5.5 1.0032 -2.4559 0 8.2811 0 0 0 11.4238 0 11.2717 9.19849 0 9.01058 0 0 6.09189 0 A0A8C0QRX9 A0A8C0QRX9_CANLF Protein Abitram (Actin-binding transcription modulator) (Protein Simiate) ABITRAM Canis lupus familiaris (Dog) (Canis familiaris) dendrite morphogenesis [GO:0048813]; regulation of actin filament polymerization [GO:0030833]; regulation of filopodium assembly [GO:0051489] dendrite [GO:0030425]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785] TEPAAAEPAVPSLV;VNENILHKP 2 12.7 0.98791 -0.4807 0 0 0 12.6979 0 0 0 0 0 0 0 0 0 0 0 A0A8C0QRZ0 A0A8C0QRZ0_CANLF RNA-binding protein Luc7-like LUC7L2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA splice site recognition [GO:0006376] nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729] DQDLASRDRDR;SPRDRDRKDKK;VEQLGAEGNV;VLSGTAMDHLQSFIA 4 13.1 0.99361 -0.17398 0 0 0 0 0 0 0 0 0 0 13.4596 0 0 0 0 A0A8C0R975 A0A8C0R975_CANLF Ig-like domain-containing protein VSTM2B Canis lupus familiaris (Dog) (Canis familiaris) TVGATGAAGH 1 3.5 0.98793 -0.26491 0 11.7502 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0R995 A0A8C0R995_CANLF protein disulfide-isomerase (EC 5.3.4.1) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] AYNYRGPRTKDDIIE;DIWLVDFYAPWCGHCKKL;LKFRHFKGELTTFSMDQ;LPSQQMFEHVQKRHR;RLCSGASAALP 5 14.2 0.9875 -0.3378 0 0 0 0 9.88644 9.7339 0 6.77505 0 8.24831 0 0 0 0 10.6465 A0A8C0R9E2 A0A8C0R9E2_CANLF SCAN box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] EDDFTCRPE;FNNVRKCYV 2 8.4 1.0036 -0.80421 0 0 0 3.69633 0 0 0 0 9.05688 0 0 0 0 0 0 A0A8C0R9F2 A0A8C0R9F2_CANLF "Troponin T, cardiac muscle (Cardiac muscle troponin T)" LAD1 TNNT2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of muscle contraction [GO:0006937] troponin complex [GO:0005861] EQEEEEDWREHDD 1 4.5 0.95052 0.059561 0 0 6.30983 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0R9G2 A0A8C0R9G2_CANLF RNA polymerase II-associated factor 1 homolog Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] Cdc73/Paf1 complex [GO:0016593] chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993] AGEVSPLVFSQKGWAS;IPFDPKFITYPFDQNRFV;MMSQAMIRGMMD;NPKKKRKKRWRRKRKK;PKKKRKKRWRRKRKK;TNPKKKRKKRWRRKRKKLGA;VPWMRKTEYISTEF 7 14.1 0.85163 0.15131 9.28949 0 0 0 0 3.93763 0 0 0 0 0 0 0 6.12685 0 A0A8C0R9I6 A0A8C0R9I6_CANLF VASt domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; organelle membrane contact site [GO:0044232]; plasma membrane [GO:0005886] DVGHRIKH;ELGLTSDD;KEFLQLPSIEITPSS;SPSTPEQGVQRS;VILNMMLFYK;YVPPDDDFNTMGYC 6 7.4 1.0034 -2.2555 0 0 0 8.97459 8.22154 0 0 0 0 9.27968 9.61257 0 0 0 6.32117 A0A8C0R9J4 A0A8C0R9J4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) protein tetramerization [GO:0051262] membrane [GO:0016020] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] AEMSHVPQPQDFQ;AWDRMDIAKKHILIYGQHWKAG;DRPFTRSHSL;ESDQGQRQI;NNNNGDEIAPSNT;PLRSSNAADKISASLKSPPEPHH;PVVGLVVE;QNISDDLESTGF;SFLTPFLQAVYLF;SGEKKYQYYSMPP;VYMDMKSISNKLWKYNRY 11 7.8 1.0033 -1.6112 0 8.97857 13.5349 6.86728 10.1826 0 12.7758 0 0 0 0 0 10.7442 0 0 A0A8C0R9J6 A0A8C0R9J6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SYLWDHERIHT 1 2.2 0.98247 -0.24846 0 0 0 0 0 0 0 0 0 13.2673 0 0 0 0 0 A0A8C0R9K3 A0A8C0R9K3_CANLF Apoptosis-stimulating of p53 protein 2-like RA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cell cycle [GO:0045786]; regulation of apoptotic process [GO:0042981] nucleus [GO:0005634] p53 binding [GO:0002039] VEAIGFVRGYS 1 1 0.9856 0.035491 0 0 0 0 0 0 0 0 0 0 0 10.2853 0 0 0 A0A8C0R9K6 A0A8C0R9K6_CANLF RCAN family member 3 RCAN3 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676] CVCVCVCVCMC;EEEEEMVFGENEDDLEEMMD;GPGEKYELH;SDQEEEEEMVFGENEDDLE;TQTRRPEPPAAALKRRIA 5 18.4 0.93345 0.10722 0 0 0 12.6458 12.5836 0 0 0 9.21391 0 0 0 6.11162 0 2.93702 A0A8C0R9P2 A0A8C0R9P2_CANLF AP-3 complex subunit beta AP3B2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-3 adaptor complex [GO:0030123]; clathrin-coated vesicle membrane [GO:0030665] AEGQGEGSSSDEGSDSSS;EQQDLALLSISTFQ;VIGTMLVKDVVQA;VVIKKLLQ 4 4.7 0.98716 -0.50315 0 0 0 11.2182 0 0 0 0 0 0 0 11.9345 0 0 9.02159 A0A8C0R9V3 A0A8C0R9V3_CANLF Nonsense-mediated mRNA decay factor SMG5 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasm [GO:0005737]; nucleus [GO:0005634] DLLEGCELPDLPSSLL;DPLIGCKKPVSASGKEMDWAQ;PEAKVLHTKRLYRAVVE;QDLLEGCELPDLPS;SELTSLCQSVL;SRYQNELAGVDTELLAERFYYQ 6 9.1 0.98769 -0.33928 0 8.4822 0 0 8.74467 7.40574 0 0 0 0 0 0 8.6865 0 0 A0A8C0R9V7 A0A8C0R9V7_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DSCPEEEEEEEEEE;RAKMPLALDFTGYRHPVATFQ 2 7 0.92467 0.10857 0 0 0 0 0 5.88506 0 0 6.9191 0 0 0 0 0 0 A0A8C0R9X1 A0A8C0R9X1_CANLF Olfactory receptor OR6X1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FIVIFFIYILTL;LTVVSLLYGA;LTVVSLLYGAVLF 3 8 0.98812 -0.47682 0 0 0 0 0 0 0 0 9.53064 0 10.1059 3.62947 0 0 0 A0A8C0R9Y1 A0A8C0R9Y1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] ETYGPFQIRIQ;KDSVGQAQLSQEGP;STGPIVVHCRYAAPV;VGWGGQGSWPLLLRR 4 21.5 0.9391 0.06073 0 9.69897 0 0 0 10.6747 0 9.74147 0 11.2409 0 10.8909 0 0 11.5282 A0A8C0R9Y9 A0A8C0R9Y9_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) LOC119871403 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] IEMILTEKEQIVPKPEEEVAQK;VGRCAQNFF 2 16.5 0.98508 -0.25927 0 0 0 0 0 0 0 0 0 0 0 10.8039 0 0 0 A0A8C0R9Z8 A0A8C0R9Z8_CANLF Fructose-bisphosphate aldolase (EC 4.1.2.13) ALDOA Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] I band [GO:0031674]; M band [GO:0031430] fructose-bisphosphate aldolase activity [GO:0004332] AGAAASES;GLDGLSERCAQ;KVDKGVVPLAGTNGETT 3 8.7 1.0025 -1.0215 10.076 0 0 0 0 0 0 0 0 0 0 0 7.86431 12.2731 0 A0A8C0RA03 A0A8C0RA03_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AGFEPVPECSDGAIHSWAVEG;GPAFHPNSMIFSIREGIRGNS;IEVPDVNDYCP;LEACDCDNDHICL;PTGIGMMALGLLLLLLSPLLL;VLDVNDNFPTLE;YGGREMQDLG 7 5.7 1.0033 -0.97524 7.95907 0 10.0364 0 0 0 11.6182 8.88493 0 0 0 0 0 0 0 A0A8C0RA10 A0A8C0RA10_CANLF Cms1 ribosomal small subunit homolog Canis lupus familiaris (Dog) (Canis familiaris) ESLEIFGGDSL;NLPDSCFLKANDLTHSL;PSKINVCC;TKIKLSFANFSV;VTKTRRRRKKKITDVLA 5 20.3 0.98362 0.046227 6.98755 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RA31 A0A8C0RA31_CANLF Protein-tyrosine-phosphatase Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AKESLTSKMLEA;CAVAGPWRAVGPH;LVSLCPPDTWEQQSWPTETQPI;PSDLAIGWAPAPGPRE;PYDHSQVR;VPLPAAVG 6 4.9 0.97401 0.046925 0 0 0 0 0 0 0 0 0 0 6.97808 0 0 0 0 A0A8C0RA37 A0A8C0RA37_CANLF Transthyretin TTR Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179]; thyroid hormone binding [GO:0070324] ALLSPYSYSTTA;ALLSPYSYSTTAL;ALLSPYSYSTTALVSNPKE;EPFASGKTSEF;GPAGTSGPKCPLM;LLSPYSYSTTALVSNPKE;LSPYSYSTTALVSNPKE;PYSYSTTALVSNPKE;RHYTIAALLSPYSYSTTALVSNPKE;SPYSYSTTALVSNPKE;STTALVSNPKE;SYSTTALVSNPKE;TALVSNPKE;TIAALLSPYSYSTTALVSNPKE;TTALVSNPKE;VAVKVFKKTADET;VKVLDAVRGSPAVN;YSTTALVSNPKE;YSYSTTALVSNPKE 19 51.7 0 124.04 14.9904 14.9688 14.9907 14.2042 14.556 14.4688 15.4194 15.6398 15.6413 14.5893 14.7429 14.6129 14.6163 15.3391 14.7469 A0A8C0RA49 A0A8C0RA49_CANLF Hemicentin 1 HMCN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DICQHECKNTFGSYHCIC;DPIVMGQKH;FCADEDECAAGS;PNYQRDPVSGF 4 5.6 1.0035 -0.80421 0 0 0 0 9.195 0 0 0 0 0 0 0 0 0 0 A0A8C0RA54 A0A8C0RA54_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DSRLLNKVDA;LEVMLEDNVCLPS;STKNHQESSP;VGGSNGHSDDLSCGEMYDPSIDDW 4 8.3 1.0016 -0.70011 10.4635 0 0 0 0 4.617 10.9359 7.88429 0 0 0 0 0 0 0 A0A8C0RA59 A0A8C0RA59_CANLF Spectrin beta chain SPTBN4 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; central nervous system projection neuron axonogenesis [GO:0021952] cell junction [GO:0030054]; cell projection [GO:0042995]; plasma membrane [GO:0005886]; spectrin [GO:0008091] actin filament binding [GO:0051015]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200] AAGGGGGG;ADEREAVQK;DIVEQLQEKEAGPG;EDARLHVSSTA;EQEVLQGWKELLAACE;GALAAVAA;GGGGGGGA;LEQQYWLYQLSRQ;PSSDEVRSCQDH;QVRPRPERQESAD;SNQKFANSLSGVQQQLQ;TVQELVEGGHPSS;VGARRTRLEQNLALQK;VQELVEGGHPSSDEVRSCQDH 14 5.8 1.002 -1.8256 0 10.0867 0 0 12.3043 0 0 8.25479 11.4266 9.4745 0 8.11181 9.55518 10.0371 0 A0A8C0RA84 A0A8C0RA84_CANLF Tryptophan synthase beta chain-like PALP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) D-serine biosynthetic process [GO:0070179] cytoplasm [GO:0005737] ATP binding [GO:0005524]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114] VLSGGNVDLASLTWVKQAE;VLSQHFQTVSSE 2 27.9 0.98436 -0.25737 0 0 0 0 9.83826 0 0 0 0 0 0 0 0 0 0 A0A8C0RA86 A0A8C0RA86_CANLF Pre-rRNA-processing protein TSR1 homolog Canis lupus familiaris (Dog) (Canis familiaris) "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" "preribosome, small subunit precursor [GO:0030688]" GTP binding [GO:0005525]; GTPase activity [GO:0003924]; U3 snoRNA binding [GO:0034511] VLHYMFFS 1 4.8 0.98932 -0.21651 0 0 0 0 10.0414 0 0 0 0 0 0 0 0 0 0 A0A8C0RA87 A0A8C0RA87_CANLF Ceramide synthase 3 CERS3 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; cornification [GO:0070268] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] VIGGGWPVGQASAQSRSWP;VLHLYWCYFILKMLRRCIFMKK;YCTLILPLHYLEP 3 12.1 0.8612 0.16048 0 0 0 0 0 0 6.37412 0 8.68762 0 0 0 0 0 0 A0A8C0RAE6 A0A8C0RAE6_CANLF Meprin A subunit (EC 3.4.24.-) (Endopeptidase-2) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EDWWYMGERCER;RDDYVRIMWDRIQSGRE 2 4.1 0.94685 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 7.43555 0 0 A0A8C0RAH8 A0A8C0RAH8_CANLF NLR family pyrin domain containing 5 Canis lupus familiaris (Dog) (Canis familiaris) DDWYSFDED;EVQLVKPQI;KLSHVIVRNKHLKSLDLAV;KRIQLLCQHTK;PNMKEGPGQCECD 5 5.6 1.0031 -2.1446 0 0 6.38607 7.91743 0 0 0 0 8.84147 9.40401 0 0 0 0 10.2944 A0A8C0RAI0 A0A8C0RAI0_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCH2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] GAMQREMNALFVQKL;GAPWQGPG;GFSKRKKKSSK;GLRRGQLPSPG;GVLGIDGF;LRLRPLVPRLPWGHLP;SQVVRRAESEGQVP;SVAGDGVPGPP;TDLQRFLEVEQ 9 6.8 1.0034 -1.6986 0 0 0 0 8.09318 0 6.70543 5.25776 0 6.48795 0 9.11533 8.53524 7.21023 0 A0A8C0RAI3 A0A8C0RAI3_CANLF WD repeat domain 1 Canis lupus familiaris (Dog) (Canis familiaris) AATPGPGA 1 1 1.0039 -1.1044 8.85842 0 0 0 0 0 0 0 0 0 0 9.51078 0 0 0 A0A8C0RAJ2 A0A8C0RAJ2_CANLF Lysophospholipid acyltransferase 7 (Leukocyte receptor cluster member 4) (Membrane-bound O-acyltransferase domain-containing protein 7) MBOAT7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] FRYRTYLDWLEQPF;NAVQLLLTLKL;NWGRGGEPGRSSLEG;SYVLRSAWTMLL 4 10.3 0.98634 -0.45462 0 0 0 8.88676 8.44576 0 0 0 0 0 8.79455 8.99633 9.40591 0 0 A0A8C0RAK2 A0A8C0RAK2_CANLF Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase (EC 2.4.1.135) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; protein glycosylation [GO:0006486] extracellular region [GO:0005576]; Golgi membrane [GO:0000139] galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872] LILQRSQAYFKL;SWGVHFAGLLSAPWHSHP;WHSHPFPLSGLARPCK 3 9.7 0.53889 0.44087 0 0 8.28378 0 0 0 11.5273 11.496 0 0 0 0 0 0 10.8757 A0A8C0RAM9 A0A8C0RAM9_CANLF Annexin Canis lupus familiaris (Dog) (Canis familiaris) cytokinetic process [GO:0032506]; phagocytosis [GO:0006909] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] PLWSEATVD;RSSWQRLSMFSSSL 2 4.3 1.0025 -0.74001 0 0 8.88496 0 0 0 0 0 0 0 0 0 0 11.2152 0 A0A8C0RAP4 A0A8C0RAP4_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; regulation of neurogenesis [GO:0050767] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VEKMRRDRINSSIEQL 1 14.2 0.96293 0.049233 0 0 0 0 0 0 0 7.78542 0 0 0 0 0 0 0 A0A8C0RAQ0 A0A8C0RAQ0_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EARHWGHR;GAALAACGA;IVSWGYDCGLPKRP;PARLLVLIPL;QTCDAYYQENSNNPSQEPIIFEDM;TSDPTTWD;TSQIQSSAQ 7 23.3 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.76315 A0A8C0RAQ6 A0A8C0RAQ6_CANLF Small integral membrane protein 17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RGLLEPERTKMLLP;VAVEVEAASCDSDEKG;VEGDEESEDS;VLTGMPMMFHI;VSETLRPWKM 5 41.2 0.99563 -0.56725 0 0 0 0 0 0 0 0 0 0 0 7.71802 0 0 9.99718 A0A8C0RAR1 A0A8C0RAR1_CANLF DNA polymerase (EC 2.7.7.7) POLD1 Canis lupus familiaris (Dog) (Canis familiaris) "base-excision repair, gap-filling [GO:0006287]; DNA replication proofreading [GO:0045004]; nucleotide-excision repair, DNA gap filling [GO:0006297]" delta DNA polymerase complex [GO:0043625] "3'-5'-DNA exonuclease activity [GO:0008296]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" ELCSRESECC 1 0.9 0.99899 -0.61146 4.3256 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RAR6 A0A8C0RAR6_CANLF RING-type domain-containing protein RNF180 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EALPEWINCL;ITRNHNQEDLS;IYIYSVNWVIGFIVFCFLCYF;LEDQIFTDRHH;RRHERWLQKQTLNNEMSTDDDNE;SNNLTFLMDLPSAGR;TACPRLKETQP;TLNNEMSTDDDNEYAEE;YIYSVNWVI 9 18.3 1.0021 -0.99468 0 7.64796 0 10.1197 8.59111 10.3588 0 0 0 0 8.31293 0 11.5867 0 0 A0A8C0RAR8 A0A8C0RAR8_CANLF Docking protein 7 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase binding [GO:0019901] EPSLCACPPG;ESGPATLHLCNDVLVVARD;HRGSPQGGGP;KGAAASPPGLL 4 6.1 0.99986 -0.61146 0 10.547 0 0 0 0 9.87346 9.86378 0 0 0 0 2.94158 0 0 A0A8C0RAS3 A0A8C0RAS3_CANLF RAB GTPase activating protein 1 like RABGAP1L Canis lupus familiaris (Dog) (Canis familiaris) LLGRWHSNLGA;LLLTKQRLVETEE;SSPRNEVE;YRAEENARRLMEQAC 4 4.6 0.98854 0.032489 0 0 0 0 0 0 0 0 6.77795 0 9.11842 0 8.78604 0 0 A0A8C0RAS6 A0A8C0RAS6_CANLF D(1A) dopamine receptor (Dopamine D1 receptor) Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; vasodilation [GO:0042311] ciliary membrane [GO:0060170]; dendritic spine [GO:0043197] "dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]" ETMDNCDSSLSRT 1 3 0.99075 -0.27503 0 0 0 0 0 0 0 0 0 0 0 0 11.0932 0 0 A0A8C0RAT5 A0A8C0RAT5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IHTPTHPP 1 2.1 1.0048 -1.1044 0 0 0 7.80986 0 7.76474 0 0 0 0 7.17193 0 0 0 0 A0A8C0RAW0 A0A8C0RAW0_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cytoplasmic translation [GO:2000766] cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202] "mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]" DQMCDECQ;GGGGFGGP;GGGGGGGA;GGGGGGGG;GGGGGGSG;IFVGGVPRPL;LPGGALGAGAFSSLQSPDLPH;NVTCLQYYCEFCW;PDSKPPPPPPPPLHCPG;PGGGGGGG;PLGCGGAG;PPGGGGGGG;SSSASSCCCC;VCYAGIDTDPELK;VGGVPRPLRAVELAMI;VLDDQMCDECQGARCG 16 16.2 0.99695 -4.1515 0 5.96906 9.73951 8.37286 8.87083 10.5655 0 0 0 0 8.10941 0 0 2.99143 9.09563 A0A8C0RB10 A0A8C0RB10_CANLF ETS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" SYSPSPGLSPFT;SYSPSPGLSPFTS 2 2.6 0.74221 0.24286 0 10.6517 0 0 0 0 0 0 12.0474 0 0 0 10.1288 0 0 A0A8C0RB11 A0A8C0RB11_CANLF Gem-associated protein 2 GEMIN2 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] SMN complex [GO:0032797]; spliceosomal complex [GO:0005681] ETLKRNSR 1 2.9 0.98922 -0.19957 0 0 0 0 0 0 8.77113 9.03672 0 0 0 0 0 8.08667 0 A0A8C0RB26 A0A8C0RB26_CANLF C2H2-type domain-containing protein ADNP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EEELIHHLLMHGLGCL;KTVGRHFRMFHAP;PKTEDSLSTEKMPPSDKY 3 4.3 0.85008 0.15717 0 5.68063 0 0 0 0 0 8.16556 0 0 0 0 0 0 9.88768 A0A8C0RB30 A0A8C0RB30_CANLF Zinc finger protein 785 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DCGRNFSYPSL;LSEEVSIEEWLPSSRPPGASH;MRETYETSGRTQ 3 16.9 0.99457 -0.12779 0 10.5618 8.18334 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RB31 A0A8C0RB31_CANLF C2H2-type domain-containing protein ZFP1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CGKTFAQKFELTTHQRIHTGERPYE;FKKSNLIIHQKIH;IHTGEKPYECNV 3 13.4 0.86069 0.14554 0 0 0 0 0 0 6.88142 0 0 0 0 0 8.90159 5.2572 0 A0A8C0RB60 A0A8C0RB60_CANLF THO complex 6 THOC6 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] THO complex [GO:0000347]; transcription export complex [GO:0000346] PGEALCLASATF 1 2.8 0.94477 0.05044 0 0 0 0 0 0 10.0046 0 0 0 0 0 0 0 0 A0A8C0RB69 A0A8C0RB69_CANLF MORN repeat-containing protein 5 MORN5 Canis lupus familiaris (Dog) (Canis familiaris) motile cilium [GO:0031514] GCYDCGDG;SPDGASLT 2 5.3 1.0022 -1.3703 0 5.74543 0 0 0 0 11.8507 0 11.8098 0 0 0 0 0 0 A0A8C0RBD5 A0A8C0RBD5_CANLF Suppressor of cytokine signaling 7 SOCS7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567] AASLTDMGGS;AGPSRKGSLK;CCPCPCPCPPQ;IAPIRAAESLH;LETNSCSEEE;LKIRLSRLFR;QPPGPELPPVPFPMQ;VGAGCCPCPCPCPPQ;YIRKFYYYDPQEEVYLSL;YWGPMNWEDAE 10 18.8 1.0031 -2.3006 0 0 0 0 0 8.39618 0 0 0 8.8021 5.52162 0 0 10.6634 9.22282 A0A8C0RBD6 A0A8C0RBD6_CANLF Treacle ribosome biosis factor 1 TCOF1 Canis lupus familiaris (Dog) (Canis familiaris) AGPSAAQAKTEKPKE;EDSDSSEEDSDSEEE;EDVIPATQCSVPAGRTNVTPLT;KKKKKKKK;KPEEDSESSEEESESEDGAPAEP;PAGRTNVTPLTAH;QEEDSESSSEEESDSEGA;QKKKKKKK;SEEDSDSEEEPPAAKTPL;SEEEAPTAVPPTRSPA;SETSNDSEDSSGSSSGSEE;SSSSEESESEEETAPAPAAGQV;TPRPDLNPSA 13 12.5 1.0027 -1.4913 10.0642 0 10.7332 0 11.6455 0 6.81506 0 13.5663 0 0 0 6.81762 0 10.1528 A0A8C0RBE1 A0A8C0RBE1_CANLF P53 apoptosis effector related to PMP22 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGGSCPCCC;GGSCPCCC;GGSCPCCCS;PCCCSAPSPS;SLVIYPVKYTQTFN 5 8.2 0.99884 -2.9714 0 7.06985 0 0 0 0 6.86071 7.45096 0 8.85929 0 0 0 6.72683 6.63852 A0A8C0RBE4 A0A8C0RBE4_CANLF Ubiquinone biosynthesis protein Canis lupus familiaris (Dog) (Canis familiaris) ubiquinone biosynthetic process [GO:0006744] mitochondrion [GO:0005739] lipid binding [GO:0008289] EEEDHESEEQLQHR 1 6.8 0.93759 0.060892 0 0 0 0 0 0 0 8.4022 0 0 0 0 0 0 0 A0A8C0RBE7 A0A8C0RBE7_CANLF Centrosomal protein 192 SEH1L Canis lupus familiaris (Dog) (Canis familiaris) centrosome duplication [GO:0051298]; centrosome-templated microtubule nucleation [GO:0090222]; protein localization to centrosome [GO:0071539] DIHTVDLGAT;DIHTVDLGATNKNIREPEENTV;DIWDLSLPKEQTTQDIHTV;IHDVSFDFHGRRMAT;LARVDIEVDSPNP;LENHGNAEVKWHL;PVVSAMPHLPV;SETTHKESEVGHVVCLPG;SLEDSSDDDIDDEE;VSETALIPSRQPDLTHRGVYAS;WHLSSLAP 11 5 1.0024 -1.7917 10.2504 8.95826 11.2937 0 0 9.20572 7.21791 9.41238 10.4773 0 0 0 11.6625 8.12969 10.9769 A0A8C0RBF7 A0A8C0RBF7_CANLF Fibroblast growth factor receptor (EC 2.7.10.1) FGFR4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284] endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; fibroblast growth factor receptor activity [GO:0005007] LSLEASEEIELEP;MLKDNASDKDLAD;REAGQGWQ 3 4.5 0.99366 -0.11907 10.1856 0 0 9.1264 0 0 0 10.39 9.29073 0 10.6592 9.51177 0 0 0 A0A8C0RBG2 A0A8C0RBG2_CANLF Tripartite motif containing 80 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ACGHNFCMTCLQ;HQLLEPVWDLKSRLC 2 4.7 0.91212 0.11112 0 0 0 0 0 0 6.73132 0 0 0 7.92653 0 0 0 0 A0A8C0RBG4 A0A8C0RBG4_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DHMVGAPRCPDGGVLRPPPATPVS 1 5.3 0.97348 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.46499 A0A8C0RBG7 A0A8C0RBG7_CANLF Carbohydrate-binding/sugar hydrolysis domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; spindle [GO:0005819] AEAVECWKKYYEI;GTGVCVLT;QLPPASQAEGRA 3 5 0.98733 -0.47893 0 0 0 0 8.3077 0 0 0 0 4.70194 10.1891 0 10.4558 0 9.231 A0A8C0RBH8 A0A8C0RBH8_CANLF DMRT like family C2 DMRTC2 Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin organization [GO:0070828]; male meiosis I [GO:0007141]; regulation of DNA-templated transcription [GO:0006355]; spermatid nucleus elongation [GO:0007290] nucleus [GO:0005634]; XY body [GO:0001741] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] EAAEALVGLKDSSQ;STPDPLLLQPQAPGAS 2 8.1 0.99445 -0.15922 0 0 0 0 0 9.46732 0 14.1372 0 0 0 0 0 0 0 A0A8C0RBJ7 A0A8C0RBJ7_CANLF Small ribosomal subunit protein eS19 (40S ribosomal protein S19) RPS19 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GEAAFALREAER 1 3.2 0.98377 -0.24297 0 0 0 0 0 0 0 10.4241 0 0 0 0 0 0 0 A0A8C0RBK2 A0A8C0RBK2_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] ENRSEGPCCFYS 1 12.9 0.94437 0.05044 0 0 0 0 0 5.40194 0 0 0 0 0 0 0 0 0 A0A8C0RBK7 A0A8C0RBK7_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LAPLMTCPPLCL 1 4.9 0.94525 0.05044 0 0 0 0 0 0 0 9.57879 0 0 0 0 0 0 0 A0A8C0RBL5 A0A8C0RBL5_CANLF Hyaluronan and proteoglycan link protein 3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540] LVFPFTAPPA;LVFPFTAPPASLRFG 2 2.9 0.98249 -0.25133 0 4.01257 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RBN1 A0A8C0RBN1_CANLF RAS protein activator like 2 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] ISNPDTISNTPGFD;MLDRILLESVCQQQSWVRVYDVKGP;NSMDTVNTSPFKVPG;RYSMQILPQVS 4 4.7 0.8535 0.19231 0 9.34751 0 0 9.67992 0 0 0 0 4.50443 0 0 8.08151 10.5661 0 A0A8C0RBN3 A0A8C0RBN3_CANLF B-cell receptor CD22 (Sialic acid-binding Ig-like lectin 2) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AERVLSEDT;VISSNPEYRRITWLKDG 2 3.5 0.99031 -0.21543 0 0 0 0 0 0 0 11.4719 0 0 0 0 0 0 0 A0A8C0RBQ1 A0A8C0RBQ1_CANLF Glutathione peroxidase GPX3 Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] extracellular space [GO:0005615] glutathione peroxidase activity [GO:0004602]; selenium binding [GO:0008430] VILGFPCNQFGKQEPGEN 1 8 0.97779 0.048313 0 0 0 0 0 0 0 8.40237 0 0 0 0 0 0 0 A0A8C0RBQ5 A0A8C0RBQ5_CANLF Phosphatidylinositol 3-kinase regulatory subunit alpha (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) PIK3R1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AFNETIKIFEEQCQSQ;EDNIEAVGKKLHEYNTQFQEKSR;FAPPDIAP;VEVHEFLYLRA;VVDGEVKHCVI 5 9.1 1.0017 -1.2539 0 6.9458 0 10.2295 0 0 0 7.07596 9.45415 0 0 0 0 0 0 A0A8C0RBR2 A0A8C0RBR2_CANLF Protein transport protein sec16 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; protein transport [GO:0015031] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] AEGGWPATEQDQ;EEGFGGKFANLVPSHFFSLTFFPQ;EQEELRSFPGPLGK;KKTTKLVLIGS;QVGALSPSPVSQVYRNHGV;VGALSPSP 6 10.3 1.0022 -1.0133 0 9.34753 6.89239 0 0 0 0 0 0 0 0 0 10.2292 0 0 A0A8C0RBT6 A0A8C0RBT6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TNAMKHRDTCTPMFLAAMA 4 4.2 0.98587 -0.25842 0 0 0 0 0 0 0 0 0 0 0 0 0 9.93388 0 A0A8C0RBU3 A0A8C0RBU3_CANLF Glycosyl hydrolase family 38 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] lysosome [GO:0005764] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246] AGHLVMWMDGWMDGWMDGWMMDGW;HLVMWMDGWMDGWM;MDGWMDGWMMDGWKN 3 5.9 0.84735 0.15596 0 0 0 0 0 2.28738 9.84281 0 0 0 0 0 0 8.52654 0 A0A8C0RBU7 A0A8C0RBU7_CANLF DUF4685 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FPDGTTQLQLQRSPEG;GVDHAEGA;GVPPERPAGDVDWDSG;HRHEEAKHLLQRARMKARTRPL;LLPQSEESVSP;LSEPGEPADTPL;NGHLPRPWSCSL;PESLETISASSL;QNGHTSDSSSGESSSGRWPR;RGPPRSEPDLGRYG;SSSSLASTLG;VTPGQPGGP;WNGRSPWPPEAV;WPGITPLLPQSE 14 16.1 0.98208 -0.24916 0 0 0 0 0 0 0 0 0 8.37069 0 0 0 0 0 A0A8C0RBU8 A0A8C0RBU8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;GEALGAFPLRSGTREGCP;GVLKKKTIS;HKLPKLEQEETE;MNEKGEITTNT 5 8.6 1.0018 -0.75147 0 0 0 0 0 9.38972 0 0 0 0 0 0 0 0 10.0347 A0A8C0RBZ6 A0A8C0RBZ6_CANLF Sarcalumenin SRL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525] EEAPMRDRSHIEKTLMLNEDKPVD;IVMAADSARS 2 7.2 0.99195 -0.13875 0 0 0 0 0 0 9.65322 0 0 0 0 12.1181 0 0 0 A0A8C0RC03 A0A8C0RC03_CANLF MARVEL domain containing 2 MARVELD2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] FSEYKELSAEVQ;GTLRTLGDSELAVSADPLPPPP;YPLFNTPMNAL 3 8.6 0.98634 -0.45525 0 0 0 0 0 0 11.0017 0 0 0 0 0 0 8.62018 0 A0A8C0RC07 A0A8C0RC07_CANLF tRNA splicing endonuclease subunit 54 TSEN54 Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] EQQAEAQRFREDVNSDPEVQC;PPPCNQNSRCPEEKPQE 2 7.2 0.98906 -0.52399 0 0 0 0 0 9.32928 0 0 0 0 0 0 0 0 0 A0A8C0RC09 A0A8C0RC09_CANLF POU domain protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGGGGGGA;GGGGGGGG;GGSGGPEAG;HHLQPPAQFLLPQAQQ;PAQFLLPQAQ;PGLSSSSSSSSSSSSTCSEAAAQ 6 10.3 1.0029 -1.5156 9.75779 0 0 0 0 0 0 0 0 10.1449 0 0 0 0 0 A0A8C0RC19 A0A8C0RC19_CANLF Low density lipoprotein receptor class A domain containing 4 LDLRAD4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901] R-SMAD binding [GO:0070412] RFQPTYPYVQ;SLSDGEEPPPYQ 2 8.3 0.99978 -0.61146 3.62504 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RC42 A0A8C0RC42_CANLF Fem-1 homolog C FEM1C Canis lupus familiaris (Dog) (Canis familiaris) MTPLLSASVTGHTNIVDFLT 1 3.6 0.98643 -0.23478 0 0 0 0 11.5402 0 0 0 0 0 6.66619 0 0 0 0 A0A8C0RC47 A0A8C0RC47_CANLF Thrombospondin-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] PGEKGEEGLQGIPG;PGLDGNPG;SIAQKGDTGP 3 2.9 0.99774 -0.088572 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.16594 A0A8C0RC63 A0A8C0RC63_CANLF Glycosyltransferase 2-like domain-containing protein GALNT18 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] Golgi apparatus [GO:0005794]; membrane [GO:0016020] polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] APDIVSKRGVIVVAVLLLFYLI;GAQDGVHQEDQNFGV;LSPEGRRMALK;PVDDPRHVL;TSSEREVNCP;VGILSPTVDDDDNR 6 11.4 1.0004 -0.61936 0 0 4.60774 5.57701 12.1605 10.8387 0 12.6132 11.4623 0 0 0 4.34234 0 0 A0A8C0RC64 A0A8C0RC64_CANLF Coiled-coil domain containing 112 CCDC112 Canis lupus familiaris (Dog) (Canis familiaris) DEVKAPETFIHLP;EKKQQKERRRQFKLKLLL;ISRDPSRLYR 3 7.8 0.99505 -0.15765 0 12.0481 0 0 7.70798 0 0 0 0 0 0 0 0 0 0 A0A8C0RC74 A0A8C0RC74_CANLF EFR3 homolog B Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659] plasma membrane [GO:0005886] LVDNIFPEDPED;QVVEKFQKAPFEEIAAHCG;RLVLAVQDVAQVN;SFVKFANIEE;SRFSEMCHSSHDDME;VGVCGCCGA;VKTNMEKLTFY 7 8.7 1.0043 -0.80421 0 7.70113 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RC80 A0A8C0RC80_CANLF BRCA2 and CDKN1A-interacting protein Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634]; spindle pole [GO:0000922] AFGPGHEDEDEEESDEDED;DEDEEESDEDEDGDDESVD;EDEEESDEDEDGDDE;EDEEESDEDEDGDDES;GPGHEDEDEEESDEDEDGDDE;PGHEDEDEEESDEDEDGDDES 6 9.7 0.99137 -0.0041962 0 0 8.8088 4.49269 0 4.97852 10.8369 0 0 0 0 4.88962 0 0 0 A0A8C0RC84 A0A8C0RC84_CANLF TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signaling cassette [GO:0141124]; protein ubiquitination [GO:0016567] cell cortex [GO:0005938]; lipid droplet [GO:0005811]; nucleus [GO:0005634] tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] APVPQRDVPPYDSS;CENSCGSSQSESDCC;GVGAPDLI;QDHQIRELTAKMETQS;VHLVVLAAAEEG;VLQRRLPLEGVVAGQEGLLGG 6 8.9 1.0029 -1.7429 11.8332 0 0 10.9951 6.49205 0 0 13.7115 10.0565 0 0 0 0 0 0 A0A8C0RCA1 A0A8C0RCA1_CANLF Lysosomal cobalamin transport escort protein LMBD1 (LMBR1 domain-containing protein 1) LMBRD1 Canis lupus familiaris (Dog) (Canis familiaris) gastrulation [GO:0007369] lysosomal membrane [GO:0005765] cobalamin binding [GO:0031419] SLTLIGMLAAITYTAYG;VFRKFFRTRTIILSLDKH 2 6.9 0.97854 0.048313 0 0 11.0076 0 9.14962 0 0 0 0 0 0 0 0 0 0 A0A8C0RCF1 A0A8C0RCF1_CANLF AFP-like domain-containing protein NANS Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] HKRHLEFSHEQYRELQ;LEKTAKKG;TLDMLTVKV;VKVGEPKG 4 10.6 1.0025 -1.7951 0 0 0 6.21987 0 0 7.32715 10.5071 0 8.89996 0 0 0 0 0 A0A8C0RCH0 A0A8C0RCH0_CANLF Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" HVGRLVTRDAFNSGKAD;YDNSLKIVSNASCTTSCL 2 21 0.99012 -0.21696 0 0 0 0 0 0 0 0 0 0 0 0 6.35685 0 0 A0A8C0RCH7 A0A8C0RCH7_CANLF LRRNT domain-containing protein PODN Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] EEDEEDEDDEEEEEER;GVLLVLLLLPP;GVLLVLLLLPPQL;RGQVEEEEDEEDED;TMARSGVLLVLLLLPPQLQLGPVG;VLLVLLLLPPQ 6 7 0.67797 0.28185 0 3.58568 0 3.0077 0 7.45294 0 0 4.27873 0 3.03791 6.97694 0 4.13233 0 A0A8C0RCJ3 A0A8C0RCJ3_CANLF Queuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Queuosine-nucleotide N-glycosylase/hydrolase) Canis lupus familiaris (Dog) (Canis familiaris) tRNA-guanine transglycosylation [GO:0101030] hydrolase activity [GO:0016787] HAGGCAEG 1 2.1 1.0041 -1.1044 0 0 7.5552 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RCK1 A0A8C0RCK1_CANLF Myomegalin Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; regulation of Golgi organization [GO:1903358] centrosome [GO:0005813]; Golgi apparatus [GO:0005794] molecular adaptor activity [GO:0060090] LIQDQARELTHLRQK 1 4.3 0.98922 -0.26403 10.6943 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RCL2 A0A8C0RCL2_CANLF Protein tyrosine phosphatase mitochondrial 1 Canis lupus familiaris (Dog) (Canis familiaris) phosphoprotein phosphatase activity [GO:0004721] ALPLRNMTRRLV 1 8.8 0.94488 0.05044 0 7.78509 0 0 0 0 7.41193 0 0 0 0 0 0 0 0 A0A8C0RCP2 A0A8C0RCP2_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GVHYWELTV;MLGKDDKA;RSRRRRRRRRRRRPRCWRRQVG;SESPQSRRASGSG 4 6.4 0.97269 0.046699 8.08725 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RCP7 A0A8C0RCP7_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGRAALY;PSRLCFPGE;TWSIRFYF 3 4.7 1.0032 -1.9246 0 0 0 0 0 8.58406 0 0 0 0 0 0 0 0 0 A0A8C0RCP9 A0A8C0RCP9_CANLF Inner centromere protein Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819] ICNVDNKDLVWLE;KKEEEQERLRKVAEAKRLAEQREQE;NVDNKDLVWLE;PVEAAEPEVRQAS;QERQLAEQREQERRKEQERLQEEQ;RQKVEEDKRRRLEEVKLKREERLR 6 11.7 0.91474 0.1106 9.73045 0 0 0 0 0 7.17263 0 0 0 0 0 0 0 0 A0A8C0RCR2 A0A8C0RCR2_CANLF Dermokine Canis lupus familiaris (Dog) (Canis familiaris) cornified envelope assembly [GO:1903575] GVGNAISQGVEE;SSSGGGGS;SSSSGSGGGSGS 3 4.5 0.99236 -0.1785 0 0 9.78423 0 0 0 9.5996 0 0 0 0 0 0 0 0 A0A8C0RCS5 A0A8C0RCS5_CANLF Rap-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] nucleus [GO:0005634] GTPase activator activity [GO:0005096] ALLKYIVIQV;DHMEQKDL;EHTRDYRRGIIPTEF;EVHIVWSEHTR;GDDDLLTSLK;GVYKTVVHALSKPKANVSPQ;IKARVIVIRWLV;LVSCIQIRSEESIP;PDDLEISEFPSE;PEPLHSPDSERSS;PLNSDIGSSNVNVPD;RGIIPTEFGDVLII;TFRPSTESVQFYNPLEN;TSSASNLHTSSNSFTEL;YYLPYIFPNICKENSLYH 15 7.6 1.0033 -2.1037 0 14.8962 0 8.06167 3.88548 10.8779 11.1731 11.3418 6.87036 11.1399 0 8.64184 4.02201 4.45707 10.0154 A0A8C0RCT2 A0A8C0RCT2_CANLF Methyltransferase like 21C Canis lupus familiaris (Dog) (Canis familiaris) VINPSIHTVAPMADALLDQ;VIQESIESYGAVVWPG 2 10.1 0.9354 0.09376 0 0 0 0 0 0 0 11.7833 0 0 0 0 0 0 0 A0A8C0RCT5 A0A8C0RCT5_CANLF Laminin subunit alpha 4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] ADNLTNWSQNLQ;CAVCNCGG;DIYIGGAPPEILQSRT;EEHELTSEEISE;EGGFNFRTLQ;IFYVSDQEE;IKVQSADKQYNDG;LPPTGAAWNIKGPIYLGGVAPG;LVHGHSVNGEYLNVHMKK;NAKLSDLQESL;PGRAVKNV;SGECMPCVCNGNSD;VHLEDTSKRAQINDAKYHEISI;VLAGRAHPCVP;VYNLGTKD 15 10.7 0.99442 -0.56244 0 0 0 0 0 0 8.72096 0 0 0 0 0 0 0 0 A0A8C0RCW8 A0A8C0RCW8_CANLF A-kinase anchor protein 7 RI-RII subunit-binding domain-containing protein AKAP7 Canis lupus familiaris (Dog) (Canis familiaris) PRAGDSAGAMGQLCCFPF;PSPPVLLPPPLSSL;VLQRYTENRPSWPSGA;VPSAPGGP 4 16.7 0.98987 -0.26571 8.42496 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RCZ1 A0A8C0RCZ1_CANLF WW domain-containing protein FNBP4 Canis lupus familiaris (Dog) (Canis familiaris) DWQEVWDENTGC;GADTSEKIDENSD;IDSTLANFLAEIDA;LRALEEGDGSVSGSSPCSDISQPAS;LVSGMAERNANFE 5 7.5 0.98717 -0.37859 0 0 0 11.9132 0 0 9.46297 0 0 0 8.25687 0 0 10.5064 0 A0A8C0RD12 A0A8C0RD12_CANLF IGFBP N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] LLTDGCGCCEVCARQ;LPLPRPAPAPLL;RPAEPAERRGRPLCRWPCE;TDGCGCCE 4 7.6 1.0022 -1.2984 0 0 0 0 0 0 7.87774 0 0 0 0 4.66072 7.28448 0 0 A0A8C0RD18 A0A8C0RD18_CANLF Mitochondrial inner membrane protease subunit 2 Canis lupus familiaris (Dog) (Canis familiaris) protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465] mitochondrial inner membrane peptidase complex [GO:0042720] serine-type endopeptidase activity [GO:0004252] TFYKKIGT;VLGPGNVEGISKLQHNCICSKV 2 23.4 0.98943 -0.21621 0 0 0 9.04171 0 0 11.6028 0 0 0 0 0 0 0 0 A0A8C0RD38 A0A8C0RD38_CANLF Delta-like protein JAG2 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509]; Notch binding [GO:0005112] CDAYTCSNGGTCYDS;DCNSCHCMD;DLCDPSPCQNGA;DLDLCDPSPCQNGARCYNLQGD;EDCNSCHCMDGHRD;GACCDGDGRTTRAGGCGHDECDT;GDYYCACPDDVGGKNCSV;GVCIDGINWFR;HVAHMELQIRVRC;NSCHCMDGHRDC;RLTWAAGGGGQSPGRP;VEAWDWDND;VEDCNSCHCMD;VGSGDSFSCIC;VNDFYCACDDGW;YHCVCPDGYSGKNCERAEHA 16 14.8 0.93426 0.099039 0 0 0 0 0 0 0 0 0 7.79325 8.46744 0 0 0 0 A0A8C0RD40 A0A8C0RD40_CANLF UDENN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] guanyl-nucleotide exchange factor activity [GO:0005085] DALLALLDPL;HVYIPVLPPHLLDY;LIVCSKLSTLTAC;VPNLFGQMPMGAHTSPLQ 4 5.4 1.0027 -1.3538 0 0 0 10.5181 0 11.1788 0 10.1649 0 0 0 10.5569 0 0 0 A0A8C0RD44 A0A8C0RD44_CANLF Phosphatidylcholine translocator ABCB4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ELMKKEGVYFK;ESKELDENV;FYDPVAGTVL;KKKMKRMKLI;SEMIAVFGPGDDEVK;VGDKAPNG 6 5.1 0.99793 -3.3328 7.45984 0 0 0 0 0 0 6.94416 0 0 9.15555 3.49531 9.72479 0 3.01148 A0A8C0RD56 A0A8C0RD56_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] signaling receptor activity [GO:0038023] ALPPSTQRL;DDYWGGYGGEDQRGEQTCP;PSTLYRDLPAE 3 10 0.9863 -0.42561 0 0 0 0 0 0 0 7.7066 0 0 0 10.5113 4.53356 0 0 A0A8C0RD64 A0A8C0RD64_CANLF Zinc finger protein 706 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] KATFIYACTICRTRMPDAKTFQ 1 31.9 0.98343 -0.25548 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0681 0 A0A8C0RD93 A0A8C0RD93_CANLF Carboxylic ester hydrolase (EC 3.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) carboxylic ester hydrolase activity [GO:0052689] GVVTARYHRDAGAPVYF;PVLATCGG 2 4.6 1.004 -1.1044 0 0 11.3608 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RDB0 A0A8C0RDB0_CANLF Transcription factor 4 TCF4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERLSYPSHSSADINSSLPPM;GGLFTVVLWRCRQRKFE;NHAVGPSTAMPGGHGDMHG 3 9.5 0.98539 0.046227 0 0 0 0 0 7.06555 0 0 0 0 0 0 0 0 0 A0A8C0RDB8 A0A8C0RDB8_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP4A Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; sodium ion export across plasma membrane [GO:0036376] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] AAKNAADMILLDDNFASI;PYWENHHLQDL;VLCPLQNDHQ;WREAFQTAYLSL 4 4.7 1.0021 -0.74114 0 0 0 0 0 0 10.3077 0 11.881 0 0 6.54099 0 0 6.03518 A0A8C0RDB9 A0A8C0RDB9_CANLF HAUS augmin like complex subunit 5 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] HAUS complex [GO:0070652] EVAGRRQLLLQE;FLQDQQSFRCW;VGTLVAQRGPLLKEQQILTRR 3 7 0.98687 -0.23101 3.9279 0 0 0 0 0 0 0 0 8.20838 0 0 0 0 0 A0A8C0RDD4 A0A8C0RDD4_CANLF "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) calcitriol biosynthetic process from calciol [GO:0036378] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" AALVRDVAAEFYKFGLEGTAA;GRLCRDWDQMFAFAQQHVERREA;SRLGCLEAQVPPDTDA;VGSGAHLTYF 4 13.8 1.0022 -0.76338 0 7.90304 0 0 8.09856 0 0 8.20203 0 0 0 0 0 0 0 A0A8C0RDE6 A0A8C0RDE6_CANLF 3'-5' exonuclease domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] ARLEALLLL;EAGHPDLHGPSAHP;ESPPVLVE;GSQDPFPFLQALQKLWSTR;GVDLEWRPS;IFQLQDADQSPLL;KADPSEDLQDAG;PLGWAEAGHPDLHGPSAHPR;PRVLQIASRTPR;PSTAPQPHWPGPL;PVGSQDPFPFL;VGGRVFLLDLPLL 12 13.4 0.99874 -3.0278 7.31587 10.2505 0 7.38128 0 0 5.71122 0 0 0 9.39558 4.83724 0 0 10.4217 A0A8C0RDF4 A0A8C0RDF4_CANLF Stress-induced-phosphoprotein 1 (Hsc70/Hsp90-organizing protein) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] Hsp90 protein binding [GO:0051879] HVLYSNRSAAYA;VNELKEKGY 2 4 1.0047 -0.80421 0 0 0 0 0 0 10.2633 0 0 0 0 0 0 0 0 A0A8C0RDH4 A0A8C0RDH4_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC18B1 Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] HIKSQLWLLVLILVL;LITLPKVALIAFVINSL 2 7.8 0.9392 0.1001 0 0 0 5.56505 0 0 0 0 0 0 0 4.35262 0 0 0 A0A8C0RDI0 A0A8C0RDI0_CANLF Solute carrier family 35 member F6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GASARDRP;MFLGEFSC;RHNVHPLRAVGTEG 3 6.4 1.0019 -1.3065 6.65549 0 0 0 0 0 0 0 0 9.89892 0 0 13.1738 13.3108 13.2355 A0A8C0RDI8 A0A8C0RDI8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) RPS6KC1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine/threonine kinase activity [GO:0004674] DSRRFPELAH;EVEDSCDSDAIERM;LLFTDQTEDLAKEEL;PPLHDSRRFPEL 4 3.6 1.0014 -0.70228 14.3086 14.188 0 0 0 0 0 14.1553 0 0 0 0 0 0 8.69118 A0A8C0RDJ1 A0A8C0RDJ1_CANLF DEAF1 transcription factor Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; metal ion binding [GO:0046872] ASCTCAACCDDMTLSGP;CTCAACCD;LSRDEDSEEDGDS;NPHAASCTCAACCDDMT;RASQPRALGPGAQKAALFPRLTG;SCTCAACCDDMT;TLFKSRLG;VLSRDEDSEEDG 8 10.3 0.97985 0.046263 0 0 8.09032 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RDJ5 A0A8C0RDJ5_CANLF SEC14 like lipid binding 5 Canis lupus familiaris (Dog) (Canis familiaris) ADRPCSGGPGPAPET;EDVLTALHSPGPK;LGSEVLRESRSADGA;PENEEWTCFEQ;QLILEICGHR;TDGDKLDADYIERYLGR 6 11.2 1.0029 -1.3288 5.85855 0 0 0 0 0 0 0 0 0 0 0 10.1795 0 7.42694 A0A8C0RDL0 A0A8C0RDL0_CANLF "Double-headed protease inhibitor, submandibular gland" LOC111092171 Canis lupus familiaris (Dog) (Canis familiaris) serine-type endopeptidase inhibitor activity [GO:0004867] DIECTEYS;DIECTEYSDMCTMDYRPLC;QDTACDIECTEYSDMCTMDYRPLCG 3 23.6 1.0023 -1.0194 0 0 0 0 7.57675 0 0 0 0 0 0 0 0 7.56818 0 A0A8C0RDM2 A0A8C0RDM2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] DIVMTQTPPSL;GEPASISCKASQSLLHSNGNTYLN;MTQTPPSLSVSPGEPAS;VMTQTPPSLSVSPG 4 36.8 0 10.307 12.4674 13.0172 12.3796 6.39103 10.0869 0 12.6995 12.8024 12.9517 12.8703 12.7941 13.1679 0 1.74597 9.96622 A0A8C0RDM6 A0A8C0RDM6_CANLF DNA polymerase zeta catalytic subunit (EC 2.7.7.7) REV3L Canis lupus familiaris (Dog) (Canis familiaris) translesion synthesis [GO:0019985] nuclear lumen [GO:0031981]; zeta DNA polymerase complex [GO:0016035] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] DDDDDDNDDYYVSYS;EDDDDDDNDD;EDDDDDDNDDY;EEDIPSVPR;EEIMATLLDHDLSE;EKGEDDDDDDNDDYYVSYSSP;FFGNTKNPQN;IRSSTLSPELFEKSSIDNNENH;PQKFLSDAVQDLF;QAIWEDEKQRRRNR;QIGGNPGL;RLDIEAQIGGNPGLQA;SEGNEKGNSTALNSLFPSSL;SPNGIAFVKPSVR;STEEDDSSSEEEMEWS;TEEKMELYKKLAPLKD;VAADILNRLDIEAQ;VLHQRFPLFTFRVLSDWFD;VTPSVQQRSQMRAPQ 19 7.7 1.0038 -2.0297 8.35755 10.789 7.32823 0 0 0 0 9.4204 11.7566 8.62819 8.72863 0 11.985 10.9267 0 A0A8C0RDM9 A0A8C0RDM9_CANLF TATA box-binding protein-associated factor RNA polymerase I subunit D (TATA box-binding protein-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668] LVDKRNILKKLLRLK;LVDKRNILKKLLRLKR;SLSPIEESETVEEAAT;SSFEPRPLTLKAIFERFKKKKRKKR 4 25.8 0.79952 0.20962 0 5.96419 0 0 0 0 0 0 8.30191 4.76182 0 0 0 0 0 A0A8C0RDP9 A0A8C0RDP9_CANLF Paired domain-containing protein PAX5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PGLLGSPYYYSAAA;VSKILGRII 2 7.9 1.0035 -0.80421 0 0 3.33571 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RDQ9 A0A8C0RDQ9_CANLF Ubiquitin associated protein 1 UBAP1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] AMKQKVLSP;GFSLPDCLQVVREVQ;GGYGDGLA 3 5.6 1.0016 -1.3166 0 0 0 0 0 0 11.1001 0 0 0 9.29616 2.82853 0 0 0 A0A8C0RDT1 A0A8C0RDT1_CANLF WD repeat domain 3 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] PEPKKSKGSSPEIQDTHEP;SELEESLL;SLLDCTVKIFY 3 4.3 1.0028 -1.3526 0 9.43089 5.74338 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RDT6 A0A8C0RDT6_CANLF Nucleolar protein 10 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] AVGTSTGQ;MLLTANETPKMGIYYIPV;SEKRKKKLRLL;VGKAWQGGLCKNMVL 4 6.7 1.0018 -0.9667 0 0 0 0 0 0 3.97865 0 0 0 0 0 9.29788 10.5401 9.13945 A0A8C0RDU3 A0A8C0RDU3_CANLF GB1/RHD3-type G domain-containing protein ATL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VKYSGEFREIGTMIDQIAETLWEQ 1 4.3 0.95056 0.053007 0 0 9.5919 7.74409 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RDX2 A0A8C0RDX2_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASGPPPAG;LSALHPAIFGHL 2 2.4 0.99023 -0.26198 0 0 0 0 0 0 0 0 0 0 0 11.9055 0 0 0 A0A8C0RDZ3 A0A8C0RDZ3_CANLF Dedicator of cytokinesis 4 DOCK4 Canis lupus familiaris (Dog) (Canis familiaris) cell chemotaxis [GO:0060326]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] ASPARHTTSVS;DETYRELFNSILLKK;KEHLHLAIIQNFDRG;LNENFDYKIWDSYFYLAVIFINQLC;LYVRNEGDLFHRLW;PIFHDMMDWEQRR;PRPLPRKVS;QELLMSVRFFLSQ;RDWGTMWKQLYVR;SDRPLREFLTYPM;VDGKKIGC 11 7.8 0.98925 -0.508 0 0 0 0 9.31145 0 0 10.3965 9.68154 0 10.6459 8.39288 0 0 0 A0A8C0RDZ6 A0A8C0RDZ6_CANLF Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.53) (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (mRNA N(6)-methyladenosine demethylase FTO) (tRNA N1-methyl adenine demethylase FTO) Canis lupus familiaris (Dog) (Canis familiaris) DNA alkylation repair [GO:0006307]; regulation of multicellular organism growth [GO:0040014]; RNA repair [GO:0042245] cytoplasm [GO:0005737]; nuclear speck [GO:0016607] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931] DDEFYQQWQL;IVSELRGAPTP;VLHEVRREGVPVEQRNE 3 6.1 0.9835 0.035491 7.20379 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RE08 A0A8C0RE08_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; translation [GO:0006412] Golgi membrane [GO:0000139]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735]; sulfotransferase activity [GO:0008146] EVICNSMAKTLQTALQPPDWLQGHY;PAAAPRALLSPWPRRPGRRWP;VGAAPAAA 3 9.8 1.0025 -1.021 6.70888 0 0 9.05493 0 3.40762 0 0 0 0 0 0 0 0 0 A0A8C0RE11 A0A8C0RE11_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASGSWEQKPELLRKLE;GFYSCGIY 2 10 1.0039 -1.0552 0 0 0 0 0 0 10.3933 0 0 0 5.9842 0 0 0 3.97884 A0A8C0RE16 A0A8C0RE16_CANLF Transmembrane protein 201 TMEM201 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637] MEHLNHVVSS;NRNCWDCPHCEQYNGFQE;PTQPQQWVSSQVLLCRR;VTACAAAG 4 13.5 1.0044 -1.088 0 0 0 0 0 0 0 10.0007 10.2997 0 0 0 0 0 10.123 A0A8C0RE19 A0A8C0RE19_CANLF Protein CASP CUX1 Canis lupus familiaris (Dog) (Canis familiaris) intra-Golgi vesicle-mediated transport [GO:0006891] Golgi membrane [GO:0000139]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GAAELGLEKIPEPI;GGQGCLHL;NVGSMFQYWKRFDLQQLQRELDA;PGVLGQPKSHSRLLATS;SNSDLSGRCA 5 10.2 1.0022 -0.76748 0 0 0 0 0 0 8.83659 5.46757 8.37968 0 0 0 0 7.67497 0 A0A8C0RE26 A0A8C0RE26_CANLF Family with sequence similarity 110 member A FAM110A Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] cell cortex [GO:0005938]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922] TPGWGAPSRLGRGH;VANTRQEPVQ 2 5.7 0.99357 -0.031289 0 0 0 0 0 0 0 0 6.7226 0 0 0 0 0 0 A0A8C0RE30 A0A8C0RE30_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AGILLFVIIFLGVVLVMKKRK;DEPYSTCG;GVVLVMKKRKLAKK;IDGYHRPNHY;MQETIYDFWRMV;VEYCTASGSW;VLVMKKRKLAKKRKE;VTRCHSYNLTVH 8 5.3 1.0022 -1.2989 12.0001 6.44087 0 6.3474 0 0 3.57313 0 0 11.5057 0 0 9.14287 0 0 A0A8C0RE51 A0A8C0RE51_CANLF DNA helicase (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] AAGEGGMGGARGGGAGA;AKGGGGRG;CRAKCGPRLSAEAA;CWFQLLFMCIIRFQS;EEEFRRLAALPNVYEVISKSI;GFTFKYRDELKRHYNLGEYWV;HYNLGEYWVEVEMEDLASFDE;MGGARGGG;PIGVYTSGKGSSAAGLTASVMRDPS;SFGGDPAA 10 13.9 1.0005 -2.7823 0 8.48297 4.46689 9.63021 0 0 8.61117 9.9571 8.12324 0 7.59156 9.4176 10.6872 0 10.8693 A0A8C0RE52 A0A8C0RE52_CANLF "Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (Nucleoside diphosphate-linked moiety X motif 1)" Canis lupus familiaris (Dog) (Canis familiaris) DNA protection [GO:0042262] nucleus [GO:0005634] "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; metal ion binding [GO:0046872]" EESGLTVDTLHKVGQIMFE;HLQAPSPVPSAHHSPHL;RPQWFQLDQ 3 9.8 0.98538 0.046227 0 4.20625 4.24891 5.00612 0 0 0 0 0 0 4.02281 0 0 4.23519 0 A0A8C0RE72 A0A8C0RE72_CANLF Centromere protein J C-terminal domain-containing protein LOC484082 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814] DGREETVFPDGTVV;ERPAAFVDEQATHQSSQSL;KEDSPAADKNGTRSLPC 3 13.1 0.98781 -0.48759 0 0 9.45744 0 0 0 0 0 0 8.65055 0 0 0 0 0 A0A8C0RE80 A0A8C0RE80_CANLF Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) EVL Canis lupus familiaris (Dog) (Canis familiaris) actin polymerization or depolymerization [GO:0008154]; positive regulation of actin filament polymerization [GO:0030838] cell projection [GO:0042995]; cytoplasm [GO:0005737]; stress fiber [GO:0001725] actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124] QELSWDQHLVAAWPRRRD;SGGSSPSGTS 2 6.2 0.97961 0.048313 0 0 0 0 0 0 0 8.01207 0 0 0 0 0 0 0 A0A8C0RE81 A0A8C0RE81_CANLF SOSS complex subunit C (SOSS-C) (SSB-interacting protein 1) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (Single-stranded DNA-binding protein-interacting protein 1) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; response to ionizing radiation [GO:0010212] SOSS complex [GO:0070876] RKLLVLLKISTLPVPLS 1 14.7 0.98559 0.046227 0 6.57725 0 0 0 0 5.44629 0 0 0 0 0 0 0 0 A0A8C0RE99 A0A8C0RE99_CANLF Plakophilin 3 PKP3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] LLYFDGLRKLVFIKKKR;LRKLVFIKK;RRLRELPLT;RWAWDGDRDPLAH;VNIIAVLNNLVVA 5 6.4 0.93775 0.071339 0 0 0 0 7.5509 0 0 0 0 0 0 0 0 0 0 A0A8C0REB2 A0A8C0REB2_CANLF Histone-lysine N-methyltransferase (EC 2.1.1.364) KMT2A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; regulation of DNA-templated transcription [GO:0006355] histone methyltransferase complex [GO:0035097] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; zinc ion binding [GO:0008270] ALWSAEVFEDD;CCLTSCTSN;DIVSPPSPDRPHSQTSGS;DPSVFSPLNKSET;IVSPPSPDRPHSQ;LKKRPISRLQTRKNKKLA;LLAWSWCLN;LPESVAYTCVNCTERHPAEWRLALE;LTRNSSTPG;NFSSPLML;PPEYNPNDEEEEEVQLKSARR;PSEAHSRIF;QQATKIKKLRAGKLSPLKSKFK;RNIDAGEM;SGSCFYHVISKVP;TAPSLEKEKT;VGCCLTSCTSNYHF;VIFAMRKIYRGEELTY;VISSGGDERLASHNLFREEEQ 19 6.1 0.99686 -4.3542 12.2007 11.3268 8.30154 0 13.0105 0 10.2894 0 0 8.48651 9.47873 8.53056 9.42536 8.66534 8.33838 A0A8C0REC0 A0A8C0REC0_CANLF 40S ribosomal protein SA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181]; ribosomal small subunit assembly [GO:0000028] 90S preribosome [GO:0030686]; cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] LAREVLLMRGTNL 1 2.9 0.99203 -0.27051 0 0 0 0 0 0 10.4925 0 0 0 0 0 0 0 0 A0A8C0REC9 A0A8C0REC9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLAALGAHVGLL;GVGLLARVRALVLRERREVAEALL;LALAAVKGLLAGVHAQVVHQ;PAHAHAHQP;PRTSTPPHA;VGLLARVRALVLRERR 6 11 1.0011 -0.63829 0 0 9.05001 0 0 3.40966 0 10.109 0 9.34465 4.52199 0 0 0 0 A0A8C0RED0 A0A8C0RED0_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) BAP1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cysteine-type deubiquitinase activity [GO:0004843]; semaphorin receptor binding [GO:0030215] EDDYEDDEDDD;ELQVFKVPTPI;LTEGGKGSSPCSRPS;QQYSDDEDDYEDDEDDDVQNT;QYSDDEDDYEDDEDDDVQNT;SDDEDDYED;SDDEDDYEDDEDDDVQNTNS;VLSPLALTEGGK;YSDDEDDYEDDEDDDVQNT;YSDDEDDYEDDEDDDVQNTN 10 5.1 1.0011 -0.64369 8.94043 0 8.81644 0 5.55995 8.12443 3.49288 8.32409 9.86799 0 4.56444 0 0 8.21344 7.4422 A0A8C0RED5 A0A8C0RED5_CANLF Rho GTPase activating protein 33 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] phosphatidylinositol binding [GO:0035091] EDRSWWRGK;ERLVRVHDVIQ;HRCIFDRRFSCLPEL;LDRGENLYYE;MAAQLPCSVPSQAPTPGFFSSAPR;VPQVLRCCS 6 6.9 0.97373 0.041303 8.68489 9.10119 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RED8 A0A8C0RED8_CANLF Fringe-like glycosyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of Notch signaling pathway [GO:0008593] membrane [GO:0016020] O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829] AAGDLDLAPQGDGNVV;PACVCSVP 2 3.9 0.98973 -0.21397 0 7.30861 9.83626 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0REF3 A0A8C0REF3_CANLF TRPM8 channel associated factor 1 TCAF2 Canis lupus familiaris (Dog) (Canis familiaris) KVSKKIPKIPLQVGYR;QACGVQAQVQSDLGPPLG;VGWLCASPGAPTGVHPSLE;VTSVAGVYFTD 4 27.1 0.95557 0.049233 0 0 0 0 0 0 0 0 9.2122 0 0 0 0 0 0 A0A8C0REG9 A0A8C0REG9_CANLF Ral transcription factor IIIC subunit 3 GTF3C3 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase III [GO:0006383] ASMLGENEDDEEEEEEEEEEEEET;DTLLTMLAM;ELYISNKHYDKALE;GENEDDEEEEEEEEEEEEETPE;IRGPCQESFYNLGR;MCMEIIRQ;NEDDEEEEEEEEEEEEETP;QPTAGDVFVLE;YIRVMVMENVNKP 9 11.2 1.0038 -1.6764 0 6.44812 0 0 0 0 10.0031 0 10.9694 4.32222 0 12.149 4.69477 9.38504 0 A0A8C0REH6 A0A8C0REH6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EREYEMKRLNHLKCQENVAEEIQ 1 22.8 0.99303 -0.28188 0 0 0 0 0 0 0 0 0 0 0 0 10.145 0 0 A0A8C0REH9 A0A8C0REH9_CANLF "GTP 3',8-cyclase (EC 4.1.99.22)" MOCS1 Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] "4 iron, 4 sulfur cluster binding [GO:0051539]; GTP binding [GO:0005525]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]" AEELSRRRQFLREHAV;GTQSASSGAQRCLYG 2 8.1 0.9871 -0.2305 0 0 0 0 0 0 0 9.54873 0 0 0 0 0 0 0 A0A8C0REK5 A0A8C0REK5_CANLF Vinculin (Metavinculin) VCL Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; podosome [GO:0002102]; sarcolemma [GO:0042383] actin filament binding [GO:0051015]; structural molecule activity [GO:0005198] AGNISDPGLQ;ALIQCAKDIA;ATSIARRANRILLVAKR;EVVETMEDLVTYTKNLGPG;VGFPVPPDMEDDFEPE 5 6.3 1.003 -0.73134 5.38933 0 0 5.35864 0 0 0 0 0 10.1968 0 0 0 7.20594 9.83772 A0A8C0REL2 A0A8C0REL2_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] PELMNKYVGESE;SSGLGLVEVTELKCSFES;VGAKCNTDIFYFISST 3 5.8 1.0023 -0.74095 0 9.61504 0 0 0 10.259 10.853 10.2458 0 0 0 0 0 0 0 A0A8C0REL8 A0A8C0REL8_CANLF Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein sorting-associated protein 24) Canis lupus familiaris (Dog) (Canis familiaris) endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to vacuole transport [GO:0045324]; protein transport [GO:0015031] ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771] FESMDDQEEMEEAAEME;GIIEEMLEDTFESMDDQEEM;VWENPGEAAQRADIQR 3 17.3 0.86828 0.14367 0 0 0 0 8.67804 0 5.60641 0 0 0 0 0 0 5.85237 0 A0A8C0REQ7 A0A8C0REQ7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] IETRRTVEQIK;IIPILLKLFGKIKR;IIPILLKLFGKIKRDGVL;PSICCLQETHFRQ 4 3.3 0.86457 0.14477 0 0 0 6.88203 9.40122 0 0 0 0 0 0 0 0 5.77497 0 A0A8C0RES0 A0A8C0RES0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; fibrillar center [GO:0001650]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EDGGGGGG;GGGGGGGG;NGTAGGGG 3 7.8 1.0033 -1.1044 0 0 0 0 0 0 6.55061 7.02303 6.33129 0 0 0 0 0 0 A0A8C0RET1 A0A8C0RET1_CANLF Olfactory receptor OR2A5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;LFNPMLNP;LVHVILILRLPFCG 3 11.3 0.985 -0.44525 0 0 0 0 0 0 0 0 0 0 0 0 0 4.23281 0 A0A8C0RET4 A0A8C0RET4_CANLF Tripartite motif-containing protein 54 TRIM54 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] microtubule [GO:0005874]; Z disc [GO:0030018] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GGRGGGGG;NKGLMCSD;PQMALYLQ;SLCKVFGAHKDCEVAPLPTI 4 7 0.98756 -0.4618 9.13668 0 0 0 0 0 0 0 9.02862 0 0 0 0 0 13.8895 A0A8C0REU5 A0A8C0REU5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) INIYFLKLKKK;KLKKKVHWKKR 2 3.8 0.99026 -0.26645 0 0 0 0 0 3.09795 0 0 0 0 0 0 0 0 0 A0A8C0REV1 A0A8C0REV1_CANLF Rho guanine nucleotide exchange factor 5/35 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ELLPPHPSSVPGASH;LMCLLDAWGLE;LVASEVSSPCDLFPDTCYP 3 8.8 0.98484 -0.24657 0 0 0 0 0 0 0 0 0 0 0 0 0 9.00966 0 A0A8C0REV4 A0A8C0REV4_CANLF Glycoside hydrolase family 65 central catalytic domain-containing protein PGGHG Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824] GALGFRDSPRREEG;RVAMGSWPITV;VGWMELKDPRRAQ;WRMRLEAPAETGRELTETFVL 4 8.6 0.93784 0.063779 8.75689 0 0 0 0 9.58509 12.4691 0 0 0 0 0 0 5.1194 0 A0A8C0REX3 A0A8C0REX3_CANLF Ig-like domain-containing protein IGSF11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EEEEEIPNEIREDDLP;GGTYALVGTTFLVGSSGVH 2 7.4 0.99367 -0.12009 0 0 6.56578 9.75661 0 0 0 0 0 0 0 0 0 0 0 A0A8C0REY4 A0A8C0REY4_CANLF FAT atypical cadherin 4 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CELNSYGFEELSYMEFP;CVPPGDCA;DGLQSSDMRINITV;DLNSNISYLITTGD;DSDSHESFTCSEMEYDREKPM;EGACTHSP;EKTPTYSLTVQ;EVEYLISNENHF;EVTPQYQLLVEVED;FTPVTKNVKVGTKLIKVT;GSGTYKLTT;GVNSLEIKFRTRSENGILIH;ISIEAASPRGSE;IVDRYSGDLRVASALVPSQ;KEERVSLKV;LLSTGPATNYF;LSASGELRVIQSLD;MDADEGANALVTYTI;NGASEVTFSVHVKDG;PAPFSKSSTFYRNSP;PLNREDTDRYRIRVSAHDSGWTVS;QPALSSSTEVVVMVLD;QSPMPLGASSL;RRGHVESH;SIVSGNGLGW;SSVNYCECNPCFNGGSCQ;SVASSLISDLNQNFL;SVNYCECNPCFN;TELTIILQ;TTIMAADPDEGANGEV;VGSSVLQV;VSNVAVSDD;YIKSELDRELQD 33 8.7 0.99706 -7.2098 10.6578 9.64064 10.9638 10.401 8.29627 9.85014 9.97699 13.5498 10.7114 0 11.3402 11.9308 10.4459 10.5234 10.0765 A0A8C0REY7 A0A8C0REY7_CANLF SET nuclear proto-oncogene Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDEEE;DDDDEEEEEGLE;DMDDEEGEGEEDDDDDEE;DMDDEEGEGEEDDDDDEEE;DMDDEEGEGEEDDDDDEEEEEGLED;EDDDDDEEE;EDDDEGEEG;GDEDEGEEDEDDDEGEEGEED;IDEEGDEDEGEEDEDDDEGEEGE;IDEEGDEDEGEEDEDDDEGEEGEED;LEDIDEEGDEDE;VPDMDDEEGEGEEDDDDDEEEEEG;YLVPDMDDEEGEGEEDDDDDEEEEE 13 18.6 0.98733 -0.36428 8.20506 0 9.57249 0 5.47207 7.06985 0 0 0 0 5.82594 0 8.18428 9.47782 5.92655 A0A8C0REY9 A0A8C0REY9_CANLF PPM-type phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] ANTLHSCLRRQLE;FLRGSGSGP;LRRQLEAVVEGM;VGPPATSA;VLDTNIQL 5 6.6 1.004 -1.1044 9.67941 9.87877 0 0 0 0 10.133 10.42 10.4589 0 0 0 0 0 0 A0A8C0REZ9 A0A8C0REZ9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AGTKVHGLGHTQAPPKYPEE;PVCSLFPQRP 2 7.8 0.99441 -0.56143 0 0 0 0 0 0 9.92075 0 0 0 0 0 0 0 0 A0A8C0RF09 A0A8C0RF09_CANLF Dynein heavy chain domain 1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959] PDTSLLES 1 1.3 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 11.8411 0 0 A0A8C0RF11 A0A8C0RF11_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APSTRHSAPGT;AYVFITYDDYDHFFEDV;HVMCMHRTVQKE;ILLLVFVTEVVVV;PAPSTQHPALSTQHL;TGTQHSAPSTRH 6 10.1 1.0037 -1.0717 0 0 0 0 8.35848 0 10.8032 0 0 0 0 0 0 0 0 A0A8C0RF14 A0A8C0RF14_CANLF Ribosomal RNA-processing protein 8 (EC 2.1.1.-) RRP8 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose starvation [GO:0042149]; energy homeostasis [GO:0097009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; methylation [GO:0032259]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; rDNA heterochromatin formation [GO:0000183]; regulation of G1 to G0 transition [GO:1903450]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364] cytosol [GO:0005829]; eNoSc complex [GO:0061773]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553] methylated histone binding [GO:0035064]; methyltransferase activity [GO:0008168] DQAPATAP 1 1.8 1.0038 -1.1044 0 0 10.7093 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RF17 A0A8C0RF17_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MINK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AAFPASHEPDPAV;AMDYSSSSEEVESSEDEDESNGEPS;ETEYEYSGSEEEDDSHGEE;FFASVRSGG;FIGTPYWMAPE;FPASHEPDPAV;HQRQRRIEEQKEERRRVE;KSLQQQQQQQQ;PLSQTPPMQRPVEPQ;RVPLKPYA;SEEEDDSHGE;SEEEDDSHGEEGE;SSEDEDESNGEPSEGS;TESGKGQSPP 14 11.8 1.0034 -1.6854 12.8785 0 9.12712 6.43406 0 0 0 0 5.79273 9.92727 0 13.7957 0 0 14.1483 A0A8C0RF40 A0A8C0RF40_CANLF IQ motif containing E Canis lupus familiaris (Dog) (Canis familiaris) HGSGGAAG;KPASLQPCSGEC;PPCPAFPGQEDSDMSSGETVEG 3 4.9 1.0016 -1.3132 0 0 0 0 0 0 0 0 0 0 9.17839 0 10.4863 0 2.94651 A0A8C0RF46 A0A8C0RF46_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLAK;EVQLVESGGDLAKPG;EVQLVESGGDLAKPGG;EVQLVESGGDLAKPGGSLRL;QLVESGGDLAKPGGSLRLSCVA;VRQAPGKGLQ 11 40 0 27.217 13.6646 13.3807 13.2708 12.8569 11.7491 12.9003 13.2985 13.2726 13.3892 11.73 13.4454 12.3209 12.8369 11.6044 11.4027 A0A8C0RF64 A0A8C0RF64_CANLF Small RNA binding exonuclease protection factor La SSB Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] DEYKNDVKNRSV;KKNEERKQNKVEAKLR 2 7.4 0.93528 0.099673 0 0 0 0 0 0 3.18392 6.43663 0 0 3.06364 0 0 0 0 A0A8C0RF66 A0A8C0RF66_CANLF Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) GARS1 Canis lupus familiaris (Dog) (Canis familiaris) glycyl-tRNA aminoacylation [GO:0006426] cytoplasm [GO:0005737] ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; transferase activity [GO:0016740] ENEMAHYACDCW;RQHMENEMAHYACDCWDA;TLKRRFFYDQ;TWRQHFIQEEQILEIDCTMLTPEPV;YTVFEHTFHV 5 8 1.0017 -1.8046 0 11.1607 13.1173 0 0 0 0 13.0391 0 0 0 12.8242 0 8.87992 11.1076 A0A8C0RF98 A0A8C0RF98_CANLF Potassium channel domain-containing protein KCNK17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] PASPALCGPRARAA;VGIPLNLVVLNRLGHL;VGSFFFSV 3 11.8 0.98511 -0.43118 0 8.08789 0 0 0 10.2673 0 0 0 0 0 0 0 0 8.81477 A0A8C0RFB1 A0A8C0RFB1_CANLF GOLD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793] GAWPARGAGAH;GGGWGVGG;SLSTGRRRWR 3 6.2 0.9969 -0.57597 7.27557 0 0 0 0 0 0 0 5.49659 0 0 0 0 0 0 A0A8C0RFB9 A0A8C0RFB9_CANLF PEHE domain-containing protein KANSL1 Canis lupus familiaris (Dog) (Canis familiaris) H4 histone acetyltransferase complex [GO:1902562]; intracellular membrane-bounded organelle [GO:0043231] DVPTNLHFQSMLKSQWQNKP;MSVAATTRVEKLQY 2 3.4 0.99623 -0.099612 0 0 0 0 0 0 11.3058 0 0 0 0 0 0 0 1.99313 A0A8C0RFC0 A0A8C0RFC0_CANLF Kinesin family member 1B KIF1B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AGLPCQGTFLLHQGI;CNEEMSYSVEVS;DIEEIRPGS;DTSVAYVRGEEN;EMEKRLQEMEILYKKEK;FYDRFHWFKLVGR;KSSHNSSRTFYRFEAVWDSSLH;NSWSPGTHII;SELHWKDVREL;SFDNEYFNQNDF 10 6.6 0.98929 -0.19801 0 0 0 0 0 0 0 6.65406 0 0 0 0 0 0 0 A0A8C0RFD5 A0A8C0RFD5_CANLF "Large ribosomal subunit protein bL35m (39S ribosomal protein L35, mitochondrial)" MRPL35 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LSNVLKLPVRT;RVAPLLSNVLKLPVRTVTYF 2 12 0.94319 0.083697 0 0 0 6.39623 0 0 0 0 5.75948 0 0 0 0 0 0 A0A8C0RFD7 A0A8C0RFD7_CANLF Guanine nucleotide-binding protein subunit gamma GNG7 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] heterotrimeric G-protein complex [GO:0005834] G-protein beta-subunit binding [GO:0031681] EQLRIEAGIERIKVSKASSELMS;GVPASENP 2 45.6 1.0035 -1.058 0 0 0 10.373 0 0 0 0 0 0 0 0 0 0 8.19269 A0A8C0RFE2 A0A8C0RFE2_CANLF Rho GTPase activating protein 9 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] VDLRGAALAHGRHLSS;VRNKLKRLIAKRPPLQ 2 5 0.935 0.098466 0 9.36146 0 0 0 0 0 0 0 0 0 0 0 0 6.74281 A0A8C0RFE6 A0A8C0RFE6_CANLF C2H2-type domain-containing protein BNC2 Canis lupus familiaris (Dog) (Canis familiaris) AQDTHSEEAEVDVRER;DRWAIMSREEE;DSMTSEDQEPERDYEN;EAEVDVRERETQRDRE;ESMEGDEHIHSE;NESESSEPKLGEESMEGDEH;QPSLSKDL;SEVSEKVLMSSER;TADEFDDEDDDP;VPVRLKILL;VQAIRCTLVNCTCECF 11 11.6 1.0035 -2.0864 0 8.96633 0 0 9.90682 7.23764 7.23333 5.84967 10.3219 0 0 8.80035 9.69106 9.35436 0 A0A8C0RFF4 A0A8C0RFF4_CANLF Alanine--tRNA ligase (EC 6.1.1.7) AARS2 AARS Canis lupus familiaris (Dog) (Canis familiaris) alanyl-tRNA aminoacylation [GO:0006419] cytoplasm [GO:0005737] alanine-tRNA ligase activity [GO:0004813]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] AALKVLQRRANTALRKL;CLGPSELFPAEVAWSLSLSGNLGLP;DLVELMLEEK;FLSFFRDRHG;GAPLVLRRILRRAVRFSTEVLQ;NPRSEMAGFRRVANSQKCVRAGGR;PEGLKVGDQVQLHVDEAPL 7 13.4 1.004 -1.086 0 0 0 0 0 10.9511 6.75756 0 0 0 11.3494 0 0 6.77742 11.2857 A0A8C0RFF8 A0A8C0RFF8_CANLF LRAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HYDPHAGIKMS;LLGCLSWAAKGENHYDPHA 2 13.8 0.94777 0.085044 0 9.40716 0 8.42522 0 0 0 0 0 9.72766 0 10.4348 0 0 0 A0A8C0RFH5 A0A8C0RFH5_CANLF 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) PSMD4 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome regulatory particle, base subcomplex [GO:0008540]" polyubiquitin modification-dependent protein binding [GO:0031593] DTSEPAKEEDDYD;FLPTRLQAQQDA;VLESTMVCVDNSEY 3 10.3 0.85294 0.17119 0 0 0 7.64962 0 7.7449 0 7.49506 0 0 0 0 0 0 0 A0A8C0RFL4 A0A8C0RFL4_CANLF Fe2OG dioxygenase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] LFGGLPANHVLVN;LQEGPNPSYLQASGPA;LYEPRQPKDDDPAEQVGP 3 13.9 0.98563 -0.44253 12.1508 0 0 0 0 0 0 11.4831 0 0 0 0 4.38778 0 0 A0A8C0RFM1 A0A8C0RFM1_CANLF Olduvai domain-containing protein PDE4DIP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815] AGGSATSH;DETIITQQSVSDSHL;GLFYSQLE;QKGSVSGD;QLSQEKQQLLHLLEEPMSMEI;VIEGQNDTMAKLREMLHQ;VPGGKGIHEL 7 3.3 0.99856 -3.2736 0 0 13.9936 9.7741 0 4.74147 0 10.1649 8.1531 0 11.0111 8.66927 9.38208 0 0 A0A8C0RFM2 A0A8C0RFM2_CANLF Golgi associated RAB2 interactor protein-like Rab2B-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PEVTLSRILPLK 1 4.2 0.95268 0.05044 0 0 0 0 0 7.63677 0 0 0 0 0 0 0 0 0 A0A8C0RFM4 A0A8C0RFM4_CANLF Lamin B2 LMNB2 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652] structural molecule activity [GO:0005198] EEEVRETRRRHE;EEIAYKFT;GVSIEEIDLE;LMRVDLENRCQSLQ;LSSDQNDKAASAAREE;PLSPTRLSRLQ;QQLAEYQELLDVKLALDME 7 14.2 1.0034 -1.701 0 0 0 9.0617 9.8593 0 0 7.64104 0 0 0 0 0 11.4597 12.3053 A0A8C0RFN3 A0A8C0RFN3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytoskeleton organization [GO:0051493] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAMEKEAKVMAN;EIEAFDSESMRLGFSNMVL;PLACALRGPRARGT;SNMVLSNLSPEA 4 4.1 0.99272 -0.28665 5.44092 0 13.5113 7.12412 0 0 3.88694 0 3.35149 10.8038 0 0 0 0 9.93656 A0A8C0RFN4 A0A8C0RFN4_CANLF PX domain-containing protein SNX20 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091] APLLEAMIRLAYGLG;VLERRYSDFEMLQKNLLKTFREEM;YLSLLYAIRCVR 3 16.9 0.99282 -0.17174 9.82715 0 0 0 0 0 8.30401 0 0 0 6.75995 0 0 0 0 A0A8C0RFP0 A0A8C0RFP0_CANLF Fibrinogen C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; protein polymerization [GO:0051258] fibrinogen complex [GO:0005577] signaling receptor binding [GO:0005102] DDTDEEERI;DDTDEEERIV;DDTDEEERIVS;DDTDEEERIVST;DDTDEEERIVSTV;DDTDEEERIVSTVD;DDTDEEERIVSTVDA;DDTDEEERIVSTVDARGHRPL;DEEERIVS;DEEERIVST;DEEERIVSTV;DEEERIVSTVD;DEEERIVSTVDA;DTDEEERIVS;DTDEEERIVST;DTDEEERIVSTV;DTDEEERIVSTVD;DTDEEERIVSTVDA;EAPSLRPAPPPISGGGY;EEAPSLRPAPPPISGGGY;EEERIVST;EEERIVSTVDA;EERIVSTV;EERIVSTVD;EERIVSTVDA;ERIVSTVDA;ETSEMYLIQPHSSI;GVVWMNWKGSWYSMKKM;HYYDDTDE;HYYDDTDEE;HYYDDTDEEE;HYYDDTDEEER;HYYDDTDEEERIV;HYYDDTDEEERIVS;HYYDDTDEEERIVST;HYYDDTDEEERIVSTV;HYYDDTDEEERIVSTVD;HYYDDTDEEERIVSTVDA;HYYDDTDEEERIVSTVDAR;HYYDDTDEEERIVSTVDARGHRPL;KNLLLLLL;REEAPSLRPAPPPISGGGY;RIVSTVDA;TDEEERIVS;TDEEERIVSTV;TDEEERIVSTVDA;YDDTDEEERIV;YDDTDEEERIVS;YDDTDEEERIVSTVDA;YYDDTDEEER;YYDDTDEEERIV;YYDDTDEEERIVS;YYDDTDEEERIVSTV;YYDDTDEEERIVSTVDA 54 17.8 0 323.31 19.4103 19.5339 19.4857 17.883 18.0827 18.1354 19.8185 19.8031 19.8451 19.3626 19.448 19.4682 19.5612 19.615 19.527 A0A8C0RFP2 A0A8C0RFP2_CANLF SET domain-containing protein SETD5 Canis lupus familiaris (Dog) (Canis familiaris) KELEMEQQNEAPE;LDENTTEGWENRI;MYAYSPLNAMPRADGLY;QAIAQQAELSQ;QNALEQHLHSSKEF;SEEECRNGYSL;TSITLTVRRTKPKKRKKS 7 7.2 0.98764 -0.4685 0 12.4757 0 6.08806 11.1921 0 0 0 3.45444 0 1.66644 10.1339 9.76558 0 0 A0A8C0RFP5 A0A8C0RFP5_CANLF P-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] apical plasma membrane [GO:0016324] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DVVKTNAGF;EQVVQEYLELIGR;GDVVKTNAGF;HTWGMFSR;IIGMMEFSLF;ITPVLDEGAEKVMAYIPD;LQVALITEIDLILGEAY;LSAQDSLESKD;PVNYKGFP;QEPAQNTHLSR;SAQDSLESKD;SAQDSLESKDPG;TTLELMLSVLLLMVF;VLSAQDSLESKD;VLSAQDSLESKDPG;VSISSVSISVSGMV 16 7.5 0.98805 -0.47015 0 0 0 0 0 0 0 0 10.3868 0 0 0 0 0 0 A0A8C0RFQ6 A0A8C0RFQ6_CANLF EGF-like domain-containing protein TMEM8B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] DSGLGSSCLQPYCCCCC;FSTFYHACDQ;GSSCLQPYCCCCC;LDTFSVHFYI;LDTFSVHFYIFFGP;LQPYCCCCCSL;PPWGHWVYV;SSCLQPYCCCC;YCCCCCSLSL 9 7.6 1.003 -2.4172 0 6.41197 8.55528 5.37757 0 0 0 0 5.63828 0 0 9.32396 9.19586 0 8.60259 A0A8C0RFR7 A0A8C0RFR7_CANLF DLEC1 cilia and flagella associated protein DLEC1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285] AGWHLVGG;ELAFHWQIMKPN;IMKPNLQSLMPGETYSLDSLKYHPD;KYHPDRETAF;LLHGPGPD;LSDLALPCTVSG;TGYANMWGEYWDNLICT;VEDFELSFTGGVPGPVSQDLLCEI;YTVDSQTGDLSL 9 7 1.0032 -2.0951 0 11.7476 0 0 0 0 0 10.5217 11.2077 0 9.34877 0 0 9.28364 0 A0A8C0RFT2 A0A8C0RFT2_CANLF Protein CNPPD1 CNPPD1 Canis lupus familiaris (Dog) (Canis familiaris) cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901] MVASKYLYDEGEEE;QAQPRAAPRAGAPAAAAAAA;RLLLRLAARLPHAQAQTQ;TASASRSSLQ;VLSWLESCVAEQQGRRRGWYTYTDL 5 11.1 1.0011 -0.70474 11.1114 9.44524 0 0 0 9.60329 10.1436 10.6453 14.1714 0 0 0 0 0 9.67661 A0A8C0RFX2 A0A8C0RFX2_CANLF EF-hand domain-containing protein CALB2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of long-term synaptic potentiation [GO:1900271]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509] cytosol [GO:0005829]; dendrite [GO:0030425]; nucleus [GO:0005634]; terminal bouton [GO:0043195] calcium ion binding [GO:0005509] ANRPYDEPKLQEYTQTILRMFDLN;DLLKKANRPYDEPKLQEYTQ;SSTEFMEAWRK;TCTCTHTHTHTL 4 16.7 0.86731 0.17722 0 9.69049 10.2664 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RFY5 A0A8C0RFY5_CANLF Sperm associated antigen 8 SPAG8 Canis lupus familiaris (Dog) (Canis familiaris) microtubule binding [GO:0008017] SRHQYLYRWGSLCPMNLRIIPTNWE;SVTHHDYRKE;WRRLGFEPVCVSRFSQDP 3 11.1 0.97382 0.035538 0 0 0 0 0 0 9.68722 0 0 0 0 0 0 0 0 A0A8C0RFY9 A0A8C0RFY9_CANLF Solute carrier family 29 member 1 (Augustine blood group) HSP90AB1 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] nucleoside transmembrane transporter activity [GO:0005337] ASAAMICAIASGSELSESAFG;FSLPNLCALPAACPYKSLK;HECGGPPRGCGGQTRREGP;SLCMCFGP 4 8.6 1.002 -1.291 0 0 0 6.82718 0 0 0 9.48016 0 0 0 8.65982 0 0 0 A0A8C0RG02 A0A8C0RG02_CANLF Transmembrane 4 L six family member 1 TM4SF1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCGCCGHENCG;DDCCGCCGHENCGKRCAVGPPAP;EDDCCGCCGHENCG;EEDDCCGCC;EEDDCCGCCGHE;EEDDCCGCCGHEN;EEDDCCGCCGHENCG;TDGQYLLDTSTWS 8 16.4 0.97862 0.046253 0 0 0 0 0 0 0 0 0 0 5.17465 0 0 0 0 A0A8C0RG14 A0A8C0RG14_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVNPG;EVQLVESGGDLVNPGG;VRQAPGKGLQ 7 17.4 0 3.335 0 0 0 8.61117 0 9.64913 0 0 0 8.71826 0 9.57302 0 9.83078 0 A0A8C0RG16 A0A8C0RG16_CANLF PDZ and LIM domain 1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371] EILESEEKGDPNKPSGF;PTPPRPPPRARRLREGGRA;RAMATQQIVLQGPG 3 10.9 0.99028 0.024766 0 0 0 7.85991 0 0 0 0 0 0 0 8.59373 0 0 0 A0A8C0RG32 A0A8C0RG32_CANLF SEC7 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DEALNCHPSGPMSE;ESELEKQKGMMRP;ESRMSRRIILSNMRMQ;LSPEFGPG;VTTSGEFSN;YGGSCGGG;YRVESELEKQKGMMRP 7 6.8 0.98257 -0.25102 0 0 0 0 0 0 0 0 0 0 0 0 8.85798 0 0 A0A8C0RG36 A0A8C0RG36_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP3 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] chromosome [GO:0005694]; nucleus [GO:0005634] NAD+ ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779] HLRYLLEVHL 1 2 0.99086 -0.27522 0 0 0 0 0 0 10.2688 0 0 0 0 0 0 0 0 A0A8C0RG39 A0A8C0RG39_CANLF ER membrane protein complex subunit 1 Canis lupus familiaris (Dog) (Canis familiaris) EMC complex [GO:0072546] AEKPSPQDSLTCFNQTYTI;ESVRYIAVL;KTTLALHHLSS;LQSLDLEFASGFQP;MFYDARKPRSQI;SIFFYLVDAEQGR;TLALHHLSSG;VEHLPESDSIHYQM;VLWGREESLAE 9 10.7 1.0032 -0.86884 0 0 8.38892 0 0 0 10.245 0 10.5027 10.0135 6.15137 0 0 0 0 A0A8C0RG57 A0A8C0RG57_CANLF Ecm29 proteasome adaptor and scaffold ECPAS Canis lupus familiaris (Dog) (Canis familiaris) proteasome assembly [GO:0043248] cytoplasm [GO:0005737] molecular adaptor activity [GO:0060090] ESLGKAWPRNVETQRCYR;FPEMVYYIQ;LATMETDS;QLPVETLLVQYQDP;SFPEMVYYIQ;SRQAAETFPANIQ;TVVFQGGSLGKTPDGQ;WNALVTDKSTVDKY 8 5 1.0027 -1.7746 0 0 0 9.75382 0 0 0 9.12428 0 0 9.99548 0 8.70318 11.9487 0 A0A8C0RG60 A0A8C0RG60_CANLF Proteasome assembly chaperone 4 Canis lupus familiaris (Dog) (Canis familiaris) proteasome assembly [GO:0043248] PAPPPPPGPAHSP;PGPAHPPPGPAH 2 10.2 0.9904 -0.20212 0 0 0 0 0 0 0 0 11.2728 0 10.4625 0 0 0 0 A0A8C0RG73 A0A8C0RG73_CANLF Aryl hydrocarbon receptor nuclear translocator 2 ARNT2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] GQFQGRPSEVWSQWQSQHH;LTEVPDISSTRITDSP;QGSKYCLVAIGR;RPPFPGQQIPSQ 4 7.5 0.99221 -0.17086 0 0 0 0 0 11.1906 0 0 0 0 0 0 0 0 0 A0A8C0RG94 A0A8C0RG94_CANLF Fibronectin type-III domain-containing protein IL27RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EVVPPAQTPGDF;GVGGPGGP;GVLLLWGLFL 3 4.5 0.98949 -0.26592 0 10.0868 0 0 0 0 0 0 0 0 8.06722 0 0 0 0 A0A8C0RGA3 A0A8C0RGA3_CANLF DUF4537 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CCQLLCQGCLCCCSLA;LLGSGTREPQ;QQRYGPGTVLLGSGTRE;QWVPLAVW;VERLHKPLI 5 12.8 1.0024 -0.77034 0 0 0 0 0 0 6.95548 0 0 0 0 11.0694 10.0137 9.46316 0 A0A8C0RGC1 A0A8C0RGC1_CANLF Family with sequence similarity 234 member A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ACILVGRPSSFVAVDLFTG;ASPGQGSAAASPAHCSPGPDGS;VLLDGQDLTPRWTFRTA 3 7.8 0.9949 -0.12855 0 6.75729 0 0 0 0 10.1678 0 0 0 0 0 11.006 0 0 A0A8C0RGC2 A0A8C0RGC2_CANLF Family with sequence similarity 219 member B Canis lupus familiaris (Dog) (Canis familiaris) AAPRGPAAPSPALGGPPG;PMASSTCSCCWCCPG;SSTCSCCWCC;STCSCCWCCPGDSSSC;TAGGAAGA 5 15.1 1.0036 -1.0561 0 0 0 9.07264 0 7.79116 0 0 0 0 0 0 0 0 0 A0A8C0RGC3 A0A8C0RGC3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PDVFPGEFYQTFKEE 4 5.1 0.95657 0.053877 0 0 0 10.1764 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RGD0 A0A8C0RGD0_CANLF Nucleoside phosphorylase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleoside metabolic process [GO:0009116]; nucleotide catabolic process [GO:0009166] cytoplasm [GO:0005737] uridine phosphorylase activity [GO:0004850] EDVLYHLSLS;HSPTQQITNDLARVLRSF;LGLDHPGA;NRLDGDQVPP;TDESSGLNPSL;TSTTAATG;VLAAMCSACG 7 14.2 1.0013 -2.688 7.20359 0 9.9284 10.7123 11.057 10.8496 0 0 9.53084 9.95507 0 0 9.50078 0 9.59777 A0A8C0RGD2 A0A8C0RGD2_CANLF Family with sequence similarity 234 member A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ACILVGRPSSFVAVDLFTG;PTPGVVHFPRSLGKTL;VLLDGQDLTPRWTFRTA 3 8.8 0.98982 -0.26363 0 0 0 0 0 0 0 12.7259 0 0 0 0 0 0 0 A0A8C0RGD3 A0A8C0RGD3_CANLF Fibrillin 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] CTDIDECEDNPNICDGGQ;DECREIPGVCENGV;DECSIMNGGCETFCTNSEGSY;EECTLPVAGRHRMDACCCSV;GCETFCTNSEGSYECSCQ;GYPPPPLG;IDECQRDP;MMTCEDINEC;NNDCIDVDEC;PVCESGCLNGGR;QNDKCEDTDECSVGN;SCEDVDECEGNHRCQHG;TPGDFECKCDEGYE;TQHHTACIDNNE;VGRAWGHPCEMCPAQPH;VGSFQCQCNEGYE;VILEDIDE;YHCLCKNGYTPDITGTSC;YTSHGADANLEAGNV 19 9.4 0.95547 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 3.91246 0 A0A8C0RGD8 A0A8C0RGD8_CANLF Nose resistant-to-fluoxetine protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" ALHRTLWAAGVGWI;DTFFLISG;IFMHQNHQAN;LKRYLLGPLPAGP;SEASENATVLYFS;SGHTSQMTAWLSLDNVLEW;TDTNMFYLFFGHC;TWYLANDFQFHL 8 14.9 0.95053 0.049546 0 0 0 0 7.67228 0 0 0 0 0 0 0 0 0 0 A0A8C0RGE8 A0A8C0RGE8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) TVWYWHKNRLIDQW 1 1.9 0.98623 -0.23536 0 0 0 0 0 0 0 0 11.303 0 0 0 0 0 0 A0A8C0RGG0 A0A8C0RGG0_CANLF Solute carrier family 22 member 23 SLC22A23 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AASPPAPAPAPWAPP;CGKRSFGCVFTGLHRIE;PGNASRGGADAPPL;TAGDGLPENAT;VGMFASHAV;VGRRPVLL;VGRRPVLLFSIIFILIFGLTVALS;VLPFLGGLGGGYQRT 8 14.8 1.0044 -2.0102 3.64259 0 0 0 11.2355 0 4.94659 0 0 0 0 11.1055 0 0 0 A0A8C0RGH7 A0A8C0RGH7_CANLF Mannose-6-phosphate isomerase (EC 5.3.1.8) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; GDP-mannose biosynthetic process [GO:0009298] mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270] EQGGGPRGLPGRA;PCLASAEEPSCPLCR;TPIPLQRGGV;VRVPRGCGARPRKLTRRPRPP 4 9.7 0.99891 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 9.27188 0 0 A0A8C0RGH9 A0A8C0RGH9_CANLF Bromo domain-containing protein BRD7 Canis lupus familiaris (Dog) (Canis familiaris) EDSGCWPREREDSGDTEAQA;IDRIVKES;NLEREQEQIDRIVKESG 3 5.7 0.9864 -0.41069 0 4.95322 0 0 0 0 8.37456 0 0 0 0 0 0 0 0 A0A8C0RGI2 A0A8C0RGI2_CANLF Ribosome biogenesis protein NOP53 NOP53 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AFQEMCQGLLEESDGEE;CFSNSTWPQDAAGNV;LEVDQFLEDV;RSQKRSLLLKKPLRVD;SCFSNSTWPQDAAGNVLDQ;SQKRSLLLKKPLR;TAAGGAGTAA;VQKRWFLKTVVVKQSGEVARV 8 17.3 1.0024 -0.76933 0 0 13.3122 6.00455 6.30278 0 7.99904 0 0 0 8.87184 8.84947 12.8962 0 0 A0A8C0RGL9 A0A8C0RGL9_CANLF Olduvai domain-containing protein PDE4DIP Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; regulation of Golgi organization [GO:1903358] centrosome [GO:0005813]; Golgi apparatus [GO:0005794] molecular adaptor activity [GO:0060090] DETIITQQSVSDSHL;GLFYSQLE;QKGSVSGD;VCRLLQSLPTRS;VIEGQNDTMAKLREMLHQ;VPGGKGIHEL 6 2.8 0.98787 -0.23427 0 0 0 0 0 0 0 10.1968 0 0 0 0 0 0 0 A0A8C0RGM4 A0A8C0RGM4_CANLF Family with sequence similarity 183 member A Canis lupus familiaris (Dog) (Canis familiaris) ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] QENRFWKEGVRWAAP 1 4.8 0.95269 0.053886 0 0 0 0 0 0 0 0 0 0 0 0 9.38608 0 0 A0A8C0RGQ0 A0A8C0RGQ0_CANLF DNA damage regulated autophagy modulator 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] lysosome [GO:0005764]; membrane [GO:0016020] SLRKKLKHRGRRLLASLR 1 3.4 0.97755 0.048313 0 6.14023 4.19865 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RGR7 A0A8C0RGR7_CANLF ribonuclease III (EC 3.1.26.3) DICER1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic DNA fragmentation [GO:0006309]; pre-miRNA processing [GO:0031054]; siRNA processing [GO:0030422] cytoplasm [GO:0005737]; nucleus [GO:0005634]; RISC complex [GO:0016442] ATP binding [GO:0005524]; deoxyribonuclease I activity [GO:0004530]; helicase activity [GO:0004386]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723] AEYYKTKYN;AKPIPQIPHFPVYTR;DTGETDIEPVVDDDD;DTGKQSISYDLHTEQCI;EDADYEDDFLEYDQ;ELCAIHPIPASLWRK;FSSDFEDFDYSSWDAMC;FSSQQKNLS;ITKHLYEDPRQ;LVPELCAIHPIPA;RLPSDPFTHLA;SDSEDDDEDEE;TTAAMPGTTEAV;VEWYNNRNQDNYVSWSDSEDDDEDE;VGKETVKYEEEL;VSWSDSEDDDEDEEIEE;VVGKGKFK;YVSWSDSEDDDED 18 10.7 1.0025 -2.5813 10.6927 10.7553 4.33364 7.92707 4.0616 0 10.8285 0 5.87843 7.75696 0 6.20412 15.4245 0 13.1638 A0A8C0RGT7 A0A8C0RGT7_CANLF "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86)" INPPL1 Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376]; phosphatidylinositol dephosphorylation [GO:0046856] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020] phosphatase activity [GO:0016791] APNGLSTVSHEY;GVAAPPPKNSFNNPAYYVLEG;LTSASFWTPCSSASDS;LWNIKVAVL;TDDIVTSDHSPVFGTFEVGV;TLSEVDYAPAGPGRSVL 6 7.2 1.0026 -0.84886 8.87885 0 0 8.34243 0 7.15886 0 0 0 0 0 0 11.6792 0 0 A0A8C0RGV0 A0A8C0RGV0_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AGLSMGYFGRRITVVSL 1 3.2 0.98719 0.046227 0 6.64544 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RGV2 A0A8C0RGV2_CANLF Nck-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cell projection assembly [GO:0030031]; cortical actin cytoskeleton organization [GO:0030866]; neuron projection morphogenesis [GO:0048812] lamellipodium membrane [GO:0031258]; SCAR complex [GO:0031209] AAAAGPGTMSRAVLQPSQ;ETDKTTTRNRE;GPGTMSRAVLQPSQ;PSQSRYSIAFP;RGGAGSAG;SAGGGAGRGAGPGVAAAAPGP 6 5.4 1.0021 -1.2929 0 0 0 0 0 9.31723 0 12.6682 13.883 0 0 0 0 0 11.6065 A0A8C0RGX8 A0A8C0RGX8_CANLF Macro domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CRTLQSCETGK;VVLAALREWLEQHK 2 7.7 0.98529 -0.24078 0 0 0 0 0 0 0 0 0 0 5.10823 0 0 0 0 A0A8C0RGZ1 A0A8C0RGZ1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CDRQGDRSVHSEH;EMNMECDRQGDR;LSHSYLGSPD;PIQDSFQKPLD;REPEMNMECDRQGD;VSIAEKLL 6 4.9 0.9894 -0.52071 0 0 0 0 0 0 9.82991 0 0 0 0 0 0 0 0 A0A8C0RGZ9 A0A8C0RGZ9_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] metal ion binding [GO:0046872] EERRLHKKVC;HGAYLGYTVTSVMSSRQG 2 2.5 0.9913 -0.26957 6.53625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RH54 A0A8C0RH54_CANLF Tr-type G domain-containing protein GTPBP2 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] FQVDEIYTVPEVG 1 2.7 0.93955 0.070319 0 0 0 0 0 0 0 12.7891 0 0 0 0 0 0 0 A0A8C0RH64 A0A8C0RH64_CANLF V-SNARE coiled-coil homology domain-containing protein STXBP5L Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] VAFGNCNG;WDASAITLQMLYKLKTSKVFEKQKI 2 2.8 0.98904 -0.21898 0 11.2745 0 0 0 0 6.11541 0 0 0 0 0 0 0 0 A0A8C0RH67 A0A8C0RH67_CANLF "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)" SUCLG2 Canis lupus familiaris (Dog) (Canis familiaris) succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] ATP binding [GO:0005524]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] FVNGAGLAMATCDII;SRETYLAILMDQSCNGPVLVGS;VVRLEGTNVHEARN 3 11.5 0.98541 -0.43664 0 0 9.89662 0 0 0 0 0 0 0 0 0 12.9383 0 0 A0A8C0RH75 A0A8C0RH75_CANLF Glutamate decarboxylase 1 LOC483960 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] ENVLTDLSN;GCERDQELQKIAPKIKAQ 2 5.3 1.0027 -0.7559 0 0 0 0 7.07756 0 0 0 0 0 0 5.43823 0 0 0 A0A8C0RH82 A0A8C0RH82_CANLF Tyrosine-protein kinase (EC 2.7.10.2) CSK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] WALNMKDLKL 1 2.2 0.98428 -0.24183 0 0 0 0 0 0 0 0 0 0 0 0 13.215 0 0 A0A8C0RH86 A0A8C0RH86_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MYO3B Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cell projection [GO:0042995]; cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein serine/threonine kinase activity [GO:0004674] AADVRDAMSKALYGRLFSW;ADHKSSLQ;AFKAHETPFAS;FWMAPEVIA;GFENFGRNSFE;GVKLVDFGV;MSKALYGRLFSWIVNR;SENGHIQK;SLVEAFGN;VGEKNFHIFYYIYAGLY;VLCISPEELQE;VSGTDLLSSWTC 12 9.9 0.98947 -0.26321 0 0 0 0 0 0 0 0 0 0 0 11.6487 0 0 0 A0A8C0RHC3 A0A8C0RHC3_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GLIGLVGLVRAILFILPIPVLLQK;VGLVRAILFILPIPVLLQKMPF;YWMKEHIISNHGQNP 3 12.9 0.87139 0.14189 0 0 0 0 6.74658 0 0 0 0 0 0 0 9.4633 0 0 A0A8C0RHC4 A0A8C0RHC4_CANLF BEN domain containing 3 BEND3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183] heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] rDNA binding [GO:0000182] GAAAASDGD;ILKKAKKV;LKNNTVKV;LYPRAKNDRV;RRDTEQRRSYQQQRKVHVPGPEC 5 7 0.99732 -3.5703 12.1582 0 10.4929 8.27146 0 8.70501 0 0 0 0 8.25729 0 0 0 0 A0A8C0RHD2 A0A8C0RHD2_CANLF CBM21 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GAEGGCCAK;GGPRPASV 2 4.7 1.003 -1.9086 0 0 0 0 0 0 9.35645 0 0 8.86127 8.33454 0 8.75962 0 8.93121 A0A8C0RHD5 A0A8C0RHD5_CANLF Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (Noradrenaline N-methyltransferase) TCAP Canis lupus familiaris (Dog) (Canis familiaris) catecholamine biosynthetic process [GO:0042423]; methylation [GO:0032259] phenylethanolamine N-methyltransferase activity [GO:0004603] REMDGVGRTE 1 3.4 0.44444 0.49912 0 0 0 0 0 0 0 0 0 10.1466 0 0 0 0 0 A0A8C0RHD7 A0A8C0RHD7_CANLF "Proton-coupled zinc antiporter SLC30A9, mitochondrial (Solute carrier family 30 member 9) (Zinc transporter 9)" Canis lupus familiaris (Dog) (Canis familiaris) zinc ion transport [GO:0006829] endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] antiporter activity [GO:0015297]; monoatomic cation transmembrane transporter activity [GO:0008324] FLPPHPSSPPSSPSS;KAPLIKQEPLQVRVKAVLKKR;LRKIRRRSPHE;PEVRHVDL;QMLQEIQEVKTPEELETFMLKHGE;TPSSPLSSQLPPHLPP 6 8.2 0.99825 -0.60774 0 10.2426 0 0 0 0 0 10.8852 0 0 0 0 4.98928 5.02294 0 A0A8C0RHE4 A0A8C0RHE4_CANLF Carbonic anhydrase (EC 4.2.1.1) CA9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] FPAQVESSPRSFEPVHLN;GVQLLLILPLLVPV 2 6.9 0.91794 0.10908 0 0 0 0 0 0 0 0 0 3.43082 0 0 8.63565 0 0 A0A8C0RHE5 A0A8C0RHE5_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) CREB3L2 Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] AGGEAAELNFP;CRMYIDRLQ;GSQRVHYQDHETSFPRALSAQRLSP;KRGTEQENKGRP;LDATSADRFYRIDRSQEHLHFVMEI 5 7.7 0.9833 0.035491 0 0 9.54323 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RHG5 A0A8C0RHG5_CANLF Trichohyalin Canis lupus familiaris (Dog) (Canis familiaris) EEEEEEEESLSEEEEESLSEEVEEV;EEEEEESLSDEEEDEAEME;EEEEPGVKEEELTWD;EEELGEEEEE;ESRLMKVIRSEE;GKKKKAIARKGIGITKRKKK;IGKKKKAIARKGIGITKRKK;IGKKKKAIARKGIGITKRKKK;KKQLKKLLRRIEKNKP;LDKLVLEKRKFKKEARKL;LSDEEEDEAEME;QLKKLLRRIEKNKPEKTQLK;RSQTPEALNWHLLAESQ;SEEEEELGEEEE;SLSEEEEESLSEEVEEV;VEEEEHAG;VHLKVIPP;VLPSATRR;WMETMEMEGQ 19 9.6 0.93587 0.09985 0 5.21711 0 0 0 6.7057 0 0 0 0 0 0 0 0 0 A0A8C0RHG7 A0A8C0RHG7_CANLF Arylsulfatase family member H ARSH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] arylsulfatase activity [GO:0004065] LLLLIPKYARWFVVP;PLLLLIPK 2 2.9 1.0049 -1.0505 0 0 0 0 0 0 5.25871 0 0 4.18126 0 0 0 0 0 A0A8C0RHH2 A0A8C0RHH2_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] AWVRQAASLSDTDNTE;FLHCFEED;SLSDTDNTETTEEQSEERKDEDSVE 3 12 1.0023 -1.0196 0 0 0 7.09371 0 0 0 0 0 0 0 0 7.44733 0 3.46624 A0A8C0RHH7 A0A8C0RHH7_CANLF Phosphatidylinositol glycan anchor biosynthesis class Q Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] membrane [GO:0016020] ALPGNSLSAGGVDPR;RLLVVAVQGLIH 2 4.5 0.95014 0.053897 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85336 A0A8C0RHI2 A0A8C0RHI2_CANLF Fibrinogen alpha chain Canis lupus familiaris (Dog) (Canis familiaris) CSCGGGWDLVGVASRGPG;ELYVCPWEATSC 2 14.7 0.93196 0.098753 4.84077 0 0 0 0 0 0 0 0 0 0 10.2004 0 0 0 A0A8C0RHI5 A0A8C0RHI5_CANLF MYB proto-oncogene like 2 MYBL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PLPWDGADELLELM 1 1.8 0.94427 0.061119 0 0 0 0 0 0 0 0 0 0 0 0 6.21531 0 0 A0A8C0RHJ4 A0A8C0RHJ4_CANLF U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) SNRPC Canis lupus familiaris (Dog) (Canis familiaris) mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; pre-mRNA 5'-splice site binding [GO:0030627]; U1 snRNA binding [GO:0030619]; zinc ion binding [GO:0008270] CDYCDTYL;NTSCFFNMSKFYCDY;NTSCFFNMSKFYCDYCDTY 3 11.8 1.0022 -1.0011 0 0 0 0 0 0 0 8.24027 0 6.28174 0 0 0 0 7.10894 A0A8C0RHL2 A0A8C0RHL2_CANLF Caspase recruitment domain family member 8 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; membrane [GO:0016020] GVSVPITSLTLIYYHFH;NETLLRMVEK;PIILEIAEKRH;VDVSWFQVAHFKDE;VLFKRRILTDLQ;YHFHPEDIKFHLY 6 14.7 0.99048 -0.21307 0 10.5992 0 0 8.58969 7.13196 0 0 6.08006 0 0 7.05582 0 0 0 A0A8C0RHM4 A0A8C0RHM4_CANLF SOCS box domain-containing protein RAB40C Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein localization to plasma membrane [GO:0072659]; protein ubiquitination [GO:0016567] endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EGIDYKTT;SLASGAGG 2 6 0.99116 -0.51184 0 0 0 0 0 0 8.89002 0 0 0 0 0 0 12.0916 0 A0A8C0RHN2 A0A8C0RHN2_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATTSIPEPEGAA;GAGGGGGG;NVEDMDEGSDEVGE;RKSGAGGG;SETYNVEDMDEGSDEVGEEEMVEGN;VGEEEMVEGNDYE 6 5.5 1.0025 -0.89796 0 0 0 6.94169 0 0 8.40386 7.81999 9.74688 0 0 0 0 0 0 A0A8C0RHP1 A0A8C0RHP1_CANLF Signaling threshold regulating transmembrane adaptor 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell homeostasis [GO:0043029] membrane [GO:0016020] ALLAVVSLLLLISLAAH;GGGGGVIC;VEEVPLYGN 3 15.7 1.0032 -1.696 0 9.03075 0 0 0 3.9555 0 0 0 0 0 0 0 0 0 A0A8C0RHP5 A0A8C0RHP5_CANLF Myomesin 1 MYOM1 Canis lupus familiaris (Dog) (Canis familiaris) DPLKKKKDLAAPSP;EIEGAPASPLD;EVSWLKNEKP;INEPTPNDKGKYIM;KRAKKSLLS;MFMEKLQD;QFNWSKDYIP;VPIFSGRQVHVSGLTDTEEE;YFIDKCEVG 9 6.3 1.004 -2.0251 0 0 8.49438 0 0 0 8.90198 0 0 8.64936 9.95466 7.95716 0 4.01837 0 A0A8C0RHQ5 A0A8C0RHQ5_CANLF "Fatty acid-binding protein, adipocyte (Adipocyte-type fatty acid-binding protein) (Fatty acid-binding protein 4)" LOC100686507 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908] cytosol [GO:0005829]; nucleus [GO:0005634] fatty acid binding [GO:0005504] ESTFKNTE;TTIKRKRVDDKL 2 15.5 0.9922 -0.17805 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.58622 A0A8C0RHR5 A0A8C0RHR5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) THSPSVHPSIHPPVHPPF 1 3.8 0.9773 0.048313 0 0 0 0 0 0 0 0 10.9171 0 0 0 0 0 0 A0A8C0RHR6 A0A8C0RHR6_CANLF Mitochondrial ribosomal protein S22 Canis lupus familiaris (Dog) (Canis familiaris) QEAKEQAAEGL 1 6.5 0.97882 0.035491 0 0 0 0 0 0 0 0 0 10.9684 0 0 0 0 0 A0A8C0RHS4 A0A8C0RHS4_CANLF K Homology domain-containing protein FUBP3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] GLPRPVLTP;KDQADFRGV;LVHQRAVITEEFKVPDKM;VLTGTPESIEQAK 4 8.4 1.0021 -1.4756 8.78712 8.80232 0 8.0917 8.91289 0 0 10.5572 0 0 0 0 0 0 0 A0A8C0RHT2 A0A8C0RHT2_CANLF Olfactory receptor OR52H4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVARLACA;ILPVVFLVKRLPFC;KQIRDKIILLFFPKGM;NPIIYGVKTKQ;NPIIYGVKTKQIRDKIIL 5 14.8 1.0027 -1.1596 10.5082 0 0 0 0 0 0 4.60875 0 9.58558 9.66557 9.81327 6.71149 0 8.64623 A0A8C0RHU0 A0A8C0RHU0_CANLF Protein aurora borealis Canis lupus familiaris (Dog) (Canis familiaris) EIAEENTWIKEPVD;ENSHICMSPLAESSV;GCSPIKNWSPMRL;IVPSPWTDHEGKQLSEYHSSK;QALYLSHSRIDK;TWIKEPVDNGSL 6 15.5 0.99608 -0.57106 8.39716 7.98436 0 0 10.3029 11.1119 0 7.12091 0 0 9.56923 0 0 0 12.0935 A0A8C0RHV2 A0A8C0RHV2_CANLF Beta/gamma crystallin 'Greek key' domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] EGEGEGEGAAPGPEDCGDPDDME;GEYPDLSFWDTEEAYI;GSSAPCSRPAGGGPAEAGWRA;REAEGGSAPGAAKQLPSPLES;SATCLLLKGGWGVGNAD 5 4.9 1.0011 -0.74651 9.36124 0 0 0 0 0 9.3971 8.97166 0 11.3222 0 0 5.04072 0 0 A0A8C0RHV3 A0A8C0RHV3_CANLF Phospholipid/glycerol acyltransferase domain-containing protein GPAT3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] O-acyltransferase activity [GO:0008374] RRRWSLEPA 1 1.6 1.0042 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 6.52508 0 0 A0A8C0RHX8 A0A8C0RHX8_CANLF "Lon protease homolog 2, peroxisomal (EC 3.4.21.-) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease)" LONP2 Canis lupus familiaris (Dog) (Canis familiaris) protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] peroxisomal matrix [GO:0005782] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; serine-type endopeptidase activity [GO:0004252] EIIQVPGYTQEE;GTAALAVQVVGSN;KRVIAIRPIRRITHIPGTL;VEQLDRLEEFPNTCKTREEL 4 8 0.79661 0.20967 0 0 9.63702 0 0 0 0 0 0 5.39589 0 9.8805 0 0 0 A0A8C0RHY2 A0A8C0RHY2_CANLF "ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)" Canis lupus familiaris (Dog) (Canis familiaris) "proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" AVVPSPAP 1 1.5 0.98268 -0.25102 0 0 9.21152 8.88441 0 0 9.41975 0 0 9.32993 8.99019 9.45461 8.95948 9.23755 9.30866 A0A8C0RHY5 A0A8C0RHY5_CANLF Neural cell adhesion molecule 1 NCAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] DESKEPIVEVRTEEE;DIQVTVNVPP;FVFRTSAQPTAIPANGS;LAPASSSTPVPLSH;QESLEFILVQADTPSSPSID;SIHLKVFAKPKITYVENQ;VGILIVIFVLLL;VIVCDVVSSLPPTI 8 13.2 0.93913 0.060882 0 0 0 0 0 0 0 0 0 9.17612 0 0 0 0 0 A0A8C0RI09 A0A8C0RI09_CANLF ELK domain-containing protein AKAP9 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090] AEIHCLQERLQ;AINELNIKLQ;DRRSLLSEIQAL;DRTRNWVLQQKIE;DTLASEQKKSREL;ELLEKQMKEKEDDLQ;GVMTITSKD;KALEIDVEE;LNEVIEKLQQELANIEQK;NDKLQWELSVLKSEQNDLR;PESEISTT;QNEMSQKIETMQF;REQENDQPNQEL;SETETLKREHYVA;TEKSTNLLREE;TSLILEKERVEIVE;VEQLTNHLKEKTD;VLLESEKVRIQEMSST;VQSGSTQF;VTEEYNKLLV;VTPESALIKRDEVFSVE 21 6.8 1.0035 -1.6543 10.5261 8.82582 11.3451 11.0128 10.5053 10.0929 10.6432 0 11.2256 0 7.90929 13.0817 0 10.2256 9.93211 A0A8C0RI19 A0A8C0RI19_CANLF Protein phosphatase 1 regulatory subunit 14 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] protein phosphatase inhibitor activity [GO:0004864] PVRGPLRAGRR;RVLSKLQSPSR 2 7.6 0.98994 -0.26623 0 0 10.0286 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RI60 A0A8C0RI60_CANLF Ribosomal L1 domain containing 1 LOC612497 Canis lupus familiaris (Dog) (Canis familiaris) DEAKGICTRIQRKKEAKKKQKQKE;SAPPSPSSSTAASASAPETPA 2 9.3 0.98536 -0.23713 0 0 4.64027 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RI64 A0A8C0RI64_CANLF Ras-GEF domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] TCLGNARMTARD 1 2.5 0.99581 -0.11648 0 0 0 0 0 0 14.3794 0 0 0 0 0 0 0 0 A0A8C0RI65 A0A8C0RI65_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" ASPDFLAQEPVPP;GVAYTDRDRKILQ;LDFLDEEYEV;LVSEDNLQLS 4 5 1.0042 -0.82127 0 0 0 0 0 6.2514 0 10.1981 0 0 0 0 0 0 0 A0A8C0RI68 A0A8C0RI68_CANLF IQ motif containing B1 IQCB1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] calmodulin binding [GO:0005516] AAEVAKSPEQNVPVILLKLKE;EQNVPVILLKLKEI;EVEDQKLHQ;ITLQRSFRSKRTKILLKLNKQ;LPSAVITLQRSFRSKRTKILLKLNK;LSLAAEVAKSPEQNV;PVILLKLKEII;QISTNIEQLMKAP;RSKRTKILLKLNKQKEE;VITLQRSFRSKRTKILLKLNKQKE;YKAAVILQRATLKFLAKCRKRKKL 11 16.9 1.0011 -0.62488 6.11399 9.06194 5.43729 0 8.50398 4.87381 4.49057 10.6309 0 0 0 5.26465 2.82428 6.18128 7.44642 A0A8C0RI83 A0A8C0RI83_CANLF Family with sequence similarity 120B Canis lupus familiaris (Dog) (Canis familiaris) ALCLQGKS;EDTDYLIYDT;GVPMCTDPESRQGVPV;ILGEDTDYLIYDT;LLGDGGDGAGTCPTVKEWFVYS;NQEPGTQARRV;PMCTPPKSNQG;PSDRQLTWTPVQR;RWGRQGSGSH;YGFQNNCLGILGEDTDYL 10 9.4 1.0033 -2.0756 8.72666 0 9.9367 4.07656 0 7.94369 7.81442 0 10.6489 8.85571 0 9.39369 0 0 0 A0A8C0RI89 A0A8C0RI89_CANLF ATP binding cassette subfamily C member 10 ABCC10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GLILALLLVPVNK;GVAAVAWISHCLALWALAHSP;LKANKNNSQEVPAP;LLAYGLGWAV;QDVVLVYRPG;SHCLALWALAHSPH;VGGLILALLLVPVNKVIATRIMA 7 5.4 1.0021 -1.2378 9.93001 0 9.34507 0 0 8.92615 0 0 0 0 10.0881 4.75894 0 13.7582 0 A0A8C0RIC6 A0A8C0RIC6_CANLF Aspartyl aminopeptidase (EC 3.4.11.21) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] CRSRLLQAGFHE;VGFQQVGVETYGGGIWSTW 2 6.6 0.94533 0.05044 0 0 0 0 0 0 0 0 9.72139 0 0 0 0 0 0 A0A8C0RIH4 A0A8C0RIH4_CANLF ENTH domain-containing protein CLINT1 Canis lupus familiaris (Dog) (Canis familiaris) IGMSTAGMGLTGTMGM;PSLNTMIQ;SPKGEFKDEEETVTTKHIHIT 3 7.3 1.0018 -0.68973 0 0 0 0 0 0 0 6.6844 0 0 13.4171 0 0 0 0 A0A8C0RIJ2 A0A8C0RIJ2_CANLF Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase inhibitor activity [GO:0004864] GVGKAAAG;LGKKKKQNKKKQK;SREHRAGS 3 5.9 1.003 -1.3836 0 0 0 0 0 10.0258 4.36135 0 0 0 0 0 0 0 0 A0A8C0RIJ6 A0A8C0RIJ6_CANLF LDL receptor related protein 11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAFCQNLSLDQKT;EQLLEEFRRQLQQERPQ;FFCDDGCC;GGGGGGGG;LLMVACRLRLVKQKLKK;PGGGGGGG 6 13.7 1.0004 -0.92987 0 0 0 0 0 0 0 14.5347 0 0 3.95791 0 8.76474 0 8.18547 A0A8C0RIJ9 A0A8C0RIJ9_CANLF Cleavage and polyadenylation specificity factor subunit 5 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] cytoplasm [GO:0005737]; mRNA cleavage factor complex [GO:0005849] mRNA binding [GO:0003729] LPQLLSRF;QLGTTFFKLPG 2 8.8 0.99524 -0.56457 0 0 9.38396 0 0 8.14873 0 0 4.04002 10.0359 0 0 10.4515 10.4068 0 A0A8C0RIK3 A0A8C0RIK3_CANLF Bromodomain and PHD finger containing 3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AKCRGYPS;DDSKLPPPPTLEPTGP;DFYRFSWEDVDNILIPENRA;EVDIDGRLHRI;EVEYDMDEEDL;GCGEEEEKEEVEEEEEDEGQG;GSGTSFHLPQPSFRM;KIEPMRET;LDMVNEKRRVDGHSVVSADTFEL;SYRLNKICSGLSF;VEYDMDEED 11 11.6 1.003 -0.8716 8.9631 7.25001 11.0373 6.40374 0 0 0 4.49365 0 7.5763 0 0 0 0 0 A0A8C0RIL4 A0A8C0RIL4_CANLF BED-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] AKKKRKKGLRIK;AKKKRKKGLRIKGKR;IKGKRRRKKLIL;KGLRIKGKRRRKKLILAKKF;KKGLRIKGKRRRKKL;KKGLRIKGKRRRKKLI;KKKRKKGLRIKGKRRRKKL;KLPAKKKRKKGLRIK;LKNVNYDYSTLVLSWDP;LRIKGKRRRKKLILAKKFS;MFPSAIAVVD;NFFYTDPQHI;RKKGLRIKGKRRRKKL;RKKGLRIKGKRRRKKLIL;RKKLILAK;VLSWDPGNEVIQSNE;YMSTDPLDENRMGKKRDKSVSDA 17 10.4 1.0021 -1.2829 4.18793 0 9.215 6.9507 12.4873 6.29031 5.27124 3.02882 9.32402 0 0 7.47897 9.93787 5.32326 6.4194 A0A8C0RIL6 A0A8C0RIL6_CANLF HtrA serine peptidase 4 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] HVITNQQRIQVE 1 2.7 0.98225 -0.2498 0 0 0 0 0 0 0 10.6869 10.3698 0 0 0 0 0 0 A0A8C0RIL9 A0A8C0RIL9_CANLF Monocyte to macrophage differentiation associated MMD Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872]; pore-forming activity [GO:0140911] HYYAIWKYLYRS;LFVATAAAVHYYAIWKY;VGSALLHRLSDDCWEKITAWIYG;YRFMNHRAPANGRYK 4 24.3 0.83772 0.19705 8.33989 0 0 0 0 7.78771 0 6.8535 9.78516 0 0 0 0 0 0 A0A8C0RIM6 A0A8C0RIM6_CANLF Mannose receptor C-type 1 MRC1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] AGVVVMVVLLIITGAGLAAYF;ALGGDLASINNKE;AYLTTIEDRYEQAFL;CKEGWHFYNNKC;DDENCVTMYSNSG;ERYFWTGLSDVQNKGTFQWTIE;IEEKVLFTHWNSDM;KLFGYCPLKFEGSESLWNKDPLTG;NWNTGDPSGERNDCV;RSDEIPATEPP;SEFQKWECKNDTLLGIKGEDLFFN;VGNIEQNEHAGI 12 13.3 0.98716 -0.36356 0 0 0 9.68062 0 0 10.3662 13.0928 11.9683 7.24222 0 7.77979 0 9.13635 0 A0A8C0RIN4 A0A8C0RIN4_CANLF "Membrane associated guanylate kinase, WW and PDZ domain containing 1" MAGI1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGIVHAENEEEDDVPE;GGGGQRVK;GVHTEELDSELELPAGWEKIEDP;QLEQQQQPQQQQQQQQQQQQPP;RRERSLEKRDRDRDRDRDRDRDREE;TITTTHTPSQQGTQET;VQPYDVEIRRGENEG 7 8.9 0.97758 0.035538 0 0 0 0 0 0 0 0 0 7.51475 0 0 0 0 0 A0A8C0RIP8 A0A8C0RIP8_CANLF Death domain-associated protein 6 (Daxx) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] "chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; PML body [GO:0016605]" histone binding [GO:0042393] DLEQMQEGQGDDEEEEEEEE;EEEEEEATDSEEEEDLEQ;HSLGLPRQQLQLMAQDAFRDV;SSLTGRVIEQ;TDDEEDEESEEEEEEEEEEEEE;TTSKPETDDEEDEESEEEEEEEEE 6 13.1 0.97195 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 7.85156 0 0 A0A8C0RIQ3 A0A8C0RIQ3_CANLF TNFR-Cys domain-containing protein TNFRSF11A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GNEIQYCTFHFI;MFSEDMCCPDSGG;PDSGGGCG;PDSGGGCGG;PQCAYGMGLPPEG;PSARPASAPCTRLNKDTVCKPCLL;SEDMCCPDSGGGCGGACAGG 7 10.9 1.0032 -2.2849 9.39111 0 0 5.09795 6.40339 0 0 5.16603 0 0 0 4.00117 5.86824 12.6479 0 A0A8C0RIQ5 A0A8C0RIQ5_CANLF DUF4209 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGSIKLLSPVLYLILLLIAL;RQRQTYLH;WEAALIRFRSHSTALYTTFD 3 9.3 0.98644 -0.45607 0 0 10.9701 0 0 0 10.9788 0 11.5708 10.4932 0 0 0 0 0 A0A8C0RIS8 A0A8C0RIS8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] EEEDNEEEDDAGGEDAA;QDEQAEEEEEDNEEEDDA;SRKEYCEL;YIVVKVSLLVVVEIGVFPLIC 4 4.5 1.0013 -0.70781 0 0 0 5.85771 0 0 5.56197 0 0 0 0 0 0 0 0 A0A8C0RIT3 A0A8C0RIT3_CANLF Ankyrin repeat domain 35 Canis lupus familiaris (Dog) (Canis familiaris) AEPEEEQEEEEEEDPCSDEWRWKY;APGGQSSSLRPGGDG;DELALEKEAT;EPEEEQEEEEEEDPCSDEW;LEKEVAALRLSNTNL;TIGKATGQ;TVAEPLGTIAMN 7 9.3 1.0033 -1.5781 10.3021 0 0 5.43736 5.98809 0 0 0 0 5.07758 0 8.05783 10.2183 9.20967 0 A0A8C0RIU1 A0A8C0RIU1_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231] GAGGGGGG;GGGGGGGA;GGGGGGGG;GGRGGGGG;GRVGAEERQVSHP;LTEKNFEDTIAEGLTFIKFYAPWCG;PEPAAEPPRAPERKQ;PSPPPPSPGSRGAAGGRGLG;TPALSSSSRKSPGLLG 9 12.1 0.99306 -0.2839 0 0 8.29646 0 0 10.1176 11.542 0 0 0 0 0 0 0 10.9481 A0A8C0RIU4 A0A8C0RIU4_CANLF ATP binding cassette subfamily C member 5 ABCC5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DDPLSALDAHVGNHI;EPWHLHSEKM;HPKGKYHHSL;IVSRVLIRELKRLDN;LNYRTGVRLRGAIL;RVLIRELKRLDNITQ 6 4.6 1.0018 -1.4133 0 0 0 0 4.43563 0 11.0395 0 0 0 0 0 0 0 0 A0A8C0RIV4 A0A8C0RIV4_CANLF Tudor domain-containing protein 3 TDRD3 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] cytoplasm [GO:0005737]; nucleus [GO:0005634] FYNSGPKRRSG;GSGLPRNRGSERPSTSS;GVPNGETD;RNVAAPKDNEE;RTIGKKFLPS;TNLPGPGTNMRRCLLQIVLLTEEMC 6 10.2 1.0032 -1.5631 7.15218 0 3.63946 0 0 0 0 10.7266 10.7938 0 0 9.98897 0 0 9.41449 A0A8C0RIW0 A0A8C0RIW0_CANLF Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) ADRA2B Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229] plasma membrane [GO:0005886] alpha2-adrenergic receptor activity [GO:0004938] AICPQHCKVPHGLFQFFF;ESKQPHSVPTAASTKLPTLAS;RALEYNSKRTPRRIK;VGTTSGQWWRRRAQLTREKRFTF;WFPFFFSYSLGAICPQHCKVPH 5 19.8 0.994 -0.12052 0 0 7.96185 6.68734 0 0 0 0 0 0 0 5.23209 8.31701 5.91385 0 A0A8C0RIW4 A0A8C0RIW4_CANLF DAGKc domain-containing protein SPHK2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] kinase activity [GO:0016301] LEPPGISGPLGCLVI;SPLHRSVSDLPL 2 3.7 0.99531 -0.15353 0 0 12.1054 0 0 0 0 0 0 0 0 0 0 0 12.1549 A0A8C0RIX0 A0A8C0RIX0_CANLF Sprouty related EVH1 domain containing 3 SPRED3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] membrane [GO:0016020] AEEAARCVH;GGGGGGGG;PQRRRSSAQSYPP;RADGRGGRCAEAPDPGRLL 4 10.8 1.0019 -0.68494 0 0 0 5.94507 0 0 7.34412 0 0 0 0 0 0 0 5.42311 A0A8C0RIX1 A0A8C0RIX1_CANLF Protein kinase domain-containing protein RSKR Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ESMLFKDFDCNLESYLN;FAVKVVPKVKVLQ;TQPTPSESMLFKDFDC;VKVVPKVK;VLCYLHDLGIIHRD 5 12.4 1.0031 -0.88827 5.86498 0 0 9.81099 8.91955 12.9794 0 0 0 0 0 0 6.32366 0 0 A0A8C0RIX8 A0A8C0RIX8_CANLF Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] AEDLEDSLASS;DINRALKEN;GVSILAEDLEDSL;GYVSQLKSLDRSCDQERY;HYFAKKKTLLGLSKLAALAS;QHGIVLKVVYPQ;SEKQAHSWD;VLTAHSSSVCISVKKTEEL 8 8.2 0.98929 -0.22261 0 0 0 0 0 0 9.95313 0 0 0 0 0 0 0 0 A0A8C0RIY3 A0A8C0RIY3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LSGPWWPGSLGSGL 1 7.8 0.99233 -0.037737 12.9361 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RIZ3 A0A8C0RIZ3_CANLF Cytokine receptor like factor 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLNFQWHQEAITVTCSD;EVIHQQKGELRD;FVSFYPEGVLQ;TVSLLLLSLWKVRRVKKL;TVSLLLLSLWKVRRVKKLLMPS;WNGTRLLLNKCQWISAYL 6 20.2 0.98633 -0.41146 0 10.0855 0 0 0 0 0 6.57372 0 0 0 0 9.80363 0 0 A0A8C0RJ13 A0A8C0RJ13_CANLF NHS like 2 NHSL2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] DAQGHPAVPTV;DKTAEWIAEDD;DSGTTDVD;EDTKCPPTSDPLKAPG;KQAAWNSPFPLP;LPKDIYTVMRK;LSRQPSHGHS;PLQAEGEREAS;TSPMEKISKSRLSF 9 10 1.0027 -0.79813 8.17832 0 10.9061 2.99834 0 9.60785 11.2344 9.793 8.77584 9.30305 0 0 9.9201 0 9.82007 A0A8C0RJ15 A0A8C0RJ15_CANLF Non-specific serine/threonine protein kinase Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine/threonine kinase activity [GO:0004674] GPTEAPEFPGEAVSEDEYK;KILVQVPPRFVKKVR;REGQYVEVLDSAHPLRW;VLSPAGVS 4 4.4 0.50602 0.48051 0 10.1267 0 0 7.89954 7.8448 0 5.78832 0 3.96717 0 0 0 0 0 A0A8C0RJ29 A0A8C0RJ29_CANLF Zinc finger protein 621 ZNF621 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLYREVMLEN;GPLFMLLPA 2 4.1 0.98351 -0.25653 6.19895 6.59014 0 0 0 0 0 0 7.39481 0 0 0 0 0 0 A0A8C0RJ59 A0A8C0RJ59_CANLF "MAS1 proto-onco, G protein-coupled receptor" MAS1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] angiotensin receptor activity [GO:0001595] ILSFLVFTPL 1 3.1 0.99921 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 6.75556 0 A0A8C0RJ65 A0A8C0RJ65_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] LFNQHPDVFY;QLRRLLRFSGLRA 2 5.3 0.94001 0.059723 0 0 0 0 0 0 0 0 0 0 0 0 0 8.15573 0 A0A8C0RJ71 A0A8C0RJ71_CANLF SR-related CTD associated factor 4 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]" nucleus [GO:0005634] RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] AGERERERPA;AVEESKKEDAAATATATP;HLQRFPLM;IPKPLPVPVP;IPPPGFGP;QPAYTQHQNMDQFQPR;VIPPTPPVQ 7 5.7 0.99921 -0.61146 0 9.42007 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RJ80 A0A8C0RJ80_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK26 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] LVQTLSCLSMI 1 3.2 0.98705 -0.23498 0 0 0 0 9.91255 0 0 0 0 0 0 0 0 0 0 A0A8C0RJ81 A0A8C0RJ81_CANLF Kinesin-like protein KIF2B Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule-based movement [GO:0007018] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] LSTPLVEDTGRTSWKE;NSCRTSGQT;RDGFINIPNIQSEK 3 5.7 0.9841 -0.25681 0 9.78676 0 0 0 0 0 11.977 0 0 0 0 0 0 0 A0A8C0RJA2 A0A8C0RJA2_CANLF Stomatin STOM Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GEGPLGGS;GVLGGGSRGEGPWG;LSDREEIAH;PVRPPSSR;RILTKDSVTISVDGVVYYRV;VLGTKNLSQILSDREEIAHN 6 12.8 1.0031 -1.9163 0 0 0 0 0 0 11.4778 4.95061 12.7205 9.48325 0 0 0 8.716 0 A0A8C0RJC3 A0A8C0RJC3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) LEVLASATRQQKDIKGIQIGKE;WNRIENPEVDPQLYGQL 2 5.7 0.96458 0.048692 0 7.98316 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RJG0 A0A8C0RJG0_CANLF Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] hydrolase activity [GO:0016787] HYHRNAGGTYQ;IVHFHWFFTLLE;KEIANKLAGAGVTAVFSGHYHRNA;YSLDELSEKGI 4 15.2 0.99697 -0.11247 0 0 0 0 9.71886 7.05409 0 9.1146 0 0 0 0 0 0 9.6705 A0A8C0RJG8 A0A8C0RJG8_CANLF "Zinc transporter SLC39A7 (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7)" SLC39A7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular zinc ion homeostasis [GO:0006882] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]; zinc ion transmembrane transporter activity [GO:0005385]" AFLVVEKFVRHVKGGHGHSHGH;GMIPMGHLGD;VPHEVGDFAILV;VPQKVLDKVIGM 4 10 1.0012 -0.64363 0 0 0 0 0 4.26356 10.0937 0 0 0 9.74529 0 0 0 0 A0A8C0RJH5 A0A8C0RJH5_CANLF Ig-like domain-containing protein IGSF1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] EETEIIMPTPKPELWAETNFP;EPSEPMELVIKEMY;GDDSGVYS;LQDLVFMLFKEG;LVALLLVVLWIRWKCRR;LVALLLVVLWIRWKCRRLRIREAWL;QLVALLLVVLWIRWKCRRL;QQLHAVGREA;SEGVYICRTHIQMLPT;VDGVGLAL;VGTDILPKPVI;YWKETGWSEPSKVL 12 11.3 1.0031 -2.3519 10.8288 8.35865 10 0 0 0 0 0 7.9751 7.6939 8.5324 0 7.66427 10.4278 9.89329 A0A8C0RJI4 A0A8C0RJI4_CANLF HTH merR-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677] EKRRHVNREI;HVNREIKVM 2 12.1 1.002 -1.4157 0 0 0 0 0 0 9.11676 0 0 0 0 0 10.7909 0 0 A0A8C0RJI7 A0A8C0RJI7_CANLF Zinc finger BED-type containing 8 Canis lupus familiaris (Dog) (Canis familiaris) EIGIEYSV;FEEIGIEYSVLLFHTE;FNRQHGGI;GVQLAETMDMGDCS;HRLFQAFFEEIGIEYSVLLFHTE 5 8.3 1.0023 -1.4582 9.102 0 0 0 0 0 0 8.77485 6.99786 0 0 0 0 8.45779 0 A0A8C0RJJ2 A0A8C0RJJ2_CANLF Mesothelin Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] cell surface [GO:0009986]; membrane [GO:0016020] EDLRALSQQN;GARTEDLRALSQQNVS;WTSTRGSLLLLLLSLGWVLP 3 9.3 0.99125 -0.51344 0 0 0 0 0 5.67835 8.75061 0 0 0 0 0 0 0 8.23472 A0A8C0RJJ4 A0A8C0RJJ4_CANLF Chromosome transmission fidelity factor 8 CHTF8 Canis lupus familiaris (Dog) (Canis familiaris) EARYSTGLAGN 1 19 0.98726 -0.2312 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.24921 A0A8C0RJK0 A0A8C0RJK0_CANLF Leucine rich pentatricopeptide repeat containing LRPPRC Canis lupus familiaris (Dog) (Canis familiaris) EENMEKALQLKAKYESDM;GIRNLLDSYHVPEL;HYFWPLLAGHQKEKNVQECLEG;ITELLYKDGR;SFLESNTLPIS;TSAMKSCVLDKD;YKFSPTDFLAKM;YLFRKIIEEQME 8 8.1 0.9878 -0.49651 0 8.39998 7.36159 0 0 0 0 9.99944 8.7878 0 0 0 12.8079 0 0 A0A8C0RJK3 A0A8C0RJK3_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] DPVRPEVP;EVSEQHNHPE;HWTRTARQHPGHHLC;LVMSAITVII;MSTVIRMPD;PHAGGFGC 6 5.8 1.0026 -2.5784 0 0 0 8.9119 0 0 0 0 0 0 0 10.4219 0 0 0 A0A8C0RJL4 A0A8C0RJL4_CANLF RING-type domain-containing protein NFXL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] CSKSRPLGCPHP;EDPPLDPWLVPHSCGQ;PSRYYCYCGKVEDPPLD 3 4.7 0.95105 0.058169 0 0 0 0 0 0 0 0 10.6843 0 0 0 0 10.8969 10.322 A0A8C0RJL8 A0A8C0RJL8_CANLF FCS-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] CSRSYSSN;KASILARLQVTGKPPTKKA 2 4.1 0.98514 -0.25339 0 0 0 0 0 0 0 9.76017 0 0 0 0 0 0 0 A0A8C0RJM6 A0A8C0RJM6_CANLF Protein phosphatase inhibitor 2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] ELEEDTEDEHDQQDSESWAG;GVGGVEADAGPP 2 7.9 0.93303 0.098646 0 8.84859 0 0 0 0 0 0 0 0 0 0 0 0 4.15559 A0A8C0RJM8 A0A8C0RJM8_CANLF pre-rRNA processing protein FTSJ3 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) FTSJ3 Canis lupus familiaris (Dog) (Canis familiaris) "nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" rRNA methyltransferase activity [GO:0008649] EISQAQLLYES;ELKRKKKKLLREQRK;GLKSDDDGFEIVPIE;YTFNEEEGE 4 6 0.98759 -0.48131 0 0 0 7.4287 0 0 10.5975 8.90069 0 0 0 0 0 0 0 A0A8C0RJN1 A0A8C0RJN1_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] DPVRPEVP;KPKCDHHSPPDELVLCV;LVMSAITVII;MSTVIRMPD;PHAGGFGC 5 4.8 0.98695 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.24584 A0A8C0RJN7 A0A8C0RJN7_CANLF Uncharacterized protein LOC111093559 Canis lupus familiaris (Dog) (Canis familiaris) GGLGCGYG;PYCYGRFWPSGF 2 45.5 1.0029 -1.3394 8.94612 0 0 0 0 0 0 0 9.29414 0 0 0 0 0 0 A0A8C0RJQ8 A0A8C0RJQ8_CANLF Transport and golgi organization 6 homolog TANGO6 Canis lupus familiaris (Dog) (Canis familiaris) GDLLSHCQEC;HVIVLLLRGL;SERLMRPSGVQ;SPACGGHQ;VLGSTLYS 5 4 1.0028 -2.5343 0 0 0 0 11.2933 0 0 0 10.522 0 0 0 10.1977 0 8.84496 A0A8C0RJR2 A0A8C0RJR2_CANLF Glycoprotein hormones alpha chain CGA Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179] AALSVFLH;DGEFTMQGCPECK 2 20.2 1.0043 -1.0447 0 0 0 0 0 0 0 5.78751 0 0 0 0 0 0 6.71026 A0A8C0RJT0 A0A8C0RJT0_CANLF ABC transporter domain-containing protein ABCG5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LFVIFYLLRV;VGSGLVRNTEEMSI 2 3.8 0.99089 -0.21337 0 0 7.08979 0 0 0 0 0 0 0 0 0 0 0 8.52924 A0A8C0RJU3 A0A8C0RJU3_CANLF DNA methyltransferase 1 associated protein 1 DMAP1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122] NuA4 histone acetyltransferase complex [GO:0035267]; Swr1 complex [GO:0000812] transcription corepressor activity [GO:0003714] KSSETLTFKRP;LVHMFNELRS;QEYQLYLHDD;TDWLSGRASAPVCTGPAA 4 10 1.0038 -1.0602 0 0 0 0 0 0 0 10.9908 0 0 9.33342 0 0 10.4649 5.71163 A0A8C0RJW5 A0A8C0RJW5_CANLF phenylalanine--tRNA ligase (EC 6.1.1.20) FARSB Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] phenylalanine-tRNA ligase complex [GO:0009328] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] FPELAYRKE;SEKEIISKEQGN;VLRNIKFTKDR 3 6 1.0025 -0.71828 0 0 0 0 0 5.20026 0 7.98988 8.14934 0 0 0 0 0 0 A0A8C0RJX1 A0A8C0RJX1_CANLF SAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] EAFLDGTLPSTNEI;KTPPSILQSRNAPLPSL;LPVDSSVKEAI;PVRKPGPLP;QAEQQSIVPQFYVSS;SLELDAAEKDRK;TDQPPTRS;VGKEDYPQTQ 8 8.9 1.0031 -2.4563 0 11.0273 0 0 9.32191 0 0 10.8823 8.93192 0 0 0 0 0 0 A0A8C0RJX2 A0A8C0RJX2_CANLF RING-type domain-containing protein TRIM69 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] FLQISDAVCFFME;GQLEATLKEL;KIKKLPLLKGHPQ;LREEGKALNEEMELNLNQLQEQC;NLVLEKLVEKIKKLPL 5 20.1 0.99602 -0.091974 0 9.19343 0 0 0 0 0 8.24041 0 0 0 0 4.30122 0 9.58487 A0A8C0RJY4 A0A8C0RJY4_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) binding [GO:0008143] DLEDASFPLSL;HRVTILCDKFSGH;LGAEQASTQVRWPR 3 12.1 0.42763 0.52821 0 0 0 0 10.2959 0 12.3104 12.193 12.5776 12.7616 12.8695 0 11.9785 0 12.1587 A0A8C0RJZ0 A0A8C0RJZ0_CANLF X-prolyl aminopeptidase 2 XPNPEP2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] GSDIPYNPFFYSYTLL;KYPGSYLTFEV;LDKFRGEEDFSSGP;LFNLRGSDIPYNPFFYSY;SGLNAALAHYSPTKEQ;SSCSGSMC 6 11.4 1.0021 -1.2404 5.64953 0 0 0 0 0 7.07682 10.5322 10.1737 0 0 8.6423 10.2257 0 0 A0A8C0RJZ6 A0A8C0RJZ6_CANLF Cortactin-binding protein-2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) APGGGGGSGAALPPPAR;KKPVCTNPLSI;LRDELERLRRALEQLRRPGL;PTRRAPAPPSPRGPT;QARDQAKGPG;VLMLVKECK 6 8.7 1.0044 -1.0964 0 0 0 0 0 0 0 10.0032 0 0 0 0 10.809 0 10.9481 A0A8C0RK12 A0A8C0RK12_CANLF AP-3 complex subunit beta AP3B1 Canis lupus familiaris (Dog) (Canis familiaris) anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665] AAHYFFPRQP;AAPQNFTPSVI;EQQDLALLSISTFQ;ESLEPEGSITVSMGI;GEATELGQEATSTVSPS;VLPTPALSP;VVIKKLLQ;YDQNYDIRDRTRFIRQLIVPNEKS;YSDSEEEEDSSDSS;YSDSEEEEDSSDSSSDSESE 10 11.1 0.99971 -2.8486 8.09371 10.9297 12.0377 4.17377 9.69625 0 0 11.1802 11.0577 2.88973 4.73536 0 0 0 5.96834 A0A8C0RK29 A0A8C0RK29_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGTL;EVQLVESGGDLVKPGGTLR;EVQLVESGGDLVKPGGTLRL;EVQLVESGGDLVKPGGTLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;SRPQCESM;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQSPGKGLQ 25 29.3 0 8.4787 9.52615 0 9.33724 9.82501 8.97654 9.53617 10.439 11.9795 0 7.6034 0 7.83662 0 10.0272 0 A0A8C0RK53 A0A8C0RK53_CANLF Kinetochore protein NDC80 NDC80 Canis lupus familiaris (Dog) (Canis familiaris) attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301] Ndc80 complex [GO:0031262]; nucleus [GO:0005634] ALVWLIDCI;FIQQCIRQLCEF 2 3.5 0.98617 -0.41251 0 10.2551 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RK57 A0A8C0RK57_CANLF Solute carrier family 39 member 5 SLC39A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion transmembrane transporter activity [GO:0046873] FSDGFSSGL;GVGLSLGPVPL;LDHSLADHLNED;RGGAKGRLGQG;VLLLSLPAPLSLLLLR;VLLLSLPAPLSLLLLRLLGARLLR 6 11.9 1.0033 -1.4941 0 0 5.83643 0 5.00032 0 10.7419 0 0 0 5.0461 0 10.3091 0 0 A0A8C0RK76 A0A8C0RK76_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AKSLTYPGETTSALV;APLAPPRHPHR;EALPTIQGYFRQYRQEP;EEAYVIYDEDYEFETSR;GFPIKGPG;GQGLGAGAAAPEGQPSPAVSASQP;LDVPEDINVRVM;LKPRHVKLL;LVENLIPDTMYE;PATVVNDHVSS;TTPLNPPPPLPLKK;VEGSISSF;VEGSISSFPGE;WYECGVSIPGKW;YEFETSRPPTT;YSASYEDFIRNKWSTQAS 16 10.4 0.9325 0.060787 0 7.04067 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RK86 A0A8C0RK86_CANLF Unc-13 homolog B UNC13B Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887] presynapse [GO:0098793] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543] CPMEEMTPSSLEGP;DFLELQTTNSLET;DLDYPERRALRYPQKY;DLDYPERRALRYPQKYTIDRRRKNK;DQCHEQDDDRRERDSIHSCHSS;HFSEADKALESSQMSEAS;IVDEFAMRY;LDPDPTCIAEELPSPVQP;LPLVSDLSLVQ;NLDFWPKLITL;NQSFEIIRKLECPDP;NTLGDQSGCPMEEMT;NVSSIQTTENMPVSSLVNKDEVKSS;QEKALEVTGE;SDLSLVQSRKAGI;SLLPDQPKNCAKN;STGQYAYLFMP;STVDLLTSITFF;TLPSFFST;TNVSSIQTTENMPV;TVTELLHQPETQEEEVMPP;VINNDLGEFGNIDK;VLHCAPSA;VLSHSEKQQDLR;VPAVMSTLLA 25 7.4 0.99756 -3.7573 8.05566 6.47122 13.243 13.6899 9.98968 0 8.17762 13.7815 11.4033 0 8.03925 9.07197 11.4746 11.0053 7.22265 A0A8C0RK95 A0A8C0RK95_CANLF Lipase maturation factor LMF1 Canis lupus familiaris (Dog) (Canis familiaris) protein maturation [GO:0051604] endoplasmic reticulum membrane [GO:0005789] LMATLWVLYMSLVNVGQIWYSFGWE;SPCRCPHVRRAPPSSL;TSPPSASG 3 7.3 0.98756 -0.46172 0 0 0 0 6.64383 0 0 9.56702 0 0 0 10.7589 0 0 0 A0A8C0RKA7 A0A8C0RKA7_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GNNNVTEF;PIDKSVTLVYTVITPM;TTVVVLFFVPCI 3 12.5 0.99347 -0.075111 8.53617 8.86044 0 0 9.62346 0 0 0 12.2909 0 8.34176 8.36785 0 7.02691 0 A0A8C0RKA8 A0A8C0RKA8_CANLF Spermatogenesis-associated protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EGGGGGGRGRGRGEGGV;EQIKKVEKLF;GFIRVSPHL;KTHTGNSEIP 4 8.3 1.0029 -1.3776 10.448 0 0 0 0 0 0 0 10.614 0 0 11.1558 0 9.34848 0 A0A8C0RKC1 A0A8C0RKC1_CANLF Methyl-CpG binding domain protein 5 Canis lupus familiaris (Dog) (Canis familiaris) chromocenter [GO:0010369]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] DRQMRPPKPK;GVLNSASANTAN;IVTTAAGNPLQSQLPIGSDFP;KAVQVVPGLTDQCCPWTTAAGR;LSQSGMALGNSLHPNP;LSSNSTPGCGGSNTALPC;NPLQSQLPIGSDFP;PAIQVPVG;PLSPPSVMLHGSPVQSSC;VGWQRRVDQ 10 8 0.97367 0.046862 4.36261 0 0 8.87593 0 0 0 0 0 0 4.15137 0 0 0 0 A0A8C0RKE6 A0A8C0RKE6_CANLF Peptide deformylase (EC 3.5.1.88) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] metal ion binding [GO:0046872]; peptide deformylase activity [GO:0042586] APPWAWGAAR;QGCLFIDKMDSKTFTNIHWM 2 12.4 0.99464 -0.5628 0 0 0 0 0 7.46671 0 0 0 0 0 8.32418 0 0 0 A0A8C0RKG6 A0A8C0RKG6_CANLF 60S ribosomal protein L7a Canis lupus familiaris (Dog) (Canis familiaris) cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723] IPKGKKAKRKKVAP 1 11.2 0.93558 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 3.51627 0 A0A8C0RKH7 A0A8C0RKH7_CANLF General vesicular transport factor p115 USO1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle fusion with Golgi apparatus [GO:0048280] Golgi membrane [GO:0000139] DDEEDEDEDD;DEEEEVDDVEEENST;ESGDQDDEEDEDE;FTEIFIKQQEN 4 4.2 0.95351 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.99707 A0A8C0RKK9 A0A8C0RKK9_CANLF Potassium channel voltage dependent KCNQ C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated potassium channel activity [GO:0005249] AKDPEPAP;GACPPCGDCG;GDCGGCGG;LDFLVNIYMQRMGIPPTETEA;PCGDCGGCG;PPCGDCGG;VGRGPALT 7 9.3 0.99686 -4.3524 10.3485 9.90751 0 0 7.00101 6.72288 9.89448 9.75144 15.8621 0 0 0 0 4.06523 0 A0A8C0RKL9 A0A8C0RKL9_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] GGGILNKILKKKKNLRRRL;ILNKILKKKKNLRRRLLRWE;ISNGGGILNKILKKKKNLRRRLLR;LNKILKKKKNLRRRL;RLPLQDVYKIG;SNGGGILNKILKKKKNL 6 7.8 0.988 -0.34623 10.8862 0 5.25912 0 5.82459 0 0 9.0337 0 9.89083 0 3.7867 0 0 3.70066 A0A8C0RKM2 A0A8C0RKM2_CANLF Trafficking kinesin protein 1 TRAK1 Canis lupus familiaris (Dog) (Canis familiaris) anterograde axonal transport of mitochondrion [GO:0098957]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; protein targeting [GO:0006605]; vesicle transport along microtubule [GO:0047496] axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; mitochondrion [GO:0005739] GABA receptor binding [GO:0050811]; myosin binding [GO:0017022] ERSKKPGTPGTPGSHDLE;ISAAVYDPQ;QKFIEADYYELDWYYEECSD;VAKVVNSGRAHVPT;VTSAIGGL;YYEECSDV 6 8.1 1.0032 -1.0562 0 0 0 0 0 7.30615 0 0 0 8.34492 0 0 0 0 0 A0A8C0RKM7 A0A8C0RKM7_CANLF WH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779] SSKAPAYNREKPLPP 1 3.8 0.99485 -0.154 0 0 0 0 0 9.37093 0 0 0 0 0 0 0 0 0 A0A8C0RKP2 A0A8C0RKP2_CANLF Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) Canis lupus familiaris (Dog) (Canis familiaris) beta-alanine biosynthetic process [GO:0019483] cytoplasm [GO:0005737] "4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]" AGMCACHS;EEMCINCGKCYMTCNDSGYQ;FEKQEYVGGLSISEI;TEEGPINIGGLQ;VGVANTTVESVN 5 7 1.0019 -1.2593 0 0 0 0 0 6.76009 9.60811 9.55928 0 0 0 0 0 8.85515 0 A0A8C0RKP6 A0A8C0RKP6_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SOHLH2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; neuron projection morphogenesis [GO:0048812] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ELITMMLLV;IRPKLVTIIRSGVKPRKAVRILLN;IRPKLVTIIRSGVKPRKAVRILLNK;LVEGESYVCG;LVYEHQDGSKSL;MDENDGPGE;SIMSFGRDMELEH;SPTSPGSLRKQRSSQHGGSSTSLAS;VLFDQILMGQVDF;YRNGDRYFKGIVYAISPDRFRSF 10 18.2 0.9449 0.07684 0 0 0 0 0 7.46703 0 0 0 6.26273 0 0 0 0 0 A0A8C0RKQ3 A0A8C0RKQ3_CANLF Protein LDOC1 LDOC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CFGWDDDEEDDDDDDE;DDDDDDEEDDY;DEEDDDDDDEEDDY;EEDDDDDDE;EEDDDDDDEEDDY;WDDDEEDDDDDD;WDDDEEDDDDDDEE 7 13.6 0.99774 -0.088824 6.36338 8.98681 0 0 0 3.43883 6.85462 0 1.8984 0 0 0 0 0 0 A0A8C0RKQ6 A0A8C0RKQ6_CANLF Ribosomal protein Canis lupus familiaris (Dog) (Canis familiaris) maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] ALKKLNKNKKLVKKLAKK;DIEALKKLNKNKKLVKKLAKK;EALKKLNKNKKLVKKLAKKYDAF 3 11.6 0.87059 0.14173 0 0 0 0 7.46123 0 0 0 0 0 0 7.17333 0 0 0 A0A8C0RKS6 A0A8C0RKS6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FFPLDIRHNSNMMYIYKRPYVHSP 1 36.4 0.9713 0.041303 0 0 0 0 0 0 0 0 0 8.33686 0 0 0 0 0 A0A8C0RKT7 A0A8C0RKT7_CANLF Spindlin family member 4 SPIN4 Canis lupus familiaris (Dog) (Canis familiaris) gamete generation [GO:0007276] LEQVSVKPTL 1 4 0.99847 -0.61146 0 0 0 8.42412 8.2791 0 0 0 0 0 0 0 0 0 0 A0A8C0RKT8 A0A8C0RKT8_CANLF Protein Wnt WNT16 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] PVRRWLGVA;VRRWLGVAPFGAPEK 2 2.9 0.99189 -0.20662 0 0 5.41082 0 7.36361 0 0 0 0 0 0 0 0 0 0 A0A8C0RKV7 A0A8C0RKV7_CANLF Connexin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling [GO:0086077] CRQTCYDRAFP;GGGGGGGG 2 4.9 0.98407 -0.24721 0 0 0 0 0 0 11.5488 0 0 0 0 0 0 0 0 A0A8C0RKW7 A0A8C0RKW7_CANLF NAD(P)-binding domain-containing protein TGDS Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-sugar metabolic process [GO:0009225] "dTDP-glucose 4,6-dehydratase activity [GO:0008460]" EGTRQASA;KTIDWYRENFHNWKNAEKALEP 2 8.5 1.0024 -1.3691 0 0 0 0 0 0 0 10.1904 0 0 0 0 0 8.95251 0 A0A8C0RKW8 A0A8C0RKW8_CANLF BMP/retinoic acid inducible neural specific 1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to retinoic acid [GO:0071300]; negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025] CQMRNSSLDPMFF;NSEIQNHRPRQ 2 4.9 0.98491 0.035491 0 0 9.47521 0 0 0 0 0 0 0 0 8.72554 0 0 0 A0A8C0RKX2 A0A8C0RKX2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) DCLK2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] PKLVTVIRSGVKPRKAVRILL;SLLLCCCRHEAAVSVEPPRRQQGCR 2 6.6 0.94394 0.083254 0 0 0 0 0 0 7.20036 0 0 0 0 0 6.24447 0 0 A0A8C0RL04 A0A8C0RL04_CANLF S100P-binding protein S100PBP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] calcium-dependent protein binding [GO:0048306] SQDFYLKNLSPLEIPIADLRIFFLY 1 5.6 0.97979 0.035538 0 8.62084 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RL06 A0A8C0RL06_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DGDGDGDGDGDADW;DGDGDGDGDGDADWS;EPGAWAVVAGDEES;GDDGDSDDYDDD;GDDGDSDDYDDDD;GDDGDSDDYDDDDD;GDGDGDGD;GDSDDYDDDD;GGDDGDSDDYDDDDDRE;GGDDGDSDDYDDDDDREREG;IGWSYTGALNQKNWGK;REFLTDGYQ;SPVTTGHSVPPG;STLTSELVYPHELLTSTEG;TLTSELVYPHELLTSTE;VGGGDDGDSDDYDDDDD;VSRATEKSFE 17 5.2 0.98815 -0.4718 0 0 0 8.09671 0 9.02967 0 0 0 0 6.93062 0 5.02751 0 0 A0A8C0RL23 A0A8C0RL23_CANLF ABC transporter domain-containing protein ABCA15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] HIVMVKEAHCNVEEIFKLLQY;IPVYWLSALLWD;METDHMLAAFNLLDKHNA;TLWKLRTFFNQYVYFGIYKTF;TVQGFSSERKFE;VIILLMCMIFFV 6 6 0.94782 0.05044 0 0 0 0 0 0 0 0 11.8512 0 0 0 0 0 0 A0A8C0RL25 A0A8C0RL25_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEEDYYGS;DLETNSMLNDSSSD;DNEVEIEVELD;EAQEMEWLPFR;EVELDREEEPTE;HYQKRHDIDAYYTHCLAASRTI;KFCVRYFRSK;KKEKKKERKRKKKKII;KKEKKKERKRKKKKIIVT;KRKKKKIIVT;KRKKKKIIVTCFYHY;LLNTQTPIYGTE;MNRFQCPFCPF;PAEEVEDSNDSSYSEPPDVQQ;PLCLYHTKY;QQEDAVINVEDDEEEEEDN;RKRKKKKI;RKRKKKKII;TKTKKKQKNKKKEKKKERKRKKK;TKTKKKQKNKKKEKKKERKRKKKKI;TPIYGTEHNNENTD;VGVLVHYQ;YCSFVSAFRHNLD;YTNPIRKGLAAHYQKRH 24 8.8 1.0024 -1.8584 0 0 7.73376 0 0 0 0 3.71875 3.97984 4.39328 0 0 6.69877 6.36349 5.08521 A0A8C0RL57 A0A8C0RL57_CANLF Actin related protein 2/3 complex subunit 1B ARPC1B Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; nucleus [GO:0005634] actin binding [GO:0003779] AECSQFCTTGMDGGM;EVHIYEKSGAKWV;PRSPHPGWVGGAWALAATLV;QNLDKKASSEGSVAS;SNRIVTCGTDRNAYVWTLK 5 15.6 0.68889 0.26744 0 0 0 6.22294 8.84075 0 9.75976 0 0 0 6.63217 0 9.4552 6.42178 0 A0A8C0RL59 A0A8C0RL59_CANLF Neurogenin 3 NEUROG3 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; regulation of dendrite morphogenesis [GO:0048814]; transdifferentiation [GO:0060290] nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AASLEERPGLQ;SDDEGACVASAPPSPARSR 2 14 0.9483 0.085192 0 0 0 7.21781 0 0 9.49404 0 0 0 0 0 0 0 0 A0A8C0RL60 A0A8C0RL60_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] CatSper complex [GO:0036128] calcium-activated cation channel activity [GO:0005227] VIDEIVDTAFEVSQ 1 1.7 0.94096 0.061072 0 0 9.55899 0 0 8.28896 0 0 0 0 0 0 0 8.44361 0 A0A8C0RL69 A0A8C0RL69_CANLF Serine/threonine-protein phosphatase with EF-hands (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) detection of stimulus involved in sensory perception [GO:0050906] calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; phosphoprotein phosphatase activity [GO:0004721] ISLDEFRQ;PISIYYHLTF;RWYRRYMARLE;TTERFLQDSEMEKGSDYESI;YAGQQDQVKLHDFF 5 8.9 1.003 -1.9486 0 0 10.0997 0 0 0 0 0 0 0 0 0 9.18802 0 0 A0A8C0RLC8 A0A8C0RLC8_CANLF C2 domain-containing protein C2CD3 Canis lupus familiaris (Dog) (Canis familiaris) DEPSPVYTQVVENT;DVFSGHQNGSLRV;EIWCRYYYPNVRDQMVARGTLPL;ENRKELRNQSSGL;FQVIPVSLSSK;FSAQGLVPGGGV;GKDFITGESDKQP;GVVKVPTKELLVKRSGVYPLF;IYSSFSFPASDI;LEQGNKLRNAMVISAMKSS;LLMVPDGKDFITGESDKQ;LSPLLSGFQFV;NRNLVEQQM;PLSETYNSYNPLP;PVVDVFSGHQN;SQSSVLKGPEFPENGV;TFAVSILVERAMH;VGLSSPRADQ;VLPNPKSPNP 19 11.2 1.0013 -2.6937 10.4536 12.3882 0 10.9562 6.12848 8.68664 13.4615 10.985 9.61772 0 4.10182 8.45886 11.5651 7.49105 5.85651 A0A8C0RLG8 A0A8C0RLG8_CANLF Vps53 N-terminal domain-containing protein VPS53 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; GARP complex [GO:0000938] GKIKDIKDKAEKSEQMVKEI 1 2.9 0.98187 -0.24931 0 0 0 0 0 0 0 8.29448 0 0 0 0 0 0 0 A0A8C0RLG9 A0A8C0RLG9_CANLF TRASH domain-containing protein ZMYM4 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EEFCCEECMS;ENCGGIMDTEMSEDIDHNLTP;FSVSGSPLAPQLT;LTRILMILFDME;MFCNQQSMCDPPSQNNAAS;MNCCENCGGYCY;MNCCENCGGYCYSGSGQC;NCCENCGGYCYSGS;NCCENCGGYCYSGSGQ;PMIIPSSMDNEDKITES;SIGSELGNSFASNIR;STVSSGGG 12 8.5 1.0022 -1.153 10.5317 6.76035 6.45626 5.3566 6.81096 0 11.4703 7.14364 9.2971 6.9528 0 0 7.84417 0 0 A0A8C0RLH2 A0A8C0RLH2_CANLF Migration and invasion inhibitory protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] EADLGGCGAAEARPCR;LQDAQQDAPCGTSW;SPGAQGGG 3 7.1 0.99127 -0.136 9.32715 0 0 7.59059 0 0 0 0 8.20633 0 0 0 0 0 0 A0A8C0RLH7 A0A8C0RLH7_CANLF Histone deacetylase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) histone deacetylase complex [GO:0000118] histone deacetylase activity [GO:0004407] RRAQVRCRPHHAP;WGLCSSHLGVAEDGLKSEG 2 4.7 0.984 -0.24281 0 0 0 0 0 0 0 0 0 0 7.17493 0 0 0 0 A0A8C0RLH8 A0A8C0RLH8_CANLF Serine and arginine rich splicing factor 11 SRSF11 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] RNA binding [GO:0003723] IQVTNVSP;VPGSAGPG 2 3.3 1.0036 -2.2088 10.8277 0 8.47719 0 0 0 0 11.0713 0 0 0 0 0 0 10.4542 A0A8C0RLJ2 A0A8C0RLJ2_CANLF Rap guanine nucleotide exchange factor 4 RAPGEF4 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] CLDKRPLERSS;DWELFNCVHELELIYHTFGRHNF;FEKFHPNLLHQICLCGYYESLEK;KDMTFTHEGNKTFID;NEIQFWVVTE;RQLNVIDNQR;VFMPNTQL;VGTELVDWMLQQT 8 11.7 1.003 -1.5342 0 0 0 0 0 0 8.67493 10.3121 0 0 0 0 0 0 6.53837 A0A8C0RLL4 A0A8C0RLL4_CANLF C1q domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hormone activity [GO:0005179] SPLTVRSGS 1 2.8 0.98925 -0.20434 0 0 0 0 0 8.70812 0 0 0 0 0 0 0 0 0 A0A8C0RLM2 A0A8C0RLM2_CANLF SWIM-type domain-containing protein ZSWIM5 Canis lupus familiaris (Dog) (Canis familiaris) Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] IDNLKQIYKGKKKLMLLV;IVYWSFPRNERE;PKEALRLTVAIINTLRLQ;QSCALSALTLCEKD;SYLSLALEVALMG;VDALRSHGYPKEAL;VSDMNESRPPVY 7 8.5 0.86945 0.14158 5.03025 11.1747 8.55205 9.20396 0 0 11.1017 9.7752 9.56405 8.27724 0 0 10.3276 0 0 A0A8C0RLN0 A0A8C0RLN0_CANLF Brain abundant membrane attached signal protein 1 Canis lupus familiaris (Dog) (Canis familiaris) EAEGAADGKAEP;PSPPPAPRTPRPPAPPL 2 6.2 0.98801 -0.48369 0 0 0 0 0 0 8.09592 7.84718 8.14924 0 0 0 0 2.95808 9.19451 A0A8C0RLP4 A0A8C0RLP4_CANLF T-complex protein 1 subunit theta (CCT-theta) Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832]; cilium [GO:0005929]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] EAFEAIPRALAENSGV;RAAFPGGFACPSLPPGS 2 5.2 0.9258 0.09546 0 8.85262 7.91552 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RLP9 A0A8C0RLP9_CANLF Radixin RDX Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of organelle assembly [GO:1902115] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; microvillus [GO:0005902]; plasma membrane [GO:0005886] actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839] ENNAEASAELSNDGV 1 5.8 0.9892 -0.19904 0 0 0 0 9.84718 0 0 9.83245 0 0 0 0 0 0 0 A0A8C0RLQ0 A0A8C0RLQ0_CANLF Ras-like protein family member 11B (EC 3.6.5.2) Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] AADCCAGA;GGGVGAGF;IEGETLAI 3 8.8 0.98965 -0.26592 0 0 0 0 0 0 7.36308 0 0 0 7.38491 10.0189 0 0 0 A0A8C0RLQ4 A0A8C0RLQ4_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] pyridoxal phosphate binding [GO:0030170] AELYFRISDLR;CSCSCSCSCSRSC;EVQAPWKQGP;GGPAGSCSCSCSCSC;GSCSCSCSCSCS;PAGSCSCSCSCSC;SCSCSCSCSC;SCSCSCSCSCS;SLHNRLRFL 9 9 0.99696 -0.11145 0 6.27858 0 0 0 0 0 0 0 0 5.507 0 0 5.18015 0 A0A8C0RLS5 A0A8C0RLS5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MEGTLLQIGNNLYCILT 1 21.2 0.98696 0.046227 6.35741 0 0 0 0 0 0 0 0 5.50678 0 0 0 0 0 A0A8C0RLS8 A0A8C0RLS8_CANLF Family with sequence similarity 227 member A Canis lupus familiaris (Dog) (Canis familiaris) CLQLRPNTPATDAIE;FRREKIILQRRLLKKRE;IILQRRLLKKRE;NKLFDRISQNY;PERFRREKIILQRRL;PRAMWLDSFWWIFHERYQPNK;RFRREKIILQRRLLKK 7 12.5 0.9931 -0.17047 8.3447 4.07673 0 5.12631 0 0 0 7.28679 8.67327 0 5.17572 0 9.5947 0 0 A0A8C0RLT3 A0A8C0RLT3_CANLF Optineurin OPTN Canis lupus familiaris (Dog) (Canis familiaris) autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872] DLETMTVL;ELLTENHQLKEAMK;QLKLNSGGPSEDS 3 6.1 1.0033 -1.5791 0 9.9884 0 0 11.7372 0 0 0 0 0 0 0 0 0 0 A0A8C0RLY2 A0A8C0RLY2_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] GEGLEAGSFTCL 1 2.5 0.99076 -0.26842 0 0 0 0 0 0 0 0 0 9.21143 0 0 0 0 0 A0A8C0RLZ1 A0A8C0RLZ1_CANLF RNA helicase (EC 3.6.4.13) DDX47 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] MELREHGEKKKRTREDAGD 1 4.1 0.95038 0.049892 0 0 0 0 0 0 10.0433 0 0 0 0 0 0 0 0 A0A8C0RLZ4 A0A8C0RLZ4_CANLF HMG box domain-containing protein TOX Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677] MWLTCYDRFSVLPTTVFFFFLWLLF;SLVHVNEVEPGYHSLCHP;TTINQSQLSAQLGLN 3 10.7 0.94226 0.083851 0 0 0 0 0 0 0 0 0 0 0 0 6.53711 8.75282 0 A0A8C0RM29 A0A8C0RM29_CANLF Kelch repeat and BTB domain containing 13 Canis lupus familiaris (Dog) (Canis familiaris) PAPVLQPHPAAESGI;SIPACPSGSHCELG;SSYVAVSTHTPAPGF 3 7.3 0.9866 -0.39615 0 0 0 0 0 11.5247 0 0 0 0 0 0 0 9.604 0 A0A8C0RM32 A0A8C0RM32_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) structural molecule activity [GO:0005198] EEKEERIQRRRGKEHEQTPDSSRH 1 9.2 0.97149 0.041303 0 0 0 0 7.97131 0 0 0 0 0 0 0 0 0 0 A0A8C0RM33 A0A8C0RM33_CANLF "Fidgetin, microtubule severing factor" Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AAGYPPQAAVGAGYSP;AALVPGYNGASNLAGYSYPA;DEPLKGAEPH;DIAGLDLVKAVLKEEVLWP;DWGDIAGLDLVKAVLK;GARPGGDSFGKYPS;GVAPALPPADASASIGSSPGVAS;IDESLRRYFMKRLLIPL;YSPGGAPPPPPPSAY 9 17.9 0.95352 0.053903 0 0 0 0 0 9.11134 0 0 0 0 0 0 0 0 0 A0A8C0RM47 A0A8C0RM47_CANLF Telomerase Cajal body protein 1 (WD repeat-containing protein 79) Canis lupus familiaris (Dog) (Canis familiaris) "Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]" LSMRHVHLECQLQLWWC;VEGVSEDLAP;YDYCWYSLMS 3 7.3 1.0033 -0.8862 0 0 0 0 0 0 0 0 0 0 0 0 9.27062 9.14346 0 A0A8C0RM50 A0A8C0RM50_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EVQGQDRSQ;EVTQVMEQDRSHQIRSPSTQSQES;IEHVQTLGGATQ;RQRRSETQSQTREQ 4 11.3 0.98673 -0.42743 0 0 0 0 0 9.27289 0 0 0 11.4887 0 0 0 8.36343 0 A0A8C0RM54 A0A8C0RM54_CANLF "XPC complex subunit, DNA damage recognition and repair factor" XPC Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] nucleus [GO:0005634] damaged DNA binding [GO:0003684] DGDGSVRD;EAAVDKGSCEGDDEEESEDEWEE;GTYKNHPLYALKRHLLKYEA;IDGDGSVRDVTQRYDPA;NWKLLARGLLIRERL;NWKLLARGLLIRERLKLRYG;RWRRRRLDISEDEKPL 7 9.4 0.98458 -0.24613 0 5.86066 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RM56 A0A8C0RM56_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AGELPKRVHQPTES;CQCFEGYILREDG;EQDHGCEQLCLNTEDSYVCQCS;KQADLVFIIDSSRSVNTHD;LVLGQILLVLPA;MTQRMEALENR;NLANEEVRKLTQR;NSYICKCS;RDLLSCSN;VDYCASENHGCEHECVNADSSY;VGDHDCEH 11 16.4 1.0034 -1.1044 0 0 0 5.79163 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RM64 A0A8C0RM64_CANLF 4Fe-4S ferredoxin-type domain-containing protein LOC102151831 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] ACCVPCCCSV;ETLNLTTYTQP;LEPTCCDNCPP 3 32.7 1.0039 -0.82939 4.40149 9.92077 0 0 0 0 0 0 0 0 5.90893 0 0 0 0 A0A8C0RM74 A0A8C0RM74_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) VDPQLYGHLIFDK 1 1.9 0.99141 -0.27003 0 0 0 0 0 0 0 10.0965 0 0 0 0 0 0 0 A0A8C0RM76 A0A8C0RM76_CANLF Nudix hydrolase domain-containing protein NUDT5 Canis lupus familiaris (Dog) (Canis familiaris) nucleoside phosphate metabolic process [GO:0006753]; ribose phosphate metabolic process [GO:0019693] nucleus [GO:0005634] ADP-ribose diphosphatase activity [GO:0047631] GVEGGAST;ISPGGVEGGA;RGRGRSSR;TVTINGDDAENVRPKPKP 4 18.3 1.0031 -1.9328 3.53643 7.67094 9.94796 0 0 8.38068 0 0 10.0388 0 0 0 0 0 0 A0A8C0RM77 A0A8C0RM77_CANLF ABC transporter domain-containing protein ABCA16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EANADDFVHIYSEGN;HKVFVSNDRVYEL;LSFILPKEYTHRF;LVMLPSYNFAMSISKFFNDYEMKKL;MDAFVANYNFLDT;SVVFLDEPSTGLDP;VFLDEPSTGLDPV;WNTITWMCRSK 8 6.8 0.99692 -0.58914 0 0 11.9715 0 0 0 14.1952 0 0 0 0 0 0 0 0 A0A8C0RM85 A0A8C0RM85_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] GGGGGGGD;GGGGGGGG;GGVGGGGG;KGSGGGGG;LPIRVLKMLSAHT;PSAHGGGA;SEELLSHLRTH 7 8.6 1.0027 -0.84916 10.7767 0 0 0 0 0 0 0 0 0 0 0 0 9.50249 0 A0A8C0RM88 A0A8C0RM88_CANLF Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase) ELOVL5 Canis lupus familiaris (Dog) (Canis familiaris) "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]" membrane [GO:0016020] fatty acid elongase activity [GO:0009922] HSSVCADNHPDQLWG 1 5.7 0.98725 -0.2283 0 0 0 0 0 0 0 0 0 0 11.882 0 0 0 0 A0A8C0RMD5 A0A8C0RMD5_CANLF Calx-beta domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell communication [GO:0007154] membrane [GO:0016020] APGRSPNRDWVPM;DSFSFTVT;DSSHTEFYVF;DTDDLMLTFLLEDPPL;ELTLSPDGS;EPKEPGQS;FIPIRRSGDVSQELMVICYT;GAENNRGTNI;GAPGIASRAATG;LLLLLPLL;LLLLLPLLLSPVSRARAQP;LNLEACLWEFVSYYDMSEL;LSYSDYISRPEDHTSVIRFDKDEH;QEKGHHVLSETELRVD;RPLTGPAGSGPQNLVISDED;SHINYVQSVHKGVEPVEDRFI;TNDEQPEIFMREFMVM;TSKGRKKREIRSSPPLAWQIGAE;TYNQPVQQWSF;VPRLPPPLLLLLPLLL;VTRNLPLV 21 9.2 0.99904 -3.2363 9.42293 11.2138 0 0 6.71795 9.08356 13.3749 8.15446 0 10.3411 8.49265 0 8.08236 9.59926 8.1952 A0A8C0RME3 A0A8C0RME3_CANLF WW-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVRWISFKL;IFNRQIIARGLLDILR;LEKAYLRNAGN;SEVRWISFKLVV 4 4.1 0.99378 -0.13046 6.348 0 0 0 0 0 0 0 9.73691 0 0 11.1715 0 0 0 A0A8C0RMF1 A0A8C0RMF1_CANLF Cadherin domain-containing protein LOC485469 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ELDRESQAAYSLE;KTVRYSTFEE;LQELDRESQAAYSLELVAQDG;PVYEVSVRENN;YLSPKKEA 5 5.1 0.98624 -0.45347 0 0 0 0 0 0 0 0 0 8.01357 0 7.81871 0 0 11.6452 A0A8C0RMF3 A0A8C0RMF3_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] FLIKPLPPSTR 1 3 0.9896 -0.214 0 0 0 0 0 0 9.9405 0 0 0 0 0 0 0 0 A0A8C0RMF6 A0A8C0RMF6_CANLF HBV X-transactivated protein 12 C35H6orf62 Canis lupus familiaris (Dog) (Canis familiaris) LHVLSRKDKTGIVVNNPNQSVF;PVQAKFEFHHGDYEK 2 18.5 0.94123 0.10209 0 0 0 3.28591 0 8.99848 0 0 0 0 0 0 9.94711 0 0 A0A8C0RMG1 A0A8C0RMG1_CANLF Platelet-derived growth factor subunit B (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) Canis lupus familiaris (Dog) (Canis familiaris) platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein autophosphorylation [GO:0031954] extracellular space [GO:0005615]; membrane [GO:0016020] growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161] IRTVRVRRPPKGKHRKF 1 7.1 0.98413 0.046227 4.81245 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RMG2 A0A8C0RMG2_CANLF guanidinoacetate N-methyltransferase (EC 2.1.1.2) GAMT Canis lupus familiaris (Dog) (Canis familiaris) creatine biosynthetic process [GO:0006601]; methylation [GO:0032259] guanidinoacetate N-methyltransferase activity [GO:0030731] MELAPPAECRY;SEETWHTHQFNFIKG 2 12.2 0.98668 -0.35747 9.99251 9.97985 10.3078 9.65139 0 10.2632 10.567 0 0 0 0 0 9.93518 9.89156 10.4462 A0A8C0RMG9 A0A8C0RMG9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCPSCCCPSCCL;CCCPSCCLR;CCHPSCCCPSCCCPSCCL;CCPSCCCP;CGTICCHPSCCCPSCCCPSCC;CHPSCCCPSCC;CHPSCCCPSCCCPS;FSCGTICCHPSCCCPSCCC;HPSCCCPSCCCPSC;HPSCCCPSCCCPSCC;ICCHPSCCCPSCCC;ICCHPSCCCPSCCCPSC;PSCCCPSCCCPSC;PSCCCPSCCCPSCC;PSCSMNSCAQPVCCEA;PVCCEATICEPSCSVSSCC;QPVFSCGTICCHPSCCCPSCCC;SCCCPSCCCPSC;SCGTICCHPSCCCPSCCCPSCC;SGCSCESSSCGPQCC;SSCCQPVFSCGTICCHPSCCCPSC;VFSCGTICCHPSCCCPSCCCPSCCL 22 34.2 0.99739 -0.088515 4.60199 9.47974 4.6487 7.74672 6.95687 3.28457 4.62106 6.6293 8.61497 7.44352 5.05107 7.73715 4.46107 8.61198 5.17692 A0A8C0RMH2 A0A8C0RMH2_CANLF "Corepressor interacting with RBPJ, 1" Canis lupus familiaris (Dog) (Canis familiaris) transcription corepressor activity [GO:0003714] KKKKKKKDRKKKKL;KKKKKKKDRKKKKLQK;KKKKKKKK;KKKKKKKKDRKKKKL;KLLRKLDRLEKKKKKK;LDRLEKKK;QKISYDKKKQE;QKQKLLRKLDRLEKKK;QKQKLLRKLDRLEKKKKK;RLEKKKKKKKKDRKKKKLQKSRS;SEGEEDPE 11 11.6 1.0031 -1.4953 11.6587 0 11.5927 8.67009 0 9.21235 4.18761 12.5483 0 0 4.52726 6.26003 13.0135 0 12.505 A0A8C0RMJ9 A0A8C0RMJ9_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP13 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] ALVTIACDAVLSSK;DLDTDDDLNSDDYEYEDE;ELPALVTI;GVDLAAPPGLGRACRLRPPTQ;KMAAGDVG 5 7.2 1.0022 -1.7525 9.9092 0 9.08491 0 0 0 0 0 0 0 0 0 9.64663 0 0 A0A8C0RMK7 A0A8C0RMK7_CANLF Phospholipid/glycerol acyltransferase domain-containing protein GPAT4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] O-acyltransferase activity [GO:0008374] AIVCSVWYLPPMTREG;GVAAQDEMPSCFF;GVLIRYCFLLPLRIAL;HGGLMGVI;LDNTPEFELSDIFYFC;VLIRYCFLLPLRIAL 6 13.1 1.0023 -1.2212 10.7761 10.7161 8.36518 6.05394 9.4947 9.60988 0 0 0 8.17822 0 7.87903 10.6916 8.17343 0 A0A8C0RML4 A0A8C0RML4_CANLF "ERCC excision repair 6, chromatin remodeling factor" Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] EDDSEESDAEFDDFKMPG;EQHKVYQN;KKHIKKLQKRALH;KRLKKHIKKLQ;KRLKKHIKKLQKRALHFQGRVGL;LKKHIKKLQ;NEDTSIFVFLLTT;RGRKVVRCRDDGDE;RMKSDVKMSLSLPD;VLSKTDKRLKKHIKKLQKRA;YQKQDSEIESETSEQSN 11 8.5 1.0019 -1.465 0 6.22693 0 5.29142 3.65924 0 0 10.0768 0 0 0 0 5.6835 10.278 8.85219 A0A8C0RML5 A0A8C0RML5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGVLWLNHREIGHQVCF 1 5.8 0.98488 0.046227 0 0 0 8.83529 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RMM1 A0A8C0RMM1_CANLF Nucleoplasmin core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; single fertilization [GO:0007338] nucleus [GO:0005634] DVSWEEEEEDPEEEEEEEEESHSDE;EEEEDPEEEEEEEEESH;ESHSDEVDDD;PEEEEEEEEESHSDEVDDDDD;VDDDDDDD 5 13.4 0.98768 -0.48253 3.57471 0 0 0 6.11107 0 0 0 6.21998 0 4.80983 0 5.99569 5.08198 0 A0A8C0RMN1 A0A8C0RMN1_CANLF Protein phosphatase 1 regulatory subunit 9A PPP1R9A Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DDDETGEYATDEEEDE;DENNYYQPDMEYSE;DEQEDSDENNYYQPDMEYSE;EQHYAQYDADDDETGEYATDEEEDE;GTEQDEQEDSDENNYYQPD;LDDGQSPKHSQCQN;NDDFSPSSTSSAD;VELEKDEDG;VGSEAAMHQKKELAGG;YDGPSYSKFTETRKMFE 10 9 0.98757 -0.4003 0 0 0 5.35787 0 13.4761 9.13337 8.64111 0 0 10.0863 0 9.36785 7.58331 8.95367 A0A8C0RMN5 A0A8C0RMN5_CANLF RRM domain-containing protein RBM14 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GAPYRGQLASPSSQ;GAQGSSLASYGNQP;PYKKAVAMSKRYC;TTPEELAA;VAMSKRYCMPP;VRAAASSYNTQGA 6 10.5 1.0027 -1.8499 0 12.2951 0 4.32445 0 0 0 0 9.33217 0 9.52476 0 0 0 0 A0A8C0RMR3 A0A8C0RMR3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FLLCPALILHPCCYE 1 10.5 0.94752 0.054534 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5768 A0A8C0RMT1 A0A8C0RMT1_CANLF Phosphodiesterase 6D PDE6D Canis lupus familiaris (Dog) (Canis familiaris) FKLNWMNLRDAETGK 1 16.1 0.98432 -0.24243 0 0 0 0 0 0 0 9.98285 0 0 0 0 0 0 0 A0A8C0RMU5 A0A8C0RMU5_CANLF Olfactory receptor OR5A3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVMKIHSTQGRM;IHSTQGRMKAFNT;IVLIRMESCLHSPMYFFL;VLFVLFLGIYSMTLAWN 4 16.2 0.82284 0.2048 0 0 10.8753 0 5.61035 0 0 0 0 0 2.4147 0 0 0 0 A0A8C0RMX3 A0A8C0RMX3_CANLF Olfactory receptor LOC119864295 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] GGFLSFFIETY 1 3.4 0.99216 -0.14166 19.5317 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RMY3 A0A8C0RMY3_CANLF Anion exchange protein Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] CACMPPDP;DVENADESS;GTKKRRKKKESLRT;IVLPPGEW;KKKKKKKGS;LGDATDNMQGVLESFLG;MILALVAVRKGMDYLFSQ;RVRRTPSVGWL 8 8.6 1.0026 -1.1797 7.29122 0 0 8.04936 0 5.44118 0 10.1292 0 0 0 0 5.69044 0 0 A0A8C0RMY8 A0A8C0RMY8_CANLF F-box protein 6 FBXO44 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AEPASRPVCAPPAPA 1 4.5 0.94944 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 9.158 0 0 A0A8C0RN19 A0A8C0RN19_CANLF FBA domain-containing protein FBXO44 Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein catabolic process [GO:0006516]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005] ubiquitin protein ligase activity [GO:0061630] GRDRGSSTRPPQVIFLR;QQKSDAKWREVSHTFSNY;RGPRLLKARARAPAPP 3 10.6 0.97731 0.048313 0 0 5.80028 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RN55 A0A8C0RN55_CANLF Casein kinase I isoform gamma-1 (EC 2.7.11.1) CSNK1G1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FVQRGPFSHFPAPT;VGSVHVDS 2 5.1 0.94263 0.0611 9.49255 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RN64 A0A8C0RN64_CANLF TLC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" membrane [GO:0016020] KSYPLFSQEF;LRLLPGPDWHV 2 3.7 0.98475 0.035491 0 0 0 0 0 0 6.04481 0 0 0 0 0 0 0 0 A0A8C0RN72 A0A8C0RN72_CANLF Bms1-type G domain-containing protein LOC119866554 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] GTP binding [GO:0005525] AFASEDETEESSSLNTEEED;ARKKHLDKKRKLKE;DDETEDEADTEMMDMM;DEEDESGDSNDEDDEE;DEEDESGDSNDEDDEEM;DEELYGDFEDL;DPCALPEQQK;EDEADTEMMDMM;EDESGDSNDEDD;EEDESGDSNDEDDEEMSEGD;EERDISESKVVGD;ESGDSNDEDDEEMSE;GQLRLAHGVK;IFGDEEDESGDSNDEDDEEM;IKIVKKLKLTGFPYK;KSIKIVKKLKL;MYVRIEIENV;VDSCSDDETEDEADTEMMD;VQSVSDIMP;YPVSIPAF 20 13 0.95532 0.04941 0 5.01078 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RN75 A0A8C0RN75_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC8 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966] palmitoyltransferase activity [GO:0016409] CSHCSVCDNCVEDFDHHCPWVN;NGSLSYDSLLNP;PLAARLKAGL 3 5.8 0.99942 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 5.94657 0 A0A8C0RN83 A0A8C0RN83_CANLF FAT atypical cadherin 1 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AILPLEIFIT;CNCSQDYRGRHCEDAAP;CSDVSACCEVESEVMMSDYESG;DIQIVSLQPSE;EAGNELDLFSLNPNSGVLSLK;ESGDDGHFE;EVQSLSSFQSESCDDNG;FDVVVEVTQEQKP;FIEIYIEVE;GLGEGIGILV;GLITTTSRKLDREQQDEHILE;IIVEDINDNP;IVSGNDDGAFEVN;LFAEYAANV;LKIEARDQAREE;LSTSETLD;NGGTCFDSLDGAVCQCDSG;QFRATKYEVDIGSNAPKGTSV;QVRATDSDSEPNRGISYHM;SACCEVESEVMMSDYESGDDG;TATEDCSSSPCQNGG;TYSIISGNEHGKF;VPVGSSVM;VSACCEVESEVMMSDYE;YLLHVKVADNGKPQLSS 25 7.1 0.98488 0.046227 0 0 0 0 0 5.21642 0 0 0 0 0 0 0 0 0 A0A8C0RN99 A0A8C0RN99_CANLF Golgin subfamily A member 7/ERF4 domain-containing protein CHIC2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886] CETNNMMEYYT 1 7.2 0.9835 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 6.17189 0 0 A0A8C0RNC3 A0A8C0RNC3_CANLF Cadherin domain-containing protein PCDH15 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; sensory perception of sound [GO:0007605] adherens junction [GO:0005912]; catenin complex [GO:0016342]; stereocilium [GO:0032420] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DEELWMGPWNNL;DPGQEYGQDYYSYEH;ESGIDPGQEYGQDYYSYEH;GSSPGEDSAPECQP;GVSEDARMFTS;PYLPRNLSVVEE;SEPVIVNIRVMD;SLGYTEGAL;VEENLPAGTTFLQ 9 6.2 0.99058 -0.53492 14.2561 0 0 0 12.4035 6.14731 0 14.1075 0 0 15.7118 14.2333 14.7116 0 14.9056 A0A8C0RNE3 A0A8C0RNE3_CANLF Angiomotin C-terminal domain-containing protein AMOTL1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AQPAGKVL;EHQVDNTVMEKQG;FKAGGGPSPAQPAGK;PLHSVSLPLPLPMTLAAP;VGECLVGFYESHR;WEQKYLEESTIRHF 6 8 0.93886 0.059825 0 0 0 0 11.4118 0 0 0 0 0 0 0 0 0 0 A0A8C0RNF0 A0A8C0RNF0_CANLF Cystatin LXN-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metalloendopeptidase inhibitor activity [GO:0008191] GVLLVLRPL;PCRIHLVWYPGK;RREDFLLYKRAKRL;TCTRFMETSRS 4 11 1.0021 -1.2177 0 0 0 0 0 0 0 4.34014 0 0 7.68881 0 12.6697 0 0 A0A8C0RNF6 A0A8C0RNF6_CANLF SUZ domain-containing protein R3HDM1 Canis lupus familiaris (Dog) (Canis familiaris) KPTTATACTA;PFCPLQFTSKP 2 3.3 0.99668 -0.57605 7.47249 0 13.8739 0 0 0 7.69537 0 0 0 0 0 0 0 0 A0A8C0RNF9 A0A8C0RNF9_CANLF SPRY domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PAPPTSLSPAHSPA 1 4.8 0.94678 0.078762 0 0 8.82079 0 0 0 7.76162 0 0 0 0 0 0 0 0 A0A8C0RNG4 A0A8C0RNG4_CANLF Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) RET Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] DWIRIEEDTGLLYLNRSLDHSTWEK;ETLVQANG;GLRLLLLLPLLG;ISVSYKLLEGENL;LLLLLPLL;LVQANGSFVRATVHDYR;RAAGLRLLLLLPLLGQAPLGL 7 7 0.98861 -0.26433 0 0 0 0 0 0 0 0 0 9.0709 0 0 10.7106 13.2862 9.361 A0A8C0RNI0 A0A8C0RNI0_CANLF Doublecortin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] microtubule binding [GO:0008017] PVWVSKGEGFSPQELR;SPQELRCTSKEFFW;VIKTMEDYL;VSKGEGFSP 4 7.6 0.98975 -0.19924 0 0 0 7.94246 0 0 0 0 0 0 0 0 0 0 9.46769 A0A8C0RNL0 A0A8C0RNL0_CANLF CUB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905] CDGSWDCAD;CDGSWDCADGTDEE;CEGGAVGGQDGEEAP;DACGDGSDEAGCSSDLFPD;EAPGPSPSMPLEPSLLSG;FTALDLGY;LILRSPLQPQ;LLLLLLLL;NIDACGDGSDEAGCS;PLPVKAPL;TLLLLLLL;TPSAAPLEALD 12 15.9 0.99899 -3.2366 10.9888 0 0 8.89194 0 0 10.2635 8.95029 8.22718 0 6.5097 8.25715 0 0 8.20623 A0A8C0RNL5 A0A8C0RNL5_CANLF Apoptotic protease-activating factor 1 (APAF-1) APAF1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190]; regulation of apoptotic process [GO:0042981] apoptosome [GO:0043293] ADP binding [GO:0043531]; ATP binding [GO:0005524] AEIHTGHH;DQEDCMYWY;GYLKGLGYMRCSTN;LVEEGAATH;PVVFVTRKKL;QEIDVVFQENEVM;SYISFYNALIHE;YDEHSEQVNCCH 8 7.1 1.0031 -2.341 0 3.89152 6.12274 8.40854 11.5767 0 0 0 0 0 0 13.126 13.9277 14.0401 14.1839 A0A8C0RNL7 A0A8C0RNL7_CANLF Tyrosine-protein kinase (EC 2.7.10.2) Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; dendritic cell differentiation [GO:0097028]; DNA damage response [GO:0006974]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; innate immune response [GO:0045087]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of mast cell proliferation [GO:0070667]; neuron projection development [GO:0031175]; platelet degranulation [GO:0002576]; positive regulation of dendritic cell apoptotic process [GO:2000670]; regulation of B cell apoptotic process [GO:0002902]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of mast cell degranulation [GO:0043304]; regulation of platelet aggregation [GO:0090330]; tolerance induction to self antigen [GO:0002513] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; signaling receptor binding [GO:0005102] IRESETLKGSYSLSVRDYD;LPDFSDFP;QTKDPEEQGDIVVALYP;SEEREKSLRNSSTP;VTREEPIYIITEYMAKG 5 14.1 1.0015 -0.91323 0 0 0 0 10.3682 0 0 9.92258 9.3733 0 0 0 0 0 0 A0A8C0RNM2 A0A8C0RNM2_CANLF Galactose-3-O-sulfotransferase 4 Canis lupus familiaris (Dog) (Canis familiaris) glycolipid biosynthetic process [GO:0009247] membrane [GO:0016020] galactosylceramide sulfotransferase activity [GO:0001733] EQGRSAVS;GQSRLESAIAELRARR;PFQFGSGKVLGYVLRSG 3 8.4 0.98595 -0.41483 0 0 0 0 0 0 0 6.14229 0 0 0 0 0 0 9.03221 A0A8C0RNN7 A0A8C0RNN7_CANLF Ribonuclease H2 subunit B (Ribonuclease HI subunit B) RNASEH2B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299] EVVEGKSKVRNE;VTLGLLPLPV 2 6.6 0.9881 -0.22453 0 0 0 0 0 0 0 0 0 9.32069 0 0 0 0 5.32912 A0A8C0RNN8 A0A8C0RNN8_CANLF Protein unc-45 homolog B UNC45B Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; muscle organ development [GO:0007517] A band [GO:0031672]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018] LDADVKDDFVQDIPALQAMFEL;LVVLLCGEDDDKVQNA;NKEVQERFLAD;SEREVDQLVAVEA;YLTLDADV 5 7.5 1.0016 -0.9147 0 7.03947 10.1872 0 7.0813 0 0 0 0 0 9.99124 8.20706 0 0 0 A0A8C0RNQ8 A0A8C0RNQ8_CANLF "Keratin, type I cytoskeletal 17 (Cytokeratin-17) (Keratin-17)" Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cytoplasm [GO:0005737]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] GFGSGFSS;GVGSCGTMSVTSSRFS;LGGGYGGG;LLEGEDAHLTQYK 4 10.4 0.94315 0.059626 0 0 0 0 0 0 0 0 0 0 0 0 7.44882 0 0 A0A8C0RNR6 A0A8C0RNR6_CANLF Neuropeptide Y receptor type 5 (NPY-Y5 receptor) NPY5R Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] ICHLLGMMSCCLNPILYGF;LPVFHSLVELQETFDSAL;VFPFFLIY 3 8.9 0.98734 -0.46318 0 0 0 0 0 8.80726 8.19559 9.35511 10.3637 0 0 0 0 0 0 A0A8C0RNR9 A0A8C0RNR9_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] intermediate filament [GO:0005882] structural molecule activity [GO:0005198] GFGSGFSS;GVGSCGTMSVTSSRFS;LGGGYGGG;QLGELRCD;VEMDAAPGVDLSRILN 5 12.7 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 8.03447 0 0 0 0 A0A8C0RNT9 A0A8C0RNT9_CANLF Leucine-rich repeat-containing protein 41 LRRC41 Canis lupus familiaris (Dog) (Canis familiaris) LSTQAIWRRLWDELMKTRPSSL;RPSSLESVTCWRAKFMEAFFSHVL 2 5.4 0.99073 -0.51501 0 10.6314 0 0 0 0 0 0 0 0 0 0 12.286 0 0 A0A8C0RNU2 A0A8C0RNU2_CANLF Tetratricopeptide repeat domain 31 TTC31 Canis lupus familiaris (Dog) (Canis familiaris) AGGYSCGT;KQKAEKKRLKKKRQ;LMGLQRFEEAA 3 6.2 1.0025 -1.1311 0 0 0 4.10005 0 0 10.6867 0 0 0 0 0 11.0845 0 0 A0A8C0RNV2 A0A8C0RNV2_CANLF ARVCF delta catenin family member ARVCF Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] EGGPELEPD;GAGPHAAT;NFNTLEAAAGALQNL 3 2.7 0.99008 -0.26592 0 0 0 0 0 0 0 0 7.68039 0 0 0 0 0 0 A0A8C0RNV6 A0A8C0RNV6_CANLF MGAT4 family member C MGAT4C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DITQKFAHHIIA;ESFDIPDNPPAN 2 5 0.99028 -0.26679 7.78143 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RNV8 A0A8C0RNV8_CANLF FXYD domain-containing ion transport regulator Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] sodium channel regulator activity [GO:0017080] FKTPHPKKKKKKKKKKKK;HPKKKKKKKKKKKKK;HPKKKKKKKKKKKKKI;KKKKKKKK;KKKKKKKKILP;KKKKKKKKKILPP;KKKKKKKKKKI;KKKKKKKKKKIL;KKKKKKKKKKILP;KKKKKKKKKKILPP;KKKKKKKKKKILPPGSGP;KKKKKKKKKKILPPGSGPY;KKKKKKKKKKILPPGSGPYSF;KKKKKKKKKKK;KKKKKKKKKKKI;KKKKKKKKKKKIL;KKKKKKKKKKKILP;KKKKKKKKKKKILPP;KKKKKKKKKKKILPPGSG;KKKKKKKKKKKK;KKKKKKKKKKKKILPP;KKKKKKKKKKKKILPPG;KKKKKKKKKKKKK;KKKKKKKKKKKKKI;KKKKKKKKKKKKKIL;KKKKKKKKKKKKKILPPG;KTPHPKKKKKKKKKKKKKIL;PFKTPHPKKKKKKKKKKK;PFYYDWESL;PHPKKKKKKKKKKKKKILPPGSGPY;PKKKKKKKKKKKK;PKKKKKKKKKKKKK;PKKKKKKKKKKKKKILPPGS;PKKKKKKKKKKKKKILPPGSGPYS;TPHFPFKTPHPKKKKKKKKKKKKKI;TPHPKKKKKKKKKKKKKI;TPHPKKKKKKKKKKKKKIL 37 42.3 0.021277 1.139 8.52211 7.58826 8.92638 7.80478 6.57365 7.65191 7.22593 8.1954 10.7959 7.41912 5.12346 8.33181 9.05154 5.73761 8.29673 A0A8C0RNW2 A0A8C0RNW2_CANLF G-protein coupled receptors family 1 profile domain-containing protein LOC485221 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LDSTAIAASY 1 3.2 0.98885 -0.26051 0 9.05748 4.38142 3.81445 0 0 9.29188 0 0 0 0 0 0 0 0 A0A8C0RNW3 A0A8C0RNW3_CANLF COP9 signalosome complex subunit 8 Canis lupus familiaris (Dog) (Canis familiaris) COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] AAAGPAGKMPVAVMAE;ATPASRDLP;GQRIWQRDFPGIYTTINAHQ;QRIWQRDFPG 4 11.3 1.0035 -1.5971 0 0 0 8.35733 9.41261 0 0 7.99492 0 0 0 0 0 0 0 A0A8C0RNX2 A0A8C0RNX2_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" nucleolus [GO:0005730] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] LEQGYVVCPSEKR;LLRKKIEKRNLKLRQR;LPFQHMKRAQ;LPMKLLRKKIEKRNLKLRQRNLKL;QIRKKKKKST;RFLLLFTFLKKNRKKKL 6 10.3 1.0035 -1.0543 12.8883 4.99232 4.76384 0 8.66722 0 0 0 0 0 8.10544 0 0 0 0 A0A8C0RNY7 A0A8C0RNY7_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleoplasm [GO:0005654] RNA binding [GO:0003723] NGKVIDPKGP;PKKIREYFGGF;SQNWNQGYSNY 3 13.2 1.0038 -0.8044 0 0 0 0 0 0 0 0 0 0 7.85393 0 0 0 9.98698 A0A8C0RNZ4 A0A8C0RNZ4_CANLF Pericentriolar material 1 protein C-terminal domain-containing protein PCM1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; protein localization to centrosome [GO:0071539] centrosome [GO:0005813] ATSMVTNLEETPI;DMMTDAVNENTKDEETEE;DPQQEPMEEI;EEQDASSNDNFSMYP;GHHTVPGS;ILEGDHGSPAGE;IPFLKEHMDEVCSSQLLTSVRRM;LWSEMRRHEMLREELRQR;MAFPKPFESSSSIGAEKQ;NERSANVERLTHLIDHL;QEERKKLIEIQEKI;QLQEERKKLIEIQEKIQ;SDFSMFEAL;TDAVNENTKDEETEESEYD;VSDQEEDEESEECP 15 9 0.99684 -0.58866 7.14221 0 11.5451 0 9.45882 8.9257 0 13.0985 9.75419 0 0 0 7.11645 0 7.75409 A0A8C0RNZ9 A0A8C0RNZ9_CANLF Apolipoprotein A-II (Apolipoprotein A2) APOA2 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] high-density lipoprotein particle [GO:0034364] lipid binding [GO:0008289] AEEPNLQSLVSQY;FMDLKTQPAT;FMDLKTQPATQ;KAGTDLLNFLSNFMDLKTQPATQ;LNFLSNFMDLKTQPATQ;MDLKTQPAT;MDLKTQPATQ;NFLSNFMDLKTQPATQ;NFMDLKTQPATQ;SNFMDLKT;SNFMDLKTQPATQ;TDYGKDLMEKA;TPLVKKAGTDLLNFL;YFEKTQEQL;YFEKTQEQLTPLV;YFEKTQEQLTPLVKKA 16 66.3 0 28.915 11.9391 11.6425 10.129 11.4073 11.8623 11.9051 13.6208 13.5027 13.5297 12.1263 12.5033 12.303 12.1879 12.3785 12.1222 A0A8C0RP10 A0A8C0RP10_CANLF "Guided entry of tail-anchored proteins factor 3, ATPase" GET3 ASNA1 Canis lupus familiaris (Dog) (Canis familiaris) tail-anchored membrane protein insertion into ER membrane [GO:0071816] endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane insertase activity [GO:0032977]; metal ion binding [GO:0046872] ESVLIIST;ETLPVIRSVSEQ;SLGVAELPDEFFE;VGGKGGVG 4 11.8 1.0036 -2.3884 0 0 10.1819 0 0 0 0 0 0 0 0 0 0 9.65818 0 A0A8C0RP13 A0A8C0RP13_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KLSDMTLPLSL 1 2.4 0.61062 0.35674 0 11.3821 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RP16 A0A8C0RP16_CANLF AP complex subunit beta AP2B1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131] clathrin binding [GO:0030276] ENLDSLDEPD;PVGTTTATNLEQPQV;TNLEQPQVIPSQ 3 3.3 1.0028 -1.1225 0 9.36988 0 0 0 0 0 0 12.0199 0 7.85156 0 0 0 0 A0A8C0RP18 A0A8C0RP18_CANLF Ataxin 7 like 1 Canis lupus familiaris (Dog) (Canis familiaris) LGGPVCHL 1 1.7 1.0044 -1.1044 0 0 0 9.70418 0 9.77693 0 0 0 10.0779 10.1217 10.0736 0 9.90533 9.21544 A0A8C0RP19 A0A8C0RP19_CANLF TGF-beta receptor type-1 (EC 2.7.11.30) (Transforming growth factor-beta receptor type I) TGFBR1 COL15A1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; heart development [GO:0007507]; nervous system development [GO:0007399]; transforming growth factor beta receptor signaling pathway [GO:0007179] activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; membrane raft [GO:0045121] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; SMAD binding [GO:0046332]; transforming growth factor beta receptor activity, type I [GO:0005025]" MIKLALST;VPGATALQCFCHLCTKD;YCCNQDHCNKIELPTVG 3 9.9 1.0025 -1.0119 0 0 7.67659 0 0 0 0 0 0 6.55773 7.97241 0 0 0 0 A0A8C0RP34 A0A8C0RP34_CANLF Importin N-terminal domain-containing protein TNPO2 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267] DAEDDDDDDALSDWNLR;DDDDALSDWNLRKC;DRAQALMDNI;SPSHRPCHV;TQDHDENVALEAC 5 5.9 1.0018 -1.3203 0 0 8.82807 5.32794 0 0 0 0 13.9897 0 0 0 12.2212 0 0 A0A8C0RP40 A0A8C0RP40_CANLF Protein phosphatase 1 regulatory subunit 36 Canis lupus familiaris (Dog) (Canis familiaris) phosphatase binding [GO:0019902] EIEEEIGRL;VFLLWTRAPWLL;VGIKFPAQMQEHME 3 12.7 0.99189 -0.14469 0 0 0 0 0 0 9.60509 0 10.9969 0 0 0 7.8125 0 0 A0A8C0RP51 A0A8C0RP51_CANLF Fibronectin Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; heart development [GO:0007507]; nervous system development [GO:0007399]; regulation of cell shape [GO:0008360] extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; proteoglycan binding [GO:0043394] APSNLRFLATTPNSLL;EATCYDDGKTYHV;FCLCACFFGKYSV;FDEIKATVWTNFATSNLMYTA;GLEPGTEYTIQ;GWGVACCHQSLWL;LSQTTISWTPFQESSEYIIS;PPTDLRFTNIGPDTMRVTW;RFLATTPNSLL;SSKPVSIDYR;TVSDVPRDLE;YSPVKNEE 12 9.4 0.99204 -0.14418 0 11.296 9.24134 0 0 0 0 0 0 0 0 0 9.88559 0 0 A0A8C0RP52 A0A8C0RP52_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;QIILRFVWKQKRPRIARGILKK 5 5.1 0.97404 0.046699 0 0 0 0 0 0 0 0 0 4.48253 0 0 0 0 0 A0A8C0RP69 A0A8C0RP69_CANLF DDHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ECVVFSIDGSFAASVSIMGSDPKVR;LCLTGTGS;LVKFVPCPAV;PYSHDDGCLGNSQD 4 6 1.0027 -1.1629 8.76338 0 0 0 0 0 9.89265 9.40924 0 0 0 9.05311 9.19269 0 7.19239 A0A8C0RP85 A0A8C0RP85_CANLF F-actin-capping protein subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016] actin cortical patch [GO:0030479]; F-actin capping protein complex [GO:0008290] actin filament binding [GO:0051015] KIEGYEDQFDHLR 1 5 0.99151 -0.27003 0 0 0 0 0 8.94971 0 0 0 0 0 0 0 0 0 A0A8C0RP98 A0A8C0RP98_CANLF TGF-beta family profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] NVILRKHRN;PPPPPRGPRRSLC;TFFRASPGP 3 3.8 0.93816 0.059582 0 0 0 0 0 8.06786 0 0 0 0 0 0 0 0 0 A0A8C0RPA7 A0A8C0RPA7_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DHPGVSNQFL;DLLKKFRIP;GVGWWGEF;LPALRTLPP;LPSDFQLISNT;TDRIMAEFFQQGDRER 6 8.2 1.0025 -1.7779 0 14.5316 8.44712 5.11199 0 9.60047 9.25835 0 0 7.31994 7.78103 0 0 7.62673 8.19096 A0A8C0RPD9 A0A8C0RPD9_CANLF LCCL domain-containing protein CRISPLD2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] HYTQYSCW;MEYMTWDEELEQSAA;SYSPKPETDEMNEVEVAPIPE;WGRYRSPGFH;YDEVKDYTYPYPHECN 5 13.4 1.0031 -1.5651 0 7.88387 0 0 0 10.7135 0 0 0 0 0 0 0 9.09075 0 A0A8C0RPG5 A0A8C0RPG5_CANLF Anaphase-promoting complex subunit 4-like WD40 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ARKPERGLAG 1 2.4 0.99928 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 7.55758 0 0 A0A8C0RPJ1 A0A8C0RPJ1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAP4K4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DEVPPRVPV;DLVKNTKGNTLKEDWIAYIS;EARRQQEREQRRRE;FFASVRSGG;FIGTPYWMAPE;GSCAGFHAVDVDSGSVYDIY;IDRTRKKRGEKDE;KKFFSFIE;PQSDTPEIRKY;SSSEESGTTDEEDDDVEQEG 10 10.4 0.98842 -0.4752 9.66702 0 9.86011 10.41 10.0929 9.26336 0 0 0 0 0 0 0 8.99027 0 A0A8C0RPJ6 A0A8C0RPJ6_CANLF "ETS proto-oncogene 1, transcription factor" Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] MCMGRTSSGPIQLW;VPSSEFSE 2 6.6 1.0041 -1.0436 0 0 0 9.93306 0 0 0 0 0 0 0 0 0 6.10073 0 A0A8C0RPK3 A0A8C0RPK3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CTGSTNNIGG;CTGSWAQSVLTQPASVSGS;EDEADYYCQSYDDSL;MGWSPLLLTFLTHCTGSWAQSVLT;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ;YQQLPGKAPSL 11 39 0.98576 -0.4296 0 7.87958 0 0 0 0 9.95755 10.0608 0 0 0 0 0 0 0 A0A8C0RPL6 A0A8C0RPL6_CANLF Negative regulator of reactive oxygen species NRROS Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPELDLTGF;VLSLTFRKPLLRLIKS 2 3.6 1.0029 -0.75498 0 0 5.18396 0 0 7.96446 0 0 0 0 0 0 0 0 0 A0A8C0RPL9 A0A8C0RPL9_CANLF DNA-directed RNA polymerase (EC 2.7.7.6) Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] CLRTGHLPLAHHVLVTHHSRARQQQ;GRLQIERRLRELSNFPQEF;PGSAPAPGSAP;PHPAFTELLAAAAEHTLIFEAAEV;VEMATTVPVE;VHLHSQPILHN;VLHHLPGPAAPAPPLG 7 7.2 0.98538 -0.24606 0 0 0 0 0 0 10.2358 0 0 0 0 0 0 0 0 A0A8C0RPM6 A0A8C0RPM6_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGSGNILLDNVHCRGDEQHLEECSH;IGWFSHNCGHTED;LDNVHCRGDEQ;VICSGKALLPS 4 11.4 1.0026 -1.1505 0 9.36588 0 0 0 0 0 0 0 0 0 0 0 0 8.3692 A0A8C0RPN5 A0A8C0RPN5_CANLF Septin-11 SEPTIN11 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640] axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] ASQQPGRAGIPLSLSG;DLREQTHTRHYELYRR;GPAAALAEGSPPARAPP;GPGLGCAPGPRAAASRPV;KDTDPDSKPFSLQETYEAKRNEFL;LKSLDLVTM;LQESNVRLKLTI;PGGWPCCSGE;RPVRRGKRSAGPG 9 14.3 1.0029 -2.155 10.6803 9.91177 0 6.30781 0 5.37737 0 0 0 0 9.54359 5.44526 0 10.8645 5.05346 A0A8C0RPQ0 A0A8C0RPQ0_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of membrane depolarization [GO:0003254] axon [GO:0030424]; dendrite [GO:0030425]; HCN channel complex [GO:0098855] cAMP binding [GO:0030552]; sodium channel activity [GO:0005272]; voltage-gated potassium channel activity [GO:0005249] DLASAVMRICNLISM;DPEKIKKKYL;FTKILSLLRLLRLSRLIRY;IVRFTKILSLLRLLRL;LRIVRFTKILSLLRLLRLSRLIRYI;RPTAARPA;VDYIFLIV 7 8 1.0029 -1.662 0 0 0 8.65431 0 0 0 0 0 0 5.1668 0 5.59395 6.28995 0 A0A8C0RPQ2 A0A8C0RPQ2_CANLF Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) NFKB1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AALLMDHPNGE;FSDSFGGG;NKDQIKFSFLQMF;RHANALFDYAVT;SGGGGGGA;TALHLAVEHD;VCEGPSHGGLPGA 7 7.7 0.94734 0.084795 0 6.74201 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RPR0 A0A8C0RPR0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AIPQSSHEITLNS 1 22.4 0.9841 -0.24753 0 0 8.85954 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RPR3 A0A8C0RPR3_CANLF AB hydrolase-1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] PPRAAGSPAATSQEL 1 1.9 0.95583 0.053874 0 0 0 0 0 0 9.43212 8.62308 0 0 0 0 0 0 0 A0A8C0RPT3 A0A8C0RPT3_CANLF Latent transforming growth factor beta binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CEDHDECQDMACE;CEDVDECEDL;CEDVDECEDLQ;DGTACEDVDECEDLQSSCQGGE;ECCCQDGEA;EDHDECQDMACENGEC;FCSPPLTLDL;GGRCTNTEGSYHCQC;GLNLTEKIKKIKIVFTP;HDECQDMACENGECVNT;HYNAVHRKCEDHDE;PSPESGECVDIDECANDTMCGSHG;QAECCCTQGASWGDTCDPCPAED;SYHCQCDQ;TTQAECCC;TYTECCCQDGE;TYTECCCQDGEAWSQQCAL 17 9.5 0.97372 0.046811 10.6708 0 0 0 0 0 0 0 0 11.1105 0 9.11567 0 0 0 A0A8C0RPT4 A0A8C0RPT4_CANLF BRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ACEHIFCSNCVSDCIGTGCPVC;EQEEKYEIPEGSH;KEQLLPKLFDGCYFYFGGTFKHHP;NDSPLHNAARNGHLEI;PVCLGACEHIFCSNCVSDC 5 13.1 0.98693 -0.38017 0 4.51488 10.3954 0 0 5.62158 0 12.5392 0 0 0 3.9443 13.9054 4.5114 0 A0A8C0RPV7 A0A8C0RPV7_CANLF Lysyl oxidase homolog (EC 1.4.3.13) LOXL2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] basement membrane [GO:0005604]; chromosome [GO:0005694]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleus [GO:0005634] copper ion binding [GO:0005507]; protein-lysine 6-oxidase activity [GO:0004720] GCWDMYRHDIDC;LAACSSNGWGV;NWGIVEAM;VSLDPVKNVTCENG;YVEVKDGKTWKQICD 5 7.8 1.0026 -1.1779 6.54865 7.71727 0 0 0 0 0 8.86096 0 0 0 14.5031 0 0 0 A0A8C0RPW9 A0A8C0RPW9_CANLF X-prolyl aminopeptidase 1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] CGISYKTFSDEPLEAGM;EALEWLIRETQP;LCELFNWLE 3 6.9 0.98399 -0.24753 0 0 0 0 0 0 10.2109 0 0 0 0 0 0 0 0 A0A8C0RPX1 A0A8C0RPX1_CANLF Anion exchange protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] CYRDGEEYEWKETARW;DLFTEMDELCY;DQVTVLPPGEWDPS;FGGLILDIKRKTPFF;FTKRELSWLDDLMPESKK;KEMNLTAHDISWGNLTVSE;VIHPPEEDLEALKGQEEK;YHEIGRSIATLMTDEIFHDVAY 8 10.9 0.99451 -0.16437 0 0 7.19594 0 0 8.56925 0 0 12.602 9.88979 0 0 9.56102 12.7983 0 A0A8C0RPZ6 A0A8C0RPZ6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SSRSRNCPLCIQVME 1 9 0.98987 -0.21433 0 0 0 0 0 9.97656 0 0 0 0 0 0 0 0 0 A0A8C0RQ10 A0A8C0RQ10_CANLF GPI ethanolamine phosphate transferase 2 PIGG Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] mannose-ethanolamine phosphotransferase activity [GO:0051377] DQATSSSS;PEALSNKA;VLSALHVIVC 3 2.9 1.0001 -2.8202 0 0 0 0 0 8.06996 0 0 0 0 0 0 0 9.42133 0 A0A8C0RQ45 A0A8C0RQ45_CANLF SP140 nuclear body protein SP140 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GKLKRKRRRKKGHAWTRIKRKYQRK;HSESSFFSK;KMRLQELAKIKRSRR;LSDGEAESSSACLEMCDQED;SDEEEPQEALSSPP;VLSDGEAESSSACLEMCDQE 6 10.8 0.99294 -0.048844 0 0 0 0 7.12184 0 0 0 2.99982 0 0 0 6.17257 7.42324 7.30369 A0A8C0RQ58 A0A8C0RQ58_CANLF SAP domain-containing protein MRTFA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] GAPKGPAA;GLDGGGAGENDDE;GPGLIKGV;QQLVEWLRLQLEQE;WHGIEFHLSVG 5 5.3 1.0035 -2.0525 7.80465 10.4339 0 0 0 0 8.13515 0 6.29017 0 0 13.6781 0 0 0 A0A8C0RQ63 A0A8C0RQ63_CANLF RUN domain-containing protein RUBCN Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] endosome [GO:0005768] APPRPQIIFN;EEEDSDREIQE;EERLPEASRREHWQ;NMMSQCLEEEEEEEEDS;PESCNDKS;PRLAELTRAGAAHVER;QELKQKIRLRRQQIRTK;YMSDYEEEPT 8 9.6 1.0016 -2.6836 7.3812 6.7366 11.6612 7.04691 0 0 0 0 0 7.85031 0 9.56834 11.1326 0 10.5954 A0A8C0RQ65 A0A8C0RQ65_CANLF Outer dense fiber protein 1 ODF1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; polymeric cytoskeletal fiber [GO:0099513] CDLYMHPYCCCDLHPYP;MHPYCCCDLHPY;NPCNPCSPCSPCSPCNPCNPCDPCS;NPCSPCSPCSPCNPCNPCDP;SPCNPCNPCSPCSP;TSPCNPCNPCSPCSPCSPCNP 6 18.5 1.0028 -0.77904 0 2.57173 0 0 0 0 0 4.20821 0 5.30382 12.3277 0 0 0 0 A0A8C0RQ69 A0A8C0RQ69_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] AGEVGEDSRHTGPPVLPRP;AIDGAGEEADFHQASADFRRENVLP;ALPALPAVQVPRGRG;ALPAVQVPRGR;EDAFNQIMGYSRKDL;EQEQDQASSETEPSDPAPT;IDSDEEEHEFQQGL;KPGRAPEPVAR;QEQEQEQEQEQEQDQ;SDADLVMLLSLFEEE;TDVLEIEIKDK;VTFVGEEGLDYSGP 12 11.1 0.99019 -0.26712 0 0 0 0 0 0 12.0028 0 0 0 0 0 0 0 0 A0A8C0RQ92 A0A8C0RQ92_CANLF DNA (cytosine-5)-methyltransferase (EC 2.1.1.37) DNMT1 Canis lupus familiaris (Dog) (Canis familiaris) DNA methylation-dependent heterochromatin formation [GO:0006346]; methylation [GO:0032259] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] CPNMAMKEADDDEEVDDNIP;DLIKLAGVTLGKRRAERRQ;EQVESYDEAGDSDEQ;KSTPASYHADI;MHQGKKKKQNKNRISWVGD;PINEWWIT;RQFNTLIPWCLPHTGNRHNHWAGL;VGDGVYLLPEAFTFN 8 8.1 1.0019 -0.71087 10.9609 3.72552 10.4337 0 0 7.68475 9.01628 0 0 0 0 0 11.4282 0 0 A0A8C0RQ95 A0A8C0RQ95_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleus [GO:0005634] RNA binding [GO:0003723] SHFKCLWKKHVIE 1 4.9 0.93924 0.059614 0 0 0 0 0 0 0 9.84576 0 0 0 0 0 0 0 A0A8C0RQA2 A0A8C0RQA2_CANLF Trafficking protein particle complex 9 TRAPPC9 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] EVQLMVYNPMPFEL;KGTHRGWAAVQ;LPIVRRVKLLNLPASLRPQKMK;SGVEFESLP;VGPFALTVAP;YHMSVELLRS 6 6.6 0.98969 -0.52602 0 0 10.3192 0 0 0 8.23955 0 8.69665 0 10.9413 0 0 0 0 A0A8C0RQD0 A0A8C0RQD0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AASSYLSLTPNK;ASSYLSLTPNK;EDEDDYYYCGAD;GVETTKPSKQSNNKYAASSY;ISNIKSEDEDDYYYC;KYAASSYLSLTPNK;NKYAASSY;NKYAASSYL;NKYAASSYLSLTPNK;NNKYAASSY;NNKYAASSYL;NNKYAASSYLSLTPNK;SEDEDDYYYCGA;SNNKYAASSY;SNNKYAASSYL;SNNKYAASSYLSLTPNK;SSYLSLTPNK;STVEKKVAPA;SYLSLTPNK;TTKPSKQSNNKYAASSY;VETTKPSKQSNNKYAASSY;VETTKPSKQSNNKYAASSYL;YAASSYLSLTPNK;YLSLTPNK 24 22.8 0 64.905 14.6344 14.3084 14.4621 0 0 0 13.2818 13.386 12.3938 14.125 14.2269 13.9855 14.4993 14.5011 13.4379 A0A8C0RQE6 A0A8C0RQE6_CANLF Activating transcription factor 6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] LSSSSQMSPLSL;QRRHLLEFSAKEVEDTSD;SEEPDLTAGAGTEG;SVAVVTAFMMKTDQLTFEKAYESLQ;VGSDIAVLRRQQRMIKN 5 8.6 0.97334 0.040942 0 6.67455 0 0 0 7.2503 10.8936 0 0 0 0 0 0 0 0 A0A8C0RQE8 A0A8C0RQE8_CANLF Nuclear receptor binding SET domain protein 2 NSD2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; N-methyltransferase activity [GO:0008170]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] AGEYCQNQCFTKR;CPAGEYCQNQCFT;EKTGSLVLCEGP;GEPGAHDA;MFECHPQVCPAGEYC;NSIICTGHFTA;PAGTELTFNYNLDCLGNE;RSTKTEKPFPEP;VGCPPGRKKSVAST;VSKISSPSDKKIA 10 8.5 0.98598 -0.45217 0 0 8.96812 8.15881 0 0 0 0 0 9.69234 0 0 9.14394 9.96013 6.65793 A0A8C0RQF0 A0A8C0RQF0_CANLF Signal recognition particle subunit SRP72 SRP72 Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] "endoplasmic reticulum [GO:0005783]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312] DLKKKKKKKKGKLPK;IDSAIEVF;KKKGGKGG;KKKKKKKK;LKKKKKKKKGKL;LKKKKKKKKGKLP;LPSSDSMSLKVDVEALE 7 7.9 0.98807 -0.31973 0 3.18252 8.96642 0 0 0 0 0 3.39218 0 0 0 0 10.7283 0 A0A8C0RQF2 A0A8C0RQF2_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) DZIP3 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] DDDDDEEE;IKDLQEVKSKPKKKKK;IQEDSATEDKFYSLDELHILD;NMEPSSSDLSKS;QRIELEELQNEEEELSPPL;RSQDDDDDEEE;VTHMAASNLESL 7 7.9 0.98409 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.73428 A0A8C0RQF3 A0A8C0RQF3_CANLF [histone H3]-lysine(4) N-methyltransferase (EC 2.1.1.364) KMT2C Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] AGPVSSAQ;APADSCTPLPSVSRPAQMT;CSQCGQCYH;DILHTYPSTL;DLLDQERQEQ;ELDPPKTYTQDGV;GNELLKHLLKNKKSSSLL;HYHGMCLDIA;IVQRGERDHTF;KKKRTRKKKK;LDPLLSSSSTPAKPG;LDSGPGPF;LQSLTVTVPRRKRSKPKLKLKII;LYESQNRGV;MDPYAKMVGTPRPAPGGH;MPGVQPQPP;MSGPQQLMIPQ;NLSNPPTP;PEGSFSEDDCTKDNK;PVQQHNILGQAFI;SDTFTRVSPSATRDPYD;SLLSQKPEGS;SLTVTVPRRKRSKPKLKLKI;STPAKPGPHGTTDD;TDPYAKPPDTPR;VGYEASRLYWSTRY;VLGSTQLPAEDVINSCGI;VSSAQSPPHSA;VSSNKDEEENSM;VTVPRRKRSKPKLKLKII;VTVPRRKRSKPKLKLKIINQNSV 31 6.9 0.99692 -6.2224 12.6595 12.5177 7.30223 7.22236 8.67955 10.7283 13.4503 10.1731 13.4895 6.1757 3.79306 7.74631 13.3167 0 13.0238 A0A8C0RQH2 A0A8C0RQH2_CANLF Collagen triple helix repeat containing 1 Canis lupus familiaris (Dog) (Canis familiaris) GSSGLLLLLLLLLLQLR;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLQ;LLLLLLLLLLQLRAP;SGLLLLLLLLLLQ 7 4.2 0.93351 0.10579 0 0 0 0 0 6.16641 0 0 0 0 0 0 0 0 4.62463 A0A8C0RQI0 A0A8C0RQI0_CANLF GDNF inducible zinc finger protein 1 GZF1 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ADARRRRRRRRRRLG;DPTRGRRRRLVRRRGLL;FAENGHFHNLGTVQGSIPTV;PADARRRRRRRRRRL;RGRRRRLVRRRGLLPPRQ 5 6.8 0.73433 0.25049 0 0 7.82776 0 0 0 0 0 7.96913 0 0 0 6.36964 0 3.79546 A0A8C0RQK0 A0A8C0RQK0_CANLF MOSC domain-containing protein MTARC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] LLLPGATEAGGGRRSQEPW 1 5.5 0.95235 0.04981 6.02037 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RQL2 A0A8C0RQL2_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G4B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid catabolic process [GO:0009395] cytosol [GO:0005829] calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]; phospholipase activity [GO:0004620] AGELRRESFSLNPQG;LSDQREALSHGQNPLPIYC;NLSSSDSP;VLFDVGTLQAGELRRESFSL;YHYSKVTYSPEDMD 5 8.3 1.0029 -1.5889 10.6003 10.0462 9.11405 0 0 0 12.3919 9.4113 10.5675 0 0 0 0 0 0 A0A8C0RQL8 A0A8C0RQL8_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LLLLLPLL;SSPSSLCPW 2 3.7 1.0036 -0.80421 0 0 0 0 0 0 0 0 5.75344 9.89168 9.58062 0 9.72083 5.71559 0 A0A8C0RQN0 A0A8C0RQN0_CANLF Protrudin (Zinc finger FYVE domain-containing protein 27) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum tubular network formation [GO:0071787]; neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axon extension [GO:0045773]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; growth cone membrane [GO:0032584]; recycling endosome membrane [GO:0055038] metal ion binding [GO:0046872] AGGKCALP;DEGAPCPAE;HYCHHFTDQKTEVQ;PARHLHKSFPVFLLKYEIW;VGALMISV;YQAREHYCHHFTDQ 6 13.7 0.85138 0.17113 0 8.70179 0 5.94598 0 0 0 0 0 0 0 6.79909 0 0 0 A0A8C0RQP2 A0A8C0RQP2_CANLF Coiled-coil domain containing 159 CCDC159 Canis lupus familiaris (Dog) (Canis familiaris) CCCSSPLPSNVCLP;PSWDSDSDSDQD;RTPEPEILGPAPENTVPGI 3 11.1 0.85582 0.17141 0 0 0 9.2104 0 0 0 0 0 0 0 0 0 0 5.525 A0A8C0RQP4 A0A8C0RQP4_CANLF Interleukin 18 binding protein IL18BP Canis lupus familiaris (Dog) (Canis familiaris) interleukin-18 binding [GO:0042007] LSWLLTAKQCPALEV 1 7.8 0.95387 0.053888 0 0 8.21936 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RQP8 A0A8C0RQP8_CANLF Ryanodine receptor 3 RYR3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AWKEILNLLYKLLAALIR;CCRFLCYFCRISRQNQKAMFEH;CQSGEDEEEEEDK;EEEEDEDSSYMLEIE;EEEEEDEDSSYM;GGEGWGGNGVGDDLYSYGF;GLGDIMNNKVFY;IEECLLAICNH;IISTVDYL;IRNTTALFSQF;ISLAKARY;LINDVTSIRPNIFLGVAEGSAQYKK;NILKIINN;PEEEEEEDEDSSYMLEIEG;PLIRPFKT;PTTLKELISQTMI;QCLEPLQMMALH;SEIIGKDEP;SHKKYDPD;SKEIKEKLDSSHKRDIEG;SSMMAKSCQSGEDEEEE;TERSKLEDDPLY;TPYRSTTWPTICEC;VDVLELCEQEDLMYFHYHTLR;VRHRISLFGSDSTTMVSCLH;YHILCSLYSLGTGKNIYVER;YMLEIEGEEEDS 27 7.2 0.99061 -0.26725 0 0 0 0 0 9.48591 0 0 0 0 0 0 0 0 0 A0A8C0RQQ1 A0A8C0RQQ1_CANLF DNA damage-inducible transcript 4-like protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] cytoplasm [GO:0005737] KQENCSWTSFRDFFFSRGRFSSGL;RETEPLTMVA 2 14.8 0.81108 0.2135 0 0 9.01313 0 6.01015 0 7.98664 0 0 0 0 0 9.02323 9.42261 0 A0A8C0RQS7 A0A8C0RQS7_CANLF Keratin 85 KRT81 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] EFVVLKKD;GVGSCASSC;VGSCASSC;VGSVNVCV 4 4.7 1.0025 -2.1745 0 0 0 0 0 0 6.6768 7.83289 0 0 0 0 5.33764 0 0 A0A8C0RQW3 A0A8C0RQW3_CANLF RAS p21 protein activator 3 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] APSWTFSTSGD;RAGPPVSPHPESRGVCICHV;VAATCPGSCWECCPGSG;VVYTEDHVFSSDYY 4 7.4 0.98621 -0.41574 12.4789 0 0 0 0 0 9.05341 0 0 0 9.16985 0 0 0 0 A0A8C0RQY0 A0A8C0RQY0_CANLF Kinetochore protein Spc24 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] kinetochore [GO:0000776]; nucleus [GO:0005634] EVAQCLLDAKE;LLDAKEQAHQRGV 2 9.1 0.98999 -0.21393 0 9.55654 0 0 0 0 10.1383 0 0 0 0 0 0 0 0 A0A8C0RQZ1 A0A8C0RQZ1_CANLF Cystatin domain-containing protein LOC485559 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity [GO:0004869] DQKTMEIFLSATVEYALHVFN;IITCFFTISTDPWNTIFE;PWNTIFELWNKTCLE 3 31.5 0.9974 -0.090694 0 0 0 0 0 0 0 0 10.2504 10.189 0 0 6.38754 0 0 A0A8C0RR03 A0A8C0RR03_CANLF Thrombospondin-like N-terminal domain-containing protein COL16A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] DPIFSGMPGP;EPGADGAAGKEGPPGKQG;GAEGEPGA;GGPPGPKG;GHCNPSDCFGAMPMEQQYPP;GLKGEKGDPC;KGSSGVPGKEGPGGKPGKP;LSKPQDEDGYVVALPGPP;PGGKPGKP;RGYIGPPGE 10 7.5 0.99904 -3.2035 7.38379 13.8867 10.9834 9.45949 0 0 8.65349 0 0 9.62651 6.96313 0 11.064 5.29858 0 A0A8C0RR09 A0A8C0RR09_CANLF GPALPP motifs-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) DDDDDDDDEGFFG;DDDDDDDDEGFFGP;HVLSGREKRLAE;KRSESLMD;NQDDDDDDDDDE;QDDDDDDDDD;QDDDDDDDDDEGF;YEEENQESEEDDTG 8 14.5 0.99577 -0.56546 6.16318 0 0 0 0 6.59356 12.5933 0 0 10.2758 0 4.45562 0 8.50561 0 A0A8C0RR10 A0A8C0RR10_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] DLTPKRRRELIKIRA;ELNEIETRRTMQQINR;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 8.7 0.93867 0.10311 0 7.36868 0 0 0 0 0 0 0 0 0 0 0 0 8.32863 A0A8C0RR22 A0A8C0RR22_CANLF Alpha-2-macroglobulin like 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ANRLVLQQETLPSIPGVY;DVVEPKQLSTVE;EANYNIGTVNS;EFIFIDDK;ITFEDTKNFYYPNF;NKNFQHTFSI;NYLKDCIRVQ;TAYITAALLE;TVGLTAFKPFF;YRMFSFWYGHYPYQV 10 8.2 0.9987 -3.2688 0 0 9.79876 10.5245 0 0 9.78275 0 0 3.17505 11.8784 11.2827 8.47102 0 0 A0A8C0RR26 A0A8C0RR26_CANLF Mesenteric estrogen dependent adipogenesis Canis lupus familiaris (Dog) (Canis familiaris) GPAAARGGFNVF 1 4.2 0.95267 0.05044 0 0 0 0 8.84605 0 0 0 0 0 0 0 0 0 0 A0A8C0RR32 A0A8C0RR32_CANLF Tropomyosin alpha-4 chain (Tropomyosin-4) TPM4 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin filament [GO:0005884] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] AGLNSLEAVKRKIQALQ;AKHIAEEADR;EIKLLSDKLKEAETRA;KTIDDLEEKLAQAKEENVGLH;LQKLEEAEKAADESERGM 5 33.1 0.95644 0.050838 0 0 0 0 0 0 0 10.5522 0 0 0 0 0 0 0 A0A8C0RR37 A0A8C0RR37_CANLF Microsomal triglyceride transfer protein large subunit MTTP Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] lipid binding [GO:0008289]; lipid transfer activity [GO:0120013]; phospholipid transporter activity [GO:0005548] DVQGGLAIDISGA;IAVFAEEIH 2 2.5 0.99314 -0.2831 0 11.8094 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RR41 A0A8C0RR41_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) establishment of protein localization to plasma membrane [GO:0061951]; fertilization [GO:0009566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens morphogenesis in camera-type eye [GO:0002089]; protein localization to cell junction [GO:1902414]; retina morphogenesis in camera-type eye [GO:0060042]; symbiont entry into host cell [GO:0046718] adherens junction [GO:0005912]; apical junction complex [GO:0043296]; cell-cell contact zone [GO:0044291]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; postsynaptic density membrane [GO:0098839] cell adhesion molecule binding [GO:0050839]; protein homodimerization activity [GO:0042803] GGALFIVLVSVLAG;GRRITCVVKHP;SPPGAGLPLPPPTPPPPLLLLLFP;VISRREWYV;VIYISDPPTTTTLQPTIQWH;WSRLDGQWPDGLLASDNTLH 6 17.8 0.9942 -0.078005 0 11.837 0 8.39956 0 0 12.6175 0 14.5965 0 0 0 0 5.60946 0 A0A8C0RR53 A0A8C0RR53_CANLF DNA topoisomerase 2 (EC 5.6.2.2) Canis lupus familiaris (Dog) (Canis familiaris) DNA topological change [GO:0006265]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]" DFSEEEDDDADDDDDNNDLEE;DKNMTCIKVSIDP;EDDDADDDDD;EDDDADDDDDNN;EEDDDADDDDDNNDL;FSEEEDDDADDDDD;FSEEEDDDADDDDDNN;IEVVKKKN;KAGGGGAG;KEYFADMERHRILFRYAGPEDDAAI;LVGMLGAEST;MAGKAIKGKVGKPKVKKLQL;MAKAGGGG;QVYKEQVLEPMLNGTDKTPALISD;SEEEDDDADDDD 15 8.6 1.0015 -2.6706 9.84177 7.6178 9.86521 8.03837 10.1482 5.50195 6.45139 4.4002 0 9.87441 0 0 12.6148 9.82521 3.44055 A0A8C0RR60 A0A8C0RR60_CANLF RHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097] cytoplasm [GO:0005737] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AASGAMASG;EQLSDSFAFEFFQG;GRSAGSIPGEH;GRVPRPPD;RMEAPSMSSADLYGISDGNM 5 7.3 0.98665 -0.42748 10.9612 0 10.8166 0 0 0 0 0 0 9.86391 0 9.93549 9.68519 9.93821 0 A0A8C0RR77 A0A8C0RR77_CANLF "Keratin, type II cytoskeletal 7 (Cytokeratin-7) (Keratin-7) (Type-II keratin Kb7)" KRT86 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] DIEIATYRKLLEGEESRCGELHWRR;EFVVLKKD 2 7.4 0.97717 0.035538 7.00966 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RR79 A0A8C0RR79_CANLF Potassium voltage-gated channel subfamily Q member 4 KCNQ4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated potassium channel activity [GO:0005249] ELANECLLILE;PNLPWTVLLWS;RSVRILKFLVAKRK;SVRILKFLVAKRKFK;TVQVPLFDPDI 5 6.6 0.99358 -0.064001 8.30278 0 0 0 0 9.92037 0 0 0 6.04616 5.68122 0 0 0 0 A0A8C0RR98 A0A8C0RR98_CANLF Angio associated migratory cell protein AAMP Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] SMGGLNPARASSWPSFTAHSILWDI 1 5.3 0.99198 -0.29482 0 0 0 0 0 0 10.5836 0 0 0 0 0 0 0 0 A0A8C0RRA4 A0A8C0RRA4_CANLF Aldehyde dehydrogenase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cellular aldehyde metabolic process [GO:0006081] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" ETEPVMQEEIFGPILPIVNVG;KDSYPQGDRARSR;SPSLGRVVSDKHFRRLR 3 8.2 0.85308 0.1566 0 0 0 0 6.27238 0 0 0 10.8391 0 0 3.33285 0 0 0 A0A8C0RRB4 A0A8C0RRB4_CANLF Olfactory receptor OR2Z3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ELSLSISGVLILLLPL;ILLFLIHT 2 7.6 0.98944 -0.21643 0 0 0 0 0 5.67945 0 8.27947 0 0 0 0 0 0 0 A0A8C0RRC5 A0A8C0RRC5_CANLF Acetylcholine receptor subunit epsilon CHRNE Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] DTEAYTENGE;KIDIDTEAYTENGEWA;VGSSVIFLGGYFNQVP 3 6.5 1.0018 -0.74306 0 0 0 0 0 8.77149 9.49025 0 0 0 0 0 10.0778 0 0 A0A8C0RRE3 A0A8C0RRE3_CANLF Phosphoglycerate kinase (EC 2.7.2.3) Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] cytoplasm [GO:0005737] ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] KGVLFLKD 1 3.2 1.004 -1.1044 0 0 9.02281 0 0 0 0 0 0 0 8.74143 0 4.18031 9.23649 8.88823 A0A8C0RRE5 A0A8C0RRE5_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; hormone binding [GO:0042562] AAASRNLTRREE;CDEGKCIPESL;CDGHADCPDGSDEM;DCGDSSDEDACASCPDGMV;ECPDGSDEQCEE;EDCADGSDEGGKCSSLLSACSQ;GVNDCGDSSDEDAC;GVNDCGDSSDEDACAS;GVNDCGDSSDEDACASCPD;GVNDCGDSSDEDACASCPDG;GVNDCGDSSDEDACASCPDGM;IVFPTKKSLYWVNRGKK;KDPQKAKHLPCS;LLLLLLLP;LSQQGSNSCSKDNGGCSHMCLP;MFLLPSGTCSEL;RRALLLLLLLPRVLA;SGGQPCSQTC;TGIEPILLVAVQS 19 9.2 0.95602 0.053874 0 0 0 0 0 0 4.11861 4.06247 0 0 0 0 0 0 0 A0A8C0RRI0 A0A8C0RRI0_CANLF Maestro heat like repeat family member 5 (gene/pseudogene) Canis lupus familiaris (Dog) (Canis familiaris) HSQEEFRHPPGA;LILQAEDNST;PQEPHLPQEPHL 3 2.5 0.9919 -0.1849 8.10292 0 0 0 0 0 0 0 5.88267 0 0 0 0 0 0 A0A8C0RRL8 A0A8C0RRL8_CANLF Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) PIN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255]; regulation of primary metabolic process [GO:0080090] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GVGTTWLEEPL 1 7.5 0.9823 -0.25051 0 0 0 0 0 0 10.399 0 0 0 0 0 0 0 0 A0A8C0RRM1 A0A8C0RRM1_CANLF Ribosomal RNA-processing protein 12-like conserved domain-containing protein RRP12 Canis lupus familiaris (Dog) (Canis familiaris) DMGVRSKKHQ;IDGSEENLDFPRSWLL;LPSFASGHQPF;LPSFASGHQPFPWWP;LVNIRKAEARAKRHRALNQ 5 4.4 1.0021 -0.652 10.9148 10.1149 0 0 3.27149 0 0 0 0 0 9.62846 0 0 0 0 A0A8C0RRM4 A0A8C0RRM4_CANLF Cytochrome P450 family 4 subfamily F member 8 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" DVHLWWIG;FLYYLTPDGQRF;FNRSADIMHAKWKR;LLHPNLSHCFCLWKSLGSPLLS;LTLLRFRVL;LVHNFTDAVIQER;VIPKGVTCLISIF;VLTWSYSFYDNCCR 8 16.4 0.99898 -2.9484 0 9.66327 0 9.54363 5.241 0 0 0 0 0 0 0 9.09294 6.98493 0 A0A8C0RRM6 A0A8C0RRM6_CANLF Solute carrier family 30 member 10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic cation transmembrane transporter activity [GO:0008324] EPAPRRCRALS;VTIQFEQVDLKDPVE 2 3.9 0.99106 -0.13422 0 0 0 0 0 0 0 11.1148 0 0 0 0 0 6.55033 0 A0A8C0RRN2 A0A8C0RRN2_CANLF Olfactory receptor OR8S9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FCEFQVIPHFSCELPSLFPL;FILLGLSVDSHIQ 2 10.6 0.92299 0.11544 0 0 0 0 0 0 0 10.9535 0 0 0 0 9.91069 0 0 A0A8C0RRN3 A0A8C0RRN3_CANLF Mucin-2-like Canis lupus familiaris (Dog) (Canis familiaris) ASSPAAPTKTVHSTGP;MSASSTSSVTTTSHLVI;TISNHPPRTVTSKP;TPSPSPHSPS 4 8 0.93848 0.062581 0 0 0 0 0 0 0 0 0 0 0 0 0 9.21977 0 A0A8C0RRR2 A0A8C0RRR2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ECILLAFMAY;LVSTAWFFG;VGFEQSSSSTRALL 3 9.9 1.0036 -1.6482 9.68484 0 0 0 0 8.31583 0 7.16922 0 0 0 0 0 9.88891 0 A0A8C0RRR5 A0A8C0RRR5_CANLF Sodium channel protein SCN8A Canis lupus familiaris (Dog) (Canis familiaris) membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228] axon [GO:0030424]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] ALAFEDIYIEQRKTIRT;AQAAAMATSAGTVSEDA;EISKLSSKSAKE;EQPKYEDNI;ETMWDCMEVAGQAMCL;FSWAFLALFRLMTQDYWENLYQLTL;IDEDHMSFIN;IRLARIGRILRLIKGA;IRRIAIKILIH;KEKQQRAEEGRRERAK;KLKKPPKA;LALLQVPDEQPKY;LSPFNLIRRIAIKILIHSVF;MFALRHYYFTIGWNIFD;PEVEEVPVE;QLKKQQEEAQ;RVIRLARIGRILRLIKGAK;SELGAIKSLRTLRALRPLR;SENEFADDE;SRHNSKSSIFS;VEHNWFET;VGAGYLAL;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGIRTL;VIRLARIGRILRLIKGAKGIRTLL;VLRSFRLLRVFKLAKSWPTLN 27 14.6 0.99793 -3.3307 11.0183 9.33242 0 11.8097 6.72629 5.77616 8.72229 5.37612 0 10.2413 9.60624 8.59279 9.88153 7.96446 10.6465 A0A8C0RRR7 A0A8C0RRR7_CANLF Coiled-coil domain containing 184 Canis lupus familiaris (Dog) (Canis familiaris) DVISAEYN;PVGSPPPSGASSSLGP 2 6.5 1.0019 -1.3058 0 0 0 0 0 0 0 0 0 0 8.47792 0 0 0 0 A0A8C0RRS4 A0A8C0RRS4_CANLF UBA domain-containing protein UBAP2L Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] APGLLHAYPPQ;DLKNPNDSTVHSP;PHQQPHSQILHHHLQ;QDGQLPYLQMILCCQRQQEEQ;TTTSSWDMGSASQSP;YPSSISSSPQKDLTQAKNGFSSVQ 6 9 1.0022 -1.2963 0 0 0 0 0 0 10.8596 7.12143 0 0 0 0 0 9.71284 0 A0A8C0RRS5 A0A8C0RRS5_CANLF SEA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] IKIKIYIILQL;PKIKIKIYIILQLKEGIKK;PRCYCLSTDTDWY;RCYCLSTDTDWYSGETCE;WDGIKCVCVGLFQ 5 14.1 0.9479 0.084901 0 0 0 0 0 0 0 0 4.83461 0 0 0 4.68801 0 0 A0A8C0RRT3 A0A8C0RRT3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) GKEEFKLSLFADMILYIENP;MDAFLESHKL;MNEKGEITTNT 3 4.6 0.95092 0.049802 0 0 0 0 0 0 0 0 0 0 10.907 0 0 0 0 A0A8C0RRT9 A0A8C0RRT9_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) scavenger receptor activity [GO:0005044] AQACSCHEDSC;CDGNSTCS;PPSGLEQP;QELNPRGR;RCERYCQCFRGRCHPVDGTCACE;RCPPCRDGHACNHVT;VAVCDGNSTCSENEV 7 10.1 1.0034 -2.2804 0 6.08888 0 5.93697 9.86584 0 0 0 0 12.0474 0 10.8271 4.29359 0 0 A0A8C0RRU1 A0A8C0RRU1_CANLF RALBP1 associated Eps domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] ISYSSTSIEEAMK;PELSYIWEL;RQPLVQPEGPS 3 5.6 0.98902 -0.21849 9.36737 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RRW1 A0A8C0RRW1_CANLF Hormone-sensitive lipase (EC 3.1.1.23) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (Retinyl ester hydrolase) Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; triglyceride catabolic process [GO:0019433] caveola [GO:0005901]; cytosol [GO:0005829]; lipid droplet [GO:0005811] lipase activity [GO:0016298] AETPANGYRSLVHT;AGRWSQVATPWAGSVPPPGLSPQD;EDNMAFFSSQGP;FTSGRFAID;PSEPHGPTAAP 5 12.1 0.98775 -0.37543 10.5128 10.8047 0 0 0 0 0 8.51629 0 0 0 10.78 0 0 0 A0A8C0RRW9 A0A8C0RRW9_CANLF Fork-head domain-containing protein FOXJ3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LRMTSELESSLT;LSEIYQWICDNFPYY;SQGGVGVVFDLGYGVDFNP 3 24 0.98671 -0.23041 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.8469 A0A8C0RRX2 A0A8C0RRX2_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] GTPase activator activity [GO:0005096] EVTEEEKINAAQ;LVISVSLISWPSL 2 10.9 0.99334 -0.55664 0 8.05295 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RRX6 A0A8C0RRX6_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LTLVKVLVF;VQVQEENEGNEAQV 2 3.5 1.0038 -1.0592 0 0 0 0 0 0 0 5.86617 0 10.7442 0 0 0 0 0 A0A8C0RRZ2 A0A8C0RRZ2_CANLF "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86)" INPP5D Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376]; phosphatidylinositol dephosphorylation [GO:0046856] cytoskeleton [GO:0005856]; membrane [GO:0016020] phosphatase activity [GO:0016791] GVSFMFNGTSLGFVNSH;PESSPQEDVQLTKPEMFENPL;PSRSELSQQPPPPPA 3 4.5 0.99223 -0.050896 5.60606 0 0 0 0 0 10.6562 0 0 0 0 0 0 0 0 A0A8C0RRZ3 A0A8C0RRZ3_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GPSTMICFLV;GWNLSSFNNL;LATKAFTLVKVLVL;LVLLLIGLLTLRITEFSLATKAFT;VLSFIIMSGFIK;VLSFIIMSGFIKGDLH 6 11.2 1.0026 -1.1228 0 0 0 8.75642 8.35151 0 0 8.80958 8.87566 0 6.14777 0 10.287 0 0 A0A8C0RS02 A0A8C0RS02_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477] membrane [GO:0016020] LETFIQEHLRVIGAVGI;PGCGQRDH;PPGSRVRRAAPGWAE;QQEFHCCGSNNSQ;RRNLLRLYFILLLIIFLLE 5 9.8 1.0019 -1.2321 0 0 4.72208 10.6379 0 11.7182 0 0 0 0 0 7.47905 0 6.41226 0 A0A8C0RS13 A0A8C0RS13_CANLF L-lactate dehydrogenase (EC 1.1.1.27) LDHA Canis lupus familiaris (Dog) (Canis familiaris) lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] GAVGMACA;PCILGQNGISDVVKVTLT 2 8 0.9895 -0.21761 0 9.25736 0 0 0 0 5.06022 0 0 0 0 0 0 0 0 A0A8C0RS37 A0A8C0RS37_CANLF Ku domain-containing protein XRCC6 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; telomere maintenance [GO:0000723] Ku70:Ku80 complex [GO:0043564] ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; telomeric DNA binding [GO:0042162] EDLLRKVRAKETRKRVL;EPEQAKDLTLPKIEA;FLLFFSPIGEYTYS;GTEKDKNSVNFKNIYVL;IFLDLMHLKKRGGFDI;TKAGDLRDTGIFLD 6 14.5 0.91889 0.11472 0 8.31402 0 0 0 0 0 0 0 0 6.87983 0 0 0 0 A0A8C0RS44 A0A8C0RS44_CANLF Sex comb on midleg-like protein 1 SCML1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] NSEEVECCCCT;SMFSPTRASTATPGAMM 2 7.2 0.99038 -0.20152 0 7.53652 7.70694 0 0 0 0 0 0 7.55888 7.51144 0 0 0 0 A0A8C0RS53 A0A8C0RS53_CANLF Apoptosis antagonizing transcription factor Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GSDEDAMSAAEEEEYDNDRDSSL;ILQKWHDRT;MLPQAPAN;PLRARARARARARPRGRRPSL;QPDVFPIFKDK;RKLEMEDYPSFMAKRFADFTVYRNR 6 13.7 1.0016 -0.75234 12.0398 0 4.55293 0 10.5695 10.4645 0 10.4354 7.47435 0 3.90169 8.06501 0 0 0 A0A8C0RS55 A0A8C0RS55_CANLF MCF.2 cell line derived transforming sequence like Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DEFWAKHQQKLQQC;EEEGRVGPRKLVPGKY;HLFLHEKAVLFCK;IYHFHNRIFLRE;LHEKAVLFCK;PPEKGRGW;YVEELLCV 7 6.2 0.99913 -3.128 0 9.65701 0 0 0 0 13.4215 11.9946 13.0574 0 0 0 6.52058 0 8.57626 A0A8C0RS94 A0A8C0RS94_CANLF Triple QxxK/R motif-containing protein TRIQK Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ISNSSKKKQPRAL;QPRALLLVSGIE;SIFNVSIYSI 3 14.6 0.99247 -0.15122 0 0 7.53823 0 0 0 0 0 0 10.5081 0 0 7.87166 0 0 A0A8C0RSB8 A0A8C0RSB8_CANLF 14-3-3 protein zeta/delta Canis lupus familiaris (Dog) (Canis familiaris) EGAEKKQQMVREYREKIENE 1 14.7 0.97196 0.048206 0 0 0 6.99333 6.94498 0 0 0 0 0 0 0 0 0 0 A0A8C0RSG3 A0A8C0RSG3_CANLF InaF motif containing 2 INAFM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPEEDEEEAAAAPGS 1 9.9 0.98887 -0.26245 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.019 A0A8C0RSG6 A0A8C0RSG6_CANLF RNA helicase (EC 3.6.4.13) IGHMBP2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; zinc ion binding [GO:0008270] EFVASEKTQLEFPP;ERRGGGGAQVLAGK;MWVHQIAE;PPGSRPQEGAQEGAQEARA;RKRKRKRRE;RQTQDRREKSSVWN 6 7.5 1.0021 -1.2468 9.3736 0 0 0 0 0 0 0 0 7.09645 9.5808 0 8.604 0 0 A0A8C0RSI5 A0A8C0RSI5_CANLF SSD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLSPQTADYQVPS;GASPDDLDETEQTVP;HTLIFFDLWRLSKSQ;LFLTLMVL;LNTAEALFLSAS;LSHRPSVLSEDLQLH;LVAFFLYRVAFRMAYFPFV;MMVKCVSCGFASFF;PAPRCRAHWLGPSSATPS;PPATSTLQPVRPTSPLA;SCCPHSGP 11 8.9 1.0033 -1.6096 14.0555 0 0 9.98698 0 10.1401 10.2498 8.70089 0 0 11.7014 11.321 10.1083 8.68559 9.29678 A0A8C0RSI8 A0A8C0RSI8_CANLF Neuronal-specific septin-3 SEPTIN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent cytokinesis [GO:0061640] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; presynaptic cytoskeleton [GO:0099569]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] LDTARTDTAMA;NGGLPPNKAMCLT;PFAVVGSDK;PGRGKPRARGI;PVLRKTISLDTF;RVLGRKTPWGI 6 8.5 1.0031 -1.7091 0 11.7566 0 0 0 0 0 7.98197 0 10.5324 0 0 0 0 0 A0A8C0RSI9 A0A8C0RSI9_CANLF Coagulation factor VII F7 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] AADGDQCASNPCQ;KNWKNLTGEHD;LDRGATAL;VGGKVCPKGECPWQ;YTDHVVPLCLPEKTF 5 16.1 0.94382 0.059561 0 0 0 0 0 0 0 6.1638 0 0 0 0 0 0 0 A0A8C0RSM1 A0A8C0RSM1_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Rho protein signal transduction [GO:0035025] membrane [GO:0016020] lysophosphatidic acid receptor activity [GO:0070915] DTIQNSIKMKNWSAKRSDFRFS 1 6.4 0.97444 0.046947 0 0 0 0 0 0 0 8.20203 0 0 0 0 0 0 0 A0A8C0RSM3 A0A8C0RSM3_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP11A Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AAPSMDGPLLKD;DIVMVKEDET;FYFLIIFLVQL;GTCHVTTASLDGESSH;IWPFLNYQRMY;PGAEAYILQRH;SGSLTRDNFSGLSADMQDYG;THYWTWINH;VTSGLPLF 9 10.1 1.0029 -2.4901 0 4.05224 0 0 0 8.83488 0 0 11.7501 10.1893 10.1893 11.7991 0 11.723 10.0666 A0A8C0RSM4 A0A8C0RSM4_CANLF DH domain-containing protein PLEKHG6 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] GQHPPSPTHTDSAGESPWE;LDPVSLQNGFLTFSQRFQPY;PYEVLEPSSEEVEKLDVY;QAPQRRSAPELP;TELTYVRKLKIM 5 10.7 0.98893 0.028242 0 8.04226 0 0 0 9.1706 6.15036 0 0 0 0 8.10114 0 0 9.50559 A0A8C0RSM7 A0A8C0RSM7_CANLF BLOC-1-related complex subunit 7 BORCS7 Canis lupus familiaris (Dog) (Canis familiaris) BORC complex [GO:0099078]; membrane [GO:0016020] GPSSSPLSRLRRSLVEV 1 13.6 0.98469 0.046227 0 0 0 5.70786 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RSN5 A0A8C0RSN5_CANLF Adaptor related protein complex 1 associated regulatory protein Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of cell motility [GO:2000146]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; vesicle targeting, trans-Golgi to endosome [GO:0048203]" cytosol [GO:0005829] AP-1 adaptor complex binding [GO:0035650] EEALYAAQREAARAAKQ;LYSSEFFFL;RMEGRIERIVNIFLVD;SGNDDSTSLDLEWEDEEGMN 4 21.7 1.0024 -0.90008 9.35096 0 8.30916 0 0 0 10.4306 0 0 0 0 0 0 8.07248 0 A0A8C0RSN7 A0A8C0RSN7_CANLF G-protein coupled receptors family 1 profile domain-containing protein MRGPRD Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EDSLLAYEVMQRMKYFAYTVSLGLL;ETLSTAPS 2 9.7 1.0037 -1.0689 0 0 5.82607 0 0 0 0 0 0 0 0 0 0 0 8.92065 A0A8C0RSP1 A0A8C0RSP1_CANLF RUNX1 partner transcriptional co-repressor 1 RUNX1T1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] EDALAVINQQEDSSES;EEAVNEVK;KTPSRLTPP;QEKRRKKRPN;WAEEWKHLDHLLN 5 9.4 1.0037 -0.8317 10.8144 9.53772 0 0 8.65374 8.69881 3.21397 0 0 8.5755 0 0 0 0 0 A0A8C0RSP4 A0A8C0RSP4_CANLF "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Steroid 17-alpha-monooxygenase)" CYP17A1 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" KLILLEATIREVLRIR;LPLVTMDILSD;NCVKMRDDLLNEILE 3 9.2 0.87337 0.12922 0 0 0 0 0 0 0 0 0 9.70727 0 0 0 0 10.2339 A0A8C0RSQ2 A0A8C0RSQ2_CANLF Carbonic anhydrase (EC 4.2.1.1) CA4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] TTMKESISL 1 2.9 1.0045 -0.80421 0 0 0 0 0 0 9.5713 0 0 0 0 0 0 0 0 A0A8C0RSR1 A0A8C0RSR1_CANLF FAD-binding FR-type domain-containing protein OXNAD1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] GVGERQSLAAAG 1 4.1 0.95348 0.05044 0 0 0 8.28072 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RSR3 A0A8C0RSR3_CANLF UDENN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641] late endosome [GO:0005770]; recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] ADELEALQMCCQQV;CDCSTFPEAEAM 2 11 0.86103 0.15256 0 0 0 0 0 0 0 13.3088 0 0 0 0 0 0 5.94486 A0A8C0RSU8 A0A8C0RSU8_CANLF Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) MGME1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial DNA repair [GO:0043504] membrane [GO:0016020]; mitochondrion [GO:0005739] single-stranded DNA exodeoxyribonuclease activity [GO:0008297] DLKERDENLECGY;FQVRTLNLYLCKA;GLDPGSPGSHPGLKAVLNR;SRRFSLEPTAHV;VIDWKTSEKPKPYIRN 5 19.5 0.68371 0.26902 5.89023 0 0 0 7.24679 7.24508 0 8.4099 0 0 0 0 0 8.03359 0 A0A8C0RSV2 A0A8C0RSV2_CANLF Leucine zipper like transcription regulator 1 AIFM3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]" EAQVVTVDVRNKK;NLEMNVTVQ;PEQLALRP 3 2 1.0022 -1.3608 0 0 11.2374 0 9.94087 0 0 0 0 0 0 0 0 0 0 A0A8C0RSW1 A0A8C0RSW1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GGAGGPGAVDRPDPFRLPDG 1 3.4 0.97497 0.048206 0 0 0 0 0 0 0 0 0 0 0 4.29748 0 0 0 A0A8C0RSY7 A0A8C0RSY7_CANLF Ig-like domain-containing protein CD19 Canis lupus familiaris (Dog) (Canis familiaris) B cell proliferation involved in immune response [GO:0002322]; regulation of B cell activation [GO:0050864] membrane [GO:0016020] ALGPEDEDSFSSAAESYENEDEEL;DEDSFSSAAESYENEDE;EDADSYENMD;EPDSEEGSEFYENDSNRGQD;LETRRNNFHLPSLDF;LHLRRALILRRKRKRMT;PGPSHEEDADSYENMDNPN 7 14.4 0.98729 -0.32403 8.81253 9.57314 0 0 0 0 8.93216 5.4939 8.52482 0 4.96125 4.23993 5.3749 0 0 A0A8C0RT17 A0A8C0RT17_CANLF Cytochrome P450 (EC 1.14.14.-) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" IVGTSRNKYRWWEEDRTGKEH;LLYMSLNPDIQEK;PPLLLLLL 3 8.2 0.9497 0.049735 0 0 0 0 7.51546 0 0 0 0 0 0 0 0 0 0 A0A8C0RT33 A0A8C0RT33_CANLF Chromatin assembly factor 1 subunit A CHAF1A Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260] nucleus [GO:0005634] DDDEVGEDEDEDDGFFVP;DEVGEDEDEDDGF;EEEPGESLSHSEGDDDDEVGE;PIRRITKKLIK;QADTEEEEEEDGD;SEGDDDDEVGED 6 5.8 0.99195 -0.036305 12.5511 0 12.496 0 0 0 12.3634 0 12.5923 12.6233 6.30504 12.6673 12.2051 12.5354 0 A0A8C0RT55 A0A8C0RT55_CANLF Inosine triphosphatase Canis lupus familiaris (Dog) (Canis familiaris) nucleoside triphosphate catabolic process [GO:0009143] nucleoside triphosphate diphosphatase activity [GO:0047429] GATSPPPQ;HALWWHRKLTCRST;PAFPGLGP;REPGARWSAAPPAAA;WSSESAWRPPWRGKRSCLSP 5 14.5 1.0027 -1.193 10.9025 8.3213 0 0 0 7.57811 9.43825 9.77905 4.19975 0 0 0 7.51262 0 0 A0A8C0RT59 A0A8C0RT59_CANLF Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) ITPA Canis lupus familiaris (Dog) (Canis familiaris) deoxyribonucleoside triphosphate catabolic process [GO:0009204]; nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; nucleoside triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166] GATSPPPQ;REPGARWSAAPPAAA;RRKLRRPVPRQRKCLPLE;VTGNAKKL 4 10.6 0.99195 -0.17976 0 0 0 0 0 0 0 0 0 0 0 0 0 6.83289 7.67737 A0A8C0RT78 A0A8C0RT78_CANLF Multimerin 1 MMRN1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] FSQGSYRYAPMVA;ISLAVSDVRNTY;PTVNLTTVLIGRN;SIHLSVHF;SLNILIKELSKRHNLL;TEQMNYQAMK;VTEEYSDCSS 7 6.8 1.0024 -1.8426 0 0 2.06343 0 0 7.88289 12.4615 0 5.79922 11.4581 0 0 0 0 0 A0A8C0RT92 A0A8C0RT92_CANLF "SDS3 homolog, SIN3A corepressor complex component" Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826] HLTPCGKR;KERIRNAELF;VHSDAISSGF 3 5.9 1.0034 -1.6387 10.628 10.4119 0 0 0 0 11.255 11.0734 11.7163 12.2058 10.4438 10.1767 11.1263 0 0 A0A8C0RT96 A0A8C0RT96_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] EASPCCQQSSCQPSC;ESSPCSQQSSCQPSCCSSSP;LVCCKPVCCESSPCCQQSSCQPSCC;QPSPCRPS;VCCTPVCCKPVCCE 5 16.8 0.94251 0.083744 0 0 0 0 0 0 4.45398 0 0 0 0 0 9.29434 0 0 A0A8C0RTA6 A0A8C0RTA6_CANLF KRAB domain-containing protein ZNF862 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] FYKFERGPEPWLGNV;KPGWVVGL;LLEEWLGLKAIAKNLPFSMLC;LYMEEAVTQK;VVDACGGI 5 5.4 1.0032 -2.131 7.37478 0 0 0 0 0 9.07452 0 13.2682 7.55382 0 0 8.68499 0 0 A0A8C0RTB0 A0A8C0RTB0_CANLF Protein NDRG3 (N-myc downstream-regulated gene 3 protein) NDRG3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] RACAAAEPSPPLSQPLPL 1 4.3 0.98068 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 7.18706 0 A0A8C0RTB2 A0A8C0RTB2_CANLF G protein-regulated inducer of neurite outgrowth C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LDEALTMPASQH;SLDGGARAD 2 2.7 1.002 -0.75377 0 0 8.68475 0 0 0 0 0 0 0 0 7.96636 0 0 0 A0A8C0RTB9 A0A8C0RTB9_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CCCCCCCCCC;CCCCCCCCCCH;CCCCCCCCCCHRC;CCCCCCCCCCHRCR;CCCCCCCCCH;CCCCCCCCCHR;CCCCCCCCCHRCR;CCCCCCCCCHRCRRG;CCCCCCCCHR;DIPVYQVILNKE;GVRPSCCCCCCCCC;GVRPSCCCCCCCCCCHR;GVRPSCCCCCCCCCCHRC;GVRPSCCCCCCCCCCHRCRRG;HICAGTLI;PSCCCCCCCC;PSCCCCCCCCCCHRC;PSCCCCCCCCCCHRCR;PSCCCCCCCCCCHRCRRGP;RGVRPSCCCCCCCCCC;RPSCCCCCCCCC;RPSCCCCCCCCCCHRC;SCCCCCCCCCCHR;SCCCCCCCCCCHRCR;SCCCCCCCCCCHRCRR;VRPSCCCCCCCCC 26 7.3 1.0022 -1.4492 11.1844 4.39094 7.69544 8.89203 9.21016 10.5696 9.08255 9.5441 0 4.92177 7.26547 7.17772 5.99754 2.92913 6.40688 A0A8C0RTC8 A0A8C0RTC8_CANLF Ecotropic viral integration site 5 like EVI5L Canis lupus familiaris (Dog) (Canis familiaris) DQIEELKAE;GEAVASARELKL;RRRKEKLLKELIRKGIPHHFRAIV;TENRLLKQ;VGVGVGAA;YPEHEFFKGQD 6 9.3 0.98992 -0.26592 0 0 0 0 0 0 0 0 0 0 17.6964 0 0 0 0 A0A8C0RTD8 A0A8C0RTD8_CANLF "Suppressor of glucose, autophagy associated 1" Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] extracellular space [GO:0005615]; membrane [GO:0016020] ADANGFSA;ARLSVLPQVGKDGVPRDGDGATALP;DAVCDCSTQ;DYLKDEIEELRAEMLEM;EDSADLKCQ;GGGCGGAE;GGGGGGGA;GGGGGGGG;MQRSYTAPDKTGIRVYYSPPV;RPPASPEEPSVAASSVGS;SKSWSPRSSSL 11 7.2 0.99709 -3.9291 0 0 0 10.5979 5.85567 0 9.24043 6.50484 10.1869 8.26247 6.82222 8.6986 6.51806 6.61745 6.7137 A0A8C0RTH0 A0A8C0RTH0_CANLF Checkpoint kinase 2 CHEK2 Canis lupus familiaris (Dog) (Canis familiaris) mitotic DNA damage checkpoint signaling [GO:0044773] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DEDMKRKFQNLLSEEKKS 1 3.7 0.97665 0.048313 10.1285 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RTH6 A0A8C0RTH6_CANLF peptidylprolyl isomerase (EC 5.2.1.8) Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GSAQARRRRSPAHGPGGRGGS 1 6.4 0.99086 -0.19524 0 0 0 0 0 0 11.5432 0 0 0 0 0 0 0 0 A0A8C0RTJ1 A0A8C0RTJ1_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480] basolateral plasma membrane [GO:0016323]; intracellular membrane-bounded organelle [GO:0043231]; lateral plasma membrane [GO:0016328]; presynaptic membrane [GO:0042734] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] AYSVKKMMK;DPVRPEVP;RRMKRKRKRKVRLAVSVRI;SELSIEQWLW;VFLFYCFYYCG 5 5.6 0.9473 0.084901 0 0 0 0 0 6.6886 0 4.82655 0 0 0 0 0 0 0 A0A8C0RTK3 A0A8C0RTK3_CANLF Synphilin-1 alpha-Synuclein-binding domain-containing protein SNCAIP Canis lupus familiaris (Dog) (Canis familiaris) LDEIDFSDDISDNNR;NMTPFCVLSPV;NMTPFCVLSPVKSPHL;PENQSKDFL 4 3.9 0.98554 -0.4324 0 0 0 0 0 0 0 0 10.7076 0 0 9.96824 0 0 0 A0A8C0RTK9 A0A8C0RTK9_CANLF Cytochrome c domain-containing protein CYC1 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" mitochondrial respiratory chain complex III [GO:0005750] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GLKMLMMMGLLF;LSYITRARHG 2 6.8 0.98696 -0.49948 0 0 0 0 0 0 0 0 10.0993 0 0 0 11.9877 0 0 A0A8C0RTP2 A0A8C0RTP2_CANLF Zinc finger protein 212 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CGYCGKSF;EQEWENLDD;SSRQVQLGQE 3 5.4 1.0033 -2.2179 0 0 10.8424 0 0 0 8.13484 0 0 0 0 0 0 0 0 A0A8C0RTQ8 A0A8C0RTQ8_CANLF HECT domain-containing protein HERC5 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] AVYEEFQRGFYK;HYWTESSENNYH;HYWTESSENNYHV 3 3.8 0.98788 -0.47733 11.6968 0 0 11.386 0 0 13.7543 0 0 0 14.3742 0 0 0 0 A0A8C0RTR8 A0A8C0RTR8_CANLF ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) CARKD NAXD Canis lupus familiaris (Dog) (Canis familiaris) metabolite repair [GO:0110051]; nicotinamide nucleotide metabolic process [GO:0046496] mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453] KGERDVISDGKQGPA 1 4.8 0.9529 0.053884 0 0 0 0 10.5065 0 0 0 0 0 0 0 0 0 0 A0A8C0RTS4 A0A8C0RTS4_CANLF "RAB20, member RAS oncogene family" Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] SAGGYLSAPA 1 2 0.99906 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.74933 A0A8C0RTS9 A0A8C0RTS9_CANLF Nucleosome assembly protein 1 like 5 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDEEEYEDEEEGEEEEEEEEEEE;EEDDDDEEEYEDE;EEDDDDEEEYEDEEEGEEEEEEEE;GEEDDDDE;TLEGEEDDDDEEEYED 5 17.2 1.0019 -0.90804 5.52196 0 0 0 0 0 0 7.40659 0 8.00349 0 0 0 5.31459 0 A0A8C0RTU4 A0A8C0RTU4_CANLF Beta-adaptin appendage C-terminal subdomain domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131] GGGGGGGA;GGPGREGA;VHGERIPNAPYVL 3 3.9 0.99296 -0.18776 0 0 0 0 0 0 10.7209 0 0 0 0 0 0 0 0 A0A8C0RTU9 A0A8C0RTU9_CANLF "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (EC 4.1.1.32) (Serine-protein kinase PCK1)" PCK1 Canis lupus familiaris (Dog) (Canis familiaris) dicarboxylic acid metabolic process [GO:0043648]; gluconeogenesis [GO:0006094] GTP binding [GO:0005525]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613] FGENSRVLEWMFNRINGEA;IMHDPFAMRPFFGYNFGK;NWFRKDKEG;PKIFHVNWFRK;QLQNGLNFSAK;SPTPPRELSPPTSPRCRMTS 6 14.2 0.96384 0.048688 6.98607 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RTW5 A0A8C0RTW5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) AIRNDKYPPL;WNQKRPRIARGILKKKTR 2 3.8 1 -0.61146 0 0 10.9281 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RTW9 A0A8C0RTW9_CANLF ASH1 like histone lysine methyltransferase Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872] EERFAFGHHYFRPHE;EHYLCEQC;HFVHPREQLSEVSLE;IDEIVGETAS;KMKRQKRKRKKKYPQLRSRQD;NTCPCGEQCCNQ;PAAPSDSCSSS;TLVGSRDPDLKDRALLN 8 3.7 1.0026 -0.77606 0 0 0 0 5.84935 0 6.39577 4.94771 0 0 8.15725 7.35535 0 5.6457 11.0881 A0A8C0RTX0 A0A8C0RTX0_CANLF Syntabulin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAAAARGPG;EDWIEEECHRVEAQ;LGSHSSSCLI;LSSRTGTPC;QLSPLSSR;VGFCPGSDEDFSRKKCTI 6 10.4 1.0029 -1.3284 0 11.0375 9.82459 0 0 0 9.56348 10.0657 9.16518 9.88021 10.8767 0 9.80266 10.9386 10.1625 A0A8C0RTY1 A0A8C0RTY1_CANLF Cyclic nucleotide-binding domain-containing protein HCN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated potassium channel activity [GO:0005249] FTKILSLLRLLRLSRLIRY;IVRFTKILSLLRLLRL;LRIVRFTKILSLLRLLRLSRLIRYI;LVPVRAGPLLARGPWASTSRLP;TSSVAIAL;VLEEFPMMRRAFETVAMDRL 6 10.2 0.98591 -0.45239 12.172 0 11.9847 8.97656 0 0 0 0 0 0 0 12.0931 12.1948 0 0 A0A8C0RTZ6 A0A8C0RTZ6_CANLF Chloride intracellular channel protein Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; cytoplasm [GO:0005737] chloride channel activity [GO:0005254] LLPKLHIIKI;NSPLPDEIDAYSTED;NYLNSPLPDEIDA 3 11.3 0.98904 -0.52262 0 0 8.52572 0 0 0 0 0 14.6948 0 0 0 8.12335 8.18488 0 A0A8C0RU14 A0A8C0RU14_CANLF Tectonic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] CCCDQECSS;CPCNLTANACDVRCCCDQ;DVRCCCDQECS;DVRCCCDQECSSD;VSLAGQCMQ 5 4.9 0.99176 -0.54269 0 0 5.77276 0 7.61993 0 0 0 0 0 0 0 0 0 0 A0A8C0RU18 A0A8C0RU18_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK3 Canis lupus familiaris (Dog) (Canis familiaris) desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled receptor signaling pathway [GO:0007186] postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; G protein-coupled receptor binding [GO:0001664]; G protein-coupled receptor kinase activity [GO:0004703] EDYALGKDCI;EVKEHIFFKGIDWQ;FCQWKNVELNIHLT;HASVGTHGYMAPEVLQK;IKEYEKLENEEDR;QFVLQCEFVI 6 12.2 1.0021 -0.98718 0 0 0 8.29398 0 0 0 0 0 0 0 5.8223 11.3031 0 0 A0A8C0RU47 A0A8C0RU47_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APGLEEEREAQKP;ETKDMLYIVTEFAKNGEMFDYLT;GPAAGHPPAHQPHRGPPSRRHA;TKDMLYIVTE;YDEQVLGIMHTLGI 5 9.8 0.98396 -0.23829 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5438 A0A8C0RU49 A0A8C0RU49_CANLF Sulfotransferase (EC 2.8.2.-) SULT1B1 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] aryl sulfotransferase activity [GO:0004062] YHFDLMNNLEPAPGPW;YKKEMSGSTLQ 2 9.1 0.98728 -0.40478 0 0 0 0 0 9.18537 0 0 0 0 0 0 12.1064 0 0 A0A8C0RU51 A0A8C0RU51_CANLF Myb-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] ALPDVEEEEE;DDSSDEEYQPD;DDSSDEEYQPDDEEEDETAEES;DEDILERDPLREQKD;DIHLEEDDSSDEEYQPDDEEED;DLTADEEEE;EDDSSDEEYQPDD;EIKPPQFV;ESERRRRKRKGSKRKRDAR;ESVLCTVRRNQAG;ETEDMPMFE;EVTCGSPLGQSEACGSTDGQV;NEDEADDDDDP;NQLCVEDP;PDNIIKFYKKTKQ;PLLLPKGVVLKL;QEGESEEENSQEENSEPEEE;RITKKEVNELMEELFETF;SASEESVLSVPE;SRKAWRQKRPAVLKPLLI;SSEMTETDEEGSML;VILTMCQEKGAQPQ 22 12.3 1.0014 -2.6848 0 4.04701 0 9.86825 11.2245 0 8.5047 0 7.05028 9.57365 7.75422 6.65076 7.8069 9.90167 8.53648 A0A8C0RU65 A0A8C0RU65_CANLF Myosin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ATFEELCHNYAHERL;PAHLGSLAK;QEPERRQQPRALPHSGTPPSVW;RFAMVMSLDFNATGRVTAAQLQ 4 7.8 0.97356 0.048134 0 0 0 0 0 0 0 9.88759 0 0 0 0 0 0 0 A0A8C0RU68 A0A8C0RU68_CANLF RAVE complex protein Rav1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEEELLNMLPAMQKED;ATYKSILRKKVL;DDDDDDDDDDDD;DDDDDDDDDDDDVL;DDDDDDDDDDVLASDFHLQ;DDDDDDVL;DELFQIPTL;DSEESLESDDDDDDDDDDDDD;DSEESLESDDDDDDDDDDDDDV;ESDDDDDDDDDDDDD;ESLESDDDDDDDDDDD;HPLQLLELMDLGKVRRAK;ITSLSLSENNEKSGP;KFNGIRKELARKEMIKK;KRCLNESLEDNCET;LESDDDDDDDDDDDDDV;NPGDHCFSVGSVGDQRFTAY;RCRNERMNLEYVWEEWPLLIEDGL;SDDDDDDD;SDDDDDDDD;SDDDDDDDDDDDD;SELARINSLHVSAFS;SLESDDDDDDDDDD;SLESDDDDDDDDDDDD;SLESDDDDDDDDDDDDDV;TDSLSTLDENDIL;WHVDWLDEYQPGM;WSKNADMLFSI;YCSDGEDL;YDSEESLESDDDDDDDDDDDDD;YVMHTLAA 31 8.1 0.98632 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 8.34256 0 0 A0A8C0RU82 A0A8C0RU82_CANLF ADAM metallopeptidase domain 12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AEQSGGIVMDH;EECDCGEPEE;EQGEECDCGEPEEC;EQGEECDCGEPEECMNLCC;GHNFGMNH;GVCNNRKNCH;HCEAHWAPPFCDK;HDGHPCQGVDGYCY;SLSTCSGLRGLIT;VEQGEECDCGEPEECMN;VEQGEECDCGEPEECMNLCCN 11 10.7 1.0035 -1.6991 9.40886 0 0 3.25529 0 0 10.96 5.68874 11.1845 3.88938 0 0 8.83219 9.6935 0 A0A8C0RU89 A0A8C0RU89_CANLF RHD domain-containing protein NFATC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EAKLDRDLCKPN;GYGGAVDT;PNLEAYRDPSCLSPASSLSSRSCNS;SLTGFSVPPHFCPGNVLQ;TDNSLELDGV;TLSLQVASNPI;VEKQSAASCPVLGG 7 12.8 0.98541 -0.24076 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0247 A0A8C0RU92 A0A8C0RU92_CANLF Nuclear receptor corepressor 2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654] DNA binding [GO:0003677] AGKLEPVSPPSPP;INQAMRKKLILYFKRRNH;NNSSDTESIPSPRT;TPPPEDALVSSEPGPA;VAEEEEQKPPVAQEMAVDMGKTEEP;YKSLVRRSYR 6 3.8 0.98685 -0.3561 0 5.85047 7.75995 7.99803 0 0 0 9.75962 8.23223 0 6.50247 9.52638 8.0621 0 0 A0A8C0RUC4 A0A8C0RUC4_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IGRSRSRRRRRRRP;LAYSLGMTGEPGQGVV;PPIFWPGVVQGSPWRDP 3 11 0.86905 0.16182 0 0 4.85005 0 0 0 4.64593 0 0 0 0 6.94275 0 0 0 A0A8C0RUC5 A0A8C0RUC5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] LTISSLQL;TWSDYYTLYWYKQPPGGEMIFLI 2 25.8 0.98911 -0.21482 0 0 0 0 0 0 10.2957 0 0 0 0 0 0 0 0 A0A8C0RUD5 A0A8C0RUD5_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SLC22A3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] transmembrane transporter activity [GO:0022857] LISCFGVG;LLPETKGIALP;SCRRYLLE;VVELPAAL 4 6.4 1.0033 -2.439 0 0 0 0 0 0 8.42681 0 0 0 0 0 9.37012 0 14.0577 A0A8C0RUE1 A0A8C0RUE1_CANLF Ribosomal protein L26 like 1 RPL26L1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273] cytosolic large ribosomal subunit [GO:0022625]; organelle membrane [GO:0031090] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KVVLIRLKLDKDRKKILERKAKS;VGIHLSKVVLIRLKLDKDRKKIL 2 20.4 0.93609 0.092506 0 0 0 4.4064 0 0 0 0 5.1247 0 0 0 0 0 0 A0A8C0RUE2 A0A8C0RUE2_CANLF MPN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; mitotic spindle assembly [GO:0090307]; protein K63-linked deubiquitination [GO:0070536] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593] AAGDSIEESDDSD;EHGTDFFDKDG;LDRILKDRRKKVIGWYR;NEKEQERRLQQAMISRQVPSESLGP;RGAGGGAG 5 14.3 1.0032 -0.783 0 0 0 0 9.60801 0 0 10.3209 0 0 9.33219 0 12.2012 0 0 A0A8C0RUE6 A0A8C0RUE6_CANLF RHD domain-containing protein NFATC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EAKLDRDLCKPN;GYGGAVDT;PNLEAYRDPSCLSPASSLSSRSCNS;PRPVPPPEVREDSN;PVPPPEVREDSNHSLAP;TDNSLELDGV;TLSLQVASNPI;VEKQSAASCPVLGG 8 10.3 1.0023 -1.1713 0 0 8.54801 10.2342 0 0 0 12.1957 0 9.74802 0 8.82085 8.00972 10.0073 8.53442 A0A8C0RUG4 A0A8C0RUG4_CANLF Nucleoside-diphosphate kinase Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] ATP binding [GO:0005524]; nucleobase-containing compound kinase activity [GO:0019205] DSAHRDYMTCPQSR;EDQGDDQLN;LSFEDQICTPDLVV 3 7.1 1.0019 -0.68208 0 0 0 0 0 0 0 8.99783 0 0 0 6.91121 0 0 0 A0A8C0RUH2 A0A8C0RUH2_CANLF C2 NT-type domain-containing protein EEIG2 Canis lupus familiaris (Dog) (Canis familiaris) TLSHRVPPLSPF 1 3.1 0.9822 -0.24913 0 12.2267 0 0 0 0 0 0 0 0 0 0 0 12.9596 0 A0A8C0RUH8 A0A8C0RUH8_CANLF Sema domain-containing protein SEMA4D Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] ANCRTSSRTSLTPWKMLITQSSHW;EVQLEKFH;TVEQSHTKWVRYNGA 3 5.7 1.003 -1.0092 0 0 0 0 0 0 9.90007 8.31569 0 0 0 0 0 0 0 A0A8C0RUH9 A0A8C0RUH9_CANLF NACHT and WD repeat domain containing 2 NWD2 Canis lupus familiaris (Dog) (Canis familiaris) EDENGAISSLIVMRLADG;ESIEQLFWSLEK;ESTEVFARDSPITVS;LLYGWPLYQFHCW;LQDDGDLREMH;LREMHTILADYFLGV;SFYEYKCESLNIVHKYVL;STEPNEATP;VLSIWDIDIITAMSNIDK 9 7.1 1.0029 -2.1169 0 7.75656 0 12.1501 8.84797 0 0 0 0 0 0 0 9.67927 10.5928 9.48623 A0A8C0RUI5 A0A8C0RUI5_CANLF TBC1 domain family member 32 Canis lupus familiaris (Dog) (Canis familiaris) CTDNCSDSD;ETDENFHNYEFV;LPYPAVYELVGNQ;SLCLLGRLLIYTQGRRL;TDANVKNESLS 5 5 1.0034 -1.0343 0 0 0 0 0 11.7497 0 0 0 3.56218 0 0 0 0 0 A0A8C0RUI7 A0A8C0RUI7_CANLF Apolipoprotein B receptor Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipoprotein particle receptor activity [GO:0030228] DAQEEKAGAEEEEE;DARETEDEEVEA;EEKEAQDALEG;ESGPTVFFASFPAG;GCGAEEGEVPAPESQ;GPSEQEVNREETLRTWEQ;SVIGTVPASVEEVAQAEMAREEKEG;TEGQGSERKVEEG;VAEELGEVAAGRPGKTE 9 11.3 1.0014 -0.69807 0 10.1862 12.8332 0 0 0 10.0272 10.4217 0 0 0 8.99067 0 0 9.90719 A0A8C0RUK1 A0A8C0RUK1_CANLF Spindlin 1 SPIN1 Canis lupus familiaris (Dog) (Canis familiaris) gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] methylated histone binding [GO:0035064] DFHIYVYDLVKT;DKGLLLGIAMMRRGMLP 2 9.8 0.93256 0.096667 0 5.73777 0 0 0 0 0 9.64126 0 0 0 0 0 0 0 A0A8C0RUL0 A0A8C0RUL0_CANLF Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) GNPNAT1 Canis lupus familiaris (Dog) (Canis familiaris) UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802] TLECLPQN 1 4.3 0.99083 -0.2154 11.5189 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RUL1 A0A8C0RUL1_CANLF Ion transport domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ETVNSVASDSWSI;GNTALHALVMIAD;GVSQPDPNRFDRD 3 5.1 0.99348 -0.13259 0 8.99333 0 0 8.18834 0 0 8.6977 0 0 0 0 0 0 0 A0A8C0RUL5 A0A8C0RUL5_CANLF Gap junction protein Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] GVRRGARRRRRP 1 3.9 0.95331 0.05044 0 0 0 0 0 0 6.76315 0 0 0 0 0 0 0 0 A0A8C0RUM0 A0A8C0RUM0_CANLF Centromere protein V Canis lupus familiaris (Dog) (Canis familiaris) ASLPDLGDQR;DLHIFDCKEPR 2 8.7 0.98714 0.035491 0 0 0 0 0 0 0 0 0 10.6074 0 0 0 0 0 A0A8C0RUQ4 A0A8C0RUQ4_CANLF "Polycystin 1, transient receptor potential channel interacting" PKD1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; membrane [GO:0016020] AARTFSNQTLVLDETTTS;AGTQIPIGQLA;AQLSAAARGLAA;CLPFCSGAPLALAP;EAALRRSRRLLVAELQ;EIVAQGKRSDPLS;ETEANGGLVEKEVLA;GAPGNSREPESG;HLASVDMQGLQ;LAASLLFLLLVKA;LAMVDSPAIQHFLVSQ;LVYMLFLLVT;LYRPAWEPQDY;PGEPHPATAERCVRL;RLWMGFSK;SNLFNLSE;VGLHAAVT;VGLVSSVVVYPVYLVILFLFRMSRS;VLEAGTYHVQL;VLEVLRIEPAACIPVQPHTW;VRLQEALCPDPPG 21 6.4 1.0004 -2.8105 0 11.0497 7.80148 0 11.2521 0 6.05845 5.23074 9.1875 8.03205 8.87461 11.0572 11.3538 8.01614 7.2364 A0A8C0RUR3 A0A8C0RUR3_CANLF Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of phosphate metabolic process [GO:0019220]; regulation of protein modification process [GO:0031399] endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] AWVYCPGEDSEEEDDGDSGAAEE;CPGEDSEEEDDGD;DDSEAVNSEPSPSLQ;EQLARDRSRFARRIAQAQEQLGPC;GAAEEEGEAEDSDSGAAEEEG;GGLSDNEDEEYGGEQAATS;IPSTSALMRAWVY;KPGLEREAK;PGEDTEEDDDSEAVNSEPSPS;QDPSEEKSEEGGA;SEEEDEDSDSGAAEEEGEAEDS;VRAWVYCPGEDSEEE 12 24.3 0.93873 0.069675 9.19641 0 3.34227 0 0 0 11.0411 0 10.0161 10.2924 0 14.2718 7.71294 10.0733 6.0706 A0A8C0RUS5 A0A8C0RUS5_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] retinol binding [GO:0019841] IVLRKWWGPSCQ 1 7 0.95333 0.05044 0 0 0 0 0 0 0 5.95112 0 0 0 0 0 0 0 A0A8C0RUT0 A0A8C0RUT0_CANLF THAP domain-containing protein 5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EDDQDKDPSKK;LDIRWGIR 2 18.6 0.98435 0.035491 0 0 0 0 0 0 0 0 0 0 5.06061 0 0 0 0 A0A8C0RUU8 A0A8C0RUU8_CANLF GOLD domain-containing protein TMED3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] AALLLLLLLLRAGRPRGAELT;LLLLLLLL 2 14.3 0.97529 0.047166 0 0 6.57858 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RUV1 A0A8C0RUV1_CANLF NSL1 component of MIS12 kinetochore complex Canis lupus familiaris (Dog) (Canis familiaris) mitotic sister chromatid segregation [GO:0000070] MIS12/MIND type complex [GO:0000444] KRKQYPRKILECVIKTIKAKQEI;PPAVQTGKMAGAPVSGVPSRPRG 2 14.3 0.93604 0.092506 0 0 6.63532 0 0 0 0 10.574 0 0 0 0 0 0 0 A0A8C0RUV5 A0A8C0RUV5_CANLF Secretory carrier-associated membrane protein (Secretory carrier membrane protein) SCAMP3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588] AAGAAENA;VLGIVMLKRI 2 5.6 1.0018 -1.4087 0 6.37709 0 0 0 0 0 0 0 0 0 8.76119 0 0 0 A0A8C0RUV7 A0A8C0RUV7_CANLF Voltage-dependent calcium channel gamma-7 subunit Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816] membrane [GO:0016020] AASAAAEW;KAGASCVSGPAGRPP 2 4.3 0.99183 -0.20932 8.12386 0 8.69822 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RUW0 A0A8C0RUW0_CANLF BOS complex subunit TMEM147 (Transmembrane protein 147) TMEM147 Canis lupus familiaris (Dog) (Canis familiaris) multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein localization to nuclear inner membrane [GO:0036228] endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]; nuclear membrane [GO:0031965] ribosome binding [GO:0043022] LVMSRNAG 1 3.6 1.0042 -1.1044 0 0 0 0 5.07476 0 0 0 0 0 0 0 0 0 0 A0A8C0RUW5 A0A8C0RUW5_CANLF Protein kinase domain-containing protein TEX14 Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ACCFCDEDES;CFCDEDES;DEIEHLKQQ;DIRYILKNDLKDF;EACCFCDED;EACCFCDEDE;EACCFCDEDESSSE;FGKFYLMGGAQLAYLGSLPVIGE;KSLDSFLTSSE;PKVQRYELHPD;QEECRSLWASSREFAN;QEHSSKLRHPHLLQ;QEILTDNIPWNG;RSQFPVLHMEVIV;SSEAGTELSFEDWDWQ;SSRCFDGS;TVKELNLPTHPHC;YELHPDVNVYLGL 18 12.4 0.99663 -4.8693 0 0 0 8.27244 8.38016 11.2113 10.6746 9.38493 0 0 9.09735 0 9.07047 8.04489 0 A0A8C0RUX8 A0A8C0RUX8_CANLF Tubby-like protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] IGRVAPDTFTMDFRFPLC;TFTMDFRFPLC 2 3.5 0.99439 -0.15477 0 0 14.7397 8.75358 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RUY4 A0A8C0RUY4_CANLF RCAN family member 3 RCAN3 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722] nucleic acid binding [GO:0003676] FSVVPKARN;GPGEKYELH;SPRGVQPPGAGGGGRGR 3 6.3 0.99399 -0.11949 0 10.7685 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RUY5 A0A8C0RUY5_CANLF DDHD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phospholipase activity [GO:0004620] AGHEPEMEELV;DIMTGWNPVRLYEQLLQKEEELPDE;EDDDDDDD;GEEEEDDDDDDD;GGGGGGGG;MYKHEHDSNAKPN;PSFLHPAK;SSGEEEEDDDDDDDG 8 9.6 1.0035 -1.6338 0 8.90454 0 0 0 0 4.25633 0 0 0 0 0 0 0 8.73644 A0A8C0RUZ4 A0A8C0RUZ4_CANLF NHERF family PDZ scaffold protein 2 NHERF2 Canis lupus familiaris (Dog) (Canis familiaris) GLRAQDRLIEVNGQN;QDRLIEVNGQN 2 6.6 0.93701 0.089393 0 0 0 0 0 0 0 0 9.73122 0 0 0 0 11.238 0 A0A8C0RV37 A0A8C0RV37_CANLF Surfeit locus protein 4 SURF4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] MFAGVPTMRESSP;WGEQRDYIDTTWGCGYALA 2 11.9 0.98911 -0.21481 0 0 0 0 0 0 0 4.54689 0 0 0 0 9.4283 0 0 A0A8C0RV38 A0A8C0RV38_CANLF UBR-type domain-containing protein UBR4 Canis lupus familiaris (Dog) (Canis familiaris) calmodulin binding [GO:0005516]; zinc ion binding [GO:0008270] ADTTPGWEVAVRPL;ALIRVLRPRNKRRH;APGASATGADTT;DDDDDDDADDKM;EEEDSQAEDSDEDSLCNK;FICGSKEKYRQLRDLHTLDSHV;FTESKLPPMETEG;GVPLVVMVKPDTF;HTLRWSSRLRI;IAELGMDKKD;LCNKLCTFTITQKEF;LVALLEDDSGMELLVN;LVNHFWKLHAS;MSSDASASTDSNTYYEDDFS;QAARQAACTIV;QDSNSRRVTTPL;RHNTYLQECTGQREPTYQLNIH;RMTASPPKDSDQLDVIQENRQL;SQEQSEVDHGDFEMVSESMVL;STMVMTGMRIQI;TDEEEDEEE;TELAIVTADFVKIY;TPMGDKDDDDDDDADDKMQSSG;TVALPPGG;TVKPYCNEIHA;VLSRLLLIWQHK;VSGRSSAYG;YYEDDFSSTEEDSSQDDD 28 7.3 1.0001 -2.8335 4.40334 9.41806 7.06609 11.9432 14.7555 10.086 10.5836 11.5331 9.13062 3.25675 10.1845 11.8147 0 9.53167 8.94442 A0A8C0RV41 A0A8C0RV41_CANLF Ribosomal protein S6 kinase C1 RPS6KC1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein kinase activity [GO:0004672] EVEDSCDSDAIERM;LLFTDQTEDLAKEEL;PECSTEGESSPTRREAV 3 5 0.98582 0.046227 0 8.65155 0 3.4994 0 0 0 0 0 0 0 0 4.70752 0 0 A0A8C0RV49 A0A8C0RV49_CANLF Nonsense-mediated mRNA decay factor SMG8 SMG8 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" EDEICVVGIFG;SQDPAHPDKPKKHS 2 2.8 0.99415 -0.11862 0 0 0 0 0 0 11.5849 0 0 11.6509 0 0 5.19342 0 0 A0A8C0RV56 A0A8C0RV56_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DAQKEELSRELMQENQ 1 3.3 0.98252 -0.25039 0 0 9.65587 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RV62 A0A8C0RV62_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] CDADGIAQTCNAE;DNPPRFPRRSYQYNV;EEGPAAELPSRCRPLNPP;GQTDARAGSGERVPGCAGQDP;ILACVLTLLVLILLIVTMRRRK;RKKKKKMKL;RLLHLSGRCGSPR;TLLVLILLIVTMRRRK;TRRNGFRRQEQSVYYLPI;VLTLLVLILLIVTMRRRKK 10 10.2 0.94934 0.04991 0 0 0 0 0 8.12897 0 0 0 0 0 0 0 0 0 A0A8C0RVA6 A0A8C0RVA6_CANLF Glutamate-rich WD repeat-containing protein 1 GRWD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAPSKACMLTTTS;EAGDTETDPGLADLPQQLLF;PSEGSDDEEEEDEEDEEDR 3 11.8 0.93831 0.10408 6.30511 0 0 0 0 0 8.48341 0 0 0 0 0 0 0 0 A0A8C0RVC4 A0A8C0RVC4_CANLF Mab-21-like HhH/H2TH-like domain-containing protein ITPRIPL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALVCLYHALRGSG 1 2.4 0.99147 -0.20622 0 0 0 0 0 0 0 0 0 0 0 0 9.26833 0 9.43035 A0A8C0RVC6 A0A8C0RVC6_CANLF Proteasome 20S subunit alpha 1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] "nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" EDAEMCHP;NFMHQECLDFRFVF;RPQRRAQPAQPDDEPAEKAD 3 13.4 0.98784 -0.4019 3.4518 2.54804 0 0 8.49169 0 0 0 0 0 0 0 9.07181 0 0 A0A8C0RVD4 A0A8C0RVD4_CANLF DNA polymerase subunit gamma-1 (Mitochondrial DNA polymerase catalytic subunit) POLG Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] gamma DNA polymerase complex [GO:0005760] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GVACPYRAIES;NWVVQSSAVDYLHLM;PKMEDGTLQAGPGGASGP;PPPRPLSWAWVEGW;TITRRAVEPTWLT;VFDVEVCLAEG;WDGFPLHYSERHGWGY;WEMKKSLMDLANDACQL 8 9.9 1.0026 -0.77128 0 0 0 11.8429 0 9.5254 7.64306 0 0 0 0 0 0 11.902 0 A0A8C0RVE8 A0A8C0RVE8_CANLF DH domain-containing protein ARHGEF10L Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] APADGSALEHSEEDGSIYEMA;DESHVATEPSATVH;EAFEFDDSDDDE;EDAPLIHLDSAP;EGACATGHII;EGAGGQVEIFSLNRP;ELTRKKGILLQYRL;GPRAEEDKPDGQAHE;IVLLPVPRLE;NLLYEDVHRDGGPREA;SEEEDMGLLEVSV 11 11.8 1.0026 -1.3744 10.8836 10.1126 0 0 8.44079 0 6.53804 0 10.4107 9.31465 0 11.5995 10.5416 0 8.47581 A0A8C0RVF4 A0A8C0RVF4_CANLF IKAROS family zinc finger 3 IKZF3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] PEPMGNAEEPEIP;VDSAEGPTNEDEDLG 2 5.5 0.99141 -0.51333 0 0 0 0 0 0 11.719 0 0 0 0 0 0 0 0 A0A8C0RVH0 A0A8C0RVH0_CANLF Solute carrier family 35 member D3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGKGAGGF;RYQFSFLTLVQCLTS 2 5.5 1.0049 -1.0505 0 0 6.84034 0 0 8.55593 0 0 0 8.76002 0 0 0 0 0 A0A8C0RVH3 A0A8C0RVH3_CANLF Clusterin CLUL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; nucleus [GO:0005634] misfolded protein binding [GO:0051787] ESNCMRFHTTCQPSWSSM 1 4.3 0.97694 0.048313 0 0 0 0 0 0 0 0 6.63391 0 0 0 0 0 0 A0A8C0RVK9 A0A8C0RVK9_CANLF "Zyg-11 family member A, cell cycle regulator" ZYG11A Canis lupus familiaris (Dog) (Canis familiaris) IVPPDAQKDALGWCVVQEEASPY;TDGAVELF;VEEEGLQLLCDI;VLGLWNNIAE 4 7 1.005 -1.0502 0 0 0 9.80319 0 9.6097 0 0 0 0 0 0 0 0 0 A0A8C0RVN6 A0A8C0RVN6_CANLF Multidrug and toxin extrusion protein Canis lupus familiaris (Dog) (Canis familiaris) xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] membrane [GO:0016020] antiporter activity [GO:0015297]; xenobiotic transmembrane transporter activity [GO:0042910] VGVILQRGTLV 1 2 0.98517 0.035491 0 0 0 0 0 0 0 11.826 0 0 0 0 0 0 0 A0A8C0RVN8 A0A8C0RVN8_CANLF Sterile alpha motif domain containing 11 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ELTPSFSASD;LTEEHLLTTMGLKLGPA;RPSLLHGQ;SSAPLLALPPQGPPGPGPPT 4 6.4 1.0011 -0.9456 0 0 0 0 0 0 0 0 0 0 0 0 0 12.516 6.69988 A0A8C0RVQ9 A0A8C0RVQ9_CANLF NOC2 like nucleolar associated transcriptional repressor NOC2L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEEDGSCSSQEVS;DLWRLAQGP;EDRVEFKDLFDLHSD;EEDEEDEEDGSCSS;EEEEDEEDEEDGSCSS;EEEEEEEDEEDEEDGSCSSQ;EEEEEEEEEDEEDEEDGSCSSQ;INFMVILKLSKV;PGAWQRVKEEEEEEEEEDE;SPGAWQRVKEEEEEEEEEDEEDEED;TPLTKYYN;VPTARFYPL 12 11.5 1.0027 -1.0094 0 0 12.4463 0 7.13504 11.178 0 0 9.96 0 0 0 9.57416 8.76042 9.02156 A0A8C0RVR5 A0A8C0RVR5_CANLF BHLH domain-containing protein OLIG3 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] PVHPILGG;SLSRAGAK 2 5.9 1.0023 -1.3703 10.451 0 0 0 0 4.36324 0 0 0 0 0 0 0 0 9.61787 A0A8C0RVS2 A0A8C0RVS2_CANLF Multidrug resistance-associated protein 1 (EC 7.6.2.2) (EC 7.6.2.3) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (Leukotriene C(4) transporter) ABCC1 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; glutathione transmembrane transporter activity [GO:0034634] ALLRKTKILV;AWELAFKDKVLAIRQ;DDGGKVVHQEEE;DEEVWTSLEL;ETEKEAPWQIQ;ETLLGVSVI;GACIIILLAT;IVMTGGKISEMGSYQELLARDGA;LSRVTFWWI;NEEAEVLIVK;RENLDLVLKHINITINGG;SEMETNIVAVERLKEY;VAIKGSVA;YCDSDIYLFDDPLS 14 11.4 0.99694 -3.6452 6.16842 7.28623 13.5145 0 11.4577 0 10.7118 12.5258 0 0 11.0421 7.8515 0 13.4712 8.6531 A0A8C0RVS6 A0A8C0RVS6_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DSEQNSNVPNV;FPDGTTQLQLQRSPEG;GVDHAEGA;GVPPERPAGDVDWDSG;HRHEEAKHLLQRARMKARTRPL;LSEPGEPADTPL;NGHLPRPWSCSL;PPSAAPSD;QNGHTSDSSSGESSSGRWPR;RGPPRSEPDLGRYG;SSSSLASTLG;VTPGQPGGP;WNGRSPWPPEAV 13 13.9 0.99286 -0.16543 0 0 0 0 0 0 0 0 0 10.8694 0 0 0 0 0 A0A8C0RVW2 A0A8C0RVW2_CANLF Major facilitator superfamily (MFS) profile domain-containing protein MFSD14B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LTELEPELNS;PPEPEDKTASVPPAGAMPEKRPGA;STVLLICIT 3 9.1 1.0019 -0.6844 0 10.1471 0 0 9.30684 0 0 0 0 0 4.97347 0 0 0 0 A0A8C0RVW8 A0A8C0RVW8_CANLF "Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1" GBGT1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; lipid glycosylation [GO:0030259] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle [GO:0031982] globoside alpha-N-acetylgalactosaminyltransferase activity [GO:0047277]; metal ion binding [GO:0046872] VGKWYCDCE 1 2.6 0.98419 -0.24409 0 0 0 0 0 9.8826 0 0 0 0 0 0 0 0 10.6645 A0A8C0RVY5 A0A8C0RVY5_CANLF FA complementation group M FANCM Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclease activity [GO:0004518] EAEYVSSDENDESENEQD;EDSPDILPYSHERRV;ESDEECAEIFKQTH;IELRSEDSPD;IPEQDETYLEDSFCVDE;IVPSGSSLQ;LEAFASSLIQRNIL;LSLSEWRVWQ;LVAVYEAEQQLRVENGGFCTS;NLTKYQIILARDQ;QKDNKNENLVSSNH;RMVVERRSQSEMLNS;SYLKMEDV;VSSDENDESENEQDSSL;YHGYELLQQMGMRSLYFFLC 15 10.3 1.0032 -2.4494 0 11.922 11.6405 10.1803 0 0 9.95124 0 10.0479 11.589 8.92899 7.26866 11.2798 11.0432 0 A0A8C0RW04 A0A8C0RW04_CANLF very-long-chain 3-oxoacyl-CoA synthase (EC 2.3.1.199) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633]; intracellular signal transduction [GO:0035556] membrane [GO:0016020] fatty acid elongase activity [GO:0009922] GLLQKEKMA;KKKKLKQFQKSY;LDTIFFVLRK;LGLLQKEKMAIE;LRKHRCRFK;QEILKVPLALQ;VIEDIKGKW;VTSLGPKL 8 9.8 1.0031 -2.4296 11.6705 5.47063 9.93965 7.63844 7.25993 10.9117 0 0 11.2014 10.9336 0 10.8588 0 0 9.76165 A0A8C0RW19 A0A8C0RW19_CANLF Structural maintenance of chromosomes flexible hinge domain containing 1 EMILIN2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome organization [GO:0051276]; double-strand break repair [GO:0006302] chromosome [GO:0005694] ATP binding [GO:0005524] AAGGGGGG;DDSLNLLKSLNDTMHRKFQETERS;DEDDDDDCFI;DERFLHHLI;DLHLTITD;DPRKRPHTGQRPV;DRREKESELGDRVL;FSFGLMDP;GGGGGGGG;GVGGKQAV;LDSSHLKT;LFTNDKFQVST;LHTCGGPG;LKNSCEYKLIGLQQQCD;LQEKKIQVLEEKVLRLTRT;LSVTWPEGDELLPN;LVLSKEDFEKKE;NSGNRPPANAETFSCNKI;SALVYRVN;SVLEGSESFIQ;TRQLAHIYHYYIH;VLLIDWPELKE 22 8.4 0.99716 -6.7093 11.0021 6.40473 12.6165 0 9.46326 0 0 8.10171 15.5073 10.2937 10.3183 10.2052 12.0717 9.39579 0 A0A8C0RW25 A0A8C0RW25_CANLF GrpE protein homolog GRPEL1 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] mitochondrial matrix [GO:0005759] adenyl-nucleotide exchange factor activity [GO:0000774]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] EPGTVALV 1 3.7 0.98992 -0.26592 0 0 0 6.14256 6.39635 0 0 0 0 0 0 0 5.31125 0 9.11184 A0A8C0RW31 A0A8C0RW31_CANLF "Afadin, adherens junction formation factor" Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; signal transduction [GO:0007165] cell-cell junction [GO:0005911] ADFAVAEALEKYGLE;ARQEDERRRQEEERAKRDAEEKRR;LVHCLQSELNNYM;LVSRESWAES;LVVQLNWNKDDREGRFVLKNENDA;MGLSIVAAKVQEQAPRPAVHP;PFQGDDIENSRLA;SRIVQATTLLTMDKYAPDDI;TSKSTTRL;VAVAENTADEL;VEGQRISETTMLQSGMK;VLYMACRYVL 12 9.9 1.0021 -1.2714 0 0 8.4121 9.9857 11.6066 0 8.60036 6.77992 0 0 0 0 9.38487 11.1157 6.09081 A0A8C0RW36 A0A8C0RW36_CANLF Vimentin Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109] axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886] structural constituent of cytoskeleton [GO:0005200] EMRELRRQVDQLTNDK;ERKVESLQEEIAFL;ESLQEEIAFL 3 7 0.96275 0.049233 0 0 0 0 0 5.86034 0 0 0 0 0 0 0 0 0 A0A8C0RW42 A0A8C0RW42_CANLF Family with sequence similarity 187 member B FAM187B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGPVLKGLKLTLLVGIVLGLLGL;AGPVLKGLKLTLLVGIVLGLLGLL;KGLKLTLLVGIVLGLLGL;KGLKLTLLVGIVLGLLGLLL;PVLKGLKLTLLVGIVLGLLGLLL;RQQGAREASKGKAGP;VLKGLKLTLLVGIVLGLLGLLL;VLKGLKLTLLVGIVLGLLGLLLK;YHCQDENGIQ 9 13.2 0.99182 -0.20896 0 4.06048 0 4.74308 5.67093 0 11.7053 8.61206 0 0 3.96523 0 7.91043 0 4.2121 A0A8C0RW53 A0A8C0RW53_CANLF Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] actin binding [GO:0003779]; calmodulin binding [GO:0005516]; structural molecule activity [GO:0005198] AAVDSDRSPRPTSA;DITRYYLCLQLRQ;HQQQKEEGEGVTNSGQQETQ;LDLHSLSSAETQTWL;QDIVSGRLPCSFATLALLGSY;TEDITRYYLCLQLRQD;TETKTITYE;VPWNFTFNVKFYP 8 11.7 0.95074 0.057527 0 0 0 0 0 0 0 10.1957 0 0 0 0 0 0 0 A0A8C0RW54 A0A8C0RW54_CANLF SPARC related modular calcium binding 2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; heparin binding [GO:0008201] AYRGNCRDVSR;EGTGKTDDASAPALE;ERGAAAAAAAAAAAAAAARGWGW;KSKPKKCVKKFV;RAVGEPQGRSCAQGVG;VLPDSTFT 6 12.4 1.0024 -1.3907 0 0 11.0031 0 0 0 0 6.00888 11.3051 0 2.21863 0 0 0 0 A0A8C0RW65 A0A8C0RW65_CANLF Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK Canis lupus familiaris (Dog) (Canis familiaris) AMP salvage [GO:0044209]; purine ribonucleoside salvage [GO:0006166] nucleus [GO:0005634] adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524] HLDMDKNWTL;KHKELFDE;MTSIRDHFLFFFFFFF;QNSIKVAQWMIQQPYKA;VLDQDQKEIVDTN 5 16.7 1.0021 -1.2956 10.5261 0 0 0 0 0 0 10.5314 0 6.98812 0 0 0 0 0 A0A8C0RW76 A0A8C0RW76_CANLF C3H1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] AEQQFHPEIYKSTKCNDM;APPVVTAA;DEHDSGDP;GQLCGGDGVPDLQ;PDVYCSKYDEASGVCPDGDE 5 8.9 1.0019 -1.206 0 8.84978 0 0 0 0 8.28582 0 8.27794 0 0 9.26648 0 9.37602 9.1609 A0A8C0RW85 A0A8C0RW85_CANLF Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] lysosomal membrane [GO:0005765] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] CDVPPNSRFDCAPD;FPDFTSPTALDW;IVDPAISSSSPPG;PAPTSSSAHVHHPQQGA;TLWNRDIAPSPNVNLY 5 7.7 0.96519 0.048352 0 0 9.58099 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RWA6 A0A8C0RWA6_CANLF Protein Wnt WNT4 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] EVMDSVRRGAQLAIE;GTGRTRGCLKAQRNG;GVAFAVTRA 3 9.2 0.95229 0.053899 0 0 8.42408 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RWB7 A0A8C0RWB7_CANLF DMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] PERRSRAKRGELG 1 2 0.98331 -0.25176 0 0 0 0 0 0 0 7.633 0 0 0 0 0 0 0 A0A8C0RWD3 A0A8C0RWD3_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 6 ADAMTS6 Canis lupus familiaris (Dog) (Canis familiaris) aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; extracellular matrix organization [GO:0030198]; kidney development [GO:0001822]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DSSLGNVVNII;GHNFGMNH;KPYTGGGV;VLITRYDICTYK 4 3.5 0.98633 -0.45444 0 0 0 0 5.67008 0 11.2211 0 0 0 9.19525 8.28151 0 0 0 A0A8C0RWD9 A0A8C0RWD9_CANLF Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) NMNAT2 Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515] SVLEHHRDL 1 3.2 0.99181 -0.20867 0 0 0 0 0 0 8.1812 0 0 0 0 0 0 0 0 A0A8C0RWE2 A0A8C0RWE2_CANLF RNA binding motif protein 18 RBM18 Canis lupus familiaris (Dog) (Canis familiaris) QGPARASTPSRGHSPAVAPGA 1 8.4 0.95813 0.051087 0 0 0 0 0 0 6.53667 0 0 0 0 0 0 0 0 A0A8C0RWE6 A0A8C0RWE6_CANLF Phosphatidylinositol transfer protein alpha isoform PITPNA Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409] cytoplasm [GO:0005737]; nucleus [GO:0005634] phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] LQNKVENFIHKQE;LVNEPYEKDGEKGQYTHKIYHL;TVITNEYMKEDFLI;VSVDEYQVGQ 4 21.9 1.0025 -1.0122 0 0 0 0 0 0 0 11.5517 8.96711 0 0 10.6133 0 0 0 A0A8C0RWF0 A0A8C0RWF0_CANLF EamA domain-containing protein SLC35F4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IGGEGEADFL;SSAPILELQSRGSSGVC;VHLRSRSRANGTV 3 7.8 0.99509 -0.082348 10.6609 0 0 10.8525 0 10.3358 0 0 0 8.24441 0 11.0124 0 0 0 A0A8C0RWF4 A0A8C0RWF4_CANLF Modulator of non-genomic activity of estrogen receptor Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] AGPMPPAG;APSGTPPPAIPPDETF;APVQYEGPGVEVL;ECYSRLPSLGA;EEEEEEEEEEEEEDFEEEEEEEEY;EEEEEEEEEEEEEEDFEEEEEEEEY;EEEEEEEEEEEEEEEEEEED;EEFEEEEGELEEEEEEEDEEEEEEL;EFEEEEGELEEEEEEEDEEEEEEL;EYFEEEEEEEEE;FEEEEEEEEYFEEEEEEEEEFEEEF;LEEEEEEEDEEEEEELDEG;PALEEDLTVI;RVPRPAFVHYDK;SSDEEEEEEEEEEE;TVININSSDEEEEEEEEEEEEEEEE;VININSSDEEEEEEEEEE;VPGLVSVPPRLIPGPENHRAGSNED;WEQELHSLLAS;YFEEEEEEEEEFEEEFEEEEGEL 20 20.5 0.95264 0.04941 0 0 0 0 0 0 4.37337 0 0 0 0 0 0 0 0 A0A8C0RWF9 A0A8C0RWF9_CANLF Solute carrier family 43 member 2 SLC43A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] RRQLERQLQ;VGSSMRSAKEQAALQEGHKLCL 2 7.3 1.0027 -0.75624 0 0 0 0 0 0 0 0 0 0 0 0 6.56669 7.34873 0 A0A8C0RWG3 A0A8C0RWG3_CANLF GRAM domain-containing protein GRAMD1A Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] IFRWETTISI;PEAERLIVDYSC;VGGWGHWS;VGGWGHWSPSLP 4 17.3 1.0026 -0.7736 0 0 0 0 0 14.8739 0 0 0 0 0 0 0 0 0 A0A8C0RWI3 A0A8C0RWI3_CANLF Laminin subunit gamma 1 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576] DIAVISDSYFPRYFIA;EDLDHLIDQKLKDYED;LVSHEACSPCHCS;QCEENYFYNRSWP;QDMMMAGMASQAAQEA;TGSSSDCQPCPCPG;VLCTCNGHSETCDPETGVCD 7 6.7 0.99898 -0.60978 0 0 8.03821 6.4518 0 0 0 11.2273 0 0 6.58225 0 0 0 8.8463 A0A8C0RWI4 A0A8C0RWI4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;TMPDLTLYY 4 3.4 0.9881 -0.22451 0 0 0 0 0 0 0 0 0 0 0 10.5891 0 0 0 A0A8C0RWI8 A0A8C0RWI8_CANLF ABO glycosyltransferase Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758]; metal ion binding [GO:0046872] IRRKKLKVLKKNYQ;KIIRRKKLKVLKKN;QEMIFSKIIRRKKLKVLKKNYQLK;QEVDYLVCSDVDMRFS;RRKKLKVLKKN 5 12.3 0.99364 -0.073818 7.71747 0 0 0 0 4.49902 7.93487 0 0 0 0 0 0 0 0 A0A8C0RWJ9 A0A8C0RWJ9_CANLF Forkhead box protein N3 FOXN3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DDTPPSPAHSDMPYDA;GVIQNGARALSRGLFPGVR;VMPPSKKPESSGI;VQDLDDDTPPSPAHSDMPYDA 4 11.4 0 1.5831 9.44929 12.5588 12.5666 10.1486 0 9.69284 0 12.613 12.6087 9.48301 9.49354 0 11.4126 7.749 8.72223 A0A8C0RWL4 A0A8C0RWL4_CANLF 60S ribosomal protein L21 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] PWQNWKGLQCYSACCWHCC 1 22.9 0.95237 0.04941 0 0 0 5.6316 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RWL8 A0A8C0RWL8_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVGQNTDIQQIATS;RRRRGNLPKESVQILRDWLYEH 2 14.3 0.9895 -0.53065 0 7.34952 0 0 0 0 9.84674 0 0 0 0 0 0 0 0 A0A8C0RWM2 A0A8C0RWM2_CANLF Telomerase-binding protein EST1A (EC 3.1.-.-) SMG6 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" "chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleolus [GO:0005730]" endonuclease activity [GO:0004519]; manganese ion binding [GO:0030145] DLILSCCLHYC;EDVVIEDFEEDS;LARKIAEQQRRQE;LARLLESRKYILVVPLIVI;LNGDRVRAAKGEKG;LVVPLIVINELDGL;QLGNNDDLILSCCLHYC;RLLRVADNQELQL;RNRLLELLDEGSD;SEDITGQLGNNDD 10 8.7 1.0006 -0.63482 0 0 0 0 5.54668 12.964 0 9.92775 0 0 0 0 7.14496 5.74819 10.0408 A0A8C0RWN4 A0A8C0RWN4_CANLF Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349] FIGTPYWMAPE;TEIGAGSQQLDSIHVTQLERD 2 3.8 0.97762 0.047802 0 0 0 0 0 0 8.51527 0 0 0 0 0 0 0 0 A0A8C0RWN5 A0A8C0RWN5_CANLF "Nucleoside-triphosphatase, cancer-related" Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ribonucleoside triphosphate phosphatase activity [GO:0017111] AGSSSGPGQ;GVPVDGFYTEEVRQGGRRI;WNLPPLKFIRVF 3 14.4 1.0025 -1.3586 0 0 0 0 8.64014 0 0 13.135 0 0 0 0 0 0 0 A0A8C0RWP2 A0A8C0RWP2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GAGGGGGG;PAAPRRRRRRRRRRRG;SGHSPGGP 3 4.5 1.0037 -1.0552 0 0 0 0 0 0 0 0 0 9.41882 5.67928 0 0 0 0 A0A8C0RWP5 A0A8C0RWP5_CANLF "RB binding protein 6, ubiquitin ligase" RBBP6 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] nucleic acid binding [GO:0003676]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CCGNSYCDECI;EEEKKKSKLDEFTNDFAKELM;EKERYREWERKYREWYEKYYKIGYA;EQRRLKEE;ERRRSFSRSKSPYS;ETDEAAFEPDYNESDS;KLESTSSK;LVSPPQQIRRGERSCYR;PIGGVKSTSKTYVISRTE;QDSKKKKKKKEKKKHKKHKKH;RDPFEKERYREWERKYREWYEKYYK;RSVDFRDPFEK;SLLGQSLLH;SVDFRDPFEKERYREWERKYREWYE;TDYDDREYSSSKRRDE;VIPCCGNSYCDEC;YVISRTEPVMGTS 17 11.1 0.95935 0.049233 0 0 7.02192 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RWR4 A0A8C0RWR4_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FLSPAVFVAYARNS;WVPLSVWGEG 2 6.3 0.9921 -0.55034 0 0 0 2.87902 0 0 8.78195 0 0 0 7.29627 0 0 0 3.18591 A0A8C0RWS1 A0A8C0RWS1_CANLF DISC1 scaffold protein DISC1 Canis lupus familiaris (Dog) (Canis familiaris) ADLEACQLLIQ;DAAGGGTW;FTLELSAG;GFTLELSAGSGH;IGFLYPAVAAPFQA;PPAASFRRRR;QARMSVLEAKDQQLRREIEEQEQLL;STLRKKVNDI;TPAGSQDAFTSSFSFIRLSL 9 13.8 1.0032 -2.3324 9.52748 0 9.45004 0 0 9.35848 9.93796 0 0 9.58523 10.6626 9.70314 9.40378 0 11.4227 A0A8C0RWT7 A0A8C0RWT7_CANLF IQ motif containing GTPase activating protein 1 IQGAP1 Canis lupus familiaris (Dog) (Canis familiaris) EQLWLANEGLIT;IQSLTRMHQ;NLNDPNKEALAKTEVSLTLTN;PMIVVRKFVHLLDQSD;TLINAEDPP;WVKHWVKGGYYYYHNLET 6 7.7 1.0025 -1.1666 6.25827 0 0 0 0 8.03111 4.69421 0 8.82798 8.47946 0 0 8.82607 10.3041 0 A0A8C0RWW4 A0A8C0RWW4_CANLF S100 calcium binding protein A5 S100A5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914] AIVCTFQEYS;LSCVAMMCNEFFEGFPDK;NEVDFQEYCVF 3 21.9 0.98625 -0.45446 0 0 0 0 0 0 0 0 8.50124 10.8941 0 0 0 0 0 A0A8C0RWW8 A0A8C0RWW8_CANLF Choline transporter-like protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] organic cation transmembrane transporter activity [GO:0015101] AIVSTVITA;AVVLSLIFVFRKRIKLTTELFQVI;EDSHIKEAHGLIFS;FRCCFCCFWCLDKCLRQLTQNAYT;GAPAPASAERTPRPREWRPQL;GVLWWLYYDYTHDLSIE;KHGAWSRCMFRCCFCCFWCLD;LIFVFRKRI 8 17.7 1.0022 -1.4416 0 9.1752 0 0 6.60514 9.82042 0 0 0 0 8.972 9.20504 0 0 8.63883 A0A8C0RWX2 A0A8C0RWX2_CANLF Integrin subunit alpha 7 ITGA7 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] VILLAVLAGLLVLALLVL;VLAGLLVLALLVLLMWKMG 2 2.1 0.94985 0.049568 0 0 0 0 0 5.76877 0 0 0 0 0 0 0 0 0 A0A8C0RWY2 A0A8C0RWY2_CANLF tRNA-splicing endonuclease subunit Sen15 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" nucleus [GO:0005634] nucleic acid binding [GO:0003676] GGGGGGGA;GGGGGGGG;IVESDSTIVYYK;PGGGGGGG 4 12.8 0.95329 0.05044 0 0 0 0 0 0 8.22183 9.20146 0 0 0 0 0 0 0 A0A8C0RX07 A0A8C0RX07_CANLF CD63 molecule CD63 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886] GAAAAAAAGERSAASGSPGEA;IYSEGCVEK;PGGGGAGA;RGWGRLPSTSRRAA;VTREAGGPG 5 10.5 1.0032 -1.4942 0 0 10.095 0 6.7987 0 0 0 0 0 0 10.6896 0 0 0 A0A8C0RX12 A0A8C0RX12_CANLF PiggyBac transposable element-derived protein domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) non-replicative DNA transposition [GO:0098038] transposase activity [GO:0004803] EIYCCGLL;FEELEKQEIYCCGL;LGAQPAVARRQE;RQEHPPQQRPPR;VMSQARFE 5 5.5 1.0029 -1.5246 0 0 11.0103 0 0 0 0 9.13324 0 0 0 7.47151 0 9.93381 0 A0A8C0RX44 A0A8C0RX44_CANLF Mitochondrial cardiolipin hydrolase (Choline phosphatase 6) (Mitochondrial phospholipase) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) PLD6 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; meiotic cell cycle [GO:0051321]; mitochondrial fusion [GO:0008053]; P granule organization [GO:0030719]; piRNA processing [GO:0034587]; positive regulation of mitochondrial fusion [GO:0010636]; spermatid development [GO:0007286] mitochondrial outer membrane [GO:0005741] cardiolipin hydrolase activity [GO:0035755]; endonuclease activity [GO:0004519]; protein homodimerization activity [GO:0042803] NVLIMEDEEYVRLFLEE 1 7.5 0.97914 0.046227 0 0 0 0 0 0 0 0 0 0 8.34736 0 0 0 0 A0A8C0RX69 A0A8C0RX69_CANLF Nudix hydrolase domain-containing protein NUDT14 Canis lupus familiaris (Dog) (Canis familiaris) LGPALLPELVFPPS;YELCAGLV 2 4.4 1.0046 -1.0436 0 0 0 0 0 0 6.55943 0 0 0 0 0 0 0 8.97645 A0A8C0RX80 A0A8C0RX80_CANLF Coiled-coil domain containing 3 Canis lupus familiaris (Dog) (Canis familiaris) WGSMLEVP 1 2.9 0.9844 -0.24353 0 12.1348 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RX95 A0A8C0RX95_CANLF Large ribosomal subunit protein uL15/eL18 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] IYLRLLVKLYRFLA 1 10.9 0.93935 0.060769 4.64881 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXB5 A0A8C0RXB5_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] CALKCNDT;DLLTYLRK;EFFSVNAS;ELKYKMLEFQER;GVINEGFEGKFDFESFSEFSGF;ISVIQCTVLNSCLKSCVTN;IVTHVKLLV;LYWTTLYSVESTR;RMFVLPSGKYYKQ;SNTEEITPPSI;SRPTNHSNGKKQCFCGVTEF;THVKLLVNDMVVD;VILGSYAQP 13 7 0.97738 0.04742 7.88777 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXC1 A0A8C0RXC1_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] ACSRLSRAHLQTRKPRRGGGGV;EALKASNGDI;EQCCSADEG;NWRFEQEVEEW;PSAEIIVL 5 3.9 1.0039 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 6.79701 0 0 A0A8C0RXD9 A0A8C0RXD9_CANLF Cadherin-20 CDH20 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AIQRLDREERAQYTLRAQAL;CDDDGQVLSCSPE;DGSVAGSLSSLQSA;DLDEGINAEMKYTIVDGDGADA;IVDGDGADAFDI;LVLVLLILSLRRHR;LVLVLLILSLRRHRKQPYI;PYVATVPEMSPVGTSVIQ;VLEEYTGTDPLY 9 15.1 0.99155 -0.0026034 7.1153 12.303 0 0 0 0 7.78686 0 9.89418 0 0 0 0 7.53947 0 A0A8C0RXE0 A0A8C0RXE0_CANLF Sorting nexin 29 SNX29 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] AEVVPNLWNVDGEVTVT;ANKRRPMRFS;DDEEEEQN;DEDVDDNEDDAYGNM;SSSWKIDSLSLNGEFGYQKL;VYQVYIRIKDDEWNVYRRYTEFRSL 6 10.7 1.003 -1.5296 7.20926 0 0 0 5.37093 0 0 0 10.5176 0 3.75307 7.69105 0 0 0 A0A8C0RXE9 A0A8C0RXE9_CANLF Beta/gamma crystallin 'Greek key' domain-containing protein CRYBG2 Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] ALLSWARTW;EQVELTDALEDTQGLEK;EVLVTGPG;FEDDQTSLP;FGEKNFEGDQ;QPPYTAPEVP 6 3.3 1.0046 -0.80421 0 0 0 0 0 0 7.49769 0 0 0 0 0 0 0 0 A0A8C0RXF3 A0A8C0RXF3_CANLF Dehydrogenase/reductase SDR family member 7B (Short-chain dehydrogenase/reductase family 32C member 1) DHRS7B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" GIFSLFKLLQR;IPFRSAYAASKHATQAFFDCLRAEM;LLCQVRKESQKYTRRKSLLKVRI 3 15.7 0.91776 0.11728 0 6.64587 0 0 5.56718 0 0 0 0 0 0 0 0 0 7.52638 A0A8C0RXF6 A0A8C0RXF6_CANLF SH2 domain containing 5 Canis lupus familiaris (Dog) (Canis familiaris) AGGRRASD;EVQILHLLLC;KKAIHSKVIRSG;SQNVHALVSF;VGSFPVDDLDTQEGVW 5 13.1 0.95524 0.05044 0 0 0 0 4.4907 0 0 0 0 0 0 0 0 0 0 A0A8C0RXG8 A0A8C0RXG8_CANLF Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.6.1.68) (Phospholipid phosphatase 6) Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637] hydrolase activity [GO:0016787] GGGGGGGG;IVDYCWLSPHNARVLFLL;LDLLLVALIKGLVRRR;LLDLLLVALIKGLVRRRR;LTNLLFALLLDLLLVALIKGLV;VSRFILNHLVLAIPLRVLVV 6 28.4 0.74719 0.24076 5.33446 6.4019 6.52424 0 0 0 0 8.98299 0 5.72982 0 0 0 0 9.35848 A0A8C0RXH3 A0A8C0RXH3_CANLF SAP domain-containing protein HNRNPU Canis lupus familiaris (Dog) (Canis familiaris) "CRD-mediated mRNA stabilization [GO:0070934]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of chromatin organization [GO:1902275]; regulation of mitotic spindle assembly [GO:1901673]; RNA localization to chromatin [GO:1990280]" catalytic step 2 spliceosome [GO:0071013]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inactive sex chromosome [GO:0098577]; kinetochore [GO:0000776]; membrane [GO:0016020]; mitotic spindle microtubule [GO:1990498]; mitotic spindle midzone [GO:1990023]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; telomerase holoenzyme complex [GO:0005697] poly(C) RNA binding [GO:0017130]; poly(G) binding [GO:0034046]; pre-mRNA binding [GO:0036002]; promoter-specific chromatin binding [GO:1990841]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; snRNA binding [GO:0017069]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription corepressor activity [GO:0003714] AALDGDQMELGEE;DQGFQEGEDELGDEEEG;EDYGEKFDEND;EEEAASEDENGDDQGFQEGEDE;EFNFGQKEKP;EQKGGDKKRGVKRPREDHGRGY;GGGGGGSG;GRGNNRGYKNQ;PQPPATPQQ;SEDENGDDQGFQE;TQKKAEVEG;VEEEDEHFDDTVVCLDTCE 12 19.4 0.95181 0.04941 0 0 0 3.64062 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXM2 A0A8C0RXM2_CANLF Kinesin motor domain-containing protein KIF26B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AKYEWLMK;DEDDHRNS;GVTLYPYQISQ;ISTLGKAMVTIS;KRQALKLLLPG;LESRVNFCKAHLMMIT;VAEVIQSVVNGA;VPALQKARGD 8 4.3 0.98069 0.035491 0 3.53779 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXT7 A0A8C0RXT7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALQNHYTDLSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;DLSLSHSPG;EALQNHYTDLSLSHSPG;EDGSYFLYSKL;FLYSKLSVDKSR;FPSVLQSSGL;FVSSASTTAPSVF;FVSSASTTAPSVFPLA;GPSVFIFPPKPKD;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HTFPSVLQSSGL;HYTDLSLSHSPG;IFPPKPKD;KLSVDKSR;LPSPIERTISKARG;LQNHYTDL;LQNHYTDLSLSHSPG;LSLSHSPG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTDLSLSHSPG;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;QNHYTDLSLSHSPG;QSSGLYSLSSM;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TDLSLSHSPG;TFPSVLQSSGL;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TYRVVSVL;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VTVPSSRWPSET;VTVSWNSGSLTSGVHTFPSVL;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSKLSVDKSRWQQ;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTDLSLSHSPG 85 40.6 0.94872 0.080786 10.6056 10.4043 10.195 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXU7 A0A8C0RXU7_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] cytosol [GO:0005829] protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] DPHATFASFFGGS;PFDIFFASSRSTR;PVVHELRVS 3 10.1 1.0019 -0.68462 0 0 8.39425 0 0 0 4.63174 0 0 7.73505 0 0 0 0 0 A0A8C0RXV1 A0A8C0RXV1_CANLF P/Homo B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) peptide hormone processing [GO:0016486] extracellular space [GO:0005615]; membrane [GO:0016020]; neuron projection [GO:0043005] serine-type endopeptidase activity [GO:0004252] CDTNCSNCDQHECYWC;CDTNCSNCDQHECYWCE;CDTNCSNCDQHECYWCEEG;CHEDCLECSGPSADDC;CKACDTNCSNCDQHECYWCEEG;DDCDLCAE;DPDYEECVPCE;DSTCMPCSSPCRTCE;DTNCSNCDQHEC;DTNCSNCDQHECYWC;HCPEMCQDCIHEK;HEECTHSEYWDV;HYTCQECQGNEPSNCTSCGVD;IPCHEDCLECSGPSADDC;LDDDEEDELEYDDE;NSAVRSIYKA;RCCHCHSHSPRAA;RDYDEDDDDD;SEVGCDGPGP;TCMPHEECTHSEYWDVQ;TEEQCHSCPRDRL;VGCDGPGP;VGPAQPHVEGKF;VIHCPDGSYPD 24 10.8 0.99779 -3.3873 6.25856 13.3239 13.159 7.53869 7.00843 5.71485 3.80178 11.5632 12.3467 13.292 13.3092 10.9167 13.0418 0 10.6689 A0A8C0RXX7 A0A8C0RXX7_CANLF PLAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AFEKANVD;ASKDIFQLEAQDVGE;DEEDEEDEEEESSSEESSSEE;DLLASFDPMDMPRGNKYEVRVYT;DVATVTGPMAAYVQEGP;EDEEEESSSEESSSEEEEEET;EEARKKKEKE;EEESSSEESSSEEEEEETE;GVFDRGRMDIFHIEL;KAKLQRKKKK;KKERLKAKLQRKKKKKK;KKERLKAKLQRKKKKKKKGSD;KKKKKKKGS;LLKKERLKAKLQRKKKKKK;MPRGNKYEVRVYTG;MTVWTGDVVGGGT;NEIVREMTAEG;NNEITYYFPCQ;QLLKKERLKAKLQRKKKKK;RKKKKKKKG;SSSEESSSEEEEEETEE;TDADVFINIFGEYG;VIEEYKFEAHRW;VLPSEDEEGGGGG;VPAGRPGP;VVGGGTDSNIFMTLY 26 10.4 1.0022 -0.75705 0 0 4.09786 0 0 4.81424 0 0 0 0 0 0 0 0 0 A0A8C0RXY0 A0A8C0RXY0_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] LGPMLGASLPSETV;PSARSRGMAVI;SHCPCWAWGCCST 3 9.4 1.0011 -0.62376 14.1395 0 0 4.39122 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RXZ5 A0A8C0RXZ5_CANLF Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1) NUBP1 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] cell projection [GO:0042995]; cytoplasm [GO:0005737] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]" AGAAPDPAIEEI;DVDWGEVDYLI;SAQAGRGA;VNIPFRAI;YLIVDTPPGTS 5 14 1.0022 -1.8765 0 0 0 9.46072 0 0 0 0 0 0 11.6977 0 0 0 9.87971 A0A8C0RY03 A0A8C0RY03_CANLF CE10 protein CE10 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] peptidase inhibitor activity [GO:0030414] LQDLVKYWVCCQAHIQ;RVNIMKWLVFQLVTLY 2 21.1 0.94025 0.1011 4.1676 0 0 0 0 0 8.04734 0 0 0 0 0 0 0 0 A0A8C0RY14 A0A8C0RY14_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] GVNGWRALRWALDGKSTVCYS;VRQAPGKGLQ 2 23 0.96567 0.048461 0 0 0 0 0 5.11391 0 0 0 0 0 0 0 0 0 A0A8C0RY40 A0A8C0RY40_CANLF Metabolism of cobalamin associated A Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LKLLRKRSEVWRPKVIRISARSGE;LSGPPGAGK 2 8.2 1.0022 -0.76291 0 0 0 0 0 0 0 0 0 0 0 0 8.55616 7.39421 0 A0A8C0RY54 A0A8C0RY54_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIEWQMTI;LEMILFWIVI;SNLSFLDLCFTTTAVPQM 3 9.7 0.98756 -0.4776 9.26273 0 0 0 8.08826 0 0 0 0 0 0 7.57569 0 0 0 A0A8C0RY64 A0A8C0RY64_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) TNKS Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] NAD+ ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779] ADVHAKDK;DPTKKNRDGNTPLD;EVCSLLLSHG;GDGAAGTERKEGE;GVSTTATLGPG;GVSTTATLGPGA;IVLLQHGADP;LHVAAERAHNDVMEVL;TGDGAAGTERKEGE;VLHKHGAKMNAL 10 7.7 1.0023 -1.8438 9.29687 8.79146 12.7487 0 0 9.3535 9.51286 9.7082 9.20992 8.63249 9.50716 0 11.5605 0 12.0911 A0A8C0RY79 A0A8C0RY79_CANLF Regulator of G protein signaling 3 RGS3 Canis lupus familiaris (Dog) (Canis familiaris) AEEAEEGDEGDEEEEEEDDTSDD;DDTSDDNYGE;DEEEEEEDDT;DEEEEEEDDTSDD;EAEEGDEGDEEEEEEDDTSDD;EEEEDDTS;EGDEGDEEEEEEDDTSDDNYGER;EKLLLHKCKWGP;GAEGGSPAEEEEDAEEAEEGDE;KHLKVARRRLRPLRD;LLGEDLGRTKHLKVARRRLRPLR;SLLTPDKEISGWY;SPAEEEEDAEEAEEGDEGDEEEEEE;VPDCREPVF 14 9.1 0.99168 -0.27209 10.9219 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RY83 A0A8C0RY83_CANLF TIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TRIF-dependent toll-like receptor signaling pathway [GO:0035666] EDPGLGVTPSLP;GQDKLLRLKHKLKTL;RDDHRLAELQ;VILHAAADEHIAL 4 6.1 0.9875 -0.23115 0 9.68073 0 0 0 0 0 0 0 0 3.94458 3.91839 10.0861 0 11.6065 A0A8C0RYA3 A0A8C0RYA3_CANLF Galectin Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] LIVPFCGH;PLHPCTSLHPLHLP 2 4.6 1.0026 -0.75606 0 12.9667 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RYA6 A0A8C0RYA6_CANLF Lysosomal cobalamin transport escort protein LMBD1 (LMBR1 domain-containing protein 1) Canis lupus familiaris (Dog) (Canis familiaris) gastrulation [GO:0007369] lysosomal membrane [GO:0005765] cobalamin binding [GO:0031419] GVDEDDSDI;SLTLIGMLAAITYTAYG 2 5.6 1.0015 -0.91321 0 0 0 0 6.22257 0 0 0 0 0 0 0 9.31436 0 0 A0A8C0RYD1 A0A8C0RYD1_CANLF Follistatin like 5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] AECACMDLCKPHYKPVCGSDGEFYE;DLGQDLSDCTLYD;FNSDVTGTPYVSPD;IQGALRPPIIWKRNNI;MGNYTCYADGYEQV;MVDGVTDSVIGFN;PLIRLRHKEKSQDSSRI;QTHIFQVNV;VHISNVRY 9 15.2 1.0027 -0.79083 10.0143 11.4111 0 9.18098 0 4.43002 0 10.3346 10.4878 0 6.51322 0 0 8.30966 10.2366 A0A8C0RYD6 A0A8C0RYD6_CANLF IkappaB kinase (EC 2.7.11.10) IKBKB Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384] ACGCFCFCEE;CGCFCFCEEL;DILNLKLVHIL;RIIHRDLKPENIVLQQGE;SLPYPNNLNSILAQRL 5 7.1 1.0025 -1.3905 0 10.0861 0 5.51194 0 0 10.0918 0 0 0 0 0 0 6.14509 7.70784 A0A8C0RYE6 A0A8C0RYE6_CANLF Olfactory receptor OR2G6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LERILFVIILLFYILNILG 1 6.2 0.95466 0.04941 0 0 0 0 0 0 0 0 0 0 0 5.57537 0 0 0 A0A8C0RYE8 A0A8C0RYE8_CANLF Kinesin-like protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] LVTPHGSPARQLP;TLSTLRYANRAKSIKNKP 2 6.5 0.93793 0.059848 0 0 0 8.10852 0 8.61449 0 0 0 0 0 0 0 0 0 A0A8C0RYG6 A0A8C0RYG6_CANLF TNFR-Cys domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CDSENCVENCFRCQSCPGHVS;EVFPSLKSLEQP;IIIVIVVVVALIFLL;LEESPHPRPLEE;VLVVITITIIIVIVVVV;VLVVITITIIIVIVVVVALI 6 20.3 0.99157 -0.54872 0 0 0 0 10.2768 0 0 0 12.1468 14.8551 14.8947 14.8163 6.76924 0 9.6962 A0A8C0RYH4 A0A8C0RYH4_CANLF PHD finger protein 20-like protein 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylation-dependent protein binding [GO:0140034] CEMDEENGFMIQCEECLCWQ;KKKKKKKK;KQKKKKKKKKKSKQ;PATDGKVFSISSQNPQESSVPEVP;QKKKKKKK;SDDDDVSSFEEEQE;TSEHSYQKPQSFGQ 7 8.9 0.9913 0.0071462 0 0 0 4.37837 10.5029 0 0 0 0 0 7.7128 0 0 0 0 A0A8C0RYH7 A0A8C0RYH7_CANLF Translation machinery-associated protein 16 TMA16 Canis lupus familiaris (Dog) (Canis familiaris) AAPPPGNPKD;LEQIELHNSIKDRQGRRHYSRETVI;VIKQTMERERQQYEGYG 3 12.6 0.98975 0.016214 13.0217 0 0 0 0 9.2884 0 9.05604 0 0 0 13.7194 0 0 0 A0A8C0RYI7 A0A8C0RYI7_CANLF Oxysterol-binding protein Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] membrane [GO:0016020] lipid binding [GO:0008289] ALELALRCSSL;HQGPGPERRL;ITQPLPSSYLIFRAASE;RRTTYVEQVHEE;SETLEGCLPRRTTYVEQVHE;SSTPESCPELSDEEEEEEEE;TMELGGRVTIE 7 11 1.002 -0.67209 10.5632 6.95489 0 0 0 0 0 10.12 8.20016 0 0 0 0 7.74732 0 A0A8C0RYJ2 A0A8C0RYJ2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DTSTKAKETKAKMNYWDFMKIRSF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 6 0.99387 -0.28582 0 0 0 0 0 0 0 0 0 0 0 0 12.1808 0 0 A0A8C0RYJ5 A0A8C0RYJ5_CANLF "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3)" ST6GALNAC2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] IVSGILWTQGIKCWNEKA 1 3.3 0.9888 -0.22638 0 0 0 10.0045 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RYK7 A0A8C0RYK7_CANLF HAUS augmin-like complex subunit 3 N-terminal domain-containing protein HAUS3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; spindle assembly [GO:0051225] cytoplasm [GO:0005737]; HAUS complex [GO:0070652]; microtubule [GO:0005874]; spindle [GO:0005819] DTLYQGGNQLLLSDQELTEQFHQVE;IDTKDFSTNRLYQ;IHEVVESSNEENFQ 3 8.6 0.98772 -0.48604 0 0 10.1169 0 0 0 0 0 0 0 0 0 8.23807 0 8.70484 A0A8C0RYK8 A0A8C0RYK8_CANLF Neuronal calcium sensor 1 (Frequenin homolog) NCS1 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic density [GO:0014069] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048] DENKDGRIEFS 1 5.8 0.97993 0.035491 0 0 0 0 0 0 0 9.12195 0 0 0 0 0 0 0 A0A8C0RYL8 A0A8C0RYL8_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524] PSSLSSPSSSPPPRPPGP;YGKGGQDAHDEE 2 6.9 0.99234 -0.17738 0 0 0 0 11.0842 0 0 0 0 0 0 0 0 0 0 A0A8C0RYN1 A0A8C0RYN1_CANLF CSD domain-containing protein CARHSP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186] mRNA 3'-UTR binding [GO:0003730] LQAVEVVITHLAP 1 8.8 0.93859 0.059601 0 0 0 0 0 0 9.33103 0 0 0 0 0 0 0 0 A0A8C0RYS2 A0A8C0RYS2_CANLF G-protein coupled receptors family 1 profile domain-containing protein HTR6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993] YTYCRILLAARKQAVQVASLTTGA 1 5.5 0.97348 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 7.66384 0 A0A8C0RYS3 A0A8C0RYS3_CANLF Methyltransferase like 22 METTL22 Canis lupus familiaris (Dog) (Canis familiaris) protein methyltransferase activity [GO:0008276] AAEVFYDDDL;WNRDSQTDSGAEGGS 2 6.5 0.98801 -0.49321 0 0 0 0 0 0 0 0 0 0 0 10.0153 0 11.2113 0 A0A8C0RYU0 A0A8C0RYU0_CANLF Synaptotagmin Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488] axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905] MQNGKRLKKKKTTIKKNT;QNGKRLKKKKTT;TVLDYDKIGKNDA;WHTLQVEEEV;YYNESFSFEVPF 5 12.6 1.0021 -0.76789 0 9.25288 9.19069 0 0 0 0 0 0 0 8.16792 0 0 0 0 A0A8C0RYU5 A0A8C0RYU5_CANLF IRG-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] GIQDEDDLGQCL;LETVSSAPVS;NALREIGHDEKDSAPTGV;NYLEKIHFSQYDL;YLYSILSYIPFLGDTV 5 17 0.93788 0.10338 7.6077 0 0 10.9856 0 0 10.2334 9.84097 0 0 12.452 12.3026 0 0 0 A0A8C0RYU7 A0A8C0RYU7_CANLF Urotensin-2 receptor (Urotensin II receptor) UTS2R Canis lupus familiaris (Dog) (Canis familiaris) blood vessel diameter maintenance [GO:0097746]; regulation of blood pressure [GO:0008217] membrane [GO:0016020] urotensin II receptor activity [GO:0001604] AAVLRPLDTAQRSKGYR;AQTRRLPNPRVLYLILGIVL;LADLLYLLSI 3 11.4 0.99593 -0.57022 0 0 0 0 0 0 0 0 0 0 4.73097 0 0 0 0 A0A8C0RYW3 A0A8C0RYW3_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LFSHPSPAPGGPAGG;LMMWVKYDMQRRCNDLSMLLAFI;STVGVAAL 3 6.7 0.99312 -0.28188 0 0 0 0 0 10.2238 0 0 0 0 0 0 0 0 0 A0A8C0RYW8 A0A8C0RYW8_CANLF PX domain-containing protein SNX2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphatidylinositol phosphate binding [GO:1901981] DLERGYTVFKIE;GAPLLGGL 2 3.7 1.0042 -1.0539 8.68598 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RYZ2 A0A8C0RYZ2_CANLF P/Homo B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GVRMLDGTITDVIEA;SIHTLSVGSTTQNGRV;TALWLRLA;TDVIEAQSLSLQP 4 6.9 0.98652 -0.39617 0 0 0 11.3836 6.39486 0 0 0 0 0 0 8.97281 8.21228 0 0 A0A8C0RZ01 A0A8C0RZ01_CANLF Interleukin-13 IL13 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] cytokine receptor binding [GO:0005126] GQISSERSRDTKIEV;TAGMYCAA;VVIALTCLGGLA 3 26.9 0.98714 -0.40773 11.1757 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4597 A0A8C0RZ18 A0A8C0RZ18_CANLF Ankyrin 1 ANK1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] DIEVLEGMPLF;LHCAPSLW;LVSFMVDARGGSMRGSRH;LVTAEDSSLECSKA;SHLEWVQEAQ;SPLHQAAQQGHT;TDVLKVVT 7 4.1 1.0021 -1.8292 8.12758 0 0 4.06592 0 0 8.98655 0 0 0 0 0 11.9366 7.88411 0 A0A8C0RZ29 A0A8C0RZ29_CANLF SET binding protein 1 SETBP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DLSSEPADSC;FQPQAYERPQ;LLLGGVVPSPG;TKRYSGSGGD;TSLPTSCVD;YYAPYGMPYTSMPMM 6 4.3 1.0041 -0.80421 0 9.03757 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RZ45 A0A8C0RZ45_CANLF Zinc finger protein 773 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EQNVYLKGVLREK;KSSLINHWRVH;THEVSRLEWWREPFL 3 9.4 0.99259 -0.17488 9.09426 0 0 0 0 0 0 3.67785 0 10.5544 0 0 0 0 0 A0A8C0RZ93 A0A8C0RZ93_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] KYEERVLKKIRRKIRNKQSAQESRK;PAGCHALESGKGLCASYHPGPP;RVLKKIRRK;TQLPLTKYEERVLKKIRRKIRNKQ 4 11.8 0.99325 -0.18831 5.89377 0 0 0 0 0 10.3712 0 0 0 0 0 0 0 9.68923 A0A8C0RZ97 A0A8C0RZ97_CANLF Podocalyxin (Podocalyxin-like protein 1) Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; negative regulation of cell-cell adhesion [GO:0022408]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; regulation of microvillus assembly [GO:0032534] apical plasma membrane [GO:0016324]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; ruffle [GO:0001726] AALYGCCH;LLLLLLLL;LLLLLLLLP;LLLLLLLP;MRPAPPPPLLLLLLLL;PAPPPPLLLLLLLLPP;PPLLLLLL;PPLLLLLLL;RRRRRRRAQQRRHRPLVRRRRSSAR;SARPSAAPA;SLPSETESLESPSSES 11 9.1 1.0036 -1.0412 9.91308 0 0 0 0 0 9.61686 0 5.34844 2.47129 4.95745 0 4.15299 0 4.93937 A0A8C0RZ98 A0A8C0RZ98_CANLF CTCK domain-containing protein CCN4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] FSEENAGFILNSDVRSCF;GVCTDDRCCIPY 2 9.7 0.9895 -0.21477 0 0 0 0 0 0 0 0 0 0 0 0 10.9619 11.578 0 A0A8C0RZB2 A0A8C0RZB2_CANLF Sema domain-containing protein PLXNA4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] DRGSKMVSEIYL;EERRTQRAP;FGFILDNVQSLLILN;GGGGGGGE;GGGGGGGG;GPQWGVGGASVGCVRPRGP;HDEFVASMIKIPSDTFTVIPDFDI;LGEPFHKKE;RESCGLCLKADP;SLRSRTPMITPDLESGVKMWH;VLFPGIEDHPVLRDLEVP 11 6.5 1.0022 -1.8783 0 11.2996 0 0 10.7968 0 0 0 0 0 0 8.57645 0 9.89771 10.8661 A0A8C0RZD4 A0A8C0RZD4_CANLF Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase (EC 2.4.1.135) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872] AALSRPCGISGGSARAESGERASIQ;SRLQSWLSGPSAA 2 5.4 0.98892 -0.22637 0 0 0 0 0 0 0 0 9.21417 0 0 0 0 9.53356 0 A0A8C0RZE0 A0A8C0RZE0_CANLF Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) PIK3C3 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; endocytosis [GO:0006897]; phosphatidylinositol-mediated signaling [GO:0048015] "endosome [GO:0005768]; peroxisome [GO:0005777]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524] VELIPLPL;YEEQDLVWKFRYYLTNQEKD 2 3.3 0.98493 -0.2589 0 0 0 0 0 0 0 0 0 0 0 0 10.6766 0 0 A0A8C0RZE2 A0A8C0RZE2_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] LERIEKDQSKQGEMK;NERNARAAVAGEDGRMI 2 11.9 0.99412 -0.1887 0 10.6347 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RZF3 A0A8C0RZF3_CANLF Kinesin-like protein KIFC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GAAPPMVG;KPLRGTWVAQW;SLRFASKVNQCVI 3 4.1 1.0022 -1.3675 0 11.9829 0 0 0 0 0 7.59051 0 0 0 0 0 0 0 A0A8C0RZF9 A0A8C0RZF9_CANLF Tetraspanin TSPAN12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] HTSMANSFTTHFEMEEL 1 6.1 0.97609 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.38434 A0A8C0RZG2 A0A8C0RZG2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RALNDTLNQM 5 6.7 0.99847 -0.61146 6.51709 0 9.32847 0 0 0 0 0 7.34908 0 0 0 0 0 0 A0A8C0RZH7 A0A8C0RZH7_CANLF C2H2-type domain-containing protein ZNF644 Canis lupus familiaris (Dog) (Canis familiaris) DLQLSTPQKASQHQVLFL;HLHRHMMYHLDGNSHFRHLNVPRP;IVNSDVAQRKTQK;KDDCVDTLTGI;LSYEARHVVSPE;RNSTISPQKI;SVSLTTGQ;SYEARHVVSPE;TFSTEEPSFYPCTKCNV;YYCCEECNF 10 9.8 1.0013 -2.7061 0 9.55242 12.5868 0 11.8514 8.38534 8.01753 3.43443 14.8292 0 0 0 9.53031 0 0 A0A8C0RZL7 A0A8C0RZL7_CANLF Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) Canis lupus familiaris (Dog) (Canis familiaris) regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] early endosome [GO:0005769]; focal adhesion [GO:0005925]; late endosome [GO:0005770]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; protein serine/threonine kinase activity [GO:0004674] NLVDLQKKLAEL;VGFSHLPSLRLRTR 2 6.1 0.93548 0.060769 4.98923 0 0 0 0 0 0 0 4.06738 0 0 0 0 0 0 A0A8C0RZL9 A0A8C0RZL9_CANLF Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (N-acetyl-beta-glucosaminidase subunit beta) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] cortical granule [GO:0060473]; lysosome [GO:0005764] beta-N-acetylhexosaminidase activity [GO:0004563] GGGGGGGG;ILETLDAMAFNKF;PGGGGRDL;PGGPGGGG;VTSDESYS;YSLSHVYTPTDV;YVQKVLDIA 7 8.7 1.0018 -1.2136 0 8.31442 0 0 0 0 0 0 10.7726 9.55461 9.23805 0 0 0 0 A0A8C0RZM9 A0A8C0RZM9_CANLF ADP-ribosylhydrolase ARH3 (EC 3.2.1.143) (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (Poly(ADP-ribose) glycohydrolase ARH3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleus [GO:0005634] "hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]" GDTDTIATMAGAIAGA;GGGAVGRRGRRRRVRRPRRKWRLL;GGGGGGGA;GGGGGGGG;PESWQQSCEGYEET;SLVLHGRHGHGPGPRAVPAAKE;VGRRGRRRRVRRPRRKWRLLGADG 7 13.2 0.72727 0.26075 0 6.51762 8.02009 0 5.16302 0 0 0 0 0 0 10.8955 0 7.92297 0 A0A8C0RZN4 A0A8C0RZN4_CANLF IQ motif containing M Canis lupus familiaris (Dog) (Canis familiaris) ESVGKKMEKEKHQH;LFKSEHFKEPSQGTSFKEPYIFS;TQQQIDEVWDLVHREDRDKYSELI 3 12.2 0.97349 0.041303 0 10.4877 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0RZN9 A0A8C0RZN9_CANLF PDZ domain containing ring finger 3 PDZRN3 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EAGGAGLGPPAPRELEAG;HVLPLKRLILKLDIK;KHAHIPAHAQHYQSYMQLIQQKSAV;VLPLKRLILKLDI;WSREERKQ 5 6.4 1.0025 -0.71538 0 0 0 0 0 9.1035 0 9.7658 4.6692 0 0 0 0 7.42391 0 A0A8C0RZP2 A0A8C0RZP2_CANLF AF4/FMR2 C-terminal homology domain-containing protein AFF4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DDRNYSADHYLQE;HQSSKWTPVGPAPSTSQ;IVKIDLNLLTRIPGKPYKETEPP;RPSAEKKK;SESGRGRQKSP;SNKGKRKHKNEDD;SSGSSSRK;TDLVRYTRQ 8 9 1.0033 -2.0981 0 8.28249 5.54003 0 0 0 7.76295 0 13.7674 0 0 4.30466 11.0385 9.71406 0 A0A8C0RZP3 A0A8C0RZP3_CANLF Protein Wnt WNT16 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] AGLRGGGGP;GGGAAPGG;RSRREGREGAGQGP 3 3.7 1.0015 -0.91762 0 7.05018 0 11.2041 0 0 0 0 0 0 11.8493 0 0 0 0 A0A8C0RZQ2 A0A8C0RZQ2_CANLF Mitochondrial assembly of ribosomal large subunit 1 MALSU1 Canis lupus familiaris (Dog) (Canis familiaris) CGALSPGAGPAAGSGPR;KMYKYLKSKSEPHVKIEGKDT 2 16.1 0.93522 0.094073 0 0 0 0 9.67742 8.93614 0 0 0 10.1173 0 0 0 0 0 A0A8C0RZS2 A0A8C0RZS2_CANLF Laminin G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653] collagen-containing extracellular matrix [GO:0062023]; membrane [GO:0016020] DDSETQCDEF;EEMPLHGFLQ;EIKVAISVELRN;ESYVELNIIEVSSEF;EVQNFTVQEGGSKTLLE;EVSSEFSLQLKFQ;EYLHPSEVPLS;GVFYFSVTDGQHRP;MKVDVASEDLGIHHSQ;PGAPTEPRENSYPLMV;VHWLKVILLKNV;VSPALGMEKAF;WRVQGEGL 13 6.8 1.0015 -2.6494 9.42876 8.84216 8.22564 0 9.18854 0 15.6529 13.0463 11.6593 0 0 0 0 8.66249 0 A0A8C0RZU2 A0A8C0RZU2_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DSDDYDDDDDD;EPGAWAVVAGDEES;GALGPAADPQGSTVSRATEKSFE;GDDGDSDDYDDD;GDDGDSDDYDDDD;GDDGDSDDYDDDDD;GDDGDSDDYDDDDDD;GDGDGDGD;GDSDDYDDDD;GGDDGDSDDYDDDDDDR;IGWSYTGALNQKNWGK;LVGGGDDGDSDDYDDDDDDR;LVGGGDDGDSDDYDDDDDDRE;REFLTDGYQ;STLTSELVYPHELLTSTEG;TLTSELVYPHELLTSTE;VGGGDDGDSDDYDDDDD;VGGGDDGDSDDYDDDDDD;VLAEAPTSTASLQVS;VSRATEKSFE 20 6.3 1.0029 -1.9091 7.42063 10.9057 5.59494 9.42082 9.47748 0 10.6197 9.86358 6.34673 0 0 4.43696 4.64893 9.9477 8.91352 A0A8C0RZV1 A0A8C0RZV1_CANLF HRDC domain-containing protein EXOSC10 Canis lupus familiaris (Dog) (Canis familiaris) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" nuclear exosome (RNase complex) [GO:0000176] 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166] ASGGLPQFGDEYDFY;ESLTDPTI;FTDESYLELYRKQK;LGLTCLMQISTRTEDFI;SAFSFEKGVAPGPGQDFPHASG 5 7.9 0.97655 0.048004 0 0 0 0 0 0 0 0 0 0 6.12054 0 0 0 0 A0A8C0RZW1 A0A8C0RZW1_CANLF Torsin family 3 member A TOR3A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DCCDSEDCRISNN;LLLLLLLL;LLLLLLLLL;LLLLLLLLP;LLLLLLLP;LTSWYCSFQDCCD;PLLLLLLLLL;YCSFQDCCDSEDC;YRHVRLCARDA 9 11.1 0.98854 0.030325 0 0 0 0 4.34334 0 0 0 0 0 0 8.26716 6.09491 6.64373 0 A0A8C0RZW7 A0A8C0RZW7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;LSLFADDMILYIET;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 7.9 0.94176 0.075793 0 0 0 0 0 6.08083 0 0 0 0 0 0 0 0 0 A0A8C0RZY4 A0A8C0RZY4_CANLF DZF domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EDSSVDQEGVQVPQPN;EVSSDSEDSVIISSCEEPR 2 3.8 0.99276 -0.17617 0 0 13.5479 0 0 10.5995 0 13.5506 3.92191 13.4522 0 0 0 0 0 A0A8C0RZY6 A0A8C0RZY6_CANLF G3BP stress granule assembly factor 1 G3BP1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; intracellular organelle [GO:0043229]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] GEQGDVEPRRIVRHPDSHQLFIGN;LKKIQTIR;YKVLKKIQTIRARRSE 3 8.5 1.0016 -0.75039 6.84787 0 0 0 0 9.49877 0 0 0 0 0 0 0 0 0 A0A8C0RZZ4 A0A8C0RZZ4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LSSVVQKEPHPESPSPNI;NGSGGHGL;VGTPPPGL 3 3.8 1.003 -2.1605 0 10.2099 0 0 8.99135 0 0 0 10.062 0 0 0 0 12.3334 0 A0A8C0S013 A0A8C0S013_CANLF adenylate cyclase (EC 4.6.1.1) ADCY4 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] IHERHTERQRHRQRQKQAPR;QEQEETETMENLT;TLYFREKE;TLYFREKELEK;VIGAQKPQYDIWGNT 5 5.6 0.97426 0.048206 0 0 0 0 0 0 0 0 0 0 6.06355 0 0 0 0 A0A8C0S018 A0A8C0S018_CANLF Propionate--CoA ligase (EC 6.2.1.1) (EC 6.2.1.17) ACSS2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405] DTSTVADPTVICQL;GKPKGVVH;IMRTIYGNHERFEATYFKKFPGYY;LWWHELMQE;PKTRSGKIMR;PMKPGSATFPF 6 10.8 1.0024 -1.0043 0 0 11.3539 7.4451 8.37347 0 0 0 0 0 0 0 12.8916 8.74416 0 A0A8C0S028 A0A8C0S028_CANLF Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) PHAX Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; snRNA export from nucleus [GO:0006408] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] DAGDMEDGQLSDSDSDMT;SQEHTKELDKEL 2 8.2 0.99014 -0.2174 4.61489 0 0 0 0 0 0 8.41375 0 0 0 0 0 0 0 A0A8C0S034 A0A8C0S034_CANLF Testis expressed 43 Canis lupus familiaris (Dog) (Canis familiaris) IPRHYIMPWKENMIFRNMNL 1 14.9 0.94823 0.050068 0 0 0 0 0 0 8.78215 0 0 0 0 0 0 0 0 A0A8C0S038 A0A8C0S038_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of adaptive immune response [GO:0002819] transmembrane signaling receptor activity [GO:0004888] ATMDIQLGETGNYTEE 1 22.2 0.95656 0.049233 0 2.70684 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S040 A0A8C0S040_CANLF Gamma-tubulin complex component TUBGCP3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule nucleation [GO:0007020] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] ADAALFSELH;FEVLECSWDELWNKVQ;ILGRSEADVAQQFQYAVR;LGQGDFIRH;LVWTYDPKIRLKTL;VHFIHQMQYYITFEVLECSW;VLLTTSSDESLRFLSFRLDFNEHYE;WTYDPKIRLK;YLLDVLNRKY;YQHNLTGILE;YYITFEVLECSWDE 11 14.7 0.97844 0.035538 0 0 0 0 0 0 8.87977 0 0 0 0 0 0 0 0 A0A8C0S043 A0A8C0S043_CANLF Glutamate receptor GRIN3A Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] postsynaptic membrane [GO:0045211] transmitter-gated monoatomic ion channel activity [GO:0022824] ELDLVSSVLHIPVISIV;RVGAVHLQPWTTAPR;SLGILVRTRD;WNITDFLLLTQKNSKFHLGSVI 4 5.7 0.98659 -0.3566 9.38478 0 9.53926 0 0 0 10.5173 0 13.3044 5.22369 0 8.74231 0 0 10.5341 A0A8C0S052 A0A8C0S052_CANLF 40S ribosomal protein SA Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; small ribosomal subunit [GO:0015935] structural constituent of ribosome [GO:0003735] VGLMWWMLAREVLHM 1 5.5 0.94853 0.053889 0 0 0 0 0 0 0 7.28771 0 0 0 0 0 0 0 A0A8C0S056 A0A8C0S056_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] HLKKKKKRNVAQIFDFTK;KINLYYHLWHHLKKKKK;LKKKKKRNV 3 21.2 0.98328 -0.2538 10.3016 0 0 0 0 0 0 0 11.0185 0 0 0 6.45861 0 0 A0A8C0S061 A0A8C0S061_CANLF Large ribosomal subunit protein eL28 (60S ribosomal protein L28) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] HVGAACPS;STVSGAPG 2 4.9 1.0036 -2.2088 0 0 9.72668 0 0 0 0 0 0 10.4383 0 9.35506 0 0 0 A0A8C0S066 A0A8C0S066_CANLF Aspartic peptidase DDI1-type domain-containing protein NRIP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] PFVETVSLNEDKIS;VLPIKIIL;VLPIKIILGIFIIRTYL;YLRKIAIAFMLWIP 4 15.2 1.002 -1.293 5.01841 0 0 0 6.53182 0 0 0 0 0 0 0 3.77716 0 0 A0A8C0S080 A0A8C0S080_CANLF Major facilitator superfamily (MFS) profile domain-containing protein LOC611985 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LRQKKILKRTH;RQKKILKRTH 2 4.9 0.9845 -0.23953 0 0 0 0 0 0 0 6.33721 6.70487 0 0 0 0 0 0 A0A8C0S087 A0A8C0S087_CANLF RAS p21 protein activator 4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] PASRAKEAWME;RGPAMAKRSSLSI;VGCSGLHRPQTEAEVLEQ 3 5.4 0.84943 0.14819 0 0 0 0 0 0 0 7.42417 6.47307 0 0 15.7863 0 0 0 A0A8C0S0B1 A0A8C0S0B1_CANLF Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) MOCS2 Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] molybdopterin synthase complex [GO:1990140] molybdopterin synthase activity [GO:0030366] DLNEIEEKPKDIIK;DTLKAKVPI;GVRKDLNEIEE 3 11.7 1.0013 -0.70764 0 0 0 0 0 0 0 0 10.1718 0 0 8.28276 0 7.72226 5.38187 A0A8C0S0B5 A0A8C0S0B5_CANLF Radial spoke head 6 homolog A Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] radial spoke [GO:0001534] AAEEEEEDEEEDEDEDLD;ALAAAEEEEEDEEEDEDED;EDEEEDEDEDLD;ESFRIFMALKQ;ESFRIFMALKQL;GLSSDESFRIFMALKQ;LAAAEEEEEDEEEDEDEDLD;QTSVSCSL 8 6.5 1.0032 -1.1134 6.65978 11.6598 4.21708 0 6.06199 8.17557 0 0 0 0 0 4.98523 11.6879 11.6325 11.4605 A0A8C0S0B8 A0A8C0S0B8_CANLF LPS responsive beige-like anchor protein Canis lupus familiaris (Dog) (Canis familiaris) AVRSLNVFYYLTYE;DNLMDVLQ;EASLPTELQEDSLSPAASE;EEDDDDYV;EFILSRQRAEDIHR;ELENIEPTQGLSIEASVTF;EMNFIIQEGESIICMVDLLEKC;EQMLACKGFLVI;GLPIRGIRMKFAVLTGLVEV;HYGTHYSTASFVLAWL;IGQCSNSL;IQEGESIICMVDLLEKC;KYRDILEPQNERRNQ;LDYRQYLSDEVDLTICSTL;LMVWQVSDLKH;LVEVGEVSN;NVLFEILIE;PAFDQRNGLRVIYKL;PGVENTPSAFSPLT;PLFAQLDYRQYL;TSEEFVRINRLALESE;VESSPTEE;VLFPLFAQLDYRQYLS 23 9.9 0.99676 -4.4166 9.78177 9.1967 0 5.98605 7.732 8.85894 0 14.5674 12.8908 0 0 10.451 12.1081 10.1445 7.67384 A0A8C0S0C1 A0A8C0S0C1_CANLF Class II aldolase/adducin N-terminal domain-containing protein ADD2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EALMRMLDNLGYRTGYTYRYPFV;GRRRPRRRGRALRGRLQ 2 6.5 0.99462 -0.56057 9.03513 0 0 0 0 0 0 0 0 0 0 0 9.58492 0 0 A0A8C0S0C5 A0A8C0S0C5_CANLF LIM domain 7 LMO7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell adhesion [GO:0030155]; regulation of signaling [GO:0023051] metal ion binding [GO:0046872] AQQEAERENY;DLEMPTLDPD;EEWQRAQQEAERENYK;ENGVLLCDLVNKLKPGVIKKIN;FSGIFVASVEAGSPAEF;ISINQTPG;LQEKYQREQEKLREEWQRAQQEAER;LRYEEMQKIKSQLKEQDQKWQDDL;QKKKEEREEIE;QQDQEEQER;QRSSKKEQAPSEAELERQQILQEMR;RPIDSYDIPKREEQSSGL;RWAWDQEEERRRQERWQREQ;RWQREQDRLLQEKYQREQEKLREEW;SESGSDSED;SIPPPSSAGS;SYTMDDAWRYNGDVEDDK 17 13.3 1.0012 -2.707 0 0 9.98014 0 10.2984 6.46948 6.43984 11.1804 7.92701 0 6.17648 0 0 13.7605 7.90953 A0A8C0S0C6 A0A8C0S0C6_CANLF FMN hydroxy acid dehydrogenase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) peroxisome [GO:0005777] FMN binding [GO:0010181]; oxidoreductase activity [GO:0016491] GATAMQCMAHVDGELATVRACRS;LDGVPATIDA;LVRKNPLAV 3 11.4 1.0029 -1.0082 0 0 0 0 0 0 0 0 0 4.87214 0 5.44397 0 0 0 A0A8C0S0D9 A0A8C0S0D9_CANLF Synaptic Ras GTPase activating protein 1 SYNGAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096] AAEQALVPWTVAGTG;DLQGDGPGGRL;FLELEWGSMQ;HSHESLLS;SPAVKFACFPEYHLGRS;VLPQLSKEALLKLG 6 5.3 0.99202 -0.54958 0 8.95085 0 0 0 0 0 8.96639 10.7712 0 0 0 0 0 0 A0A8C0S0E6 A0A8C0S0E6_CANLF Large ribosomal subunit protein uL2 (60S ribosomal protein L8) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625]; organelle membrane [GO:0031090] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FAKKKKKKKEEKKEERRRERKKERK;GVNPQQCNCWVVGQ;RKKEKKERKKERKKERKKERKKKE;SSSAGGPP 4 15.3 1.0018 -0.96646 5.82467 12.6253 0 0 0 5.35885 12.7873 12.8411 12.9029 7.8226 7.55098 7.47517 0 0 0 A0A8C0S0E9 A0A8C0S0E9_CANLF CA174 protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] HTPLAGEEPHSAQQGGSTL 1 8 0.94962 0.049747 0 0 0 0 6.9514 0 0 0 0 0 0 0 0 0 0 A0A8C0S0F5 A0A8C0S0F5_CANLF Myelin regulatory factor like Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FSTKKKKKKRKKKKKKK;KKKKKKKK;KKKKKKKKKSL;KKKKKRKKKKKKKKKK;KKKKKRKKKKKKKKKKSL;KKKKRKKKKKKKKKK;KRKKKKKKKKKKSL;PPTKKRKCTEVLEDPGDCQVWAQHQ;RKKKKKKKK;RKKKKKKKKK;RKKKKKKKKKK;STKKKKKKRKKKKKK;STKKKKKKRKKKKKKKK;STKKKKKKRKKKKKKKKKK;TKKKKKKR;TKKKKKKRKKKKKKK;TKKKKKKRKKKKKKKK;TKKKKKKRKKKKKKKKKKSL;VDKDQIFMENVG 19 10.5 1.0029 -0.98541 10.9861 9.38791 9.64214 0 8.75592 0 8.18254 9.0802 9.19288 6.38222 5.78312 3.43149 9.56375 10.195 8.74403 A0A8C0S0H5 A0A8C0S0H5_CANLF BR serine/threonine kinase 1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321] DGDVSVPERKDEV;FHMPHFIP;GTTPPPSPGGGVGGAA;PGGGVGGA;VGPYRLEKT;VLEHVSGGELF 6 7.2 0.92155 0.10894 0 9.1406 0 0 0 0 0 0 0 0 0 0 0 6.8062 0 A0A8C0S0I1 A0A8C0S0I1_CANLF Protein phosphatase 6 regulatory subunit 3 PPP6R3 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase binding [GO:0019903] CHIHSSSDDE;GVILDMFFKYTWNNFLHTQVEICIA;IEPPQPRQ;SSDGEEDTES 4 8.3 1.0022 -1.362 0 0 0 0 0 0 8.63633 8.41075 0 0 0 0 0 8.71304 0 A0A8C0S0I4 A0A8C0S0I4_CANLF Sorting nexin 14 SNX14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]" AGLYFLPCSGT;ESKLTEFHGTFPDAQLP;FCENTEPRSLQDKQKRAKQT;PVLNKQELDAIV;SVLIRRIHKVDIPSIITKK 5 7.7 0.9886 -0.31937 0 9.68064 0 0 0 0 0 12.7314 0 0 0 9.36986 0 0 8.41912 A0A8C0S0I5 A0A8C0S0I5_CANLF Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase I) Canis lupus familiaris (Dog) (Canis familiaris) oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573] HTCEQGDGVGP;LLTEMAVPGQ 2 7.3 0.99585 -0.56651 0 0 0 0 0 8.74207 0 0 0 0 0 0 0 0 0 A0A8C0S0J5 A0A8C0S0J5_CANLF Aminotransferase class I/classII domain-containing protein GCAT Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058]; threonine catabolic process [GO:0006567] glycine C-acetyltransferase activity [GO:0008890]; pyridoxal phosphate binding [GO:0030170] DLEAKLQEAQ;EFGAGLSSTRFICGTQ;LASCMADDML;PPSTLTEGPFGQPS;RVITSRQGPRI;TDELLGVMDQVTI 6 15.1 1.001 -0.92591 0 10.7573 0 0 0 8.16927 0 0 0 0 0 0 0 9.78961 8.92264 A0A8C0S0K0 A0A8C0S0K0_CANLF TRASH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270] CQKNFSCGGESFAGQGISNWK;EINVSSAFSIICDETTDSAT;ISDGLCHP;IYVRYPQKMSKA;MGQVDEIKTE;VGLTYCYTVSSLFR 6 7.5 1.0027 -1.5087 0 0 0 5.10739 0 0 12.1329 0 9.37936 7.18319 0 0 0 0 8.36418 A0A8C0S0M2 A0A8C0S0M2_CANLF Cytoskeleton associated protein 4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ETLLAKSEEQ;LETLLAKS;LFSRQREELGQGLQG;LQGVEQKVQSLQATFGTFESIL;VLEEVQQVRHGHQLFSR 5 10.5 1.0024 -0.84313 10.0699 0 0 0 4.67124 0 10.5247 8.59208 0 0 0 0 0 9.02439 0 A0A8C0S0N3 A0A8C0S0N3_CANLF V-type proton ATPase subunit a ATP6V0A1 Canis lupus familiaris (Dog) (Canis familiaris) vacuolar acidification [GO:0007035] "clathrin-coated vesicle membrane [GO:0030665]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" IDVTQKCLIAEVWCPVTD;LTELKFILRKTQQFFDEAELHHQQM;MVHQAIHTIEY;PTYNKTNKFTYGFQ;YFGFIPEIIFM;YNWTEETLRGNPVLQ 6 11.6 0.97884 0.035538 0 0 0 0 5.46163 0 0 0 0 0 0 0 0 0 0 A0A8C0S0Q5 A0A8C0S0Q5_CANLF Olfactory receptor family 13 subfamily P member 3 OR13P3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MVMYMKPG;PLSLILVIYVNIF 2 6.7 1.0044 -1.0445 0 6.64587 0 0 0 0 0 7.29554 0 0 7.815 7.73084 0 0 0 A0A8C0S0S1 A0A8C0S0S1_CANLF Nephrocystin 4 NPHP4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoskeleton [GO:0005856]; non-motile cilium [GO:0097730] ITTMHTIH;KNEEAFCVKRVEVHLLA;SRKVGSSSKTSSGNQ;TIEVDNPELSIIQD;VGHVCEQRVRDSS 5 4.7 0.98481 -0.2575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.99317 A0A8C0S0T3 A0A8C0S0T3_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] DASCCSPSCYSSSCYSA;IDEVLSEN;QFVTGTSSVPYEGFAAL;SCEACDASCCS;SCEACDASCCSPSCYSSSCYS;SLPSAQGASDD;TVFSSQDEDDEE;VEPETKIC;VTFVGEEGLDYSGP 9 5.9 0.264 0.70425 0 0 3.14129 0 10.6574 0 0 10.4035 11.8288 8.69418 9.20584 0 0 0 8.91764 A0A8C0S0U6 A0A8C0S0U6_CANLF "Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2" APPL2 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; ruffle [GO:0001726] QTRSLLSVFEEDAGTL;RNSEMENDRIVPTAEL 2 4.9 0.96058 0.049233 0 0 0 7.5549 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S0W3 A0A8C0S0W3_CANLF Maestro heat like repeat family member 5 (gene/pseudogene) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LILQAEDNST;SLELEEVYQDAASDVLLAICRHSW 2 8.1 0.99368 -0.28595 0 0 0 0 0 0 0 0 0 0 0 0 0 9.72952 0 A0A8C0S0X6 A0A8C0S0X6_CANLF HEAT repeat containing 4 HEATR4 Canis lupus familiaris (Dog) (Canis familiaris) FHFSPYRCTHLKNQ;RWTSQPVPEA;VLQPALEAALCDK;VLQPALEAALCDKNANVRMAAA 4 4.7 1.0032 -1.0571 0 0 0 0 0 0 10.0951 0 9.95818 9.29069 0 0 0 9.8822 0 A0A8C0S0Y6 A0A8C0S0Y6_CANLF Collagen alpha-1(I) chain-like Canis lupus familiaris (Dog) (Canis familiaris) GVAGARGRPEAP 1 1.8 0.98563 -0.2354 0 0 3.56596 0 3.5735 0 12.2401 0 0 0 0 0 4.06987 3.69388 0 A0A8C0S103 A0A8C0S103_CANLF Zinc finger protein 2 Canis lupus familiaris (Dog) (Canis familiaris) urogenital system development [GO:0001655] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AFFDRSSLTQHQKIHTGDKPYE;SLTRHQRIHTGES 2 9 0.98922 -0.52548 0 0 9.31823 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S104 A0A8C0S104_CANLF Dynein axonemal assembly factor 5 DNAAF5 Canis lupus familiaris (Dog) (Canis familiaris) FLKLILSTLKKSPSPAGLLV;IQFGNGKSVDDVLP;LDLRDRYS;VLSEEQIQ 4 5.8 1.002 -1.8245 0 0 0 0 0 0 9.10907 0 0 0 0 0 0 0 8.52344 A0A8C0S117 A0A8C0S117_CANLF Myb-like domain-containing protein EZH2 Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin formation [GO:0031507] ESC/E(Z) complex [GO:0035098] chromatin binding [GO:0003682]; histone H3K27 methyltransferase activity [GO:0046976] DDDDDDDGDDPD;DDDDGDDP;LTSLDFTLLMSKI;LVNALGQYNDDDDDDDGDDP;NDDDDDDD;NDDDDDDDGDDPDEREEK;SVQREQSLHSFH 7 12.1 0.93872 0.072032 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.0452 A0A8C0S124 A0A8C0S124_CANLF Chloride intracellular channel protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] LRRRLPKGLPKALRVL 1 8.9 0.96053 0.049233 0 0 0 0 0 8.82394 0 0 0 0 0 0 0 0 0 A0A8C0S141 A0A8C0S141_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RGARAGRACSGLGAGPG 1 4.3 0.97984 0.046227 0 9.98214 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S161 A0A8C0S161_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGFSSFGELQ 1 3.6 0.03125 1.0808 12.2652 0 0 10.8225 10.8779 0 0 0 0 12.0652 0 12.1069 11.9096 0 0 A0A8C0S173 A0A8C0S173_CANLF Major facilitator superfamily domain containing 4B MFSD4B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ASMATTFPSGVSWIEQYTTIH;EENEEEDAEKWNEMDFEVIEMNDTM;GAEVTYGS;HSALNQSSEADSESL;KTAVLLIIMMSVFG;MAIPAVIG;VGRAFGFLSGS 7 20.1 1.003 -0.79623 2.52622 0 10.36 12.1462 0 8.02092 6.15696 8.57622 0 0 0 3.01382 3.36219 9.34196 8.50355 A0A8C0S179 A0A8C0S179_CANLF RUN and FYVE domain containing 1 RUFY1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; regulation of endocytosis [GO:0030100] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] metal ion binding [GO:0046872] GVALRAAAALGGADG;SEKEQRQALQ;SEKSVEELEKELELQ 3 6.1 0.99803 -0.60191 0 10.0829 12.198 0 8.89339 0 0 0 0 0 0 0 0 0 0 A0A8C0S188 A0A8C0S188_CANLF Cytochrome P450 3A (EC 1.14.14.-) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" PDPFLLSIILFPFLT 1 4 0.9574 0.053875 0 0 0 0 0 0 0 7.32841 0 0 0 0 0 0 0 A0A8C0S198 A0A8C0S198_CANLF Family with sequence similarity 53 member A Canis lupus familiaris (Dog) (Canis familiaris) AEGEGGSSGDPSDWD;GSSGDPSDWDSAGEEGVFP;PSSASGGCMDSCEGSSGLPRR 3 12.2 0.84956 0.15094 0 0 0 6.51839 0 0 9.62024 0 0 5.74341 0 0 0 0 0 A0A8C0S1A2 A0A8C0S1A2_CANLF Protein kinase C (EC 2.7.11.13) PRKCE Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872] DLALTLTLLLANRVTL;RRRVHQVNGHK;YIAPEILQELEYGPSVDWW 3 6.3 0.86823 0.13457 0 0 0 0 0 4.95457 0 8.75211 0 4.48278 0 0 0 0 0 A0A8C0S1C0 A0A8C0S1C0_CANLF Zinc finger CCCH domain-containing protein 15 ZC3H15 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosol [GO:0005829] metal ion binding [GO:0046872]; mRNA binding [GO:0003729] AEDPRPHAP;EKRSVYIDARDE;GGGGGGGG;GRPVAKAAIGRRASASLSVRCGG;KEEKEDEISLED;MMMIDGSDGDGDEGWGCGQ;WKKRKRQEKID 7 15.4 1.0027 -1.1916 9.10813 10.7844 0 0 0 0 0 0 0 7.18071 0 0 0 0 6.42363 A0A8C0S1C2 A0A8C0S1C2_CANLF "Troponin T, slow skeletal muscle (Slow skeletal muscle troponin T)" Canis lupus familiaris (Dog) (Canis familiaris) regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; slow-twitch skeletal muscle fiber contraction [GO:0031444] troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin T binding [GO:0031014] LNIDHMGEDQLREKAQ;RSMRRSSPKKRRLRRRRRKVR;RSMRRSSPKKRRLRRRRRKVRP;SPKKRRLRRRRRKV;SPKKRRLRRRRRKVRPGPA;WDKSLIRGSTPCALF 6 19.5 0.99136 -0.27561 0 4.60591 6.0924 0 10.8714 0 7.09138 0 0 9.11985 0 0 0 4.96463 0 A0A8C0S1D2 A0A8C0S1D2_CANLF BOS complex subunit NCLN (Nicalin) NCLN Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] HTDSSLLQDNVAF;MVFPVAAGTPSASLT 2 4.5 0.91912 0.11364 0 0 0 0 0 0 0 9.30319 0 0 0 8.4882 0 0 0 A0A8C0S1G5 A0A8C0S1G5_CANLF PX domain-containing protein SNX10 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] AGGDAGGC 1 2.1 1.0047 -1.1044 0 0 0 0 5.93537 0 0 0 0 0 0 0 0 0 0 A0A8C0S1H4 A0A8C0S1H4_CANLF HMG box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] ELEVYRQQRNTRKGLQGSRA;KARYQEEMMN;VGKKKKRRKRDPQAPRRPP 3 26.2 0.99039 -0.51206 0 0 0 0 5.18678 0 0 11.5957 0 0 0 0 0 7.03793 0 A0A8C0S1J0 A0A8C0S1J0_CANLF LUC7-like 2 (S. cerevisiae) LUC7L2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA splice site recognition [GO:0006376] U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729] DQDLASRDRDR;ECLKVHDLALRADYEIASKEQ;MEAGYRVQCIYA;SPRDRDRKDKK;VEQLGAEGNV 5 15.3 0.98818 -0.34674 0 0 0 0 7.86542 3.90516 0 0 11.0417 0 0 4.20351 0 0 0 A0A8C0S1J4 A0A8C0S1J4_CANLF Eukaryotic translation initiation factor 2D EIF2D Canis lupus familiaris (Dog) (Canis familiaris) formation of translation preinitiation complex [GO:0001731] translation initiation factor activity [GO:0003743] AVGAAMST;ESIMADPAMQEDLRCLT;SRTLQEQMDELLQRCFLHALKC 3 8.1 0.98842 -0.47489 0 0 0 0 9.95296 0 7.01981 9.90132 0 9.65333 0 0 0 0 0 A0A8C0S1K8 A0A8C0S1K8_CANLF CD74 molecule CD74 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955]; intracellular protein transport [GO:0006886]; protein trimerization [GO:0070206] extracellular region [GO:0005576]; membrane [GO:0016020] MHC class II protein binding [GO:0042289] EAGLPSDKCTCCSL;QCYGSTGYCWCVFP 2 6.5 0.90493 0.12175 0 0 0 0 0 0 6.48354 0 0 0 0 0 0 0 10.3883 A0A8C0S1L9 A0A8C0S1L9_CANLF Zinc finger MYM-type containing 3 ZMYM3 Canis lupus familiaris (Dog) (Canis familiaris) LERSCTRSAMAAW;STESRRSGTPRTPLW 2 8 0.99338 -0.06225 0 0 0 11.737 0 0 0 0 10.7494 0 0 0 0 0 0 A0A8C0S1M1 A0A8C0S1M1_CANLF Mastermind-like 1/3 transactivation domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of Notch receptor target [GO:0007221] transcription coactivator activity [GO:0003713] EQRQQQQQQQQQQQQQQQQ;GASPAGPG;QHNILTYGNTKPLT;VPSGGFGP 4 7.4 0.95356 0.049538 0 0 0 0 0 0 0 10.069 0 0 0 0 0 0 0 A0A8C0S1M5 A0A8C0S1M5_CANLF Acyl-CoA thioesterase 4 Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637] thiolester hydrolase activity [GO:0016790] DERGALFRAHARYRA;NFEDLPKEIDSVDL;RSELYAQIASERLQAH;VAFSGILD 4 12.6 0.96279 0.049233 0 0 0 0 0 0 0 0 0 0 4.5109 0 6.08863 0 0 A0A8C0S1N1 A0A8C0S1N1_CANLF Major prion protein Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] metal ion binding [GO:0046872] FSKQSSNTF;GQGGGSHS;IMERVVEQM;PDQVYYRPVDQ 4 14.6 1.003 -2.3092 0 0 0 0 6.11772 0 0 0 0 0 0 0 0 11.931 0 A0A8C0S1Q0 A0A8C0S1Q0_CANLF glycogenin glucosyltransferase (EC 2.4.1.186) GYG1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737] glycogenin glucosyltransferase activity [GO:0008466] AAPDPGWPDCFNS;LFEREELSAAPDPGWP;PDCGCGGP 3 6.7 1.0026 -1.3548 0 0 0 0 0 0 0 0 0 0 0 0 9.03513 0 0 A0A8C0S1Q9 A0A8C0S1Q9_CANLF Guanine nucleotide-binding protein subunit alpha GNA15 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200] heterotrimeric G-protein complex [GO:0005834] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] EEDRKGFRPLVYQNI;KSTSVILF;LLLGPGESG 3 8.6 1.0026 -1.1803 0 0 0 7.32607 7.15036 0 0 0 7.36177 7.14384 0 6.81698 0 8.34096 0 A0A8C0S1R0 A0A8C0S1R0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;EALVILKRKPR;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 8.3 0.97991 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 4.23764 0 A0A8C0S1R1 A0A8C0S1R1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GVMVIEMVDGEP;SGGPQESSR 2 3.6 0.94175 0.05044 0 0 0 0 0 0 0 0 0 0 0 8.86768 0 0 0 A0A8C0S1R4 A0A8C0S1R4_CANLF FERM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] GGAGPGARLPAAADMGC;PQLPGSRLPRAPGPEPPRPQE;QENDMVDSAPQW;QGAPATAP;RILAPSPVKSFKKAKNENSPDA 5 6.3 0.98588 -0.43458 10.1649 0 0 0 0 0 0 10.6067 0 7.72451 0 0 8.83924 0 0 A0A8C0S1U5 A0A8C0S1U5_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GIHSDRQQLLHQP;QERLRPGLHRRLH 2 5.2 0.99001 -0.19883 0 0 0 0 0 0 0 0 7.80213 0 0 0 0 7.76613 9.29096 A0A8C0S1W3 A0A8C0S1W3_CANLF UV-stimulated scaffold protein A Canis lupus familiaris (Dog) (Canis familiaris) response to UV [GO:0009411] DAGRPLHEEDRTREQRQQQ;DEDNDDDDDDGDF;EDNDDDDDDG;IKCVFFVSALKSIW;TGAKEEEGDSDGDSDSDSDSDGE 5 10.1 0.98667 -0.39289 9.8389 0 6.21308 0 0 0 0 5.361 7.75087 0 0 0 5.11449 0 0 A0A8C0S1Z1 A0A8C0S1Z1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WEAHSHSCCPGPC 1 7.5 0.93992 0.059561 0 0 0 7.06673 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S202 A0A8C0S202_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGG;GYDLGYTAAYT;SLGLTQTQVGLGAGGGRGEGAGLG 3 20.8 0.98954 -0.51983 11.7204 0 0 0 0 0 0 10.7745 0 0 0 0 0 0 0 A0A8C0S209 A0A8C0S209_CANLF Amine oxidase domain-containing protein SMOX Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] oxidoreductase activity [GO:0016491] ADVEKLAKP;MAPMQVLFSGE 2 3.6 1.0026 -0.76872 0 0 0 8.90824 0 0 0 0 0 0 6.43441 6.42811 0 0 0 A0A8C0S215 A0A8C0S215_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA (cytosine-5-)-methyltransferase activity [GO:0003886] AGVFVWRV;GFGDSGGLLHRLRGVQG;PKEEKNPYKE;TASWSVHTYHHDDDSYQSYHT 4 15.3 1.0032 -1.5827 9.97971 4.80916 0 0 0 0 0 0 8.5713 0 0 0 0 0 0 A0A8C0S231 A0A8C0S231_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IYAEAWLWYW 1 17.5 0.99957 -0.61146 0 0 0 0 0 0 0 0 5.37726 0 0 0 0 0 0 A0A8C0S233 A0A8C0S233_CANLF Photoreceptor cadherin (Protocadherin-21) Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AGPARWAV;AKDRGSPSFSTTALLKI;TEGKYSLAEVFVTLLDVN;TFYGESGP 4 6.2 0.97947 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.65285 A0A8C0S284 A0A8C0S284_CANLF SNRPN upstream reading frame protein SNURF Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] NQECQLYPRRSQQQ 1 19.7 0.93906 0.060769 0 0 9.43873 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2B1 A0A8C0S2B1_CANLF Telomeric repeat-binding factor TERF2 Canis lupus familiaris (Dog) (Canis familiaris) protection from non-homologous end joining at telomere [GO:0031848] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" double-stranded telomeric DNA binding [GO:0003691]; protein homodimerization activity [GO:0042803] ENLDCSFDM;ETWVEEDEL;GVQKYGEGNWAAI;KQKWTVEESE 4 8 1.0037 -1.6065 0 0 0 0 0 0 0 0 0 0 0 0 8.47877 10.9408 0 A0A8C0S2B6 A0A8C0S2B6_CANLF Palmitoyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] CHHCSVCDKCILRMDHHCP;DKNGFSLGFS;EQVVCLTAYHLLF;QVFADEKKYWL 4 15.3 0.99571 -0.19035 0 0 0 0 0 0 0 0 0 0 4.90473 0 0 0 8.2417 A0A8C0S2D1 A0A8C0S2D1_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2H Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] nucleus [GO:0005634] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] CLDVINQTWTALYDLTNIFESFL;MNKIFHPNIDEASGTV 2 22 0.92847 0.095698 0 0 11.1157 0 0 0 0 0 8.9537 0 0 0 0 0 0 A0A8C0S2F0 A0A8C0S2F0_CANLF "Golgi associated, gamma adaptin ear containing, ARF binding protein 1" GGA1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] early endosome membrane [GO:0031901]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] AIPPWPGASLHTPVGPSFLAPS;DPTPPPGPS;PHCQREWER 3 5.6 0.99304 -0.55587 0 9.37942 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2G2 A0A8C0S2G2_CANLF Vomeronasal type-1 receptor CANFAMV1R559 Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] ISSDIIFGIFFL 1 3.9 0.95358 0.05044 0 0 10.8821 0 0 0 0 0 0 0 0 0 9.91431 0 0 A0A8C0S2G3 A0A8C0S2G3_CANLF Ig-like domain-containing protein LRIT2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALVIALHVQ;TVPILVLALHNNPWL 2 4.7 0.99205 -0.28743 0 4.54455 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2H8 A0A8C0S2H8_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SILFLFLSLV 1 4.7 0.98882 -0.22689 8.68759 0 0 0 0 0 0 0 0 0 0 7.8071 0 0 0 A0A8C0S2K0 A0A8C0S2K0_CANLF HNH nuclease domain-containing protein ZMYND19 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020]; synapse [GO:0045202] HLNAVTVDNRLDNL;PGGREGAGRPCSCSSH;QQLPTDPIE;VEEEETSCTYYE 4 12.3 1.0025 -0.958 8.21301 0 0 0 0 9.50001 0 0 0 0 0 3.05613 0 8.04625 0 A0A8C0S2K4 A0A8C0S2K4_CANLF Protein kinase domain-containing protein CDK13 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription elongation by RNA polymerase II [GO:0032968] cyclin/CDK positive transcription elongation factor complex [GO:0008024] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] EDKDTDSLRGN;GAGASQTN;GVLPSSQLKP;KVITLWYR;LGGGGGLS;PKKQYRRKLREE;RSRTKSSK;TDPHAGVKAAL 8 5.3 0.98876 -0.26241 0 3.79514 0 8.04909 0 0 0 9.6312 0 0 4.4188 0 4.11162 0 0 A0A8C0S2M3 A0A8C0S2M3_CANLF Piezo-type mechanosensitive ion channel component Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] CTVWTCVIIVCKMLY;DMSSSSADSG;EEKQERRKEEEMEEDDDQD;EKEDITVAELE;KSIPSKEDSAIYSHAKVN;LLIPLFSEP;LSFVYLIYLLLIPL;RDDSAGQSHMAVSPDDS;SEKRYPQP;SQENEEKDDEQDIQMEGDA;VDQGGEATGNV;VEAEQDDEAVAAD;VKCVYFGLSAY;VMYKIIYMVLFLFCVALYQVHYEWW;YFPDFIVRPN 15 7.3 0.97996 0.048313 0 0 0 0 0 0 0 6.82858 0 0 0 0 0 0 0 A0A8C0S2P5 A0A8C0S2P5_CANLF CD1b molecule CD1B Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] AAQEAAGLSCRVK;FQMQYPFEIQGVAGCQLHPD;PEAWLSAGPSPGPG;PSPGPGRLQLVCHVSGFYPK;YPGGGGEAAPADLQ 5 23.8 0.99012 -0.20219 9.53479 0 0 0 8.22689 6.71301 0 0 0 0 12.6785 8.2268 0 0 0 A0A8C0S2Q6 A0A8C0S2Q6_CANLF glucuronosyltransferase (EC 2.4.1.17) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] AELWFVNSDFAFDFARPLLPN;GVIWKYNPSHWPKDVKLAAN;VGWIDHILQTGGAA;YVPVFHSL 4 11 0.98742 -0.35136 0 6.83466 9.96154 8.51428 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2Q8 A0A8C0S2Q8_CANLF Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737] DELVGNLYSCIGN;ELYVDKEY;KAETLYTMGDFEFALVFY;KAINNSVG;LRERREREEATELE;QKPSGELSRRESEELE;YASERDRKLMQE 7 11.4 1.0031 -1.9587 0 0 9.42595 7.03903 9.31587 0 6.2933 9.67523 0 0 0 0 0 0 6.00995 A0A8C0S2R0 A0A8C0S2R0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RGGAESLYSPIDEHLGCFH 1 5.7 0.95197 0.049882 0 0 0 0 0 0 0 0 0 0 0 0 6.33956 0 0 A0A8C0S2R1 A0A8C0S2R1_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 2 ADAMTS2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] PPAGAARRLLCPALLLLLLPPPLLL 1 4.6 0.97405 0.035538 0 0 10.1083 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2S3 A0A8C0S2S3_CANLF Groucho/TLE N-terminal Q-rich domain-containing protein TLE2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] AGNLGRTPPRVISGAGRGPLPK;ALPLTPLPVGLQPPSLP 2 9.3 0.98957 -0.21639 0 0 7.86759 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2S4 A0A8C0S2S4_CANLF Purple acid phosphatase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872] GVLRRKFYIHRVTLGLL 1 5.2 0.99299 -0.27869 0 0 0 0 0 0 7.55451 7.00977 0 0 0 0 0 0 0 A0A8C0S2T0 A0A8C0S2T0_CANLF TNFR-Cys domain-containing protein TNFRSF11B Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] extracellular region [GO:0005576] EQTFQLLKLWKH;HYYTDLWHTSDE 2 6.6 0.99436 -0.12339 12.2391 12.2397 12.5216 8.19771 0 9.48892 11.0748 9.00874 12.9104 10.9124 11.8102 11.2656 12.8105 11.8889 11.5985 A0A8C0S2V4 A0A8C0S2V4_CANLF DUF4685 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVGGGGWWPSGSS;HTILKRGRPKGYRLLLPSTK;RARGRGGPLLP;RLPALPTAA;SLVLHTILKRGRPKGYRLL 5 13.3 0.98681 -0.40937 0 0 10.1579 0 0 0 0 0 0 6.92505 0 11.4359 0 7.36632 11.228 A0A8C0S2V5 A0A8C0S2V5_CANLF Coiled-coil domain containing 196 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGTRFWVSRIMPWTK;FIYSWRHTQR;KVLKTPSLLKKT 3 11.3 0.9947 -0.18929 0 0 0 0 4.12151 0 0 0 6.56313 0 0 0 0 0 0 A0A8C0S2V8 A0A8C0S2V8_CANLF PHD-type domain-containing protein SETDB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] CRLFDDTFVNFQAGSLRTGTTSFPS;EDGRHTDATVKIDFL;LSAAFHPQD 3 14.8 0.99207 -0.29502 8.46246 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2W1 A0A8C0S2W1_CANLF Cilia- and flagella-associated protein 45 Canis lupus familiaris (Dog) (Canis familiaris) axoneme [GO:0005930] QEKAQDYQAEQDAL;QEKLADQMVMEFTKKK;RIRGRRHIVEQMEK 3 8.6 0.98655 -0.45902 10.0316 0 0 0 8.74953 0 0 0 0 0 0 0 0 0 10.0522 A0A8C0S2W5 A0A8C0S2W5_CANLF CD1c molecule CD1C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYEGSDFVTF;EQQGTQRGDILP;PLECILLAALLL;SGTIIFLHTWSKGNFSDEEL;VLACGFGSCSFAPCPAYFV;VLYWGHHVPMYLILL;YLILLAVTVPLVLLIVL 7 28.8 0.9496 0.053996 0 0 0 0 0 0 9.62428 0 0 0 0 0 0 0 0 A0A8C0S2X0 A0A8C0S2X0_CANLF Galactose-1-phosphate uridylyltransferase (EC 2.7.7.12) GALT Canis lupus familiaris (Dog) (Canis familiaris) galactose metabolic process [GO:0006012] membrane [GO:0016020] cytokine receptor activity [GO:0004896]; UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270] EQMSSSCSG;LVSAVSPCPQAWGPPG;VTLPLMSVPEIR;YENFSCTWSP 4 6.1 1.0036 -1.0644 0 0 0 0 9.82284 9.90179 0 0 0 7.54928 0 13.0465 0 0 0 A0A8C0S2X1 A0A8C0S2X1_CANLF Syntaxin N-terminal domain-containing protein TSNARE1 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] membrane [GO:0016020] EDAEVRDALWEGRGPA;GVAVEGRGTPEPASPPAAG;INSSVSSLEQSLRSLGTPS;PIGDRVPCSPTG 4 8 0.81176 0.20649 0 10.5818 0 0 0 9.70964 8.97576 0 0 0 0 0 0 0 6.05769 A0A8C0S2X5 A0A8C0S2X5_CANLF Zinc finger protein 397 ZNF397 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] EREFDDPGQQQ;GEKPYECNECGKTFSQ;SSLTQHQRIHTGE;STLVPQNSQDQELIL 4 10.4 0.98296 -0.25395 0 0 0 0 0 0 0 0 15.321 0 0 0 4.95429 0 0 A0A8C0S2X9 A0A8C0S2X9_CANLF Immediate early response gene 5-like protein Canis lupus familiaris (Dog) (Canis familiaris) EDDEEDAGDLGAEPPGGAPFAPCK;PGCAALQPPHGAPHRGQP 2 10.3 0.92973 0.1068 4.14168 0 0 0 0 0 0 0 0 0 6.18707 0 0 0 0 A0A8C0S2Y1 A0A8C0S2Y1_CANLF Pantothenate kinase 2 Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] GSGGSGGCC;LTGCTTFEEALEMA;NIAASQGRH 3 4.2 1.004 -0.80421 7.69808 8.59205 8.83611 7.04133 6.72615 6.10003 0 6.18702 0 6.4871 7.52482 6.7305 7.91946 7.80845 0 A0A8C0S2Y4 A0A8C0S2Y4_CANLF "Inositol 1,4,5-trisphosphate receptor" Canis lupus familiaris (Dog) (Canis familiaris) release of sequestered calcium ion into cytosol [GO:0051209] endoplasmic reticulum membrane [GO:0005789] "inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]" AHDENVLSYYRYQLKLFARMCL;EPVLQHFVHLL;EVSPREVGHNIYI;LDRQYLAIDEISQQL;MASSALWGWWMTA;MEWQRKLRSMPLIYWFSRRMTLW;QELICKCVLDSKNSDILIQTEL;SRHNKQLQHLLKPVKRI;SVNCNTSW;VAVNMNDLGSQPREDREP;VGERVQSNEMGM;VGNRGTFIRGYKA;WNYLYFIV 13 7.3 0.9875 -0.32609 0 0 0 0 0 0 10.588 0 15.3256 0 0 4.56206 0 0 0 A0A8C0S2Y6 A0A8C0S2Y6_CANLF SEC7 domain-containing protein ARFGEF2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012] Golgi apparatus [GO:0005794] guanyl-nucleotide exchange factor activity [GO:0005085] AHASMYYPYLCEIMQ;APDSGAPG;DVWDETCSCM;GVQLQIIKA;HQVATRFS;LLLLLLTKTLKI;LTVMFEIMKSYGHTFEKHWWQDLFR;PVGMEEDS;RKFFLRIGVVYKIWIPEEP;SLLLLLLTKTL 10 6.5 0.99908 -3.1287 7.58864 8.96029 9.05921 7.00326 4.64962 0 0 0 0 4.86057 0 9.41867 9.3313 0 9.04037 A0A8C0S2Y8 A0A8C0S2Y8_CANLF Acid sensing ion channel subunit family member 4 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] membrane [GO:0016020] ligand-gated sodium channel activity [GO:0015280] HKETIEERDKQQQRQQ;HQLADMLKSCNFSGHH;LVLDVFFEALTSEAM 3 7.6 0.95937 0.049233 0 0 0 8.38526 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S2Y9 A0A8C0S2Y9_CANLF C2H2-type domain-containing protein ZFX Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AGLGRLAKQKPKKRRRPDSRQY;LGRLAKQKPKKRRRPDSRQYQ;SNCEDYLMISL 3 4.5 0.98626 -0.42117 0 0 8.94155 0 0 0 0 9.35716 0 0 10.5032 0 0 0 0 A0A8C0S300 A0A8C0S300_CANLF Two pore segment channel 3 TPC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] FARDHYCKNNFNDLA;ILRILRLLRIIVSIQRFRLIVT;IVLILRILRLLRIIVSIQRF;IVVVILIVNIFVAFILE;LDIVLILRILRLLRIIVSIQ;LILRILRLLRIIVSIQ;LRILRLLRIIVSIQRFRLI;QRMVRHRIFVWVYDVI;SEVETAIEKKIQ;VLILRILRLLRI 10 11.3 0.98018 0.046227 0 0 0 4.16173 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S309 A0A8C0S309_CANLF methylated diphthine methylhydrolase (EC 3.1.1.97) Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] EACTVSVSHTLS;ENILATGSYDEHILLWDTRNMKQ;LDRDPPLPLSP;TPAPTPAATPSALTADP 4 8 0.98606 -0.41678 0 0 0 0 0 9.95566 0 0 6.72383 0 0 0 0 0 0 A0A8C0S319 A0A8C0S319_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ANPSLSPSSHAG;SNSGGEVTYSV;VGSATSLQFSDQDGV 3 5 1.0033 -0.78893 0 0 0 0 0 0 0 0 0 0 0 9.84103 0 0 0 A0A8C0S326 A0A8C0S326_CANLF CD1c molecule CD1C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYEGSDFVTF;EQQGTQRGDILP;LHFTYPFEIQVVVGC;LVLLIVLLWFRKR;PLECILLAALLL;SGTIIFLHTWSKGNFSDEEL;VLYWGHHVPMYLILL;YLILLAVTVPLVLLIVL 8 30.9 0.98935 -0.31793 5.1285 0 0 0 0 7.87314 0 0 0 8.77452 0 0 6.78437 10.9895 0 A0A8C0S346 A0A8C0S346_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phototransduction [GO:0007602]; visual perception [GO:0007601] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881] FLAFVSQTCPGASL 1 4.1 0.94214 0.0611 0 0 0 0 0 0 0 0 0 0 9.73753 0 0 0 0 A0A8C0S353 A0A8C0S353_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] FSTFYHACDQ;GVSIWVTILC;LSISLQANQT;SEAEATVYFRYG;SMMTSDNYYYTHSIWHML 5 8.6 1.0042 -1.0789 11.4809 0 0 4.70819 0 0 0 9.50002 0 0 0 0 0 0 0 A0A8C0S354 A0A8C0S354_CANLF Kinetochore protein Nuf2 N-terminal domain-containing protein NUF2 Canis lupus familiaris (Dog) (Canis familiaris) Ndc80 complex [GO:0031262]; nucleus [GO:0005634] EFLWQYKSSLDKMHQLN;KNSRQEVMEKYEIYRD;TVIEDCNKVQE 3 10.5 0.99142 -0.14488 0 0 0 0 0 0 0 0 11.013 0 0 0 0 6.39818 6.36658 A0A8C0S360 A0A8C0S360_CANLF Transmembrane 9 superfamily member TM9SF5 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to membrane [GO:0072657] membrane [GO:0016020] EDFGWKLVH;QAVRSEAFYL;YILESMPHTNIQ 3 5.3 0.98733 -0.3641 0 6.12602 0 0 0 0 0 10.2293 0 0 0 9.70544 0 0 0 A0A8C0S370 A0A8C0S370_CANLF PDZ domain-containing protein SNTG2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] structural molecule activity [GO:0005198] FTCYDSKTKNVLWR;LQSVRMANKCCSSCDQVVHM;TFMEVQRAGSR 3 8.8 0.851 0.14917 0 0 4.93381 0 0 0 0 0 0 8.66896 0 0 0 10.794 0 A0A8C0S380 A0A8C0S380_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] KRRVYFRNVSILIPLT;SGGSFTVS 2 3.1 0.98907 -0.21669 0 0 0 10.0154 0 10.1717 0 0 0 6.82439 0 0 0 0 0 A0A8C0S388 A0A8C0S388_CANLF Akirin-2 AKIRIN2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of innate immune response [GO:0045089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031] chromatin [GO:0000785]; nucleus [GO:0005634] transcription coregulator activity [GO:0003712] ICKKKKKKQ;KYLKQLKMLLTLLICKKKKKKQQ;LKQLKMLLTLLICKKKKKKQQ;QLKMLLTLLICKKKKKKQQK 4 9.2 1.0018 -0.66259 0 0 6.56499 0 0 0 3.84217 0 0 0 0 0 9.07644 0 0 A0A8C0S392 A0A8C0S392_CANLF Hexosyltransferase (EC 2.4.1.-) OBSL1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] ADGERAAAWPV;DDFDWFFI;GGEPAPGRYCHGGF;VEEPCGPG 4 5.5 1.0014 -0.69864 0 0 0 0 13.6081 0 0 0 0 0 0 7.97407 7.73193 0 0 A0A8C0S3A5 A0A8C0S3A5_CANLF Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122] cytoplasm [GO:0005737]; dendrite [GO:0030425] microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165] ARRPRRTEGATHR;SSCCCFCG 2 5.6 1.0043 -1.0447 0 5.25304 0 0 0 0 4.73091 0 0 0 0 0 0 0 0 A0A8C0S3B0 A0A8C0S3B0_CANLF Neuronal acetylcholine receptor subunit alpha-7 Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] LLVFLLPA;LVNSSGHC 2 5 1.0037 -1.1044 0 0 0 0 0 0 7.88277 0 0 0 0 0 0 0 0 A0A8C0S3D9 A0A8C0S3D9_CANLF C-type lectin domain-containing protein COLEC10 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] carbohydrate binding [GO:0030246] TECHLTMYFV 1 3.8 0.98543 -0.25957 0 0 9.78468 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S3F1 A0A8C0S3F1_CANLF Arrestin C-terminal-like domain-containing protein ARRDC2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GSHPGRDAVRQGEGV;GVAGSHPG;RGQGLGVAGS 3 4.8 1.0021 -1.2971 0 0 0 0 8.31913 0 0 9.26209 0 0 0 0 0 0 0 A0A8C0S3H1 A0A8C0S3H1_CANLF Microtubule-associated protein RP/EB family member 2 MAPRE2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] microtubule [GO:0005874] microtubule binding [GO:0008017] APMPGPTQTLSPNG;PAQQEGHPEEP;SHHANSPTAGAAKSSPASK;TAGAAKSS;VPFLGSAPMP;VSLNYTKVEQLC;YDPVEARQGQDAI 7 13.3 1.0032 -2.0882 0 0 10.7414 0 0 0 9.82356 10.003 8.0124 8.27459 11.1932 0 0 8.85904 0 A0A8C0S3H4 A0A8C0S3H4_CANLF Spt20-like SEP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] APAAASSSQRPP;ATPVTATS;GVFGYEGGREPQTT;GVSRLPTTTLSPASFSQSSPA;LEKLVRRES;LLRPTMQTLACDMQSITSDGQQW;SLSVACAANRLLYN 7 13 1.0019 -0.90924 0 6.97338 0 0 0 0 13.247 13.1931 10.5653 0 9.54767 0 0 0 13.2973 A0A8C0S3H5 A0A8C0S3H5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] plasma membrane [GO:0005886] FLVVIVPLVLLAGLAWCLWKR;KHSSLGGQDMVLHWERPHSMGLVFL;RPHSMGLVFLVVIVPLVLLAGLA 3 8.8 0.98969 -0.20135 3.41684 0 0 0 0 4.3584 0 0 0 0 0 0 0 0 12.9805 A0A8C0S3K6 A0A8C0S3K6_CANLF Src kinase-associated phosphoprotein 2 (Src family-associated phosphoprotein 2) SKAP2 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113] cytoplasm [GO:0005737] SLIKKIKDVKSTYLQEF;YGSDKDKQQKGEFA 2 9.3 0.99219 -0.20789 0 8.77873 0 0 0 0 0 0 0 0 0 0 0 0 5.53528 A0A8C0S3P0 A0A8C0S3P0_CANLF GTF2I repeat domain containing 1 GTF2IRD1 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] DNA binding [GO:0003677] ARHALPTGG;GPDRWNSAFTRKDE;ILEHSHRIR;LVSALDSMCSAL;MAILEHSHRIRFKL;SSSVASFLYST;VIINQLQPFTEICNDAKV 7 8.1 1.003 -1.3444 4.08466 0 0 0 9.69052 0 9.6307 0 0 12.4282 0 9.49649 0 9.24239 11.0443 A0A8C0S3Q3 A0A8C0S3Q3_CANLF MHC class I-like antigen recognition-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] DAFKFRRGPRPGC;QLAYQGSDLL;QLAYQGSDLLSFQNTSWRP 3 13.5 0.94275 0.059626 0 0 0 0 0 9.27942 0 0 0 0 0 0 0 0 0 A0A8C0S3R8 A0A8C0S3R8_CANLF Letm1 RBD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ribosome binding [GO:0043022] EDQLTLEHLDRPQLV;NVPPSLLLL;QPSKGTGTKIKEEKRSYRQ 3 9.8 1.0013 -0.9978 0 0 0 8.94556 0 0 0 0 0 9.06757 0 0 0 4.05762 0 A0A8C0S3S1 A0A8C0S3S1_CANLF Olfactory receptor LOC119867629 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LILKIFLIK;RRLILKIFLIKK;VISYGGCVAQL 3 7.3 1.0046 -1.0515 0 4.57247 0 0 0 0 0 0 8.14883 0 0 0 0 0 0 A0A8C0S3S6 A0A8C0S3S6_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] FTKILSLLRLLRLSRLIRY;GAGEEPAG;GVITKSSKEMKLTDGSYFGE;IMLIMMVG;IVRFTKILSLLRLLRL;LRIVRFTKILSLLRLLRLSRLIRYI;PGGGGAGA;PVGITFFT;VDYIFLIV;VLSPCSYTTAVCSPP 10 12 0.9969 -4.1584 0 7.64703 0 0 8.96573 8.68598 10.3004 0 13.3341 5.31861 0 3.78125 0 0 9.88105 A0A8C0S3T0 A0A8C0S3T0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AIIKAKKKKKKK;GRKTTDADFFRLTV;IIKAKKKKKKK;LHRLLLLGR;TAIIKAKKKKK;TAIIKAKKKKKKK 6 5.8 0.98529 -0.44853 2.53553 7.78509 5.97432 0 0 0 0 0 0 0 8.33181 0 0 9.785 0 A0A8C0S3U7 A0A8C0S3U7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;VVEELGEEPVQ 2 2.3 0.99076 -0.22104 0 0 0 0 0 9.66787 0 0 0 0 0 0 0 0 0 A0A8C0S3V4 A0A8C0S3V4_CANLF Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcitonin receptor activity [GO:0004948] AALLVNLFF;ESNRTWTNYTQC;HKNLFFSF;NGKSIHDIE;RTWDGWLCWN;SEHLNGKSIHDIEN 6 11.5 1.0016 -1.8193 0 0 0 0 0 6.68874 8.10014 7.37252 11.9764 0 0 7.55482 0 9.34236 0 A0A8C0S3V6 A0A8C0S3V6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EEDEEESEEEATDDSN;EEDEEESEEEATDDSNDYGE;EEESEEEATDDSNDYGE;RENSDDTEEEEEEEE;SEEDEEESEEEATDDSNDYGENGRQ;SEEEATDDSNDYGE;VLESELSLHQQTDCE 7 9.4 0.93374 0.06792 0 0 5.67692 0 0 5.85649 0 0 13.7878 0 0 6.94028 0 5.30159 6.63787 A0A8C0S3V9 A0A8C0S3V9_CANLF 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) PCBD2 Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrobiopterin biosynthetic process [GO:0006729] 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124] GWSELNERDAIYKEFSFKNFNQ 1 17.5 0.97527 0.046883 0 0 7.35279 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S3W8 A0A8C0S3W8_CANLF Arrestin C-terminal-like domain-containing protein ARRDC2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GVRSFALELARGP;PRPWEHRWGWDS 2 5.9 0.91552 0.1101 9.25094 0 0 0 0 0 0 0 7.45755 0 0 0 0 0 0 A0A8C0S408 A0A8C0S408_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 19 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AEDCEDYS;AEDCEDYSKCYV;EAGVWSEC;IMSGEWIKGQN;IQLNEDFIFIEPLNDTMAI;LTFKCLGDQWPVYCRVIR;MSTSWGEDMTSVDA;PCSRTCGK;RPREAEDCEDY;SQWTRPAAAGAA;YVRRGLWEKI 11 9.7 0.98551 -0.2354 0 0 12.0989 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S424 A0A8C0S424_CANLF SIR2-like domain-containing protein FAM118A Canis lupus familiaris (Dog) (Canis familiaris) DLATQICRQRSP;GNACQDCAK;MEIFDNLEQHIQN;VLHIHGLY 4 12.1 1.003 -1.723 0 0 0 0 0 7.0237 0 0 0 0 0 0 0 0 4.81665 A0A8C0S427 A0A8C0S427_CANLF Obscurin like cytoskeletal adaptor 1 OBSL1 Canis lupus familiaris (Dog) (Canis familiaris) DTVRRLVLPAV;GEFECRTEGVSAFFS;GVEGRWSRDGEDLP;HIPAADLTH;LCPGDKYELRS;LRRCGPLDAG;LSFPADGAEHG;RLRLQALGTRRLLQLRRCGPLD;SLDLSTIIQGTWF;TVRRLVLPAV;VAGDERAYFTV;VGAGAGAG;VTITDVSSW 13 7 1.0032 -2.3995 10.2371 9.75357 0 0 0 0 0 10.6547 0 3.48465 10.6994 10.6958 0 20.2442 8.12521 A0A8C0S428 A0A8C0S428_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] TISLDQYLRGK;VHLSRDTY 2 5.6 0.98525 -0.25334 0 0 0 0 0 0 10.4179 0 0 0 0 0 0 0 0 A0A8C0S437 A0A8C0S437_CANLF Transforming protein RhoA Canis lupus familiaris (Dog) (Canis familiaris) Rho protein signal transduction [GO:0007266]; stress fiber assembly [GO:0043149] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; lamellipodium [GO:0030027] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] EVDGKQVELALWDTAGREDHDHLRP 1 12.7 0.9749 0.035538 0 0 0 7.28568 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S446 A0A8C0S446_CANLF Protein FAM184A/B N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASGTCQGSKADVRGAAD;DSEDLAVAAEDGGGPG;DTETIRQAMQQ;GERRAGREPHVRILC;RDTETIRQAMQ 5 4.6 0.8072 0.21813 0 8.51991 9.58071 7.32589 0 0 0 0 0 0 0 0 0 13.2475 0 A0A8C0S448 A0A8C0S448_CANLF Striatin interacting protein 2 STRIP2 Canis lupus familiaris (Dog) (Canis familiaris) ALKVKQAMLQLYVL;FHYSYELWLEREVFSQPICWEELL;FPIKKVLLLLWKV;LEFTTNRRCFE;PIKKVLLLLWKVVMFTLG;QLYVLKLLKIQ 6 8.9 0.97611 0.048313 0 0 0 0 0 0 0 0 4.05198 0 6.88118 0 0 0 0 A0A8C0S471 A0A8C0S471_CANLF Anti-proliferative protein domain-containing protein BTG4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DSTSGISSDEESSN 1 7 0.93558 0.060864 0 0 0 0 0 0 0 0 0 0 8.28716 8.23764 0 0 0 A0A8C0S490 A0A8C0S490_CANLF OCA domain-containing protein POU2AF3 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; POU domain binding [GO:0070974] CYCASCETEH;NYNSPPSLDSRN;SASLSVQEPWEAP 3 12 0.78512 0.23293 0 0 0 0 0 0 0 0 11.2511 0 0 0 0 0 0 A0A8C0S499 A0A8C0S499_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVQSAAE;EVQLVQSAAEVKKPG;EVQLVQSAAEVKKPGA 3 15.8 0 5.6713 9.96896 9.21126 9.74621 10.5215 0 9.83903 10.2416 10.5898 0 0 11.0764 11.1973 9.5632 0 9.53829 A0A8C0S4A0 A0A8C0S4A0_CANLF CARD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737] CARD domain binding [GO:0050700] DQLKLKVSRLEEECSLL;IVSHVPVETGTD;LQYSQSLIEKDQYRKQ;PEHFTLLTGQ;SEPERSLKPYS;TLPERADP 6 5.4 1.0026 -1.8965 9.63039 7.08831 0 0 0 0 0 0 0 0 0 3.64189 0 3.73325 0 A0A8C0S4A1 A0A8C0S4A1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AARRKEGSGKPEA;DAELSDDASYECQATE;HESRYETNVDYSFFTEPV;IELDVHHPPTV;MDTREEYEMKDP;NLTCRAFNAKPAATI 6 9.6 0.99265 -0.2829 9.95828 0 0 10.4916 0 0 10.1421 0 0 0 0 8.06593 0 0 11.0677 A0A8C0S4A8 A0A8C0S4A8_CANLF Thiamine diphosphokinase TPK1 Canis lupus familiaris (Dog) (Canis familiaris) thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] ATP binding [GO:0005524]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788] AGEKPPAEAPGEPAG;QPLDKCVRHLWSKALLR 2 7.8 0.99396 -0.13244 0 0 0 0 0 0 0 0 0 0 10.223 5.01042 0 0 0 A0A8C0S4C3 A0A8C0S4C3_CANLF TGF-beta propeptide domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] VRGHGGGV 1 2 1.0041 -1.1044 10.9536 10.9343 0 0 0 0 11.5353 11.4259 11.5758 0 0 11.1741 0 0 0 A0A8C0S4F6 A0A8C0S4F6_CANLF Vascular permeability factor VEGFA Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of cell division [GO:0051781] membrane [GO:0016020] growth factor activity [GO:0008083]; heparin binding [GO:0008201] IPCSLFCPQWSQA;QKRKRKKSRYKPW 2 13.3 0.98313 -0.25593 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.71321 A0A8C0S4H5 A0A8C0S4H5_CANLF PHD-type domain-containing protein G2E3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] ESYYLNFISAISRSKLED;MKSNPETDDYRY;MLNFNVPHVKNS;YPEAFYSIFCHKPEN 4 4.5 0.99263 0.0045046 0 0 8.33195 0 7.98721 0 9.24703 0 0 7.64386 0 0 0 0 0 A0A8C0S4I4 A0A8C0S4I4_CANLF Kallikrein B1 KLKB1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] CTFHPRCL;EGEELNVTFAEGVN;FEGEELNVTFAEGVN;FSLKSCALSEIGCHM;MYTPNAHHCQMMCTF;SSIKVLADVVSGFSL;TFYTKAWNVCFLKTS;VEYRNSCLLKNGPG 8 17.9 0.95227 0.053903 0 0 0 0 0 0 0 0 0 0 3.82293 0 0 0 0 A0A8C0S4J7 A0A8C0S4J7_CANLF WD repeat domain 36 WDR36 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] small-subunit processome [GO:0032040] GHGLINKKKVKRKGLQ;KFAAEEARESDWDSIIAC;KILIHSVSLSSSPN;NIKSNKLLYTFQG;SASMDCSV;SSGTVDVYNMQSG;SVRLPPITKFAAEEARES;SVRTWDLPSGCLIDSF;SVRTWDLPSGCLIDSFL 9 11.8 1.0032 -1.9149 12.6984 9.36267 0 0 0 7.68538 0 0 6.68018 0 5.94881 0 0 11.737 11.1451 A0A8C0S4J9 A0A8C0S4J9_CANLF Sushi domain containing 4 SUSD4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of complement activation [GO:0030449] membrane [GO:0016020] ATSVLLVL;DLQTSFPV;SLGIDITDGEYLPPAPS;VISYHCFPGFKL 4 10.4 1.0032 -2.3746 11.3646 11.3449 9.77418 0 9.45615 0 11.6134 11.1967 0 0 3.12352 7.13114 0 0 0 A0A8C0S4K4 A0A8C0S4K4_CANLF CAP-Gly domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEKKMLDH;AVSRKTHDASGQLV;EDALRDALDQAQ;EIGELKAVMEGIKME;HSNMIESND;QKLQEAQEEAGL;SSVSSVASSVGGRPSRSG;VGETDFAKG;VIPLRESVLNSSVKTGNES 9 11.5 1.0014 -2.6649 6.29447 0 0 8.12221 8.46928 0 8.80355 0 0 9.2475 7.85649 0 0 0 0 A0A8C0S4K6 A0A8C0S4K6_CANLF Nardilysin convertase NRDC Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AEIEDDDEEGFDEEEEFDDDDE;ARWSMIDKYRA;DDDDDDEDEDSGAEIEDDDEEG;DDDDDEDE;DDEEEEEEEEEEDDD;DDEEGFDEEEEFDDDD;DEEEEFDDDDEHDDDD;DEEEEFDDDDEHDDDDL;EDDDDDDD;EDDDDDDDEDEDSG;EDDDEEGFDEEEEFDDDDEH;EEEDDDDDDDEDE;EEEDDDDDDDEDED;EEEEEDDDD;EEEEEDDDDDDD;EEEEEDDDDDDDEDEDSG;EEEEEDDDDDDDEDEDSGAEIED;EEEEEEDDDDD;EEEEEEDDDDDDD;EEEEEEEDDDDDDDEDEDS;EEEEEEEEDDDDDDDED;EEEEEEEEEDDDDDDDED;EEEEEEEEEDDDDDDDEDED;EEEEEEEEEDDDDDDDEDEDSG;EEEEEEEEEEDDDDDDDED;EEEEFDDDDEHDDDDL;FDDDDEHDDDDLDTEDN;GAEIEDDDEE;GAEIEDDDEEGFDEEEEFD;IEDDDEEGFDEE;LDRWAQFFIHP;LGEEVDRNWNEVV;NVVLFDIFVNILTHNLAEP;VAGEHGLI 34 10.4 1.0033 -2.107 7.00124 8.36207 10.2131 4.63564 8.21364 5.29917 9.68017 9.31967 7.23707 7.43912 9.65737 9.83643 9.82319 8.69502 6.5505 A0A8C0S4N4 A0A8C0S4N4_CANLF HTH psq-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] PSALLVHG 1 5 1.0042 -1.1044 0 0 0 0 0 7.03837 8.2571 0 0 0 0 0 0 0 0 A0A8C0S4P9 A0A8C0S4P9_CANLF Olfactory receptor family 10 subfamily D member 1K OR10D1K Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FYHFLGCTECFLYTVMAYDR;QVLNNLVTP;VKSSLRKVL 3 12.1 1.0038 -0.80421 11.2784 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S4Q1 A0A8C0S4Q1_CANLF Transcription initiation factor TFIID subunit TAF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] AKPPDLYDT;DDEEDAGSDEEGDNP;DEDDYDADCEDI;DEDDYDADCEDIDC;EDDEEDAGSDEEGDNPFS;HSDYDEDDYDADC;HSDYDEDDYDADCE;KEDKLARLEKAI;NYYKRKPG;PLCHSDYDEDDYDADC;PVESKFSQ;QPLCHSDYDEDDYDADC;QPLCHSDYDEDDYDADCE;SQVHLSEDEEDSEDFHSIAGD;VLSQVHLSEDEED;VLYEDLLMSEGEDDEEDAG 16 5.9 1.0026 -1.7834 4.9953 7.93422 11.8594 11.6083 6.54801 11.7756 9.09468 0 0 3.74814 0 11.7954 9.108 11.9635 12.1908 A0A8C0S4R0 A0A8C0S4R0_CANLF Cellular communication network factor 6 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] GEVCCRPAEPAERRGRPLCRW;LLTDGCGCCEVCARQ;RPAEPAERRGRPLCRWPCE;TDGCGCCE 4 11.8 0.97849 0.047674 0 7.26716 0 0 0 0 0 0 6.04527 0 0 0 0 0 0 A0A8C0S4R9 A0A8C0S4R9_CANLF Immunoglobulin superfamily member 9B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ANHSFPIDRYIMEYRVGE;FSVWMKRAQF;INAPPTFTETPPQYIEA;LHPCDVAESLQ;PFHHGQYYGYLSSSS;PIELISRGPDGRFVMDP 6 6.5 0.98657 -0.41836 4.49589 0 0 0 0 0 0 0 0 0 7.32598 10.9908 8.89276 0 6.81263 A0A8C0S4S3 A0A8C0S4S3_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAPVGRRRRRRRRRRRR;GGGGGGGG;GGGGGGSG;GGRGGGGG;QPVPGYLDMPVVP;VGRRRRRRRRRRRRSGR 6 12 0.98803 -0.49577 0 0 0 0 7.4154 0 0 9.83564 5.33928 0 0 0 0 0 0 A0A8C0S4T5 A0A8C0S4T5_CANLF Thymic stromal lymphopoietin TSLP Canis lupus familiaris (Dog) (Canis familiaris) cytokine activity [GO:0005125] DGTRSTEFSHPVY 1 12.6 0.98464 -0.24698 0 0 10.4018 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S4U0 A0A8C0S4U0_CANLF Core histone macro-H2A MACROH2A1 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] DIDLKDDLGN;TIASGGVL;VLELRKKNGPL 3 7.8 0.9864 -0.42704 0 6.69905 0 0 0 0 0 16.085 0 0 0 0 10.8379 0 0 A0A8C0S4U8 A0A8C0S4U8_CANLF Zinc finger protein 354A ZNF354A Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEWRKLGPSQ;IHAGENPHKYN;KCKECSKAFNQSSALIQHQITHTG 3 7.5 0.98934 -0.50891 6.34525 0 0 0 0 10.3463 0 0 0 0 0 0 0 0 0 A0A8C0S4V1 A0A8C0S4V1_CANLF UDP-galactose translocator SLC35A2 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150] TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] protein transmembrane transporter activity [GO:0008320] GPSPFCPVLLAFTSFSLPFHS;IVDDCGGAFTMGVIGGGVF 2 21.6 0.99084 -0.19442 0 0 0 0 0 0 0 10.6192 0 0 0 0 0 5.70877 0 A0A8C0S4V5 A0A8C0S4V5_CANLF Nucleoside diphosphate kinase (EC 2.7.4.6) NME4 Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] GTIRGDFSVHISRN;LQAPERVLAEHYHDL 2 15.5 0.91918 0.11501 0 0 8.82817 0 0 0 0 0 0 0 0 0 0 0 6.95152 A0A8C0S4W9 A0A8C0S4W9_CANLF Origin recognition complex subunit 3 ORC3 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nuclear origin of replication recognition complex [GO:0005664] DNA binding [GO:0003677] ELMTILQK;LDKLSLLEHFYSQPLSV;LGSTAKRIEEFLA;QLMMDCCVDEE 4 7.3 0.97971 0.046227 0 0 0 0 12.8247 0 0 0 0 0 0 0 0 0 0 A0A8C0S4X2 A0A8C0S4X2_CANLF "TLE family member 6, subcortical maternal complex member" TLE6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] FLRTMEIWSGPPGFQ;TLAPELNYHSVLG;TLAPELNYHSVLGQ;VGTDDLLGIYGMP 4 7.2 0 1.3489 9.27919 9.69891 9.44582 8.38763 0 8.9394 9.81726 10.6492 0 10.0761 13.3086 13.0794 9.48605 8.6818 9.21184 A0A8C0S4X9 A0A8C0S4X9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;LVESGGDLVK;LVESGGDLVKPG;QLVESGGDLVKPG;SGGDLVKPG;VESGGDLVKPG;VQLVESGGDLVKPG;VTFSSYEMTWVRQVPEK 15 22.1 0.98086 0.046227 0 0 0 5.36803 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S4Y2 A0A8C0S4Y2_CANLF Hexosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] DRDEVIEWEFLMGKLLYSASENQP;FNHFQPRDRDEVIEWEFLMGKLLYS;GRSAAGPGAGAQQPLPQPQPRPRP;KVTNGGNP;MHDHYLDKYEWFMRAD;QLFSKPFFRETEELDVN;YEWFMRADDDVYIKG 7 11.7 1.0019 -1.4687 0 6.84071 0 0 8.5575 0 0 0 9.24802 0 0 0 10.2955 0 0 A0A8C0S4Z2 A0A8C0S4Z2_CANLF "Zyg-11 family member B, cell cycle regulator" Canis lupus familiaris (Dog) (Canis familiaris) Cul2-RING ubiquitin ligase complex [GO:0031462] ENNIAEVQE;ETNLLAFVFPLCFF;IVRQLLQIVKQK;LCSDRILQDVPFNRF;LKAMEHFPNHQQLQ;LSTEQTAQLGA;PTPECEMVAYRSFNPFF;SKEEASPYSLLDICLNFLTTH;TTQILDVVRE 9 16.5 1.0021 -1.1355 9.64173 10.7903 0 11.4166 10.3975 4.69972 0 10.0456 0 5.11794 0 10.6082 0 0 0 A0A8C0S4Z6 A0A8C0S4Z6_CANLF Tachykinin 3 TAC3 Canis lupus familiaris (Dog) (Canis familiaris) tachykinin receptor signaling pathway [GO:0007217] extracellular region [GO:0005576]; membrane [GO:0016020] PLPSSHPG 1 3.1 1.0039 -1.1044 0 0 0 6.45909 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S500 A0A8C0S500_CANLF "Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VEELIGQLEQQAL;VGAGAGAG;VPIPVYRPP 3 9.5 0.9843 -0.24018 0 0 0 0 0 0 0 9.031 0 0 0 0 0 0 0 A0A8C0S505 A0A8C0S505_CANLF Tubulin alpha chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] DVVPKDVNAAIA;GDVVPKDVNAAIA;THTTLEHSDC;VGESMEEGEFSEACEDM 4 10.9 0.98245 0.046227 0 0 0 0 1.71616 0 0 0 0 0 0 0 0 0 0 A0A8C0S543 A0A8C0S543_CANLF Solute carrier family 25 member 46 SLC25A46 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane fission [GO:0090149] mitochondrial outer membrane [GO:0005741] AASLCSDVILYPLE;HYHLTPFT;LHGVLHYIIS;LILKRKTY;PSPFPPPILCPPSSAPRPLPSPL;RPSLFPLRPLLVP 6 11.4 0.92781 0.106 0 8.26379 0 0 0 0 0 0 0 0 4.8302 0 0 0 0 A0A8C0S547 A0A8C0S547_CANLF Olfactory receptor OR2A13 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGLFFAMMVYLV 1 3.9 0.95013 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.77156 0 A0A8C0S559 A0A8C0S559_CANLF Transcription and mRNA export factor ENY2 Canis lupus familiaris (Dog) (Canis familiaris) poly(A)+ mRNA export from nucleus [GO:0016973]; regulation of transcription by RNA polymerase II [GO:0006357] DUBm complex [GO:0071819]; nuclear pore [GO:0005643]; SAGA complex [GO:0000124] chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713] KKRKRKILN;LFKKRKRK;LYFNFLKT 3 22.1 1.0027 -2.5737 0 0 0 0 0 5.28947 0 0 0 0 0 0 6.2683 0 0 A0A8C0S567 A0A8C0S567_CANLF Zinc finger protein 556 ZNF556 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LNRSHMVERLC;PINASNVERPSDGPHPSK 2 6.4 0.98796 -0.47733 8.47642 0 10.3776 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S568 A0A8C0S568_CANLF Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) ICMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] endoplasmic reticulum membrane [GO:0005789] protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671] KKKTKNKKRKLWLLSP;LLKKKTKNKKRKL;PAGGGGGA 3 5.5 0.94343 0.059561 6.56056 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S570 A0A8C0S570_CANLF Rho guanine nucleotide exchange factor 5/35 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LDVPPGPQPWADQQTLW;LMCLLDAWGLE;LVASEVSSPCDLFPDTCYP 3 8.6 0.98245 0.046227 0 0 9.2148 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S574 A0A8C0S574_CANLF NMDA receptor synaptonuclear signaling and neuronal migration factor NSMF Canis lupus familiaris (Dog) (Canis familiaris) regulation of neuron migration [GO:2001222]; regulation of neuronal synaptic plasticity [GO:0048168] DPTPMKADTSHDSRDSSDLQ;HPHHHSQPL;LLADAYSGHDGSPEMQPA;QVVQLVTSTHTHPGPGAQVGGGW;WSDPTPMKAD 5 10.9 1.0016 -0.75159 0 0 0 9.13075 0 0 0 0 0 5.31248 0 0 0 9.42633 0 A0A8C0S580 A0A8C0S580_CANLF Olfactory receptor family 10 subfamily G member 9C OR10G9C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IDMWFSTVT;PKMLMTFGSPG;TFGSPGGRMISFHS;VVYTLRNKEVKKALLKL 4 14.5 1.0016 -1.2573 0 6.91851 0 0 0 0 7.25162 0 0 0 0 0 0 0 0 A0A8C0S590 A0A8C0S590_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LDPDSTLLTGMKVEQSPSALS 1 12.9 0.9562 0.051544 0 0 0 0 0 0 0 9.42185 0 0 0 0 0 0 0 A0A8C0S591 A0A8C0S591_CANLF SCAN box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DFRVEENEEVILC;EYYYFDKTMCECFDSDQFL;KTMCECFDSDQFL;QEYPRLCAPATCYTSVHTDK 4 6.5 0.99585 -0.092692 0 0 0 6.68103 4.02352 0 0 0 9.03428 0 11.39 0 0 0 0 A0A8C0S5A4 A0A8C0S5A4_CANLF RGS domain-containing protein AXIN1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoplasm [GO:0005737] GYALAPATSANDSEQQSLSSDA;KDCIVKQLIDPAMFDQAQ;LSLTDSSVW;SGRDPAPPGRLTQKLL;SHSESVGAAPN;VGCVGLRDAHEENP 6 9.1 0.85638 0.16749 12.5446 11.7778 11.0773 9.5566 0 0 11.0366 11.021 0 0 10.5897 10.5848 10.0724 11.2254 8.14226 A0A8C0S5B7 A0A8C0S5B7_CANLF Egl-9 family hypoxia inducible factor 2 EGLN2 Canis lupus familiaris (Dog) (Canis familiaris) GMGCSSGN 1 2.1 1.0041 -1.1044 0 0 0 5.83292 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S5C1 A0A8C0S5C1_CANLF Unconventional myosin-Ia (Brush border myosin I) (Myosin I heavy chain) TAC3 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DNGIICNLIEHNQRGI;GVVSDSTFLAKLNQLFSKH;LRDRDRDQ;PAAPYRYFHTANQEL;QLPIYGPEFIAKYQD;SLHLSEISSVGSKGDF;VTEKWCAVRGQWPV;VVTALNVI 8 10.9 1.0019 -1.2609 0 0 9.47007 0 7.22863 0 0 0 9.63365 9.76592 9.53648 0 0 9.95595 9.13532 A0A8C0S5G4 A0A8C0S5G4_CANLF Tribbles homolog 2 TRIB2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436] cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634] ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein kinase inhibitor activity [GO:0004860] TEIILGETK 1 3.4 0.99394 -0.15584 0 0 0 0 0 0 0 9.03672 0 0 0 0 0 0 0 A0A8C0S5J8 A0A8C0S5J8_CANLF Inhibin alpha chain INHA Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083]; hormone activity [GO:0005179] HMRSRQVTSAHLWFHTGL;HYCHGGCG;LLLLLLLL;LLLLLLLLL;LLLLLSPD;LVPSSGVP 6 12.5 0.99922 -2.9229 0 0 5.68299 0 0 0 10.0681 3.73357 0 0 0 0 0 0 0 A0A8C0S5L5 A0A8C0S5L5_CANLF Family with sequence similarity 160 member A1 Canis lupus familiaris (Dog) (Canis familiaris) AHTNILRCMRDCRV;CMRDCRVWSALYDGD;DETKMEQLK;ESASLWCLVPCGRG;MIVFKNHWAQVV;PEEEEDDFDSFIAETPTAD;VLRYLIPCNHMMLSQ 7 9.1 1.003 -0.97607 0 0 3.58964 0 0 10.3945 0 0 0 0 0 0 0 0 4.57489 A0A8C0S5P3 A0A8C0S5P3_CANLF Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.53) (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (mRNA N(6)-methyladenosine demethylase FTO) (tRNA N1-methyl adenine demethylase FTO) FTO Canis lupus familiaris (Dog) (Canis familiaris) DNA alkylation repair [GO:0006307]; regulation of multicellular organism growth [GO:0040014]; RNA repair [GO:0042245] cytoplasm [GO:0005737]; nuclear speck [GO:0016607] broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931] DDEFYQQWQL;IVSELRGFRDGRC;VLHEVRREGVPVEQRNE 3 7.9 0.98543 -0.44644 0 0 0 0 0 0 10.9091 0 0 0 0 0 0 10.7406 0 A0A8C0S5P9 A0A8C0S5P9_CANLF Ly-6/neurotoxin-like protein 1 LOC119864752 Canis lupus familiaris (Dog) (Canis familiaris) dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] acetylcholine receptor inhibitor activity [GO:0030550] TTSCCQYDLCNGAGL 1 12.9 0.98737 -0.2253 0 0 0 0 10.1601 0 0 0 0 0 0 0 0 0 0 A0A8C0S5Q6 A0A8C0S5Q6_CANLF DUF3719 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GARGSGGA;LVAECSEWARRS;SPTPAGAHSSWPG 3 4.4 0.98973 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.35184 A0A8C0S5R0 A0A8C0S5R0_CANLF DUF3719 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LVAECSEWARRS;PSPAAACSPAGGAAAAGRAGWG;SPTPAGAHSSWPG 3 6.5 0.99124 -0.13493 0 7.98299 8.00023 0 0 0 0 0 0 0 0 0 8.19328 7.90105 0 A0A8C0S5R2 A0A8C0S5R2_CANLF RecA family profile 1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; reciprocal meiotic recombination [GO:0007131]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; membrane [GO:0016020]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; four-way junction DNA binding [GO:0000400]; single-stranded DNA binding [GO:0003697] QEMVDIGTWGPPEQS;SALCCFPAPATQSV 2 6.2 0.94223 0.0611 8.9216 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S5U2 A0A8C0S5U2_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EGPKDFEFAK;KPNSSHDIQLSG;LNSDMSKCENDD;LTIQVTCAFEQLVVLIKHW;VTCAFEQLVVLI;YESNNSNKSEDVFCDPEDE 6 4.6 1.0022 -0.68761 0 0 8.71754 5.62545 0 0 0 2.87737 8.55109 0 11.6416 0 0 0 0 A0A8C0S5U4 A0A8C0S5U4_CANLF Laminin subunit alpha 4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] ADNLTNWSQNLQ;CAVCNCGG;DIYIGGAPPEILQSRT;EEHELTSEEISE;EGGFNFRTLQ;IFYVSDQEE;IKVQSADKQYNDG;LPPTGAAWNIKGPIYLGGVAPG;LVHGHSVNGEYLNVHMKK;MFFVNKSSCIC;NAKLSDLQESL;PGRAVKNV;SEGNAPRDAYCHLS;VHLEDTSKRAQINDAKYHEISI;VYNLGTKD 15 10.3 0.99667 -4.7834 11.1248 0 0 9.29678 0 0 10.8324 8.41105 12.0351 10.9871 0 9.51047 0 8.82413 9.15879 A0A8C0S5U5 A0A8C0S5U5_CANLF Ankyrin repeat domain 42 ANKRD42 Canis lupus familiaris (Dog) (Canis familiaris) NF-kappaB binding [GO:0051059] LVSDSKWAF;TQALKAFNDNGENV 2 4.1 1.0016 -0.74308 0 0 0 0 0 0 7.94936 0 10.9733 0 0 0 0 0 0 A0A8C0S5U9 A0A8C0S5U9_CANLF NAD-dependent protein deacetylase sirtuin-2 (NAD-dependent protein defatty-acylase sirtuin-2) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) SIRT2 Canis lupus familiaris (Dog) (Canis familiaris) myelin sheath [GO:0043209] metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; transferase activity [GO:0016740] LVGAGISTSAGIPDFRSPSTG 1 9 0.94779 0.054578 0 0 0 0 0 0 0 0 0 0 0 0 9.18284 0 0 A0A8C0S5W3 A0A8C0S5W3_CANLF KIAA0930 Canis lupus familiaris (Dog) (Canis familiaris) AARMAQKMSFGFYKYNNMEFVR;LGPTGGWAP 2 6.2 0.98861 -0.21799 0 0 0 0 0 0 0 7.78529 0 0 0 0 0 0 0 A0A8C0S5X8 A0A8C0S5X8_CANLF Calcium binding protein 39 like CAB39L Canis lupus familiaris (Dog) (Canis familiaris) EDYEKLLLSENYVTKR 1 4.9 0.95605 0.049233 0 0 0 0 5.56739 0 0 0 0 0 0 0 0 0 0 A0A8C0S5Y6 A0A8C0S5Y6_CANLF Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) SIKE1 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] ESLQVRKENSMDTASQAIK;SQENTQIRDLQQ 2 15 0.98969 -0.21944 0 0 0 0 0 0 8.6355 0 0 0 0 0 0 0 0 A0A8C0S5Z3 A0A8C0S5Z3_CANLF Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; exocytosis [GO:0006887]; protein homooligomerization [GO:0051260] axon [GO:0030424]; dendrite membrane [GO:0032590]; lateral plasma membrane [GO:0016328]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] APLPTRTEGVIDMR;EKNHFESSPL;LPELQSLDEFG;QIFRIMRILRILKL;VLVIALPIPIIVN;YSLDDNEYFFD 6 8.5 0.98851 -0.31939 0 0 0 0 5.03038 4.94341 11.9711 10.5007 0 9.52188 0 9.16955 0 0 0 A0A8C0S604 A0A8C0S604_CANLF Nucleoporin 50 NUP50 Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907]; mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear pore [GO:0005643] AGGKPLEGLSNGSSI;EERQGAVSGPRNWFDCSP;ESETNKMPLATQS;SSGLTSSA 4 10.7 1.0016 -0.96262 10.7791 0 0 0 0 12.397 0 0 13.0639 10.8038 0 10.2086 12.1216 10.9638 0 A0A8C0S614 A0A8C0S614_CANLF TIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] FNPFDCTC;PVMLFDIS;REELDFLGNS;THNQLRRLPP;VLLTFIFIVLLIHFEGW 5 5.9 1.0021 -1.292 0 0 12.3259 0 8.84486 0 0 0 0 0 0 0 0 4.88308 0 A0A8C0S622 A0A8C0S622_CANLF WH2 domain-containing protein LMOD2 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] sarcomere [GO:0030017] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] DEEDEEDEEHEEH;DIEPDHSLPV;EEVYTEEEDEEDEEDEEHEEHEG;EVYTEEEDEEDEED;KKKKGKKVKKQPNN;NSEVSEEVYTEEEDEEDEED;VYTEEEDEEDE 7 9.1 0.97817 0.046253 0 0 0 0 0 5.79971 0 0 0 0 0 0 0 0 0 A0A8C0S625 A0A8C0S625_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] GVRAALPEP;VLGLPWKTTERDLREYFST 2 11.4 1.0035 -1.036 0 0 10.7842 0 0 0 0 0 0 0 0 5.0054 0 10.5776 0 A0A8C0S626 A0A8C0S626_CANLF UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) OGT Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] protein O-acetylglucosaminyltransferase activity [GO:0097363] EKLAYMPHT 1 0.9 0.99275 -0.27149 0 0 0 0 0 0 0 0 0 0 0 0 0 9.42633 0 A0A8C0S634 A0A8C0S634_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;LVESGGDLVK;LVESGGDLVKPG;QLVESGGDLVKPG;SGGDLVKPG;VESGGDLVKPG;VGVQCEVQLVESGGDLVKPG;VQLVESGGDLVKPG;VRQAPGKGLQ 16 25.2 0.95393 0.052207 0 0 10.4657 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S646 A0A8C0S646_CANLF RNA binding protein fox-1 homolog Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] RYAQPTPATAAAYSDRNQF;VEIEDRKVSRQQMNCERE;VSGTATQFGKI 3 12.6 0.99251 -0.17075 0 0 0 10.357 0 0 0 0 0 0 7.36851 0 10.9771 0 0 A0A8C0S661 A0A8C0S661_CANLF Serine/threonine-protein kinase (EC 2.7.11.1) PIM2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; G1/S transition of mitotic cell cycle [GO:0000082]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of macroautophagy [GO:0016239]; protein stabilization [GO:0050821]; response to virus [GO:0009615] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] CPLEVALLWKVGA;SPLSDSVTCPLEVALL;VGAGGGHP 3 8.4 0.98773 -0.37277 0 0 0 0 10.6669 0 0 0 0 0 0 0 9.5265 0 8.09355 A0A8C0S667 A0A8C0S667_CANLF Phosphatidylinositol-specific phospholipase C X domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] phosphoric diester hydrolase activity [GO:0008081] RGQQVIVSYEEASVV 1 4.7 0.95397 0.053903 0 0 0 0 0 0 9.88839 0 0 0 0 0 0 0 0 A0A8C0S686 A0A8C0S686_CANLF NGFI-A binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] transcription coregulator activity [GO:0003712] PLHVRRLQKALRE;PPPPGPASRRRSAAAPAPRPGG;SHSELQQPPPG;SPGEKAGSARSFSP 4 9.5 0.99297 -0.053055 0 7.52356 0 0 0 0 0 11.99 0 11.0562 0 4.66715 0 0 0 A0A8C0S6A0 A0A8C0S6A0_CANLF Cannabinoid receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222] axon [GO:0030424]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynapse [GO:0098793] cannabinoid receptor activity [GO:0004949] DAYASSTCCTCRDCVL;DIRLAKTLVLILVVLII;GVTSVLLL;IRLAKTLVLILVVLIICWGPLLAI;LGWNCKKLQSVCSDIFPLIDETYL;NAQLVPADQVNIT;TLVLILVV;VNITEFYNKSL 8 18.8 0.99884 -2.9772 10.3663 0 5.60632 0 0 0 0 0 0 0 0 0 0 6.57243 0 A0A8C0S6C6 A0A8C0S6C6_CANLF Eukaryotic translation initiation factor 1 (Protein translation factor SUI1 homolog) EIF1 Canis lupus familiaris (Dog) (Canis familiaris) eukaryotic 43S preinitiation complex [GO:0016282] ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] EHPEYGEVIQLQGDQRKNICQFLV;STEEKESYRMSA 2 17.1 0.98797 -0.22441 0 0 0 9.82311 6.68874 0 0 0 0 0 0 0 0 0 0 A0A8C0S6E4 A0A8C0S6E4_CANLF Glutathione peroxidase GPX5 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] extracellular region [GO:0005576] glutathione peroxidase activity [GO:0004602] LLVSFVQTNAKPEK;VFTFLKLSCPHPSEVL 2 13.6 0.99111 -0.26994 0 0 0 0 0 0 0 0 11.4649 0 0 0 0 0 0 A0A8C0S6E5 A0A8C0S6E5_CANLF EF-hand domain-containing protein MYL10 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] calcium ion binding [GO:0005509] AEGGASSNVFSMFD;DLWRKGSCSTP;PQPPASAY 3 11.8 1.0028 -1.5862 0 0 0 0 0 0 0 0 8.61996 9.4329 0 0 0 0 0 A0A8C0S6F5 A0A8C0S6F5_CANLF Ubinuclein 2 UBN2 Canis lupus familiaris (Dog) (Canis familiaris) ARAKKKVIPAPKPK;LACSSPLIKNSDK;TAHSSSLIAGHTGPVP 3 3.3 0.99064 -0.26822 0 0 0 0 0 0 0 0 0 10.5291 0 0 0 0 0 A0A8C0S6J6 A0A8C0S6J6_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SOHLH2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; neuron projection morphogenesis [GO:0048812] ATP binding [GO:0005524]; protein dimerization activity [GO:0046983]; protein kinase activity [GO:0004672] ELITMMLLV;KTYFSNTVKNEYSMKPEEPGLP;LVEGESYVCG;LVYEHQDGSKSL;MDENDGPGE;SIMSFGRDMELEH;SPTSPGSLRKQRSSQHGGSSTSLAS;TASILEAT;VLFDQILMGQVDF;YRNGDRYFKGIVYAISPDRFRSF 10 16.5 1.0019 -1.2104 0 0 0 9.98342 5.14678 8.01631 13.3454 0 11.6894 0 8.96924 0 6.73904 0 9.33468 A0A8C0S6M2 A0A8C0S6M2_CANLF Ig-like domain-containing protein OPCML Canis lupus familiaris (Dog) (Canis familiaris) GLAGDFSGP;RGFALPAD;VHLIVQVPPQIMN 3 6.6 1.0027 -1.0104 0 12.8289 0 0 0 4.88274 0 0 0 0 0 0 0 0 8.76427 A0A8C0S6N0 A0A8C0S6N0_CANLF Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) BAG6 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; immune system process [GO:0002376]; spermatogenesis [GO:0007283] extracellular region [GO:0005576]; nucleus [GO:0005634] IFEPGADGALGFF;PPAPEGGGG;PTSTTVESSTEGAPPP;PVVMMHMNIQ;VGAQMNVKE;VGPDAILRYVRRVG;VLGTAATTDYNNNQ 7 7.9 1.0023 -1.8435 9.82163 0 0 0 0 0 0 0 7.68229 9.84216 0 0 5.18674 0 0 A0A8C0S6N2 A0A8C0S6N2_CANLF TAR DNA-binding protein 43 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] GVRAALPEP;NYPKDNKRKMDETDLR 2 10.5 0.95911 0.049233 0 0 0 0 7.34678 0 0 0 0 0 0 0 0 0 0 A0A8C0S6P3 A0A8C0S6P3_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936] cytosol [GO:0005829]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EDQNGMYCFCLGPCLD 1 4.1 0.9586 0.049233 0 0 0 4.29499 0 0 0 0 0 0 4.61536 0 0 0 0 A0A8C0S6Q0 A0A8C0S6Q0_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme A) OTUD5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; proteolysis [GO:0006508]; response to lipopolysaccharide [GO:0032496] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578] EQQEHWFEKALRDKKGFIIKQMKED;ESYLQWLRDQE;GAVGVGGC;LVSLYPALECRALIQ;PRQRSSASSPEH 5 12.4 1.0022 -1.441 0 10.3501 0 0 0 0 0 0 0 0 0 0 8.99625 9.80552 8.39596 A0A8C0S6Q8 A0A8C0S6Q8_CANLF MIF4G domain-containing protein PAIP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EDLIVSTTENTHESTI;ISPQSGNFRQ;KPQVVVAP;YTDSYEDGCEDY 4 11.3 1.0021 -1.8293 8.38461 0 0 0 0 0 0 0 0 10.295 0 8.37547 6.9384 0 0 A0A8C0S6S3 A0A8C0S6S3_CANLF NBAS subunit of NRZ tethering complex Canis lupus familiaris (Dog) (Canis familiaris) "protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783] AKNKKEKKIKKRRELLKL;DEGEEDSDSDQEVSAKARYFGY;ESCGCADF;ETRGGDEDEGE;FETLKTDPEAFHKHMVKYIY;GVKILPLQVRLRGDRIS;IKPETHIRLLKKFKVV;LFTYHGSDLLP;LGLAETLEESVY;LPQVLDANK;LSIWAIPS;LVSLKNSEQEIL;MMHCSACS;VISSNPWVR;VISSNPWVRLATVMLTRC 15 7.9 0.79058 0.22246 0 0 0 11.2897 10.144 0 0 12.5247 0 0 0 0 0 0 0 A0A8C0S6S5 A0A8C0S6S5_CANLF Guanine nucleotide-binding protein subunit gamma Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] heterotrimeric G-protein complex [GO:0005834] G-protein beta-subunit binding [GO:0031681] EQLRIEAGIERIKVSKASSELMS;PLLRRVVARHELFQR 2 13.6 0.95091 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.29414 A0A8C0S6S9 A0A8C0S6S9_CANLF NuBaID C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PEDLKTMAERSPG 1 5.7 0.93764 0.059742 0 0 0 0 0 6.02363 0 0 0 0 7.19643 0 0 0 0 A0A8C0S6T4 A0A8C0S6T4_CANLF Interleukin 2 receptor subunit beta IL2RB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] ADVGTHKCNITW;DPCAEEPQ;EATTCDRDRLTCK;GGWGWSRGSTFASVLA;HFTPGPGNIQ;LEFEARKRSPGHSWEEASL;RLTCKARNIYSL;SFLGGSSGSHAFALGGSLPPT 8 16.6 1.0027 -1.8516 6.92647 0 9.6249 0 0 11.7461 9.91416 10.8597 10.7497 0 0 0 0 0 8.86576 A0A8C0S6U2 A0A8C0S6U2_CANLF Transporter Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] IYYNMIIAYVL;PALGPPARTENICPSTLPKPHGLFQ 2 4.7 0.9957 -0.56672 0 11.7909 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S6U9 A0A8C0S6U9_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LPRLPRLPRLRRRRSSP;PRLPRLPRLPRLPRLRRRRS;RLPRLPRLPRLPRLPRLPRLRRRR;RRSRCPPRLRRLPRLPRLPRLPR 4 8.8 0.99267 -0.13277 8.67649 0 0 0 0 0 0 0 9.65069 0 0 5.74365 0 0 5.7827 A0A8C0S6V0 A0A8C0S6V0_CANLF Centromere protein B Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" chromatin binding [GO:0003682]; DNA binding [GO:0003677] EAGGSFGGYG;EDGDEVPVPSFGE;EQPPSVAEGYASQDV;GEEEEEEEEEEEEEEEEEEE;GLGHQGWRQP;VDDSDEEEEEEEEESSSEGL;VPSEGSGG;WRQPHCLLIASFSES 8 17.5 1.0022 -1.3695 0 0 0 0 0 0 7.80755 0 0 0 9.56173 0 0 0 0 A0A8C0S6V2 A0A8C0S6V2_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVGEFEAGISKNVQTRE;TGTTLFEALDCIL 2 8.7 0.9902 -0.20024 7.75689 0 0 0 0 0 0 0 0 0 0 9.52191 0 0 0 A0A8C0S6Y5 A0A8C0S6Y5_CANLF Olfactory receptor LOC119880303 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CDSNVIHHFLCDL;TDSCLLAVMAFDRYVAICDP 2 10.7 0.99388 -0.056505 0 0 0 0 0 0 0 0 0 0 0 0 12.0139 0 0 A0A8C0S6Y7 A0A8C0S6Y7_CANLF Claudin-4 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] CGSASSESYTLHCI 1 5 0.98835 -0.26265 0 0 0 0 0 0 0 0 14.9028 0 0 0 0 0 0 A0A8C0S6Z7 A0A8C0S6Z7_CANLF Glutamate receptor Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] APAGPGSWTRARR;PGGAAAQP;VGIYHFSGLF;VGTVWESSAEAYIKK 4 4.6 1.0032 -1.6236 0 5.06553 0 0 0 0 0 0 9.83637 0 0 0 1.64653 0 0 A0A8C0S732 A0A8C0S732_CANLF Cullin family profile domain-containing protein CUL4A Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] NILTMGYWPTYTPMEVHLTPE;PALQPGKSDAVE 2 4.7 0.99232 -0.17645 0 0 0 9.67853 0 0 0 0 0 0 0 8.07232 0 0 0 A0A8C0S750 A0A8C0S750_CANLF EMI domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] GFTGSNCEEECMNC;LEAAEQPAGPGNDL;LILEHMIGIHDPLASPEGGSGQ;PGFTGSNCEEECMN;PGVPGSQGLAGERGMT 5 15.3 0.83956 0.19724 0 10.2325 0 0 0 0 8.98766 0 0 11.1034 0 6.8913 0 7.49538 0 A0A8C0S799 A0A8C0S799_CANLF KAP NTPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AERYFLDPELGHQKDILTEDDVYC;GGGGGGGE;GGGGGGGG;QGAEHVRGHASE;RLLWYLVFLQPVITE;TALMQQEAAQREAEELRRV;VYSVLGNKPA 7 12.5 0.99711 -0.10553 0 0 0 5.39029 0 0 0 0 9.37437 0 0 0 8.00994 0 8.3077 A0A8C0S7A2 A0A8C0S7A2_CANLF N-ribosyldihydronicotinamide:quinone reductase 2 NQO2 Canis lupus familiaris (Dog) (Canis familiaris) VLAPQISFAPEIA 1 6.7 0.98967 -0.20068 0 0 0 0 0 0 12.3012 0 0 0 0 0 0 0 0 A0A8C0S7B2 A0A8C0S7B2_CANLF Ig-like domain-containing protein OPCML Canis lupus familiaris (Dog) (Canis familiaris) CNCQCDPTSC;RLTIASTKKRGIVAF 2 9 1.0032 -0.87549 0 0 0 0 0 0 0 6.23758 11.823 0 0 0 0 0 0 A0A8C0S7C3 A0A8C0S7C3_CANLF GRIP1 associated protein 1 GRIPAP1 Canis lupus familiaris (Dog) (Canis familiaris) AEFSKLCSQM;GAAPAGSL 2 2.2 1.0023 -1.3699 0 11.274 0 0 0 0 11.208 10.7586 0 0 0 3.44308 3.3781 0 0 A0A8C0S7C7 A0A8C0S7C7_CANLF Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) Canis lupus familiaris (Dog) (Canis familiaris) DLRNNHVLDSGL;TQKALLAEIQNGCKQ;TQTQTLRRRRRTTGRRRT 3 6.4 0.99113 -0.27426 0 0 0 0 0 0 2.88358 0 0 0 0 3.21315 4.8476 5.17373 0 A0A8C0S7G1 A0A8C0S7G1_CANLF HIT-type domain-containing protein ZNHIT6 Canis lupus familiaris (Dog) (Canis familiaris) VIRQRLKAYIRSQ;VLHQDLSSCVLQ 2 5.1 0.99095 -0.27485 7.29967 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S7I5 A0A8C0S7I5_CANLF ADAM metallopeptidase domain 33 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AGDAHGNC;EECDCGASQECQDACCLAHNCSL;EEGEECDCGASQECQD;EEGEECDCGASQECQDACCLAH;EQCQQLWGPGS;GACPTLEEQCQQLWGPGS;GEECDCGASQECQDACC;GVCNSNKNCHCAPGWA;GVPCRRAVGDCDLP;IVNSAGDA;IVNSAGDAHGNCGQD;LVEEGEECDCGASQECQ;LVEEGEECDCGASQECQD;PDIYLLDGSPCASGRG;QDGKGGFVPCAQRD;QIRSKVTWEE;TWEEPDHCH;VPCAQRDAQ 18 16.8 1.0031 -2.1503 7.89712 8.10842 5.93974 0 5.29344 6.93204 16.7534 11.4956 6.88081 0 15.1096 0 0 16.3705 8.2406 A0A8C0S7K9 A0A8C0S7K9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] SEGGYCYHGNCT 1 1.7 0.94145 0.05044 0 0 0 0 0 0 0 0 0 0 5.30097 0 0 0 0 A0A8C0S7L7 A0A8C0S7L7_CANLF SprT-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; response to stress [GO:0006950] IDEDSCDQG;RIKIGIRIGIRIRIIKI;RIRIKIGIRIGIRIRIIK;RIRIKIGIRIGIRIRIIKI 4 5.5 1.0023 -0.66026 7.6279 8.15239 0 2.96918 0 0 5.46884 6.47063 0 0 0 0 0 6.8586 7.69432 A0A8C0S7N5 A0A8C0S7N5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] AEAVKGRF;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLQ 26 26.2 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 5.87165 0 A0A8C0S7P4 A0A8C0S7P4_CANLF Collagen type IV alpha 6 chain COL4A6 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; collagen trimer [GO:0005581]; membrane [GO:0016020] extracellular matrix structural constituent [GO:0005201] EELAGAGEKKSYGK;EGGGQSLV;GAPGFPGP;GPQGFAGP;GTPGRDGLPGLPG;HYFANKYSFWLTTVEERQQFREEP;LEDFRATPFIECSGARGTC;LPGPRGPMGLERLQGPP;PGPRGLPGDQGIDG;PSSNQGDPGDP;SGKAGHAG;VGLVGFPG;VGPMGPPG 13 9.4 0.99755 -3.5489 7.72533 10.0892 4.66556 12.1795 7.74248 6.35708 9.33347 0 13.8069 0 7.83731 8.99599 13.6994 12.1441 0 A0A8C0S7P8 A0A8C0S7P8_CANLF Protein PALS1 (MAGUK p55 subfamily member 5) (Protein associated with Lin-7 1) PALS1 Canis lupus familiaris (Dog) (Canis familiaris) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; generation of neurons [GO:0048699]; morphogenesis of an epithelial sheet [GO:0002011]; protein localization to plasma membrane [GO:0072659] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; bicellular tight junction [GO:0005923]; Golgi apparatus [GO:0005794]; perikaryon [GO:0043204] DLLSDMHGTLTF;GLLHEGDEVLEI;IFDTEEGIVLESP;RQQQEDMRRRREEEGKKQELDLNSS 4 10.3 1.003 -0.78384 0 11.0088 0 0 0 0 0 0 0 9.15623 0 0 0 0 9.83509 A0A8C0S7Q4 A0A8C0S7Q4_CANLF CDK5 regulatory subunit-associated protein 2 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; negative regulation of centriole replication [GO:0046600]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471] calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; transcription cis-regulatory region binding [GO:0000976] AAEGDTLRFTNQ;AIITVLCGTEGGQD;DVLSKPKGSA;EGFQEQLNQCAGL;GELGHLAHVD;HRPREVGAEACGEG;LRVELKVYERLDEEHHRPREVG;QMIRSLRGS 8 5.3 0.99006 -0.21204 7.40863 0 0 0 7.64609 0 0 0 0 0 0 0 0 0 0 A0A8C0S7Q5 A0A8C0S7Q5_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) NDUFA5 Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904] mitochondrial inner membrane [GO:0005743] GVLKKRLRILYT;GVLKKRLRILYTKIL;LKKRLRILYTKI 3 14.7 0.8567 0.15475 0 0 5.56599 0 4.82777 0 0 0 0 0 4.57749 0 0 0 0 A0A8C0S7Q6 A0A8C0S7Q6_CANLF VPS50 subunit of EARP/GARPII complex VPS50 Canis lupus familiaris (Dog) (Canis familiaris) "endocytic recycling [GO:0032456]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; EARP complex [GO:1990745] ETYIKAYYLTENDMERWIKEHR;HCIRLANRTIVEGYANVK;KEEFRELREQPSDPQAEQELINSI;LCSGNTDTKFQ;SNFSILQLHEFKFME;SQHNIYVDAL 6 10.4 1.0016 -1.3144 0 0 0 0 0 8.51865 9.03818 10.5286 0 0 0 0 0 0 12.7703 A0A8C0S7Q8 A0A8C0S7Q8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) PJA2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; regulation of protein kinase A signaling [GO:0010738] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DYYQLYDKDEDSSECSDGE;IKIIVCLSYFQLC;RSVQRWREALEVEENGSDDLLIKC 3 7.8 0.98459 -0.25339 0 12.5693 0 0 0 0 0 0 0 12.2914 0 0 0 0 0 A0A8C0S7S2 A0A8C0S7S2_CANLF Syntaxin-1A Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278] presynaptic active zone membrane [GO:0048787]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] VPGAGGGAG 1 1.6 1.0044 -0.80421 10.0569 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S7S3 A0A8C0S7S3_CANLF WH2 domain-containing protein ESPN Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] stereocilium [GO:0032420] actin binding [GO:0003779] AENGELECC;DGADGRLLRLLKQRQVVGKLLG;EEEEQRRKLTAASSCCYPREGWRY;GADGRLLRLLKQ;MLGYFQLLEMGLS;PLPAGPGMAHSEEVRA 6 6.2 1.003 -1.5152 0 0 0 0 7.99249 0 0 3.65295 0 0 9.3353 0 0 4.61111 0 A0A8C0S7T0 A0A8C0S7T0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IVKKKIRFYFVKKPRLFEKRREK;MDAFLESHKL;MNEKGEITTNT 4 8 0.97936 0.046253 6.68958 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S7T2 A0A8C0S7T2_CANLF Tetraspanin TSPAN8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] cell surface [GO:0009986]; membrane [GO:0016020] FWLCGILILAVAIWVR;IAVNILIAVGSIIMI;LFFIGLLLILLLQ 3 18.6 0.9888 -0.20303 0 0 0 7.68257 0 0 0 0 0 0 0 3.2249 0 7.42122 2.80116 A0A8C0S7T6 A0A8C0S7T6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MDAFLESHKL;MNEKGEITTNT;SEVSQSVKDKHY;SLLNKWCWENWT;VSKMYKELLKLNTKE 5 6 0.9399 0.10431 0 0 0 0 0 0 0 0 4.25754 0 0 0 6.69293 0 5.7988 A0A8C0S7V2 A0A8C0S7V2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] AEAVKGRF;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;LVESGGDLVK;SSTSYAEA 8 17.9 1.0042 -1.1044 0 0 0 0 7.05441 0 0 0 0 0 0 0 0 0 0 A0A8C0S7W6 A0A8C0S7W6_CANLF Microtubule-associated protein MAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] DLFEEKVVDKDTKVE;ELTPSPAE;GVIESVVTIE;PALEKAPCFPVESKE;PATPKQLRL;SAILVPSEKKVAIIRTPPKSP;TNTSGSMDEGDDYL;TTDEGESGAHSVRFAALE;VEEASTGLPPVT;VEEGVPEKVLGEEK 10 7.4 1.0006 -2.7699 11.114 0 0 0 0 0 10.3245 0 0 3.66471 10.4314 0 0 2.90668 6.82069 A0A8C0S7X3 A0A8C0S7X3_CANLF TNF alpha induced protein 2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] exocyst [GO:0000145] ALKKKKKKKSKGL;DEFLERCKQL;EQKWQILQ;KKKKKSKG;PLSDLKSHGFDTLLQSL;PTAEELKAELERGRLE;RDKEEALKKKKKKKSK 7 10.5 1.0035 -2.2427 0 0 0 0 9.78544 0 0 0 0 20.1219 5.02645 0 10.7777 6.08791 0 A0A8C0S7Z1 A0A8C0S7Z1_CANLF Coiled-coil domain containing 102A CCDC102A Canis lupus familiaris (Dog) (Canis familiaris) AELRGEMERLQAENAAE;ELSQWKIKYEELNKTKQE;VTVSWDPSA 3 8.2 0.85404 0.15532 0 0 0 0 0 0 0 0 0 0 0 0 10.4334 9.01976 0 A0A8C0S7Z8 A0A8C0S7Z8_CANLF WH2 domain-containing protein ESPN Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] stereocilium [GO:0032420] actin binding [GO:0003779] AENGELECC;SSSNSKAA 2 2 0.98941 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.67225 A0A8C0S806 A0A8C0S806_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] CCGGIAGT 1 3.3 0.98921 -0.26592 0 0 0 0 0 0 0 0 0 0 8.86096 0 0 0 0 A0A8C0S815 A0A8C0S815_CANLF methylmalonate-semialdehyde dehydrogenase (CoA acylating) (EC 1.2.1.27) ALDH6A1 Canis lupus familiaris (Dog) (Canis familiaris) "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]" KLFIDGKF 1 1.6 1.0038 -1.1044 0 0 7.94843 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S818 A0A8C0S818_CANLF Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 CSTPP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] HVLTYMEDA;SPERLALPDYEY;SPWRPLHHARKVDAESDGSTE 3 12.7 0.98982 -0.21284 0 0 0 0 7.87381 0 0 0 0 0 0 8.29838 0 0 0 A0A8C0S820 A0A8C0S820_CANLF Kallikrein 1 KLK1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] AAGSGPSQRHSRCSPLGVPGSVPC;SQPVLLPHPQ;VPGSVPCP 3 10.1 0.97419 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 7.57312 0 A0A8C0S821 A0A8C0S821_CANLF Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] membrane [GO:0016020] phosphatidate phosphatase activity [GO:0008195] AEKSGAAVAAASAQ;EEEEEEEEEEEEEEEEEEEGEEGGP 2 5.4 0.933 0.096571 0 0 0 0 0 0 0 9.84735 0 0 7.75295 0 0 0 0 A0A8C0S854 A0A8C0S854_CANLF EF-hand domain-containing protein PPP2R3B Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CGSGSCRC;DLYEYACED;HDLLIDSQDLARH;PGPACGGPC;TDHDLLIDSQDL;VGAPCCNL;VSLLRDSESEGPELSD 7 10.7 0.9985 -3.013 0 0 0 0 6.35198 0 0 7.23209 0 0 0 0 0 0 12.701 A0A8C0S858 A0A8C0S858_CANLF "Coenzyme Q3, methyltransferase" Canis lupus familiaris (Dog) (Canis familiaris) "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [GO:0010420]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]" CGHPGGSL 1 5.9 1.0044 -1.1044 0 0 0 0 0 0 0 3.11643 0 0 9.31245 9.81889 0 0 3.22457 A0A8C0S872 A0A8C0S872_CANLF Tigger transposable element derived 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EETGFYTSDEEDDGGS;LPVTVKKKKSLSIE;LSSVEGSKEFTFSLLDAVDTLHLCW;VGTNMDGSEKLPL;VWHQNVLPYYLNDYHPK 5 16.6 0.99156 -0.13444 6.765 0 0 0 0 9.34054 0 0 0 0 0 0 0 10.9907 0 A0A8C0S8A0 A0A8C0S8A0_CANLF Sosondowah ankyrin repeat domain family member C Canis lupus familiaris (Dog) (Canis familiaris) GALDEDDGDCAAGGGGGR;GDCAAGGG;GGSVTLDPLEHAW;LSHVLEDGGD;SSPGSSSGGGRGKGGGDSDSASV 5 13.2 1.0025 -0.98138 13.4831 13.4256 11.0479 12.506 12.4917 12.6634 10.8431 13.022 12.976 10.3115 9.79886 13.2038 0 0 9.91251 A0A8C0S8C8 A0A8C0S8C8_CANLF IRS-type PTB domain-containing protein DOK4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737] GVQCEQTDRFNVFL;LLEMEKNVRVRHGHQP;TDDSARTF 3 11.1 0.98622 -0.38899 0 0 0 0 0 6.44047 0 6.10629 0 0 0 0 0 0 0 A0A8C0S8D5 A0A8C0S8D5_CANLF Contactin-associated protein-like 4 CNTNAP4 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604] calcium ion binding [GO:0005509] DLDHEISFGGI;GAVLKLLLLL;LDALWCKN;LDALWCKNP;SGGTYYFGGCPDNSFGSK;TYWGGSLPDPQKCTCGLE;VTPGVEPGCRGHCSS 7 6.9 1.0039 -1.6831 0 9.88999 8.60766 0 9.58474 0 10.0583 10.2909 0 9.84449 8.92318 0 0 2.5554 9.8345 A0A8C0S8E6 A0A8C0S8E6_CANLF Suppressor of white apricot N-terminal domain-containing protein CLASRP Canis lupus familiaris (Dog) (Canis familiaris) DSPTYDPY;EESPAEEE;EEWERQYSRQS;QEKLKLRMQKALNRQ;QSRSPSPRYSREYSS;TEPAAGKETGAA 6 10.9 1.0022 -1.422 0 0 9.74478 0 9.51335 0 0 7.27817 6.32204 0 0 0 5.36933 0 0 A0A8C0S8F4 A0A8C0S8F4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CHVPGGNSRP 1 13 0.99012 -0.21696 0 0 0 0 0 0 0 0 0 0 8.81346 0 0 0 0 A0A8C0S8G8 A0A8C0S8G8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) EWIKKMWFMYIQ;MNEKGEITTNT 2 2.8 0.99377 -0.12988 0 0 0 0 0 0 0 0 0 0 0 0 10.4253 0 0 A0A8C0S8H1 A0A8C0S8H1_CANLF Hexosyltransferase (EC 2.4.1.-) B3GALT2 Canis lupus familiaris (Dog) (Canis familiaris) galactosylceramide biosynthetic process [GO:0006682]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" FLFAMFLFFNHHDWLPGRAG;HLEDVYVG 2 6.6 0.98982 -0.21291 9.62326 9.84147 0 0 7.35332 0 0 11.4162 11.6353 0 0 0 0 0 0 A0A8C0S8I2 A0A8C0S8I2_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGGKHGEG;GGGGGGGA;GGGGGGGG;GVRRNRRRRQKRRR;RAAAGCGELKWLTCLE;SRRRTRRTRTRRTRRTRREEQAL 6 19.4 1.0021 -1.2389 0 0 0 0 0 0 0 0 10.1555 0 0 0 9.35288 0 5.45815 A0A8C0S8K6 A0A8C0S8K6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) PJA2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; regulation of protein kinase A signaling [GO:0010738] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] IKIIVCLSYFQLC;RSVQRWREALEVEENGSDDLLIKC;YYQLYDKDEDREQTS 3 7.6 0.98724 -0.36322 14.7656 9.82443 0 0 0 0 0 0 0 0 0 0 0 10.0126 0 A0A8C0S8L8 A0A8C0S8L8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) DLEKKQQIDPTPSRRRELIKIRA;MNEKGEITTNT;NYFKICVESEKTPNSQ;VRTNYFKICVE 4 7.4 0.99022 -0.20093 0 0 0 0 0 0 0 0 7.70113 0 0 0 0 6.11805 0 A0A8C0S8M9 A0A8C0S8M9_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SOHLH2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; neuron projection morphogenesis [GO:0048812] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ELITMMLLV;IRPKLVTIIRSGVKPRKAVRILLN;IRPKLVTIIRSGVKPRKAVRILLNK;LVEGESYVCG;LVYEHQDGSKSL;MDENDGPGE;SPTSPGSLRKQRSSQHGGSSTSLAS;SQCFHGNVLAVSINQFLQWINML;VLFDQILMGQVDF;YRNGDRYFKGIVYAISPDRFRSF 10 20.3 0.97765 0.046334 0 0 0 0 0 0 0 0 11.0027 0 0 0 0 0 0 A0A8C0S8P4 A0A8C0S8P4_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RMND5B Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AGGPEKQLEALSYA;EERTFQDHPLL;EIELGMKCWYHSVFACP;ESTLNVDLDFKQPFLE;GRAEGAVVSDFP;QMAIVEHLYQ 6 12.8 0.98734 -0.3514 0 9.62569 10.4061 4.89869 0 0 0 0 0 0 9.55055 0 0 0 7.94017 A0A8C0S8P7 A0A8C0S8P7_CANLF C2H2-type domain-containing protein SNAI1 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VFILQATFCTKETFCI 1 6.3 0.96171 0.049233 0 0 7.52834 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S8Q8 A0A8C0S8Q8_CANLF T-box transcription factor TBX20 Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DIVPVDNKRYRYAYHR;ELWDKFHELGTEMIITKSGRRMF;IKPLEQFV;LLKQMVSF;PYAAIQGLRH;SSSFPGFQHPQSL 6 17.4 1.0028 -1.9023 8.71894 0 11.0523 9.92136 0 0 0 10.7766 0 0 8.95155 0 0 0 10.0963 A0A8C0S8R7 A0A8C0S8R7_CANLF Cyclic AMP-responsive element-binding protein 5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" CELGRVTEEALEVIAKG;PFVCSAPG;QSSSVITQAPSTNR 3 6.3 1.0029 -1.195 0 0 8.40569 0 0 0 0 0 0 0 0 10.1187 0 0 0 A0A8C0S8S6 A0A8C0S8S6_CANLF ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) DDX1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] ATP binding [GO:0005524]; DNA binding [GO:0003677]; exonuclease activity [GO:0004527]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GFVALAKA;IVCSATLHSFDV;IVCSATLHSFDVKKLSEK;KGDVRFLICTD;PDKKGHQFSC 5 6.6 1.0032 -2.1432 0 0 6.9148 0 11.2883 6.80025 0 0 0 0 0 0 9.87874 3.53007 0 A0A8C0S8X1 A0A8C0S8X1_CANLF ATP binding cassette subfamily D member 4 ABCD4 LOC119869278 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LDESEWNMDRAPG;LFYLQPKYAVSL 2 3.7 0.93839 0.071205 0 11.7739 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S8X9 A0A8C0S8X9_CANLF Heat shock protein HSP 90-beta Canis lupus familiaris (Dog) (Canis familiaris) cellular response to heat [GO:0034605]; protein stabilization [GO:0050821] basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; unfolded protein binding [GO:0051082]; uridine transmembrane transporter activity [GO:0015213] ASAAMICAIASGSELSESAFG;EIFLRELISNASD;SKILKVIRKNIVKKCLELFSE;SQSGDEMTSLSEYV 4 6.3 0.97505 0.047166 0 0 0 0 0 0 0 0 0 0 0 4.87263 0 0 0 A0A8C0S902 A0A8C0S902_CANLF Hemoglobin subunit zeta (Hemoglobin zeta chain) (Zeta-globin) Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744] blood microparticle [GO:0072562]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] haptoglobin binding [GO:0031720]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] VLRPDREVPL 1 4.5 0.99869 -0.61146 0 0 0 0 0 0 0 0 0 0 2.15617 0 0 0 0 A0A8C0S934 A0A8C0S934_CANLF Cupin type-1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] DVFFSVPEDI;EKKKKKKKKTKL;EKKKKKKKKTKLVP;FLNQHQNA;IRTFQKQQEDQGV;ISEKKKKKKKKTK;KKKKKKKK;KKKKKKKKTKLV;KKKKKKKKTKLVPYKRG;KKKKKKKTKLVP;KKKKKKKTKLVPYKRG;KKKKKKTKLVP;QGTAWIGVVA;SEKKKKKKKKT;VGTQHYIRSACDE;VISEKKKKKKKKTKL;VISEKKKKKKKKTKLVP;VISGCAKVGII 18 22.8 1.0026 -0.7262 0 9.75912 9.30095 9.57192 3.46284 11.2471 7.55244 10.6008 7.072 5.5587 6.53099 0 9.16166 6.95722 0 A0A8C0S935 A0A8C0S935_CANLF Family with sequence similarity 181 member B Canis lupus familiaris (Dog) (Canis familiaris) GPSGPGVSLGDLEKGADAVEFLE;PGGEDAPGLLASFAP 2 8.8 0.93984 0.10035 0 0 9.6094 0 0 0 0 0 0 0 0 0 0 0 5.97159 A0A8C0S939 A0A8C0S939_CANLF Zinc finger protein 197 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVSVCFTSEEWEC;KVFILKKSLILHQRFHTG;LRYHETSGPQEALSRLR;LSESLIATEGKKFYKCDICYKHFN 4 7 0.99062 -0.13569 0 0 0 0 0 5.57743 9.1047 0 9.56217 0 7.61912 0 0 0 0 A0A8C0S943 A0A8C0S943_CANLF Proteasome maturation protein Canis lupus familiaris (Dog) (Canis familiaris) proteasome assembly [GO:0043248] cytoplasm [GO:0005737]; nucleus [GO:0005634] LGSQLKDNIPVT;LSASGTFEQRDLLR 2 20.8 0.99148 -0.1484 0 0 7.06641 0 0 0 0 0 4.91131 0 0 0 0 0 0 A0A8C0S987 A0A8C0S987_CANLF "Beta-1,4-galactosyltransferase 7" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] glycosyltransferase activity [GO:0016757] GVSAAWLLASP;VSAAWLLASPWALP 2 3 0.99447 -0.56091 0 0 0 0 0 0 0 0 0 0 0 0 0 9.53282 0 A0A8C0S993 A0A8C0S993_CANLF HIT-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] Swr1 complex [GO:0000812] nucleosome binding [GO:0031491] GKNSSGVG;VGKKKKKTRGDHFKLRFRK 2 15.3 1.0039 -1.055 0 9.56813 0 0 0 0 0 0 0 8.69512 0 0 0 4.01952 0 A0A8C0S9B9 A0A8C0S9B9_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] ASKKQREKLLELIRRL;DFFESNVLQLDPSLLT;DHMMKRMSYRRQKRWWNAYILFYER;ELFARSPDPRSP;FMHNRMQYSL;FQTPEKKYHIGCEKGG;GEYMGEVFDHMMKR;GFHTKKIVR;HNRMQYSLEYF;KRLLIKKLPPV;LLIKKLPPVLAI;LLIKKLPPVLAIQ;SAIERSVRKQN;SLEYFQFMKKLLTCNGVYLNPP;SLSPSLDSLFFGPS;STARERAK;TVKRLLIKKLPPVLAIQL;TVKRLLIKKLPPVLAIQLK;TVKRLLIKKLPPVLAIQLKR;VKRLLIKKLPPVLAIQLKRFD;WFPLLELLSMALNPHCKFH;WNAYILFYERLDTI;YYVPRGFWKQFR 23 8.7 0.99956 -2.9132 0 10.9648 10.9051 10.7377 7.98823 5.30725 7.71253 8.96047 10.8187 0 3.84499 6.73566 8.53543 0 7.11228 A0A8C0S9C1 A0A8C0S9C1_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] EQFQRLANAYFL;LRFPELYDPGQHNL;QTVYDTWF;RLLLVHGR;VLTGDKQETAV;VVCFLFFFHSQNNTIKTSRYN 6 6.7 1.0012 -0.9452 0 0 0 5.77001 0 0 0 0 0 9.83341 6.69056 0 10.535 0 0 A0A8C0S9D4 A0A8C0S9D4_CANLF Transmembrane protein 255B TMEM255B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LFAAIVFI;PVPGEPAAAD;RPEALEGFPAGLP;SSTCYCCDLYNCQSTE 4 9.5 0.98735 -0.36575 0 0 8.29889 8.79666 0 0 0 0 0 11.1807 0 0 0 9.2692 0 A0A8C0S9D6 A0A8C0S9D6_CANLF AH domain-containing protein ARFIP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] protein domain specific binding [GO:0019904] EAAGPGVL 1 1.7 1.0046 -1.1044 0 0 0 0 9.51684 0 0 0 0 0 0 0 0 0 0 A0A8C0S9E2 A0A8C0S9E2_CANLF UPAR/Ly6 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAVLWALLL;GNLSCYQC 2 12.6 1.0026 -1.3755 0 7.82133 0 0 0 0 0 0 0 0 0 7.85972 0 0 0 A0A8C0S9F6 A0A8C0S9F6_CANLF Growth arrest specific 6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] calcium ion binding [GO:0005509] AKQGHLERECIEELCS;ELCSQEEAREVFE;TISVEELDRN 3 5.6 0.99148 0.009051 0 0 5.62638 0 0 9.5109 0 0 9.14524 0 0 0 0 0 0 A0A8C0S9G2 A0A8C0S9G2_CANLF BHLH domain-containing protein MYCN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] AGASGAGAAASAGAPA;DDEDDEEEDEEEEIDV;DTLSDSDDEDDEEEDEEE;ECVDPAVVFPFPVN;PHPQPGHPA;VILKKATEYV;VVFPFPVNKREPAPAAPAG 7 18.7 0.99563 -0.568 0 0 4.58466 7.60792 0 8.60017 0 6.56142 0 11.8734 0 0 0 7.92041 0 A0A8C0S9I4 A0A8C0S9I4_CANLF Aminotransferase class I/classII domain-containing protein KYAT1 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170] AGGHPVFV;QHDVICITD;TKAFVIIIEP 3 7.2 1.003 -1.3287 11.2655 0 10.7553 0 0 0 10.6354 0 0 10.3622 10.7295 10.7068 10.4705 0 0 A0A8C0S9J4 A0A8C0S9J4_CANLF Olfactory receptor OR6S1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLSRQHTISFAACITQ;TEFILAGFPNLNN;VLRIPSVSG 3 11.5 1.0029 -0.73655 0 0 11.9364 7.2317 0 9.33201 0 0 0 7.23582 7.39069 7.77202 0 0 0 A0A8C0S9J6 A0A8C0S9J6_CANLF F-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LDGHNDTGLVFA;SLTDLQKNETLDHLI 2 5.9 0.93794 0.10432 0 0 0 0 5.29418 0 0 0 0 0 11.3475 0 0 0 0 A0A8C0S9K0 A0A8C0S9K0_CANLF Corticotropin-releasing factor receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] neuron projection [GO:0043005]; plasma membrane [GO:0005886] corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone binding [GO:0051424]; corticotropin-releasing hormone receptor activity [GO:0043404]; G protein-coupled peptide receptor activity [GO:0008528] ATPRAGKGGQHRGGAGSP;GRRPQLRLVKALLLLGL;LSPPGAPQAPWT;PGCGGRHRCLCV;RCLRNIIHW;YTDYIYQGPMILVLLINFI 6 12.3 1.0037 -0.8344 0 0 0 8.32418 0 5.2245 0 0 0 7.19357 0 0 0 0 0 A0A8C0S9K7 A0A8C0S9K7_CANLF Oxysterol-binding protein Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] EDEFYDADEF;ISTTLAFFQSSGI;KKLPIIKKKVRKL;KLPIIKKKVRKLE;PNSTGSGHSPP;SLKRPDTTESLNSSMSNGT;WNGVMYAKYATGE 7 10.7 1.0022 -1.019 0 0 4.2156 0 0 10.5914 0 0 0 0 0 0 0 0 7.09286 A0A8C0S9M0 A0A8C0S9M0_CANLF Cochlin COCH Canis lupus familiaris (Dog) (Canis familiaris) DDVRGPAAAAHDAGI 1 2.9 0.99587 -0.095446 0 0 8.63579 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S9M6 A0A8C0S9M6_CANLF Sodium channel and clathrin linker 1 SCLT1 Canis lupus familiaris (Dog) (Canis familiaris) clustering of voltage-gated sodium channels [GO:0045162] DLQLRLKTA;KQLHVTKE;PLSMSFKICCL;RPLSMSFKICCLPFQS 4 5.1 1.0022 -1.4064 0 9.63121 9.44522 0 6.15892 0 0 0 0 11.5878 0 0 0 0 0 A0A8C0S9N1 A0A8C0S9N1_CANLF BHLH domain-containing protein MLXIPL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] DQMRDMFDDYVRTRT;GCFEEASTMLCRLALSPD;KDFLQREHRSLRANV;PTPQPGPG;REHPACAPWPGPQT;TANPEDFPKK;WKRRIEVVMREYHKWRIYYKKRLRK 7 8.2 1.0032 -0.87151 0 0 12.2015 0 0 10.6684 0 0 0 0 10.512 4.87892 0 0 0 A0A8C0S9N8 A0A8C0S9N8_CANLF Tetraspanin TSPAN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVAIRHVQTMYEEAYN;YLLLGFNLLFWLAGSAVIGFGLWFR 2 18.6 0.94559 0.084771 4.80318 0 0 0 0 0 0 0 0 0 0 0 10.0038 0 0 A0A8C0S9N9 A0A8C0S9N9_CANLF C3H1-type domain-containing protein ZC3H12C Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] IDERLLMYSFVN;ILRKLEKEKILVFTPSRRVQGRRVV;LDNFLRKKPIVPE;PFAFQSLPERPEPAWRG;SVASDCSSEGSMSCGS;TLDFISTQEYGV 6 10.7 0.94137 0.064193 8.84012 0 0 0 0 10.1804 0 4.40592 3.6597 0 0 10.7106 0 0 0 A0A8C0S9P1 A0A8C0S9P1_CANLF BTB domain-containing protein SHKBP1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] EIAYGTSSGG;IFIDRDPTVFAP;MVRLVCGHHNWIAVAYTQFLVCYR;PAGGLTEEELMEQLEQC 4 9 0.99439 -0.15489 8.35067 10.5244 0 0 0 6.82094 0 9.43773 0 0 0 0 0 0 0 A0A8C0S9Q2 A0A8C0S9Q2_CANLF PA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" DIQVQSSRVYF;FHKRPRVSMLLLALLCLAVS;TEQGPQLGSHWGG 3 7 0.99248 -0.19209 0 0 0 7.50859 0 0 0 0 0 0 0 0 0 7.20428 0 A0A8C0S9U1 A0A8C0S9U1_CANLF Ribosomal protein S4 X-linked RPS4X Canis lupus familiaris (Dog) (Canis familiaris) EDETQDDDLDEMM;GPIPPSVAKKAIRKLKQ;LEPFSGDPVYLAEFLM;NNDDSDDEEYYSDED;PFAADPNNDDSDDEEYYSDEDE 5 12.3 0.9959 -0.013451 5.92044 0 0 8.47196 0 11.131 0 0 0 0 0 0 6.63726 0 0 A0A8C0S9U3 A0A8C0S9U3_CANLF "Atypical kinase COQ8A, mitochondrial (Chaperone activity of bc1 complex-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3)" PSEN2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; intracellular signal transduction [GO:0035556]; protein processing [GO:0016485]; ubiquinone biosynthetic process [GO:0006744] membrane [GO:0016020]; membrane-bounded organelle [GO:0043227] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" EFHFMQTDPNWSNFFYDPQQHKVA;EMEEDSYDSFGEPSY;GAALKLGQML;GALQLPYDPEMEEDSYDSFGEPSY;LFEFHFMQTDPNWSNFFYDPQQH;PPDFSAATSPDRGDHTGS 6 10.3 0.9428 0.087556 0 9.24612 0 0 0 0 0 9.4177 9.30574 0 0 0 0 0 0 A0A8C0S9U6 A0A8C0S9U6_CANLF ATP binding cassette subfamily D member 4 LOC119869278 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ELYRIGQQLGMTF;LDESEWNMDRAPG;VLSACTTCFL 3 6.4 1.0045 -0.81894 0 8.52313 0 0 0 0 0 0 0 0 0 0 10.5558 0 0 A0A8C0S9U7 A0A8C0S9U7_CANLF PHD finger protein 19 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] AAKAYVPLRAKRR;DSPHRTNQQQCYCYCGGP;HHWELLQLGKVPVRQ;QCYRCRQWFHEACTQ 4 11 0.95087 0.053874 0 0 0 4.43583 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S9V8 A0A8C0S9V8_CANLF Parvalbumin IFT27 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport [GO:0042073] cilium [GO:0005929]; cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVDGDSAVG;HHLYREKVE;KSGFIEEDEL 3 10.1 1.0016 -0.70385 12.0374 0 0 0 0 0 15.4498 0 11.3326 11.5968 15.8724 15.4857 11.8876 15.4808 0 A0A8C0S9W3 A0A8C0S9W3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] membrane [GO:0016020] ubiquitin protein ligase activity [GO:0061630] AGERQRRPPEPDRQAR;GGGGGGGG;HYGGGGGGG;PPGAAPGPGSPSPS;WLGPPGAIACPVCRHRT 5 17.1 0.98956 -0.52889 12.1846 12.2783 11.4997 0 0 0 12.4308 0 0 0 0 0 0 11.9395 0 A0A8C0S9X1 A0A8C0S9X1_CANLF Cytohesin Ubiquitin Protein Inducing domain-containing protein CCDC120 Canis lupus familiaris (Dog) (Canis familiaris) DLYGDLKNRRNSVASP;MGFPRADPASDRAS;QLSQEDVVLHSESSSL 3 7.9 0.98728 -0.40472 0 0 10.1037 0 0 0 10.8199 0 8.27226 0 0 0 0 0 0 A0A8C0S9Y0 A0A8C0S9Y0_CANLF Rad50/SbcC-type AAA domain-containing protein SMC6 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697] AADGGLHVPS;DKDGDEDEC;EEFLRRRQIHYRELKVK;RKEELIAILDH;SGGGGGGA 5 4.6 0.9984 -0.61146 7.94246 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S9Y7 A0A8C0S9Y7_CANLF "Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1)" Canis lupus familiaris (Dog) (Canis familiaris) selenocysteine biosynthetic process [GO:0016260] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] "ATP binding [GO:0005524]; selenide, water dikinase activity [GO:0004756]" VSVGGWSGRVD 1 3.1 0.97921 0.035491 0 0 0 7.26153 0 0 0 0 0 0 0 0 0 0 0 A0A8C0S9Z3 A0A8C0S9Z3_CANLF Tetratricopeptide repeat protein 7 N-terminal domain-containing protein TTC7A Canis lupus familiaris (Dog) (Canis familiaris) MSMENKPLYQMRLLAEAFVIKAR;WDRMPELVRQLQALLGPGGGGG 2 19 0.97566 0.046453 0 0 0 0 0 0 0 0 7.80349 0 0 0 0 0 0 A0A8C0SA11 A0A8C0SA11_CANLF Coiled-coil domain containing 178 CCDC178 Canis lupus familiaris (Dog) (Canis familiaris) EALQTGGPLQPDEAGQV;EANAKLQADIDYMNKHGPLIN;ESEIQSLMKLR;VPDRLSREYSENISCAGGI;YVKRNVERTKKKLRRKGK 5 9.8 0.99272 -0.28654 11.068 0 7.38405 0 0 0 0 7.67546 0 0 0 0 0 13.0211 0 A0A8C0SA17 A0A8C0SA17_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] EVQLVEPGGDLVKPGGSLRL 1 11.2 0.9509 0.053064 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.91534 A0A8C0SA33 A0A8C0SA33_CANLF Calsequestrin CASQ2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881] sarcoplasmic reticulum lumen [GO:0033018]; Z disc [GO:0030018] calcium ion binding [GO:0005509] DDDDDDGNNSDEESNDDS;DDDDDGNNSDEESNDDSDDDGWRH;DDDEDDDDDDGNNSDEE;DDDNEEGDDGDDDEDDDDDD;DDEDDDDD;DDGDDDEDDDDDDGN;DDGDDDEDDDDDDGNN;DDGNNSDEESNDDSDDD;DEDDDDDD;DEDDDDDDGNNSDEESNDDSDDDG;DGDDDEDDDDDDGNN;DNEEGDDGDDDEDDDDDDG;DNEEGDDGDDDEDDDDDDGNN;EDDDDDDGNNSDEES;EDDDDDDGNNSDEESNDDSDDDG;EDDDNEEGDDGDDDEDDDDDDGNN;EGDDGDDDEDDDD;EGDDGDDDEDDDDDD;EGDDGDDDEDDDDDDGNNSDE;ESNDDSDDDGWRH;GDDDEDDDDDDGNNSDEES;GDDGDDDEDDDDDDG;GKINTEDDDNEEGDDGDDDED;INTEDDDNEEGDD;LPTAEELEDWI;LSGKVKGDF;NEEGDDGDDDEDDDDDDGNNS;NEEGDDGDDDEDDDDDDGNNSD;NTEDDDNEEGDDGDDDED;VAFAERSDPD 30 13.9 0.98796 -0.5051 7.04461 10.2064 8.35191 8.98479 3.2185 0 7.51562 7.06296 5.29359 6.69209 5.96528 0 7.19604 7.83637 8.82956 A0A8C0SA35 A0A8C0SA35_CANLF RAD51 interacting motif domain-containing protein RAD51AP2 Canis lupus familiaris (Dog) (Canis familiaris) HPKNDSSECVIHQFE;LPLKTCSRPIRIGLSRKAKLKQ;QEGSHLGNIFESLI;STEALTIA;VRDFTNIYWSQ;WSQNRPDVKKQ 6 6.8 0.9736 0.046699 0 0 0 0 0 0 0 4.72689 0 0 0 0 0 0 0 A0A8C0SA70 A0A8C0SA70_CANLF GATOR complex protein NPRL3 (Nitrogen permease regulator 3-like protein) Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; TORC1 signaling [GO:0038202] GATOR1 complex [GO:1990130]; lysosome [GO:0005764] HEERRCQYLTREAK;LRPHPLLGTRPRP;VILATILATKSEMC;VYWGKAII 4 7 1.0024 -0.75678 0 9.0456 0 0 0 0 0 0 9.2422 0 0 0 0 9.75015 0 A0A8C0SA71 A0A8C0SA71_CANLF TSC22 domain family member 2 TSC22D2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] VGQPQPPP 1 1.1 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 8.02198 0 0 0 0 0 A0A8C0SA83 A0A8C0SA83_CANLF aspartate transaminase (EC 2.6.1.1) GOT1L1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] ELVENIML 1 2 0.99777 -0.098378 0 0 0 0 0 0 0 0 0 0 8.66128 0 0 0 0 A0A8C0SAB4 A0A8C0SAB4_CANLF Latent transforming growth factor beta binding protein 4 LTBP4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ASCLDVDECSEEDLCQSGIC;CCRGAGLA;DVDECATGGRCQHGECAN;ECVDNDECA;EPPPCGPG;GRRPLLLVLLLP;LRGGECASPLPGL;PSGRRPLLLVLLLPL;PTGFLPTHRPEPPPEPRPG;SYHCTCEPPL;TAGSECEDVDECENHLACPG;VYTMPLAN;YHAQRLECVDNDECADEEP 13 9.7 0.97252 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 4.8387 0 A0A8C0SAB9 A0A8C0SAB9_CANLF EGF-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FLGESMSIVSL;MTTSTAWPD;PDASTSTASPDL;PDVTISTE;SPTSQDVTRSTVSPDGTR;SPVLTTSTASP;SQDGTTAASLDGTTSTSSPNGTTST;TAWPDGSTSTPSPVMTSSTAS;TLSPDISTLTSPD;TLTSPDTTTS;TSTLSPDI;TVSPDRTTS;TVSPEISTSTASPDA;VSPEMRKSPT 14 8.8 1.0033 -2.216 11.1651 10.2502 9.27384 8.70432 9.75749 0 0 11.6825 11.6496 0 0 10.6009 10.7323 0 12.1477 A0A8C0SAC6 A0A8C0SAC6_CANLF Anaphase-promoting complex subunit 2 TPRN Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] membrane [GO:0016020] phosphatase binding [GO:0019902]; ubiquitin protein ligase binding [GO:0031625] AGLTGDSDGTGDLAVELSKTDPAS;DPVDADPG;EAQEEAEEEEEEEEEEE;GQDSEDDSGEPEDWVPDPVDA;HSVQVESQLMDPE;LLLAWNTV;LSRATGSLGE;SDIISLLVSI;SEAQEEAEEEEEEEEEEEELS 9 9.6 0.98806 -0.47026 0 0 0 0 0 0 0 11.2939 0 0 0 0 0 13.0521 0 A0A8C0SAC7 A0A8C0SAC7_CANLF "Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1" SVEP1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] calcium ion binding [GO:0005509] EAPQISCPKDIEAKTQE;EDAAGRRV;EQQDSANITWQI;FVFGSKYSFES;GVREEVRCTTSGKWS;GVSEITCEANDQWSSGFPRCEHT;HYQYGDMITYSCYSGYML;LENGTWTSPPICRAVCRF;LNPCHNSGTCQ;NWDAEFPSCKPVNCG;PVNGDFICTQDSAGVNCTL;QFECVCEKGYYGKGLQYECTAC;RCHCVSAWTGHDCSRKR;VLCLPPPLISFGVPAPS;VLNTSAKIECLKGGQWN;YELQGNKERVCQ 16 7 1.0018 -1.3101 0 6.45312 0 7.72942 0 0 9.86397 0 10.6179 0 10.7697 10.703 6.99424 8.18403 0 A0A8C0SAF1 A0A8C0SAF1_CANLF Transformation/transcription domain associated protein TRRAP Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; regulation of DNA-templated transcription [GO:0006355] NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; SAGA complex [GO:0000124] AAQIKTLSFL;DQMMQHLRKWMEV;EENGSKGMDPLVLIDAIA;ENVTSSPQYSTF;FHTIARYQLSAIFKKCKPQSELG;GATIEVDQIHTHMR;HYYIKIARFMPRVEIVQKHNTAARR;KDLRPSALP;MWSKSELKLQ;SDCKASLQLPMEKAIETALDCLKSA;VLEHFAGVFT;VRAELMQALWRTLRNPAD 12 5 1.0032 -2.3589 11.0464 10.7212 12.8463 0 10.6911 0 0 11.5438 0 7.55259 9.18247 0 5.13775 0 10.246 A0A8C0SAF3 A0A8C0SAF3_CANLF BTB domain-containing protein RCBTB2 Canis lupus familiaris (Dog) (Canis familiaris) DAQDLEEFCF;SGFAEMDHDLLKNFISRASRI;SLCSEEEL;SLSYGESGKPVQATLSSL;TDDVFACFATPAV 5 11.7 0.99411 -0.56155 0 8.27421 8.0054 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SAG1 A0A8C0SAG1_CANLF Sorting nexin 19 SNX19 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] ASGRLHLERFIPVASCPASPEAERQ;GEQGDVTSLTALLP;NMQKVLHLVFGTLI;TPRGWNQDEE;VEVQSLPEVRAPSPG 5 7.9 0.9856 -0.43023 0 0 0 0 10.8846 0 10.2365 9.00473 0 0 0 0 8.93351 0 0 A0A8C0SAG8 A0A8C0SAG8_CANLF Actinin alpha 4 ACTN4 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] CQRKTAPYKN;PGPAAGPGLG;PKMLDAEDIVNTARP;WLEDRVPQKTIQEMQQKLEDFRD 4 6.1 1.0028 -0.7859 0 8.18369 0 0 0 0 0 0 0 0 8.25593 0 0 6.54138 0 A0A8C0SAH5 A0A8C0SAH5_CANLF POTRA domain-containing protein SAMM50 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] VLIDTCQGDDALPNGLDVTFEVTEL 1 5.5 0.97503 0.035538 0 0 0 0 0 9.32305 0 0 8.94193 0 0 0 0 0 0 A0A8C0SAJ2 A0A8C0SAJ2_CANLF Kinase (EC 2.7.-.-) Canis lupus familiaris (Dog) (Canis familiaris) inositol phosphate biosynthetic process [GO:0032958] kinase activity [GO:0016301] DEGSLTPTTTLGLLGDL;GGGGGGGA;GGGGGGGG;PGGGGGGG;PGPAALSEPG;PPGGGGGGG;SLLFIHDQKEQAKVWMIDFG 7 8 0.98627 -0.41376 0 0 0 0 0 0 10.9431 8.43062 0 0 0 0 0 0 0 A0A8C0SAJ4 A0A8C0SAJ4_CANLF Mitochondrial ribosomal protein L27 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] TLAISCWHCLE 1 5.6 0.99079 -0.21016 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.74382 A0A8C0SAK7 A0A8C0SAK7_CANLF SAM domain-containing protein SCMH1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] EMAPIRIFHKEP;KGLLRKLTVI;LDYSPKGLLRKLTVI;NDFWRLVDSAE;VGWCSLTGDNLQ;VLVTFDGWRGAFDYWC 6 10.3 1.0011 -0.92154 0 0 0 0 0 0 7.85935 0 0 0 0 0 0 0 0 A0A8C0SAK8 A0A8C0SAK8_CANLF Interleukin 3 receptor subunit alpha IL3RA Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] cytokine receptor activity [GO:0004896] EWKVLSHFNHRF;RAGTVTRGEAPTRRV 2 5.3 0.98531 -0.24105 0 0 10.7112 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SAK9 A0A8C0SAK9_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] keratin filament [GO:0045095] structural molecule activity [GO:0005198] ENNLRLAVNADING;GGGSGGKG;GGSGGSYGG;GGSGGSYGGGSGSKGGSGR;LEGGQEDFSGGGSGGSHGG;LEQEIKTY;QEVMSSGQEMESN;SGGGRGGGCEEGSGSG;SGGSYGGG 9 27 0.85492 0.16371 8.6575 8.25214 0 0 0 0 0 0 0 0 0 0 0 0 8.80038 A0A8C0SAL0 A0A8C0SAL0_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954] membrane [GO:0016020] C-C chemokine receptor activity [GO:0016493] AADQWVFGLGLC;LLFPSQASAWAQTCVEEPV;LLFSTCYTERNHT 3 10.8 0.98921 -0.19956 0 0 0 0 0 0 0 11.5469 7.74631 0 0 0 0 0 0 A0A8C0SAL2 A0A8C0SAL2_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713] ISHMWQSADTSK;LDELYEIMHSCWR;VGPFSDPVKMFIPPHGWVDFAPSST;YDYLLHGHRLKQPE 4 7.8 0.99458 -0.083983 0 8.7952 8.4165 0 0 0 8.23879 0 0 0 5.8732 0 0 0 0 A0A8C0SAM2 A0A8C0SAM2_CANLF "RNA transcription, translation and transport factor protein" Canis lupus familiaris (Dog) (Canis familiaris) NIHSSDWPKFFEKYLRDVNCPFK;QDAVAKANQTKEEMQF 2 20.9 0.96293 0.049233 0 0 0 0 0 0 0 0 0 0 0 8.04275 0 0 0 A0A8C0SAN0 A0A8C0SAN0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] DTVSRPQCDPR;EGVHSSPLLS 2 14 0.98467 -0.25714 0 0 0 0 0 12.4645 0 0 0 0 0 0 13.7607 0 0 A0A8C0SAQ1 A0A8C0SAQ1_CANLF NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) Canis lupus familiaris (Dog) (Canis familiaris) cholesterol efflux [GO:0033344]; intracellular cholesterol transport [GO:0032367] extracellular region [GO:0005576] cholesterol binding [GO:0015485] NCPIQKDKTYSY;PVSVELCAHHC;VELCAHHC;VLASCHWCHF 4 13.3 1.0031 -1.4947 0 0 0 6.23632 0 0 11.5 0 0 11.8502 0 0 0 0 10.8595 A0A8C0SAQ3 A0A8C0SAQ3_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155] actin binding [GO:0003779] KDLLATLHLLVA;VQVEVITMEST 2 7.6 0.98853 -0.50609 0 0 0 8.0278 9.61425 0 0 0 0 0 0 0 0 0 0 A0A8C0SAQ8 A0A8C0SAQ8_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MRVYAGRKHFIY 1 3.5 0.9536 0.05044 0 0 0 0 0 0 0 8.35134 0 0 0 0 0 0 0 A0A8C0SAS3 A0A8C0SAS3_CANLF Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAGLALSLTKF;LCSWFRVVPRDREARR;TIGSWINHFFQLAPGPPGPPPPAA;YFYYYLFRFSAALGQ 4 17 0.99059 -0.19536 9.83633 0 0 10.3271 0 9.66966 13.0669 10.8227 0 0 0 0 0 0 0 A0A8C0SAV3 A0A8C0SAV3_CANLF Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (Serine/threonine-protein kinase SAK) PLK4 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; cleavage furrow [GO:0032154] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGVYRAESIHTGL;LYLHSHGIL;YLMSDRASLNKMI 3 3.8 0.98779 -0.49486 0 0 8.22144 0 0 0 0 0 0 0 7.9341 0 0 0 0 A0A8C0SAW0 A0A8C0SAW0_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] EVNRDWLQPLLHRVK;LDTDMFGDGS;LVVCKNGDDKQ;QHWDLSLFRQ;RRLTRRLALP 5 10 1.0023 -1.4505 9.27898 0 0 8.59492 0 0 6.04039 10.1283 0 0 0 0 0 0 0 A0A8C0SAY5 A0A8C0SAY5_CANLF Complement C5 C5 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]" extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] DYQAIAYSSLS;IEDLRALVEGVDQL;LSPATFTVYE;NLPSGATVLEFNVKTADPD;RACCDIASQHRT;SLGDVAYV;TEAHEHSLYLTAFAVIG;VGEVPVTLSAHSV 8 6.2 1.0028 -2.56 12.5835 10.3495 8.18819 7.68096 0 0 10.5857 10.7175 10.8607 0 0 7.42819 0 8.99263 0 A0A8C0SAY7 A0A8C0SAY7_CANLF PDZ domain-containing protein LOC612555 Canis lupus familiaris (Dog) (Canis familiaris) PHGAGAGA;PLETHPGKPEE 2 5.6 0.98684 -0.23043 0 0 0 0 0 8.20031 9.66973 0 0 0 9.42173 0 0 0 0 A0A8C0SAZ5 A0A8C0SAZ5_CANLF SEH1 like nucleoporin SEH1L Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; chromosome segregation [GO:0007059]; positive regulation of TORC1 signaling [GO:1904263]; protein transport [GO:0015031] kinetochore [GO:0000776]; lysosomal membrane [GO:0005765]; nuclear pore outer ring [GO:0031080]; Seh1-associated complex [GO:0035859] structural molecule activity [GO:0005198] IHDVSFDFHGRRMAT;PLDSPRAGS 2 6.2 0.98823 -0.22451 0 0 0 0 0 0 0 0 0 0 8.65392 0 0 0 0 A0A8C0SB07 A0A8C0SB07_CANLF Rhophilin Rho GTPase binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DSLTGVPAQQRALAFEKG;KRAILGQEEALRLH;LLMAYYNQLCFL;QIGARQDRSCPE;SQPWGSAWPE 5 10.8 0.93909 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.94929 A0A8C0SB31 A0A8C0SB31_CANLF Exophilin 5 Canis lupus familiaris (Dog) (Canis familiaris) ALNTPTTVSSRRSPG;DCDTDTTT;EPDLDTLQSEP;MSTLESMEVSQGNGSQSTHF;NSPPGKDPSL;SLHFPAITQNKSGFIPPRYQQSPK;SMFSVSGDEDNVKCLE;VGNSQTIRSSGECAGHGMAI 8 6.4 1.0045 -1.0466 0 0 0 0 0 0 10.3454 8.96342 8.41278 0 0 10.5497 9.08478 12.0274 0 A0A8C0SB60 A0A8C0SB60_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] intermediate filament [GO:0005882] structural molecule activity [GO:0005198] VTSPCATRPSCAPCP 1 3.3 0.99426 -0.12948 0 0 0 0 0 0 13.3849 0 0 0 0 0 0 0 0 A0A8C0SB97 A0A8C0SB97_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029] mitochondrial inner membrane [GO:0005743] ATP:ADP antiporter activity [GO:0005471] RRAARPMGAAGGGAGRGF;VLSFWRGNLANV 2 7.2 0.96417 0.048671 0 9.89392 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SBB5 A0A8C0SBB5_CANLF DIRP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634]; transcription repressor complex [GO:0017053] ALKQKRQKIRLLQQRKVAD;CLKESFPNLKTRKLTRV;GGGGAAPG;SPCSGALSK 4 6.9 1.0012 -0.70858 7.28725 7.99135 0 0 0 4.76713 0 0 0 5.58352 0 0 0 0 0 A0A8C0SBD6 A0A8C0SBD6_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;ESGGDLVKPGG;EVKLVESG;EVKLVESGG;EVKLVESGGD;EVKLVESGGDL;EVKLVESGGDLVKPG;EVKLVESGGDLVKPGG;KNTLCLHMNSL;LKGAQGEVKLVESGGD;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VSQAPWKGLQWVTWVN 18 41.2 0 12.689 10.6033 8.05279 8.7909 11.0725 9.28332 10.1153 10.4484 11.1594 11.911 9.85031 9.60829 9.89975 7.95449 9.32973 9.34236 A0A8C0SBE0 A0A8C0SBE0_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ESDEGLPCPGCCLGPFS;KGVFHRDL;PFTEITQHLEW;PVPRAPLTHNQRSVSRGGPSA 4 9.1 1.0028 -0.97945 0 0 0 0 0 0 0 0 0 0 0 0 6.47771 8.5529 0 A0A8C0SBF0 A0A8C0SBF0_CANLF Solute carrier family 22 member 23 SLC22A23 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AASPPAPAPAPWAPP;PGNASRGGADAPPL;VGRRPVLL;VGRRPVLLFSIIFILIFGLTVALS;VLPFLGGLGGGYQRT;WPHTPGLTRPRAVE 6 12.7 0.9359 0.060913 0 0 0 0 0 0 0 0 0 6.08157 0 0 0 0 0 A0A8C0SBH7 A0A8C0SBH7_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) regulation of blood coagulation [GO:0030193] extracellular region [GO:0005576]; P-body [GO:0000932] metal ion binding [GO:0046872]; serine-type endopeptidase inhibitor activity [GO:0004867]; transferase activity [GO:0016740] ELFYKAGGE;GIVAEGRNDLFVSDAFHKA;MYQEGKFRYRRV;SEAAASTVIGIAGR;SMMYQEGKFRYR;TVIGIAGRSLNPNRVTF;VDYIQNHSKKGADQQQPPQHSKYKT;YPPHYDGRRVYPAQSYTREEIFRES 8 7.1 0.99803 -0.60608 9.87203 0 0 0 10.9581 0 5.72702 3.89714 0 6.535 7.24298 0 9.06778 0 0 A0A8C0SBI2 A0A8C0SBI2_CANLF PX domain-containing protein PXDC1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] PLILRVLRVL 1 3.3 0.99978 -0.61146 0 0 0 0 5.47726 0 0 0 0 0 0 0 0 0 0 A0A8C0SBI6 A0A8C0SBI6_CANLF Acetylserotonin O-methyltransferase like Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleoside triphosphate diphosphatase activity [GO:0047429]; O-methyltransferase activity [GO:0008171] GETGPGPG;VEGGGSDPAGGI;VESPPPFP;VESPPPFPAD;VTVGGLIL 5 6.9 1.0012 -2.7148 0 0 0 0 0 8.61357 0 9.47932 0 0 9.43033 0 0 0 5.3381 A0A8C0SBJ1 A0A8C0SBJ1_CANLF Maestro heat like repeat family member 6 Canis lupus familiaris (Dog) (Canis familiaris) ASAIPPAGREPCPSPR;GPLRKLVLRSLVPLLLRLQ;IHHTCPGC;LCAWQGDREPTV;PLRKLVLRSLVPLLLRLQ;PQDPLRWAAAVL;RGPLRKLVLRSLVPLLLRL;VGLRGPLRKLVLRSLVPLL 8 10.1 1.0025 -0.77066 0 0 11.3995 0 2.61883 11.6148 10.3732 0 11.479 0 6.74295 4.67373 0 6.49235 0 A0A8C0SBJ7 A0A8C0SBJ7_CANLF Intraflagellar transport 172 IFT172 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] CGGVEQFDCCLRRSI;IKLRLLLP;LLPLEDEAESGPHFP;VGKHHPDLLSD;VRLEEAWGDHLV;YHYLEAQEWKA;YKEAGLWSD 7 4.5 1.0014 -2.676 0 0 0 0 0 7.72458 0 9.91159 6.98732 8.87464 0 0 10.2321 0 0 A0A8C0SBK7 A0A8C0SBK7_CANLF CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) CTPS1 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' CTP biosynthetic process [GO:0044210]; glutamine metabolic process [GO:0006541]; pyrimidine nucleobase biosynthetic process [GO:0019856] cytoophidium [GO:0097268]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802] LEERHRHRFEV;LVPGGFGV;TDLEPSTL 3 6.2 1.0016 -0.70038 12.1358 0 0 0 13.5547 0 8.85443 0 0 0 0 0 0 8.80274 0 A0A8C0SBK9 A0A8C0SBK9_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GAGGGGGG;GIPGKSELPYEELWL;PCPALPAA 3 3.1 0.99019 -0.21204 0 0 0 0 0 0 8.24041 0 0 10.4466 0 0 0 0 0 A0A8C0SBN8 A0A8C0SBN8_CANLF Cardiotrophin like cytokine factor 1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] CNTFR-CLCF1 complex [GO:0097059]; CRLF-CLCF1 complex [GO:0097058] cytokine activity [GO:0005125] KKKKKKKV;LHVRKKKKKKKV;LQFVVTALHVRKKKKKKK;VTALHVRKKKKKKK;VVTALHVRKKKKKKKV;WRSAKDFNRLKKKM 6 5.8 0.93459 0.099673 0 4.54306 0 0 0 3.74567 0 0 0 0 0 0 8.98735 0 7.76281 A0A8C0SBN9 A0A8C0SBN9_CANLF Ankyrin repeat domain 37 Canis lupus familiaris (Dog) (Canis familiaris) GRRHVRVF;KMQLLDCNPEVDGVQHLLEA 2 6.4 0.94983 0.049773 0 0 0 0 0 0 0 8.07698 0 0 0 0 0 0 0 A0A8C0SBP2 A0A8C0SBP2_CANLF Myotilin MYOT Canis lupus familiaris (Dog) (Canis familiaris) FNYERPKHFIQSQNPCGSRLQ;QRYCASSTV;TYEEKMARRLLGP 3 8.6 0.99437 -0.12374 0 0 10.2639 0 10.0167 0 0 0 0 9.01422 0 0 0 0 0 A0A8C0SBS5 A0A8C0SBS5_CANLF Annexin Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] ERILVCLLQG;TILCTRSATHLLRVFEE;WSPGPFSPP 3 12.5 0.99832 -0.60444 0 7.40054 0 9.05596 0 0 0 10.7245 0 0 0 0 0 0 0 A0A8C0SBS6 A0A8C0SBS6_CANLF Latent transforming growth factor beta binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; transforming growth factor beta binding [GO:0050431] CEDHDECQDMACE;CEDVDECEDL;CEDVDECEDLQ;CIDIDECANDTMCGSHGFCD;EDHDECQDMACENGEC;FCSPPLTLDL;GGRCTNTEGSYHCQC;GLNLTEKIKKIKIVFTP;HDECQDMACENGECVNT;HYNAVHRKCEDHDE;IDIDECANDTMCGSHGF;IDIDECANDTMCGSHGFCDNT;LGHTCEDVDECEDLQS;PTGDCIDIDECANDTMCGSHGFC;QAECCCTQGASWGDTCDPCPAED;RCVNSTGAQVSRPGMV;SYHCQCDQ;TTQAECCC 18 9 0.99163 -0.041334 0 0 0 0 0 0 0 0 9.93452 0 0 0 0 0 0 A0A8C0SBS8 A0A8C0SBS8_CANLF Y+L amino acid transporter 2 (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] VIWAIGGLFS;YSALFSYSGWDTL 2 4.5 1.0031 -0.79693 5.1469 0 0 0 0 0 0 5.52985 10.448 0 0 0 0 0 0 A0A8C0SBX9 A0A8C0SBX9_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor signaling pathway [GO:0050852] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DPAATPVA;DSDESSDDDSDSEE;EHDSDESSDDDSDS;ESSDDDSDSEETSR;GGVGGALS;GTYIGIDAMLEGLE;LIIFLVFLIIVTFLALLVVL;NKNRYVDILPYDYN;PAQNGQIKKSNNKDDKVEFAN;PGGGVGGA;SHSSCDSPNKT;YRSWRTQHVGNQEQNKSKNRNSYI 12 10.2 0.98495 -0.24653 0 0 0 0 0 9.25406 0 0 0 0 0 0 0 0 0 A0A8C0SBY8 A0A8C0SBY8_CANLF Glutamate ionotropic receptor NMDA type subunit associated protein 1 GRINA Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic signaling pathway [GO:2001234] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] GALLFTCFLAVDTQ;PADPAPPRPR;VSPAAGPA 3 8.4 0.98846 -0.30805 0 0 7.23016 7.14109 7.32319 0 0 0 0 0 12.4238 9.88364 0 0 0 A0A8C0SC00 A0A8C0SC00_CANLF glycerol kinase (EC 2.7.1.30) GK Canis lupus familiaris (Dog) (Canis familiaris) glycerol catabolic process [GO:0019563] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" IPVVKPSMPETTALGAA;KLAKEVGT;KPSMPETTALGAAMAAGAAEGVGVW;TNASRTMLFNIHSLEWDKELCE 4 11.2 0.9865 -0.42014 0 0 0 8.86879 0 0 10.225 0 8.00501 0 0 0 0 0 0 A0A8C0SC02 A0A8C0SC02_CANLF Methyl-CpG binding domain protein 1 CFAP53 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ACTRTSWNQRGWPRTH;DCGHCDFCCD;VGCGECAA 3 5.8 0.96262 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 9.9857 0 A0A8C0SC08 A0A8C0SC08_CANLF Rho guanine nucleotide exchange factor 37 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] EDKEFDDLEERFHWVSL;IDDVIEVNNRFLHD;VTPSQEEVRGQE 3 6.8 0.85048 0.15761 0 0 0 0 0 6.14991 0 0 9.69194 9.72552 0 0 0 0 0 A0A8C0SC29 A0A8C0SC29_CANLF PNPLA domain-containing protein PNPLA5 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] hydrolase activity [GO:0016787] STWARFCRS;YFPFYCGIIPPEF 2 6 0.98724 -0.5031 0 0 9.70587 0 7.12133 0 0 0 0 0 0 0 0 0 0 A0A8C0SC48 A0A8C0SC48_CANLF Ornithine decarboxylase antizyme 1 OAZ1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] spliceosomal complex [GO:0005681] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AEGKFWTHWN;APGIHPQPPGVHPPPPGVHPSA;IDKAEGKFWTHWN;KAEGKFWTHWNRETKQFFL;PGVHPPPS;PRHRFMSAYEQRIEPPDRRWQ 6 15.5 0.98501 -0.43764 0 0 0 0 0 0 0 9.89889 0 0 8.51179 0 0 0 10.3908 A0A8C0SC49 A0A8C0SC49_CANLF Acid sensing ion channel subunit 2 ASIC2 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280] APFCTPEQHKECAEPALGLLAEK;FSMLEFLHRVGHDLKDMLLYC;LGKEEDEGSHDE;QTFVATQE 4 12.5 0.9778 0.047591 0 0 0 0 0 0 0 0 8.75091 0 0 0 0 0 0 A0A8C0SC78 A0A8C0SC78_CANLF Protein inturned (Inturned planar cell polarity effector homolog) Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; establishment of planar polarity [GO:0001736]; vesicle-mediated transport [GO:0016192] cell surface [GO:0009986]; cytoplasm [GO:0005737] IAIYCRHYCLLP;KAKEQLKLLEVLVGIIHQT;NEIIIEEDYKE;TSSPSPCL;TYETLRYIM 5 6.9 1.0021 -1.2988 7.5131 0 0 5.57843 9.70522 6.61602 0 0 0 0 9.25602 0 0 0 0 A0A8C0SC83 A0A8C0SC83_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] HAARKAYHFFKRNPHPDA;PSAALRHPFVS;VPDSGPEP 3 6 0.98674 -0.50024 0 0 0 0 0 0 0 0 0 0 0 0 9.56425 0 8.90135 A0A8C0SC85 A0A8C0SC85_CANLF Protein kinase C and casein kinase substrate in neurons protein 1 PACSIN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; regulation of endocytosis [GO:0030100] cell projection [GO:0042995]; endosome [GO:0005768]; plasma membrane [GO:0005886] phospholipid binding [GO:0005543] GFCSSGAA;KRWRQLIEKGPQ;VFEQCQQFE 3 5.8 0.99047 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 10.973 0 A0A8C0SC86 A0A8C0SC86_CANLF G-patch domain and KOW motifs-containing protein GPKOW Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634] nucleic acid binding [GO:0003676] DPDNVRAMVRLAVGN;GCIPNGEGADSEPRAETVP;GEGADSEP;HYDAVCQYMGPSDS 4 9.9 1.0034 -1.5219 0 0 0 8.46695 0 0 9.82717 9.49259 0 0 0 0 0 0 0 A0A8C0SC88 A0A8C0SC88_CANLF von Willebrand factor A domain containing 7 Canis lupus familiaris (Dog) (Canis familiaris) DLTEEAALNVT;LLLLLLLL;LLLLLLLLL;QARHIVEQRR;SHLSTSLLL;SSLSFVLDTT 6 5.2 1.004 -1.9901 9.56898 0 0 0 0 0 0 0 9.27929 0 0 0 0 0 0 A0A8C0SC98 A0A8C0SC98_CANLF Anti-Mullerian hormone AMH Canis lupus familiaris (Dog) (Canis familiaris) gonad development [GO:0008406] extracellular region [GO:0005576] growth factor activity [GO:0008083] AAHQPVGGAHQRAP;GAGGGGGG;GGGGGGGA;GGGGGGGG 4 3.7 0.98351 -0.2444 0 0 0 0 0 0 0 0 0 0 0 0 9.02489 0 0 A0A8C0SCA2 A0A8C0SCA2_CANLF Zinc finger BED domain-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983] AEPEDEDEG;LFGSSANV;LVEYFQQSTVAMYMLYEKQKQ;MLQRLKEQQFV;NQNRAYVTLAAH;SLATKAGHGHE 6 10.7 1.0018 -2.6428 0 0 8.15851 0 6.14814 7.60266 0 10.1098 0 0 0 7.01881 0 0 0 A0A8C0SCA8 A0A8C0SCA8_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886] actin filament binding [GO:0051015] AQVSAHGAHVHHLALQT;DLRGLEAQ;EQTVQRRLAKILLQL;FSRLHQEQTVQRRLAK;GVWAQLHSEE;ILQQEQHHDWADVAI;LQASVGLYQFYQLSNLELTWVAEH;NSRWKSFHGNL;PAGGGGAG;QAWERQEEKLQTVHREQLF;QIRKHKELERD;SLRHKHEELQVEVKAHQ;VLSSVEQMESWL;VQQEGQQLIDSGHFMSLEVAGCL;YYHHFSRLHQEQ 15 5.5 1.0048 -1.0505 0 0 0 0 0 0 0 0 0 6.80142 0 0 0 0 0 A0A8C0SCB0 A0A8C0SCB0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;DKGLVSKIYKELIKLNTKKKKKKK;KKKKKKKK;KKKKKKKKKKK;KKKKKKKKKKKNKLN;KKKKKKKKKKN;KKKKKKKN;KLNTKKKKKKK;KLNTKKKKKKKKKKKNK;KLNTKKKKKKKKKKKNKLNTKETN;LVSKIYKELIKLNTKKKKKKK;MDAFLESHKL;MNEKGEITTNT;NTHVRKCSASL;NTKKKKKKKKKKKNK;RLQIARGILKKKTISG;TKKKKKKKK;TKKKKKKKKK;TKKKKKKKKKK;VIKTVWYWHRNRHIDQ;VSKIYKELIKLNTKKKK;VSKIYKELIKLNTKKKKKK 22 15 0.80519 0.22023 6.56186 6.13592 0 0 0 0 10.9557 10.9592 9.6067 0 7.12794 0 6.52615 0 8.08215 A0A8C0SCC0 A0A8C0SCC0_CANLF Small ribosomal subunit protein eS10 (40S ribosomal protein S10) RPS10 Canis lupus familiaris (Dog) (Canis familiaris) cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] CGLRFQPVGRGSGWS;KEQFAWRHFYW 2 7.2 0.98477 -0.23784 0 0 9.59723 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SCD0 A0A8C0SCD0_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) GAPRAGGG;RGPAAPPAA;SSSGGGGH;SSSSGGGG 4 5.6 1.0028 -1.9086 9.45436 0 0 0 0 0 0 0 0 0 0 0 8.68401 0 0 A0A8C0SCD5 A0A8C0SCD5_CANLF Ceramide synthase 2 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] DDGRVYAK;ILHCTIVYPLELYPAFFG;YDMKKVWEGYPIQSTIPSQYWYY 3 12.9 0.99229 -0.16715 0 0 0 0 0 0 11.7932 0 0 0 0 0 0 0 0 A0A8C0SCI4 A0A8C0SCI4_CANLF "Zinc finger protein, FOG family member 1" Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] EAAGAATPEAEAEAEG;PSPGLDRKALTEA;SASAATRPTRCTSATTAP 3 4.8 0.98525 -0.23762 0 0 0 9.23647 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SCK3 A0A8C0SCK3_CANLF Ornithine decarboxylase antizyme 1 OAZ1 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245]; viral translational frameshifting [GO:0075523] catalytic step 2 spliceosome [GO:0071013]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004] nucleic acid binding [GO:0003676]; ornithine decarboxylase inhibitor activity [GO:0008073]; zinc ion binding [GO:0008270] AEGKFWTHWN;GGALPEGSKDSFAVLLE;IDKAEGKFWTHWN;KAEGKFWTHWNRETKQFFL;PRHRFMSAYEQRIEPPDRRWQ 5 11.2 0.5419 0.44193 0 0 0 0 11.597 0 0 0 0 0 0 0 0 0 0 A0A8C0SCK7 A0A8C0SCK7_CANLF Solute carrier family 45 member 2 AMACR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate transmembrane transporter activity [GO:0015144] EDKERGLHYHAF;EFLIYERGVEVGCWGLCINSV;GRVLGSEFQVMFFFSAL;HLEIGRVLGSEFQV;LVSYIGLKGLYF;TCKSLAEDDHFDPV;VGGSASDNCQARWGRRRPYI;YHGDPYSA 8 20.5 1.0035 -1.6373 11.7073 8.0511 0 0 0 10.3793 8.80613 7.84712 0 0 0 0 0 11.9745 11.248 A0A8C0SCM9 A0A8C0SCM9_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CQCCEEKPAIMVSNLHKEYED;DISDLISFFTNQNIMV;IMVSNLHKEYEDKKD;KEHLQKTIKKL;KRESKSVRSVLLLLLIFFAVQ;MLGSLFAFHYGLY;SNLTEGPYPLI;VIQEVQKVL 8 6.4 1.0032 -1.1127 0 4.29116 7.75395 0 9.90883 9.75667 0 0 0 0 10.4267 7.75722 9.26562 6.58762 0 A0A8C0SCN1 A0A8C0SCN1_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoderm development [GO:0007492]; hematopoietic progenitor cell differentiation [GO:0002244] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]" APALPALPAPPPGPAA;KSRRQSGKSF 2 12.4 1.0032 -0.88116 5.07412 0 0 0 0 0 12.2416 0 0 0 0 0 0 0 0 A0A8C0SCN7 A0A8C0SCN7_CANLF Bromodomain adjacent to zinc finger domain 1B Canis lupus familiaris (Dog) (Canis familiaris) WICH complex [GO:0090535] histone H2AXY142 kinase activity [GO:0140801]; metal ion binding [GO:0046872] ASEDSEDDESEEEEEE;ELKEKLKEKAKERRE;ESASEDSEDDESEEEE;ESEEEEEEEEEEV;ESEEEEEEEEEEVEEEDYE;ISAVKSRR;LRLRPRKTVRGKQ;SDKENSSQIAQD;SEEEEEEEEEEVEEEDYE;SGKHSDKPLKAK 10 7.3 1.0025 -1.1455 9.15388 0 9.03958 10.9291 4.32905 0 0 0 5.06596 0 0 12.1067 7.90195 12.517 11.2182 A0A8C0SCP9 A0A8C0SCP9_CANLF Fibroblast growth factor binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor binding [GO:0019838] CVFTGNPTFCLESNKKNVY 1 8.4 0.95192 0.049853 0 0 0 0 0 0 0 0 0 0 8.86152 0 0 0 0 A0A8C0SCQ2 A0A8C0SCQ2_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) retrotransposition [GO:0032197] membrane [GO:0016020]; ribonucleoprotein complex [GO:1990904] single-stranded RNA binding [GO:0003727] LFFFLFSFFFFSFHSFSLS;LKEHVTSKPAL;SETVLSPTELQNLD;SLFFFLFFFSFFLFFFLFS;VLRTRVNEVEER 5 18.8 1.0023 -0.66517 0 9.78141 0 0 0 0 0 12.0075 0 0 9.41876 9.4068 0 0 0 A0A8C0SCQ7 A0A8C0SCQ7_CANLF Solute carrier family 45 member 2 AMACR Canis lupus familiaris (Dog) (Canis familiaris) bile acid metabolic process [GO:0008206] mitochondrion [GO:0005739] alpha-methylacyl-CoA racemase activity [GO:0008111] SSRTEFIRWW 1 5.1 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 11.6504 0 0 0 0 A0A8C0SCR2 A0A8C0SCR2_CANLF Ig-like domain-containing protein MOG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CHRAGSRRASP;GVSALTGPGSPSHRR;LVVIAVLPVLLLQI;NGCSCWSCWECEQ;NLHRTFGQFLEELTPG;TGMEVGWYRP 6 26.1 1.0018 -0.67416 0 0 6.6851 0 0 6.15947 0 7.47387 0 2.95503 3.70962 7.47565 0 0 0 A0A8C0SCR9 A0A8C0SCR9_CANLF BAR/IMD domain containing adaptor protein 2 like 1 BAIAP2L1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane organization [GO:0007009]; regulation of actin filament polymerization [GO:0030833] GGGGGGGG;HLHYYHLQSAELLNSKLPRW;TYRNVMEQFN;VATGLNMM 4 8.5 1.0024 -1.3723 0 7.75215 0 0 0 0 0 0 10.056 0 0 0 0 0 0 A0A8C0SCT7 A0A8C0SCT7_CANLF "Unc-80 homolog, NALCN channel complex subunit" UNC80 Canis lupus familiaris (Dog) (Canis familiaris) CNQQSFICTHVDYCHP;DTEVQGAPAHSP;EDSKDSLHSSS;GDGGGEEGGGGDGGGGGGD;GDGGGGGG;GGDGGGGG;GGGDGGGG;GGGGDGGG;GGGGGDGG;GGGGGGDGGG;GGGGGGGG;GGPYEKNDKNQE;GVEDLLDISSVDR;ISEEHGMENPL;ISLRKKLKLPIGKR;LALWDFLDFIV;LRKKLKLPIGKRNW;LRKKLKLPIGKRNWLKRSSL;LVSDLPDHSNS;QQPLGRKRGLRQLRRPLLSRQKT;RKPFVLQLFAS;RKSSEGQEQDGGR;RSRSRRISLRKKLKLPIG;SLEGETTDILDILEL;SRRISLRKKLKLPI;VARAALFLECARFVHR;VGRVLFLISLTQKIPTAH;VRPALILILK 28 8 0.99697 -7.3297 9.40867 9.71577 8.86391 7.79837 6.36235 7.57372 9.2341 11.8219 10.4236 6.01647 9.0568 11.6914 6.29818 9.51426 9.12055 A0A8C0SCU3 A0A8C0SCU3_CANLF sphingomyelin phosphodiesterase (EC 3.1.4.12) SMPD2 Canis lupus familiaris (Dog) (Canis familiaris) sphingolipid metabolic process [GO:0006665] membrane [GO:0016020] sphingomyelin phosphodiesterase activity [GO:0004767] CRLLKECTGLHDA;HRGDRMKRLGDL;VYLFHMQEAK 3 8.3 1.0028 -0.87014 3.95559 0 0 0 0 0 3.63366 5.23235 4.71534 0 0 10.4944 5.25852 11.2487 11.0877 A0A8C0SCU4 A0A8C0SCU4_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) AREL1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630] DISVSDFKAHAV;PTNNSASLRDE;QEVLQEPRSNVVK 3 4.7 0.98832 -0.26067 0 9.84108 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SCV5 A0A8C0SCV5_CANLF Family with sequence similarity 111 member B Canis lupus familiaris (Dog) (Canis familiaris) ILFHVVAVGKSIKKILKIK;PLKTKHISHQAILQ;STVCVYALKGETI;VGKSIKKILKIK;VGMQHVINQ;VGMQHVINQT;YAEQLQDEMFCHSLECRS 7 9.9 1.0023 -0.90103 7.03485 0 10.3703 0 6.45709 0 0 0 5.39153 8.43613 0 0 6.18367 0 0 A0A8C0SCX8 A0A8C0SCX8_CANLF "GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)" AK3 Canis lupus familiaris (Dog) (Canis familiaris) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041] mitochondrial matrix [GO:0005759] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899] DDRPETLNQ;GDGAGQERGGG;QSSKSLMR 3 7.5 1.0025 -0.79109 0 11.4507 0 0 0 0 0 0 0 11.3204 0 0 0 0 0 A0A8C0SCY2 A0A8C0SCY2_CANLF Peptidase S1 domain-containing protein LOC479649 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DAVPGSWPWQVSL;GDSGGPLVCQKDGA;LVGIVSWGSGWCN;PAGSLCATTGWGRTRYNSNKTPD;SGGPLVCQKDGAWTLVGIVSWGS 5 24.7 0.99264 -0.28219 0 0 0 9.11702 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SCZ5 A0A8C0SCZ5_CANLF CUB domain-containing protein ST14 Canis lupus familiaris (Dog) (Canis familiaris) AASAQRCPR;YPGHYPPNMNCTW 2 7.4 0.98455 -0.25303 5.51583 0 0 0 0 0 0 0 0 0 0 0 0 9.80668 6.20322 A0A8C0SCZ6 A0A8C0SCZ6_CANLF FRY like transcription coactivator FRYL Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902] AAGRNGKP;EDALLLRAGTPSLE;EEADFSGLSSQDEEEQ;ETPIIGNKYGDQHSAA;EYLLALRLLNKLLIH;IAASLLESDYEY;IIVLIIRVLLFLLLLASA;IKENIEESYAHLDIYSG;KDTASRIAKVCAEE;LDVELEDAE;LIIRVLLFLLLLASAPVSKV;LIIVLIIRVLLFLLLLA;LIIVLIIRVLLFLLLLASAPV;LLIVMGSNSNIRTV;LNIFVKIIQ;PERMNIGLRVF;PSLLPYVKKV;SKHTLVDPSQLSGFP;TFGAKGDLYRINTDAQVINM;TLALKELDERCEEEEADFSGL;VLIIRVLLFLLLLA;WMFAYTRLQSLSP 22 8.2 0.99947 -2.8744 4.21467 8.01463 8.98225 0 10.4674 8.02763 7.62826 10.339 11.0634 8.95702 9.52623 0 10.2621 11.2028 9.27796 A0A8C0SCZ9 A0A8C0SCZ9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TNLIHEGS;WWKAGFLFEGTN 2 27.7 1.0042 -1.0539 0 0 0 10.8969 7.75094 0 0 0 0 0 0 0 0 0 7.09592 A0A8C0SD05 A0A8C0SD05_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor signaling pathway [GO:0050852] membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DPAATPVA;DSDESSDDDSDSEE;EHDSDESSDDDSDS;ESSDDDSDSEETSR;GGVGGALS;GTYIGIDAMLEGLE;HHKNVPLLIHCRS;LIIFLVFLIIVTFLALLVVL;NKNRYVDILPYDYN;PGGGVGGA;SHSSCDSPNKT;YRSWRTQHVGNQEQNKSKNRNSYI 12 10.5 0.99903 -3.1335 0 9.82303 8.22709 0 8.9851 0 8.81237 4.01391 10.7819 0 8.24127 0 10.0786 6.78856 0 A0A8C0SD28 A0A8C0SD28_CANLF Derlin Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; proteasomal protein catabolic process [GO:0010498] Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839] misfolded protein binding [GO:0051787]; ubiquitin-specific protease binding [GO:1990381] FGTRFKACYLPWVI;FPVGPGTGFLYLVNLYFL 2 15 0.97239 0.048313 0 0 0 0 8.80581 0 0 0 0 0 0 0 0 0 0 A0A8C0SD34 A0A8C0SD34_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) establishment of skin barrier [GO:0061436] cornified envelope [GO:0001533]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] DTESHSGVPQAHSGSPRGQAGS;GSGQSSGCGHGSGSCQ;GVPQAHTGFPQ;GVRQSHSGSP;KQDGECGTLSKDELKELLEKEF;PESSLFRSTRIY;SRSQGIIFSHS;TESGHGQATRT 8 3.7 1.0013 -0.93604 0 0 0 5.6041 0 0 6.56175 0 0 0 9.65439 0 5.56879 0 10.1398 A0A8C0SD55 A0A8C0SD55_CANLF SHC adaptor protein 2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] FTQLGGHP;GGHPGDPYTHPH;RPLQPPRTRP 3 2.6 1.0027 -0.84875 0 0 0 0 0 0 0 0 12.1245 0 0 0 10.4261 0 0 A0A8C0SD57 A0A8C0SD57_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ANKGGGGA;ATSPVLLPALPRRTPK;CIICHRVLSCQSAL;DNFSDENMEDCP;DNIPTSTGIPYGM;GGGGGGSG;GILFPFRDRGKFK;GPGSATAF;PEHLDNIPT;SPAADGGP;VLQQHIRMHMGGQIPNTP 11 10 1.0015 -2.6492 0 0 0 0 8.33891 0 9.25167 0 0 0 0 10.7046 8.92487 9.58624 10.4084 A0A8C0SD61 A0A8C0SD61_CANLF Keratin associated protein 16-1 KRTAP16-1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CQGSCESSSCGPQCCQ;EPSCSEPSSCQPATC;LVCEPVCLRS;LVTCQGSCESSSCGPQCCQP;PSCSMNSCAQPVCCEA;PVCCEATICEPSCSVSSCC;VPRPCQPPCYVVKRC;VTSISYRPACY 8 19.1 1.0023 -0.66504 0 0 0 0 0 9.1035 0 0 0 5.75822 0 0 0 0 9.75467 A0A8C0SD65 A0A8C0SD65_CANLF Proteolipid protein 2 LOC480914 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YSSLSVVEMILAA 1 8.9 0.99049 -0.14617 0 0 11.4107 0 0 0 0 0 0 8.93449 0 0 0 0 0 A0A8C0SD75 A0A8C0SD75_CANLF Potassium two pore domain channel subfamily K member 12 KCNK12 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] potassium channel activity [GO:0005267] CCCCCRRSHLNE;VISILIKQVL 2 5.1 0.99447 -0.56102 0 0 0 0 8.77251 3.49838 0 0 0 0 0 0 0 0 0 A0A8C0SD78 A0A8C0SD78_CANLF RAD50 interactor 1 RINT1 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Dsl1/NZR complex [GO:0070939] DFEEILAQL;LVEKLDVYIYQEI;NVPEAASTL;TQVMKEESRASLGFRYCAILNAVNY;TRNLFPLFSHY;VGNEQVNEDTDN 6 9.9 1.0045 -1.0443 0 3.51501 0 0 0 0 0 0 12.4821 0 0 0 0 9.32562 0 A0A8C0SDA1 A0A8C0SDA1_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] WQQRFMSKDVRLPMT 1 6.9 0.94906 0.053909 0 0 7.1235 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SDA4 A0A8C0SDA4_CANLF "Spectrin alpha, non-erythrocytic 1" SPTAN1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516] DLQLFYRDTEQVDNW;EDKVKALCAEADRLQ;EPDPEFEAID;FEEFQTDMAAHEERVNEVNQFA;GEPDPEFEAI;HEAFETDFTVHKDR;IRVYQYEVGDDL;ISWIKEKEQL;KKFDDFQKDL;LDGIAYRRV;QEQHPEEETI;QKKFEEFQTDMAAHEE;QVDNWMSKQEAFLLNEDLGD;QYEQCMDLQLFYRDT;SYRFQFFQRD;TNVQNLQKKHAL;VEEEEAWINEKM;VGLAQQWDQL;YRDTEQVDNWMSKQEAFL 19 7.8 0.99951 -2.8674 4.78194 11.5614 0 12.2442 11.1307 0 0 0 9.33642 11.4581 0 10.2124 11.0727 8.94243 7.2571 A0A8C0SDA7 A0A8C0SDA7_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EEDAFWALAQLMTDRHAMHGRGA;VQLLPQRW 2 8.9 1.0036 -1.0579 0 0 3.4734 0 0 0 0 9.76515 0 0 0 0 0 0 0 A0A8C0SDC2 A0A8C0SDC2_CANLF Ankyrin repeat domain 13D ANKRD13D Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ARPARPPRRLRRRRRRRRR;RPARPPRRLRRRRRRRRRRH;THLDTRNVAFERNK 3 5.3 0.9729 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 6.10706 0 A0A8C0SDD6 A0A8C0SDD6_CANLF Orange domain-containing protein HELT Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] PFPWPHGP;PGAGPPQRPARRSAHN;PSAPVPLPSPAQ;SAPVPLPSPAQP 4 12.8 1.001 -0.62145 0 0 12.7983 0 0 0 14.5438 9.59943 0 0 9.18123 0 0 14.4806 0 A0A8C0SDI4 A0A8C0SDI4_CANLF Ankyrin and armadillo repeat containing Canis lupus familiaris (Dog) (Canis familiaris) AAGRGWLPIHFAAFYD;AFQIDVKEQGA;ESYKRRMMAVMSLE;FSDDKVKTERELPP;GLVDITKDPDFNG;GNEQNQRAV;KGLPRFDQTQDEE;LFAFNNRLQQY;LINVMNCIRVLCMGNEQNQRAVRDH;VGLLSNLST 10 8.8 1.003 -1.523 0 0 6.89336 9.50881 0 0 0 9.3103 10.4552 8.73789 0 0 0 0 10.7189 A0A8C0SDK0 A0A8C0SDK0_CANLF SET nuclear proto-oncogene SET Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDEEE;DDEEGEGEEDDDDDEEEEGLE;DMDDEEGEGEEDDDDDEE;DMDDEEGEGEEDDDDDEEE;EDDDDDEEE;EDDDEGEEG;IDEEGDEDEGEEDEDDDEGEEGE;LEDIDEEGDEDE;LVKSKRDHLKRILLFCGLHL;MDDEEGEGEEDDDDDEEEEGL 10 21.3 0.97312 0.048206 0 0 0 0 0 0 0 0 0 7.2363 0 0 0 0 0 A0A8C0SDL4 A0A8C0SDL4_CANLF R3H domain containing 2 R3HDM2 STAC3 Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383] metal ion binding [GO:0046872] PGFQQSHYFVAL;PGFQQSHYFVALYRFKA;PIYYIYEEEEEEEEEEE 3 9.4 0.97877 0.046227 0 0 0 0 0 0 0 0 8.37886 0 0 0 0 0 0 A0A8C0SDL6 A0A8C0SDL6_CANLF Solute carrier family 12 member 9 SLC12A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] chloride:monoatomic cation symporter activity [GO:0015377] NMSGELKDPSRA;QVLPQGYGWSL 2 3.6 0.99107 -0.18588 0 0 0 0 0 4.07776 0 0 0 0 0 9.58385 9.56495 0 0 A0A8C0SDQ5 A0A8C0SDQ5_CANLF XPG N-terminal domain-containing protein GEN1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518] ESDNMMSFQSQMNLNPTC;GVNDLWQILEPV;HNMSAIADLHLS;MEGEPPKLKAD;NRYCEPHDYEYCCPCDWHRTQHER;SKLSLEITPD;VCLDRHSSNEESVPVFE;YEYCCPCD 8 12.2 1.0035 -2.05 6.97682 0 0 7.3249 0 0 0 0 10.8686 12.5795 0 8.88197 0 0 8.13704 A0A8C0SDR0 A0A8C0SDR0_CANLF FAM194 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DVEEDVEEGEEEEEEVEEG;DVFSDDDSSEPTGACCCSYSQNL;FSDDDSSEPTGACCCSYS;GACCCSYS;SSEPTGACCCSY 5 6.3 1.0021 -1.2442 0 0 7.34589 0 0 0 0 0 3.95503 10.1259 0 5.52754 0 0 0 A0A8C0SDT0 A0A8C0SDT0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;VGKRRRELIKIRAELNKI 4 5.1 0.97311 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.01903 0 0 A0A8C0SDT6 A0A8C0SDT6_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CGKSFNRSSNLVQHQSI;IQHQSIHTGEKPYECKECGKTFR;KPYECKECGKTFRLSSVFTAHQ 3 7 0.8776 0.14059 0 0 0 0 0 0 0 9.45826 9.33049 6.24531 0 0 0 0 0 A0A8C0SDU0 A0A8C0SDU0_CANLF Tripartite motif-containing protein 26 (Zinc finger protein 173) Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DEEEEGEEEEEEEEEAGYGDGYDDW;EKLHYYCEDD;LPDPGGAPGSPAPTL;SCHGNGGL;SGYLQLSEDWKC 5 11.7 1.0034 -1.5617 5.12135 0 0 0 0 0 0 2.40089 0 8.54021 0 0 0 7.7137 6.80916 A0A8C0SDW0 A0A8C0SDW0_CANLF phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) PFAS Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642] ALDSWDLDFYTKRFQE;ARPLEVAIEASNGASD;ELGLALDSWDL;LAVAEALTNLVFALVT;LPGEGAALADACEAMVAVMAALG;PGSLVISAYAVC;VPAPGVDA;YVHPSGHERAASEHTQ 8 8.3 0.9948 -0.018746 0 6.36872 8.26721 0 9.1713 9.02231 0 6.4818 0 10.6953 10.3784 0 10.5567 0 8.037 A0A8C0SDW5 A0A8C0SDW5_CANLF Sulfotransferase (EC 2.8.2.-) SULT4A1 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] AEALPVGRGRVGLWKDIFTVS 1 7.4 0.95115 0.049679 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.03837 A0A8C0SDX1 A0A8C0SDX1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CLSLFFIFTWQ;DQPPELPEELEIS;ELPQIPEEGEP;GVQVTVTPEPTTE;IHVKSGNPFT;NNKLILAISVTVVVMILIIV;PSSTQQEAPTQY 7 10.3 0.98739 -0.39878 0 0 0 0 0 8.12459 0 0 0 0 9.41124 0 0 9.61546 0 A0A8C0SDX6 A0A8C0SDX6_CANLF RB transcriptional corepressor 1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] ESLAWLSDSPL;GVRSLDTAPPP;KDLPHAVQ;QPSENLISYFNNCTVNP;RGGGSAGA 5 4.5 1.0021 -1.2425 0 0 12.2907 0 8.92947 0 3.29489 0 0 0 0 0 0 0 0 A0A8C0SDY5 A0A8C0SDY5_CANLF Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) Canis lupus familiaris (Dog) (Canis familiaris) glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] glutathione transferase activity [GO:0004364] AATRRCEAMRMLLADQGQSWKE;RRCEAMRMLLADQGQSW;SLGLYGKDQQEAA;WKEEVVTMETWMK 4 22.2 1.0037 -0.82411 7.7303 7.91031 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SDY9 A0A8C0SDY9_CANLF Glutamate receptor GRIN1 Canis lupus familiaris (Dog) (Canis familiaris) glutamate receptor signaling pathway [GO:0007215] NMDA selective glutamate receptor complex [GO:0017146]; postsynaptic membrane [GO:0045211] transmitter-gated monoatomic ion channel activity [GO:0022824] DKTWVRYQECDSRSN;DPRLRNPSDKFIYA;GDRKFANYSI;YLLDRFSPFGR 4 5.5 1.0027 -1.1428 0 10.3622 0 0 0 0 0 0 11.3148 0 0 10.8711 0 0 0 A0A8C0SDZ3 A0A8C0SDZ3_CANLF SAM-dependent MTase RsmB/NOP-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA methylation [GO:0001510] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] SSDDAIDYFKRQ 1 2.6 0.98834 -0.22746 0 0 0 0 0 0 0 0 0 0 0 9.3192 0 8.96055 0 A0A8C0SE02 A0A8C0SE02_CANLF Integral membrane protein 2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] AVAVDCKMEYLTWL;EVVPVGQRRAWC;GVILGGAYLYK;ISVPVPEFADSD;ITDRIENIDHLG 5 22.8 0.85299 0.158 8.22959 7.76288 3.11517 0 0 0 10.1202 0 8.4121 0 0 0 0 0 9.1724 A0A8C0SE23 A0A8C0SE23_CANLF Glutamate rich 1 Canis lupus familiaris (Dog) (Canis familiaris) GIRVLGEGYEEDGARV;SGEDVKNTNEKADD;SGVGCCGG;VLPVCRVCTHPKL 4 9.4 1.0033 -1.5222 9.38506 9.2261 0 0 0 14.6353 0 0 0 0 0 0 0 0 0 A0A8C0SE30 A0A8C0SE30_CANLF N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB catalytic subunit) Canis lupus familiaris (Dog) (Canis familiaris) NatB complex [GO:0031416] peptide alpha-N-acetyltransferase activity [GO:0004596] KAEGSVAREEWHG;SESKGGFFVDL 2 14.8 0.97863 0.035491 9.26113 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SE39 A0A8C0SE39_CANLF "Polycystin 2 like 2, transient receptor potential cation channel" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] FKSAYFKSVWNWLE 1 2.7 0.99098 -0.1944 0 0 0 0 0 0 0 10.1522 0 0 0 0 0 0 0 A0A8C0SE57 A0A8C0SE57_CANLF MIER family member 2 MIER2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GVASCLTHSLCPG 1 2.4 0.93973 0.059587 0 0 0 0 0 0 0 0 0 0 0 0 0 9.83873 0 A0A8C0SE76 A0A8C0SE76_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" GTASTRTGAGKFCRASTRTRGS 1 5.7 0.97527 0.046883 0 0 4.60069 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SE80 A0A8C0SE80_CANLF Cullin-5 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] Cul5-RING ubiquitin ligase complex [GO:0031466]; SCF ubiquitin ligase complex [GO:0019005] protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625] AECQGMIKRNETE;EEHIISAGL;EENEGIVQLRILR;FTEGTLFSVNQEFSLIK;GLADMVAAAETITTAY;ISADSEIEENMV;VLLYEPQVNSPKD 7 12.2 0.96365 0.049233 0 0 8.43579 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SE87 A0A8C0SE87_CANLF FAT atypical cadherin 4 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CELNSYGFEELSYMEFP;CVPPGDCA;DGLQSSDMRINITV;DLNSNISYLITTGD;DQGRPPRSSTMSVVIHVRDFNDNPS;DSDSHESFTCSEMEYDREKPM;EGACTHSP;EKTPTYSLTVQ;EVEYLISNENHF;EVTPQYQLLVEVED;FTPVTKNVKVGTKLIKVT;GSGTYKLTT;GVNSLEIKFRTRSENGILIH;ISIEAASPRGSE;IVDRYSGDLRVASALVPSQ;KEERVSLKV;LLSTGPATNYF;LSASGELRVIQSLD;MDADEGANALVTYTI;NGASEVTFSVHVKDG;PAPFSKSSTFYRNSP;PLNREDTDRYRIRVSAHDSGWTVS;QPALSSSTEVVVMVLD;QSPMPLGASSL;RRGHVESH;SSVNYCECNPCFNGGSCQ;SVASSLISDLNQNFL;SVNYCECNPCFN;TELTIILQ;TTIMAADPDEGANGEV;VGSSVLQV;VSNVAVSDD;YIKSELDRELQD 33 9 0.97523 0.035538 0 0 0 0 0 0 0 0 8.89057 0 0 0 0 0 0 A0A8C0SE88 A0A8C0SE88_CANLF TGF-beta activated kinase 1 (MAP3K7) binding protein 3 TAB3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130] DLLQSREHLTGSKQ;LHQRARMERLAKQL;PWNCDSCT;QPRDEDYEGAPWNCDSC 4 7 0.93433 0.065735 0 0 0 0 0 0 0 0 9.41543 0 0 0 0 0 0 A0A8C0SEA4 A0A8C0SEA4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] AQGCGSNCCQPCCQPTC;CCGSSCCEPCCC;CCGSSCCEPCCCLP;CCGSSCCEPCCCLPTCC;CCQPTCCGSSCCEPCCCLP;CCSPCCQPTCCGSSCCEP;CCSPCCQPTCCGSSCCEPCCC;CEPCCCLPTCCHTTSCRTSSCKPT;CGSNCCQPCCQPTCCQ;CGSSCCEPCCCL;CGSSCCEPCCCLPTCCHTTSC;CHTTCCRTTCCNCCSTPCSQPACCT;CQPTCCGSSCCEPCCCLP;CQPTCCGSSCCEPCCCLPTCC;CRPTCCHTTCCRTTCCNCCS;CSPCCQPTCCGSSCCEPCCC;CTPVYCRRTCYQPTCCC;ESCCSPCCQPTCC;ESCCSPCCQPTCCGSSCCEPCCCL;GCGSNCCQPCCQPTCC;GCLAQGCGSNCCQPCCQPTCCQNNC;GSNCCQPCCQPTCC;MSESCCSPCCQPTCCGSSCCE;NCCQPCCQPTCCQ;PCCQPTCCGSSCCEPCC;PGCLAQGCGSNCCQPCCQPTCCQ;PTCCGSSCCEPCCCLPTCCHTT;QGCGSNCC;QPTCCGSSCCEPCCC;RPTCCHTTCCRTTCCNCCSTPCS;RRTCYQPTCCC;SCCEPCCC;SCCEPCCCL;SCCSPCCQPTCCGSSCC;SESCCSPCCQPTCCGSSCCEPCC;SPCCQPTCCGSSCCE;SPCCQPTCCGSSCCEPCC;SSCCEPCCCLPTCCHT;TCCGSSCC;TCCGSSCCEPCC;TCCGSSCCEPCCC;TCCGSSCCEPCCCLPT;TTCCNCCS;TTCCRTTCCNCCST 44 96.8 0.99755 -3.3954 4.6084 5.99883 7.18903 6.55064 6.73971 8.86059 7.1267 9.7657 12.7121 5.91198 0 9.57211 7.70287 8.2493 10.2842 A0A8C0SEC0 A0A8C0SEC0_CANLF "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3)" MAGI3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTESQRKRT;GAERGEFPYL;IPDHGLAPSGL;LPYGWEKIEDPQ;MVYFIDHNTK;VLEQNGKPGHALISDRLNGPSDPSE;YGWEKIED 7 6.9 0.99956 -2.8982 10.2688 10.9882 10.1929 0 0 12.9403 10.4832 0 10.3839 8.7075 10.5019 10.2997 10.9474 11.5015 9.42991 A0A8C0SEC4 A0A8C0SEC4_CANLF TNF receptor superfamily member 9 TNFRSF9 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285] external side of plasma membrane [GO:0009897] signaling receptor activity [GO:0038023] EDACSCRFPEEE;SNAECECIS;VATVLLLMN;VLFLVFFLILRFSVIKHGRKKLL 4 20.8 1.003 -0.85792 0 0 0 0 0 8.13632 0 3.88577 0 0 0 0 0 0 10.6475 A0A8C0SED1 A0A8C0SED1_CANLF Retroviral envelope protein GP41-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] structural molecule activity [GO:0005198] DDMEVANHSISWTGLAAQ;LDGLHGFNPG;VELQLQLKRLKRFL;VISPHGIPEFSITDWSRMTR 4 9.6 1.0041 -0.82163 0 0 0 0 0 10.6628 10.6893 0 0 0 0 0 0 0 0 A0A8C0SED2 A0A8C0SED2_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" B4GALT6 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] EIHQLFSKDLDIEP;LDKYMYILPYKEFFGGV;VIEQTGTQPFNRAMLFNVGF 3 14.9 0.9852 -0.44029 0 10.3895 0 0 0 0 0 0 8.58218 0 0 0 0 0 0 A0A8C0SEE9 A0A8C0SEE9_CANLF mitogen-activated protein kinase kinase (EC 2.7.12.2) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] DLDSKACISIGNQ 1 4.2 0.9393 0.059794 0 0 0 0 0 0 0 0 10.1874 0 0 0 0 0 0 A0A8C0SEG9 A0A8C0SEG9_CANLF DNA-directed RNA polymerase I subunit RPA12 (DNA-directed RNA polymerase I subunit H) Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AGAAGLRGAAGGPGVPA;EGMAYHTRQMRSADEGQTVFY 2 17.8 0.98824 -0.47262 8.11962 7.74187 0 0 0 0 0 0 0 0 0 0 0 0 9.05637 A0A8C0SEH8 A0A8C0SEH8_CANLF Link domain-containing protein LYVE1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] hyaluronic acid binding [GO:0005540] LCDFFAEL;PGLCSIIYKLE;SISGPCRIVGV 3 8.5 1.0034 -1.0334 7.06566 0 0 0 0 0 7.32787 0 9.69279 0 0 0 0 10.3875 0 A0A8C0SEI5 A0A8C0SEI5_CANLF SAM domain-containing protein SAMD13 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] RAAPALGA;SQGRVRPSEGGISLNTPNLQ 2 11.7 0.98397 -0.24251 0 0 8.39008 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SEJ4 A0A8C0SEJ4_CANLF RNA helicase (EC 3.6.4.13) DDX3X Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gamete generation [GO:0007276] nucleus [GO:0005634]; P granule [GO:0043186] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GVRHTMMFSATFPKEIQ;ISLVLAPTR 2 4.3 0.98942 -0.21588 0 0 0 0 0 0 8.60604 0 8.98237 0 0 0 0 0 0 A0A8C0SEK2 A0A8C0SEK2_CANLF Parkinsonism associated deglycase PARK7 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; inflammatory response [GO:0006954] membrane [GO:0016020] KDPVQCSRDVIICPDASLED 1 11.8 0.96414 0.048688 0 0 0 0 6.3233 0 0 0 0 0 0 0 0 0 0 A0A8C0SEK6 A0A8C0SEK6_CANLF Prothrombin (EC 3.4.21.5) (Coagulation factor II) F2 Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] AEDQDTAIEGR;CDLDYCEEPVE;DGLAEDQDTAIEG;DKTEGELLESYIDG;EEGAWCYVSEE;GGVTVPLTPR;GLAEDQDTAIEG;GVTVPLTPR;IQKVIEKSGG;IVEGWDAEIGL;KTEGELLESYIDG;LAEDQDTAIEG;QGGVTVPLTPR;QGHLAMSQLRL;QKVIEKSGG;QQGGVTVPLTPR;SGGPTVNLSPPSE;SVKDKTEGEL;SVKDKTEGELLESYIDG;TEGELLESYIDG;TSSIGEVQPR;TTAEEFQPFF;TTAEEFQPFFNE;TTAEEFQPFFNEK;TTAEEFQPFFNEKTF;TTAEEFQPFFNEKTFG;TTAEEFQPFFNEKTFGA;TTAEEFQPFFNEKTFGAG;VGDGLAEDQDTAIEG;VTVPLTPR 30 22 0 18.5 13.8238 14.0761 14.1248 13.3856 13.2348 12.9789 14.1433 14.2747 13.5755 13.2077 13.5101 13.2121 14.2849 14.1994 14.1166 A0A8C0SEM1 A0A8C0SEM1_CANLF "Zinc finger CCCH-type containing, antiviral 1" Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950] FVIYEKDQI;KVHFHLPYRW;VLVGDFTQGYRESLN 3 3.9 0.99484 -0.18923 0 0 0 0 0 0 0 6.00935 0 0 0 0 9.3411 0 0 A0A8C0SEM6 A0A8C0SEM6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PIHPSIHPSIDPSIHP;PSIHRSIYPPIH 2 10 0.99334 -0.17606 0 0 0 8.67349 0 0 0 10.8153 0 0 0 0 0 0 0 A0A8C0SEQ6 A0A8C0SEQ6_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AGITLLSSL;ESICNPLLYSVVMS;GVTIFYGSLIFTYLQPD 3 12.9 1.0014 -0.69687 8.45372 0 0 0 0 8.85891 0 0 8.87649 0 0 0 6.88496 0 0 A0A8C0SER1 A0A8C0SER1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] ribonuclease P complex [GO:0030677] AEESTMMSYFSNY;ERISWSFKEKKPLKF;RWARGPCPLLS;VSPVLQSGR 4 9.8 0.98493 -0.4455 0 0 0 0 0 0 0 9.52366 0 0 0 8.78758 11.0276 0 0 A0A8C0SEU2 A0A8C0SEU2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCVSSCCQPSCCGSSGCGSSCCQP;CCEPSCCGSSCCE;CCEPSCCGSSCCEPCCCR;CCEPSCCGSSCCEPCCCRPTCC;CCGSSCCEPCCC;CCGSSGCGSSCCQPCCC;CCHPSCCCTPCSQPACCTP;CCQPCCHPSCCC;CCRTTCCEPSCCGSSCCEPCCC;CCRTTCCEPSCCGSSCCEPCCCR;CCVSSCCQPCCHPSCCCTPCSQP;CCVSSCCQPCCHPSCCCTPCSQPA;CCVSSCCQPSCCGSSG;CEPSCCGSSCCE;CEPSCCGSSCCEPCC;CEPSCCGSSCCEPCCCRPTCCHT;CQPCCHPSCCC;CQPSCCGSSGCGSSCCQPCCCRP;CRTTCCEPSCCGSSCCEPCCCR;CVSSCCQPCCCRPTCCQT;CVSSCCQPSCCGSSGCGSSC;CVSSCCQPSCCGSSGCGSSCCQPCC;EPSCCGSSCCEPCCC;EPSCCGSSCCEPCCCR;ESCCSPCCQPTCC;GCGSSCCQPCCCRPTC;GCGSSCCQPCCCRPTCCQTT;KPACCVSSCCQPCCCRPTCCQT;PSCCGSSCCEPCCCRPTCCHTTCCR;PSCCGSSGCGSSCCQPCC;PSCCGSSGCGSSCCQPCCCRP;RRTCYQPTCCC;SCCCTPCSQPACCTPVI;SCCEPCCC;SCCGSSCCEPC;SCCGSSCCEPCCC;SCCGSSCCEPCCCRPTCC;SCCGSSGCGSSCCQ;SCCGSSGCGSSCCQPCCCRP;SCCQPCCHPSCCC;SCCQPCCHPSCCCTPC;SCCQPCCHPSCCCTPCSQPACCT;SCCQPSCCGSSGCGSSCCQPCCCR;SSCCQPCCHPSCCCTP;SSCCQPSCCGSSGCGSSCCQPC;SSCCQPSCCGSSGCGSSCCQPCC;SSGCGSSC;SVSSCCQPSCCGSSGCG;TCCEPSCCGSSCCEPC;TCCEPSCCGSSCCEPCCC;TCCRTTCCEPSCCGSSCCEPCCCR;TTCCEPSCCGSSCCE;TTCCEPSCCGSSCCEP;TTCCEPSCCGSSCCEPCC;TTCCEPSCCGSSCCEPCCCRP;TTCCKPACCVSSC;TTCCKPTCCVSSCCQPCCHPSCCCT;VSSCCQPCCHPSCCCTPCS;VSSCCQPSCCGSSGCGSSCCQPCCC 59 85.8 1.0028 -0.77751 8.0662 8.27352 9.00899 9.4354 8.48696 9.90382 10.1973 12.2668 9.72153 9.60145 6.83832 7.48164 9.53292 10.0454 9.06768 A0A8C0SEY3 A0A8C0SEY3_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018] metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AEGFHEKDKKPYCRKDF;EDALLEELERSTLQD;PECFVCGDCFSSFSSGSFF;TSETVSVQNDPSPLPVQLV 4 18.2 0.93684 0.066313 0 0 0 0 0 0 0 0 0 0 0 0 10.2881 0 0 A0A8C0SEY4 A0A8C0SEY4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DLTELECRIVDM;DVRLDTVG;NIFWASEDSVL;NPIEIDFQTAGPI;TLKYGDRSKQR 5 6.5 1.0022 -1.443 9.36977 0 0 0 0 0 14.5903 15.3804 0 0 0 8.94084 0 9.73983 11.2078 A0A8C0SEY7 A0A8C0SEY7_CANLF NAD-capped RNA hydrolase NUDT12 (EC 3.6.1.22) (NADH pyrophosphatase NUDT12) (Nucleoside diphosphate-linked moiety X motif 12) NUDT12 Canis lupus familiaris (Dog) (Canis familiaris) NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742] cytosol [GO:0005829]; peroxisome [GO:0005777] metal ion binding [GO:0046872]; NADH pyrophosphatase activity [GO:0035529] ETIEDAVRRE;LVAWFALGIDSVAAEEFKQRHEN;VLAWHSRYKF 3 10.2 1.0031 -1.1178 0 0 0 0 0 13.0319 0 0 0 12.2551 0 0 0 0 12.7883 A0A8C0SEZ3 A0A8C0SEZ3_CANLF Zinc finger FYVE domain-containing protein 26 ZFYVE26 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; mitotic cytokinesis [GO:0000281] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266] EIQALYMGSKVL;LDPTGAWHA;LEQFPMLKASLLAAWEPL;LVRSEFYY;MERYQEVIQ;MTAADVSRHMNTLQLQMEVTRFLH;NCCIEDPSTVMNMILEAKE;QGFPFVLQQ;SSHATLSQQLDQVLQS;SSLLTHLGILV;VPEENPGQP;YISKVDVLNILVAA 12 6.3 0.99698 -3.5979 0 0 10.016 0 8.66743 0 0 0 9.76437 0 0 14.3701 16.5559 16.4775 16.4082 A0A8C0SF02 A0A8C0SF02_CANLF Rho guanine nucleotide exchange factor 40 ARHGEF40 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] EALALEEDAASQKVLDVFEQRLEQ;EQGQLLHRDPFTVICGRKK;GAELLSESDL;GAPVSAHC;LEGPGPAAVYQ;PLETAQEVGGASVPEEASPVSI;VLSTALRYLHSL 7 6.9 0.99011 -0.26592 0 0 0 0 0 10.0077 0 0 0 0 0 0 0 0 0 A0A8C0SF11 A0A8C0SF11_CANLF 60S ribosomal protein L32-like LOC479087 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LVKPKVIKKRTKKFIRHQSDRYVKI;TKKFIRHQSDRYVKIKRTWQ 2 22.2 0.97597 0.035538 0 0 0 0 0 0 0 0 5.85634 0 0 0 0 0 0 A0A8C0SF12 A0A8C0SF12_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGDCNTDSDGYSK;DEESLADLSSLSILRLSHNSISH;FTGLDSLSKLNLGEN;SLVWVCIIYQTRKKS 4 6.5 0.99374 -0.12709 0 0 0 0 0 0 0 10.4927 0 0 0 0 0 0 0 A0A8C0SF13 A0A8C0SF13_CANLF AP-3 complex subunit delta domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-3 adaptor complex [GO:0030123] DLSVPLKVPGMPMSDQYVKLEE;GVGSSLRIFWLDVNTTQ;HRQRLERDKKRKKKKDKDKKGKPR;IAVLISLSSGMP;KKDKKHREKER;KKPKKKDKKHREKEREK;KKVKKPKKKDKKHR;LGKKLIEP;NWVLIKIIKLFG;PESLRPAFPR;PPSDSESE;QKLKGTLSFIAKND;RQRLERDKKRKKKKDKDKK;RTHPKSVQAHKDLVLQCLDDKDES 14 13.5 1.0041 -1.994 9.96035 5.36702 8.43438 0 0 6.83453 9.43329 8.92029 0 4.27075 0 0 6.40873 0 0 A0A8C0SF15 A0A8C0SF15_CANLF UTP20 small subunit processome component UTP20 Canis lupus familiaris (Dog) (Canis familiaris) AEKELQNDVRDEKSIGDESWE;AGDDEELEEEAVP;AKKKLKKHKNKS;EPSQKKKT;EVMEANLPSIL;HVLQTGQINQKLG;HVLTFTVYMLLQ;IRKQKTKKTKKK;ITYLSQSWAALV;KHPHILPYRENLQ;LDCIMTYKH;LFDTFPQGLLHEN;NTIEVIELP;SLLITLLLPFLQRGNIAQD;VGSYLRQKKT;YKEVIDKCQSFNQLVYHQNEI 16 7.7 0.99746 -3.493 0 10.9477 0 7.96895 0 11.1005 11.0293 10.5754 11.3869 0 13.0041 10.0625 8.94597 7.736 10.6947 A0A8C0SF35 A0A8C0SF35_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MDAFLESHKL;MNEKGEITTNT;SVGIEGAFLDI 3 5 0.98909 0.035491 0 0 0 0 0 0 0 10.1812 0 0 0 0 0 0 0 A0A8C0SF49 A0A8C0SF49_CANLF Desmoglein 3 DSG3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AAIGLLLLGLLLLLLAPLLLLT;EFLKSYFTEKAA;GSAAIGLLLLGLLLLLLAPLLLL;GSAAIGLLLLGLLLLLLAPLLLLT;IVDREETPSFQ;IVSQEPAGTPMFLLSRHTG;KDVNDNFPMFKESQYSAH;PKTAQIKFV;SAAIGLLLLGLLLLLLAPLLL;SAAIGLLLLGLLLLLLAPLLLL 10 8.2 0.92108 0.11514 0 11.9281 6.15963 10.4044 6.61874 9.70084 0 10.909 7.83276 0 3.21847 7.47176 5.18106 12.5532 2.72923 A0A8C0SF55 A0A8C0SF55_CANLF Pleckstrin homology and RUN domain containing M1 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] endosome [GO:0005768]; lysosome [GO:0005764] metal ion binding [GO:0046872] DLCTQRGFICQICHHHDIIFPF;ESPHKYSVADLQQIA;ETIRDILP;IPFDVPAEPLLAQAS;VIKKKLVGSVKALQK 5 7.3 0.94918 0.053909 0 0 0 0 0 0 0 0 0 0 0 0 6.96197 0 0 A0A8C0SF69 A0A8C0SF69_CANLF "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Malate dehydrogenase [quinone] cytochrome b560 subunit)" Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739]; succinate dehydrogenase complex [GO:0045281] electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] ALVFPLMYHTW;HFKVFWFY;KGLKIPQLYQSGVAVLVLTVL 3 21.2 0.99585 -0.092264 11.7866 0 11.8473 0 0 0 0 11.6992 12.0248 0 0 0 0 7.64212 0 A0A8C0SF77 A0A8C0SF77_CANLF phenylalanine--tRNA ligase (EC 6.1.1.20) FARS2 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412]; tRNA aminoacylation [GO:0043039] aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] KASSVSKG;THKTSHCYRITYRHMERTLSQREV 2 7.8 0.97421 0.041303 11.0743 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SF82 A0A8C0SF82_CANLF Glutamine amidotransferase-like class 1 domain-containing protein 1 (Ferry endosomal RAB5 effector complex subunit 5) (Parkinson disease 7 domain-containing protein 1) Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769]; extracellular region [GO:0005576] AWPHTPAPHSHLP;GGAAHAPE;RLSLVVEDFVKD;SEPDAVHVVLDRHL 4 9.2 1.0035 -1.6009 9.53241 0 0 0 0 0 0 0 0 0 9.27018 5.33239 0 0 0 A0A8C0SF92 A0A8C0SF92_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SIK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APGLEEEREAQKP;ATGLPQGDCEMEDLTAGQLGTF;DLTAGQLGTFVLVQ;ETKDMLYIVTEFAKNGEMFDYLT;TASLDGVANWL;TKDMLYIVTE;YDEQVLGIMHTLGI 7 10.4 1.0018 -1.2106 0 0 8.84912 0 0 10.7532 0 0 0 0 7.85705 9.2659 9.37234 9.07948 0 A0A8C0SF93 A0A8C0SF93_CANLF Chromo domain-containing protein CDYL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription corepressor activity [GO:0003714] DSEDDTWEPEQHLVNCEEYIHDF;GVTAGKRK;STLTRTNRTSPNNARK;TAGKRKFIDDRRDQPFDKR;WEPEQHLVNCEEYI 5 12.1 1.0022 -1.2333 2.89542 0 10.5399 8.50898 0 0 0 0 0 0 0 0 5.57098 0 0 A0A8C0SFA7 A0A8C0SFA7_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ILEECNKEFCVVCPDYMS;LVYNTPSSDSRR;VLPRILVKI 3 8.1 1.0011 -0.70546 10.3461 0 0 0 0 0 0 0 7.08247 0 6.98242 0 0 0 0 A0A8C0SFB4 A0A8C0SFB4_CANLF SOCS box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] AKKLLESG;EAAKRGHVGCLETLAAH;IVSDWSPVHEAAI;KKLLESGASVNQGRG 4 15.7 1.003 -1.009 0 0 0 0 8.4099 0 0 0 0 8.98319 0 0 0 0 0 A0A8C0SFB7 A0A8C0SFB7_CANLF Adenosine deaminase domain containing 1 ADAD1 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] IVVVCYMMVEVNIY;LVPSAYPLQTNLEY 2 4.7 0.99154 -0.18127 0 0 0 0 0 12.934 0 0 0 11.6858 0 0 0 0 0 A0A8C0SFD3 A0A8C0SFD3_CANLF RRM domain-containing protein LOC100855475 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] PSRYERTVDTMTPSAQIIQKSFSS 1 9.2 0.99192 -0.29131 0 0 0 0 0 0 0 0 0 0 0 0 0 9.89727 0 A0A8C0SFE2 A0A8C0SFE2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] membrane [GO:0016020]; ribonuclease P complex [GO:0030677] AEESTMMSYFSNY;ERISWSFKEKKPLKF;ILPEKICLLLEQLWL 3 11 0.94821 0.05391 0 0 0 0 0 0 0 0 0 0 0 0 0 4.45759 0 A0A8C0SFE3 A0A8C0SFE3_CANLF SCP domain-containing protein GLIPR1L1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] DAWFNETEYYDY;YDYDTLSCTKVCGHYT 2 10.7 0.93318 0.099673 3.35233 0 0 5.74424 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SFG1 A0A8C0SFG1_CANLF Programmed cell death 6 interacting protein PDCD6IP Canis lupus familiaris (Dog) (Canis familiaris) multivesicular body sorting pathway [GO:0071985] DTLPKYFYFQEV;FPFSENQICLTFTWK;LSKLRRAA;VGTGTAPP 4 4.9 1.0034 -2.3938 0 0 9.75226 0 0 7.89597 0 12.018 0 10.0909 10.2181 0 9.72658 0 4.34632 A0A8C0SFG7 A0A8C0SFG7_CANLF Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (KLRAQ motif-containing protein 1) STON1 Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769] RNA binding [GO:0003723] EARRWWPS;ETSARAALE;GVVDEQANSAALKEQL;KFSQYLHENASYVRPLEEGMLHLFE;LLQDELALSEPRGK;TCCGAGAG;VALTNGAGKPLLESVPYEE 7 11.8 1.0036 -2.0304 7.39712 9.9935 8.24189 9.35652 0 0 0 6.33987 6.66178 0 0 0 0 0 0 A0A8C0SFH3 A0A8C0SFH3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APGLEEEREAQKP;ATGLPQGDCEMEDLTAGQLGTF;DLTAGQLGTFVLVQ;ETKDMLYIVTEFAKNGEMFDYLT;RRAGVVPG;TKDMLYIVTE;YDEQVLGIMHTLGI 7 8.3 0.99012 -0.26592 0 0 0 11.6242 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SFH4 A0A8C0SFH4_CANLF Dedicator of cytokinesis 11 DOCK11 Canis lupus familiaris (Dog) (Canis familiaris) marginal zone B cell differentiation [GO:0002315]; positive regulation of filopodium assembly [GO:0051491]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EDAGMMDVH;EIEEFFPE;ELKKLCSS;HLSSLESSFTLNH;INNFANSDRPMKAA;IQDSDKVNAKELDPKYAHI;KEDAGMMDVH;PELMKYGRETEQLN;QEDTIHSPWM;YIVKMISEDTLLTY 10 5.5 0.98946 -0.21676 0 0 0 0 0 0 0 0 0 0 0 0 0 9.65589 0 A0A8C0SFI1 A0A8C0SFI1_CANLF Myosin VB MYO5B Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050] cytoplasm [GO:0005737]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AAIIIQCAFRMLKAKQELKALKI;DALQQVEVEQAKNDLDVDQDAD;DESIREYPIDVQSNQ;FGKYIQIGFDKRYH;HATEVEKLKKELA;KDEKEQLNN;VEKLEKNERKLKKQLKIYMKKVQDL;YHQSQGGG 8 7.3 1.0013 -0.94023 7.61449 7.44112 0 0 7.26238 7.68278 5.23209 11.2658 9.14229 0 0 7.91845 0 6.17838 10.492 A0A8C0SFI2 A0A8C0SFI2_CANLF HEXIM P-TEFb complex subunit 1 HEXIM1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; snRNA binding [GO:0017069] QEEPDLKTGLYP;RHWKPYYKLTWEEKKKF;RWQSRASPQSGGRP 3 12 0.99499 -0.15236 9.59789 0 0 0 0 0 0 0 0 0 0 8.22391 6.71987 0 0 A0A8C0SFI6 A0A8C0SFI6_CANLF Zinc finger protein 500 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ETFRQLFRL;PAEPPHSAAPGGPWAK;RTHTGERPYACAE 3 8.2 0.99293 -0.16052 0 0 0 0 0 0 0 10.5124 0 8.78401 0 0 0 2.7681 8.27398 A0A8C0SFJ6 A0A8C0SFJ6_CANLF FIG4 phosphoinositide 5-phosphatase FIG4 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] membrane [GO:0016020] "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]" AANLKKLI;DKPNLQFDTDAVRLFE;VISSNPIT 3 3.6 1.0022 -0.65102 0 0 8.29499 0 0 0 0 8.66299 0 0 3.19088 0 0 8.71043 0 A0A8C0SFK9 A0A8C0SFK9_CANLF Dihydrolipoyl dehydrogenase (EC 1.8.1.4) DLD Canis lupus familiaris (Dog) (Canis familiaris) acrosomal vesicle [GO:0001669]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; oxoglutarate dehydrogenase complex [GO:0045252] dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660] LRTYADQP;TPFPGITIDEDTIVSSTG 2 5.6 0.94341 0.08761 0 0 0 0 0 0 9.32519 0 0 0 0 0 13.7932 0 0 A0A8C0SFL7 A0A8C0SFL7_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] AEGPHSPSCQQPPSPP;APSPAPTPSPTPVEDLGLQ;EEDEEEDEEEEEVAV;GGKGSTPYRAGDGGI;GVGRRNSLES;HNGPHTPWAPRAEEEDEEDEEEDEE;LDLDGEAPDDEEPE;MVPPGTTGGKMAEGP;PMASPEQLSFRER;SIAGGKGS;SLDLDGEAPDDEEPE 11 9.2 0.98746 -0.36966 8.63941 0 10.0829 0 10.5208 5.51592 7.04985 0 6.13264 0 0 9.37447 0 11.0548 0 A0A8C0SFL9 A0A8C0SFL9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CDLTSRSQPSSV;DPSPQTQVVKS;EESENSLSFESQHSLKPSYL;ERRCRSPSERSHRSTSQKSHHI;ESEALITKSLHHVPESPEMTS;ESKLPCVNSTGCKLGPPLQ;ETHVESRKVTMEPHL;IQNLFGVPAELMKP;ISSSTSSVFV;ITGAKRHV;KGVKSELNP;KSVPLTPGPR;KTDFSEQFQLLQDL;LQDIQSVGFE;LTSEPKHQ;PSQKSHHSASERRHH;PVALGSPMGMIIASQS;QDTKSVELAPG;QDVRFSDL;QSQIVETPDLTSRP;SAPELQLQVVNSD;SLQSSPRAQLQGV;SMVFNPDR;TEFNFGPQLQNV;TPQPYHQRTETMAL;TSASLRRQ;VGGRNLHGSPHRTS;VGHTESVELT;VGLTSRQWLQRRQ;VGPQFKVAESV;VLIRRAITVPLRGAIAVLLRRAITV;VRPSEFTSELWLQ;WAQEYILWSMNRSLQ 33 7.5 0.97516 0.035538 0 0 0 6.24407 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SFP7 A0A8C0SFP7_CANLF Monocarboxylate transporter 1 (Solute carrier family 16 member 1) Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] monocarboxylic acid transmembrane transporter activity [GO:0008028] AEKQQKKESREEKPREVIKTAESI;LSTLAPLNQAFF;QELYLCIGV 3 9.4 1.0032 -1.0262 0 0 7.14098 0 0 0 0 0 0 9.01689 0 0 6.62628 0 0 A0A8C0SFP8 A0A8C0SFP8_CANLF CDC42 small effector protein 1 CDC42SE1 Canis lupus familiaris (Dog) (Canis familiaris) phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] KPQPKKKRRRI 1 13.9 0.9784 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 8.29687 0 0 A0A8C0SFQ3 A0A8C0SFQ3_CANLF Family with sequence similarity 221 member B Canis lupus familiaris (Dog) (Canis familiaris) HYIWDCFRIGDESKCFCG;KKKGKKGV;LETHTSETPL;RWEEHETFFETEETRRRGGRPHG;TSESHMAPSTSQ 5 16.1 1.003 -1.5308 0 12.0127 0 8.79107 0 0 0 3.5656 0 0 0 6.03089 0 10.3677 0 A0A8C0SFX5 A0A8C0SFX5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APGLEEEREAQKP;ETKDMLYIVTEFAKNGEMFDYLT;LSPARHQSPPAL;SPARHQSPPAL;TKDMLYIVTE;YDEQVLGIMHTLGI 6 8.4 0.99116 0.00012083 11.939 0 14.5367 12.2442 12.1605 12.2479 12.3839 0 0 14.5775 0 0 0 0 0 A0A8C0SFY2 A0A8C0SFY2_CANLF EF-hand domain-containing protein EFCAB3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] WSWNVCQELLSP;YHNFVFSSSSDI 2 5.5 0.94069 0.10088 0 7.71136 0 0 0 0 0 0 0 0 0 8.87064 0 0 0 A0A8C0SFZ4 A0A8C0SFZ4_CANLF Dedicator of cytokinesis 11 DOCK11 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EDAGMMDVH;EIEEFFPE;EKDPEMLIDLQYSLAKSY;ELKKLCSS;FANSDRPMKAT;HLSSLESSFTLNH;IQDSDKVNAKELDPKYAHI;KEDAGMMDVH;PELMKYGRETEQLN;QEDTIHSPWM;YIVKMISEDTLLTY 11 6.1 0.99723 -3.9921 0 0 5.9865 8.21854 9.80266 6.75449 0 0 6.84587 0 0 0 0 9.01992 11.2937 A0A8C0SG05 A0A8C0SG05_CANLF Zinc finger protein 235 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DPGYSSAIPVQQSVYTGKKRYWCHE 1 3.5 0.97693 0.035538 0 7.00371 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SG39 A0A8C0SG39_CANLF Propionate--CoA ligase (EC 6.2.1.1) (EC 6.2.1.17) Canis lupus familiaris (Dog) (Canis familiaris) acid-thiol ligase activity [GO:0016878]; ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405] FWGPLARDALVWDAPYHT;VVKRLPKTRSGKVMRRLLRKIIT 2 5 0.92935 0.094566 0 0 0 0 0 0 0 6.61001 0 0 6.01732 0 0 0 0 A0A8C0SG45 A0A8C0SG45_CANLF Ig-like domain-containing protein FCGR2B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] HLDVTSDWLLLQTPRL 1 5.6 0.96369 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.66896 A0A8C0SG51 A0A8C0SG51_CANLF VWFD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEGCQCDP;CDDGCQNDCPSCT;CDSPCAEGCQCDSGF;CFEGCECDD;DLCDDGCQNDCP;DNQRSRLPASLAEG;FLTADLELA;GDDLCDDGCQNDC;HYEACSRGCPMSCGDLPVPGGC;LDDGDDLCDDGCQN;LDDGDDLCDDGCQNDCPS;LSSDCHQRCS;PTCKPGEDCNSSP;PVNSSLLSSDCH;QETAPYESNQACGQIRDPN;QTCREGCVCDAGFVL;SAPEGCVQTCREGC;SDDFVLPNGAEASSVDA;TVTYNWNDRVIAK 19 7.8 0.9969 -4.1526 8.47768 4.60318 10.301 11.5596 9.69867 9.17951 0 4.31419 10.9889 9.14886 0 8.03364 9.77018 9.9678 8.60184 A0A8C0SG53 A0A8C0SG53_CANLF Outer dense fiber of sperm tails 4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PTRWDSNSHPKSE 1 4.9 0.99131 -0.27003 0 0 0 8.98345 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SG56 A0A8C0SG56_CANLF Sharpin PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PQDRRAAARPPFGPHCIR;SPRKRGRTGDGMAPPSGPG;VSAGGGGA 3 8.3 0.98991 -0.26592 0 0 0 0 0 0 0 11.7071 0 0 0 0 0 0 0 A0A8C0SGA7 A0A8C0SGA7_CANLF PKHD1 like 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGVEVFMGHFPCKVLSVNYT;AYGHILKGLPATV;ESEIKCQI;GLKLEIWNNSRPVHLEEILE;IPQWQSYQ;LEVTAMFP;LRRKRSMGLTVELEIGDPPPQF;LSWNTSKN;SPFQHRAVITL;TILTILGSG;TPWSSEAEFQ;TVLNLNINP;VGSSPGFNCSDVLTN;VGTAAQIMII;VLNATYISLQGGRLIGGWEDN 15 4.5 0.97447 0.046925 0 0 0 8.08683 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SGA9 A0A8C0SGA9_CANLF BTB domain-containing protein KCTD21 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin family protein binding [GO:0097602]; histone deacetylase binding [GO:0042826] FLKLLGSK;ILNFLRTSHLDL;TLNQRVQTVHF 3 11.9 0.99149 -0.54774 0 8.65957 0 0 0 0 0 8.7985 0 0 9.18267 9.12052 0 0 8.94348 A0A8C0SGB4 A0A8C0SGB4_CANLF UDENN domain-containing protein DENND2D Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AAGGGGGG;CIGCFGLFSKIL;EGAGLRGLSELR;GAAPSRTRVS;GGGGGGGA;GVQMRFQQ;TFSFVLTNVDG 7 9.9 1.0035 -2.2803 0 0 0 0 0 0 9.38513 0 0 8.20286 0 0 0 0 8.1114 A0A8C0SGB9 A0A8C0SGB9_CANLF UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Canis lupus familiaris (Dog) (Canis familiaris) uridylyltransferase activity [GO:0070569] PDGNGGLYCALSDHQILDDMER;VIMFEQRMLPAVNFDG 2 7.5 0.9732 0.046699 0 0 0 10.664 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SGE0 A0A8C0SGE0_CANLF LysM domain containing 1 LYSMD1 Canis lupus familiaris (Dog) (Canis familiaris) NRLYTNDSIFLKKTLY 1 8.9 0.96433 0.049233 0 0 0 7.49089 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SGE8 A0A8C0SGE8_CANLF Complex 1 LYR protein domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] L-cysteine desulfurase complex [GO:1990221]; mitochondrion [GO:0005739] RPRHPQAPP 1 2.1 0.99035 -0.26823 0 0 0 0 0 0 0 11.1737 0 0 0 0 0 0 0 A0A8C0SGE9 A0A8C0SGE9_CANLF IZUMO family member 4 Canis lupus familiaris (Dog) (Canis familiaris) ADQHSAHRR;AVVRCGAGPAPGAGAGGRRWLAGGG;GACGAGPA 3 7.3 1.004 -1.1024 0 0 0 0 0 0 0 9.89562 0 0 0 0 9.97585 0 0 A0A8C0SGF2 A0A8C0SGF2_CANLF BRMS1 transcriptional repressor and anoikis regulator Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826] EAEGDSAAEMNGEEEESEEER;LVSGPYIVYML 2 13.1 0.98425 -0.23918 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.97911 A0A8C0SGL3 A0A8C0SGL3_CANLF Pleiotropic regulator 1 PLRG1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" QEVEYLVTG;TNAVATVRCQAAEPQI;VLHPRHYTF 3 7.2 1.003 -0.72233 0 0 0 9.40535 0 0 0 10.6547 0 0 0 0 0 0 0 A0A8C0SGL4 A0A8C0SGL4_CANLF SAM domain-containing protein ANKS3 Canis lupus familiaris (Dog) (Canis familiaris) PQTERSPYSGP;PTPEGQTPLML;RLEAEMQELAIQLHKRCEEV 3 7.2 0.98825 -0.47404 0 0 6.01859 0 8.1534 9.20117 0 0 0 0 0 0 6.95571 0 0 A0A8C0SGL5 A0A8C0SGL5_CANLF Uncharacterized protein NMT1 Canis lupus familiaris (Dog) (Canis familiaris) AKKKKKKQKKK;AKKKKKKQKKKK;GAKKKKKKQKKKKEK;PANDTGAKKKKKKQKKKK;QEIQSHPSIP;TGAKKKKKKQKKKK 6 22.7 0.98758 -0.36257 4.80002 0 4.66596 4.93636 0 8.16682 0 9.44023 0 9.89458 9.08717 0 0 0 0 A0A8C0SGL7 A0A8C0SGL7_CANLF R3H domain containing 2 R3HDM2 Canis lupus familiaris (Dog) (Canis familiaris) GSEQYQMPQSPSPCSPP;SIGSSKGG;SSKGGSAG;YTIVAVFP 4 5.4 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 14.997 0 0 A0A8C0SGM8 A0A8C0SGM8_CANLF mRNA decay activator protein ZFP36 (Zinc finger protein 36) ZFP36L1 Canis lupus familiaris (Dog) (Canis familiaris) "3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; mesendoderm development [GO:0048382]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; regulation of B cell differentiation [GO:0045577]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; regulation of translation [GO:0006417]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]" nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904] 14-3-3 protein binding [GO:0071889]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925] GFPSAAATAAATGLLDSP;PRRHSVTLPSSKF;PSAGGCLL;PSPQDSLSDQE 4 14.8 1.0032 -1.5419 0 0 0 11.1171 0 0 0 11.6953 0 0 0 0 0 0 0 A0A8C0SGN3 A0A8C0SGN3_CANLF Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase) ACSL1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467] AITYIINKAELSLI;EPLVYFYDDVRTI;QFSLGNHQH;RSGIIRNNSLWDKLIFHKIQ 4 7.5 1.0031 -1.3368 0 0 5.2669 0 0 0 10.0414 0 9.23819 0 0 0 0 0 0 A0A8C0SGU0 A0A8C0SGU0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PDGFRGEFYQTFK 4 5.3 0.94157 0.059729 0 0 0 0 0 0 7.87719 0 0 0 0 0 0 0 0 A0A8C0SGU3 A0A8C0SGU3_CANLF Olfactory receptor OR5D15 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] INNFVCEHSVI 1 3.6 0.9885 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.98162 A0A8C0SGY4 A0A8C0SGY4_CANLF Transmembrane protein 151A TMEM151A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AVPSGPPL;FRESLMVFADPRSP;GAVPSGPPL;YHYVRRTRQITRYRNGDAYTTTQV 4 10 1.0026 -0.77107 0 0 0 0 0 0 0 9.39333 0 0 0 0 8.33101 0 0 A0A8C0SGZ5 A0A8C0SGZ5_CANLF RRP15-like protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] AGSYLEGGRCTCLWLPQGGA;DTCLWLPQRGA;GGGGGGGG;RPGPGQGP;VGAGKKLKNSLKKKQRKK 5 8.2 0.98769 -0.46579 8.58901 0 0 0 0 0 0 8.94483 0 0 0 8.74937 0 0 0 A0A8C0SH06 A0A8C0SH06_CANLF Chorein N-terminal domain-containing protein BLTP3A Canis lupus familiaris (Dog) (Canis familiaris) AIHMTKDAT;DIPPIYPTSP;GPIPITLAMEHIVLKR;IEGELSSAIHMTKD;KPPWHLGV;LFTSVLNGLGPFLED;LVSPSGEGLS 7 5.4 0.99889 -3.2656 0 9.65023 0 0 0 0 0 0 0 8.52536 9.87997 0 8.63201 0 0 A0A8C0SH17 A0A8C0SH17_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] NKIMNVKG;PSICCLQETHFRQ;VGITMPDFRLYYKA 3 3.6 0.98922 -0.19965 3.44414 0 0 0 0 0 0 7.27566 0 0 0 0 0 0 0 A0A8C0SH30 A0A8C0SH30_CANLF Fe2OG dioxygenase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA alkylation repair [GO:0006307] dioxygenase activity [GO:0051213] TRASLFCWRY 1 2.7 0.99935 -0.61146 0 0 0 0 6.97154 0 0 0 0 0 0 0 0 0 0 A0A8C0SH36 A0A8C0SH36_CANLF C-type lectin domain-containing protein CLEC1A Canis lupus familiaris (Dog) (Canis familiaris) cellular response to molecule of fungal origin [GO:0071226] membrane [GO:0016020] (1->3)-beta-D-glucan binding [GO:0001872] LKIDTAEELEFIVR 1 8.3 0.9847 -0.25747 0 0 0 0 0 0 0 0 10.4937 0 0 0 0 0 0 A0A8C0SH43 A0A8C0SH43_CANLF "TLE family member 3, transcriptional corepressor" TLE3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] EIAKRLNTILAQIMPFLSQEHQQQV;FLSQEHQQQVAQAVERAKQ;MASALRTPISI;QPGQPGFKFTVAE;SIPGGKPA 5 8.4 0.09434 0.87013 10.4834 10.0408 0 0 0 0 10.3565 0 0 0 0 0 10.0596 0 0 A0A8C0SH50 A0A8C0SH50_CANLF Solute carrier family 35 member F2 SLC35F2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ASPAGPGA;RDPRIHLADVA;VLMALSWFILY 3 8.2 1.0028 -1.4892 0 0 11.7434 0 0 6.91193 0 0 0 0 11.7512 0 0 0 0 A0A8C0SH53 A0A8C0SH53_CANLF Potassium voltage-gated channel subfamily A member 10 KCNA10 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] FVVCPSKADFF;IFFLFIGVILFS;IIRLVRVFRIFKLSR;ILRIIRLVRVFRIF;LVNFENSDEIQ;NYFYHRETENEEKQ;VGTLCAIAGVLTIALPVPVIVSN;VTMTTVGYGDMCPV 8 20.2 1.0024 -0.89784 4.51368 0 0 0 0 0 0 10.3537 0 0 0 5.15729 0 0 10.8493 A0A8C0SH63 A0A8C0SH63_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" MAN1A2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" DPRYRQWGW;IRADHEKALEEA;RFTHDPRYRQWGWEAALA;TLKYLYLLFSSDDL;TPTHDDVQQS 5 8.8 1.004 -1.0798 0 0 0 0 0 0 0 0 0 0 0 0 0 9.42771 0 A0A8C0SH64 A0A8C0SH64_CANLF "Inositol 1,4,5-triphosphate receptor associated 1" IRAG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ITCSSAGT;KETAIEQKENCDPLQ;LLYLRITCSSAGTQG;LPGAPPQQKGDE;QHWQVIWMMATVMLVL;RNQNLVGLKLP;SKSGLDVMPNIS 7 8.7 1.002 -1.2796 7.30743 0 0 0 7.89627 0 8.18978 5.05433 0 0 0 0 10.5801 6.65234 0 A0A8C0SH73 A0A8C0SH73_CANLF Gelsolin (ADF) (Actin-depolymerizing factor) GSN Canis lupus familiaris (Dog) (Canis familiaris) actin filament severing [GO:0051014]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015] ATVSRGAAPGRVPE;ATVSRGAAPGRVPEARPSSM;CALLLALC;FQVRASSSG;FQVRASSSGATRA;FVLKTPSAA;FVLKTPSAAYL;GAAPGRVPEARPSSM;GQTAPASTRL;LQVLGPKPALPA;LQVLGPKPALPAG;LQVLGPKPALPAGA;LQVLGPKPALPAGAEDT;LRVLRAQPVQVAEGSEPDGF;PLERAVAE;PLERAVAEL;PLERAVAELA;PLERAVAELAA;PNEVVVQRLF;QTAPASTRL;QVLGPKPALPAGAEDT;RDPDQTDGPGLGY;SVDPLERAVAELA;SVDPLERAVAELAA;TSRDGGQTAPASTRL;VEIMPKAGALNSNDA;VGAGASEAEKSGAQEL;VLKTPSAAYL 28 22.4 0 15.661 14.7463 14.5137 16.1279 12.9399 12.8874 12.995 14.096 14.1084 14.3613 15.5229 15.616 15.7266 16.1344 16.3253 16.3474 A0A8C0SH79 A0A8C0SH79_CANLF Neurexophilin Canis lupus familiaris (Dog) (Canis familiaris) ALPAARDPPRP;EQTQSHVSWLCS 2 4.1 0.98469 -0.2461 0 0 0 0 0 0 9.61346 0 0 0 0 0 0 0 4.63401 A0A8C0SH86 A0A8C0SH86_CANLF Fucosyltransferase (EC 2.4.1.-) FUT7 Canis lupus familiaris (Dog) (Canis familiaris) "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; ceramide metabolic process [GO:0006672]; embryo implantation [GO:0007566]; leukocyte migration involved in immune response [GO:0002522]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration into lymph node [GO:0097022]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neutrophil migration [GO:1902624]; protein glycosylation [GO:0006486]; regulation of cell adhesion molecule production [GO:0060353]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of neutrophil extravasation [GO:2000389]; regulation of type IV hypersensitivity [GO:0001807]; T cell migration [GO:0072678]" Golgi cisterna membrane [GO:0032580]; trans-Golgi network [GO:0005802] 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083] GLGRLGGIFNWVLSYR;LAPHLQVDVFGRANRQ;RQRRVQVYRQL 3 12.3 1.0027 -0.76064 10.0316 0 0 0 0 0 0 0 0 0 0 10.2159 9.41945 0 0 A0A8C0SH92 A0A8C0SH92_CANLF Zinc finger RNA-binding protein ZFR Canis lupus familiaris (Dog) (Canis familiaris) precatalytic spliceosome [GO:0071011] double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] APPPPPPATTQNYQDSYSYV;EENMREGD;KEEYWRRREEEERWRMEMRRYEE;PAAAYGGYPTAHTAT;PAAAYGGYPTAHTATDYGYTQ;SIYPVSSTVQPVAA 6 8.8 1.0046 -1.0945 0 0 8.67412 6.21861 0 0 8.73647 0 0 7.98436 0 4.25384 0 0 8.75629 A0A8C0SH99 A0A8C0SH99_CANLF Ectonucleoside triphosphate diphosphohydrolase 6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] DPILSCLREVMNKT;YSYSYLGL 2 4.6 0.99324 -0.17876 0 9.66345 0 0 0 0 0 0 0 0 0 9.31829 0 0 0 A0A8C0SHA4 A0A8C0SHA4_CANLF HEAT repeat containing 5A HEATR5A Canis lupus familiaris (Dog) (Canis familiaris) DIALAQEMKKRDSRNDF;LAVKSFVSHCGDL;LGAAATPCHRDVYK;LGPELQGNSTSI;LQKRCIEKFK;TTVTCVDTMQEEEGDKG;VEFLCSLRSDATM;VERHKSHRQPLKTI 8 5.5 1.0019 -0.90954 13.557 8.43454 11.8327 0 0 9.52711 0 10.7701 13.5772 0 0 0 9.89289 0 10.4582 A0A8C0SHC0 A0A8C0SHC0_CANLF Pseudouridine 5'-phosphatase PUDP Canis lupus familiaris (Dog) (Canis familiaris) phosphatase activity [GO:0016791] AALAAGMQVVMV 1 5.2 0.95243 0.05044 0 0 0 0 0 0 0 0 0 6.94416 7.01737 0 0 0 0 A0A8C0SHE1 A0A8C0SHE1_CANLF Rho GTPase activating protein 1 ARHGAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] FTWRGPGEEL;IDEKNWPSDEMPDFP;LLGYLKHTLDQ 3 7.5 0.98919 -0.52208 0 9.63023 0 0 9.3357 0 0 0 0 0 0 0 0 0 7.58767 A0A8C0SHF6 A0A8C0SHF6_CANLF Major facilitator superfamily (MFS) profile domain-containing protein LOC489640 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hexose transmembrane transporter activity [GO:0015149] FIQGWFLG;GSVHWLSN;MRHTAQAQESDWWAQ;VCFTACCV;VGPLVNKLGRKGTL;VSIACVICYVVGHALGPS;WAQDHGDGPSAPGLSFSWRARPGC 7 16.6 1.0007 -2.7272 11.2881 0 7.43813 9.14614 0 0 11.8694 6.36143 0 0 0 0 6.07198 0 0 A0A8C0SHF7 A0A8C0SHF7_CANLF Tubulin tyrosine ligase like 12 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] AEPGAPGL;AGRWAGGGRRPRG;GGGGGELC;HFTVMNYDPEVVLKQ;PLRDLDTGEEVTRDFAY 5 7.4 1.0022 -1.2707 10.2104 0 0 0 7.16752 0 0 10.3416 0 0 0 0 0 2.38184 0 A0A8C0SHF8 A0A8C0SHF8_CANLF Transferrin receptor 2 TFR2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to iron ion [GO:0071281]; endocytic iron import into cell [GO:0140298]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of endocytosis [GO:0045807]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein maturation [GO:1903319]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; transferrin transport [GO:0033572] cytoplasmic vesicle [GO:0031410]; external side of plasma membrane [GO:0009897]; HFE-transferrin receptor complex [GO:1990712]; postsynapse [GO:0098794] co-receptor binding [GO:0039706]; transferrin receptor activity [GO:0004998] GTQQWHLEEEEEDGEEGAEPAVHF;IYKRVEGT;KDDTYENLHRVL;NVRIMRVEFYFLSQYVSPADSP;SPYHLGPGP;YGRPEDLQDL 6 10.3 1.0023 -1.8452 0 0 11.3877 0 0 0 10.704 0 9.94141 0 10.7407 11.0144 0 0 0 A0A8C0SHH9 A0A8C0SHH9_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] RNA binding [GO:0003723] GGDRGGSV;QPSLGYGQSNYSYTQQNTY 2 5.3 0.95168 0.049531 0 0 5.30881 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SHI2 A0A8C0SHI2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] AANTDSGV;LVVHMRRHTGEKPHKCT;SPAKGPVATYGPGFAP;VSSSPAKGP 4 4.1 1.0016 -0.6956 0 0 0 8.27896 0 10.07 0 0 0 9.60023 7.54411 0 0 0 0 A0A8C0SHI5 A0A8C0SHI5_CANLF Snf2 related CREBBP activator protein SRCAP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787] AEEQSEEEEDEHSEE;AMELSELAREGEL;DEDGDFQPQ;DEHSEEEETSGSSESEESE;DFQPQEEEEEDDE;DFQPQEEEEEDDEET;DLPLSAASDELLQEPLE;EEDDDFGVE;EETSGSSESEESESEESEES;ETLATGHF;EVATAPDPPPRPKP;FCTLPQPVASP;GAGGISPQHIAQDS;LDDEDGDFQPQEEEEE;LVKRLHKVLRPF;LVKRLHKVLRPFLL;LVKRLHKVLRPFLLRRV;LVKRLHKVLRPFLLRRVKVDV;NEDEAEDEEETIA;NLPLGLGP;RLQPPSPLGPEGS;SEEEEDEHSEEE;VEQLTPIERYA;VIRCRLSKRQRCLYDDFMAQTTTKE;VIRHHEEQRQK;VPRKRAGAP 26 7.9 0.99672 -4.8087 7.83384 0 6.95641 6.52303 5.46182 9.3552 0 10.227 11.0503 8.92425 0 7.24869 10.9293 7.14109 8.28942 A0A8C0SHK5 A0A8C0SHK5_CANLF Desmoglein 3 DSG3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] desmosome [GO:0030057]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AIALIIFALLLLLLVPLLLL;EFLKSYFTEKAA;IALIIFALLLLLLV;IALIIFALLLLLLVPL;IVHQESTSVLLQQ;NLDFSIVVTNKAAFH;TPIPGTIEMLHPW;VQNGTYTA 8 7.3 0.99624 -0.10147 0 7.90509 7.25181 0 7.56742 0 0 4.06324 11.4186 7.96924 10.2681 0 9.81084 8.0587 0 A0A8C0SHK6 A0A8C0SHK6_CANLF RRM domain-containing protein LOC474964 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] NERNARAAVAGEDGRMI;PARVPPPPPIARAV;SLEKIEKEQ;SPLLSSSFDLDY 4 22.4 1.0024 -0.98637 0 0 0 0 0 10.0278 0 0 0 0 0 0 10.2548 0 5.28666 A0A8C0SHM8 A0A8C0SHM8_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DRDLLYSIDAYR;EVVRETEMSVDDDDDINSS;LSSLKTDV;VGSYTLSLSS;VTENQRPGK 5 5.4 1.003 -2.1689 9.67927 0 10.684 0 9.36768 0 0 0 0 0 0 9.92652 0 0 0 A0A8C0SHP8 A0A8C0SHP8_CANLF 24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Canis lupus familiaris (Dog) (Canis familiaris) organic hydroxy compound biosynthetic process [GO:1901617]; small molecule biosynthetic process [GO:0044283]; steroid biosynthetic process [GO:0006694] membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FPEPELFKPERW 1 2.8 0.9539 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.57701 A0A8C0SHR3 A0A8C0SHR3_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "nucleus [GO:0005634]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] EEEFIRNQEQMKPLEEKQEEERSK;GHGPGGGK;HGPGGGKK;VGKKKKKTK 4 8.8 0.97388 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 7.8301 7.215 A0A8C0SHT7 A0A8C0SHT7_CANLF Spectrin beta chain SPTBN2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693] membrane [GO:0016020]; spectrin [GO:0008091] actin binding [GO:0003779]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200] ADEREAVQK;AELQAQWERL;AEVKKHQVLEQALADYAQ;AGEVERTSRAVEE;ETQAWMREKTKVIESTQGLGND;LDALRDQAVALPAALSR;LEVLLFTI;LHMMGQEKAKDELS;LVSQDNFGLELAAVEAAVRKHEA;NHPESTRISI;PERLEDLEVVQQRFETLEPEMNAL;QPPAPEPTARRPEGD;QVQDDGHRLQKAYAGDK;SRRLWRFLWEVGEAEAW;WEERFSALE 15 9.5 1.0006 -2.7591 10.1628 10.0727 0 8.55842 0 0 11.5536 7.4559 9.59801 10.0814 0 0 9.44441 0 0 A0A8C0SHU1 A0A8C0SHU1_CANLF Potassium calcium-activated channel subfamily U member 1 KCNU1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] CSDLHAEDTS;HVLELLQMLVT;ISYFESIYLVMA;PEVSRLCFVK;RFLRALRLLELPQILQILRAIRTS;SSGMFHWC;TFISYYLKSNWLGLRFLRALRLLEL;TKEVVRASL 8 9.5 1.0032 -2.2708 0 7.99294 8.1497 0 8.43275 3.91495 0 0 0 7.55628 0 7.0814 10.9822 0 6.64962 A0A8C0SHW8 A0A8C0SHW8_CANLF Urokinase plasminogen activator surface receptor Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AHLSLTVTLLLT;CFGCEGNSTHGCSSEETSL;LEVVERGCTHPE;PGQDLCRTTIMRIWE;RGCTHPEKSNRTMSYRT 5 23.4 0.99515 -0.11719 0 9.26702 0 0 0 0 0 0 10.4516 0 8.91695 0 0 0 0 A0A8C0SHX0 A0A8C0SHX0_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] EHSWGREKYYP;HSRNRGGSDQDWSRY;ITQALSNP;KKHKKSKKKKKSKDKHRSR;KKKKKKKK;LENPNKPVPSSTVTNS;LQNLGNTCFANAALQCLTYTPP;MFVINEMRRIARHFR;MSQPNGEPIIYVLYAVLVHTGFNC;QATTLVCQIFGGYL;SCSKPVMNGKSKLNSSVL;VKGSTEETSGVWVCTC;YMLSHEHSKTCHAEGFC;YSSSSVPD 14 15.8 0.96457 0.049233 0 0 0 0 0 0 6.45199 0 0 0 0 0 0 0 0 A0A8C0SHX1 A0A8C0SHX1_CANLF Nucleosome assembly protein 1 like 2 NAP1L2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDDNGDDIEATGKENKE;DDEMYDEEEMY;DDGDDDDDDNGDDI;DGDDDDDDNGDD;DSEDYDDEMYDEEEMYGNEE;DVAAGPGD;DYDDEMYDEE;EAAVGPGK;EDDGDDDDDDN;EDYDDEMYDEE;EDYDDEMYDEEEM;EEDDGDDDDDDNGDDIE;GNEEGLVHEYMDEDDGYEGDYY;LSGPGEPLSFTLEFHFK;LVHEYMDEDDGYE;TKEECEYKSDSEDYDDEMYDEEEMY;VEEDDGDDDDDDNGDDIEATGKEN;VLALKKLQTRVANLESKF;YDEEEMYGNEEGLVHEYM;YDYAVEEDDGDDDDDDNG 20 27.5 0.99937 -3.0866 0 6.07288 8.31393 6.83618 7.68447 0 12.8031 8.83194 5.05537 0 8.55401 7.86456 0 8.1091 10.4095 A0A8C0SHX4 A0A8C0SHX4_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PKFHTPMYFFLSHLSF;SYLWGMFGPLVL 2 9.4 0.99379 -0.1318 11.3918 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SHY6 A0A8C0SHY6_CANLF Potassium channel domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) stabilization of membrane potential [GO:0030322] membrane [GO:0016020] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] AGECAVCC 1 2 1.0041 -1.1044 6.27564 0 0 0 0 0 0 0 6.7736 0 0 0 0 0 0 A0A8C0SHZ3 A0A8C0SHZ3_CANLF Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] KALKAKKAVLKGVHSHKKRSLR 1 14.2 0.97403 0.046699 0 0 0 0 5.69566 0 0 0 0 0 0 0 0 0 6.56369 A0A8C0SI13 A0A8C0SI13_CANLF palmitoyl-protein hydrolase (EC 3.1.2.22) LYPLAL1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] CQVLTDLIDD;LEIEKVAFPIVTCNGSRKKKKVL;VLHTQLTSKLVKYLNK 3 20.4 0.92683 0.095486 0 0 0 0 0 0 8.91967 0 0 9.75535 0 0 0 0 0 A0A8C0SI16 A0A8C0SI16_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IDQWNRIGNPEVD;MDAFLESHKL 3 4.1 0.94409 0.061776 0 0 0 0 0 0 10.522 0 0 0 0 0 0 0 0 A0A8C0SI17 A0A8C0SI17_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] CGSCQSYQESTKQLTM;DENKYSLF;HSAKQRRKITTY 3 6.5 0.98773 -0.48805 0 0 0 0 9.55875 0 0 0 0 0 0 0 0 0 0 A0A8C0SI30 A0A8C0SI30_CANLF BTB domain-containing protein KCNC4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] EEELTFWGIDETDVEPCCWMTYRQH;EPCCWMTYRQHRDAEEALDIFE;GDGGGGGG;GGGGGGGG;GSVRKETCHDAL;KKRKKHVPRPPQ;LTIAMPVPVIV;VVRFVRILRIFKLTRHFV 8 16.2 0.86481 0.18312 3.85469 0 0 0 0 0 0 0 0 0 0 7.05083 0 8.01764 0 A0A8C0SI36 A0A8C0SI36_CANLF Solute carrier family 16 member 4 SLC16A4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ATNIPFLCVTMGLLP;GSFYFSGTCYL;MIVFHFFLVNV 3 7.7 0.9886 -0.50608 0 0 0 0 0 0 0 0 3.63215 9.06803 0 0 0 0 0 A0A8C0SI45 A0A8C0SI45_CANLF "Signal peptide, CUB domain and EGF like domain containing 1" Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] DECQDNNG;DNNGGCQQICVNAMGSYE;LYGTTHCGDVDECSMNNGSCD;NNGSCDGC;RDGRLYASENHQEILKDKKLIKA;VGTYQPEPGRTGCFSCGGGLLTK;WNQKDCVEMGKCLSRAKASPWAQL 7 11.7 1.004 -2.0254 6.91707 7.70625 0 0 0 3.98103 8.03897 9.22538 8.34141 0 0 0 5.49416 5.51523 0 A0A8C0SI50 A0A8C0SI50_CANLF "Neural proliferation, differentiation and control 1" NPDC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ELESLSSDEENEDGDFTVYECP;HLRLLRLLL;LFDHSSLS 3 12.2 1.0022 -1.2672 0 3.90862 0 0 0 0 0 0 0 0 0 5.26206 0 0 0 A0A8C0SI56 A0A8C0SI56_CANLF Phosphodiesterase 12 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] GEAVLPGG;LIQKELTGYNADLIC;SGRAEGGG 3 5.1 1.003 -2.5006 0 0 0 0 0 0 10.742 0 0 0 0 8.38828 0 0 0 A0A8C0SI63 A0A8C0SI63_CANLF Huntingtin interacting protein 1 HIP1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] cytoplasm [GO:0005737] actin binding [GO:0003779]; clathrin binding [GO:0030276]; phospholipid binding [GO:0005543] AIPAAGLREKRP;EFYAKNSRWTEGL;ELQIVQGS;GTASPKEFYAKNSRW;HYELAGVAEGWEEGTEAS;IPAAGLREKRP;LHSCLPADTLQ;SEAKWAAQIAE 8 6.3 1.0017 -1.3137 0 0 11.4765 9.73179 6.4268 8.14098 11.8062 0 0 0 12.0459 12.0304 11.4167 11.0914 11.6719 A0A8C0SI72 A0A8C0SI72_CANLF Euchromatic histone lysine methyltransferase 2 EHMT2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] histone H3 methyltransferase activity [GO:0140938]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; zinc ion binding [GO:0008270] AGTFLECH;EEEEEEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEEESGNQ;GVGSSGPS;HCCPGCGY;QPPVPEKRPPEVQHFRM;SEEEEEEEEEEEEEEEEEEEEEEEE;SLYYDSYSVDERVDSDSKSEVEA;VLCETHRAR;WAPQLPSGLTSP 10 9.2 0.97402 0.046699 0 0 0 0 0 4.19172 0 0 0 0 0 6.9431 0 0 0 A0A8C0SI75 A0A8C0SI75_CANLF Lutropin-choriogonadotropic hormone receptor LHCGR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] luteinizing hormone receptor activity [GO:0004964] GPALLLPVLLLLLLLLP;GPALLLPVLLLLLLLLPPRARP;GPALLLPVLLLLLLLLPPRARPG;LLLLLLLL;LLLLLLLLP;LLLLLLLP;LLLPVLLLLLLLLPPRARPGPP;LPVLLLLLLLLPPRARP;PALLLPVLLLLLLLLPPRAR;PRGPALLLPVLLLLLLLLPPR;VLLLLLLLL;VLLLLLLLLPPR;VTVLFVLLTSRYKLTVPR 13 6.7 0.59524 0.37792 5.02241 0 0 6.39931 0 0 0 0 8.23793 7.76971 6.58304 0 0 7.65306 7.72846 A0A8C0SI79 A0A8C0SI79_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LDQLNFMEQVRE 1 3.4 0.94458 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 9.55685 0 0 A0A8C0SIE0 A0A8C0SIE0_CANLF IRF tryptophan pentad repeat domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] ESETTDSV;IIVVGQSHL;NWAIHTGK;SYAESETTDSVPSDEE;VGTMPVERMRMRPWLEEQINSNTI 5 14.5 1.0032 -1.6291 11.3382 0 0 0 0 5.73533 0 9.09379 0 0 0 7.26322 0 0 0 A0A8C0SIG3 A0A8C0SIG3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PAVSLLQDWSKHPQGTKSV;PRSVRMEEPPAV 2 8 0.99382 -0.07463 9.8996 0 0 0 0 0 10.1538 9.85787 0 0 0 0 0 0 0 A0A8C0SIH3 A0A8C0SIH3_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; transferase activity [GO:0016740] SQCQPRPRDTMVKFGVN 1 5.1 0.9767 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.55674 A0A8C0SIH4 A0A8C0SIH4_CANLF ribonuclease III (EC 3.1.26.3) DROSHA Canis lupus familiaris (Dog) (Canis familiaris) pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; rRNA processing [GO:0006364] microprocessor complex [GO:0070877] ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723] CKGMIVTNPG;DLESSSESECESDEDST;LFLFRDILELY;MLQWEELEWQKY;PPPETVNHH;QPPVQYQYEP;TNIPLCKV;YNFPQMAHQKRFIE;YNFPQMAHQKRFIERKYRQELKEMR;YPGEEAIKPCR 10 8.1 1.0011 -2.7156 11.0392 0 5.98105 0 8.35883 0 0 0 10.0912 0 0 0 9.9218 8.41092 12.0172 A0A8C0SII1 A0A8C0SII1_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) system development [GO:0048731] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GGGGGGGA;GGGGGGGG;RGWGPFKR;VPVCVGGG 4 3.1 1.0034 -2.2088 0 3.65547 10.4684 0 0 0 0 6.96128 0 0 10.2657 4.12052 0 10.9038 0 A0A8C0SIJ7 A0A8C0SIJ7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MKRRDTCTPMFLAAMDTIAKLWKEP 1 3.4 0.99236 -0.29509 0 0 0 0 0 0 0 0 0 0 0 0 8.437 0 0 A0A8C0SIJ8 A0A8C0SIJ8_CANLF SH3 and cysteine rich domain STAC Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383] metal ion binding [GO:0046872] EDGVDGLPQEAPSA;MVAVHLDLYICIEDSLV 2 7.6 0.98766 -0.48043 0 0 0 9.56476 0 0 0 0 0 0 0 0 0 10.5468 0 A0A8C0SIJ9 A0A8C0SIJ9_CANLF Chloride anion exchanger (Solute carrier family 26 member 3) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] antiporter activity [GO:0015297]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271] ILRKRNKALKKIRKL;KALKKIRKLQK;KDSIFFLTI;LPFQIDWNADLPL;LRKRNKALKKIRKL;LRKRNKALKKIRKLQ;LRKRNKALKKIRKLQKKGLLQMTP;LTVPAHTDPFSIF;PLRILRKRNKALKKIRK;PLRILRKRNKALKKIRKLQKKGLLQ 10 8.3 1.0015 -0.69493 0 0 7.37356 6.07446 0 0 10.1205 10.1783 7.87971 10.1035 0 0 0 6.02713 1.70341 A0A8C0SIK2 A0A8C0SIK2_CANLF Myocilin MYOC Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; rough endoplasmic reticulum [GO:0005791] metal ion binding [GO:0046872] GGYTDIDLA;PASRILKE;QTWETNIRKQSVAN;TLELEQTWE 4 7.5 1.0022 -1.457 8.53201 0 7.00405 0 0 0 0 0 0 0 0 8.29154 0 8.28462 0 A0A8C0SIK4 A0A8C0SIK4_CANLF Rho GTPase activating protein 32 ARHGAP32 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] phosphatidylinositol phosphate binding [GO:1901981] AAAEVESPGKEEQVVSSSQSK;GILKERVFGCDLGE;GRNASGHHPKPCSRVEYVSSL;IHDVIQQLP;PGTSQAAYTNYGD;SEPSEMKAMALKG;VSKGQLVKMDIRV;VSSPIVTENKYI 8 5.5 1.0042 -1.0927 0 0 9.53695 10.5736 0 0 8.79799 7.48212 0 0 0 8.25687 7.20867 0 10.944 A0A8C0SIK7 A0A8C0SIK7_CANLF Kielin cysteine rich BMP regulator Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ARDDCCPACDGCEYLGE;CDGCFLNGREYRSGEP;CSCHDGMPMCGAVL;EGAITCTQKPCPEGPCPEPGACC;EPDGQPCTACSCHDGMPMCG;GEVSCEEQECP;GPCCPSCDGC;GPCPEPGACCPHCEPGCEY;HPSDPCRQCHCLSGSVQCLA;HQGRAVAPGERWAVDL;PGQCCPVCDGCE;PSCESCTYH;PSLPHCHGCSHHGQA;QVSCVRLPCP;RPGGGGPA;SEETFRLQESGR;SSCMCHEG;VLSDCCPRCSDCEHEG;VPPEPFFAACVYDLCACGP;VQCEPLPCPPVPCRYPGRTPG 20 16.8 0.99903 -3.0461 4.22974 10.4655 6.68958 8.68965 0 9.83056 7.08321 8.11515 3.15531 10.9169 10.0966 0 9.28711 0 10.7407 A0A8C0SIM7 A0A8C0SIM7_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AEPPAPAFRRA;EVVQEHAAESI;GVPARPAGT;IQIEGYMPLDCMFCNQ;RQRRRQRLRRAPL;TDNDDSCSEKEE;VEAEYLSPLDK 7 8.6 1.0047 -0.80421 0 0 0 7.35746 0 7.672 0 0 0 0 7.19259 0 0 0 0 A0A8C0SIP8 A0A8C0SIP8_CANLF SUZ-C domain-containing protein LARP6 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] GGRGGGGG;VEELQYMGDESS 2 3.2 0.95225 0.05044 0 0 0 0 0 0 0 0 0 0 8.51877 0 0 0 0 A0A8C0SIQ6 A0A8C0SIQ6_CANLF "PMS1 homolog 2, mismatch repair system component" PMS2 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] mismatch repair complex [GO:0032300]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] GVMCRPSRVR;LSSLCALSDV;LVNEVYHMYNR;RKNGFDFVIDEGAPVT;SVCEEYGL;YGLNRADVLHSRFH 6 7.9 1.0031 -2.3053 0 6.66775 7.77643 0 0 0 0 6.93664 0 0 0 0 8.13965 0 0 A0A8C0SIQ8 A0A8C0SIQ8_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cellular response to vascular endothelial growth factor stimulus [GO:0035924]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; response to cytokine [GO:0034097]; toll-like receptor signaling pathway [GO:0002224]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019] CGYPPFYS;DMWSLGVIMYILL;GPEGGQGAVGGCQGEG;SEEGKDPLPHPVHVHMRAH 4 10 0.99292 -0.1603 0 0 7.45861 0 0 9.08468 0 0 0 0 0 0 0 0 0 A0A8C0SIR3 A0A8C0SIR3_CANLF IRG-type G domain-containing protein IRGQ Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] AALARGTPLLAV;DETWEVLEEAPPPVF;EPVFMPAGPTPH 3 6.2 0.99625 -0.58051 0 0 0 0 0 0 13.1031 0 0 0 0 0 0 0 0 A0A8C0SIU4 A0A8C0SIU4_CANLF Mitogen-activated protein kinase 8 interacting protein 2 MAPK8IP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of JNK cascade [GO:0046328] cytoplasm [GO:0005737] AACSEEDEEDEED;ACSAACSEEDEEDEED;GRACSAACSEEDEEDEEDEAA;LSYDSDHCEKDSL;LVNGEEKE;PGPAQPGPCLFLSN;PMHPGCDCEG;QDDFQEFEMIDDNEEEEEEEEEEEE;QEFEMIDDNEEEEEEEEEEE;QEFEMIDDNEEEEEEEEEEEEEE;RPPQDISLEEFDD;SAACSEEDEEDEEDEA 12 12.9 0.99652 -0.57302 0 0 13.0928 0 7.23659 0 8.94248 7.10003 0 0 0 0 5.88489 7.17043 11.9435 A0A8C0SIU6 A0A8C0SIU6_CANLF GYF domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AFGRNPREIQRSQSWDDRGERR;DGFEEDKDGLPEWCL;QDKEFAAVLQEEPLQ;RRDGARSGFEEGG;RSRGRGRGDS 5 7.3 1.0037 -1.0431 0 6.67694 9.63512 0 0 0 0 0 0 0 9.16002 0 0 9.6423 0 A0A8C0SIW1 A0A8C0SIW1_CANLF Family with sequence similarity 91 member A1 Canis lupus familiaris (Dog) (Canis familiaris) KDERKYYEELLKYS;RNTILFLRHN;SEKSYDSLPNFT;STLDVPTEASFSSVL;VTMFEVGK 5 7.5 1.0005 -0.6125 0 0 9.53555 0 0 0 0 0 10.0596 0 8.48079 8.47204 0 0 0 A0A8C0SIW2 A0A8C0SIW2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ITSFVFTCFCFLHYNC;ITSFVFTCFCFLHYNCM 2 4.7 0.92516 0.09546 0 0 0 4.11045 0 0 0 0 0 0 0 4.98691 0 0 0 A0A8C0SIW6 A0A8C0SIW6_CANLF Olfactory receptor OR5D18 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NSKNSRHTVKVA 1 3.8 0.95206 0.05044 7.48494 8.40284 0 0 0 0 0 9.27356 0 0 7.67044 0 0 9.35797 0 A0A8C0SJ32 A0A8C0SJ32_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FDAWNIMKSVPEG;LSCPVRPAAGACPAGSGPK;LSIPNASQ;RTGPAAVLFRT;RVYKGGAA;SIPNASQPFSVLDVSS;VLSSVGSKSTV;YHSEQNYESTSFFSVK 8 7.7 0.98163 0.035491 0 0 0 0 0 0 0 0 0 0 11.6965 0 0 0 0 A0A8C0SJ55 A0A8C0SJ55_CANLF PAP-associated domain-containing protein TENT4B Canis lupus familiaris (Dog) (Canis familiaris) RNA metabolic process [GO:0016070] poly(A) RNA polymerase activity [GO:1990817] AAVPVPVPVP;LYFNHHCHSSGGASGGGGGSS 2 4.8 1.0024 -0.90006 0 0 4.14274 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SJ57 A0A8C0SJ57_CANLF Cell death-inducing p53-target protein 1 (LITAF-like protein) CDIP1 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771] cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; nucleus [GO:0005634] zinc ion binding [GO:0008270] CGGDCSCCC;CGGDCSCCCG;PSDRRETASCGGDCSCCCGR;SCGGDCSCCC 4 7.8 1.0029 -1.1613 0 4.86631 0 0 0 0 0 0 0 0 4.1959 0 0 0 4.48065 A0A8C0SJ59 A0A8C0SJ59_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] ATVAEAVAEASVAEAEAEVEA;GEATAALAVG;VGDLHPEVTEAMLYEKFSPAGPI 3 13 1.0039 -0.8292 0 0 6.06667 0 0 0 11.8147 0 0 10.3107 10.6568 0 10.0157 10.0264 0 A0A8C0SJ73 A0A8C0SJ73_CANLF Acetyl-CoA carboxylase kinase (EC 2.7.11.1) (EC 2.7.11.31) (Hydroxymethylglutaryl-CoA reductase kinase) PRKAA1 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; cholesterol biosynthetic process [GO:0006695]; intracellular signal transduction [GO:0035556]; rhythmic process [GO:0048511]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737] AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524] EVCRAIKQLDYEWKVVNPYYL;QNLKLFRH 2 5.2 0.98498 -0.24692 9.17819 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SJ90 A0A8C0SJ90_CANLF TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TAB2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130] DGQLQGGQSNNEL;GVVSPTFELTNL 2 3.8 0.99645 -0.57451 0 0 0 0 0 0 0 10.6228 0 0 0 0 0 0 0 A0A8C0SJ93 A0A8C0SJ93_CANLF 40S ribosomal protein S16 RPS16 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" cytosolic small ribosomal subunit [GO:0022627] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] CRMAGIPIWKFRIF;VGSQPEPHL 2 6.1 0.98471 -0.24627 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.35817 A0A8C0SJA6 A0A8C0SJA6_CANLF Zinc finger C2HC-type containing 1C ZC2HC1C Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EIRRKETLLREKLKKTEEELRRIQK;KENEKRELQRMTL;LSNKELTLDN 3 9.9 0.99267 -0.17142 0 0 0 0 9.79193 0 0 5.29436 0 0 0 0 12.2012 0 0 A0A8C0SJB9 A0A8C0SJB9_CANLF Assembly factor for spindle microtubules ASPM Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; establishment of meiotic spindle localization [GO:0051295]; mitotic cell cycle [GO:0000278]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle pole [GO:0000922] calmodulin binding [GO:0005516] DERWKEKQ;ILMKDNSMP;IQSMFRRWKRRKMQLQIKATRVLQR;KAVRRFLLRKK;KRQYYLEIYKATL;NQFVKDNMA;RGWLVRKRILEQRTKIRL;RRFQKIKDSTIKIQ;RYKGRQVF 9 3.3 1.003 -2.4154 0 0 0 0 0 0 11.4697 10.1307 7.37339 0 6.65807 3.38211 8.88053 0 0 A0A8C0SJC9 A0A8C0SJC9_CANLF Beta-sarcoglycan SGCB Canis lupus familiaris (Dog) (Canis familiaris) muscle organ development [GO:0007517] sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] GPNGCDSM 1 2.5 1.0041 -1.1044 0 5.06178 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SJE0 A0A8C0SJE0_CANLF Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] glycosyltransferase activity [GO:0016757] EEYGHDLLHTV;LLKRIIKWTVTHSFTAY 2 4.5 0.98553 0.046227 0 0 0 0 0 0 0 0 7.62373 0 0 0 0 0 0 A0A8C0SJF7 A0A8C0SJF7_CANLF Mannose receptor C type 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] ATTQDYGKDERW;DPQDRVKWSE;DTSGGWQWSDNSPLKYLNW;HWWIGLHTAESD;LMAVLLLLALLTAALILYRRRQ;MLNKIFGESEP;MLNKIFGESEPEIHEQ;NWESDQPDNPSEENCGVI;PSLSPSPAASPPAPGTELS;QEVEELWIGL;RGTDVREPDVSPQGRREWLRFQDTE;TGSCPQGWGSDPK 12 12.5 1.0022 -1.8773 0 0 8.85487 0 0 0 11.6013 0 8.58553 8.12153 6.19288 8.59317 0 7.24793 9.06813 A0A8C0SJH9 A0A8C0SJH9_CANLF Olfactory receptor OR4C6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HLTVVVLFFV;MTQLFAEHFFGGVGIILLIV 2 9.6 0.98783 -0.22702 0 0 0 0 0 0 13.0185 6.82972 0 0 0 0 0 0 0 A0A8C0SJI1 A0A8C0SJI1_CANLF "inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57)" INPP1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] CLRAGPGAGLEPP;DCCAAHAILRAMGGGV 2 7.5 0.99322 -0.15978 0 0 0 0 0 0 0 0 0 10.7083 0 0 0 0 0 A0A8C0SJK9 A0A8C0SJK9_CANLF ADP-ribosylation factor GTPase-activating protein 3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] GTPase activator activity [GO:0005096] GVHLSFIRSTE;VGAWPDRHAQP;YETRARLERLSASSSISSAD 3 6.5 0.98808 -0.4921 6.20856 0 0 0 0 0 0 0 0 10.1239 0 0 0 0 0 A0A8C0SJN2 A0A8C0SJN2_CANLF Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] glycosyltransferase activity [GO:0016757] EEYGHDLLHTV;ETKVTHYKQYPPN 2 4 0.92398 0.095355 0 9.37016 0 0 0 0 0 0 0 0 0 8.49277 0 0 0 A0A8C0SJN8 A0A8C0SJN8_CANLF dynamin GTPase (EC 3.6.5.5) DNM3 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; receptor internalization [GO:0031623]; synaptic vesicle endocytosis [GO:0048488] cytoplasm [GO:0005737]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; presynapse [GO:0098793] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] IVKLKGPSLKSVDLV 1 1.8 0.95704 0.053874 0 0 0 0 0 0 0 0 0 0 0 4.45437 0 0 0 A0A8C0SJR0 A0A8C0SJR0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PAK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FLNRCLEMDV;NEILVMRENKNPN;VDIWSLGIMAIEMIEGEPPYLNENP;VGDELWVVMEY;VLDVLEFYNSKKTSNSQ 5 14.6 0.98364 0.046227 0 0 0 0 11.7448 0 0 0 0 0 0 0 0 0 0 A0A8C0SJR7 A0A8C0SJR7_CANLF Enhancer of rudimentary homolog Canis lupus familiaris (Dog) (Canis familiaris) ECMEGVCKMYEEHL;IDDLADLSCLVYRADTQ 2 29.8 0.93113 0.10761 6.97166 0 0 0 0 0 0 0 0 0 0 0 7.73775 0 0 A0A8C0SJT1 A0A8C0SJT1_CANLF Transporter SLC6A17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] EAGGKQKAAEEELDAEDRP;EDRPAWNSKLQ;GTGLAFIA;KAAEEELD 4 4.9 1.0025 -1.7676 0 0 0 0 0 9.53177 5.07258 0 6.37718 0 0 0 0 0 0 A0A8C0SJW7 A0A8C0SJW7_CANLF Zinc finger protein 764 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DAADSRNKEEERQ;VGFQHYPEI 2 5.4 0.94012 0.059561 0 0 0 0 0 0 0 0 3.21383 0 0 0 0 0 0 A0A8C0SJW8 A0A8C0SJW8_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] PVLFSSIKF;VEGNISVSSQCAVCHENCGSY 2 2.5 0.99014 -0.31404 0 0 0 0 0 0 0 0 0 0 0 0 0 9.1708 0 A0A8C0SJZ1 A0A8C0SJZ1_CANLF asparaginase (EC 3.5.1.1) ASPG Canis lupus familiaris (Dog) (Canis familiaris) aspartate family amino acid metabolic process [GO:0009066] asparaginase activity [GO:0004067] GLGPACKG;LVVHSSMERDV;QEADAVRDALLPGLACAAAHAGNLE;TELCRLAA;VPVDTRDEDGLSPL 5 10.8 1.0035 -2.0582 8.35716 0 10.9358 8.88099 9.11215 0 0 8.75495 11.0295 0 10.238 10.132 10.5217 10.4693 10.5672 A0A8C0SK14 A0A8C0SK14_CANLF STIL centriolar assembly protein Canis lupus familiaris (Dog) (Canis familiaris) ATLKQLRSL;KVNKNAHK;LASWSQPHNF;LTEQDRQLRLLQAQI;NENQLSQLSLTR;SYCPTNVCGCCQ 6 5.5 0.98843 -0.26067 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1672 0 A0A8C0SK15 A0A8C0SK15_CANLF "T cell activation inhibitor, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) EKFYKEPSVSSKQMVD;VHHHWTKL;VINGCLGVDIHIY 3 6.3 0.93682 0.059565 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.58367 A0A8C0SK18 A0A8C0SK18_CANLF CE022 protein Canis lupus familiaris (Dog) (Canis familiaris) DQLENQKPLQLDVI;FVLDIDLDFFS;GQTCLEQSCSCFSE;ICSSAILDTWLPEFSWRISLCH;IENWIMPAVYAG;LLKNLPKPTL;LPSGKAAGDAAAGRAGLRRYPAL 7 21.5 1.0026 -1.3552 0 0 10.0158 0 0 7.52615 0 0 0 0 0 0 4.863 0 0 A0A8C0SK45 A0A8C0SK45_CANLF Assembly factor for spindle microtubules ASPM Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; establishment of meiotic spindle localization [GO:0051295]; mitotic cell cycle [GO:0000278]; spindle organization [GO:0007051] cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle pole [GO:0000922] calmodulin binding [GO:0005516] DERWKEKQ;ILMKDNSMP;KAVRRFLLRKK;NQFVKDNMA;RGWLVRKRILEQRTKIRL;RYKGRQVF;SIIQAVWRSYKARKYLHQ 7 4.3 0.9744 0.048313 0 0 0 0 0 0 8.91886 0 0 0 0 0 0 0 0 A0A8C0SK48 A0A8C0SK48_CANLF Calponin-homology (CH) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAATTSVPGAPGLPGSR;GAPGLPGSRSAERALE;RDLSVRRN;VGGRAPRPSGP 4 6.5 0.98626 -0.45469 0 0 0 0 0 8.00006 9.73225 0 10.4217 0 0 0 0 0 0 A0A8C0SK64 A0A8C0SK64_CANLF Sushi domain-containing protein CFHR5 Canis lupus familiaris (Dog) (Canis familiaris) FHCNFPKINHGI 1 2.1 0.98416 -0.25511 0 0 0 0 0 8.84194 0 0 0 7.60021 0 0 0 0 0 A0A8C0SK68 A0A8C0SK68_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPCICDWLWWVET;LWWVETGQNIT 2 8.3 0.99255 -0.2824 8.22516 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SK75 A0A8C0SK75_CANLF Cadherin domain-containing protein DSC3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] IALLFSVLLTLV;LDREAMAPRNELYNI;SGSIITSKILDREAMAPR;VLSDEKRSFTI;VLSDEKRSFTIWLSDTKTQ 5 6.6 0.99311 -0.047114 10.3839 0 0 8.0587 0 8.87523 0 10.6631 0 0 0 0 0 8.35248 11.2036 A0A8C0SK78 A0A8C0SK78_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;IMNEKAEITTN;MDAFLESHKL 3 3.8 0.99402 -0.19102 0 0 0 0 0 0 0 10.4607 0 0 0 0 0 0 0 A0A8C0SK99 A0A8C0SK99_CANLF Outer dense fiber of sperm tails 3B ODF3B Canis lupus familiaris (Dog) (Canis familiaris) VGSFCEDL 1 4.3 1.0041 -1.1044 0 0 0 0 0 0 0 0 6.95722 0 0 0 0 0 0 A0A8C0SKA9 A0A8C0SKA9_CANLF Protein S100 (S100 calcium-binding protein) S100G Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; transition metal ion binding [GO:0046914]; vitamin D binding [GO:0005499] SPEELKSIFEKYAAKE 1 20.3 0.96086 0.049233 0 9.33188 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SKB6 A0A8C0SKB6_CANLF Phosphoinositide-3-kinase regulatory subunit 6 Canis lupus familiaris (Dog) (Canis familiaris) "phosphatidylinositol 3-kinase complex, class IB [GO:0005944]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] ELQNVELDLQRSV;VIIPLLHT 2 2.8 0.98907 -0.51847 0 0 0 0 0 9.40318 0 0 0 8.79705 0 0 0 0 0 A0A8C0SKC1 A0A8C0SKC1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RLIM Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; transferase activity [GO:0016740] FGENDALKTCSVCI;GDFRFSLEINVNRNN;PCSHEYHVHCID;SQMDRLDREEAFYQF 4 9.4 1.0011 -0.63965 12.1773 5.83357 10.6071 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SKD4 A0A8C0SKD4_CANLF ABC transporter domain-containing protein ABCA14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CRMEMKQYGVQW;ETTSWKVRTFVYLW;GVGYHIII;LMIGLSNAMLWASY;LYKEFTTE;WDNILSPVNPHDS;YSISQITLEEVF 7 5.3 0.93719 0.060945 0 0 0 0 0 4.70769 0 0 0 0 0 0 0 0 0 A0A8C0SKE7 A0A8C0SKE7_CANLF Ly1 antibody reactive Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AKGAADRAEEGEAEESRKAR;CECLSCMDCGK;CMDCGKDFWGD;EAKGAADRAE;RNCECLSCMDC;YEGKTHKG 6 14.6 1.0021 -1.3015 0 4.20375 0 0 0 0 12.1206 6.87848 4.43789 0 6.84825 9.36573 3.6589 0 6.47442 A0A8C0SKE9 A0A8C0SKE9_CANLF Solute carrier family 5 member 9 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] CTDQVIVQRSL;LYIFTKISTDIFSG;PEDAAARSQALT 3 5.4 0.98361 -0.25256 8.54547 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SKF3 A0A8C0SKF3_CANLF Ski2 like RNA helicase SKIC2 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]" Ski complex [GO:0055087] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EQALDELTKRLGALEEPDTTGQLVD;ISPPEPPKPVPQEQ;LPEGPCDH;PGEYVQMAGRAGRRGLDPTGTV;TLDPVNDLQLKD;TVPNALEFADWIGR 6 7.6 1.0026 -0.89721 0 0 0 12.271 11.5355 12.6668 0 11.369 11.0356 0 0 10.7974 10.2963 10.2913 0 A0A8C0SKG4 A0A8C0SKG4_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein localization to plasma membrane [GO:0072659] apical plasma membrane [GO:0016324] protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102] GVTMKAGVLAG;WQKNELTVQPHILLPILK 2 10.2 0.99444 -0.19065 0 0 0 0 0 0 0 0 8.56967 0 0 0 4.4004 0 0 A0A8C0SKI2 A0A8C0SKI2_CANLF Immunoglobulin V-set domain-containing protein FCMR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GWGGGGGL;LLMKRVIQRRKALSRRARRAAVRMR;LPDRGGAYPRP;TTLALILLALLGLLMKRVIQRRKA;VPTTLALILLALLGLLMKR;VTELTKSDSGIYACG;WGGWGGGG 7 13.4 1.0018 -1.2515 9.24843 0 0 0.287472 0 0 10.5994 0 0 0 0 4.86374 4.52669 0 0 A0A8C0SKL1 A0A8C0SKL1_CANLF Shortage in chiasmata 1 SHOC1 Canis lupus familiaris (Dog) (Canis familiaris) resolution of meiotic recombination intermediates [GO:0000712] condensed nuclear chromosome [GO:0000794] ATP hydrolysis activity [GO:0016887] CEPEYSEP;ELDVKLIIAPG;FLIKDPILDFKEQ;HYSDIGETVYEDT;LDFKEQIFTEAN;QIFTEANFFREHFSFQGDLKSL;TETLELLNTYLSGN;YHYSDIGETVYEDTNSTSN 8 6 1.0022 -1.8633 9.56841 10.4828 10.6873 0 0 8.65474 0 0 0 6.16529 2.82721 0 0 8.02791 0 A0A8C0SKL3 A0A8C0SKL3_CANLF Ig-like domain-containing protein LRRC4C Canis lupus familiaris (Dog) (Canis familiaris) modulation of chemical synaptic transmission [GO:0050804]; regulation of axonogenesis [GO:0050770]; synaptic membrane adhesion [GO:0099560] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] cell-cell adhesion mediator activity [GO:0098632] DLFTPLHHLE;DLGELKRLSYISEGAF;LDELDLSG;LLVVAGLVRAQ;LWLRNNPIESIPSYAFNRIPS;NSYKSPFNHTTTVNT;VIVEPPAD;WWIKDMAPSNTACCARCNTPPN 8 17.3 0.98897 -0.52279 9.81594 11.1381 9.73571 9.84731 0 10.3325 10.7668 0 9.85563 0 10.398 0 9.25068 11.2636 9.6912 A0A8C0SKL7 A0A8C0SKL7_CANLF Ovostatin homolog 2-like Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GLFCLEEALEDGV;HVLFYLETVFGTANHFTFSV;KASGFSLS;LVSNIQPAPVMVYDYYEKGR;NFTFPALRNGL;NVLLPKKASGFSLSL;TFPALRNGLF;TTDENGEALFSIDTSDIFD;VPIIILSIFL;YIPVSNYGD 10 8 1.0028 -2.4721 9.71488 0 11.0825 0 0 0 13.2648 7.87596 8.81618 13.5914 0 0 0 0 0 A0A8C0SKM8 A0A8C0SKM8_CANLF Proline rich 5 like PRR5L Canis lupus familiaris (Dog) (Canis familiaris) FITDYFQNQLLAKG;LLAMATRMHPGLGEEPGGDD;RYGLFISSACLSGSPQAPG;TDYFQNQLLAKG;VINVFKGGGLQSNELYALNE 5 18 0.95021 0.049691 0 0 0 0 0 0 0 0 5.46444 0 0 0 0 0 0 A0A8C0SKS4 A0A8C0SKS4_CANLF Diaphanous related formin 2 DIAPH2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] DKKNQYKLIQCLKAFMNNK;EQEKLERQKKKKQ;EYDDLCEPEQFGV;FEKMMEDMNL;ILPAKKKVKELRIL;LPPGGGIPPF;RNNKERFSPIVEG;SEEKKILPAKKKVKELRI;SGAAFRDRRKRIPRNS;YYIRPQYYKIIEECISQ 10 11.8 1.0023 -1.4409 0 0 6.91433 11.0549 0 0 0 6.66249 8.36014 0 0 0 8.94758 0 0 A0A8C0SKS8 A0A8C0SKS8_CANLF BAT2 N-terminal domain-containing protein PRRC2C Canis lupus familiaris (Dog) (Canis familiaris) APHTNTFPAPVQ;ASGVSSSASGPSTANYN;DARPEAPLDQEQIT;EQLNFSDDDEQGSSSPKENSSEDQG;ETDTDSEVH;PTVKEEKQP;QAKLNGQQPPLASQYRAMMPPY;RGNSGPPKSGRNFSGP;RSGPIKKP;SAQTPNGTEYVATGKSI;SETRSESS;SKTNEVAVPANGTVNNVVQEP;YRGSYGGRGRGGRGH 13 6.8 0.99898 -2.96 0 8.97599 8.71266 0 0 0 8.60885 9.22983 0 0 0 0 0 9.58007 7.56932 A0A8C0SKS9 A0A8C0SKS9_CANLF SCP domain-containing protein CLTA Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CTRSPRCLWGSGPRG;ERAERAMGKSASKQFNN 2 8.5 0.99105 -0.18532 0 0 0 0 0 0 0 0 12.0121 0 0 0 8.68229 0 0 A0A8C0SKT8 A0A8C0SKT8_CANLF SAP domain-containing protein SF3B2 Canis lupus familiaris (Dog) (Canis familiaris) U12-type spliceosomal complex [GO:0005689] APKLSKKKLRRMNR;EDTVSVSKKEKNRKRRNRKKKKK;EEEHKDSDDDS;IDRTPWGELEPSDEESSEEEEEE;QQEEEEMETDTRSSL;TVSVSKKEKNRKRRNRKKKK;VGGAMMGST 7 10.8 1.0026 -0.84182 0 0 6.17546 7.33887 0 8.41616 0 2.47423 9.69693 0 0 7.39472 0 0 7.88564 A0A8C0SKU2 A0A8C0SKU2_CANLF Nuclear receptor subfamily 2 group E member 3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] EAWSELFLLGA;EHVEALQDQSQVMLS;FMASLITAETCA;LEEAWSELF 4 12.9 0.9922 -0.20823 0 0 0 8.86817 0 0 0 0 9.06013 9.3981 0 0 0 0 0 A0A8C0SKU3 A0A8C0SKU3_CANLF Serine/arginine repetitive matrix 5 Canis lupus familiaris (Dog) (Canis familiaris) VERDAEQGKERPV 1 1.8 0.98989 -0.26167 0 0 0 0 0 0 0 0 0 0 0 0 9.14172 0 0 A0A8C0SKU5 A0A8C0SKU5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLVSFFCMWMSNFPS 1 12.9 0.99081 -0.21081 0 0 0 0 0 0 0 0 0 0 9.15573 0 0 0 0 A0A8C0SKV8 A0A8C0SKV8_CANLF asparaginase (EC 3.5.1.1) ASPG Canis lupus familiaris (Dog) (Canis familiaris) aspartate family amino acid metabolic process [GO:0009066] asparaginase activity [GO:0004067] CVHGLEGGQGCRASPG;LVVHSSMERDV 2 3 0.98968 -0.2229 0 0 9.50253 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SKV9 A0A8C0SKV9_CANLF Solute carrier family 25 member 33 SLC25A33 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] pyrimidine nucleotide transmembrane transporter activity [GO:0015218] EAGGATSNSEKVCVGKILNH;VIRTRLREEGTKYKSF;VLKSILEKEG 3 13.5 0.99047 -0.51212 0 0 0 0 6.85237 0 0 0 0 0 9.6458 0 0 0 0 A0A8C0SKW5 A0A8C0SKW5_CANLF RB transcriptional corepressor like 1 RBL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DLMKDRHLDQLLLCAFYIM;DQLLLCAFYIMAKVYRS;EVVAYNKNINGDFEMTDC;IITEGTKLKIAPSSSITAE;YEEYVLTV 5 7.3 1.0004 -0.61897 0 0 7.57856 8.12825 0 0 0 0 0 0 0 4.38336 0 0 7.94052 A0A8C0SKX8 A0A8C0SKX8_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] TSFKRSRNTDEMVEL 1 3.6 0.98752 -0.22885 0 9.29627 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SKY1 A0A8C0SKY1_CANLF ATP binding cassette subfamily C member 4 ABCC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EVENMMISVERVMEY;EVQLKDAVEDLP;FGSLLKKENEEADQS;LFELCICQTLHE;LFWWLNPLFK;LTETAKQVYFKRNYPDITQN;QDVAYVLQ;RLEEDDMYSVLPED;YPEVKPNPLQDANL 9 9.4 1.0026 -1.1269 0 0 9.64378 0 4.58862 0 0 0 0 4.01872 0 7.26669 6.82528 10.0715 0 A0A8C0SKZ7 A0A8C0SKZ7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] WNAHGKQSTT 1 2.3 0.99942 -0.61146 0 0 0 0 0 0 0 0 0 0 0 3.86066 0 0 9.44186 A0A8C0SL00 A0A8C0SL00_CANLF Fibronectin type III domain containing 3B FNDC3B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSQFIRAKTRPLPPLPPR;GPVTSHGFSVKWDP;LVGRESEYKQVYK;RCLDTSQELSGA;SLGEWRRSPAGPAEVPM;VEGKSCPSEVL;YKQVYKGEEATFQI 7 7.9 0.98523 -0.25865 0 3.27526 0 0 0 0 0 11.6872 6.36077 0 0 11.3425 0 10.3088 0 A0A8C0SL34 A0A8C0SL34_CANLF "Carnitine O-palmitoyltransferase 1, muscle isoform (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (Carnitine palmitoyltransferase 1B)" Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] mitochondrial outer membrane [GO:0005741] acyltransferase activity [GO:0016746] TASPARLV 1 1 1.0041 -1.1044 0 0 10.4568 0 0 0 0 0 0 10.124 10.7673 2.41403 0 10.867 0 A0A8C0SL38 A0A8C0SL38_CANLF Vacuolar protein sorting 13 homolog B VPS13B Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] ASLVIKVR;CIEGWGNWRWSEPFSVD;CKHSGNPGPE;DEFPTSKYFCGK;DIVLSVNITSAECYTV;DLQLSLWGGDVVL;ERLSEQQYNRLVDYIT;GPVPGSPVRSSVGTAPPDTS;GSLEILGSPAS;ISVHTTQIVVS;ITEIDCAQDSKQSNLF;LDVLEQELKL;LSPSSAYP;NEIFQTTGVKSKNPLPTL;PEKSLQPM;PVKLRKLVIQ;RLSEQQYNRLVDYITKTSC;RSHKSPQLLHICIEGWGNWRWSEP;SEQQYNRLVDYITKTSCH;SGDIPGTVRSWYHGQTS;SIFQAKLPRTQKEKRKSP;TRIDMQYT;VLSVNITSAECYTVGELWDRAFMDI;VVSVSEDTQQQAFPITEIDC 24 7.2 0.99731 -3.5266 10.5986 13.2858 13.5565 11.0658 0 8.91358 0 12.0126 13.9972 10.4001 0 0 6.59559 12.657 0 A0A8C0SL55 A0A8C0SL55_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ESIPCPKTPAEKKC;FSLETSDGWTSQSSGE;INEKPEELDKRN;LEERPLSFCR;MICLAENFR;PSLTNEIKSTA;SECHQSPQ;SPVKISSDDSK;TDGDFTSQ;TPKKSKRKSKKRCEKS;VLALGEFSTLNSN;YLEGIHLNI 12 7.6 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.27482 A0A8C0SL77 A0A8C0SL77_CANLF Glutathione S-transferase (EC 2.5.1.18) GSTM3 Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364] QIMDFRIQLVQLCYSP;VGRKERGKMPFYLPGLRISAD;VLGYSRAPDYD 3 16 0.97526 0.045829 0 0 0 0 0 0 10.7971 0 10.3779 0 0 0 6.33953 0 0 A0A8C0SL92 A0A8C0SL92_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLVEGFSTLLAFIW 1 4.1 0.94465 0.082989 0 0 0 0 0 0 8.68534 0 0 0 0 0 0 0 0 A0A8C0SL95 A0A8C0SL95_CANLF Guanine nucleotide-binding protein-like 1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] GPAGDEEEEEEE;HQHYPQLHIVLFTSFPRDPRTPQD;PRTPQDPSSVLKKSRRRGR;RSFQEYLGK;SSCEEEGEEDRDADEEGEGDEDTP;WKHYFHQHYPQLHIVLFTSFPRDP 6 14.4 0.99641 -0.10081 0 0 0 0 0 6.2384 0 10.725 7.19869 8.92023 0 0 8.4945 0 6.40683 A0A8C0SLA3 A0A8C0SLA3_CANLF Peptidase C1A papain C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] cysteine-type peptidase activity [GO:0008234] CCCCCCAGPAQ;CCCCCCCCA;CCCCCCCCAGP;CCCCCCCCAGPA;CCCCCCCCAGPAQP;CCCCCCCCCAGPAQ;CCCCCCCCCAGPAQP;CCCCCCCCCAGPAQPR;CCCCCCCCCC;CCCCCCCCCCA;CCCCCCCCCCAGPAQPR;CCCCCCCCCCAGPAQPRATFTA;CCCCCCCCCCCAG;CCCCCCCCCCCAGP;CCCCCCCCCCCAGPAQ;CCCCCCCCCCCAGPAQP;CCCCCCCCCCCAGPAQPRA;CCCCCCCCCCCAGPAQPRATF;CCCCCCCCCCCC;CCCCCCCCCCCCA;CCCCCCCCCCCCAG;CCCCCCCCCCCCAGP;CCCCCCCCCCCCAGPA;CCCCCCCCCCCCAGPAQPR;CCCCCCCCCCCCAGPAQPRA;CCCCCCCCCCCCAGPAQPRATF;CCCCCCCCCCCCAGPAQPRATFT;LCCCCCCCCCC;LCCCCCCCCCCC;LCCCCCCCCCCCC;LCCCCCCCCCCCCAGP;LCCCCCCCCCCCCAGPA;LCCCCCCCCCCCCAGPAQ;LCCCCCCCCCCCCAGPAQPRATFTA;LLCCCCCCCCC;LLCCCCCCCCCCC;LLCCCCCCCCCCCCA;LLCCCCCCCCCCCCAGPAQ;LLCCCCCCCCCCCCAGPAQP;LWLLCCCCCCCCCCCC;LWLLCCCCCCCCCCCCAG;LWLLCCCCCCCCCCCCAGP;RLWLLCCCCCCCCCCC;RLWLLCCCCCCCCCCCCAG;SYNNYGCSGG;VVDAVSWQDYLGGIIQHH;WLLCCCCCCCCCC;WLLCCCCCCCCCCC;WLLCCCCCCCCCCCC 49 17.5 0.06 1.0033 10.0275 9.91745 6.68874 9.48643 9.82053 8.67913 7.9431 9.99379 10.6616 5.54853 9.78131 8.90337 10.003 9.61287 7.7322 A0A8C0SLB7 A0A8C0SLB7_CANLF Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] NQKATLFFPSIMKTGFKMQICWQGH;QELLTFIDAE 2 18 0.97496 0.035538 0 0 10.0489 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SLC6 A0A8C0SLC6_CANLF Coiled-coil domain-containing protein 43 Canis lupus familiaris (Dog) (Canis familiaris) AASKGGGGDG;GGGGDGGF 2 5.3 1.0029 -1.7158 0 0 0 0 0 0 0 0 0 0 5.70008 13.2822 0 0 0 A0A8C0SLD1 A0A8C0SLD1_CANLF Protein DBF4 homolog A DBF4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] IQTEGNKGGGIPVQL 1 2.4 0.93801 0.063413 0 0 0 0 0 0 0 0 0 0 0 0 8.61184 0 0 A0A8C0SLE1 A0A8C0SLE1_CANLF J domain-containing protein DNAJC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGYCLLIM 1 3.4 0.98962 -0.26592 0 0 0 0 0 0 0 10.1317 0 0 0 0 0 0 0 A0A8C0SLE9 A0A8C0SLE9_CANLF Cellular repressor of E1A stimulateds 2 CREG2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] EDPRCARL;LDSASTEDALPA;PASAHKEDAHLPPA;PAVADLMKNP 4 15.5 1.0029 -1.377 0 0 0 8.34824 0 0 0 0 0 0 7.35332 0 0 0 0 A0A8C0SLF1 A0A8C0SLF1_CANLF Neuronal PAS domain protein 2 Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]" GGGGGGGG;LNTNHSPSVSSRS;LRLLLSQPIQPMM;QGSGHSDGSQ;QPAQAQQQPQHFLQVQA;RGPPSCAPPSPHGAAGWQRAP;VISTQGPRPMRSSQ 7 8.2 1.0027 -0.73362 0 0 0 0 0 9.51347 0 6.51609 0 0 10.0909 0 6.33335 0 0 A0A8C0SLF3 A0A8C0SLF3_CANLF "Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)" CACNA1G Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] catalytic activity [GO:0003824]; nucleotide binding [GO:0000166] AAPGGGGGP;RGSFLYGTPTM;VGALATYPRFQ 3 4.8 0.98785 -0.48412 0 9.73295 0 8.96029 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SLF5 A0A8C0SLF5_CANLF Transducin beta like 1 X-linked TBL1X Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] histone deacetylase complex [GO:0000118] transcription corepressor activity [GO:0003714] GHWGLCEDMTLLCTYCSTR;VERGVCIHTLTKH;WGLCEDMTLL 3 5.8 1.0024 -0.76928 0 0 0 0 0 0 10.1411 0 9.64003 0 10.7917 0 0 0 0 A0A8C0SLF9 A0A8C0SLF9_CANLF Coiled-coil domain containing 71 like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAPFPARQVRAPR;ERPPSDSRVFTDPA;RRRRPRRPRRPRRPRALLRRPQPGG;TASLVHFTGGGAPEAP;VYGYPGRP 5 17 1.0015 -0.95271 10.4994 2.2664 0 0 0 8.52352 0 0 0 0 11.5602 0 0 8.47816 0 A0A8C0SLH7 A0A8C0SLH7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein tyrosine phosphatase activity [GO:0004725] ADSNCGFAEEYEDLKLV;DANSTESSSQQSTTPTDS;KQQADSNCGFAEEYEDLK;LILTTGNAGHPSPDV;LPYDISRVKL;MAVNEITEPS 6 5.9 1.0027 -1.1628 0 0 0 0 0 0 10.6476 0 0 0 0 10.3214 0 0 6.55464 A0A8C0SLI9 A0A8C0SLI9_CANLF Long-chain-fatty-acid--CoA ligase SLC27A1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] EFYGATECNCSIANMD;GYMYFRDRS;VLNLGNCTWQPE;YFRDRSGDTFR 4 6.8 0.94269 0.05044 0 0 0 0 0 0 0 0 5.68128 0 0 0 0 0 0 A0A8C0SLJ1 A0A8C0SLJ1_CANLF Adhesion G protein-coupled receptor F5 ADGRF5 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; neuron projection development [GO:0031175]; regulation of lipid metabolic process [GO:0019216]; synapse assembly [GO:0007416] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CLKGLPPK;DIWFIVAAAIHDHFYPLNETA;DPISVSEGQ;EPNIMVDPLEATVPCKGSHHFRCC;LDIFCHFTN;TDLETAFWKGYSTLPGF;TVKTVTREW;VLSKPMLSTWKVSQQQQ;WKSVTKNRT 9 9.2 0.99788 -3.3379 6.2677 8.18071 10.7193 0 0 7.14343 7.09075 10.39 0 0 0 8.43359 10.9775 0 8.26917 A0A8C0SLK3 A0A8C0SLK3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824] ANKLGNLEEMDAF;IGWFVSLVLSL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.4 0.98161 0.035491 0 9.08651 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SLK9 A0A8C0SLK9_CANLF sn-1-specific diacylglycerol lipase (EC 3.1.1.116) DAGLB Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] plasma membrane [GO:0005886] AIASDDLVF;DEVISHSPGPPQE;FGRRWAIASDDLVFPG;TGLQYRDFIHISFHD;TNLEDLKKRILRVIAHCNKPK;WAIASDDLVFP 6 10.1 0.9886 -0.34438 0 0 0 0 0 0 5.93048 0 0 10.1239 0 0 0 10.3228 4.15737 A0A8C0SLL2 A0A8C0SLL2_CANLF Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytosol [GO:0005829] metal ion binding [GO:0046872] AAEIFLKSGSL;ALKILLKIF;GDEKVCMDVFKKYISINEL;HQEDLFLKPWMNDFKFPGKHSFL;ITETNSESSS;KPDGGYMQVSENSSKLKKENLRSLA;LWPCDRLDVL;QEANNSIGKTMH;VARAPGREEVE 9 8.3 1.0017 -1.8053 6.6139 0 0 6.07707 0 0 5.58466 9.86028 8.33284 0 0 9.78367 0 0 0 A0A8C0SLM8 A0A8C0SLM8_CANLF SLIT and NTRK like family member 2 SLITRK2 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] AGVLEHIG;EGDPVAYYRNL;GAFSKLNKLKVLI;VGEIVCETPFRLHGK;VLSMNHNTDTPRSLTVS 5 7.6 1.0024 -1.1732 0 0 9.75965 8.74933 0 0 0 0 0 0 0 9.03056 6.74133 3.24327 0 A0A8C0SLN1 A0A8C0SLN1_CANLF Dymeclin DYM Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794] LLPYTSKLVKTLLYNF;VIRTIQYNMTRTRDKYL;YAQDLNVIEE 3 6.9 0.98309 -0.25182 0 0 0 0 0 0 0 0 0 0 0 0 0 9.99492 0 A0A8C0SLP6 A0A8C0SLP6_CANLF cAMP-dependent protein kinase (EC 2.7.11.11) PRKACB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] IVSGKVRFPSHF;LFNLFILFDQ 2 6 0.98796 -0.48676 0 0 0 0 0 0 0 0 0 0 0 0 15.1291 12.2867 0 A0A8C0SLP8 A0A8C0SLP8_CANLF Protein Wnt Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] ICDNIPGLVSRQRQLCQRYPDI;RECQHQFRHHRWNCT 2 9.4 0.94344 0.10076 0 0 8.92449 0 0 0 0 0 0 0 0 6.64731 0 0 8.07922 A0A8C0SLR6 A0A8C0SLR6_CANLF Small ribosomal subunit protein eS24 (40S ribosomal protein S24) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] KTSRKLQRMQKQNE;TVPIRTRKFMTNRLL 2 32.6 0.99006 -0.19641 0 0 0 0 0 0 0 0 0 0 0 0 9.21914 8.92508 0 A0A8C0SLR8 A0A8C0SLR8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EMC complex [GO:0072546] AALRRRREAAL;HGGAGAFG 2 6.7 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.70006 0 0 0 A0A8C0SLS3 A0A8C0SLS3_CANLF Gametotin GGN Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; gamete generation [GO:0007276] GDGGGGGG;GGGGGGGA;PTNGEQESPGP;SLGGGGGL 4 4 0.98141 0.035491 0 0 0 0 0 0 0 0 0 7.22226 0 0 0 0 0 A0A8C0SLT9 A0A8C0SLT9_CANLF MPN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EMC complex [GO:0072546] AALRRRREAAL;ENRWRCRDPHYDYCEDWPEAQRI;HENRWRCRDPHYDYCE 3 9.5 0.98779 -0.48536 0 0 0 9.06832 0 0 0 0 0 0 0 0 9.09299 0 13.47 A0A8C0SLU6 A0A8C0SLU6_CANLF DDB1 and CUL4 associated factor 1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] AEGEFFIHDAEI;AIVLRRLRELQLQE;DDDEDDDDTDDLDELD;DEDDDDTDDL;EDQEEEEQEEEDDDEDDDD;EEDDDEDDDDTDDLD;EEEDQEEEEQEEEDDDED;EEEDQEEEEQEEEDDDEDD;EEEQEEEDDDEDDDDTD;EEEQEEEDDDEDDDDTDD;EEQEEEDDDEDDDDTDD;EGEDGEDEDSDADEEV;EQEEEDDDEDDDD;EQEEEDDDEDDDDTDDLDEL;ESFRKAKQ;HGSGQDMV;HLASLLLHNKF;HVLLMYIFDSL;LNMDTVCRLYEV;LVNAYVMTSRE;QEEEDDDEDDDDT;QEEEDDDEDDDDTD;QEEEDDDEDDDDTDD;QEEEDDDEDDDDTDDLDEL;RQRLAEDEDEEEDQEEEEQEEEDD;SQSPAIKKQLDRHLPSPPTL;VGRQRLAE;VIENQGSM;YYLSYNQDAMERVCMHPH 29 12.3 0.99672 -4.5461 0 8.02492 8.24589 11.1232 10.0877 10.5501 10.6903 7.3285 8.85303 0 14.9521 5.53294 12.4669 6.83162 7.87603 A0A8C0SLV5 A0A8C0SLV5_CANLF Frizzled-2 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; non-canonical Wnt signaling pathway [GO:0035567] plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] KFGFQWPERLRCEH;PGGPGGGG;TPGGPGGGG 3 4.3 1.0016 -0.74327 0 8.94784 0 0 0 5.94762 0 0 0 0 0 0 0 0 0 A0A8C0SLW6 A0A8C0SLW6_CANLF Tripartite motif-containing protein 44 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DEDSEEDSEEDSEEDMEDEQ;DLESESDEDSESEEDS;DLESESDEDSESEEDSGT;DLESESDEDSESEEDSGTDEDSEE;DSEEDSEEDMEDEQDSD;DSEEDSEEDSEEDM;DSEEDSEEDSEEDMEDEQD;EEDSEEDSEEDMEDEQ;EEDSEEDSEEDMEDEQDSDAEDD;IELVERLKFKSSDPKVTRD;LICVLCPV;SEEDSEEDMEDEQDSDA 12 22.5 1.0019 -0.9598 6.86777 8.48949 0 8.11671 0 0 7.58654 8.80655 7.27296 4.66426 0 0 0 0 7.43979 A0A8C0SLW9 A0A8C0SLW9_CANLF EPM2A interacting protein 1 EPM2AIP1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978]; positive regulation of glycogen biosynthetic process [GO:0045725]; response to insulin [GO:0032868] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; nucleus [GO:0005634] identical protein binding [GO:0042802] DVLPDHVGVLDGVDLSP;GALCLVCRRLVVATR;INLTRHFSVGALMAAILE;VSIGATTVHFT;YSGFLHLE;YSGFLHLEL 6 11.5 1.0027 -1.3546 8.87477 10.3193 0 0 0 0 10.1161 0 0 0 0 9.71354 3.3584 3.82467 10.0473 A0A8C0SLX7 A0A8C0SLX7_CANLF Grid2 interacting protein GRID2IP Canis lupus familiaris (Dog) (Canis familiaris) CASPTAAPRPARCGPGLSLGRE;DLEPEPEPE;DYEEMSFHDDQG;ESVLPGSP;FLGYTAMTAEP;KKHRARFDEVV;LPETPNPKMMSAVYA;NPKMMSAVYAELESRLNSSFKGK;SETSHMSVKRLRWEQ;SRAPSPQP 10 10.2 1.0021 -1.4177 0 9.37702 7.84987 9.43471 10.3606 9.6382 11.0393 0 0 0 0 0 0 9.92148 9.4169 A0A8C0SM11 A0A8C0SM11_CANLF Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection morphogenesis [GO:0048812]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491] AGARSPAPRDLSP;AQEEEPVYIEMVGDVFRGG;KGGFGAGG;LHTPRPCSQPRDAPSQT;PKDKAVSYTMVYSAVKVTTHSVLP;VGGVTEDGSARRPP;VGSAGGCC;VPGCHRGAPLRAAPCFAP 8 12.3 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 3.34922 0 0 A0A8C0SM18 A0A8C0SM18_CANLF Coiled-coil domain containing 177 Canis lupus familiaris (Dog) (Canis familiaris) AERRAKLQQCRAERERI;GAEPEGSG;GSRYVLTSPRSLEA;KEKVERDEDCRRRELLQAIGRKLER;RGREEREEARRRQRQ;RRRQRQCERS;STAAAAAQ 7 12.4 1.003 -2.4658 0 8.76762 0 0 9.81785 0 0 0 0 9.40735 0 0 10.6113 0 10.8199 A0A8C0SM22 A0A8C0SM22_CANLF LON peptidase N-terminal domain and ring finger 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] GPAPGEGRRGLPRRRVRGGGGAP;LSDELSDRKRIYDEEMT;NTIDFAGHT;SSSGLGKLSAEGHTVNTID;VHQNLTSS;VHQNLTSSIQSRI 6 8.2 1.0026 -0.71462 0 10.2281 0 0 0 0 0 0 11.8927 0 0 0 0 0 0 A0A8C0SM27 A0A8C0SM27_CANLF ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) Canis lupus familiaris (Dog) (Canis familiaris) "D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]" intracellular membrane-bounded organelle [GO:0043231] ribose-5-phosphate isomerase activity [GO:0004751] IDGADEVDAD;VFTLNPQRAAEVDMPLQ 2 8.9 0.98238 -0.25134 6.05372 0 0 0 0 0 0 0 7.49681 0 0 0 0 0 0 A0A8C0SM56 A0A8C0SM56_CANLF Proline rich 5 like PRR5L Canis lupus familiaris (Dog) (Canis familiaris) FITDYFQNQLLAKG;GGGGGGGG;GGRGGGGG;LELRRRGRRRGRRRRRRRRRRR;LLAMATRMHPGLGEEPGGDD;LRRRGRRRGRRRRRRRRR;TDYFQNQLLAKG;VINVFKGGGLQSNELYALNE 8 15.4 0.99211 -0.032366 5.85287 0 0 8.03859 0 0 0 0 0 8.41172 0 0 5.13549 0 0 A0A8C0SM66 A0A8C0SM66_CANLF DnaJ heat shock protein family (Hsp40) member A3 DNAJA3 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457]; response to heat [GO:0009408] ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] EIFITFRVQ;ILAKPPVP 2 2.2 1.0035 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.19672 A0A8C0SM67 A0A8C0SM67_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MKKKKKKK;MNEKGEITTNT 4 5.5 1.0035 -1.1044 4.24382 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SM73 A0A8C0SM73_CANLF NFAT activating protein with ITAM motif 1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of cytokine production [GO:0001819]; regulation of B cell differentiation [GO:0045577] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] GVPTSTLIW 1 4.1 0.98224 -0.2497 0 0 0 0 0 12.4115 0 0 0 0 0 0 0 0 0 A0A8C0SM91 A0A8C0SM91_CANLF Major facilitator superfamily domain containing 2A MFSD2A Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate transport [GO:0008643] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] symporter activity [GO:0015293] AERPAQVKKEPKKKQQL;KFTLKLLVTIAPIVLILLGLL;LLVTIAPIVLILLGLLL;TLKLLVTIAPIVLILLGLLL 4 7.4 0.98298 0.046227 0 0 0 0 0 0 0 0 0 0 0 6.56336 0 0 0 A0A8C0SMA4 A0A8C0SMA4_CANLF Transcriptional repressor GATA binding 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270] DSGDLGKWQDKI;MRPAKHPNYSPPGSPIE;MSCHGDSG;QHLCTDKYDFTT;SCHGDSGP;SERGSPIEKY;SPLERRSEDHLTEGHQREIPLP;YSLLNPDSKMGEP 8 9.2 1.0036 -2.2465 6.64472 0 6.66846 14.7696 0 11.5954 0 9.07756 0 9.98527 0 6.75275 0 0 6.30005 A0A8C0SMA6 A0A8C0SMA6_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP1 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of DNA repair [GO:0006282] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] EDYKEKLPKGNGKRKSDTEFGNMK;EEEARGVVENYDDDEVSI;PSQKKSRVKINWLK;SKEHQSLEE;VGEDKYFCENCH;VGEDKYFCENCHHYT;VKVTEEKDFL 7 12.4 1.0018 -0.96192 0 5.33764 0 0 0 3.48078 14.7155 13.7408 9.78594 4.32912 4.9541 3.42385 3.38571 0 0 A0A8C0SMB6 A0A8C0SMB6_CANLF MAM domain containing 4 MAMDC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAGGWEDASVGRLQWR;EAAGATLRSPV;GEATCNFVCDC;LILVLLVLLGLVGRCWLQKKG;LVDLDGPGQQGAGVDDVTLKD;LVSVAEPSSPAVLS;VGSALLILVLLVLLGLVG;VLFETGVLGPG 8 8.5 0.88193 0.13097 0 5.81665 0 0 2.46616 4.14462 0 0 0 0 0 0 0 0 0 A0A8C0SMC2 A0A8C0SMC2_CANLF D-3-phosphoglycerate dehydrogenase LOC119863976 Canis lupus familiaris (Dog) (Canis familiaris) NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617] EIWPLCDFI;GASTKEAQSRCGEEI;ISSLLPAWKRG;SPAVIVGL 4 8.8 1.0029 -1.6275 0 0 0 5.29212 0 5.85112 0 0 9.01226 0 0 0 0 0 0 A0A8C0SMC4 A0A8C0SMC4_CANLF "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12)" DARS1 Canis lupus familiaris (Dog) (Canis familiaris) aspartyl-tRNA aminoacylation [GO:0006422] cytoplasm [GO:0005737] aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524] DTRLDNRVIDLRTST;LVLRQQQFNVQ;QSNSYDMF 3 7.3 0.98762 -0.36869 0 0 0 9.71162 0 13.1223 0 0 0 0 0 0 0 0 0 A0A8C0SMF1 A0A8C0SMF1_CANLF RNA binding motif protein 15B Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] RNA binding [GO:0003723] GGGGGGGG;SLDAAQAA 2 2.4 0.98471 -0.25882 0 0 0 9.42947 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SMF4 A0A8C0SMF4_CANLF Contactin-5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EEITESTATLSWSP;LVIAWEPVSEEFQNGE 2 2.9 0.99156 -0.18226 0 0 0 0 6.90677 0 0 8.49241 0 0 0 0 0 0 0 A0A8C0SMG4 A0A8C0SMG4_CANLF Chloride channel protein CLCN4 Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; synaptic vesicle [GO:0008021] voltage-gated chloride channel activity [GO:0005247] AYPNPYTRRST;DWIVFRNW;EQCCWTSNETT;FEDRDKCPLW;GVYTAMWQ 5 7 1.0028 -1.9062 0 0 0 0 0 0 7.0227 0 6.52366 9.3987 0 9.08039 0 0 9.36188 A0A8C0SMG9 A0A8C0SMG9_CANLF FAM212 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein serine/threonine kinase inhibitor activity [GO:0030291] RHGEGPAASCPKA 1 4.7 0.98871 -0.26425 0 0 0 0 9.99223 0 0 0 0 0 0 0 0 0 0 A0A8C0SMI1 A0A8C0SMI1_CANLF MYC associated zinc finger protein MAZ Canis lupus familiaris (Dog) (Canis familiaris) MKMPTMVPLSL;MLSSAYIS;VGSLSGAEGVPVSSQPL 3 8 0.97548 0.045413 13.7903 13.7249 13.8577 11.2363 0 0 13.7229 0 13.8265 13.6262 13.6196 13.6553 0 0 13.309 A0A8C0SMI2 A0A8C0SMI2_CANLF Carcinoembryonic antigen-related cell adhesion molecule 23 CAECAM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IMGGTGSPEFFHSV 1 2.7 0.9923 -0.14022 0 0 0 0 0 0 0 0 0 0 0 0 0 14.8527 0 A0A8C0SMJ6 A0A8C0SMJ6_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GAGVPKAPAGGGKGRSLAAAGS;GGGGGGGA;GGGGGGGG;GVPSASPVPGPA;HSAGGGGW;PPGPGGLF;QVTLYDPA;RPEAAAPIP;SSPGDPDYSSSSEQSC;TFAELQERLEGIDGSEGPPGPLG;VLQLWPPPT 11 6.2 1.003 -2.1091 12.0075 13.0526 11.3709 7.47849 8.01257 0 11.6008 0 12.577 0 8.41105 11.4334 11.6187 12.395 0 A0A8C0SMK2 A0A8C0SMK2_CANLF Zinc finger protein 672 ZNF672 Canis lupus familiaris (Dog) (Canis familiaris) HERAHGGDGCYRCLDCGERC;TKHRRTHTGERPYRCELCGRRFT 2 9.5 0.98927 -0.52207 17.7617 13.3676 0 0 0 13.0748 17.584 17.7317 0 0 17.3922 0 13.2275 17.6601 10.4946 A0A8C0SMK4 A0A8C0SMK4_CANLF DEK-C domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of double-strand break repair [GO:2000779] nucleus [GO:0005634] DNA binding [GO:0003677]; histone binding [GO:0042393] EEDEDDDEEEEEEEEEEKEKISS;EPLIKKLKKP;LIKKLKKP;PLIKKLKKPPTDEELKE;SEEEDEDDDEEEEEEEEEE;SSGPAADGDGAPAAPAADK 6 21.8 1.0029 -1.5245 0 8.62607 0 0 0 0 5.3168 0 0 0 6.95117 7.36554 6.16076 5.00293 0 A0A8C0SMM7 A0A8C0SMM7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) FVCNQKRPRIARGILKKKT 1 2.6 0.95436 0.049418 0 0 0 0 0 0 0 6.89045 0 0 0 0 0 0 0 A0A8C0SMN0 A0A8C0SMN0_CANLF Bone marrow stromal antigen 2 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607] membrane [GO:0016020] VEQECHNVT 1 5.1 1.0044 -0.80421 0 0 0 0 7.85985 0 0 0 0 0 0 0 0 0 0 A0A8C0SMN7 A0A8C0SMN7_CANLF Leucine rich repeat and fibronectin type III domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; synapse [GO:0045202] PPAQDRYEALREVASPAAAAV 1 2.7 0.95039 0.049623 0 9.37367 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SMP1 A0A8C0SMP1_CANLF ADAM metallopeptidase domain 22 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] AEGGGGGICIAETSDR;EECDCGTPAECVLEGA;EGGGGGICI;EPEENDTSQEDFHFHS;GGRCKTRDRQCKYIWGQ;GVSTNSASSSKKRSN;RDRQCKYIWGQKVMASDKY;VASFNFST 8 9.3 1.0025 -0.84185 9.24139 0 9.83569 0 0 8.81753 11.7959 0 0 6.14804 6.56797 7.3936 0 0 0 A0A8C0SMQ3 A0A8C0SMQ3_CANLF Enhancer of mRNA-decapping protein 4 EDC4 Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] P-body [GO:0000932] AASALHLLSP;ASPKLKRKGKK;ENEDCCEEG;FSSISEFLLTHPVL;HPSHSSCGHFSDLQ;PVLLSLIQQLASDLGTRTD;PVRVSQIK 7 5.8 0.93308 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 4.23028 0 0 A0A8C0SMQ4 A0A8C0SMQ4_CANLF Sterol regulatory element-binding protein cleavage-activating protein Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; SREBP signaling pathway [GO:0032933] endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139] sterol binding [GO:0032934] ERPEWYVGAPVAYIQQ;KGGPEEPG;LRLPKRLRVI;LVLDNAAIV;PGEPPEPG;PLPGTGPV;PPPVAPDH;RLPKRLRVI;VPLVLRGH 9 6.1 0.99696 -5.5379 4.07211 0 0 0 0 0 8.25465 9.1114 0 8.97186 10.1404 0 9.10003 10.8347 5.62425 A0A8C0SMQ9 A0A8C0SMQ9_CANLF "Pro-neuregulin-1, membrane-bound isoform" NRG1 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell myoblast differentiation [GO:0060379]; endocardial cell differentiation [GO:0060956]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4-ERBB4 signaling pathway [GO:0038138]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of secretion [GO:0051048]; nervous system development [GO:0007399]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein-containing complex assembly [GO:0031334]; ventricular trabecula myocardium morphogenesis [GO:0003222] extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; transcription coregulator activity [GO:0003712] PSCGRLKEDSRYIF;TAHHSTTVTQTP 2 3.6 0.98929 -0.19813 0 0 0 0 0 0 0 10.869 0 0 0 0 0 0 4.53748 A0A8C0SMR7 A0A8C0SMR7_CANLF WD repeat-containing protein 26 Canis lupus familiaris (Dog) (Canis familiaris) GAGGGGGG;GGGGGGGG;PAPFIDHQNIE;VTQGFYTIH 4 6.1 0.98833 -0.22723 5.10886 11.5226 9.46222 0 8.35984 0 0 0 0 0 10.2452 5.51049 4.20633 10.5924 11.6358 A0A8C0SMS5 A0A8C0SMS5_CANLF Dystrophin DMD Canis lupus familiaris (Dog) (Canis familiaris) muscle cell development [GO:0055001]; neuron development [GO:0048666]; regulation of muscle system process [GO:0090257]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane bounded cell projection [GO:0120025]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383] actin binding [GO:0003779]; zinc ion binding [GO:0008270] EEVLSWLLSAEDALQ;EITHVSQALSEVEEL;EKFGKQHIENLFSDLQ;FLSTSVQGPWE;HAFNIAKYQLGIEKLLDPE;KDLRQWQINVDVANDL;KMEKEPLGPD;KVHMITENINASW;LEDSKGVREL;LNLLLEYQK;LSWLLSAEDAL;QEALSRLDFQWERVN;QPGPAPGL;QPSLNSVNEGA;QRITDERKREEIKIKQQLL;SEDEETEVQE;SLTHMVVVVDES;VAIEDRIRQLHEAH 18 6.1 0.99708 -3.6077 0 11.3011 7.42551 9.98897 0 0 0 0 7.71253 0 0 11.1923 9.20136 10.6775 7.09698 A0A8C0SMT2 A0A8C0SMT2_CANLF Core shell protein Gag P30 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) virion assembly [GO:0019068] AAVSGQTLLRHL;IGPVSAPP;TVAWPQYRLNNQSQWPPEGTFDYQI 3 7.4 0.99036 -0.51113 9.0124 0 0 0 8.14843 0 0 0 0 0 0 0 0 0 6.66619 A0A8C0SMV1 A0A8C0SMV1_CANLF Ubiquitin thioesterase OTU (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] LGKTNQEYCDWIKRDDT 1 4.9 0.98401 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 9.4475 0 A0A8C0SMW9 A0A8C0SMW9_CANLF Olfactory receptor OR4S7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ENNVTEFI;LFGCTEIFILTVMAYDRYVAIC 2 8.9 0.99402 -0.12168 0 0 0 0 0 0 0 0 0 0 0 0 10.0364 0 10.0137 A0A8C0SMX4 A0A8C0SMX4_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FYIIGGVATLLFILVIIVFKEKPKH;GGWGRPRCT 2 4.8 1.0023 -0.76868 0 0 0 0 5.16511 0 9.11465 0 0 0 0 0 0 0 0 A0A8C0SMX8 A0A8C0SMX8_CANLF SET binding factor 1 SBF1 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AGGSGGGP;DPGFLRPQR;EGGLVQLSPATPATP;EQLYKNENPYPAVAMHK;LRYSFTYVPIL;PLVGEQVVVRSFP;QTHIRALY;RRTPVFYNYMYAPEDAEVLRPYSN;RSYPGLLI;SKRLPPIQKPKLLRPRLLP;SRCSVALLFRQLGITNVLSLF;TAESENRSYE;TESGVTSDHLKGL;TVPECVHIPPLPEP 14 10.2 0.99709 -4.0024 9.6137 9.46746 9.59427 0 0 0 10.1289 9.45518 9.79568 0 0 5.24546 10.0672 9.86079 10.9983 A0A8C0SMZ5 A0A8C0SMZ5_CANLF Protein phosphatase 1 regulatory subunit 35 C-terminal domain-containing protein PPP1R35 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; cytoplasm [GO:0005737] phosphatase binding [GO:0019902] GRGGGGVGE;LELAEGEEAVAVPGP 2 7.5 1.0035 -1.058 0 9.2832 0 0 0 0 0 0 0 9.54645 0 0 0 0 0 A0A8C0SMZ9 A0A8C0SMZ9_CANLF Trafficking protein particle complex subunit 11 TRAPPC11 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] EIVCKCHKDETVTI;FCANRRADRVPISFKVLPGDHE;HVIVENIPLHVN;IQKKTPLPP;VKSHKEFLN;VTYPNPDPLETQ;YNLVHLRAHE 7 8.1 1.0019 -1.8005 0 0 8.59518 0 0 0 8.67013 0 11.4162 0 0 0 0 0 0 A0A8C0SN05 A0A8C0SN05_CANLF [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) KDM6A Canis lupus familiaris (Dog) (Canis familiaris) heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; mesodermal cell differentiation [GO:0048333]; multicellular organism growth [GO:0035264]; neural tube closure [GO:0001843]; notochord morphogenesis [GO:0048570]; positive regulation of gene expression [GO:0010628]; respiratory system process [GO:0003016]; somite rostral/caudal axis specification [GO:0032525] histone methyltransferase complex [GO:0035097] chromatin DNA binding [GO:0031490]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ENWDPTGTKKIWHCESN;LYGLGLVYFHYNA;NTSMVPETSRHAGE;SLQNKTKLLPSIEE 4 4 1.0021 -0.66849 7.49474 5.49096 10.7697 0 10.2479 0 0 10.0428 0 0 0 0 0 8.38301 0 A0A8C0SN17 A0A8C0SN17_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DTITHHHTHPD;LFSADEMEE 2 5.2 0.9892 -0.21663 0 8.92763 0 0 0 0 0 0 0 0 0 0 0 3.44784 0 A0A8C0SN27 A0A8C0SN27_CANLF Palmitoyltransferase (EC 2.3.1.225) INTS15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] LILQGMVYSEY;QLVVLSDLYLETYIDH;QVHLTEKNL;RAMPKLLHYLFRTRNHTFIILH;RLILITFLNTPIA 5 11.3 1.0035 -0.83592 0 0 0 0 0 0 0 0 0 0 8.76215 9.80689 9.79159 0 0 A0A8C0SN64 A0A8C0SN64_CANLF CMP/dCMP-type deaminase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] CVSEQNEPGSKENGV;VSEQNEPGSKENGV 2 3.1 0.93843 0.071096 0 0 9.63074 7.66917 0 0 0 9.56824 5.294 0 0 12.1898 0 0 0 A0A8C0SN73 A0A8C0SN73_CANLF HEAT repeat containing 3 Canis lupus familiaris (Dog) (Canis familiaris) FIGFIEAP;LETLKTIG;NLSACGGFEVCDDMV 3 4.5 1.0024 -1.0001 0 0 10.6797 0 0 0 0 0 0 0 0 0 0 10.5556 0 A0A8C0SN82 A0A8C0SN82_CANLF Solute carrier family 2 member 9 SLC2A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hexose transmembrane transporter activity [GO:0015149] AELGACVAGTH;VAGTHPGACLRRWAPD;VEEVLAESRVQRN;VKLIGKVLGRKYTLLV 4 8 0.99161 -0.13702 0 0 0 10.074 0 0 6.77716 0 0 0 0 0 0 0 0 A0A8C0SNA6 A0A8C0SNA6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" RFAPDASRHSH;VLLSFYALH;YQRRQWMLKAI 3 6.4 0.98877 -0.26242 0 7.33503 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SNA7 A0A8C0SNA7_CANLF Prickle planar cell polarity protein 2 PRICKLE2 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CSSSSESDN;DDSGCALEEYAWIPP;EHMVTVMPLEMEK;ENMTPTEQ;HCFESLYAEYCDTCAQ;SNRLSADVDPLSL;STLGGRGQLHSRKRQKSKNCII;YCCHCFESLYAEYCDTCAQ 8 11 1.0029 -2.5419 0 10.6862 9.13676 0 0 7.14741 0 0 9.41284 6.74658 10.5304 10.0407 9.33787 9.54607 9.11762 A0A8C0SNB1 A0A8C0SNB1_CANLF TGF-beta family profile domain-containing protein LOC100855618 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] AAGWASGH;NVILRKHRN;TFFRASPGP 3 4.1 1.0033 -1.6105 9.0313 0 0 0 0 9.36183 0 11.2074 0 0 0 0 0 0 0 A0A8C0SNB6 A0A8C0SNB6_CANLF diphosphoinositol-polyphosphate diphosphatase (EC 3.6.1.52) Canis lupus familiaris (Dog) (Canis familiaris) pyrophosphatase activity [GO:0016462] SPHSTPAGR;YVYVLTVTEILE 2 5.5 0.99699 -0.58831 0 0 0 0 0 0 0 9.55861 0 0 0 0 0 0 0 A0A8C0SNC0 A0A8C0SNC0_CANLF D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor) Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] plasma membrane [GO:0005886]; synapse [GO:0045202] dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled receptor activity [GO:0004930] AGGERSVRPGPGGAAAR 1 2.4 0.99448 -0.11745 10.8725 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SNC5 A0A8C0SNC5_CANLF t-SNARE coiled-coil homology domain-containing protein STX8 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] endomembrane system [GO:0012505]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] FEEPEETRGLGFDEIRQQQQKIIQE;LVASFKNEGAEPDLIRSS 2 18.3 0.98914 -0.52467 0 0 0 0 0 0 10.504 0 0 9.98314 0 0 0 0 0 A0A8C0SNC9 A0A8C0SNC9_CANLF L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) Canis lupus familiaris (Dog) (Canis familiaris) lysine biosynthetic process via aminoadipic acid [GO:0019878] cytosol [GO:0005829] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] AAEPRRVAA;EPRRVAAGRALHPARGEGA;RNWALKESFIK 3 9.7 0.99293 -0.047516 0 0 0 0 7.88338 0 0 0 0 4.56334 0 0 0 0 8.27193 A0A8C0SNE2 A0A8C0SNE2_CANLF FMR1 neighbor Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VMAATPQPGWQAS 1 4.7 0.94128 0.059853 0 0 0 0 0 7.90165 0 0 0 0 0 0 0 0 0 A0A8C0SNE4 A0A8C0SNE4_CANLF PHD-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macromolecule biosynthetic process [GO:0010558] nucleus [GO:0005634] metal ion binding [GO:0046872] GPAKLVKNCFLPLREYFK;SGLLQRRKKWR;SLQVHTQHPLFEG 3 10.9 0.98445 -0.24262 0 0 9.89124 0 0 0 0 10.4108 0 0 0 0 0 0 0 A0A8C0SNI2 A0A8C0SNI2_CANLF LON peptidase N-terminal domain and ring finger 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] GPAPGEGRRGLPRRRVRGGGGAP;ISLKERLLAIRRILVII;LSDELSDRKRIYDEEMT;SLKERLLAIRRILVII;VHQNLTSS;VHQNLTSSIQSRI 6 7.5 0.92452 0.09546 0 0 7.36378 0 0 0 0 0 0 11.0808 0 0 0 9.00442 0 A0A8C0SNI6 A0A8C0SNI6_CANLF Ubiquitin thioesterase (EC 3.4.19.12) OTUB1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair [GO:2000780]; protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; ubiquitin binding [GO:0043130] PDGNCFRAFGF;YLVVYLRLL 2 7.2 0.99196 -0.20914 0 17.658 0 0 0 0 0 0 0 0 0 0 0 9.67828 0 A0A8C0SNJ6 A0A8C0SNJ6_CANLF Sushi domain-containing protein LOC100855476 Canis lupus familiaris (Dog) (Canis familiaris) AKESTVQSPV;ASDGPTTLTCQKNLTW;TYFLGDTI 3 6 0.98742 -0.3276 0 0 0 0 0 0 0 12.5553 11.2197 0 0 0 0 0 0 A0A8C0SNJ7 A0A8C0SNJ7_CANLF "60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60)" Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell activation [GO:0050870]; positive regulation of type II interferon production [GO:0032729]; protein import into mitochondrial intermembrane space [GO:0045041]; protein refolding [GO:0042026]; T cell activation [GO:0042110] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087] AHRKPLVIIA;FGDNRKNQLKDM;VSIIVGWKKVGRKGVITVKD 3 19.4 0.97305 0.048206 0 0 0 0 0 0 0 0 0 5.98543 0 0 0 0 0 A0A8C0SNK0 A0A8C0SNK0_CANLF Small ribosomal subunit protein eS31 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GTQIKKRKKKSYTTPKKNK;KKVKLAVLKYYKVDKN;TTPKKNKHKRK;TTPKKNKHKRKKVKLAVLK;VGVFMASHFDIQ 5 52.1 0.98957 -0.1982 0 0 0 0 0 0 0 0 0 0 0 0 6.94942 0 5.77041 A0A8C0SNL4 A0A8C0SNL4_CANLF Otopetrin 1 OTOP1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] proton channel activity [GO:0015252] EGQGAPPS 1 1.4 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 7.87952 0 0 0 A0A8C0SNM3 A0A8C0SNM3_CANLF MAGE domain-containing protein LOC102156856 Canis lupus familiaris (Dog) (Canis familiaris) EQPQGSFH;RLVFGLDVI;RSKSRGGPGN;SGSEGEEDADSSPCGGAS;VGSSGSEGEEDADS 5 11.7 1.0019 -1.2727 12.1146 0 8.06264 0 0 0 0 0 10.0243 0 0 0 0 0 0 A0A8C0SNN9 A0A8C0SNN9_CANLF Basophilic leukemia-expressed protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGA;GGGGGGGG;LQVAKVSP;NVSPAPEAPPRPGSPG;PPAPKPRKA;WGIPNLNKATPGS 6 9.2 1.0024 -1.1874 0 0 9.6747 8.14975 0 0 0 0 0 0 0 0 9.38924 0 9.90302 A0A8C0SNP4 A0A8C0SNP4_CANLF Rho-GAP domain-containing protein ARHGAP30 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] APSCCSSDSAGP;EDDTAGCGRQGPPG;EFEAERKPDLRKDVYL;EVFLSAYDDLS;GAVSMDGESG;GPGPPDEKLEASSAAG;PGPCAPGL;PSCCSSDSAGPRPDGQEENEE;RSIFNLGRSGHETKRKLPRG 9 10.4 1.0026 -1.1624 0 0 9.9506 0 6.6946 9.53277 6.60147 0 0 0 0 9.48925 0 8.53341 6.68328 A0A8C0SNR7 A0A8C0SNR7_CANLF LINE1 type transposase domain containing 1 L1TD1 Canis lupus familiaris (Dog) (Canis familiaris) EALVLEEEGEEEA;STFQCHSVVNTKYGV;TLQTDAQTSKETDLIQETEENF;TQENQEIGEDEQ;VLEEEGEEEASV 5 7.5 0.98676 -0.35628 0 0 7.94907 6.85873 0 0 0 0 12.265 0 6.89324 0 9.21395 9.71757 0 A0A8C0SNT3 A0A8C0SNT3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) HMIPSLDA 1 1.1 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.78581 0 0 9.83419 A0A8C0SNU5 A0A8C0SNU5_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] HPGFSDAYQDYEEYWRAY;ISGNMNQNQRL;NMNQNQRLDA;NPTECQESP;PYSLTFIELVEDYEHYINEG 5 7.3 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 4.71034 6.31917 0 0 0 0 A0A8C0SNV0 A0A8C0SNV0_CANLF Lactase LCT Canis lupus familiaris (Dog) (Canis familiaris) cellobiose catabolic process [GO:2000892]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733] external side of apical plasma membrane [GO:0098591] beta-glucosidase activity [GO:0008422]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803] LQDIGGWE;PAAGSHPC;SPMREEEVQFLGLTLGA;TADFPTKIRAFPF;VGHNLIKAHAEAWHLYNDVYRASQG;VISITISSDWAEPR;VLLSFSCWGLDW 7 5.1 1.0037 -1.1057 0 0 0 0 0 10.1558 0 16.2905 0 0 0 9.99718 9.04136 10.4345 0 A0A8C0SNV3 A0A8C0SNV3_CANLF Neurogenic mastermind-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607] transcription coactivator activity [GO:0003713] ESSDRERESTLQ;GTPAAYTPNQ;LPCSQPGTYSVTSGV;PSGSPQLRPPSAGPAFSMAPS;SGNNGGGG 5 5.9 1.003 -1.6274 0 0 0 11.4548 0 0 0 8.61228 0 0 0 12.0988 0 0 0 A0A8C0SNV6 A0A8C0SNV6_CANLF HECT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842] AVYEEFQRGFYK;LKKRKTSIDVDLKKARDT;LLLSNGQVHSCGDNGRGQL 3 5.1 0.97586 0.048313 0 0 0 0 0 0 5.48716 5.44221 0 0 0 0 0 0 0 A0A8C0SNX1 A0A8C0SNX1_CANLF PHD-type domain-containing protein TCF20 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AGLNSQLHYKRQMYQQQQ;DFEQSKSQA;EPEIKLKYAT;FPLPPLQNKTAKGS;QASSQQQQQVQQLRQQ;TVTAGKEPPGSMTSTTSQ 6 4.5 1.0025 -0.72701 9.20004 0 0 0 0 8.39124 0 0 8.89354 0 9.55758 9.30661 10.01 0 9.23785 A0A8C0SNZ2 A0A8C0SNZ2_CANLF EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) EIPR1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] TESLSSQWPRSR 1 2.8 0.98667 -0.23173 0 0 0 0 0 10.921 0 0 0 0 0 0 0 0 0 A0A8C0SNZ9 A0A8C0SNZ9_CANLF Synaptotagmin like 4 SYTL4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] membrane [GO:0016020] small GTPase binding [GO:0031267] AESPTGLTSHKGEL;GVRLEDLQHMCLELT;SLRRKPAVNKRETVGQ;VQEQQKEPSVPFDVP 4 9.7 0.99551 -0.092947 0 9.23197 8.80716 0 0 0 9.15596 0 0 0 0 0 9.23644 0 0 A0A8C0SP01 A0A8C0SP01_CANLF Methylcytosine dioxygenase TET (EC 1.14.11.80) Canis lupus familiaris (Dog) (Canis familiaris) 5-methylcytosine catabolic process [GO:0006211]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; epigenetic regulation of gene expression [GO:0040029]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromosome [GO:0005694]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] CKYARSKTPRKFRLA;EAGLPVPS;FGCSWSMYFNGCK;LPGTLPSAEAGLPVPST;NSVYSYHSYYAQPS;RLRSKPWSPCKF;VEQIVEKDE 7 4.7 1.0031 -2.3092 0 0 0 0 0 10 0 9.50414 0 9.57491 9.75047 0 8.71108 0 9.21379 A0A8C0SP10 A0A8C0SP10_CANLF Proteasomal ATPase associated factor 1 PAAF1 Canis lupus familiaris (Dog) (Canis familiaris) proteasome complex [GO:0000502] SITCLDISSGGGLGVS 1 4.3 0.96176 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0475 0 A0A8C0SP21 A0A8C0SP21_CANLF "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (Heat shock 70 kDa protein 9)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] LVLSARQPPGAPQP 1 2.1 0.93288 0.060809 0 0 0 0 0 0 0 0 0 0 4.30597 0 0 0 0 A0A8C0SP22 A0A8C0SP22_CANLF Transmembrane protein 65 Canis lupus familiaris (Dog) (Canis familiaris) cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779] membrane [GO:0016020]; mitochondrion [GO:0005739] CILGMFPL 1 3.3 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 8.93148 0 0 0 0 0 A0A8C0SP56 A0A8C0SP56_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DKDGKGGEDLDNLIRANP;KKKRQSWFPP;PTGNGMKSTSQGTTLR;QENISGKYIQ;TFLQDNSWIKKRPEEEKDENY;YSKVMAKWIQ 6 12.9 1.0018 -1.3176 0 0 0 0 0 0 0 0 10.1329 0 10.9767 8.57958 0 0 9.8469 A0A8C0SP58 A0A8C0SP58_CANLF Nudix hydrolase domain-containing protein TRPM2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] calcium channel activity [GO:0005262] DIGAILLFAAGLSCRLIPGLLY;DPVGNALEPLAGIT;ESWALPGGSREPG;FIKRVVLKIPAKRHKQLKTKLEKN;HIFTVSKTLGPKIIIVKRM;LEKNEEAALLSWEIYLKEN;LFIKRVVLKIPAKRHKQL;LVCEELRQLLYDP;SVFFREMFETLPESSVVEWTKKIQD;VESSKLSDAGKVVCE;VQWQGVELQQ 11 11.7 1.003 -0.85148 0 0 9.06905 8.80287 5.41149 10.5716 6.76553 10.9695 0 12.444 0 0 0 5.44377 11.0403 A0A8C0SP61 A0A8C0SP61_CANLF Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; presynaptic membrane [GO:0042734] DEGSYHVDESRN;GFSCDCSM;GLPPELRAAAL;LPKLVHAKEGFQG 4 2.9 1.0033 -1.6552 0 0 0 0 0 0 0 0 8.56704 0 0 0 0 0 4.38688 A0A8C0SP65 A0A8C0SP65_CANLF Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Canis lupus familiaris (Dog) (Canis familiaris) "cytoplasm [GO:0005737]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] DGVDSGYMEDSEESSSE;LGDDEQEEEEEEEEEEDLETDGHCA;QELLTFIDAE;SAQLPILADMLLYYC;VKRQNPKSK 5 9.1 1.0012 -0.74478 11.8096 0 8.83153 0 0 10.1573 0 0 0 0 0 0 0 0 6.62825 A0A8C0SP70 A0A8C0SP70_CANLF DOCKER domain-containing protein DOCK4 Canis lupus familiaris (Dog) (Canis familiaris) cell chemotaxis [GO:0060326]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] KEHLHLAIIQNFDRG;PGAVGQLQQRHLLPEP;SDRPLREFLTYPM;VDGKKIGC 4 7.6 0.98961 -0.21448 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.95108 A0A8C0SPA9 A0A8C0SPA9_CANLF SEC7 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DGDNDSINSTSNSN;ELKTNEDHVSQVQKVEKLI;LFENQYYPNGIRLTS;PTGPTCTATHRCPRPMPATQATQA;SCRSTPSLERQ;THRCPRPMPATQ;VEKLIVGKKPVLS 7 7.4 0.94199 0.059561 0 0 0 0 2.58289 0 0 0 0 0 0 0 0 0 0 A0A8C0SPB8 A0A8C0SPB8_CANLF Photoreceptor cilium actin regulator PCARE Canis lupus familiaris (Dog) (Canis familiaris) AGDAGGSALSRSSSSEES;ARWTQSPNEGLYQLTRDPKGKDMEG;SHPRPRSSPGGPASPFQP;TAKVQPTAWGGAG 4 5.8 0.98956 -0.52939 0 8.56948 0 0 0 0 10.0897 0 0 0 0 0 0 0 11.1426 A0A8C0SPC2 A0A8C0SPC2_CANLF Regulating synaptic membrane exocytosis 1 RIMS1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] membrane [GO:0016020]; synapse [GO:0045202] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] EPKAQEPLRKQS;EQDSELQPSLDRARSASTNCLRP;ESSQQAVGPEQKQVSSRSR;ESVSEKGDLDYYWLD;GKPLPGATNEEV;KEQVRKIGEEARR;LSSMVIGWYKLFP;PRIQIQHASPE;RGKHPARSRS;VGAGGKKR 10 8.5 1.0038 -0.81252 11.2844 9.25512 10.6945 0 9.02287 0 8.83153 7.54759 0 0 0 0 0 7.79818 8.12799 A0A8C0SPD4 A0A8C0SPD4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;GACLWPRARSWRPGI;MDAFLESHKL;MNEKGEITTNT;MRDPWVAQRFGACLWP 5 7.1 0.96175 0.049233 0 0 0 0 0 0 0 10.775 0 0 0 0 0 0 0 A0A8C0SPD6 A0A8C0SPD6_CANLF Mediator complex subunit 6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020] transcription coactivator activity [GO:0003713] IPFSLKSPIIYFIIIF 1 3.6 0.962 0.049233 0 0 0 0 0 0 0 0 6.51437 0 0 0 0 0 0 A0A8C0SPG2 A0A8C0SPG2_CANLF Neurobeachin Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] ANRTSVMFNFP;HLISAAKHRDHVT;HSFYKETPATF;IAECGPEPIPYPDP;IILCKALKILTKKILVILIIQ;ITDPVLREAMEAQI;KALKILTKKILVILII;KILTKKILVILIIQ;KKILVILIIQ;KTFRSQAIVNQNAE;KTPLESVPGNLSPI;LCKALKILTKKILVILI;LCKALKILTKKILVILIIQ;LKILTKKILVILI;LKILTKKILVILII;PVFPWVLTNYESEEL;QLHDFWRLDYWEDDLRRRRRFVRN;SGSSSSSSSSSFVNGATS;SVNLDSITDPVLREAME;TDLLFALETDVHVW;VGGENGALVEVES 21 8.9 0.98432 -0.23832 0 0 0 7.35067 0 4.66084 0 5.66661 0 0 0 0 8.13725 7.54388 0 A0A8C0SPG7 A0A8C0SPG7_CANLF Neurobeachin Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] ANRTSVMFNFP;HLISAAKHRDHVT;HSFYKETPATF;IAECGPEPIPYPDP;KAMEAQIQNFGQTPSQL;KTFRSQAIVNQNAE;KTPLESVPGNLSPI;PVFPWVLTNYESEEL;QLHDFWRLDYWEDDLRRRRRFVRN;SGSSSSSSSSSFVNGATS;TDLLFALETDVHVW;VGGENGALVEVES;VINPADSSGITPKGLD 13 7.8 0.95117 0.057349 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1685 0 A0A8C0SPI4 A0A8C0SPI4_CANLF FAD-binding FR-type domain-containing protein NOX1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] oxidoreductase activity [GO:0016491] KWILAPGV;LVLMVTSAMEFIRRSYFEVFWYT;NFERYSRSR;PSCHMRKLISTTIP;SGISSQMYQTYRFCFESTLA 5 13.2 1.0016 -1.4663 10.2301 10.6164 0 0 0 8.50251 0 0 0 12.4521 0 0 0 0 0 A0A8C0SPI5 A0A8C0SPI5_CANLF Alkaline ceramidase (EC 3.5.1.-) Canis lupus familiaris (Dog) (Canis familiaris) ceramide metabolic process [GO:0006672]; phytosphingosine biosynthetic process [GO:0071602]; sphingosine biosynthetic process [GO:0046512] membrane [GO:0016020] phytoceramidase activity [GO:0070774] EAAEAAACAMAPAAD;IYSCCIFVYCM 2 6.7 0.93539 0.098029 0 10.9965 0 0 0 0 0 0 0 0 0 11.4813 11.1181 0 8.58545 A0A8C0SPL3 A0A8C0SPL3_CANLF Rho-GAP domain-containing protein ARHGAP6 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274] ELERARLQEVAFYQ 1 3.1 0.9369 0.060951 7.67864 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SPL5 A0A8C0SPL5_CANLF Carbohydrate sulfotransferase (EC 2.8.2.-) CHST10 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] GDGGGGAH;VLIVLNGAFPS 2 3.4 1.0018 -1.2887 0 0 0 0 0 0 11.2541 0 0 0 9.00868 0 0 0 0 A0A8C0SPL7 A0A8C0SPL7_CANLF Lipocalin 10 LCN10 Canis lupus familiaris (Dog) (Canis familiaris) small molecule binding [GO:0036094] APGPSWPRLQD;GSEGGGGLPRAVYR;QLRVVLAFSRSQ 3 14 0.85915 0.1468 0 0 0 0 0 0 5.93819 10.8724 0 0 0 0 6.02782 0 0 A0A8C0SPN1 A0A8C0SPN1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;CRWLLISPRVKKKKKKKKKKKK;ETIPILLKLFRKI;ISPRVKKKKKKKKKK;ISPRVKKKKKKKKKKK;ISPRVKKKKKKKKKKKK;KKKKKKKK;KKKKKKKKKKK;KKKKKKKKKKKK;KKKKKKKKKKKKK;KKKKKKKKKKKKKRE;KKKKKKKKKKKKREK;KKKKKKKKKKKKREKTQ;KKKKKKKKKKREK;LISPRVKKKKKKKKKK;LISPRVKKKKKKKKKKK;LISPRVKKKKKKKKKKKK;LISPRVKKKKKKKKKKKKK;LISPRVKKKKKKKKKKKKKR;LLISPRVKKKKKK;LLISPRVKKKKKKKK;LLISPRVKKKKKKKKKK;MDAFLESHKL;MNEKGEITTNT;PRVKKKKKKKKKKKK;PRVKKKKKKKKKKKKK;PRVKKKKKKKKKKKKKR;RVKKKKKKKKKKK;RVKKKKKKKKKKKK;RVKKKKKKKKKKKKKREK;SPRVKKKKKKKKK;SPRVKKKKKKKKKKKKKR;SPRVKKKKKKKKKKKKKRE;SPRVKKKKKKKKKKKKKREKTQINK;TIAPKRIRYLRINLTKEVKDLYPKN;VKKKKKKKKK;VKKKKKKKKKKK;VKKKKKKKKKKKKK;VKKKKKKKKKKKKKR;VKKKKKKKKKKKKKRE;VKKKKKKKKKKKKKREK;VKKKKKKKKKKKKKREKTQINKIMN;WLLISPRVKKKKKKKKKKK 43 10.9 0.93832 0.063825 9.68736 9.6536 8.60444 8.03304 7.4941 8.30355 9.11666 8.23424 9.01987 5.87708 7.19889 8.12422 7.40054 4.84278 10.1495 A0A8C0SPP4 A0A8C0SPP4_CANLF "Fatty acid-binding protein, liver (L-FABP) (Liver-type fatty acid-binding protein)" FABP1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908] cytoplasm [GO:0005737] fatty acid binding [GO:0005504] VEDVGDQAQVLSGPHGQAG 1 9.7 0.98249 -0.25137 0 0 0 0 0 0 0 0 0 9.44448 9.82416 0 0 0 0 A0A8C0SPP7 A0A8C0SPP7_CANLF TOX high mobility group box family member 4 TOX4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] chromatin DNA binding [GO:0031490] GKKQKAPKKRKKK;LDHSIGTQ 2 3.4 1.0045 -1.0448 0 0 0 0 6.05441 11.0687 0 0 10.6738 0 0 0 0 0 10.3078 A0A8C0SPQ1 A0A8C0SPQ1_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AAGAAGLRIGYCPQ;EEVFLTLLQGSKKPS;ETVVSCALRLLHLQKLEDVL;EYLLLPAAKPRL;FLPYIVLLVLR;GELRSSIHI;GVSVVMLSYLL;HCTASWLQ;ILYSMRTDLVKNP;IVNELTALQNVDRFT;LDVPDVPD;LSAALTCLPVIWCWNHTASG;NDSSSTSVKFLNIFATSPKEKDVNS;QAQSLVST;SGAGGESG;SRLLFHMNSSEDLL;TYSGGTRRKLSTA;VEFLTSVKSHL;VEKEQIRVL;VISGLYEFGFLK;VLCNLSKSYGSFRRTT;VLNSTKELLMMEKKLHPLEDEQIDY;VLNVTIWMLTFLQ;VLPRAVTRCCLSWA;VLSKSLNFSQLFHSDWP 25 7.1 0.99667 -4.7461 0 10.7796 10.2923 15.6621 15.6983 15.8589 12.7328 10.338 14.8826 0 8.28401 11.8906 13.8995 13.9204 13.8857 A0A8C0SPS0 A0A8C0SPS0_CANLF GST C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]" aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; nucleus [GO:0005634] CCPGPAPASSSCRK;VSPASSRPAPY 2 10.1 0.98631 -0.42651 0 0 0 0 0 0 11.1431 0 0 0 0 0 0 0 0 A0A8C0SPS6 A0A8C0SPS6_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DLDDDVIL;EEDCWLDHPYFQSLNQQSR;GVQRRPRRRR;GVQRRPRRRRQR;KIEKRMFFLENKRRHCRSYDRRALL;PGAPCQECSRCSLW;QECSRCSLW;TSELEKVL;VNYDFAPVHMPLEHNL 9 9.9 1.0039 -1.6829 0 3.37796 10.4309 0 0 0 0 10.4628 10.3982 0 8.9021 3.77695 8.73968 0 9.84889 A0A8C0SPU1 A0A8C0SPU1_CANLF Gamma-aminobutyric acid type A receptor subunit theta GABRQ Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] GVSMYVSS;IDIYMVVCFL;ISEMTMDY;LSSLSSLSEL;LTTTAACSLDLQK;SLPDDIRVESG;SRRNQRRRRRARRVMARYRYREVML;TISLREDQISI;TTVVSWISFWMN;VGVSMYVS 10 15.4 0.99904 -3.1915 0 0 9.98812 0 0 7.80838 7.37773 10.5611 0 0 0 8.47804 0 10.4609 0 A0A8C0SPV7 A0A8C0SPV7_CANLF Coagulation factor XII (EC 3.4.21.38) (Hageman factor) F12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] CQREKCFEPQLL;KEIWHRLEPAGVAKCECRGPDVHCK 2 6.1 0.99213 -0.5419 0 0 0 0 0 0 0 0 0 0 9.54859 0 12.8194 0 0 A0A8C0SPW6 A0A8C0SPW6_CANLF SEC7 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DGDNDSINSTSNSN;ELKTNEDHVSQVQKVEKLI;IGEFLGNRQKQFNRDVLDQRY;LFENQYYPNGIRLTS;PTGPTCTATHRCPRPMPATQATQA;SCRSTPSLERQ;THRCPRPMPATQ 7 8.8 0.99433 -0.56145 8.34988 0 0 0 0 7.00708 7.56415 9.48804 0 0 0 9.47178 0 4.851 0 A0A8C0SPZ7 A0A8C0SPZ7_CANLF L-lactate dehydrogenase B chain Canis lupus familiaris (Dog) (Canis familiaris) lactate metabolic process [GO:0006089]; pyruvate metabolic process [GO:0006090] mitochondrial inner membrane [GO:0005743] L-lactate dehydrogenase activity [GO:0004459] QIKLTTIKKKIL 1 6.2 0.94495 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.06497 A0A8C0SPZ8 A0A8C0SPZ8_CANLF Transmembrane protein 115 TMEM115 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" Golgi apparatus [GO:0005794]; membrane [GO:0016020] LLGLLLLLRLATL;PSMDDDEE;VVAGRLLEPLWG 3 9.4 1.002 -1.2749 0 0 0 0 4.79379 0 14.7278 14.6376 14.1273 0 0 0 0 0 6.26048 A0A8C0SQ12 A0A8C0SQ12_CANLF PDZ domain-containing protein LNX1 Canis lupus familiaris (Dog) (Canis familiaris) KKINRALSVLRRTKSGSA;LHLLRQPCQVLRL;VAGGASHR;VLPWLSPANYIDNVGNLHFLYSE 4 9.8 1.0034 -1.6406 0 0 0 0 0 0 0 11.8847 0 0 8.82642 0 0 0 6.93723 A0A8C0SQ41 A0A8C0SQ41_CANLF N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Canis lupus familiaris (Dog) (Canis familiaris) DPASVPHGAVYYPMMSD;GQSDHGRYHEEYIYPSE;GTAYGGSSQIHGAM;HYPQTAGSIMSNEHFHP;QLHVENYPVYAEPP;VYVPQMQQQQLHVENYP 6 16.6 0.97678 0.046227 0 6.08211 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SQ52 A0A8C0SQ52_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] small molecule binding [GO:0036094] FSGLWYVVS;TSPELRPSSSRGSNPRAD 2 10.9 0.99296 -0.28353 0 0 0 0 7.51987 0 0 0 0 0 4.05398 0 0 0 0 A0A8C0SQ54 A0A8C0SQ54_CANLF DAZ interacting zinc finger protein 1 DZIP1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cell projection [GO:0042995]; centriole [GO:0005814]; cytoplasm [GO:0005737] metal ion binding [GO:0046872] EIPKAKQLPPRSRPLIRQRP;EMQKTKEEEFLKLFDRWKEEEKEK;LPVQSSKSNKSGFG;PAAAAMACAPHR;QQLMIEAKASYYQCHFCDKAF;TSKNSALEYESKW;VESARHEQE 7 13.8 1.0028 -1.1448 0 3.1354 0 0 0 0 7.94691 0 0 6.99107 8.74265 0 9.74838 0 8.95096 A0A8C0SQ88 A0A8C0SQ88_CANLF Lymphocyte cytosolic protein 1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] FKLFDETDPGPNPPFSILCL;LVIFQLYEKIKVPVD 2 5.1 0.93141 0.10694 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.81698 A0A8C0SQA3 A0A8C0SQA3_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated potassium channel activity [GO:0005249] DETTTLIGLLKTARLLRLVRVARK;HYSPFKAVWDWL;PGKSSADVRALTYC 3 5.5 0.93304 0.060832 10.3931 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SQA5 A0A8C0SQA5_CANLF Dystrophin DMD Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; muscle cell development [GO:0055001] cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886]; Z disc [GO:0030018] actin filament binding [GO:0051015] EEVLSWLLSAEDALQ;FSDLKEKVNVGYVL;HAFNIAKYQLGIEKLLDPE;KMEKEPLGPD;LSWLLSAEDAL;SEDEETEVQE;SLTHMVVVVDES 7 10.3 0.94441 0.061154 7.16772 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SQA7 A0A8C0SQA7_CANLF NADH-ubiquinone oxidoreductase chain 1 (NADH dehydrogenase subunit 1) Canis lupus familiaris (Dog) (Canis familiaris) aerobic respiration [GO:0009060] mitochondrial respiratory chain complex I [GO:0005747] NADH dehydrogenase activity [GO:0003954] AEYANIIIIY 1 14.5 0.99194 -0.27072 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.90899 A0A8C0SQC5 A0A8C0SQC5_CANLF ENT domain-containing protein EMSY Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] EALLAQTGFGHSNWKQ;EDPQSYTDSSSSSTESSQSSQ;ESELVAEYITTERT;GVPTTGQFMRIQNV;IVSGTTTKITTIP;RLVPQTAF;SIEGRRLV;SLVGAPTQILAQFP;VVVAGMANSTPQQQKCRESCSSPS 9 10 1.004 -1.0737 0 10.7575 0 8.19982 0 0 0 0 7.11322 9.07932 0 0 0 0 8.05967 A0A8C0SQC8 A0A8C0SQC8_CANLF Iduronate 2-sulfatase IDS Canis lupus familiaris (Dog) (Canis familiaris) iduronate-2-sulfatase activity [GO:0004423] PFSSVQELMEP;SSLAPPSPFPW;VELLSLSP;VGKVFHPG 4 7.5 1.003 -2.3563 0 9.36411 7.25776 0 0 0 0 0 7.80484 12.7269 0 0 0 0 0 A0A8C0SQF2 A0A8C0SQF2_CANLF Uncharacterized protein SLC35B3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HVGGSGAR;QETLNKGEET;YARRSFYSREAL 3 7.5 1.002 -0.6716 9.33047 0 0 0 0 0 0 0 0 0 0 9.38793 0 0 0 A0A8C0SQF5 A0A8C0SQF5_CANLF Hydroxysteroid dehydrogenase-like protein 2 HSDL2 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome [GO:0005777] oxidoreductase activity [GO:0016491] CSPQTIAK;ETFRIVKDSL 2 2.9 0.98875 -0.52331 8.97272 0 10.9067 9.66622 0 10.0195 0 0 0 0 0 0 0 0 0 A0A8C0SQG6 A0A8C0SQG6_CANLF "Tsukushi, small leucine rich proteoglycan" Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] GAGRAGGF;SSGPGTWVEPSSWKGLEKNT 2 4.6 1.0005 -0.6328 0 0 0 0 0 0 0 0 0 0 0 10.0366 0 9.92394 8.33396 A0A8C0SQI3 A0A8C0SQI3_CANLF Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Oviductal glycoprotein) (Oviductin) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; single fertilization [GO:0007338] transport vesicle [GO:0030133] chitin binding [GO:0008061] GENLTSEVNTDPLLGYV;LDPFLCTHLI;RIRSDQDSRRHS;VTLGEMTMISMQL 4 8.9 0.98517 -0.43724 0 0 0 0 0 0 0 9.20185 0 0 0 0 9.38812 0 0 A0A8C0SQK3 A0A8C0SQK3_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of complement activation, classical pathway [GO:0045959]; T cell mediated immunity [GO:0002456]" extracellular space [GO:0005615]; plasma membrane [GO:0005886] LSCNCTFP;NFKWSKPDEFCK;VPNAQPIL 3 13 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 6.74672 0 0 A0A8C0SQK8 A0A8C0SQK8_CANLF VWFA domain-containing protein CACNA2D2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] calcium channel activity [GO:0005262] AENFQKAHRWQDNIKEEDILYYD;ANVRNKKVF;CGPSSHCEMDCEVN;FIENRRQD;IYKDNRNLFEVQENE;KAQPVSCFTHL;NSFYTRKESYD;YVDEVVRNYTW 8 8.9 1.0026 -1.1431 9.86983 0 0 7.72007 9.84131 9.6195 10.6029 0 8.4407 10.8216 0 8.99628 9.49727 0 7.75989 A0A8C0SQL3 A0A8C0SQL3_CANLF InaD-like protein PATJ Canis lupus familiaris (Dog) (Canis familiaris) AIVIHEVY;ATDGRMRIGDELLE;DELLEINN;IHEVYEEGAAARDG;IVIHEVYEEGAAARDGRLWA;MAVAPFPVPSSSPSSLEAVSQ;SIAGGKGS;VGTKRATDPSLKSSGMDMGP 8 13.7 0.96127 0.048782 0 0 0 0 8.02015 0 0 0 0 0 0 0 0 0 0 A0A8C0SQL4 A0A8C0SQL4_CANLF LIM and senescent cell antigen-like-containing domain protein LIMS1 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] IVNSNGELYHE;PLELKKRLKKLA;YEKFPLELKKRLKK 3 7 0.94602 0.05044 4.78309 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SQN4 A0A8C0SQN4_CANLF MARVEL domain-containing protein SYNPR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; synaptic vesicle [GO:0008021] ATCGGYSG;SSPLLSSLPLSL 2 3.6 0.98917 -0.22636 0 9.81572 0 8.46046 0 0 0 0 0 10.3136 10.4519 0 0 10.6418 0 A0A8C0SQP3 A0A8C0SQP3_CANLF Histamine N-methyltransferase (EC 2.1.1.8) Canis lupus familiaris (Dog) (Canis familiaris) N-methyltransferase activity [GO:0008170] TDGNENGELLCDFL;TQYPGIHINNEV 2 9.1 0.99125 -0.13507 0 0 0 0 0 0 0 0 0 0 0 8.90944 0 9.38083 0 A0A8C0SQP5 A0A8C0SQP5_CANLF ETS domain-containing protein ETV5 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" PAPRGRCNG;VSGKRLQWSLLPMDT 2 3.9 1.0018 -0.75031 8.88911 0 0 0 0 0 0 0 0 4.15607 0 0 0 0 9.37764 A0A8C0SQQ1 A0A8C0SQQ1_CANLF MAGE domain-containing protein LOC480926 Canis lupus familiaris (Dog) (Canis familiaris) ATTSIPEPEGAA;ESRRQQWHQWRGQH;NVEDMDEGSDEVGE;SETYNVEDMDEGSDEVGEEEMVEGN;VGEEEMVEGNDYE 5 7.2 0.9366 0.060924 0 0 0 0 0 0 0 0 0 0 0 0 0 6.62294 0 A0A8C0SQR3 A0A8C0SQR3_CANLF Transmembrane protein 179 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ELQDINLELNVDN;FSFVVVVPLS;LFTEGMWLSANLTVQE 3 16.8 0.98782 -0.47086 10.1165 7.42509 0 0 0 0 0 0 0 0 0 0 0 6.51756 0 A0A8C0SQR4 A0A8C0SQR4_CANLF "Protein preY, mitochondrial" PYURF Canis lupus familiaris (Dog) (Canis familiaris) AAGAGCQT;GERLKRRKRLKRPGAGRAAG;RLRGERLKRRKRLKRPGA 3 13 1.0015 -1.315 0 0 0 0 0 0 9.5446 0 0 0 0 0 0 0 0 A0A8C0SQT9 A0A8C0SQT9_CANLF Leptin EGFL7 Canis lupus familiaris (Dog) (Canis familiaris) TLGSCSCC;TSGLRRQQWGPGPS 2 7.6 0.98532 -0.24686 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.60726 A0A8C0SQU1 A0A8C0SQU1_CANLF Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (Sorting protein-related receptor containing LDLR class A repeats) Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; transport vesicle membrane [GO:0030658] AAGGGGGG;ACDGDMDCQDGSDEDPVNC;CDFDNDCGDMSDE;CDGDMDCQDGSDE;CDGDMDCQDGSDEDPVN;CDGHQDCQDGQDEANCP;CDGMDDCGDYSDEANCENPTEAPNC;CGDNSDESHCEMHQCRSDEY;DFDNDCGDMSD;DGENDCGDWSDEKDCGD;DGMDDCGDYS;DLEDDCGDNSDES;ECDFGFKMSEDFFLE;FILYAMRRSIHRYD;FSLSLENVLYYSPGG;GASAFQAARST;INEYYIADASED;LPAAVFRV;NSDESHCEMH;NWKRCDGHQDCQDGQDEAN;NYTFTVQARCLFGS;PSGDLMCECPRGYQQENHTCIKEEN;QYRCSNGNCINSIWWCDFDNDCGD;SSGMCIRSSWVCD;TAFANSHYSSRLGSAIFSSGD;VCDEFSFQCQNGV;VIAQFYHSPAD;WVCDGDNDCRDWSD 28 13.5 1.0025 -1.3734 9.14366 7.34038 5.62848 0 6.01223 8.10423 10.1288 1.46514 5.65567 9.94171 9.67227 10.1913 9.35328 10.378 9.85348 A0A8C0SQV7 A0A8C0SQV7_CANLF Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] PCSLHCPHPGP 1 1.9 0.98607 -0.24596 0 0 0 0 0 0 0 0 0 0 0 0 0 9.22896 0 A0A8C0SQW8 A0A8C0SQW8_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AAGAAGLRIGYCPQ;EEVFLTLLQGSKKPS;EYLLLPAAKPRL;FLPYIVLLVLR;GELRSSIHI;GVSVVMLSYLL;HCTASWLQ;ILYSMRTDLVKNP;ISQTTLEQVFIKF;IVNELTALQNVDRFT;LDVPDVPD;LSAALTCLPVIWCWNHTASG;NDSSSTSVKFLNIFATSPKEKDVNS;QAQSLVST;SGAGGESG;SRLLFHMNSSEDLL;TYSGGTRRKLSTA;VEFLTSVKSHL;VEKEQIRVL;VISGLYEFGFLK;VLCNLSKSYGSFRRTT;VLNSTKELLMMEKKLHPLEDEQIDY;VLNVTIWMLTFLQ;VLSKSLNFSQLFHSDWP 24 6.8 0.93881 0.059747 0 0 0 0 0 0 0 0 0 6.60733 0 0 0 0 0 A0A8C0SQX7 A0A8C0SQX7_CANLF Transforming growth factor beta-3 proprotein TGFB3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell junction organization [GO:0045216]; detection of hypoxia [GO:0070483]; face morphogenesis [GO:0060325]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein secretion [GO:0050714]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; response to progesterone [GO:0032570]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; transforming growth factor beta binding [GO:0050431]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] QDLGWKWV;VLALYNSTRELLEEMQGER 2 5.9 0.99204 -0.20716 0 6.92315 0 0 0 0 0 0 0 0 0 0 0 0 8.99144 A0A8C0SR01 A0A8C0SR01_CANLF Mitochondrial carrier 2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] mitochondrial outer membrane [GO:0005741] CWCMLQKEGNMSRGNSLFFRKVPF 1 7.9 0.99239 -0.291 0 0 0 0 0 0 0 0 10.2451 0 0 0 0 0 0 A0A8C0SR13 A0A8C0SR13_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGVRFILMGEKTIY;GKESILCTSEGVWTPTV;ISGKEAPYFYNDS;LIFLIGVTLCT;MGEKTIYCTA;PTCESDFPLECPP;QNGKKLFDLLGEKS;SDLSEFAIGTSWEY;SIHCMPSGTWSPSPPRCEEA;SVLWNNKFPVCEQIRCE 10 9.2 1.0033 -0.87707 7.4224 10.5239 0 4.47229 0 3.13414 10.6902 0 13.2136 0 0 2.72681 0 8.91501 4.44261 A0A8C0SR17 A0A8C0SR17_CANLF Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (Sorting protein-related receptor containing LDLR class A repeats) Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; transport vesicle membrane [GO:0030658] AAGGGGGG;ACDGDMDCQDGSDEDPVNC;CDFDNDCGDMSDE;CDGDMDCQDGSDE;CDGDMDCQDGSDEDPVN;CDGHQDCQDGQDEANCP;CDGMDDCGDYSDEANCENPTEAPNC;DFDNDCGDMSD;DFDNDCGDMSDERNCQMHQ;DGENDCGDWSDEKDCGD;DGMDDCGDYS;ECDFGFKMSEDFFLE;FILYAMRRSIHRYD;FSLSLENVLYYSPGG;GASAFQAARST;INEYYIADASED;LPAAVFRV;NWKRCDGHQDCQDGQDEAN;NYTFTVQARCLFGS;PSGDLMCECPRGYQQENHTCIKEEN;QYRCSNGNCINSIWWCDFDNDCGD;SSGMCIRSSWVCD;TAFANSHYSSRLGSAIFSSGD;VCDEFSFQCQNGV;VIAQFYHSPAD;WVCDGDNDCRDWSD 26 13 0.95558 0.04941 0 0 0 5.25482 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SR23 A0A8C0SR23_CANLF Translocon-associated protein subunit gamma (Signal sequence receptor subunit gamma) Canis lupus familiaris (Dog) (Canis familiaris) SRP-dependent cotranslational protein targeting to membrane [GO:0006614] endoplasmic reticulum membrane [GO:0005789] EATTFSIFYSWSPNSG;IEELQPNGELYF 2 21.4 0.99164 -0.54815 0 0 0 0 0 0 0 9.69036 0 0 0 0 0 0 0 A0A8C0SR64 A0A8C0SR64_CANLF Tubulin--tyrosine ligase-like protein 5 TTLL5 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] cilium [GO:0005929] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] AAFMPITSSTDPA;EEEEEDGV;ETEQMAEKKLKKKLEEE;LHFALQQLEQQKL;NQAKYTPSLTV;WNNKGESCCKIDTQ 6 5.8 0.99167 0.010616 0 0 6.2476 0 0 9.00206 0 0 0 13.8374 0 4.87814 3.93433 0 0 A0A8C0SR67 A0A8C0SR67_CANLF Sestrin 3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TORC1 signaling [GO:1904262]; regulation of response to reactive oxygen species [GO:1901031] cytoplasm [GO:0005737]; nucleus [GO:0005634] AHYHALASFVF;PEISNGFRLIS;RHYIAIMKLV;VVSGDTFHSFPHSDFEDDMI 4 14.8 0.98912 -0.20435 0 0 0 0 6.37459 0 9.47023 0 9.34554 0 0 0 0 1.27471 12.5596 A0A8C0SR68 A0A8C0SR68_CANLF Small-subunit processome Utp12 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] IVEWNTQT;KDEDVDEENEEEEEDAEEKDEENGE;LVYEEESSEEESD;PAPPQTEEVESKRKLGENEVSI;QVTASEKTKEMTC 5 11.9 0.99714 -0.59435 11.955 0 0 0 8.12536 0 0 0 0 0 0 6.95942 5.23833 0 0 A0A8C0SRA5 A0A8C0SRA5_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231] GAGGGGGG;LTEKNFEDTIAEGLTFIKFYAPWCG;PEPAAEPPRAPERKQ;PPPFSSPLLPLP;SPPHPSFPLPFPPSPL 5 10.1 0.85828 0.18484 0 0 0 0 9.09167 0 0 0 0 0 0 0 10.6778 0 0 A0A8C0SRA6 A0A8C0SRA6_CANLF UPF3B regulator of nonsense mediated mRNA decay UPF3B Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleic acid binding [GO:0003676] DEKPRRPEEESGR;DTSLYPHMYARAYINF;RERERLKR;VVIRRLPPTL 4 10 1.002 -1.2904 10.6049 0 0 0 0 0 7.96653 0 0 0 0 0 0 0 4.18031 A0A8C0SRA9 A0A8C0SRA9_CANLF histone acetyltransferase (EC 2.3.1.48) CREBBP Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654] DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] LSTLPTAA;NCYNTKSHAHKMVKW;NPQYREMLRRQLLQQQQQQQQQQQQ;TRWHCTVCEDYDLCINCY 4 2.8 0.98734 -0.32772 0 0 9.76172 0 0 0 0 12.3031 0 0 0 17.3479 0 13.5529 12.0666 A0A8C0SRB3 A0A8C0SRB3_CANLF AAA+ ATPase domain-containing protein NVL Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ADLMALCRE;ELTMILAPVRSPE;KMGLTDEKSNHKQ;VLLAGPPG 4 5.2 0.99506 -0.15834 8.35663 0 0 0 0 0 0 0 0 0 0 0 0 9.8794 0 A0A8C0SRB7 A0A8C0SRB7_CANLF Myosin binding protein C1 MYBPC1 Canis lupus familiaris (Dog) (Canis familiaris) IEDVWGENVA;LDPAYQVDKG;STELFVREPPIL;TIKWFKGK;VGSRALERKDSEWS;YQGVNTPGQP 6 5.4 1.0025 -1.3691 10.5871 0 0 0 0 0 0 0 10.0214 8.33065 0 0 0 0 8.04346 A0A8C0SRE6 A0A8C0SRE6_CANLF Zinc finger protein 674 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" AENGCTNRCWRREQT;HQRTHTGEKPYECCECTKAFSQK;RQRLPKYYSW;VFMQKANLVVHQRTH 4 7.4 0.98767 -0.22951 0 0 0 0 8.29228 0 0 0 0 0 0 0 0 0 0 A0A8C0SRH3 A0A8C0SRH3_CANLF Diencephalon/mesencephalon homeobox 1 DMBX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" ASESAPEDQPEREE;PEARVQVWFKN;YSLHAMNSLSAMYNL 3 10.7 0.99721 -0.58755 0 8.85334 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SRH8 A0A8C0SRH8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSTLSAHIIVV 1 3.8 0.99127 -0.14526 0 0 16.8188 16.8202 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SRH9 A0A8C0SRH9_CANLF "ETS proto-oncogene 1, transcription factor" ETS1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" GLEHCGSG 1 1.7 1.0039 -1.1044 0 0 0 9.69159 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SRI5 A0A8C0SRI5_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GQYPRVSVCQTLTAINE;ILNGHHTGTSWG;LVGTESLWNNSVPVC 3 7.9 0.98645 -0.32227 0 0 0 0 11.7515 0 11.3147 0 0 0 0 0 0 0 0 A0A8C0SRI9 A0A8C0SRI9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RMND5A Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] FQPFALNHQKDIQVL;VEHFFRQG 2 6.2 0.98652 -0.45604 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.13152 A0A8C0SRM3 A0A8C0SRM3_CANLF Signaling lymphocytic activation molecule family member 1 SLAMF1 Canis lupus familiaris (Dog) (Canis familiaris) lymphocyte activation [GO:0046649] cell surface [GO:0009986]; membrane [GO:0016020] signaling receptor activity [GO:0038023] IVGVILIFEVVLLLLRRRGKTNH;NPVSNRSWSFNPWSKCRPE;QHFCLQLKLYE;VPRQWRLYAGLFL 4 19.9 0.99402 -0.16187 6.26765 0 0 0 0 0 9.0492 0 9.60633 0 0 0 0 0 0 A0A8C0SRM4 A0A8C0SRM4_CANLF SLAIN motif family member 1 Canis lupus familiaris (Dog) (Canis familiaris) CASTGGGSG;FSSIRECRRSPSTQYFPSNNYQQQ;GAGGGGGG;GGGGGGGG;GPEPGGAGTPPGGAPAPPSPPPT;GTFCLPSPAPSLLCSLAQ;NRTNGDKLRRSMPNLARMPS;SPAFPGTFCLPS 8 18.6 1.0026 -1.1889 5.74833 0 0 0 0 0 8.80184 6.08649 9.47687 0 9.22887 0 0 0 10.1147 A0A8C0SRN4 A0A8C0SRN4_CANLF Forkhead box I3 FOXI3 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDLMKMVRP;KMFDNGNFRRKRKRR 2 5.6 0.98446 -0.24269 0 0 0 0 7.49354 0 0 0 0 0 0 0 0 0 0 A0A8C0SRQ9 A0A8C0SRQ9_CANLF Vasoactive intestinal peptide receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] vasoactive intestinal polypeptide receptor activity [GO:0004999] DACGYHDAEDD;IVNFVLFVSIIRILLQ;TPAWTKLHCTRNYI 3 9.1 0.85736 0.15211 4.18515 0 0 0 6.14602 5.03073 0 0 0 0 0 0 0 0 0 A0A8C0SRT0 A0A8C0SRT0_CANLF EGF-like domain-containing protein EFEMP2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] HRDFSCNDIDEC;LATRLCQDIDECESG;PGSLLLWALLLLL;SCVDVNECDMGAPCEQRCFN 4 13.6 1.0038 -0.8241 8.89354 0 8.54323 0 0 0 0 3.51197 0 0 0 0 0 0 0 A0A8C0SRT7 A0A8C0SRT7_CANLF Lysine rich coiled-coil 1 Canis lupus familiaris (Dog) (Canis familiaris) HYQEGRRRRSREEGREG 1 8.8 0.97657 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.78607 A0A8C0SRX7 A0A8C0SRX7_CANLF Calcium-transporting ATPase (EC 7.2.2.10) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] LQHLLARDLVPGDIVSL;QEYRSEKSL;VIVKKLPIV 3 3.7 1.0011 -0.9347 0 0 0 0 0 3.72585 0 0 0 0 0 0 8.66981 0 0 A0A8C0SS00 A0A8C0SS00_CANLF Solute carrier family 46 member 2 SLC46A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LTGVVTST;LVVKRHVQIK;SFGAGAGA;VGLLLKVLL;VGLTPLLSAYALGWLSDRRHR 5 11.6 0.99964 -0.61146 0 3.65718 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SS02 A0A8C0SS02_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKG Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509] CRKEGFHFQAENGV;DQLQKYSEYSSKKI;GVGQARRAERASPL 3 5.4 0.99 -0.19856 0 0 0 0 0 0 0 0 0 0 0 7.74403 11.4465 0 0 A0A8C0SS12 A0A8C0SS12_CANLF Myosin X MYO10 Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; membrane [GO:0016020]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DESSEEDPYMNDTV;EDLQRMKERQE;HCIAESWMNFSLFLQEMS;HYDYDRDDYEDGA;RAFLLRRRFLHLRKAAI;RERERARREAELRTQQEE;TFTPCERLEKRRTSFLEGTL;VEFAFMFEQAHEAVIR 8 7.1 0.97271 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 8.04133 0 0 A0A8C0SS47 A0A8C0SS47_CANLF Nucleoside phosphorylase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleoside metabolic process [GO:0009116]; nucleotide catabolic process [GO:0009166] cytoplasm [GO:0005737] uridine phosphorylase activity [GO:0004850] GRDLGVPVGESRGGGSG;LGLDHPGA;NRLDGDQVPP;VLAAMCSACG 4 7.7 0.97667 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 6.81044 0 0 A0A8C0SS60 A0A8C0SS60_CANLF Olfactory receptor OR51A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALNTCVSHICAVLVYYVPMISL;IVYSMKTKEIRN 2 10.4 0.94128 0.10207 0 5.93005 0 10.0656 0 0 0 6.76527 8.83295 0 0 0 0 0 0 A0A8C0SS65 A0A8C0SS65_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCEPYCCSSTPCQ;CCTPICCKPDCCQ;QPSPCRPS 3 13.5 0.91713 0.11912 0 5.96079 0 0 5.97108 0 0 0 0 0 0 0 0 0 0 A0A8C0SS75 A0A8C0SS75_CANLF Protein SET LOC403555 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDDDDDDEGEEGE;DEDDDDDD;DEDDDDDDDDDDDEG;DEDDDDDDDDDDDEGEEGEEDED;DEGEDEDDDDDDDDDD;DEGEDEDDDDDDDDDDDEGEEG;DTDEEEEEEEEEEEEDVDDDDDD;DVDDDDDDEGLEDIDERDEG;EDDDDDDD;EDDDDDDDDDDD;EDEDDDDDD;EDEDDDDDDDDDDDE;EDEDDDDDDDDDDDEGE;EDEDDDDDDDDDDDEGEEGE;GEDEDDDDDDDDDDDEG;IDERDEGEDEDDDDDDDDDDDEGE;PDTDEEEEEEEEEEEEDVDDDDDD;VPDTDEEEEEEEEEEEE 18 20.5 0.68302 0.30116 5.42408 4.68353 6.42111 7.65206 6.9697 9.61198 8.39968 6.91648 8.32314 0 5.08929 0 0 5.63958 0 A0A8C0SSB0 A0A8C0SSB0_CANLF "Myotubularin-related protein 2 (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)" MTMR2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] early endosome membrane [GO:0031901] ENGWKLYDSLLEYRRQGIPNESW;ESEDAYQNAEL;EYKEIFPENGWKL;HNIHVMRESL;QMTRQFPTAFE;RQFPTAFEFNEYF;SYGLETVCKDIRN 7 10.6 1.0014 -0.91526 9.86763 0 0 7.67786 0 11.4615 7.895 0 0 0 3.08616 0 0 0 10.9349 A0A8C0SSB8 A0A8C0SSB8_CANLF Adhesion G protein-coupled receptor L4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AAYDSYGNV;CAFWNYSPDTMNGSW;CHLDNACIA;CQENVSADCH;GGRKGPEEAASPGRAGP;GVEACYCNMGFSGN;GVIYNKGF;MGFSGNGVTICEDIDECSESAA;RTPQDAQVW 9 11.5 0.97823 0.047709 0 8.34523 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SSD0 A0A8C0SSD0_CANLF Gamma-crystallin S (Beta-crystallin S) (Gamma-S-crystallin) CRYGS Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of eye lens [GO:0005212] HYDCDCDCADF;PNFAGYMYIL 2 12.1 0.99675 -0.57597 8.16992 0 0 0 0 4.65992 0 0 0 0 0 0 0 0 0 A0A8C0SSD7 A0A8C0SSD7_CANLF BRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EEEEDPMERPREEEV;EPHSTIPTDQPLC;EVTQETVFL;MPQPIEPTAPDL;SVAEASHLVTDRVR;VLTTPEFQPSVPTD 6 6.6 0.95152 0.053874 0 5.44834 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SSD9 A0A8C0SSD9_CANLF C2H2-type domain-containing protein ZNF496 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLPGPRAEQEVSQ;RHRSSAHGEDRARPFQ;VGSPGPQA 3 4.9 0.9952 -0.15718 0 9.981 0 0 0 0 0 0 0 0 0 10.5193 0 0 0 A0A8C0SSE0 A0A8C0SSE0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;DIYRTLHPNSTEYIFF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.6 0.963 0.049233 0 0 0 0 0 0 0 4.99494 0 0 0 0 0 0 0 A0A8C0SSH8 A0A8C0SSH8_CANLF Dual specificity phosphatase 6 DUSP6 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of apoptotic process [GO:0043065]; regulation of heart growth [GO:0060420] cytosol [GO:0005829] MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine/threonine phosphatase activity [GO:0008330] GFGGCCGV;GGGGFGGC;GISRSVTV;LPVLGLGGLRISSDSSSDIESDLDR;RGGGGFGG 5 11.6 0.9976 -3.5435 12.0804 0 9.35403 6.51164 0 0 12.1473 0 0 0 8.79669 0 12.082 0 0 A0A8C0SSI0 A0A8C0SSI0_CANLF Endonuclease domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] DLHLRDPAP;IFDLHLRDP;LSSMTSEGS 3 4.3 1.0012 -0.74472 0 0 0 0 0 0 0 0 0 0 0 0 0 10.047 0 A0A8C0SSI5 A0A8C0SSI5_CANLF "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (Complex I-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I [GO:0005747] NADH dehydrogenase (ubiquinone) activity [GO:0008137] ESTVSVYKAANWYEREIWDM;GVIPVLTFLRDHT;KSLADLTAVDIPTRQNRFEIVY;PPPGHARR;QTRTTSTSRF 5 15.2 1.003 -0.73233 9.8584 0 0 0 0 0 0 0 0 0 10.0422 0 0 9.50902 8.11009 A0A8C0SSJ3 A0A8C0SSJ3_CANLF "TATA-box binding protein associated factor, RNA polymerase I subunit A" TAF1A Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase I [GO:0006360] RNA polymerase I transcription regulator complex [GO:0000120] APREKLISVLKILYQI;DDQVIKKKIKRIKKSVKK;DQVIKKKIKRIKKSVKKYSI;KKIKRIKKSVKK;KKIKRIKKSVKKYSI;SEELVRSKTEDEQ;VIKKKIKRIKKSV;VIKKKIKRIKKSVK;VIKKKIKRIKKSVKK;VIKKKIKRIKKSVKKYSI 10 12.1 0.73066 0.24508 6.56503 4.58532 8.49773 4.56181 0 0 5.09525 4.86007 0 0 3.91705 10.7814 5.29359 5.66684 7.164 A0A8C0SSJ6 A0A8C0SSJ6_CANLF RAR related orphan receptor C Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] EVQKQLQRQQQQ;PLGSSPDLPEA;STEIESPEGL;VVYSCTRQQ 4 8.5 1.0035 -1.0641 0 0 0 0 0 0 0 8.32921 0 0 0 10.0037 0 9.21296 0 A0A8C0SSL8 A0A8C0SSL8_CANLF HSF-type DNA-binding domain-containing protein LOC111094819 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] YRDEGRATAQDGSRGG 1 5.8 0.9846 -0.25757 0 10.0323 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SSM1 A0A8C0SSM1_CANLF RALBP1 associated Eps domain containing 2 REPS2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] ECFNPTTCHRCPRLCE;PELSYIWEL;RQPLVQPEGPS;SNSLKARPRSRSYSSTSIEE 4 8.2 0.99058 -0.51583 0 0 0 0 0 0 6.76871 0 0 0 0 0 7.78549 0 0 A0A8C0SSM7 A0A8C0SSM7_CANLF A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding domain-containing protein AKAP12 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein kinase A signaling [GO:0010739]; regulation of protein kinase C signaling [GO:0090036] membrane [GO:0016020] calmodulin binding [GO:0005516]; protein kinase A binding [GO:0051018] AENDLSKLQTESS;DLQTQAQPLT;EDELEASEKKKEQEP;EPLPLTAAVVEEKVLGEA;EVTVTDVGQR;GSSSPEQAGSPTEGEGV;KPLPEGQDAIDDTVV;PEDCDGAG;TEKTEEQRAEVEEVVEPLPSEKVAE;TSVSWEAL 10 8.1 0.99904 -3.2287 9.96204 9.00436 5.32308 0 9.56323 0 0 0 12.0954 0 8.58079 0 9.29542 15.8043 9.2213 A0A8C0SSM8 A0A8C0SSM8_CANLF SCA7 domain-containing protein ATXN7 Canis lupus familiaris (Dog) (Canis familiaris) AADFAPGAG;ARQQQQQQQQPPSQPQ;ESSGNSTNCHNASSSTS;GPGAASTS;GRGYYVFDSRWNRLRCA;PIDPPPVHESPHPP;PLDRLIGKKR 7 8.5 1.0035 -0.80421 0 0 0 0 0 0 0 0 9.30957 0 0 0 0 0 0 A0A8C0SSN1 A0A8C0SSN1_CANLF Reticulon RTN3 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] AIVKRDEREIEEIFI;DIISQLSKTEVIN;GSSCAEGL;TPTASLDLE;VFMWLMTYVGA;VHINRALKLIIRLFLVE;YVLEHTEV 7 8 1.002 -1.8355 11.825 0 0 3.42626 0 1.88561 8.58282 0 0 4.29895 11.6758 0 10.4687 0 0 A0A8C0SSN2 A0A8C0SSN2_CANLF "Signal peptide, CUB domain and EGF like domain containing 3" SCUBE3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] AATGVHCSCPVGFML;DECAEGNGGCQQ;DSKCHDAATGVHC;RDGRLYASENHQEILKDKKLIKA;VTYDEDYEQLV;YKLLINERNCQD 6 8.3 1.0016 -0.95371 0 6.46527 0 0 0 0 9.01221 0 8.63365 0 0 0 0 0 12.0119 A0A8C0SSR6 A0A8C0SSR6_CANLF DH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AAVQLPDGFNLLCPTPPPP;CLHISIAGS;LVSPDTPPTP;PSLEHRDSPRNRGP;SETLTLLSFLRSDL;TSPSTVSCPRAPLSPAGLGQGHT;VGTTRALR 7 4.7 0.99195 -0.55014 0 0 8.50649 0 0 0 7.30706 12.4603 0 0 0 0 8.4453 10.2937 0 A0A8C0SSS3 A0A8C0SSS3_CANLF Sushi domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IVSYACDPGYLLV 1 3.9 0.94115 0.05986 0 0 0 9.1073 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SSV3 A0A8C0SSV3_CANLF ATP binding cassette subfamily C member 11 ABCC11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] FSGFFAKITRKA;GVGLCFALFFTECL;IWDVLEKTFLSM;KAEDFISEFKRLTD;LLIKKIVKIHSHLSEI;LPVEVLLIKKIVKI;PEDTRDSLLPE;QAEVVESGRSFFSV;TPFMIQGVRRRLN;VEVLLIKKIVKI;VLHCCSLNHDLEI;VLLIKKIVKI;VLYVQALKD 13 9.6 1.0036 -1.0543 9.36822 10.1538 6.68636 11.3227 0 6.89336 12.7784 7.37278 0 12.0368 4.85235 12.2524 11.9214 9.61235 11.6228 A0A8C0SSV9 A0A8C0SSV9_CANLF Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked nuclear protein) Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; negative regulation of macromolecule biosynthetic process [GO:0010558] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] ADSTMVDVRVMKKR;EDKEDDEEEEEEEED;EVPQDKDGYKSSG;FMWDCCCES;GVGNSNEG;KGRKKIRKILK;KKKKTKGKK;KKRDTPMLPK;KYVESDDEKPLDETVNED;LEQLLQQNKKKIKV;NEGGRGKAGAKLFQDFQ;PNKLPKSKQSEIVDQNSDS;QQIDMRGMY;QSLSFRVVDQQQVERHFTMN;SENDITMQ;SNSEEDKEDDEE;SSTSGSDYDI 17 8.6 0.99723 -3.9908 10.1845 0 11.4703 8.43471 10.6466 0 0 11.8335 0 4.09204 5.10949 8.51428 4.48646 0 10.159 A0A8C0SSW5 A0A8C0SSW5_CANLF CD44 antigen (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (Phagocytic glycoprotein I) CD44 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576]; microvillus [GO:0005902]; plasma membrane [GO:0005886] hyaluronic acid binding [GO:0005540] DINPSNTDDDVSSGSSSERSTS;DTYCFNASAPPEEDCTSV;EDSSWTYFF;PSADPNTHLV;TTHGSESAGHSSGSQE;VIHFLSEDHD;YSISRTEAADLCK 7 13.2 1.0025 -1.4018 0 0 0 0 11.9934 0 0 14.1126 14.1315 0 0 6.28027 9.48919 6.75248 14.1839 A0A8C0SSX3 A0A8C0SSX3_CANLF Interleukin 34 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein phosphorylation [GO:0001934] extracellular space [GO:0005615] macrophage colony-stimulating factor receptor binding [GO:0005157] LEGHPSWKYL 1 4.3 0.9901 -0.26579 9.06188 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SSY2 A0A8C0SSY2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CCTPQSSCQPSCCSSSPCQEDSC;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;EASPCCQQSSCQPSC;PCCQQSSCQPSCCNSSPCQEGCC;PSCCNSSPCQEGCCVSVCC;QPSCCNSSPCQEGCC;QPSPCRPS;SCGSCSPCQEGCCM;SDVRMALTSREDT;SPCQEGCCMSVCC 12 45.1 0.99243 -0.28673 0 0 0 0 0 0 0 0 0 0 10.2457 0 0 0 0 A0A8C0SSY6 A0A8C0SSY6_CANLF m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (Scavenger mRNA-decapping enzyme DcpS) Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290] cytoplasm [GO:0005737] hydrolase activity [GO:0016787] AGPRLVLAHVGSCSPRAL;GVREGQNP 2 6.6 1.0036 -1.0561 0 0 0 0 0 0 0 0 0 0 0 0 0 7.79786 10.2345 A0A8C0SSY7 A0A8C0SSY7_CANLF Protein transport protein sec16 SEC16A Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; protein transport [GO:0015031] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] EGAAGGSANPEPASE;EQEELRSFPGPLGK;GALSMFFQGGETENE;GVSAPQAR;HYGSRFRDPRTC;KKTTKLVLIGS;LQNQPVLIAQPDQSYNLAQP;NPLTQGNSPESHL;SAAALPGPELP;VGLAGGGGPNLEAPDSAPH;YWYDAAEYDPYRKESY 11 6.6 1.0028 -1.5367 0 9.0022 0 0 5.72939 0 10.276 0 0 0 0 9.21138 11.9427 0 5.47729 A0A8C0SSZ5 A0A8C0SSZ5_CANLF POC1 centriolar protein homolog B POC1B Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriole [GO:0005814]; ciliary basal body [GO:0036064] LPDKGEEINRYFLNPSLLSPDC;LPSESQRSIPLAVT;TSVDFSPSGKQLGEFCSGPLCCCW;VLLWRTNFDYL 4 9.9 0.86831 0.18818 0 5.21019 7.79662 0 0 0 0 0 0 0 0 0 0 6.72629 0 A0A8C0ST01 A0A8C0ST01_CANLF RHO family interacting cell polarization regulator 1 RIPOR1 Canis lupus familiaris (Dog) (Canis familiaris) GRGRTSARRGRGPR;GVLGSHERGP;LEVTWSPFDKDD;LSTTGPAHT;SELEAQLGE;SPLAPMPQHLDLSPD 6 4.7 0.99062 -0.2677 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9972 A0A8C0ST23 A0A8C0ST23_CANLF Calcineurin-like phosphoesterase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787] ARVLFVIIVLIQLSILIT;EVIVQDSAGRSKSV;EVIVQDSAGRSKSVH;EWPVVLITNPK;KIIPVHLLMLLLY;PGASNIFWGLQISDI 6 11.2 0.99186 0.0094883 7.74839 0 0 0 0 4.14478 0 8.42467 0 0 10.2391 7.52615 0 9.56182 0 A0A8C0ST48 A0A8C0ST48_CANLF Signal recognition particle receptor subunit alpha SRPRA Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] signal recognition particle receptor complex [GO:0005785] ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal recognition particle binding [GO:0005047] ELSKEELIRRKREEFIQKHG;LVDTAGRMQDNAPL;LVDTAGRMQDNAPLM;LVGNEAVDQLV 4 7.5 0.98517 -0.43707 0 0 0 0 0 8.93614 0 0 7.4271 0 0 8.21611 0 0 0 A0A8C0ST51 A0A8C0ST51_CANLF VPS10 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATVGLMLV;HDLEFCLYG;LPLLLLVQLLP;LSRLGRSSQSAPR;RYSVLQQHAEANGV;SAAGRGGAAPA;SGGIIVAI;VYITSVLSED;YTIWLAHS 9 9 0.99736 -3.5256 9.0334 9.33331 0 0 0 8.40799 9.37458 9.35319 0 0 0 6.95233 7.30387 8.31279 3.98094 A0A8C0ST83 A0A8C0ST83_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) dendrite [GO:0030425] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GARRAGSCGASSPPA;LLKKLLVLNPIKRGSLE;VIETEKTLYL;VSYTKRPQANSVESE 4 5.5 0.98754 -0.50183 0 0 0 0 0 0 0 0 10.1576 0 0 0 0 5.64973 0 A0A8C0STA8 A0A8C0STA8_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC21 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] EASEKEVWQQSLQKSFKNL;HYYYFLPV;LIVFVWLYNIVLIPKIVLF 3 17.2 1.0027 -1.0055 0 0 5.43839 0 0 0 0 9.66033 0 0 5.46028 0 0 0 0 A0A8C0STC9 A0A8C0STC9_CANLF HMG box domain-containing protein UBTF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DEDEDEEEEDDENGDSSEDG;DEDEEEEDDEN;DEEDEDEDEEEEDDEN;DEEDEDEDEEEEDDENGDS;DKKRLKWIHKAL;DQKKKDYEVELL;EDEDEEEE;EDEDEEEEDDENGDSSEDGGDSSE;EDEEDEDEDEEEEDDENGDSSE;GDSSEDGGDSSESSSEDESEDGD;SESEEDDEEDEEDED;SESEEDDEEDEEDEDED;SESEEDDEEDEEDEDEDEE;SESEEDDEEDEEDEDEDEEEED;SKSESEEDDEEDE;SKSESEEDDEEDEEDED;WVVPSLWGEGKRI 17 9.6 0.98201 -0.25108 9.69556 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0STE0 A0A8C0STE0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] membrane [GO:0016020] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AGDPGAGA;LHPPPSILSS;SILSSLPPSP;SSPPSILSSLPP 4 4.8 0.988 -0.49219 0 8.30465 0 0 8.75495 0 0 7.44012 7.73071 0 0 0 0 8.67673 0 A0A8C0STE9 A0A8C0STE9_CANLF Adhesion G protein-coupled receptor E2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;GVDELLET;PVGYGVPAVI;QPSLPYPPL;QTLSRFFQRVQDLHREFKPDFVQNT;SLHLQLSICLFLAHLLF 6 9.4 0.98669 -0.3588 0 0 0 8.84257 0 12.8832 0 0 0 0 0 6.44968 0 0 0 A0A8C0STF3 A0A8C0STF3_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DTERTEGAERPLHQ 1 3 0.98482 -0.23875 0 0 0 0 11.6198 0 0 0 0 0 0 0 0 0 0 A0A8C0STH4 A0A8C0STH4_CANLF Kazal-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] AAPSVFRSGV;APPGHCAL;EDYDVSDA;HLSETEPP;LETKVTAL;MAWTLPRPPEVRFIGFST;RSSAFPWPWGI;SEEERSAIARARHFLESSAP;VDGSQQVAFDDSTPVQRQL 9 6 1.0031 -2.4855 5.86698 0 0 10.4185 9.41259 0 0 11.5975 10.4415 0 10.8581 0 12.9261 0 11.149 A0A8C0STJ0 A0A8C0STJ0_CANLF TSC22 domain family member 1 TSC22D1 Canis lupus familiaris (Dog) (Canis familiaris) EDARRPAE;GGGGGGGA;GGGGGGGG;GVESVAQVSQQLPAVSP;SPLNPWKQNIQLLERVGKDNKQ;TLSHYTESVGS;VGKDNKQVGAFHYLLGFIY 7 7.7 1.0031 -0.86329 0 0 12.1227 0 0 9.95722 0 0 0 0 7.08279 0 10.4186 0 9.00363 A0A8C0STJ4 A0A8C0STJ4_CANLF AP-2 complex subunit alpha AP2A1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] AP-2 adaptor complex [GO:0030122] clathrin adaptor activity [GO:0035615] ENQLLQIGV;IVTNRDDVQ;LITCPAFSSP;THIDTVINALKTE;VGCLLRLEPNAQAQP;VLFENQLLQIGV;VLVNSNSELIRLIN 7 7.4 1.0026 -0.76122 10.041 0 0 0 5.16185 8.71733 8.99828 0 9.77109 6.62901 0 0 0 0 0 A0A8C0STJ5 A0A8C0STJ5_CANLF Olfactory receptor OR8K86 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HLTVATVF;ILVAIIRMSSA 2 6.1 0.99049 -0.26687 0 0 0 0 0 0 0 0 0 0 0 12.4313 0 0 0 A0A8C0STK4 A0A8C0STK4_CANLF SEP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear membrane reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] ubiquitin binding [GO:0043130] GNSFCKRSEYIY;RASGDNKSKSFTGGGY 2 14.4 0.99165 -0.18649 0 0 0 0 0 9.15125 0 0 8.77449 0 0 0 0 0 0 A0A8C0STN1 A0A8C0STN1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] PVCSSPCSPYCCSST 1 6.5 0.95512 0.053874 0 0 0 6.7922 0 0 0 0 0 0 0 0 0 0 0 A0A8C0STP5 A0A8C0STP5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AASFGPGP;AGRCARSCCCCCCC;AGRCARSCCCCCCCC;AGRCARSCCCCCCCCCC;AGRCARSCCCCCCCCCCR;CARSCCCCCCCCCCR;CCCCCCCCCC;CCCCCCCCCCR;CCCCCCCCCCRR;CCCCCCCCCR;CKPSAGRCARSCCCCCCCCCC;CQECKPSAGRCARSCCCCCCCC;ECKPSAGRCARSCCCCCCCCC;GRCARSCCCCCCCC;GRCARSCCCCCCCCC;PGVSEAASFGPG;PSAGRCARSCCCCCC;PSAGRCARSCCCCCCCCCCR;QECKPSAGRCARSCCCCCCC;RCARSCCCCCCCC;RCARSCCCCCCCCCC;RSCCCCCCC;RSCCCCCCCC;RSCCCCCCCCC;RSCCCCCCCCCCRRLLP;SAGRCARSCCCCCCCC;SCCCCCCCCCCR 27 10.2 0.98689 -0.49985 4.75344 0 0 0 0 0 0 3.50843 6.44789 0 0 0 0 0 6.29341 A0A8C0STT9 A0A8C0STT9_CANLF RNA binding motif protein 10 RBM10 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] STYQYDETSGYYYDPQ 1 1.9 0.95513 0.049233 0 0 0 0 0 4.99689 0 0 0 0 0 0 0 0 0 A0A8C0STU7 A0A8C0STU7_CANLF "Small ribosomal subunit protein mS26 (28S ribosomal protein S26, mitochondrial)" MRPS26 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial small ribosomal subunit [GO:0005763]; nucleoplasm [GO:0005654] PTVDPVEFFVLTERYRQYRQ 1 9.7 0.9493 0.050028 0 0 0 0 0 0 0 9.11046 0 0 0 0 0 0 0 A0A8C0STW1 A0A8C0STW1_CANLF CCDC66 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cilium [GO:0005929]; microtubule [GO:0005874]; photoreceptor inner segment [GO:0001917] microtubule binding [GO:0008017] ILKGLSELRQVGFN 1 1.6 0.98481 -0.25497 0 0 0 0 0 0 0 13.1222 0 0 0 0 0 0 0 A0A8C0STW6 A0A8C0STW6_CANLF ATP binding cassette subfamily C member 11 ABCC11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GVGLCFALFFTECL;IWDVLEKTFLSM;KAEDFISEFKRLTD;LLIKKIVKIHSHLSEI;PEDTRDSLLPE;QAEVVESGRSFFSV;QEVLLIKKIVKI;TPFMIQGVRRRLN;VLHCCSLNHDLEI;VLLIKKIVKI;VLYVQALKD 11 8.7 0.94737 0.05044 0 0 0 0 4.64553 0 0 0 0 0 0 0 0 0 0 A0A8C0STY9 A0A8C0STY9_CANLF C2H2-type domain-containing protein ZFTA Canis lupus familiaris (Dog) (Canis familiaris) AECLMDYDPRGNRLVCM;GGGEEEEEEEW;LDRRLKESLQNWF;PEDDDDDEDG 4 7.6 0.98323 0.035491 0 0 0 0 0 0 0 5.97932 0 0 0 0 0 0 0 A0A8C0SU00 A0A8C0SU00_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TDTLGVGTGKAMP 1 11.8 0.93509 0.068603 0 9.68741 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SU01 A0A8C0SU01_CANLF MTSS I-BAR domain containing 2 MTSS2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; plasma membrane organization [GO:0007009] cortical actin cytoskeleton [GO:0030864]; lamellipodium [GO:0030027]; ruffle membrane [GO:0032587] "actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; small GTPase binding [GO:0031267]" IPSQGSDYDCYSVNGDADGEGPA;TTVLAAVAFLDAFQK 2 5.1 0.93861 0.10015 0 0 0 0 9.02954 0 0 0 0 0 0 0 0 0 0 A0A8C0SU10 A0A8C0SU10_CANLF ALMS1 centrosome and basal body associated protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule binding [GO:0008017] ADQITGLSTVTPGTYSYSE;APHFNNKMSHSFLHCLLESRG;DTECCNLD;EDDRRKVEEIKAKLFSHE;EKHCIFYPQTL;HNIFYQQAL;LQDLRRFEEVAD;LVIQDNFASPDLPLL;PLEEMDCH;PQMTSEHTRRKHIQVH;QPSELEFVPLRGIPGKS;SDILTQTDREVTLQER;SHREKSNNFYPQELPDK;SKLQKKKRYKSLEKFHK;SQGFELKENRSA;STVPVPTDQRTE;TDGSNDAIAPDFPAE;TYTLDDDTECCNLDENAVV;VISKGHVSFPH;VLHNSYSQ;YSLGEKHSI 21 5.8 0.98936 -0.20347 0 0 0 0 0 0 0 0 9.02727 0 8.93555 0 0 0 0 A0A8C0SU12 A0A8C0SU12_CANLF peptidylprolyl isomerase (EC 5.2.1.8) SS18L2 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] DIEINREPVGRIM;GEATSDSESEFGEI;GHHKKRRKEKKVKHKKKTKKQKH;KKRRKEKKVKHKKKTKKQKHCRRHK;KSSCDRERRSRSSSL;PATKSSAS;RSYSRSYTRSR;SDRSSESSPRSRSR;SETKSRHRTRSVSYSHSRSRSR;TDQPAKED;VFEKKRKK;VISGFEVIEQIENLKTDA 12 11 0.99908 -3.1979 15.0887 9.79346 0 0 11.5451 9.66688 4.71606 7.97361 12.2755 0 0 0 0 8.56098 0 A0A8C0SU22 A0A8C0SU22_CANLF Microtubule associated protein 6 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017] AGGPAAGKPSGGD;KKTSATHKPPRKAKDK 2 6.6 0.8679 0.135 0 0 0 0 0 0 0 0 12.976 0 0 0 0 0 11.9529 A0A8C0SU29 A0A8C0SU29_CANLF Nedd4 family interacting protein 2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion transport [GO:0030001]; vacuolar transport [GO:0007034] cytoplasm [GO:0005737]; membrane [GO:0016020] FEIRKKFEFESYLYQCPNFKFLNC 1 6.6 0.97178 0.041303 0 0 0 0 0 0 0 0 10.2732 0 0 0 0 0 0 A0A8C0SU39 A0A8C0SU39_CANLF Anion exchange protein SLC4A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;EATLVLVGKQLVPPLIPITP;EEQIRPQDRDLLLRVL;LILTVPLRRLLLPLIFRKL;LLLRVLLLKH;LLRVLLLKH;LTVPLRRLLLPLIFRKL;PLRRLLLPLIFRKLE;VGVAGCQG;VPLRRLLLPL 10 8.3 0.99893 -2.949 8.78722 0 0 4.14053 0 0 0 0 9.25394 0 0 5.51759 6.45493 4.50144 0 A0A8C0SU43 A0A8C0SU43_CANLF DENN domain containing 5B DENND5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] ECRMKGKSALWSH;GIDADSGL;GVYEPVICQRPGPN;IRLSLEKKLLSQ;LDAPVPYLMG;QFHSFIITREDG 6 5.5 0.93959 0.059848 0 0 0 0 0 0 0 0 0 0 0 0 6.42326 0 0 A0A8C0SU48 A0A8C0SU48_CANLF "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.64) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737] phosphatidylinositol phosphate phosphatase activity [GO:0052866] HNIHVMRESL;YVRWNPRMRPQENRQQ 2 3.7 0.96138 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 12.1072 0 0 A0A8C0SU55 A0A8C0SU55_CANLF Dynactin subunit 6 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] dynactin complex [GO:0005869]; membrane [GO:0016020] dynein complex binding [GO:0070840] MAEKAQKSVKIAPG;QTLQLDFLM;SPASGSLHGACFSLCLC 3 10.9 0.99158 -0.18332 0 0 0 0 10.6582 0 0 0 0 0 0 0 0 5.70852 0 A0A8C0SU67 A0A8C0SU67_CANLF Vimentin Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] AEGIMRLLEKQQEEMLQREEA 1 5.2 0.97826 0.047674 0 0 0 0 0 0 0 0 0 0 6.91241 0 0 0 0 A0A8C0SU77 A0A8C0SU77_CANLF Myosin motor domain-containing protein MYO1B Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ELKRIFHLWR;GVGLICMIMKSEPAH;IAAWYRRYAQ;PSLSPIDMNWP;QEKVSTTLNVAQAYY;RYLGLLENVRVRRA;TVTDETFL 7 7.9 0.98659 -0.23299 0 0 0 0 0 0 8.08789 0 0 0 0 0 0 0 0 A0A8C0SU78 A0A8C0SU78_CANLF Solute carrier family 29 member 4 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] monoamine transmembrane transporter activity [GO:0008504]; nucleoside transmembrane transporter activity [GO:0005337] DDRYHAIYFAML;RILTKLLLPDE 2 4.7 0.94114 0.085931 0 0 7.49394 6.83466 0 0 0 0 0 0 0 0 0 7.95739 0 A0A8C0SU84 A0A8C0SU84_CANLF PNMA family member 6E LOC111094960 Canis lupus familiaris (Dog) (Canis familiaris) LVEFAQYLNRSLIPRQTA 1 3.2 0.97319 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.5718 0 0 A0A8C0SUA7 A0A8C0SUA7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ASPCSASPCCQQSSCQPSCCSSSP;ESSPCSQQSSCQPSCCSSSP;QPSPCRPS;VCCTPVCCKPVCCE 4 11.2 0.99166 -0.29261 0 0 0 0 0 0 0 0 0 0 9.93727 0 0 0 0 A0A8C0SUA9 A0A8C0SUA9_CANLF MPN domain-containing protein ACTG2 Canis lupus familiaris (Dog) (Canis familiaris) protein K63-linked deubiquitination [GO:0070536] K63-linked deubiquitinase activity [GO:0061578]; metal-dependent deubiquitinase activity [GO:0140492] DIPPRRYFRSGVE;DYKSAVIPEKKDTVKKLKEI;GDDAPRAVFPSIVG;GFHPHSKDPPLFCVLQ;LSSVDLHTHCSYQ;YIEYNEEKKREAEELARNV 6 20.3 0.81156 0.21252 0 12.7507 6.64659 0 12.271 0 0 8.1573 9.4591 0 0 0 0 12.7791 0 A0A8C0SUB1 A0A8C0SUB1_CANLF Cytochrome b-245 heavy chain (CGD91-phox) (Cytochrome b(558) subunit beta) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; monoatomic ion transmembrane transport [GO:0034220]; superoxide anion generation [GO:0042554] monoatomic ion channel complex [GO:0034702]; NADPH oxidase complex [GO:0043020] superoxide-generating NAD(P)H oxidase activity [GO:0016175] PFGTASEDVFSY 1 2.3 0.95418 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.29687 A0A8C0SUD9 A0A8C0SUD9_CANLF Galectin Canis lupus familiaris (Dog) (Canis familiaris) eosinophil chemotaxis [GO:0048245]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; RNA splicing [GO:0008380] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; immunological synapse [GO:0001772]; spliceosomal complex [GO:0005681] carbohydrate binding [GO:0030246]; IgE binding [GO:0019863]; laminin binding [GO:0043236] ISDDIDLTSFICY;NQPAGAGG 2 8.2 0.9873 -0.26005 0 0 0 0 0 0 0 8.45861 0 0 0 0 0 0 0 A0A8C0SUE6 A0A8C0SUE6_CANLF Zinc finger and BTB domain containing 47 ZBTB47 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AHSEQEEEEEEEEGHSEQDQESSE;DEEEEAHSEQEEEEEEEE;DEEEEAHSEQEEEEEEEEG;EEGGSQGEEEDEEEEAHSEQEEEE;FPAHKGVLAAYSQF;GRLNEQRLFQPDLC;HSEDEEEEEEEDEE;HSEDEEEEEEEDEEE;KDFNMKQYFDEHMKTHTGEKPY;QRHSEDEEEEEEEDEEE;VLGREDGLQRHSEDEEEEEEEDEEE 11 15.1 0.74571 0.24383 0 0 6.58984 7.91558 6.21156 8.18958 0 0 5.26367 0 8.84925 0 8.24356 0 10.9827 A0A8C0SUE7 A0A8C0SUE7_CANLF RNA-polymerase II-associated protein 3-like C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GEGEGGGKRPERGAPRRG;PPAPAALGPAAL;TNGPPECDEELPITKPN 3 5 0.98807 -0.47201 0 0 0 8.92976 0 0 0 8.71263 0 0 15.9701 0 0 0 0 A0A8C0SUG0 A0A8C0SUG0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPYCCS;QPSPCRPS;SSPCSASPCCQQSSCQPYCCSSTPC 3 13.6 0.97364 0.035538 0 0 8.50847 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SUH2 A0A8C0SUH2_CANLF Oxysterol-binding protein OSBPL1A Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] DEFYDALSESE;LELLEHSE;LETLATEHHELE;SSRFFGWRL;TSEESDEMPMPD;VIFNEPLSFLQRLTEYMEHTY 6 8.4 0.99876 -0.61092 0 0 0 0 0 9.34087 0 0 13.8393 0 6.63776 7.28188 0 0 9.46976 A0A8C0SUL7 A0A8C0SUL7_CANLF Myosin IB MYO1B Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ELKRIFHLWR;IAAWYRRYAQ;LEASELFKDKKALYPSSVGQPFQ;PSLSPIDMNWP;QEKVSTTLNVAQAYY;RYLGLLENVRVRRA;TVTDETFL;VYTNFALSDEAYRSLR 8 10.4 1.0032 -2.1341 9.81708 0 9.45265 0 0 0 12.7366 9.38597 0 5.39111 0 0 0 0 0 A0A8C0SUM6 A0A8C0SUM6_CANLF Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (Tetrahydrofolylpolyglutamate synthase) FPGS Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326] HEATLEAGAPLTGDRLLERRAT;LDQVLLRCLAHQQHWSHLN;PELFTKHFWHLYH 3 9.9 0.97467 0.046969 0 0 0 0 0 9.6113 0 0 0 0 0 0 0 0 0 A0A8C0SUM8 A0A8C0SUM8_CANLF Leucine rich repeats and calponin homology domain containing 2 LRCH2 Canis lupus familiaris (Dog) (Canis familiaris) AAGGGGGG;GAGGGGGG;GGGGGGGG;GSGYDLTDTTQADLSRNRFT;KPKQTVECEKSVSADEVNSPLSP;LDLPSLSKR;NSGGGGCG;RNLLSTLPKYLFDLP;VPRNKPKQTVECEK;WNPGSLQPQ 10 13.9 1.0021 -1.8814 9.84585 0 0 0 0 0 0 9.22074 0 6.64803 10.719 5.17361 0 10.3021 9.99661 A0A8C0SUM9 A0A8C0SUM9_CANLF Codanin-1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ERGQARRLLHLLLSL;ITALIRREVKAAVSRTLR;NLEEFPPVGSL;QPPSLRRTVE;SEHGLDGMPVVDQH;VAPQSSGG 6 6.2 1.002 -1.8314 8.28697 8.55175 0 0 5.8594 0 0 11.9198 10.8243 8.61861 9.48178 8.97977 0 8.92038 0 A0A8C0SUQ4 A0A8C0SUQ4_CANLF Tumour necrosis factor receptor 13C TALL-1 binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tumor necrosis factor-mediated signaling pathway [GO:0033209] membrane [GO:0016020] signaling receptor activity [GO:0038023] AAAPPGAPDPQ 1 6.1 0.98954 -0.22243 0 0 0 0 0 0 0 9.67844 0 0 0 0 0 0 0 A0A8C0SUQ9 A0A8C0SUQ9_CANLF Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) CCHCR1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] cytoplasm [GO:0005737]; nucleus [GO:0005634] AMQEEELTRKVQPAD;QEQAILQRS 2 3.3 0.99581 -0.11589 0 0 9.96475 0 0 0 7.77123 9.76157 0 0 0 0 0 0 0 A0A8C0SUR4 A0A8C0SUR4_CANLF PAT complex subunit CCDC47 (Coiled-coil domain-containing protein 47) CCDC47 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum calcium ion homeostasis [GO:0032469] rough endoplasmic reticulum membrane [GO:0030867] calcium ion binding [GO:0005509] DTKRTLLFTF;FEDADTQEGDTESEPYDDEE 2 6.7 0.99517 -0.56325 0 0 0 0 0 0 0 9.07355 0 0 0 0 0 7.23946 0 A0A8C0SUR7 A0A8C0SUR7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACPGPCQPSCGSCSPCQEGCC;CCKPSSPCCQQSSCQPSCCNSSP;CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;EASPCCQQSSCQPSC;PCCQQSSCQPSCCNSSPCQEGCC;PSCCNSSPCQEGCCVSVCC;QPSCCNSSPCQEGCC;SCGSCSPCQEGCCM;SPCQEGCCMSVCC 11 33 0.97839 0.046253 0 0 7.06059 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SUY0 A0A8C0SUY0_CANLF NEDD4 binding protein 2 like 2 N4BP2L2 Canis lupus familiaris (Dog) (Canis familiaris) DIQGGSTD;DRYEYEMSI;EDTKRESVHDF;FLVLLKILTI;KIMGENSFEILSYHIPGDQDPS;KLQKLLILLRGLP;LFGSPGVP;SVFLVLLKIL;YHLNIQRF 9 7.5 0.99704 -3.9323 0 10.0044 0 0 0 5.90277 0 10.5696 7.60043 0 0 0 0 0 0 A0A8C0SUY8 A0A8C0SUY8_CANLF Peptidase S1 domain-containing protein LOC100684662 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DSCQGDSGGPLVCEFRETW;EFRETWVQVGIVSWGIGCGHKNSP;VGPRRRPRRPPRRPPRR 3 11 0.95321 0.049524 7.2485 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SUZ4 A0A8C0SUZ4_CANLF Adhesion G protein-coupled receptor E2 ADGRE2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;ATTCRCSPGFSSLSGE;GEIFSSPLESCDD;GVDELLET;GVDELLETPGDLEAL;SLHLQLSICLFLAHLLF;TEIKVLCSI;TVGSYQCRCRRGWEPK;VDELLETPGDLEAL;YHCMCSPGYA 10 13.1 1.0018 -2.626 0 0 0 9.48468 0 7.84166 0 8.93446 0 0 10.4642 0 10.6964 9.22656 0 A0A8C0SUZ8 A0A8C0SUZ8_CANLF Tectorin alpha TECTA Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] extracellular region [GO:0005576] CTSSCPDTCSDLTASQNC;DTCSEGCQCDEGYALL;EDNGGCEQICTS;ETFWVDLDCQIF;EVHLHCAVSLCD;GASEVKLNGQEVELP;HYLTFDGFAFDFQTSCPLILCTTG;HYSVCTSSCPDTCSDLTASQN;ISKCKLFQLGFEREGVRI;IVIHRAYKHT;LDLGAVKIYQ;LDWCEDNG;LDWCEDNGGCEQI;LEMPMGLLASSVSEFG;NSHFEECVTCMETCETL;PLPFYESCYLDGCY;PSCTKVEGF;PYEVCEPKGKF;SEGCQCDEG;VGADCPNRTCELENGGELCGC;VTVQYSDIGLL 21 11.8 1.0021 -2.5939 8.52129 7.90358 0 11.299 12.5624 13.5908 4.76405 10.7451 0 9.06563 0 10.8909 10.1989 0 11.1235 A0A8C0SV21 A0A8C0SV21_CANLF Carboxylesterase type B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; synaptic vesicle endocytosis [GO:0048488] cell surface [GO:0009986]; plasma membrane [GO:0005886]; presynapse [GO:0098793] carboxylic ester hydrolase activity [GO:0052689]; neurexin family protein binding [GO:0042043]; signaling receptor activity [GO:0038023] ARYHIAFGPVIDGDVIPDDP;DAAHGDEVPYVLGIPMIGPTELF;HSNFGSPTYFYA;LNDISQYTSTTT;WTRYSQKDQ 5 9.2 0.99869 -0.60831 0 0 5.25561 0 0 7.01703 9.15808 0 0 9.23355 0 9.47269 0 0 0 A0A8C0SV30 A0A8C0SV30_CANLF Myosin IXB Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; Rho protein signal transduction [GO:0007266] myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] DERNYHVFYYLL;DVLKVTTCVEMLIKEQ;ERNYHVFYYLLLGVSE;GKFIQVNYLE;LSQLLKVKREILVEVLTKRKT;LYRDLHDQ;MAVLREAGQLRAERAEKAA;QLDGTKCYVL;SERLASAVLWRGKK;SQSRASCRVTATKDS;YHVFYYLL 11 6 1.002 -1.8816 0 10.0444 10.6132 8.76832 11.2512 8.10318 0 0 9.4644 9.2533 8.56014 0 9.24759 11.4415 12.697 A0A8C0SV32 A0A8C0SV32_CANLF Angiopoietin like 8 ANGPTL8 Canis lupus familiaris (Dog) (Canis familiaris) cell maturation [GO:0048469]; cellular lipid metabolic process [GO:0044255]; fat cell differentiation [GO:0045444]; positive regulation of protein processing [GO:0010954]; regulation of lipid metabolic process [GO:0019216]; regulation of lipoprotein metabolic process [GO:0050746]; triglyceride homeostasis [GO:0070328] extracellular region [GO:0005576] ALREVAQGQQMLRESM;GLEPAKQEEL;RGAWLGHSRQEFEALKAHADK 3 23.7 0.9896 -0.51742 0 0 0 0 0 8.0237 0 0 0 0 0 0 0 0 8.50522 A0A8C0SV38 A0A8C0SV38_CANLF Ig-like domain-containing protein NEXN Canis lupus familiaris (Dog) (Canis familiaris) QEIKEMLASDDEEE;QYIERGETYCLYLPETF;RNQRRSRDEKQRRKEQYIREREWNR 3 8.4 0.97948 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.10329 A0A8C0SV54 A0A8C0SV54_CANLF G-protein coupled receptors family 1 profile domain-containing protein HRH4 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of MAPK cascade [GO:0043408] plasma membrane [GO:0005886] histamine receptor activity [GO:0004969] KSNLLLSLRAQM 1 3.3 0.94446 0.05044 0 0 0 5.56727 0 0 0 0 0 4.49653 0 0 0 0 5.62237 A0A8C0SV67 A0A8C0SV67_CANLF SH3 domain-containing protein MIA3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] AERAIAEEKRE;DLQIQILKEPSQ;EDNFPQDHTEDL;FPQDHTEDNFPQDHTEDL;NEILDDTAKNLRVMLESEREQN;NRFHSWKSLYPGNTPCTG;PRPLPPPFGMMIE;QTNAEEPASV;VEVNSEESE;VGGPLPPPIRYGPPPQLCGPFGP;VGKDEEENEDNFDE 11 8 1.0045 -2.0135 9.54581 7.79006 11.6149 10.2767 0 0 0 0 9.30035 0 0 0 0 6.39041 0 A0A8C0SV68 A0A8C0SV68_CANLF Globin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744] blood microparticle [GO:0072562]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] haptoglobin binding [GO:0031720]; heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] EEKSLVSGL;EVGGEALGRLL;GKVNVDEVGG;PENFKLLG;PENFKLLGNVL;TAEEKSLVSGL;TFAKLSELH;VDPENFKVCIGRKELRMF;VHLTAEEK;VHLTAEEKS;VHLTAEEKSL;VHLTAEEKSLV;VHLTAEEKSLVS;VHLTAEEKSLVSG;VHLTAEEKSLVSGL;VHLTAEEKSLVSGLWG;VHLTAEEKSLVSGLWGKVNVDEVG 17 44.4 0.96655 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 9.4374 0 0 A0A8C0SV72 A0A8C0SV72_CANLF "Myosin light chain 3 (Myosin light chain 1, slow-twitch muscle B/ventricular isoform)" Canis lupus familiaris (Dog) (Canis familiaris) myosin II complex [GO:0016460] calcium ion binding [GO:0005509] HGGGGAGV;SPCACLQDSCTEC 2 8.1 1.002 -1.4359 0 8.48378 0 8.10129 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SV82 A0A8C0SV82_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVGGGRQGVPRGSHW;PAREPTGALARGARPDAAMSAA 2 7.3 0.93404 0.068595 0 0 0 0 0 0 0 9.67271 0 0 0 0 0 0 0 A0A8C0SVA9 A0A8C0SVA9_CANLF Transmembrane protein 202 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ETNEGVSTWMNQEPKRQSGSVV;ISLTKGPG;PYRMHHFSSL;SALIILIIIIWL;VVQPRVHITG 5 15.3 0.50898 0.47678 12.3716 12.4164 12.2366 7.94433 8.78405 8.48232 11.64 12.4141 11.7602 0 11.7997 11.7081 12.5842 12.6947 12.6233 A0A8C0SVB1 A0A8C0SVB1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;WNQKRPRITRGILKKKTI 5 4.8 0.97368 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.56523 0 0 A0A8C0SVD0 A0A8C0SVD0_CANLF Fanconi Anaemia group E protein C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ATVLTKSLFLRRI;ELKPLLLRLP;LATALELNTTFL;TVLTKSLFLRRI 4 5.8 0.98326 -0.25611 0 12.1874 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SVD5 A0A8C0SVD5_CANLF U-box domain containing 5 UBOX5 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450] MDCSTDPVSHEQKLSQ 1 3.1 0.98536 -0.23254 0 0 0 0 0 0 0 0 0 0 0 0 0 8.85748 0 A0A8C0SVE0 A0A8C0SVE0_CANLF Sin3 C-terminal domain-containing protein SIN3B Canis lupus familiaris (Dog) (Canis familiaris) transcription corepressor activity [GO:0003714] EGVCGTNEIGTHRA;GTLCRAKQVQPLVL;QYEDTLREMFTIHAY;VELEEYYPAFLDMVRSL 4 9.1 0.93926 0.069687 0 0 0 0 0 0 0 0 0 7.93204 0 0 0 0 0 A0A8C0SVF8 A0A8C0SVF8_CANLF HMG box domain-containing protein HMGB3 Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; innate immune response [GO:0045087]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" EVPVNFAEFSKKCSERWKTMS;LSDSEKQPYNNKAA 2 17.1 0.91467 0.10923 0 0 8.85941 6.348 0 7.6017 0 0 0 0 0 8.9446 0 0 9.62353 A0A8C0SVG5 A0A8C0SVG5_CANLF Adenylyl cyclase-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] plasma membrane [GO:0005886] actin binding [GO:0003779] CEIVSAKSS;QNLAGGLEKVVGCLEAVSNAS;SIQALGWVAMAPKPG;WVKAHLSIWTELQA 4 17 0.99562 -0.082624 10.1343 9.02967 0 0 0 0 11.8275 0 0 0 10.9636 0 0 8.90917 0 A0A8C0SVM4 A0A8C0SVM4_CANLF Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) PEA15 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042] cytoplasm [GO:0005737] EDIPSEKSEEI;GRLVFLGA 2 5.9 1.0022 -1.2176 0 0 0 0 0 0 0 0 7.8604 0 0 0 0 7.31352 0 A0A8C0SVS2 A0A8C0SVS2_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGYSGDDCGV;DCAIQCREGSCVCQDGYAGED;GEDCGLRTCPSNCH;GSCPDDCNDQ;MPSSPPSASGSCPDDCNDQG;PEADGTLLTDLMPG;RDCRGRGRCENGV;SLDGLRGHFERVV;TLCSLHGVFDLSRCACSCEP;VCDPGYAGDDCGSRSCPWDCGE;YEGADCGARSCPGGCHG 11 10.8 0.97575 0.047166 0 0 0 0 0 0 0 0 0 0 0 8.74325 0 0 0 A0A8C0SVU4 A0A8C0SVU4_CANLF Zinc finger and BTB domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAGGGGGG;RRRRRRRRRRRRRRRRRGE 2 3.6 0.95505 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 6.85898 0 0 A0A8C0SVV7 A0A8C0SVV7_CANLF Glutamate receptor Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" kainate selective glutamate receptor complex [GO:0032983]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] DDRVNILGFSIFNQSHAFFQEF 1 2.5 0.97381 0.046699 0 0 0 0 0 0 0 0 7.16169 0 0 0 0 0 0 A0A8C0SVW3 A0A8C0SVW3_CANLF Nexilin F-actin binding protein NEXN Canis lupus familiaris (Dog) (Canis familiaris) AAGGGGGG;GGGGGGGG;GGGGQRAP;GPSGRHEDARR;QEIKEMLASDDEEE;RNQRRSRDEKQRRKEQYIREREWNR 6 14.9 1.003 -1.6273 0 0 0 0 0 0 0 0 0 0 12.6786 0 0 10.5864 0 A0A8C0SVW4 A0A8C0SVW4_CANLF ZBR-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of meiotic nuclear division [GO:0045835]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088] zinc ion binding [GO:0008270] DTVKKSGHLRRLRRL;GVSCKATHFNGRIKFILILWK;NELLQPCNF;VSGKKFLLRRR 4 8.1 1.0019 -0.9677 0 4.2163 0 0 0 0 0 3.7182 0 0 0 0 0 0 10.4953 A0A8C0SVW8 A0A8C0SVW8_CANLF Nucleoporin 205 NUP205 Canis lupus familiaris (Dog) (Canis familiaris) nuclear pore [GO:0005643] ALLYCFDISFLEQST;EIGRMLALALLD;GTEGRTGPVAVRESPQLAE;HLLNESPMLE;IVSVDKQQQWLLY;LEYWCPSEPLQTSTI;NVEQLPPDEIKELCQSVMPVGVE;QAAGQVLQFLISHSDTIQA;RRRLVKLINNRAKLLSL;RVLVAEVN;SIDFSQEIP;TDSQDSLF 12 8.6 1.0018 -0.67553 5.45085 0 4.50906 3.85788 8.52619 8.20433 7.80678 6.87909 11.1447 0 0 9.83621 9.86391 8.73721 9.97413 A0A8C0SVX8 A0A8C0SVX8_CANLF SB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; protein transport [GO:0015031] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] ILPICQVCQVEYLHIHP 1 8 0.97716 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 9.80371 0 A0A8C0SVX9 A0A8C0SVX9_CANLF Protein XRP2 RP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activator activity [GO:0005096] ERPKQYSW;IVSEIFNGTKMFVS 2 6.3 1.002 -1.2308 0 0 9.41329 0 0 0 9.09011 0 0 0 0 0 0 0 0 A0A8C0SVY3 A0A8C0SVY3_CANLF Dynamin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEMWKKTIDKC;DLIKLQRSRILKEKLKRKLP;IKLQRSRILKEKLKRKLPTD;LDPIYIGLF;LDQRFRAFPPVEQSAFKEYE;RGNQGFHQTL;TTCWCCSFCGAVASEMQP;VEEAIWKLQMFY;VIWTQMELMPSAER 9 14.2 1.0027 -1.1935 4.13759 10.2479 0 0 0 0 8.69606 0 14.0543 0 0 10.2431 8.49362 9.6247 0 A0A8C0SVY4 A0A8C0SVY4_CANLF Protein VAC14 homolog VAC14 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol biosynthetic process [GO:0006661] endosome membrane [GO:0010008]; PAS complex [GO:0070772] EIASSPAGQTDD;EVTVDFLTEVDKLV;LVTPEDDEPD;SHSELQVPTPGRANLLNT 4 6.9 1.0018 -1.2887 0 0 0 0 0 0 12.4176 7.7699 12.5866 0 0 10.0929 0 0 0 A0A8C0SVY6 A0A8C0SVY6_CANLF Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAAAVEQRSRFEYPPPPVSL;LSSGFKYLEYEKK 2 4.3 0.98909 -0.26508 0 0 0 0 0 0 0 9.84139 0 0 0 0 0 0 0 A0A8C0SVY8 A0A8C0SVY8_CANLF EvC ciliary complex subunit 2 Canis lupus familiaris (Dog) (Canis familiaris) smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] AELRRWEHLIF;AGYLDEEQMEALLERARM;KLHQKLILKRRR;LERHQQSWREERDH;LSVLKILEPPIIVW;NEDLALNDQMI;QEKKKLHQKLILKRRRE;QELERKLEDKLA;VLKILEPPII 9 8.5 0.99166 -0.55069 0 0 5.35727 4.42687 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SW12 A0A8C0SW12_CANLF C2H2-type domain-containing protein NUFIP1 Canis lupus familiaris (Dog) (Canis familiaris) EPRTHHPYL;HCFCDTCDR;VNLPPSRK 3 5.7 1.0037 -1.6836 5.85142 0 11.9336 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SW13 A0A8C0SW13_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein heterodimerization activity [GO:0046982] EAARRLAGLLRRALIRVAREAQRLS;EAMYYSAEHGYV;GGGGGGGG;GGGGGGPG;LAAIFTHCYGSSPVPSI;LHEDMNCFSHSAAHGHRNVLR;PGLKGGAA;PSIHPDSRH;RLAGLLRRALIRVAREA;VINNDAELWGVLQPYEH;VLPEDPEVA 11 10.6 0.99894 -3.2456 9.2963 8.76848 0 0 8.57996 0 0 8.63045 13.9271 10.7017 0 0 0 13.532 0 A0A8C0SW15 A0A8C0SW15_CANLF P-type Cu(+) transporter (EC 7.2.2.8) ATP7A Canis lupus familiaris (Dog) (Canis familiaris) copper ion homeostasis [GO:0055070] membrane [GO:0016020]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; P-type divalent copper transporter activity [GO:0043682] GVYHIKVSLE;LEVVLMTGDNSRTARS;LVLQPWMGS;VETKTSSK;VGIPIAAGV 5 3.7 0.99032 -0.26592 9.32071 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SW24 A0A8C0SW24_CANLF CaM kinase-like vesicle-associated protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] EEDDYENHDKNLFRK;VTLGDKKNYNQPSEVTDRY 2 7.8 0.93869 0.10343 8.80584 0 0 7.13422 0 0 0 9.48818 0 0 0 7.82063 0 0 0 A0A8C0SW28 A0A8C0SW28_CANLF PDS5 cohesin associated factor B Canis lupus familiaris (Dog) (Canis familiaris) mitotic sister chromatid cohesion [GO:0007064] nucleus [GO:0005634] MDDLTKLVQE;SEMDHSEN;VQLNPHNPHHRKDEEDHQKRHHH 3 2.9 1.0035 -1.7003 0 0 0 0 0 0 0 8.89733 0 0 0 5.22635 0 0 0 A0A8C0SW33 A0A8C0SW33_CANLF Adhesion G protein-coupled receptor E3 ADGRE3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;ETFFEEANEK;HAYCVNGTQCTCD;LVIFLLVLWILKKKL;SLHLQLSICLFLAHLLF;TTLPGMGEKGEV;WQRALFLMTWLAF 7 12.9 0.98208 -0.25056 0 0 0 6.60452 0 0 4.77768 9.15302 0 11.7006 0 0 0 0 0 A0A8C0SW46 A0A8C0SW46_CANLF Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) TAOK3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytoskeleton organization [GO:0051493] cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DLHEIGHG;HGDPRPEPRPTQSVQSQALHYRNRE;QEMELLNAYQSKIKMQTE;SIWSSTLS;YHIAQNDSPTLQS 5 8.1 1.002 -1.4643 0 0 0 0 0 0 8.32459 0 7.25181 1.16922 0 8.03755 12.1837 0 0 A0A8C0SW58 A0A8C0SW58_CANLF Catalase (EC 1.11.1.6) CAT Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] catalase activity [GO:0004096]; heme binding [GO:0020037]; metal ion binding [GO:0046872] DKLNVMTAGPRGP;VGKLVLNRNP 2 4.5 1.0027 -0.75645 0 0 0 0 0 0 10.856 0 0 0 0 0 0 0 10.1882 A0A8C0SW69 A0A8C0SW69_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RWAGSSAG 1 33.8 0.98997 -0.26592 12.0163 11.5464 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SW75 A0A8C0SW75_CANLF Transcription factor EC TFEC Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] LEYGWCGQ 1 2.3 1.0042 -1.1044 0 0 0 0 0 0 0 0 9.22468 0 0 0 0 0 0 A0A8C0SW94 A0A8C0SW94_CANLF Kringle-containing protein marking the eye and the nose Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] membrane [GO:0016020] IVAKILLH;LFWNETFQHPY;LLILTVTAIVAKILLHI;LVSQPSCPGVGYFSNLPA;SAARSSKV;VGACGGNY;VGTRRRSPG;WNETFQHPYNTLKYPNGEG 8 9.1 0.99723 -3.7202 3.05613 0 0 0 6.78241 5.69577 8.21733 0 4.08712 9.17667 8.34722 0 8.64165 0 12.4703 A0A8C0SW97 A0A8C0SW97_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVATCQVLPKS;LAPASKKFGL 2 8.6 0.9901 -0.26579 0 0 0 0 0 0 0 0 0 0 0 12.7001 0 0 0 A0A8C0SWA4 A0A8C0SWA4_CANLF Rap associating with DIL domain Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] metal ion binding [GO:0046872]; pore-forming activity [GO:0140911] QMHPEIASQVL;SDGRLSLGDRILEVN;SSTEDFCY;TPALASEG;VDTLTAGINAQA 5 4.1 1.0027 -2.5297 9.04895 8.53679 8.92603 8.84464 11.5995 0 0 0 0 0 0 0 0 0 8.96278 A0A8C0SWB3 A0A8C0SWB3_CANLF Scaffold protein involved in DNA repair SPIDR Canis lupus familiaris (Dog) (Canis familiaris) AGLFSLIDTMWPPV;EALTEAAPHCFLFRDALRTQ;GLAERLNGLQ;LAKKKKLL;VGEISDCASCSSSHS;VGEISDCASCSSSHSSTSQ 6 7.1 1.0026 -1.7661 0 0 6.6907 4.78983 0 4.91757 7.45746 0 11.0163 9.42517 0 0 0 0 0 A0A8C0SWD1 A0A8C0SWD1_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] NAD+ ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779] HTRLFSCGIGSTANRHMLR;LVSFILPAYVIKRLILLVLRVS;PAYVIKRLILLVLRVSNSLV;PPSLAKYRALRCKIEHVEQNTEE;TANRHMLRTLSQYG;VAKYNTLEKIGAK;VLVSFILPAYVIKRLILLVLR 7 6.7 0.98644 -0.4566 9.93858 9.94784 10.1221 0 0 0 9.8475 10.1504 0 0 7.65943 0 10.3721 10.3582 10.7413 A0A8C0SWD3 A0A8C0SWD3_CANLF G-protein coupled receptors family 1 profile domain-containing protein RXFP1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; protein-hormone receptor activity [GO:0016500] AKRFFFIVFT;EGIEISNIQQRMFRPLM;GVDDCGNQADEDNCG;NIFVICMRSHIRSEN;TTRPFKEMIHQFWYNYRQRRSIDS;VDDCGNQADEDNCGDNNGWPLQFDK;VVIFILPINS 7 14.9 0.9981 -0.60556 0 0 7.29563 0 8.59716 0 9.71696 10.0132 0 8.62194 0 0 0 11.2337 0 A0A8C0SWD5 A0A8C0SWD5_CANLF Gasdermin pore forming domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VTGAMNVSIGLPVQVTGSS 1 10.9 0.94956 0.054236 0 0 0 0 0 0 0 0 0 0 0 0 0 12.36 0 A0A8C0SWE0 A0A8C0SWE0_CANLF Zinc finger protein 662 ZNF662 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] EGNFEEAKDH;GVLKSEKEDFIL;VLKSEKEDFI 3 5.2 0.99299 -0.14368 0 0 0 12.9029 11.12 12.0699 13.2209 14.6931 12.7796 0 0 0 11.676 0 10.3387 A0A8C0SWE7 A0A8C0SWE7_CANLF WD repeat domain 87 Canis lupus familiaris (Dog) (Canis familiaris) AGKEPGPLEGE;AKPQSKVSSKILKALQDLTK;DTTNSNPLIRELAWE;EAEKKLTQLEESL;EEEKRSWEKEIIRK;EGAIREDIMTE;EITSMEALNATEL;EKKKKKKKKKV;EPYRSARAEQVS;EQESLSEEEEEEEEEEEEEEEEEEE;GQLGEVQRFTSTT;IQEEEEEELTEDEE;KEKEKKEKKKKKKKK;KKKKKKKK;KKKKKKKV;KKKKKKKVE;KRKKLMENKLKLAQE;KSEDLVEKRTFSMS;KYLKVIPPI;LQDLTKEEMKLTQE;LSEEEEEEEEEEEEEEEEEEEN;LTLKLLRKI;NYVHLSEAVLE;PGLKTPYLFQILRKTIE;QDLTKEEMK;SEEMESLVGEVE;SLSEEEEEEEEEEEEEE;SLSEEEEEEEEEEEEEEEE;VGEVEQESLSEEEEEEEEEEEEEE;VGEVEQESLSEEEEEEEEEEEEEEE;VILKKGKKKKAIFLK;VILKKGKKKKAIFLKSD;VILKKGKKKKAIFLKSDGL;VIPLLGQKKGRKLKTMDIPQKEVP;YYVLRMLQQRYAKDHAAWME 35 11.7 1.0038 -0.80421 0 0 0 0 0 4.27813 0 0 0 0 0 0 0 0 0 A0A8C0SWF6 A0A8C0SWF6_CANLF Nucleoporin 37 NUP37 Canis lupus familiaris (Dog) (Canis familiaris) kinetochore [GO:0000776]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654] ENLFATTGYPGKIASQFQIHH;VGSGLSWHRTLPLC 2 8.2 0.99204 -0.17727 0 8.48253 10.322 0 0 0 0 9.07518 0 0 0 0 0 0 0 A0A8C0SWF9 A0A8C0SWF9_CANLF G protein-coupled receptor 83 GPR83 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] ALRRKKKKTIK;LDHKRVIYI;RAGRARAGKEPRQ;VIHTNNALYFAFHW 4 7.1 1.0025 -1.0218 0 0 9.36043 0 0 0 0 0 0 0 0 0 0 0 9.17218 A0A8C0SWI3 A0A8C0SWI3_CANLF Cyclin-D1-binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] GAGGGGGG;GGGAGVAP;GGGGGGGA;GGGGGGGG;LVSVLKKALEI;QIRRLAVELRLLLPGVR 6 10.4 0.98373 -0.25521 0 0 0 0 0 0 0 7.88209 0 0 0 0 0 0 0 A0A8C0SWJ2 A0A8C0SWJ2_CANLF IQ motif and Sec7 domain ArfGEF 2 IQSEC2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DEALNCHPSGPMSE;ELEGQLDQLTQENRDL;ESELEKQKGMMRP;ESRMSRRIILSNMRMQ;HFILERKGLSRQMIGEF;QENRDLREESQLHRGELHRD;QLLETQRRRIEE;SSVEGDAPGSDLSTAVDS;VTTSGEFSN;YGGSCGGG;YRVESELEKQKGMMRP 11 9.1 1.0022 -1.2373 14.3026 11.7133 10.4317 11.0288 0 6.53154 7.10318 9.81746 11.0235 9.61407 8.38995 0 10.3687 8.98581 10.0163 A0A8C0SWJ5 A0A8C0SWJ5_CANLF Coiled-coil domain containing 17 Canis lupus familiaris (Dog) (Canis familiaris) ESQSRALERRREGEG;LDPHFLLP 2 4.8 1.0022 -1.3221 0 7.12412 0 0 0 0 0 8.15558 0 0 0 0 0 0 0 A0A8C0SWL4 A0A8C0SWL4_CANLF Endothelin-1 (Preproendothelin-1) EDN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of vasoconstriction [GO:0019229]; vasoconstriction [GO:0042310] extracellular region [GO:0005576] MPSCSGDSGFKIHRTCIRFPSS 1 9.9 0.97344 0.046862 0 0 0 0 0 10.3651 0 0 0 0 0 0 0 0 0 A0A8C0SWL5 A0A8C0SWL5_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Complex I-B18) (NADH-ubiquinone oxidoreductase B18 subunit) NDUFB7 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747] NADH dehydrogenase (ubiquinone) activity [GO:0008137] DPKRMPTFPADYGF;LIRLLKCKR 2 16.8 0.99773 -0.59988 0 0 0 0 0 0 0 0 9.32868 0 0 0 0 0 0 A0A8C0SWL7 A0A8C0SWL7_CANLF SLX9 ribosome biosis factor SLX9 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" "90S preribosome [GO:0030686]; nucleolus [GO:0005730]; preribosome, small subunit precursor [GO:0030688]" GYLPQALGEELACSP 1 7.3 0.93632 0.066268 0 0 0 0 5.95413 0 0 0 0 0 0 0 0 0 0 A0A8C0SWM0 A0A8C0SWM0_CANLF Coiled-coil domain containing 134 SREBF2 Canis lupus familiaris (Dog) (Canis familiaris) FEVKRREQLLALKNLA;ILSLMAQELGI 2 11.8 0.98324 -0.25234 0 0 0 0 0 4.36786 0 0 0 0 0 0 0 0 0 A0A8C0SWM1 A0A8C0SWM1_CANLF Growth factor receptor bound protein 10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FSGQTGRVIENPAEAQSA;GLEESSVFSL;TVTGSWFSP 3 6.1 1.0036 -1.0639 0 0 0 8.48188 0 0 7.78313 0 0 0 0 0 0 0 0 A0A8C0SWQ3 A0A8C0SWQ3_CANLF Gamma-tubulin complex component TUBGCP4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasm [GO:0005737]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011] GYPGSIFTWNK;ILCSPISPSIHLHGNHVILDL;LQAQVSIHLMN;TEEDEEDL;VKWRLRNHMAF 5 7.7 1.0022 -1.7962 0 9.05951 9.05096 0 0 0 0 0 0 0 8.8728 0 0 7.98242 0 A0A8C0SWQ7 A0A8C0SWQ7_CANLF Spectrin repeat containing nuclear envelope protein 1 SYNE1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; nuclear migration [GO:0007097]; nucleus organization [GO:0006997] cytoskeleton [GO:0005856]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779]; kinesin binding [GO:0019894] AFEVWLGQEQENL;AKLKQNVHAH;AMGAHKKLSEPLEVSF;ASAQKVANRGSCVQEAAA;ATVTECESRMVQSIDFQTEL;AVFQATSQIQQHERKIMFREH;CDACATDAECDS;DLSTIQERMEEL;DTEMQALRADWK;EKPDVLSQELGMEG;ELLQRQWEELCHQLSL;ELQSIQALQNEVV;EPKTEDLKSQLNELCRFSRDLSTY;FFRNLPHWI;GKRQLLEEKLNDQ;GVLYTVAKEE;HCKVNDLKE;HDQIQDKVREVEQSKAMSQEFSRQI;IILKRVTVH;IIQDSHAQ;IQERMEELKGQMLKFSSMVP;ISKWNDYLEWR;ITELEESAQSFAQFVTT;KLQIEQPSMQEL;LEDIEQRV;LEWRNQLEQ;LTVLEHEAQSSAV;MLQDGATKSPGEEP;NEMLEFIL;NSVKSWVQETKEYLGN;QEKWKSASVRLEEQ;QELEMVRDHLNAF;QKFEENLRKIQKSVSEFEDKL;QKIAKDLTT;QKYQQVDEWLKTLENKVKVRT;QSVYDTVLQKCSH;QVGVLDYETFTKSLE;QWISEYQEILHTPEEPKMELYEKK;RLIDRIALYQH;RQDWQAYQQRLTETRTQFNNVV;RQLLEEKLNDQLEEQ;SADELDTSGSV;SEQEFSGQVAQ;SEQNGQLGKP;SLLDHFQSIVSEAEDHAGALQ;SSVHAQSTLESVI;TDKEIVECWQK;TKEKLRSCQVALQEHE;TQFHTELMAQASAV;VEATNSMNRKQ;VEECRTELDRETKL;VHAQSTLESVISKWNDYLEW;VHLEDLVPHLDPLA;VIANWDRYGNTVASLQ;VLEEINCYEPQ;WKDLQGEAPYHL 56 8.5 0.99678 -8.4727 10.2718 11.0917 12.3502 11.9199 10.7215 11.7344 10.8408 12.5119 12.4955 9.97571 11.405 10.2846 11.6081 10.9674 10.6333 A0A8C0SWR4 A0A8C0SWR4_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] AFLGLQLVKRLHINNNKI;GTFNAMPKLRILI;LTSIIQIDLHGNPWECS;PKLRILIL;SLPAPPAQEETFAPGPLPTPFK 5 12.1 1.0016 -1.2852 0 0 7.8813 0 0 0 0 6.0104 7.657 0 0 0 0 0 6.61335 A0A8C0SWT6 A0A8C0SWT6_CANLF PurE domain-containing protein CRACD Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' IMP biosynthetic process [GO:0006189] ATP binding [GO:0005524]; carboxy-lyase activity [GO:0016831]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639] ARRLMQFGIDRDWKQCRT;CSTILSPEGSAQFAAQIFG;EAAAPETDRKVEELRWQEVDERQT;EQEEGRHLEAQEQAVWRGQEAERQ;LGLSEEKRRADGPG;PETDRKVEELRWQEVD;QREEQLLLEEEQRRLEEEQREREEQ;QREEQQRLEEEQR;RKDSTECFYRQKTP;SQQKDKQSYRDLKEVTPEG;SVTERKDSTE;TPPSSPLA;TVRMAQDQGI;VEELRWQE 14 9.9 1.0024 -2.5822 4.75526 10.3811 9.94498 0 5.55514 0 4.10467 12.1607 10.192 9.56327 10.0657 4.22087 10.0407 11.615 0 A0A8C0SWW1 A0A8C0SWW1_CANLF DUF3456 domain-containing protein CNPY4 Canis lupus familiaris (Dog) (Canis familiaris) EVTFLKKQCETM 1 5 0.98442 -0.23795 10.8254 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SWY3 A0A8C0SWY3_CANLF Calponin-homology (CH) domain-containing protein FNTA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705] cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] AAKDDYRIRCEELE;DPAYFDENWLNRIK;EKLIRLQHEN;FTLPDVNL;SVERVELCESL;SVERVELCESLLT 6 8.7 1.0032 -1.0321 10.904 10.8894 10.1787 0 9.55032 0 11.711 0 11.145 0 0 0 10.0366 10.6311 6.52218 A0A8C0SX00 A0A8C0SX00_CANLF Prostate and testis expressed 1 Canis lupus familiaris (Dog) (Canis familiaris) NSGDHKLQS 1 7.3 1.0034 -0.80421 0 0 0 0 0 0 9.29216 0 0 0 0 0 0 0 0 A0A8C0SX05 A0A8C0SX05_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] FKLNTKETNNPIMKWAKDM;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;SEVSQSVKDKHY 5 5.1 0.94214 0.10046 0 0 0 0 0 0 9.03524 0 0 0 0 0 0 0 7.19908 A0A8C0SX10 A0A8C0SX10_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] ISNIKSEDEDDYYYC;YYCGSYDSSGNCP;YYCGSYDSSGNCPNF 3 19.9 0.991 -0.27309 0 0 0 0 0 0 0 0 0 0 0 0 4.31332 0 0 A0A8C0SX24 A0A8C0SX24_CANLF Ig-like domain-containing protein NPTN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LAEIIILVVIIV;TRKNASNMEYRINKPRAEDSGEY;VGSPTPEIQWW 3 10.2 0.9905 -0.53451 10.5371 0 0 0 0 0 4.29477 0 0 0 0 0 0 0 0 A0A8C0SX42 A0A8C0SX42_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP1A4 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium transmembrane transporter activity [GO:0008556] EDSPQSHVLVMKGAPE;EEVVVGDLVEVKGGD;ETRNICFFSTNCVEG;FLGVSFFVLS;VSEGVAAHTGPGGVRTGQGR 5 8.2 0.94825 0.050068 0 0 0 0 0 0 0 0 0 0 0 0 7.74698 0 0 A0A8C0SX46 A0A8C0SX46_CANLF High mobility group box 1 HMGB1 Canis lupus familiaris (Dog) (Canis familiaris) DNA metabolic process [GO:0006259]; innate immune response [GO:0045087]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleus [GO:0005634] "DNA binding, bending [GO:0008301]" LKRARKRRKRRKTRRMKRMRRRKK;LMRQKRELSRLKRARKRRKRRKTRR;LSRLKRARKRRKRR;SLMRQKRELSRLKRARKR 4 14.6 0.99283 -0.14394 0 9.99944 5.16985 0 4.52707 5.75304 0 0 0 0 0 0 0 0 3.7536 A0A8C0SX61 A0A8C0SX61_CANLF Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) USP11 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; ubiquitin-dependent protein catabolic process [GO:0006511] mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; ubiquitin activating enzyme activity [GO:0004839] EVPTRAAPGEP;FQVVVLTNTPLEDQLRVGE;GKNRAEVSQPRLAE;KMYPIDFEKDDD;SSPLEWGAPLEIVHED;VLGPYTFSIC;YVLGHEAMKRL 7 6.3 1.0021 -0.90668 9.03251 4.45615 6.3959 0 0 0 4.85903 12.6291 0 0 0 0 0 1.48264 9.0666 A0A8C0SX87 A0A8C0SX87_CANLF UBC core domain-containing protein BIRC6 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of cytokinesis [GO:0032465] ubiquitin-protein transferase activity [GO:0004842] DESLLETCPIQSPLQ;DIQKTAEIVHAATTS;EEMQHMDVEESQCL;FEFDVYFPQ;HYMSQVKNANDAN;LNIEVEQNGKPSLV;LNYVKDEDLAGCSTACA;LSLNSSSSGNK;NIPQIQVTL;PATSPISSNSHRS;PEEKWNPQTSSFLQ;SCPEDEALTPSDECMDGI;SLDRLYSRKIRKQLVHHKQQLNLLK;SLLAKVAA;TQEKPKDSDQ;TSQKEAMEVSLDIT;TSVGTLLA 17 4.9 0.99865 -3.0226 12.357 12.5248 8.067 9.85106 0 9.27368 8.90123 12.8036 12.0113 0 12.9684 12.6079 12.1672 12.312 12.1188 A0A8C0SX89 A0A8C0SX89_CANLF Laminin subunit beta 3 Canis lupus familiaris (Dog) (Canis familiaris) GVCPGELC;LQDILMDFKGPMPAG;VQSDAQRLETQVSTSRS 3 3.5 0.99406 -0.16447 0 0 8.11577 8.35036 8.37998 8.7451 0 0 0 0 0 0 0 0 9.72923 A0A8C0SXA1 A0A8C0SXA1_CANLF "Adiponectin, C1Q and collagen domain containing" ADIPOQ Canis lupus familiaris (Dog) (Canis familiaris) brown fat cell differentiation [GO:0050873]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; detection of oxidative stress [GO:0070994]; fatty acid beta-oxidation [GO:0006635]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of blood pressure [GO:0045776]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular protein transport [GO:0090317]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of metanephric mesenchymal cell migration [GO:2000590]; negative regulation of phagocytosis [GO:0050765]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of synaptic transmission [GO:0050805]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of glucose import [GO:0046326]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of metanephric podocyte development [GO:2000478]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myeloid cell apoptotic process [GO:0033034]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of renal albumin absorption [GO:2000534]; protein localization to plasma membrane [GO:0072659]; response to bacterium [GO:0009617]; response to glucose [GO:0009749]; response to tumor necrosis factor [GO:0034612] cell surface [GO:0009986]; collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activator activity [GO:0043539]; sialic acid binding [GO:0033691] ETGVTGVEGPRGF;FTKIFYNL;GVTGVEGPRGF;LLRAVLLL;PGLRMLLLRAVLLLLVLPA;TGETGVTGVEGPRGF;TVPNVPIRFTKIFYN 7 19.8 1.0024 -1.1673 0 0 9.98114 0 0 8.252 0 0 10.3523 3.24362 0 0 9.2105 0 7.35473 A0A8C0SXD7 A0A8C0SXD7_CANLF Tyrosine-protein kinase (EC 2.7.10.2) BTK Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; intracellular signal transduction [GO:0035556]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] DKNGWYSKHM;FQTQQLLEMCKDVCEAMEYL;ITEYMANG;WSPPEVLMY 4 7.1 0.99295 -0.27132 0 0 0 0 0 0 0 0 0 0 0 0 8.61298 0 0 A0A8C0SXE5 A0A8C0SXE5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; zinc ion binding [GO:0008270] CTFMSESG;LCVDTDISFLFFFNFYLF;LHAVFHIPSQDARHKALNTCGSHIC 3 6.7 1.0023 -1.0205 0 0 0 4.33985 0 0 0 0 0 0 0 5.2021 0 7.63648 7.43279 A0A8C0SXF8 A0A8C0SXF8_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] CESSLQESKQRKDLQDLFS;EPSEAPLSSSSLS;GKPVLRISSDPP;IDLENIVYYKDC;KFCAGSIDH;LDPLDHRNFY;LLCAENVN;PQTARETPPALGKAQE;PSVVVTGHVLRELKQVSAGGE;SQQRKRRAELKQQREEEGTWKEQE;VGQDMMAVCVL;VLEPPEDQENQK 12 8.6 1.0012 -2.6939 0 9.49073 0 0 5.97675 0 9.96074 0 12.3717 6.23172 10.2897 0 10.6642 0 10.4312 A0A8C0SXH1 A0A8C0SXH1_CANLF Fms related receptor tyrosine kinase 3 ligand Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine activity [GO:0005125] AGGGQSGH;DGRHEGRE;LLLLLLLP;PAPQAPRLLLLLLLPVALLL;RLLLLLLL 5 7.2 1.0018 -1.3179 0 0 0 0 0 0 0 9.07315 0 0 0 9.21931 0 5.62912 0 A0A8C0SXH3 A0A8C0SXH3_CANLF Ovochymase 2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EDGGLARYLQ;GEEACPHCWPWQVG;PGGLTEKMMCAGF;PSTDNAFGPGCYSEV;VTGWGSISEDGGLARYLQ 5 12.5 0.98564 -0.44292 0 0 10.2101 0 0 0 8.70411 0 0 0 0 0 9.77383 0 0 A0A8C0SXH8 A0A8C0SXH8_CANLF SEFIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] GGAAGGGA;RPPPPPPPSAPGGGAAGGGA;SYSCVRCNYTEAFQT;VLCRRRGP;VSSSCDNTCGQREGSPHESSQ 5 8 1.0011 -0.95074 0 0 0 0 0 0 0 7.07221 9.224 0 0 10.1548 0 6.1313 9.56398 A0A8C0SXI2 A0A8C0SXI2_CANLF snRNA-activating protein complex subunit 3 (Small nuclear RNA-activating complex polypeptide 3) SNAPC3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EFLAYPYVDP;GRQDPVSSSGSCNFPEYE;PDVVPENTDLVTLGV;TDMIEEGELILSVNILY 4 10.1 1.0039 -1.0588 0 0 0 0 0 0 0 0 0 0 0 9.65206 11.227 7.62826 0 A0A8C0SXJ0 A0A8C0SXJ0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KQKESWLEPLSIVEI;VHLKVIPP 2 5.7 0.95158 0.053889 0 0 10.0011 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SXK4 A0A8C0SXK4_CANLF Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Ribophorin-2) RPN2 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] oligosaccharyltransferase complex [GO:0008250] GSCPHKMNKIKGKNSTLVP;LDRPFTSLESAFYS;VFELNFMN;VIQLMNAIFSKKNFESLSEA 4 9.1 1.0027 -1.5074 0 9.11824 0 0 8.84596 9.11296 0 0 0 0 0 0 8.88689 0 0 A0A8C0SXM1 A0A8C0SXM1_CANLF Histone deacetylase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LVLVSAGFDSAIGDPEGQM;QLEAQWKMLQVAPG 2 4.6 0.85021 0.14863 0 0 0 0 9.46465 0 0 0 0 0 0 9.01025 0 0 0 A0A8C0SXM9 A0A8C0SXM9_CANLF Phosphorylase b kinase regulatory subunit PHKA2 Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] plasma membrane [GO:0005886] calmodulin binding [GO:0005516] DLGGYLEDTYNQVTEG;INHLLQSTSLKCYLPPL;LDEVAFIQNLVFY;LPSSTTREMTPQE;LRLRIGLIIQ 5 5.2 1.0037 -0.81263 0 0 0 0 0 0 0 9.03922 0 0 0 9.91412 2.6397 9.44613 10.0637 A0A8C0SXS0 A0A8C0SXS0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAPLLPKKGILKK;AGDVFMSADSEEQK;KQAVKRHHHKHNLRHRY;LERQHSLKKSR;LKLPKSILKKKA;LLDAGDVFMSADSEEQKPP;LPKKGILKKPRQ;YASPEIVNGKPYTGP 8 14.8 0.94869 0.081336 0 4.71397 0 9.39592 0 2.42538 4.94219 0 0 7.79259 0 0 6.44649 7.19495 0 A0A8C0SXS2 A0A8C0SXS2_CANLF palmitoyl-protein hydrolase (EC 3.1.2.22) DESI1 Canis lupus familiaris (Dog) (Canis familiaris) peptidase activity [GO:0008233] LSSLGESLFR 1 6 0.99107 -0.13433 0 0 0 0 0 11.0327 0 0 0 0 0 0 0 0 0 A0A8C0SXV0 A0A8C0SXV0_CANLF Sodium/glucose cotransporter 1-like Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FPWPGMSLASL;LGSILVMGFAFQE;TITGTSLFTD 3 7.2 1.0008 -0.63544 0 10.1747 0 8.99042 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SXV9 A0A8C0SXV9_CANLF Zinc finger and SCAN domain containing 21 ZSCAN21 LOC119863904 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] KCEGWEPLYIQETGEEQNFT 1 4.3 0.97372 0.048206 0 0 0 0 0 0 0 0 8.0908 0 0 0 0 0 0 A0A8C0SXX6 A0A8C0SXX6_CANLF UEV domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211]; protein transport [GO:0015031] endosome [GO:0005768] ESQLKKTVSKYKYRDL 1 17 0.96228 0.049233 0 0 0 0 0 5.39818 0 0 0 0 0 0 0 0 0 A0A8C0SXZ2 A0A8C0SXZ2_CANLF Protein-tyrosine-phosphatase PTPRA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] KIYNKIPG;TIEDFWRMIWEWKSCSIV;VIDAMLDMMHTE 3 5.3 0.99383 -0.15949 7.66931 0 10.216 0 0 0 0 0 8.17847 0 5.97437 0 0 0 0 A0A8C0SXZ9 A0A8C0SXZ9_CANLF VWFA domain-containing protein VWA3B Canis lupus familiaris (Dog) (Canis familiaris) AQGLGVSSH;FPHCEDYVTSLGRLV;IYQFVEHLTRAVESYKQRMDW;LETLSREG;LVVSKVFDE;PTKKTKSKKL 6 5.6 1.0033 -1.6935 0 0 0 9.06331 0 0 7.31985 3.23779 0 0 0 0 6.87774 0 7.13494 A0A8C0SY12 A0A8C0SY12_CANLF Growth factor receptor bound protein 10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FSGQTGRVIENPAEAQSA;GLEESSVFSL;PADRLTGH 3 6.6 1.0044 -1.1044 0 0 0 0 0 0 0 0 5.32675 0 0 0 0 0 0 A0A8C0SY17 A0A8C0SY17_CANLF Keratin-associated protein 12-1-like Canis lupus familiaris (Dog) (Canis familiaris) YVVPSSQSSVCLPVS 1 13.6 0.98192 -0.2487 0 0 0 0 9.70231 0 0 0 0 0 0 0 0 0 0 A0A8C0SY18 A0A8C0SY18_CANLF 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] membrane [GO:0016020] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" DIRHLSDVEKAFQ 1 3.3 0.9442 0.05964 9.00259 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SY21 A0A8C0SY21_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DGAQRAAELPQPQPLPPRRRAPPG;HVDSEDEDEASEDGCLE;LLECLEFDPE;QELSLAPAPAAGQV;SPLAHTPS;STESVDEEGRQSPA;SYFDTRSERYQ 7 5.6 0.99244 0.0050839 0 10.8322 0 7.76799 8.11385 0 0 0 0 0 0 0 6.10951 0 0 A0A8C0SY49 A0A8C0SY49_CANLF K Homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468]; regulation of RNA metabolic process [GO:0051252] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729]; single-stranded DNA binding [GO:0003697] STERAITIAGIPQSII 1 5.2 0.95611 0.049233 0 6.94451 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SY54 A0A8C0SY54_CANLF "Prostate transmembrane protein, androgen induced 1" Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901] R-SMAD binding [GO:0070412] HAHIAPLESTA;IMVVVMVMVVVITCLLSHYKLSAR;PTYPYLQHQIDLPPTISLSDG;SLSDGEEPPPYQ 4 25 0.8664 0.18059 0 0 0 0 0 0 0 0 0 0 8.73853 0 0 11.8242 0 A0A8C0SY74 A0A8C0SY74_CANLF Olfactory receptor family 52 subfamily E member 8 OR52E8C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVRTKQIRERVLRV;ISLLLLDVLLIILSYVRILHAVF;IVLVAMAFDCYIAI;LLLDVLLIILSYV 4 15.9 0.72892 0.25271 0 7.56476 0 0 6.47774 0 0 3.48864 0 0 0 0 0 0 0 A0A8C0SYA5 A0A8C0SYA5_CANLF Zinc finger protein 157 ZNF157 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GKVFYKKT;GQSGRSFEVSVSFEDVAVDFTR 2 5.9 1.0022 -1.3623 0 6.95745 0 0 0 0 0 8.3415 0 0 0 0 0 0 0 A0A8C0SYC0 A0A8C0SYC0_CANLF Phosphatase and actin regulator PHACTR1 Canis lupus familiaris (Dog) (Canis familiaris) cell motility [GO:0048870]; stress fiber assembly [GO:0043149] nucleus [GO:0005634]; synapse [GO:0045202] actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] LKQPPALPP;PSAKPVLLL;PVLLLPPKKP;TEMEVHELSRHL;TSADGELSISNE;VPCSTSYHSSGLHSSDGV 6 12.3 1.0028 -1.1226 0 10.5031 8.22733 0 0 0 0 0 11.3094 0 0 0 0 3.4098 0 A0A8C0SYF0 A0A8C0SYF0_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] AGLSFAFP;DIDHVRTNTNKSL;PSLATSQLSQKSRCPGCYQ;TLIKYQEVVEEL;TREDDNDDGDDYEN 5 17.3 1.0032 -1.5195 0 0 0 0 0 0 11.6655 0 11.7119 0 11.9337 10.602 0 0 11.1089 A0A8C0SYF6 A0A8C0SYF6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;EASPCCQQSSCQPSC;ETCCEPPCCAPASCL;PCCQQSSCQPSCCNSSPCQEGCC;PSCCNSSPCQEGCCVSVCC;PSSCQPSC;QPSCCNSSPCQEGCC;QPSPCRPS;SCGSCSPCQEGCCM;SDVRMALTSREDT;SPCQEGCCMSVCC 13 39.9 1.0032 -2.452 0 8.3427 0 6.48564 0 0 0 7.92101 0 0 0 0 0 0 0 A0A8C0SYG3 A0A8C0SYG3_CANLF Sodium channel protein Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] ETMWDCMEVAGQAMCL;FTEACVQRCPF;IDDFTFLRD;IVEEEARQQRNKQMEIEDPER;RVIRLARIGRVL;SEPEDGKKPPQPLDGNSS;VEHNWFET;VLRSFRLLRVFKLAKSWPTLN;YGNDTWYSNDTW 9 7 1.0031 -0.88856 0 0 0 8.70463 0 0 0 0 7.33262 7.09582 0 9.67396 0 6.68636 8.48567 A0A8C0SYG7 A0A8C0SYG7_CANLF maleylacetoacetate isomerase (EC 5.2.1.2) GSTZ1 Canis lupus familiaris (Dog) (Canis familiaris) L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] cytoplasm [GO:0005737] catalytic activity [GO:0003824] RAYVHMIS 1 5 1.0033 -1.1044 0 0 10.5201 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SYH0 A0A8C0SYH0_CANLF GRIP domain-containing protein TRIP11 Canis lupus familiaris (Dog) (Canis familiaris) AESLGMDKRD;EQKKEMDEFKCQHEQM;EVEAELPN;EVGHWRHIAQTSKAQG;KQMENSALQNEVQH;LGPGGPGH;LSRIIREKD;QKCQTLLTVLQTSSTGNE;SLNENFTNKVNENELLRQA;SPDNSAGV;VLQTSSTG 11 6.6 0.99732 -3.5678 8.76967 9.28142 9.71769 0 0 8.88756 7.71699 13.1485 13.9284 0 0 0 0 9.54084 0 A0A8C0SYH5 A0A8C0SYH5_CANLF Calsequestrin Canis lupus familiaris (Dog) (Canis familiaris) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014809] sarcoplasmic reticulum lumen [GO:0033018]; Z disc [GO:0030018] calcium ion binding [GO:0005509] AGEINTEDDDEEEDDDDDD;EFSADTLV;GVLAGEINTEDDDEEEDDDDDD;NTEDDDEEEDDDDD;PLALLLLLVLGPPRLGVQGEE;VLAGEINTEDDDEEEDDDDDD 6 13.6 0.97282 0.046699 0 0 0 0 0 0 8.47098 0 0 0 0 0 0 0 0 A0A8C0SYH7 A0A8C0SYH7_CANLF HYDIN axonemal central pair apparatus protein HYDIN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ANLLNILQTIESGG;APELNLGARFSLDTY;DPNQSQMEFQEP;DQALFQPF;EASLVNYSF;EASLVNYSFDTK;EIMFSFSVDSLGIL;ELSTTMGSG;FARNAATALLCLLKAIGNREH;FSIISYPM;GVCVGPPA;IINFYEVE;KKCVLKGLELRI;KVVFPQRKLDMKLN;LDKSHINFSC;LEFNWVSEDTAKA;LNVWAYPTAAG;LYTNTAHLE;MCVASRSHA;NEITLKNTGK;NREVQQALRERKKRE;RGPSGAALDSNTRV;RKDRERERAEKERAEKERQEREKAE;SFQIQIAHLDPENITLHGE;SHSKRLFV;SPLPLTPEPIKLE;TEEEKVTFNREVQ;TSNVHFKETLVYQTR;TTSYIYITEENKPH;VGEVENNP;YPGFGSIPSGGIQ 31 7.2 0.99697 -6.8857 12.324 0 10.7418 11.1643 0 11.1422 10.6323 11.3685 10.187 8.42982 8.04297 10.3901 15.9537 12.4678 12.5655 A0A8C0SYI1 A0A8C0SYI1_CANLF Prostate and testis expressed 2 Canis lupus familiaris (Dog) (Canis familiaris) RLLQLLLLGILTLV;VLRLLQLLLLGI;VLRLLQLLLLGILT;VLRLLQLLLLGILTLVFMKEGIR 4 16.9 0.97836 0.046253 0 0 0 0 0 0 0 0 5.26577 0 0 0 0 0 0 A0A8C0SYL8 A0A8C0SYL8_CANLF Family with sequence similarity 216 member B FAM216B Canis lupus familiaris (Dog) (Canis familiaris) SRPQWEALQNRYIHSLQHQ 1 13.7 0.95325 0.049538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.8515 A0A8C0SYM0 A0A8C0SYM0_CANLF Endoplasmic reticulum-Golgi intermediate compartment protein ERGIC2 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] GVSGIFMKYDLSSLMV;QDTWMKYEYEVDKDFSSKLRI 2 10.8 0.9326 0.096906 0 0 0 0 5.96343 9.62269 0 0 0 0 0 0 0 0 0 A0A8C0SYM7 A0A8C0SYM7_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] GGFGRVSLGGACGAGG;GGGAGFGG;GSGLGGGSGYSYGS;LTDEINFTRA;TSVSRSGGGGGGFG;VGGGFSSS 6 11.5 0.99904 -3.2272 0 0 10.3577 0 4.61306 10.3222 10.8737 0 12.5016 0 9.44611 0 0 0 4.73871 A0A8C0SYN3 A0A8C0SYN3_CANLF Thrombospondin-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] DDILASPPRLLD;GHKGEIGFPGRP;GLPGVKGDPGIVGPPGA;GSAGQGCP;PGPPGPPGTM;VPEGWLMFVAEREE 6 5.6 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.77386 A0A8C0SYP3 A0A8C0SYP3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VGCPRGLPVQ 1 9.5 0.99119 -0.26939 0 0 0 0 0 0 0 8.08619 0 0 0 0 0 0 0 A0A8C0SYR4 A0A8C0SYR4_CANLF Association with the SNF1 complex (ASC) domain-containing protein PRKAB1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] protein kinase binding [GO:0019901] LNKDTGISCDPALLPEPNHVML;RFKAPPILPPHLLQVI 2 36.5 0.99207 -0.20824 0 0 0 0 0 8.74191 0 0 0 0 0 0 0 7.71122 0 A0A8C0SYS5 A0A8C0SYS5_CANLF Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) PPP1R1A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase inhibitor activity [GO:0004864] QGAGTLRDEACALLPGGF;TREAQERGREKPG 2 7.2 0.97393 0.048313 0 0 0 0 0 7.67363 0 0 0 0 0 0 0 0 0 A0A8C0SYS6 A0A8C0SYS6_CANLF "SDS3 homolog, SIN3A corepressor complex component" Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] Sin3-type complex [GO:0070822] histone deacetylase binding [GO:0042826] KERIRNAELF;KRLFTIRPKLQ 2 4.6 0.98303 0.035491 0 0 0 0 0 0 0 0 0 0 3.59682 0 0 0 0 A0A8C0SYT3 A0A8C0SYT3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;GVLPNSFYEASIALIPKPDK;MDAFLESHKL;NTLILCDFNLA;PSICCLQETHFRQ 5 6.9 0.98536 -0.23727 0 0 7.98806 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SYT5 A0A8C0SYT5_CANLF VWFA domain-containing protein CACNA2D3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] calcium channel activity [GO:0005262] AGDKENIFNADHF;NILSDFNHTGQG;PGSFVYSIPFSTGI;VEGAVMNK 4 4.3 1.0026 -1.8522 0 0 0 15.3499 10.0336 0 0 0 0 9.07031 6.43443 0 0 0 0 A0A8C0SYV5 A0A8C0SYV5_CANLF ferroxidase (EC 1.16.3.1) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491]; signaling receptor activity [GO:0038023] IMFTLVDENQSW;LIHCHVSDHIHAGMETTYTVLRNID;LPSDPVREPLPQAVF;TDVDREFIIMFTLVDENQ;VGPLLVCK;VVENPGKWMITCQ 6 6.8 0.95049 0.053897 0 0 0 0 0 5.83018 0 0 0 0 0 0 0 0 0 A0A8C0SYX5 A0A8C0SYX5_CANLF Dual specificity phosphatase 22 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] protein tyrosine phosphatase activity [GO:0004725] MCAVMHMSPP 1 6 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 8.91618 0 0 A0A8C0SYY8 A0A8C0SYY8_CANLF Beta-galactosidase (EC 3.2.1.23) LOC606786 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] beta-galactosidase activity [GO:0004565] DQGINQVIVFEERMAGPAI;GVLLLLLLGLLVLRRLDWYRLV;LLLLLLGLLVLRR;QVENEYGSYNKDPAYMPYI;TLARKPGRTLGVLLLLLLGLLVL;TSYDYDAV 6 12.9 0.99627 -0.013835 0 0 0 14.8801 0 14.9557 7.68825 8.40143 6.60173 0 0 4.41643 10.0934 0 0 A0A8C0SYZ4 A0A8C0SYZ4_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HQLEDTASIFSLKEIQLQKDPG;RGWFPYLRPRLPP;SLPMDIRLPQ 3 8.1 0.9966 -0.5744 0 0 0 9.13034 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SYZ9 A0A8C0SYZ9_CANLF Coiled-coil domain containing 180 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] CHRLEKEA;DILVSSEALEEEAKLDLVTPESFA;EAEKKEEEEEEE;ESPKQKTSILIRRKLARL;GRVSRPAAKVKM;VIIPPRLVLQIK;VIIPPRLVLQIKRQL;VRQQKWAHSLP;WHSALSILNKNLDNYHMDCMMRIRL 9 7.3 1.002 -1.2345 5.15838 5.27564 0 7.3505 8.59746 0 0 10.2628 8.0162 9.54655 7.3497 0 10.3058 0 10.5139 A0A8C0SZ03 A0A8C0SZ03_CANLF DUF1907 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EYSFHVPSLEE;IEKGKAKT;LGAGAGPF 3 10.5 1.0034 -1.5447 0 12.2951 0 0 0 0 0 0 0 0 8.69519 9.40303 0 0 0 A0A8C0SZ11 A0A8C0SZ11_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IFLSYALILHSVLKL;LCSNLGVTRLSCDDRTINSIYQLF;LILIIIKQ;LILIIIKQEILAILWF;LSYALILH;VISITHSATMTLPLIPVLLNVL 6 26.5 0.96204 0.049233 0 0 4.30181 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SZ20 A0A8C0SZ20_CANLF GST C-terminal domain-containing protein GDAP1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626] membrane [GO:0016020] EFLSVPGLAYLR;LDTTTGPWH 2 5.8 0.99001 -0.26347 0 0 0 0 0 0 0 10.9557 0 0 0 0 0 0 0 A0A8C0SZ51 A0A8C0SZ51_CANLF "Isocitrate dehydrogenase [NAD] subunit, mitochondrial" IDH3B Canis lupus familiaris (Dog) (Canis familiaris) isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] "magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" IADAVKKVIKVGKVR;MIADAVKKVIKVGKVRT;NPGAWRNLGTSAVAHAASRSQAEDM;VLSSMKENK 4 13.3 1.0026 -1.1901 0 0 0 0 0 0 0 10.5745 0 0 0 0 0 0 0 A0A8C0SZ71 A0A8C0SZ71_CANLF Rho guanine nucleotide exchange factor 26 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] GERGWFPME;PCQSPGGP;VLIYQRVGD 3 3.3 1.0032 -2.1484 0 0 9.07213 0 0 0 0 0 0 8.70183 0 0 7.1235 9.35933 0 A0A8C0SZ75 A0A8C0SZ75_CANLF Ubiquilin 3 LOC102152113 Canis lupus familiaris (Dog) (Canis familiaris) HYDTDRLVL;LEHLKAMGFANHDANLQ 2 5.3 0.99023 -0.31422 0 0 0 0 10.4234 0 0 0 0 0 0 0 0 0 0 A0A8C0SZ94 A0A8C0SZ94_CANLF Centrosomal protein 135 CEP135 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EEAHVMKKTIDV;IDQLAQQLERHKE;KLKLLEKESKAKNERI;KLKSLQEMSIF;KLREQSSQHIKE;LDRGRSPDI;QELTEIDQLAQQ;TLSESKLERAIQ 8 8.1 1.0018 -1.4135 8.07286 0 0 0 0 8.6291 0 0 6.60585 11.8279 11.6054 0 0 4.54677 0 A0A8C0SZD0 A0A8C0SZD0_CANLF "RAB36, member RAS oncogene family" Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] GTP binding [GO:0005525]; GTPase activity [GO:0003924] RMEESPPETQEST;VSRDRIITSFPK 2 7.5 0.99283 -0.17188 0 0 0 0 0 0 0 0 9.513 0 0 8.64469 0 0 0 A0A8C0SZD7 A0A8C0SZD7_CANLF Solute carrier family 22 member 6 (Organic anion transporter 1) (Renal organic anion transporter 1) SLC22A6 Canis lupus familiaris (Dog) (Canis familiaris) renal tubular secretion [GO:0097254] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; prostaglandin transmembrane transporter activity [GO:0015132]; solute:inorganic anion antiporter activity [GO:0005452]; xenobiotic transmembrane transporter activity [GO:0042910] MTAELYPSVPLFIY;TSFAYYGLVM;VGGVGRFQQIQVTLVVLPLL 3 8 1.0026 -1.1622 0 0 0 0 0 0 0 0 0 0 0 2.64279 9.01223 8.97163 0 A0A8C0SZE6 A0A8C0SZE6_CANLF Protein kinase domain-containing protein TESK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ADFGLAEKIPD;LEQLLDSNL;PQQGGAAHTPKVNPFSARQDLKGG;TSKNCLIKR;VPFCVSGMGLKTQ 5 12.8 0.98701 -0.38015 7.25918 13.1571 0 0 0 0 7.4957 0 13.5919 0 0 9.60674 0 0 0 A0A8C0SZF8 A0A8C0SZF8_CANLF Cohesin subunit SA (SCC3 homolog) (Stromal antigen) STAG2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; nucleus [GO:0005634]" chromatin binding [GO:0003682] AEMFRHMQNSEIIRKMTEE;EACSKTYHALCNEE;LFSRRDPEEDG;TVVEMNTAADIFKQ;YSIIYDEYMMD 5 6.1 1.0045 -1.0481 6.81224 7.22168 0 0 0 0 0 11.1456 0 7.96942 0 0 0 0 0 A0A8C0SZG5 A0A8C0SZG5_CANLF "Keratin, type II cytoskeletal 7 (Cytokeratin-7) (Keratin-7) (Type-II keratin Kb7)" KRT86 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] EFVVLKKD;FQQVRREEREQ;SLACLCVGGSGGWDPHDCKY 3 9.1 0.99203 -0.54991 0 0 0 0 0 0 0 0 0 13.4522 0 0 0 0 0 A0A8C0SZH3 A0A8C0SZH3_CANLF Establishment of sister chromatid cohesion N-acetyltransferase 2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] acyltransferase activity [GO:0016746]; metal ion binding [GO:0046872] LIAEPIKQ;TEKIQGKPVCSKRMIKRPQ;TVSFYKKDKWYLNPLE 3 7.4 0.98617 -0.41192 0 5.23997 0 0 0 0 0 0 0 0 0 0 7.86282 0 0 A0A8C0SZH6 A0A8C0SZH6_CANLF IPT/TIG domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAAAAAAAAGWPGPA 1 1.4 0.93441 0.067452 0 0 0 8.12985 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SZI0 A0A8C0SZI0_CANLF Sulfhydryl oxidase (EC 1.8.3.2) QSOX2 Canis lupus familiaris (Dog) (Canis familiaris) flavin-dependent sulfhydryl oxidase activity [GO:0016971] AFTKDFTTGENFKGPDRELQTVRRT;GGHQSCGP;HRSTFGKTAPPCFNN;VRKKLISLPEKP 4 8.9 1.0018 -0.96451 5.62621 0 0 0 0 0 0 10.4385 0 0 0 0 0 6.23423 7.31288 A0A8C0SZJ0 A0A8C0SZJ0_CANLF Cyclic GMP-AMP synthase CGAS Canis lupus familiaris (Dog) (Canis familiaris) DCLKLMKYLLEQ;KTAFFHVCTQ;LESKSSWP;SPAITLLI 4 7.4 1.0022 -1.8627 0 0 3.90977 0 0 0 0 0 0 0 0 0 0 8.37908 0 A0A8C0SZK5 A0A8C0SZK5_CANLF Peptidase S1 domain-containing protein LOC100684662 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] AASLYSVVLL;NVMNQAASLYSVVL;VGPRRRPRRPPRRPPRR 3 6.5 0.98484 -0.44554 0 0 11.5825 0 0 0 0 0 0 0 0 7.20838 9.6474 0 0 A0A8C0SZK8 A0A8C0SZK8_CANLF Zinc finger protein 527 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CYSFFTQPQTIH;GEKPYACNDCGKAFSHD;GLSISKPNMISLL 3 7 0.98655 -0.459 0 0 0 0 11.9834 0 0 0 0 0 0 8.46728 10.5468 0 0 A0A8C0SZL0 A0A8C0SZL0_CANLF Peroxisomal membrane protein 2 PXMP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] LLLDRLLFAPAFLLLFFLIM;LRRALVQYLRLLRL;SSRMCRRGKGSLTCSDIR;VLPVPGPV 4 21.1 1.0029 -1.5111 0 0 0 0 0 0 0 0 0 0 10.0747 0 6.28324 10.326 0 A0A8C0SZM2 A0A8C0SZM2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVHLSTHT;GGGGGGGG;GPGLVITSPSGS;GVAGTATP;SGISMDTESKSDQL 5 10.5 1.0042 -1.1044 0 0 9.00203 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SZM7 A0A8C0SZM7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TSPCVTTLTSSDVPG 1 19 0.94874 0.055375 0 0 0 0 6.77584 0 0 0 0 0 0 0 0 0 0 A0A8C0SZP0 A0A8C0SZP0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] HFDPNGVLADGLGEEPL;NLNSKLERSQSC;SGQALSECAGPTPIDL;SISEELNHFKPIVCSPCT 4 8.9 0.99455 -0.56074 0 0 7.62899 0 0 8.09893 0 8.36159 0 0 8.71593 0 0 0 10.062 A0A8C0SZR2 A0A8C0SZR2_CANLF Myb-like domain-containing protein CRACD Canis lupus familiaris (Dog) (Canis familiaris) EAAAPETDRKVEELRWQEVDERQT;EEQATRCANVKTEEKQSGR;EQEEGRHLEAQEQAVWRGQEAERQ;LGLSEEKRRADGPG;PETDRKVEELRWQEVD;QREEQLLLEEEQRRLEEEQREREEQ;QREEQQRLEEEQR;TPPSSPLA;TVRMAQDQGI;VEELRWQE 10 10.9 0.95124 0.049629 8.39069 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0SZR9 A0A8C0SZR9_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Canis lupus familiaris (Dog) (Canis familiaris) diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] AAVTPAAA;GGAEHGGGV;GLRLFQKFDNFRIL;LDRWSIMTY;LVGRVPLQLESPHE;PPEASEEFYMT;PPGAAGGA;SYKNLEQRVQLE;VSPLLVFVN;WLYYILHPNED 10 6.4 0.99663 -4.8387 0 13.018 0 9.07028 0 0 13.5288 9.21473 10.5065 11.4658 0 0 0 0 0 A0A8C0SZS9 A0A8C0SZS9_CANLF CD109 molecule CD109 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] CGDDHGCSPCERGAAATP;EIESVQVINYTVPQ;ISDNYTLAL;KAFFLNSVSSMAVHGMFKSP;PIRPTYLGE;VTVMGPSSPS 6 5.8 1.0023 -1.3914 0 9.07253 4.51065 0 0 0 0 0 0 0 0 10.4568 10.4599 0 8.8333 A0A8C0SZU6 A0A8C0SZU6_CANLF Glutamate decarboxylase like 1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] SAVLVDGVILNGPT;VISPQVSREDMDFLLD;WYIPPSLSPPPSSHPM 3 10.4 0.99085 -0.27489 0 0 10.7011 8.64929 0 0 0 0 0 0 0 0 9.00935 0 9.84867 A0A8C0SZX7 A0A8C0SZX7_CANLF DUF4211 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAAYATGKASGAGGAG;AAKAPSTPPPKAAPPPPALTPDS;AEEEEEEEEEEEEEEEEEEQQPA;CGETDEEAGESGGEG;CPSPCKRLDEELKRNL;EETSWSGEER;EVAKAAPGSTKPKKTKVKAK;GAGGGGGG;GHGGGWGP;HRDGGGGGGKKKKKRSRSR;LDLRRKILTQ;LSTEERGGKSSE;PAGEPYNR;PLTSICFPDSL;PSPEEEEEEEEEEEEEE;TPSPEEEEEEEEEEEEEEEEEEEEE;TTATSTAAAAPSTAPSAGS;VLGPAGLGP 18 7.6 0.99728 -3.7791 0 11.0826 0 7.33727 10.6923 9.09397 11.785 15.3882 0 9.01731 9.46497 10.6836 8.2166 10.5707 9.49546 A0A8C0SZZ1 A0A8C0SZZ1_CANLF "Isocitrate dehydrogenase [NAD] subunit, mitochondrial" IDH3B Canis lupus familiaris (Dog) (Canis familiaris) isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] "magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" AVKKRWEE;NPGAWRNLGTSAVAHAASRSQAEDM;VLSSMKENK 3 11.4 0.98554 -0.25951 0 0 9.78349 0 0 0 0 0 0 0 0 0 10.3455 0 0 A0A8C0SZZ2 A0A8C0SZZ2_CANLF Transmembrane and coiled-coil domain family 2 TMCC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAAAAPNP;MKRCKSDELQQQQQQQQQQQQQQG 2 4.4 1.0036 -1.0631 0 0 0 0 0 0 0 0 0 0 9.06196 9.28852 0 0 5.77897 A0A8C0SZZ6 A0A8C0SZZ6_CANLF [histone H3]-dimethyl-L-lysine(36) demethylase (EC 1.14.11.27) KDM2B Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270] EQQPQEEKKEEEEEEEE;ETPEAQRDKLY;FSSDSWLEMEEESCE;GVSAKWTHLTEF;IDGFSSDSWLEMEEESCEQ;KKKVKIRRKRRLP;KKKVKIRRKRRLPTKE;KVKIRRKRRLP;LPLDDGAAHVMHR;LPNCWECPKCNHAGKT;LVDVMDVNTQKGTE;PPPDSLPLDDGAAH;PPTDNRPGQMDNRSK;VGTTTRDSLTEINLS;VLPHTAVC 15 13 0.97708 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 7.81378 0 A0A8C0T021 A0A8C0T021_CANLF Citron Rho-interacting kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] AEADADCD;EEMRLMMNQLE;EVQVVRERATGD;GIYSLDCDWWS;IVELSEANKLAANSSLF;LEKISHQDHSDKNRLL;MNFQRFLKFPDDPKVS;QEIKEQEYQA;RLMMNQLEEDLV;TELEETTAEAEE;TMERRENRLKDDIQ;TPLSQVNKVWDQS;TQRSLLEQDLATYI;TTCTMLEEQVMDLEALNDE;VGFSYSKAL;VPLQYNELKV 16 9.5 1.0039 -1.1044 0 0 0 0 0 0 0 0 6.21896 0 0 0 0 0 0 A0A8C0T024 A0A8C0T024_CANLF Guanylyl cyclase domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) AGRGPWGLRTEVEA;KNQSFYRKHFDTEETRVNQLF;VEKCGHRCFCGTPD 3 20.2 0.98923 -0.20357 0 0 7.36894 0 0 0 0 0 0 0 0 6.87061 0 6.21066 0 A0A8C0T036 A0A8C0T036_CANLF ATP binding cassette subfamily C member 12 ABCC12 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ETSRKSDLK;IIHAYDKKEDCISKFKM;LGIIHAYDK;LSAVDAHVGKHVFEEC;PWFSHITSSMQGLGIIH;SWLTPVMVRGYKHT;TLRGKTIVLVTHQLQ 7 6.8 1.0038 -1.6755 10.5553 4.27247 0 0 0 0 7.80832 12.4779 0 0 0 0 4.89462 9.5329 0 A0A8C0T045 A0A8C0T045_CANLF LRRNT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) inorganic cation transmembrane transport [GO:0098662]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655] plasma membrane [GO:0005886] DEQNATCVEPAE;SAGTVAAWLTGMCAV 2 8.6 0.98726 -0.22839 7.63496 0 0 0 0 0 0 0 0 0 0 0 9.10764 0 0 A0A8C0T052 A0A8C0T052_CANLF VWFC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGSTTVKIVLKEKHKK;GIFHLIQIKKNFRL 2 6.9 0.94012 0.060964 0 0 0 0 0 0 8.42878 0 0 0 0 0 0 0 0 A0A8C0T057 A0A8C0T057_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] NRWIFLLSKVVTLVKLLVLSFVII;PEMRYERNGVQVQDENEPAAEKLTL;WAPAYYAVTFAFLCSL 3 11.6 0.99222 -0.19324 0 9.87566 0 0 0 0 0 0 0 0 0 0 11.6777 0 0 A0A8C0T080 A0A8C0T080_CANLF Patatin like phospholipase domain containing 6 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470] endoplasmic reticulum membrane [GO:0005789] lysophospholipase activity [GO:0004622] AGVAVLVTAVLILLLVRR;DWTEWDGD;GVAVLVTAVLILLLVRRLRV;GVAVLVTAVLILLLVRRLRVPK;GVMIGAGVAVLVTAVLILLLV;GVMIGAGVAVLVTAVLILLLVRR;GVMIGAGVAVLVTAVLILLLVRRL;IDCFKTMDFGKF;IVGLGDQEPTLGQ;LILLLVRRLRVPKT;LVRRLRVPKTPA;PQVLGVMIGAGVAVLVTAVLILLLV;SEMEEEKSVL;TAVLILLLVRRLRVPKTP;VAVLVTAVLILLLVRRL;VLILLLVRRLRVP;VLVTAVLILLLVRRLRV 17 9.4 1.003 -1.955 4.83678 9.337 0 2.498 9.07001 5.76115 8.72325 10.5681 6.72438 9.56281 9.824 7.42316 3.97177 5.96708 10.0958 A0A8C0T098 A0A8C0T098_CANLF t-SNARE coiled-coil homology domain-containing protein STX16 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] Golgi apparatus [GO:0005794]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] ILILFVLIVVLIVVLIGVKSH;KKKKKKKK;KMLVILILFVLIVVLIVVL;LIVVLIVVLIGVK;LVILILFVLIVVLIVVLIGV;MLVILILFVLIVVLIVVLIGV;NVVASLAQALQELST;RKMLVILILFVLIVVLIVVL;VILILFVLIVVLIVVLI 9 8.8 0.98923 -0.20351 6.5092 0 0 8.41249 8.62055 8.82928 3.48143 0 0 8.10135 0 0 0 8.55209 0 A0A8C0T099 A0A8C0T099_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" AGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] PSLSPVEPLGGRFKKE;QSCESSKNKSRLTSQSE;RPDGMQQRSYSV;SLQSCESSKNKSRLTSQ;YHYYSRMANYRNTSEIPLVLVGTQ 5 9 0.96154 0.049233 0 0 0 0 0 0 0 10.7861 0 0 0 0 0 0 0 A0A8C0T0D5 A0A8C0T0D5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;EKKQQIDLTPKRRKELIKIR;MDAFLESHKL;MNEKGEITTNT 4 5 0.9745 0.048206 0 0 0 0 0 0 3.9925 0 0 0 0 0 0 0 0 A0A8C0T0D6 A0A8C0T0D6_CANLF Tetratricopeptide repeat protein 30 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport [GO:0042073] axonemal microtubule [GO:0005879] AAQEALTDMP;ALAAECYEQLGQLHPELEQYRLY;ENKYKEAIGFY;GGDDSGGD;LDNPAYRGRVLRLQ;PDLSYNLALAYYSR;QLLSAEGGDDSGGDGEPD;VAHVLFMQENKYK 8 16.6 1.0024 -1.3724 3.86997 10.0918 0 0 9.96421 0 13.3447 0 9.14878 11.4887 11.4407 0 0 11.3343 0 A0A8C0T0D8 A0A8C0T0D8_CANLF "Legumain (EC 3.4.22.34) (Protease, cysteine 1)" LGMN Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] cysteine-type endopeptidase activity [GO:0004197] MVFYIEACESGSMM;PQNFLAVLRGDEEA;RTLVEQIHRHLDYEYAL 3 12 0.9801 0.046227 0 5.90468 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T0E0 A0A8C0T0E0_CANLF KIAA1755 Canis lupus familiaris (Dog) (Canis familiaris) APAPGTKVEERAKQ;DEPCLLGFRRK;GGSPSREVE;LETIEKAHAEFEDFFLQ;QEGLGQDLWEE;YCHGEWVQFFQK 6 6.2 1.0022 -1.134 0 0 0 10.0176 6.75809 3.64386 0 11.9509 0 0 9.38303 0 0 0 4.67084 A0A8C0T0E4 A0A8C0T0E4_CANLF Transmembrane protein 140 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PEPALLPP;TVVVISLLFYALLWK 2 6.4 1.0049 -1.0505 0 0 0 0 0 0 9.93621 0 0 0 5.93941 0 7.56811 0 0 A0A8C0T0F5 A0A8C0T0F5_CANLF Phosphodiesterase (EC 3.1.4.-) PDE1B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DETRQILDTEDE;FRSTWTKYIQ;LRFALFFYFYHLGDET;VEVGDPNPDVVRFRSTWTKYIQEN;VGPTYSTV;VLNCLKNLDRWCFDV 6 14 0.96128 0.049233 0 6.64976 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T0G7 A0A8C0T0G7_CANLF Fms related receptor tyrosine kinase 3 ligand Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine activity [GO:0005125] DRTSGFLEGEMRFHRNWG;LLLLLLLP;PAPQAPRLLLLLLLPVALLL;RLLLLLLL 4 10.4 0.97295 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.6139 0 0 A0A8C0T0H2 A0A8C0T0H2_CANLF SH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVPPGAGGP;SEPRPAPPPKPS 2 5.9 1.0041 -1.1009 9.50728 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T0I4 A0A8C0T0I4_CANLF G protein signaling modulator 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTPase regulator activity [GO:0030695] AAFFEAAVQVGTEDLKTLSAI;AAPTPEERVEPHP;KSRQGASNGP 3 5.7 0.99084 -0.14815 0 7.19781 9.78996 0 0 0 0 0 0 0 0 0 0 0 8.62194 A0A8C0T0J0 A0A8C0T0J0_CANLF Rho guanine nucleotide exchange factor 12 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DEQFENDLETDPPNWQQLV;EVGYLPANPMSSV;EVINELFYT;LPQSPPCEGDNDEE;LSEYPNVEELRNLD;MEDSCFEIQSPP;PEDLHRHYIQ;SEYPNVEELRNLDL 8 6.2 1.0021 -1.2785 8.60452 8.91088 13.5127 0 0 0 0 0 0 10.4773 0 12.4524 0 0 8.54117 A0A8C0T0J7 A0A8C0T0J7_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] centrosome [GO:0005813]; perinuclear region of cytoplasm [GO:0048471] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] EDLVLMLPQNIWDNLYSRYG;EETMEEDKSQSDV;ELWHKSRPG;EWESFVKGKDGDP;IEDLVLMLPQNI;SPPKSGNLWPGLASTHKKA 6 8.7 1.0032 -1.5008 10.0682 0 6.74886 0 9.54969 0 7.86592 0 0 0 0 0 0 0 0 A0A8C0T0L3 A0A8C0T0L3_CANLF Proline rich transmembrane protein 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGIAAMVLCTILT 1 4.3 0.98224 -0.25108 8.42857 0 0 0 0 0 0 0 8.48563 0 0 0 0 0 0 A0A8C0T0M1 A0A8C0T0M1_CANLF Pyruvate dehydrogenase E1 component subunit alpha (EC 1.2.4.1) Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006] intracellular membrane-bounded organelle [GO:0043231] pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739] EELKEIDVEVRKEIEDAAQFATADP;LSCLSQGMGQRL;SYRTREEIQEV 3 11.1 0.99207 -0.54341 0 0 0 9.82483 0 0 0 0 6.0454 0 0 0 0 0 0 A0A8C0T0M9 A0A8C0T0M9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] KQNISKEMKALNDTLDQMDFTDIY;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 4 4.5 0.97229 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 9.66354 0 0 A0A8C0T0N8 A0A8C0T0N8_CANLF SNW domain-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] LQRNENRDISEVI;MALTSFLPAPTQ;NPRTSNEVQYDQRLFNQSKG;RHDRRKERQHD 4 10.9 0.84632 0.19438 0 0 0 2.98453 0 0 0 0 0 0 0 7.81397 11.1851 0 0 A0A8C0T0Q0 A0A8C0T0Q0_CANLF Autophagy-related protein 101 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045] phagophore assembly site [GO:0000407] IDFTYVRVSSEELD;LLHRSTGKFHYKKEGTYSIGT;TYVRVSSEE;VGTQDVDCDFIDF 4 21 0.98532 -0.44379 0 0 0 9.39624 0 0 0 0 0 6.86592 0 0 0 0 0 A0A8C0T0Q6 A0A8C0T0Q6_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] SRGRGRPREARARQRR 1 2.7 0.9605 0.049233 5.01788 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T0R1 A0A8C0T0R1_CANLF von Willebrand factor D and EGF domains VWDE Canis lupus familiaris (Dog) (Canis familiaris) cell surface [GO:0009986]; extracellular region [GO:0005576] calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102] AFDVSPTNTSVGF;CMEWGCACSPGFGSYDCSDSHD;CNRHCENGGECLTPDICQC;DAKLYPCDPDEI;DCSDSHDM;DTVTFDMCSGQLHESQPY;NIRKYNCMIVRVFGKGF;PLISSYVHHKPVVRMKFLIQKKLKI;RQLSASLPPPPPGRP;TCDEEHCSPPCQHGGTC;TSVGFLIT 11 9.7 1.0031 -2.4578 10.2943 0 8.3285 0 7.34669 0 10.0309 0 6.93758 11.6639 8.23573 3.8495 0 0 8.65342 A0A8C0T0T6 A0A8C0T0T6_CANLF Ran-binding protein 9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; plasma membrane [GO:0005886] AAGGGGGG;DVDMETEHYSNGV;NGSSKHDHEMEDCD;NGSSKHDHEMEDCDTEME;PAAAARRRRRRR;PIPAACGIYYFEVK;YCATAEAFARSTD 7 7 0.99215 -0.038119 0 0 0 0 0 0 9.55654 0 0 6.2541 6.21901 0 5.49665 0 8.94002 A0A8C0T0T8 A0A8C0T0T8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FAQQQSIFPDF;IFTCKFAQ;PAWGEGTAP 3 6.4 1.002 -1.2789 0 0 0 0 0 0 9.18728 0 0 0 0 7.8421 0 0 0 A0A8C0T0U8 A0A8C0T0U8_CANLF THO complex 3 THOC3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] THO complex part of transcription export complex [GO:0000445] DVRTTKCIATVNTKG;HDGKMLASASEDHFI 2 9.2 0.99401 -0.16136 0 0 0 0 0 0 0 0 0 0 9.85144 0 0 9.52534 0 A0A8C0T0V5 A0A8C0T0V5_CANLF PHTF1/2 N-terminal domain-containing protein PHTF2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] EDLLHCAEC;LILGLTPFVF;QDSESTRP;STGGKRRRSKKAKN;TRPESETEDVLWEDLLH 5 7.2 0.93285 0.060813 0 0 0 0 0 0 9.02926 0 0 0 0 0 0 0 0 A0A8C0T0V8 A0A8C0T0V8_CANLF Transmembrane protein 121B TMEM121B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGGSGTGGGASRCSCCCCCCCC;ASRCSCCCCCCC;ASRCSCCCCCCCCGR;CCCCCCCCGR;CCCCCCCCGRPG;CCCCCCCG;CCCCCCCGRPG;CSCCCCCCCCG;CSCCCCCCCCGRPG;GASRCSCCCCCCCC;GASRCSCCCCCCCCGR;GASRCSCCCCCCCCGRPG;GGASRCSCCCCCCCCG;GGASRCSCCCCCCCCGRPG;GGGASRCSCCCCCCC;GGGASRCSCCCCCCCCG;GGGASRCSCCCCCCCCGRP;GGGGGGGG;GGSGTGGGASRCSCCCCCCCC;GSGTGGGASRCSCCCCCCC;GTGGGASRCSCCCCCC;GTGGGASRCSCCCCCCC;RCSCCCCCCC;SCCCCCCCCG;SCCCCCCCCGR;SCCCCCCCCGRP;SCCCCCCCCGRPG;SGTGGGASRCSCCCCCCC;SRCSCCCCCCC;SRCSCCCCCCCC;SRCSCCCCCCCCGR;STSTSTSRG;TGGGASRCSCCCCCC;TGGGASRCSCCCCCCCC;TGGGASRCSCCCCCCCCG 35 8.3 0.99765 -3.3919 7.5678 11.4181 9.31805 3.48246 5.93315 6.11805 7.57546 7.80465 7.88838 6.29416 4.94823 7.69891 8.32513 9.24764 8.58804 A0A8C0T0V9 A0A8C0T0V9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVMSSDTL;LLLSSPGVMSSDT 2 5 1.0044 -1.0444 0 0 0 0 0 8.89545 9.35065 0 0 0 0 0 0 0 0 A0A8C0T0W3 A0A8C0T0W3_CANLF Testis anion transporter 1 (Solute carrier family 26 member 8) SLC26A8 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; inorganic anion transmembrane transport [GO:0098661]; meiotic cell cycle [GO:0051321]; spermatogenesis [GO:0007283] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] CQCFCNCDE;ESSELSMDESETVI;LEPEPELG;QNYEDMDKAW;SQSISDDQGPYT;TIFPFLEWVCLYRFKDW 7 9.2 0.93151 0.060769 0 0 0 0 0 0 7.89797 0 0 0 0 0 0 0 0 A0A8C0T0Y9 A0A8C0T0Y9_CANLF "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9" Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] membrane [GO:0016020] hexosyltransferase activity [GO:0016758] RAAWGSPLRLVSRRRRRCPR 1 3.5 0.97402 0.048206 0 0 7.3427 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T0Z3 A0A8C0T0Z3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;FLIKTLQSVGIEGTFFNIL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 6.9 0.949 0.049568 0 0 0 0 0 0 0 0 0 0 8.09498 0 0 0 0 A0A8C0T100 A0A8C0T100_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GEDEGLGAED;GPQGPGAAHSHLAPSPPSPVFP;GVPVHRLP 3 4.7 1.0044 -0.82039 0 0 8.95463 0 0 0 9.79282 0 0 0 0 8.12547 0 0 10.3505 A0A8C0T129 A0A8C0T129_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVGLLEVSVAGLSLLLLRRALRRE;SLLLLRRALRRE 2 6.5 0.93338 0.091743 0 5.97435 0 0 0 0 0 0 0 0 0 0 0 8.55005 0 A0A8C0T142 A0A8C0T142_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" AEEAAPGAQGG;EEEEEAPNEEETCEN;EFMNYFHALEIGYRE;FYEQGDEEASL;GGAAGGGA;LQQHSSEQIQAIREE;QAIREEEE;SASRTPSRTDDTT;SFLLALLLRL;VLRLRLGV 10 9.5 0.99653 -4.952 7.26669 0 6.02456 0 0 0 10.0356 0 9.45187 9.07601 0 9.58084 6.48232 7.78097 13.6231 A0A8C0T151 A0A8C0T151_CANLF "Prostate transmembrane protein, androgen induced 1" Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139] R-SMAD binding [GO:0070412] PGAKKRINRKGHPL;PTYPYLQHQIDLPPTISLSDG;RASRSPSP 3 11.1 0.99692 -0.10074 0 0 0 0 0 0 0 5.53531 0 11.1164 0 0 0 0 0 A0A8C0T154 A0A8C0T154_CANLF Islet amyloid polypeptide IAPP Canis lupus familiaris (Dog) (Canis familiaris) LLKLPVVLIIL 1 14.1 0.9805 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 3.16803 0 0 A0A8C0T161 A0A8C0T161_CANLF Thrombospondin-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] DDILASPPRLLD;GHKGEIGFPGRP;GLPGVKGDPGIVGPPGA;GVPGPEVGAAARGHPARAPRPA;PGPPGPPGTM;TMGTSSGV;TMGTSSGVRIWAT;VPEGWLMFVAEREE 8 7.2 0.97519 0.048251 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.84348 A0A8C0T168 A0A8C0T168_CANLF Aldehyde dehydrogenase family 16 member A1 ALDH16A1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AGPEIGPSP;EVELSVRQLRAWGARAQA;VGLILSPTFSFLEMMWR;VLAGWEPMG;VLTEAADVDSAVEGVV 5 8.6 0.98613 -0.38899 0 0 0 9.63501 7.29251 0 0 0 0 0 0 0 9.32517 0 0 A0A8C0T169 A0A8C0T169_CANLF Dedicator of cytokinesis 10 DOCK10 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AEYKPEKLPS;AVSSRQQQRQEKPRLLEPL;DEWIHTLNR;FSPLYRQESS;GVVQNNRLRKYAFELKMNDLTYFV;IIAVFEKQRDF;SKGGGGAG;SSSKGGGG;SVDRDSRFSPLYRQE;TVPEDAEHKAE;VTPRQSEEPH 11 5.9 0.95245 0.049538 0 0 0 0 0 0 8.03138 0 0 0 0 0 0 0 0 A0A8C0T172 A0A8C0T172_CANLF Coiled-coil domain containing 187 CCDC187 Canis lupus familiaris (Dog) (Canis familiaris) microtubule anchoring [GO:0034453] centrosome [GO:0005813] microtubule binding [GO:0008017] DFPPPPEDAMFPRGPPEED;DFSSSPMEDPHQMESWWL;DTLVASGWPD;EDPHQMESWWL;GSSGGHES;RIPQRQASVP;TAKLHKSEAPDTVGDPV;VPSLSKKA 8 4.7 1.0032 -2.261 0 0 10.3971 0 0 8.27463 8.8996 0 10.7133 0 10.5647 0 1.86251 0 8.01184 A0A8C0T177 A0A8C0T177_CANLF Centrosomal protein 295 CEP295 Canis lupus familiaris (Dog) (Canis familiaris) ALEKFTSVDLDFPELEHTFPNLH;DSFATLPSARAE;EKSGEELSDRQTQL;EVTTTVSETESKAPTVESGAT;EWQKQVAQERMEQHE;LNQHELSAIPEVESPAS;LQGQLNTQRDSLQARRE;SDYPDLSE;SESGRIQEPCSTKS;SQDSRDFYQNSDSSCESH;TELLLHRQRDLGNGK 11 7.1 1.0026 -1.1487 7.38698 0 5.49675 0 0 0 8.3619 6.9384 7.84248 11.3494 10.8195 8.32683 11.0313 0 6.71383 A0A8C0T178 A0A8C0T178_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) YWHKNRHIDQWNRIENPELDPE 1 3.2 0.98384 -0.23829 0 0 0 0 0 0 0 0 0 0 9.49263 0 0 0 0 A0A8C0T1B4 A0A8C0T1B4_CANLF Intercellular adhesion molecule N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] integrin binding [GO:0005178] LSLAMAPLYMKRFGPQVPQEL;LVSNISQDTIIYCYFTCFGEQRLTS;PAALLALFCC;YCYFTCFGEQRLTSLNVS 4 14.4 1.002 -1.4315 0 0 0 0 0 0 0 0 0 0 7.4884 0 9.14463 0 10.7334 A0A8C0T1E8 A0A8C0T1E8_CANLF FYVE and coiled-coil domain autophagy adaptor 1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ELRALESQCHQQT;EVTNREKNDQKMLADLDDL;WQKSDALEFQQKLSAE 3 3.6 0.8564 0.16382 9.39021 0 7.3726 0 0 0 0 8.33923 0 0 0 0 0 0 0 A0A8C0T1I1 A0A8C0T1I1_CANLF "RAB35, member RAS oncogene family" RAB35 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; Rab protein signal transduction [GO:0032482] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] RGGGAEGG;RRLLRRRRRR;VYDVTSAESFVNVKRW 3 9.4 0.99449 -0.56222 0 0 0 0 0 0 0 0 0 5.90643 0 4.83081 0 0 0 A0A8C0T1J0 A0A8C0T1J0_CANLF Dedicator of cytokinesis 10 DOCK10 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AEYKPEKLPS;DEWIHTLNR;FSPLYRQESS;GVVQNNRLRKYAFELKMNDLTYFV;IIAVFEKQRDF;SKGGGGAG;SSSKGGGG;SVDRDSRFSPLYRQE;TVPEDAEHKAE;VSDFFSILEKIAA;VTPRQSEEPH 11 5.3 0.9845 -0.23951 0 0 0 0 0 0 0 0 0 0 0 0 10.2174 0 0 A0A8C0T1J8 A0A8C0T1J8_CANLF Beta-catenin-like protein 1 N-terminal domain-containing protein CTNNBL1 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex [GO:0005681] EFLKAFRMAAMYA;GEGLQLMNLM;RTIFPLFMKSPRKIKKVG;VLDHAMIGPE 4 8.6 1.0032 -1.1187 0 0 0 0 0 0 0 0 12.6673 0 0 0 0 0 0 A0A8C0T1L1 A0A8C0T1L1_CANLF C2H2-type domain-containing protein ZNF467 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" VLEVACSL 1 1.4 1.004 -1.1044 0 0 10.4388 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T1N2 A0A8C0T1N2_CANLF Heparan-sulfate 6-O-sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sulfotransferase activity [GO:0008146] DLFPTPDPHYEK;FPVRELERSL;VAGSACFMLILYQYAGPGLSLG 3 10.7 0.98556 -0.4433 0 0 10.1865 0 0 0 0 8.65714 0 0 9.76142 0 0 0 0 A0A8C0T1R6 A0A8C0T1R6_CANLF Transmembrane protein 220 TMEM220 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLVGLNPLVTGNFIWK;MAAFFALA;NWLMAAFFALAALV 3 18 1.002 -0.68381 8.64209 0 8.57607 0 0 0 0 0 0 0 0 11.5651 0 0 0 A0A8C0T1S1 A0A8C0T1S1_CANLF DNA helicase (EC 3.6.4.12) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] ADVTRLPA;CNHPYLFPVAAMEAPKMPN;DETEDTELQ;DGVPREGLS;DWGMEDIDHVFS;DYTPGKKKKKKLGPKKEKKSKSKRK;EEEEEDDDD;EPPSGDFGGDEEK;ERFQKYYK;ETPKLKKKKKPKK;GKKKKKKLGPKKEKKSKSKR;GKKLKKVKLRKL;ILEEVGGDPEEEDDHH;KKLKKVKLRKLERPPETPTV;PDAKKPKPKKVAPLKIK;PGKKLKKVKLRKL;PKLKKKKKPKKPRDP;QEDLARNLGKGKRIRKQV;RQHVLTRIGVM;RWSMPELAEVEENK;RYGMPPQDAFTTQWLVRDLRGKSEK;SEEGDEDFDE;TYVGDKDSRAIIRENEF;VDLTPIVV;WEREFEMWAPDMYV;YDDKAIERLLDRNQ;YHMVCLDPDMEKA 27 17 0.99671 -4.2638 12.4217 12.201 7.55559 6.285 9.42381 8.693 13.112 12.4856 10.6909 5.56175 12.3445 7.64126 9.34873 5.32578 0 A0A8C0T1U8 A0A8C0T1U8_CANLF G-protein coupled receptors family 1 profile domain-containing protein LOC119864894 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CTFMVMAY;SWKFWLSLPLSF 2 6.3 0.98313 -0.25582 0 0 8.3102 0 0 8.95242 0 0 0 0 0 0 0 0 0 A0A8C0T1V0 A0A8C0T1V0_CANLF von Willebrand factor D and EGF domains VWDE Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AFDVSPTNTSVGF;CMEWGCACSPGFGSYDCSDSHD;DAKLYPCDPDEI;DCSDSHDM;DTVTFDMCSGQLHESQPY;NIRKYNCMIVRVFGKGF;RQLSASLPPPPPGRP;SLPMWTLPLWIL;TSVGFLIT 9 7.9 0.95134 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 4.53773 0 0 A0A8C0T1V6 A0A8C0T1V6_CANLF "Lipase A, lysosomal acid type" Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] hydrolase activity [GO:0016787] GILLPQITHLVY;RGGAGHEG 2 4.1 0.9896 -0.21408 0 0 0 0 0 0 0 0 0 0 0 8.55175 0 5.53176 0 A0A8C0T1W2 A0A8C0T1W2_CANLF Transmembrane protein 70 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] membrane [GO:0016020]; mitochondrion [GO:0005739] GNLARTVF;SPLVGRRA;YDKPFTFDTEADSEKKQ 3 12.9 0.98764 -0.47755 0 3.86334 10.8768 8.90629 0 8.59775 13.414 6.52837 10.8945 0 0 10.748 4.5196 0 10.4395 A0A8C0T1W5 A0A8C0T1W5_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAPSPLAAAAGG;GPAAPSPLAAAAGGSGALPGA;PGAPEAAPCGCCCCCG;VQNQYPDVGTRERLAG 4 26.5 0.98753 -0.40457 0 8.65141 0 0 0 6.17379 0 7.70522 0 0 0 0 0 0 9.16191 A0A8C0T1X3 A0A8C0T1X3_CANLF Aspartate beta-hydroxylase Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101] ADDLTYQDYDEPV;DPGAAAGA;EQVIEDSGPQ;KRGHFASVWQ;LLHEAVYTEHETED;QFLGHMRGSL;VIEDSGPQNT;VPPVKKKKPKLLNKFDK 8 7.9 1.0021 -2.6097 11.3561 9.79572 0 4.80287 0 0 0 0 0 11.4912 10.9936 0 0 8.19879 0 A0A8C0T1Y2 A0A8C0T1Y2_CANLF V-type proton ATPase subunit E 1 (V-type proton ATPase subunit e 1) (Vacuolar proton pump subunit E 1) Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; synaptic vesicle membrane [GO:0030672]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" QTQRLKIMEYCEKKEKQ 1 11.5 0.97884 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 6.34701 0 A0A8C0T1Y9 A0A8C0T1Y9_CANLF Niban apoptosis regulator 2 NIBAN2 Canis lupus familiaris (Dog) (Canis familiaris) AVYRMVYEQAKARFE;FCMMTEAEQDKWQAVLQDCI;HYYFCMMTEAEQDKWQA;VLSTHLDDARRQHIAEK 4 7.4 0.99447 -0.026274 10.2912 0 9.38993 11.9276 0 13.1609 0 12.9693 11.4904 0 0 8.43338 11.006 0 11.37 A0A8C0T1Z0 A0A8C0T1Z0_CANLF "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] L-malate dehydrogenase activity [GO:0030060] EVFKKHGAYDSN 1 3.7 0.94747 0.05044 7.22805 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T203 A0A8C0T203_CANLF Out at first protein homolog OAF Canis lupus familiaris (Dog) (Canis familiaris) LAPPRLLLLLLAPLL 1 5.7 0.95062 0.053874 6.09588 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T216 A0A8C0T216_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] AGSPPGITNSFFR;GKPVLRISSDPP;IDLENIVYYKDC;KFCAGSIDH;LDPLDHRNFY;LHFRDNAYNYCYT;LLCAENVN;LNWIRGLL;PSVVVTGHVLRELKQVSAGGE;SQQRKRRAELKQQREEEGTWKEQE;VLEPPEDQENQK 11 12 1.0018 -1.2937 0 0 0 0 0 8.07248 0 0 0 4.43356 0 0 0 5.9486 0 A0A8C0T223 A0A8C0T223_CANLF Ig-like domain-containing protein LOC119867047 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APSEQGQN;LSRLPSRAQGGAG 2 3.9 1.0042 -1.0445 7.24907 11.533 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T234 A0A8C0T234_CANLF Transporter Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] KDMESLEELS;LIPISLLLLNFLTLFQLTS 2 4.6 0.99419 -0.56205 0 0 0 0 0 0 0 0 0 0 0 6.55096 11.6094 0 0 A0A8C0T240 A0A8C0T240_CANLF WD repeat domain 33 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] EGMIWSLAWHPLGH;ETILQAHDSPVRAM;FLRCHEERILR;FQAHKEAIREASFSPTDNKFATC;GLGQQGAQGRI;GRKGLLPTPDEFPRF;QRDQRDMRAIQPD;SPASRERSSSLQG;YTNPQLLEQLK 9 9.4 0.98942 -0.50884 9.459 0 9.35929 12.0582 9.3626 6.05663 0 0 0 0 0 0 0 10.7333 11.9794 A0A8C0T253 A0A8C0T253_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] SHSRSYSRDYGR 1 4.7 0.9501 0.05044 0 0 0 0 7.83219 0 0 0 0 0 0 0 0 0 0 A0A8C0T255 A0A8C0T255_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSVLSTSETFYSL 1 4 0.94072 0.05986 7.57266 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T260 A0A8C0T260_CANLF Myozenin 2 MYOZ2 Canis lupus familiaris (Dog) (Canis familiaris) Z disc [GO:0030018] PKYYQSPWEQAI;VLGPGCEI 2 6.5 0.99411 -0.56193 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8769 0 A0A8C0T266 A0A8C0T266_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EALLLLLLSLGLLLG;LLLLLLLL;LLLLLLLLL;LLLLLLLLLV;PQEALLLLLLSLG;PVLLLLLLLLLV;VLLLLLLLL 7 22.1 0.85789 0.16388 0 0 0 0 4.86562 0 0 0 5.31288 5.64322 0 0 7.61442 6.0297 0 A0A8C0T270 A0A8C0T270_CANLF Solute carrier family 33 member 1 SLC33A1 Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA transmembrane transport [GO:0035348] membrane [GO:0016020] acetyl-CoA transmembrane transporter activity [GO:0008521] EERNARGQGGMHGL;VGYASTCNSVGQTAGYF;WWTPRVEHQGG 3 6.4 0.87318 0.14266 0 0 7.94462 0 0 3.57022 5.18717 0 0 0 0 0 0 0 0 A0A8C0T289 A0A8C0T289_CANLF Eukaryotic peptide chain release factor subunit 1 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasm [GO:0005737] translation release factor activity [GO:0003747] IVIDGSGALFGTL;VEIWKIKKLIK 2 6.1 0.99009 -0.21984 0 0 0 0 0 0 0 0 0 0 12.1091 12.1644 0 0 4.96403 A0A8C0T296 A0A8C0T296_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; transferase activity [GO:0016740] AGRAPPTGAPGQGAP;GRDWASGREAGP 2 3.9 0.93684 0.10434 0 0 0 8.40088 0 0 0 0 0 0 0 0 0 0 6.51474 A0A8C0T298 A0A8C0T298_CANLF VWFC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGSTTVKIVLKEKHKK;LWKLIKGYWNVFL;QVEIYLWKLIKGYWNV 3 11.7 0.9917 0.0043445 4.68644 0 0 0 0 0 0 9.59147 0 0 0 0 4.59335 0 0 A0A8C0T2A8 A0A8C0T2A8_CANLF CHHC U11-48K-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CYHPLLDLRAL;ISVISCFHFSVL;LWEQTSTP;SLHSSLGP 4 6.9 1.0032 -2.1434 0 0 0 12.6979 0 0 0 0 0 0 0 0 10.7241 0 0 A0A8C0T2B6 A0A8C0T2B6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway [GO:0097193] mitochondrial inner membrane [GO:0005743] RIWNKLRLKQKI 1 16.2 0.94842 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.16148 A0A8C0T2E2 A0A8C0T2E2_CANLF Nitric oxide associated 1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] AEENLSPQEQ;MGGEERMAGFPPLVGE;PSCLVRGLSRGSAAPG;VGRTFLYSEERKEE;VQMSREQYL 5 9.3 0.93441 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 4.84298 0 A0A8C0T2E6 A0A8C0T2E6_CANLF FHA domain-containing protein NBN Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095] chromosome [GO:0005694]; Mre11 complex [GO:0030870] GAAGCAGP;GGSDLVAH;MLPRKVLLTEFRSLVV;TELEEWLRQ;TSEISIKDELE 5 5.6 0.99913 -2.9283 0 7.02791 0 9.53428 12.743 0 0 10.607 10.4599 0 2.36866 0 0 7.95111 7.74423 A0A8C0T2G0 A0A8C0T2G0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PKMYT1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AHPASWLQPPS;FRHAEPGFSLKRP;RKLAEVGG;SGTPVPVPAYFRHAEP;YLQTELCGPSLQ 5 11.7 0.9896 -0.31707 9.20582 0 3.82599 0 0 0 0 0 0 0 0 0 0 8.85748 0 A0A8C0T2G6 A0A8C0T2G6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] NECEKTFISKTVLTIHQ;SYECYECG;VHQRVHNRETHHECLA 3 8.8 1.003 -1.0089 0 0 3.28465 0 0 0 0 0 10.1565 0 6.91695 0 0 0 0 A0A8C0T2H7 A0A8C0T2H7_CANLF Transmembrane protein 250 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGVRVLLRFQLKLSVLLLLL;RFQLKLSVLLLLLGRRRVDFRL 2 20.9 0.92847 0.094905 0 0 5.59887 0 0 0 0 7.74275 0 0 0 0 0 0 0 A0A8C0T2J0 A0A8C0T2J0_CANLF Beta-carotene oxygenase 1 BCO1 Canis lupus familiaris (Dog) (Canis familiaris) beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574] "beta-carotene 15,15'-dioxygenase activity [GO:0003834]; metal ion binding [GO:0046872]" DEDDGIILSAI;FTIRDGEVYYRSKYLRSDTYKDN;LFVPTPGA;YPDPCKNIFSKAFSY 4 10.4 1.0019 -0.96619 6.54561 0 0 0 0 0 0 0 9.43507 10.5358 0 0 8.70162 0 0 A0A8C0T2L3 A0A8C0T2L3_CANLF Zinc finger piccolo-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; organelle [GO:0043226]; presynaptic active zone [GO:0048786] metal ion binding [GO:0046872] AVYEEILQTSQSIARM;AYEEMMRKAELLQRQQ;DEELEDILEEE;EHRHHGDHGRHS;EKTEWLCLNCQTKRL;ELHKVGSSMRPSLEA;GPTTPQPKPESQPQPQGRQVAP;HGRLYSSMSDT;HITAVTDPKVE;KKNVYEQQRYYGVS;LQTSQSIA;LYRYPAPSRFPTASS;PGGPQPGP;PLEIGYQAQLP;SPATANYGSQTEE;SQGPGAPA 16 5.1 0.99736 -3.4991 8.86787 10.6931 11.634 6.25788 11.0066 0 9.42694 0 9.07192 8.66519 5.70302 8.94743 8.70515 10.916 7.95582 A0A8C0T2P9 A0A8C0T2P9_CANLF poly(A)-specific ribonuclease (EC 3.1.13.4) CNOT6L Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535] DKYATRQLYGYCP;ESKKAIRAKEKTGE;FFKTEKFTLVQ;LSNGGVAD;PGGGAEAR 5 5.9 0.98564 -0.43511 13.3552 13.629 0 0 0 0 0 0 0 13.2363 0 0 9.32434 0 9.25793 A0A8C0T2Q4 A0A8C0T2Q4_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] melatonin receptor activity [GO:0008502] LVLQARKKVKSEPKLRLRPS;WALGEVHCKASAFVMGLSVIGSV 2 15.2 0.98498 -0.23675 0 0 0 0 0 0 0 6.68229 0 8.49189 0 0 0 0 0 A0A8C0T2Q7 A0A8C0T2Q7_CANLF Potassium inwardly rectifying channel subfamily J member 9 KCNJ9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of presynaptic membrane potential [GO:0099505] monoatomic ion channel complex [GO:0034702]; parallel fiber to Purkinje cell synapse [GO:0098688]; presynaptic membrane [GO:0042734] G-protein activated inward rectifier potassium channel activity [GO:0015467] DERAEEEGPGEGAD;EDGFYEVDYASF;TIGYGHRVITDQCPE;VEKDGRCNV 4 12.8 1.0018 -0.96009 0 7.96371 0 0 0 0 0 10.3245 7.47127 0 9.01461 0 0 0 0 A0A8C0T2R9 A0A8C0T2R9_CANLF Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] GTTILAFLVFMPMLHGRNL;VLSVLVLLLLAVLMRRRQLRPRCRH;VLVLLLLAVLMRRRQLR;VPAAVFMVLFSS 4 8.7 0.94746 0.049553 0 0 5.80206 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T2T4 A0A8C0T2T4_CANLF Neurexin 3 NRXN3 Canis lupus familiaris (Dog) (Canis familiaris) presynaptic membrane [GO:0042734] DDEDFIECEPSTG;DSCANQGVCMQQWE;GLILPTELWTAMLNYG;ITLPPTFRPL;PQPDLVLLPL;VITRDNSN 6 4.3 1.0031 -2.4792 0 0 6.55175 8.40574 2.93066 0 0 6.45626 0 0 0 9.78867 9.63292 0 0 A0A8C0T2T8 A0A8C0T2T8_CANLF AMMECR1 like AMMECR1L Canis lupus familiaris (Dog) (Canis familiaris) TAEMCCYCFDVLYCH 1 5.3 0.95285 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.57936 A0A8C0T2T9 A0A8C0T2T9_CANLF Solute carrier family 25 member 45 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GDGMGWEDAVAP;QERWAQPPSYTHVFMAGCT;TYRHESLLGFFK 3 12.5 0.84978 0.15076 0 0 0 0 8.9249 0 0 0 0 0 7.58797 0 8.0974 0 0 A0A8C0T2U1 A0A8C0T2U1_CANLF Butyrophilin subfamily 1 member A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EEGFSSGS;KREHTAKKGWL 2 3.8 1.0022 -1.3717 0 0 0 0 0 0 6.14382 12.5197 0 0 0 0 0 0 7.84153 A0A8C0T2U3 A0A8C0T2U3_CANLF Fibrillin 1 FBN1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] CTDIDECEDNPNICDGGQ;DECREIPGVCENGV;DECSIMNGGCETFCTNSEGSY;EECTLPVAGRHRMDACCCSV;GCETFCTNSEGSYECSCQ;GTCSNTEG;GYPPPPLG;IDECQRDP;MMTCEDINEC;NNDCIDVDEC;SCEDVDECEGNHRCQHG;SNYRTGPCFTV;TPGDFECKCDEGYE;TQHHTACIDNNE;VGRAWGHPCEMCPAQPH;VGSFQCQCNEGYE;VILEDIDE;YHCLCKNGYTPDITGTSC;YTSHGADANLEAGNV 19 8.8 0.99686 -4.4582 0 5.06906 12.5801 0 11.8991 11.7693 5.98577 0 5.79129 13.6889 10.969 0 0 7.44419 13.0189 A0A8C0T2U4 A0A8C0T2U4_CANLF Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) USP15 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] AERRIWTSSAPTSRRC;EDSNDNDNDIENENCMH;EDTEHVII;GGGGQQGGE;PGLCGLSNLGNTCF;PLESDEDSNDNDND 6 6.8 1.0031 -2.298 0 0 0 0 6.38957 5.96426 9.87563 10.2081 2.87552 0 4.04632 0 0 0 0 A0A8C0T2V0 A0A8C0T2V0_CANLF Zinc finger protein 41 ZNF41 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CGKAFTRK;FTKKSQLRVHQKIH;TPHQSCLDEDVGEM 3 4.7 0.98274 -0.25159 0 0 0 0 0 0 0 0 0 0 8.45557 0 0 0 0 A0A8C0T2X2 A0A8C0T2X2_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] ILLPDDIEDESTGLKKIEEHLTL;LFTGRADLSGMSG;VLDFCHVIWVFMA;YKKKKFPFGYIEDLK 4 12.5 0.9974 -0.089996 0 0 0 0 0 6.75636 0 9.21871 0 0 0 0 10.5094 0 6.25414 A0A8C0T2Y3 A0A8C0T2Y3_CANLF Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) DEUP1 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535] centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536] HYLLEEEKRAKE;IDELQRHTE;KAQFSKLTNSFE;LQELMEQIDIMVSNKKLDW;QETNQIQQFLD;SEITDVKSM 6 10.6 1.0029 -0.98432 0 0 0 0 11.289 0 0 11.133 0 7.99152 0 0 0 0 0 A0A8C0T2Z6 A0A8C0T2Z6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EKKKKKRRKEEKKKKKKKKGRKEER;KEEKKKKKRRKEEKKKKKKKKGRKE;KERKKGRKKKGRKERK;KGRKEERKKGRKKRKK;KKKKKKKK 5 8 0.8587 0.16954 0 0 6.14784 0 0 0 0 5.78348 0 6.42033 0 3.74168 0 0 0 A0A8C0T300 A0A8C0T300_CANLF Uncharacterized protein LOC488622 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; cellular response to interferon-beta [GO:0035458] cytosol [GO:0005829]; nucleoplasm [GO:0005654] double-stranded DNA binding [GO:0003690] PGVACVNK;VQPHLEMEGEYKKIILLKGLEPI 2 5.8 0.99216 -0.14169 0 8.07071 0 0 0 7.72253 0 0 0 0 7.89318 0 0 0 0 A0A8C0T302 A0A8C0T302_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] ALFAAAGR;AVYYPAASPG;CAFAPAGA;GGGGGGGG;GVPAEAAGRGAGG;PAGAPAAP;VYYPAASPGP 7 15.1 1.0035 -2.0609 8.91695 0 8.43054 0 0 0 0 0 0 9.36321 0 0 0 0 0 A0A8C0T304 A0A8C0T304_CANLF "Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (Cholesterol desmolase)" CYP11A1 Canis lupus familiaris (Dog) (Canis familiaris) C21-steroid hormone metabolic process [GO:0008207]; cholesterol metabolic process [GO:0008203]; hormone biosynthetic process [GO:0042446]; steroid biosynthetic process [GO:0006694] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; steroid hydroxylase activity [GO:0008395]" LQLVPLLKASIKETLRLHPIS;REMGSQKIHYHQVQNF;VLLKKSGA 3 8.7 1.0029 -1.008 0 0 0 3.9472 0 0 0 0 10.545 0 7.4446 0 0 0 0 A0A8C0T305 A0A8C0T305_CANLF Band 7 domain-containing protein STOML1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] VGSTPREPRALIQVPDAPQSWP 1 5.9 0.97513 0.046969 0 7.30551 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T308 A0A8C0T308_CANLF BCL6 transcription repressor RTP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" EYSDSSCENGAFFCNECDCR;NHVSKKQNHFI;PQKSDCQPNSPTESCSSKN;YSDSSCENGAFFC 4 7.3 0.98623 -0.42654 9.24155 9.5191 9.68345 6.47625 0 7.75995 9.63746 0 0 0 9.39812 0 9.38834 9.44532 0 A0A8C0T309 A0A8C0T309_CANLF Latent transforming growth factor beta binding protein 3 LTBP3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AAGLLALLLLLLLLLLG;ENTRGGYRCAC;GPAPSQHLLPHPKPQH;LALLLLLLLLLLGP;LLALLLLLLLLLLGPGGGAEGG;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LTFDDCCCRQ;PLLLGKPPREED;QPGYECYCKQ;RCTCAQGYAP;RTQCIADKPEEKSL;SEEDSDECRCVS 14 9.5 1.0025 -1.7693 0 3.89811 0 8.198 0 8.8752 0 0 10.7124 4.54028 5.09635 0 12.7955 5.76808 0 A0A8C0T317 A0A8C0T317_CANLF SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 SMARCAD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] chromosome [GO:0005694] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ubiquitin binding [GO:0043130] AHLIQILLKKQ;DLSSDSEDIVSPNCSSTV;EPYEEDEFNDD;KSADEQSIYEKERIAHA;LKVLCYYGSQ;LSEDLIWHC;MDGAIAAALLMF;PEDSSVPETTENER;VGSSLDEDYSSGEEVMEDGY;VLLKHHQHR 10 13.1 1.0039 -1.6786 0 0 0 5.85912 8.33566 7.97911 12.6504 0 8.9377 0 9.19618 8.45779 0 0 0 A0A8C0T329 A0A8C0T329_CANLF Lethal(3)malignant brain tumor-like protein 2 L3MBTL2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] ATKKKKKQFGKKRKRIPPTKTRP;CSRSYSSN;EDGDSDDDFWCHMWSP;ELTGYQLQ;FDGWDSEYDQWVDCESPD;GFENDASHDFWC;KAKEATKKKK;KKKKKQFGKKRK;KKKQFGKKRKRIPPTKTRPL;PTKKAKVLH;SDDDFWCHMWSPL;TDWKGYLMKRLVG 12 16 1.003 -2.4876 0 8.10899 8.32966 8.34691 3.5846 6.46107 3.93112 0 11.6396 8.81599 0 0 5.87956 11.4253 0 A0A8C0T335 A0A8C0T335_CANLF Transporter Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] GSLIFVRPS;KVVLIILITITIL;VGICVSLFLGSL 3 4.5 0.94994 0.059561 0 0 0 0 0 4.37358 0 0 0 0 0 0 0 0 0 A0A8C0T337 A0A8C0T337_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AELDALREL;SVCGEPRGGATYPA 2 9.8 1.0022 -0.68859 0 0 0 0 0 0 8.32859 0 0 0 0 8.91319 0 0 0 A0A8C0T342 A0A8C0T342_CANLF "RAB17, member RAS oncogene family" Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVVVMLVGNKTDLG;GVLRAIWRLLRL;SGSVGKSS;VVMLVGNKTDLGEQ 4 10.2 0.94787 0.05044 0 0 6.87209 4.57386 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T346 A0A8C0T346_CANLF Zinc finger C2HC-type containing 1A ZC2HC1A Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AADRHINFCKEQAARISNKGKF;RRRRRRRREG;SRGAGGGG;VGELLPCKIC 4 13.8 0.98968 -0.21263 0 0 0 0 0 0 8.81186 8.97243 0 0 0 0 0 0 9.24864 A0A8C0T353 A0A8C0T353_CANLF DnaJ heat shock protein family (Hsp40) member B7 DNAJB7 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082] WVTSNWNPSIFSAGFKE;YSPKSYSPKHATQYTF 2 10.7 0.98782 -0.47104 0 0 0 0 0 0 0 0 0 11.759 0 0 0 0 0 A0A8C0T375 A0A8C0T375_CANLF Methylosome subunit pICln Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] CSWQDIHLSWLDGSGLGFSLEY;DIHLSWLDG;LHDEDSDDYDGE;LHDEDSDDYDGEEYDVE 4 23.2 0.98749 -0.3614 0 0 9.63811 0 0 0 0 8.29218 0 0 0 0 0 7.06361 0 A0A8C0T383 A0A8C0T383_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ENNEIQSPEETE;PAEVGPEKDQGSPSQTQGTP;TELTYTCSDERSE 3 11.3 0.98649 -0.42773 0 10.3773 0 0 0 0 0 0 0 14.9775 0 0 0 0 0 A0A8C0T388 A0A8C0T388_CANLF Methyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EGACHALEEYAERLQK;FTDNLWGTLPC;LLGMPGEGEVV;PRLPTAGKGPRVG;PSEFLENPSQSSRLTAPFRKHVR 5 14 0.98695 -0.3836 10.0367 11.0416 0 0 0 0 0 0 0 0 0 0 0 7.97039 0 A0A8C0T396 A0A8C0T396_CANLF Lactotransferrin LTF Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376]; ossification [GO:0001503]; proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type peptidase activity [GO:0008236] EQRKCEQWVRASGGSVSCV;LFNQLGSCKFDEFF;VGEAEQRKCEQW 3 5.2 0.99647 -0.11322 0 7.80484 8.88524 0 0 0 0 0 0 0 0 0 9.32096 0 9.42055 A0A8C0T3B2 A0A8C0T3B2_CANLF Neurexin 3 NRXN3 Canis lupus familiaris (Dog) (Canis familiaris) DSCANQGVCMQQWE;GFTCDCSMTSYSGNQCNDHSSE;GLILPTELWTAMLNYG;VITRDNSN 4 6.8 0.97426 0.046699 0 0 0 0 0 0 0 0 0 0 0 0 0 3.66982 0 A0A8C0T3C0 A0A8C0T3C0_CANLF "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (EC 2.7.1.159) (Inositol 1,3,4-trisphosphate 5/6-kinase)" Canis lupus familiaris (Dog) (Canis familiaris) inositol trisphosphate metabolic process [GO:0032957] "ATP binding [GO:0005524]; inositol tetrakisphosphate 1-kinase activity [GO:0047325]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]" AAGGGGGG;AGPGCCGS;DWSGRHHVIP;GGGGGGGG;GGVGGGGG;GPDPPWTSEADAGGMGAGGT;NLSRPIEEQGPLDVIIHKLTDVILE;SEGEESWLLAEREENQEAEFP;SGDDTMRLLEQN;VIDINAFPGY 10 17.8 0.99183 -0.27072 0 0 0 0 0 0 0 0 7.4847 0 0 0 0 0 0 A0A8C0T3C5 A0A8C0T3C5_CANLF Chromo domain-containing protein CDYL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription corepressor activity [GO:0003714] DTWEPEHHLLHCEE;ENGDAGSEKDERHF;GVNHGALAENGLGSA 3 9.4 0.99794 -0.097813 0 0 0 0 0 7.0278 0 0 0 10.6935 0 0 0 0 9.58731 A0A8C0T3D0 A0A8C0T3D0_CANLF Serpin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EANGTFAIRLLKM;GAAPGGGR;VLVNAIYFKGRWNEQF 3 4.4 0.91572 0.11171 0 0 0 0 0 0 0 0 7.08119 0 0 0 7.44045 0 0 A0A8C0T3D4 A0A8C0T3D4_CANLF Ankyrin repeat and sterile alpha motif domain containing 6 ANKS6 Canis lupus familiaris (Dog) (Canis familiaris) determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822] ciliary inversin compartment [GO:0097543] ENGPGSTRGDKED;EPGAAEPAERSAEPEAGAEPAGA;VAPTVKENGPGS 3 4.8 0.99178 -0.20761 0 0 0 0 0 2.56835 0 0 0 10.1228 0 0 0 0 0 A0A8C0T3D5 A0A8C0T3D5_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MYLIP Canis lupus familiaris (Dog) (Canis familiaris) cholesterol homeostasis [GO:0042632]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KSSESSMNCTSCEG;PCGHTVCCE;VLQIVSAMENYG;YQVLQIVSAMENYGIE 4 8.8 1.0028 -0.9855 0 8.85222 0 0 12.3478 0 0 9.64052 0 0 6.0974 0 0 0 0 A0A8C0T3D7 A0A8C0T3D7_CANLF Solute carrier family 41 member Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion transport [GO:0015693] plasma membrane [GO:0005886] inorganic cation transmembrane transporter activity [GO:0022890]; monoatomic cation transmembrane transporter activity [GO:0008324] FIIFYMTAALLQVLILLYIAD;GVREEALLENGSQ;LSGISWGLYL 3 8.6 0.98608 -0.4121 0 0 0 0 8.25214 0 0 11.698 0 0 0 0 0 6.95536 0 A0A8C0T3E4 A0A8C0T3E4_CANLF ABC transporter domain-containing protein ABCA12 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDALDDLVS;EQNSTSEDIRRKLC;ERLGGFDLLLKKIMAILIKR;GTYGMAAPWYFPVLPSYWKE;LEEVFINFAKD;LLVTIIILIIILK;LQNTLRNPFVQVFVKF;LSSLTVNISSCVLY;LVSVEEHLYFYARIHGI;LVTIIILIIILK;LVTIIILIIILKFGNILPKTNGFI;NVFSYHYFAALDTCLDFM;QGTMFFFLRLLINEWLIKKLRLFFR;QMNYLENITQLMP;QWENMYSSPVQDD;SIDLIDHLN;SRQSYLIGLTLL;TSEDIRRKLCESY;VEELKEELRRTTGM 19 9.8 0.97247 0.048313 0 0 0 0 0 0 0 0 0 6.848 0 0 0 0 0 A0A8C0T3F9 A0A8C0T3F9_CANLF Bromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; transmembrane transport [GO:0055085] CERF complex [GO:0090537]; membrane [GO:0016020] CARKLWIQE;KLLSEDFLPEICNMIA;PLPTNQWTEQ;SSPVAPHPPH;SYLEDIINYRWELEEGKPNP;VNLTLVTPEKAI;VVTCPMEMLK 7 4.9 1.0031 -2.0955 0 0 0 0 0 11.9452 0 10.0622 0 0 11.6863 0 0 10.8338 0 A0A8C0T3G3 A0A8C0T3G3_CANLF Intraflagellar transport protein 57 homolog Canis lupus familiaris (Dog) (Canis familiaris) EDILESTT;ELEEETVPEDDAELTLNKVDE;IGFTWKRPTYPV;SACCSPGQ 4 10.2 1.003 -2.4583 8.63187 0 0 0 0 0 0 8.47277 4.82701 0 0 0 0 0 0 A0A8C0T3H0 A0A8C0T3H0_CANLF leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) Canis lupus familiaris (Dog) (Canis familiaris) leucyl-tRNA aminoacylation [GO:0006429] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] FYVLSMFPYP;GAGAQEAVCPL;QDALADLPEWY;RGMQVINPMGWDAFGL;SLKETLRKALVPGKDCLT;SLRQNPRAP 6 7.6 1.0023 -1.7961 0 0 0 0 0 0 13.7606 0 0 11.482 0 5.43556 0 8.45964 6.54555 A0A8C0T3H8 A0A8C0T3H8_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509] LPAALGLLLLCLAA 1 3 0.93809 0.060769 0 0 0 0 0 0 7.18468 0 6.88399 0 0 0 0 0 0 A0A8C0T3I0 A0A8C0T3I0_CANLF "Vitamin D3 receptor (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] GGGGSHSS;TPSVSGDSSSSC 2 4.7 1.0043 -1.0539 0 0 0 0 0 0 0 0 0 0 0 9.66924 0 0 0 A0A8C0T3I6 A0A8C0T3I6_CANLF CN hydrolase domain-containing protein UPB1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] LAGLAHRDFGYFYGSSYV 1 4.7 0.97222 0.048313 0 0 0 0 0 0 10.2138 0 0 0 0 0 0 0 0 A0A8C0T3J0 A0A8C0T3J0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RRRRRRRRGPRRRRGAGAAPG 1 5.9 0.97652 0.047166 0 0 0 0 0 0 0 0 0 0 5.23193 0 0 0 0 A0A8C0T3J1 A0A8C0T3J1_CANLF Stathmin domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of microtubule polymerization or depolymerization [GO:0031110] AAERLQPGLRVREAAEDQRRVP;ASDLPGSSHSSPA;SGEGCRPQDEAAFPKDSR 3 12.8 0.9931 -0.1788 8.59074 0 0 0 0 9.06517 0 0 0 0 0 3.52406 0 0 0 A0A8C0T3L9 A0A8C0T3L9_CANLF mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) Canis lupus familiaris (Dog) (Canis familiaris) MAPK cascade [GO:0000165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] DIQDYDAM;ESGGGAPP;GTALALPS;NQIHLVLFGFQD;SPPGGAAG;YVSINNEAEEKTV 6 4.3 1.002 -2.61 9.27501 9.80442 0 10.2409 0 0 9.58184 7.99356 0 0 0 0 0 0 0 A0A8C0T3N1 A0A8C0T3N1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SRPK3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mRNA processing [GO:0050684]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LQTGKLSKNKRKKMRRKRKQQKRLL 1 4.4 0.97842 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.39017 A0A8C0T3R5 A0A8C0T3R5_CANLF "Membrane associated guanylate kinase, WW and PDZ domain containing 2" MAGI2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIVKLIKDAGLSVTLRI;DLKKKKKGK;EVVDILKDCPIGSETSLIIHRG;LKKKKKGKRKINFS;SQPYPAPVYSQPEELKEQMDDA;SVNDLSYYPRDHAGRP;VGDQIIEINGESTR;YRQPPLLDYRQHSPDTRQYPLAD 8 9.2 1.0021 -0.6615 0 0 0 0 4.86374 4.84152 6.66235 11.6314 0 0 0 0 0 0 9.4654 A0A8C0T3U5 A0A8C0T3U5_CANLF ATPase AAA-type core domain-containing protein IQCA1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DQIVHPQKRILIRKILD;DTEKTFYK;EEKNKKKKKKKAKKPKKPKKEK;KKKKKAKKPKKP;KKKKKKKAKKPK;KKKKKKKAKKPKKPKKEK;KKYSVKSIP;KNKKKKKKKAKKPK;KNKKKKKKKAKKPKK;KRLKKQLPKILRLLKP;KVGKKKGKKKGKKGK;LELTEFHYFDDILQ;NKKKKKKKAKKPKKPKKEKEKKE;PLTAVEFI;QEEEEKNKKKKKKKAKKP;VELELTEFHYFDDIL;VGKKKGKKKGKKGK 17 14.1 1.0034 -2.2506 7.26716 0 0 7.08757 0 7.11374 9.6335 8.74611 0 6.15923 3.892 0 10.523 6.21165 11.8532 A0A8C0T3W5 A0A8C0T3W5_CANLF TGS domain-containing protein MRPL39 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide binding [GO:0000166] MMMGCVIE 1 2.4 0.987 -0.23393 0 0 0 0 0 0 0 10.6718 0 0 0 0 0 0 0 A0A8C0T3X1 A0A8C0T3X1_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) Canis lupus familiaris (Dog) (Canis familiaris) peptidyl-prolyl cis-trans isomerase activity [GO:0003755] AGELGVRNRSWG;NLLNHNSAKIEISGFQQ;QTQKLKYHKNTRN 3 19.4 0.99393 -0.12957 9.76253 0 0 0 0 0 0 7.31061 9.09661 0 0 0 0 0 0 A0A8C0T3Y2 A0A8C0T3Y2_CANLF "Nicolin 1, tubulin polyglutamylase complex subunit" NICN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] CHVKGTVALQVGDVRTSQGR;PFELQEIMFKNYYTA 2 20 0.87648 0.12966 0 0 5.11981 0 0 0 0 0 7.86381 0 0 0 9.81574 0 12.4628 A0A8C0T3Z4 A0A8C0T3Z4_CANLF Olfactory receptor OR6K8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGNLLIFFVVRMDA 1 4.2 0.94447 0.06115 0 0 0 0 0 0 0 0 0 7.00259 0 0 0 0 8.28762 A0A8C0T407 A0A8C0T407_CANLF "GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase)" Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673] cytoplasm [GO:0005737] "GDP-mannose 4,6-dehydratase activity [GO:0008446]" DLAEYTADVD;NAYFRTSHSLSQS;QLECFSLGNLDAKRDWGH 3 5.1 0.994 -0.1198 10.8681 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T409 A0A8C0T409_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ATSAPGYARFGQG;SCYMHTST 2 5.7 0.98503 -0.25882 0 0 0 0 0 7.77703 0 0 0 0 0 0 0 0 0 A0A8C0T418 A0A8C0T418_CANLF CUB and zona pellucida like domains 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSSTTSGL 1 1.3 1.0048 -1.1044 9.71725 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6907 A0A8C0T442 A0A8C0T442_CANLF Myosin heavy chain 3 MYH3 Canis lupus familiaris (Dog) (Canis familiaris) myofibril [GO:0030016]; myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AEEDKVNSLTKI;AELEASLKESRSL;DLELTLAKVEKEKHATEN;DQVHHAVNALSKSVY;EAGELSRQLEEKES;ELTAKKRK;FYQILSNKKPLLLIT;KDEEIEQL;MVDVERANSLAAA;NTSLIHTK;PYKWLPVYNPEVVEGYRGK;RVTFQLKAERSYHIFY;TVETMQSAL;TVNPYKWLPVYNPEVVE;TVVGLYQK 15 9.2 0.9986 -3.272 0 8.27072 0 8.76404 7.32706 9.03114 6.84612 9.63014 0 0 9.50424 8.90436 8.85078 0 6.79168 A0A8C0T450 A0A8C0T450_CANLF Chromogranin-A Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation [GO:0086030]; defense response to bacterium [GO:0042742]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of insulin secretion [GO:0046676] chromaffin granule [GO:0042583]; extracellular space [GO:0005615]; transport vesicle [GO:0030133] ADGQEGLQGEDEDDDPD;LETLMTIEAE;SREDSVEASLPLQV 3 13.4 1.003 -0.86952 9.41962 0 0 0 0 0 4.62743 0 0 0 0 0 0 0 0 A0A8C0T457 A0A8C0T457_CANLF SAM-dependent MTase RsmB/NOP-type domain-containing protein NOP2 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254]; RNA methylation [GO:0001510]; RNA processing [GO:0006396] nucleolus [GO:0005730] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] DYGADSDSEGEDEDE;EDSDADMIDDYGADSDSE;EEEVEEEDSEEDGV;GADSDSEGEDED;KRQHPKKASFQ;LDFGQEGFTRFRERRF;SQPTQEIRGPKV 7 9.4 0.98995 -0.20496 0 13.4522 0 12.0753 0 0 0 4.58394 0 0 0 0 12.6861 5.85893 12.4282 A0A8C0T468 A0A8C0T468_CANLF Maestro heat like repeat family member 1 MROH1 Canis lupus familiaris (Dog) (Canis familiaris) GDGRGAAS;NIFQYFSTKD;NVLHRNIHPLL;VGAGPAGVL;YLLEFLTPTRFTGALTPL 5 5 1.0035 -0.80421 0 0 8.8088 7.24136 0 7.51854 0 0 0 0 0 0 8.13668 8.16947 8.19333 A0A8C0T484 A0A8C0T484_CANLF GST C-terminal domain-containing protein LOC477556 Canis lupus familiaris (Dog) (Canis familiaris) glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737] glutathione transferase activity [GO:0004364] PVGAGCQVFEGR;SHSLPQFRDI 2 4.4 1.0028 -0.87835 0 0 0 0 0 0 0 0 0 0 0 0 4.43216 0 0 A0A8C0T492 A0A8C0T492_CANLF Ig-like domain-containing protein LOC485809 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870] plasma membrane [GO:0005886] CTVTSVFPVGKVEWF;KDGTFNWMSWLLVNL;LETSAHQKDQCRDKNF 3 11.8 0.99296 -0.17923 0 0 0 0 0 0 0 12.5166 0 0 0 0 0 0 0 A0A8C0T496 A0A8C0T496_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] metal ion binding [GO:0046872] APSHCCLH;CEHDFQMLFAPCCGSCGE;DLLPALCL;GAPSHCCL;NALGKQWH;PPGSLLWWEG;VVNALGKQWH 7 11.3 0.99957 -0.61146 0 0 0 0 0 0 10.183 0 0 0 0 0 0 0 0 A0A8C0T4A3 A0A8C0T4A3_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] EKNKGLKETTVHGDNWQMQ;PNYLSSFSTEDFQAD;VKSDSGTGYDTDSSQ;YRLKYHQRPKLCVPETVAFV 4 6.5 0.99365 -0.074672 0 9.71894 0 0 0 8.6037 0 0 6.92041 0 0 0 8.07334 0 0 A0A8C0T4B0 A0A8C0T4B0_CANLF Cytochrome P450 2E1 (EC 1.14.13.n7) (EC 1.14.14.1) CYP2E1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743] aromatase activity [GO:0070330]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506] LDNIAVTVADLFF;SEKPCRMNSVSSVRLLMAQTGL;VLFDKQEFPDPEKFKPEHFLNENGK;YNIFPSYLHYL 4 15.8 1.0024 -1.0004 10.9468 0 0 0 0 8.47962 13.4818 12.0878 12.8151 0 0 0 0 0 0 A0A8C0T4B1 A0A8C0T4B1_CANLF "phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)" PIK3CA Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; phosphatidylinositol-mediated signaling [GO:0048015] "cytoplasm [GO:0005737]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005] DPLSEITEQEKDFLWSHRHYCVTIP;FDMVKDPEVQDFRR;FKNGDDLRQDMLT;LVRFLLKKAL;PNVESSPELPK;QLGNLRLEECRIM;WLNYDIYIPDL 7 9.9 0.98818 -0.34711 6.89579 11.0957 0 3.03429 0 0 0 4.86429 0 0 0 0 9.61526 0 11.2265 A0A8C0T4D8 A0A8C0T4D8_CANLF EMAP like 6 EML6 Canis lupus familiaris (Dog) (Canis familiaris) ATGDIFIWKD;CEGIWPAHSDVTD;EPYICIWDSYNVQTVSILKDVHTHG;KNNITKKKKL;QETQINYDRQV;RCNMEEAVRSVAF;SEESDTDAEED;VGSSEHTV;VGVKHMKF 9 5.7 1.0033 -2.1345 0 10.5257 8.77919 0 0 0 0 0 0 0 12.1025 0 0 0 9.0359 A0A8C0T4E0 A0A8C0T4E0_CANLF Ankyrin repeat domain 39 ANKRD39 ANKRD23 Canis lupus familiaris (Dog) (Canis familiaris) EALIDKYLTDGGDPS;NLVQRRREKRLKRRVPPR;PVAKPQPQAQ 3 14.1 0.99504 -0.15709 0 0 0 0 0 0 0 0 0 0 0 6.988 0 0 0 A0A8C0T4G3 A0A8C0T4G3_CANLF Coiled-coil domain containing 73 CCDC73 Canis lupus familiaris (Dog) (Canis familiaris) EIEKYYGTITGQFGSVKENHEKLER;FDPVIPQDENQSE;GQLEESCSFHIKPSGDL;LPFKQTSVFQQICN;QGQKYNLQESSNV;TEGFDLHADVQLEVEN;TEGFDLHADVQLEVENNRT 7 10 0.99647 -0.58466 0 9.38223 0 0 0 0 12.3748 0 0 5.19389 0 0 0 0 7.99571 A0A8C0T4H8 A0A8C0T4H8_CANLF Zinc finger homeobox 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]" AGDEDEEDAYSNELDDEEALGE;AVGPAQSHKR;DEEDAYSNELDDEEAL;DESQTEDS;EDEEDAYSNELDDEEA;EHQHMHFL;ESCSDESDSE;ESNVLHPN;HCKTDKHMQKYQLVAH;IEDSKESGQNAQ;KSDQSASAPMSFYP;KTDKHMQKYQLVAHIKEG;LEDLDNSLEAKAKP;LVHYNSVSHLHKLKKVLQ;QLEILYEKYLLD;QPSMMDSGSLHGISLPAAYPGLPG;QQQLGLDPGFL;QSTSKLCGTTQLDN;SEPTEAGDEDE;SLAFKTMQKLQI;SPLISAEDGGESPQKYIYF;SSNTYPHLSCFSMKSWP;TDDPDDNADRSESSSIADPSS;VGLKKRVVQVWFQNT 24 8.4 0.99691 -4.6334 10.1402 11.5573 11.5865 0 6.60669 8.8098 10.3211 8.94322 8.83321 0 10.7332 4.54517 10.4964 0 8.93201 A0A8C0T4I4 A0A8C0T4I4_CANLF ABC1 atypical kinase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GAVYQNIYGASL;GLCSFNHLLPP;LVELMHPSFGFSWVLQD 3 7.6 0.99168 -0.19424 9.26045 0 0 0 0 0 0 0 0 0 0 12.2816 0 0 0 A0A8C0T4K0 A0A8C0T4K0_CANLF PHD-type domain-containing protein PHF21A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] histone deacetylase complex [GO:0000118] chromatin binding [GO:0003682]; metal ion binding [GO:0046872] CTPPANAATSTPAHSP;EQLRKNLIVK;QEQPDKFQIQP 3 6.2 1.0031 -0.86049 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.67712 A0A8C0T4K9 A0A8C0T4K9_CANLF Mannosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] AAGAAGGC;ALLPAGHG;APPRRQPADKAGAPG;GAHAGLHAPPHGGGPRAPG;NGAWRYVAAP 5 9.3 1.0032 -2.4073 0 10.2158 0 6.02662 7.20623 0 0 9.40216 0 0 0 0 0 0 0 A0A8C0T4L7 A0A8C0T4L7_CANLF C-Maf inducing protein CMIP Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] GNLENLSLAFTNVTSACAEHLI;SEARLKSVVVASSEI;VIHPYPAPPSI;VLNLCETPVTDAG;VQLLSWENAPKYC 5 9.3 0.99433 -0.17301 0 4.99973 0 0 9.83417 0 12.1313 0 8.34603 0 9.41215 0 0 9.83692 5.03606 A0A8C0T4L8 A0A8C0T4L8_CANLF Tumor protein D52 Canis lupus familiaris (Dog) (Canis familiaris) VDCREMEFYEDYQSPFDFDT 1 8.9 0.98491 -0.25875 0 0 0 0 0 0 0 0 7.64176 0 0 0 0 0 0 A0A8C0T4L9 A0A8C0T4L9_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) ACVR1B Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363]; nervous system development [GO:0007399] activin receptor complex [GO:0048179] "activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]" EDPSCEMC;IKLALSAASGLAH;LDMEDPSCEMCLSKD;PVFLLFLIIIIVFL;PVFLLFLIIIIVFLV;TSSDLCLFFFFFFP;VGIIAGPVFLLFLIIIIVFLVI;YDLVPSDPSIEEMRKVV 8 15.7 0.93615 0.060949 0 0 0 0 6.70487 0 0 0 0 0 0 0 0 0 0 A0A8C0T4M2 A0A8C0T4M2_CANLF Ras-associating domain-containing protein RASSF10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AEIQEELNQRWMRRRQEELAAREEP;DEEAAAAAPADGEAQAA;GRRRGAAGDSP;VLLEDGCRRRR 4 12.9 0.99811 -0.098037 0 14.0238 0 0 12.1873 12.1235 13.553 10.0158 8.1877 0 3.06889 0 13.8442 13.7357 0 A0A8C0T4M8 A0A8C0T4M8_CANLF "phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" GPASSSSSSSSSSSAAQPP;GPPALSPQPYCAP;LLLLLLLP;LPALPAAQPPPPLP;NLDGKLHQH;PPPRPRLPLLLLPRLLPLLPA;SLLLLLLPGP;SPLLLLRK;SSSSSSRGPASFSASS 9 14.7 1.0032 -2.0911 0 0 0 0 8.06958 0 0 8.29967 0 6.87725 0 0 0 0 9.9857 A0A8C0T4N2 A0A8C0T4N2_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDEDEEEE;EDGCSGRVELWHAGSW;GPTVSGTPALEEEYD;GVSEKMTQDSREPLN;VGIWPDAFHC 5 6.2 0.99779 -0.10379 0 8.88286 0 0 0 0 0 12.4661 0 0 0 10.3242 8.95277 0 0 A0A8C0T4N4 A0A8C0T4N4_CANLF ADAMTS like 1 ADAMTSL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] GVSAIVNSS;MVTSWSACTRSCGGGV;PPAWYPAQWQ;PWYKQAQELEEGAAVS;QRMADGSFLELPE;REQFVIKLIGGNRKLVA;VEEWKCMY;VLDGTRCYTESLD 8 5.9 1.0019 -1.2721 10.0244 9.94317 0 0 0 0 0 0 0 0 10.6151 5.23921 12.5814 0 7.68075 A0A8C0T4N8 A0A8C0T4N8_CANLF Coiled-coil domain containing 141 Canis lupus familiaris (Dog) (Canis familiaris) DEVQYIIKESEELS;LEFAIKIDQA;LLHDHELLLAKLKAL;NEVTCWFQKTIRDLQ;QAYVAFLQSSEEVQEQCQGLK;RPREEAFGARCRRRPRGPERSSRWG;RRRQLDKDLKHQQQE;TRDYEDILYKVVQF;VSALDLGGSLQ 9 10.5 0.99535 -0.017462 5.38946 0 5.97113 0 0 11.5401 9.79786 9.833 11.0261 9.91479 0 0 9.52072 0 0 A0A8C0T4P4 A0A8C0T4P4_CANLF Synapsin-1 (Synapsin I) Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269] cell projection [GO:0042995]; Golgi apparatus [GO:0005794]; synaptic vesicle membrane [GO:0030672] actin binding [GO:0003779]; ATP binding [GO:0005524] NYLRRRLSDSNFMANLPNGYMT;VGGGSGAG 2 4.3 1.0037 -1.1044 0 0 0 0 0 0 0 0 6.82031 0 0 0 0 0 0 A0A8C0T4P9 A0A8C0T4P9_CANLF Thioredoxin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EIDQVARAYRVY;SEPSGKSG 2 4.1 1.0042 -1.0539 8.23477 0 0 0 0 0 0 0 0 8.5775 8.9491 0 0 0 9.09903 A0A8C0T4R3 A0A8C0T4R3_CANLF Non-specific serine/threonine protein kinase EP400 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] NuA4 histone acetyltransferase complex [GO:0035267]; Swr1 complex [GO:0000812] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; protein kinase activity [GO:0004672] DSSCDTDDFVMVP;LFCFPLESRPDPV;LLQAVKQLLELPLNLTIVSP;LTWPGGGP;PPIKPLLG;RDPSSHPRTLMPSIPTPHPET;RMDFDDFFHHPFL;RNKTLVPTIPRETSAPLRQLLLALL 8 5.7 1.0022 -0.65436 0 0 6.81121 8.32715 0 8.16466 8.60655 10.2042 0 0 0 0 0 0 0 A0A8C0T4R9 A0A8C0T4R9_CANLF P2X purinoceptor P2RX2 Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] EPTTHSPSCC;VIVVKNRRLGVVYRAVQLLI 2 6.8 0.98866 -0.22615 0 8.72577 0 8.16279 0 0 0 0 0 0 0 3.72792 4.25822 4.53761 0 A0A8C0T4T2 A0A8C0T4T2_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ATSAPGYARFGQG;CSHNGWNSHNCRHSED;NEPGVVEGEV;QVPILRWQFQLP;SEDAGVIWTES 5 8.6 0.98956 -0.21922 0 0 0 0 0 0 0 7.82477 0 0 0 0 0 0 0 A0A8C0T4Y6 A0A8C0T4Y6_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APSTRHSAPGT;AYVFITYDDYDHFFEDV;ILLLVFVTEVVVV;PALGTQHR 4 6.1 0.98882 -0.26431 0 0 8.34594 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T4Y9 A0A8C0T4Y9_CANLF "Rabenosyn, RAB effector" Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] PEVLQSKQLQ;VLDEKDDDRIRCCTHCKDTLLKREQ;VLDTALAD 3 5 1.003 -1.7193 6.25106 0 0 0 0 10.4482 0 0 0 0 0 0 0 0 0 A0A8C0T4Z4 A0A8C0T4Z4_CANLF Calmodulin regulated spectrin associated protein family member 3 CAMSAP3 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection development [GO:0031175] microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; spectrin binding [GO:0030507] CVASASGRT;DEGDGSPP;DGSPPGAEDSLEEEA;EELTRLAGYGPRTVT;GAEHVPSELWEPFYTD;GGGGGGGG;GGGGGGPG;GQGEPSPRPKAVTFSPELGP;IHNALSHCCLAGK;LSSEMSELGARLEEK;NALSHCCLAGKVNEPQKN;PPPEPGDLPTIE;PVEEEVGPRRGDFTRLEYERRAQ;STGSLKSSPS;VDVVMGDPVL 15 13.1 0.99746 -3.4164 8.25545 0 11.0196 0 3.62258 3.16612 11.9388 10.6355 9.88489 10.5427 0 10.1073 9.26118 9.84314 9.40293 A0A8C0T4Z5 A0A8C0T4Z5_CANLF Rap guanine nucleotide exchange factor 3 RAPGEF3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] HLVCDAVSPSR;LVENLINFEKMRMMAR;NTAGPRQAAAHWQSPPL;QEHSTYICNKRQQI;SQWVALYG;TVALRKPP;VLERASQGAGPSRPPTPGRNRYTVM;WKGSVNVVTHGKGL 8 10.9 1.0026 -1.1816 0 0 0 8.83308 0 10.5336 7.59403 6.79922 0 10.939 0 0 0 9.88018 0 A0A8C0T501 A0A8C0T501_CANLF HAT C-terminal dimerisation domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] LATEDNLEFVD;RGSSRSLL;RRFMAQVNPCYQV;SPDQSEVGQPSKSKK;VSDCSLPPSPSPHSPKTMCMG 5 6.3 0.93873 0.059747 0 0 0 0 9.37981 0 0 0 0 0 0 0 0 0 0 A0A8C0T502 A0A8C0T502_CANLF Carboxylic ester hydrolase (EC 3.1.1.-) Canis lupus familiaris (Dog) (Canis familiaris) carboxylic ester hydrolase activity [GO:0052689] APVYFYEFQHQPSFFKDI;HVEGTDVG;PMSQGLFHRAIMES 3 7.3 1.0017 -0.99513 0 0 0 9.21917 0 0 0 0 0 0 0 9.59079 0 0 0 A0A8C0T510 A0A8C0T510_CANLF Dynein light chain Tctex-type 4 DYNLT4 Canis lupus familiaris (Dog) (Canis familiaris) DEARLAGPGPS;RGSVLGPA;VLGPASSF 3 10 1.003 -1.6663 0 0 0 0 0 0 0 8.15482 0 0 0 6.39779 0 0 0 A0A8C0T518 A0A8C0T518_CANLF Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein PLPP3 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] membrane [GO:0016020] phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392] LVRTTSGQALYLHSQGSR 1 6.2 0.95779 0.051038 0 6.70736 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T519 A0A8C0T519_CANLF NPC intracellular cholesterol transporter 1 NPC1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol transport [GO:0030301] membrane [GO:0016020] lipid transporter activity [GO:0005319] FLLMFFGAFFAVWCYRKRYFVSE;GDTGESCCDALGAAF;IIDDTIFN;QASESCLFRFFKNSYSPF;SLSMPDDSYMMD;VAPSMFLS;YYVGESFANAMYN 7 7.6 0.9539 0.053903 0 0 0 0 0 4.2871 0 0 0 0 0 0 0 0 0 A0A8C0T524 A0A8C0T524_CANLF DDB1 and CUL4 associated factor 12 like 2 Canis lupus familiaris (Dog) (Canis familiaris) Cul4-RING E3 ubiquitin ligase complex [GO:0080008] LRKKQRRRATRRSL 1 3.3 0.94038 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 7.95332 0 A0A8C0T534 A0A8C0T534_CANLF Ig-like domain-containing protein ESAM Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] ERAPPSAQVF;VGVHQWGHIK;VTSARALR 3 6.3 1.0038 -0.82949 8.21956 0 0 7.35103 14.3596 0 0 0 0 0 0 0 0 0 0 A0A8C0T536 A0A8C0T536_CANLF Fibronectin type-III domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCLCCLCCRCCCC;CCLCCRCCCC;CGCCLCCLCCRCCCC;CGCCLCCLCCRCCCCA;CGCCLCCLCCRCCCCAT;EVVPPAQTPGDF;GVLLLWGLFL 7 5.2 1.0039 -0.81474 6.60579 4.77779 0 8.33749 0 0 10.0778 8.56297 8.73985 6.9847 5.07022 0 0 9.09945 8.73135 A0A8C0T547 A0A8C0T547_CANLF VWFA domain-containing protein COL6A6 Canis lupus familiaris (Dog) (Canis familiaris) GVAGDRGASGP;GVRIISVGLQSASE;KTEFNLTTYNSKRLMKRHMEQSVQQ;LWDAFQNK;PTELVFALDQSRDVTKQ;PVELLAMAGSSDKYFFVE;SKRLMKRHMEQSVQQLNGDA 7 4.3 0.98801 -0.37665 10.4141 8.32463 0 0 0 0 0 8.31945 8.82008 0 0 0 0 0 9.49011 A0A8C0T551 A0A8C0T551_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] CSHNGWNSHNCRHSED;FEGMWCTVCDDFGDEK;ISPEHNWPQLQ 3 4 0.98931 -0.51939 0 0 0 0 0 0 0 8.92014 11.3497 0 0 0 0 0 0 A0A8C0T553 A0A8C0T553_CANLF inorganic diphosphatase (EC 3.6.1.1) Canis lupus familiaris (Dog) (Canis familiaris) phosphate-containing compound metabolic process [GO:0006796] mitochondrion [GO:0005739] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] GKPENQFAFNGEFKNKAF;PGYLEATLNWFRFYKVPEG;STENLFNMVV 3 14 0.99935 -0.61146 0 0 0 0 8.32418 0 0 0 0 0 0 0 0 0 0 A0A8C0T554 A0A8C0T554_CANLF Glycosyltransferase 2-like domain-containing protein GALNT9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSVYCRLQDRS;LVDREAILQRLD;VARKIKTLLTV 3 8.9 0.99276 -0.1764 0 0 0 4.69983 0 4.44612 9.80038 0 0 0 0 0 5.37886 0 0 A0A8C0T559 A0A8C0T559_CANLF Guanine nucleotide-binding protein-like 3 GNL3 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] GTP binding [GO:0005525] EAWEAPPEESQADGSAP;ISDKMAEEEDDAYDF;KDKGKIIKHLKVRKRT 3 8.7 0.99455 -0.15512 0 0 0 9.14784 0 0 10.3595 6.34113 0 0 0 0 0 0 0 A0A8C0T583 A0A8C0T583_CANLF Zinc finger protein 282 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DSMEGELGLDSG;GAGPKPDA;GLDSGPSDSLLLVKNP;LPTAEISLW;PGGGGGGCGSCC;QVEPREEPCVWEQ;RRPMPFQFPPF;SLLLVKNPPPAPQQP;VHSGGPGLGAPRPLQ 9 14.9 0.93352 0.068575 12.0933 12.6817 12.4614 11.7003 11.8336 11.7042 12.9618 12.1544 12.2411 11.1404 8.61394 5.52105 0 0 11.7962 A0A8C0T593 A0A8C0T593_CANLF Synthesis of cytochrome C oxidase 1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] RWPVPRLFWPEQEECRNRWLHCR 1 5.7 0.97964 0.046253 0 0 0 0 0 0 8.93796 0 0 0 0 0 0 0 0 A0A8C0T5A3 A0A8C0T5A3_CANLF Sodium channel protein SCN10A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] DEAFVEFMV;IGRILRLIRAAKGIRTL;LDLKACNQLPKFY;LPTGELAPGGIEVSAF;LVMFIYSIFGMA;PGSGHGEDGH;QETLEMLQKEQEVL;TLFRVIRLARIGRILRLIR;VIRLARIGRILRLIRA;VLRALKTVSVIPGLKVIVGALI;WVAYGFKKYFTNAWCWLDFLIVNI 11 7.5 0.99401 -0.16129 0 11.3627 0 11.7745 11.2225 6.47718 8.83166 8.9661 12.4787 11.964 11.9507 0 4.61553 0 0 A0A8C0T5A6 A0A8C0T5A6_CANLF Proline rich 32 Canis lupus familiaris (Dog) (Canis familiaris) GMPAPAPS 1 2.7 1.0037 -1.1044 0 9.93404 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T5A9 A0A8C0T5A9_CANLF cathepsin X (EC 3.4.18.1) CTSZ Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] GPLLRLLLLGLLAGAPRGLLLR;KFNQCGTCT;LLRLLLLG;LLSVQHVLDCAN 4 14.3 0.97259 0.046699 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.68546 A0A8C0T5B4 A0A8C0T5B4_CANLF Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell division [GO:0051301] cell cortex [GO:0005938]; centrosome [GO:0005813]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634] G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] AGGFGVGGG;APYSPASSPPSL;DRIAQPNYIPTQQDVLRTRV;GVQACFNRSREYQLNDSAAYYLNDL;HFKMFDVGGQRSERKKWIHCFEGV;SPSPVLPL 6 13.2 1.0027 -1.4058 0 10.9201 0 7.51207 0 9.55005 0 10.2073 10.1635 7.52199 0 9.5019 0 0 0 A0A8C0T5B8 A0A8C0T5B8_CANLF BRCA1 associated ATM activator 1 BRAT1 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; DNA damage response [GO:0006974] AAGQLLVHI;AAGQLLVHIL;AAGQLLVHILG;CGLWETLAQTLN;LVPSVGLGRPGR;TASSSGSL 6 4.2 1.0031 -1.7296 0 11.5933 0 0 0 12.8453 11.0373 11.3567 12.7444 11.0636 0 0 0 0 0 A0A8C0T5C2 A0A8C0T5C2_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925] metal ion binding [GO:0046872] APSHCCLH;CEHDFQMLFAPCCGSCGE;DLLPALCL;ESILKISVS;GAPSHCCL;IVNSNGELYHE;NALGKQWH;VVNALGKQWH 8 15.3 1.003 -2.2632 0 0 12.198 11.4686 8.59455 0 11.9048 9.00745 8.70594 11.5575 0 0 0 10.9509 10.1371 A0A8C0T5C6 A0A8C0T5C6_CANLF Mitogen-activated protein kinase (EC 2.7.11.24) NLK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] DFEPITNPKFDDT;FILEQQKGNRVPLCINP;RYHTCMCKCCFSTS 3 8.4 0.99082 -0.14704 0 0 11.0595 0 0 0 0 12.2208 0 0 0 0 0 0 8.5755 A0A8C0T5D0 A0A8C0T5D0_CANLF Brevican core protein BCAN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] FINSRYREYQWIGL;PCNYHLSYTCKMGLV;PGSSGGWDPG;TLEEAQAYCRER;VQHGIDDSSD;VYCYAEDLNGELF 6 8.3 1.0015 -0.99715 5.23293 0 0 10.2321 0 0 0 0 8.48579 0 3.94561 0 0 0 0 A0A8C0T5D1 A0A8C0T5D1_CANLF CCAAT-binding factor domain-containing protein NOC4L Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nuclear membrane [GO:0031965] KGAGGPCP;LGHELDSDPFDPEEGNPAE;QESVPLQFIPAQGLLGLQDDLCA 3 9.5 1.0036 -1.1044 8.59433 0 0 0 0 0 0 0 0 0 0 0 0 0 9.52452 A0A8C0T5D4 A0A8C0T5D4_CANLF Interleukin 1 receptor accessory protein IL1RAP Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] hydrolase activity [GO:0016787]; interleukin-1 receptor activity [GO:0004908]; interleukin-1 receptor binding [GO:0005149] KVKELKRAKTVLTV;YTVELACGFGATVLLVVILIV 2 6.4 0.94024 0.060769 0 0 0 0 0 0 0 0 0 0 0 5.85087 0 0 0 A0A8C0T5E0 A0A8C0T5E0_CANLF Jacalin-type lectin domain-containing protein ZG16B Canis lupus familiaris (Dog) (Canis familiaris) YITMISGS 1 4.1 0.98411 -0.25452 7.89075 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T5E2 A0A8C0T5E2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041] actin filament [GO:0005884]; membrane [GO:0016020] AAPLAAPLLLLLLLL;AAPLAAPLLLLLLLLLLLLRC;AAPLLLLLLLLLL;AAPPVAPLLLLLLLLL;AAPPVAPLLLLLLLLLLLL;APLAPPAPPLLLLLLLLLLL;APLCSCCCSCCC;APLLLLLLLLLLLLLL;APLLLLLLLLLLLLLLL;APLLLLLLLLLLLLLLLL;APPVAPLLLLLLLLLLLLLLLL;CCCSCCCSSIAP;CSCCCSCCC;CSSCCSPCSSAAPLSQCHQG;CYSSCCSSCC;HCCSSAAPLCSCCCSCC;HCCSSAAPLCSCCCSCCCS;HCSSAAPLCSCCCSCCCS;HCSSAAPLCSCCCSCCCSS;HSSSCSSCCSST;LAAPLLLLLLLLLLL;LCSCCCSCCC;LFLLLLLLLLLL;LLLHSSSSAPP;LLLLLLCSSAAP;LLLLLLLCCCSCCSS;LLLLLLLL;LLLLLLLLCSSCCSS;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLL;LLLLLLLLLLLLLL;LLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLR;LLLLLLLLLLLLLLLRCSS;LLLLLLLLLLLLLLR;LLLLLLLLLLLS;LLLLLLLLLLSSTAPPLL;LLLLLLLLP;LLLLLLLP;LLLLLLRLLHSSSC;LLLLLRYSCCCSSAA;LVLLLLLLH;PAAPVAPLLFLLLLLLLLLL;PAPPLLLLLLLLLLLLS;PLAAPLLLLLLLLLLL;PLAAPLLLLLLLLLLLLR;PLAPPAPPLLLLLLLLLLL;PLCSCCCSCC;PLCSCCCSCCC;PLLLLLLLLL;PLLLLLLLLLLLLL;PLLLLLLLLLLLLLLLLRC;PLLLLLLLLLLLLSS;PLLLLLLLLLLLLSSTAPPLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPLLLLLLLLLLL;PPVAPLLLLLLLLLLLLLL;PPVAPLLLLLLLLLLLLLLL;PPVAPLLLLLLLLLLLLR;PSAPPLLLLLLLLPPPP;PVAPLLLLLLLLLLLLL;PVAPLLLLLLLLLLLLLL;PVAPLLLLLLLLLLLLLLLL;PVAPLLLLLLLLLLLLLLLLRCSS;PVAPLLLLLLLLRS;SAAPLAAPLLLLLLLLLLLLR;SAAPLCSCCCSCCCSS;SAPPVAPLLLLLLLLL;SAPPVAPLLLLLLLLLLLLLLLL;SSAAPLAA;SSAAPLCSCCCSCCC;SSAAPLCSCCCSCCCSSIA;VAPLLLLLLLLLLLLLLL;VAPLLLLLLLLRS;VLLLLCSHCCSSAAPLCSCCCSCC;VLVLLLLLLH;YSSCCSSC;YSSCCSSCC 84 31.7 0.99687 -5.6154 10.6615 10.7066 11.6667 11.003 10.4017 10.5717 11.8796 12.1211 11.8597 11.2879 10.7968 10.342 9.80402 11.498 11.153 A0A8C0T5E4 A0A8C0T5E4_CANLF Caseinolytic mitochondrial matrix peptidase chaperone subunit B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ALQLRQEALEM;ARHRLGWTALMVA;QSLEASTWGRLPSPEET;SVITAGRGEPQW;VHYGARSIKHE;YAVLADDY 6 10.5 1 -0.61576 0 6.99537 0 0 0 0 9.24505 7.33834 12.1829 8.02912 9.12518 6.86888 0 0 0 A0A8C0T5I7 A0A8C0T5I7_CANLF Sodium/calcium exchanger membrane region domain-containing protein SLC24A2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane transport [GO:0070588] membrane [GO:0016020] antiporter activity [GO:0015297] IPTSGCQQ;KKLKLIRILGLL;KLKLIRILGLL;RKKLKLIRILGL;RKKLKLIRILGLL;RKKLKLIRILGLLMGLVAI;VIMWWESL;WESLLLLTAYFGYVVFMKFN 8 8.3 1.0027 -1.3876 5.74868 4.75756 6.55324 5.8651 5.94399 4.06143 0 0 11.5476 4.6416 5.71009 0 0 5.18484 0 A0A8C0T5J0 A0A8C0T5J0_CANLF Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC 2.7.11.10) (Nuclear factor NF-kappa-B inhibitor kinase alpha) CHUK Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APELFENKPYTATVDYW;ELSTKNRERWCHEIQ;HRELDVKIAIK;LQPFTWHEKIKKKDPKCI;VGSSLEGAVTPQ;VGSSLEGAVTPQASAW 6 10.4 1.0026 -0.97293 0 8.60947 0 0 10.2737 8.6755 10.1444 0 0 0 0 0 0 0 0 A0A8C0T5J4 A0A8C0T5J4_CANLF Zinc finger protein 777 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SESLETPEPLMG 1 1.5 0.94531 0.05044 0 0 0 0 0 0 0 0 0 0 0 9.5503 0 0 0 A0A8C0T5K4 A0A8C0T5K4_CANLF Homeobox protein MOX-1 (Mesenchyme homeobox 1) MEOX1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] PSAQCSGSPLWLY 1 4.9 0.9398 0.059608 0 0 0 0 0 0 0 0 5.13603 0 0 0 0 0 0 A0A8C0T5L4 A0A8C0T5L4_CANLF Modulator of VRAC current 1 MLC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SHKTWVLSVLMGSCLLVTS;TGHRSSLPS 2 5 1.0025 -0.75435 0 0 0 0 0 0 0 0 0 0 0 8.92633 0 8.81137 0 A0A8C0T5N4 A0A8C0T5N4_CANLF TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) TYROBP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PVVSPGVLAGI 1 10.8 0.98223 -0.24839 0 0 0 0 0 0 0 10.0672 0 0 0 0 0 0 0 A0A8C0T5P2 A0A8C0T5P2_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKZ Canis lupus familiaris (Dog) (Canis familiaris) "diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]" nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] APSATTSWRLGP;DLPTPTSPLPTSPCSPTL;ESATYGEHIW;NIREPTFVRHHW 4 5 0.98422 -0.25442 8.30278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T5S4 A0A8C0T5S4_CANLF Cyclic nucleotide-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated potassium channel activity [GO:0005249] FLDLASLMPTD;GYSDLFCL;QEEEYLFMVGD 3 5.2 0.9894 -0.19707 0 0 0 0 0 7.87301 6.03617 0 0 0 0 9.95656 0 0 0 A0A8C0T5S8 A0A8C0T5S8_CANLF Clathrin heavy chain linker domain-containing protein 1 CLHC1 Canis lupus familiaris (Dog) (Canis familiaris) AAEPTALV 1 1.4 1.0047 -1.1044 6.46336 0 0 0 0 0 6.42134 0 0 0 0 0 0 0 0 A0A8C0T5S9 A0A8C0T5S9_CANLF mRNA decay activator protein ZFP36 (Zinc finger protein 36) Canis lupus familiaris (Dog) (Canis familiaris) "3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925] AANGGSCGGGAAGGPASYGTLKE;CSPKFPGAANGGSCGGGAAGGP;DLLAPGAPCAACSSAS;GGGGGGGG;NGGSCGGG 5 11 1.0023 -1.4462 0 0 0 0 0 0 0 0 15.3102 9.0207 0 0 8.98817 0 0 A0A8C0T5U0 A0A8C0T5U0_CANLF SAM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] GEDEEDPDEGDDDS;INGKYCCPKIYFN;SEQQDELQEESEM;VHKKKRSSASVDNTP;YDGYGEDRRADFWCDIR 5 8.3 0.97941 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0765 0 A0A8C0T5U1 A0A8C0T5U1_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] PPLRLLLL;PPLRLLLLLL 2 1.6 0.99957 -0.61146 5.21517 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T5W0 A0A8C0T5W0_CANLF mitogen-activated protein kinase kinase (EC 2.7.12.2) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] ILETWRSSYWNGVLSDFPMPEERG;KIIHRDIKPSNILLDR;SPEQHWDFTAEDL;SSPILETWRSSYWN;VLFSVGCML 5 9.2 0.68797 0.29973 6.24327 5.74559 7.40148 0 0 0 0 0 6.85848 10.7017 9.00357 0 0 0 0 A0A8C0T5Y0 A0A8C0T5Y0_CANLF PWWP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEPEPEPE;DLVFAKMKGYPHWPARI;QEEEEEEEEEEEEAAKEDA 3 18.3 0.9847 -0.25339 0 0 0 0 0 0 9.66922 0 0 0 0 0 0 0 0 A0A8C0T604 A0A8C0T604_CANLF TAFA chemokine like family member 5 TAFA5 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] extracellular space [GO:0005615]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; receptor ligand activity [GO:0048018] AMILMLEQILKSRQQSLRGQ 1 15.2 0.95497 0.049417 0 7.81807 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T608 A0A8C0T608_CANLF Acylamino-acid-releasing enzyme (EC 3.4.19.1) (Acyl-peptide hydrolase) (Acylaminoacyl-peptidase) APEH Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta metabolic process [GO:0050435]; proteolysis [GO:0006508] cytosol [GO:0005829]; nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; omega peptidase activity [GO:0008242]; serine-type endopeptidase activity [GO:0004252] EAGFPYSSDCLPD;YYVDLTGGQCELLSD 2 3.8 0.98712 -0.49876 11.1925 0 0 0 0 0 0 0 0 0 13.8672 0 0 0 0 A0A8C0T611 A0A8C0T611_CANLF Fibronectin FN1 Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; cell adhesion [GO:0007155]; regulation of cell shape [GO:0008360] extracellular region [GO:0005576] heparin binding [GO:0008201] APSNLRFLATTPNSLL;EATCYDDGKTYHV;GAAGAGGG;GARLRLLLLLAVPALGAALRSA;GLEPGTEYTIQ;HPIQWNAPEP;LSQTTISWTPFQESSEYIIS;PMAAHEEICTTNEGV;PPTDLRFTNIGPDTMRVTW;PTHLARSPSGALP;RFLATTPNSLL;SSKPVSIDYR;TVSDVPRDLE;VDRVDDTSIVV;YRIVYSPSVE;YSPVKNEE 16 7.5 0.9976 -3.3748 10.1283 0 9.42763 8.13981 8.0119 11.0065 9.15216 0 0 10.8145 10.6808 0 10.6961 8.68054 9.43611 A0A8C0T620 A0A8C0T620_CANLF Class E basic helix-loop-helix protein 22 (Class B basic helix-loop-helix protein 5) Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] GAGGGGGG;GGGGGGGG;GGGGGGSG;GGGGGKAA;GPTRAPAREPG;LETKKKKKRRRRARGKAK;LETKKKKKRRRRARGKAKK;PGGGGGGG;PGGPGGGG;RLETKKKKKRR;RRRRARGKAKKKKKGRGLPAAPG;VSSSLCKQCTEK 12 20.9 0.98765 -0.33509 0 0 0 8.32652 0 8.92214 8.56369 4.93588 0 0 0 0 6.21199 8.23165 9.13132 A0A8C0T623 A0A8C0T623_CANLF Programmed cell death protein 4 PDCD4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] cytosol [GO:0005829]; nucleus [GO:0005634] AALDKATVLLSMSKGGKRKDSVWGS;VGDGILCNTYIDS 2 8.8 0.99259 -0.17482 0 10.676 8.15152 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T624 A0A8C0T624_CANLF Armadillo repeat-containing protein 1 ARMC1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] metal ion binding [GO:0046872] KEQDKADRGYRWSSLFMKVFWFCFP 1 8.3 0.97848 0.035538 0 0 0 7.06329 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T637 A0A8C0T637_CANLF Bactericidal permeability-increasing protein (BPI) Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular space [GO:0005615] lipid binding [GO:0008289] MARHPDNALRWATLLVLAIL;NYVVPTAVLPKV;QEAGALNMTITDD 3 9.8 0.99729 -0.10706 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4665 7.63016 A0A8C0T644 A0A8C0T644_CANLF Sterile alpha motif domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] DDEDEDEEDD;LEKEEEEEDDEDEDEEDDVS;PEGDRPAGAQH 3 6.2 0.94261 0.083697 0 0 0 0 0 0 0 0 0 0 0 5.81834 0 0 0 A0A8C0T673 A0A8C0T673_CANLF VTT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAWVAARIQSSGR;GGGGGGGG;GGRGGGGG;RAAAAGAAPAPAARGA 4 10.1 0.98692 -0.23485 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5463 A0A8C0T676 A0A8C0T676_CANLF Cadherin EGF LAG seven-pass G-type receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] EVIQEQVQLTFSAG;EVRDVNAGPMRF;FITFRGLRQ;GALLDAANKRHW;LEVIQEQVQLTFSAGE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PGPRSATAAVFLSVED;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPPPLLLLLLLLL;PPPPPPPLLLLLLLLLL;PTCGPCNCD;SLSVGRPPGPGGGPPFLPSE;VTDTNDHD 18 4.5 0.94429 0.05044 0 0 0 0 0 0 0 11.0688 0 0 0 0 0 0 0 A0A8C0T682 A0A8C0T682_CANLF Calmodulin regulated spectrin associated protein 1 CAMSAP1 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection development [GO:0031175] microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; spectrin binding [GO:0030507] DLDEAEQDLI;DLRDPFYIDQ;DVQEPKDAKTVSH;EDLRDPFYIDQ;LKADGQSL;QLHMQLEEKR;SLYNIRLL;VGMDPVPT;VKEAGLSSPAVSG;VTDPDLSH 10 5.6 0.99703 -3.6682 0 10.0073 8.31061 0 0 0 9.93023 11.1336 12.723 10.773 9.46283 10.7875 10.9246 10.2952 7.4224 A0A8C0T6A3 A0A8C0T6A3_CANLF Membrane frizzled-related protein MFRP Canis lupus familiaris (Dog) (Canis familiaris) eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] plasma membrane [GO:0005886] CDTWRHCTDSSDDSCSSPLFPPP;CLFDRLEISPEPEG;LASLLLLLLGLLVAIILG;LLLASLLLLLLGLLVAIILGQ;PLFPPPELACEPVQVEMCTGLSY 5 12.8 0.72647 0.24925 9.26725 0 0 0 0 5.31056 5.804 5.36366 0 0 0 0 10.0315 6.1071 0 A0A8C0T6A6 A0A8C0T6A6_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] ADAYCGWCA;AEPKKSHRQ;AVHHIGREPTL;CAQQHACVSNQSRCEASP;CMYSCLRET;DIQIVSDRVIHCSV;DTEKYFHLVLPTDELA;QEGGGDGEEP;QFPPFPPHQDHVIVE;RSNLTFQYMQNPVI;SLPSLSGMEMACDY;TVHCNQVV 12 6.7 0.99714 -3.8948 0 9.03686 10.3547 5.77431 10.4125 0 6.52597 9.7857 8.59634 0 0 0 0 10.0269 9.21018 A0A8C0T6B0 A0A8C0T6B0_CANLF Little elongation complex subunit 2 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation factor complex [GO:0008023] DNSKEKTITSEP;DYMSEMDMSYE;EQRSYVDLLV;LVQDNNLKMSDSLQ;RNQIFHEVPL;SSLQEGSYL;VLKKPIKRVYK 7 8.6 1.0025 -1.8967 11.6294 10.5309 0 0 0 0 0 0 0 6.16007 0 6.84612 0 4.31897 0 A0A8C0T6D1 A0A8C0T6D1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ARQRGSGAAAAAAAGTGPG;ATPPPTTSLLPIYV;ECGNWEGGRESCHCPQ;GRGGAGAD 4 8.1 1.0016 -0.75244 8.7879 0 0 0 0 0 0 3.5368 0 0 0 7.20056 0 0 0 A0A8C0T6E2 A0A8C0T6E2_CANLF TBC1 domain family member 25 TBC1D25 Canis lupus familiaris (Dog) (Canis familiaris) ADPDFYQYLQ;FLPPEFRSFAVDPQITSLDVLQ;GVEPSLRKVVWRYLLNVY;RLGQETYLSLLSDWDLS 4 8.8 0.98781 -0.46953 8.83026 0 0 0 6.32997 0 0 0 0 0 5.09976 0 0 0 6.50034 A0A8C0T6E7 A0A8C0T6E7_CANLF Actin-related protein 5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AGPGAHGP;DWALGHLDNDEVWITRKEYEEKGG 2 5.2 1.0034 -1.0631 9.94006 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T6E8 A0A8C0T6E8_CANLF "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial respiratory chain complex I [GO:0005747] FVAFMLFMFWVGENYRTYQPVGPK 1 15.5 0.99425 -0.28539 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7726 A0A8C0T6F3 A0A8C0T6F3_CANLF Ral GEF with PH domain and SH3 binding motif 1 RALGPS1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] NCSGGTLSPCLPQGSSSSDSLEG;VGWMVQLPDDPEHPDIFQL 2 7.2 0.94315 0.083742 0 8.79058 0 0 0 0 0 10.4923 0 0 0 0 0 0 0 A0A8C0T6K2 A0A8C0T6K2_CANLF Metal transporter CNNM4 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion homeostasis [GO:0010960] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] KTVPAAGP;NKTCGMNPDGI;SPENTDLQVIPG;TQLQDCFMIRSDAILDFN;VLGQEIRTVYNRE 5 8.7 1.0042 -1.0539 8.30884 0 0 0 0 0 0 0 0 0 7.61817 0 0 0 0 A0A8C0T6K8 A0A8C0T6K8_CANLF PDZ and LIM domain 5 PDLIM5 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GEPYCETDYYA;LSSPDKYHL;MEDTEDWRPRTGTTQSRSFRILAQ;TWHDTCFVCSVCCESL 4 9.6 1.0039 -0.81428 0 0 9.01396 2.35786 0 0 0 0 0 0 0 9.47021 0 0 0 A0A8C0T6L3 A0A8C0T6L3_CANLF Jumonji and AT-rich interaction domain containing 2 JARID2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; regulation of gene expression [GO:0010468] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677] LSKRKPKTEDFL;VLSDFHKCIYK;VPERSLERNR;YTATVTKGTVTYTK 4 4.1 0.99354 -0.17035 0 0 0 0 0 8.35861 0 0 9.66037 0 0 0 0 0 8.48055 A0A8C0T6N7 A0A8C0T6N7_CANLF Neural cell adhesion molecule L1 L1CAM Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] DEYEGYRVMEP;ETFGEYSDNEEKAF;ISAIILLLLILLI;ISAIILLLLILLILCFIKR;ITEQSPRRLV;LLCKAFGAP;SSAVLVRWW;VGSPGPVP;VHFKPKEELGVTV;WFIGFISAIILLLLIL 10 8.1 0.98106 0.035491 0 0 9.15413 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T6P4 A0A8C0T6P4_CANLF Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) CHORDC1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GVIDVTRSYVTMTA;NGGCTKTYQGLQ;YWSCCRRKTSDFN 3 12.5 0.99078 -0.21005 0 0 0 0 0 8.3185 8.71572 0 0 0 0 0 0 0 0 A0A8C0T6Q5 A0A8C0T6Q5_CANLF Ammonium transporter Rh type B (Rhesus blood group family type B glycoprotein) Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] ammonium channel activity [GO:0008519] LFAMIGHACEQT;VHVMVFVGFGFL 2 4.7 0.98626 -0.41316 0 0 0 0 12.3082 9.90103 0 0 0 0 0 0 0 0 0 A0A8C0T6Q8 A0A8C0T6Q8_CANLF Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) SLC38A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LCMMFFLIVVIC;LLVSLVLILPLSLLRN;LVLLVSLVLILPLSLL;SELLHTYSTI 4 9.9 0.98749 -0.46255 0 3.73531 9.13901 0 0 0 0 5.71463 0 0 0 0 0 8.72062 3.91972 A0A8C0T6R0 A0A8C0T6R0_CANLF IQ motif containing GTPase activating protein 3 IQGAP3 Canis lupus familiaris (Dog) (Canis familiaris) ERFAMDEYSDMVAVAK;LEQLSSDREQKA;TANMKGDEEQAMFQAVCR;VAKVLRTTLA;VGNLLYYRFLNP 5 4.5 1.0028 -1.3401 0 0 0 0 0 0 0 0 8.66952 0 8.6551 0 7.78986 0 0 A0A8C0T6R1 A0A8C0T6R1_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKB Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509] CTIKITHKNQAPML;LPTSGVSV 2 2.7 1.0017 -1.309 0 0 0 9.63751 0 0 10.16 0 0 0 0 0 0 0 0 A0A8C0T6R5 A0A8C0T6R5_CANLF Nuclear RNA export factor 2 Canis lupus familiaris (Dog) (Canis familiaris) poly(A)+ mRNA export from nucleus [GO:0016973] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ALKDVSYKIF;ELKNLVLQFLQQYY;EPEEMEQLKLTMNKRYDV;IVSNVFLFQESYK;TVWRDRKNLKREVEEN;VLPYEKYKK;YERGGYEPQPSHLQE;YVLPYEKYK 8 16.6 1.0013 -1.3156 5.6577 0 0 9.13098 15.3538 0 0 0 7.98539 0 8.84947 0 0 11.0119 0 A0A8C0T6T1 A0A8C0T6T1_CANLF Tubulin beta chain TUBB1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] LVHSLGGGTGAGMG;SVLPSPKVSDTVVEPYN 2 6.8 0.99679 -0.10978 0 0 0 0 0 0 0 0 0 0 8.45306 0 0 0 0 A0A8C0T6Y1 A0A8C0T6Y1_CANLF Galectin LGALS9 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] LSPGVPFSG;QPFPNPIIPPMAYPTPT 2 8 0.99301 -0.028815 0 0 0 0 0 9.60994 0 0 0 6.41344 0 7.11759 0 0 0 A0A8C0T6Z9 A0A8C0T6Z9_CANLF Amyloid beta precursor protein binding family B member 1 APBB1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta binding [GO:0001540] EDETLKLVEPQ;EEEEEDLSSPQ;LSFLAVGRDVHTFAFI;SFCCHMFWCEPNAASLSEA;SPQGLEPPESVEVPPRPQAL;VGRDSGRERDFAYVARDK 6 13 0.98792 -0.34832 6.62883 0 10.7735 0 6.99345 0 0 9.68963 0 0 8.5985 0 0 0 0 A0A8C0T709 A0A8C0T709_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" ELEKEFHYSRYITIRRKAELAATL;TGGRKGGG 2 6.9 1.0021 -1.3953 10.4579 0 0 0 0 0 0 0 0 0 0 0 0 10.7277 0 A0A8C0T733 A0A8C0T733_CANLF uroporphyrinogen-III synthase (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) Canis lupus familiaris (Dog) (Canis familiaris) protoporphyrinogen IX biosynthetic process [GO:0006782]; uroporphyrinogen III biosynthetic process [GO:0006780] uroporphyrinogen-III synthase activity [GO:0004852] KKKKKKKK;KKKKKKKKTCELQVLE 2 10.1 0.9617 0.049233 0 0 0 0 0 0 0 0 0 7.3427 0 0 0 0 0 A0A8C0T735 A0A8C0T735_CANLF L-type lectin-like domain-containing protein CPLX3 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; neurotransmitter transport [GO:0006836] membrane [GO:0016020]; synapse [GO:0045202] syntaxin binding [GO:0019905] GILFDSSAEDTQQSPVIRV;KAERATLRSHFRDKYRL;LVASGEPLLRLALALLLLL;SLQRRFEYKLSFKGPRL 4 12.7 0.98985 -0.22034 0 0 0 0 5.95975 0 9.97828 12.7336 9.15084 0 0 0 0 0 0 A0A8C0T751 A0A8C0T751_CANLF Ectonucleoside triphosphate diphosphohydrolase 3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] EACHDQEACSFDG;GYMLSLTNQI;LVVLLLSVVVLVAITLIQ;SRKQRQSQHAFNHTV;YCFSAHYIYH 5 12.5 1.0022 -1.4472 11.6926 0 0 0 0 4.24618 6.42306 0 0 0 3.68963 0 6.77584 0 0 A0A8C0T760 A0A8C0T760_CANLF protein disulfide-isomerase (EC 5.3.4.1) Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; isomerase activity [GO:0016853] LLLLLLLP;PGAAAKKA 2 5 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 12.23 0 0 0 A0A8C0T765 A0A8C0T765_CANLF histone acetyltransferase (EC 2.3.1.48) EP300 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654] DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] DLCFFGMHVQEYGSDC;LPSAAGMVPV;PTGMQQQPQWVQGGLPQPQQ;SVSLGDDPSQPQ;VEMAMQIQ 5 3 1.002 -1.417 0 12.5758 12.5539 12.0128 12.5377 0 14.0773 13.0271 0 14.0289 13.6738 13.822 14.8745 0 11.6534 A0A8C0T775 A0A8C0T775_CANLF MADS-box domain-containing protein MEF2D Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LSLGGVTAWPQPAQQPQPP 1 3.7 0.94942 0.049902 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.46333 A0A8C0T779 A0A8C0T779_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SYSTSVGDNFALEWS 1 4.6 0.95084 0.053874 0 0 0 0 0 7.48696 0 0 0 0 0 0 0 0 0 A0A8C0T792 A0A8C0T792_CANLF Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.250) PORCN Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] membrane [GO:0016020] acyltransferase activity [GO:0016746] HVLRKRLARILS;LVPEPSPEPH;WNLPMSYWLNN 3 8.6 1.003 -0.84962 0 0 7.76248 0 0 0 0 8.89154 0 0 0 0 0 0 0 A0A8C0T794 A0A8C0T794_CANLF GEM interacting protein GMIP Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] ETPITSVTRGSLR;GFCGAGAC 2 2 0.99036 -0.26592 0 11.7881 11.6639 0 0 0 0 0 11.8362 11.5039 0 0 0 0 0 A0A8C0T795 A0A8C0T795_CANLF Rho GTPase activating protein 44 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] LLEEHLMISGREIAFPIE;SPSGLGLQPGAER 2 4.1 0.87589 0.12862 0 0 0 0 0 0 0 10.2157 0 0 0 2.93045 0 0 0 A0A8C0T7B3 A0A8C0T7B3_CANLF L-type lectin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RMLFLLLLL;VGTGSSSL 2 10.9 1.0019 -1.4651 0 0 0 0 0 0 0 9.08526 0 0 0 0 0 0 0 A0A8C0T7C6 A0A8C0T7C6_CANLF Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) ANAPC15 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid stimulus [GO:0071230]; cholesterol homeostasis [GO:0042632]; endosomal transport [GO:0016197]; lysosome organization [GO:0007040]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of receptor recycling [GO:0001919] anaphase-promoting complex [GO:0005680]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; Ragulator complex [GO:0071986] guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090] ASEHYDDEEEEDEDDDEDSEEDSE;DDEDMQDMDEM;DDEDMQDMDEMNDYN;DDEDMQDMDEMNDYNE;DDEDSEEDSEDDEDMQ;DDEEEEDEDDDED;DDEEEEDEDDDEDSEEDSEDD;DEDSEEDSEDDEDMQDMD;DSEDDEDMQDMDEMNDYN;EDDEDMQDMDEMN;EDEDDDEDSEEDSEDD;EDEDDDEDSEEDSEDDEDMQ;EDEDDDEDSEEDSEDDEDMQDMDEM;EDMQDMDEMNDYNESPDDGEV;EEEEDEDDDEDSEEDSED;KPASEHYDDEEEEDEDDDEDSEEDS;MQDMDEMNDYNESPDDGEVN;PASEHYDDEEEEDEDD;QDMDEMNDYNESPDDGE;SLTSQPHQVLASEP;YDDEEEEDEDDDEDS 21 22.3 0.2963 0.63944 8.97963 6.65048 6.91229 0 6.1611 7.44684 6.19142 6.51543 8.81769 0 7.55182 7.30168 6.88545 5.2488 6.77426 A0A8C0T7D8 A0A8C0T7D8_CANLF Amino acid transporter transmembrane domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193] IGIISVHCMHILV;IGMGIVTTLYVTLA;TLYVTLATLGYMCFH 3 7.7 1.0016 -0.69349 10.3912 0 0 0 0 0 0 12.0464 0 0 0 0 0 0 0 A0A8C0T7E0 A0A8C0T7E0_CANLF C-CAP/cofactor C-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] plasma membrane [GO:0005886] actin binding [GO:0003779] CEIVSAKSS;GVSLLILPDI 2 3.7 0.99971 -0.61146 0 0 0 0 0 0 0 4.06712 0 0 0 0 0 0 0 A0A8C0T7F7 A0A8C0T7F7_CANLF Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1) KCNE2 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] voltage-gated potassium channel activity [GO:0005249] LNLEESKTTIHENMG;QTKLDAENFYYVILYLMVM 2 27.6 0.93847 0.10378 0 0 0 0 0 0 0 0 0 0 0 0 8.97654 0 0 A0A8C0T7F9 A0A8C0T7F9_CANLF Large ribosomal subunit protein eL14 (60S ribosomal protein L14) Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; organelle membrane [GO:0031090] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FSQRACVHVRTYDPSQSALTS;KAPAAKGA 2 9.3 0.98627 -0.41321 0 12.8861 0 11.2609 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T7G5 A0A8C0T7G5_CANLF GEM interacting protein GMIP Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] ETPITSVTRGSLR;VEGGILTPLPP 2 2.4 0.99469 -0.1542 0 0 9.58099 0 0 0 0 0 0 0 0 0 0 9.56786 0 A0A8C0T7H7 A0A8C0T7H7_CANLF "FYVE, RhoGEF and PH domain containing 5" FGD5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] DEADGGTAPT;EKLVEEHNM;GVEDSACD;HVMMCMNCGC;LSSDEEQGSSEEEDS;NSMSRGPKPPIAP 6 4.5 1.0021 -2.6098 0 0 0 0 0 8.37165 4.08236 0 0 0 0 0 13.1738 0 12.5774 A0A8C0T7I2 A0A8C0T7I2_CANLF Lanosterol 14-alpha demethylase (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P450LI) Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; organic hydroxy compound biosynthetic process [GO:1901617]; small molecule biosynthetic process [GO:0044283]; steroid biosynthetic process [GO:0006694] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" AWMGFFLARDKTLQDKCY 1 3.8 0.97224 0.048313 0 0 0 0 0 0 0 9.8695 0 0 0 0 0 0 0 A0A8C0T7I6 A0A8C0T7I6_CANLF "Membrane associated guanylate kinase, WW and PDZ domain containing 2" MAGI2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIVKLIKDAGLSVTLRI;EVVDILKDCPIGSETSLIIHRG;PEDGPPPLAPSHP;SQPYPAPVYSQPEELKEQMDDA;SVNDLSYYPRDHAGRP;VGDQIIEINGESTR;YRQPPLLDYRQHSPDTRQYPLAD 7 8.3 0.93878 0.059848 0 0 0 0 0 0 5.26397 0 0 0 0 0 0 0 0 A0A8C0T7J6 A0A8C0T7J6_CANLF C-type lectin domain-containing protein CLEC4O Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246]; signaling receptor activity [GO:0038023] KTWKYLCFFVSLILLLTVIIL;LILLLTVIILSVI;PACMMMYNY;VSLILLLTVIILSVILSEVL 4 15.7 1.0022 -0.64928 8.64757 7.31841 0 0 4.49237 0 0 8.35306 5.54782 0 0 3.9944 0 0 7.82706 A0A8C0T7J9 A0A8C0T7J9_CANLF AIG1-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525] DTPSLFEAEAQTQ;VVLFTHKED 2 7.4 0.98704 -0.40692 0 0 0 0 0 10.4421 0 0 0 0 0 0 0 9.11437 0 A0A8C0T7L3 A0A8C0T7L3_CANLF Hemopexin HPX Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879] extracellular region [GO:0005576] heme transmembrane transporter activity [GO:0015232]; metal ion binding [GO:0046872] GPGLYLIHG;HPLSPDGTH;HPLSPDGTHG;LDLKLGAQAT;LDTSRDGWHSW;LQEEFPGIPSPVDA;TLDEHGAM;VDAAVECHRGECQDEG 8 16.4 0 7.2944 11.0102 11.1623 11.1148 11.0927 11.4341 11.596 11.602 11.5106 11.1399 12.1359 11.0496 11.0313 11.168 10.5109 11.3254 A0A8C0T7N5 A0A8C0T7N5_CANLF Mediator complex subunit 15 MED15 Canis lupus familiaris (Dog) (Canis familiaris) QPNSNVSSGPAPS;SPVTARTPQNFSVPS 2 4.7 0.65447 0.32248 9.15631 0 0 0 0 0 0 0 0 8.55067 8.43671 0 0 0 0 A0A8C0T7Q3 A0A8C0T7Q3_CANLF AIG1-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] RRCWSCCKEG;TFREQEPLSL;VGKRGAGK;WFTQEDKRAVKEL 4 6.2 1.0014 -0.94719 0 0 10.0104 0 0 0 13.6512 0 10.2932 0 0 13.4094 12.5925 0 12.5177 A0A8C0T7S4 A0A8C0T7S4_CANLF Fibrillar collagen NC1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; sensory perception of sound [GO:0007605] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] EEQTDLQVPSTADRFLTEEYGEGG;GDRGEVGVPGSRGEDG;GPAGPNGA;GVKGDRGFDGLPGLPG;LGLKGNEGPAGPPGPAGSPGE;PAGPYDYTYGYGDDYREE;VGPMGPPG 7 6.4 1.0009 -0.62567 0 0 0 0 0 6.96521 0 10.7081 9.31331 8.87098 7.09255 4.85634 5.96673 0 0 A0A8C0T7T3 A0A8C0T7T3_CANLF AF-9 ANC1 homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] transcription elongation factor complex [GO:0008023] chromatin binding [GO:0003682]; lysine-acetylated histone binding [GO:0070577] EAEDNDNDSEME;FDFDLCSLDKTTVR;KPDSNLLTIT;SLSDGSDS;VELHRRLMTLRER 5 10.1 1.0034 -1.5472 0 5.37993 0 8.74046 0 0 0 0 0 0 0 0 6.91958 5.14564 0 A0A8C0T7V5 A0A8C0T7V5_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GDMVCAGNP 1 3 0.98954 -0.26542 0 0 0 0 0 0 0 7.37764 0 0 0 0 0 0 0 A0A8C0T7W9 A0A8C0T7W9_CANLF Transmembrane protein 207 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EENEMCVN 1 5.6 0.98972 -0.26592 0 0 0 8.56281 0 0 0 0 3.0031 0 0 2.58559 0 0 0 A0A8C0T7X1 A0A8C0T7X1_CANLF Myb-like domain-containing protein TERB1 Canis lupus familiaris (Dog) (Canis familiaris) meiotic attachment of telomere to nuclear envelope [GO:0070197] NEELNKAATFVLHNCKK 1 2.4 0.98675 0.046227 0 0 0 0 0 0 0 0 6.70293 0 0 0 0 0 0 A0A8C0T7Y2 A0A8C0T7Y2_CANLF Leucine rich repeat containing 14B LRRC14B Canis lupus familiaris (Dog) (Canis familiaris) LRLAGPGELHRL 1 2.4 0.94182 0.05044 0 0 6.59926 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T7Y5 A0A8C0T7Y5_CANLF CCHC-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) virion assembly [GO:0019068] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] DIQILLNVFLTSEERS;EDSLSTRLNTATPPP;YRRCILRGLRNGV 3 8.7 0.98922 -0.19968 0 0 0 0 0 0 0 0 0 11.955 0 8.12572 0 0 8.08651 A0A8C0T7Z7 A0A8C0T7Z7_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ADLRSHFQKYQVSEISIYDSSTNY;KETAEDVQKHDTDEDSQ;QLGSEQDNEFFPFDQ;SSKPNGNFLNKDS 4 7 0.98641 -0.41156 0 6.1099 0 0 10.5977 0 9.04095 0 0 0 0 0 0 0 7.182 A0A8C0T802 A0A8C0T802_CANLF Semaphorin-3C SEMA3C Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor binding [GO:0030215] KQQLYVSSNEGVSQVSL;LLMDEDQDRIYVG;SEPMFVDA;VIPDGTDP 4 6.4 1.0033 -2.1018 7.73003 9.68848 0 0 0 0 0 7.35738 0 0 4.37657 0 0 0 0 A0A8C0T808 A0A8C0T808_CANLF Semaphorin 4G Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] CLQIIPGEGAP;DIRLLYVLA;EELSRTRHFKGQAQNYSTLLLEESS;HPLMARPVV;PQSVENLV;PYCGWDSSTHACTV;TADGWIHKAV;YNSSQDLPSLVLDF 8 11.9 1.003 -2.4203 0 7.77985 0 3.62246 0 0 10.2273 0 9.09075 0 0 11.4462 10.3642 9.22193 0 A0A8C0T809 A0A8C0T809_CANLF Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) HGF Canis lupus familiaris (Dog) (Canis familiaris) hepatocyte growth factor receptor signaling pathway [GO:0048012]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein phosphorylation [GO:0001934]; proteolysis [GO:0006508] extracellular space [GO:0005615] growth factor activity [GO:0008083]; serine-type endopeptidase activity [GO:0004252] DIPQCSEVECMTCNGE;DVPMETTE;GVPCQRWDSQYPHQHD;LHLLLLPV;SSGQDCYRGNGK;WVTKLLPLLVLQQLLLHLLL 6 11.4 1.0008 -0.63469 0 8.57913 0 0 7.42156 0 0 0 0 0 0 9.93914 0 0 7.40727 A0A8C0T824 A0A8C0T824_CANLF Family with sequence similarity 133 member B FAM133B Canis lupus familiaris (Dog) (Canis familiaris) SKKKKKKA;VIEKTKKKKKHKKHSKKKKKKA 2 8.9 0.97319 0.046699 0 0 0 0 0 0 0 0 0 0 4.47761 0 0 0 0 A0A8C0T876 A0A8C0T876_CANLF Tigger transposable element derived 3 TIGD3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AGAGITVLDALHMA;DGGAPSLP 2 4.7 1.0016 -1.252 0 0 0 0 0 10.1584 0 0 0 0 0 0 0 8.13016 0 A0A8C0T8C0 A0A8C0T8C0_CANLF WASP actin nucleation promoting factor Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleus [GO:0005634] actin binding [GO:0003779] GPKAGAKP;HSTFLFFFFYL;SSRYRGLPALGPGP;SYFIRLYGLQDCQAGLNF 4 9.2 0.86126 0.14494 0 0 7.8249 0 0 0 0 0 0 0 0 0 5.17652 5.61212 0 A0A8C0T8C7 A0A8C0T8C7_CANLF RanBP2-type domain-containing protein NUP153 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AIKCVACETPKPGTGV;GAVKSVFS;QSSPAFTMGSNGKNM 3 2.9 0.99721 -0.59278 0 0 0 0 6.86567 7.37738 10.9218 8.94682 0 0 0 0 0 0 0 A0A8C0T8C8 A0A8C0T8C8_CANLF Folate hydrolase 1B FOLH1B Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] plasma membrane [GO:0005886] dipeptidase activity [GO:0016805]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] EHVAHSHCSVQWAAEE;FGLDSVELAH;FQLAKQIQ;GVAQRDISGE;GVKSYPDGWNLPGGGV;NPLREGDSTFAAWR;VQKPQPVNP 7 7.3 1.004 -1.0394 8.07044 0 0 0 9.08148 0 0 10.0709 0 0 0 0 11.5202 0 0 A0A8C0T8F0 A0A8C0T8F0_CANLF folate gamma-glutamyl hydrolase (EC 3.4.19.9) Canis lupus familiaris (Dog) (Canis familiaris) glutamine metabolic process [GO:0006541] extracellular region [GO:0005576] gamma-glutamyl-peptidase activity [GO:0034722] AVKAAFYLAEF;NTDGKTEFISTME;PEPTRTFPACSAPAA;QSFDDGDYFPV 4 8.8 0.99231 -0.035468 0 2.6418 7.1531 0 0 0 0 0 3.25086 10.1408 0 0 0 0 0 A0A8C0T8G1 A0A8C0T8G1_CANLF Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) SLC39A4 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; recycling endosome membrane [GO:0055038] metal ion transmembrane transporter activity [GO:0046873] LTCATCRAASHYV 1 2 0.93782 0.089377 0 0 0 0 0 0 0 0 12.8069 0 0 0 0 0 0 A0A8C0T8I0 A0A8C0T8I0_CANLF Dedicator of cytokinesis 5 DOCK5 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DQEKIELLKRLIAL;EFNFSGNGN;EVKQISTEEISPL;GVAIYNYNASQ;GVAVMDITDII;ILLEKLLLEHCR;IMMEMSDNET;KILLEKLLLEHCRKHKYL;KLTEQLKPLHDRL;SVYDEEGKLLEKA;YYVYTQQELKEK 11 7.2 1.0022 -1.3621 0 0 0 0 8.962 0 11.6229 0 7.01536 0 9.37058 8.22665 9.59803 10.6891 10.8757 A0A8C0T8J6 A0A8C0T8J6_CANLF Calcium binding and coiled-coil domain 1 CALCOCO1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] AELREQYKGLSRSHGE;ASLLTRWSAPELL;RRPICCFLSWAVPSM;VRPRGGLGSVPL 4 6.6 1.0022 -0.7411 9.98812 0 0 0 6.42893 0 9.73134 0 0 0 11.4862 0 0 0 0 A0A8C0T8K5 A0A8C0T8K5_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) HPLHGPLPPPWPH;SLGPSGSP 2 2 0.9899 -0.26337 0 0 0 0 0 0 0 0 0 0 0 0 0 9.88891 0 A0A8C0T8K8 A0A8C0T8K8_CANLF PBX homeobox 4 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] CPSTPSSGSSDPFPL;QINKILKKKKK 2 5.9 0.939 0.08938 0 0 0 0 3.77284 0 7.28327 0 0 0 0 0 0 0 0 A0A8C0T8L8 A0A8C0T8L8_CANLF Endothelin-3 (Preproendothelin-3) EDN3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of vasoconstriction [GO:0019229]; vein smooth muscle contraction [GO:0014826] extracellular space [GO:0005615] endothelin B receptor binding [GO:0031708]; hormone activity [GO:0005179] EQASKGGPVHGRARRCTCFTYKDK;TPPTARSEGDIQ;VTSAAGLV 3 25.1 1.0039 -1.1044 0 0 0 0 0 0 7.60177 0 0 0 0 0 0 0 0 A0A8C0T8M5 A0A8C0T8M5_CANLF PPM-type phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] AANSPVEDRRGIASCLQ;LLGVLMPCRAFGDV;SLMSQQTLEQ;VIMDNRLLGVLMPC 4 9.1 0.98682 -0.32981 0 0 0 0 15.3682 0 0 0 0 0 8.9424 0 0 9.64972 0 A0A8C0T8N3 A0A8C0T8N3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PWPAGAAQ 1 3.1 0.99009 -0.26592 0 0 0 0 0 0 0 0 0 0 12.4157 0 0 0 0 A0A8C0T8N4 A0A8C0T8N4_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IDRWNRIEN;KILNKILAKRIQQYIKKIIHHDQVG;MDAFLESHKL;MNEKGEITTNT;NEDTTIQNLWDEAKAV;WNRIENPEVDPQLYGQL 7 10.5 0.98841 -0.47379 0 0 0 0 0 11.7977 0 0 0 0 3.74104 0 0 0 0 A0A8C0T8Q1 A0A8C0T8Q1_CANLF Sperm tail PG-rich repeat containing 2 Canis lupus familiaris (Dog) (Canis familiaris) FYNILNNTIIDKVSNT;ISDELPDLTN;PRFYEVIILQE;SVNDASPAFL 4 10.2 0.99462 -0.56064 0 0 9.29211 0 9.05015 8.83608 0 0 0 0 10.266 0 0 0 9.92563 A0A8C0T8S8 A0A8C0T8S8_CANLF Rab-GAP TBC domain-containing protein EVI5L Canis lupus familiaris (Dog) (Canis familiaris) DQIEELKAE;EELKAEGHLGCEW;GEAVASARELKL;RRRKEKLLKELIRKGIPHHFRAIV;TENRLLKQ;YPEHEFFKGQD 6 9.5 1.0031 -0.88179 0 10.606 0 0 0 0 0 0 0 10.4222 0 0 0 0 0 A0A8C0T8T0 A0A8C0T8T0_CANLF NLR family member X1 NHERF4 Canis lupus familiaris (Dog) (Canis familiaris) ALSQLFDPDACGRR;GIVAKLLPLRALPLLLNLLK;GIVAKLLPLRALPLLLNLLKVV;IVAKLLPLRALPLLLNLLKV;KLLPLRALPLLLNLLK;LGIVAKLLPLRALPLLL;LGVNNHVVECEDYAVVITVLSGW;PLMAAAGS;QLDRNQQLQELNV;SLVLGIVAKLLPLRALPLLL;VGRYGEIC;VLDWCYGRLPAFELLIP;VLGIVAKLLPLRALPLLLNLLK 13 10.5 1.0043 -1.0875 12.0936 8.48514 0 0 11.5384 7.37955 8.80122 0 0 6.42988 4.5912 11.3643 0 13.1186 0 A0A8C0T8T7 A0A8C0T8T7_CANLF Transforming growth factor beta regulator 1 TBRG1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634] GAAVRLGNVLKKLPKK;LAHEPLADTHLQH;LSQCSPTQSS;MQPQFEIVPEDDP;VLKKTSKKKK;VWRPGDGLPPQGLPEDDPTI 6 16.1 1.0031 -1.0289 0 0 0 0 0 10.5914 4.23212 9.69881 0 0 0 0 7.21189 8.31927 7.42148 A0A8C0T8U4 A0A8C0T8U4_CANLF Coatomer subunit beta (Beta-coat protein) COPB1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] IVEKMLEVFHAI;KLSQKKESEKRNVTVQPDD;LEHRHSYVRR;NNVSEHEDTDK;TKKEEERPPLRGFLLD 5 7.2 0.98947 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.69363 A0A8C0T8U6 A0A8C0T8U6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TLTPRPSLIFLLLVSL 1 13.2 0.96177 0.049233 0 0 0 0 0 0 0 0 7.15694 0 0 0 0 0 0 A0A8C0T8X9 A0A8C0T8X9_CANLF Cyclin dependent kinase inhibitor 1A CDKN1A Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346]; signal transduction by p53 class mediator [GO:0072331] nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861] DGCGEGHC 1 2.2 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 0 4.85813 0 0 0 0 A0A8C0T908 A0A8C0T908_CANLF Uncharacterized protein PRRG4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPAKEFRVFKKSMSL;LSVEDTGLPSYEQ;NRQQYPSSSATYVRRHTPSII;TVTRLCLPCWFCSANC 4 19.2 0.98807 -0.3195 0 7.57198 0 0 0 0 10.132 0 10.6993 0 2.81944 0 0 3.10412 0 A0A8C0T910 A0A8C0T910_CANLF Zinc finger C4H2-type containing ZC4H2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PIDPSCPVLFVVNK 1 4.9 0.94145 0.061072 0 0 8.79542 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T914 A0A8C0T914_CANLF NLR family member X1 NHERF4 Canis lupus familiaris (Dog) (Canis familiaris) ALSQLFDPDACGRR;GIVAKLLPLRALPLLLNLLK;GIVAKLLPLRALPLLLNLLKVV;IVAKLLPLRALPLLLNLLKV;KLLPLRALPLLLNLLK;LGIVAKLLPLRALPLLL;LPLLRKPARP;PLMAAAGS;QLDRNQQLQELNV;SLVLGIVAKLLPLRALPLLL;VGRYGEIC;VLDWCYGRLPAFELLIP;VLGIVAKLLPLRALPLLLNLLK 13 7.1 0.99942 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 4.59682 0 A0A8C0T916 A0A8C0T916_CANLF F-actin monooxygenase (EC 1.14.13.225) Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042]; exocytosis [GO:0006887] cytoskeleton [GO:0005856] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] DEEEEEEEEEEYEEEEEEEESSEVP;DEQNVEKNNQ;GEAGMGKKDDPKL;QLSFSEDSDLSSDD 4 3.1 0.97862 0.035538 4.64166 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T919 A0A8C0T919_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" EEDEDEDLEEEEEEEEEDDDQKPKR;RRMKANARERNRM;RSSPHARGAASG;SEILRSGKSPDLVS 4 13.3 0.99705 -0.090753 0 0 0 0 7.72629 7.61817 9.00203 0 0 0 0 0 0 0 10.5341 A0A8C0T924 A0A8C0T924_CANLF NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) NAXE AIBP APOA1BP Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; mitochondrion [GO:0005739] metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; nucleotide binding [GO:0000166] DEELFNEYQFSV;EAQAVDEELFNEY;EARRPHSG 3 8.7 1.003 -0.78494 0 0 14.2583 0 13.2732 8.60474 0 0 0 0 0 0 14.291 0 0 A0A8C0T932 A0A8C0T932_CANLF Pseudouridine synthase I TruA alpha/beta domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA pseudouridine synthesis [GO:0031119] intracellular membrane-bounded organelle [GO:0043231] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] EDDLVSALVQSGCIPEN;RTYFYMLPTFAFAHK;WSGFPAHCAAKG 3 11.3 0.99564 -0.11593 0 0 0 9.02234 0 6.45423 0 11.8757 0 0 0 0 0 0 0 A0A8C0T986 A0A8C0T986_CANLF MARVEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RYMPFILWPISDLLNDLFAFI 1 10 0.97764 0.047759 0 0 0 0 0 0 8.89815 0 0 0 0 0 0 0 0 A0A8C0T991 A0A8C0T991_CANLF Peptidase metallopeptidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DINGIQSIYGSLPTA;KDDNFWMIRGYAVL;NRNRLRQKRERN;RHVWRIYYDITDVEFELISSFWPSL;YRIVNYTPDMARVDVDKAIQ 5 15.9 0.99139 -0.27255 0 0 0 0 0 0 8.97616 0 0 0 0 0 0 0 9.28543 A0A8C0T9A1 A0A8C0T9A1_CANLF DUF4485 domain-containing protein CEP112 Canis lupus familiaris (Dog) (Canis familiaris) AEFDHFVVDMK;ENKFQMEKSHLKRTYEKKIHDLQ;LLQTKYDAD;VGRKNRNLYAKLLLHML;VLKLSHRSERQRCALWIRKLC 5 8.9 0.99416 -0.073574 0 3.35262 0 4.38722 0 0 0 0 8.37077 0 0 0 9.41785 8.28748 0 A0A8C0T9A4 A0A8C0T9A4_CANLF BCLAF1 and THRAP3 family member 3 BCLAF3 Canis lupus familiaris (Dog) (Canis familiaris) EDRKSSSQKG;IERRRKERL;KFRQKLLRKKKEYANIAT;PQRSAADSFRFEGKWHEDKLRH;QKRYPEDRAF 5 10.1 1.002 -0.9598 0 0 0 0 0 0 0 0 0 4.68021 12.631 0 0 10.9906 9.91947 A0A8C0T9A7 A0A8C0T9A7_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ELNGRRGVFPDNFVK;ILYRAAPGKTEGHR;NFIKELSGESDDLGI;PPSAPVIKQGAGTT;THGLPSPG;VGWWEGELNGR;WWEGQINGRRGLFPDNFVREIK 7 9.1 1.0039 -1.6821 0 11.7697 7.62965 8.46675 0 0 9.67888 10.7349 10.2082 5.97104 0 7.48615 0 10.1968 0 A0A8C0T9D2 A0A8C0T9D2_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] APGVGRFVTSMAA;ELPLFFSFPPPGDAWEL;ELTLGAYGRTVVPFAVPGASRLDQ;LDTPLVIKELSKVY;LHPPPPHCVAGPRS;PHCDPEAV;QLKGLSHHKCPE;TVLLGHNGAGKTTTLSM;YHLRFSYTRRNYMWTQTGSFFLKE 9 7.9 1.002 -0.90464 0 0 6.4191 0 0 0 11.5624 8.38219 12.9681 0 7.46565 9.81873 0 0 10.1371 A0A8C0T9D9 A0A8C0T9D9_CANLF Polyhomeotic homolog 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AIHHQQQFQHRQSQLLHT;FVIQEGAEPFP;GLPTGLNENQSGGPL;LASGMSLA 4 5.6 1.0008 -0.63165 0 0 0 0 0 0 11.0404 0 0 10.1239 0 0 0 0 9.231 A0A8C0T9E4 A0A8C0T9E4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046] QVTNDVGSDSCTT;VENDFGSSSYQDIP;YRLVCHENTV 3 6.5 0.99425 -0.55953 8.12738 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T9E6 A0A8C0T9E6_CANLF Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) CDK8 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ADKDWEDIKKMPEHSTLMKDFRRNT;HYTKAIDIWAIGCIFAELLTS;LDGIHYLHANWVL 3 13.9 0.97575 0.035538 0 0 0 0 0 0 7.77571 0 0 0 0 0 0 0 0 A0A8C0T9E8 A0A8C0T9E8_CANLF Protein kinase domain-containing protein ULK4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LDVDNKNNNETAAALLF 1 1.5 0.97726 0.046227 0 0 0 0 0 0 0 9.2723 0 0 0 0 0 0 0 A0A8C0T9G9 A0A8C0T9G9_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ELDNSWGS;NEEPLFPWTRATVSV;TLELEEEDQGP;VIHGHIFPFMEPAP 4 7 0.99034 -0.19631 0 0 0 0 0 0 0 0 0 0 0 0 7.5601 0 0 A0A8C0T9H2 A0A8C0T9H2_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hexose transmembrane transporter activity [GO:0015149] EADFLKQNQG;EADFLKQNQGPNWSGP;LVNNIFVVAAATLFGFSR;VSMSVQPMYLGESAP 4 9.8 0.98786 -0.46 6.34403 0 0 0 0 0 0 0 0 0 6.35644 9.02666 0 0 7.30779 A0A8C0T9H3 A0A8C0T9H3_CANLF Vasopressin V1a receptor AVPR1A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] vasopressin receptor activity [GO:0005000] VLPQMCWDITYRFRG;YVTWMTAGIFV 2 6.3 0.93595 0.098158 0 8.98905 0 0 0 0 0 0 0 0 0 0 0 10.8911 0 A0A8C0T9I3 A0A8C0T9I3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CSNK2A1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ESHVVEWGNQ;KVVVKILKVSIRNHFRGI 2 32.6 0.97536 0.048313 5.82927 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T9J7 A0A8C0T9J7_CANLF Ras association domain family member 5 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] nucleus [GO:0005634] EMEEEVSG;LKENETGEVEW 2 4.4 0.98797 -0.34286 0 0 9.28912 0 0 0 0 9.86385 0 0 0 9.97757 9.09017 0 9.70235 A0A8C0T9L0 A0A8C0T9L0_CANLF Terpene cyclase/mutase family member (EC 5.4.99.-) LSS Canis lupus familiaris (Dog) (Canis familiaris) triterpenoid biosynthetic process [GO:0016104] lipid droplet [GO:0005811] intramolecular transferase activity [GO:0016866] AGIDWPAHRSSVAPDEL;DTARAAALNGITFYVGLQA;TSAVMQALKLFHQC;TSFAVQAL;VSLRILGVGP 5 9.8 1.0017 -0.75278 11.2302 10.6695 10.5065 9.7137 0 9.9928 11.2952 0 0 0 10.823 10.7276 0 10.5677 10.664 A0A8C0T9L6 A0A8C0T9L6_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LSPTLLHHAMDHSI 1 4.9 0.94922 0.081534 0 0 0 0 0 0 0 7.05202 0 0 0 0 0 0 0 A0A8C0T9M1 A0A8C0T9M1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;INLTKDVKDLHPQNYRTLL;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.9 0.94283 0.061114 0 0 0 0 0 0 12.359 0 0 0 0 0 0 0 0 A0A8C0T9M7 A0A8C0T9M7_CANLF Bromodomain adjacent to zinc finger domain 2B BAZ2B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CIQIKEEIFETS;DDDDDDDSD;DDDDDDDSDDQADEDDEDEE;DEDDESDDSQSE;DEEDDEDDESDDSQSESD;DEEEDEEDDEDDESDDSQ;DFDDDDDDDSDDQ;DFDDDDDDDSDDQADEDDED;DQSIEESEDDD;DSDFDDDDDDDSDDQ;EDDEEEDEEDDEDDES;EDDEEEDEEDDEDDESDDS;EDSNEDEEEDDEEEDEEDDE;EEDDEDDESDDSQS;EEDDEEEDEEDDEDDESDDSQ;EEDEEDDEDDESDDSQ;EEDEEEEDQSIEESEDDDS;EESEDDDSDS;ESEDDDSDSESEA;ETSEDTLNCSNPDHCEQKEDPK;FDDDDDDDSDD;FDDDDDDDSDDQ;GGDSDFDDDDDDDSDD;GLHSASSGHSEFGGLGTLGTPTA;LKALLKVLHLRGIREKALQ;NEDEEEDDEEEDEEDDE;NSESDTEGSEEDDDDD;SDFDDDDDDDSDDQAD;SEDSNEDEEEDDEEEDEEDDEDDES;SEDTLNCSN 30 8.3 0.98773 -0.48799 9.78802 10.3196 6.88289 0 6.62319 9.74999 9.62339 9.31352 6.26166 5.45638 5.15725 8.17852 5.83347 7.43313 6.90689 A0A8C0T9P9 A0A8C0T9P9_CANLF Palmitoyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] palmitoyltransferase activity [GO:0016409] AFIFVMTM;WINNCCGYQ;WKPENSQDSMYLQYCK 3 8.6 1.0024 -1.8594 0 6.3535 0 0 8.04887 0 0 0 0 9.69577 0 0 0 0 0 A0A8C0T9R6 A0A8C0T9R6_CANLF Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DLEHMPSG;RLAALEVAS;YEALFGQPPFASRSFTELEEKI 3 8.3 0.99006 -0.26657 0 0 0 0 0 0 0 0 9.19975 0 0 0 0 0 0 A0A8C0T9S2 A0A8C0T9S2_CANLF Peptidase metallopeptidase domain-containing protein MMP17 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LAGCGACSRRQSGAEPC;PQARCWQPHCYCPRAPCG;QQHTQPCRGH 3 6.7 0.98763 -0.48541 0 0 0 0 0 0 8.13273 0 0 0 9.23723 0 0 0 0 A0A8C0T9S9 A0A8C0T9S9_CANLF MYB proto-oncogene like 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] EHTASVKKVRKS;FTTSLLMIPL;LAVEANAVLSSL;VEQIQSSSFI;VPQQKGLKK 5 7.1 1.0034 -1.3811 0 10.7683 0 0 0 0 0 0 0 0 0 0 10.4118 0 10.676 A0A8C0T9U6 A0A8C0T9U6_CANLF Chemokine like factor CKLF Canis lupus familiaris (Dog) (Canis familiaris) GVLMYRKLLFNPSGP 1 22.4 0.94975 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.96157 A0A8C0T9X5 A0A8C0T9X5_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] GGGGGGGA;GGGGGGGG;SASLETMVPPA 3 9 0.98553 -0.25941 0 0 7.78829 5.93511 0 0 0 0 0 0 0 0 0 0 0 A0A8C0T9Y0 A0A8C0T9Y0_CANLF tRNA (32-2'-O)-methyltransferase regulator THADA Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] cytosol [GO:0005829] DSESASRLQTILNEIQ;ELAYTGFV;ENTCRSTEFAFCQVDA;EVKGKERKTCD;LAVLCDLLQQW;RPVIEKLLLMSYR;STSSRRPLSP;VYTHWEHPLDALRHQT 8 5.4 1.0024 -1.8707 0 13.3008 7.656 0 0 12.455 0 13.7602 12.7928 0 0 13.18 0 0 0 A0A8C0T9Z3 A0A8C0T9Z3_CANLF Vacuolar protein sorting 13 homolog C VPS13C Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid droplet [GO:0005811] AYYEIRYQFYKRDQLMWSV;DSYRCQLFIQPAGILENHYKVSTTY;EALLSFMDFL;ESESDDEYFDAEDGDT;FFALTFVPHGYT;FRFQMTLYPDA;FVFPPSVHGNMLKIP;GVESESDDEYFDAEDG;ISLDYHEI;KKSTDTGEKRGGWFSGF;NLGEASSQPSPTQTIQE;SCLNVFNNLAKG;VGCIQIVYLHKFLMSLLNFL;VGGAAGVV;VGKGLAAI;YDAEKEEKSLQDIKQ 16 5.7 1.0009 -2.7267 17.4732 0 10.4034 9.37803 0 9.71831 0 17.7229 0 9.23654 17.724 12.2602 9.58226 0 13.3204 A0A8C0T9Z5 A0A8C0T9Z5_CANLF glutathione transferase (EC 2.5.1.18) LOC486404 Canis lupus familiaris (Dog) (Canis familiaris) KMFITGDHISLADLVALVEMMQAGE 1 9.7 0.97998 0.035538 0 0 0 0 0 0 0 0 8.98319 0 0 0 0 0 0 A0A8C0T9Z7 A0A8C0T9Z7_CANLF Uridylate-specific endoribonuclease (EC 4.6.1.-) Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] metal ion binding [GO:0046872]; polysaccharide binding [GO:0030247]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; scavenger receptor activity [GO:0005044] AACQCDRRCHRHGDCCEDYEH;CQCDRRCHRHGDCCEDYEHLCSEDP;ELDGFLRQQNRYS;RHGDCCEDYEH 4 9.7 0.99432 -0.11802 0 0 10.749 0 5.26322 5.71342 0 0 0 0 0 0 0 0 5.61806 A0A8C0TA03 A0A8C0TA03_CANLF T-complex protein 1 subunit gamma CCT3 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] DVTHPRMRRYI;TVVISAYRKALDD;VLSEVERN 3 6.4 0.98603 -0.41473 9.0247 0 0 0 0 8.17338 0 0 10.5777 0 0 0 0 0 0 A0A8C0TA17 A0A8C0TA17_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TRIO Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] cytoplasm [GO:0005737]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine/threonine kinase activity [GO:0004674] AGHGGGKG;AIQQHSLLQPD;AYVLLSGVSP;DLDLEGQKLLQRIQS;EEIYQAAHQLEDRIQDFVRRVEQ;ESPRRCSG;FNPSDNSL;GATSPLNSP;GGGGGGSG;HQIYDWHRDFFLGELEKCL;HYWTMRKRRLDQCQQYVVFERS;LKLLLLGQR;PENILVDQSLAKPTIKLADFG;PLQKGGSFWSSIPA;SEQVCSVLESLEQEYK;SFIERRKHQND;SLRMEKYRTSLEKA;TFILHSSSPSVRQ;TPTSYVLV;VGKSLHRA;VGKSLHRARAL;VIHDFTAC;VLEMADQGRLLDC;VRLHQRLQLCVF 24 9.3 0.99688 -7.5086 12.5652 0 11.0649 8.72072 7.74947 5.10786 12.1573 12.8205 11.2147 0 8.52998 10.78 4.19621 10.8139 8.9824 A0A8C0TA46 A0A8C0TA46_CANLF Phosphatase and actin regulator PHACTR3 Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779]; protein phosphatase inhibitor activity [GO:0004864] LRDTALGDIFGL 1 2 0.95333 0.05044 0 8.04346 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TA47 A0A8C0TA47_CANLF 78 kDa glucose-regulated protein (Binding-immunoglobulin protein) (Heat shock protein 70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) HSPA5 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968] endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] DLGTTYSCVGVFKNGRVEI;ETLTRAKFEELNMDL 2 5.7 0.99236 -0.17826 0 0 0 0 0 0 0 0 0 0 0 7.27408 10.829 0 0 A0A8C0TA54 A0A8C0TA54_CANLF Plexin cytoplasmic RasGAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor activity [GO:0017154] IKKKKKKKLIT;LLYIKKKKKKKLITRQ;LYIKKKKKKKLITRQ;QLLYIKKKKKKKLIT;QLLYIKKKKKKKLITRQL;TQLLYIKKKKKKKLITR;YAKRYRTQLLYIKKKKKKKLI 7 41.7 0.64286 0.33418 0 5.10706 0 0 0 4.89995 0 0 7.21965 0 4.12549 12.2898 0 8.72802 0 A0A8C0TA56 A0A8C0TA56_CANLF "WD repeat, SAM and U-box domain-containing protein 1" WDSUB1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] MCDAFLSF;PVIASGMCDAFL 2 3.2 0.98954 -0.21548 0 0 0 0 14.8727 0 0 0 0 0 9.30863 0 0 0 0 A0A8C0TA67 A0A8C0TA67_CANLF Family with sequence similarity 216 member A FAM216A Canis lupus familiaris (Dog) (Canis familiaris) HAALPRTQPQWPGPR;STNDSESYMNEE 2 8 0.95536 0.053879 0 0 0 0 3.96689 0 0 0 0 0 0 0 0 0 0 A0A8C0TA90 A0A8C0TA90_CANLF Microtubule actin crosslinking factor 1 MACF1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104]; wound healing [GO:0042060] cell projection [GO:0042995]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; membrane [GO:0016020]; microtubule [GO:0005874] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198] CTSMPSSP;EEIESHATDVHQAVK;ESGQPVQCESDVI;GADLIFAC;GHNLTPEERQVLQDKLGE;GVWELIRAVLSQCLLCVS;IETLTARDEHQAGPPEMFEVGHQRL;IVKDYELQLMTYKA;LAASGGQSPTGEQIPQFQQRQK;LKETSSFR;LSQSEAKNP;LVDNLRSVCIPDVM;LVDWLYKVE;MTTAAEEGEA;MVRVGGGWMALDEFLVKNDPCR;PHMQLADSSERS;PLSIDPNMLT;PSEMLQEATL;PSEQKPMNTSEKS;QKFLQDHQEFENWLERSERELENM;QQHEQLNEAAQGILTGPGD;SFMGLLWPESGEILPITDGL;SIDIIRHKDS;SLEEMTQRLKEFQESFKNI;TLEQARQLATKFQSTY;VDKAGVWELIRAVL;VKDYELQLMTYKAFVE;WETYEELSPWI 28 5.1 0.91595 0.1091 0 0 0 0 0 0 0 0 0 0 8.13484 0 0 0 7.86938 A0A8C0TAA7 A0A8C0TAA7_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST3A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sulfotransferase activity [GO:0008146] ESLTFKNRSTGLIDTSWSA;GGGGGGGA;GGGGGGGG;GGGGGGGGAGAPGRGALAGGPG;LCSLLTSLYVFYCLAE;LRHFPLGQMLFVSGERLISDPAGE;YRDLMPRTLDGQITMEK 7 24.3 0.98937 -0.31256 0 11.3735 0 0 8.15228 0 9.94755 0 0 0 0 0 9.92457 8.65442 8.94462 A0A8C0TAA9 A0A8C0TAA9_CANLF "N-alpha-acetyltransferase 16, NatA auxiliary subunit" NAA16 Canis lupus familiaris (Dog) (Canis familiaris) NatA complex [GO:0031415] KKCHEVERHSPS;KWMDEAQSLDTADRF;LEHIETYEKQ;LIDRNAENWCYYEGLEKALQLSS 4 11.1 0.94466 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.8703 0 A0A8C0TAB4 A0A8C0TAB4_CANLF Myeloid leukemia factor 1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EPLAPRPAPPRPQRP;NNKTGDEEVNQE;VGVAAAAA;VPFGSFGG 4 12.5 1.0031 -1.5507 5.73666 17.6266 17.4261 0 0 0 3.6193 17.7695 17.6538 9.54531 11.7677 11.7423 3.70786 10.1464 0 A0A8C0TAD1 A0A8C0TAD1_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101]; metal ion binding [GO:0046872]; protein kinase B binding [GO:0043422]" AGLLPGQWIEAEEDEDTESCYDEDG;CYDEDGEELDSDDE;DEDTESCYDEDGEELDSDDEEI;DTESCYDEDGEE;EAEEDEDTESCYDE;EAQNEPQPNIEQ;EARNMVSDLL;EDTESCYDEDGEELDSDDEEIE;EEDEDTESCYDEDG;EEIEDNLNPKPQ;GFLFHLCRLCNV;PGPGAGAG;TPAGRSGGCKMFR;VLENHHAASAWNLYL 14 9.4 1.0029 -1.7237 7.86059 7.05561 0 0 0 0 9.65953 4.40905 0 0 9.29586 0 8.38741 0 0 A0A8C0TAF3 A0A8C0TAF3_CANLF N-acetylated alpha-linked acidic dipeptidase like 1 NAALADL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carboxypeptidase activity [GO:0004180] AGVLVYTD;FEDAKILLCNLQGASA;GALDQRISAL;KGTNSQHLQDLDLEILESIMQ;LQDLDLEILESI;PDTVSGFPPIPTQPIGFEDAK 6 10.2 0.98762 -0.46053 0 0 0 0 0 0 0 0 9.80391 0 8.77297 0 9.55607 8.47925 10.1506 A0A8C0TAG2 A0A8C0TAG2_CANLF "N-alpha-acetyltransferase 16, NatA auxiliary subunit" NAA16 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HNATSLQHL;KWMDEAQSLDTADRF;LEHIETYEKQ;LIDRNAENWCYYEGLEKALQLSS 4 7 1.0027 -0.77768 0 0 0 0 0 0 11.7705 0 0 9.76173 0 0 11.5255 0 0 A0A8C0TAI8 A0A8C0TAI8_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein FABP12 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] GPKAGAKP;LVDGKMVVESAVNNV 2 14.5 0.94864 0.053909 0 0 0 0 0 0 0 10.394 0 0 0 0 0 0 0 A0A8C0TAJ4 A0A8C0TAJ4_CANLF C2H2 AKAP95-type domain-containing protein AKAP8L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CSDNSDSDNDE;YDYGELDPEMEMAYEGQYDAYRDQF 2 5.5 0.9386 0.071029 0 0 7.42063 7.01892 0 7.69912 0 0 7.71232 0 7.62491 6.74725 0 0 8.04078 A0A8C0TAJ7 A0A8C0TAJ7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;SLELKRFMET 4 4 0.9984 -0.61146 0 8.91979 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TAJ9 A0A8C0TAJ9_CANLF UBC core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAAEHHLRDKEDFRNKVEDYIKRY;LRKKKKKT;RLRAPPTRVRRLRKKKKKTTRGDPA 3 16.8 1.0025 -0.76886 0 0 0 0 0 0 0 0 0 0 6.25558 0 0 0 10.3919 A0A8C0TAL2 A0A8C0TAL2_CANLF Family with sequence similarity 92 member A Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriole [GO:0005814]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634] EEDLEAFRNSLY;GGGWGAGG;KDQQAEDDDEEDE;RGARVVGP;VGARCRTQSRPE 5 8.5 1.0021 -1.8816 0 0 0 0 5.99826 0 0 0 0 13.248 6.97418 0 9.94778 0 0 A0A8C0TAN1 A0A8C0TAN1_CANLF Zinc finger CCCH-type containing 12B ZC3H12B Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] ILRKLEKEKILVFTPSRRVQGRRVV;SASKEEKQQSKQDSMEQSN;SPELSLEDEIDNSE;VTNSHGTPISYADQYPKF 4 9.1 0.86082 0.16289 0 0 9.451 0 0 0 0 8.32278 0 0 0 0 0 0 0 A0A8C0TAP1 A0A8C0TAP1_CANLF TNFR-Cys domain-containing protein TNFRSF1A Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; prostaglandin metabolic process [GO:0006693] plasma membrane [GO:0005886] tumor necrosis factor receptor activity [GO:0005031] GTATPRTEGEL;LPTVPGLLLPLVLLALLLE 2 5.4 0.98956 -0.1978 0 0 8.69971 0 0 0 3.616 0 0 0 0 0 0 0 0 A0A8C0TAP3 A0A8C0TAP3_CANLF Chitinase domain-containing protein 1 CHID1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] endomembrane system [GO:0012505] chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492] MTYDYPTAQQPGPNAPLSW;VGGGGGCQ 2 3.7 1.0031 -1.1044 0 7.11468 9.13773 0 0 0 0 0 9.24551 0 0 0 0 0 0 A0A8C0TAP6 A0A8C0TAP6_CANLF Coagulation factor VIII F8 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] AAATEKTGSLGPPNMSVHF;EDPTLKENFRFHAINGY;HVLSRAVSTPLPHGGQR;KTREAIQYESGILGPL;KYKWTVTVE;LSVFFSGYTFKHKMV;MPLGMESKAISDAQITA;NEDKDYDDGLYDSDMDVVS;NQMVERFP;RTSGVQEGSHFLQ;SDVDLEKDVHSGL;SLTQAEAQ 12 7.3 1.0036 -1.6523 8.32809 10.9004 0 8.75862 0 7.66235 9.84248 10.7681 0 0 0 3.30781 11.3113 9.84516 8.79266 A0A8C0TAR6 A0A8C0TAR6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GAGPRAGWAG;GGRGGGGG 2 3.4 0.99957 -0.61146 0 0 0 7.90809 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TAS6 A0A8C0TAS6_CANLF Exocyst complex component EXOC6 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145]; membrane [GO:0016020] ADYDWTMSEPD;DEFVQLADYDW;DSELKQISMGAVQ;EEEYKAVISKFPFQDP;EKLDACIRNH;ELKQGFEEEDENEEEIL;ESIRKHSDKIGETAMKQAQ;STDTACVGPTLRSVYDDQP;VISKFPFQDPDFEKQ 9 15.9 0.97687 0.046227 0 0 0 0 0 0 4.67593 0 0 0 0 0 0 0 0 A0A8C0TAW9 A0A8C0TAW9_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1" SMARCA1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; nucleosome binding [GO:0031491] AVLKPFLLRRIKTDVEKSLPP;DTEQSLYKFEGEDYR;EDYCMWRGYEYC;LHAVLKPFLLRRIK;MLHKMGFDRE;VEERIVERAE 6 6.3 0.98651 -0.39436 0 0 0 0 0 0 11.1719 0 0 5.35463 0 7.88069 0 0 0 A0A8C0TAX8 A0A8C0TAX8_CANLF P53-induced death domain protein 1 PIDD1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EAAWDDITAQ;EAEGLEPQAAATEDAAGDAT;EAWGWSGAEGRAHCTPS;GRVCFVFYSHLKNV;RLQGNPLGE;TGLSLDRSCLH 6 9.1 1.0017 -1.2487 0 0 10.842 0 0 0 0 6.71328 0 0 0 0 9.94382 4.89593 0 A0A8C0TAZ7 A0A8C0TAZ7_CANLF Myotubularin phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of autophagy [GO:0010507]; phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; membrane [GO:0016020] phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] EDEELLRAA;EDEELLRAAG;LRLGDAWHFH;LTWPSPFPAR 4 7.7 1.0039 -2.0417 0 0 0 0 0 0 10.4001 0 0 0 0 0 10.3603 0 0 A0A8C0TB01 A0A8C0TB01_CANLF Protein tweety homolog Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254] GGGGGGGE;GGGGGGGG;QDRVWDTAAALNRSAEPS;QEVLNGTEVNL;SFWLCCRRRKSEEHLDADCCCT;VLAEQADVYDWY;VTEYMSQNANFQ 7 13.1 0.99123 -0.30044 9.95385 0 0 7.14088 0 8.22949 8.03447 11.4376 0 0 0 0 0 0 0 A0A8C0TB12 A0A8C0TB12_CANLF INSC spindle orientation adaptor protein Canis lupus familiaris (Dog) (Canis familiaris) asymmetric cell division [GO:0008356] IMGMLSEKPRS;IYTTESTTGNL;LANITFFDTM;PAESPTPSCSCS;VISTELRRIGQ;VLLEACSDKQRVDTPY 6 11.3 1.0022 -1.2825 0 0 13.8739 0 0 8.57293 7.64875 0 9.57675 0 20.1254 13.9304 0 0 0 A0A8C0TB20 A0A8C0TB20_CANLF Zinc finger AN1-type containing 3 ZFAND3 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; zinc ion binding [GO:0008270] KNSPPPQR 1 3.7 0.98812 -0.26463 0 0 0 0 0 0 0 0 0 0 0 0 10.6778 0 0 A0A8C0TB32 A0A8C0TB32_CANLF Tripartite motif containing 77 LOC119864875 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] NWVLGFCDDSWTM;RGMYEDLKKMCRKPDTELLQHFE;SFVHVASS;SSSLICSFLSCSF 4 12.6 0.97668 0.046423 0 0 0 0 7.78555 0 4.09795 0 0 0 0 0 0 0 0 A0A8C0TB36 A0A8C0TB36_CANLF Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; motile cilium [GO:0031514] ligand-gated sodium channel activity [GO:0015280] CICMSQDCSSQ;CMSQDCSSQEA;LLVITFLMLLRRFRSR;QVNRKDWK;WPGQGLAG;YSRWPSVTSQDWIFQM 6 6.7 1.003 -1.5066 0 9.47046 6.52913 6.70764 6.38833 0 0 0 6.67624 6.33346 7.27174 7.08098 0 0 0 A0A8C0TB42 A0A8C0TB42_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" VPLKLCPAAEPGSP 1 4.2 0.94418 0.061128 0 0 0 0 0 0 0 0 0 0 9.48886 0 0 0 0 A0A8C0TB48 A0A8C0TB48_CANLF AKNA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CSLTMTEENTSDI;KGTCRNADITMTLGKMT;LKIKVIFLKL;LKIKVIFLKLI;NCETLPEIADADSSD 5 12.1 0.99697 -0.57597 0 0 3.92343 0 0 0 0 0 0 0 0 5.64801 0 0 0 A0A8C0TB52 A0A8C0TB52_CANLF WSC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] EAECDMGC;EAECDMGCKGERGS;VLYLTAGSLVFL 3 4.6 1.0032 -1.5924 0 0 0 4.94995 0 0 0 8.20643 0 0 0 0 0 0 0 A0A8C0TB53 A0A8C0TB53_CANLF Espin like Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] stereocilium [GO:0032420] actin binding [GO:0003779] AAATGGLAELCWLV;GVSVRTLRGHFE;LHHAAVSG;LLLMGAPVVTDSWGGTPLHD;TEDDLVYLEKQIADLQ;TGAAPGPGDAEEAS;VECCQTLVSHH 7 9.5 1.0021 -1.421 0 4.85947 7.91073 8.78352 0 0 0 0 0 8.91394 0 8.69791 0 6.89263 0 A0A8C0TB54 A0A8C0TB54_CANLF Proline dehydrogenase (EC 1.5.5.2) LOC477562 Canis lupus familiaris (Dog) (Canis familiaris) proline catabolic process [GO:0006562] proline dehydrogenase activity [GO:0004657] AAGSPEGFSGGGK;ILAKKAAE;YKYVPYGPVMDVL 3 5 0.99036 -0.26638 0 0 0 0 0 0 9.27249 0 0 0 0 0 0 0 0 A0A8C0TB69 A0A8C0TB69_CANLF Ig-like domain-containing protein CILP2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] AAPSDLRFVDSDGE;SVRDPERPGT;VILDAGESN 3 3.1 0.98728 -0.49926 0 7.93776 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TB73 A0A8C0TB73_CANLF Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) Canis lupus familiaris (Dog) (Canis familiaris) JNK cascade [GO:0007254] cytoplasm [GO:0005737] ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709] DVVPLSGQGGGGPSPSPG;LSAALGARGRGATGGAGDPGSPP;LSGQGGGG;WVGSGAQGAVFLGRFHGE 4 6.6 0.99212 -0.16612 0 0 9.02829 0 0 8.06469 8.49813 0 11.2776 0 0 0 0 0 0 A0A8C0TB83 A0A8C0TB83_CANLF Wnt inhibitory factor 1 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; extracellular region [GO:0005576] signaling receptor binding [GO:0005102] KMAPFTHDFRKAQQ;SKCPQPCRNGGKCI;TGAAPGGC 3 4.6 1.0031 -1.1044 0 0 0 0 0 0 10.1734 0 0 0 0 0 0 0 0 A0A8C0TB96 A0A8C0TB96_CANLF Olfactomedin-like domain-containing protein OLFM4 Canis lupus familiaris (Dog) (Canis familiaris) VGSTVIVD;VGWQDIDLAV 2 3.8 1.0027 -1.404 0 0 0 0 0 0 0 0 0 0 4.50061 0 0 0 0 A0A8C0TBA7 A0A8C0TBA7_CANLF "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)" GFM1 EFG1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translational elongation [GO:0070125] mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] DSNEISFIRAGEG;EVERALRQM;GHKLSGLRFVLQDGAHHMVD;TYVRNYQG 4 7 1.0041 -1.0911 9.97985 9.64095 9.15477 0 0 0 0 0 8.94392 0 0 3.29339 0 0 14.367 A0A8C0TBC2 A0A8C0TBC2_CANLF Protein phosphatase 1H (EC 3.1.3.16) PPM1H Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] protein serine/threonine phosphatase activity [GO:0004722] DHIARPILILKETRRLP;GGGGGSDLP;VSCHYWSLFDGHAGS;YFRAYLYYLFIYLFLIFYLFMRD 4 11.9 0.97808 0.046253 0 0 0 0 0 0 0 0 9.13773 0 0 0 0 0 0 A0A8C0TBD3 A0A8C0TBD3_CANLF AIG1-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] DTPDLLSPQAG 1 4 0.98947 -0.214 0 0 0 0 0 0 8.21057 0 0 0 8.92193 0 8.38638 0 0 A0A8C0TBE4 A0A8C0TBE4_CANLF Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] endoplasmic reticulum membrane [GO:0005789] lyase activity [GO:0016829] GPKAGAKP;IEPNHLLPRFLQLTERIIILFVVIT;PAWLQPRYRKSTYLFIYYLIQFC 3 13.9 0.94465 0.081811 6.51305 0 7.50827 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TBE7 A0A8C0TBE7_CANLF Uncharacterized protein C24H20orf96 Canis lupus familiaris (Dog) (Canis familiaris) IQKKKKKLLKALVV;KKKKKLLKAL;KKKKKLLKALVVK;KKKKLLKALVVKS;KKLLKALVVKSQ;LYSKPTMLMTSQL;QIQKKKKKLLKALVVKS;QKKKKKLLKALV;QKKKKKLLKALVVKSQQP;RNPQEKHRGKLDSEKAQAKIQ;VISFWRCFLNPLCCVLEVTLWSP 11 18.8 0.98747 -0.46801 12.9506 8.25781 3.9514 0 3.82741 5.19109 0 0 9.33666 0 10.6028 0 0 0 0 A0A8C0TBF3 A0A8C0TBF3_CANLF TRAF3 interacting protein 1 TRAF3IP1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] AEALQKEQSITDC;EGGKEKEKWKDRERERERDKARDRD;EGRKEDNISAKILDPIVSGL;ESDRDKHREGERE;ICAVKANVL;KEDKRNSEINERSTSR;PAVKQKEGEVGPPGPE 7 16.5 1.0021 -0.6911 0 7.94965 0 8.85658 9.44284 0 0 8.03623 0 10.0773 0 0 0 0 8.8763 A0A8C0TBH1 A0A8C0TBH1_CANLF MBD domain-containing protein MECP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] heterochromatin [GO:0000792]; nucleus [GO:0005634] chromatin binding [GO:0003682]; double-stranded methylated DNA binding [GO:0010385]; methyl-CpG binding [GO:0008327] EGSGSAPAVP;EKKEDKEGKHEPLQPP;KFKKVKKEKKE 3 19.2 0.9903 -0.50985 9.92782 0 0 0 0 5.88362 10.5899 0 0 0 0 0 0 0 0 A0A8C0TBI0 A0A8C0TBI0_CANLF Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; GDP-mannose biosynthetic process [GO:0009298] mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270] SHEALGAG;WLRRGIQCLGSGL 2 4.3 0.98928 -0.26592 0 0 0 0 0 0 0 0 5.16495 0 0 0 0 0 10.0596 A0A8C0TBI6 A0A8C0TBI6_CANLF Inositol monophosphatase 1 (EC 3.1.3.25) (EC 3.1.3.94) (D-galactose 1-phosphate phosphatase) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) Canis lupus familiaris (Dog) (Canis familiaris) inositol biosynthetic process [GO:0006021]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737] inositol monophosphate 1-phosphatase activity [GO:0008934]; zinc ion binding [GO:0008270] AYYEMGIHCWDMA;ETASKRRK;LPFVCDGCSGVFCLE;LTDSPTWIIDPI;SDKPTSYPCSF 5 11.4 0.99148 -0.2768 0 0 0 0 0 0 4.47502 0 0 0 0 0 0 0 0 A0A8C0TBI7 A0A8C0TBI7_CANLF Lymphocyte antigen 75 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] carbohydrate binding [GO:0030246] DEQKWWVRTTD;FLFQRNRLHWAGFSSVRYEQGM;HTYGGTLPSVL;LCQKYSEIENRQ;LDETYGGPWCATTLNYEYDKMWG;PWIPFQNSCYNFVIAKTKYTA;RRFMYSRYPWHHF;RSWYFYDDREFIYLRPFACDTKLE;SGLWQSFSCE;SHDGSESSFEWSDGSTFD;TKLHNGDAKEEIWIG;VLEQLLHLNNMA;VLHNSSLWIGLSSQDDGLNGWL;YREHCYAFDQALHSFSEAEQ 14 13.6 0.99095 -0.30058 4.53928 0 0 0 0 13.2483 7.62892 0 9.97255 0 8.87 8.54709 0 8.62227 10.1652 A0A8C0TBJ1 A0A8C0TBJ1_CANLF Phospholipase A2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] phospholipase A2 activity [GO:0004623] CFELIPEEEC;EDTDEKPKPKKKVKKGKLIK;KKKVKKGKLIKKK;KPKPKKKVKKGKLIKKKS;KPKPKKKVKKGKLIKKKSPV;KVIKKVKK;KVIKKVKKKKE;KVKKGKLIKKK;PKKKVKKGKLIK;PKPKKKVKKGKLIK;PKPKKKVKKGKLIKKK;PKPKKKVKKGKLIKKKSPVK;TIERWTKEKTEDNAT 13 18.1 1.0029 -1.8884 4.4161 5.2684 7.71239 3.28562 4.48046 0 8.67197 0 0 0 4.65833 3.92685 5.56297 9.26207 0 A0A8C0TBK0 A0A8C0TBK0_CANLF SUMO specific peptidase 6 SENP6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] DFSEDQDNQDDSSDD;EKENQTKCQSCGIL;GTVVHGRRFHHAN;GVYVLQYVESFFE;GVYVLQYVESFFENPILNFE;SEGEFLNDVIIDFYLKYLVLE;SSDDDDDDNDRTNR;VGTLFRLLIE 8 9.4 1.0019 -0.99285 0 0 9.54023 0 10.5939 6.59205 0 0 7.2556 0 0 0 0 10.58 0 A0A8C0TBK2 A0A8C0TBK2_CANLF G-protein coupled receptors family 3 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; regulation of synaptic transmission, glutamatergic [GO:0051966]; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553]" postsynaptic density membrane [GO:0098839] adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583] AAGGGGGG;EGICIAHSYKIYSNAG;GAGGGGGG;NPWFQEFWQHRFQC;RAGSAGRTDDDVPSLHS;TMTTFAEIQPLP;VLLLILSVLLLK;YIAFTMYTTC 8 8.1 1.003 -0.73792 13.6884 0 0 0 0 0 0 0 0 0 0 0 9.5808 4.41752 7.20526 A0A8C0TBK7 A0A8C0TBK7_CANLF Kinesin-like protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DTELEEGATVIAHKVGDQMVVLMDP;LEMRRSLVELENTNIELHV;LETDSGYRSSQGTPSK;QEDVYRATTQHLVEGVVSGYN;TAAEHGAESQPSPAVL;TDCSVSMSYL;VGDQMVVLMDPGEDPEDT;VLQLTKSSGKSFF;VSMSYLEIYNEV 9 13.9 1.0029 -0.85237 10.7605 6.60702 10.5716 10.4219 0 8.80151 0 10.6871 0 0 10.1367 10.2807 0 0 0 A0A8C0TBK8 A0A8C0TBK8_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]" DEDEDEGTDEEN;GPAATPSHTPAPT;PDGLMIPEDGINNE 3 3.9 0.9902 -0.51601 0 0 0 0 0 0 0 0 9.77818 0 0 0 0 0 0 A0A8C0TBK9 A0A8C0TBK9_CANLF J domain-containing protein DNAJC13 Canis lupus familiaris (Dog) (Canis familiaris) endosome organization [GO:0007032]; regulation of early endosome to late endosome transport [GO:2000641] AIIRPLPRVKRLL;ALMCPMHDDYD;DKLIGPKVRI;EVKYECLAEEI;GDKEIATKMQELALSE;GVKVVKALKR;HLHVSRATVPLQ;HVSRATVPLQS;LPEAMVCYLEN;NRMFQKEQSELVAQALKV;RLAGKAAKEVEKFAKEKVDLV;SSCCWRYNCYKHH;SSLPPPVD;STTVREMMLEHFKN;VGEIFVRVY 15 8.3 1.0029 -2.4928 10.4077 0 5.0177 7.30861 8.42761 7.30743 10.725 4.49128 8.34603 6.91253 10.9268 0 10.1308 0 10.2323 A0A8C0TBL5 A0A8C0TBL5_CANLF tRNA-queuosine alpha-mannosyltransferase (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) GTDC1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] ALRPDLGKLKKIL;LSKRLQNFC;RKHLYKIL 3 6.5 1.0039 -1.1044 0 0 5.53646 0 0 4.5698 0 0 0 0 0 5.17636 5.22269 6.21675 0 A0A8C0TBL9 A0A8C0TBL9_CANLF Arf-GAP domain-containing protein AGFG1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AFGQSSGSS;EEKHLKMLRDM;GASFAAFGQTK;PEQAKVVASVHASI;TAFSQQPNGAS 5 9.2 1.0027 -1.3491 0 0 0 5.7419 0 0 13.4433 0 0 9.74446 0 0 0 0 9.22016 A0A8C0TBN7 A0A8C0TBN7_CANLF Polyamine modulated factor 1 SLC25A44 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059] MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634] LDRIVEEGKD 1 4.9 0.85738 0.15986 0 0 0 0 0 0 0 0 0 0 11.6886 11.3541 0 0 0 A0A8C0TBP3 A0A8C0TBP3_CANLF Focadhesin FOCAD Canis lupus familiaris (Dog) (Canis familiaris) regulation of post-transcriptional gene silencing [GO:0060147] EGDVIQVISVSG;ELDEDEDDEGDE;EYENFKVQVLSFLWTH;GLVALVAQDHAEFSYV;LSPKLSCDT;LVSAPLWIKH;PEVQPNFLSMKEWV;QDRVYPELQ;RPLILKTLSELF;TNKQPGLKP;VEHKERDTLAWMVLHS;VLYNDILYTLPSL;VTGGKKGP 13 8.8 1.0028 -2.5697 0 0 7.29517 9.52945 0 0 10.2411 0 10.2517 5.84071 11.7267 9.91039 0 0 9.45978 A0A8C0TBP7 A0A8C0TBP7_CANLF Annexin ANXA3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipase inhibitor activity [GO:0004859] AYYTVYKKSL;PSAPRTAAPQVSVI 2 7.1 0.99219 -0.17725 0 0 7.60999 0 0 0 0 0 0 0 0 0 10.7515 0 0 A0A8C0TBQ0 A0A8C0TBQ0_CANLF Secretory phospholipase A2 receptor (180 kDa secretory phospholipase A2 receptor) (M-type receptor) Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] KEGSNLLTIKDEDENSFLLEELSAF;LVASWKYL;MVPLAVAL;PSFEFVCVWLRG;WSSTACESFL 5 4.3 0.97873 0.035538 0 0 0 0 0 8.43863 0 0 0 0 0 0 0 0 0 A0A8C0TBQ5 A0A8C0TBQ5_CANLF "Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]" mitochondrial respiratory chain complex IV [GO:0005751] DNIASMWKSCSLNPDYKVLL 1 19 0.95443 0.050692 0 0 10.4384 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TBR1 A0A8C0TBR1_CANLF WDFY family member 4 WDFY4 Canis lupus familiaris (Dog) (Canis familiaris) AWQHYLASEKKSLSN;CSWKEPTFCVLR;DAGSDPQGNV;DVATTYSK;EDAGSDPQGNV;EKEFQPLDVMEPEDDPEPSAGR;GLLGLLLAQLRKRAKILRK;GVFRHILCNFELWMNTADNLE;HLMQHIRGYQIMAF;HPSTTVLGLKLL;HQHFYICEN;IQALPGPFLSMDPSSFVDVY;KPSKTSPAVTALAV;LVIATTCLREHSCCSWK;PLIRSTILGF;SSFVDVYGYISTP;VIMHPGIL 17 6.6 1.0045 -1.1044 0 0 0 0 0 0 0 0 7.38172 0 0 0 0 0 0 A0A8C0TBR2 A0A8C0TBR2_CANLF Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) CWC22 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] RNA binding [GO:0003723] DPNFMENEEKYK;EESDSSSSSSQ;LDEGDSDSNTDQDA;QFTHMLPLE;TDQDAGSSEEEEEEEDEEGEE;TDRKRSRKSPTPG 6 8.6 0.98677 -0.35729 7.78927 7.91307 0 0 0 8.10737 0 9.89279 0 9.68884 0 0 0 0 0 A0A8C0TBR9 A0A8C0TBR9_CANLF phosphoinositide 5-phosphatase (EC 3.1.3.36) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] phosphatidylinositol phosphate phosphatase activity [GO:0052866]; RNA binding [GO:0003723] AMAERQSEFTNFRRIRIATGTWNV;GPSKPEPPAGAAL;QEEAKEEDRLVALRKILN 3 4.3 0.98547 -0.44299 0 0 0 0 9.36043 7.48051 0 11.3844 0 0 0 0 0 0 0 A0A8C0TBU1 A0A8C0TBU1_CANLF Transmembrane protein 123 TMEM123 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TGSFLGGI 1 4.6 1.004 -1.1044 0 6.42806 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TBW4 A0A8C0TBW4_CANLF Proline rich 13 PRR13 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] WNPNAGQP 1 5.6 1.0031 -1.1044 0 0 0 0 0 0 0 9.079 0 0 0 0 0 0 0 A0A8C0TBW7 A0A8C0TBW7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] KLLRVLVLVALPL;LMMVTMVFLMCF 2 16.9 0.99365 -0.044883 0 0 0 8.98085 0 0 3.35783 0 0 14.4118 0 0 0 0 0 A0A8C0TBX6 A0A8C0TBX6_CANLF BZIP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ADRTLEVMRQQ;FGGPRRIGKACLRGSDCGAL;YVEMYPVEYP 3 7.9 0.98404 -0.25342 7.05886 0 0 10.151 0 0 9.34123 0 0 0 0 0 0 0 0 A0A8C0TBY6 A0A8C0TBY6_CANLF Cathepsin C exclusion domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GPLLSAALLLLSGFRAA 1 12.5 0.98675 0.046227 0 6.86071 0 0 0 0 0 6.21313 6.40708 0 0 0 0 0 0 A0A8C0TC16 A0A8C0TC16_CANLF POU domain protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EIAKELNYDREVVRVWFC;EQVIVMSGHETIRV 2 5.2 0.99421 -0.12472 0 0 0 8.93307 0 0 14.0882 9.89491 0 0 13.6168 0 0 0 0 A0A8C0TC22 A0A8C0TC22_CANLF SS18 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; positive regulation of dendrite morphogenesis [GO:0050775] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] HYNSAQGGSQHYQGQSS;RNLVYLATIADSNQNMQS 2 8.8 0.98491 -0.44419 0 0 9.14318 0 0 0 0 10.8899 0 0 0 0 0 0 0 A0A8C0TC23 A0A8C0TC23_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FVWPTIPVAPEMT;MVLQGGHTTDYLF;PVAPEMTGQVNMI;TYVVVTVC 4 3.9 0.98954 -0.52625 0 0 0 0 7.37938 0 0 0 0 0 0 0 0 0 0 A0A8C0TC36 A0A8C0TC36_CANLF Shugoshin 2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059] "chromosome, centromeric region [GO:0000775]" DKQPSQQNESKNKKLRQ;DNLLSNQKNKETTS;GYSMEIDNNEKENCDQNSNPYKL;IGKKLRQKVCRKTEIISEINQ;KSKILAKGKKKCISQLPD;NDDDDDDD;NFALESSPIFQISGDV;NRRTEIISEVNHLGNDKNVYCPEK;TDPSEFQTPALS;VSLASKIKTKIL;VTDKQPSQQNE 11 13.7 0.98634 -0.42026 0 0 5.2535 12.4138 0 5.33077 0 0 0 0 0 9.49273 11.7703 17.0245 0 A0A8C0TC58 A0A8C0TC58_CANLF Beta-defensin Canis lupus familiaris (Dog) (Canis familiaris) KPLLVVLILL 1 15.4 0.99964 -0.61146 0 0 0 0 0 0 0 0 0 0 0 4.56767 0 0 0 A0A8C0TC74 A0A8C0TC74_CANLF SH3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin filament polymerization [GO:0030833] actin filament [GO:0005884]; cortical actin cytoskeleton [GO:0030864]; plasma membrane [GO:0005886]; site of polarized growth [GO:0030427] actin filament binding [GO:0051015] AGTGAGISAIALYDYQ;HQLRNKVS;PPALPPRTL;VGFDYKGEVEKHASQK 4 11.1 1.0012 -0.93665 0 0 0 0 0 0 0 0 8.97261 0 0 7.97837 10.9301 9.86714 0 A0A8C0TC78 A0A8C0TC78_CANLF Protein KRI1 homolog Canis lupus familiaris (Dog) (Canis familiaris) CMYRSEQEELQ;KKQEDFEHKYNFRFEEP;KQEELKQLKNLKRKEILAKL;PDFNMDADYDPS;SEDDSAGEGGSG 5 13 0.77568 0.2308 0 0 8.09228 0 0 0 6.45674 0 0 0 8.68724 0 0 5.29042 0 A0A8C0TC82 A0A8C0TC82_CANLF Sm domain-containing protein ATXN2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GGGGAAPG;GGRGGGGG;IENSSSNCTSGSS;LVQHVPHYQSQHPH;NGGGASLP;NSEEFLKREARANQL;VGSKCEVQVKNGGIY 7 6.1 1.0029 -2.5496 8.67885 8.57762 0 13.7362 0 0 12.6206 8.63786 7.82877 0 0 0 8.48022 0 8.52026 A0A8C0TC97 A0A8C0TC97_CANLF Collagen type XII alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] IETGEKSLPG;IVDDLTIN;LSQYRIIYS;PGDEHPPHARW;SGESKEVTTPA;SYSFKANWSPAGENV;TDQGTTLYLNV;VTDLKTYQIGWDTFCVR;YALSVTALYASG;YKVEYYPVSGGKRQEFYVSR 10 4 1.0027 -1.3547 11.5972 7.40965 11.8327 10.2183 0 0 11.8201 11.8895 11.4945 11.7782 0 11.5339 0 0 10.5206 A0A8C0TCA9 A0A8C0TCA9_CANLF Potassium sodium-activated channel subfamily T member 1 KCNT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] DYYVVILCP;ESPEQWQRMYGRCS;GGGGGGGG;GGGGGGGGK;HPDTASLKMSDLDS 5 3.7 0.99104 -0.21001 0 0 0 0 0 0 13.2725 0 0 0 0 0 0 0 0 A0A8C0TCC7 A0A8C0TCC7_CANLF E2F/DP family winged-helix DNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DICNCFNG;PPLGRGLRPRSPG 2 5.7 1.0045 -1.0448 0 0 0 0 0 0 0 0 0 0 6.2707 0 0 0 7.54226 A0A8C0TCD4 A0A8C0TCD4_CANLF beta-ketoacyl-[acyl-carrier-protein] synthase I (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase) OXSM Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315] GVAIGMGMVPL 1 2.9 0.98224 0.035491 0 0 0 0 7.29444 0 0 0 0 0 0 0 0 0 0 A0A8C0TCE4 A0A8C0TCE4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DGDSPEEIAA;DQHQPFLFRH;EEKYDEAVD;LCLSSEES;LLGFSPSA;SRQILRGLHFL;VSSNLPQH 7 5.4 0.99714 -3.9263 9.15947 0 0 4.93763 11.5355 0 0 9.30118 0 0 0 10.1595 10.7562 8.76792 8.93643 A0A8C0TCE6 A0A8C0TCE6_CANLF RanBD1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; positive regulation of mitotic centrosome separation [GO:0046604] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear pore [GO:0005643] GTPase activator activity [GO:0005096] WNTHADFADECPKPELLAI 1 9.5 0.94906 0.04956 0 0 8.6643 0 0 0 0 0 7.40922 0 0 7.86771 0 0 0 A0A8C0TCF2 A0A8C0TCF2_CANLF Sugar phosphate transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EKPFLLRALQITLVVSLY;FWLGVDQEGAEGTL;TSFYALLTCGII;YPGWPGYWGWG 4 10.2 1.0001 -0.61599 0 9.65152 0 0 9.19431 13.1369 0 0 0 0 0 0 0 0 0 A0A8C0TCF4 A0A8C0TCF4_CANLF TAFH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352]; transcription by RNA polymerase II [GO:0006366] transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982] AVQPAPAPPQALATSCPAGA;KDEQEREILMRAAKSRS;LVIQQPPKPGALIRPPQVTLT 3 5.5 0.85064 0.14825 8.32984 0 0 0 0 6.90436 0 10.0051 0 0 0 0 0 0 0 A0A8C0TCG8 A0A8C0TCG8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PAAASWRRPESGRTTAPSTAT;VYLHFGHKLLAQLLGTSEE 2 13.4 0.96098 0.04885 0 6.67652 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TCI3 A0A8C0TCI3_CANLF Ubiquitin-like domain-containing protein UBQLN4 Canis lupus familiaris (Dog) (Canis familiaris) DAGSGSRRSSGGGPSPGA;GSGSRRSSGGGPSPGAGEGP;PGPQHPWQA;VPLFAGNPQL 4 5.7 1.0031 -1.5009 8.58823 6.96197 0 0 0 0 11.2282 0 0 0 0 0 0 0 0 A0A8C0TCI7 A0A8C0TCI7_CANLF Cadherin domain-containing protein PCDH17 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AMITIAVKCKRENKEIRTYNC;GGGGGGGG;NHHTLVLTALDGGE;VTPVVELV 4 5.8 0.9879 -0.48912 0 13.3187 13.3116 0 0 0 0 13.3618 0 0 0 13.477 0 0 4.62293 A0A8C0TCI8 A0A8C0TCI8_CANLF Stereocilin Canis lupus familiaris (Dog) (Canis familiaris) AGLQAVPPSNQAWVQ;AMDLAWKRIQETLETSSL;EGLLRVTDSLRNEVFS;FLGHQAGVL;QALVQVQPS 5 9.5 0.98484 -0.25773 0 0 0 0 0 0 0 0 10.8769 0 0 0 0 0 0 A0A8C0TCJ6 A0A8C0TCJ6_CANLF "Inositol 1,4,5-trisphosphate receptor" ITPR2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666] cell cortex [GO:0005938]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sarcoplasmic reticulum membrane [GO:0033017] "inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]" DLEVLTYYRYQLNLFARMCLDRQYL;FDNKTVSFEEHIKSEHNMWHYL;KKRDDDNEL;KSEHNMWHY;VTQELICKFMLSPG 5 2.6 1.0005 -0.92949 0 10.9251 0 0 10.8846 0 5.97377 0 0 0 6.18595 0 0 10.4217 0 A0A8C0TCL2 A0A8C0TCL2_CANLF Anion exchange protein SLC4A8 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AIVFPMMVLALVFVRKVM;DQVTVLPPGEWDPS 2 3.2 0.97348 0.048313 0 0 0 0 0 0 0 6.11871 0 0 0 0 0 0 0 A0A8C0TCM0 A0A8C0TCM0_CANLF Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein TEX10 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ANVRLAAVQLLQFLAP;LDILLEQYPALIT;PLLIECWIEAVPP;SEVTAVFTDKDANV;SQSFDILQSA;TLSDIMVSLANASTL;VGGLGSVDEGLSSTENLKG;VGQLLRLLLQHAPLRTH 8 12.5 1.0018 -1.2505 0 0 0 7.61743 0 12.3147 0 0 0 0 0 0 12.7498 0 0 A0A8C0TCN2 A0A8C0TCN2_CANLF Ornithine aminotransferase (EC 2.6.1.13) OAT Canis lupus familiaris (Dog) (Canis familiaris) arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; ornithine aminotransferase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170] ALSGGLYPVSAVLCDD;FWGRTLSA;IFERESKYGAHN;STDPSSYD;SYDGFGPFMPGFE;YDAWKVRWDS 6 14.8 1.0015 -2.684 0 0 7.31415 8.62943 8.56628 0 0 0 0 7.65234 0 0 0 7.47565 0 A0A8C0TCV2 A0A8C0TCV2_CANLF Zinc finger and BTB domain containing 8B Canis lupus familiaris (Dog) (Canis familiaris) AAAVAAHQVDSGSP;SGGPPAHSVLPALGTKASTLGR;VLVVPIKLH 3 6.7 1.0013 -0.92544 0 19.4266 0 3.45035 0 0 0 0 7.40565 0 0 0 0 0 0 A0A8C0TCV3 A0A8C0TCV3_CANLF ATPase H+ transporting accessory protein 1 ATP6AP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APALRQMR;VAAAEQQVPLVLWS;VLLFLQDK 3 6.5 1.0038 -1.6834 0 0 10.6737 0 0 0 3.39506 0 0 0 0 0 0 0 0 A0A8C0TCV5 A0A8C0TCV5_CANLF Solute carrier family 13 member 2 SLC13A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] solute:sodium symporter activity [GO:0015370] AYRSYLIVLLL;EVCIEYFKDSNI;IVLLLPILLLPLPILIP;IVLLLPILLLPLPILIPT;LIVLLLPILLLPLPIL;LIVLLLPILLLPLPILI;LIVLLLPILLLPLPILIP;LIVLLLPILLLPLPILIPTK;LIVLLLPILLLPLPILIPTKE;MAILLLLSWLWL;RIALRVLLIIGVRPALL;VLLLPILLLPLPI;VLLLPILLLPLPILI;YLIVLLLPILLLPLPILI;YLIVLLLPILLLPLPILIPTK 15 11.3 0.94467 0.077407 0 7.71699 5.20945 0 8.64151 4.88548 11.0072 10.7622 7.05376 0 8.57501 0 4.05832 6.01534 7.76029 A0A8C0TCV6 A0A8C0TCV6_CANLF ISL LIM homeobox 2 Canis lupus familiaris (Dog) (Canis familiaris) neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CRADHGLLLERAAAGSPHSPGP;DTEGLGRPLRPLREPLVLVREPL;DVTSLSSQL;EKTTRVRTVLNE;EKTTRVRTVLNEKQLHTLR;EVQTYQPPWKAL;SGSDVTSLSSQLPDT;VGERPPAEPEPEG 8 15.3 1.0011 -0.94381 0 4.7426 0 6.32454 0 0 0 0 9.77243 0 0 8.78594 0 9.47634 0 A0A8C0TCW3 A0A8C0TCW3_CANLF TGF-beta family profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] MHAVDPEI;PSILKKIF;PSILKKIFQ 3 4.7 1.0032 -1.9447 0 10.1897 0 0 0 0 0 0 0 0 4.73558 4.15251 0 0 0 A0A8C0TCW5 A0A8C0TCW5_CANLF Semaphorin 3E Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor binding [GO:0030215] AICVYHMSSIRAAFNGPY;ESMEEVIL;GSACADCC;IFGLFNTTSNIFRGHAICVYHMSSI;IFHSPFGFLDLHAML;MATVTRATLFVSLCGP;RARPEHYRVPRHTR;SLCGPKTTSCIPLS 8 10.5 0.9986 -3.0211 0 11.7048 0 0 0 10.6599 0 12.5073 0 0 0 4.67711 0 0 0 A0A8C0TCW6 A0A8C0TCW6_CANLF Eukaryotic translation initiation factor 4C EIF1AX Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] DDDEDIDDGCLGD;GDDDEDIDDGCLGD;LPEHAKINETDT 3 16.9 0.99292 -0.16893 8.88423 9.33336 0 0 0 0 8.57452 8.64634 8.89102 0 0 0 0 0 0 A0A8C0TCX2 A0A8C0TCX2_CANLF "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1)" Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [GO:0004741]; metal ion binding [GO:0046872] FPLLRNCELSRIYG;GMLLGVFDGHAGCACSQ;GRCCCRCCCP;RAFGDVKFKWSI;SSVFEDQNAATHLIRH;VGASAPVL;VIESGPDQLN 7 13.1 1.0031 -2.3515 0 10.634 7.92641 0 0 0 12.2617 0 0 0 6.06878 0 8.95629 0 0 A0A8C0TCY0 A0A8C0TCY0_CANLF Fibrillin 3 FBN3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] ACPRGYLLEEDGR;EDVDECVSVLGLCS;EEELLSSEACYE;GCSDVDECEL;LCVDMRLEPCF;LVCEDMNECASGESPC;NCPQDFELNP;PQSNSRDGCTDEDEC;PSSYRCECNAGYTQDVRGEC;QVNGGNNCMDMRKSICFRHYNGT;RCECEMGF;RCGCPQGF;RRGFIPNVRTGACQDVDECQTVPGL;SQCVDENECVLSPAACGSASCH;VDVDECARNSLLCDN;VGPGPGPA;VGSFRCSCAGGFAPD;VILEDIDE 18 8.9 1.0027 -2.4682 9.39915 8.26637 0 0 10.6473 0 9.70684 11.9012 0 10.1169 3.05636 0 8.76686 0 5.89872 A0A8C0TCZ2 A0A8C0TCZ2_CANLF Serpin domain-containing protein SERPIND1 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ETYEQVHSILHFKDFVNASSKYE;FSEDDDYI;GQLEEGGEDSPSRD;GQLEEGGEDSPSRDSQ;LEEGGEDSPSRDSQW;YEHRTSCLL 6 11.5 0 9.8523 9.68774 10.9268 9.32465 6.52521 6.80967 0 9.51134 9.91812 9.09162 9.0047 9.2546 9.12895 10.4332 9.46769 9.87126 A0A8C0TD04 A0A8C0TD04_CANLF Polybromo 1 PBRM1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] RSC-type complex [GO:0016586] chromatin binding [GO:0003682]; DNA binding [GO:0003677] CKLWDLYLRTRNEFVQ;DEDDDEDGQDNQ;EADDEDDDEDGQDNQGT;EDAVELQQF;FEQLRYNDMWL;GLVSMGSMQPLHPGGP;IHPEETEHEPTKMFYKKEVFLSN;IYEDAVELQQFFIKIRDELCKN;KPIVPQKEP;LEETCPMTCI;LMLRDTLNIRQAYNLENL;NTIRDYKDEQGR;VPVEMSNGEPGCHYF 13 10.5 1.0035 -1.6526 0 0 11.5825 0 8.82814 8.40646 0 5.8836 9.12781 6.9507 9.15679 0 0 5.21498 0 A0A8C0TD25 A0A8C0TD25_CANLF High mobility group AT-hook 1 HMGA2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of macromolecule metabolic process [GO:0010604]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677] RSLLRRRLKRH 1 4.8 0.98086 0.035491 0 0 0 3.115 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TD28 A0A8C0TD28_CANLF Tyrosine-protein kinase (EC 2.7.10.2) TYK2 Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556] cytoskeleton [GO:0005856]; membrane [GO:0016020] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] EAGKTKSKAPA;IFRRFVRAFQP;LKKIRDLGEGHFGKVSLYCYDPTN;LVHGNVCGRNIL;QAEQGVQLLDPASFE 5 6 1.002 -0.69257 9.67871 0 11.1584 0 0 4.37921 0 0 11.9522 0 0 0 0 10.4694 0 A0A8C0TD42 A0A8C0TD42_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AACTEYME 1 2.3 1.0034 -1.1044 0 4.86007 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TD74 A0A8C0TD74_CANLF Bestrophin BEST1 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254] GSTFNINLHKE;ILRTQCGHLF 2 3.6 0.99178 -0.27669 0 0 0 0 8.96385 0 0 0 0 0 0 0 0 0 0 A0A8C0TD80 A0A8C0TD80_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP11B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AKVIRLIKISP;FYFLIIFLVQL;LREHEKLFME;LSSDRLDG;LYVTVEMQKFLGSF;MSVIVQAPSGEKLLF;SYFLIGKDISLLGNGQ;TAIKQGYEDWLRHNSDNEVNGAP;VQSAQHMNL 9 10.1 1.003 -2.2025 0 5.92493 0 0 0 5.99946 9.47567 0 0 0 0 0 0 0 12.2306 A0A8C0TDF9 A0A8C0TDF9_CANLF Malic enzyme ME3 Canis lupus familiaris (Dog) (Canis familiaris) "malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" GAVPRWTPSAPGR 1 2.4 0.98432 -0.25302 0 10.2904 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TDH0 A0A8C0TDH0_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LILIGIGGGFMILYYVA 1 2.5 0.97657 0.046227 0 0 0 0 0 0 8.16486 0 0 0 0 0 0 0 0 A0A8C0TDH9 A0A8C0TDH9_CANLF E3 ubiquitin-protein ligase RNF10 (RING finger protein 10) RNF10 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] QYSKLLLASKEQVLHR 1 2.1 0.9608 0.049233 0 0 0 0 0 0 0 0 10.1857 0 0 0 0 0 0 A0A8C0TDK2 A0A8C0TDK2_CANLF Zinc finger protein 252 ZNF252 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KCVKREDLLTA;NNPEKSFECTEC;SSLHLPFHPPPW 3 3.5 0.99012 -0.51625 0 0 0 0 0 0 0 0 0 0 0 10.4432 0 0 11.3185 A0A8C0TDL9 A0A8C0TDL9_CANLF C2H2-type domain-containing protein SP1 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EACTCPYCKDSEG;LAVERVFKIL;SSSGGGGG;SSSSGGGG;VGGNNGGN 5 5.2 0.99971 -0.61146 0 0 0 0 0 0 0 0 5.54282 0 0 0 0 0 0 A0A8C0TDN6 A0A8C0TDN6_CANLF Synaptosomal-associated protein 29 (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] autophagosome membrane [GO:0000421]; ciliary membrane [GO:0060170] GAGRRAAEPRGCRAV 1 4.4 0.94874 0.053909 0 0 9.47192 0 0 0 0 8.35592 0 0 0 0 0 0 0 A0A8C0TDQ0 A0A8C0TDQ0_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) HLSCEACCFHWW 1 5.2 0.94151 0.05044 0 0 0 0 0 0 9.56495 0 0 0 0 0 0 0 0 A0A8C0TDQ1 A0A8C0TDQ1_CANLF Transmembrane protein 108 TMEM108 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSRAGQGD;PTRATTRRPPRPPGSSRKGAN;TSSTSQAPSHPTEG 3 8.1 0.98645 -0.42445 0 5.62179 0 0 0 0 10.9538 0 0 0 9.22983 0 0 0 0 A0A8C0TDR5 A0A8C0TDR5_CANLF Resistin-like beta Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] hormone activity [GO:0005179] GCACGYGCGSWDIQG 1 14 0.95238 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.56247 A0A8C0TDS4 A0A8C0TDS4_CANLF CD320 molecule Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CDGDEDCPDGSDED;CDGDEDCPDGSDEDECSEWP;DEDCPDGSDEDEC;DEDCPDGSDEDECSE;GDEDCPDGSDEDECSEW;PDGSDEDECSEWPITGSPCPCD;SEWPITGSPCPCDNIDDC;SPCPCDNIDDCRDGIVDNVYNCSY;TLRCDGDEDCPDGSD 9 21.3 0.9941 -0.15599 0 0 10.8288 0 5.55698 6.02498 5.2458 7.8967 0 0 11.0558 0 0 0 4.98791 A0A8C0TDS6 A0A8C0TDS6_CANLF Serine protease 23 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] DIGMDYDYAL;IPGLLFLLLLLLLCAVGQ 2 8 0.99246 -0.16864 0 0 12.3356 0 0 0 0 0 0 0 6.63757 0 0 0 0 A0A8C0TDS9 A0A8C0TDS9_CANLF Catenin beta-1 (Beta-catenin) Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; positive regulation of transcription by RNA polymerase II [GO:0045944] adherens junction [GO:0005912]; catenin complex [GO:0016342]; cytoplasm [GO:0005737]; nucleus [GO:0005634] alpha-catenin binding [GO:0045294]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; protein phosphatase binding [GO:0019903]; transcription coactivator activity [GO:0003713] APSLSGKGNPE;DVETARCTAGTLHNL;IVEGCTGALHILARD;KLIILASGGPQALVNI;LDIGAQGEPLGYRQDDPSYR;MFPETLDEGMQIPSTQFDA;NLTCNNYKNKMMVCQVGGI 7 15 0.98761 -0.22787 0 7.86227 0 0 9.41682 0 0 9.79808 5.84765 0 11.3834 0 0 0 9.19879 A0A8C0TDT6 A0A8C0TDT6_CANLF Rho GTPase activating protein 33 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091] EDRSWWRGK;ERLVRVHDVIQ;HRCIFDRRFSCLPEL;LDRGENLYYE;VPPAVLEL;VPQVLRCCS 6 4.9 1.0007 -2.7679 0 0 0 0 0 9.02876 0 0 12.1543 4.91068 0 5.80609 0 0 12.9459 A0A8C0TDW6 A0A8C0TDW6_CANLF Transcription factor 7 like 2 TCF7L2 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DNA binding [GO:0003677] KDEGEQEE;PRSESFRDKSRESLE;RCKYSKEVSGTV;VSNKVPVVQHPHH 4 10.1 0.99185 0.010656 0 0 0 0 0 0 0 12.5331 0 0 0 0 0 0 0 A0A8C0TDX8 A0A8C0TDX8_CANLF SURP motif domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] RNA binding [GO:0003723] APPPPGTTPPPP;GVSSDDDDDEEDGSYLHPSL;SDDDDDEEDGSYLH;VELLVFGYACKL;VPTAYRMSNSPG 5 6.3 1.0019 -0.67108 0 0 9.75151 0 0 0 10.8235 0 0 6.98208 0 0 0 8.42227 0 A0A8C0TDZ1 A0A8C0TDZ1_CANLF DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; lyase activity [GO:0016829]; zinc ion binding [GO:0008270] GPAVPFES;PSAARSRSWARRGP;SRSWARRGPPEQGTAQQP 3 8 1.0001 -0.61686 0 0 0 0 0 0 0 0 12.8628 0 0 9.02547 0 12.0405 10.2551 A0A8C0TDZ2 A0A8C0TDZ2_CANLF LSM family member 14B LSM14B Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729] SELKTSSRRTTWAEER;TDRPAPPREE;VQSQGQVNDENRRPQRRRSGNRR 3 12.7 0.99043 -0.51594 9.84189 0 0 0 0 0 10.4318 0 0 0 0 0 0 0 0 A0A8C0TDZ5 A0A8C0TDZ5_CANLF Spatacsin C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AAGCSSCGAE;ARIDFWKKCHE;CHENFKKNSISSKAASS;CKRAQAFISTQ;CSRSPQELQRNKE;DLLHKKHY;EAYDFVPD;EDSHNGSS;EIIKSSKWEVPCCAPW;ELLKNMGFDVKDQL;ETAATRVHT;FTSLKVSQDLDV;GFVHEASRVCRY;GPFRHFIWE;GVSQVVQDDE;ILFVLSSLGW;IWRTLLTRQKSKTLIRGFQLF;LDYIKRCRPGDSE;LMMEMYELCMFFK;LVQCRQVSSNLTDPKLIF;QQMFAPAEESRTFL;QVGNEAYVLGLS;SCLQDASTI;VLASCLQDASTI;WEKLSIEEVIANAILN 25 12.3 0.97531 0.047166 0 0 0 0 0 0 0 0 0 0 0 0 0 12.2045 0 A0A8C0TE08 A0A8C0TE08_CANLF Ankyrin repeat and SOCS box containing 1 ASB1 Canis lupus familiaris (Dog) (Canis familiaris) GSPGCVMD;QSVWLNRMNRAIVIKKK;VIKKKTKKQ;YHASRVGRAD 4 10.7 1.0018 -1.3175 5.20418 0 0 0 0 9.74829 0 0 0 9.58103 9.25644 9.62529 9.83205 0 0 A0A8C0TE16 A0A8C0TE16_CANLF FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit domain-containing protein KIAA0100 Canis lupus familiaris (Dog) (Canis familiaris) IKMDLTRHSGTISQP;IVNNLLLHV;LMESGQAVGGMVT;PSADPSPPLPWWDKSRLL;QAGTVMRRL;RQLEKQIYSIMKSL;SRHGGSLQAYCPE;VTENLAEPTLPGLYLLQ 8 4.9 1.0022 -0.90255 8.21495 0 0 9.15353 8.88719 12.8453 0 0 10.7962 0 0 0 0 9.71922 0 A0A8C0TE18 A0A8C0TE18_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] LVDGNKFEKTEA;SLYLKEKEYSH 2 13.4 0.94106 0.085931 0 0 0 0 6.25905 0 10.3156 0 0 0 0 0 0 0 0 A0A8C0TE35 A0A8C0TE35_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MARCHF7 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DMMGNTNEPS;GGSPSDSA;NSVSTLQLNTSSTNHQMPSEH;SQNHSSEPDSENFNQESEG 4 9.1 1.0031 -1.9314 0 0 0 3.21277 0 4.18301 9.8084 0 0 8.9622 9.49141 0 7.78647 0 0 A0A8C0TE36 A0A8C0TE36_CANLF Leucine rich repeat and coiled-coil centrosomal protein 1 LRRCC1 Canis lupus familiaris (Dog) (Canis familiaris) DLHSLALLTTDRL;ENEDGDSSCGDCASWT;GDSSCGDC;HTKNNNPFMSCNRKMKQPFFK;IVEAHHAEIIQL;LISNRGKLEAQIESL;TLEILIEDDKQKSIQ;VENEDGDSSCG 8 9.7 1.0036 -1.0552 0 0 0 8.77551 0 0 0 0 0 0 4.46231 0 0 0 0 A0A8C0TE57 A0A8C0TE57_CANLF Histocompatibility minor 13 Canis lupus familiaris (Dog) (Canis familiaris) membrane protein proteolysis [GO:0033619]; signal peptide processing [GO:0006465] endoplasmic reticulum membrane [GO:0005789] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" APIKLVFPQDLLEKGLEADN;YESSAEILPHTP;YLFFKIFSQEYIN 3 11.4 0.9898 -0.21209 0 0 0 0 0 0 0 0 5.37016 0 0 0 0 0 7.2426 A0A8C0TE79 A0A8C0TE79_CANLF SWIM-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CARYLFTALLPHDPDLAY;DAHLQRILASDSYGPSL;DTTLLGIALE;ELSAIVPLI;ETFLLAPDGHLQFAQFLE;GGPGEPERLYHVSISFDRC;LFYCAHVVA;PDGHLQFAQFLENLKQTY;PISETLSQMNRDQLQ;RALQAGSLHWSDAHLQ;SEREICMYSSLGYQ;VLGSIQQNIH 12 14.7 1.0031 -1.7315 0 11.0778 0 6.17716 0 12.0462 6.32605 0 8.94357 0 0 5.44095 9.68988 0 5.60324 A0A8C0TE84 A0A8C0TE84_CANLF Enhancer of polycomb homolog EPC2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777] FNLDNEQPDYDMDSED;GGITEEQFQTHQQQLVQ;GWGWPGDG;KRREKTKRELLHL;TLPVINKSDIKQ 5 7.8 0.94211 0.05044 0 0 0 0 0 7.21306 0 0 0 0 0 0 0 0 0 A0A8C0TE86 A0A8C0TE86_CANLF Caspase 7 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] AADTMADDQDCGMEQAAGD;GPAPGPAPAPPQTPT;GVQSAPPG;LEKPKLFFI;PLPRVGGP;PPAAADTMADDQDCGME;TAQDQVPTYQYNMNF 7 10.8 1.0032 -2.3253 0 0 0 0 0 0 6.38087 0 0 0 9.56824 0 10.366 7.83674 0 A0A8C0TE91 A0A8C0TE91_CANLF R3H domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] FFMEELPGEKDFAH;LLCLDGVFLSSAENDFVHR;RPKLLRLAKVRPQT;RPRACCSLAQGGGEGV;SGGGGGGA;SLAQGGGE 6 11.7 1.0028 -1.1438 0 0 0 0 0 0 0 0 0 10.5169 0 10.5184 0 0 0 A0A8C0TE92 A0A8C0TE92_CANLF ADAM metallopeptidase domain 20 LOC486076 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EEGEECDCGS;PDSLVSLSTCSGGFQGILQ;SYQCPEDVYVQDGV 3 5.7 0.98754 -0.36961 0 0 0 9.81509 0 0 0 0 0 0 0 10.0606 0 0 0 A0A8C0TEA6 A0A8C0TEA6_CANLF Pleckstrin homology domain containing A7 Canis lupus familiaris (Dog) (Canis familiaris) DYDLDISRELSKPE;ERREQEEERYR;FILQEEPHPHMSKQ;PRGPAQAEPAAPPP;RMKRHQKALVRERKRTLSQGERTGL;WNEYLKLES 6 6.4 0.9852 -0.24511 0 0 0 0 0 0 0 9.32465 0 0 9.67145 0 9.52276 0 0 A0A8C0TEB0 A0A8C0TEB0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] ELFDGQQL;ELFDGQQLQENV;PCVNYTND 3 11.4 1.0021 -1.2764 0 0 0 10.7108 0 0 0 11.9849 12.045 7.22593 0 10.6567 0 11.3525 0 A0A8C0TEB2 A0A8C0TEB2_CANLF Transcription factor SOX Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" EAERLRLKHMADYPDYK;EDDDEDDDEELLEVRL;GGGGGGGG;PGGGGGGG;PPGGGGGGG 5 15 0.95487 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.99977 A0A8C0TEF3 A0A8C0TEF3_CANLF Beta-defensin Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular region [GO:0005576]; membrane [GO:0016020] TSHAGPHVKRATY 1 11.1 0.94019 0.059711 0 0 0 0 0 0 0 0 0 0 0 0 5.19476 0 0 A0A8C0TEF5 A0A8C0TEF5_CANLF LY6/PLAUR domain containing 6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical Wnt signaling pathway [GO:0090263] acetylcholine receptor inhibitor activity [GO:0030550] AQSASPTAD 1 4.9 0.98455 -0.25303 0 0 0 0 0 0 0 0 0 0 0 0 9.54326 0 0 A0A8C0TEG6 A0A8C0TEG6_CANLF Interleukin 1 receptor accessory protein like 2 IL1RAPL2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] hydrolase activity [GO:0016787] ALIFDSVVEADLANYT;ESLKRSIKLLSLIKWKGP;QEVQEEDG;SLKRSIKLLSLI 4 6.1 0.98788 -0.48747 0 9.622 0 14.8544 0 0 0 4.32647 0 0 0 0 0 0 0 A0A8C0TEI2 A0A8C0TEI2_CANLF Talin 2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; ruffle [GO:0001726] actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200] ASNPEFVSIPAQ;ERELEEARKKLA;IVNRLEAVAD;LFLSDEDPRKGIWL;PEESIRMTKG;SQLIAGYIDIILKKK;STSQLVACA;TEKVSLVLS;TESIFSSMGDAGEM;VGSIPANAADDGQWSQ;VLKAKNVAQV 11 5.2 1.0016 -2.6479 11.2233 0 11.2761 0 0 0 4.16277 0 9.82799 10.9089 0 0 11.7292 7.14547 11.1173 A0A8C0TEJ1 A0A8C0TEJ1_CANLF Oxysterol-binding protein Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] cholesterol binding [GO:0015485] ARSEQEGDGKDKKDEEE;GSGGHELSALGGEG;HVIPGSKL;MPIAFNEPLSFLQRITEY 4 6.5 1.0036 -1.6474 10.1527 10.511 0 0 0 0 9.41488 11.926 9.01095 0 0 0 0 0 0 A0A8C0TEL1 A0A8C0TEL1_CANLF glycerol kinase (EC 2.7.1.30) Canis lupus familiaris (Dog) (Canis familiaris) glycerol catabolic process [GO:0019563] membrane [GO:0016020] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" KPSMPETTALGAAMAAGAAEGVGVW;SGLYAPFWEP 2 6.6 0.98997 -0.26662 0 0 0 0 0 0 0 0 0 0 0 0 15.6353 0 0 A0A8C0TEM3 A0A8C0TEM3_CANLF Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) NECAP1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] clathrin-coated vesicle membrane [GO:0030665]; plasma membrane [GO:0005886] LLRKKRLQKNSHSI;LTLLRKKRLQK 2 5.2 0.92837 0.09626 0 0 0 0 0 0 0 6.36333 0 0 0 0 0 0 3.68583 A0A8C0TEN0 A0A8C0TEN0_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] LDPGGCPGG;LRLVGTLLPGQ;PLVSEEAQSCLCQAGEPPA;REVCTPPSP 4 11.5 1.003 -1.5232 8.67539 0 0 0 0 0 7.10696 0 0 5.97329 0 0 0 6.29679 6.21066 A0A8C0TEN2 A0A8C0TEN2_CANLF ADP ribosylation factor like GTPase 13B NSUN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DFDTLNERIQRDI;DTLNERIQRDITEQRALEEQ;HKVEHEQIETQ 3 6.8 0.99219 -0.19183 0 0 6.91217 0 6.21239 0 0 0 0 0 0 0 0 0 0 A0A8C0TEN3 A0A8C0TEN3_CANLF CUE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin binding [GO:0043130] CMGAAAALGPPVCGVEL;EDEYDDTYDGNQVGANDADSD;EGQEEDEEEEEEEAEDEA;LRMSTHKE;SRKKLLEIFHI;YRGDDYEDEYDDTY 6 11.6 1.0022 -0.65177 0 0 8.60637 0 9.07114 0 0 9.10397 7.48905 9.56685 0 0 7.86183 0 0 A0A8C0TEN7 A0A8C0TEN7_CANLF PID domain-containing protein PID1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of cell population proliferation [GO:0042127]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377] cytoplasm [GO:0005737] VSPNIFAWVYR 1 5.4 0.99009 -0.20495 0 0 0 0 0 0 0 11.1198 0 0 0 0 0 0 0 A0A8C0TEN8 A0A8C0TEN8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAMESSRCS;AGLEGPTVPHEAQGA;GCSEASVEGS;GVSVAGSGCSGASMEGSRHS;SGASLASSGCSEASVEGS;VAGSGCSEA;VEGSRHSRTSVAGSGHSGASVA 7 10.8 1.0041 -1.993 0 0 0 9.36864 0 9.93948 0 0 9.32333 0 10.4146 0 0 8.46756 0 A0A8C0TEP3 A0A8C0TEP3_CANLF Integrator complex subunit 8 INTS8 Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] ERQFWTVSNKWEVPS;HTQVAILCQF;IDFLLEVCSRS;LNASNPEEVLQ;LTYLHHKRGE;MLLLDIHTHEAGTGQSGERPPSD;SELLSFIKKLREPLVL 7 9.6 1.0009 -0.6341 10.0441 0 0 0 0 9.12725 8.75752 11.8826 9.12642 0 0 0 0 11.8889 0 A0A8C0TEQ7 A0A8C0TEQ7_CANLF RAI1-like domain-containing protein EDRF1 Canis lupus familiaris (Dog) (Canis familiaris) ESEDPSAQGSALF;IHHRLASMYH;ILWTFEDIHMLVGSNMPIFGG;KFLYYSINGDGAAQ;LGEKRKTDFPKETGDWTWLKEFYQR;NIKKLLKIPY;SESPLNENSDESYSEEEEEMPDS;TPIPLKYEDESTRGGPE;VPEKYKSIHQIRPSCTFPVCHDT 9 12.4 0.9909 -0.29762 0 0 0 0 0 0 9.71918 0 0 0 0 0 0 0 0 A0A8C0TER3 A0A8C0TER3_CANLF Cyclin N-terminal domain containing 1 PSME3 Canis lupus familiaris (Dog) (Canis familiaris) LVQQNEQAMQEAAGR 1 4.6 0.98697 -0.23332 0 0 0 0 0 0 0 11.9191 0 0 0 0 0 0 0 A0A8C0TER4 A0A8C0TER4_CANLF UBZ4-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HVFECLDSPPVSETECPDG;HYAGLSKNFTFPVYCSEIT;KIPESPNAGQLRKKT;LSDLEFDA;LSDLEFDAKN;NLNPVVSP;SPAHPSGDCCHETN;VCGKALGG;YFKEWKLEAGY 9 10.2 1.0006 -2.7833 0 12.5578 12.5996 0 0 10.2901 0 5.36082 0 0 8.54932 9.30661 0 0 0 A0A8C0TER7 A0A8C0TER7_CANLF V-type proton ATPase subunit Canis lupus familiaris (Dog) (Canis familiaris) vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034] "early endosome [GO:0005769]; lysosomal membrane [GO:0005765]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" YKSYLEAFYKFCKNH 1 4.3 0.94946 0.053889 0 0 0 6.9216 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TES5 A0A8C0TES5_CANLF Tight junction protein 1 TJP1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] cell adhesion molecule binding [GO:0050839] AAVVPPLI;AVSTPVKHADDHTHKTVEEVVVERN;EQPTYRYDS;FSRNYDHRLRYEERIPTYEEQWSY;GGDRADFW;IDFCELTNTA;KPSTHIPAG;LSSIETGVSIIIPQGAIPE;PDPEPVSENEDSYDEE;PKTLAKAH;PKTLAKAHSAAQP;PSDHSRHSPQQ;SSKAGHYEPLHGAAV;SVSQGKPSLRRIKGRLHR;VSENEDSYDEEVHDP;VVFLNPDSKQGVKTMRMRLCPES 16 12.6 0.99677 -4.6635 9.28755 8.98956 9.67456 0 0 0 12.2561 13.0054 12.6777 8.1234 0 8.33633 11.6981 8.9535 12.8731 A0A8C0TEU5 A0A8C0TEU5_CANLF S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) ADH5 Canis lupus familiaris (Dog) (Canis familiaris) formaldehyde catabolic process [GO:0046294] S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity [GO:0051903]; zinc ion binding [GO:0008270] ATAVCHTD;ECIGNVKVMRAALEA 2 6.2 0.99126 -0.54679 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.7524 A0A8C0TEV3 A0A8C0TEV3_CANLF "Mucin 2, oligomeric mucus/gel-forming" Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] CCNITSCKCNTSLCQET;DPDGCCWHWECDCYC;GCCWHWECDCYC;LDPDGCCWHWEC;LTGTQTSGPPSSKTTPTS;SSTTPPTPPTP;VEEITSKVDNFGVYI 7 8.5 0.9942 -0.1232 4.90963 0 0 0 0 0 0 0 0 0 0 10.0037 0 0 4.09009 A0A8C0TEV6 A0A8C0TEV6_CANLF U1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ADQIAFQVAGGLTAL;AESKKKHE;AESKKKHEEKQ;ANDVLSSEKAGI;ASAIAEEEQLTREIEAEENNDINI;DEIYETCESDQSVV;DESIQKGEFAG;DTRAHQPKGKSLGS;EAMEELQKKIQLKHDESIR;KTDAQSRPT;QARDEAVQE;TCNNCSENCTDVL;VLPPAAAL;WETVQRGRPVRSR 14 13.1 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 4.59723 0 0 A0A8C0TEW2 A0A8C0TEW2_CANLF Synaptonemal complex protein 2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] ESKKLLTIILKNIIKIS;HHTYEGRINKLEKFQF;IEVMRCTEKI;KKLLTIILKNIIKISKRE;PILLTNTSAPRRGRTK;SLKDLEKEFV 6 6 0.96324 0.049233 0 0 8.0404 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TF16 A0A8C0TF16_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465] Cul3-RING ubiquitin ligase complex [GO:0031463] cullin family protein binding [GO:0097602]; ubiquitin-protein transferase activity [GO:0004842] MDYAAKLMKNIRFPLMT;VGGYSWNNRCM 2 4.5 0.97717 0.046227 6.5934 0 0 0 0 0 0 7.2571 0 0 0 0 0 0 0 A0A8C0TF17 A0A8C0TF17_CANLF Laminin subunit alpha 5 LAMA5 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] AYTALKFYLQSPEQEPG;DLRRGFEAFPELYWQAPP;GSSCQPCDCSGN;GVADGDCD;GVRHETAQ;HGYPSCRPCDCHEAGSMPSV;LAQASRLLDSTEASLGRAQ;LCMCPANYRGDSCQEC;LGEAGHAVLSVDEDI;LTGRCYCRPNFTGERCD;LVSSSGIIFFMQHQD;PGAPPEGPQP;PPVRPQLVDMEGWTL;PYSALCRATALD;QRGFGEPFVLNPGTWALVVEAEGVL;RRCNCESDFTDGTCEDLTGRCYCR;RRCQCQGGHCDVHTGRCTCPP;SCNCHGHAHDCFYDPEVD;SPHACRRCN;TGACRCRPNTQGLT;VEHNSTLELADSYYLGGVPPDQL;VEKQMLHETKGD;VGCVLRGGRTQCLCK;VGSYPSNFTPP;VLLRADDGAGEFSTWV;VQAMLAMDTDE 26 11 0.98411 -0.25703 0 9.16239 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TF19 A0A8C0TF19_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] AMERHGVDHRVISDSSKE;DIRLVTNRAGK;KAEQRKRAREKKALKKKKKT;MGLFGKSAPVDVDP;VISDSSKELEELRS 5 7.4 0.99424 -0.055831 12.1114 12.4579 0 6.94626 0 9.42568 0 0 0 0 12.3022 0 12.295 0 0 A0A8C0TF22 A0A8C0TF22_CANLF KN motif and ankyrin repeat domains 3 KANK3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] CSLWEYESSSSEDD;PGAQGRCELSP;PGAWTSSESLASDDGG;SRRGEGALEVPDAA;YESSSSEDDSDSDSEDGAA 5 8 0.99055 -0.26822 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1653 0 A0A8C0TF32 A0A8C0TF32_CANLF DNA-dependent protein kinase catalytic subunit Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; regulation of primary metabolic process [GO:0080090]; telomere maintenance [GO:0000723] nucleolus [GO:0005730] DNA-dependent protein kinase activity [GO:0004677] AAKQYNEALNKEE;EGGGGSCD;EKKHVSLNKVKKRRRPRGFPPSA;ETIDVLKSRF;FIEMKPVIYL;HVSLNKVKKRR;IPCWQFIG;LASGLLELAFAFGGLCEHL;LATPVGVPKDEVL;LLELAFAFGGLCEHLVDLL;LLVFVRKSL;LVVSENNGGEGIH;NENPPDLNKMWSEPFYQETYLPYMI;SECEFQEYTIDSDWR;VLCRAEEITN;VYRMFKRDDLLSNVTRQAFVD 16 5 0.98834 -0.4749 0 0 0 0 0 0 7.96058 0 0 0 0 0 0 0 0 A0A8C0TF33 A0A8C0TF33_CANLF Phosphatidylinositol-4-phosphate 3-kinase PIK3C2A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol-mediated signaling [GO:0048015] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; phosphatidylinositol binding [GO:0035091] DDLNQVDVGSYVLK;GLARSADAGPFSPTPG;IFPIQISQLP;IFPIQISQLPL;LHRDSSLGFADQEVRSIAVTWIE;LSVSYRNGTLFIMVM;MERVQSFFL;PIQISQLPL;SFRQDGRIKEVSVF;SLDQLTAAIYDLL 10 7.1 1.0032 -1.7043 12.4623 12.3029 12.3561 0 0 9.30389 9.77329 9.82283 0 13.7464 0 0 9.76731 0 0 A0A8C0TF34 A0A8C0TF34_CANLF Lymphoid enhancer binding factor 1 LEF1 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070] beta-catenin-TCF complex [GO:1990907]; membrane [GO:0016020] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AINQILGRRGKKKKRKREKLQ;AVSTTGMMMMMMMMMMMM;GAGGGGGG;GGGGGGGD;GVGQITPPLGW;MMMMMMMMMIAFVWLFV;SVDTSFHPAVSTTGMMMMMMMMMMM;TTGMMMMMMMMMM;VSTTGMMMMMMMMMMMMIAFVWLF 9 17.7 1.0019 -0.66162 10.7463 11.6375 0 0 0 0 8.74742 0 0 0 0 0 0 4.80792 0 A0A8C0TF37 A0A8C0TF37_CANLF CBM21 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHRLHLQPLEL;NSDLCCSSQDLEFTLQ;PAPSGCDP 3 7.5 1.0027 -1.0047 8.7451 0 0 0 0 7.45442 0 0 6.90183 0 0 0 0 0 0 A0A8C0TF40 A0A8C0TF40_CANLF Transient receptor ion channel domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) single strand break repair [GO:0000012] membrane [GO:0016020]; nucleus [GO:0005634] calcium channel activity [GO:0005262]; damaged DNA binding [GO:0003684] CCKSKKLDYPP;GAACQAPRHEGPVTD;GSGPGGPL;KSRLGRLLKIPVLKFL;LSAARRVPPASV 5 5.4 1.0027 -1.1945 0 0 0 7.65256 2.91073 7.78842 0 0 6.21261 9.5713 8.05572 11.0626 0 0 8.77926 A0A8C0TF66 A0A8C0TF66_CANLF RING-type domain-containing protein RNF128 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PETGNQTIQMANFG;SMNAYVTVTYYNETSNYTTTE 2 9.6 0.99169 -0.20899 0 0 0 0 0 0 0 7.04188 0 0 9.09985 0 0 0 0 A0A8C0TF75 A0A8C0TF75_CANLF Protein kinase C-binding protein NELL2 (NEL-like protein 2) Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AALNVTQGLAVSASI;DENALCFNTVGGHNCVCKP;FTGPSCETD;GWYHCECRDGYHDNGMF 4 7.8 0.99274 -0.17531 0 0 0 0 0 0 0 0 0 0 0 9.46593 0 0 0 A0A8C0TF99 A0A8C0TF99_CANLF Anion exchange protein SLC4A10 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] DQVTVLPPGEWDPS;EEEQSMLAMEDEGT;FTKRELSWLDDLMPESKK;IVSDFAVFLTI;LEEIADMVLDQ 5 5.9 0.99196 -0.19417 8.67218 0 0 0 0 0 13.8252 0 0 0 0 0 0 0 0 A0A8C0TFB3 A0A8C0TFB3_CANLF Peptidase M12B domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] KRLMSSILTSID;KVRQFKAKDQTRF;SPAPFPAPPAASPDG;YYSTSSHGNWGSWGSWGQCS 4 6.4 1.0026 -0.77336 0 10.9667 0 0 0 0 0 8.55884 12.7816 0 0 0 0 17.5739 0 A0A8C0TFC5 A0A8C0TFC5_CANLF Stabilin 1 STAB1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540] AIDECELDARGGCH;CHEGFHGTACEMCE;EAEAACAAQGAVLASLPQLSA;HGGCSQHANCSQVGT;HRPLTMLWPTDA;RKNRSECWDAYCYREQDVAC;SGECRCHEGFHGTACEMC;SPIDPCRAGNGGCH;TDAALQALPPD;VGDGLQCVEEPEPPV 10 5.4 0.99339 -0.14988 0 8.73312 10.0966 0 5.45408 10.2528 0 8.46181 0 0 0 0 0 0 8.01992 A0A8C0TFD2 A0A8C0TFD2_CANLF "2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)" OGDH Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleus [GO:0005634] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [GO:0016624]; thiamine pyrophosphate binding [GO:0030976]" ALVLWEAQFGDF;KICEEAFTRSK;LSDLPSYTTHGTVHVVVNN;LVEDHLAVQ;MCNDDPDVLPNLEEANFD;QEEHKNQGYYDYV;SAMARAQPLVEAQ;TVSSNVGF 8 10.1 1.0032 -2.2815 0 8.05311 8.13709 0 11.4806 0 0 0 6.51223 0 0 0 0 12.9177 8.80616 A0A8C0TFF7 A0A8C0TFF7_CANLF PA domain-containing protein RNF128 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CLYKSLFPMRHQ;TVPGDWGRTVQ 2 5.7 0.99095 -0.5145 0 0 0 0 9.78918 0 0 0 0 0 0 9.25486 0 0 0 A0A8C0TFF8 A0A8C0TFF8_CANLF Zinc finger and BTB domain containing 8A ZBTB8A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]" AEQHLMSPSDGD;EISSHQSHLLQQLNEQ;FVYSGKLSLTGQNVIEVMS;VEIVEDGSADL 4 13.2 0.9931 -0.18767 0 9.84016 0 0 9.68478 11.7714 0 0 0 0 0 0 0 0 0 A0A8C0TFH9 A0A8C0TFH9_CANLF Signal peptide peptidase like 3 SPPL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane protein proteolysis [GO:0033619]; signal peptide processing [GO:0006465] Golgi-associated vesicle membrane [GO:0030660] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" ALLYLVPFTL 1 2.9 0.99957 -0.61146 0 0 0 7.5089 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TFI2 A0A8C0TFI2_CANLF LEM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020]; nucleus [GO:0005634]; organelle envelope [GO:0031967] nucleic acid binding [GO:0003676] GGGGGGGG;KEEEETRQMYDMVIKIIDV;QQGGGADA;RPVYLKKLKKL 4 5.4 0.94903 0.049568 0 0 8.83444 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TFI9 A0A8C0TFI9_CANLF GATA-type domain-containing protein GATAD2A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565] EAKLVLLKKLRQ 1 2 0.95381 0.05044 0 0 0 0 0 0 0 9.103 0 0 0 0 0 0 0 A0A8C0TFJ5 A0A8C0TFJ5_CANLF histone acetyltransferase (EC 2.3.1.48) Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; nucleus [GO:0005634] histone H3K9 acetyltransferase activity [GO:0043992] AAAAAGGSGACGPATAV;LTHIDFFCEGVN;PGGGGAGA;VFGRTLLRSVFTVMRRQLLEQ;VIIKKQKEIIKKLIERK;VLDVEYLFTCVH 6 9.3 0.98988 -0.31446 13.9104 5.2317 6.00529 0 0 3.71633 0 6.17566 0 0 0 12.5835 6.76739 0 0 A0A8C0TFK3 A0A8C0TFK3_CANLF O-acyltransferase SOAT2 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] cholesterol O-acyltransferase activity [GO:0034736] ELLDRAMWEAVRSYPPQGGP;PSPGKRKIFIIRK;TVGLCALP 3 7.8 0.99426 -0.020491 0 0 0 0 0 8.25338 0 0 0 7.9273 5.35632 8.17413 0 0 0 A0A8C0TFK6 A0A8C0TFK6_CANLF WDFY family member 4 WDFY4 Canis lupus familiaris (Dog) (Canis familiaris) AWQHYLASEKKSLSN;CSWKEPTFCVLR;CWPPWMSLSEHMH;DAGSDPQGNV;EDAGSDPQGNV;EKEFQPLDVMEPEDDPEPSAGR;GLLGLLLAQLRKRAKILRK;GVFRHILCNFELWMNTADNLE;HLMQHIRGYQIMAF;HPSTTVLGLKLL;HQHFYICEN;IQALPGPFLSMDPSSFVDVY;LVIATTCLREHSCCSWK;PLIRSTILGF;SGGNVPLLRDSKE;SSFVDVYGYISTP;VIMHPGIL 17 7 0.94277 0.059626 0 0 0 0 0 0 0 0 6.79585 0 0 0 0 0 0 A0A8C0TFR6 A0A8C0TFR6_CANLF Activation induced cytidine deaminase AICDA Canis lupus familiaris (Dog) (Canis familiaris) cytidine to uridine editing [GO:0016554]; defense response to virus [GO:0051607]; DNA cytosine deamination [GO:0070383]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869] nucleus [GO:0005634]; P-body [GO:0000932] cytidine deaminase activity [GO:0004126]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GVQIAIMTFKD;LCMSVWVSLFP;LDFGHLRNKSGCHVEL;LSRQLRRILLVRGF;YHFKNVRWAKG 5 17 0.98933 -0.31064 8.92893 0 9.13743 5.48649 0 0 10.2227 0 0 0 0 0 0 4.30064 0 A0A8C0TFT6 A0A8C0TFT6_CANLF Glycosyltransferase 1 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] EDINQREKNQ;EFVQLAKRLVIIFSL;GGGGDGGG 3 5.8 0.95209 0.053887 0 0 0 0 0 0 0 3.41954 0 0 0 0 0 0 0 A0A8C0TFT8 A0A8C0TFT8_CANLF Rab geranylgeranyltransferase subunit beta Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein prenyltransferase activity [GO:0008318] SKKDDYEYCMP 1 6.5 0.9836 -0.2525 0 0 0 0 0 0 0 0 0 0 12.3436 0 0 0 0 A0A8C0TFU4 A0A8C0TFU4_CANLF Olfactory receptor OR7A61 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVSSDPHLHTPMYFFLTNLSFVDI;ELELQPLVFGLFLSMYL;GNYTGISEFYLMGFSE 3 16.9 0.86967 0.13676 0 0 0 0 0 0 9.29923 0 0 0 5.2257 0 0 0 0 A0A8C0TFV2 A0A8C0TFV2_CANLF Transmembrane protein 181 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] toxic substance binding [GO:0015643] APRVSPRRPE;ELREDLTPFRDDRYYRL 2 4.5 0.99569 -0.56523 0 0 0 0 7.77063 0 0 9.53978 0 0 0 0 0 0 0 A0A8C0TFW5 A0A8C0TFW5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QLMVPVMAT 1 2.8 0.98728 -0.22922 0 0 9.53165 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TFY5 A0A8C0TFY5_CANLF Pleckstrin homology domain containing A5 PLEKHA5 Canis lupus familiaris (Dog) (Canis familiaris) FSKEFKKTEDIF;QSPSVLRDNP;RNQMQEQLDRLGEVQTESAGIQRAQ;SLQGKTMKENEPI;VLIKPEVQ;VMARYPEGYR;YKSEPELTTV;YYRDEKEEGILG 8 9.1 1.0032 -2.3253 0 0 0 9.74673 10.6137 8.56769 11.1539 0 7.447 8.75826 0 8.40267 0 0 0 A0A8C0TFY7 A0A8C0TFY7_CANLF PID domain-containing protein CCM2 Canis lupus familiaris (Dog) (Canis familiaris) LALDTLACAITSSMSRSS 1 3.6 0.97416 0.048313 0 0 0 0 0 0 5.50351 0 0 0 0 0 0 0 0 A0A8C0TFY9 A0A8C0TFY9_CANLF Y-box-binding protein 1 (Y-box transcription factor) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676] ATKVLGTVKWFSVRNRY;PQCQYRGNLNYHHRRPENPKPQDGK 2 14.1 0.98285 -0.25162 0 0 0 0 0 0 0 0 0 8.03782 0 0 0 0 11.1655 A0A8C0TG52 A0A8C0TG52_CANLF WDFY family member 4 WDFY4 Canis lupus familiaris (Dog) (Canis familiaris) AWQHYLASEKKSLSN;CSWKEPTFCVLR;DAGSDPQGNV;EDAGSDPQGNV;EKEFQPLDVMEPEDDPEPSAGR;GLLGLLLAQLRKRAKILRK;GVFRHILCNFELWMNTADNLE;HLMQHIRGYQIMAF;HPSTTVLGLKLL;HQHFYICEN;IQALPGPFLSMDPSSFVDVY;KPSKTSPAVTALAV;LVIATTCLREHSCCSWK;PLIRSTILGF;SGGNVPLLRDSKE;SSFVDVYGYISTP;VIMHPGIL 17 7 1.0032 -2.1063 9.42183 11.581 9.61191 0 9.17333 0 10.919 0 13.5982 0 9.8858 9.40669 9.47871 11.371 5.06039 A0A8C0TG56 A0A8C0TG56_CANLF Helicase ATP-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] VGVERRKVYNPR 1 1.7 0.94652 0.05044 6.79259 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TG64 A0A8C0TG64_CANLF TBC1 domain family member 10A TBC1D10A Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of proteolysis [GO:0045862]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; plasma membrane [GO:0005886] PDZ domain binding [GO:0030165] AAGAAGMAKSRGENGPRAPAAEGSL;EANGFAERR;WLDVIERDLHRQFPFHEMFVSRGG 3 10.5 1.0038 -1.0541 9.32204 0 0 0 8.97854 0 0 9.63361 0 0 0 0 0 0 0 A0A8C0TG74 A0A8C0TG74_CANLF ILEI/PANDER domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; membrane [GO:0016020] carbohydrate binding [GO:0030246] GVQNKSPFEQ;IVAVGLTWIVVSILLGGPG;PPRPGQRSTSQACGVTAGPSP;SPDNSATP 4 9.1 1.0016 -1.2518 0 0 0 0 0 0 0 3.95801 10.5063 6.61338 0 0 0 0 0 A0A8C0TG76 A0A8C0TG76_CANLF Myosin IF MYO1F Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ADSVTKYDRRFKPIKRDLILTPK;AEQEEYVQEGIRW;DTYAPRHRPRAARGTEP;ETKKPRDWEESRVKHQVE;KQMPYFTDRE;LLAFPAYLLGI;NSWSSGFVIHHYAGKVSY;RCTPHYIRCIKPNETKKPRDWEESR 8 11.7 1.0024 -0.72438 0 11.8986 12.1163 0 5.49908 0 0 11.8827 0 6.50449 9.26421 0 0 0 5.79121 A0A8C0TG81 A0A8C0TG81_CANLF DNA helicase B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; DNA helicase activity [GO:0003678] ESEVERACEDFE;FLPILLPRHFKWL;LSPTHHPFFGPQP 3 3.1 0.85844 0.16971 0 5.12635 0 0 0 0 0 0 8.69735 0 0 0 0 9.1342 5.84099 A0A8C0TG82 A0A8C0TG82_CANLF Transcription elongation factor A protein-like 4 Canis lupus familiaris (Dog) (Canis familiaris) EVKKTRQKL 1 3.7 1.0042 -0.80421 0 8.66359 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TG91 A0A8C0TG91_CANLF Developmental pluripotency associated 3 DPPA3 Canis lupus familiaris (Dog) (Canis familiaris) methylated histone binding [GO:0035064] VQTMSEVLVKNLSKL;YACVYRSLWSYFPHHLQIKSSFL 2 17.1 0.99371 -0.28126 0 0 0 9.86912 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TGA3 A0A8C0TGA3_CANLF UTP14A small subunit processome component UTP14A Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; small-subunit processome [GO:0032040] LKKEKAKKALKDFEKLQ;YEARARREKKIKSKKYHKVLKK 2 5 0.93775 0.092926 0 0 0 0 0 0 0 0 0 4.32553 0 0 0 0 3.61377 A0A8C0TGB6 A0A8C0TGB6_CANLF Glycosyltransferase 1 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] AAFHLLRGILCTGA;EDINQREKNQ;GGGGDGGG 3 4.9 0.93703 0.060949 0 0 0 0 0 0 0 0 0 0 6.22425 0 0 0 0 A0A8C0TGB9 A0A8C0TGB9_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] EDGGGGGG;GGGGGGGA;GLDSRYSEAW;KALRAKTNTYIK;QTPQPPTAPKGASDAKL;VYYSVAETSPPLWAG 6 12.4 0.99074 -0.51086 0 0 0 0 0 0 7.13965 0 6.49961 0 0 8.34287 0 0 0 A0A8C0TGE2 A0A8C0TGE2_CANLF Immunoglobulin subtype domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] CCPQYCCCYIRCPCCPA;CWCQCCPQYCCCYIRCP;EVRIVAQRRGQNE;GVCWCQCCPQYC;GVCWCQCCPQYCC;GVCWCQCCPQYCCC;GVCWCQCCPQYCCCYIRC;IFIILGALLLLLLI;LTVIFIILGALLLLLLI;PRGDAQRPRRRRHRSY;PSGLSSCSSEEEG;VHRELQGREPKRL;WCQCCPQYCCCYIRCPCC 13 18.8 0.93742 0.059581 0 0 0 0 0 0 0 0 5.16756 0 0 0 0 0 0 A0A8C0TGF2 A0A8C0TGF2_CANLF "60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60)" Canis lupus familiaris (Dog) (Canis familiaris) protein refolding [GO:0042026] chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] EAGDGTTTPTV;EEAGDGTT 2 5.1 0.984 -0.24465 0 9.55553 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TGF3 A0A8C0TGF3_CANLF CCDC81 HU domain-containing protein CCDC81 Canis lupus familiaris (Dog) (Canis familiaris) ASDKLFLLDQCEK;LVEQKQDLQMLRRTQ;YSEERKRREIEDERLIQQYQMLKDQ 3 9.4 0.99239 -0.18033 0 0 0 0 0 6.06389 0 9.55922 0 0 0 0 0 0 0 A0A8C0TGH3 A0A8C0TGH3_CANLF Caspase 10 CASP10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] CD95 death-inducing signaling complex [GO:0031265]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625] HVYKNVTKGHLDEVLQEFK;KREKASEVVTPPV 2 6.7 0.9052 0.12305 6.39997 0 0 0 9.09392 0 0 0 0 0 0 0 0 0 0 A0A8C0TGK3 A0A8C0TGK3_CANLF Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) ADRB1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart contraction [GO:0045823] plasma membrane [GO:0005886] beta1-adrenergic receptor activity [GO:0004940] AASDDDDDDDD;AASDDDDDDDDD;AASDDDDDDDDDEDD;DDDDDDDDDEDDAGAGA;DDDDDDDDDEDDAGAGAGAGA;DDDDDDDDEDDAGAGA;DDDDDDDDEDDAGAGAGAG;DEDDAGAGAGAGAGAGAA;HWWRAGGDEARRCYNDPKCCD;IVLLIVAGNVLVIAAIAKTPRLQT;LMHWWRAGGDE;MHWWRAGGDEARRCYNDPKC;PGAASDDDDDDDDDEDD;PPPSPGAASDDDDDDDDDEDDAG;PSPGAASDDDDDDDDDEDDAGA;SDDDDDDD;SDDDDDDDD;SDDDDDDDDDEDDAG 18 16.9 0.93743 0.075075 4.82985 4.8039 5.94462 0 0 5.56636 8.58635 7.10612 4.71567 0 0 0 7.98231 6.83188 6.43956 A0A8C0TGL3 A0A8C0TGL3_CANLF GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] EGKEVDTTLFAEFQA;GLPGSPGTGASL;KSTSSALCPAMCPTA;SSSVDQHRLS 4 10.2 0.98245 -0.24828 0 0 0 0 0 0 9.34154 0 11.734 0 0 0 0 0 0 A0A8C0TGL7 A0A8C0TGL7_CANLF RAD54 homolog B RAD54B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] EEPDSLVKYFSVVWCKAS;IVDSFNSKYSSD;KHFSGDHLNLTDPFLERIR;MAYKLKELEKIEEGH;QWTFNKKGFPV;WKHFSGDHLNLTDPFLE 6 8.4 0.68401 0.29696 0 0 0 0 0 7.15613 0 0 8.54423 0 0 0 0 10.5241 8.24303 A0A8C0TGN2 A0A8C0TGN2_CANLF Syndecan Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; dendrite morphogenesis [GO:0048813] cell surface [GO:0009986]; membrane [GO:0016020] EAGGGRRRREPQSALVRASPQS;EDHPKADERAELTSDKDMYLD;FLPSDQEQML;GVIGFLFAIFLILLLVYRMRKK;GVIGFLFAIFLILLLVYRMRKKD;SERKVDPSDE;YPIDDDDYASASGSGADEDGES 7 20.5 1.0023 -0.98684 0 0 10.3046 6.60903 0 0 8.59197 5.61129 0 0 0 0 9.862 0 4.8127 A0A8C0TGP9 A0A8C0TGP9_CANLF Immunoglobulin binding protein 1 IGBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] EDQEQKEDEDDEQM;QVNPSKRLDHL;SKRLDHLEWAREHFLNYLTQCQY 3 11.4 0.99323 -0.16 0 0 10.1718 0 0 0 0 4.12391 0 0 0 0 0 0 0 A0A8C0TGU9 A0A8C0TGU9_CANLF C2H2-type domain-containing protein SP1 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EACTCPYCKDSEG;EPDCESPHCD;SSSGGGGG;SSSSGGGG;TCSCGTDFCNANYS;VGGNNGGN 6 7.1 1.0033 -1.3814 0 0 0 0 0 8.67902 0 0 0 0 0 0 7.91767 0 0 A0A8C0TGY7 A0A8C0TGY7_CANLF Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) SPTSSB Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029] endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059] serine C-palmitoyltransferase activity [GO:0004758] MDFKRVKDYF 1 13.2 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.7933 A0A8C0TH58 A0A8C0TH58_CANLF RASGRP2 RASGRP2 Canis lupus familiaris (Dog) (Canis familiaris) EGLQFAAGENVPPGQVLDLS 1 32.3 0.95409 0.049371 0 0 0 0 0 0 0 0 0 0 9.13648 0 0 0 0 A0A8C0TH66 A0A8C0TH66_CANLF RRM domain-containing protein ENOX2 Canis lupus familiaris (Dog) (Canis familiaris) ultradian rhythm [GO:0007624] external side of plasma membrane [GO:0009897] oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723] ESVSQAEALKEENDS;IIHCKSCTLFPPNP;KAWDHFTKAQ;LDAYRNEVELLKQEQGK;LVNEKAAHEKDMEEAKEK;WIERGEVNRRSANNFYSMIQSANS 6 18.2 0.98655 -0.32837 0 0 9.39053 0 0 9.55959 9.6821 0 9.47397 0 0 0 0 0 0 A0A8C0TH92 A0A8C0TH92_CANLF TLC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] membrane [GO:0016020] sphingosine N-acyltransferase activity [GO:0050291] AEAQSPKPGK;RGPSPCRATRS 2 4.3 1.0021 -0.90456 0 0 0 0 0 0 0 0 0 0 0 0 6.48304 0 0 A0A8C0THA2 A0A8C0THA2_CANLF "2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)" OGDH Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleus [GO:0005634] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [GO:0016624]; thiamine pyrophosphate binding [GO:0030976]" ALVLWEAQFGDF;KICEEAFTRSK;LSDLPSYTTHGTVHVVVNN;MCNDDPDVLPNLEEANFD;QEEHKNQGYYDYV;YAWLENPKSVHKGSTAWT 6 10.4 0.98519 -0.24109 0 0 0 0 0 0 0 0 0 0 0 0 0 13.6306 0 A0A8C0THA5 A0A8C0THA5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MGISPLSCILLS;VTFTGNLLIIL 2 7.4 0.98956 -0.52959 0 0 0 0 0 0 0 10.3229 0 0 9.33809 0 9.90382 0 8.75989 A0A8C0THA7 A0A8C0THA7_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; small GTPase-mediated signal transduction [GO:0007264] cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] FSIANPNSLH;SLHHVKTMWY;SRSCGRTAPLSL;YDLFLMDLSEG 4 5.2 1.0024 -0.71504 13.7903 0 0 0 0 0 4.02901 0 0 0 10.4665 0 0 0 0 A0A8C0THE3 A0A8C0THE3_CANLF DMAP1-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADACTPPDTSSASEDE;GGGGGGSG;IDIETSVS;IELIAAFYGCL;IETSVSRIHRSIAECAVFTW;PQSLLLSESGKILPG;TDEIGEICVSSR;VRLVERGA;VTTTTSSS 9 5.8 0.99913 -3.119 0 13.1171 9.36918 0 0 0 9.80645 9.3932 0 7.20369 0 0 8.17108 10.6749 0 A0A8C0THH3 A0A8C0THH3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) EATITLIP 1 1 0.98972 -0.26592 0 0 0 6.59285 0 0 0 0 0 0 0 0 0 0 0 A0A8C0THH9 A0A8C0THH9_CANLF Cystatin LXN-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metalloendopeptidase inhibitor activity [GO:0008191] AGACWPGP;PCRIHLVWYPGK;RREDFLLYKRAKRL 3 7.4 1.0036 -1.1044 0 0 9.02389 0 8.13525 0 0 0 0 0 0 9.803 0 0 0 A0A8C0THI0 A0A8C0THI0_CANLF DUF4585 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EPSTEDLRTLSPRGLV;HGETGEEKPCLEDWEQRP;KGRKESLPDASEEK;LCISEDTS;LTLSPDISRQVF;VGLPEKPEPPAQLE 6 6 0.99411 -0.5619 0 0 0 0 10.6547 0 10.5629 0 0 0 0 0 11.3062 8.55071 0 A0A8C0THI3 A0A8C0THI3_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GGGGGGGD;GGGGGGGG;GTARAIQYLHNTEP;RTYAIKLFKQ;SCSCEFSWNECE;SCSCEFSWNECEQ;SVASSSSKH 7 8.1 1.0019 -0.96769 8.67634 0 8.41945 0 0 9.14062 0 0 0 0 0 0 0 6.63071 0 A0A8C0THK8 A0A8C0THK8_CANLF Protein kinase C-binding protein NELL2 (NEL-like protein 2) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] DENALCFNTVGGHNCVCKP;FTGPSCETD;GWYHCECRDGYHDNGMF;VCLSRHAPEIE 4 6.5 0.98391 0.035491 0 0 0 0 10.058 0 0 0 0 0 0 0 0 0 0 A0A8C0THM4 A0A8C0THM4_CANLF Integrator complex subunit 13 INTS13 Canis lupus familiaris (Dog) (Canis familiaris) centrosome localization [GO:0051642]; regulation of mitotic cell cycle [GO:0007346] cytoplasm [GO:0005737]; integrator complex [GO:0032039] ELETLVRAHIN;ETIHEHNKLAANSDHLMQI;FVVDHCPYMAESCRQHVEFDMLV;HHKDAHVDFLKSGDTHI;NLQELMAALAAVGPPN;PKRDEQYRIMWNEL 6 15.1 0.98834 -0.34502 0 12.892 0 9.71855 0 0 0 6.50806 8.42924 0 0 0 0 0 9.46103 A0A8C0THN3 A0A8C0THN3_CANLF RRM domain-containing protein PPRC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] AAIESGHKLRQADEQPFDLCFGGR;AWARAWAAALEKPSSGNLES;ESISSLSELVRAMHPYCLPNL;GSVSGGEQVLLH;IPDSELLVSPREGSSL;LAPSTLLSPEASPCRND;LSEYRRRRQQRQ;LVSGTPGTYAVPPTCN;RRRQQRQAE;SEAKKECPPPAPADSLAVGNSG 10 9.8 1.0033 -1.5591 0 5.12582 8.61489 8.2529 10.428 8.17582 0 9.4402 0 8.36763 0 0 0 7.87492 11.225 A0A8C0THP6 A0A8C0THP6_CANLF Cysteine sulfinic acid decarboxylase Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] LGAFDPLEAIADVCQRHG;SEQILARCRAV;TPYSPYSPTL 3 7.3 0.9995 -0.61146 0 0 0 0 0 0 0 8.08433 0 0 0 0 0 0 0 A0A8C0THQ5 A0A8C0THQ5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PCHCPCLCSRSRLCPQ 1 8.3 0.96431 0.049233 0 0 0 0 0 0 0 0 11.0299 0 0 0 0 0 0 A0A8C0THR3 A0A8C0THR3_CANLF Rho-GAP domain-containing protein ARHGAP36 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DEEDEDDDDDNDDT;EEDEDDDDDNDDT;EEFDQGLDVVL;ELDEEDEDDDDDN;GIPELDEEDEDDDDDNDDTLIFDD;IPELDEEDEDDDDDNDDT;LDEEDEDDDDDNDD;LDEEDEDDDDDNDDT 8 3.5 0.88341 0.13073 0 7.76553 8.05875 5.13455 0 0 0 7.48752 0 6.68468 0 7.88264 0 6.79753 0 A0A8C0THR4 A0A8C0THR4_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FVWPTIPVAPEMT;YSKSSLFFLSLSPSVLTE 2 3.1 0.97201 0.048313 0 9.96336 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0THS0 A0A8C0THS0_CANLF Rho GTPase activating protein 39 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856] DGQLLHYRTS;KPTAFPPSPKQGPASPY;LLKLWYRELEEPLIPHEFYEQCIAH;NWASKHFNTHTQ;PCPLRGPMEGAEL;PVVRAFSEDEALAQQESKH;RALLERNSKKKPKLRKKPKP 7 10.7 0.97259 0.048206 0 0 0 0 0 0 0 0 6.47645 0 0 0 0 0 0 A0A8C0THS2 A0A8C0THS2_CANLF Phosphatidylethanolamine binding protein 4 Canis lupus familiaris (Dog) (Canis familiaris) DEGDMCLYEALSD;GGLFICGC;SPPAQTGFH 3 8.7 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 3.12441 0 0 0 0 0 A0A8C0THS3 A0A8C0THS3_CANLF Integrin beta ITGB7 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] plasma membrane [GO:0005886] APPRDPAAEPPPAAGEPQRL;GRMGEDGEYGRMGGGC;GSACECSMDTDSC;HCSDGQGLLQCGVC;MVALLTVLVLLLALRRG;RDPDLSLLGSC 6 10.1 0.94323 0.088356 12.9571 0 0 7.8996 5.34827 0 0 0 0 0 3.31351 7.93345 6.53844 0 0 A0A8C0THS7 A0A8C0THS7_CANLF GH84 domain-containing protein OGA Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein metabolic process [GO:0009100] beta-N-acetylglucosaminidase activity [GO:0016231] DYDQKRLFLGPYK;GAAVAGAAGGARRFLCGVVEGFY;LKLSCQPMLSLDDFQL;QEPWAFRGGLA 4 6.2 0.94085 0.059617 0 5.08644 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0THW2 A0A8C0THW2_CANLF Glypican-1 GPC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DVPQAEISG;GTGGPRGGVRGAGSTAGP;ITDKFWGPSGAESVIGGVHLWLAE;LYYRGANLHLEDT;MLCSEKMAMSSASDDRCW;PDYCRNVLKGCLANQ;TSAASCPQPCASL;YCRNVLKGCLANQADLDAEWRNL 8 18.3 0.99163 -0.5451 0 8.81301 0 9.99944 3.62936 0 8.93091 9.54396 10.4479 9.61925 0 11.6239 0 0 0 A0A8C0THW5 A0A8C0THW5_CANLF Exostosin like glycosyltransferase 3 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] FYRSWNSAPGPFHLFP;ITRKPPIKVRVPVLI;LAMRRQGRFLWETYFS;PAAPIREEAAAE;VIRGCRLHNCFDYSRC;VLMNSLERLNGLPYLNK 6 10.6 0.95094 0.053874 0 7.74813 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0THX2 A0A8C0THX2_CANLF C2H2-type domain-containing protein ZNF280C Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] MKHHLELEKQNSESWE;NSKMAELFMECE;SDLGESPFLHDWPP;VTPKKPKTNESVSEI 4 6.9 0.86063 0.16409 8.13699 0 0 0 0 8.67916 0 0 0 0 0 0 10.2551 0 0 A0A8C0THX4 A0A8C0THX4_CANLF Rho GTPase activating protein 39 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856] DGQLLHYRTS;EGYIYRHMDPVNDTKGKARGTRPLA;KPTAFPPSPKQGPASPY;LLKLWYRELEEPLIPHEFYEQCIAH;NWASKHFNTHTQ;PCPLRGPMEGAEL;PVVRAFSEDEALAQQESKH 7 11.4 1.0033 -1.3824 0 0 0 8.08226 0 10.033 0 0 10.7144 8.95257 0 0 9.27461 0 0 A0A8C0THY0 A0A8C0THY0_CANLF ITPR-interacting domain-containing protein ITPRID2 Canis lupus familiaris (Dog) (Canis familiaris) signaling receptor binding [GO:0005102] AFSWPSLALLSFLS;GGVGGGGG;LSAQMQRMEV;SGLLAAVS 4 2.3 0.98808 -0.34608 0 0 0 0 0 9.53195 0 0 0 0 12.0897 0 0 0 0 A0A8C0THY5 A0A8C0THY5_CANLF Glycosyltransferase 1 domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] DLWEENLLKGTTAVL;EDINQREKNQ;GGGGDGGG 3 6.7 0.98662 -0.42503 0 0 0 0 0 0 11.6337 0 0 0 0 0 9.3122 0 0 A0A8C0THZ8 A0A8C0THZ8_CANLF Splicing factor 1 SF1 Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]" spliceosomal complex [GO:0005681] mRNA binding [GO:0003729]; pre-mRNA branch point binding [GO:0045131]; zinc ion binding [GO:0008270] AAFPFAAL;EDQNDLRKMQLREL;PPPSSSMA;VTANTMENVKKAVEQIR 4 7 1.0033 -1.5661 0 0 0 9.1717 0 0 0 9.13391 0 0 0 9.84205 0 0 0 A0A8C0TI01 A0A8C0TI01_CANLF Methyl-CpG binding domain protein 5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DRQMRPPKPK;GVLNSASANTAN;IVTTAAGNPLQSQLPIGSDFP;LSQSGMALGNSLHPNP;LSSNSTPGCGGSNTALPC;NPLQSQLPIGSDFP;NVNAALAFLSGDMD;PAIQVPVG;PLSPPSVMLHGSPVQSSC;VGWQRRVDQ 10 7.2 0.99898 -3.0406 0 0 0 0 0 0 10.3238 14.1611 0 0 9.65197 0 9.5112 0 10.1673 A0A8C0TI07 A0A8C0TI07_CANLF Peptidase metallopeptidase domain-containing protein MMP21 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DTAFYDRRKQLIYFFKESLVFAFD;FKESLVFAFDVNRNQVL;FRMWSEVMPLHFRE;IMQPNYVPQEPV;LKVRGRQRLAC;TWRRDERYFFKGNQYWRYDSDKD;YFFRNSWYWLYENRNNRTRYGDPI;YYSYAHNSL 8 19 0.99632 -0.58239 7.42265 10.62 0 0 0 0 0 7.28956 7.6844 0 0 0 0 0 11.0907 A0A8C0TI17 A0A8C0TI17_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] HTLCLKMVVGAYHDF 1 5 0.95225 0.053899 0 0 0 0 0 0 0 7.77893 0 0 0 0 0 0 0 A0A8C0TI31 A0A8C0TI31_CANLF StAR related lipid transfer domain containing 8 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] lipid binding [GO:0008289] IAVSLSPEPEPMDLPTPCHVPSL;RMWRSDLPRGGC 2 3.6 0.99146 -0.20596 0 0 0 0 0 0 0 0 0 0 0 9.51066 0 0 0 A0A8C0TI35 A0A8C0TI35_CANLF t-SNARE coiled-coil homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] KYHSKARRKMMFIIICV 1 5.9 0.97761 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 8.59036 0 0 A0A8C0TI47 A0A8C0TI47_CANLF Cation/H+ exchanger domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sodium:proton antiporter activity [GO:0015385] DLNYTMSNFTLLTK;IHKIESTEINKLIMAKKK;IVLRLLVFLLLSPLLS;LDFQPVIKPLT;LICTVGGE;LVLYIMEALLK;SRFGHGFSWRWAFIMVWSEMKGTPN;TDEFEYVGYLVT;TKGLHDVTSTKYKS;YKAPSLIPITCYQVQGTEDFTKVMI 10 18.3 0.93343 0.060838 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.38 A0A8C0TI58 A0A8C0TI58_CANLF Ubiquitin-activating enzyme E1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634] FAT10 activating enzyme activity [GO:0019780]; ubiquitin activating enzyme activity [GO:0004839] ADIVHWLSW;DGDEDCLD;EAIYSDEF;ISNITQAN;PDTDGDEDCLDLQ 6 4.8 0.99913 -3.2175 0 0 0 4.86711 0 0 0 0 10.0837 10.5106 0 0 0 0 0 A0A8C0TI64 A0A8C0TI64_CANLF C2 calcium dependent domain containing 6 Canis lupus familiaris (Dog) (Canis familiaris) FNIFFKYNQF;HKERKLPDND;IDRLLESG;KMKYPLNKSL;RKPILSPKLRIFLE 5 3.5 0.99964 -0.61146 0 0 0 0 0 0 0 8.79279 0 0 0 0 0 0 0 A0A8C0TI73 A0A8C0TI73_CANLF Fork-head domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GQAGLSRARDPKTYR;GVAGMGPHLSPS;IYQWIMDL;LPPEAHLKPEH;SPNKMLTLSEIYQWIMDLFPF;YQWIMDLFPFYRQNQQRWQN 6 14.8 0.9957 -0.56742 0 2.94212 9.01137 0 0 11.1591 9.71799 8.98732 0 0 0 3.0084 0 0 9.73934 A0A8C0TI78 A0A8C0TI78_CANLF Sorbin and SH3 domain containing 1 SORBS1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] insulin receptor binding [GO:0005158]; signaling receptor complex adaptor activity [GO:0030159] GVHVPPPG;KAQTLKELPLQ;MHQINRAGL;PITYVDVIKRPL;PLQYHPRQPPPGDF;PPPGDFSAPPAGQKPDLPS;SEDDDSDLYSPRYS;SLSDPVSERRVGEQD;SPSPEISSELPGYLYS;TASPQFASHSKLFMPAPSSL 10 7.9 1.0017 -0.69318 0 0 10.412 0 7.80265 0 0 0 0 0 0 0 0 0 7.48607 A0A8C0TI93 A0A8C0TI93_CANLF Hexosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" FLVMWYLSLPHYNV;HYNVIERVNWMYFYEYEPIYRQD;LLTTLPSRMSL 3 21.9 0.98872 0.034772 0 0 0 0 0 0 0 0 0 0 0 0 0 6.95198 0 A0A8C0TIA0 A0A8C0TIA0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IILKLISLILLL;KIILKLISLILL;KIILKLISLILLL;LLIKPEDIVL 4 9.6 0.85977 0.16044 0 0 4.60703 0 0 0 0 4.34511 0 3.46845 0 0 0 0 3.09818 A0A8C0TIB9 A0A8C0TIB9_CANLF Pescadillo homolog PES1 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" "chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021] EEGDDGDEGGENE;GDDGDEGGENEEEEEEDA;PGVATRCGCTGELW;QLCRRLTVEFLHYV;VPREALAFV 5 9.2 1.0045 -1.044 0 0 0 7.63198 9.70984 0 10.0367 0 0 0 0 0 10.1616 0 0 A0A8C0TIC7 A0A8C0TIC7_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVIRQYNKISY;DLLDISNLPMWKP;EAKLTQVIENWTNQNLSF;FYPGVAEHKDISKL;HPGGGRNDIPQRLKRQFTVFN;IEEAYAIL;ILNTLIAQTTHDL;INHTIERILQYY;KLKNFYPGVAEH;LDPLSFLIN;LDQYFEYIQ;LINDLFPGLQLDSSTYVELQ;LKGTESGEIITLMEDSL;LKNKDDIEDIC;LTGEQGTAKTVMVKAYMK;LVPSFDFLSEKLQFYQR;PENLKIQFRT;PFRWILDMTWLNLVE;PGEAPPPSDEEGQR;RCLGKYVV;SYLSFINGYKNIYTEKVKHINEQA;TSLKFTNEPPQGI;VEHLHKLFVREK;VHVWDQETPIVLKKIQDCIFLFKEY;VLHKTRKELNLLQK;VPEQAKKLLKLESKLKA 26 7.9 0.99904 -3.2204 9.47711 6.7765 7.07959 1.99996 8.33392 7.40284 0 14.1558 0 7.54195 7.70563 10.9226 8.53916 11.2411 11.2571 A0A8C0TID2 A0A8C0TID2_CANLF Enhancer of polycomb homolog EPC2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; piccolo histone acetyltransferase complex [GO:0032777] FNLDNEQPDYDMDSED;GGITEEQFQTHQQQLVQ;GWGWPGDG;KRREKTKRELLHL;KVQECKTKV 5 7.4 1.0032 -1.5633 12.7737 0 0 5.81391 0 0 0 7.21199 6.16826 0 0 0 0 0 0 A0A8C0TIE1 A0A8C0TIE1_CANLF "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial" NDUFA10 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial matrix [GO:0005759]; mitochondrial respiratory chain complex I [GO:0005747] VIEDIEYLKYD;VLSVPEASVPVGQT 2 7 0.98962 -0.21755 8.58094 0 0 0 0 0 0 0 10.1417 0 0 0 0 0 0 A0A8C0TIE4 A0A8C0TIE4_CANLF Histone deacetylase (EC 3.5.1.98) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872] DEEAEPPREVEPGQ;DPPMGDAEYL;IVLALEGGHDLTAIC;KALAHRNLNHCISS;TVTAMASLS;VLGMYDTKD 6 6.8 1.0026 -1.1301 10.5799 0 6.51377 0 0 0 0 8.5263 0 0 0 0 7.9219 0 0 A0A8C0TIF1 A0A8C0TIF1_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EEFDVFTKAPFSKKVS;EELLDREFD;GGGGGGGA;GGGGGGGG;INNSSIPSALPE;LNPQKDGVNLVEEE;NPFGEDNFSKLTE;VSNINNSSIPSALPEPMT 8 7.6 0.99021 -0.53525 0 0 0 1.96543 0 10.623 0 0 0 0 0 0 10.8957 0 9.76669 A0A8C0TIG2 A0A8C0TIG2_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526] membrane [GO:0016020] chemorepellent activity [GO:0045499]; semaphorin receptor binding [GO:0030215] CGTNAFSP;CSSNCGGG;GAGGGGGG;GGGGGGGG;GWVPGAVAGS;KQQRCSTLEDSSNMS;PGRWRGPRGVAGS;RCGGRDCLGPAIHIANCSRNGA 8 9.3 1.0034 -1.6406 0 7.38146 0 9.65258 7.40982 0 6.71108 0 0 0 0 0 0 0 0 A0A8C0TIH2 A0A8C0TIH2_CANLF "ETS proto-oncogene 2, transcription factor" Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] FDTFDGSLFAIFPSLNEE;SLNEEQTLQEVPT 2 5.6 0.98857 -0.20414 0 0 0 0 0 0 0 0 0 0 5.5451 0 0 0 0 A0A8C0TII4 A0A8C0TII4_CANLF Cilia- and flagella-associated protein 299 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ILTQFSTYEDFLDSQITTV;YFSGKRRLLPK 2 12.9 0.99243 -0.20655 0 3.5758 0 0 0 0 10.3341 0 0 0 0 0 3.93537 0 0 A0A8C0TII6 A0A8C0TII6_CANLF EH domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; endosomal transport [GO:0016197] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525] EEFALANHLIKV;LMVMVRQEE;NDIARLMVMVRQE;RIGPEPTTDSFIAVMHGPTE 4 8.6 0.99371 -0.056634 0 0 10.7004 0 0 0 11.759 0 0 0 12.2046 0 15.7676 0 0 A0A8C0TIJ6 A0A8C0TIJ6_CANLF FRA10A associated CGG repeat 1 FRA10AC1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634] FLWNEEDEMD;NEEDEMDMNWEKR;SNKRKKRTIEDDLLLKKPF 3 11.2 0.99714 -0.59521 0 0 0 0 0 0 0 6.89203 0 0 0 0 0 0 0 A0A8C0TIK0 A0A8C0TIK0_CANLF Otogelin Canis lupus familiaris (Dog) (Canis familiaris) L-arabinose metabolic process [GO:0046373] alpha-L-arabinofuranosidase activity [GO:0046556] CCPSYSCECDP;CNAWSVST;DSCCPSYSCECDPDLCEAE;DSCCTSYFCACGDCPDPI;DVTWFYSNCLTDTCGCSRGGDC;GDCECFCASVSAYAHQCCQHGVAVD;HPCASTCTAYGDRHY;LCVPRNQCSCHFQGMDYPPGDSD;LDEVTQRCVYLE;LGHCHCKDGV;LQVDQRWADDTVG;LSSALPLI;LVLRLYEHT;NKALGKGP;PFLCSSDSIYQACVA;PPDTYLDT;PRFGEVALLLPTEDP;PSLGHCHC;PVTCGAGG;QEDSCCPSYSC;RTFSACHRFVPPESFCELWIR;SCSVLTGELFAPCSAYLSP;SGSPSPESFLDEK;SLHPCASTCTAY;SPGEAEVL;TSYFCACGDC;VLDSLAMSSWERR;VPACALSCEATKEYSPCVALCG;VTASNLPAHPTEPPA;WIRDTKYVQQPCVALTV 30 12.5 0.99447 -0.56021 0 0 0 0 0 0 11.1822 0 0 0 0 0 0 0 0 A0A8C0TIL0 A0A8C0TIL0_CANLF Phosphatidylinositol binding clathrin assembly protein PICALM Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta clearance by transcytosis [GO:0150093]; axonogenesis [GO:0007409]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of gene expression [GO:0010629]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of DNA-templated transcription [GO:0045893]; receptor internalization [GO:0031623]; regulation of vesicle size [GO:0097494]; synaptic vesicle maturation [GO:0016188]; vesicle budding from membrane [GO:0006900]; vesicle cargo loading [GO:0035459] cell surface [GO:0009986]; clathrin coat of coated pit [GO:0030132]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] 1-phosphatidylinositol binding [GO:0005545]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; tau protein binding [GO:0048156] ASRNTLFNLSNFLDKSGLQ;ATVDAVDDAIPSLN;LLDFNVNSNELTNGV;LPVAKLPP;LSNFLDKSGLQGYDMST;PSSHSPHRASGKDP;SLPVAKLPPN 7 10.9 1.0035 -1.6865 9.59492 9.93474 0 0 0 9.76452 0 0 7.57493 5.45753 9.57429 6.73877 10.223 0 0 A0A8C0TIL7 A0A8C0TIL7_CANLF Protein Hikeshi EED Canis lupus familiaris (Dog) (Canis familiaris) cellular response to heat [GO:0034605]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; nucleus [GO:0005634] Hsp70 protein binding [GO:0030544]; nuclear import signal receptor activity [GO:0061608] MFIPANVVLKWYENFQRR;SNPDLSGDE 2 12 0.97259 0.048313 0 0 0 0 6.96924 0 0 0 0 4.82253 0 0 0 0 0 A0A8C0TIN2 A0A8C0TIN2_CANLF Solute carrier family 9 member C1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216]; sodium:proton antiporter activity [GO:0015385] DLNYTMSNFTLLTK;FDFILTVVFIKIVRFLRILRILK;FIKIVRFLRILRILKLI;FLRILRILKLITPKLLQIID;IHKIESTEINKLIMAKKK;IKIVRFLRILRILKLIT;IVLRLLVFLLLSPLLS;IVRFLRILRILKLI;IVRFLRILRILKLITPKL;KIVRFLRILRILKLI;KIVRFLRILRILKLIT;KIVRFLRILRILKLITPKL;LDFQPVIKPLT;LICTVGGE;LTVVFIKIVRFLRILRILKLI;LVLYIMEALLK;RILRILKLITPKLLQIIDQ;SRFGHGFSWRWAFIMVWSEMKGTPN;TDEFEYVGYLVT;VVFIKIVRFLRILRILKLITP;VVFIKIVRFLRILRILKLITPKLLQ;YKAPSLIPITCYQVQGTEDFTKVMI 22 19.7 1.0034 -1.1044 0 0 0 0 0 0 0 7.49354 0 0 0 0 0 0 0 A0A8C0TIN8 A0A8C0TIN8_CANLF LTD domain-containing protein LMNTD1 Canis lupus familiaris (Dog) (Canis familiaris) RHRFPWPVSRTTTEEKQDKS 1 4.9 0.96385 0.048688 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4485 0 A0A8C0TIP7 A0A8C0TIP7_CANLF Olfactory receptor OR51E2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DVLFIFLSYFLIIRT;ILALFWFDSREITFD 2 9.1 0.99484 -0.18924 0 10.3746 0 5.47518 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TIQ6 A0A8C0TIQ6_CANLF Progestin and adipoQ receptor family member 3 Canis lupus familiaris (Dog) (Canis familiaris) IYTRMEEYVHP 1 8.8 0.98389 -0.24465 0 0 0 0 0 0 0 0 0 0 8.45689 0 0 0 0 A0A8C0TIR4 A0A8C0TIR4_CANLF Zinc finger ZZ-type and EF-hand domain containing 1 ZZEF1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; zinc ion binding [GO:0008270] AGLDLQIFWNFYS;ASAEDVDGEKLNPQDRGSA;EAGAAGGE;ESKHPYNNNTSFEDKVHIPGAIYLS;HLFTMMKNVT;LDLSGPAHMTYILD;LIDQYVGQFV;MEVQVRESKHPYNN;SIEEKAVTPSPEQVFAE;SLDEPTRICFL;STLLSVAA;TDSFFLEVQKRFDG;VGTEKWPRKVIFKAGPRLQF;YVRPMRVE 14 6.3 0.99722 -3.4569 0 0 8.23688 0 0 0 13.4784 10.3049 0 10.1669 0 8.51061 8.76947 0 10.547 A0A8C0TIS7 A0A8C0TIS7_CANLF Ubiquitin conjugating enzyme E2 E2 UBE2E2 Canis lupus familiaris (Dog) (Canis familiaris) AAGGGSGAE;LAVSRGRA 2 4.3 1.003 -1.9086 0 0 0 0 0 0 0 0 0 9.72962 0 10.6363 0 0 0 A0A8C0TIT7 A0A8C0TIT7_CANLF Transmembrane serine protease 7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] FPGVYTRVSNFVPWIHK;IGSDKGCSQYFYADH;KGCSQYFYADHLS;LPGRRAPRKPIGKVKPKKPSKKK;QCDGTVDCPDGSDEEGCSC;RRTSDGQWIL;WWEINEHMYCGSYMDHQ 7 12.5 0.99138 -0.0047189 8.45356 0 12.9158 0 0 4.01257 10.0814 0 5.8775 8.22226 0 3.07257 0 0 0 A0A8C0TIU7 A0A8C0TIU7_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" CSGEPMDP;GGGGGGGD;GGGGGGGG;RLDLVESRVQVWFQN;TEGHRGQQRRS 5 7.6 1.003 -1.5334 0 0 0 6.06299 0 0 0 0 12.5885 0 0 0 0 0 0 A0A8C0TIU8 A0A8C0TIU8_CANLF NAD-dependent epimerase/dehydratase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GPLVTRGPRRGRGLVR;NARKDWGWKHDFDLPELVTTM 2 7.9 0.93598 0.097035 0 3.47586 0 0 0 0 0 0 5.2693 0 0 0 0 0 0 A0A8C0TJ00 A0A8C0TJ00_CANLF Unc-5 family C-terminal like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] netrin receptor activity [GO:0005042] PVSQPPPCNRLPPELFEQLQML;QNYLSLSCSPAPLRGGAH;SPAAAILELFE 3 9.9 0.9879 -0.47037 0 0 0 0 0 0 0 10.4726 0 0 0 0 14.2424 0 0 A0A8C0TJ16 A0A8C0TJ16_CANLF TBC1 domain family member 23 TBC1D23 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794] GGEHLCFMGSGREEEDMY;LSQALCLAISV;LVTATHMYCL;SVSEILQANQLQGEGV 4 7.7 0.99692 -0.59006 0 0 0 0 0 6.99084 0 0 8.96774 7.58158 8.85611 0 0 0 0 A0A8C0TJ20 A0A8C0TJ20_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] AMKGKHKDECHNFIKV;HHAVYVAFSSCVI;LDPVGMSEVPPKVPN;LTWRSRQQDRENCAM;PPELAALP;VAFSSCVI;VIFVGSEAGVVL;VPQTTSVR;VTPGMLLLTE 9 9.4 1.0021 -1.2468 0 9.72748 0 0 0 0 0 10.5897 11.3199 9.49987 8.0197 0 8.63528 14.5553 0 A0A8C0TJ27 A0A8C0TJ27_CANLF Olfactory receptor OR51H2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPGMPKKDFWMALP;IVLDALILLISYFLILQAV;VIILVVIKV 3 13.3 1.0045 -1.0471 0 0 0 0 0 5.77626 0 0 0 0 0 8.6275 0 0 0 A0A8C0TJ36 A0A8C0TJ36_CANLF phosphatidylinositol-3-phosphatase (EC 3.1.3.64) (Phosphatidylinositol-3-phosphate phosphatase) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear envelope [GO:0005635] "phosphatidylinositol-3,5-bisphosphate phosphatase activity [GO:0106018]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]" REELKFWRNMYHQFDRTLHPR;SEYAEEYSKSEPGV;VGVPAPVL 3 5.8 0.9879 -0.47072 20.0828 0 0 0 0 0 0 0 14.3599 0 8.06738 5.52585 0 6.64717 0 A0A8C0TJ37 A0A8C0TJ37_CANLF "Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog)" TAMM41 Canis lupus familiaris (Dog) (Canis familiaris) cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024] mitochondrial inner membrane [GO:0005743] phosphatidate cytidylyltransferase activity [GO:0004605] GPSADQKNAML;VEETLLQVAHDPDCGEVVRLGMF 2 10.9 0.99213 -0.54114 0 0 0 9.1694 0 0 0 9.30859 0 0 0 7.88545 0 0 0 A0A8C0TJ52 A0A8C0TJ52_CANLF Nucleophosmin Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] AADEDDDDDDDD;AADEDDDDDDDDDND;ADEDDDDDDDDDND;DDDDDDDDDNDDEDDDDD;DDDDDDDDNDDEDDDDDDFDD;DDDDDNDDEDDDDDDFDD;DDDDNDDEDDDDDDFDDEE;DDDNDDEDDDDDDFDD;DDEDDDDD;DEDDDDDD;DEDDDDDDDDDNDDEDDDDDD;EDDDDDDD;EDDDDDDDDDNDDE;EDDDDDDDDDNDDEDDD;EDDDDDDDDDNDDEDDDD;EDDDDDDDDDNDDEDDDDD;EDDDDDDFDDEEAE;ELHIVEAE;NDDEDDDDDDFDDEE;VKLAADEDDDDDDDDDNDDEDDDDD 20 13.9 0.2619 0.69837 8.472 9.22381 9.72127 6.52536 0 4.30889 0 7.4054 6.59825 0 0 0 7.94808 9.70499 4.85972 A0A8C0TJ54 A0A8C0TJ54_CANLF Olfactory receptor family 52 subfamily X member 3 OR52X3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVRTKKIREHVLRVLR 1 5.1 0.96381 0.049233 7.38896 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TJ70 A0A8C0TJ70_CANLF Metadherin Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] NF-kappaB binding [GO:0051059]; transcription coregulator activity [GO:0003712] GALPTGKSKKKKKKKKKQ;GEGALPTGKSKKKKKKKKKQ;ITQSGFESGWEQGRER;KKKKKKKK;KKKKKKKKKQSE;LPTGKSKKKKKKKKKQ;SKKKKKKKKK;VADEEVVRTPRN;VILSKSDSDKSSS 9 10.7 0.9894 -0.30426 7.97562 5.98857 0 0 4.86409 0 0 0 0 0 0 4.99612 12.0178 0 0 A0A8C0TJ86 A0A8C0TJ86_CANLF Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] cytosolic large ribosomal subunit [GO:0022625] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GNVGFVFTKEDLT;PTVASVPHSTI;PVAAATTAAPAA 3 13.5 0.94353 0.059632 0 0 0 0 0 7.89409 0 0 0 0 0 0 0 0 0 A0A8C0TJ94 A0A8C0TJ94_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] FCAICSVCEMIQ;GFTDGSRGELSQPTLTIQ;GGCSFDEH;GVMLTIKRRKLAKKQK;IILLGVMLTIKRRKLAKK;IVVHCSAGAGRTGCFIAID;KFVYEVALEYL;LTIKRRKLAKKQ;MVTNLVEVGRHP;PQDGYRIVQ;SRRAADIIECFSVPVSYRN;SYSIYFQALS 12 9.5 1.0031 -2.309 5.57725 0 8.72948 0 10.7193 7.63546 10.8442 0 5.58415 0 0 0 0 5.05858 5.73642 A0A8C0TJB1 A0A8C0TJB1_CANLF Fibronectin type-III domain-containing protein FNDC1 Canis lupus familiaris (Dog) (Canis familiaris) AFKHDPSYTDCHGRQYVKRTWYRKF;AKSLTYPGETTSALV;APLAPPRHPHR;EEAYVIYDEDYEFETSR;GFPIKGPG;GQGLGAGAAAPEGQPSPAVSASQP;LATSGLELPTT;LDVPEDINVRVM;LKPRHVKLL;LVENLIPDTMYE;PATVVNDHVSS;PTIQDLALTWLLSIT;RSALATSGLELPTTMWAG;VEGSISSF;VEGSISSFPGE;VSPAGAPADHPL;YEFETSRPPTT;YSASYEDFIRNKWSTQAS 18 11.2 0.99774 -3.3644 0 11.1806 0 6.1146 8.8631 0 12.5042 9.4412 11.1825 9.68666 0 9.62291 0 0 10.9871 A0A8C0TJE0 A0A8C0TJE0_CANLF NF-kappa-B essential modulator (IkB kinase-associated protein 1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (NF-kappa-B essential modifier) IKBKG Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974] cytoplasm [GO:0005737]; nucleus [GO:0005634] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872] YSWSRTLTCWMSRAPWKSQPSEMV 1 5.4 0.97409 0.041303 0 0 0 0 0 0 0 10.3721 0 0 0 0 0 0 0 A0A8C0TJF2 A0A8C0TJF2_CANLF Transcobalamin-2 (Transcobalamin II) TCN2 Canis lupus familiaris (Dog) (Canis familiaris) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] extracellular region [GO:0005576] cobalamin binding [GO:0031419]; metal ion binding [GO:0046872] PDTPLLEGKSGGHPPLD;SIYIGLRLSSL 2 6.2 0.97846 0.046227 0 0 0 0 4.37434 0 0 0 9.15916 3.86384 3.83441 0 0 0 0 A0A8C0TJF5 A0A8C0TJF5_CANLF RING-type domain-containing protein RNF4 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] MSLKYNKNCPVCLKK;PEMVLEAEL 2 12.7 0.99092 -0.18593 0 0 0 0 0 0 0 0 0 0 0 12.9574 0 8.38862 0 A0A8C0TJF7 A0A8C0TJF7_CANLF FAM186A/B C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LIIETLHTDRV;TFRKSLAS 2 5.8 1.0006 -0.63247 0 0 0 0 0 0 0 0 9.52076 0 0 0 0 0 0 A0A8C0TJG0 A0A8C0TJG0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KSLDPPFLVPYPFR 1 13.9 0.99002 -0.26352 0 0 0 0 0 0 0 0 0 0 0 0 11.7405 0 0 A0A8C0TJH8 A0A8C0TJH8_CANLF Potassium voltage-gated channel subfamily H member 7 KCNH7 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] inward rectifier potassium channel activity [GO:0005242] CDLHKIQREDLLEVLDMY;DETTTLIGLLKTARLLRLVRVARK;DPDVVVIDSSKQ;HYSPFKAVWDWL;KTVNRKLFGFKFPALRVL 5 7 0.98576 -0.42922 0 0 0 9.44371 9.39985 8.97387 0 0 0 0 0 0 0 0 9.47285 A0A8C0TJI8 A0A8C0TJI8_CANLF Olfactory receptor OR4K5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MRNIMTYYL 1 2.9 0.9847 -0.23859 0 0 0 0 0 0 0 0 0 0 0 0 0 9.41346 0 A0A8C0TJJ3 A0A8C0TJJ3_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) NHLRC1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GDRSIKVF 1 2 0.98994 -0.26397 0 0 0 0 0 0 0 0 11.5604 0 0 0 0 0 0 A0A8C0TJJ5 A0A8C0TJJ5_CANLF Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] actin binding [GO:0003779] EKSIDDLEDELY;LQKLEEAEKAADESERGM;QEIQLKEAKH;RETAEADVASL;SEELDHAL 5 13 1.0041 -1.0539 0 0 0 0 0 0 11.1563 0 0 0 0 0 0 0 9.76328 A0A8C0TJJ8 A0A8C0TJJ8_CANLF FHA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATAGHTCSGLPGHSSVDTSNF;GEPTHTEQ;LDLEEEPSAL;SEDMSITSGSESM;SPEKVDQRKSRQL 5 2.5 0.9981 -0.60713 9.14924 0 7.55328 0 0 0 0 8.93319 8.61765 9.37478 0 0 0 0 0 A0A8C0TJM4 A0A8C0TJM4_CANLF Transmembrane protein 126B TMEM126B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NLKFIRFVI 1 3.9 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 4.17185 3.13241 A0A8C0TJM7 A0A8C0TJM7_CANLF Olfactory receptor OR5K6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] AQFYFFCLAETADCFL;DRYVAICSPLQ 2 8.6 0.96354 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.13832 A0A8C0TJM8 A0A8C0TJM8_CANLF Cadherin EGF LAG seven-pass G-type receptor 3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ALAPRGAGAGAAGPWFSSE;ASASTLFRPI;GDFCETEL;ILQLRATDGDAP;LAVFTHVVMAV;NEKHDFLALE;PTCGPCNCD;RMRSRALFRRRFL;RPHTVVLRVTAT;RWHDLRLELQEEPGGRR;SRRSNSGEQLDRV;TGHTEHYF;VGGTVLNVS 13 4.6 0.94075 0.059756 0 8.78018 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TJN5 A0A8C0TJN5_CANLF Aquaporin Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] channel activity [GO:0015267] LRRPEQSGWSTLP;PVYRVPAVA;VLLYHGRLPRLFRRNLL;VTVMAYAAGP;YHGRLPRLFRRNLLYSQR 5 11.1 0.92949 0.09454 0 0 0 0 0 0 0 4.7583 0 4.77442 0 0 0 0 0 A0A8C0TJN7 A0A8C0TJN7_CANLF beta-mannosidase (EC 3.2.1.25) (Mannanase) MANBA Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764] beta-mannosidase activity [GO:0004567] GGWRIRSGNGSLELP;GPLLLLLLLLLLP;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLP;LLLLLLLP;LLLLLLLPLCGA;LLLLLLPL;LPLCGAGS;PLLLLLLLLL;PLLLLLLLLLLP;VGLHKAHI;VTSDLLRLLLQ;YFARHFFAP 15 8.2 0.99148 -0.54519 12.6059 0 3.32812 0 0 5.10178 0 0 0 0 4.53294 0 10.2751 7.75696 0 A0A8C0TJP3 A0A8C0TJP3_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] VLRWRSCSMFLVRMTADGF 1 4.3 0.94988 0.049923 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.63241 A0A8C0TJP6 A0A8C0TJP6_CANLF Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (T-cell activation antigen CD26) DPP4 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121] serine-type endopeptidase activity [GO:0004252] FNDTEVPLIEYSFYSDE;GIEALTSDYLYYISNEY;QWKVLLGLLGLAALVTVITV;SFYSDESLQYPK;SIILHETKFWYQ;VLLGLLGLAALVTVITVP;VSRWEYYDSV;WSYGGYVTSMVL;YAGPCSQKADAVFRLNWATYLAST 9 15.6 0.98741 -0.22938 9.93487 0 9.04204 7.88368 0 4.28096 9.22754 7.87541 0 0 0 5.29271 12.5502 0 0 A0A8C0TJR0 A0A8C0TJR0_CANLF "BOC cell adhesion associated, oncogene regulated" Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AGPYITFT;GRELNGSDDALGILITRGTLVI;PLFHRGPPCCLGLV;VLPSRPGSPDQML 4 4.9 1.0021 -1.2368 0 0 0 7.84386 0 8.32656 0 0 0 4.19188 0 7.43746 0 5.95766 11.0567 A0A8C0TJS4 A0A8C0TJS4_CANLF Olfactory receptor OR5K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DRYVAICSPLQ;KEVITVLRKILRK;RYVAICSPLQYHTMMSKKL;SLRNKEVITVLRKILRKK 4 12.3 0.98631 -0.23194 0 0 0 0 0 0 0 0 0 0 0 5.09925 7.76904 7.51751 0 A0A8C0TJS6 A0A8C0TJS6_CANLF Cytochrome b-c1 complex subunit 7 (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" mitochondrial respiratory chain complex III [GO:0005750] PQVPRSAADAA 1 4.9 0.98306 0.035491 0 0 0 0 0 0 0 0 0 0 11.5933 0 0 0 0 A0A8C0TJU9 A0A8C0TJU9_CANLF Complement C1r subcomponent like Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] FTAGNDLWRSPQ;GVWGYVSGFGV;MPGFTAGNDLWRS 3 5.3 0.99093 -0.5119 0 0 0 0 0 0 0 0 11.881 0 8.28049 0 0 0 0 A0A8C0TJV0 A0A8C0TJV0_CANLF Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) Canis lupus familiaris (Dog) (Canis familiaris) sarcomere [GO:0030017]; sarcoplasmic reticulum [GO:0016529] VSVNEGYKVC 1 1.9 0.99957 -0.61146 8.29043 0 0 0 3.04625 0 0 0 0 0 0 2.95004 0 0 0 A0A8C0TJV8 A0A8C0TJV8_CANLF TM2 domain containing 3 TM2D3 Canis lupus familiaris (Dog) (Canis familiaris) ADCVECKTNFSCV;ISKAGKVK;PETDYECSNST 3 12.7 1.0029 -1.0093 10.22 0 0 6.11218 0 0 0 0 0 0 0 0 0 0 9.17448 A0A8C0TJW0 A0A8C0TJW0_CANLF Solute carrier family 16 member 14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monocarboxylic acid transmembrane transporter activity [GO:0008028] LVRAKRRVPSD 1 2.7 0.98326 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 7.03991 0 0 A0A8C0TJW8 A0A8C0TJW8_CANLF Protein tyrosine phosphatase receptor type E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AYFFRFRK;IDGYRQKDYFIATQGPLAHTV;LAWLLLPLLLCVLLLLL;LKFLKKVKAL 4 6.3 0.98527 -0.43929 7.34296 10.829 0 4.06833 0 8.75097 0 0 0 0 4.99571 0 4.20242 8.31927 4.36359 A0A8C0TJW9 A0A8C0TJW9_CANLF Cilia- and flagella-associated protein 418 CFAP418 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917] ACDFRVVSYDDYMWDHSC;DPQLRWEGREQGVTC;WDHSCDYLFFRNNMPE 3 16.5 0.9937 -0.14932 0 0 0 7.23237 0 0 0 0 7.95391 9.33056 0 0 0 0 0 A0A8C0TJY8 A0A8C0TJY8_CANLF EF-hand domain-containing protein GCA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] calcium ion binding [GO:0005509] IIMYFLLLFTIK 1 5.2 0.95419 0.05044 0 0 6.34901 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TJZ1 A0A8C0TJZ1_CANLF Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) Canis lupus familiaris (Dog) (Canis familiaris) 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749] GCFLGGKSL 1 2.6 1.0045 -0.80421 0 0 0 0 0 0 0 0 10.3642 0 0 0 0 0 0 A0A8C0TJZ9 A0A8C0TJZ9_CANLF Myosin IG MYO1G Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ADRWAPHRRP;AILHLGNV;DLVVCLHRSRP;EACSAAGT;EEYEREGIAWQSVDYFN;ERNFHAFYQVL;LPEPTQNLSTQERQGPVP;LVSVEPKPEQPEPE;RLIPIIVLLLQK;VEPKPEQPEPEFR;VRKVNRFHK;YARDACAK 12 11.8 0.99918 -3.0624 0 0 0 0 4.07013 12.5798 0 0 8.54651 0 2.74947 8.69042 0 0 0 A0A8C0TK01 A0A8C0TK01_CANLF Ankyrin repeat and FYVE domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AICTRGADMSV;DEKGNPPL;GANPNLQTEEA;LEQKANALHATNNLQIIPD 4 4.2 1.0015 -0.70078 0 0 9.27942 0 0 0 0 0 8.72915 9.49207 0 0 0 0 11.005 A0A8C0TK05 A0A8C0TK05_CANLF Multiple inositol-polyphosphate phosphatase 1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] AGCGSCTGC;PWRWRCCRR;QTGSGARARPLRKPGAGRGLGLSA;RGAGGGAG;RGGAGPGP 5 7.2 1.004 -1.0795 0 0 0 0 0 0 0 0 0 0 4.94645 5.93758 0 0 0 A0A8C0TK09 A0A8C0TK09_CANLF Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; vesicle fusion [GO:0006906] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuron projection [GO:0043005]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] KTIIQMGS;VLRLVLLRA 2 7.3 1.0024 -1.4462 0 0 0 0 0 0 0 5.36026 0 0 0 0 3.47496 3.79867 0 A0A8C0TK14 A0A8C0TK14_CANLF S1-like RNA binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LSSDRWRPQS 1 3.6 0.98702 -0.23137 0 0 0 0 0 0 0 0 0 0 0 0 10.0399 0 0 A0A8C0TK31 A0A8C0TK31_CANLF Olfactory receptor OR51AG3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TRSAALHLPLPVLLRRLQFQ 1 6.3 0.96392 0.048658 0 0 6.58714 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TK36 A0A8C0TK36_CANLF DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; circadian regulation of gene expression [GO:0032922]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein dimerization activity [GO:0046983] PGATPTPL 1 1.6 0.989 -0.26277 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3856 0 A0A8C0TK39 A0A8C0TK39_CANLF "Ciliary rootlet coiled-coil, rootletin family member 2" Canis lupus familiaris (Dog) (Canis familiaris) EQEQAGARERLARAEQ;LAEAEEGDLPSL;LETTEARLRRSEL;SPSPRWPVCPRGWVWGRAQSR 4 4.4 0.98966 -0.22237 0 10.2521 7.26209 3.62387 0 0 0 0 12.9431 0 3.13608 0 0 10.4175 6.53094 A0A8C0TK40 A0A8C0TK40_CANLF T-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ARRPRRGAGP;PAPARARAPPPRREPRRRRRSRRRR;SPAGMHFSTVTRDME;VPGRRLRP 4 7.8 1.0032 -1.9115 0 0 0 0 0 0 0 0 9.92884 3.66403 6.2806 0 0 0 0 A0A8C0TK53 A0A8C0TK53_CANLF Ras association domain family member 8 RASSF8 Canis lupus familiaris (Dog) (Canis familiaris) ELQIEQENEKQLKD;ISLNKWGQYASDVQLILRR;QIQTMESGLEAEKL;SRRRSPQHFWS;VEIEEEEFWENELQIEQ 5 10.7 0.99259 -0.050157 10.722 9.02688 0 0 0 8.48083 0 6.90364 0 0 0 0 0 0 0 A0A8C0TK55 A0A8C0TK55_CANLF Transmembrane protein 132B TMEM132B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CVAELELLPEWFSSG;EEDGKWENNI;ELLPEWFSSGL;PNIDEHQGGTNDI;SPLPISFFRETE;TRDSEDEEDEEKKG;TTVNFTHQ 7 6.8 1.0029 -2.4617 0 9.64082 0 0 0 6.43566 9.19525 0 0 8.62029 0 0 0 0 0 A0A8C0TK68 A0A8C0TK68_CANLF BEN domain-containing protein BEND4 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] APAAPQGPPRTSAPP;LSGSFPTPNTSSVSEY;QHHNQLLVPQPADQPT 3 8.8 0.85714 0.15237 9.11616 0 0 0 0 0 0 0 0 0 6.84411 5.54813 0 0 0 A0A8C0TK74 A0A8C0TK74_CANLF Transcription factor GATA-4 (GATA-binding factor 4) Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; tissue development [GO:0009888] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" AGPFDSPV;EMRPIKTE;SGGGSGGA 3 5.4 1.0021 -1.2926 0 0 0 0 0 0 9.72098 4.38108 0 0 0 0 0 0 0 A0A8C0TKA5 A0A8C0TKA5_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] AYHCSKCLEKVP;EADPAEVGEASGE;LVYVLYAVLV;RYRCNETPRRLHLDVYSSNVHS;SYVLSQKH;VGEASGESTRDPTVNL 6 16.5 0.98888 -0.26501 0 0 0 0 0 9.69471 0 0 0 0 0 0 0 0 0 A0A8C0TKB2 A0A8C0TKB2_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ESRPLHKKKKR;FELEEMIL;GRSPHRAPRSPR;IEHVFLVNLW;SRPLHKKKKRLAKN;VGVLAYELL;VLWQDLSE 7 11 0.95423 0.05044 4.16027 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TKD2 A0A8C0TKD2_CANLF Synaptonemal complex central element protein 2 Canis lupus familiaris (Dog) (Canis familiaris) synaptonemal complex assembly [GO:0007130] central element [GO:0000801] ETVYKDLCIQ 1 6 0.99847 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 9.00593 0 A0A8C0TKE6 A0A8C0TKE6_CANLF SEC7 domain-containing protein GBF1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] guanyl-nucleotide exchange factor activity [GO:0005085] AASIYSSWAEEQR;ALVPYGLPCI;ASVESIPEVLE;ATRGGHSDDDEDEGV;DEALRLYLEAF;FLLFESMREHLK;GVKPPAAL;LLECIGSG;QEKRGKSHKYDSK;SDLEEAAD;TGAGALGREMAPGQRI;TLSSNLTGG;VGLLRLAIRLLR;VGLLRLAIRLLRR;VGLLRLAIRLLRRE;VWQTVRDHLYH;YDCDYYCSNLF 17 8.6 0.99668 -4.8309 6.18263 13.7591 0 8.49193 0 7.75896 9.00868 6.81019 8.38836 4.22882 10.6314 0 4.55293 9.44512 5.12809 A0A8C0TKE8 A0A8C0TKE8_CANLF Metabolism of cobalamin associated D MMADHC Canis lupus familiaris (Dog) (Canis familiaris) cobalamin metabolic process [GO:0009235] GVGGGALRGWAWGRGAL;GVGGGALW;SGVGGGAL;VGGGALRGWAWGRGAL 4 5.1 1.0031 -2.4198 0 0 12.6938 0 0 8.55662 0 0 0 0 0 0 0 0 6.74093 A0A8C0TKF0 A0A8C0TKF0_CANLF "Mucin 2, oligomeric mucus/gel-forming" Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] CATKGIMLWGWREQVCNED;CGPNGTVERHFNVCVT;CSCDSGGDCECFCSA;CSCDSGGDCECFCSAVASYAQEC;DCNTCTCQRGRWTCTQSVCYGSCSI;DECEWHYEPCGNRSF;DPDGCCWHWECDCYC;DSCSCDSGGDCEC;DSCSCDSGGDCECFC;DSCSCDSGGDCECFCSAVAS;DSCSCDSGGDCECFCSAVASYAQ;DTCNCQNSESCMC;EACVHDSCSCDSG;EDQKPGGLIPQ;EEHHMDGCFCPEGT;FYEACVHDSCSCDSGGDCE;GCCWHWECDCYC;GVVCDDPEEE;HDSCSCDSGGDCEC;LDPDGCCWHWEC;NCQNSESCM;NECEECVCTAGRW;NVECCYLPDYCVSTPPPLPP;PDLNHHHPPTT;PITTTPTTTPTS;SCDSGGDC;SCSCDSGGDCEC;SCSCDSGGDCECFC;SNCHDKLDWLDDP;TTTPSTTTPLTP;VEEITSKVDNFGVYI;VHDSCSCDSGGDCECFCSAV;YSPGDKIKVDCNTCTCQRGRWTCTQ;YYKRCKYDTCNCQN 34 9.3 1.0018 -1.3103 10.7004 9.34521 14.2242 0 8.63862 10.5128 8.33476 11.2253 0 9.28556 9.02868 8.95919 9.25439 8.69943 9.87258 A0A8C0TKH8 A0A8C0TKH8_CANLF RNA polymerase III subunit D POLR3D Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase III [GO:0006383] RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677] EDGQMVVIKQ;QVGKLLIRKSGKVQLLLG;VLGHIKHKLI 3 9.8 0.99699 -0.58936 0 0 7.57342 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TKH9 A0A8C0TKH9_CANLF VWFA domain-containing protein INTS6L Canis lupus familiaris (Dog) (Canis familiaris) snRNA 3'-end processing [GO:0034472] integrator complex [GO:0032039] GVPVGHWPIPESFWPDQN;IKEAARFKRRVLIQYLEKV;KNHSGGGV;LHTFGNPFKQDKKGMMID;MENGQISPDGFLSKSA;VISYLKKLSQQTK 6 10.2 1.0026 -1.1499 0 0 0 6.05819 5.81442 6.54716 4.76787 9.71493 0 0 0 0 0 0 9.33192 A0A8C0TKI9 A0A8C0TKI9_CANLF Adhesion G protein-coupled receptor B2 ADGRB2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ADPEESSSYFVIGA;AGEIIYNK;FKEVNTCNPSTITG;GAGEDPPR;GASLWSSC;LDHYLVNFTCLRP;PGCSCPGE;PPTPSARQVSEP;PSACSALASGVLYG;SPEEAGAQAEA;SQVVRSLQE;VSAVSSDITF 12 8.4 0.99755 -3.4152 8.78483 0 0 8.94869 0 9.87113 13.0085 0 10.7837 8.96728 7.52623 0 9.43979 0 0 A0A8C0TKJ6 A0A8C0TKJ6_CANLF "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Steroid 17-alpha-monooxygenase)" CYP17A1 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" KLILLEATIREVLRIR;NCVKMRDDLLNEILE;VVTMDILSDNQK 3 9.9 0.94891 0.05044 0 0 0 0 0 0 0 0 0 6.76381 0 0 0 0 0 A0A8C0TKL0 A0A8C0TKL0_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EQNLHEPMYYFLSML;SCPLTQSLIMLVLNN 2 9 0.93049 0.10778 9.02569 0 0 0 0 0 0 0 0 0 0 3.13763 0 0 10.653 A0A8C0TKL1 A0A8C0TKL1_CANLF BTB domain-containing protein KCTD10 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463] ubiquitin-protein transferase activity [GO:0004842] CQAALQQNKDTYEPFC;VGGALYYTTMQTLTKQDTMLKAMFS 2 13.1 0.98891 -0.52407 9.08068 8.86688 0 0 0 0 8.8427 8.85034 8.81346 0 0 0 0 0 8.31692 A0A8C0TKL4 A0A8C0TKL4_CANLF Calponin-homology (CH) domain-containing protein TAGLN3 Canis lupus familiaris (Dog) (Canis familiaris) RGPSYGLSRE 1 5.7 0.98912 -0.26139 0 0 0 0 0 8.82024 0 0 0 0 0 0 0 0 0 A0A8C0TKM8 A0A8C0TKM8_CANLF Phosphatidylserine synthase (EC 2.7.8.29) (Serine-exchange enzyme) PTDSS1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylserine biosynthetic process [GO:0006659] endoplasmic reticulum membrane [GO:0005789] L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245] AGIYLFMIIWQ;HVITWERIISHFD;SRGLHRPLQGLGELWA 3 5.8 0.98961 -0.52635 0 0 0 0 9.07229 0 0 0 0 0 0 0 0 11.0906 0 A0A8C0TKN5 A0A8C0TKN5_CANLF Olfactory receptor OR4K1 OR4K1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLLVGMAYDRFIA 1 4.2 0.98751 -0.23439 0 0 0 0 9.53421 0 0 0 0 0 0 0 0 0 0 A0A8C0TKP5 A0A8C0TKP5_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP30 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DIYKYHLLGHKPG;ITERKKRRKGLVPGL;VLSSSAYL 3 7.4 0.98652 -0.39591 0 0 10.6208 0 10.5044 0 0 0 0 0 0 7.39481 0 0 10.0251 A0A8C0TKQ5 A0A8C0TKQ5_CANLF Interleukin 22 IL22 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ISSHCRLDKSNFQQP 1 8.4 0.94494 0.079285 9.16025 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TKR9 A0A8C0TKR9_CANLF Magnesium transporter MRS2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] mitochondrial inner membrane [GO:0005743] APLCEPQR;KSSAGIDHAEEMEL;LNESPLPLQKLKRVLVI;VAFGMNLESSLE 4 10.9 1.0019 -1.4621 0 0 0 0 0 0 0 0 9.58538 0 0 0 0 0 12.6911 A0A8C0TKT4 A0A8C0TKT4_CANLF Olfactory receptor OR51G2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MKLACADIKANS;YLVSILGNCTILF 2 8 0.99044 -0.53612 0 0 0 0 0 0 10.1552 0 0 0 0 0 0 0 9.71325 A0A8C0TKV5 A0A8C0TKV5_CANLF Fe2OG dioxygenase domain-containing protein ALKBH2 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] SLPVRKKIL 1 3.5 0.99207 -0.27195 0 0 0 0 0 0 0 0 0 0 0 10.2207 0 0 0 A0A8C0TKZ1 A0A8C0TKZ1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) KIPWTSFKELEQI;MDAFLESHKL;MNEKGEITTNT 3 4.7 0.98241 -0.25043 0 0 0 0 0 0 12.2214 0 0 0 0 0 0 0 0 A0A8C0TKZ3 A0A8C0TKZ3_CANLF Zinc finger protein 638 ZNF638 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] ESAQSMYSFLKQ;EVYNLVKP;GAEKAEKSDARMV;GVPDVPEDLDFL;KIFQPFGKVNDVLI;LVTVDEIQDDSSDL;SEKSNMDEKEENEFNS;SELDYRDITKQ;TDEVKNEFRS;TEQSPQVQSRYTKE;YTCFPISMDGNQL 11 7.1 1.0032 -2.2857 0 0 0 9.52536 7.54048 5.53101 7.58015 12.9673 0 10.6246 0 0 9.8752 6.29565 0 A0A8C0TL02 A0A8C0TL02_CANLF Coiled-coil domain-containing protein 80 Canis lupus familiaris (Dog) (Canis familiaris) EDEYAGYGYHSYHQGYQDGYQDD;HLPAAKRGSHGARGAP;LEKLEKLEK;LLKAKKEKAEKKSRQEKEKSK;YHSYHQGYQDGYQDDYRHHESYH 5 8.6 0.99577 -0.5671 0 0 0 6.02631 0 0 0 0 0 0 0 12.7438 0 0 7.99107 A0A8C0TL10 A0A8C0TL10_CANLF Single stranded DNA binding protein 4 SSBP4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] single-stranded DNA binding [GO:0003697] AKGGKGSA;DMDGLPKSSPGAVAG;ESVSDCVDSPPAAASGRRG;MSAMEPHHVNGSL 4 13.5 0.98931 -0.26592 0 0 0 0 9.6858 0 0 0 0 8.89884 9.20342 9.06299 0 0 0 A0A8C0TL13 A0A8C0TL13_CANLF Dual specificity phosphatase 28 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AAVRAGGACLVYCKNGRSR 1 10.2 0.94988 0.049553 0 0 0 0 0 0 7.85891 0 0 0 0 0 0 0 0 A0A8C0TL37 A0A8C0TL37_CANLF Cadherin domain-containing protein PCDH15 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; sensory perception of sound [GO:0007605] adherens junction [GO:0005912]; catenin complex [GO:0016342]; stereocilium [GO:0032420] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] DSEEESEPGSSGSSSSSSS;ELGDSTMYEMPQ;ESETPSEEEESST;GVSEDARMFTS;PYLPRNLSVVEE;QEEATESTVESEEESSSDYT;SEPVIVNIRVMD;SLGYTEGAL;SSTPESEESESTESE;VEENLPAGTTFLQ;VGEAEEEEEYEEEEE 11 8.3 0.99029 0.023146 0 6.78162 8.68534 0 0 13.9429 0 0 0 0 0 9.45718 4.8296 17.5759 8.32143 A0A8C0TL39 A0A8C0TL39_CANLF "Mucin 5AC, oligomeric mucus/gel-forming" Canis lupus familiaris (Dog) (Canis familiaris) ACDSGGDCECFC;CGSPCADTCSNPEHSQLCEDHC;CVGDACACDSGGDCEC;DACACDSGGDCECF;DIQLVPIMQVFVRL;DSGGDCECFCT;DTCSNPEHSQLCEDHCM;EACVGDACACDSGGDCEC;GDACACDSGGDCECF;GDACACDSGGDCECFC;HTCPFTCPADKVYQ;LDELGQDVICDKS;NCMFDTCN;NCMFDTCNCEKSEDCL;PEYITQLECRAE;PPVKVTDHDDCCPNYQCQCVCSGW;PTVGLVCYNRNQ;QRINCMFDTCNCE;SSPMSHKTSVQPHVTCGEECL;TEQCQDPVPVPMMDCSPGSSICE;VGDACACDSGGDC;VGDACACDSGGDCEC;VGDACACDSGGDCECFCTA;VGDACACDSGGDCECFCTAV;VTDHDDCCPNYQCQC;VTENVPCGTTGVTCSKAIK;YYNPEGQC 27 6.6 0.81777 0.20293 0 0 7.17003 7.32337 0 0 0 0 0 0 0 7.64587 0 0 0 A0A8C0TL90 A0A8C0TL90_CANLF Hydroxylysine kinase Canis lupus familiaris (Dog) (Canis familiaris) EKFHHPKLSCLHRENFI;TASVCRSKGGGLTSLV 2 14.9 0.92569 0.09546 0 0 0 0 0 6.89966 0 0 0 0 0 0 0 0 8.53033 A0A8C0TL91 A0A8C0TL91_CANLF Potassium voltage-gated channel subfamily H member 3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated potassium channel activity [GO:0005249] GAHLLKTVRLLRLLRLLP;HLLKTVRLLRLLRLL;LLKTVRLLRLLRLLP;QVLAPHGEG;RPGRAGASQAGAGPSVHPRSLEG;SDQPKFSFR;VRLLRLLRLLP;VTELSEQVLQMREGLQ 8 7 0.99246 -0.15108 0 0 0 10.9811 0 6.87504 8.79318 11.0798 10.936 2.56369 12.0361 0 9.78192 0 0 A0A8C0TL93 A0A8C0TL93_CANLF Translocase of outer mitochondrial membrane 70 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039] mitochondrial outer membrane [GO:0005741] mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320] GATAGAGA;IDMFNKAINLAKSEMEMA;SAVGGGGATA;TYVHKGLL 4 6.6 0.98754 -0.48456 0 0 0 7.51389 0 0 0 0 0 0 8.58913 12.5094 0 9.42141 9.33152 A0A8C0TL98 A0A8C0TL98_CANLF Inositol polyphosphate-5-phosphatase J INPP5J Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; phosphatidylinositol dephosphorylation [GO:0046856] cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; plasma membrane [GO:0005886]; ruffle [GO:0001726] "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]" EAHLQPSAP;GLEEGGLG;VLSSSQEQALAPASVTS 3 3.4 1.0016 -1.2571 0 0 0 3.46205 0 12.8389 7.96682 0 8.5043 0 0 9.47291 0 3.39218 0 A0A8C0TLA1 A0A8C0TLA1_CANLF Peroxiredoxin-2 (EC 1.11.1.24) (Thioredoxin-dependent peroxiredoxin 2) PRDX2 Canis lupus familiaris (Dog) (Canis familiaris) peroxiredoxin activity [GO:0051920] GAENVCSR 1 2.9 1.0031 -1.1044 0 0 0 0 0 0 0 0 5.75796 7.56605 0 0 0 0 0 A0A8C0TLA9 A0A8C0TLA9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] "racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]" EDTKTPGALIKDTWE 1 8.1 0.95399 0.053902 0 0 0 0 0 0 7.53138 0 0 0 0 0 0 0 0 A0A8C0TLB6 A0A8C0TLB6_CANLF High mobility group nucleosome binding domain 1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] AAGKSLEDLRHPEVPASAAEEGNP;GGGGGGGG;GGGGGRPG 3 18.1 0.99301 -0.28024 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4351 0 A0A8C0TLC0 A0A8C0TLC0_CANLF Laminin subunit alpha 5 LAMA5 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; tissue development [GO:0009888] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] AYTALKFYLQSPEQEPG;DLRRGFEAFPELYWQAPP;EPRILCRADRRP;GSSCQPCDCSGN;GVADGDCD;GVRHETAQ;HGYPSCRPCDCHEAGSMPSV;LAQASRLLDSTEASLGRAQ;LCMCPANYRGDSCQEC;LGEAGHAVLSVDEDI;LTGRCYCRPNFTGERCD;LVSSSGIIFFMQHQD;PGAPPEGPQP;PYSALCRATALD;QRGFGEPFVLNPGTWALVVEAEGVL;RGGPPCQWLQPPAASGRR;RRCNCESDFTDGTCEDLTGRCYCR;RRCQCQGGHCDVHTGRCTCPP;SCNCHGHAHDCFYDPEVD;SPHACRRCN;TGACRCRPNTQGLT;VAGGDPNQTIQGQYCD;VEHNSTLELADSYYLGGVPPDQL;VEKQMLHETKGD;VGCVLRGGRTQCLCK;VGSYPSNFTPP;VQAMLAMDTDE 27 11.2 0.99913 -3.1741 10.2472 9.68226 0 8.98766 9.17408 11.1787 11.0955 11.381 11.2532 11.0421 0 10.5162 13.1722 10.1307 10.7766 A0A8C0TLE7 A0A8C0TLE7_CANLF Translation elongation factor EFTu-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] SKMSTKLVVL 1 5.1 0.99236 -0.2719 0 0 0 0 0 0 0 0 0 11.3987 0 0 0 0 0 A0A8C0TLF3 A0A8C0TLF3_CANLF G-protein coupled receptors family 3 profile domain-containing protein GSG1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FLWLNTVDPAFEFI;LAIIGIVVTIILLLAYLFLLRR;LLQVIIAIEYVTLMMT;LVYVLFLMALTFFI 4 14.3 0.99688 -0.09079 0 0 0 9.48049 0 5.41024 0 0 9.18135 0 0 4.80576 0 0 0 A0A8C0TLH0 A0A8C0TLH0_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] AALCAGAP;GGGGGGPG;LPRDSRARF;SRGAGGGG 4 8 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 12.5532 0 A0A8C0TLI0 A0A8C0TLI0_CANLF Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" RGGGCPGLRSTHTWCGI 1 4.6 0.97762 0.04739 0 7.53021 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TLI4 A0A8C0TLI4_CANLF Nuclear factor 1 NFIX Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KSIDDSEMESPV;MYSPYCLTQ;STAPDGAALTPPSPSFATTGASSA;TSGVWNVTELV 4 11.2 1.0025 -1.0037 9.04742 0 0 9.75694 0 0 0 0 9.05094 0 6.35466 8.78562 0 0 9.36986 A0A8C0TLK3 A0A8C0TLK3_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN6 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] AGLGSPLRVTHIKVMC;VLSFLDQINQRQE;YHGHMSGGQAETLLQAKG 3 8.6 0.81967 0.20544 8.78584 0 0 12.5079 0 0 0 0 0 8.00326 0 0 0 0 0 A0A8C0TLM4 A0A8C0TLM4_CANLF Rabphilin 3A Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] membrane [GO:0016020]; synapse [GO:0045202] metal ion binding [GO:0046872] EFNEEFFYDIKHSD;GFCEGGGV;GLIVGIIRCVHLA;VGGYSAPGAREDR 4 7.6 1.0019 -1.3035 0 6.75462 0 0 0 0 8.45619 0 0 0 2.15672 6.88911 0 0 0 A0A8C0TLN3 A0A8C0TLN3_CANLF Sulfatase 1 SULF1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; Golgi stack [GO:0005795] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] ACSKQREAAQEVDSKLQ;CLRTVNETHNFL;IVKRHDEGHRGPGGHQAPG;KENRRRKKER;KWLEHEERNHLET;TYWCLRTVNETHNF;VLATELLGGHCSTV;VYTNNENCSSPSWQAMHE 8 9.4 1.0033 -0.88965 3.26341 10.4808 0 10.0123 0 12.0872 0 9.7077 0 0 0 8.849 0 8.72972 0 A0A8C0TLQ2 A0A8C0TLQ2_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] GGGGGGGG;GGRGGGGG;HDHRPEPGGDDGGGV;HVGPRAAGAAAGGRAG;LPGGGGPG 5 9.6 0.98737 -0.32398 0 0 10.6005 0 0 0 0 0 0 12.0352 0 0 8.93882 0 0 A0A8C0TLQ6 A0A8C0TLQ6_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IKRLKKKKKKK;IKRLKKKKKKKKKTFK;KKKKKKKK;KRLKKKKKKKKKTFK;RLKKKKKK;SIKRLKKKKKK;SIKRLKKKKKKK;SIKRLKKKKKKKKK 8 2.6 0.6875 0.2853 0 0 7.96861 0 0 6.63442 8.00787 0 0 5.51485 7.52818 0 0 2.7222 8.6355 A0A8C0TLQ8 A0A8C0TLQ8_CANLF Sorbin and SH3 domain containing 3 Canis lupus familiaris (Dog) (Canis familiaris) EEFPRSTFNCNPGAPSSLHQ;IETRQPSPKSSQ;KVNENWYEGRISGTGRQGIFPASY;LSPHRMAD;PAAPVPSA;PLTPHSPG;RPASAWSTSSPNALYQ;SPRNLWCLL;WDIPWKLCSSG 9 12.3 0.99737 -3.7691 10.192 0 12.5402 0 0 0 0 11.5233 0 0 0 0 0 9.24322 9.46875 A0A8C0TLQ9 A0A8C0TLQ9_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DRYVAVCHPLQY;NRRCGWLWSKFEISL;SISFGGCAA 3 12 1.0014 -0.99673 0 9.62238 0 0 0 0 0 0 6.80903 0 9.7525 0 0 0 0 A0A8C0TLR8 A0A8C0TLR8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;PSICCLLETHFRQKDNYSL 3 3 0.95008 0.049724 0 0 0 0 0 0 0 8.11546 8.29792 0 0 0 0 0 0 A0A8C0TLS0 A0A8C0TLS0_CANLF Zinc finger protein 699 ZNF699 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSLLLPIIR;NIGSLDNECHINSRN;YHDTYYQNKSH 3 5.1 1.0045 -1.0516 0 0 6.01728 0 0 0 0 0 0 0 0 0 0 0 7.7003 A0A8C0TLT1 A0A8C0TLT1_CANLF "RAD23 homolog A, nucleotide excision repair protein" RAD23A Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502] damaged DNA binding [GO:0003684]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; ubiquitin binding [GO:0043130] FIQMLNEPPGEL;SPSEESVPTTSPE;TLQQQTFKIRMEPDE;VLAGRPGWPPHCLRARSD 4 10.7 0.98519 -0.23622 0 0 0 0 8.3175 10.967 7.89245 0 0 0 0 0 0 0 0 A0A8C0TLV1 A0A8C0TLV1_CANLF "1,4-alpha-glucan branching enzyme (EC 2.4.1.18)" GBE1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] "1,4-alpha-glucan branching enzyme activity [GO:0003844]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" AAPAARADCSEEALAAALAD;CIQLMAIMEHAYYASFGYQ;ESHVGISSYEGKIASYKHF 3 8.6 0.85239 0.14958 0 9.09911 0 0 0 0 0 6.41892 0 0 0 0 0 6.31931 0 A0A8C0TLW7 A0A8C0TLW7_CANLF Prokaryotic-type class I peptide chain release factors domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] translation release factor activity [GO:0003747] IVYKEKQEAEKKKQERKRRAKETLE 1 15.1 0.97423 0.035538 0 0 8.78077 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TLX1 A0A8C0TLX1_CANLF Phosphotransferase (EC 2.7.1.-) GCK Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] STLARAPQHHGSL 1 2.3 0.98431 -0.23825 0 0 0 0 0 0 0 9.89242 0 0 0 0 0 0 0 A0A8C0TLX6 A0A8C0TLX6_CANLF Aminotransferase class V domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPGDYYTL;QTKNPLTLAVSGS;SEVPSSPV 3 5.3 1.0032 -1.4942 0 0 8.09085 0 0 0 0 0 8.00445 0 1.76362 0 0 0 0 A0A8C0TLY0 A0A8C0TLY0_CANLF Tetratricopeptide repeat domain 23 TTC23 Canis lupus familiaris (Dog) (Canis familiaris) ATAHGSSECLQIQTLLY;ESKETHISNHLDEIVA;FLQAHLIVLSK 3 8.6 0.98541 -0.25823 0 0 0 0 0 8.63318 0 0 0 0 0 0 0 0 0 A0A8C0TM05 A0A8C0TM05_CANLF BTB domain and CNC homolog 1 BACH1 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GVRDIEESCFQFLRFKFLDSTAD;SEKEKSTPDGFPFLQL;TTLSSVNCPFISTLSTEG 3 8.1 0.9872 -0.4048 12.1264 0 0 5.83683 5.65495 0 0 0 0 0 0 0 9.69945 0 0 A0A8C0TM32 A0A8C0TM32_CANLF Rac GTPase activating protein 1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] FSTPQTPS;LVKTFKLKKREKRR;LVKTFKLKKREKRRSS;LVQDFKPEPEARCCL;SLVKTFKLKKREKR;TVKELKEKFLRVKTVPL 6 7.8 0.99047 -0.51201 0 0 0 3.99141 0 0 13.9331 0 0 0 6.20723 0 7.43746 5.30757 0 A0A8C0TM34 A0A8C0TM34_CANLF Partial AB-hydrolase lipase domain-containing protein LIPK Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ISYWGYPHEEYDV;VLSSKRTFYTMTQAAPEG 2 6.4 0.98645 -0.42421 0 0 0 0 9.07127 0 9.85501 0 0 0 0 0 0 0 0 A0A8C0TM65 A0A8C0TM65_CANLF tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) TRMT1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; tRNA modification [GO:0006400] metal ion binding [GO:0046872]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]; tRNA (guanine(26)-N2)-dimethyltransferase activity [GO:0160104]; tRNA binding [GO:0000049] AKIAFPSANEVFYN;FQVSLSHACKNAVKTD;NVQLNGVAHLVHPR;PCGEERPSEIQETT;VLHSLDLRANCYQRFVV 5 11.9 0.68151 0.28319 8.86484 0 10.3972 0 0 0 9.95172 0 11.9625 9.25965 0 0 0 0 0 A0A8C0TM73 A0A8C0TM73_CANLF Membrane bound O-acyltransferase domain containing 1 MBOAT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] GAGGRAGA;ISLLIILFLPIKPHAHI;LMIVTQKI;MTLVSLLLFLTLTKTFPVT;QTATWLKRVCYE;TIFGIYFVIFCFGW 6 14.4 1.0022 -1.2467 0 0 0 0 0 0 0 0 0 0 5.92955 7.49881 0 0 11.5426 A0A8C0TM78 A0A8C0TM78_CANLF P-type domain-containing protein SI Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] apical plasma membrane [GO:0016324] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DVDYMEAKKDFTY;DVPTSTYENRLYDVEI;FSSKAPECYFPRQ;GTAASNTLYDVQ;HANTVQGYVPDAR;IIGMMEFSLF;ISLIVLFVIVTIIAIALIAVLAT;IYGFGEVEHTAF;LKLNLGGNFTVQW;LVYSDQYLQ;MPLVGADICGFVVNTTE;MVAAQIPYDVQYTDI;NTWGMFTRDQ;PWCFFVDNHGYNVG;SFVHGTVS;VLHYNVHN;WCFFVDNHGYNVG;YDYETGAKRPWKKQRVNMYLPGD 18 12.6 0.99894 -3.2378 8.33669 9.24764 5.0201 0 0 9.29239 10.2021 10.5328 10.4057 11.3175 11.2538 10.4949 7.67603 9.21327 7.72363 A0A8C0TM83 A0A8C0TM83_CANLF MAP7 domain containing 3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] DEADDEDESESDDGSSDD;EADDEDESESDDGS;EALLESMETSP;EQRRISAEEKRKQK;ESSPKPKVEAAPEA;NTYEEDEADDEDESESD;YEEDEADDEDESESDDGS 7 6.3 0.99094 -0.26796 0 0 0 0 0 0 0 0 0 0 0 0 9.47139 0 0 A0A8C0TM85 A0A8C0TM85_CANLF Death inducer-obliterator 1 DIDO1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190]; DNA-templated transcription [GO:0006351] metal ion binding [GO:0046872] EEDDRPYDPEEEYG;EEWFHGDCVGISEARGRL;EGTPSWASD;EPERAAEW;GEDEDDTSDSDSD;KEDRRAEERTTAP;PHNNRFMICCDRCEEWFHGDCVGI;REHGRERKDRSK;STSEGKGG;VLTTVTVSGRDP 10 5.5 1.0037 -2.3923 0 0 0 0 0 9.22689 0 6.31296 7.03969 8.36089 9.49414 0 7.9043 0 0 A0A8C0TM98 A0A8C0TM98_CANLF Atrophin 1 P3H3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription corepressor activity [GO:0003714] AGYKTASP;AGYKTASPPGPPPYGKR;LVEKVRREAE;PGLHPFPFHPSLGP;PGYKPGSPPSF;PPQSQQQQPQQ;SSSSSSQGSYPCSHPSPSQGPQ;VGAPSGGKQH;VLPQDAQTLGPRAYVCACCEGP;VPALYSSDPAARER 10 10.8 1.0015 -2.6584 6.15965 9.12637 9.09191 0 8.34372 0 8.45771 10.2382 10.7445 0 0 0 0 0 0 A0A8C0TMB3 A0A8C0TMB3_CANLF Calponin-homology (CH) domain-containing protein LIMCH1 Canis lupus familiaris (Dog) (Canis familiaris) DSESDLPH;EQERLLQERYQKEQ;LPHRKLPD;PAGQVQPGG;PGAAGFPLRVQNSWR;PGGPTAAPAPQ;PSAPGSPGAAGFPLRVQ;QEQERLLQERYQKE;QEQERLLQERYQKEQNKLKEEWEK 9 5.7 1.0036 -1.6009 10.0285 11.8805 12.9777 0 0 10.2281 12.4762 12.5983 8.87264 0 0 0 0 0 12.9065 A0A8C0TMC4 A0A8C0TMC4_CANLF Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) ADA Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] anchoring junction [GO:0070161]; cytoplasmic vesicle lumen [GO:0060205]; plasma membrane [GO:0005886] adenosine deaminase activity [GO:0004000] DIICMDKPLSL;GAGRGGPCPGLVKRIVARRG;LPAETVEELQDI 3 9.2 0.61233 0.35443 4.97939 0 0 0 0 0 13.7229 13.554 14.2916 0 0 0 0 4.98331 10.2508 A0A8C0TMC7 A0A8C0TMC7_CANLF Lebercilin-like protein (Leber congenital amaurosis 5-like protein) Canis lupus familiaris (Dog) (Canis familiaris) AASIKAPLRPRKHYSFT;AQGKFTGSLQINDTDETPDKTA;DYSRSQCSCRSLSSCCD 3 8.4 0.87855 0.1396 5.00917 0 8.22617 0 0 0 0 0 0 0 0 4.52494 6.00955 0 0 A0A8C0TMD2 A0A8C0TMD2_CANLF Shisa N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] STSRGSSSRQSST 1 4.6 0.9389 0.059769 0 0 0 0 0 0 0 0 0 0 8.75014 0 0 0 0 A0A8C0TMD9 A0A8C0TMD9_CANLF Keratin 1 KRT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] DEINKRTNAENEF;EGEESRMSGECAPNV;GGFGLGGG;GGGGGGGA;NAENEFVTIK;QISETNVILSMDNNR;SGGRGSSS;VGGGGGYGG;YGSGGGGG 9 16.3 1.0026 -2.1741 0 8.58353 0 0 0 6.87885 0 0 0 0 0 0 0 0 0 A0A8C0TME1 A0A8C0TME1_CANLF Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; muscle contraction [GO:0006936] actin filament [GO:0005884] actin filament binding [GO:0051015] IDDLEDKFLCFTPP;LQKLEEAEKAADESERGM;PETPSSSWLSHLSEL;QEIQLKEAKH;RAEFAERSVTKLEKSIDDLEDK;RETAEADVASL 6 17.2 0.99447 -0.026515 0 0 0 0 0 0 0 6.09923 0 0 10.7065 0 7.08799 0 6.07421 A0A8C0TMF0 A0A8C0TMF0_CANLF Cilia and flagella associated protein 44 CFAP44 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement [GO:0003341] cell projection [GO:0042995]; cytoplasm [GO:0005737] AGFQAAIGENNKF;ANFLMKVLKKRIKRVKK;ASGAIWKLDLSFS;EDSDESSEEESSLESGEDESG;EELKIRKIRKELLNAKEMKMWEEKI;ENNKFANFLMKVLKKRIKRVKKKE;ESGEDESGSDDEVFDDS;FFYDYMELVLM;KAGKREKLKALRNEFWKL;LKKRIKRVKKKE;LMKVLKKRIKRVKKK;MIKMNEIGSNFWLAQD;PDGKVLSGSEWGNML;SYLEDDDYSM;TAFKIHQVEKELAWE;VLKKRIKRVKKK;VLKKRIKRVKKKEV;WELMMKTKEHT;YPEEVPEKRFQYDEEI 19 11.5 1.002 -1.4528 8.57792 9.07887 3.75243 4.76776 6.66448 9.5919 8.16611 10.948 10.4851 0 9.12866 0 6.84499 0 8.82404 A0A8C0TMF1 A0A8C0TMF1_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AHGGQGVG;VGVGPCPD 2 4 1.0033 -2.2088 0 0 9.01117 0 0 7.59991 0 10.2574 0 0 0 0 0 0 0 A0A8C0TMG8 A0A8C0TMG8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LNPFIYSLRNRDLKGALRKLFSKKI;WVFSYFISL 2 11 1.0022 -0.76868 7.67723 0 0 0 0 0 0 0 0 0 0 0 0 0 9.88696 A0A8C0TMI7 A0A8C0TMI7_CANLF Keratin-associated protein LOC100686358 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] PGSVGLGSRSC 1 6.8 0.99455 -0.15528 0 0 0 0 0 0 0 0 0 0 12.1936 0 0 0 0 A0A8C0TMJ2 A0A8C0TMJ2_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] CGTNAFSP;CSSNCGGG;GPHCTRSPQPGA;GSGASWSAGTAARAQLRGAA;KQQRCSTLEDSSNMS;RCGGRDCLGPAIHIANCSRNGA;YPSPLNKHSFRPE 7 7.6 1.0028 -0.84848 0 0 0 0 0 0 0 0 0 0 8.82161 0 0 0 0 A0A8C0TMK3 A0A8C0TMK3_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) axonemal microtubule [GO:0005879] calcium ion binding [GO:0005509] EAENTEPGVEPPDRIRP;GVIDKAELREACEQVSL;LLIKPEDIVL;NFDTLLAAFRHY;THGIRSRI 5 7.7 1.0021 -1.8241 0 0 9.65907 7.31895 0 0 9.55622 0 0 0 0 0 7.77162 10.9556 3.06198 A0A8C0TMK5 A0A8C0TMK5_CANLF Trophinin Canis lupus familiaris (Dog) (Canis familiaris) FDGVLSTSVPFGG;GGTLNTSFCFGGSPST 2 7.8 0.99483 -0.15234 0 0 0 0 8.61309 0 0 13.3242 0 0 0 0 0 0 10.7687 A0A8C0TML4 A0A8C0TML4_CANLF H/ACA ribonucleoprotein complex subunit DKC1 (Dyskerin) DKC1 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522]; RNA processing [GO:0006396] Cajal body [GO:0015030] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] ARKKKKKKKIKA;ARKKKKKKKIKAE;EVVAKAGTAAQEVTEVVK;IALMTTAVISTCDH;KRDSESDELSPQLLKKE;NLLSLVVLILPKKH;PLTELSGPWGE;PQLLKKEKKKKKKEKAKA;QWPLLLKNFDKLNV;RKKKKKKKI;SKMIEYDPERRL;SLVVLILPKKHKKK;SLVVLILPKKHKKKKERKSLPE;YSDSAKKEVVAKAG 14 20.8 0.98622 -0.41662 9.10533 0 9.0112 5.73547 7.28142 4.99887 9.27726 9.37323 5.71238 0 8.18393 0 10.8244 9.09937 0 A0A8C0TMM1 A0A8C0TMM1_CANLF Cyclin N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] RAWARAGRSRRRRRRRRRRPP 1 3.6 0.97554 0.047166 0 0 0 0 0 0 0 0 0 6.53706 0 0 0 0 0 A0A8C0TMM7 A0A8C0TMM7_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] AEAAMNWVMSHMDDPD;ALLSADSASRKQE;LDISQLRGTGLQPGEE;RRPKEEDTTTGTGDPPRKK;SLGFYGNEDEDSFCSPHFSS;STSAAADPPPEDCV;YLNSVVQVLF 7 12.6 1.0036 -1.0695 12.877 12.6766 0 11.9757 0 11.8261 8.93578 0 0 0 0 12.7996 12.7036 0 0 A0A8C0TMN0 A0A8C0TMN0_CANLF Zinc finger protein 75D Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HWRMASELILPEYQSLLTFEDVAV;KPAEPQPLGVFQKE;PQEQLGWNTHRESQPVYQR 3 11.2 0.99028 -0.53426 0 0 8.46082 7.2651 0 8.24627 0 0 0 0 0 0 0 0 0 A0A8C0TMR5 A0A8C0TMR5_CANLF CS domain-containing protein NUDCD3 Canis lupus familiaris (Dog) (Canis familiaris) AGACWGHG 1 2 1.0037 -1.1044 0 0 0 0 0 6.11792 0 0 0 0 0 0 0 0 0 A0A8C0TMR9 A0A8C0TMR9_CANLF Rab-GAP TBC domain-containing protein TBC1D5 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] AEVPRHHLQQQQQQ;IVFILHCDHQAFL;QEWFLSLRRK;SESAQPSEEMKTLL;SLRFNQSQ;TISDDHYC;TISDDHYCSSG;WEELFVNNN 8 9.3 0.99893 -2.938 0 10.6274 0 0 0 0 0 8.99642 0 3.46923 0 9.98613 0 0 9.63867 A0A8C0TMT3 A0A8C0TMT3_CANLF YTH domain-containing family protein YTHDC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] EEEEEEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEEEEEEEEEEEEYEQ;EEEEEEEEEEEEEEEEEEEEEYEQD;EEEEEEEEEEEEEEEEEYEQDERDQ;EEEEEEEEEEEEEEYEQDERDQKEE;EEEEEEEEEEEEEYEQDERDQKEEG;EEEEEEYEQ;EEEYEQDERDQKEEGNDYDTRS;GEEEEEEEEEEEEEEEEEEE;RSKRLEADRKIRLS;SQSSKEEVNSEEYG;VLPAGMNA;VPEQDDELYNP;YSGHHPVPHEARYRDKRVHDYDMR 14 16.2 0.98745 -0.40591 2.75982 11.5777 8.69596 4.28681 7.7185 5.98743 2.73253 7.45096 0 8.12516 3.41197 0 9.78772 8.4297 0 A0A8C0TMU7 A0A8C0TMU7_CANLF SUMO specific peptidase 7 SENP7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] HVITNENESASESA;HYYCASTCSFPAAAAEEM;IAKPTYTFLQ;KTSPERIPRVILTN;PERIPRVILT;SLNEVSLLVDTTHL;VICFPWLEE;VNESSHWYLAVICFPWLEEAIY 8 9.4 1.0034 -1.6883 11.1946 10.8532 0 8.66633 9.66272 9.44743 10.2155 10.9831 10.4339 10.6115 10.7576 11.0534 0 10.7868 11.1632 A0A8C0TMU9 A0A8C0TMU9_CANLF Methyltransferase type 11 domain-containing protein ECE2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] QDSDHEDFL;TLRWETMDVRALDFPS 2 9.8 0.99446 -0.024531 8.8715 0 0 9.79844 9.39457 0 9.76237 10.4808 0 9.96459 0 10.2807 0 0 0 A0A8C0TMV6 A0A8C0TMV6_CANLF Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) BCAT1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid biosynthetic process [GO:0008652]; branched-chain amino acid biosynthetic process [GO:0009082] branched-chain-amino-acid transaminase activity [GO:0004084] ESVNLGEFKVSERYLTMDDLTT;ESVNLGEFKVSERYLTMDDLTTALE;GVKKPTKALLFVI;LKEKPDPNALVFG;MNLFLYWI 5 15.5 0.99369 -0.054297 7.85175 0 0 9.20841 9.02031 0 8.19786 0 0 0 0 6.15619 9.18003 0 0 A0A8C0TMW4 A0A8C0TMW4_CANLF Vav guanine nucleotide exchange factor 1 VAV1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] DQIDDTVEEDEDLYDCVEN;KYTDTLGSIQQHFMKPLQ;SPIDFSGTMKKDKPHRRAQDKKR;TEPMPMPPKMTEYDKRCC 4 8.9 0.97717 0.046343 0 0 0 0 0 0 0 0 5.39211 0 0 0 0 0 0 A0A8C0TMW6 A0A8C0TMW6_CANLF tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (NOL1/NOP2/Sun domain family member 2) (mRNA cytosine C(5)-methyltransferase) (tRNA cytosine C(5)-methyltransferase) Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] extracellular region [GO:0005576]; nucleus [GO:0005634] tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049] EWEDVPHSRHTQIRPTMFPPKDPE;FVFIPEDDPLFPPIQ;VGAGARAG;WEDVPHSRHTQI 4 4.8 0.9935 -0.12027 0 0 11.2351 9.80433 10.6972 0 0 11.0034 7.7224 10.3234 10.2245 10.6667 10.5436 10.2569 10.7549 A0A8C0TMX4 A0A8C0TMX4_CANLF Gremlin-1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] LNCPELQPP;TTMMVTLNCPELQP 2 10.5 1.0041 -1.1016 0 0 0 0 0 0 0 0 0 0 7.48953 0 0 0 0 A0A8C0TMY5 A0A8C0TMY5_CANLF TRASH domain-containing protein ZMYM2 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CYLSKSPQNLNQRMDVFYLQ;DDSSDNSECTFPFK;IEPVQPPPP;IMNCCEQC;KMTGSAPPPSPTPNK;SLDRNTLE;SPVASLPKQIFQPSA;TYCKPHMQTKSCQTDDNW;VFQNGESATHHNP 9 10.2 1.0031 -2.1088 8.63778 7.90466 6.91767 9.30795 8.9808 0 11.2281 0 0 0 0 10.4775 5.62997 0 10.7489 A0A8C0TMY9 A0A8C0TMY9_CANLF LIM domain kinase 2 (EC 2.7.11.1) LIMK2 Canis lupus familiaris (Dog) (Canis familiaris) spindle [GO:0005819] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] YSVTHISMPATA 1 1.9 0.95282 0.05044 0 0 0 0 0 0 9.4559 0 0 0 0 0 0 0 0 A0A8C0TN11 A0A8C0TN11_CANLF Tensin 1 Canis lupus familiaris (Dog) (Canis familiaris) HYFSGLLSGSIKM;LVSQERDRG;PSTANEENFRS 3 7.9 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 9.70665 0 0 A0A8C0TN36 A0A8C0TN36_CANLF Insulin like growth factor 2 receptor IGF2R Canis lupus familiaris (Dog) (Canis familiaris) lysosomal transport [GO:0007041] late endosome [GO:0005770]; plasma membrane [GO:0005886] D-mannose binding [GO:0005537]; insulin-like growth factor binding [GO:0005520]; signaling receptor activity [GO:0038023] AKKEVPCYAFDGELKKH;FSRKVGTSDKT;GEMDCTYF;GKPRPVPQKTGT;GVPCPAGAAVCKVPVDGPPID;IFFYCDRSTQRPVFL;IFKCDEDADIGRPQ;IHRTGGYEAYDES;KEEEADENETEW;LDEGGCKDGGVCLL;LSPQAGSEPCPPEAAACLLS;LSSLARYSD;NEVYLNFESSTPCLAD;PWNLGVSNAKLSYYD;QIRKKSTTIRFTCSESQVNSRP;RGKPRPVPQKT;SICEDNENCSP;VDTSVDGRKRTFY;VGHPEYQEEDNSTYNFR;VTITFVCPSE;YINLCQKIYKGPLDCSDRASICKKS 21 12.1 0.99836 -3.2867 10.5991 0 12.4124 9.14114 4.54449 5.29245 18.8406 6.44263 12.3717 0 8.25894 8.3565 9.53253 9.43605 0 A0A8C0TN41 A0A8C0TN41_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GRHHFPGPCPSRLELVEAWFSPHPH;SFLWTWGA 2 13.4 1.0038 -1.0689 0 0 0 0 0 0 7.7137 0 0 0 0 0 0 9.66523 0 A0A8C0TN51 A0A8C0TN51_CANLF Fibroblast growth factor 23 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; type 1 fibroblast growth factor receptor binding [GO:0005105] KRAFLPAP 1 4.2 0.98963 -0.26527 0 13.1171 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TN63 A0A8C0TN63_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PASK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAEGLPMPYPGYGGEQSTQ;EDQRDIPGRSPP;GLWLLQRGHQPQ;ILVANDKACQLLGHSSHA;IPGRSPPAHNQQ;VGGLWLLQ;VLMGNPRPHAPAL;WMFASQGG 8 6.6 1.0024 -2.5826 8.94254 9.6934 0 0 0 0 0 0 0 0 0 7.57758 8.18254 0 0 A0A8C0TN69 A0A8C0TN69_CANLF Nucleolar protein 10 NOP10 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522]; rRNA processing [GO:0006364] ribonucleoprotein complex [GO:1990904] snoRNA binding [GO:0030515] ITVKKRFKVL;TLKKLDPMGQQTCSAHPARFSP 2 50 0.99138 -0.27613 0 9.65118 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TN71 A0A8C0TN71_CANLF Elongation factor 1-gamma Canis lupus familiaris (Dog) (Canis familiaris) translational elongation [GO:0006414] cytoplasm [GO:0005737]; nucleus [GO:0005634] AFEGDDGFCVFESNAIAYYV;DGNLGQRKTLVGIWNQFWS;HRKRRVLGKRSRSPRLRGKRRRLL 3 23.9 0.97353 0.041303 0 0 0 0 0 0 0 6.37396 0 0 0 0 0 0 0 A0A8C0TN75 A0A8C0TN75_CANLF Palmitoyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] palmitoyltransferase activity [GO:0016409] GFLRNWHQFSTLG;GVKPGKKNKAE;TLGAPPFHHPAEDI 3 9.4 1.0036 -0.80275 0 8.31102 10.07 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TN85 A0A8C0TN85_CANLF GRF-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EIEEYNDTL;GLYLRSQNIPLFEECQ;HIEVEPAGESKQHWNS;KLTSACMQIDFLQFPD;LPSKSKGISS;NFETSDSEEESQENN;NKGRLFYTC;NNEDANKSIQK;RQEYSGSS;TDPENSVIYKNREKNG;THQKMKKS;VCNASTELTTL 12 6.9 1.003 -2.5525 0 0 0 11.0338 9.38955 0 9.82291 9.52933 11.041 9.73227 9.04914 7.63684 8.83779 8.72588 3.81506 A0A8C0TN86 A0A8C0TN86_CANLF Potassium voltage-gated channel subfamily C member 1 KCNC1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] ADADGPGDSGDGED;ADADGPGDSGDGEDELEMT;INRAVGLLDHL;LDNSADDADAD;LTIAMPVPVIV;VVRFVRILRIFKLTRHFV;WALFEDPYSSRYARYVAFASLFFIL 7 17.1 0.99234 -0.19237 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0496 A0A8C0TN87 A0A8C0TN87_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MID2 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to microtubule [GO:0035372] cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] ESSLKKSHT;MSSERIACQFCEQDPPRDA;VLRFSKMSFSCSCRKLL 3 6.3 0.98738 -0.50121 0 10.0467 10.0757 0 0 0 0 11.8907 0 0 0 0 0 0 0 A0A8C0TN98 A0A8C0TN98_CANLF Attractin like 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APPALRLRLRLRLRPGP;DISQQKPSDSKDKTS;GGGGGGGA;GHSTCINNNVCEQC;IEGYPNAVLRLRF;LDEIQKYTQQ;QSWSTKTPTVL;RPGARWPPARRCGTEP;TAGTISGEETPI;VRGGGGGG;WSFIQCPACQCN 11 8.1 1.0028 -0.77931 13.7903 13.7249 0 0 0 10.2477 8.01028 10.2234 0 5.90747 5.17145 0 13.2794 8.39579 8.85587 A0A8C0TNA0 A0A8C0TNA0_CANLF Solute carrier family 24 member 3 SLC24A3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane transport [GO:0070588] membrane [GO:0016020] antiporter activity [GO:0015297] AGLRIMIT;DVVAEAGNETENENEDNENNEND;EAGNETENENEDNENNENDEEEE;EDNENNENDEEEEEDEDDD;EEEEEDEDDDEG;ENENEDNENNENDEEEEEDEDD;IVARQGMGDMAV;LAFAGFPELV;LHLSEDVAGATFMAAG;NEDNENNENDEEEEEDEDDDEGP;TWPLSFVLYFT;VTFASSTLWIAAF 12 16.2 1.0024 -0.97283 0 10.0909 9.19212 3.77589 4.92643 0 10.0211 9.53669 6.12943 11.5221 0 5.14041 0 0 10.1182 A0A8C0TNA7 A0A8C0TNA7_CANLF Family with sequence similarity 222 member A Canis lupus familiaris (Dog) (Canis familiaris) APYPAPSTLGPLGY;GMAYTAAATGLPDCR;NLPSIHSILYQLNQ;PAACQAVA;PDCRKGAELGQGS 5 13.2 1.0019 -1.3652 8.47602 9.36481 0 0 0 0 0 8.56274 0 0 0 0 7.85935 0 0 A0A8C0TNA9 A0A8C0TNA9_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 10 ADAMTS10 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EVCSELWCLSKSN;GVSSSSRHCDSPRP;NRGGGAVG;NRSGHGNAIPEN;TLGLAPVGGMCER 5 5.3 1.0027 -1.7767 0 0 0 0 8.65632 0 0 9.40825 10.8479 14.4118 0 0 0 0 0 A0A8C0TNB1 A0A8C0TNB1_CANLF DUF4200 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; intracellular non-membrane-bounded organelle [GO:0043232] VLHLLEKRRE 1 3.3 0.98872 -0.26445 0 8.60199 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TNB5 A0A8C0TNB5_CANLF PH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EQWLRVIQEVSGLPSE;LPWFNRDYT;QVRKKEHKLKITP 3 4.4 1.002 -0.90988 0 0 0 0 0 0 0 0 0 0 0 0 9.23153 0 0 A0A8C0TNC8 A0A8C0TNC8_CANLF Transmembrane protease serine Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ALLREKILSILNQKI;IKNQVVRLTPEED;LFFFLNFFNFIYLFMIFTQRERERE;PVNASSVQ;WMIALLAVLLLTVVAVTIGLL 5 17 1.0025 -1.1759 5.93161 0 6.46269 0 0 5.57289 0 0 0 0 0 0 0 9.75424 0 A0A8C0TND0 A0A8C0TND0_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] KKRPIPNPT;KQPMMVYVGTL;VESKATSS 3 6.3 1.0031 -2.1444 0 0 9.42331 0 0 0 0 0 0 9.10949 0 0 0 8.62739 0 A0A8C0TNE5 A0A8C0TNE5_CANLF Keratin 71 KRT71 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] SVRDVVEDYKKRYEEEI 1 3.2 0.98424 0.046227 0 0 0 0 0 0 0 0 0 0 9.02067 0 0 0 0 A0A8C0TNF6 A0A8C0TNF6_CANLF Heparan-sulfate 6-O-sulfotransferase (EC 2.8.2.-) HS6ST2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sulfotransferase activity [GO:0008146] KIFGPLASV;LDAARNFHYI;LDAARNFHYITILRD;LQRYQFMRQKEHQEARQKRQEQRKF;MRQKEHQE 5 7.9 1.0031 -0.97569 0 0 0 0 0 9.75019 0 7.13791 0 10.5271 5.58427 5.32362 0 9.63181 0 A0A8C0TNG3 A0A8C0TNG3_CANLF Amine oxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on NAD(P)H [GO:0016651]" AQGPAGGRW;GAQYITRSPQRAGP;LPLRTRGWPRLPGPRPLPGPR 3 6.3 0.9898 -0.20469 0 0 0 0 0 0 9.45541 0 5.49156 0 0 0 0 0 0 A0A8C0TNI5 A0A8C0TNI5_CANLF "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (Slo-alpha) (Slo1) (Slowpoke homolog)" KCNMA1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; voltage-gated potassium channel complex [GO:0008076] actin binding [GO:0003779]; large conductance calcium-activated potassium channel activity [GO:0060072]; voltage-gated potassium channel activity [GO:0005249] DSTGMFHWCAPKE;ESRDKQNATRMNRM;FIILLWRTLKYLWT;GGGGGGGG;GGGGGGSG;INQYKSTSSLI;LPGTPLSRADLRA;SFRAFEDEQP;TDLIFCLM 9 7.6 1.002 -1.4354 0 9.0631 0 0 7.31334 0 5.98087 0 0 0 0 0 7.89069 0 10.1809 A0A8C0TNI8 A0A8C0TNI8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] AEDTAMYYC;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;SVLAWVFLIAILKGV;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLQ 27 36.7 1.0016 -0.75034 0 0 0 0 0 3.36093 5.5809 0 0 0 0 0 0 0 0 A0A8C0TNJ9 A0A8C0TNJ9_CANLF M-phase inducer phosphatase (EC 3.1.3.48) CDC25A Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; positive regulation of cell cycle G2/M phase transition [GO:1902751] protein tyrosine phosphatase activity [GO:0004725] KGTIENILDNDPRDL;LGPAAHPS;LGSEYEQALEVRNSSLQ 3 7.4 0.98956 -0.26566 0 0 0 0 0 0 0 0 0 0 7.00518 0 0 0 0 A0A8C0TNK8 A0A8C0TNK8_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" SMARCD1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SWI/SNF complex [GO:0016514] transcription coregulator activity [GO:0003712] DPGPRCGIIS;QEALKRPIKQKRKLRIF 2 11.2 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 8.62198 0 0 0 A0A8C0TNN2 A0A8C0TNN2_CANLF BCL2 like 14 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] DGEDQIIAKIVELLK;LVMCTTSSCDLEE 2 8.5 0.98939 -0.20447 0 0 0 0 0 0 0 0 0 8.27603 0 0 0 0 0 A0A8C0TNN4 A0A8C0TNN4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCSQSCCCKPCCSQSCCC;CCSQSCCCKPCCSQSCCCKPCCS;CGSSCCQSSCCKPCCCESSC;CQSSCCKPCCCE;CVPACPCSSCGSCGG;CYKPCCCESSCCKPCCCQS;ESSCCKPCCCQSSCCKPCCCESSC;GCGSSCCQSSCCKPCCCESSCCKP;GCGSSCCQSSCCKPCCCESSCCKPC;GGCGSCGGS;GGCGSSCC;KPCCCESSCCKPCCCQ;PCCCESSCCKPCC;PCCCESSCCKPCCCQ;PCCCESSCCKPCCSQSCCC;PCCCQSSCCKPCCCE;PCCSQSCCYKPCCCESSCCKPC;PVCCCVPACPCSSCG;SCCCKPCCSQSCCCK;SCCKPCCCESSCCKPCCSQSCCC;SCCYKPCCCESSCCKPCCC;SCCYKPCCCESSCCKPCCCQSS;SQSSCCKPCCCESSCCKPCCSQ;SSCCKPCCCESSCC;SSCCKPCCSQSCCCKPCCSQSSCC 25 79.1 0.87384 0.14281 10.0291 5.87801 0 0 0 6.3274 0 0 0 0 0 0 0 0 0 A0A8C0TNP1 A0A8C0TNP1_CANLF DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (Deoxycytidine deaminase) Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087] nucleus [GO:0005634]; P-body [GO:0000932] hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] GAPAQPCP;QTFVDHQDSPFQPW 2 11 0.99677 -0.58895 0 0 0 0 0 0 0 0 10.931 0 0 0 0 0 0 A0A8C0TNP2 A0A8C0TNP2_CANLF Collagen type XX alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] ASFQLQMLQIVCNDSWADEDVCCE;CPDPEPLG;EVMLTTKTPKATVGGLSP;EVVVDGPTLSAE;GARGTAGE;IVCNDSWADEDVCC;IVCNDSWADEDVCCE;LPEDRLQMKWRESDGSS;VGKAGVGEGLRGLVTTAPLPP 9 8.5 0.97643 0.046227 0 6.07662 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TNQ2 A0A8C0TNQ2_CANLF Tubulin alpha chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] DEIRNGPYRQLFHPE;DIERPTYTNL;DVVPKDVNAAIA;GDVVPKDVNAAIA;GPYRQLFHPEQLITGKEDA;THTTLEHSDC;TIGKEIIDPVL;TVVPGGDLAKVQ;VISAEKAYHEQLSV 9 22.4 0.85362 0.14965 10.4552 0 10.3886 0 0 0 9.43956 5.5386 10.765 0 8.67959 0 0 0 0 A0A8C0TNQ6 A0A8C0TNQ6_CANLF Roundabout guidance receptor 2 ROBO2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFSQSVSNSWQ;GVASSPAISFGQQSTATLT;IVSKGEPTTLNCKAE;KGSTGPRKAEALRGSHQRNASD;MVRAINPQGLSD;PDDDADDEEE 6 6.5 0.98765 -0.39973 14.1346 0 14.1588 0 12.92 0 10.3847 0 8.54578 9.44909 0 0 13.6815 13.6639 0 A0A8C0TNR3 A0A8C0TNR3_CANLF Olfactory receptor OR51AJ4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] APMYFFLSMLAATD;APMYFFLSMLAATDLG;MGYVYLLIPPVLNPVVY;VGLLLRAVAVILPGPFLIKR;VGLLLRAVAVILPGPFLIKRL;VHIIMGYVYL 6 18.1 0.99266 -0.19383 0 10.6263 10.0828 13.0078 13.2323 0 14.1289 11.3954 0 11.5766 6.85773 11.6998 12.6782 10.7252 11.0978 A0A8C0TNU9 A0A8C0TNU9_CANLF Olfactory receptor family 51 subfamily AB member 4 OR51AB4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISLAVLHRYSRD;VIAGEWFFF 2 6.4 1.0015 -0.75377 0 0 0 9.54637 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TNW0 A0A8C0TNW0_CANLF Glypican-3 GPC3 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of protein localization to membrane [GO:1905475] cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] CGDDEDECIGGSGDGT;FQGAHAVKLLPQVSSVSCPN;GLESGDCGDDEDEC;LDEEGLESGDCGDDEDECIGG;VPETPVPGS 5 9 0.98847 -0.2274 0 0 4.58093 0 0 0 0 0 10.2971 0 0 0 0 0 0 A0A8C0TNW2 A0A8C0TNW2_CANLF Sodium/calcium exchanger membrane region domain-containing protein SLC24A5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane transport [GO:0070588] membrane [GO:0016020] antiporter activity [GO:0015297] DGGIVIYFLIILY;EERSEQQPLMGWED;GVFITKGDI;LTTPDCRRKFWKNYFMITFFMSAL;SAPELVTAFLGVFI 5 14.3 0.98635 -0.42144 6.67934 0 0 0 0 0 14.1952 0 0 3.83279 0 0 0 0 9.21648 A0A8C0TNW3 A0A8C0TNW3_CANLF A-kinase anchor 110kDa C-terminal domain-containing protein AKAP3 Canis lupus familiaris (Dog) (Canis familiaris) motile cilium [GO:0031514] AGDDEGIQE;GGDQEEAEKKDLMS;GVCKVDVYSP;KVPEQPIKEEYSH;RKEINERIDGSENRCIHQSL;SPQMGGDQEE;WVAASELNVPILY 7 9.7 1.0024 -1.0006 8.84134 9.39808 0 0 0 9.1482 8.01759 0 0 0 0 0 0 0 13.2355 A0A8C0TP00 A0A8C0TP00_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SLK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AEVTEEVEDGKEEDDEEE;DGKEEDDEEETEN;DLNEKLTTDEPEK;EDTLTKEDTQEKL;FIGTPYWMAPE;KKQYEHVKRDLNPEEFW 6 6.5 0.98446 -0.25733 5.51362 11.0381 0 0 6.62653 0 0 0 0 0 0 4.07596 0 9.49921 0 A0A8C0TP13 A0A8C0TP13_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ELQSPQPDVRHRE 1 12.5 0.99193 -0.20811 0 0 0 8.23151 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TP35 A0A8C0TP35_CANLF Phosphatidylserine synthase (EC 2.7.8.29) (Serine-exchange enzyme) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylserine biosynthetic process [GO:0006659] endoplasmic reticulum membrane [GO:0005789] L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245] DEPPVKHHYWRAHT;FQTVQDGR;LPEPGDPP;LPPEHYLVLLRLVFFVNV 4 10.5 0.99435 -0.16334 0 0 0 0 0 0 0 0 0 0 0 0 11.3147 0 0 A0A8C0TP58 A0A8C0TP58_CANLF Zinc finger protein 512 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] PVSTDYFP 1 3.4 0.98498 -0.25934 0 0 9.57633 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TP68 A0A8C0TP68_CANLF C2 domain-containing protein TNNI2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPYARVSLSTQAGHRH;DTPPTGLPWFLR;QHWADMLAH;VAVAAGVL 4 9.1 1.0033 -0.80421 0 0 0 0 0 0 5.60407 0 0 0 0 0 0 0 0 A0A8C0TP84 A0A8C0TP84_CANLF Transmembrane protease serine (EC 3.4.21.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] DISVAELSSPV;HYVRYNQRKTYNYYGTLSFTSNKL;INSTWLVSAAH;LVSPDARDIWYLAG;SFGVTIPP 5 16.2 1.0022 -1.3606 11.4911 0 0 0 0 0 9.74204 9.08454 0 0 9.67795 10.2193 10.4808 0 0 A0A8C0TP89 A0A8C0TP89_CANLF ATP binding cassette subfamily B member 9 ABCB9 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LVTFMGFPIIMMVSDIYGKY;PQIQQAIHGNLQK;VVFMFSLSWQL;WALFVWTY 4 6.8 1.002 -1.2552 9.7684 0 0 0 0 0 8.56327 10.4818 0 0 0 0 0 0 11.8963 A0A8C0TPA6 A0A8C0TPA6_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR183 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142] EEERTTCMEY;FCTPLTDTKMDNL;KINSTTLYSTNL;LPWILLGACF;VLALVVIIQNRK;VNFMTCLSIDRFFAVVH 6 19.7 1.0016 -1.4102 0 0 6.87799 3.29628 0 0 0 0 0 0 0 7.69829 0 9.64389 0 A0A8C0TPC6 A0A8C0TPC6_CANLF Dipeptidase (EC 3.4.13.19) DPEP1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; side of membrane [GO:0098552] metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] AELLRRQWTEAEVRGVLANN;ASHTQLPSVTDCWNS;AVGFGGDF;DCWNSCPCSSL;EDVSKYPDLVAE;FILCKFSASHTQL;GAVGFGGD;SCNTPWADNWLVDTGEDKGE 8 17 0.99995 -2.8243 0 0 5.71342 0 7.92955 0 0 0 0 11.2572 0 0 0 12.187 7.19417 A0A8C0TPD4 A0A8C0TPD4_CANLF PR/SET domain 15 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AGTQFTNL;APEKEPEVPRGEPPA;HTVGKQWTCS;QKDGHPVCFDTSNEDDCNW;VQKYIHPCEV;WCEDCSQYHDSEC 6 6.6 1.0045 -2.013 0 9.94783 0 0 9.66035 0 6.97407 0 8.24003 0 0 0 0 0 4.00737 A0A8C0TPD7 A0A8C0TPD7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGTETRVSNHRI 1 3.4 0.98948 -0.26329 0 9.96607 0 0 0 0 10.3491 0 0 0 0 0 0 0 0 A0A8C0TPE5 A0A8C0TPE5_CANLF WASH complex subunit 3 (Coiled-coil domain-containing protein 53) Canis lupus familiaris (Dog) (Canis familiaris) WASH complex [GO:0071203] PVSVTGITNESHSEATS;SEGLDPDL;SEPFLNFLIFF 3 19.7 0.98633 -0.42846 0 0 0 0 0 0 0 0 5.71001 0 8.14614 0 0 0 0 A0A8C0TPE7 A0A8C0TPE7_CANLF endothelin-converting enzyme 1 (EC 3.4.24.71) ECE2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] Golgi apparatus [GO:0005794]; transport vesicle membrane [GO:0030658] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DSKSSNSNVIQVDQ;GGAGPGQG;GVSPCEDFY;TFNSTSEAERKTQ;WNITGPWDQDNFME 5 6.9 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 9.29923 0 0 0 0 A0A8C0TPG0 A0A8C0TPG0_CANLF C2 domain-containing protein DYSF Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] CAIILFIILFILLL;DIDLPYPPPQ;DSFRPSAGWTWAGD;EVQDMSGILEESEDI;FEGLSDFCNTFKL;FRCAIILFIILFILLLFLG;LPEDPAVPMPPRQFH;PAHEVLFSRRGASY;VSIGNYGNKFDTTC;WNQSITLPAMFPSMCEKMK;YDHDTYGADEFM;YLRRRKYSLFAAFY 12 8 1.0011 -0.94245 0 7.03045 5.57767 6.81096 11.576 0 10.2279 0 0 0 12.0748 6.60624 0 0 10.1908 A0A8C0TPG3 A0A8C0TPG3_CANLF NFKB inhibitor zeta NFKBIZ Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; POU domain binding [GO:0070974] PLPPQHYTPSP;VHHSESKQ 2 3 0.98882 -0.22386 0 0 0 0 8.72857 0 0 0 9.81205 0 0 0 0 0 0 A0A8C0TPJ0 A0A8C0TPJ0_CANLF Myeloid leukemia factor 2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] AEGPPRLAIQGPEDSPSR;EMRSAPGGIRETRRTVRDSD;PASRRMQAGAVSPFG;PFGMLGMSGGFMDMFGMMNDMIGNM 4 30.5 0.98511 -0.43114 5.93981 0 0 0 0 0 0 0 0 8.32396 0 9.87773 0 0 0 A0A8C0TPK8 A0A8C0TPK8_CANLF RAD51 interacting motif domain-containing protein RAD51AP1 Canis lupus familiaris (Dog) (Canis familiaris) EDFTMGRNKVKEMKKKEV;GVKKKKIH 2 6.5 0.98775 -0.46418 0 0 0 0 0 0 0 0 0 0 0 0 5.41687 10.4489 0 A0A8C0TPL7 A0A8C0TPL7_CANLF Aminopeptidase (EC 3.4.11.-) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] ELVHQWFGN;ETVKNNIEWLRQN;GVNQAEKDWQMR;ISAVTYIISMFEDDTELYPVI;NWEYLVNRYTINDRNLG;TELYPVIEEYFQSRV;VGFYRTTYEEN;VTVAEPFNTELQLWQME 8 11.3 1.004 -0.82475 0 0 0 7.37712 0 10.579 0 7.21985 10.3081 0 8.95029 10.3665 0 9.31338 0 A0A8C0TPL8 A0A8C0TPL8_CANLF Peroxisomal membrane protein PEX13 (Peroxin-13) PEX13 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]" peroxisomal membrane [GO:0005778] protein transmembrane transporter activity [GO:0008320] AEYDFAAV;ENEDLWAESE 2 4.5 0.99639 -0.57725 0 0 0 0 0 0 0 0 0 0 0 0 8.85767 0 0 A0A8C0TPN0 A0A8C0TPN0_CANLF C2H2-type domain-containing protein ZNF276 Canis lupus familiaris (Dog) (Canis familiaris) ALSPLPWEV;CDQGHDYTMDADSSCGAL;VHMSMVHPLTQTQDK 3 4.6 0.98947 -0.21414 0 0 0 0 13.0364 0 0 0 0 0 0 0 0 0 0 A0A8C0TPN1 A0A8C0TPN1_CANLF PABC domain-containing protein PABPC1L Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] LLLMLESP;REWRFLPSL 2 9.9 0.87793 0.12692 0 0 0 0 0 0 0 0 0 0 0 5.39053 10.4071 7.79701 0 A0A8C0TPN2 A0A8C0TPN2_CANLF [histone H4]-lysine(20) N-methyltransferase (EC 2.1.1.361) KMT5A Canis lupus familiaris (Dog) (Canis familiaris) "methylation [GO:0032259]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]" nucleus [GO:0005634]; polytene chromosome [GO:0005700] histone H4K20 methyltransferase activity [GO:0042799] DPSTGCYM;GGGGGGGE;GGGGGGGG;TAIAKQALKKPIKGKQAPRKKAQ 4 8.3 1.0034 -1.0581 0 0 0 0 0 0 0 0 0 0 0 0 3.84469 0 7.99203 A0A8C0TPP8 A0A8C0TPP8_CANLF Hexosyltransferase (EC 2.4.1.-) Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] AYLKMRLMYVSLVVL;DKYPPFCSGTG;QRHRDIIQKDFVDAYF 3 13.3 0.98809 -0.49408 0 0 0 0 0 0 0 0 0 7.81044 0 0 8.49921 0 0 A0A8C0TPS2 A0A8C0TPS2_CANLF Zinc finger MYM-type containing 5 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DDDDDDDVV;EDDDDDDD;IMNCCEQC;LMKEDDDDDDDDVVFI;LPSKSAGNNVL;LTDTGNSFGDPSSLV;QPGVDFLSP;RDILVENDPPQVR 8 10.8 1.0031 -1.5151 0 0 0 0 0 8.60622 0 10.1306 0 0 0 0 0 0 8.64147 A0A8C0TPS5 A0A8C0TPS5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) LRRK2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; regulation of signal transduction [GO:0009966] cytosol [GO:0005829] ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein serine/threonine kinase activity [GO:0004674] ASGSCQGC;DIDALSQKCCISGHLEHLERLE;HVLHCLHSLAIPCN;IPCNNVEVLM;LSTEKHTSEEV;SLNFKILTVK 6 2.9 1.0034 -2.0868 9.19763 0 0 0 0 9.7879 0 0 6.35394 0 11.3359 0 0 7.01145 0 A0A8C0TPU2 A0A8C0TPU2_CANLF Zinc finger C3HC-type containing 1 LOC119873261 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] zinc ion binding [GO:0008270] PAFDFDRYKDRCAE;PSPDRFGMLPLGEP;TTSKLGSDIQ 3 7.4 1.0011 -0.62831 0 7.11249 0 0 0 0 0 0 7.64508 0 0 10.2321 0 0 0 A0A8C0TPV6 A0A8C0TPV6_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein ubiquitination [GO:0031398] metal ion binding [GO:0046872] GAREPGKG 1 2.9 1.0042 -1.1044 0 0 0 8.91328 9.38838 10.2068 0 0 0 0 0 0 0 0 0 A0A8C0TPV7 A0A8C0TPV7_CANLF Helicase C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] EAYSTGVL;IPFGVAYHHSGLTSDERKLLEEAYS;LGQRQNNDSEEDMFGDYDSFAENSF;YDMASCCDPDWMIYFR 4 7.5 0.97834 0.035538 0 0 0 0 0 0 0 0 8.47468 0 0 0 0 0 0 A0A8C0TPW3 A0A8C0TPW3_CANLF "Glutaryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.6)" GCDH Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] EILIRDTFRTYCQERLMPRILLA 1 5.5 0.97844 0.046273 0 0 0 0 0 0 0 0 0 7.17283 0 0 0 0 0 A0A8C0TPY1 A0A8C0TPY1_CANLF CRIB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; endomembrane system [GO:0012505] GKEGQHDVFGDISFLQ 1 7 0.93733 0.063755 0 9.51055 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TPY2 A0A8C0TPY2_CANLF Death domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ALDFLVGSGCDHSVKDKKGL;DRLYKREKDHPLRRE;LAVAARSNHTSLV;LTALHAAA;WLHGVAVASENP 5 12.2 0.99356 -0.026884 0 0 0 9.42671 0 0 0 0 0 0 0 0 0 0 10.1738 A0A8C0TQ19 A0A8C0TQ19_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) DUSP16 Canis lupus familiaris (Dog) (Canis familiaris) MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] KLKLLHLEKPNDPVPA;MIDAIIFTPAVFYCKAGGFA;NKELMQQNGIGYVL 3 7 0.98908 -0.30249 9.39285 0 0 0 0 0 0 0 10.9716 0 0 0 0 0 9.94689 A0A8C0TQ26 A0A8C0TQ26_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SPASPERRLDD 1 1.7 0.98164 0.035491 0 0 0 8.85702 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TQ33 A0A8C0TQ33_CANLF Palmitoyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659] palmitoyltransferase activity [GO:0016409] CNSCVARYDQHC;GCFGLVKPCAVDWTSQYTMV;TWFILFFPHLAGTP 3 7.4 0.86242 0.16069 0 8.42425 0 0 7.68384 0 0 0 0 0 0 0 0 0 8.87061 A0A8C0TQ38 A0A8C0TQ38_CANLF Solute carrier family 2 member 13 SLC2A13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GAGGGGGG;GGGGGGGD;GGGGGGGG;GVVSGAML;IVGCGLQMFQ;SATILQMSGVEDDRLAI;SDNDASDVE;SLQGAGGG;YSYCNECMLDPDCG 9 11.1 1.0042 -1.9963 8.05289 0 0 0 0 0 11.434 0 0 0 11.9253 0 0 0 11.223 A0A8C0TQ40 A0A8C0TQ40_CANLF Maestro heat like repeat family member 1 Canis lupus familiaris (Dog) (Canis familiaris) ESDCSNEE;IDDDSWLEQLIKV;IVKTCEPAILHRILNLVR;LSAQAVYSLYCILLLQKQ;NEVYSANVFYNNT;QHCCWDLLSCPRFY;TEQALVITGHLFF;TLISAKVV;VFCSISKQ;WGISGKNIEDIMEALQ 10 7.9 1.0031 -2.336 0 12.5156 0 10.163 5.09415 0 11.6654 0 10.2343 0 8.51483 0 8.801 0 0 A0A8C0TQ45 A0A8C0TQ45_CANLF LysM and putative peptidoglycan-binding domain-containing protein 2 Canis lupus familiaris (Dog) (Canis familiaris) AAAGASAAINRRL;AAPVRRKRRRRRRRRR;AERPAAAPVRRKRRRRRRR;EKPLSFNGLNSIDSP;PAAAPVRRKRRRRRRRR;PAAAPVRRKRRRRRRRRRRTRRRP;RKRRRRRRRRRRTRRRPLGE;TAAGEDLSPPSPQESD 8 15 0.84867 0.15597 9.93359 0 0 2.99503 0 0 0 0 11.2591 3.61412 0 5.71436 3.32524 0 0 A0A8C0TQ48 A0A8C0TQ48_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] EQLSQHEPKTPVAVAAAG;GADACTPPRVT;LVKKLLIIISRP;LVKKLLIIISRPARLL;SPLAHTPS;SSLNRSLSSSDSLP;TVDELHFL 7 4.8 1.0037 -1.0372 0 5.02388 10.3937 9.72538 0 0 0 0 11.6598 0 0 0 3.86433 0 7.4573 A0A8C0TQ58 A0A8C0TQ58_CANLF adenylate cyclase (EC 4.6.1.1) ADCY2 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] AAGGGGGG;AKMRASVRMTR;FKKLLRLFSLVIWICL;FKYYVTCACLIFFCIFI;GELVHMLNELF;GGGGGGGG;GVDINMRVGV;ISLPNHAKNCVKM;MLIMMVALVAYNTILLHTHA;PGSVCPAARR;SSCCPPGG;VIGAQKPQYDIWGNT 12 10.2 1.0028 -2.5662 4.66255 11.24 0 0 0 10.4962 0 0 6.8315 0 7.59574 0 13.1989 6.54764 9.09956 A0A8C0TQ93 A0A8C0TQ93_CANLF Extended synaptotagmin 3 ESYT3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] lipid binding [GO:0008289] DLQICYIGDCEIS;HYHLYLRLLTDLSSSLNP;LDAPGINEISDSL 3 4.9 0.97287 0.048313 0 0 6.15941 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TQD4 A0A8C0TQD4_CANLF Histone H2A Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] MPCRKATACLSIRPCANSCHHGS 1 11.3 0.97887 0.046276 0 0 0 0 0 6.94965 0 0 0 0 0 0 0 0 0 A0A8C0TQE6 A0A8C0TQE6_CANLF Protein kinase domain-containing protein BRSK2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321] EDLPPRNEIDP;FHMPHFIP;FQVDITYTEGG;GRLSKCGKNPSRSPGTPSLS;VLEHVSGGELF;WFGNFINLEK 6 10 1.002 -0.99915 0 10.3194 0 0 0 0 9.33427 0 0 8.38733 0 5.50516 0 0 0 A0A8C0TQE9 A0A8C0TQE9_CANLF Tyrosine specific protein phosphatases domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] DVWYSDEDAN;GKRSRHLNDQ;GRRSLSLPP;NSVEDSEDWSPN;QEQILLEDL;QRLTPTQK;RYLIDVEGWDPDTAIQ 7 13 0.99927 -2.9224 12.4292 10.9624 0 0 11.9556 0 10.8581 0 0 0 0 0 0 7.47403 0 A0A8C0TQH7 A0A8C0TQH7_CANLF Glutathione-dependent dehydroascorbate reductase (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Monomethylarsonic acid reductase) GSTO1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364] GLVPVLENSQGQLI;KIRRVLGLRGNFN;QEPGEGHEIININLKNKPEW;VEAGLGTTLLLRGVALRV 4 16.9 0.99757 -0.088839 0 3.82944 0 0 0 0 0 5.90304 13.8623 0 0 0 10.2312 0 0 A0A8C0TQJ5 A0A8C0TQJ5_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of skeletal muscle cell proliferation [GO:0014857]; skeletal muscle fiber development [GO:0048741] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEPVPFRETTQGPWESL;HYRLVMKRLGVVALTP;RRRQRALVQRLEPAPV 3 13 0.86512 0.14469 0 0 0 0 0 0 10.0348 0 0 4.66482 0 0 0 0 4.8383 A0A8C0TQN2 A0A8C0TQN2_CANLF Beta-secretase 2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta metabolic process [GO:0050435]; membrane protein ectodomain proteolysis [GO:0006509] endosome [GO:0005768]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] aspartic-type endopeptidase activity [GO:0004190] IILLILIVLLLL;IILLILIVLLLLP;IILLILIVLLLLPFRCRH;LARGAPALAAPLSV;SVCGIILLILIVLLLL;SYTLMSVCGI 6 6.4 1.0021 -0.99277 4.86992 4.39493 8.31238 4.18761 0 0 0 9.8831 9.13255 4.04282 9.79986 8.90011 6.19928 0 9.18762 A0A8C0TQQ4 A0A8C0TQQ4_CANLF Hook microtubule tethering protein 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705] cytoplasm [GO:0005737] microtubule binding [GO:0008017] DLELQRKREYI;LLKRKLEEHLQKLHE;PEQWPRHSL;QKLHEADLELQRKR;VQELQGQRQEEAMKAE 5 7.6 1.0026 -0.79939 0 0 0 0 0 0 0 10.2753 0 0 0 10.4235 8.45092 0 0 A0A8C0TQR9 A0A8C0TQR9_CANLF Regulator of telomere elongation helicase 1 (EC 3.6.4.12) RTEL1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723] nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872]" AIFLCDHRFAHV;DIPKIIYASRTHSQLTQ;DTAAQRQGPPAASAYL;DVRTALGSAGCSQL;EPRDTAAQRQGPPAASA;GAIFLCDHRFAHVDARAQLPSWV;HHRKGPRSDAWS;KTLCLLCSTLAW;LEALKPVF;PSTGAAPSTGPGSGPQEG;TVVIFDEAHNVE;VILLRLEAAID;VVAALPGP 13 11.7 0.99942 -3.0865 10.821 9.437 0 0 10.9225 11.8132 8.48103 7.89779 7.98806 0 11.3408 0 7.69592 10.1553 8.6606 A0A8C0TQS8 A0A8C0TQS8_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EIHDKSEELYIITSER;IAVPIIDSAIQGYNGTIFAYGQ;LEEMRSVTKERDDL;LESREKGE;NTHFDIEKLKNGIQ;QRNIFSLIQEKNELQRMLE;RIARMHVKEHQETIDKLRGLVS;SEKTDEIANM;SELEQLKEQL;TPVSFDET;VSETQEKICE 11 6.3 0.97321 0.046862 0 0 0 0 0 0 0 0 8.84574 0 0 0 0 0 0 A0A8C0TQT3 A0A8C0TQT3_CANLF Protein kinase domain-containing protein CDK10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] DSSYFKEKPLPCEPELMP;GVPISSLREITLLLRLRHPNIVELK;GVPLCGTCLWECPLGW;PWLSEAGLRLLNF 4 17.4 0.9903 -0.26728 0 0 0 0 0 0 0 0 0 0 0 0 0 11.034 0 A0A8C0TQU5 A0A8C0TQU5_CANLF Sorbin and SH3 domain containing 1 SORBS1 Canis lupus familiaris (Dog) (Canis familiaris) DDKEMRPARA;KAQTLKELPLQ;PITYVDVIKRPL;SASMKDSESPRHFIPADYL;SLSDPVSERRVGEQD;SPPPPLVPPIPEGLR;SPSPEISSELPGYLYS;VPSLPAAL 8 11.5 1.003 -0.87738 0 0 0 0 0 0 0 0 0 0 12.925 0 0 9.98783 0 A0A8C0TQV6 A0A8C0TQV6_CANLF Protein SDA1 LOC119865824 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055] nucleolus [GO:0005730] EEQQEIFKKLNGMPM;HCYPEHLSNFPQEL;IDNDEEPRGELLS;ISLDVMIELYR;KNNKVNIVLQN;LEKAMKVLKKQKKKKKPEVF;PHQREVTKILLFAAQASHHLVPPEI;VLDPDLRMTLYTH;VLKKQKKKK 9 18.8 1.0021 -1.247 8.10093 10.2904 9.81104 0 0 12.0294 9.41863 0 7.13175 5.217 1.62607 0 9.7726 0 10.2432 A0A8C0TQX5 A0A8C0TQX5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;RPRIVRGILKKKTISGG 5 4.7 0.97662 0.046227 0 0 0 3.91255 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TQY2 A0A8C0TQY2_CANLF Cyclin J Canis lupus familiaris (Dog) (Canis familiaris) mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] YLLDLFMDRY 1 2.6 0.98931 -0.26514 0 0 0 0 0 0 0 12.6224 0 0 0 0 0 0 0 A0A8C0TQY3 A0A8C0TQY3_CANLF ClpX-type ZB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270] DLANRSGE;SGCGACTCG 2 2.9 1.0029 -1.9086 9.08111 0 0 0 0 0 0 0 0 6.3401 0 0 0 0 0 A0A8C0TQY9 A0A8C0TQY9_CANLF Centrosomal protein 97 Canis lupus familiaris (Dog) (Canis familiaris) EEEKAFWTTNENSVQMKESVI;EISFLASLTEL;EQISSCAALQHLDLSD;LVPEHSSPVQD;PQAKDVRHEIRLR;VGINSNDDQLYAVKNNFPASAHNTR 6 12.3 1.0014 -0.94964 9.59585 0 0 0 0 0 0 0 12.9251 0 0 0 9.44754 0 8.28887 A0A8C0TQZ2 A0A8C0TQZ2_CANLF EGF-like domain-containing protein LRP6 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; chemical synaptic transmission [GO:0007268]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; Wnt signaling pathway involved in somitogenesis [GO:0090244] membrane [GO:0016020]; synapse [GO:0045202] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] ALTLFEDTLY;FYQCACPTGV;VHGPASVP;VPLGYVPHPSSLSGSLPVSETWEIN;WNECASSNGHCSHLCLAVPVGGFVC 5 5.2 0.97904 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 9.19096 0 A0A8C0TR30 A0A8C0TR30_CANLF Lymphocyte activating 3 LAG3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of regulatory T cell differentiation [GO:0045590]; plasmacytoid dendritic cell activation [GO:0002270]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576] MHC class II protein binding [GO:0042289]; transmembrane signaling receptor activity [GO:0004888] APVQLPCSPTIP;LEPEPELE;LSLLLILGILFLLLL;WEVQFLVLLLLQLLWVAPV 4 10.5 0.99244 -0.17519 5.47054 0 0 0 0 4.87843 0 0 0 0 0 0 0 0 0 A0A8C0TR35 A0A8C0TR35_CANLF WH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314] early endosome membrane [GO:0031901]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014] EVVDPSSGRAT;PEIDVPSYLPDLPG;VSLAQAKIEKIKGS 3 8.4 0.98696 -0.40713 9.27652 0 0 0 0 0 0 0 11.3617 0 0 0 10.8379 0 0 A0A8C0TR43 A0A8C0TR43_CANLF PKD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPEMESSI;GGGGGGGG;ISENPYSSGRI;KDIAVHEYFQSQLLS;PGGGGGGG;QTGGDGVG 6 4.4 1.0028 -2.1194 0 0 10.3241 7.78346 0 0 0 8.91961 7.59544 0 0 0 4.27419 0 0 A0A8C0TR47 A0A8C0TR47_CANLF Kinase non-catalytic C-lobe domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AELQSCSPGWCSAFYEADCFG;DQRRPQVE;EDPRDRPDLESI;EPATDTAQGSPCP;FLEDLYGPY;GLDAPCPAQPPRSKATE;LLTEYSTQQLCSQLTLLQQELFQKC;MARRSAQERPCPAE;NFEVGFRPQ;PLGLMAYLYSSDAFLEGYVQQFLYT;PPPSLSDV;PTGRPRTPTAA;SPLPRTACPSLQ;VGFRPQKS;VQDKYLLQ 15 10.8 0.99671 -4.2761 7.29416 0 0 8.77027 0 9.4849 9.14068 9.97728 10.5812 8.75027 9.95188 0 8.75669 10.1098 0 A0A8C0TR57 A0A8C0TR57_CANLF Upstream transcription factor family member 3 Canis lupus familiaris (Dog) (Canis familiaris) AEEIKKLRKQLEE;AGQLRERHHLYQLQHHVPHA;GTKGHMNPPVTTNMHGV;ISSAGNTQTTWTT;PLVTCAGLSQTSEQ;SDSSKIVDSSVELHPKQDLLLM;TEATPNEFNSQDSIEATVD;TTNHSRHVATGVN;VNSGGLNNRFGSILSPP 9 6.9 0.98886 -0.26227 13.392 5.12189 0 0 0 9.70027 9.53064 7.11624 13.5143 11.8195 11.1882 13.2304 13.0173 0 13.3383 A0A8C0TR75 A0A8C0TR75_CANLF Serine incorporator 3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LITLYTMYL;LLLYVWTLVA;QYSYFLFHFML 3 7 1.0018 -0.74235 0 0 0 0 0 0 11.7623 0 0 0 0 0 10.6752 12.1315 0 A0A8C0TR88 A0A8C0TR88_CANLF URB1 ribosome biogenesis homolog URB1 Canis lupus familiaris (Dog) (Canis familiaris) AAYYVLAAYYSHLEGAR;AMVMVTTAPLVC;DILRLLDRDRMM;EMWQGSGVYT;GPALLQLLL;TGTKQDADDVSIPISHIDGESIVVY;VQLFREALSKILPDLNTIV 7 4.9 1.0026 -1.1836 0 9.57491 0 0 7.47598 7.03672 0 11.0002 10.0463 0 0 0 3.07049 0 2.63756 A0A8C0TR98 A0A8C0TR98_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IPFFFFFFKSLLRFFFFFFFFFFFC 1 7.5 0.9798 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 8.85393 0 0 A0A8C0TR99 A0A8C0TR99_CANLF Sodium/hydrogen exchanger Canis lupus familiaris (Dog) (Canis familiaris) regulation of pH [GO:0006885] apical plasma membrane [GO:0016324]; early endosome membrane [GO:0031901]; recycling endosome membrane [GO:0055038] sodium:proton antiporter activity [GO:0015385] LLLVPLLVLGVLPR;SSRTRPSLSP 2 2.6 0.99382 -0.11835 0 0 0 0 0 0 0 0 0 0 4.94031 0 4.58081 0 0 A0A8C0TRB1 A0A8C0TRB1_CANLF poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; regulation of DNA repair [GO:0006282] poly(ADP-ribose) glycohydrolase activity [GO:0004649] ESEPSTVTLVPERFSNANVA;PVEDENGERTAGSR;SCQDSEADEETSPG;TSPGFDEQEDSNSSQ;VGLPLPVSL 5 7.3 1.003 -0.88331 0 3.24696 0 0 0 0 0 0 7.37252 13.1156 7.07168 0 0 0 0 A0A8C0TRC1 A0A8C0TRC1_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] NAD+ ADP-ribosyltransferase activity [GO:0003950] ADASKLPNLNELLQSSG;ADCDACMCQDF;EGDHYDYNTVPFNEDDPMSWTEDY;HGAVSLPG;LEPRTGFSSN;SIVRGRVS;TACDLTCPMGQVNADCDACMCQD;VGHCPVKTCAGQQ 8 7.2 0.98541 -0.25823 8.75889 0 0 0 0 0 0 10.5146 0 0 0 0 0 0 0 A0A8C0TRE7 A0A8C0TRE7_CANLF Double zinc ribbon and ankyrin repeat domains 1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] DLAAGELGPF;FKTKKFQEK;TVSSDNHVENGLK;TVSSDNHVENGLKDSSKQE 4 5.5 1.0031 -0.83757 0 0 0 0 0 0 0 0 9.17637 0 6.7343 11.4982 0 0 0 A0A8C0TRF6 A0A8C0TRF6_CANLF Family with sequence similarity 117 member B FAM117B Canis lupus familiaris (Dog) (Canis familiaris) EVSAAPPP;GGCCGGAS;GGGGGGGG;SAPVCKAG;SNGGGGGN 5 7.6 1.0009 -2.7335 0 0 8.53076 0 0 0 0 0 0 9.43688 8.30113 9.45065 0 0 0 A0A8C0TRH4 A0A8C0TRH4_CANLF Transcription initiation factor IIF subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; transcription initiation at RNA polymerase II promoter [GO:0006367] nucleus [GO:0005634] DNA binding [GO:0003677] DEAFEDSDDGDFEGQE;ESSEESEEEKPP;KKKKKKKGS;SSDDSEASGEEGGRAP 4 11.1 0.85 0.14891 0 0 5.19574 0 0 0 0 0 0 7.05691 0 0 6.43999 0 0 A0A8C0TRI3 A0A8C0TRI3_CANLF Outer mitochondrial transmembrane helix translocase ATAD1 Canis lupus familiaris (Dog) (Canis familiaris) extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570] mitochondrial outer membrane [GO:0005741]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AHLVDPLNMH;ESHDEDEI 2 5 1.002 -1.3649 0 0 0 0 7.96855 0 0 0 0 0 9.47362 0 0 0 0 A0A8C0TRL1 A0A8C0TRL1_CANLF Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.104) (EC 1.1.1.30) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (4-oxo-L-proline reductase) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) BDH2 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" ATAEEIALLCVYLAS;QELEKYPGIQTRTLDVTKKKQI 2 15.7 0.99353 -0.021649 0 0 0 0 8.79328 0 0 0 7.47411 0 10.7841 0 0 0 0 A0A8C0TRP1 A0A8C0TRP1_CANLF Nuclear coactivator domain-containing protein NCOA4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879] transcription coactivator activity [GO:0003713] SPRGSSRS;WLYEQVDLIYQLKEETLQ 2 4.2 1.0038 -1.1044 0 0 0 9.42164 9.53972 9.07799 0 0 0 0 0 0 0 0 0 A0A8C0TRP9 A0A8C0TRP9_CANLF SSD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FMALDGKREIVC;KENGTQIGYNGV;LYVAKENG;TGVNFVSILVVPS;TGVNFVSILVVPSLD;WQKTSAKD 6 6.1 1.0029 -0.85097 0 0 0 14.6782 9.00801 0 0 10.1872 4.95089 2.6312 0 13.7194 0 0 9.98314 A0A8C0TRR2 A0A8C0TRR2_CANLF Immunoglobulin superfamily DCC subclass member 4 Canis lupus familiaris (Dog) (Canis familiaris) SLDVHSVT;VRLKKKVKQYELT 2 1.8 0.98518 -0.43846 0 0 0 0 0 6.46351 0 0 0 0 0 0 0 0 0 A0A8C0TRR3 A0A8C0TRR3_CANLF "SPG7 matrix AAA peptidase subunit, paraplegin" SPG7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DEEERRRKEREDQ;IGGLGAARV;MDGMGTTDHVIV;VGSGRLRGPCSGWTLGLSPG 4 6.8 1.0025 -0.77446 0 0 0 0 0 6.82922 9.44681 0 0 0 0 0 0 0 9.60424 A0A8C0TRS2 A0A8C0TRS2_CANLF Dynein regulatory complex protein 9 (IQ domain-containing protein G) IQCG Canis lupus familiaris (Dog) (Canis familiaris) motile cilium [GO:0031514] DIIAREEKGKKQ;LLLEEIEKLEEKLEFWMEKFDKD;NRYMKRNTDLQISQ;VEPLSILDVLRI 4 14.8 0.99412 -0.0309 0 0 8.73589 0 0 0 0 0 8.9498 0 0 0 0 0 0 A0A8C0TRT1 A0A8C0TRT1_CANLF SAP domain-containing protein SAFB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] SRVHMRGERSKGCAQARCMSTASRR 1 3.8 0.97999 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 8.22526 0 0 A0A8C0TRT4 A0A8C0TRT4_CANLF Cilia and flagella associated protein 298 CFAP298 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cilium movement [GO:0003352] EAGVCVTIEMVEAALDQL;KEFENKEDLSGTQAGL;KELRRTKT;KNEKTKIIVKIQQLPEKV;MIVYPMGLPPYD 5 28.6 0.98769 -0.34009 0 0 12.0185 0 9.54326 9.8384 0 0 8.17183 0 0 0 0 0 0 A0A8C0TRT5 A0A8C0TRT5_CANLF Protein FAM186B Canis lupus familiaris (Dog) (Canis familiaris) ESKVERREEELSWERQR;FPSKHWECVPL;LYFQNSLQVLQT 3 5 0.98142 0.035491 0 0 0 0 0 6.62873 0 0 0 0 0 0 0 0 0 A0A8C0TRU1 A0A8C0TRU1_CANLF Heat shock protein 60 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell activation [GO:0050870]; positive regulation of type II interferon production [GO:0032729]; protein import into mitochondrial intermembrane space [GO:0045041]; protein refolding [GO:0042026]; T cell activation [GO:0042110] chaperonin-containing T-complex [GO:0005832]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087] EEAGDGTT;VTVAKSIDF 2 12.8 1.0039 -0.80421 0 0 0 0 0 0 0 0 0 7.06383 0 0 0 0 0 A0A8C0TRU7 A0A8C0TRU7_CANLF Vav guanine nucleotide exchange factor 1 VAV1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] APRCPSSYALRTSVPFC;DQIDDTVEEDEDLYDCVEN;KYTDTLGSIQQHFMKPLQ;TEPMPMPPKMTEYDKRCC 4 9.1 0.98608 -0.42852 10.5482 0 0 0 9.02184 0 0 0 0 0 10.4542 0 0 0 0 A0A8C0TRV0 A0A8C0TRV0_CANLF Transmembrane serine protease 2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] PGVYGNVTVFTDWIYRQM 1 3.8 0.95068 0.057807 0 0 0 0 0 0 9.28635 0 0 0 0 0 0 0 0 A0A8C0TRW1 A0A8C0TRW1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) KKKKKKKK;KKKKKKKKKKK;KKKKKKKKKKKRNL;KKKKKKKKKKRNLTEE;KKKKKKKKRNL;KKKKKKKKRNLT;LTKKKKKKKKKK;NLTKKKKKKKKKKKRNL;RNLTKKKKKKKKKKKRN;TKKKKKKKK;TKKKKKKKKK;TKKKKKKKKKK;TKKKKKKKKKKKRNLTE 13 3 0.97799 0.047689 0 5.70543 4.32567 0 5.71496 4.3624 6.74833 0 0 0 5.7046 7.33994 8.42966 0 0 A0A8C0TRX1 A0A8C0TRX1_CANLF Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) CTLA4 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; regulation of T cell proliferation [GO:0042129] plasma membrane [GO:0005886] TGLYICKVELMYPPPYYV 1 10.6 0.98363 -0.25658 0 0 0 0 0 0 0 0 9.26531 0 0 0 0 0 0 A0A8C0TRX4 A0A8C0TRX4_CANLF Golgi transport 1B SPX Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] FRFFFQKHKMKATGFF 1 12.5 0.96002 0.049233 0 0 6.87258 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TRX9 A0A8C0TRX9_CANLF Signal transducing adaptor molecule 2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] LVLAHHFSPPLKPEKATN;SIDPTDAKPDSQ 2 5.8 0.95906 0.049093 0 0 5.90713 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TRY4 A0A8C0TRY4_CANLF C2 domain-containing protein CC2D2B Canis lupus familiaris (Dog) (Canis familiaris) DELVIPAYGEVGS;DHLQTFAEGQDEDFME;EESGEIMSLPSPIRQSWNFR;FQEYESQI;KAAEYEDDQEKIKKQ;KRTSLLAKL;LEQLQDEFNFVSE;TPMAVHFDYLKESFWKQLL;TYRKLKAL 9 8.9 1.004 -1.1044 0 5.91028 5.53748 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TRY9 A0A8C0TRY9_CANLF Nitric oxide synthase (EC 1.14.13.39) NOS1 Canis lupus familiaris (Dog) (Canis familiaris) nitric oxide biosynthetic process [GO:0006809] calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517] AFGHAVDTLLEEL;ALMERLEDAPPVNQL;EDAPPVNQLVKVELLE;FSGWYMGTEI;LVLEVPIRHPKFEWFK;QRQFDIQHKEV;VEVLEEFPSIQ;VHLTVAIVSYRTGDGE;VLEVPIRHP;VLSLLTSGNKGING 10 8.4 1.0032 -1.52 12.6885 0 9.93683 0 6.50082 9.50313 0 0 11.2661 0 0 6.10511 0 0 14.9051 A0A8C0TS14 A0A8C0TS14_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] IDVLRYFF;KPRPVRIV;KVRRSLRLKFSL;TTVEKSSIGSY 4 3.8 1.0037 -1.9706 8.67165 0 0 0 0 0 0 0 0 0 0 9.62051 0 0 0 A0A8C0TS15 A0A8C0TS15_CANLF YAP binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) embryonic organ development [GO:0048568]; hippo signaling [GO:0035329] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELFERGPSNAFFLVKFWADLNTNI;HRCGLKVL;PAPPWQGRS;PCCCQLGGDPSPSRGV 4 12.9 1.002 -1.2318 0 8.3844 0 0 0 0 0 0 0 0 9.25259 6.80025 0 8.88612 15.6425 A0A8C0TS18 A0A8C0TS18_CANLF Cytochrome P450 family 20 subfamily A member 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ALMQLESILKKII;ASRQAAGIPGI;HERYGPVVSFWFGR;VLKQHINPN 4 10.1 0.98856 0.028076 0 0 5.31839 4.13701 0 11.7854 4.27553 0 0 0 4.11894 0 0 0 0 A0A8C0TS19 A0A8C0TS19_CANLF ATP binding cassette subfamily D member 2 ABCD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GQKQAMVSERTEAFTTA;IVKSIVEKKPRTFIIKLIKW;IVKSIVEKKPRTFIIKLIKWLMIAI;LHCTETTC;NQTYYKVINMDGRL;SIVEKKPRTFIIKLIKWLMIAIP 6 9.3 1.0022 -1.8756 0 0 7.71459 0 0 4.57446 0 0 0 0 0 0 0 9.79492 8.73223 A0A8C0TS30 A0A8C0TS30_CANLF glucuronosyltransferase (EC 2.4.1.17) LOC119874464 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] FSPGYAFEKHSGGLPLPPSYVP;VITEPSYKENATRLSRI 2 7.1 0.99207 0.0044518 0 0 0 0 0 0 0 0 11.6007 0 0 0 0 0 0 A0A8C0TS31 A0A8C0TS31_CANLF Proline rich 33 LOC102153419 Canis lupus familiaris (Dog) (Canis familiaris) GVTMLIVAGMCP;HGPAWRTSLPSPRPS;SEAPKAEHWEEPPMAGPTT 3 9.2 0.98924 -0.50761 0 0 0 0 0 0 0 0 10.1876 0 0 0 0 9.55 0 A0A8C0TS34 A0A8C0TS34_CANLF Protein transport protein SEC23 SEC23B POLR3F Canis lupus familiaris (Dog) (Canis familiaris) COPII-coated vesicle budding [GO:0090114]; intracellular protein transport [GO:0006886]; transcription by RNA polymerase III [GO:0006383] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; RNA polymerase III complex [GO:0005666] metal ion binding [GO:0046872] DPWPVTQGKRPL;ESKKLIKAVK;LTEINKILKNLESKKL;PPEPVLLD;SPFLQVFNNSPD;TATNGHCI 6 8.7 0.99104 -0.27458 0 0 0 0 0 0 0 0 0 0 0 4.26469 0 0 0 A0A8C0TS43 A0A8C0TS43_CANLF Seizure related 6 homolog like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EATTKRALPS;ESLTFMCYEGF;IQYTCNPGFVLEGSSLLTC;PYSQITVETE;RYYSSLRLPLMYSHPYS;VRGARITYQCDPGYDIVGSDTLT 6 7.9 0.98723 -0.50226 10.3602 0 0 10.2949 0 0 0 11.269 0 10.1916 0 0 12.3966 0 0 A0A8C0TS55 A0A8C0TS55_CANLF UDENN domain-containing protein DENND1C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] guanyl-nucleotide exchange factor activity [GO:0005085] CHRGDSDSCFSLPD;GVHSSLAERVRE 2 3.3 0.91437 0.11132 0 0 0 0 8.60995 0 0 0 0 0 0 7.49466 0 0 9.15856 A0A8C0TS59 A0A8C0TS59_CANLF BAG cochaperone 3 BAG3 Canis lupus familiaris (Dog) (Canis familiaris) protein-folding chaperone binding [GO:0051087] PREGHAVYPHL;TDKNKKSAGNEEDPKT 2 4.7 0.98212 -0.24839 0 0 0 0 0 0 11.1187 0 0 0 0 0 0 0 0 A0A8C0TS60 A0A8C0TS60_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] KEGSGGPGPGHTLKQDPVPRERPRE;NSRGTTWSRKHTYLN;SQIISYWGYPDEVYDIVT 3 7.4 0.9751 0.035538 0 0 0 0 9.73188 0 0 0 0 0 0 0 0 0 0 A0A8C0TS61 A0A8C0TS61_CANLF Ribonuclease (EC 3.1.26.4) Canis lupus familiaris (Dog) (Canis familiaris) RNA catabolic process [GO:0006401] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523] PIGREPEPLRGRGKRAPRT;VARDQAVKSWHF 2 6.1 0.95305 0.04941 0 0 0 0 0 0 0 0 0 6.31709 0 0 0 0 0 A0A8C0TS74 A0A8C0TS74_CANLF Cilia and flagella associated protein 58 CFAP58 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] CEQLSQENQQKASELKAKEEEVHQM;DTRQTEIKALQ;EIQNYKDEAQ;EVEASKKQAEL;MAEGKSEKLALEETA;VEQVISQFQQEIQQ 6 9.9 1.0045 -1.0538 0 10.1888 10.6894 0 0 8.61978 0 0 13.1716 0 0 0 9.0133 0 0 A0A8C0TS77 A0A8C0TS77_CANLF "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase)" ALG3 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] EALFLHRAFHVALLAAH;EKNRTRNWSASVRWDG 2 7.5 0.96481 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.39489 A0A8C0TS83 A0A8C0TS83_CANLF Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) Canis lupus familiaris (Dog) (Canis familiaris) phosphate-containing compound metabolic process [GO:0006796] cytoplasm [GO:0005737] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] RVKVLGILAMTDEGE;VLIYADKHIFH 2 15.6 0.9909 -0.53783 11.3957 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TS85 A0A8C0TS85_CANLF Cysteine/serine-rich nuclear protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EDDDDKGDSF;EDEDEEEE;EDEDEEEEEDEDDDDK;EEDEDEEEEEDEDDDDKGDS;EEEDEDEEEEEDEDDDDKGDSF;EEEEEEEEEEEEEEEEEDGSS;EEEEEEEEEEEEEEEEEEED;GEEEEEEEEEEEEEEEEEEE;LDCQGEEEEEEEEEEEEEEE;TSVPSQGG;TVESEEASTLT 11 11.5 0.98948 -0.52138 7.20633 6.71521 15.3364 0 0 5.48826 0 0 0 3.65295 0 0 5.28274 0 0 A0A8C0TS96 A0A8C0TS96_CANLF CCHC-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GGGGGGGG;IADPGRGGAGGAEGAGP;SSSVYKSASPYGSLNNI 3 12 0.93555 0.092454 0 10.0816 0 0 0 0 0 0 0 0 9.22101 0 0 0 0 A0A8C0TSA4 A0A8C0TSA4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) L-arginine import across plasma membrane [GO:0097638] plasma membrane [GO:0005886] L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] TVIVLLLVLITGITRVI;VIVLLLVLITGITRVIWRQPQ 2 6.1 0.93557 0.093393 0 0 0 0 4.86448 0 0 0 7.80439 0 0 0 0 0 0 A0A8C0TSB0 A0A8C0TSB0_CANLF Myosin VA ARPP19 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050] cytoplasm [GO:0005737]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] APEVTAPGAPAY;ATTPHYVRCIKPNDFKF;IIVPGMLEYESLQ;IVVMENNIQ;IYGEDIINAYSGQNMGDMDP;KNLQNSLAK;KTVRKLKKQLKVFAKKIGE;LVEETKQLELDLN;LVSNLKEENTLL;QKYWRMYI;QLKVFAKKIGEL;RWTYQEFFSRYRVLMKQKD;TVRKLKKQLKVFAKK;VAIRIYHRFIVVME;VRKLKKQLKVFAKKI 15 8.8 1.0032 -2.2729 0 9.74024 11.322 8.27687 0 0 9.86494 9.17996 10.8079 7.72935 0 0 0 0 0 A0A8C0TSB7 A0A8C0TSB7_CANLF Cyclin-dependent kinase 5 activator CDK5R2 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase 5 complex [GO:0016533] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575] DPLVQQRN;EPDKERFWQRCLRL;LVAASAKKKKGSKKVTP 3 10.5 0.98761 -0.40438 0 0 0 0 0 0 0 0 0 6.20528 0 0 5.90862 0 0 A0A8C0TSC6 A0A8C0TSC6_CANLF MOB kinase activator 2 MOB2 Canis lupus familiaris (Dog) (Canis familiaris) DLGLTACLPAPPLAEG;GGRGGGGG;LVKKICKYLFHVLAH;TTFFHHVNLQYS 4 15.9 0.99217 -0.14188 0 0 0 0 0 0 8.32832 9.99873 0 0 0 0 0 0 0 A0A8C0TSD7 A0A8C0TSD7_CANLF Major facilitator superfamily (MFS) profile domain-containing protein SV2B Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836] synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] ENQVHQRGK;LKQVHDTNMRAK;QGYGAFLFCRLLSGI;SRNQGMDDY;VIWFTMALSYYGLTVWFPDMIRYFQ;YFKHVLFEDTF 6 12.3 1.0032 -2.1489 0 4.36597 10.5626 9.37667 7.0177 0 0 0 0 0 0 0 4.44923 8.46262 8.45368 A0A8C0TSF0 A0A8C0TSF0_CANLF Calcium/calmodulin-dependent protein kinase type II subunit delta (EC 2.7.11.17) CAMK2D Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] KTIIISLLFCTDKTFTLV 1 2.9 0.9719 0.048313 0 0 0 0 0 0 0 0 0 6.33771 0 0 0 0 0 A0A8C0TSG7 A0A8C0TSG7_CANLF Cell cycle progression 1 CCPG1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PAFRRRRARKKTVSSSESE;SAEHDCSENYDSFRKSCSG;SSESYGNPDSPN 3 6.6 0.99051 -0.53493 0 0 0 0 0 0 0 0 0 7.7137 0 0 0 7.363 0 A0A8C0TSI1 A0A8C0TSI1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AGLVLSRAPRVKQQRAPLPL 1 12.1 0.97219 0.048206 0 0 0 0 0 0 0 0 0 0 0 5.37121 0 0 0 A0A8C0TSJ6 A0A8C0TSJ6_CANLF FAM21/CAPZIP domain-containing protein LOC119868814 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DDDDDDDDDFF;DEDEESDLFT;EDDDGCDIFADSEKEE;EEEDDDGC;FDDDDDDDDDDF;FDDDDEEDQWNITDSQR;GAVSLFLGDT;GVFQDEELLFSHK;PAKSQPLISEKKRLVK;PTAQMSDEEEDDD;VEGAVESSEL 11 8.8 0.9768 0.046227 0 0 0 0 0 0 0 0 6.196 0 0 0 0 0 0 A0A8C0TSJ7 A0A8C0TSJ7_CANLF Piwi like RNA-mediated gene silencing 3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] RNA binding [GO:0003723] KQEATEFFDHKLVIWPGYVTSILEY;LLLPKTELVSLLKNQVVK;PIMLVPEL;PQQVTYKYNI;VGGLYLPVKLTFIVVKKRI;VGGLYLPVKLTFIVVKKRINT;VGGLYLPVKLTFIVVKKRINTRFF;VRIFQGRR 8 11.4 1.0031 -1.5016 0 0 0 7.84831 0 0 0 12.8678 0 6.97246 4.28437 0 0 9.24205 0 A0A8C0TSK2 A0A8C0TSK2_CANLF FHF complex subunit HOOK interacting protein 2A FHIP2A Canis lupus familiaris (Dog) (Canis familiaris) EISIMTLRMFEHL;FTPKLLLVRKRLLG;FTPKLLLVRKRLLGLE;INVHRPVQNK;IPEFTPKLLLVRKRLLGL;ITLLEGVIVLEEFCKE;LEERNYTEYKPVCP;LLLVRKRLLGLE;LSNQEWLSSSP;PGPRPPRLSRPRRVRPPRR;RFFIGVMEPQLMQT;TVEAINWGLD 12 13.1 1.0022 -1.3677 0 7.14435 9.13291 5.75902 8.62596 0 0 7.49442 10.7722 0 0 4.8055 0 0 0 A0A8C0TSP2 A0A8C0TSP2_CANLF Ligand dependent nuclear receptor corepressor LCOR Canis lupus familiaris (Dog) (Canis familiaris) DADGFPIKPKSTDGMK;DDDDVDTVVDDQPKFVEW;DIFPSSDPISTV;ENQELIANFNA;GAPGGAGR;GGGGGGGG;LESSEQDSRPKQENHLHS;LVIVKKLNTRLPGDI;PPKNCERESISDWTFDENCLFCCL;PSPMPAVHKASNGHSRTKM;TANTQDKDDNSDA;TESQPDTEDLQ 12 9.6 0.97445 0.041303 0 0 0 0 0 6.65578 0 0 0 0 0 0 0 0 0 A0A8C0TSQ2 A0A8C0TSQ2_CANLF Popeye domain containing 2 POPDC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GFLGTGYVCCLMWGWFDAC 1 5.5 0.95274 0.04948 0 8.67228 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TSQ3 A0A8C0TSQ3_CANLF Heat shock protein family A (Hsp70) member 12A HSPA12A Canis lupus familiaris (Dog) (Canis familiaris) HQIRLPEG;YSGFVPYL 2 2.2 1.0033 -1.6135 0 0 9.57669 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TSR6 A0A8C0TSR6_CANLF Polycystin-2 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] ciliary membrane [GO:0060170]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; monoatomic ion channel complex [GO:0034702] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; potassium channel activity [GO:0005267] EGAGANGS;GGGGGGGE;GGGGGGGG;RGLGVALSPALV;SLDDSEEDDDEDSGH;SREKYLKSVLRE;TQPGNRTEADNRSFIYYE;VPRIRQLK;VSQSGFVSP 9 7.9 1.0029 -2.1701 11.2648 0 11.324 0 0 0 10.9879 11.1496 0 11.2087 8.7128 10.3498 11.364 7.71431 16.4144 A0A8C0TSS3 A0A8C0TSS3_CANLF Protein arginine methyltransferase 8 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] protein-arginine N-methyltransferase activity [GO:0016274] IEDRQYKDFKIHWWE 1 3.9 0.94974 0.053907 0 8.92038 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TST6 A0A8C0TST6_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" RNA binding [GO:0003723] DESDEREDEDYADEK;EDVDEKMFEDSDDKEDEEG;EKVFDDESDEREDEDYAD;REFDEESDDKEEGEDTYEK;SDDKEEGEDTYEKVFDDES;SGLPPDITVDEFIQ;VLSSDDENDKIRG 7 11.2 1.001 -0.94564 0 0 10.2276 0 0 0 10.5779 12.4642 0 0 12.749 11.1634 0 0 0 A0A8C0TSU9 A0A8C0TSU9_CANLF Protein ABHD13 (Alpha/beta hydrolase domain-containing protein 13) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyl-(protein) hydrolase activity [GO:0008474] GEASEEGLYLDSEAVLDY;VLGSLPYFSFTFNS 2 10.6 0.98475 -0.24696 0 0 0 0 0 0 0 0 0 0 10.5683 0 0 0 0 A0A8C0TSV4 A0A8C0TSV4_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)" PLCB2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] EEVEEEEEEESGNLDEE;GVVKLQRRHEKELRDLERRGARRRE;PDTWADLTVAL;TLSKLPGDGCFQDP;YYLYWTYQSKETEFLDITSIR 5 7.3 0.99392 -0.026769 0 8.71376 0 7.27342 0 9.24634 0 0 0 7.87271 0 0 0 0 6.95373 A0A8C0TSV5 A0A8C0TSV5_CANLF Transporter SLC6A18 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] symporter activity [GO:0015293] PLSYRAWNTQYLPSI;QPERVARLHLEACHLEDFLDKSASG 2 7 0.92761 0.10624 0 0 0 0 0 0 0 8.99317 0 0 0 0 6.60977 0 0 A0A8C0TSY0 A0A8C0TSY0_CANLF Mediator of RNA polymerase II transcription subunit 13 MED13L Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] DEDSTSGNF;DLDNIFDNSDDDELG;EVIVGGVRLVYP;EVSSSRKYDK;FELAELLGQQCIQVMPRQTTF;LIEEWQYFYPMVLK;QVLVSPYGLNGT;SASVVGQN;SSNSRQTLPCV;VEDGLGSPKPE;VGSLADPDYLN;VSSAGSAFNPT;WSSEENDNHSR 13 7.4 0.94003 0.10023 0 0 0 0 0 0 0 0 0 0 0 0 0 7.61508 8.42307 A0A8C0TSY4 A0A8C0TSY4_CANLF Protein kinase domain-containing protein DAPK2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GGTSSLTGCMLQASM;TIQDDVETLI 2 4.5 0.98765 -0.37306 0 0 0 0 12.5999 12.6932 0 0 0 0 0 13.3693 0 0 13.5798 A0A8C0TT13 A0A8C0TT13_CANLF Vacuolar protein sorting-associated protein 33A VPS33A Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] RLELMDIIAENVLSE;VLDYYKREILQT 2 4.7 0.98457 -0.2547 0 0 0 0 0 0 9.12756 0 0 0 0 0 0 0 0 A0A8C0TT26 A0A8C0TT26_CANLF Bms1-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] GTP binding [GO:0005525] AFASEDETEESSSLNTEEED;ARKKHLDKKRKLKE;DDETEDEADTEMMDMM;DEEDESGDSNDEDDEE;DEEDESGDSNDEDDEEM;DEELYGDFEDL;DPCALPEQQK;EDEADTEMMDMM;EDESGDSNDEDD;EEDESGDSNDEDDEEMSEGD;EERDISESKVVGD;ESGDSNDEDDEEMSE;GQLRLAHGVK;IFGDEEDESGDSNDEDDEEM;IKIVKKLKLTGFPYK;KSIKIVKKLKL;LDDSCSDDETED;MYVRIEIENV;VQSVSDIMP;YPVSIPAF 20 14 1.0026 -2.5784 0 4.98664 8.59062 5.21793 4.78173 5.71831 11.78 8.48257 5.71345 5.14775 0 7.78084 8.80465 9.07342 6.82043 A0A8C0TT32 A0A8C0TT32_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2B1 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] EIAFFSRWWQQQT;ERGKPCFVPTQPGLSP;PSPSRTCRRPRWQ;PYGSGDSAPLNEA;RFDPDTGFLVELENLE;VGEGSGNL;VISRFDTVLETKGLFYT;VNSRIYIRV 8 10.3 1.0031 -2.3472 0 0 0 9.87685 10.3182 11.304 11.0456 0 12.0101 0 0 0 10.8496 10.0445 10.9581 A0A8C0TT33 A0A8C0TT33_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLQNLIDSLQKANQCCGAYGP;LPPTGHPRTPGDVGSP;PPPPRPGRARSWRA 3 8.8 0.99646 -0.11284 0 0 0 0 0 0 10.8032 0 0 0 0 0 0 10.3022 6.38293 A0A8C0TT37 A0A8C0TT37_CANLF Zinc finger and BTB domain containing 20 ZBTB20 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PGGNDSWTMLGVWS;QEMEDDYDY;VGNIHIKQE 3 4.3 1.0032 -1.9203 0 0 0 0 0 0 0 0 0 9.51037 0 0 0 0 0 A0A8C0TT46 A0A8C0TT46_CANLF PX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] phosphatidylinositol binding [GO:0035091] AGAVGPPRRPAAMEQ;GKGAGPRGA;MKLNRFQA 3 5.3 0.98652 -0.45647 0 0 9.45646 0 0 0 0 0 0 0 0 0 0 0 8.20403 A0A8C0TT79 A0A8C0TT79_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SIVASGNNLSN;VGSLPSIY 2 5.7 1.0032 -1.3346 9.39133 0 0 10.0701 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TT80 A0A8C0TT80_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) UGT1A6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] UDP-glycosyltransferase activity [GO:0008194] GVPMVMLPLFGDQMDNAKR;LFCHYFFKTPLEVASE;YSTAYNLEELNQ 3 8.9 0.99134 -0.20625 0 8.03023 0 0 0 0 0 0 0 0 0 9.3192 0 0 0 A0A8C0TT81 A0A8C0TT81_CANLF Testis expressed 9 TEX9 Canis lupus familiaris (Dog) (Canis familiaris) AEKYKLELSKSR;MKSWGRLNAE;MKSWGRLNAELQ 3 6.7 1.0023 -1.1689 0 0 0 0 8.51995 7.61985 0 0 0 0 0 0 0 0 0 A0A8C0TT94 A0A8C0TT94_CANLF PCNA-associated factor (PCNA-associated factor of 15 kDa) (PCNA-clamp-associated factor) PCLAF Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726]; translesion synthesis [GO:0019985] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] chromatin binding [GO:0003682] LCHLITQM;RKEHVLCHLIT;SVPGTYRK 3 32.8 1.0025 -2.1733 9.49975 9.81852 0 0 0 0 9.71158 10.7711 9.48985 0 0 0 0 9.58305 0 A0A8C0TTA5 A0A8C0TTA5_CANLF L-gulonate 3-dehydrogenase (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] "NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LDQIDDKVVLSSSTS 1 5.1 0.84934 0.15116 0 0 0 0 0 0 0 9.69551 0 0 0 0 0 0 0 A0A8C0TTB3 A0A8C0TTB3_CANLF Protein kinase domain-containing protein CAMK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] EQALQHPWIAGDTALDKNIHQS 1 5.9 0.98724 -0.23387 0 0 0 9.53986 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TTC0 A0A8C0TTC0_CANLF TLC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" membrane [GO:0016020] AAGGGGGG;EPPGAEPRVHPAE;GGGGGGGA;GGGGGGGG;GVSQEERQEPPGAEPRV;VTVGFHLA 6 10.7 1.0021 -0.98717 0 0 0 0 0 0 0 9.33107 0 6.01109 0 0 0 0 0 A0A8C0TTE5 A0A8C0TTE5_CANLF Nucleoside-diphosphate kinase Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] ATP binding [GO:0005524]; nucleobase-containing compound kinase activity [GO:0019205] CEPVLTFYQQ;FDCSMDTM;ILKSPLIIFVMGGP;LKSPLIIFV 4 16.6 1.0032 -1.927 0 0 0 0 0 0 8.56575 11.5734 0 0 0 8.87098 0 0 0 A0A8C0TTH1 A0A8C0TTH1_CANLF SSD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KENGTQIGYNGV;LYVAKENG;TGVNFVSILVVPS;TGVNFVSILVVPSLD;VGNFCYCFCDCGSNRFH;WQKTSAKD 6 12.1 0.97659 0.046227 0 0 0 0 6.02314 0 0 0 0 0 0 0 0 0 0 A0A8C0TTH3 A0A8C0TTH3_CANLF Gap junction protein Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] CRWEPGRHPKPSQSTDRTL;KKKKKKGG 2 6 0.95179 0.049872 0 0 0 0 0 0 0 0 12.1635 0 0 0 0 0 0 A0A8C0TTK2 A0A8C0TTK2_CANLF DNA nucleotidylexotransferase (EC 2.7.7.31) DNTT Canis lupus familiaris (Dog) (Canis familiaris) DNA modification [GO:0006304]; DNA repair [GO:0006281] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] KDTEGIPCLGDQ;MRRDYTASPNPELQKT 2 5.7 0.93349 0.099673 0 8.50494 0 0 0 0 9.02042 9.25868 9.10486 0 0 0 8.46365 0 0 A0A8C0TTL1 A0A8C0TTL1_CANLF protein S-acyltransferase (EC 2.3.1.225) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] FPCRWLAQNGEWA;LAPHPWGGALH;MAEAVWLQ;NHRAFRLQWCQKCCFHCPP;RAGGGGGS;VPAAGFLV;YHCPWCNICVED 7 8.3 1.0026 -1.7811 12.0905 8.66885 9.49149 7.30979 6.64235 11.1144 11.8738 0 10.3963 0 0 0 12.4174 0 12.1272 A0A8C0TTM0 A0A8C0TTM0_CANLF Phosphatidate cytidylyltransferase (EC 2.7.7.41) Canis lupus familiaris (Dog) (Canis familiaris) CDP-diacylglycerol biosynthetic process [GO:0016024] membrane [GO:0016020] phosphatidate cytidylyltransferase activity [GO:0004605] AAYMLSKYQYFVCPVE;FRTLSWYFLLCVNY 2 6.5 0.98241 -0.25039 0 0 0 0 0 0 0 0 0 0 0 8.52015 0 0 0 A0A8C0TTN1 A0A8C0TTN1_CANLF TP53 target 5 Canis lupus familiaris (Dog) (Canis familiaris) IQGYFSYVSILSPSVRQIQDEEPK;TGSNVCDRVEQDNEEFQE;TPMGDKKQQETVAD 3 21.8 0.85 0.1507 0 11.127 5.37379 0 0 0 0 0 8.64494 0 0 0 0 0 0 A0A8C0TTN5 A0A8C0TTN5_CANLF Hemimethylated DNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] AEGASLDIFDYIYIDAF;EEFMCCGDHKNLEYN;GAEGASLDIFDYIYIDAFGKGKQLT 3 5.5 0.99413 -0.13242 0 5.01903 0 0 10.1838 10.0694 0 0 0 6.32072 0 0 0 0 0 A0A8C0TTN8 A0A8C0TTN8_CANLF Ankyrin repeat domain 1 Canis lupus familiaris (Dog) (Canis familiaris) FVEQEKTHRRTEPQADMMVMKVEEL;VIIQLKKRKKYRKTKVPVVKEP 2 13.9 0.94498 0.082237 0 0 0 0 6.0928 0 0 8.40327 4.35664 0 0 0 0 0 0 A0A8C0TTP8 A0A8C0TTP8_CANLF Myosin VA ARPP19 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] APEVTAPGAPAY;ATTPHYVRCIKPNDFKF;FDLAEYRQVLSDLAIQ;IYGEDIINAYSGQNMGDMDP;KTVRKLKKQLKVFAKKIGE;LVEETKQLELDLN;LVSNLKEENTLL;QKYWRMYI;QLKVFAKKIGEL;RWTYQEFFSRYRVLMKQKD;TVRKLKKQLKVFAKK;VHFQDLEYRLDPK;VRKLKKQLKVFAKKI 13 8.3 0.98935 -0.19956 0 11.0016 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TTS2 A0A8C0TTS2_CANLF Calcium homeostasis modulator 3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] LSHRAATVPGTRLPQ 1 4.4 0.95139 0.053901 0 0 4.38474 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TTT6 A0A8C0TTT6_CANLF SH2 domain-containing protein BLNK Canis lupus familiaris (Dog) (Canis familiaris) DDFDSDYEHPDEHSD;PYTLVVFFNKR;VDEEEQWSDDFDSDYEHPDEHSDSE;VDNRSSQRQ;VEDGDENYIHP 5 13.2 0.99587 -0.095541 8.71091 0 9.3017 0 0 0 0 10.6719 0 0 0 0 10.8074 0 0 A0A8C0TTT7 A0A8C0TTT7_CANLF E3 ubiquitin-protein ligase RNF168 (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) RNF168 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212] nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] KEQMKPNR 1 1.4 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.51227 A0A8C0TTU7 A0A8C0TTU7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK39 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ASGCDGSE;LEKCQTSMDELLKEIQ;PGSSGHLHKTEDGDWEWSDDEM;PYFPKKKKK;PYFPKKKKKKKIKDF 5 10.3 0.95073 0.053874 4.36569 0 0 0 0 0 0 0 0 0 0 0 0 5.99406 0 A0A8C0TTV9 A0A8C0TTV9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) AKKINKKKKKKKKKKKKK;EAKKINKKKKKKKKK;EAKKINKKKKKKKKKKKKKK;EQEAKKINKKKKKKKKKK;EQEAKKINKKKKKKKKKKKK;INKKKKKKKKKKKK;INKKKKKKKKKKKKKK;KINKKKKKKKKKKKKK;KINKKKKKKKKKKKKKKK;KKINKKKKKKKKKKK;KKKKKKIKINKTIEERHLNK;KKKKKKKK;KKKKKKKKIKINKTIEE;KKKKKKKKKIKINKTIEE;KKKKKKKKKKI;KKKKKKKKKKIKINKTIEE;KKKKKKKKKKIKINKTIEERH;KKKKKKKKKKK;KKKKKKKKKKKI;KKKKKKKKKKKIKINKTI;KKKKKKKKKKKIKINKTIEE;KKKKKKKKKKKK;KKKKKKKKKKKKIKIN;KKKKKKKKKKKKIKINKTIE;KKKKKKKKKKKKIKINKTIEE;KKKKKKKKKKKKK;KKKKKKKKKKKKKI;KKKKKKKKKKKKKK;KKKKKKKKKKKKKKI;KKKKKKKKKKKKKKK;KKKKKKKKKKKKKKKKI;KKKKKKKKKKKKKKKKKKI;NKKKKKKKKKKKK;NKKKKKKKKKKKKK;NKKKKKKKKKKKKKK;NKKKKKKKKKKKKKKK;QEAKKINKKKKKKKKKK;QEAKKINKKKKKKKKKKKK;QEAKKINKKKKKKKKKKKKK;QEAKKINKKKKKKKKKKKKKK;SLYEASITLIPKPD 41 5.9 0 1.3737 0 10.9685 8.80964 0 7.04843 5.94066 10.358 7.9028 6.31893 9.68177 3.11894 7.97396 9.98755 9.50295 9.79281 A0A8C0TTW6 A0A8C0TTW6_CANLF Recombination signal binding protein for immunoglobulin kappa J region like RBPJL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FPGDSPGG;PEYSARPGPPGALEP;TDPSAPPGPLTHLSLPDSS 3 8.1 0.9863 -0.38858 0 0 0 0 0 0 12.5049 0 9.29992 0 0 0 0 0 0 A0A8C0TTX9 A0A8C0TTX9_CANLF Dynein axonemal heavy chain 3 DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DEFNRIEVEVL;DITGTSFSN;DTYYIPPHGSYQS;EEKLVRVQEILD;ETARMMVKIEEE;FQEWIDNGPPVVFWISGFY;ITKNYSSYDWRE;LEDVEVISMC;NESDLRISMQQV;SEDNICDLNDFQW;VRHGYMIVGDP;VTPTSYLELILTFKTL 12 4.9 0.98695 -0.38373 0 0 0 10.9217 11.0205 10.8928 0 0 11.2391 11.2736 11.2585 11.1549 0 0 0 A0A8C0TU27 A0A8C0TU27_CANLF ELKS/RAB6-interacting/CAST family member 1 ERC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] centrosome [GO:0005813]; ciliary basal body [GO:0036064]; IkappaB kinase complex [GO:0008385]; membrane [GO:0016020]; presynapse [GO:0098793] ATSGPMYLSDHENVG;QKMTQEQLQ;QRDLNQLFQQ;RRREDNLNDS 4 3.9 1.0021 -1.136 0 0 8.56079 0 8.46923 0 0 0 0 0 0 0 0 10.5498 8.5883 A0A8C0TU36 A0A8C0TU36_CANLF "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta)" ACAP2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] YDLFSELGPYMKDLGAQLDRLVVDA 1 3.3 0.98971 -0.22004 15.7702 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TU44 A0A8C0TU44_CANLF "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit)" NDUFV3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ATP synthesis coupled electron transport [GO:0042775] mitochondrial respiratory chain complex I [GO:0005747] PPKKPAQA 1 7.5 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 6.47554 0 0 0 0 0 A0A8C0TU60 A0A8C0TU60_CANLF H15 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492]; structural constituent of chromatin [GO:0030527] TIFPLRRVQGTGASGDWQ 1 6.2 0.97191 0.048313 0 0 0 0 0 0 0 0 9.50074 0 0 0 0 0 0 A0A8C0TU63 A0A8C0TU63_CANLF BTB domain-containing protein KCNG3 COX7A2L Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] LASVSVVF;LEGAHLEYC;LPITFIYHSFVQ;SIPAACWWVI 4 9.2 1.0034 -1.6229 0 11.4357 0 8.94122 0 0 7.82114 0 0 0 0 0 0 0 0 A0A8C0TU76 A0A8C0TU76_CANLF Polyadenylate-binding protein (PABP) PABPC1L Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] CDDHGSRGFGFV;LLLMLESP 2 3.3 0.95334 0.05044 0 0 0 0 0 0 0 0 0 9.23278 0 0 0 0 0 A0A8C0TU81 A0A8C0TU81_CANLF T-box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GRPDKASPDSR;VGAAETGIPFSSL 2 3.3 0.9878 -0.49631 0 0 0 0 10.5424 0 0 0 0 0 0 0 0 0 0 A0A8C0TU93 A0A8C0TU93_CANLF Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (Cell-binding sialoprotein) IBSP Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; ossification [GO:0001503] extracellular region [GO:0005576] ATKEEESDEEEEEDEEN;DEYSYYKGHSYDSYDGQ;EEEYEQTGTNEYDNGYEVYESEN;ETSNEEENNEENANSDENEDESD;KGHSYDSYDGQDYYY 5 28.6 0.98423 0.046227 0 0 0 0 6.3713 0 0 0 0 0 0 0 0 0 0 A0A8C0TUA7 A0A8C0TUA7_CANLF non-specific protein-tyrosine kinase (EC 2.7.10.2) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; regulation of keratinocyte differentiation [GO:0045616] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] GEKDLHLFEKL;LEAQPTDMRAL;LLEAQPTDMRALQDFEE;LPLSSPSPPSLPSL;TLWEMFTYGQ 5 5.4 0.98933 -0.20284 0 8.99591 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TUB0 A0A8C0TUB0_CANLF Ceramide synthase 6 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] GGFHTQRKFLND;GVRFLKKTPWLWNTRHCWYNYP;LTTDLHYYYIL;VLNTTLFESWEIVG 4 15.6 0.95386 0.05044 0 0 9.2204 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TUC1 A0A8C0TUC1_CANLF Collagen type XX alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] ASFQLQMLQIVCNDSWADEDVCCE;CPDPEPLG;EVMLTTKTPKATVGGLSP;EVVVDGPTLSAE;GARGTAGE;GPTVSPLPTLSRESK;IVCNDSWADEDVCC;IVCNDSWADEDVCCE;PLSPHTGPSGRGW;VGKAGVGEGLRGLVTTAPLPP 10 9.2 1.0031 -1.9517 0 9.23091 10.6902 7.71342 7.80497 0 0 0 5.91905 8.39759 9.08361 4.90029 8.49781 8.04237 0 A0A8C0TUC7 A0A8C0TUC7_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEEAEFYDP;FLEISLEKFLFILSRKNL;GQTTITECYDPEQN;LPMLNARYYHCAVTL;VQSYNSDINEW 5 12 1.0018 -0.96231 0 0 0 0 0 0 8.52199 0 0 9.43769 8.89458 0 0 0 0 A0A8C0TUG3 A0A8C0TUG3_CANLF Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) MAP2K1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] centrosome [GO:0005813]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; spindle pole body [GO:0005816] ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708] GADGGKPG;RKRRRRRRRRRRRRRRRRRDR;SPRRRRRRRRKRKRRRRRRRRRRRR 3 5.9 0.99073 -0.51523 0 0 9.15959 7.83352 8.18299 8.44133 0 0 0 8.2695 8.67708 9.70172 9.45988 9.30893 9.73069 A0A8C0TUH1 A0A8C0TUH1_CANLF [histone H3]-lysine(4) N-methyltransferase (EC 2.1.1.364) Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] histone methyltransferase complex [GO:0035097] histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872] AKGDDELGTLENLETNDPHLDDL;EEDDDDDTM;EELRLPLW;GLEDLVFTDASPQA;GPPRLPAPQGAL;GVMPTVGQL;LEKHTMVI;LFFCTSCGHHYHGACLD;LLCDAGTAIGGGKAEGD;MFRINNEHVIDATLTGGP;NLSNPPTP;PYPGSLPLQQQQQQQQLWQQQQQ;QQQQLQQQQQFQQQQQQL;QQQQQQQQHSAV;RREKIYEEQNRGIYMFR;TEDDVEQAADEGFDCV;TPLSPPPEASPLSP;VAVQQQQQQSL;VEAQKPEQSSL;VELPAEPSAEPP;VPASPQSQSSSQSPLTPRP;YDYQFDFEDDQHKIPCH;YHFPCATASG 23 5.7 1.0004 -2.8138 12.9826 8.17048 9.30385 11.2067 8.98868 9.61508 10.1016 0 11.4799 0 10.0756 10.4319 10.5229 11.0763 7.78588 A0A8C0TUI4 A0A8C0TUI4_CANLF THAP-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] AQNTGIVEVEEGEVNGQELCITSHS;LEGTPGDGPAPAAGGQG;LPSLMEPPTMNPVVEPLS;LVDKSGISKDDFTPPGSGA;PREPVDRKRPKRDVEPSCSGTGPGP 5 16.6 0.99159 -0.27253 6.73593 0 0 0 8.85431 0 6.79168 0 0 8.85997 0 0 0 9.05493 0 A0A8C0TUJ3 A0A8C0TUJ3_CANLF Uromodulin like 1 Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509]; peptidase inhibitor activity [GO:0030414] DECESQEHDCEP;DYVTLNVTSSSFR;GIIHHLKILSPIHCAFQN;PTEGPADHIEWHAGLPTWRTPP;SNVTSTSFHVAWAA;VGEDTVIQDYDECE;VGRSQASGFTEKGLS;VTDCCAGY 8 8.5 1.0037 -1.652 0 8.44008 0 9.52773 0 5.49153 9.60496 10.4615 0 0 9.85681 0 0 0 0 A0A8C0TUJ8 A0A8C0TUJ8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCCKPCCCES;CCCKPCCCSCCCKPCCC;CCCKPCCCSCCCKPCCCESS;CCCQSSCCKPCCSQSCCCVPVCQ;CCCSCCCKPCCCE;CCCSCCCKPCCCES;CCCSCCCKPCCCESS;CCCSCCCKPCCCESSC;CCKPCCCQSSCCKPCCSQSCCCV;CCKPCCCSCCCKPCCCESSCCKP;CCSCCCKPCCCESSCC;CCSCCCKPCCCESSCCKPCC;CCSQSSCCC;CGCSGGCGSSCCVP;CKPCCCSCCCKPCCCE;CKPCCSQSCCCKPCCCSCCCKPCCC;CSCCCKPCCCESSCCKPCCS;CSCCCKPCCCESSCCKPCCSQ;CSQSSCCCKPCCSQSCCCKPCCC;CVPACPCSSCGSCGG;GGCGSCGGS;GGCGSCGGSKGGCGSCGCSQ;GGCGSSCC;KPCCCSCCCKPCCCESSCCKP;PCCCESSCCKPCC;PCCCESSCCKPCCSQSCCC;PCCCQSSCCKPCCSQSCCCVPVCQC;PCCCSCCCKPCCCESSC;PCCCSCCCKPCCCESSCCKPC;PCCCSCCCKPCCCESSCCKPCCS;PCCSQSCCCKPCCCSCC;PCCSQSSCCCKPCCS;PVCCCVPACPCSSCG;QSCCCKPCCC;QSCCCKPCCCSCCC;QSCCCKPCCCSCCCKPCCCE;SCCCKPCCCSC;SCCCKPCCCSCC;SCCCKPCCCSCCC;SCCCKPCCCSCCCK;SCCCKPCCSQSCCCK;SCCCKPCCSQSCCCKPCCC;SSCCCKPCCSQSCCCKPCCC;SSCCKPCCSQSCCCKPCCSQSSCC;TCCGCSGG;TCCGCSGGCGSSCC 46 85.1 0.99696 -5.3922 6.82031 7.17941 6.08638 7.25333 8.26622 7.59515 9.28031 10.9871 5.56615 7.57924 8.95748 9.14124 6.35007 7.95954 4.97026 A0A8C0TUJ9 A0A8C0TUJ9_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EPVAERRTYSHRIP;IPSTICFGQGASRGFKSSKKKKNQ;PAARGAMQLPP 3 13.2 0.87706 0.13768 0 0 0 5.29913 8.84878 9.46279 0 0 0 0 0 0 10.7359 0 0 A0A8C0TUL4 A0A8C0TUL4_CANLF Galactose-3-O-sulfotransferase 2 Canis lupus familiaris (Dog) (Canis familiaris) glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101] membrane [GO:0016020] galactosylceramide sulfotransferase activity [GO:0001733] HPRSQPSLVGGE 1 2.1 0.98388 -0.24297 0 0 0 0 0 9.26339 0 0 0 0 0 0 0 0 0 A0A8C0TUL7 A0A8C0TUL7_CANLF Myotubularin related protein 14 MTMR14 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438] EDITEEDC;KQDYVDAPLSI 2 3.5 0.99419 -0.17301 0 0 0 0 0 0 0 0 0 11.5099 0 11.3569 0 0 0 A0A8C0TUN0 A0A8C0TUN0_CANLF FRY microtubule binding protein Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902] DLDLLEHQTSLVSS;DPLYIEGAWSEPT;EPIHLRRPKKRPSI;EQQFRVFRDFDFLDV;GRTNSLVFRYTKLILF;HSYTRDCATWVNV;ISDSTNGALERDTLALGALFL;KNLEPIHLR;LLCSFQVATRKLSVLILKEIRAL;LNIFVKIIQ;LVGSNQSLTEICTKLME;LVLIEVLKQIPL;MLTNVQMLNKEPEDM;NKKRRERRDLLRLQLLRIFELLADA;SSKASAAA;YSQKRTKEKLVH 16 7.6 1.0025 -0.77374 0 0 9.17433 0 0 9.2754 6.32045 11.0679 0 0 10.2115 9.06447 16.2594 0 9.64411 A0A8C0TUN3 A0A8C0TUN3_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone binding [GO:0042393] DEEDEDEEEYDEDA;DEEDEDEEEYDEDAQ;DEEGYNDGEVDDEEDEEDVGEE;EDEEDEEEEEEGEEEDVSGEE;EDEEEYDEDAQVV;GLDDDEEDEDEEEYDED;GQKRKREPEDEGEDDD;VEDEEDEEEEEEGEEEDVSGE 8 32.3 0.96276 0.049233 0 0 0 0 0 0 0 0 8.48937 0 0 0 0 0 0 A0A8C0TUN5 A0A8C0TUN5_CANLF Ephrin type-B receptor 3 (EC 2.7.10.1) EPHB3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] AIKTLKVGYTER;EFMENCAL;GVILDYEMKYF;RQRRDFLSEASIMGQ 4 5 0.98804 -0.47688 0 0 0 0 0 0 0 9.14338 8.48374 8.61224 0 0 0 0 0 A0A8C0TUN6 A0A8C0TUN6_CANLF Nop domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) box C/D methylation guide snoRNP complex [GO:0031428]; membrane [GO:0016020]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] DEIIEKKAKKAKIKL;DKVDTMIVQA;EGKINKQLKKVLKKIVK;GVENRAKLEARLR;IEKKAKKAKIKLKV;INKQLKKVLKKIVK;KKVLKKIVKEAHEPL;LKKVLKKIV;LPTCSKKRKI;QLKKVLKKIVK;SVGYAIFKVLNEKKLQEVDSLW 11 19.5 0.91605 0.11464 0 4.45431 0 0 0 4.3726 0 0 0 0 0 0 0 0 0 A0A8C0TUP7 A0A8C0TUP7_CANLF Homeobox domain-containing protein PKNOX1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ELAMSEGG 1 1.7 0.98935 -0.2632 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3346 A0A8C0TUQ5 A0A8C0TUQ5_CANLF Transient receptor potential cation channel subfamily M member 8 TRPM8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ESWIKGLK;FPEWITIPLVCIYMLSTN;IAAWGMVS;RDTLLRNCDAEG;SDEDLAEQLL;WYYVAFFTSPFVVFAWNVVFYIAF 6 7.2 1.0026 -1.765 0 0 0 0 0 0 0 0 10.9712 0 16.1541 7.23247 0 9.44383 7.17652 A0A8C0TUR0 A0A8C0TUR0_CANLF Multiple EGF like domains 11 MEGF11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APRVSYTPAMRMTSTDYSL;CCPGYYENGDFCIPLCTE;CNESCPAGYYGN;CSCENGGSCSPEDGSCEC;CSQDCPCHHGGQCDHVTGQCHC;EGLHGSGC;FGYGCQQLCECMNN;GPACFHTCSCH;GVWSVGGV;HVSGKCTCRTGF;IVLLLFLIVVLLGLFAWRRRRQ;LLLFLIVVLLGLFAWRRRRQK;NGGSCSPEDGSCECA;PVTGHCCC;RGSPYTDMPSLST;SPATGACECEPGYKGP;TGVYCEELCPPGSH;VLLLFLIVVL;VPCAAGTYGPNCSS;WGPACFHTCSCHNGGSCS 20 18.4 0.99667 -4.3118 9.04188 0 10.7759 0 10.3537 10.0083 9.90044 0 9.53432 10.4614 10.5749 8.97143 10.4876 11.43 7.66519 A0A8C0TUR4 A0A8C0TUR4_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; intracellular non-membrane-bounded organelle [GO:0043232] calcium ion binding [GO:0005509] AADLQRFKRDVTE;DDLLFEKLLTPEG;DLLFEKLLTPE;EAYDLFQFFQDLDDEESW;EIDSYDDRFQ;ETERLVADDHYAK;IKARQESLV;KEASLKTNGNST;LEHWLREAEQQAAAE;LEKAWEQRKRMLDQ;PELRELKETRFVEGHFAYEETTTHL;QEKEPIVD;QERGALLLRVLK;QIKALNVP;RCARGRVI;VIDVQVEKCRMSELVSLG 16 8.1 0.99732 -3.7849 7.33923 7.9747 7.38085 10.5712 9.20171 11.5332 9.81349 4.26258 0 0 9.22949 10.7859 0 0 7.28568 A0A8C0TUR8 A0A8C0TUR8_CANLF Unc-13 homolog C UNC13C Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887] presynapse [GO:0098793] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543] DTQLDVYNKDL;EDKTAYTPVL;ISAEIMWTLFAQ;IVDEFAMRY;IVSGSDLDASKFS;LGLYTQTTDALIK;LWQRKQEGTPTLYDSLQDQHLNEVV;SSSDRELWQRKQE;STVDLLTSITFF;VGQYDSYQEANSN;VIAINDLHWQTT;VPAVMSTLLA 12 6.6 1.003 -2.1614 0 0 0 0 10.3309 0 9.78764 0 12.8297 0 0 7.51389 0 10.8147 0 A0A8C0TUT4 A0A8C0TUT4_CANLF DNA helicase (EC 3.6.4.12) CHD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] DKLLTRLRERGNRVLIFSQMVRM;DLMSRNTI;EERQKELEEIYMLP;EQRKKVEE;FTEFDARK;KKQTVPKPRVKKQPKTQRGKRKRQD;KSSSKSKRSQGPV;MSALQKQYYKW;NSSSESSESQSESE;PGSGHGSESNSSSESSESQSESE;SYKEDDDFETDSDDL;TEKDESEVQYLIKWKG;TEKDESEVQYLIKWKGWSYIHST;TESKRQAQ;YKEDDDFETDSDDL 15 10.3 0.97887 0.035538 0 0 0 0 6.3109 0 0 0 0 0 0 0 0 0 0 A0A8C0TUV6 A0A8C0TUV6_CANLF "D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)" Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824]; FAD binding [GO:0071949] GPWGAVGN;GVAELREGGGPVELGP;GVGSRAWTLAQAAAD;VGGSVPVFDEI 4 6.5 1.0037 -1.603 6.55646 14.9742 0 0 0 9.18693 0 0 0 0 0 0 0 0 0 A0A8C0TUW4 A0A8C0TUW4_CANLF Neurexophilin and PC-esterase domain family member 3 Canis lupus familiaris (Dog) (Canis familiaris) NPQELGPEVSLFNSDWYNFQLDTIL 1 4.9 0.97868 0.035538 0 8.031 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TUW5 A0A8C0TUW5_CANLF 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) Canis lupus familiaris (Dog) (Canis familiaris) 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; one-carbon metabolic process [GO:0006730] cytosol [GO:0005829] "formyltetrahydrofolate dehydrogenase activity [GO:0016155]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AGTVFVNTYNKTD;CQHGVEEG;EDHMFIAKEES;KECEILPDDTVSTLYNRF;VTWGQHHEAAEG 5 6.7 0.94655 0.05044 0 0 0 2.95051 0 0 9.8004 0 0 0 0 0 0 0 0 A0A8C0TUX1 A0A8C0TUX1_CANLF Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA--protein transferase activity [GO:0004057] GGGGGGGA;GGGGGGGG;PTVSQVRLVPVSFE;TFQESYQVYKRYQM;WGGGGGGG 5 5.9 0.98686 -0.23359 0 0 0 0 0 0 0 10.4056 0 0 0 0 0 0 0 A0A8C0TUY7 A0A8C0TUY7_CANLF 4-hydroxy-2-oxoglutarate aldolase Canis lupus familiaris (Dog) (Canis familiaris) oxo-acid-lyase activity [GO:0016833] DWFGYYGGPCRAPLQELSPMDE;VGAVGGVCALANVLGA;VGGWASGEGRKVDIAGIYPP 3 17.8 0.85059 0.15117 0 0 0 6.95257 0 0 7.05778 5.08857 0 0 0 0 0 0 0 A0A8C0TUY8 A0A8C0TUY8_CANLF "Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)" TNNI2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; troponin complex [GO:0005861] actin binding [GO:0003779] DPYARVSLSTQAGHRH;DTPPTGLPWFLR;ESEKQNYLSE;VAVAAGVL;VGDWRKNIEEKSGM 5 11.3 0.98773 -0.46926 10.9551 10.7152 0 0 9.98385 11.6093 11.0404 11.1718 10.6989 0 0 0 0 8.71325 11.4311 A0A8C0TUZ1 A0A8C0TUZ1_CANLF Non-structural maintenance of chromosomes element 4 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]" EAVLDAQFLVLASD;EDPDTPMS;RPESAEAK 3 4.5 1.0029 -0.8561 0 7.77189 7.55382 0 0 0 0 0 8.47415 8.37864 10.3845 8.25224 0 0 7.74248 A0A8C0TV13 A0A8C0TV13_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ADCDACMCQDF;EGDHYDYNTVPFNEDDPMSWTEDY;HGAVSLPG;LEPRTGFSSN;PTLFAVSRRQKGPGEWTTW;SIVRGRVS;TACDLTCPMGQVNADCDACMCQD;VGHCPVKTCAGQQ 8 9.3 1.003 -2.4245 0 0 0 9.68897 6.8485 0 11.8206 8.34265 0 0 0 0 10.6283 0 0 A0A8C0TV33 A0A8C0TV33_CANLF Glutathione-dependent dehydroascorbate reductase (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Monomethylarsonic acid reductase) GSTO2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364] GGAVLLGL;ISMIDYLFWPWFERLEVYGI;RHEVININLRNKP 3 12.3 0.92582 0.10831 0 6.94228 0 0 0 8.66164 0 0 0 0 0 0 0 0 0 A0A8C0TV54 A0A8C0TV54_CANLF TIMELESS-interacting protein Canis lupus familiaris (Dog) (Canis familiaris) VPPKRTVKRNIPKLD 1 18.5 0.95706 0.053874 0 0 0 0 0 0 0 0 0 0 7.11676 0 0 0 0 A0A8C0TV58 A0A8C0TV58_CANLF START domain-containing protein LOC119873296 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525] FPHAPGERLHIPCLFC 1 6.3 0.98301 -0.24811 0 0 0 0 0 0 0 0 0 0 7.99729 0 0 0 0 A0A8C0TV65 A0A8C0TV65_CANLF Protogenin Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] plasma membrane [GO:0005886] GIAADTEH;VILDCQAHGEV;YTIRCNPV 3 2.4 1.0028 -2.5102 0 0 0 0 0 0 0 0 0 0 7.51072 0 0 7.15714 0 A0A8C0TV67 A0A8C0TV67_CANLF ADP-ribosylarginine hydrolase Canis lupus familiaris (Dog) (Canis familiaris) ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287] HYQDCMEDMDGRAPGECMQNA;SYFQDQWEKYLKLRGI;VKERDQFYT 3 12.7 0.97492 0.047166 0 0 0 0 0 0 0 0 0 7.16611 0 0 0 0 0 A0A8C0TV71 A0A8C0TV71_CANLF Myelin transcription factor 1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] IEADMMKLQTQITSM;KGAEIEVDENG;QELKCPTPGC;SCENMCDSETERRDPQNAH 4 5.8 0.99307 -0.1598 0 6.87246 0 7.86394 0 0 0 8.39746 0 0 0 0 0 0 4.35127 A0A8C0TV77 A0A8C0TV77_CANLF Phosphatidylinositol glycan anchor biosynthesis class T PIGT Canis lupus familiaris (Dog) (Canis familiaris) attachment of GPI anchor to protein [GO:0016255] GPI-anchor transamidase complex [GO:0042765] KTYAVYDLLDTAVI;NGELNTLLYNTHPYR 2 7.6 0.99203 -0.1841 0 9.75856 0 0 0 0 0 0 0 10.6684 0 0 0 0 0 A0A8C0TV90 A0A8C0TV90_CANLF Tetratricopeptide repeat domain 21B TTC21B Canis lupus familiaris (Dog) (Canis familiaris) ARNQLKRIAKMNWNPIDA;ETWVLFVNLH;LEMHQNYSGALEAV;LKRCLRHNKSCCK;VGEFNKLDTRFS;YKITLAFSRTCGRSQLILQKIQ 6 7.3 1.0038 -1.0545 0 6.37903 0 0 0 0 0 0 9.13484 0 0 0 11.9728 9.66162 8.7812 A0A8C0TV94 A0A8C0TV94_CANLF Condensin complex subunit 2 NCAPH Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] condensin complex [GO:0000796]; cytoplasm [GO:0005737] DEKMLSMLTKDL;DITTYGES;DVEESDCEDF;DVEESDCEDFP;EESDCEDFPDGPVE;IDPMFQKT;LYLKPGIRLL 7 9.6 1.003 -2.488 0 0 0 0 0 9.9508 0 0 0 6.14207 8.75024 8.71555 0 0 0 A0A8C0TVA9 A0A8C0TVA9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) KELVSKIYKEL;WNRIENPEVDPQLYGQL 2 4.2 0.98422 -0.25703 9.1876 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TVD3 A0A8C0TVD3_CANLF ADAM metallopeptidase domain 23 ADAM23 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] ADEDNTSQ;GVCSNEATCICDFTWAGTDCSI;IKQHADAVHLISYVTFH;KTYKKYRSSH;LLLVLLLLPPLATSSRPRAWGA;LSLESNDQWPFLSELQ;LVLLLLPPLA;TEYCTGDSGQCPPNLHKQDGYACNQ;TGRPHIIQKSLAGQYSKQMK 9 17.6 1.003 -1.6283 0 5.03927 0 9.70596 2.96529 0 0 9.62079 3.8023 0 10.1221 0 0 0 0 A0A8C0TVG3 A0A8C0TVG3_CANLF XPG N-terminal domain-containing protein ERCC5 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] nucleus [GO:0005634] endonuclease activity [GO:0004519]; single-stranded DNA binding [GO:0003697] EDDIYVLPPL;LFEAMPEVSL;TQVRREDDI;TTEKLLKTFLKRQAIKTALKSK 4 20.3 0.99825 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82302 A0A8C0TVH1 A0A8C0TVH1_CANLF Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) INO80 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to ionizing radiation [GO:0071479]; DNA-templated transcription [GO:0006351]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA repair [GO:0045739]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] cytosol [GO:0005829]; Ino80 complex [GO:0031011]; nuclear body [GO:0016604] alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787] AKLKKVKKKRRR;EADSQSEDNEEEEEE;EKKLKAKLKKVKKK;EKKLKAKLKKVKKKRR;FMLRRIKKDV;GGCTELAKPLYLQY;IEQLNARRR;KAKLKKVKKKRRR;KKELPKAN;KKLKAKLKKVKKK;KKLKAKLKKVKKKRRR;KLKAKLKKVKKKR;KLKAKLKKVKKKRRRDE;KLKAKLKKVKKKRRRDEEL;LKAKLKKVKKKRR;LPYWGNPHDRKVIRRFWSQKTLYTQ;MPAAGRGHSARS;PKKKKFKEEKKLKAKLKKVKKK;PYWGNPHDRK;QIDIGGGVVVNITQE;VLPYWGNPH 21 8.8 1.0013 -2.689 10.7136 6.96232 9.19106 0 5.03215 5.37917 4.42062 12.2449 10.7645 9.49327 7.5572 0 0 11.2374 0 A0A8C0TVH4 A0A8C0TVH4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IGPTLGAH;MTSTMAWSPLLLTLLAHCTA;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 8 25.4 0.99082 -0.13813 0 0 0 7.50184 0 0 0 9.68171 0 0 0 0 0 0 0 A0A8C0TVH8 A0A8C0TVH8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NVKHYNMVDK 1 4.3 0.98533 -0.24528 0 0 0 0 0 0 10.1161 0 0 0 0 0 0 0 0 A0A8C0TVI8 A0A8C0TVI8_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] EDTEFQEFLS;EEDLQRLFSKFGPLSE;LEGYYALDHV;QTKEPQDP 4 4.7 1.0028 -1.8863 0 0 10.6348 0 0 0 8.95327 0 9.4613 0 0 0 0 0 0 A0A8C0TVL9 A0A8C0TVL9_CANLF Cation channel sperm-associated auxiliary subunit delta (Transmembrane protein 146) CATSPERD Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] APLMWPDVPYQIL;NGLFTYTYSL;VYPVQVKEEPHTLLSSISE;WNTSIGIEHPVSHVSGDNCC 4 8 1.0027 -0.77967 0 0 10.729 9.21939 7.45171 0 0 0 0 0 10.6944 8.6453 0 0 0 A0A8C0TVM9 A0A8C0TVM9_CANLF SANT and BTB domain-containing protein SANBR Canis lupus familiaris (Dog) (Canis familiaris) LMAAGESPVE;RDKTWDVHEYLNSLFEELKSWRDVY 2 5.2 0.99313 -0.049358 9.30823 0 9.96421 0 0 0 0 0 0 0 0 0 9.83303 0 10.0105 A0A8C0TVN2 A0A8C0TVN2_CANLF Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA--protein transferase activity [GO:0004057] LSPSIVEYFEGED;PTVSQVRLVPVSFE;TFQESYQVYKRYQM;VGWRRRRRRGRVRSRRVWRAATM 4 10 0.90427 0.12271 0 0 0 4.81306 0 0 0 0 6.03049 0 0 0 0 6.97223 0 A0A8C0TVN6 A0A8C0TVN6_CANLF N-acetyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) histone acetyltransferase activity [GO:0004402] ATPSLLSEADLIPD;DFSAPGTP;EARRLKRKLIVRQAKRDRGL;FGFMVPDVKYNEAYISFLFVHPEWR;MLAMYNLSLEGSG;PSPSPSLDFSA;STECKHAFFLRLR;VLYKKVIIA 8 14.2 1.0031 -1.9214 10.0497 0 0 0 5.11524 0 7.91229 0 7.27324 6.21494 0 0 6.41649 0 0 A0A8C0TVS4 A0A8C0TVS4_CANLF SRY-box transcription factor 17 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DNA binding [GO:0003677] QSQTRSALP 1 2.2 1.0033 -0.80421 0 0 0 9.31297 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TVT2 A0A8C0TVT2_CANLF Ankyrin 2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; membrane [GO:0016020] EAFKQFGDFIDG;EDELNEILNGMDE;ESDQEQEEEIDM;GFGGDAPT;HYCEYTED;LEHLEDVPEALDQDDLQRDLQ;SVLQEELNTAQHKQKEEQGAS;SWTELARELDFTEEQIHQIRIEN;VVKKVTRKIIRRYVSS 9 6.4 0.95214 0.05044 0 5.42663 0 0 0 0 0 0 6.38745 0 0 0 0 0 0 A0A8C0TVU7 A0A8C0TVU7_CANLF BTB domain-containing protein KLHL41 Canis lupus familiaris (Dog) (Canis familiaris) regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014] cytoskeleton [GO:0005856]; M band [GO:0031430]; sarcoplasmic reticulum membrane [GO:0033017] VVGGLYVDEENKDQPLQ 1 3 0.97281 0.046736 0 0 0 0 0 8.72965 0 0 0 0 0 0 0 0 0 A0A8C0TVV0 A0A8C0TVV0_CANLF Arginine and glutamate rich 1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] cadherin binding [GO:0045296] DEKQKREEEEK;ESKRNRRRDR;ILEENNRKIAEAQA;KERVRKRSKSR;KRVEEELEKRKDEIEREVL 5 25.5 1.0021 -1.3615 0 0 0 7.50391 0 7.80155 10.5243 0 0 0 0 0 9.78973 0 0 A0A8C0TVX4 A0A8C0TVX4_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GVFIVFKLFTLVKLL;GVFIVFKLFTLVKLLV;GVFIVFKLFTLVKLLVLSFVIV;LTEEDYIKAGLNDTSSLGPLG;VASSQAGPATVIC 5 9.4 0.68027 0.2822 0 0 0 0 0 4.75184 0 0 0 0 0 0 0 4.22951 9.74125 A0A8C0TVX8 A0A8C0TVX8_CANLF Gamma-tubulin complex component Canis lupus familiaris (Dog) (Canis familiaris) microtubule nucleation [GO:0007020] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015] DGRYITAQPL;GHHTSFLDNCL;KAFNYASKVL;SGLEAFSFDYVVK 4 5.2 1.0025 -0.72432 0 0 11.2933 0 8.8431 8.90809 9.44514 0 0 9.80996 0 0 0 0 0 A0A8C0TVZ0 A0A8C0TVZ0_CANLF Methylsterol monooxygenase 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CFGCAESC 1 4.8 1.0034 -1.1044 0 0 0 0 0 0 8.97088 0 6.01859 0 0 0 0 0 0 A0A8C0TW03 A0A8C0TW03_CANLF Gamma-crystallin C (Gamma-C-crystallin) C37H2orf80 Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of eye lens [GO:0005212] GCWMLYEQPNYTGGQYFL;PIEEVFKIYGADSST 2 11.1 0.98314 -0.25599 0 8.79585 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TW11 A0A8C0TW11_CANLF Crystallin gamma C C37H2orf80 Canis lupus familiaris (Dog) (Canis familiaris) IVSFWCKF;PIEEVFKIYGADSST 2 11.7 0.98643 -0.45597 0 0 0 0 0 0 10.0771 0 0 0 0 0 0 0 0 A0A8C0TW35 A0A8C0TW35_CANLF C2 domain-containing protein SYT10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESIDLGEI;YVKMYLLPDRKKKFQTRVHR 2 5.7 0.98663 -0.45872 0 0 6.66491 0 6.76633 0 0 0 0 0 0 0 0 0 0 A0A8C0TW60 A0A8C0TW60_CANLF Serine aminopeptidase S33 domain-containing protein MGLL Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol metabolic process [GO:0006639] membrane [GO:0016020] acylglycerol lipase activity [GO:0047372] GERMVVSDFHVFIRDVLQHVDFMQK;PLPKLNSRH;TGPEDPFRMPEES 3 12.4 0.99217 -0.27195 0 0 0 0 0 0 0 0 10.9819 0 0 0 0 0 0 A0A8C0TW74 A0A8C0TW74_CANLF Fringe-like glycosyltransferase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375] AENLEKSGVSRKSDIDLK;GVSRKSDIDLKGIVFVI;TFHSFLPLCGNPV 3 7.2 0.9844 -0.24359 0 0 0 0 0 0 0 0 10.2233 0 0 0 0 0 0 A0A8C0TW76 A0A8C0TW76_CANLF Ig-like domain-containing protein LOC119869150 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] SVLTQPASVS;SVLTQPASVSG;TLTISVLQ 3 14.4 0.98844 -0.26074 0 0 0 7.69321 0 0 0 0 0 0 0 0 0 0 9.13137 A0A8C0TW94 A0A8C0TW94_CANLF Nuclear receptor interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712] DEYSDNNPSFTDDSSGDESSYSNC;NGCAGGAG 2 2.8 1.0035 -1.0631 0 0 0 0 0 0 0 0 0 0 7.91001 0 0 0 0 A0A8C0TWF8 A0A8C0TWF8_CANLF Bcl2 modifying factor Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] FYGNAGYR 1 4 1.0046 -1.1044 0 0 0 0 0 0 0 0 0 8.78558 0 0 0 0 0 A0A8C0TWF9 A0A8C0TWF9_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] AMWLVTAKMTHQ;RLPLQDVYKIG 2 8.6 0.99542 -0.19023 0 0 0 0 0 0 0 0 8.90132 0 0 0 0 0 0 A0A8C0TWH1 A0A8C0TWH1_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP25 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; regulation of protein stability [GO:0031647] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; SUMO binding [GO:0032183] AAQKHQQTFLNQ;EEYEEWHQDYRK;KSRNVYDRCGP;SPPSGSTPQTLPSTT;WLEDAFQMRAEEETDEEKPKNPMVE 5 7.1 0.98663 -0.38683 0 0 0 0 10.5195 0 0 10.9699 0 5.37243 0 0 0 7.76904 7.98925 A0A8C0TWN2 A0A8C0TWN2_CANLF Scaffold attachment factor B2 SAFB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] MEDRYRPDFPRPDHRFHDFDHRDRG;VIKKEEKMEKKEEKKPEDIKKE;WGGYASDKRMSEGRGPPPP 3 6.9 0.98288 -0.25198 0 0 0 0 0 0 0 0 9.12065 0 0 0 0 0 0 A0A8C0TWP2 A0A8C0TWP2_CANLF RH2 domain-containing protein SPAG9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] MAP-kinase scaffold activity [GO:0005078] GEYSDHNFFGMG;GIENKAFDRNTESLFE;QWKFQELSQPRSHTSLKD;SLLGGITVVGCSTEGV;VLMERNQYK 5 6 0.95216 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.50605 0 A0A8C0TWQ2 A0A8C0TWQ2_CANLF non-specific protein-tyrosine kinase (EC 2.7.10.2) Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; regulation of keratinocyte differentiation [GO:0045616] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] GEKDLHLFEKL;LEAQPTDMRAL;LLEAQPTDMRALQDFEE;PSLPLLPLLPLPLPPSL;TLWEMFTYGQ 5 5.8 0.9764 0.046227 0 0 0 0 0 0 0 0 0 0 7.539 0 0 0 0 A0A8C0TWQ7 A0A8C0TWQ7_CANLF CUE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin binding [GO:0043130] AARRVRVRVRVRVR;EEREGRREGRAGRRGS;EPDSSDEEPP;EVPKAEEALREGQ;LDDMEGHTCDEDF;LEGGGGGVYEDS 6 15.3 1.0029 -0.97923 0 0 7.48027 0 0 7.74207 0 0 0 0 0 8.90503 4.94303 0 6.80142 A0A8C0TWQ8 A0A8C0TWQ8_CANLF DNA repair protein complementing XP-G cells Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] nucleus [GO:0005634] endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] DGHYPWSCPVT;EDDIYVLPPL;LDDDEDMEAHAGND;LISCWNFLYSTM;LSSDDETECEKNCDS;NWQRFGLWNFP;SSSPKKKRLSDSKQERR;TKVKKKLRKLQLTPG;TQVRREDDI;TSSSSDDDGGGPVPV;TTEKLLKTFLKRQAIKTALKSK;VLVTARSVFGKRKGKLRGIRGKKRK 12 10.5 1.0001 -0.61446 0 10.9996 8.92982 5.23458 0 0 0 10.2435 0 8.64836 0 17.2529 0 5.91944 4.19944 A0A8C0TWS7 A0A8C0TWS7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KLFVLVLSL 1 10 1.0033 -0.80421 0 0 0 0 0 7.10003 0 0 0 0 0 0 0 7.20252 0 A0A8C0TWS8 A0A8C0TWS8_CANLF Glycosyl transferase CAP10 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] glycosyltransferase activity [GO:0016757] EPCSSQNCSCYHG;ILLSRKNPKLVDAEYTKNQAWK;QKESGSRWKVF;SSPCWTALAHLVICMRGGPPPTWS 4 6 0.98924 -0.31067 13.7192 0 0 0 0 0 9.75484 0 5.71864 3.86235 2.85886 0 0 0 0 A0A8C0TWT2 A0A8C0TWT2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;KLTLHIKKLEKKQQIDPT;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;WNQKRPRIARGILKKKTR 6 6.2 0.93141 0.096626 9.29297 0 0 0 0 0 0 0 0 0 0 0 5.304 6.27012 6.51155 A0A8C0TWV5 A0A8C0TWV5_CANLF UDENN domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] DLAEEIVMYMNNMS;GVAEKASKWYSR;GVAQFKRALKKQAHLS;KICYLDIGKPPLR;VLFEMQKAGIDPNAITYGYYNKAV 5 5.8 0.93747 0.059576 8.70477 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TWV6 A0A8C0TWV6_CANLF Solute carrier family 17 member 6 SLC17A6 Canis lupus familiaris (Dog) (Canis familiaris) "monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; regulation of synapse structure or activity [GO:0050803]; sodium ion transport [GO:0006814]; synaptic transmission, glutamatergic [GO:0035249]" cytoplasmic vesicle [GO:0031410]; excitatory synapse [GO:0060076]; plasma membrane [GO:0005886]; presynapse [GO:0098793] L-glutamate transmembrane transporter activity [GO:0005313]; neurotransmitter transmembrane transporter activity [GO:0005326] GCVIFVRILQGLVEGVT;LVSYESPAKHPTITDEERRYIE;VGFSGFAISGFNVNHLDIAPRY;YAIIVANFCRSWTFYL 4 13.9 0.98972 -0.2637 0 0 0 0 0 0 0 0 9.905 0 0 0 0 0 0 A0A8C0TWX6 A0A8C0TWX6_CANLF AF4/FMR2 C-terminal homology domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] AHSSSAESESTSDSDSS;DSDSSSDSESESSSSDSE;GKGSGSST;GPHPGRRSCPKSPAQQEALP;LQLSDSEDSDNEQS;PELKPLPEDYR;SNSKGYCPAKSPK 7 8.4 1.0025 -1.1241 0 0 0 0 8.14634 3.07668 8.66178 0 0 5.83845 0 0 10.0421 4.58598 0 A0A8C0TWY3 A0A8C0TWY3_CANLF U2 small nuclear RNA auxiliary factor 1 U2AF1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628] GGGGGGGG;PAPAPAPAHRAPARPAASP;PTPAPRAAREPRG;VGNVYVKFRREED 4 15.4 0.98887 -0.19792 0 0 0 7.85418 9.96996 0 0 0 0 0 0 0 0 0 0 A0A8C0TX05 A0A8C0TX05_CANLF Annexin Canis lupus familiaris (Dog) (Canis familiaris) cytokinetic process [GO:0032506]; phagocytosis [GO:0006909] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] LLPGPCPAPPPPRPGP;TVTPAVPPARFGNRG;YHDISVHP 3 4.5 1.0022 -1.1535 8.69968 0 0 0 0 0 8.76311 7.67709 0 0 8.57716 0 0 0 0 A0A8C0TX14 A0A8C0TX14_CANLF PA14 domain-containing protein B4GALNT3 Canis lupus familiaris (Dog) (Canis familiaris) AGEEGQVEGEEGEEEEEEEE;ALLLLLLRPVKL;ALLLLLLRPVKLL;ALLLLLLRPVKLLR;EEEEEEEEDMS;EEGEEEEEEEEEDMSEVFEYVP;GSPRAALLLLLLRPVKLLRRRF;LLLLLLRPVKLLRRR;LLLLLLRPVKLLRRRF;LLLLLLRPVKLLRRRFR;LLLLLRPVKLLRR;LLLLRPVKLLRRRFRLLLAL;LLLRPVKLLRRRFRLLL;LLLRPVKLLRRRFRLLLA;LLLRPVKLLRRRFRLLLAL;LLRRRFRLLLALALV;QRPVRLSEY;RAALLLLLLRPVKLLRRR;SPRAALLLLLLRPVKLLRRRFRLLL;TSLLESSIP 20 7.7 0.99135 0.00019655 0 0 0 0 0 0 0 0 10.4194 0 0 0 0 0 0 A0A8C0TX20 A0A8C0TX20_CANLF DDHD domain-containing protein SEC23IP Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] cytoplasm [GO:0005737] metal ion binding [GO:0046872] EEEPAEVRRCTWFYK;GAASTSSSG;RMGSDLKQGF;YVSIFEKEKI 4 4.7 1.0017 -1.2517 0 0 0 0 0 9.64633 0 0 0 10.2124 0 0 0 0 0 A0A8C0TX30 A0A8C0TX30_CANLF Neurturin NRTN Canis lupus familiaris (Dog) (Canis familiaris) system development [GO:0048731] extracellular region [GO:0005576] glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; receptor tyrosine kinase binding [GO:0030971] GAPDAVELRQ;LRRLRQRRRVRRERVRAQ;YDLGLRRLRQRRRVRRERVR 3 16.6 0.99297 -0.16273 5.20445 0 0 0 0 0 0 0 0 5.12259 0 0 0 0 11.9586 A0A8C0TX32 A0A8C0TX32_CANLF Hexosyltransferase (EC 2.4.1.-) CSGALNACT2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] EDEEQEDEDGPL;IEAGLEVINNPDEDEEQED;LLLGLALLCSLVLFLYLLE;NNPDEDEEQEDEDGPL;QIAQLKQELQEMSEKMRSL;TRTHWLLLGL;YPGCLWVERW 7 13.8 1.0031 -0.85031 0 9.75577 3.50208 0 0 13.0413 11.1156 0 14.3683 8.68678 3.99955 0 0 0 9.72744 A0A8C0TX44 A0A8C0TX44_CANLF dynamin GTPase (EC 3.6.5.5) LOC119868890 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653] membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] KSKPIPIMPASP;LARTLNRLL;QDTFLKGLKQKNGV;VELVHEEM 4 8.1 0.93811 0.060882 0 0 0 0 0 0 0 0 0 0 0 0 0 9.73405 0 A0A8C0TX79 A0A8C0TX79_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;VEQINRTKSWFF 4 6 0.78226 0.2299 0 11.3082 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TXB3 A0A8C0TXB3_CANLF EGF-like calcium-binding domain-containing protein CRTAC1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DIVYGNWNGPH;GPILSSSASDIF;GVTACDIDGDGRE;IFNFWFQMF;VGPDALIEMDPEASDLSQGIL;VLEIPYPRDADQLQDP 6 12.7 1.0018 -0.67078 2.93953 0 10.5384 8.86651 0 9.16825 0 0 3.72694 0 0 0 8.57543 0 9.65625 A0A8C0TXE6 A0A8C0TXE6_CANLF Phosphatidylinositol 4-kinase type 2 (EC 2.7.1.67) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] dendrite [GO:0030425]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524] GGGGGGGG;GGGGGRPG;RDCLVLNQGYLSEAGASL 3 5.8 0.97283 0.048313 0 0 0 0 0 0 10.8469 8.93047 0 0 0 0 0 0 0 A0A8C0TXH7 A0A8C0TXH7_CANLF Ceramide synthase 6 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] GVRFLKKTPWLWNTRHCWYNYP;LTTDLHYYYIL;VGLLPGAA;VLNTTLFESWEIVG 4 9.4 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.49036 A0A8C0TXK7 A0A8C0TXK7_CANLF phosphoinositide 5-phosphatase (EC 3.1.3.36) SYNJ1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] phosphatidylinositol phosphate phosphatase activity [GO:0052866]; RNA binding [GO:0003723] DLADKARALLTTGSLRASSK;GATGNKGA;GISLDLSLNAHRSMQ;GSLRASSK;MTFDDDWNKGTDV;QHLQPSSSSG 6 4.3 1.0041 -1.9979 7.46516 0 9.7489 0 8.66708 8.92724 0 0 0 0 11.9659 0 11.6744 0 0 A0A8C0TXN3 A0A8C0TXN3_CANLF Mannosyltransferase (EC 2.4.1.-) PIGZ Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] ACQVAGGPWLCRLF;LVLLCSPQTQPVPCK;QEARFLIPLLV;VPLFLWSICTATSP 4 9.1 1.0029 -0.9853 8.0908 9.57259 0 0 0 0 10.283 0 0 0 8.98763 0 0 0 0 A0A8C0TXQ4 A0A8C0TXQ4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; membrane [GO:0016020] small GTPase binding [GO:0031267] PAPDLNDPFFSFKVDL 1 9.1 0.99088 -0.22087 9.53749 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TXS1 A0A8C0TXS1_CANLF Kinase suppressor of ras 2 KSR2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] EVEPTSENEEGH;IIWQMGTGMKPNLSQ;LLEMTDEQVCE;VGHAPFLPSTPPVHT;VHTPKAKKKSKPL 5 7.2 0.98785 -0.22776 0 0 0 0 0 0 0 9.96369 9.77711 8.68755 0 7.91373 0 9.80205 9.41614 A0A8C0TXT3 A0A8C0TXT3_CANLF Maestro heat like repeat family member 2A MROH2A Canis lupus familiaris (Dog) (Canis familiaris) AEILGAILVH;HHYSSSCQDICL;KQMSAHHL;TLSTYKLTNHRESF 4 2.6 1.0027 -1.8518 0 0 0 0 9.2323 0 0 0 0 0 8.40667 0 10.5046 0 11.2514 A0A8C0TXU1 A0A8C0TXU1_CANLF Lactase like Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" ERYLQFCLGWFANPIYAGDYPQ;HMQMVTEIVVPT;RLGHRPHPQPEPSL 3 7 0.85502 0.15933 8.65353 0 0 0 0 0 0 8.60407 0 0 0 0 0 6.9514 0 A0A8C0TXU2 A0A8C0TXU2_CANLF Cell morphogenesis protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; neuron projection development [GO:0031175] cell cortex [GO:0005938]; site of polarized growth [GO:0030427] LLCSFQVATRKLSVLILKEIRAL;LNIFVKIIQ;LVLIEVLKQIPL;MLTNVQMLNKEPEDM;SGKWMSKTC 5 8.9 1.0034 -0.80421 0 0 6.43107 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TXW3 A0A8C0TXW3_CANLF DUF4200 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; intracellular non-membrane-bounded organelle [GO:0043232] DMIYNMSMI;KRQMFLIQ 2 2.9 1.0016 -1.414 6.99921 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TY25 A0A8C0TY25_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;LLKLFVKIERDGVL;MDAFLESHKL;MNEKGEITTNT;TSENEDTTVQNL 5 5.6 0.91463 0.11122 0 0 4.82304 0 6.87995 0 0 0 0 0 0 0 0 0 0 A0A8C0TY78 A0A8C0TY78_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AAVRAYDPAALCGLVW;AFLKQSGKFPGNPWPPYK;AGGACDCGDSNVMRESG;AMDVDSPENDIPMEI;ATGTLGQLDSSDEEDQ;AVHDVRLSLLQRYFK;CAECFHQGDHTGHDFNMFR;DVDSPENDIPMEI;HVLALHMRLYSI;LDIMVTVLLYMME;LDSSDEEDQDGSQ;MDVDSPENDIPME;MVTVLLYMMESCLI;SEYNPWRKLTQLVEEV;SGGASTAGK;VILRTVYRRD;VSVCGPERCH 17 11.1 1.0033 -1.9219 0 9.11359 6.84925 6.86071 6.88704 7.24031 7.24165 8.69342 15.0083 12.0351 8.44547 8.31863 11.6322 8.54373 9.26554 A0A8C0TY79 A0A8C0TY79_CANLF Voltage-dependent T-type calcium channel subunit alpha CACNA1G Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AEKDPGSADSEAEG;AEKDPGSADSEAEGLPYPALAP;DTLRDCDQESTCYNTV;EAELELEMKTLSPQ;KDPGSADSEAEGLPYPALA;LFFIFAAL;LGMLRVLRLLRTLRPLRVI;LMLPPPSTPALSGGPPGGA;LSNYIFTAV;LVHHLCTSHYLDL;RKKRLALVSLGEHPEL;RPASWLDEQRRHS;TENEDENPFICSQP;VGQQGGGL 14 7.2 0.98636 -0.41367 10.1882 10.7742 11.6277 0 10.4793 0 10.1263 0 6.06156 4.39739 0 9.04322 8.98177 10.4899 10.8715 A0A8C0TY87 A0A8C0TY87_CANLF DENN domain containing 4A Canis lupus familiaris (Dog) (Canis familiaris) ESCRT I complex [GO:0000813] guanyl-nucleotide exchange factor activity [GO:0005085] DLAEEIVMYMNNMS;GVAEKASKWYSR;GVAQFKRALKKQAHLS;PESVPLFCLPMGATIE;RGRDKPPL;RMLTWFIIKMNDVYGP;VLFEMQKAGIDPNAITYGYYNKAV 7 6.4 0.98935 0.020162 0 0 0 0 9.0398 0 10.5773 9.06894 8.26449 0 0 0 0 9.36109 9.789 A0A8C0TYB8 A0A8C0TYB8_CANLF Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein TACC2 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ALADLNSVE;ASFEIPASAIEANGV;DEVSKLSHDVESKVHSSTDSAQ;ELVDDFQTLE;EVPEPLDGGD;GNQGCGPEPASVPDGP;GPPEGCLASPVAAPEDWPLI;IEYMEKIGSSL;KPPDGAQGVAMAPL;LEPRCSDSSKSQECKV;LPQQSYNFDPD;PELQAAEGTATPLEPGS;PLDVVCLPTRGREEQASRS;QEAPRAPAAAQPGK;QPLQSEPEASIS;RHEEACLSDVGGSEAADAR;RVDAKEKKQELPTEAE;TEAEIPCLVPQDPAP;VESTSDTKMRSHP;VGTSDAQGHL;VKETQQEP 21 10.6 0.96318 0.049233 0 8.37994 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TYD0 A0A8C0TYD0_CANLF Tuftelin-interacting protein 11 TFIP11 Canis lupus familiaris (Dog) (Canis familiaris) biomineral tissue development [GO:0031214]; spliceosomal complex disassembly [GO:0000390] U2-type post-mRNA release spliceosomal complex [GO:0071008] nucleic acid binding [GO:0003676] FSDQVLAHPSVKDKF;LPELEHNLQLLI 2 3.2 0.98969 -0.20132 0 0 0 0 0 0 0 0 9.36232 0 0 0 0 0 8.21126 A0A8C0TYH0 A0A8C0TYH0_CANLF Spermatogenesis-associated protein 20 SPATA20 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] extracellular region [GO:0005576] AFQISGDEFYSDVAKGI;RAWLGRGLLLPRAARGLPARRR;RQVPPSAATMNSR;SVGYSTCHWCHMMEEE;VGGTYFPPE;VGYSTCHWCHMMEE;WLGRGLLLPRAARGLPA 7 9.8 0.93712 0.092926 0 0 0 9.92923 9.67421 0 0 0 0 0 4.48993 0 0 0 0 A0A8C0TYI8 A0A8C0TYI8_CANLF [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) NDST4 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] membrane [GO:0016020] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213] DIWSREKTCDHL;ESQYSQLGQDIIAILESSRFQ;PKRAASLVPKAKIITILI;PLPGEDWTIFQY;QLAHKYFELFPEQ;YPPMDPESRTFLSNYY 6 11.1 0.98658 -0.33196 6.47863 9.19925 7.04581 0 0 4.57894 0 8.87052 0 8.15183 0 8.38024 7.38612 7.89373 0 A0A8C0TYJ6 A0A8C0TYJ6_CANLF Solute carrier family 25 member 28 SLC25A28 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] mitochondrial inner membrane [GO:0005743] ALNSNITGHITGMASAFRTV 1 5.8 0.9894 -0.19713 0 0 0 0 0 0 10.1396 0 0 0 0 0 0 0 0 A0A8C0TYL7 A0A8C0TYL7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;IKILEKNTGKTLF;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.4 0.94015 0.059614 0 0 0 0 0 0 0 0 0 0 0 7.77906 0 0 0 A0A8C0TYM6 A0A8C0TYM6_CANLF Histone H2A/H2B/H3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] SAAIGALQEASEAYLVGLFE 1 15.5 0.95408 0.049371 0 0 8.02326 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TYM9 A0A8C0TYM9_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) LOC106559265 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] HHRINFDKYHPGYFGKVGMRHYHL;KLPKRPVVVKAK 2 28.3 0.95262 0.05044 0 0 0 5.35875 0 0 0 0 0 0 0 0 0 0 0 A0A8C0TYN9 A0A8C0TYN9_CANLF BTB domain-containing protein KBTBD12 Canis lupus familiaris (Dog) (Canis familiaris) EPDRLSNRLLQYDPSQDQWTDRA;HFAEVSLHEEILEIE;IGAEDLSDQSKKYLYQ 3 9.6 1.002 -0.67193 0 8.5315 9.66199 0 7.94626 0 0 8.49853 0 0 0 0 0 0 0 A0A8C0TYR2 A0A8C0TYR2_CANLF Phosphatidylinositol 4-kinase type 2 (EC 2.7.1.67) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] dendrite [GO:0030425]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734] 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524] RDCLVLNQGYLSEAGASL;WRRRRPAGPAP 2 6 0.99006 -0.26643 0 0 0 0 0 0 11.4313 0 0 0 0 0 0 0 0 A0A8C0TYV0 A0A8C0TYV0_CANLF ARID domain-containing protein ARID5A Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] transcription cis-regulatory region binding [GO:0000976] AGGEREEDQEREEEQ;LSESPQSPGK;LSSLPDRRKRQ;RLCPASSAWH 4 5.7 1.0035 -0.83041 0 0 0 0 0 0 9.40627 0 0 0 4.39191 0 0 0 0 A0A8C0TYV7 A0A8C0TYV7_CANLF Protein GRINL1A MYZAP Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] nucleus [GO:0005634] transcription elongation factor activity [GO:0003711] YKTSTGVYWCVRNYR 1 3.9 0.94938 0.053906 0 0 0 0 5.19365 0 0 0 0 0 0 0 8.44083 0 0 A0A8C0TZ41 A0A8C0TZ41_CANLF Cytochrome c oxidase copper chaperone COX11 COX11 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] copper ion binding [GO:0005507] AAVGMLGA;EQRLNPQEEVDMPV 2 8.2 1.0018 -1.3101 0 7.90002 10.2226 0 0 0 0 0 0 10.1976 10.241 11.1117 0 8.6744 0 A0A8C0TZ71 A0A8C0TZ71_CANLF Vacuolar protein sorting-associated protein 18 homolog Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872] ILDEYEDSLSRSAVLQ;LDARQLIPAL 2 2.7 0.99353 -0.16985 0 0 10.7435 0 0 0 0 10.4216 0 0 0 0 0 0 0 A0A8C0TZ76 A0A8C0TZ76_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF111 Canis lupus familiaris (Dog) (Canis familiaris) pattern specification process [GO:0007389]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; PML body [GO:0016605]; protein-containing complex [GO:0032991] SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630] DEDKEVSVRHSQ;DWFSQRKLHCKQDGEE;EDNDSSFSDCLSSPSSS;EVMQRMEVQ;HLFHQVCVDQ;PVHAFHSQ;QEQEKSVVVRKKRKSQQAGP;QKQKERILMQRKKREV;RQAPERSAWELGIE;VGESYRSRSTLGHS;YVIPHPVH 11 14.1 1.0031 -2.1263 10.1634 0 9.70373 0 0 0 10.903 0 8.52517 11.8002 0 11.0543 12.1703 0 0 A0A8C0TZ79 A0A8C0TZ79_CANLF Delta-like protein DLL4 Canis lupus familiaris (Dog) (Canis familiaris) developmental process [GO:0032502]; Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509] CSDNYYGDSCSRLC;DRCTSNPC;GSCRERSQGASYACE;GVDCELELSECDSNPCR 4 7.9 1.0018 -1.3087 3.7632 2.25154 0 0 0 0 4.2916 0 0 0 0 7.11145 0 0 0 A0A8C0TZB0 A0A8C0TZB0_CANLF START domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] AGVFVWDE;VLHWVTHFPYPMYSRDYVY;YSRDYVYVRRYSVDQENNVMVLV 3 11.6 0.99199 -0.16728 8.52156 0 0 0 0 0 0 0 9.91525 0 0 0 0 0 0 A0A8C0TZB3 A0A8C0TZB3_CANLF HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 HPS1 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] LDANVKENHCP;LYVLHLFGECLFIAINGD;STVDDDDPQ 3 5.9 1.0037 -1.0541 0 0 0 0 0 0 7.17223 0 0 0 0 0 0 6.80954 0 A0A8C0TZH2 A0A8C0TZH2_CANLF "RAD52 homolog, DNA repair protein" RAD52 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via homologous recombination [GO:0000724]; regulation of nucleotide-excision repair [GO:2000819] nucleus [GO:0005634]; protein-DNA complex [GO:0032993] identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697] EPSVEQARYSS;TAEEYQAIQNALRQR 2 6.4 0.99507 -0.12836 0 0 0 0 0 5.83441 0 0 0 8.23089 0 0 0 0 0 A0A8C0TZL6 A0A8C0TZL6_CANLF RAP domain-containing protein FASTKD1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitochondrial mRNA stability [GO:0044528] mitochondrion [GO:0005739] FEWNSMAL;QRFQQQLVNKTEHLFDTIDSSQVN;VECAFNILWQFQQQRTSFLKNVD;VKLRELLLRYLK 4 8.4 1.0017 -0.69281 9.89418 0 0 0 0 0 0 10.0864 0 0 0 0 0 0 0 A0A8C0TZS9 A0A8C0TZS9_CANLF Kinesin motor domain-containing protein KIF20B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DLAGSERTMKTQNE;INERKEKLTLE;ISKARKRKSNEMEGSSMFSSWWKSR;ISSPIDISG;KGCMDENNRLKIE;KVHELEKKKNQCSQEIDI;KYKAERKKWLEEKMMLII;LNFRDLSSGSQEDKH;NELQLEEPPAK;NNASSRSHSIFTI;PVLSKFQKRKILRLSQ;SPIDISGQVILMDHK;VLFDSLQE;VYVPDTLNSSQ 14 10.5 1.0031 -1.5031 0 0 0 8.3637 0 10.921 10.2783 11.4795 16.6978 0 7.51365 18.8733 10.8994 12.2669 0 A0A8C0TZV8 A0A8C0TZV8_CANLF ATP binding cassette subfamily C member 6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ISTIGLHDLRGK;LDNGSFKEGENMCI;LLRKTKILILDEATASIDFK;LVFVIPVNALVATRVKKLKNKDK;NMNKEAPWIM;YYVASSRQIRRLAGASRSPI 6 9.1 0.99181 -0.20856 0 0 0 0 0 0 0 0 0 0 11.114 10.2294 0 0 0 A0A8C0U056 A0A8C0U056_CANLF Aquaporin 9 AQP9 Canis lupus familiaris (Dog) (Canis familiaris) polyol transmembrane transport [GO:0015791] plasma membrane [GO:0005886] channel activity [GO:0015267] TAHIFATYPAPYLSLTNA 1 7.8 0.97658 0.048313 0 0 0 0 0 0 6.69766 0 0 0 0 0 0 0 0 A0A8C0U091 A0A8C0U091_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ;VGIEGTLLDILKAIYEK 4 4 0.98374 0.046227 0 0 0 0 0 0 0 4.29844 0 0 0 0 0 0 0 A0A8C0U0A5 A0A8C0U0A5_CANLF "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic)" DYNC1I2 Canis lupus familiaris (Dog) (Canis familiaris) transport along microtubule [GO:0010970] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] EAGKTANFMEKSL;EKKRKEEERKKKETDQK;ETDQKKEAVAPVQE;GSRTLHWDTDPSVLQLHSDSDLG;IVIYDVGE;SSKSVSTPSEAGSQDSGDGAV;SYETCGQCSQVANMSDKS;TPKPPIEPEEEKTLKKDEE;VGSRTLHWDTDPSVLQ;WNLNNDTEVPT;YSGRDLEDKEGEIQ 11 22.4 1.0025 -1.4014 0 8.38543 0 0 9.22161 7.47622 0 0 11.2722 9.41589 9.74747 0 5.87698 9.13804 0 A0A8C0U0A8 A0A8C0U0A8_CANLF Ig-like domain-containing protein CXADR Canis lupus familiaris (Dog) (Canis familiaris) adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] DLVCQDEHLSL;IFIKLPLCNDITKVRV 2 6.9 0.99407 -0.020493 0 0 0 0 2.23312 3.2468 0 11.9983 0 0 0 3.93847 0 0 0 A0A8C0U0E1 A0A8C0U0E1_CANLF Target of myb1 like 1 membrane trafficking protein TOM1L1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] KMNVRVMSAILMENIPGSENHE;SLIDMCMQNC;VNEDLNNALLGCE;WGQFMHICDIINTAH 4 12.7 1.0037 -1.0625 0 8.00579 0 0 0 0 9.1695 0 10.0661 0 0 0 0 0 0 A0A8C0YQX1 A0A8C0YQX1_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;YWRKNRHIDQWNRIENPEVDPELY 4 5.4 0.97405 0.041303 0 0 0 0 0 0 0 0 8.514 0 0 0 0 0 0 A0A8C0YR23 A0A8C0YR23_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled neurotensin receptor activity [GO:0016492] RARRLLSPRRTRRLLSLVWA;VICRMPYHVRRLMYCYISDD;VLSLALSALLLLLVCVPV 3 15.3 0.98658 -0.23517 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1149 0 A0A8C0YR29 A0A8C0YR29_CANLF L-dopachrome tautomerase (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) DCT Canis lupus familiaris (Dog) (Canis familiaris) melanin biosynthetic process [GO:0042438] melanosome membrane [GO:0033162] isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] PEEREQFLEALDLAKNTTHPDYVI 1 4.8 0.99339 -0.27907 0 0 0 0 0 13.5954 0 0 0 0 0 0 0 0 0 A0A8C0YR39 A0A8C0YR39_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;HWKKDSLFNKWCWVNWT;MDAFLESHKL;MNEKGEITTNT;PSICCLQETHFRQ 5 4.7 0.98352 0.046227 0 4.88431 0 0 0 0 0 0 0 0 5.88435 0 3.89647 0 0 A0A8C0YRL8 A0A8C0YRL8_CANLF EXPERA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] cholestenol delta-isomerase activity [GO:0047750] RVRSECPEGAPG;SPAPWGCGLGP 2 5.1 0.9957 -0.56561 0 0 0 0 0 0 0 0 0 8.89324 0 8.66718 0 0 0 A0A8C0YRN1 A0A8C0YRN1_CANLF MACPF domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) neuron migration [GO:0001764] membrane [GO:0016020] DDYDYEDDEDLPRRT;LLLLLLLL;LLLLLLLLP;LLLLLLLP;LSINPLAS;PPLLLLLL;PPLLLLLLL 7 2.7 0.98618 -0.45513 0 0 0 0 0 0 0 0 9.02331 0 0 0 0 0 0 A0A8C0YS72 A0A8C0YS72_CANLF Enoyl reductase (ER) domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] TLGRDVSGV;VISACEGVWTVE;VTVGSKALKHFW 3 8.6 0.99746 -0.10746 0 0 10.7552 0 11.3192 0 10.6296 0 0 10.924 11.1525 0 0 0 0 A0A8C0YS86 A0A8C0YS86_CANLF Myotubularin related protein 11 MTMR11 Canis lupus familiaris (Dog) (Canis familiaris) APVFLLFVDCV;LADQEWGL;NSVWLFSRGALT;NSYTQIYTPGYSQ;SANPQLSVWDWDLRYSS 5 9.5 1.0021 -1.8259 0 7.72267 9.90715 0 0 0 0 0 9.33168 0 0 0 0 0 9.14068 A0A8C0YS95 A0A8C0YS95_CANLF Actin-related protein 3 (Actin-like protein 3) Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314] actin cortical patch [GO:0030479]; Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; nucleus [GO:0005634] actin filament binding [GO:0051015] AGRACCLLAAASASR;AGRDITYFIQQLL;IDVGYERFLGPEI;PRHCACSLA;VIIRKRRI 5 8.6 1.0034 -2.2497 0 0 0 0 0 0 9.62298 0 12.3467 0 2.87267 0 0 8.34319 0 A0A8C0YSI4 A0A8C0YSI4_CANLF Family with sequence similarity 171 member B FAM171B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGLGRRVPGAV;ESFTQTLPKMPVH;PLLHTNGVSAGDHV;PVHSHAQP;QVNDIISRQ;SLPSQTSDWSRY;VLLCYCRDKCGTP 7 9.4 1.0041 -1.9937 0 9.78763 10.4242 0 0 0 0 0 0 9.60084 0 0 0 0 9.05167 A0A8C0YSQ4 A0A8C0YSQ4_CANLF "N-alpha-acetyltransferase 15, NatA auxiliary subunit" NAA15 Canis lupus familiaris (Dog) (Canis familiaris) NatA complex [GO:0031415] CHEIERHFI;LAFMPPGYEE;NLNEMQCMWFQTECAQAYKA 3 4.7 1.0024 -1.3675 3.31438 0 0 7.50359 8.07682 0 0 0 4.54523 8.59738 0 0 0 0 0 A0A8C0YST9 A0A8C0YST9_CANLF RIB43A domain with coiled-coils 2 RIBC2 Canis lupus familiaris (Dog) (Canis familiaris) DLALGKRRHN;IRLVQKQQIQEK;VPGWGRQETMPR 3 7.3 1.0025 -1.1871 9.52405 0 0 0 0 0 0 0 9.41861 0 0 0 0 0 0 A0A8C0YSY0 A0A8C0YSY0_CANLF Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1) LTB Canis lupus familiaris (Dog) (Canis familiaris) humoral immune response [GO:0006959] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164] GVLRKLRFTYIKI;LSKGVLRKLRFTYI;PSLSKGVLRKLRFTYIKISR 3 9.9 0.85817 0.16854 6.96636 5.75689 6.58332 0 0 0 0 0 0 0 0 0 9.75258 0 0 A0A8C0YT87 A0A8C0YT87_CANLF Coiled-coil serine rich protein 2 CCSER2 Canis lupus familiaris (Dog) (Canis familiaris) EDDDLMLDVDLPED;KPSVSNSLVPPPVSESSPSRTPTC;LPLFKPSVSNS;NLISPDTDYR;PGEEFPVGIVL;TDEWIDISV 6 7.4 0.98862 -0.22496 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4987 0 A0A8C0YTA3 A0A8C0YTA3_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] SPATLEAP;SPQELQLHYFKMHD;VGLDKNTVHDQ 3 10.7 1.0005 -0.63249 0 0 0 9.43471 0 0 0 0 10.1015 0 0 0 0 8.45496 0 A0A8C0YTC3 A0A8C0YTC3_CANLF Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (SET domain bifurcated 2) SETDB2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] chromosome [GO:0005694]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; protein-lysine N-methyltransferase activity [GO:0016279]; zinc ion binding [GO:0008270] FTDSCDCSEGC;IFEQVQNVLQSLK;LFTDNFSFNTYVQ;TELTWDYGYEAG;TVWPRAYY 5 8.3 1.0019 -1.2302 0 0 6.31709 5.96738 0 0 0 0 4.70194 0 8.24413 0 7.68811 5.81796 0 A0A8C0YTE1 A0A8C0YTE1_CANLF Proline rich nuclear receptor coactivator 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ALPMVTTAPPPLP;LPPTLFLPHFLGG;PSRFHQYQQHRPSLE 3 13.8 0.92755 0.10635 12.3653 0 0 0 0 0 0 10.8232 10.8201 0 0 0 0 0 14.2178 A0A8C0YTF2 A0A8C0YTF2_CANLF 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) PIKFYVE Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; phosphatidylinositol metabolic process [GO:0046488] 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] CVSPWPSYQCPSMFC;ELQFSDANAKFYCRLYYAGE;GRDDTSNELVVGIIDYIR;IPSDAVWSTKVDCLNP;LPFTPLGWHHNNLE;PHVPPHPA;VCVPLPKIFIKRQVPLKVSLLQ 7 5.4 1.0026 -1.162 8.27547 0 0 6.08006 0 0 0 6.3187 9.12138 0 0 0 0 9.48202 0 A0A8C0YTL3 A0A8C0YTL3_CANLF Kallikrein related peptidase 11 KLK11 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] AKEPGACPSPLQ;MFALVTGHVRAET;TLRCANITIINHEECEKA 3 15.5 0.98967 -0.20079 0 0 0 0 0 0 0 0 0 0 0 0 10.0396 0 0 A0A8C0YTM9 A0A8C0YTM9_CANLF Nuclear receptor binding SET domain protein 3 NSD3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; N-methyltransferase activity [GO:0008170]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] DTSDSDSRGLSDLQICE;ECLSIEMPEGCWNCNDC;ISDSCKPL;KRRKIKAEPKQ;PPPYKHIKANK;VSEKPREEPVPK;WECPWHQCEEC 7 6.3 1.0031 -1.7334 0 0 0 0 0 0 12.8516 0 10.1946 5.68544 0 8.31886 6.77083 0 0 A0A8C0YTN2 A0A8C0YTN2_CANLF NACHT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGSPSWDAGNVQRLL;GVEALVHDLC;IESDDQDPTNNRP;RPFSSVTDTKE 4 6.9 0.98938 -0.51832 0 0 0 0 0 7.37217 0 0 0 8.74809 0 6.47996 0 0 0 A0A8C0YTP1 A0A8C0YTP1_CANLF Replication factor C subunit 2 RFC2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EADSMTDGAQQALRRTMEI;FINSENVFKVQEPMGPRWFCKAG;LVMVGGQHWEPLDR 3 14.5 0.85663 0.1683 0 0 0 0 0 0 0 9.40412 10.5367 0 0 0 9.26704 6.71754 0 A0A8C0YTQ3 A0A8C0YTQ3_CANLF Sulfatase N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) arylsulfatase activity [GO:0004065] MIAKWGCSP;PSVTPCCNP;SLAHKYAEKAIQFI 3 6.2 1.0032 -1.328 0 0 10.2851 0 0 0 7.28188 0 0 0 0 0 6.59525 0 0 A0A8C0YTT8 A0A8C0YTT8_CANLF Leiomodin 3 LMOD3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] striated muscle thin filament [GO:0005865] tropomyosin binding [GO:0005523] AEEDEGDEDDEDDDEEDE;AEEDEGDEDDEDDDEEDED;AEEDEGDEDDEDDDEEDEDG;AEEDEGDEDDEDDDEEDEDGE;DEGDEDDEDDDEEDEDGEE;EDEGDEDDEDD;EDEGDEDDEDDDEEDE;EEQKQQQLKEQRKLI;EGDEDDEDDDEEDEDGEES;EGDEDDEDDDEEDEDGEESV;EGDEDDEDDDEEDEDGEESVEKPQR;EPAEEDEGDEDDEDDDEED;GDEDDEDDDEEDEDGEESVEKPQ;HKSLMDYMYWQKASRRMLEDERVP;NDVQEPAEEDEGDEDDEDDDE 15 13.2 0.53608 0.42076 7.83731 0 0 7.39223 0 0 8.09334 0 0 7.98031 3.99077 0 0 8.82944 4.96454 A0A8C0YTU6 A0A8C0YTU6_CANLF ABC transporter domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ALCGARGPGIP;ASGGLAHLGLRQCADRPAGT;GVDPASRHSIWELL;IDMVRNQAMADAF;LLLLLLYGWS;LSRLLWRRLKPLVL;SRLLWRRLKPLVLGKLLF;VCTLNNTC;VPPGLTPG 9 4.9 1.0038 -2.0401 0 2.77857 8.5194 8.14277 0 10.8022 0 0 0 0 0 0 12.1452 10.0041 5.22203 A0A8C0YTV6 A0A8C0YTV6_CANLF Clarin 2 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] membrane [GO:0016020] DLVNATDPELVKFIGDIYYGLFRG;LFLALALALVSMGFA;VPYRAVNGPG 3 21.2 0.99172 -0.18314 0 0 0 0 0 0 0 0 9.36497 0 0 0 0 11.3704 0 A0A8C0YTW5 A0A8C0YTW5_CANLF "WD repeat domain, phosphoinositide interacting 1" Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site [GO:0000407] lipid binding [GO:0008289] TVPDGMLSPNHLSPPRR 1 4 0.95804 0.051259 0 0 10.2025 0 0 0 0 0 0 0 0 0 0 9.96651 9.74828 A0A8C0YU18 A0A8C0YU18_CANLF KIAA0930 KIAA0930 Canis lupus familiaris (Dog) (Canis familiaris) AARMAQKMSFGFYKYNNMEFVR;TDPGVHAVPGSGS;YFMEKWAPRQDDMLFYVRRK 3 11 0.99488 -0.15678 7.41177 7.43771 0 0 0 7.48454 0 0 11.7116 0 0 0 0 0 0 A0A8C0YU22 A0A8C0YU22_CANLF ABC transporter domain-containing protein ABCA15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GTLLLTRKLLII;HIVMVKEAHCNVEEIFKLLQY;IPVYWLSALLWD;METDHMLAAFNLLDKHNA;QVKSRVGYCPQSDALLE;VIILLMCMIFFV;VPMIFPGAWEL 7 6.8 0.99217 -0.28878 0 0 0 0 12.542 0 0 0 11.1514 0 10.5015 0 0 9.72775 8.88573 A0A8C0YU58 A0A8C0YU58_CANLF MHD domain-containing protein FCHO1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905] DLELVGSGYRMSLV;GQTHTPKAMGK;KALLGSYAHSV;LVHTSAIEHYQPN;TLSGVDLELV 5 6.1 1.003 -1.5184 0 0 9.651 0 0 0 0 0 10.98 0 0 0 0 8.33307 6.71795 A0A8C0YU59 A0A8C0YU59_CANLF Fibrillar collagen NC1 domain-containing protein COL24A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] ETKLLLHF;LFSIRNKNRLQLGVQLLPKKL;YETDLYDYYYYYED 3 2.5 1.0015 -0.99645 0 0 5.04264 0 0 5.35421 0 0 0 0 0 0 8.71963 0 0 A0A8C0YU80 A0A8C0YU80_CANLF Adenosylhomocysteinase (EC 3.13.2.1) AHCYL2 Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] hydrolase activity [GO:0016787] ESEDDFWWCIDRCVNVEG;IGRRSLSRSIS;KRAQGEKPLAGAK;LTELTDEQAKYL 4 10.6 1.0023 -0.97118 14.374 14.8104 14.7885 0 0 12.7094 0 12.5197 0 0 0 0 0 0 0 A0A8C0YU82 A0A8C0YU82_CANLF Serine/threonine-protein kinase 11-interacting protein STK11IP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AVCPHCGS;GRLQCLRCGQEF;VPRVGPSGV 3 2.9 1.0019 -1.3086 0 0 0 7.61824 0 0 0 9.3012 9.2609 0 0 0 0 0 0 A0A8C0YUA5 A0A8C0YUA5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA-type intron splice site recognition and cleavage [GO:0000379] tRNA-intron endonuclease activity [GO:0000213] VPPLLSQG 1 3.7 1.004 -1.1044 0 0 0 0 3.45273 0 0 0 0 0 0 0 0 0 0 A0A8C0YUA8 A0A8C0YUA8_CANLF Transcription factor 4 TCF4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERLSYPSHSSADINSSLPPM;NHAVGPSTAMPGGHGDMHG;YFFFFFCEVGGGGV 3 6.7 0.98511 -0.43097 0 0 0 0 0 0 0 9.98527 0 0 0 0 0 9.84472 0 A0A8C0YUE0 A0A8C0YUE0_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] GLRNQSAVTGFLL;LCNDKAISYSAAMAYDRYVAICS;LYHVIMSPRACSLLV 3 17.5 0.98693 -0.35589 0 0 0 0 0 0 10.5629 0 11.4688 4.03931 0 0 0 0 0 A0A8C0YUE1 A0A8C0YUE1_CANLF Alpha-mannosidase (EC 3.2.1.-) Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] EHVTHRVRLYNIQGI;GPGSPGLPQGPAP;GYSALLLI;IQDAKHRLTLLSAQSLGVS;PIDPAAASPRLLPP;PPARRAEGGG;QYIFNNMVI;RRRRRRRRRRTKAFRGLLPAGA;SFLVQIPPLGLK 9 9.4 1.0025 -1.3691 9.98114 13.8667 0 0 8.43095 8.47921 9.54753 10.0378 9.22067 0 5.21409 0 0 0 0 A0A8C0YUF1 A0A8C0YUF1_CANLF Piezo non-specific cation channel R-Ras-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] mechanosensitive monoatomic ion channel activity [GO:0008381] EKEDITVAELE;FNKFMKGAMQFLENYE;SEKRYPQP;VKCVYFGLSAY 4 7.5 0.9632 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0753 A0A8C0YUG8 A0A8C0YUG8_CANLF AT-rich interactive domain-containing protein 3 (ARID domain-containing protein) Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677] APGKGGGG;DEEDEDEEEEEDYED;DEEEEEDYEDEEVLGP;EDEDEEEE;EEEDYEDEEVLGPL;EQFKQLYE;GKGGGGRG;LDLFMLYVLVTEKGGL;TSAAFTLRTQYMKYLYPYECEKRGL;WEEEEEEEELEEDLEED 10 16.3 1.0028 -2.5326 10.2671 0 11.0296 13.1411 0 0 0 11.988 13.3511 12.4651 10.0543 12.2544 0 12.9877 0 A0A8C0YUL5 A0A8C0YUL5_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DEMLCAGD;PAGGTQRLAP 2 4.5 1.0031 -0.8722 0 0 0 0 0 0 10.4687 0 0 0 7.07735 6.88362 0 0 0 A0A8C0YUM5 A0A8C0YUM5_CANLF Fork-head domain-containing protein FOXJ3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GMECIISGSASPTLAI;KDSLCGQMGL;LPPDDIQDDFDWDSI;LRMTSELESSLT;LSEIYQWICDNFPYY;PQHPSPHQHIQHHPNHQHQTL;PVTNHPEPVSQSLTPQ;QSLASVNLNSVGSVH 8 16.1 1.0027 -1.51 0 0 0 0 11.0842 0 0 3.8675 10.9838 0 0 0 0 0 8.95423 A0A8C0YUN4 A0A8C0YUN4_CANLF Adhesion G protein-coupled receptor G5 ADGRG5 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] ERMVRSRSSISLP;LSCLTWMAIE;PALLVLLLL;SNFYLQLH;YHAEAEAEAEMEAFSSSQTM 5 9.5 1.0008 -2.7271 0 10.4899 0 0 7.5227 0 10.3749 0 0 9.77447 6.17517 0 0 0 0 A0A8C0YUQ3 A0A8C0YUQ3_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein ADGRG5 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] LSCLTWMAIE;PALLVLLLL;SLALSLIRDLECSLLN;YHAEAEAEAEMEAFSSSQTM 4 10.8 0.96233 0.049233 0 0 0 0 0 0 0 0 5.88762 0 0 0 0 0 0 A0A8C0YUQ7 A0A8C0YUQ7_CANLF Receptor interacting serine/threonine kinase 1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; cellular response to cytokine stimulus [GO:0071345]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response [GO:0031349]; response to stress [GO:0006950] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] CARKLGFTEP;EQQLILCIKSG;NIQNPGVKGLPYSIATNPGNAVHQ;YTGPKRTEYNESLLE 4 6.8 0.98529 -0.4485 10.3264 0 0 9.75551 0 0 0 0 0 0 0 0 0 0 7.19012 A0A8C0YUR8 A0A8C0YUR8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VKDERNKERVNQEIDFPSINKGMC 1 18.3 0.97385 0.041303 10.4484 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YUW3 A0A8C0YUW3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) REQCFSFGHRKWCLQHS 1 65.4 0.98266 0.046227 0 0 0 0 9.16616 0 0 0 0 0 0 0 0 0 0 A0A8C0YUW7 A0A8C0YUW7_CANLF Globin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) hemoglobin complex [GO:0005833] heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ADALTTAVAHLD;AHGKKVADALTTAVAHLD;ALSALSDLHA;ALSALSDLHAYKL;ALTTAVAH;ALTTAVAHL;ALTTAVAHLD;ALTTAVAHLDDLPG;ALTTAVAHLDDLPGAL;AVAHLDDLPGAL;DALTTAVAHL;DALTTAVAHLD;DKFFTAVSTVLTSKY;DKFFTAVSTVLTSKYR;DKIGGHAGDYG;DKIGGHAGDYGGEAL;DLPGALSALSDLHAYKL;DLPGALSALSDLHAYKLRVD;DPVNFKLL;DRTFQSFPTTKTYFPHF;DRTFQSFPTTKTYFPHFDLSPG;DRTFQSFPTTKTYFPHFDLSPGSA;EALDRTFQ;FDLSPGSAQV;FFTAVSTVLTSKY;FPHFDLSPG;FPHFDLSPGSA;FPHFDLSPGSAQV;FPTTKTYFPHFD;FPTTKTYFPHFDLSPGSAQV;FTAVSTVLTSKY;FTAVSTVLTSKYR;GEALDRTF;GEALDRTFQ;GEALDRTFQSF;GGEALDRTFQ;GGEALDRTFQSF;GHAGDYGGEAL;GHAGDYGGEALD;GHAGDYGGEALDRTFQ;HAGDYGGEAL;HAGDYGGEALD;HFDLSPGSA;HFDLSPGSAQV;IGGHAGDYGGEALD;KIGGHAGDYGGEALD;KKVADALTT;LPGALSALSDLHAYKLRVD;LTTAVAHLD;PHFDLSPGSAQV;PTTKTYFPHFDLSPGSAQV;PVNFKLLSH;RTFQSFPTT;RTFQSFPTTKTYFPHFDLSPGSAQV;SALSDLHA;SALSDLHAYKLRVD;SCGPCSPTPT;SDLHAYKLRVD;SFPTTKTYFPHFDLSPG;SFPTTKTYFPHFDLSPGSAQV;SLDKFFTAV;SLDKFFTAVST;TAVSTVLTSKY;TAVSTVLTSKYR;TFQSFPTTKTYFPHFD;TPAVHASLDKFFTAVSTVLTSKYR;TTAVAHLD;TTAVAHLDDLPG;TTKTYFPHFDLSPGSAQV;TYFPHFDL;TYFPHFDLSPG;TYFPHFDLSPGSAQV;VAHLDDLPGAL;VDPVNFKLL;VSTVLTSKY;VSTVLTSKYR;WPLSPPSGP;YFPHFDLSPGSAQV;YGGEALDRTF 79 44.9 1.0027 -1.1227 0 0 0 9.92646 0 0 0 6.94416 0 10.318 0 0 10.6604 0 0 A0A8C0YUX0 A0A8C0YUX0_CANLF Negative elongation factor complex member B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] DPHPGRLPHSPSP;GWGCPAAL;LHNFFSPSPKARRQ;QETLPRDS 4 4.9 1.0036 -1.6047 8.15198 0 10.4102 10.3079 10.244 10.3234 0 4.67909 2.15776 10.6885 10.6689 11.0453 9.20882 4.64737 0 A0A8C0YUX4 A0A8C0YUX4_CANLF PHD-type domain-containing protein PHF21B Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AVKKCLELKTSLLARQ;ELKTSLLA;FVPPPSPGTQ;RRVRTAGP 4 5.6 1.0019 -1.2592 11.279 11.3874 11.5148 0 0 9.24325 11.5248 11.4874 10.4415 0 10.8498 0 11.8917 12.0717 11.5553 A0A8C0YUY1 A0A8C0YUY1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CDC42BPA Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] CFSVETLL;CHITCVNKAPTAC;DWWSLGVCMY;EEGLFVVH;GGMDQGSDAPARDYDGEDSDS;LTTLYENVSMRN;NVSMRNQQL;SFMTLRNPRPQES;SLGVCMYEML;SVAHWEAQITEIIQWVSDE 10 5.9 1.0037 -1.1044 8.12184 0 0 0 0 0 8.11244 0 0 0 0 0 0 0 0 A0A8C0YV01 A0A8C0YV01_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ESGGDLVKPG;EVQLGESGGDLVKPG;SGGDLVKPG;VRQAPGKGLQ 4 21.7 0.67974 0.27664 0 0 0 0 0 0 0 0 0 9.01134 0 0 0 0 0 A0A8C0YV04 A0A8C0YV04_CANLF Replication factor A C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230] DNA binding [GO:0003677] ISASACPR;LEEIVSGSQDCDPEI;LSSICGPE;VIDYFHQLLQ;YSDHEGSYDASA 5 5.6 1.0035 -1.6344 0 0 0 0 0 0 11.3832 0 11.2303 5.55772 0 0 0 9.51258 0 A0A8C0YV12 A0A8C0YV12_CANLF LIM interaction domain-containing protein LDB2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] LIM domain binding [GO:0030274] KDSLSFRRWCGLPSNQ;RLITRLENTQ;TIRQYRELV 3 10.1 1.0017 -0.91407 8.37998 0 0 11.4459 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YV27 A0A8C0YV27_CANLF Sulfurtransferase TST Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] thiosulfate sulfurtransferase activity [GO:0004792] EECRNTASPYEMMLPSEAHFA;GAAAARAF;PANFSGGQGRAPGRRRGRVMR;VLDASWYSPGTRE 4 14.1 1.0034 -1.5531 7.82998 0 0 0 0 0 9.78875 0 9.86739 0 0 0 0 8.57735 0 A0A8C0YV45 A0A8C0YV45_CANLF Prolylcarboxypeptidase Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type exopeptidase activity [GO:0070008] AGAVAMGR;IFSNGELDPWSGG;IGGSYGGM;VSCGVFMEIVTTDFKKS 4 7.3 1.0026 -0.72895 11.8408 11.9792 0 0 0 0 12.1457 0 0 6.71026 0 0 10.8664 11.0089 10.796 A0A8C0YV46 A0A8C0YV46_CANLF "Alanine--glyoxylate aminotransferase 2, mitochondrial (EC 2.6.1.18) (EC 2.6.1.40) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-3-aminoisobutyrate-pyruvate aminotransferase) (D-AIBAT) (D-beta-aminoisobutyrate-pyruvate aminotransferase)" AGXT2 Canis lupus familiaris (Dog) (Canis familiaris) pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] LLLHQGHKEWLFDYEG;RERGGLCIADEVI;VNEIHDNC 3 8.5 1.0027 -0.84738 0 0 0 0 10.2784 0 0 0 0 0 0 0 0 0 9.50361 A0A8C0YVA3 A0A8C0YVA3_CANLF Tigger transposable element derived 6 TIGD6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] HLLKQILLKL;RSHLLKQILLKLR 2 2.5 1.0035 -0.89077 0 0 0 0 0 0 0 0 5.39702 0 9.15588 0 0 0 0 A0A8C0YVB4 A0A8C0YVB4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGE;GGGGGGGG;RLPGPQAAMT 3 4.8 1 -0.61146 0 0 0 0 8.03678 0 0 0 0 0 0 0 0 0 0 A0A8C0YVE8 A0A8C0YVE8_CANLF LRRNT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] IDLRHNEIYEI;PPSALARLRFLEELRL;SIPEKAFVGNPSLITMTLNG;SPLCLALPP;VIEMPYAYQCCVFGVCEN 5 8.7 1.0042 -0.82188 0 0 0 0 9.05167 8.21252 14.5903 9.24372 0 0 0 0 0 0 0 A0A8C0YVI2 A0A8C0YVI2_CANLF DEUBAD domain-containing protein ASXL3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GCGAFCHDDC;IVCKGCGAFCHDDC;MSNLPLTSEASPV;PLKMGSSIVPEA;QSKSMKSPTSPEPDFC;RKRENHPKKRVARTVGE;TGPVGTTVRAALGCRESGA;TLSLTVSIESAEASLDL;VLFFFFSFFF 9 5.3 0.98503 -0.44769 0 8.93216 5.45723 0 5.0106 0 0 0 0 0 10.2119 0 11.4179 6.63278 0 A0A8C0YVI7 A0A8C0YVI7_CANLF NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) NDOR1 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] perinuclear region of cytoplasm [GO:0048471] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958] LESLSNKLWALR;PQGQEELYSY;VAVVQYQTRLKE 3 4.8 0.99018 -0.21543 0 0 0 0 0 6.52682 7.19938 0 0 0 0 0 0 0 0 A0A8C0YVJ8 A0A8C0YVJ8_CANLF Synapse differentiation inducing 1 like Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] LYSYLLGGAGSA;PGQVEEDI;QENDQEEEEESDMTSTDSESEDNFV 3 18.8 1.0022 -1.0184 0 6.66249 0 9.58703 0 9.51363 0 10.3974 0 0 10.1882 0 0 0 5.85497 A0A8C0YVM9 A0A8C0YVM9_CANLF "Pleckstrin homology, MyTH4 and FERM domain containing H1" PLEKHH1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] CDSDEDYEAG;DARIEEVDRSCDSDEDYE;EEPENVEMEEQP;GEGDPDSP;RLNQETGMRKSSHSGFALFTDD;YRSHEDKRPL 6 5.7 1.0027 -2.1803 0 8.98242 6.32079 0 5.08181 0 6.54492 0 0 7.96238 10.7531 0 0 0 0 A0A8C0YVP0 A0A8C0YVP0_CANLF Chimaerin (Chimerin) CHN2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] IDAEEYQPP;IHDLVTDG;VDICIREIE;YCANFMWGLIAQGVR 4 8.8 1.0017 -0.70325 8.15548 12.3289 12.109 0 0 0 0 9.78006 10.3098 12.1013 12.3749 12.0932 11.5415 11.6406 0 A0A8C0YVR3 A0A8C0YVR3_CANLF Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAGLALSLTKF;GSDDSHGEEGQ;LCSWFRVVPRDREARR;YFYYYLFRFSAALGQ 4 11.9 0.98406 -0.24206 0 0 0 0 0 0 0 0 0 10.5997 0 0 0 0 0 A0A8C0YVS2 A0A8C0YVS2_CANLF TROVE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; RNA binding [GO:0003723] ILMAMSQIPA 1 1.9 0.98533 -0.25858 0 0 8.40126 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YVT9 A0A8C0YVT9_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ELKVEPHPSTLSVQEGN 1 11.1 0.98244 0.046227 0 0 0 0 5.89905 0 0 0 0 0 0 0 0 0 0 A0A8C0YVU5 A0A8C0YVU5_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) PHYKPGEPGVWGSLSSTA;SEEPDLTAGAGTEG;SVAVVTAFMMKTDQLTFEKAYESLQ 3 12.1 0.98569 -0.23667 0 0 0 0 0 0 0 0 0 0 0 0 9.55449 0 0 A0A8C0YVV4 A0A8C0YVV4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAEVVLSGNTVDVV;AGDVVPSGDTVNVVL;DILSSGEAVD;DVVPSGDSVDVVTSGEVVDVVVS;NADVVTSGDTVDVV;SEDTIDVVMSGEAV;SGDVNVLMSGDNVDVVPLG;SVVLSGEAADVVPSGDTVDVVMS;TVDMVTSREDVDV;VLSGNTVDVVMSGKAVD;VMSGVVDVLVSGDAVAVV 11 12.6 1.0029 -0.87825 14.8027 11.0965 11.2562 0 0 6.02186 9.39391 0 9.24707 13.7654 8.14517 7.4876 7.95687 0 14.9438 A0A8C0YVV7 A0A8C0YVV7_CANLF Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8) SLC5A8 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324] transmembrane transporter activity [GO:0022857] WISQGMSVL 1 1.6 0.98313 -0.25595 0 0 0 0 0 0 0 0 11.7261 0 0 0 0 0 0 A0A8C0YVY5 A0A8C0YVY5_CANLF Large ribosomal subunit protein eL36 (60S ribosomal protein L36) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] LPRLKKDS;VGPFKDKWALKVIKKRSRLT 2 24.6 1.0032 -1.0562 0 0 6.38191 0 0 0 0 0 0 5.34993 0 0 0 0 0 A0A8C0YVZ4 A0A8C0YVZ4_CANLF Succinyl-CoA:3-ketoacid-coenzyme A transferase (EC 2.8.3.5) OXCT1 Canis lupus familiaris (Dog) (Canis familiaris) ketone body catabolic process [GO:0046952] mitochondrion [GO:0005739] CoA-transferase activity [GO:0008410]; nucleic acid binding [GO:0003676] NLTMLGAMQV;QVREFNGQHF;SGSGNFGG 3 5.9 1.0023 -1.2229 0 0 0 0 0 0 10.649 0 0 0 0 0 0 4.1776 0 A0A8C0YW20 A0A8C0YW20_CANLF Coiled-coil domain containing 162 Canis lupus familiaris (Dog) (Canis familiaris) DVMARERSNF;ISSQSFLPPKGASEIE;LQKMIDSLQSPQDPTE;SNFESYSMCYEHVL 4 5.9 1.0029 -0.84117 0 4.59759 0 0 0 0 0 7.87258 0 0 0 0 0 0 0 A0A8C0YW40 A0A8C0YW40_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109] RDRKFREEEQLLQEREEQLRRQEH 1 4.2 0.97364 0.041303 0 0 0 0 0 0 11.3989 0 0 0 0 0 0 0 0 A0A8C0YW53 A0A8C0YW53_CANLF Myosin binding protein C2 MYBPC2 Canis lupus familiaris (Dog) (Canis familiaris) DEGRYTIKVTNPVGEDVASI;SEPLHLMVEDVTDTTT;TIKWFKGK;VGEDWAILVW 4 4.7 0.98772 -0.50456 0 9.22427 0 0 0 0 0 0 0 0 0 8.53037 0 0 0 A0A8C0YW71 A0A8C0YW71_CANLF Septin Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; spermatogenesis [GO:0007283] cell division site [GO:0032153]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; septin complex [GO:0031105]; septin ring [GO:0005940] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] DNSNCWQPVI;EMKKMEKENSVAYNEVT 2 6.3 0.98723 -0.50213 0 0 0 0 0 0 0 0 0 12.7049 0 0 0 0 0 A0A8C0YWA3 A0A8C0YWA3_CANLF Centriolin CNTRL Canis lupus familiaris (Dog) (Canis familiaris) ALQEQHEVNISLQQTQGDLSAY;ENALQEQHEVNISLQQTQGDLS;ENMRKELAELENALQ;ESVISGLQEYLETVKGQA;EVEELHRTIQ;FENVLEEIAELRREVS;KIEKVDKLLKLRELNLSYNKIRK;KKLKSLRILNLKGNKISSL;KTLSQTKRQLSERE;LGLDRELKKLKKA;LNLSLAKGGGKKFRCIENL;MKINQERAEELQETE;PPRPRTPGSREGASMRE;PPSSHSPSPPSL;QEDHPFVPPPGYMMYTVF;QESMVQAKADLQEA;QHKMEQEEILKEINKV;SEQTRLEKDVGEWTK;VGVLHCNVPEHHN 19 11.3 1.0023 -0.64913 9.82818 7.11447 0 12.7818 6.06063 0 10.957 7.84775 0 0 0 0 9.37508 10.0892 11.7365 A0A8C0YWC2 A0A8C0YWC2_CANLF CD99 molecule (Xg blood group) Canis lupus familiaris (Dog) (Canis familiaris) homotypic cell-cell adhesion [GO:0034109]; positive regulation of neutrophil extravasation [GO:2000391]; T cell extravasation [GO:0072683] membrane [GO:0016020] GGGGGGGG;KNQQSTNAEQPVQWTLLE;PVGSLGAVGGPP 3 12.5 0.99127 -0.19476 0 0 0 0 0 9.26336 10.7403 0 0 0 0 0 0 0 0 A0A8C0YWD0 A0A8C0YWD0_CANLF E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; protein ubiquitination [GO:0016567]; regulation of signaling [GO:0023051] calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; ubiquitin-protein transferase activity [GO:0004842] AAEDQRENRDQADG 1 2.9 0.93367 0.068213 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16.7446 A0A8C0YWD8 A0A8C0YWD8_CANLF Phosphorylase b kinase regulatory subunit PHKA1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] plasma membrane [GO:0005886] calmodulin binding [GO:0005516] AFPLCLKLP;CLCAVLHLGSREGIRSFRFF;EVDASLLSVI;GIDLMSPSFLSPGP;QVSILAETEE;TPQFIDQQQFYLALD;VLADEVQHCQSI;VPPDKVDEEYQNPHTVDRVPMGKLP 8 8.8 1.004 -1.9992 6.14806 0 0 7.27696 9.87906 0 13.441 0 0 0 0 0 0 0 0 A0A8C0YWF6 A0A8C0YWF6_CANLF Phospholipase A2 (EC 3.1.1.4) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid catabolic process [GO:0009395] cytosol [GO:0005829] calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]; phospholipase activity [GO:0004620] EVPKSQWSH;HLCLLDTAFFVN;LEQGHVDIYG;LLTVKVIRMKVRQAD;YKVTFTDFWGLLIEACLG 5 7.4 1.0045 -1.0437 0 0 5.24998 0 0 0 0 10.4348 0 0 0 0 0 0 9.74157 A0A8C0YWG8 A0A8C0YWG8_CANLF C2 calcium dependent domain containing 4C C2CD4C Canis lupus familiaris (Dog) (Canis familiaris) ARRRLTRRA;GATKANGGDGVPR;KLQKQRSTIIKNSRH 3 7.8 0.99832 -0.60449 0 0 0 0 0 0 0 0 0 0 3.53032 0 9.67074 0 0 A0A8C0YWL4 A0A8C0YWL4_CANLF Small nuclear ribonucleoprotein U11/U12 subunit 35 SNRNP35 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] IDQHEIFVD;PPSSCSIGGTDADH 2 10.2 0.9957 -0.56567 0 0 11.9634 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YWM0 A0A8C0YWM0_CANLF Toll-like receptor 2 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670] transmembrane signaling receptor activity [GO:0004888] EAGGNNFLCSCEFLS;GVCDGRSRSLN;LILPQLKELSISRNKLKTL;LKELSISRNKLKTLPD;RDVCYDAFVSY;SEHDSYWVENLLVQK;SPELRGRLGHSLRP;TARLPASECHRTAL;TLILRQNRLKS;YKSLGETPLFSQL 10 12.9 1.0022 -1.2666 13.0153 8.40032 0 7.17692 0 0 7.29591 0 0 0 0 9.98214 9.16897 0 0 A0A8C0YWN9 A0A8C0YWN9_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; Z disc [GO:0030018] metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AEGFHEKDKKPYCRKDF;FQNPNLPKKKKKKKKSKKEKKRK;FQNPNLPKKKKKKKKSKKEKKRKR;KKKKKKKK;KKKKKKKSKKEKKRKR;KKKKKKKSKKEKKRKRN;LPKKKKKKKKSKK;LPKKKKKKKKSKKE;LPKKKKKKKKSKKEKKRKRNSPNQ;NLPKKKKKKKKSKK;PECFVCGDCFSSFSSGSFF;PKKKKKKKKSKKEKKRKRN;PNLPKKKKKKKKSKKEKK;TSETVSVQNDPSPLPVQLV 14 17.9 0.29104 0.64853 0 7.06016 0 0 0 6.91791 8.02691 9.69822 5.67098 7.38024 9.58073 7.97154 7.27808 5.65561 0 A0A8C0YWQ0 A0A8C0YWQ0_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] external side of plasma membrane [GO:0009897] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493] ASLRPQDQGWELGLELP;GPGSETSPELEE;LPACAGSRPPPSPSP;SAKALCALLWACAALASLPN 4 8.7 0.9946 -0.13085 0 0 0 0 0 11.049 0 0 0 0 0 0 0 8.45668 6.40858 A0A8C0YWQ2 A0A8C0YWQ2_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] GAQPAVSGTGEETV;MCLCTDFL;TESHGSYSSGNDIGPFGERD;TVTRFRGMI;VGVWNAVTQHWQV 5 8 0.98882 -0.31809 0 0 0 0 0 0 0 6.85237 10.9009 0 0 0 11.053 0 0 A0A8C0YWR0 A0A8C0YWR0_CANLF Testis expressed 50 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KKVKHRKLKRKSRGE;LENQSIYD;PAKKVKHRKLKRK 3 14.1 0.99243 -0.14871 0 0 0 0 0 0 6.07671 0 5.99195 6.3538 0 9.06644 0 0 0 A0A8C0YWR7 A0A8C0YWR7_CANLF Gem nuclear organelle associated protein 8 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal snRNP assembly [GO:0000387] SMN complex [GO:0032797] YFAQTERHREERRRQ 1 6.5 0.98394 -0.24378 0 0 0 0 0 0 9.5769 0 0 0 0 0 0 0 0 A0A8C0YWS5 A0A8C0YWS5_CANLF Phospholipase A2 (EC 3.1.1.4) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid catabolic process [GO:0009395] cytosol [GO:0005829] calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]; phospholipase activity [GO:0004620] SPERLASYRQELE;TELSVRLRSSE;VEFSPYEVGFPKYGAFVP 3 5.2 0.86387 0.16079 10.7583 0 0 0 0 9.38657 0 0 0 0 0 0 0 0 8.8141 A0A8C0YWV2 A0A8C0YWV2_CANLF Voltage-dependent anion-selective channel protein 3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] LDTIFVPN;PSGSLMQDSIP 2 10.5 1.0039 -1.0689 0 0 0 0 0 0 0 9.46451 0 0 0 0 0 8.77647 0 A0A8C0YWV5 A0A8C0YWV5_CANLF Olfactory receptor OR5B32 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;HYATIMTSAMYTSLA 2 8.9 0.9476 0.055294 0 0 10.1317 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YWW6 A0A8C0YWW6_CANLF F-box protein 11 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511] zinc ion binding [GO:0008270] AGIEITNHATATLEGNQIF;KSAQHHNAHH;SHPVLRKNRIF 3 4.5 0.99448 -0.17297 11.2649 0 0 0 0 0 0 0 0 10.9261 4.79665 0 0 0 0 A0A8C0YWW9 A0A8C0YWW9_CANLF Olfactory receptor OR5B12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TEFILVGLTNEPKLQI;TTIMTTGECARLVIGCYICGFL 2 12.1 0.93782 0.097296 0 0 0 8.00473 0 0 0 0 7.4245 0 0 0 0 0 0 A0A8C0YWX2 A0A8C0YWX2_CANLF D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) LDHD Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] catalytic activity [GO:0003824]; FAD binding [GO:0071949] ETMRQLKAMLDPQGLM;QLNCPVAPTLFLEFH;TLFLEFHGSE 3 7 1.0025 -1.1505 7.50136 0 0 0 0 9.33396 0 0 0 0 0 0 0 0 0 A0A8C0YWX3 A0A8C0YWX3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mRNA processing [GO:0050684]; spliceosomal complex assembly [GO:0000245] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGECLRHPWLN;APQQKPIGKISKNKKKKLKK;DDEDDEEEDCPNPEEYNLDEPNAE;DEDDEEEDCPNPEEY;DFLIPMLEMVPE;IGKISKNKKKKLKKKQ;IHVCMVFEVL;ISKNKKKKLKKK;ISKNKKKKLKKKQKR;KKLKKKQK;KKLKKKQKRQAELL;KNKKKKLKKKQK;KNKKKKLKKKQKRQAELLEKRLQEI;KPIGKISKNKKKKLKKK;KSIIRQVLQGL;LDDEDDEEEDC;LLPAGGAS;NKKKKLKKKQKRQAELLEK;PREQRQRRRRRRRRRGGRL;PTPPEPEEEILGS;QQLDDEDDEEEDC;RKGELRHI 22 17.2 1.0038 -1.055 0 0 0 9.03502 0 0 0 0 0 0 0 8.38392 0 0 0 A0A8C0YX05 A0A8C0YX05_CANLF Kinesin light chain KLC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] DLFPNDDDDPGQ;GVSSGASL;NKPIWMHAEERE 3 5.1 1.0043 -1.0539 0 0 5.87958 0 0 0 0 10.5937 0 0 0 0 0 0 0 A0A8C0YX17 A0A8C0YX17_CANLF Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (KLRAQ motif-containing protein 1) STON1 Canis lupus familiaris (Dog) (Canis familiaris) early endosome [GO:0005769] RNA binding [GO:0003723] EARRWWPS;ETSARAALE;GVVDEQANSAALKEQL;KFSQYLHENASYVRPLEEGMLHLFE;LLQDELALSEPRGK;RKPLLESVPYE;TCCGAGAG 7 10.3 0.98122 0.035491 0 0 10.1746 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YX40 A0A8C0YX40_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGHSSGAAMWPGADVKIHN;AVADGWYILQ;SLDNMTIYDSE;TIYDSEFWEEATPIWITN 4 10.9 1.0041 -1.084 0 0 0 8.64954 5.67737 8.73545 0 0 9.84238 0 0 0 9.61303 0 0 A0A8C0YX72 A0A8C0YX72_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM45 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GVEFTEHLLT;TIDHLAMNDVML;VVPKDKKDSP 3 5.8 0.98535 -0.43035 0 0 0 9.78467 0 0 0 8.59399 0 0 0 0 0 0 0 A0A8C0YX93 A0A8C0YX93_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LPVTPENKRKVLGKALALIRFP;PVDVTLGE 2 3.7 0.98734 -0.46342 0 0 0 0 0 0 0 0 0 0 4.50309 0 0 0 0 A0A8C0YX97 A0A8C0YX97_CANLF RWD domain-containing protein WDR59 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; Seh1-associated complex [GO:0035859] DFPKSRRWKSKREG;LETPWARHPF;QLVTWSRDQTLRMWRVDSQMQRLCA;QQFDDFKKCYGEILYRWGLREKRA;SSGSCSSMSDPGLNA;TAVEYLAAHLS;VISDLDWAV 7 11.5 1.0028 -2.5633 0 0 0 9.79839 0 0 0 0 10.1525 0 0 0 10.1616 0 0 A0A8C0YXA9 A0A8C0YXA9_CANLF Protein HGH1 homolog Canis lupus familiaris (Dog) (Canis familiaris) EVQVPEDVERQLQRLDQQEQEQHSR;GASGGPEAGAEAEVATLLPF 2 11.3 0.94833 0.05015 0 0 7.76481 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YXB8 A0A8C0YXB8_CANLF Methyltransferase type 12 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] cytoplasm [GO:0005737] RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] FKKGQCLSENFYVRGD;GGTSGSGVMADPYPECALAAVGE;NEFYKIHENGFFKDRHWLFTEFPE 3 13.3 0.99466 -0.16416 7.10664 0 13.5707 0 0 0 0 0 0 0 0 0 0 0 8.62363 A0A8C0YXC6 A0A8C0YXC6_CANLF Phospholipase (EC 3.1.4.4) Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] CLSLDSYRRIGFY;FQEFHRELLKYKAFIRI;RELLKYKAFIRIPIPTR;SLDSYRRI 4 3.1 1.0014 -0.95219 7.12732 0 0 0 4.16414 0 0 6.21193 0 0 0 0 7.32553 0 0 A0A8C0YXD2 A0A8C0YXD2_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ESPQEEASP;LSDSYWSGLGLGFKLSSSERR;MKREEYDDPLQKPLD 3 4.4 1.0022 -1.0197 9.81381 9.60494 0 0 0 0 0 0 0 0 0 7.65227 0 0 0 A0A8C0YXD4 A0A8C0YXD4_CANLF Keratin 28 KRT28 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] DGNSCSKS;EIDQRGKVLS 2 3.9 1.002 -1.4232 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.64386 A0A8C0YXF4 A0A8C0YXF4_CANLF Band 7 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GGGSLGALEGVL;GGRGRSLGLGPGSPPSIPRG;LSDREEIAH;PVRPPSSR;VLGTKNLSQILSDREEIAHN 5 10.1 0.94137 0.10043 5.55477 0 0 0 0 0 0 0 9.23376 0 0 0 0 0 6.45309 A0A8C0YXF9 A0A8C0YXF9_CANLF Zinc finger protein 512 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] KDNSFQYTI;KRKPRQEEDEDYREF;LCHINSRPQCSIKD;RQEEDEDYREF 4 7.4 0.98807 -0.47169 0 11.5696 9.39483 0 0 0 0 0 0 10.3626 0 0 0 7.97499 0 A0A8C0YXG2 A0A8C0YXG2_CANLF E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) CBLL1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] HMSHIPPKQH;KHHMSHIPPKQHIMMPP;TLSPPFTQP 3 5.3 1.0024 -1.0224 0 0 0 8.62377 0 0 0 0 0 0 8.5557 0 8.05658 0 0 A0A8C0YXG6 A0A8C0YXG6_CANLF "Keratin, type I cytoskeletal 10 (Cytokeratin-10) (Keratin-10)" KRT10 Canis lupus familiaris (Dog) (Canis familiaris) epidermis development [GO:0008544]; epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] GGFSGGSFGGYGGGYGGDGGLLSGN;GGGGGGGG;GGGSSGGGYGGSSGGGYGGS;SSSKGSIGGGF;SSSRCGGG 5 12.3 0 1.3206 0 0 0 9.96469 0 0 0 11.0229 10.2989 0 5.50297 0 10.2014 0 0 A0A8C0YXH0 A0A8C0YXH0_CANLF NIPA like domain containing 2 NIPAL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] KHMVILLTLVALLASLTVI 1 5.5 0.94943 0.04956 0 0 0 0 0 0 0 0 0 0 0 5.34749 0 0 0 A0A8C0YXH7 A0A8C0YXH7_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSL4 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] membrane [GO:0016020] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] DINCVKHIIYVDNKTIN;ELPWLYCYSYCC;LATMKLRLNVLTII;SEENEMQPN;TYGCRIGYSSPLTLSDQEIMDRIY 5 9.2 0.98984 -0.26397 0 0 0 6.04472 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YXI6 A0A8C0YXI6_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) UBE3C Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] AGVGRAHAG;DSASEEALTLMAS;ISIHDNEFFGDPIEVVG;LKSRDTRRNFCPPNH;QDSASDSEDEGEEADK;VLQTFLSQLPVS;VSPASTSCQDSASDSEDEG 7 6.9 1.0026 -0.71921 0 4.68611 0 8.06517 7.90725 0 0 10.6737 0 0 0 0 0 0 10.7997 A0A8C0YXJ1 A0A8C0YXJ1_CANLF Complement C1q like 1 C1QL1 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322]; regulation of synapse pruning [GO:1905806] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synaptic cleft [GO:0043083] signaling receptor binding [GO:0005102] GGKAHGGN;VLVVLIPVLVSSGGP 2 8.9 0.95013 0.053874 0 0 0 0 0 0 6.90147 0 0 0 0 0 0 0 0 A0A8C0YXJ5 A0A8C0YXJ5_CANLF Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) SLC26A4 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transmembrane transport [GO:0098661] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] IRVYNKRLKALRKIQKLIK;LEPLQKSVLAAVV;NDAFEPDEDTEDPED;VGFDAIRVYNKRLKALRKIQ 4 7 0.80247 0.21106 0 4.68801 0 5.90771 0 5.42122 0 5.5697 0 0 0 0 0 0 0 A0A8C0YXK8 A0A8C0YXK8_CANLF Solute carrier family 12 member 3 SLC12A3 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324] chloride:monoatomic cation symporter activity [GO:0015377]; metal ion transmembrane transporter activity [GO:0046873] AELNTIAPIISNFFLCSYA;ALAFDTRPSHEMTDGLV;GVVLFLLLYVIYKKPDVN;IGVVLFLLLYVIYKKPDVNW;IVEEHGTPIVDPINDIRI 5 7 0.85479 0.15185 0 0 0 0 0 13.9478 0 5.70487 5.55044 0 0 0 0 7.70079 0 A0A8C0YXM7 A0A8C0YXM7_CANLF Biorientation of chromosomes in cell division 1 like 1 Canis lupus familiaris (Dog) (Canis familiaris) AGCMGADA;DEEEEEEEEDEPSG;ETTTPQERSMSNDDGE;EVEQSSPG;KEEISNSRKDNTEALRDYSV;KRKKHYPSSEDELDDNPDVLDSKI;KTAVVACKSGRG;LISTSIAEECEA;SSPGSKPKLTQTDESNK;SSRPERKLSDGHKSRSFKHGSK;SVSEATEDKKDQESD;TGITEEDGEGPASCTG;VLNDELRTST;VTSTGITEEDGEGPAS 14 6.3 0.99686 -4.4033 7.802 12.6596 5.57568 0 0 9.31624 0 0 6.81057 0 0 0 6.40369 9.37584 0 A0A8C0YXP4 A0A8C0YXP4_CANLF "Glycerol-3-phosphate dehydrogenase, mitochondrial (EC 1.1.5.3)" GPD2 Canis lupus familiaris (Dog) (Canis familiaris) glycerol-3-phosphate metabolic process [GO:0006072] mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] DDFSSGTSSRS;GSGSRPTSEARGAEVGQPERAG;NAAACCPPANQRGQGSGS;RGQGSGSRPIREARGAEVGQP 4 3.5 0.99663 -0.11259 0 0 0 0 0 0 0 0 0 0 0 0 0 8.78362 0 A0A8C0YXP7 A0A8C0YXP7_CANLF Uveal autoantigen with coiled-coil domains and ankyrin repeats Canis lupus familiaris (Dog) (Canis familiaris) AAQGHMDE;EQFRRDEGKLVEENK;HQVKSLQQ;KQLEMEKLLLEN;LTSKNQVLQ;NRNILFFFCFPFQCTSPGVPAHMQ;QENDKLKKEIFTLQK;TRNQILSMMNCWFSC;VLATQMCRPAI 9 8.4 0.97456 0.041303 0 0 8.79588 7.61934 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YXR2 A0A8C0YXR2_CANLF "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" SUCLA2 Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775] EINPMVEDSDG;RGRGGEGRGGEGGGREGGREGGA 2 5.6 0.99296 -0.17929 0 0 0 0 0 0 10.0215 0 10.2868 0 0 0 0 0 0 A0A8C0YXR6 A0A8C0YXR6_CANLF F-box protein 31 FBXO31 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] DLMHRIQLPDVESLRNFN;EEFRTWLREEWGRTLEDI;GPGSAAHA;RRRRRGWSPAPAWRC;SATVECMYGHRGP;VGKGKGPA 6 12.7 0.98979 -0.21204 0 0 0 0 0 5.43879 8.99002 0 0 0 0 5.13105 0 11.0238 0 A0A8C0YXS5 A0A8C0YXS5_CANLF Conserved oligomeric Golgi complex subunit 5 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intra-Golgi vesicle-mediated transport [GO:0006891] Golgi transport complex [GO:0017119] AAERDRKRRKKLKVKGGQRLSPL;DECYSDFLNEDFDVKTY;GAAAATVRELLQDECYSDFLNEDF;LSPLGFPGSVL;VHQPSAPPNSVL 5 19 0.99088 -0.19584 0 9.71617 0 0 0 0 0 0 0 0 0 0 0 5.20097 0 A0A8C0YXT7 A0A8C0YXT7_CANLF Acetyl-CoA acyltransferase 2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] acetyl-CoA C-acyltransferase activity [GO:0003988] FAPQYLAVEKSLDLDPS;VGYFVSGCDP;VTFHICHL 3 8.7 1.0035 -1.0341 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.3815 A0A8C0YXT8 A0A8C0YXT8_CANLF Olfactory receptor OR4A15 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EFVLLGLTQDLEGQKFLFIP;FIYQLPFCGPN 2 9.8 0.99116 -0.19577 0 0 0 0 0 0 7.75181 0 0 0 0 9.26139 0 0 0 A0A8C0YXU5 A0A8C0YXU5_CANLF USP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] EHSWGREKYYP;ETSTPGPEESPAEG;HSRNRGGSDQDWSRY;ITQALSNP;KKHKKSKKKKKSKDKHRSR;KKKKKKKK;LENPNKPVPSSTVTNS;LQNLGNTCFANAALQCLTYTPP;MFVINEMRRIARHFR;MSQPNGEPIIYVLYAVLVHTGFNC;PEESPAEGPGAEM;QATTLVCQIFGGYL;SCSKPVMNGKSKLNSSVL;YMLSHEHSKTCHAEGFC;YSSSSVPD 15 16.2 0.99841 -3.2866 9.37925 10.3345 0 0 5.26765 6.18846 0 7.62505 9.42555 8.31075 5.86389 9.87689 0 5.46679 10.3953 A0A8C0YXU9 A0A8C0YXU9_CANLF Large ribosomal subunit protein uL15/eL18 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; rough endoplasmic reticulum [GO:0005791] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] QDIYLRLLVKVVLKRLFMSRTNRPP 1 14.5 0.97868 0.035538 0 0 0 0 0 0 0 0 6.44578 0 0 0 0 0 0 A0A8C0YXX2 A0A8C0YXX2_CANLF Transmembrane protein 164 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPGAGGPP;LFPVVNTRLLP;LMTMTHGKLVILFSYMAG 3 8.4 1.0019 -1.2097 10.1601 0 0 7.69565 0 5.76392 9.9405 0 0 0 0 0 0 0 0 A0A8C0YXX7 A0A8C0YXX7_CANLF Bromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DAPGEDEEEDG;EMDNEPPVSESDD;RCAIEADMKMK;VIKETQEKYRRLKR 4 5.8 0.98801 -0.22552 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9206 0 A0A8C0YXY2 A0A8C0YXY2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;RMGNINKAGNNKCW;TVEQINRTRSWSFERI 5 5.4 0.9625 0.049233 0 0 0 0 0 0 0 7.54466 0 0 0 0 0 0 0 A0A8C0YXY4 A0A8C0YXY4_CANLF Anosmin 1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] AASGGCLA;CVESCEADNECSG;LVWCQNHKQ;SKSLVPTKKKRRKTTD;TELQSGQLEIKWSSKFNIS;TPDLTLPSGHRPHLKHRHPPHYKPS 6 13.4 0.97574 0.035538 0 0 0 0 0 0 0 0 8.60951 0 0 0 0 0 0 A0A8C0YXY8 A0A8C0YXY8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MARCHF10 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ILSRKRRPKLGTLIVSP;LSMSSTFIHSA;QECLKKWLKVKITSGADLGAVKTC;SRFNVRRPLS;TEPPPLGPRV 5 9 1.0039 -1.0402 0 0 0 0 0 0 10.3129 0 0 12.1915 0 0 6.58855 0 5.71724 A0A8C0YXZ4 A0A8C0YXZ4_CANLF Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] RLLLLLLL;VLPRLLLLLL 2 4.1 0.99825 -0.61146 0 0 0 0 0 0 0 6.02959 0 0 0 0 0 0 0 A0A8C0YY03 A0A8C0YY03_CANLF PH domain-containing protein PLEKHD1 Canis lupus familiaris (Dog) (Canis familiaris) EQAESDALDISTKVQ;NDSECGGGWRRARPEWA;PLGGCLVEAKE 3 5.8 0.99236 -0.19339 0 9.50142 0 0 0 0 0 0 0 0 0 0 5.85147 0 0 A0A8C0YY04 A0A8C0YY04_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SDFSLTIHGV 1 7.1 0.99971 -0.61146 0 0 0 0 0 0 0 0 0 0 8.61456 0 0 0 0 A0A8C0YY10 A0A8C0YY10_CANLF Zinc finger protein 483 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] NKMTTISP;VISQEENP;VLRRTESLES 3 10.7 0.98491 -0.25872 0 0 0 10.6071 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YY15 A0A8C0YY15_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)" PLCB3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] AVQDDTAKVWA;CFEMSSFV;EEEEEEEQADPKKPTSDEGTASS;GLEKPSLEPQKSLG 4 4.8 1.0023 -0.72326 10.2602 0 0 0 0 0 0 0 0 0 0 5.93133 10.4325 0 10.4515 A0A8C0YY22 A0A8C0YY22_CANLF PUM-HD domain-containing protein PUM2 Canis lupus familiaris (Dog) (Canis familiaris) miRNA processing [GO:0035196]; regulation of mRNA stability [GO:0043488] cytosol [GO:0005829] mRNA 3'-UTR binding [GO:0003730] GFGSSSSL;GLGVSMVEYV;IVEFSQDQHGSRF;YVVQKMID 4 4.2 0.99388 -0.17263 0 0 0 0 0 0 0 0 0 0 0 0 11.2098 0 0 A0A8C0YY25 A0A8C0YY25_CANLF Protein-serine/threonine kinase (EC 2.7.11.-) PDK4 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LDRFYMNRISTRMLMNQHILIFSDS;SPEDQKALSDFT 2 10 0.9414 0.085978 0 0 0 4.8628 8.76378 0 0 0 0 0 0 0 0 0 0 A0A8C0YY29 A0A8C0YY29_CANLF Netrin receptor UNC5 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] GLSQESENCTDGLCILGIENAS;TYALTGEPITDCAVKQL;VYVDGSWEVWSEWSVCSPECEH 3 6.9 0.99261 -0.17643 0 8.28522 7.25276 0 0 0 0 0 10.6628 0 0 0 0 0 0 A0A8C0YY30 A0A8C0YY30_CANLF Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) RIOK1 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGSSECSD;DEEEDDDWDWDD;DEEEDDDWDWDDGV;DEMEEEEEEYDEEEDD;EEEEYDEEEDDD;EEYDEEEDDD;GDEMEEEEEEYDEEE;GDEMEEEEEEYDEEEDD;GGDEMEEEEEEYDEEEDDDWD;SVEHDHPHAL 10 8 1.0031 -1.9448 8.4068 0 5.24481 0 0 0 0 0 6.77768 0 8.26285 5.94134 0 0 5.94115 A0A8C0YY44 A0A8C0YY44_CANLF Syntaxin-binding protein 2 Canis lupus familiaris (Dog) (Canis familiaris) RVSVCVSMCLCVSVYVCPCAVS;VLCVHVCVCWV 2 20 0.99504 -0.15719 0 6.98413 0 0 0 10.5829 0 0 0 0 0 0 0 0 0 A0A8C0YY56 A0A8C0YY56_CANLF G protein-coupled receptor 143 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-tyrosine binding [GO:0072545] ATPGGQGA;TTWFIMVPMPAQLK 2 4 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 10.1279 0 0 0 0 0 A0A8C0YY58 A0A8C0YY58_CANLF Ras-like protein family member 11B (EC 3.6.5.2) Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] AADCCAGA;ARSGAGGG;IEGETLAI;RPQAPGTGTQAR 4 7.4 0.99894 -3.2627 9.80229 0 0 0 0 0 0 0 0 4.40081 0 0 0 9.0785 4.47275 A0A8C0YY66 A0A8C0YY66_CANLF CN hydrolase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" LSSLPSSSLPSLPS 1 2.5 0.77628 0.23073 0 0 0 0 0 0 0 0 12.0309 0 0 0 0 0 0 A0A8C0YY72 A0A8C0YY72_CANLF Peptidylglycine alpha-amidating monooxygenase PAM Canis lupus familiaris (Dog) (Canis familiaris) peptide metabolic process [GO:0006518] transport vesicle membrane [GO:0030658] "copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; lyase activity [GO:0016829]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]" DDGSESEEEYSAPLPAAS;DPNSKGGP;EGRTEATHIGGTSSDEMC;GVPIVLITTLLVIPVVVLLAI;GVPIVLITTLLVIPVVVLLAIA;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLGL;LLLLLLLLLLLL;LLLLLLLLLLLLGLARAL;LLLLLLLLLLLLGLARALGF;MGRPPRPLLLLLLLLLLLLGLA;PLLLLLLLLL;PLLLLLLLLLLLLGLARA;PLLLLLLLLLLLLGLARAL;PLLLLLLLLLLLLGLARALG;PLLLLLLLLLLLLGLARALGFRGPL;PPRPLLLLLLLLLLLLGL;PPRPLLLLLLLLLLLLGLA;PPRPLLLLLLLLLLLLGLARA;PRPLLLLLLLLLLLL;PRPLLLLLLLLLLLLGLARALG;PSSTGSYWFCDEGTCTDKANI;RPLLLLLLLLLL;RPLLLLLLLLLLLL;RPLLLLLLLLLLLLG;RPLLLLLLLLLLLLGL;RPLLLLLLLLLLLLGLARALG;RPPRPLLLLLLLLLLLLGL;RPPRPLLLLLLLLLLLLGLARALG;SSTGSYWFCDEGTCTDK;TKHFDMPHDIAASEDGTVYV;VLQVHYGDISAFRDN;VPIVLITTLLVIPVVVLLAI;VPIVLITTLLVIPVVVLLAIALYI 37 15.8 1.0045 -0.81937 9.72499 11.0947 9.52178 5.69502 4.01632 8.9857 10.1085 9.42442 10.7585 4.68762 7.93463 7.37016 10.462 7.87215 8.43692 A0A8C0YY88 A0A8C0YY88_CANLF Ribosomal protein L10e/L16 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] CKNKPYPKSCFC 1 6.7 0.95329 0.05044 0 0 0 7.00562 8.73559 0 0 0 0 0 7.74658 7.29361 0 0 0 A0A8C0YYA1 A0A8C0YYA1_CANLF Shroom family member 2 SHROOM2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule [GO:0005874] actin filament binding [GO:0051015] EHPTAHPMGQKARCYLPQHEEAL;GTLPRDYRYPEETL;HLGEEQLKCLFDSLQP;IVFDILASYLSEESL;LDCGVLPS;LDCGVLPSDH;QEPEEDSGSDLDHD;QRRKLLPKIPSPRT;RWKFFEETSRPIHQRPGQRQALCG;SAAKSNSS;SLSHIPCASVEKLSS;SSGCAPDA 12 10.2 1.002 -2.624 0 0 6.84449 5.88242 9.30779 0 8.0974 9.92512 8.19746 11.7157 0 0 11.1518 0 9.49947 A0A8C0YYB2 A0A8C0YYB2_CANLF Serpin domain-containing protein SERPING1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GVEAAAGA;SLPSDTRLVLLNAVYLS 2 4.7 0.98706 -0.22988 0 8.65546 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YYC4 A0A8C0YYC4_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) DUSP26 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine/serine/threonine phosphatase activity [GO:0008138] LEEMPAVQ;SCRFHPPGAEPARREDPGA 2 11.1 0.98562 -0.44911 0 0 0 0 0 0 0 0 0 0 9.05962 0 0 0 0 A0A8C0YYC5 A0A8C0YYC5_CANLF Dymeclin DYM Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794] CFSLCLCLCLSLSPLSVF;SSPTSGSLHEACFSLCLCL;VIRTIQYNMTRTRDKYL;YAQDLNVIEE 4 8.2 0.98763 -0.46739 9.10913 0 0 8.82037 0 0 0 0 8.69585 0 0 0 0 0 0 A0A8C0YYD3 A0A8C0YYD3_CANLF LIM zinc-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ENLIFMNTRTDKDGKGSQDLETI;KKKRQSWFPP;PTGNGMKSTSQGTTLR;QENISGKYIQ;TFLQDNSWIKKRPEEEKDENY;YSKVMAKWIQ 6 13.1 0.97519 0.046454 0 0 0 0 0 0 0 0 9.50625 0 0 0 0 0 0 A0A8C0YYE5 A0A8C0YYE5_CANLF Neuromedin-S Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EAGRARPSPGGEP 1 3.9 0.98272 -0.25004 0 11.4986 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YYF0 A0A8C0YYF0_CANLF Low density lipoprotein receptor class A domain containing 3 Canis lupus familiaris (Dog) (Canis familiaris) receptor-mediated endocytosis [GO:0006898] plasma membrane [GO:0005886] FILGADGV;FQCNGFEDCPDGSDEENC;KCGPTFFPCASGIHC;NNCQDNSDEESCES;VVALLALVLHHQRKRNNLMTL 5 19.8 1.0019 -1.2601 0 0 0 0 0 0 9.26207 0 0 0 0 8.6037 0 0 5.33967 A0A8C0YYF5 A0A8C0YYF5_CANLF DBF4-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell cycle phase transition [GO:1901987] Dbf4-dependent protein kinase complex [GO:0031431] nucleic acid binding [GO:0003676]; protein serine/threonine kinase activator activity [GO:0043539]; zinc ion binding [GO:0008270] SSGGGGGS;SSSGGGGG;VIEGFLSKEVSY 3 3.2 0.95298 0.05044 0 0 0 0 5.78377 0 0 0 0 0 0 0 0 0 0 A0A8C0YYF6 A0A8C0YYF6_CANLF Mitochondrial inner membrane protease subunit 2 IMMP2L Canis lupus familiaris (Dog) (Canis familiaris) protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465] mitochondrial inner membrane peptidase complex [GO:0042720] serine-type endopeptidase activity [GO:0004252] GEDTHPSERGHTVSRQL 1 6.6 0.98416 0.046227 0 0 0 0 8.67292 0 0 0 0 0 0 0 0 0 0 A0A8C0YYH4 A0A8C0YYH4_CANLF Dedicator of cytokinesis 3 DOCK3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] CTVNLMNFYKSEINKE;DIHELYVYK;EASYYDNIMEQ;ELFSMWQNL;GKQISERF;IVKTSSLEADVMEE;LDDNTEKYGLLVF;MPVPHHFFLSL;PEKIERMCALFTDLSSKDMKRDLY;QEQVHVLGVGLAVHEKFVHPEM;SPLMRDDGTTLSDD;TVDSRLFSFSES;VMRLLTSNII;YPNPRYQGSVT 14 9 0.99769 -3.3664 9.42282 0 11.3315 2.71857 9.27801 0 0 0 6.20471 9.34975 10.3048 11.7979 6.03956 8.05821 8.86118 A0A8C0YYJ2 A0A8C0YYJ2_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) GRGGGAHE;VGGSCWGG 2 3.6 1.0034 -1.6148 0 0 0 0 0 0 0 0 6.59328 0 0 0 0 0 0 A0A8C0YYL1 A0A8C0YYL1_CANLF Genetic suppressor element-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEFLQQRRRL;EADREREKER;EEFAHQFHES;EERRRREAQ;EKGYYYDLDDSYDESD;LTQEMDQDSEDDEE;TQEMDQDSEDDEEDGE;VDTSIHYNIP;YIYDEFLQQRR;YYDLDDSYDESDE 10 7.6 1.0034 -2.2572 10.7963 9.50122 9.91489 0 0 0 9.47581 10.308 10.239 10.4455 0 10.0788 0 10.0761 0 A0A8C0YYM1 A0A8C0YYM1_CANLF Myosin VIIA MYO7A Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; auditory receptor cell stereocilium organization [GO:0060088]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; intracellular protein transport [GO:0006886]; phagolysosome assembly [GO:0001845]; pigment granule transport [GO:0051904]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; myosin complex [GO:0016459]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium base [GO:0120044]; synapse [GO:0045202] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146]; protein domain specific binding [GO:0019904]; spectrin binding [GO:0030507] AAISGQHSWIE;EVRAKPYTLEEFSYDYFRPPPKH;IPKLLRELVPQDLIR;LEGLRKRSKYVV;LSLGCSDLGCAAPHSG;MVILQQGDYV;NKPMNIISLIDEE;PGKDPMADS;SIFHYYQEL;TTVPGKDPMADSI;WRLFFRKEVFTPWHNP 11 6.1 0.95011 0.053874 4.78795 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YYM2 A0A8C0YYM2_CANLF Transmembrane protein 144 TMEM144 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate transmembrane transporter activity [GO:0015144] AGPGFIAAMWGVFMFKEIKVCF;VGCSLAVISGILYG;YIKDHSKRNDSIYAG 3 14.6 0.99531 -0.15323 0 9.25977 0 0 0 10.4213 0 0 0 0 0 0 0 0 0 A0A8C0YYM3 A0A8C0YYM3_CANLF NADH:ubiquinone reductase (H(+)-translocating) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LKGTWKAKGFTTF;YSNGLSMLEGLP 2 5.9 0.99171 -0.1826 6.8627 0 0 0 0 0 0 0 0 0 10.9528 0 0 0 0 A0A8C0YYM5 A0A8C0YYM5_CANLF SH3 domain-containing protein DSP Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoskeleton [GO:0005856]; desmosome [GO:0030057]; plasma membrane [GO:0005886] AVEDRFDQQ;GVKGKKKM;IEAYMDTLQTQ;IEQYYEAI;LANFRGSEKYCY;LEELVQIAHIVDY;LQKVRRQM;LSVQKRSMSF;SPIAAIFD 9 4.2 0.9926 -0.16823 0 0 0 0 0 0 10.3457 0 0 0 0 0 0 0 0 A0A8C0YYN2 A0A8C0YYN2_CANLF Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (p21-activated kinase 3) PAK3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] EEDEEEEEEEDDNEPPPVI;EEEDEEEEEEEDDNEPPPVIAPRPE;FLNRCLEMDV;NEILVMRENKNPN;SAHGYIAAHPSST;VGDELWVVMEY 6 13.2 0.98765 -0.37342 0 9.15583 0 4.14617 0 0 0 0 0 0 0 9.82238 0 0 0 A0A8C0YYP1 A0A8C0YYP1_CANLF U2A'/phosphoprotein 32 family A C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GSGRPEMSYAL;QTVVSRLQALQKQEQQEDV;TLSVNSVSSLEPVSQCQQ 3 16 0.99458 -0.19093 0 0 0 0 0 5.13578 0 0 0 0 0 0 4.06393 10.1214 0 A0A8C0YYQ6 A0A8C0YYQ6_CANLF Succinate dehydrogenase assembly factor 3 (SDH assembly factor 3) (SDHAF3) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex II assembly [GO:0034553] mitochondrial matrix [GO:0005759] HLAAAPGS 1 5.7 1.0032 -1.1044 0 0 0 0 0 0 0 0 0 0 4.62428 0 0 0 0 A0A8C0YYQ7 A0A8C0YYQ7_CANLF Centrosomal protein of 290kDa coiled-coil region domain-containing protein CEP290 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EAENENSKLRRENE;EDLKYNYKEEVKKNI;FEEIEDLKYNY;GERKFDFTSL;IAKRQVEILKAQQQSREKE;IVHQTDNVMDQLKKEND;LIEELQKKIKKL;LTEFRNSKS;MDPFVSLT;MYEHVRTSLKQVEERNF;NKQSLIEELQKKIKK;SLSDNLND;VQELTDLLKAKNEEDDPVMAAVNAK 13 6.1 1.0021 -1.2673 2.89472 8.25607 0 0 0 0 10.4577 8.35204 0 9.20601 0 0 8.79675 6.00522 10.2906 A0A8C0YYR3 A0A8C0YYR3_CANLF CUGBP Elav-like family member 3 CELF3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] AIAATPVSAIPAAL;TSTPPAIA 2 4.1 1.0027 -1.3489 0 0 0 0 0 0 11.99 14.4024 14.4053 0 0 12.3747 0 0 0 A0A8C0YYR7 A0A8C0YYR7_CANLF Ig-like domain-containing protein LY9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EASRVIKTKHITLLVYGRLKKPK;LVTPERMVPASVAQNSTVY;TPERMVPASVAQN 3 7.2 0.9898 -0.21211 0 0 0 5.092 0 11.3131 0 0 0 0 0 0 0 0 0 A0A8C0YYS5 A0A8C0YYS5_CANLF Mediator of RNA polymerase II transcription subunit 25 MED25 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592]; transcription regulator complex [GO:0005667] APGVGPPFSQAPAPPLPPGPPG;LQLRPPQPQPQ;VESTTYSGYTTESLV;VGGGSAPGPLQ 4 7.9 1.0026 -0.89983 0 0 0 10.0794 9.93521 0 0 0 0 0 0 0 0 0 10.2286 A0A8C0YYU8 A0A8C0YYU8_CANLF PX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020] dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091] PAQGGRAGRGGAGRGGAGR 1 5.8 0.95064 0.049797 0 8.09714 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YYV6 A0A8C0YYV6_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RAHPPKSS;VGAWGLLRLL 2 8.1 1.0033 -0.87577 0 9.40297 0 0 0 0 0 0 0 0 0 0 0 0 5.62047 A0A8C0YYV9 A0A8C0YYV9_CANLF "5'-nucleotidase, cytosolic IA" Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] AATIFSPSRDVAV;FYSKGLRLECPIRTYL 2 8 0.99355 -0.16112 0 0 0 0 0 0 6.58954 11.3478 0 0 0 0 0 0 0 A0A8C0YYW7 A0A8C0YYW7_CANLF KN motif and ankyrin repeat domains 4 KANK4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] PDATIGQY;TLLQNKASEDSSLNSGSPMPPALPL 2 3.3 1.0037 -1.0689 0 0 0 0 0 0 8.21408 0 0 0 0 0 7.87811 0 0 A0A8C0YYW9 A0A8C0YYW9_CANLF Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1 protein) FIP1L1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] ETEDDSDSDSDDDEDDVH;LEVIPVTSTTNK;LYGGPWDVHVH;RDRDRDRERDRDRDRERERTRERER;SDSDSDDDED;SDSDSDDDEDDVHVT;SDSDSDDDEDDVHVTIGD;VIGQTITISRVEG;YYSRREKDRDRDRDRDRERDRDR 9 16.6 1.0029 -1.6601 0 10.8021 15.7442 0 5.10165 0 16.2552 0 11.7873 5.81673 0 0 15.9865 7.31325 0 A0A8C0YYX3 A0A8C0YYX3_CANLF Neurogenic mastermind-like N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607] transcription coactivator activity [GO:0003713] ESSDRERESTLQ;VQLLQGCQVQLEPV 2 7.6 0.99438 -0.12496 11.2147 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YYX8 A0A8C0YYX8_CANLF Repulsive guidance molecule BMP co-receptor b Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] DTSKEPKKKKKKSVI;LFPGGGGP 2 2.8 0.95033 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 3.47768 0 A0A8C0YYY1 A0A8C0YYY1_CANLF TSPY like 2 TSPYL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] CDSESPDHNET;DDEDNDGNEGDNEGSDDD;DDNEENTDDNDENPDGDDE;DDYHVMEDI;DNEENTDDNDENPDGDDE;DNEGSDDDGNEGDNEGSDDDDRD;DNTDDNEENTDDNDENPDGD;EDNDGNEGDNEGSDDDGNEGDNE;EGSDDDGNEGDNEGSDDDDRDIED;ESVRKRRRRRRKRKQRKVK;ESVRKRRRRRRKRKQRKVKKERN;GSEEDSEQEGEESDNEEGSDEE;LETCSAEEWEYQG;LSSSEPTQLDQLP;LVEDDDED;NEGSDDDDRDIED;NEGSDDDGNEGDNEG;NKQDDYEDEVENISEESSVEEEEE;NPEDNTDDNEENTDDNDENPD;RRKRKQRKVK;RRRRRKRKQRKVKKERNAEKIECIL;RRRRRRKRKQRKVKKERN;TDDPDKDQDNSN;TLGAGGPG;VRKRRRRRRKRKQ 25 29.3 1.0032 -1.6255 4.57996 5.56566 8.95024 3.79452 0 6.61822 5.42385 8.66135 9.02012 7.96498 7.02181 9.99506 7.23888 0 10.4651 A0A8C0YYY8 A0A8C0YYY8_CANLF ADAM metallopeptidase domain 20 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DMGFDCDVSTCNF;IVVTGINQEKCFGYDAHHGTEIPE;SLGSDCSEGSCCVNC;VRGGGKPVRCEEDDVL 4 9.2 0.99176 -0.18485 0 0 0 0 8.67373 0 0 0 0 0 3.01464 0 0 9.92942 0 A0A8C0YYZ5 A0A8C0YYZ5_CANLF Protein phosphatase 1 regulatory subunit 18 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] actin binding [GO:0003779]; phosphatase binding [GO:0019902] AQPDDDDDDDDDDD;DDDDDDDDEELLL;DPEAPRAPSPPAAQPDDDDDDDD;EAWDWRQSPGE;EEERKDCLE;EWSLRLAEPAEQSPRRKEV;PAAQPDDDDDDDDDDDEEL;PDDDDDDDDDDDE;QPDDDDDDDDDD;SPGEPSPA;SSRLSEARKW 11 14.2 0.99777 -0.097814 0 0 5.84175 0 0 6.31141 0 3.41441 0 0 0 0 0 0 0 A0A8C0YYZ9 A0A8C0YYZ9_CANLF AMP deaminase (EC 3.5.4.6) Canis lupus familiaris (Dog) (Canis familiaris) IMP salvage [GO:0032264] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] EEYSIATQVWKLSSCDMCE;IFLPLFEATVHPA;RNAAGAGP 3 4.2 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4939 A0A8C0YZ15 A0A8C0YZ15_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] AATTTTGLSVLEGN;GAVLIIVILGLILYLRWKRSKGLQ;SLPLSVGAAVGAGAVLIIVILGLI;VLIIVILGLILYLRWKRSKGLQ 4 16.7 0.9387 0.060882 0 8.33869 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YZ16 A0A8C0YZ16_CANLF Cytochrome P450 family 4 subfamily B member 1 CYP4B1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ATGLILVLGFLKLIRLLLR;ATGLILVLGFLKLIRLLLRR;ATGLILVLGFLKLIRLLLRRQMLAR;EILGDRDSFQW;GFLKLIRLLL;HPFAFMPFSA;LVLGFLKLIRLLL;LVLGFLKLIRLLLRRQML;VLGFLKLIRLLLRRQ;VLWATGLILVLG;WLTPHGRRFLRACQAAHDHTDQVI 11 14.3 1.0018 -1.2129 0 0 0 6.27964 13.5106 0 0 6.17253 8.4002 0 0 8.91136 0 8.44878 0 A0A8C0YZ18 A0A8C0YZ18_CANLF Extended synaptotagmin 2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] lipid binding [GO:0008289] EAQDLQGKDTYLKG;LLDEWFALDEV;STLKMKIA 3 4.1 1.0036 -1.652 0 0 0 0 0 5.75857 0 0 0 0 0 0 0 0 0 A0A8C0YZ20 A0A8C0YZ20_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YASSSCLLVHCFDDTHSNCLSHVT 1 13.3 0.97366 0.041303 0 7.60021 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YZ22 A0A8C0YZ22_CANLF Ig-like domain-containing protein NRG1 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] extracellular region [GO:0005576]; plasma membrane [GO:0005886] signaling receptor binding [GO:0005102] VGLRARRTDATSRADSGGP;VGQLKKSRRGVPQNLSELR 2 6.7 0.93519 0.098873 0 0 0 0 0 0 0 0 0 7.41633 0 0 0 6.61606 0 A0A8C0YZ57 A0A8C0YZ57_CANLF Olfactory receptor OR5G1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;LDVNKVVSVFYTAV;VGPYTVGFLSTMTHTT 3 13.7 0.98911 -0.19685 0 0 0 5.88489 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YZ70 A0A8C0YZ70_CANLF Transient receptor ion channel domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; plasma membrane [GO:0005886] "inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" APGAWNLLLPLP;EVVHMLLMKGA;PAPEEEEEEEEEEGEDGGS;PVLTALEL;VLTALELSN 5 5.6 0.86172 0.18502 0 0 0 0 0 0 11.3577 8.43892 0 0 0 0 0 0 0 A0A8C0YZ74 A0A8C0YZ74_CANLF Collagen type XXVIII alpha 1 chain Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] GSEGPIGPQGLQGLS;LELMFVIDSSESVGLENFEI;PVLNLQPEK 3 4 0.98874 -0.2605 0 0 0 0 0 0 0 0 0 9.59576 0 7.83908 0 0 9.13358 A0A8C0YZ79 A0A8C0YZ79_CANLF Rho guanine nucleotide exchange factor 18 ARHGEF18 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DEQEDGIPQ;EERNTWMAHIR;EQERQRNFEKQREE;PSNTLGASEEAPPAGP;QSTRGNMLLEQERQRNF;RITKYPVLVE;SSRGSFCRISSG;TVSQKGGP;TVSQKGGPQ;VIAQQDSYVEMQRAS;VTQRITKYPVLVERI 11 7.2 1.0016 -2.6324 8.02967 5.77634 9.69862 0 0 5.61994 8.44282 9.45953 7.18824 8.14328 0 0 5.48401 10.0779 6.93275 A0A8C0YZ82 A0A8C0YZ82_CANLF Multifunctional fusion protein [Includes: Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-); Pyruvate kinase (EC 2.7.1.40)] PKM Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] DENILWLDYKNICK;LGLQLKKIL;LGMFTSQQWKHLSNDFLKTQ;LLVAMCRAALE;QVKQKGADFLVTEVENGGSL;SGMGKGQHRMPSKD;SIEVFQPSNKEGFGLG;VLTGWRPGSGFTNT 8 10.2 1.002 -0.6778 8.75959 7.31424 11.7035 0 0 0 10.6644 10.4583 0 0 0 0 0 0 11.2485 A0A8C0YZ95 A0A8C0YZ95_CANLF Testis expressed 38 TEX38 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PLDTCPERNI 1 4.8 0.9932 -0.17609 0 0 0 0 0 12.6741 0 0 0 0 0 0 0 0 0 A0A8C0YZA0 A0A8C0YZA0_CANLF Transmembrane protein 185A TMEM185A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLFQDFNPSKFL;LLLLLFEVLVCD;MFLLQQPSLQEGLPP;VSPVSVAACVWGFR 4 15.1 0.99488 -0.15637 0 0 0 0 0 0 0 11.5222 0 0 0 10.2303 0 0 0 A0A8C0YZD1 A0A8C0YZD1_CANLF Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) PRORP Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] mitochondrion [GO:0005739] nuclease activity [GO:0004518] GHQLAILNRLPGSKIIFQ;NVAKTFPKA;PGHSFLSLFLENCYGIRNQ 3 8.3 1.001 -0.70603 0 0 0 0 0 0 0 11.6911 0 0 9.42918 0 0 0 7.05745 A0A8C0YZD7 A0A8C0YZD7_CANLF Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4) Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151] ubiquitin-ubiquitin ligase activity [GO:0034450] AGWSASHLCGL;AKLVEVMFMTNPAVQPR;ALAAKECSL;ALSGDSSDEDEEDDDDDDDGDDE;DDDDDDDGDDEGGGGGDEFSCVQ;DDDDDDGDDEGGGGGDEF;DEDEEDDDDDDDGDDEGG;DEDEEDDDDDDDGDDEGGG;DEDEEDDDDDDDGDDEGGGG;DEEDDDDDDDGDD;DSSDEDEEDDDD;DSSDEDEEDDDDDDDGDDEGG;EDDDDDDD;EDDDDDDDGDDEG;EDDDDDDDGDDEGGGG;EDDDDDDDGDDEGGGGGDE;EDDDDDDDGDDEGGGGGDEFSC;EDEEDDDDDD;EDEEDDDDDDDG;EDEEDDDDDDDGDDEG;EDVAEFLFF;EEDDDDDDDGDDE;ENDRREKRSLSDKEPSSG;ENPEKYGFEPKKLLDQLTDI;GDDEGGGGGDEFSCVQFGSSLG;GDSSDEDEEDDDDDD;GDSSDEDEEDDDDDDDGD;KLLVPSLMKF;LSGDSSDEDEEDDDDDD;PLGIREGDT;PSAVSRRPSS;SGDSSDEDEEDDDDD;SGDSSDEDEEDDDDDDDGD;SGDSSDEDEEDDDDDDDGDDEG;SGDSSDEDEEDDDDDDDGDDEGG;SILPSCRRYI;SMDIDGVSCEKSMSQVDVDSG;SSDEDEEDDDD;SSDEDEEDDDDDD;SSDEDEEDDDDDDD;SSDEDEEDDDDDDDGDDEGGG 41 14.2 1.002 -2.6124 9.89978 10.5797 5.36922 4.26221 4.2874 9.31277 8.88423 10.3496 10.503 8.61618 10.1179 5.85449 12.3049 4.83218 7.9607 A0A8C0YZD8 A0A8C0YZD8_CANLF SPIN-DOC-like zinc-finger domain-containing protein SPINDOC Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634]; site of DNA damage [GO:0090734] PAVSLLQDWSKHPQGTKSV;PEPMLRVA;SSTTMGGQPEAGS;TSDSGQDVEADPDS 4 14.1 1.0021 -1.2459 11.4129 0 3.94598 8.90761 8.69024 0 0 0 0 0 0 0 0 0 0 A0A8C0YZG0 A0A8C0YZG0_CANLF Lysosome-associated membrane glycoprotein 2-like luminal domain-containing protein LAMP2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] EKDKTSTT;NKVASVININPNT 2 5.5 0.98546 -0.4494 0 0 0 0 0 0 0 0 7.18021 0 0 0 0 0 0 A0A8C0YZG7 A0A8C0YZG7_CANLF Double PHD fingers 1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] histone binding [GO:0042393]; histone H3K4 methyltransferase activity [GO:0042800]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713] DFCLGGSKKTGCPED;GLPEGPVLEALLCAETGE;GVGRSKGG;LSYHYTHTHLAEEEG;PPMAEPPEGERRGGHH;RKHTAKKAPD;SLCGTSENDDQLLFCDDCDRGY 7 23.4 1.0034 -1.5211 4.4661 0 0 0 0 8.04647 0 0 10.4306 0 0 9.14738 11.1964 0 4.7385 A0A8C0YZH0 A0A8C0YZH0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) GEEGTLLHCWWECELVQP;MDAFLESHKL;SEVSQSVKDKHY 3 4.5 0.9723 0.048313 0 0 0 0 0 0 0 0 8.21242 0 0 0 0 0 0 A0A8C0YZH6 A0A8C0YZH6_CANLF Gla domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509] AMVPVVTT;EVFDSSGLSPGFLEYV;LVIFLIWRCF;RKAGSWAGGSRTLCWIQ 4 16.8 1.0038 -1.6773 0 11.206 3.52356 0 8.30232 0 11.3944 11.4041 11.2862 0 3.81977 0 4.03536 0 0 A0A8C0YZI3 A0A8C0YZI3_CANLF Vascular endothelial growth factor receptor 2 KDR Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ATP binding [GO:0005524]; growth factor binding [GO:0019838]; vascular endothelial growth factor receptor activity [GO:0005021] DKTATCKTVAVKMLKEGATHSE;LGNLLQANAQQDGKDYIV;PTEQESVSLWCT;PVDSYQYGTTQSLT;VGEVPTPVCKNLDALWRMNA 5 6.5 0.98695 -0.35859 0 0 0 0 0 10.3252 0 0 0 0 0 10.1981 11.0137 0 11.1159 A0A8C0YZK7 A0A8C0YZK7_CANLF Olfactory receptor family 52 subfamily A member 1 OR52A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VAGFDLTFITMSYIQ 1 4.9 0.9514 0.053887 0 0 8.58545 0 0 0 0 0 0 0 0 0 0 8.40331 0 A0A8C0YZN1 A0A8C0YZN1_CANLF Cohesin subunit SA (SCC3 homolog) (Stromal antigen) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; nucleus [GO:0005634]" EHQEEIEGMMNAL;HLRRNVKKRAAKRPL;ILLLSLKQVLMLQ;LVDSLWDCAGSQLKDWESLTSLL;TQGQPLSGNQR 5 6.8 0.94433 0.059561 0 0 0 0 0 0 0 0 0 4.6688 0 0 0 0 0 A0A8C0YZN6 A0A8C0YZN6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;EAGGGCGG;EASPCCQQSSCQPSC;PCCQQSSCQPSCCNSSPCQEGCC;PSCCNSSPCQEGCCVSVCC;PSSCQPSC;QPSCCNSSPCQEGCC;QPSPCRPS;SCGSCSPCQEGCCM;SPCQEGCCMSVCC 12 33.9 1.0041 -1.1044 0 0 7.804 5.64605 0 0 0 0 0 6.15719 0 0 0 6.42846 0 A0A8C0YZP0 A0A8C0YZP0_CANLF Myotrophin Canis lupus familiaris (Dog) (Canis familiaris) DGLTAFEATDNQAI 1 26.9 0.93205 0.060787 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9423 0 A0A8C0YZP1 A0A8C0YZP1_CANLF ALMS motif domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] microtubule binding [GO:0008017] ADQITGLSTVTPGTYSYSE;APHFNNKMSHSFLHCLLESRG;DTECCNLD;EDDRRKVEEIKAKLFSHE;EEPEEPANLGSE;EKHCIFYPQTL;GPGICWFAPIT;GVSWFVPVEN;HNIFYQQAL;HRPLAGPDRERLR;ISRSGERIKRLKLIVQ;KEAEEPEEPANLGSEKVVMVEEVE;LEEEEEEEEEEKEAEEPE;LQDLRRFEEVAD;LVIQDNFASPDLPLL;PLEEMDCH;QPSELEFVPLRGIPGKS;SDILTQTDREVTLQER;SHREKSNNFYPQELPDK;SKLQKKKRYKSLEKFHK;SQGFELKENRSA;STVPVPTDQRTE;TYTLDDDTECCNLDENAVV;VISKGHVSFPH;VLHNSYSQ;YSLGEKHSI 26 6.2 0.997 -4.0873 10.0963 8.73481 9.64668 9.537 11.7871 10.1838 8.90436 12.8881 9.25127 3.78073 0 0 8.14088 3.02731 8.28711 A0A8C0YZP3 A0A8C0YZP3_CANLF Testis specific serine kinase substrate Canis lupus familiaris (Dog) (Canis familiaris) EALRAKNLLLTDKMKPEE;GVTTPAKGITKKKKAV 2 6.1 0.93592 0.097546 0 0 0 0 0 7.19997 0 5.89671 0 0 0 0 0 0 0 A0A8C0YZP7 A0A8C0YZP7_CANLF BIG2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYDQQGRRFDNF;GVLDWPDDGFPRWRR;LVSYTHGHIH;QLQNSITGPEG;RLPHGPVV;SSHRNPLLDL;TVTDKAGQRINSAP;YTDQAEILLSNHYT 8 4.8 1.0019 -1.4372 0 10.7919 10.0604 0 5.422 6.29355 0 13.2059 0 0 0 0 0 0 0 A0A8C0YZQ2 A0A8C0YZQ2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TAOK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LETTPKAQ;SDNEEEEEEEEEEEEEEEGPEA;YFELQCRQYK 3 4.1 1.0043 -1.1044 0 0 0 9.2076 0 0 0 0 0 0 0 0 0 10.2391 0 A0A8C0YZQ8 A0A8C0YZQ8_CANLF Protein IMPACT HRH4 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; regulation of translation [GO:0006417] cytoplasm [GO:0005737] actin binding [GO:0003779] LPNEYPGTAPPIY 1 4.2 0.93929 0.059745 0 0 0 0 0 0 0 0 0 0 0 0 9.36962 0 0 A0A8C0YZT6 A0A8C0YZT6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGIFFFLLFNMKTSSY 1 15.7 0.98149 -0.24889 0 0 0 0 0 0 0 0 11.3045 0 0 0 0 0 0 A0A8C0YZV0 A0A8C0YZV0_CANLF TLDc domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AVFVFNINSVEHLSYEMMA;GPTGSGKS;LTNMDNCSTLPQDNFLNM;NPNRPITPNHPTFI;PYILKGCVPDRYQ;YRDLVRQI 6 8.2 1.004 -1.9899 9.57507 11.562 0 0 0 8.68794 10.3922 10.5482 10.9445 0 0 0 4.73509 0 0 A0A8C0YZV6 A0A8C0YZV6_CANLF Peptidase S8/S53 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] Golgi apparatus [GO:0005794]; membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] GPAPPGVAPPRQVGHAPPAPPR;SNLWKHQKLLSIDLDKVVLP;STVKLPIKVKII;WNGDHIHTNFRDMYQH;YTSYGVTPPSL 5 6.8 0.99286 -0.28355 0 0 0 0 0 0 10.1096 0 0 0 8.83077 0 4.49723 8.14216 0 A0A8C0YZW5 A0A8C0YZW5_CANLF Piwi like RNA-mediated gene silencing 4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] RNA binding [GO:0003723] DATFAPKTGGSQ;ETSKGETVKMTI;SPICIQVLNIIFKKIFKKLA;VAEDFLHCLRRAGSSMG;YYDSIKKY 5 6.9 0.98822 -0.26462 0 0 0 0 8.91307 0 0 0 0 0 0 0 0 0 0 A0A8C0YZY9 A0A8C0YZY9_CANLF NXPE family member 3-like Canis lupus familiaris (Dog) (Canis familiaris) ASTSPQTSTYHLRKTSQ;EPRTLVVI;KTHGGDLFRAQ;LSPQQPCHPGIMGP;SLCPLFTI;VLRGIWRDQWAMVDFMGYFRGPTGY 6 15.5 1.0045 -1.1044 0 0 0 8.25932 0 0 0 0 0 0 0 0 0 0 0 A0A8C0YZZ3 A0A8C0YZZ3_CANLF Endoglin ENG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVLSAKKNVLLQLQAPGI;PVVAVAAP 2 4.3 1.0035 -1.0561 3.38626 4.10341 9.88669 7.19042 7.63771 0 0 0 0 0 10.2186 0 10.3911 0 0 A0A8C0YZZ4 A0A8C0YZZ4_CANLF CTCK domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) animal organ development [GO:0048513]; negative regulation of activin receptor signaling pathway [GO:0032926]; regionalization [GO:0003002] extracellular region [GO:0005576] EKMLSRFG;LLLLLVLLPLGKAA;LVLLLLLVLLPLGKA;VLLLLLVLLPL 4 9.1 1.0021 -0.67853 0 0 4.09576 0 0 0 0 0 0 0 0 0 6.60857 0 3.79929 A0A8C0YZZ7 A0A8C0YZZ7_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF19A Canis lupus familiaris (Dog) (Canis familiaris) "protein ubiquitination [GO:0016567]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]" glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; postsynapse [GO:0098794] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EVQVDIESKPSK;LSDSMPSVADSHSSHFSEFS;MNDGSCNHMTCAVCGCEFCWL;SVAEARHNPS;VLMEKYEEFMLR 5 8.9 0.99062 -0.26776 10.374 0 4.36709 0 9.87334 0 0 0 0 6.17363 0 0 0 0 0 A0A8C0Z000 A0A8C0Z000_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;ETCCEPPCCAPASCL;PCCQQSSCQPSCCNSSPCQEGCC;QEGCCASPCCQQSSCQPSC;QPSCCNSSPCQEGCC;SCGSCSPCQEGCCM;SPCQEGCCASPCCQQSSCQP;SPCQEGCCMSVCC 10 32.4 0.93433 0.097616 0 0 4.20484 0 0 0 6.00389 0 0 0 0 0 0 0 0 A0A8C0Z009 A0A8C0Z009_CANLF ALMS motif domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] microtubule binding [GO:0008017] ADQITGLSTVTPGTYSYSE;APHFNNKMSHSFLHCLLESRG;DTECCNLD;EDDRRKVEEIKAKLFSHE;EKHCIFYPQTL;GPGICWFAPIT;GVSWFVPVEN;HNIFYQQAL;HRPLAGPDRERLR;ISRSGERIKRLKLIVQ;KKRTLKVRIQK;LFKKRTLKVRIQKTSLY;LQDLRRFEEVAD;PLEEMDCH;SDILTQTDREVTLQER;SHREKSNNFYPQELPDK;SKLQKKKRYKSLEKFHK;SQGFELKENRSA;STVPVPTDQRTE;TYTLDDDTECCNLDENAVV;VISKGHVSFPH;VLHNSYSQ;YSLGEKHSI 23 5.5 0.98509 -0.24134 0 0 0 0 0 0 0 3.7781 0 0 0 0 0 0 0 A0A8C0Z014 A0A8C0Z014_CANLF Ankyrin repeat and SOCS box containing 16 ASB16 Canis lupus familiaris (Dog) (Canis familiaris) AEQGFWVL;DTWVEAVLPELWQ;GVPNAAGH 3 7.1 1.0034 -1.5434 0 0 0 0 0 0 11.8477 0 0 0 0 0 0 0 0 A0A8C0Z019 A0A8C0Z019_CANLF Arachidonate 5-lipoxygenase-activating protein (MK-886-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) leukotriene biosynthetic process [GO:0019370] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] enzyme activator activity [GO:0008047]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; leukotriene-C4 synthase activity [GO:0004464] TARTCGPEL 1 4.1 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.77913 A0A8C0Z027 A0A8C0Z027_CANLF B-cell CLL/lymphoma 7 protein family member A BCL7A Canis lupus familiaris (Dog) (Canis familiaris) SWI/SNF complex [GO:0016514] SLRIYKWVPVTEPK;SSPGMMDMHDDNSNQSSIADA 2 16.7 0.99106 -0.18557 0 0 0 0 0 5.55139 0 0 0 0 0 0 12.5397 0 0 A0A8C0Z032 A0A8C0Z032_CANLF Contactin 2 CNTN2 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; brain development [GO:0007420] axon [GO:0030424]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632] EFRVVASNILGTGE;IGHALVQIRTTG;SKAQDAGV;TRRKAHLLLLVAVVLVSSPA 4 5.2 1.0036 -1.5984 0 0 0 9.49773 0 0 14.438 0 9.54697 0 11.1009 0 9.17508 0 11.0976 A0A8C0Z035 A0A8C0Z035_CANLF Coiled-coil glutamate rich protein 1 Canis lupus familiaris (Dog) (Canis familiaris) CECDNEECDGKEEESQ;CECECDNEECDG;CECECDNEECDGKE;CECECDNEECDGKEEE;DCVEEGEEEQEEEEGE;ECECECDNEECDGK;ECECECDNEECDGKEEESQEEEE;ECECECDNEECDGKEEESQEEEEE;EECECECD;EECECECDNEEC;EECECECDNEECD;EECECECDNEECDGKE;EECECECDNEECDGKEEESQ;EEEEDREEEEEEED;EEGEECECECDNEECDGKEEE;EEGRRTRRRRRRIRRRRRRQKRRP;EELERQQEALR;EEQGEEGEECECECDN;EEQGEEGEECECECDNEECD;EEQGEEGEECECECDNEECDGKEEE;EGEECECE;EGEECECECDNEEC;EGEECECECDNEECDGKEEESQ;EGEGEEEDREEEEDREEEEEEED;EQEEEEGEEGRRTRRRRRRI;GEEGEECECECD;GEEGEECECECDNEE;PLGQEEQGEEGEECECECD;QEEQGEEGEECECECD;QGEEGEECECECDNEECD;RRGAPIYKRRRRYGPKS;RTRRRRRRIRRRRRRQ 32 31.9 1.002 -1.4301 10.4649 7.24241 3.99041 0 7.56902 7.74651 6.60769 6.53588 9.17822 10.1779 7.26576 7.20242 5.34184 6.6837 7.59291 A0A8C0Z039 A0A8C0Z039_CANLF Clusterin associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995] DLLNNVASDEAN;SVLYNAMK;TSSSKKQVGFLFH;VGTMQGGDSDDDME 4 10.4 0.91176 0.12053 0 0 0 0 0 8.69763 9.32652 0 0 0 0 0 9.68027 0 0 A0A8C0Z074 A0A8C0Z074_CANLF Extracellular matrix protein 2 Canis lupus familiaris (Dog) (Canis familiaris) LSHNEIRHMP 1 1.5 0.99986 -0.61146 5.66959 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z081 A0A8C0Z081_CANLF Protein kinase domain-containing protein CAMK1G Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] AKSKWRQAFNAA;DISESAKDFICHLLE;GPCGCCSSC;HYYLVMQLVSGGE;LFDRILERGVYTEKDASL 5 14.9 1.003 -0.87133 0 6.78306 0 9.45199 5.41643 0 9.49211 0 0 0 7.45129 0 10.021 0 0 A0A8C0Z084 A0A8C0Z084_CANLF Plastin-3 (T-plastin) PLS3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639] actin filament [GO:0005884]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] AGKPHLVLGLLWQIIKI;LFNKYPALT;LVKSGNLTEDDKHNNAKYAVSMAR;NSLGVNPHVNHLYADLQ 4 10.6 1.0038 -1.0407 9.36297 9.66317 0 0 0 10.4018 0 0 0 0 0 0 0 0 0 A0A8C0Z091 A0A8C0Z091_CANLF LIF receptor subunit alpha LIFR Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] ciliary neurotrophic factor receptor binding [GO:0005127]; cytokine binding [GO:0019955]; oncostatin-M receptor activity [GO:0004924] DLSQKTLRIADL;DTVHHWSWTSDMPLE;GLIIAILIPVAVAVIVGV;NNVEVLETR;SLKRNQRKNRK;TNESYQLFFQM 6 7.5 0.9874 -0.33708 0 0 8.69975 0 0 0 10.6579 0 9.26489 9.59548 4.37865 0 0 0 16.5002 A0A8C0Z0A5 A0A8C0Z0A5_CANLF [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) KDM5C Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872] EGSGKDMPKVQGL;LEQVEGYQ;LEVTLDENHSI;LLTIAERWEEKA;PAREELEPKRL;YHSGFNQGYNFAEAVNFC 6 4.9 0.98928 -0.2606 0 0 0 0 0 0 0 0 9.74957 0 0 0 0 0 0 A0A8C0Z0B6 A0A8C0Z0B6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EQGPGCRTRDFFIFTDRGN 1 15.7 0.95277 0.052533 0 0 0 0 0 0 0 0 0 0 0 0 5.98809 0 0 A0A8C0Z0B9 A0A8C0Z0B9_CANLF Aromatic-L-amino-acid decarboxylase (EC 4.1.1.28) (DOPA decarboxylase) Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520]; carboxylic acid metabolic process [GO:0019752]; catecholamine biosynthetic process [GO:0042423] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] PGVTHWHSPFFFA 1 3.8 0.98841 -0.22601 0 0 0 0 0 0 0 0 10.7013 0 0 0 0 0 0 A0A8C0Z0C0 A0A8C0Z0C0_CANLF Histone deacetylase (EC 3.5.1.98) HDAC5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872] EEEEEEEEEEEECIQ;EEEEEEEEEEEEEEEEECIQ;QEDLEEEEEEEEEEEEEEEEECIQV;QLVMQQQHQQF;QRQQEQRRQEEL;QVEVKPVLP;SAVRMAVGCLVELAF;TLDEIQTVHSEYHTLLY;VTARCFGH 9 8.9 0.9886 -0.34391 7.91558 0 0 0 7.31967 0 9.01611 11.6126 0 7.04374 0 7.84818 0 9.946 0 A0A8C0Z0C3 A0A8C0Z0C3_CANLF Polyadenylate-binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] GVEVGVGVEVGVGMGW;GVEVGWGWGGGGVG;GVGVEWGGVGLPQ;NPQQHLNAQPQ;VGMGWRWGGGGWR 5 8.7 0.99434 -0.073016 0 0 0 0 10.3381 0 0 0 0 0 7.17672 0 13.0508 10.0038 0 A0A8C0Z0C7 A0A8C0Z0C7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PAVNCTVVTQEPSL;TVVTQEPSL 2 10.2 0.94414 0.08273 0 0 0 0 0 0 0 0 0 0 0 4.76808 0 0 0 A0A8C0Z0E4 A0A8C0Z0E4_CANLF MHC class I DLA-12 DLA-64 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DAATGRMEPRAPWVEQ;GSHTFQWMFGCDLGPGGR;IAVGYVDDTQFVRFDSDAA;SVFSCDDSAQGSDVSLT 4 17.4 0.98611 0.046227 0 0 0 0 0 0 6.68173 0 0 0 0 0 0 0 0 A0A8C0Z0E8 A0A8C0Z0E8_CANLF Retinitis pigmentosa GTPase regulator RPGR Canis lupus familiaris (Dog) (Canis familiaris) phagolysosome assembly [GO:0001845] collagen-containing extracellular matrix [GO:0062023] AALLSPPLLLLLLL;ALRAALLSPPLLLLLLLPRVP;LLLLLLLP;LSPPLLLLLLLPRVPPSRASPDT;PPLLLLLL;PPLLLLLLL 6 6.6 0.85911 0.15419 0 0 0 4.01525 0 0 0 0 0 0 0 6.67934 0 5.69808 0 A0A8C0Z0F1 A0A8C0Z0F1_CANLF DnaJ heat shock protein family (Hsp40) member C15 DNAJC15 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ESALRRVL 1 3 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82688 A0A8C0Z0F5 A0A8C0Z0F5_CANLF Dynein light intermediate chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; microtubule-based movement [GO:0007018] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein heavy chain binding [GO:0045504] GSRRRRRRSRRRRRAHSALPGVVW;IITKPPVRKFV;LIRKIQGIEEYKK;VLLLGEDGAGKTSL 4 8.6 0.98806 -0.48953 0 6.45802 0 0 0 4.71907 0 0 8.68517 0 0 4.81747 9.88934 0 0 A0A8C0Z0G1 A0A8C0Z0G1_CANLF "Actin, aortic smooth muscle (Alpha-actin-2)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] AAMCEEEDSTALVCD;DLYANNVL;GDDAPRAVFPSIVG;IMFETFNVPAMYV;LTEAPLNPK;TEAPLNPK;VLDSGDGVTHNVPIYEGYAL 7 20.3 0.95046 0.053874 0 0 0 0 0 0 0 0 0 0 0 7.36737 7.53629 0 0 A0A8C0Z0G3 A0A8C0Z0G3_CANLF 26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) PSMC5 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] PGASGAEVKGVCTEA 1 3.7 0.95451 0.053882 11.5131 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z0G7 A0A8C0Z0G7_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GAGGRAGA;RVHLSNLH;YLGEVAPVGCRGVTARNQG 3 5.5 0.98748 -0.46125 0 0 0 0 0 0 0 0 0 0 0 0 0 8.4947 0 A0A8C0Z0H0 A0A8C0Z0H0_CANLF Spondin-like TSP1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CKKPKKPQRRQNNRLKPLT;EWSEWSPCS;GAQEGCGP;GPRRGVLQLLPLLLLLLLLLL;GVLQLLPLLLLL;GVLQLLPLLLLLL;GVLQLLPLLLLLLLLL;GVLQLLPLLLLLLLLLL;GVLQLLPLLLLLLLLLLLRPGA;GVLQLLPLLLLLLLLLLLRPGAC;HYDYNVTD;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;PLLLLLLLLL;QLLPLLLLLLLLLLL;QLLPLLLLLLLLLLLR;QVCQSSPCEDEESMY;RGVLQLLPLLLLLLLLLLL;VLQLLPLLLLLLLLLL;VLQLLPLLLLLLLLLLLRP 22 5.2 0.85835 0.19159 0 0 6.19519 5.70376 3.93357 0 0 0 0 0 0 4.57858 0 0 0 A0A8C0Z0H1 A0A8C0Z0H1_CANLF Acetyl-CoA acyltransferase 1 ACAA1 Canis lupus familiaris (Dog) (Canis familiaris) bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; very long-chain fatty acid metabolic process [GO:0000038] peroxisome [GO:0005777] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; palmitoyl-CoA oxidase activity [GO:0016401]" GRGGRGGFKDTTPDELLSA;KDTTPDELLSAVMT;SYAVVGVP 3 7 1.0021 -1.2769 8.39502 0 10.6111 0 0 0 9.66704 9.69036 0 0 0 2.91388 0 0 0 A0A8C0Z0I5 A0A8C0Z0I5_CANLF Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; immune response [GO:0006955]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] cell surface [GO:0009986]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; transmembrane signaling receptor activity [GO:0004888] LEVERNCTQTRN 1 3.9 0.94473 0.05044 0 0 9.60004 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z0J5 A0A8C0Z0J5_CANLF TATA-box binding protein associated factor 9b TAF9B Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251] EDDDDDDNDTM;MTDSDEPDEGWSVSEE 2 9.3 0.94727 0.084724 0 0 0 0 0 2.70343 0 8.60099 0 0 0 3.10837 0 0 0 A0A8C0Z0K0 A0A8C0Z0K0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] PIYVTLFSTLGAGH;YQQKPGQPPVL 2 17.2 0.93968 0.10285 0 0 0 0 0 0 0 0 0 0 10.5015 0 0 0 0 A0A8C0Z0K4 A0A8C0Z0K4_CANLF Phosphoglycerate kinase (EC 2.7.2.3) PGK1 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] cytoplasm [GO:0005737] ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] IVWNGPVGVFEWE;LMSHLGRPDGVPMPDK 2 7.5 0.93736 0.064843 0 0 0 0 0 8.68685 0 0 0 0 0 0 0 0 0 A0A8C0Z0M0 A0A8C0Z0M0_CANLF Aminopeptidase (EC 3.4.11.-) Canis lupus familiaris (Dog) (Canis familiaris) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] DRLLRSTILKLAC 1 1.6 0.99126 -0.27542 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7859 0 A0A8C0Z0M2 A0A8C0Z0M2_CANLF Folate receptor-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DCRTSYTCRSDWLGSWDWSRE;EQWWEDCRTSYTCRS 2 13.6 0.94398 0.10159 0 4.66152 0 7.98971 0 0 0 0 0 0 0 8.89785 0 0 0 A0A8C0Z0N0 A0A8C0Z0N0_CANLF C2 domain-containing protein RAB11FIP5 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase binding [GO:0031267] AATAAAASAAAPEATPSGFLG;ASRSSLCVNGSHIY;GLFHHHHQGLSRSE;GPEELPTPPEPAFPP;TLSSASGS;VIQVGREKYSTSV 6 6.7 1.0034 -1.1116 0 9.18718 0 0 0 0 0 0 10.4415 0 0 0 0 11.1338 7.21111 A0A8C0Z0P5 A0A8C0Z0P5_CANLF Beta-arrestin-1 (Arrestin beta-1) ARRB1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968]; protein transport [GO:0015031]; signal transduction [GO:0007165] clathrin-coated pit [GO:0005905]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143] DIVFEDFAR;HFRGSSQGFLQ;KKPLTRLQERLIKKL 3 8.5 0.9818 0.035491 0 0 0 0 0 0 0 0 0 0 6.28455 0 0 0 0 A0A8C0Z0Q1 A0A8C0Z0Q1_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" AGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] ELERWERSQSKNRT;FVNSQEWTL;QSCESSKNKSRLTSQSE;RPDGMQQRSYSV;SLQSCESSKNKSRLTSQ;YHYYSRMANYRNTSEIPLVLVGTQ 6 6.7 0.94204 0.061102 0 7.81461 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z0Q3 A0A8C0Z0Q3_CANLF Platelet endothelial aggregation receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CPPDTYGVGCSARCSCDNAIAC;CPPGWTGHLCLEGCS;DCDHSDGCDP;EGCASRCDCDHSDGCDPVHGHCQC;FSSKEELGASVASL;HPQHGSCSCPP;RSAPWAASARTAPRRATAPWA;TASTDSAARSPAPATRSTAS 8 12.1 1.0035 -0.83663 11.0963 0 8.54183 0 6.20126 0 7.08523 11.2686 10.438 0 0 3.34483 5.01685 0 0 A0A8C0Z0Q5 A0A8C0Z0Q5_CANLF Gamma-tubulin complex component TUBGCP4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasm [GO:0005737]; equatorial microtubule organizing center [GO:0000923]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011] GYPGSIFTWNK;LDQIHGCQIL;TEEDEEDL;VKWRLRNHMAF 4 6.2 0.99986 -0.61146 11.1631 0 0 0 0 2.78205 0 0 0 0 0 0 0 0 0 A0A8C0Z0R8 A0A8C0Z0R8_CANLF Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DGEQPQIL;LEPFVGVLSSHFK;SCHSDQMSNDFSNDDGVDEG;SNDFSNDDGVDEGIC 4 3.3 0.99854 -0.61126 0 0 0 0 0 0 0 0 0 0 0 0 5.37128 0 10.3983 A0A8C0Z0T5 A0A8C0Z0T5_CANLF Nuclear autoantigenic sperm protein NASP AKR1A1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAPEGLNEAKVAS;AAVNAFQEAASL;AFQEAASLLMENGV;EEGKSVCGTDVQDEC;GLAYGYNSQYDEAV;VEQQTNVEELTETKDGS 6 10.1 0.99448 -0.11796 0 9.73716 0 0 0 0 11.182 0 0 0 0 15.632 0 9.945 0 A0A8C0Z0T9 A0A8C0Z0T9_CANLF Proteasome activator subunit 4 PSME4 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499] cytosol [GO:0005829]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111] lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628] ITRVDGKKLLLYREQLVKILQ;ITSFYHPS;LELPWRPLYDMV;LLQFQGSH;PEESLKLFVPH;PGGLFWTRKL;VADMCRAAVKC;VIGVARSLVSGGKWFPEGP;VTQQQFKGALYCL;YFEIFLPTSLPPELHHK 10 7.4 1.0007 -2.7919 11.4067 0 0 8.85624 0 0 6.84009 0 6.54299 0 0 11.5032 0 0 0 A0A8C0Z0U0 A0A8C0Z0U0_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AAQNPAASCAASRS;HDPLHQELSFG;NPAASCAA 3 4.5 1.0017 -1.2119 10.1059 0 0 0 0 0 0 0 10.9363 11.8662 13.6618 11.7074 5.44308 12.0373 12.2864 A0A8C0Z0U4 A0A8C0Z0U4_CANLF Solute carrier family 23 member 2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] DQGVGRVG;NWVNKNPERLHT;TTSYSENIGAL;VGGFLGFFLDNTIPGRAHL 4 8.6 1.0026 -1.8533 0 7.83605 0 0 10.0568 11.187 0 7.93911 7.6978 0 0 7.85381 8.88844 0 0 A0A8C0Z0V5 A0A8C0Z0V5_CANLF Major facilitator superfamily (MFS) profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] DKLQLPGKKVTKASVL;PLSDTLEH 2 4.1 1.0026 -1.3889 0 9.79492 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z0V7 A0A8C0Z0V7_CANLF Zinc finger protein 383 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SPLLGFVI;SRCENKELSLKKDNY 2 4.1 0.99008 -0.20481 8.94971 0 8.5803 0 0 6.01427 0 0 0 0 0 0 0 5.93565 0 A0A8C0Z0W0 A0A8C0Z0W0_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPGEAAAG;FFGLVLALIGLIF;GEAAAGEAAAAG;GGDADPGE;RRLRCASP 5 9.8 1.0022 -1.8643 0 0 4.46159 0 0 0 0 0 0 0 0 0 8.30076 10.9344 9.34742 A0A8C0Z0X8 A0A8C0Z0X8_CANLF MARVEL domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GFSRSLHGGDI;IRGYRKVRKLKEKPAEML;LGGIYYYQFGGAYSGFDG;VLIAAAHVPAL 4 12.4 0.85765 0.16761 0 0 0 6.48837 0 6.1053 10.4767 0 0 6.39335 0 4.80772 0 7.47671 0 A0A8C0Z0Y5 A0A8C0Z0Y5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AERETMPRLPGRAGLLLGVG 1 6 0.96184 0.04875 0 0 0 0 0 0 0 0 0 0 8.59626 0 0 0 0 A0A8C0Z0Y8 A0A8C0Z0Y8_CANLF Solute carrier organic anion transporter family member SLCO2B1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] ATFLPKFLERQFS;GVGTPEAIDG;HVRQECSAPLLHLQSRC;MLRLYVDIDRMPEGG;PELFPACSEPCSCPLDDFNP;VGIMFMAQTLLGVGSVPIQPFGIS;VIHGSAID 7 13.4 1.0036 -2.0485 0 9.30695 9.18038 10.9872 0 0 7.46263 0 7.703 0 0 5.04466 9.58667 0 0 A0A8C0Z0Z6 A0A8C0Z0Z6_CANLF Retinitis pigmentosa GTPase regulator RPGR Canis lupus familiaris (Dog) (Canis familiaris) EWGVREREEKDTEEE;GELEEEGEGELEEGEGK;REEEVGEEEET;SDEDIEIPEEQEGAEDSEGSGIEEQ;SLSNLSSGIVLHQ;VGEEEETEGEGDKEGEE;VGEEEGEGEEEEEGE;VGEEEGEGEEEEEGEEEEGEE 8 9.7 0.97695 0.035538 7.23256 0 0 5.52331 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z0Z8 A0A8C0Z0Z8_CANLF Cholinergic receptor nicotinic alpha 9 subunit Canis lupus familiaris (Dog) (Canis familiaris) neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] NWPHSCISFCWIYFAVSRLRAVET;VISYGCCSEPYP;VVILKYMSRV 3 9.6 0.98897 -0.52308 0 0 0 0 0 0 9.94419 0 0 0 11.4862 0 10.265 0 0 A0A8C0Z107 A0A8C0Z107_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] CESSLQESKQRKDLQDLFS;EDHQSRLEQKLRQKMLKEGEY;EPSEAPLSSSSLS;IDLENIVYYKDC;KFCAGSIDH;LDPLDHRNFY;LLCAENVN;PQTARETPPALGKAQE;SQQRKRRAELKQQREEEGTWKEQE;VGQDMMAVCVL;VLEPPEDQENQK 11 8.9 0.9854 -0.24061 0 0 0 0 0 0 0 0 9.62167 0 0 0 0 0 0 A0A8C0Z112 A0A8C0Z112_CANLF PH domain-containing protein CNKSR3 Canis lupus familiaris (Dog) (Canis familiaris) DEECYSESEQE;EECYSESEQEDPE;IKTQSSLASFSRDR 3 7.3 0.98775 -0.22523 0 0 0 6.72874 0 0 0 0 0 0 0 0 0 0 4.52136 A0A8C0Z135 A0A8C0Z135_CANLF Cell cycle associated protein 1 CAPRIN1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of translation [GO:0017148] cytoplasm [GO:0005737] RNA binding [GO:0003723] EVVNSLQQQPQAASPSVP;LEGKEKSVCGTTYK;QVAEAEPEPAEEYTEQ 3 7 0.99259 -0.051183 0 0 0 0 0 0 10.8711 0 0 0 9.09437 0 0 0 0 A0A8C0Z170 A0A8C0Z170_CANLF Cyanocobalamin reductase / alkylcobalamin dealkylase (EC 1.16.1.6) (EC 2.5.1.151) (Alkylcobalamin:glutathione S-alkyltransferase) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (Methylmalonic aciduria and homocystinuria type C protein) MMACHC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] cobalamin binding [GO:0031419]; oxidoreductase activity [GO:0016491] PEVAELKQKI 1 3.6 0.99978 -0.61146 0 4.7121 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z173 A0A8C0Z173_CANLF PID domain-containing protein DAB1 Canis lupus familiaris (Dog) (Canis familiaris) lateral motor column neuron migration [GO:0097477]; ventral spinal cord development [GO:0021517] cytoplasm [GO:0005737] DPVYQYIVFEA;GVAQDTDDCDDFD;IFDEKTGALQHHHAVH;QDTDDCDDF;TDDCDDFD 5 7.4 0.98527 -0.4305 8.34811 0 6.8716 0 7.9407 0 0 10.6049 5.30129 0 0 0 0 0 0 A0A8C0Z181 A0A8C0Z181_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGTKCCKL;DLTFNHLSR;EDMNGAFS;NKVSYIADCAFRGL;YIFIHLLM 5 4.3 1.0026 -1.7771 9.49877 0 7.99684 0 0 9.81567 0 0 0 0 0 0 0 8.44692 8.7019 A0A8C0Z185 A0A8C0Z185_CANLF RING-type E3 ubiquitin transferase makorin-1 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VIPSEYWVEKEEKQKL 1 4.1 0.99196 -0.036677 0 0 0 0 0 0 0 0 11.9764 0 0 0 10.2011 0 0 A0A8C0Z194 A0A8C0Z194_CANLF Hedgehog acyltransferase Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] ELSFYLCASLGFHFYSFYE;LDGLTPPPLPRCVSTM;LHTLISFCVAQ;YPVFHNGPILSFPEFIAKVQ 4 14.8 0.94802 0.04956 0 0 0 0 0 7.13791 0 0 0 0 0 0 0 0 0 A0A8C0Z1G8 A0A8C0Z1G8_CANLF CCDC144C-like coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AIQDRDQSQASKRDLE;ELAMLRLEIDTIRNQK;QLQSENMLLREQLD;QQLSELQYTR 4 20.1 0.98756 -0.46133 0 0 0 10.8034 10.7561 0 0 0 0 9.75982 0 0 7.83801 0 0 A0A8C0Z1H2 A0A8C0Z1H2_CANLF PML nuclear body scaffold Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] DALHRLRQEEPHDL;DRPLVFFDLKIDSE;PASPGGGV;SFTELLAAHRRDPQQ 4 5.2 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 4.50951 0 4.3817 0 11.3384 A0A8C0Z1H5 A0A8C0Z1H5_CANLF Kremen protein (Kringle-containing protein marking the eye and the nose) Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] AAVSVLLLLLLLSLLRL;AVSVLLLLLLLSLLRLLR;DQICFGHPGQLCGG;EGWAQTPAAPLDGAN;ETGTPQVLLLLLFLPLL;LLLLLLSLLRLLRRRS;LLLLSLLRLLRRRSCLLAPGKGP;SVLLLLLLLSLLRLLR;SVLLLLLLLSLLRLLRRR;TVAAVSVLLLLLLLSLLRL;VAAVSVLLLLLLLSLLRLLRRR;VLLLLLFLPLLP;VLLLLLLLSLLRLL;VLLLLLLLSLLRLLRRRS;VSVLLLLLLLSLLRLL;VSVLLLLLLLSLLRLLR 16 17.4 0.98931 -0.22666 5.53472 0 0 7.00731 7.75642 8.59178 8.17747 8.12226 0 10.0201 6.66292 8.37656 5.54696 0 0 A0A8C0Z1H6 A0A8C0Z1H6_CANLF TAFA chemokine like family member 2 TAFA2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] receptor ligand activity [GO:0048018] ATKGKLLIIIFIVT;SQTVKCSCFPGQVAGTTRA 2 25.2 0.93311 0.060826 0 4.73498 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z1I3 A0A8C0Z1I3_CANLF LIM zinc-binding domain-containing protein LPP Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] APRAWGDEDIAGK;PLDEGTFRAQQ;PPPGLQPEPGY 3 5.3 0.99275 -0.19158 5.05827 0 0 8.97031 0 0 0 0 0 0 0 0 0 0 5.30232 A0A8C0Z1K9 A0A8C0Z1K9_CANLF SH2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DLIEPQKDWLP;PGDTNCEDNV;QQQPVRPHGD;YSNALTEEVTSPAA 4 13 1.0025 -1.1264 0 0 0 0 0 0 5.84659 0 0 0 0 0 10.0344 8.64158 8.01686 A0A8C0Z1L4 A0A8C0Z1L4_CANLF PWWP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGGLLRRKKRRRR;AGGLLRRKKRRRRKRRKRLPRK;DEPEPEPE;DLVFAKMKGYPHWPARI;GGLLRRKKRRRRKRRKRLP;GLLRRKKRRRRKRRKRL;GLLRRKKRRRRKRRKRLPRKML;KKRRRRKRRKRLPRKM;KRRRRKRRKRLP;LLRRKKRRRRKRRKRL;LLRRKKRRRRKRRKRLPR;LLSPALAGGLLRRKKRRR;LLSPALAGGLLRRKKRRRRKRRKRL;LRRKKRRRRKRRKRLPRKMLRPQA;PALAGGLLRRKKRRRRKRRKRLPR;RRRRKRRKRL 16 18.8 0.98772 -0.46122 3.96088 4.05076 10.2655 9.17645 9.00031 0 7.15532 8.58274 6.36147 0 0 7.24365 0 3.80457 8.23707 A0A8C0Z1N3 A0A8C0Z1N3_CANLF Hairy/enhancer-of-split related with YRPW motif protein 1 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] SGGLGPVL 1 2.9 0.9895 -0.26592 0 0 0 0 0 0 0 10.3939 0 0 0 0 0 0 0 A0A8C0Z1P2 A0A8C0Z1P2_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ATSAPGYARFGQG;LSLSLPEIKPLKY 2 4.2 0.94392 0.059632 0 0 0 0 0 0 0 0 0 0 0 4.75441 0 0 0 A0A8C0Z1P9 A0A8C0Z1P9_CANLF E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) CBLB Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; protein ubiquitination [GO:0016567]; regulation of signaling [GO:0023051] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; phosphotyrosine residue binding [GO:0001784]; ubiquitin-protein transferase activity [GO:0004842] HLSLPPVPPRLDLIQK;LDDDDDREESLMMNR;SGQVPLPPARRLPGENVK;WNFLAVTHPGYM 4 6.7 0.98817 -0.47406 0 0 13.0328 0 0 0 0 0 0 0 0 0 0 0 8.68022 A0A8C0Z1Q9 A0A8C0Z1Q9_CANLF PWWP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGGLLRRKKRRRR;AGGLLRRKKRRRRKRRKRLPRK;DEPEPEPE;FLPRAPPRLLGVP;GGLLRRKKRRRRKRRKRLP;GLLRRKKRRRRKRRKRL;GLLRRKKRRRRKRRKRLPRKML;KKRRRRKRRKRLPRKM;KRRRRKRRKRLP;LLRRKKRRRRKRRKRL;LLRRKKRRRRKRRKRLPR;LLSPALAGGLLRRKKRRR;LLSPALAGGLLRRKKRRRRKRRKRL;LRRKKRRRRKRRKRLPRKMLRPQA;PALAGGLLRRKKRRRRKRRKRLPR;RRRRKRRKRL 16 17.7 0.9405 0.059587 0 0 0 0 0 0 0 0 8.82232 0 0 0 0 0 0 A0A8C0Z1R1 A0A8C0Z1R1_CANLF Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) DAG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509] LGYPVVGWHIANKKP;SFRVTIPMDLIASNGEL;VVSSACAA 3 4.7 0.99227 -0.16582 9.52005 0 0 0 8.97355 0 0 9.42677 0 0 0 8.51598 0 0 0 A0A8C0Z1R8 A0A8C0Z1R8_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] ADLEVFIKNSE;ADSLKETY;DEEERKVAVIMLEVKQKQKDCE;DLDFKELAYDAQ;EAKHCFANIC;ETAAVLFSSREFYRQ;GNKKLIYF;IKITNEPP;IPILANEKNHLDWPH;IQQASNYL;KEMSYLEPRQ;NALSQQVQQMHGE;PLQHLAAMFSEVVI;QHLDYGHWYDRN;QPEMQAQATL;SIDPHQVLDARHTEIQ;VGSAGTGK;VLCGDLPA;YVFNLRDFANIFQGI;YYIDPETKKFEPWSKLIPQFEFDP 20 5.6 0.99808 -3.3286 6.60024 11.9984 7.34607 6.75995 4.53144 11.5116 13.5583 10.1941 12.7364 10.6492 9.73786 10.0942 12.0103 7.10098 20.3868 A0A8C0Z1R9 A0A8C0Z1R9_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EESEEDVLFSNMEEEHESWDESDEE;GQKDQLRFGVDSWS;ISSSTPNSPVTSPAL;LSSDHQEKES;NLSEIKFNSYN;PFDENPELKEKEYTRAD;RAAMIPPKHPRQP;SLSSDHQEKE;STERKRGSVA;SYELKGLDIESYDSLE 10 7.9 1.002 -1.2189 10.364 0 8.75812 0 4.84609 0 10.6263 7.90135 8.00405 0 0 0 10.9292 0 10.1752 A0A8C0Z1S2 A0A8C0Z1S2_CANLF "Isocitrate dehydrogenase [NAD] subunit, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] "magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" PEPCFARTPPPPRT;VAAPPRWRRRRRQRRRRRRCPRRKG 2 5.7 0.9914 -0.27754 0 0 0 0 0 0 0 6.60764 0 0 0 0 0 0 0 A0A8C0Z1S3 A0A8C0Z1S3_CANLF PPFIA binding protein 1 PPFIBP1 Canis lupus familiaris (Dog) (Canis familiaris) DLEFCLEEHREKLNA;QKSSSLGNLKKES;RDTEGLMQEINDLRLRVSEMDNERL;SFEENDGKIIL;TAEHLDLAGISSR;VLEPRFNVETMAQ;YEKQRMEQKW 7 9.7 1.0031 -1.6572 9.87813 0 11.8127 0 0 0 0 0 0 0 7.40438 0 0 0 15.0661 A0A8C0Z1U5 A0A8C0Z1U5_CANLF Uncharacterized protein HNRNPUL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEEEEEEDEEALLEDE;DRFYGRDYEYNRYRDYYRQYNRDWQ;EDDEEEEEEDEEALLE;EEDDEEEEEEDEEALLEDEDEEPPP;FYDRYRGDYDRFYGRDYEYNRYRDY;GGPGGDEEDDEEEEEED;NFYDRYRGDYDRFY;NSGQRRKL;PKTIEECEV;PPSEKRTNRRNNRNKRNRQ;SEKRTNRRN;YDRYRGDYDRFYGRDYEYNRYRDYY 12 14.5 1.003 -1.583 9.04745 0 7.56826 0 14.3622 0 9.35165 0 8.91427 0 8.19618 6.71383 0 0 0 A0A8C0Z1W1 A0A8C0Z1W1_CANLF Serpin B6 SERPINB6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EGTEAAAASA;SLSKSGGG 2 5.5 0.9919 -0.54025 0 0 0 9.85375 0 0 0 0 0 9.24781 0 0 0 0 0 A0A8C0Z1W5 A0A8C0Z1W5_CANLF Xyloside xylosyltransferase 1 XXYLT1 Canis lupus familiaris (Dog) (Canis familiaris) UDP-xylosyltransferase activity [GO:0035252] HPELFHVLDC;PALRERGGQPRGGQ;RHTFWQFRH;VLVAAAAAAAA 4 5 0.99667 -0.57215 0 9.15636 0 5.22562 0 0 0 0 0 0 3.19552 0 0 0 0 A0A8C0Z1X6 A0A8C0Z1X6_CANLF SRCR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zymogen activation [GO:0031638] extracellular space [GO:0005615]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ATSAPGYARFGQG;CSHNGWNSHNCRHSED;GVCYHDQQ;SEDAGVIWTES 4 7.1 1.0034 -1.1044 0 0 0 0 0 8.69742 0 0 0 0 0 0 0 0 0 A0A8C0Z1Y5 A0A8C0Z1Y5_CANLF Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) GNAS Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606] heterotrimeric G-protein complex [GO:0005834] beta-2 adrenergic receptor binding [GO:0031698]; corticotropin-releasing hormone receptor 1 binding [GO:0051430]; D1 dopamine receptor binding [GO:0031748]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; insulin-like growth factor receptor binding [GO:0005159]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; mu-type opioid receptor binding [GO:0031852] EDPQAARSNSDGEK;LGETVKEAGAH 2 2.6 0.98749 -0.50397 0 0 0 0 0 0 0 0 0 0 0 0 7.72881 0 0 A0A8C0Z1Z0 A0A8C0Z1Z0_CANLF Peroxisomal testis enriched protein 1 PXT1 Canis lupus familiaris (Dog) (Canis familiaris) GACLWPRARSWRPGI;HSLPSQPKES 2 15.8 0.99971 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.10203 A0A8C0Z1Z1 A0A8C0Z1Z1_CANLF Pejvakin PJVK Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] LRESWQGISSYQ;MESIRTTRQCSLSVH 2 8.2 0.95261 0.05044 0 0 0 0 0 0 0 0 0 0 0 9.09297 0 0 0 A0A8C0Z205 A0A8C0Z205_CANLF COP9 signalosome complex subunit 2 COPS2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] CDDEEDYD;DMEDDFMCDD;EDDFMCDDEED;ELEGEKGEWGFKALKQ;SDMEDDFMCDDE;SDMEDDFMCDDEE 6 7.1 1.0024 -1.7516 6.83137 6.84449 0 0 0 0 0 10.6199 4.02077 0 3.59967 0 6.12728 0 0 A0A8C0Z247 A0A8C0Z247_CANLF "RAB17, member RAS oncogene family" Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVVVMLVGNKTDLG;SGSVGKSS;VGPARCCA;VVMLVGNKTDLGEQ 4 15 1.0019 -1.2483 3.03434 0 8.69822 0 0 8.82575 0 0 0 0 11.1541 0 9.00812 0 0 A0A8C0Z256 A0A8C0Z256_CANLF Anaphase-promoting complex subunit 5 (Cyclosome subunit 5) ANAPC5 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein ubiquitination [GO:0016567] anaphase-promoting complex [GO:0005680]; cytoplasm [GO:0005737]; spindle [GO:0005819] ESLYFNPMMTNGV;YGRSLRYAALNLA 2 3.5 0.98685 -0.38202 0 0 11.5875 0 0 0 0 13.6714 0 0 0 0 0 0 0 A0A8C0Z277 A0A8C0Z277_CANLF F-box domain-containing protein FBXL6 Canis lupus familiaris (Dog) (Canis familiaris) SCF ubiquitin ligase complex [GO:0019005] AADGPVPFLGR;ALLGSCCPQLQVLEVSTG;LHDLPCQELEQL;PGAKARPRMAPAPEPPP;QELEQLHLGLYG 5 12 0.43396 0.50944 13.264 13.2758 13.0329 0 4.67796 8.63757 12.6806 0 12.7317 0 10.1385 9.87518 7.85568 12.2189 5.29447 A0A8C0Z299 A0A8C0Z299_CANLF Tetratricopeptide repeat domain 21A TTC21A Canis lupus familiaris (Dog) (Canis familiaris) FIERTFMATSSY;FVEAIEVCHN;GHYDKAREYIDCNLKLSNNSREGL;GVTWCQILEGHLEE;IDCNLKLSNN;KKEDVMETLNKAMDLQ;LHLKKILVVSRL;LSGELENAQSTLQRCLE;VMQDAINEFSGTPEEIRITIA 9 10.2 1.0025 -1.1637 11.4749 8.45224 8.94442 0 0 0 0 10.3955 6.71397 8.80935 0 8.15005 4.11053 0 0 A0A8C0Z2D6 A0A8C0Z2D6_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VILRISSTEGRSKAFSAC 1 6 0.97231 0.048313 0 0 0 0 0 0 0 9.39819 0 0 0 0 0 0 0 A0A8C0Z2E6 A0A8C0Z2E6_CANLF Phosphodiesterase (EC 3.1.4.-) PDE5A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" AAVVPSAQTLKITD;DEDCSDSFSSVF;IVDEDCSDSFSSVFHMECEE;SEGTVSFLA;VERAMAKQ;VILKKIAA;VILKKIAATIISFMQVQK;VKKNYRKNVAYHNW;VVGVAQAINKKS 9 12 0.99869 -2.9945 9.25574 3.49275 0 8.75519 0 6.67525 14.5266 5.08015 6.0043 0 3.89181 0 6.33735 13.5015 5.72778 A0A8C0Z2F5 A0A8C0Z2F5_CANLF Cleavage and polyadenylation specific factor 1 CPSF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676] DTSGFATQGPTV;HVDRRILQNAVRNVLDGEL;LNRDAEAPVKNDRS;TSGFATQGP 4 3.1 1.0012 -0.70672 0 0 0 0 0 0 10.4776 0 0 0 7.67624 0 0 9.49572 11.559 A0A8C0Z2F8 A0A8C0Z2F8_CANLF IF rod domain-containing protein IFFO1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] GPAAYSPPGPGPAPPAAMALRNDL;LSINEEMQRML;QRMLNQLREYDFEDDCDSLTWEETE 3 10 0.98712 -0.38351 0 0 9.30376 0 0 0 0 11.1658 0 0 0 0 5.4987 5.79095 3.7995 A0A8C0Z2G1 A0A8C0Z2G1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] NLRNASSRERR;PGNSQEEGQPTPALWSS 2 3.9 0.94336 0.083219 0 0 0 0 0 0 0 6.12926 0 0 2.32184 0 0 0 0 A0A8C0Z2G8 A0A8C0Z2G8_CANLF Condensin complex subunit 1 NCAPD2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821] condensed chromosome [GO:0000793]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654] histone binding [GO:0042393] AAVSTVLDPEEE;DESSEEELSAEM;ISPEELLKSGRVNQYVVQEILSIKH;LSRDPVGTKGFAAFLTE;LVQYLQDAYSFSLK;VCKNAIQLLASF 6 6.6 0.99134 -0.30132 0 6.00108 0 8.66078 7.73179 0 0 0 12.0892 7.71266 0 7.24108 0 0 12.7883 A0A8C0Z2H0 A0A8C0Z2H0_CANLF dual-specificity kinase (EC 2.7.12.1) Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] QLTHTDLK;SAPEISVQKVYMPLLQ 2 5 1.0044 -1.0519 0 0 0 0 0 0 9.14484 0 0 0 0 0 0 0 9.46258 A0A8C0Z2I0 A0A8C0Z2I0_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CTSCYSCPDLWMRYGNH;IYSVWQWSTE 2 14.4 0.99324 -0.18756 9.24667 0 0 0 0 0 0 0 0 0 0 0 0 0 4.79468 A0A8C0Z2I6 A0A8C0Z2I6_CANLF Sorting nexin Canis lupus familiaris (Dog) (Canis familiaris) cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320] cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] AMDDGVKE;DDDEWDEDWDDP;DEWDEDWDDP;DKQVTGRFEEEFIKMRMERLQAWMT;NSSAANSNNQVSSSNDPWSA;QVTGRFEEEFIKM;TGDDDEWDEDWDDPKS 7 11.6 1.0035 -0.87644 4.21576 4.23695 0 5.38056 0 0 0 0 0 0 0 4.38239 0 0 10.597 A0A8C0Z2J3 A0A8C0Z2J3_CANLF Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (S100 calcium-binding protein A10) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TIPCNDYFVIHMKQKGK 1 17.5 0.97863 0.046227 0 0 0 0 6.06119 0 0 0 0 0 0 0 0 0 0 A0A8C0Z2M7 A0A8C0Z2M7_CANLF Interleukin 1 receptor accessory protein IL1RAP Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] hydrolase activity [GO:0016787]; interleukin-1 receptor activity [GO:0004908] SASSGWNESCSSQSDISLDH;YTVELACGFGATVLLVVILIV 2 6.4 0.99007 -0.20046 0 0 0 0 0 0 0 9.7077 6.22066 0 0 0 0 0 0 A0A8C0Z2M8 A0A8C0Z2M8_CANLF Mitogen-activated protein kinase 8 interacting protein 1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of JNK cascade [GO:0046328] cytoplasm [GO:0005737] ADDSQEAKGNK;LELEVDDPLLVELQ;VELQAEDYWYEAYNMRT 3 5.4 0.98713 -0.40654 0 0 9.20882 0 0 0 0 0 0 0 0 9.59455 0 9.32562 8.77489 A0A8C0Z2P4 A0A8C0Z2P4_CANLF N-terminal amino-acid N(alpha)-acetyltransferase NatA (EC 2.3.1.255) RENBP Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] NatA complex [GO:0031415] peptide alpha-N-acetyltransferase activity [GO:0004596] APRPLARPRSAPPRGRVPPPVSR 1 3.8 0.97984 0.04627 0 0 4.07818 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z2P8 A0A8C0Z2P8_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2A2 Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] AWWFIAAD;EGRAIYNNMKQ;FILDRVEGDSCSLN;IGCYVGAA;LVTDGLPAT;VIMITGDNKGTDEDVTSK 6 6.8 1.003 -1.6295 0 0 0 0 0 0 0 11.2443 0 12.0989 0 0 10.0794 0 0 A0A8C0Z2Q0 A0A8C0Z2Q0_CANLF Coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AQVLIVVVITPILVCRDFAVL;DQPQSRRARELGSGV;GGSARPQPPGVPRHK;QARLQTRSPH;RAPAFLSPLSLRTG 5 7.4 0.99647 -0.58283 0 0 0 0 0 0 0 10.4264 0 0 0 0 0 0 0 A0A8C0Z2Q3 A0A8C0Z2Q3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] TSRWSKYWKQSKYPST 1 6.1 0.96152 0.049233 0 0 0 0 0 0 9.83887 0 0 0 0 0 0 0 0 A0A8C0Z2R5 A0A8C0Z2R5_CANLF Rho guanine nucleotide exchange factor 9 (Collybistin) (Rac/Cdc42 guanine nucleotide exchange factor 9) ARHGEF9 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] GQIDDEEGWFPASFVRLWV;IYSEYCNNHLDAC;LQNRDQMRANVINEIMSTE;PKRSQSPFWQ;VSAEAVWDH;YSEYCNNHLD 6 12.7 1.0033 -1.568 9.81133 0 8.30675 0 0 0 0 0 0 7.17702 7.75148 8.33217 7.04843 0 0 A0A8C0Z2W0 A0A8C0Z2W0_CANLF TAP binding protein like TAPBPL Canis lupus familiaris (Dog) (Canis familiaris) QSTTELGEQSCASHP 1 6.8 0.99198 -0.14062 0 0 0 12.5567 0 19.038 0 0 0 0 0 0 0 0 0 A0A8C0Z2X2 A0A8C0Z2X2_CANLF MRH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CKESEYHYE;GIQACIPCGPG;IEENATMS;IIEENATMSFTWAFQRT;NGSDCSHCP;SVPLKTSSGGP;VLYWRTTAFSVG 7 7.5 0.99745 -3.4069 9.28556 8.87652 8.17936 0 0 0 0 0 0 0 0 8.33838 0 0 0 A0A8C0Z2X6 A0A8C0Z2X6_CANLF CHCH domain-containing protein CHCHD10 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] TCRLTTSL 1 4.2 0.98912 -0.2641 0 0 0 0 0 0 0 9.03801 0 0 0 0 0 0 0 A0A8C0Z2Y5 A0A8C0Z2Y5_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLFNLLFFILGA;SSWGCSCPSACAG;VSSWGCSCPSA 3 8.2 0.99133 -0.20601 0 0 0 5.52525 0 0 8.93219 0 0 0 0 0 0 0 0 A0A8C0Z2Y6 A0A8C0Z2Y6_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NPRRQIAMWHQ;TLGTATSI 2 4.5 0.98712 -0.22811 0 0 9.03243 0 0 0 9.81766 0 0 0 0 0 0 0 0 A0A8C0Z319 A0A8C0Z319_CANLF Nuclear mitotic apparatus protein 1 N-terminal hook domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] FLSGSPASPMGDILQ;KTKEAEQTCRH;LEEKNEILQGLSQLEEHLAQLRD;QLSELQAQLNQKEQAAEHYKLQM;QQPVPERLEFV;QVAHADQQLRD;VASSSGNNFLSGSPA;YSTQSAPASQAGPRATS 8 12.2 0.97908 0.046276 0 0 0 0 0 8.01753 0 0 0 0 0 0 0 5.47716 0 A0A8C0Z323 A0A8C0Z323_CANLF AHNAK nucleoprotein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] APKISMPDFDL;EAPDVSLEGPEGKL;IMNIQTHKISMP;SLPNVEGDLKG 4 5 0.9545 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 4.65151 0 0 A0A8C0Z338 A0A8C0Z338_CANLF tRNA-queuosine alpha-mannosyltransferase (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) GTDC1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] ALRPDLGKLKKIL;LSKRLQNFC;RPDIIRKHLYKLYGY;TSASVRLDICEERN 4 10.8 0.95056 0.053874 0 0 0 0 0 8.15876 0 0 0 0 0 0 0 0 0 A0A8C0Z342 A0A8C0Z342_CANLF Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) ELAC2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial nucleoid [GO:0042645] 3'-tRNA processing endoribonuclease activity [GO:0042781]; metal ion binding [GO:0046872] DTMSEYSG;LHADHHTGLLNILLQRE;LPKHHPDA;VGVRMNAGFTMLNHFSQR;VPRLSAPLKA 5 6.5 0.9986 -3.0176 9.24982 0 0 0 0 0 8.99506 10.12 0 8.28221 7.00315 0 0 0 4.07271 A0A8C0Z375 A0A8C0Z375_CANLF Nephronectin Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509] PSGPIHVPKGN;SLPSRDLNEC;SYCYCLNGYMLMPDGSCS 3 6.5 0.9897 -0.52765 0 0 0 0 0 0 0 9.61456 0 0 0 9.6202 0 0 0 A0A8C0Z379 A0A8C0Z379_CANLF t-SNARE coiled-coil homology domain-containing protein VTI1A Canis lupus familiaris (Dog) (Canis familiaris) "Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]" cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] ARELLEQMDLEVREIPPQSRGMYS;MLENLSHDREKIQRARER 2 19.4 0.9384 0.089615 0 0 0 0 0 0 0 0 8.03227 0 0 9.0119 0 0 0 A0A8C0Z384 A0A8C0Z384_CANLF Kinesin motor domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] spindle pole [GO:0000922] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ASRLLTTVEETTKD;GAAKRTTAATLMNAYSS;GSLTSVPENVSI;GVPAEFLREEERGE;HFNQEGTKLVEESMKHCDKLNSNL;KHCDKLNSNL;LLMMLKCSENNKEEI;RNKRGVIIKGLEEITVHN;SPNEEYTWEED;WEEDPLAGI;YGTQFCADCDG 11 12.6 1.0034 -1.5492 9.3735 9.11637 0 8.10758 10.07 0 10.9257 11.0132 0 0 0 0 3.37601 8.85396 9.89468 A0A8C0Z3B5 A0A8C0Z3B5_CANLF Pleckstrin homology domain containing A5 PLEKHA5 Canis lupus familiaris (Dog) (Canis familiaris) reproductive system development [GO:0061458] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" ARYYINHNER;FSKEFKKTEDIF;QSPSVLRDNP;RNQMQEQLDRLGEVQTESAGIQRAQ;VLIKPEVQ;VMARYPEGYR;YKSEPELTTV;YYRDEKEEGILG 8 7.6 0.99928 -0.61146 0 0 0 0 0 0 0 0 0 0 0 9.89368 0 0 0 A0A8C0Z3C3 A0A8C0Z3C3_CANLF C2 domain-containing protein CPNE4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277] plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544] FVPFRNFKHASPAALAKSVLAEV;MHSFLDYIMGGCQIQFT;PFLEIFRMNDDATQQLVH;RVGRRMKKMS;TKEASQYFILLILTDGV 5 14.8 0.98809 -0.37515 0 7.77406 0 0 0 0 0 0 0 0 9.44677 0 10.2511 8.47841 7.16501 A0A8C0Z3D1 A0A8C0Z3D1_CANLF "Small ribosomal subunit protein bS16m (28S ribosomal protein S16, mitochondrial)" LOC102155750 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] HPMMITNAERLRRKRAREVL 1 15.9 0.97324 0.048206 0 0 0 0 0 0 0 8.60474 0 0 0 0 0 0 0 A0A8C0Z3E8 A0A8C0Z3E8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IKIPWSFFKELEQI 1 1.8 0.98953 -0.22238 10.9863 0 0 0 4.2601 0 0 0 0 0 0 0 0 0 0 A0A8C0Z3E9 A0A8C0Z3E9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] DDEEEEPC;IKDLQEVKSKPKKKKK;IQEDSATEDKFYSLDELHILD;NMEPSSSDLSKS;QDDDDEEEEPC;QRIELEELQNEEEELSPPL;VTHMAASNLESL 7 7.9 0.98804 -0.47725 0 0 0 4.72982 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z3G6 A0A8C0Z3G6_CANLF RFX-type winged-helix domain-containing protein ARID2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677] FLDELRQFHHSRGYLEKYEKVH;GKIQSEANQCSLI;IVDDNEVRDLISDRNKSH;LDELRQFH;LDELRQFHHSRGYLEKYEKVHHFG;MPPTGGVQ;QDEPGQAGSQK;VGNHFQRTSVTNQ 8 4.9 1.0039 -2.029 0 8.0468 0 0 10.8229 6.40978 9.38185 0 9.13768 11.9448 8.36269 0 0 0 0 A0A8C0Z3H1 A0A8C0Z3H1_CANLF LEM domain-containing protein EMD Canis lupus familiaris (Dog) (Canis familiaris) nuclear envelope [GO:0005635] HGCCHCMPPVCCH 1 5.3 0.93952 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 4.97852 0 0 A0A8C0Z3J2 A0A8C0Z3J2_CANLF WD repeat-containing protein 46 WDR46 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] PGRDVQPKKARLQTKKKKPRRYWEK 1 4.4 0.97759 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 8.88728 0 0 A0A8C0Z3J9 A0A8C0Z3J9_CANLF Alpha-type protein kinase domain-containing protein TRPM7 Canis lupus familiaris (Dog) (Canis familiaris) protein tetramerization [GO:0051262] membrane [GO:0016020] ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] EFLSKEEMGGGL;EVRILDSN;NPMLFHLVRDVKQ;PTDAYGVINFQGG;TKPEVILQLLLKEWQMEL;VGDALKEHASRSSR;VLHLCLREIQQQRAAQKLT;YLGFLMLYTF 8 5.8 0.99344 -0.070442 0 9.69352 12.2583 5.61462 0 0 0 13.4698 0 0 12.5571 5.87504 9.01923 11.3121 0 A0A8C0Z3K6 A0A8C0Z3K6_CANLF BSD domain-containing protein BSDC1 Canis lupus familiaris (Dog) (Canis familiaris) SPCEENPVT;VGSQREDVGWW;VISDTFAPSP;VLPKDLSQK 4 8.5 1.0027 -2.1844 10.2402 0 0 0 0 0 0 0 0 0 3.23025 8.08746 12.8561 0 0 A0A8C0Z3L4 A0A8C0Z3L4_CANLF Flavoprotein domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] catalytic activity [GO:0003824] TGSVAALKLPLLVSRLLDIPG 1 16.4 0.97467 0.047166 0 6.42757 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z3N6 A0A8C0Z3N6_CANLF F-box protein 8 FBXO8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] guanyl-nucleotide exchange factor activity [GO:0005085] YFMSKGILDDS 1 3.8 0.98494 0.035491 0 0 0 0 0 0 0 0 0 6.5719 0 0 0 0 0 A0A8C0Z3N7 A0A8C0Z3N7_CANLF CW-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] IVALQKALEDVEAKYK 1 2.4 0.95834 0.049233 14.4297 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z3V1 A0A8C0Z3V1_CANLF Protein kinase domain-containing protein PSKH2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LGVITYVLLSGVLPFDDESHTR;QKQPDNPKFCVVMPRNESLGDL;VARFRAHFH 3 14.9 1.0013 -0.70837 0 0 0 0 0 0 5.51643 0 6.89676 0 0 5.3965 0 0 0 A0A8C0Z3V9 A0A8C0Z3V9_CANLF Methyl-CpG binding domain protein 5 Canis lupus familiaris (Dog) (Canis familiaris) chromocenter [GO:0010369]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] DRQMRPPKPK;IVTTAAGNPLQSQLPIGSDFP;KVWVIWFGLHAF;LSQSGMALGNSLHPNP;LSSNSTPGCGGSNTALPC;NPLQSQLPIGSDFP;PAIQVPVG;PLSPPSVMLHGSPVQSSC;VGWQRRVDQ 9 7.3 0.95451 0.05044 0 0 0 0 0 0 0 0 0 0 0 5.39732 0 0 0 A0A8C0Z3W3 A0A8C0Z3W3_CANLF VWFA domain-containing protein CACNA2D1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] calcium channel activity [GO:0005262] EEDPSLLWQVF;SQEPVTLDFLDAE;VFIDDANFGRQISYQ;YVPSVADILHIGWWAT 4 5.6 0.8 0.20944 0 4.69661 0 0 0 9.69895 0 0 0 10.4946 10.5237 4.93182 0 0 10.4504 A0A8C0Z3X3 A0A8C0Z3X3_CANLF Solute carrier family 11 member 1 SLC11A2 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] metal ion transmembrane transporter activity [GO:0046873] MADDDASGDHGDSPSLGT 1 3.4 0.97282 0.048313 0 0 0 0 0 0 0 4.19125 0 0 0 0 0 0 0 A0A8C0Z3Y3 A0A8C0Z3Y3_CANLF Stabilin 2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540] DNAATNGV;DPGAHMGP;GPDCQPCRCSDHGQCDD;GVCNSGIDGDGSCECYSA;GVGCSMAD;GVGCSMADVCESKNPCHRNAN;HYHNYMPGVGCSMA;IDGDGSCECYSAYTGS;NACETSNGGCSS;NEALDNMKDGTL;NGVIHVISKVLIPRRSL;QSHCECKEHY;RGSCAEGMEGNGRCSCQDG;SGDGSCDC;VLIPPAECVRTGT 15 6.8 1.0026 -1.3583 0 0 8.30387 0 0 0 0 0 0 7.8871 0 0 0 7.45804 0 A0A8C0Z424 A0A8C0Z424_CANLF Frizzled class receptor 10 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AGDELTGVC;MAASIPAVEIFMVKIFMLLV 2 5.2 0.98982 -0.26368 0 0 0 0 0 0 0 5.44606 0 0 0 0 0 0 0 A0A8C0Z448 A0A8C0Z448_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CEILQLFKISCTDPRVN;MEANKTQVTEFVLIGLT 2 10.9 0.80662 0.21615 0 0 0 4.93348 10.7025 0 0 0 11.3995 0 0 0 10.3172 10.5631 11.3725 A0A8C0Z461 A0A8C0Z461_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] PGSTGSRS 1 1.2 1.0042 -1.1044 0 0 0 0 0 0 0 8.70619 0 0 0 0 0 0 0 A0A8C0Z463 A0A8C0Z463_CANLF WAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EDTCVVSCNSDDNCPQGTKCCP;VPFIAHPSPV 2 21.3 0.98943 -0.21927 6.03675 0 0 0 0 9.2085 7.78182 0 0 0 0 0 0 0 0 A0A8C0Z467 A0A8C0Z467_CANLF Acyl-CoA 6-desaturase (EC 1.14.19.3) (Fatty acid desaturase 2) FADS2 Canis lupus familiaris (Dog) (Canis familiaris) unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" HYAGEDATSQITEDF;LGEWQPIE;NFQIEHHLFP;VLGEWQPIEYGKK;VNMLHVFVLGEW 5 11.1 0.98767 -0.3619 11.7774 8.34261 0 0 0 0 11.3621 8.69777 8.73985 10.9111 9.71156 7.22863 8.94337 10.8159 9.98342 A0A8C0Z475 A0A8C0Z475_CANLF Disintegrin and metalloproteinase domain-containing protein 1a-like Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CDCGPDCG;CDCGPDCGNNLCCDQTCH;CKDTCDYAEQ;DEQCDCGPDCGNNLCCDQ;DLELMPVTEGPLCVRLGVL;EDEQCDCGPDCGN;EEDEQCDCGPDCGNNLCCDQ;FPVFSYHNGV;GVLEEDEQCDCGPDCGNNLCCD;QCDCGPDCGNNL;RSAPEDCYI;VEEERQEEEEEEEEEEEEEEEEEEE;VLEEDEQCDCGPDCG;VRLGVLLLLVLIF 14 13.4 1.0036 -1.6837 0 10.7321 10.5147 0 5.82184 10.2247 0 11.7157 10.3496 0 0 3.38446 0 8.75902 7.15684 A0A8C0Z476 A0A8C0Z476_CANLF Histocompatibility minor 13 HM13 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" APIKLVFPQDLLEKGLEADN;SLPPTFPSCSHQNWSPCQNPSCQ 2 12.6 0.97844 0.046273 0 0 0 0 0 0 0 0 0 0 5.19767 0 0 0 0 A0A8C0Z493 A0A8C0Z493_CANLF HORMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] chromosome [GO:0005694]; nucleus [GO:0005634] AHQGLDFDEEEEECNNHI 1 9.9 0.98096 0.048313 0 0 0 7.50216 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4A1 A0A8C0Z4A1_CANLF Large ribosomal subunit protein eL29 (60S ribosomal protein L29) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] CSCSCSCSCFYSCSAGS 1 7.7 0.9774 0.046227 3.88421 0 0 0 3.0649 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4A2 A0A8C0Z4A2_CANLF Ankyrin repeat domain 33B Canis lupus familiaris (Dog) (Canis familiaris) AGDRPQRPGH;DTGLGWPLQERTASGGWG;PEDAPCVG;PGPAPGPS;VSADAVPTPGRS 5 7.8 1.0016 -1.4138 11.2339 13.8997 0 0 0 0 11.8444 0 13.8573 0 0 0 0 0 13.3341 A0A8C0Z4A6 A0A8C0Z4A6_CANLF Ankyrin repeat domain 33B Canis lupus familiaris (Dog) (Canis familiaris) GARRVSPQTPSP;PEDAPCVG;RRSSTKDSAHLQL;TAVGRTGVGVRV;VGVRVPRGIRSGP 5 5.8 1.0031 -0.83883 9.14349 0 0 0 0 0 0 0 0 0 0 0 0 5.38636 0 A0A8C0Z4B3 A0A8C0Z4B3_CANLF LY6/PLAUR domain containing 6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical Wnt signaling pathway [GO:0090263] acetylcholine receptor inhibitor activity [GO:0030550] CGFCADPG 1 1.8 1.0039 -1.1044 6.70625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4B4 A0A8C0Z4B4_CANLF Protein kinase domain-containing protein MAPKAPK5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TOR signaling [GO:0032007]; Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019] CGYPPFYS;EESDMEKAIKET;LMTPQFTP;RLHMMCATHPNIV;SEMAKDVVRKLLKVK 5 13 1.0018 -0.66272 0 10.2983 0 0 0 0 0 0 0 0 0 0 0 13.3132 12.8355 A0A8C0Z4B9 A0A8C0Z4B9_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2E1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] PFPLKPYKHL 1 3.8 0.9892 -0.26514 0 0 0 0 0 0 0 0 10.6778 0 0 0 0 10.1514 0 A0A8C0Z4C0 A0A8C0Z4C0_CANLF 5-hydroxytryptamine receptor 1F (Serotonin receptor 1F) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993] IVSTIYSTF;LPFFVKELV;LSDPSTDFDKI;REDPGGGV;SVDITCCTC;VGRKEGLQFSNLISRRYKP 6 14.2 1.0027 -2.1826 0 0 0 0 10.3588 9.98883 0 0 0 0 10.3373 0 0 0 0 A0A8C0Z4C2 A0A8C0Z4C2_CANLF Meiotic double-stranded break formation protein 4 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; meiotic DNA double-strand break formation [GO:0042138] EVNSFTDVLAT;NHLNRFQVQHFVSQSLV;NPLFSHMQFLQ;QASYVTRYENIFSLF;SEQESTWRSKVQVLE 5 17.9 0.98775 -0.37574 0 0 0 0 0 0 0 8.72768 9.75836 0 0 0 9.77523 11.6169 8.66651 A0A8C0Z4D5 A0A8C0Z4D5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MNEKGEITTNT;PSICCLQETHFRQ;RKGCPLSP 4 5.8 0.98462 -0.23937 0 0 0 9.47804 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4D6 A0A8C0Z4D6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) PPIL2 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457]; protein polyubiquitination [GO:0000209] catalytic step 2 spliceosome [GO:0071013] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ubiquitin protein ligase activity [GO:0061630] DEPFSRQD;PLGSSSRWFQICGL;STAMVPET;VLLFCEGPDGISSFVASW 4 9.7 1.0023 -1.2455 0 0 7.59096 0 5.10689 6.33501 0 0 0 0 0 0 0 0 6.52453 A0A8C0Z4E8 A0A8C0Z4E8_CANLF Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 DAPP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] SCFRNWAGSDCGQNPQG;VPTAPSLG 2 8.6 1.0036 -1.0582 0 0 0 0 0 0 11.468 0 0 0 0 5.68633 0 0 0 A0A8C0Z4G5 A0A8C0Z4G5_CANLF V-set and transmembrane domain containing 4 VSTM4 TMEM273 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GIRWQYRWLLEKRRT;VSCFLCVLLRSVLTLLPRE 2 9.4 0.99283 -0.13276 0 7.78549 10.8846 0 0 0 0 0 0 0 0 0 11.422 0 11.8189 A0A8C0Z4I2 A0A8C0Z4I2_CANLF RP1 like 1 Canis lupus familiaris (Dog) (Canis familiaris) AHSKSGEGLPCSGIS;DTVVREWLSNIPE;EEFCPCEACMR;ESPGPQGAGQGSRECHSRLKA;FHLLGKDAVLWSRRVGRASALP;GTDSRRRSRLTQHS;PGSRYEIWMNPL;QNDGDKSEEIQ;RWEMSLQTEQRRRR;SSADCGPGRGELGE 10 9 0.99138 -0.13336 0 8.64357 0 0 0 0 0 10.0768 0 0 0 0 0 0 0 A0A8C0Z4I8 A0A8C0Z4I8_CANLF Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG UNG1 Canis lupus familiaris (Dog) (Canis familiaris) "base-excision repair, AP site formation via deaminated base removal [GO:0097510]" mitochondrion [GO:0005739]; nucleus [GO:0005634] uracil DNA N-glycosylase activity [GO:0004844] VLQTAHPS 1 2.7 1.0038 -1.1044 0 0 0 0 0 0 5.9181 0 0 0 0 0 0 0 0 A0A8C0Z4K2 A0A8C0Z4K2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] DTTVQNLWDAAKAVLRGKYIS;FFEKINKIDKPLANLIKKKREKTQI;PSICCLQETHFRQ 3 7.7 0.9462 0.084254 0 7.03782 0 0 9.27771 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4L3 A0A8C0Z4L3_CANLF Ripply transcriptional repressor 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] PKLVPKKLKGKQII;VKPKLVPKKLKGK;VKPKLVPKKLKGKQI 3 9.2 0.86116 0.1742 2.33965 0 0 0 0 0 0 0 0 0 0 0 4.64051 0 4.01881 A0A8C0Z4M4 A0A8C0Z4M4_CANLF RasGEF domain family member 1B RASGEF1B Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EQQWKLPMYSSITPVCFTSPLIE 1 4.2 0.97693 0.046415 0 9.84197 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4M6 A0A8C0Z4M6_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] EPFSHLAIWGSI;FVWPTIPVAPEMT;FWMPMKMLEHGNGFIVS;VISISYLQPHWF 4 5.6 0.98557 -0.4362 0 12.5335 0 0 0 8.91175 0 0 0 0 0 0 0 0 0 A0A8C0Z4N0 A0A8C0Z4N0_CANLF Dynein heavy chain tail domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959] AVLMSCSLGFMEP;PGEAPPPSDEEGQR;VLMSCSLGFMEPRHKAGTGRQSQKG 3 6.8 0.99285 -0.2716 0 0 0 0 0 9.03284 0 0 0 0 0 0 0 0 0 A0A8C0Z4N8 A0A8C0Z4N8_CANLF Wolframin ER transmembrane glycoprotein WFS1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] FENEQEVKQLSSETDLE;NFGWNHLEPYVHF;NLFLQDDDDDE;VIPPHGGQCGKLCVAP 4 5.9 0.98784 -0.37696 0 0 0 0 0 0 9.87052 0 9.87016 0 0 0 4.98673 0 0 A0A8C0Z4P0 A0A8C0Z4P0_CANLF Olfactory receptor OR1D6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] INELVVYTLGSCLFV;VYLRPSSSYTIE 2 8.7 0.9876 -0.48262 0 0 0 7.27668 0 0 0 10.8908 0 0 7.48406 8.12846 7.71473 7.68748 0 A0A8C0Z4P2 A0A8C0Z4P2_CANLF von Willebrand factor (vWF) VWF Canis lupus familiaris (Dog) (Canis familiaris) cell-substrate adhesion [GO:0031589]; platelet activation [GO:0030168] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; Weibel-Palade body [GO:0033093] collagen binding [GO:0005518]; identical protein binding [GO:0042802] CCPTCHCGSC;CEGNTSSCGDQPSEGCF;CPCYYDGE;DCTCFCDT;DEYECACNC;DHHTMCYCEDGFM;DIFSDHHTMCYCED;LGYKEEKNQGECCG;LHVKEVCQEQCVDGCSCPEG;LSYPEEDCNEVC;MCYCEDGFMHCT;NPSDPEHCQ;QDQCSCCSPTQTE;RLARNLVRYVQGLKKKKVIV;RNLHENGY;SECCPTCHCGSCCLADSL;TQCCDEYECACNCVNSTVSCP;VDELEQRRDEII;WNCTDHVCDATCSA 19 7.8 0.99487 -0.56314 0 0 0 0 0 0 6.71205 6.40997 0 0 0 0 0 0 0 A0A8C0Z4P7 A0A8C0Z4P7_CANLF dual-specificity kinase (EC 2.7.12.1) DYRK2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] GPARPPRSPCRLSGPATL;ILEHLRKQDKD;RLSGPATLRPRRTRILPL;RQAAEEIRILEHL 4 7.1 0.98529 -0.44108 10.9604 0 5.54825 0 0 0 0 0 12.5742 0 0 0 0 0 0 A0A8C0Z4Q5 A0A8C0Z4Q5_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) EVSQSEKDNI 1 1.5 0.98321 -0.25668 0 0 0 0 0 0 0 0 0 0 0 9.38793 0 0 0 A0A8C0Z4R7 A0A8C0Z4R7_CANLF BTB domain-containing protein BACH1 Canis lupus familiaris (Dog) (Canis familiaris) GVRDIEESCFQFLRFKFLDSTAD;KGSGSAACGPGQ;TTLSSVNCPFISTLSTEG 3 7.8 0.99149 -0.27699 0 0 0 0 0 0 8.16491 0 0 0 0 0 0 0 0 A0A8C0Z4R8 A0A8C0Z4R8_CANLF Insulin like growth factor binding protein 6 IGFBP6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] insulin-like growth factor binding [GO:0005520] PAEGCAEAGG;PRRLLPPLLLLG;RRLLPPLLLLGLLLA 3 10.9 1.0029 -0.88232 0 10.3185 0 0 3.55078 0 0 10.4296 10.5241 0 0 0 0 0 0 A0A8C0Z4S5 A0A8C0Z4S5_CANLF RRM domain-containing protein HNRNPDL Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleoplasm [GO:0005654] RNA binding [GO:0003723] AQRHVTAQ;NSAAMEDMNEYSNIEEFAEG;SQNWNQGYSNY 3 9.6 0.98981 -0.21576 0 10.5432 0 0 0 0 0 0 0 0 0 11.0582 0 0 0 A0A8C0Z4T3 A0A8C0Z4T3_CANLF Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) KIZ Canis lupus familiaris (Dog) (Canis familiaris) spindle organization [GO:0007051] centrosome [GO:0005813]; cytoplasm [GO:0005737] ECCASENECSQ;ISASECCASENEC;PHSHRQPARSGDVTDSCVGQI 3 6.6 0.98388 -0.24289 0 0 0 0 0 0 7.54628 0 0 0 0 0 0 7.45426 0 A0A8C0Z4T6 A0A8C0Z4T6_CANLF Aquaporin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ACSPRTWCRHGAGCP;LRRPEQSGWSTLP;PEEQVPNPEKEAGPGAGSHP;PVYRVPAVA;VTVMAYAAGP 5 10.7 0.99276 -0.29016 0 0 0 8.84257 0 6.53562 0 0 0 0 0 0 0 6.89845 0 A0A8C0Z4W0 A0A8C0Z4W0_CANLF Inhibitory synaptic factor 2A INSYN2A Canis lupus familiaris (Dog) (Canis familiaris) inhibitory postsynaptic potential [GO:0060080] postsynaptic density [GO:0014069] ETIKVLLGVIQE;GPEPALPG;RFKDICEAQNEQR 3 7.3 0.98782 -0.48029 0 9.22954 0 0 4.34341 0 0 0 9.3927 0 0 0 0 0 0 A0A8C0Z4W3 A0A8C0Z4W3_CANLF Plakophilin 3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] IRTTGTPEAGVCSLALPSD;LLYFDGLRKLVFIKKKR;LRKLVFIKK;RGPLDFLAHR;RRLRELPLT;VNIIAVLNNLVVA 6 8.4 0.99426 -0.56159 0 5.69039 9.67569 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4W5 A0A8C0Z4W5_CANLF Cadherin domain-containing protein PCDH15 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; sensory perception of sound [GO:0007605] plasma membrane [GO:0005886]; stereocilium [GO:0032420] calcium ion binding [GO:0005509] DSEEESEPGSSGSSSSSSS;ESETPSEEEESST;QEEATESTVESEEESSSDYT;SSTPESEESESTESE;VIKEKAKKIKKPKV;VIKEKAKKIKKPKVEI 6 12.3 0.91618 0.11 0 2.97924 4.5612 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4X5 A0A8C0Z4X5_CANLF Synaptotagmin like 2 SYTL2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] small GTPase binding [GO:0031267] ETWDWDNKQNK;HSPAGHLP;NSFVKCIILPDTSRKSRQKTR;SEVLTARPESI;STVPSQPDNP 5 6.2 0.98889 -0.26277 0 0 0 0 0 0 0 5.31136 0 0 0 0 0 8.9429 0 A0A8C0Z4Y8 A0A8C0Z4Y8_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) RFVRNQKRPRIARGILKKK 1 2.8 0.95405 0.04941 0 4.926 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z4Z5 A0A8C0Z4Z5_CANLF complement subcomponent C1r (EC 3.4.21.41) Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] DIALLELENSVTLGP;EVSAEPLG;GHSCQAEC;IPLSQKLFG;IPLSQKLFGEVTS;IPLSQKLFGEVTSPLYPK;IPLSQKLFGEVTSPLYPKPYPNNL;LFFTDESGDSRGW;PQCQHLCHNYVGSYFCTCRPG;SLEENLQP;TYQARIQYYCQE 11 13.8 1.0022 -1.0008 10.9599 10.4347 6.66206 9.97126 6.2183 10.0073 11.9338 11.8265 9.38552 13.1156 11.0823 10.9826 13.4311 13.4485 13.2764 A0A8C0Z4Z6 A0A8C0Z4Z6_CANLF Telomere-associated protein Rif1 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" CDMDSEEATS;DPEEKVIKQECI;DSELLEQISPLL;EDGDSTKISTIPVEAETKTS;ETSQSRTS;EVWWYLLMRLGP;IDNFALNPEI;LCSKMMSSLEDSGF;NFSAIYGALTLPIHH;PRMNLSSNLGGMATIPSI;SEVERDLK;SFAKQNKLVLSLEP;SLFKLIVRVI;SPQKLRELDPLF;STKGFLSP;TELKENPT;VGELDEGSDESGPGSS;VKLKLESSSSKTKSEMPL 18 9.2 0.96456 0.049233 0 0 0 0 0 0 0 0 6.00394 0 0 0 0 0 0 A0A8C0Z506 A0A8C0Z506_CANLF Nucleoporin 58 NUP58 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear pore [GO:0005643] nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056] EVQLQQYRQQIEE;NTLNIDKLKIETAQ;TTITTGLTLGTPATTSTSTTGFS;VKEQKQVQEEIS 4 11.4 1.0009 -0.6315 9.4626 0 10.395 10.8525 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z510 A0A8C0Z510_CANLF WW domain binding protein 11 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] spliceosomal complex [GO:0005681] DDSDTDRSDGESEGDEFVHRDDNER;EDDSDDSE;EVEEFSEDDDEDDSD;QDKHDDSTDDSDTDRSD;QDKHDDSTDDSDTDRSDGE;REVEEFSEDDDEDDSDDSEVEKQSQ;SEDDDEDDSDDSEV;SEDDGYPEDMDQDKHDDSTDDSD 8 10.8 1.0019 -1.4155 0 7.45162 7.55934 8.66633 0 5.82049 0 6.184 0 10.6115 0 0 0 0 5.1946 A0A8C0Z513 A0A8C0Z513_CANLF C2H2-type domain-containing protein ZNF804A Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AGTSGIAG;DEKYTTTRSKGTH;ELCDKQYYK;GANKDYGPEMMS;KKKRKKLC;PALRAGPAPGARAA;SEETTKDVTTVAAD;VLNKDGSTVLQWPSE 8 7.3 1.0028 -2.5606 0 0 7.52309 0 5.75425 0 0 0 10.4958 11.5395 0 8.58673 0 7.91181 0 A0A8C0Z525 A0A8C0Z525_CANLF Heparin binding growth factor Canis lupus familiaris (Dog) (Canis familiaris) EEQQQREEQLQ;GGGGGGGA;GGGGGGGG;MMPCARWNPPGCGG 4 9.1 0.98794 -0.49413 0 0 0 0 0 8.39489 0 0 0 9.53706 0 0 0 0 0 A0A8C0Z533 A0A8C0Z533_CANLF Acid sensing ion channel subunit 1 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280] DFLVEKDQEYCVCEMPC;EQKKAYEIAGLLGD;NSESEEEEEEKEQ;PGDAPYCTPE;QEYCVCEMP;RVAYYLSYPH 6 11.5 1.0043 -1.0967 7.19052 0 7.97682 0 0 0 0 0 8.27491 0 0 10.8405 0 0 0 A0A8C0Z537 A0A8C0Z537_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) LOC111093854 Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] HHRINFDKYHPGYFGKVGMRHYHL;PKQPVIVKAKFFSRRAE;RNEQTRVNATKNKTGAAP 3 39.1 0.86658 0.13584 0 0 0 6.80826 0 5.59479 0 0 0 0 0 0 9.64144 0 0 A0A8C0Z549 A0A8C0Z549_CANLF Myosin XVIIIA MYO18A Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAIEDEMESDENEDL;ERLFSYYGPQEGDKKGQR;GWLSYTKQNPA;HKDGFSLGSQLKSEELSLP;HKRRKKGRSRKSKKKSKSRRKRTE;KKHELEMDLE;KQMEVQLEEEYEDKQ;QEFEDKLEVEQQ;RLEMEMERMRQTHSKEVE;SEEDDRKSIQSVR;TGMAAVKKKSL;VALSEAHS;VQLEEEYEDKQ 13 7.4 1.0025 -1.747 10.0618 0 0 8.19086 13.2311 0 4.56041 0 12.6576 0 0 10.9462 0 0 10.4892 A0A8C0Z567 A0A8C0Z567_CANLF Roundabout guidance receptor 1 Canis lupus familiaris (Dog) (Canis familiaris) axon midline choice point recognition [GO:0016199]; Roundabout signaling pathway [GO:0035385] axon guidance receptor activity [GO:0008046] DVDLSNKINEMKTFNSPNL;GPLVSDMD;KARPAKKQ;PNAIYLFLVRAANAYGISD;SDMDTDAPEEEEDE;SPPHTYGYISGP;VVISVSKSG 7 5.3 0.99894 -3.1477 9.61983 0 0 0 4.84122 0 8.96913 0 0 0 8.99164 0 10.3452 6.67835 0 A0A8C0Z577 A0A8C0Z577_CANLF Phosphatidylserine synthase (EC 2.7.8.29) (Serine-exchange enzyme) Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylserine biosynthetic process [GO:0006659] endoplasmic reticulum membrane [GO:0005789] L-serine-phosphatidylethanolamine phosphatidyltransferase activity [GO:0106245] FQTVQDGR;GKASLEEPPDG;LPEPGDPP;LPPEHYLVLLRLVFFVNV;PGDPRGDPLAAGD 5 7.1 1.0015 -0.9188 0 0 6.35595 0 0 0 0 0 0 0 8.273 7.67221 0 4.92144 0 A0A8C0Z583 A0A8C0Z583_CANLF Dedicator of cytokinesis 9 DOCK9 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] ATEVCLTALDTLSLFTLAFK;DAQKLDFTSAEP;GNMNSAISVTMRSF;LHAMEGHVMIAFLPTILN;PVLQDILQEAAMQYPKQGIFSVTC;VAQCHEEGLES;VESNDTPVDLQLDYS;VGMQDVHFNEDVL;YSHSTCQRRR 9 6.4 0.99075 -0.53747 8.59854 10.0206 7.61802 0 0 0 0 0 10.1614 7.23688 7.17273 0 0 0 0 A0A8C0Z584 A0A8C0Z584_CANLF Glutamate receptor GRIN2B Canis lupus familiaris (Dog) (Canis familiaris) excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291] NMDA selective glutamate receptor complex [GO:0017146]; postsynaptic membrane [GO:0045211] metal ion binding [GO:0046872]; NMDA glutamate receptor activity [GO:0004972] LITFICEHLFYWQFR;SVWAFFAVIFLA;YQMHPKLVIILLNKERKW 3 3.3 0.94029 0.10219 0 0 0 0 0 0 7.32202 0 8.13155 0 0 0 0 0 0 A0A8C0Z594 A0A8C0Z594_CANLF 40S ribosomal protein S21 RPS21 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EMVDKVTGRFNGQ;GRGASFLRWSSWWRQQVRPRH;PAHTAAGGR 3 13.4 1.0026 -0.77136 0 0 0 0 0 0 13.7753 9.64348 0 0 0 0 0 9.10085 0 A0A8C0Z595 A0A8C0Z595_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) IKKIDKPLANLIKKKR;MDAFLESHKL;MNEKGEITTNT 3 3.7 0.95892 0.049233 0 0 0 0 7.57137 0 0 0 0 0 0 0 0 0 0 A0A8C0Z5B4 A0A8C0Z5B4_CANLF Fanconi anaemia group A protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] EVICCPLRDPSLT;LFMRDEREAVDFL;PLLSSLYRRLFVMLS;SALAGRSQELQGQGDPVG 4 4.5 0.88369 0.13037 0 0 0 7.69808 0 0 0 0 0 0 0 0 0 6.08096 0 A0A8C0Z5B9 A0A8C0Z5B9_CANLF Collagen type IX alpha 3 chain Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] CFPTGAPG;GVPGREASE 2 4.7 1.0038 -1.1044 0 0 0 0 0 0 2.73409 0 0 0 8.8364 0 0 0 0 A0A8C0Z5C2 A0A8C0Z5C2_CANLF Radical SAM core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] "4 iron, 4 sulfur cluster binding [GO:0051539]; GTP binding [GO:0005525]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]" DVGFDPGLQ;EVQRPEVQLGRSSD;FDPGLQDRALAKG 3 6 0.98845 -0.22398 0 0 0 0 0 0 0 0 0 0 7.02303 0 5.43446 0 0 A0A8C0Z5D1 A0A8C0Z5D1_CANLF Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) SEC31A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum membrane [GO:0005789] AQNDKHTGPVRALDVNIFQTNL;ENQYMQDQAPMLE;SEFLPSAGGTFN;VEKLVACWTKAQ;VGVLLAEKMSQYANL;YPNTPYISPASSYSGQSQ 6 7.3 0.98823 -0.47178 6.37752 0 0 0 0 0 7.61353 0 6.08108 10.041 0 13.3911 0 0 0 A0A8C0Z5F9 A0A8C0Z5F9_CANLF Keratin 76 KRT76 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] ALDIEIATYRT;DIEIATYRT;EQSWQESYF;GASGGACGF;GPGGFGGL;GVGGFGSRSLYSLGG;ISVAGGSR;QVKTQEREQIKTL;TELQAKVDSLTDELNF 9 14.5 0.99653 -4.9922 0 7.45796 10.7199 9.69281 0 0 0 0 0 0 10.4897 7.36588 9.97398 8.75572 0 A0A8C0Z5G9 A0A8C0Z5G9_CANLF HSR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LPFRKLMCSL 1 7.5 0.98442 -0.24724 0 0 0 0 0 10.6074 0 0 0 0 0 0 0 0 11.4708 A0A8C0Z5I2 A0A8C0Z5I2_CANLF Calponin-homology (CH) domain-containing protein CCDC88A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705] centrosome [GO:0005813]; cytoplasm [GO:0005737] dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017] EGNASKIL;EQLEKENKSL;ESLEKENSQL;GLARSMWTKYKKAEI;GVFLNQVMLQ;INPKSESQRVNKKVNNDAS;KSAHKNLEVE;LARSMWTKY;LQQLIMMSLPNVLI;MKLESVGIAK;NWITLKMRKLIKSKKDINRERQKSL;QLDITSTKLNNQCELLSQ;SILVRQIKFYYQE;SNKAPNSITHYM;SVSSDFLGKNK;TLQTQNAKLQVE 16 11 1.003 -2.3437 11.935 9.01084 9.99181 0 0 0 10.9136 11.3382 10.2498 12.3649 0 3.44943 0 5.73509 4.87189 A0A8C0Z5K3 A0A8C0Z5K3_CANLF Transient receptor potential cation channel subfamily V member 4 TRPV4 Canis lupus familiaris (Dog) (Canis familiaris) ER to Golgi ceramide transport [GO:0035621] cytoplasm [GO:0005737] lipid transfer activity [GO:0120013] IETGPFLEAVSHLP 1 23 0.99066 -0.13825 0 0 11.0649 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z5K6 A0A8C0Z5K6_CANLF "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" ALDH5A1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" VCSNRFLVQRGIHDSFVK;VGGRWLPAAAAFPVHDPAS 2 7.2 0.93623 0.097873 10.3568 0 0 0 6.35708 0 0 0 0 0 0 0 0 0 0 A0A8C0Z5M3 A0A8C0Z5M3_CANLF Ryanodine receptor 3 RYR3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AWKEILNLLYKLLAALIR;CCRFLCYFCRISRQNQKAMFEH;CQSGEDEEEEEDK;EEEEDEDSSYMLEIE;EEEEEDEDSSYM;EGTREKVLQNDEFTR;GGEGWGGNGVGDDLYSYGF;GLGDIMNNKVFY;IEECLLAICNH;IISTVDYL;IRNTTALFSQF;ISLAKARY;LINDVTSIRPNIFLGVAEGSAQYKK;LSVSNGNIQ;NGNIQVDASFMQTLWNVHP;NILKIINN;PEEEEEEDEDSSYMLEIEG;PLIRPFKT;PTTLKELISQTMI;QCLEPLQMMALH;SEIIGKDEP;SHKKYDPD;SKEIKEKLDSSHKRDIEG;SSMMAKSCQSGEDEEEE;TERSKLEDDPLY;VDVLELCEQEDLMYFHYHTLR;VNEKTQYNRLI;VRHRISLFGSDSTTMVSCLH;YHILCSLYSLGTGKNIYVER;YMLEIEGEEEDS 30 7.8 0.99677 -5.3243 7.25739 0 8.54187 8.71094 7.6512 9.57128 10.4336 6.98596 11.9952 5.74122 10.5096 11.4137 5.92809 0 9.83496 A0A8C0Z5M9 A0A8C0Z5M9_CANLF Delta-1-pyrroline-5-carboxylate synthase [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] ALDH18A1 Canis lupus familiaris (Dog) (Canis familiaris) L-proline biosynthetic process [GO:0055129] mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350] LFDQIIDMLRVE;NQLKEMAIPVLE;PLFDQIIDMLRV;PRGSSQLVRDIQ;QSVRQALHSGQNQL 5 6 1.0009 -0.93166 0 10.6551 5.97854 0 10.2508 0 0 0 9.49957 0 0 0 0 0 0 A0A8C0Z5R3 A0A8C0Z5R3_CANLF Mediator complex subunit Med12 domain-containing protein MED12 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] beta-catenin binding [GO:0008013]; transcription coregulator activity [GO:0003712] FGLGPSKDGHEISSD;LDTQAPMLT;LLKLLLPLL;LLKLLLPLLLR;LLLPLLLR;NQPAVSGDEH;SAGPGRRLWRYGLG;VEVRWSFDKCQE;VNNWRDDQYL 9 3.6 1.0035 -1.6077 8.84693 0 0 4.34156 0 0 6.67271 0 11.1562 0 0 9.73772 0 9.70945 9.16098 A0A8C0Z5S4 A0A8C0Z5S4_CANLF Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (Ecto-ATP diphosphohydrolase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) ENTPD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] NYHFDFQGARIITGQEE;SRYAHKLSEIDIYLTECMIRAS;WEELKTYF 3 10.2 0.99246 -0.16856 0 0 0 0 9.03097 0 0 7.96475 0 0 0 0 0 6.56487 6.77043 A0A8C0Z5S8 A0A8C0Z5S8_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] KPAKPLPKE;LFADQADNI;VQSSGENGIV;WEYYECVEKLCKDVVL 4 8.3 1.0031 -1.0244 0 0 0 7.8936 8.13443 0 0 11.4645 9.17143 0 0 0 8.90773 0 0 A0A8C0Z5U5 A0A8C0Z5U5_CANLF DNA-directed DNA/RNA polymerase mu (EC 2.7.7.7) POLM Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via nonhomologous end joining [GO:0006303] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] APILPGATVT;DVDLLLSHPQE;EQTSAEEASHWQ;MLPKRRRAQ;SLSEALEMLAE;VGGGACWG;VQELLEQGVCEEVERV 7 14.4 1.0035 -2.4477 0 0 0 5.80728 7.05333 7.63234 0 0 10.2115 8.5916 0 0 15.1232 0 0 A0A8C0Z5U6 A0A8C0Z5U6_CANLF Sodium/potassium-transporting ATPase subunit beta-1-interacting protein (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein) Canis lupus familiaris (Dog) (Canis familiaris) regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] LSPHRSWWL;VSVFTEEEDSCL 2 15.4 0.99031 -0.2676 0 0 0 0 0 0 0 0 0 0 9.59231 0 0 0 0 A0A8C0Z5V9 A0A8C0Z5V9_CANLF LisH domain-containing protein ARMC9 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] DDDEDEDDEEDHDTMEAD;DDEEDHDTMEADLDKDEL;DEDDEEDHDTME;ESDDDEDEDDEEDHD;ESDDDEDEDDEEDHDTMEADLDKD;GVLESDDDEDEDDEED;GVLESDDDEDEDDEEDHDTMEAD;GVPSQAPG;LLDGVLESDDDED;SEVVRQYMARLI 10 6.9 0.99707 -0.094546 0 5.06121 10.6304 0 0 6.88056 9.57613 2.62898 0 0 5.70625 11.9515 0 0 6.5023 A0A8C0Z5X5 A0A8C0Z5X5_CANLF Tubulin alpha chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] AVFVDLEPTVIDEV;DIERPTYTNL;DVVPKDVNAAIA;EKAYHEQLTVAEI;GDVVPKDVNAAIA;SSITASLRDGALNVDLTE;THTTLEHSDC;TVVPGGDLAKVQ;VFVDLEPTVIDEV 9 20.1 0 2.2345 9.91498 9.1335 9.32053 0 0 0 9.97528 10.0729 9.21585 10.6054 9.90974 10.5753 0 0 0 A0A8C0Z5Y0 A0A8C0Z5Y0_CANLF Cilia and flagella associated protein 65 CFAP65 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EAGCCGAC;EEEEEEEEEEEEMEEEE;EEEEEEELEEEEEEEEEEEEMEEEE;ELEEEEEEEEEEEEM;EVQATCWYG;LPPIRNQQP;LVHHQDPLFLDLIGTCHSDSTKP;PVPLYLMNHTKGKITVVW;TFNLAPQS;VDLRATLPCHNL;VGEEEEKSEEEEEEEELE;VLHFGSVSVGCTVER;VSPMTGKVAPE 13 8.3 1.0035 -1.5468 9.33891 0 0 9.59779 0 7.9567 0 9.31924 12.4267 0 10.3528 6.31139 13.6815 0 0 A0A8C0Z5Y1 A0A8C0Z5Y1_CANLF Intraflagellar transport 88 IFT88 Canis lupus familiaris (Dog) (Canis familiaris) DEDDLYSG;DSSCTEALYNIGELYDSEGD;SMGRPMTGAIQDGV 3 5.5 0.98532 -0.24124 10.3403 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z606 A0A8C0Z606_CANLF "V-type proton ATPase subunit B, brain isoform (Vacuolar proton pump subunit B 2)" ATP6V1B2 Canis lupus familiaris (Dog) (Canis familiaris) ATP metabolic process [GO:0046034]; vacuolar acidification [GO:0007035] clathrin-coated vesicle membrane [GO:0030665]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] "ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LAYQCEKHVLV;RAMRGIVNGAAPE 2 5 0.93904 0.059702 0 0 0 0 0 0 0 9.49065 0 0 2.1399 0 0 0 0 A0A8C0Z610 A0A8C0Z610_CANLF DUF4605 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AERPVAGTEPEPGASP;GGGGGGGE;GGGGGGGG 3 8.1 0.98709 -0.2333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.10478 A0A8C0Z615 A0A8C0Z615_CANLF Leucine zipper tumor suppressor 1 LZTS1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] FSEDIPALQRELER;LVTPVGPT;QQLKESQTEINTKASEI 3 6.6 1.0023 -1.3702 0 0 0 0 0 0 0 0 0 0 0 0 7.9318 9.46191 0 A0A8C0Z620 A0A8C0Z620_CANLF Protein kinase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] WTSSPRTSCWMPTTTSSFAI 1 2.7 0.96382 0.048688 0 0 0 0 0 0 0 0 0 0 0 0 0 5.16011 0 A0A8C0Z622 A0A8C0Z622_CANLF Tubby-like protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] DENRKAKTHTGRGRSR;NDHESLLSKWQNKTMEN 2 8.1 0.92634 0.09546 0 0 0 0 0 8.2914 0 7.03188 0 0 0 0 0 0 0 A0A8C0Z628 A0A8C0Z628_CANLF SEFIR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] interleukin-17 receptor activity [GO:0030368] LPCLCIEASYL;LPRLLRALDAQ;PQPLRALPRYRLLRDLPRLLRALDA;RALPRYRLLRDLPRLLR;SLGQDGFVPPV 5 7.2 0.99398 -0.071896 0 0 3.92048 0 0 0 5.07562 5.87985 0 0 6.94872 0 0 0 0 A0A8C0Z633 A0A8C0Z633_CANLF Nucleolin Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" nucleolus [GO:0005730]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677]; RNA binding [GO:0003723] AAAPASDEEEDDE;AAAPASDEEEDDEEDDDE;AAAPASDEEEDDEEDDDEDDDEE;AAPASDEEEDDEEDDDEDDDE;DDDEDDDEEDEDEDEDDSE;DDEDDDEEDEDEDEDDS;DDSEEEDEEDEDEDEDEFE;DEDEDDSEEEAMET;DEDEEDDDEEEEDEDDDEE;DEEDDDDS;DEEDEDEDEDDSEEEAME;DSEDEEMSEDEDDDSSGE;EDDDEDDDEEDEDEDEDDSE;EDDEDEEDDDEEEEDEDDDEE;EDEDEDEDDSEEEAMET;EDSDEEDDDDSEEEDEE;EDSEDEEMSEDEDDDSS;EEDDDDSEEEDEEDEDE;EEDDDDSEEEDEEDEDEDEDEF;EEDEEDEDEDEDEF;EEDEEEEEEEEEEEPVKEAPG;IVTDRETGSSKGF;KEDSDEEDDDDSEEE;KEDSDEEDDDDSEEEDEEDEDEDE;KGIAYIEFKTEADA;PASDEEEDDEEDDDE;PASDEEEDDEEDDDEDDDEEDED;PPPKEVEEDSEDEEMSEDEDDDSS;SDEEEDDEEDDDEDDD;SEEEDEEDEDEDEDEFE;TAEDEDEEEDDED;TAEDEDEEEDDEDEE 32 23.6 1.0004 -0.61882 5.88952 8.3302 10.9668 6.0108 8.44228 7.57221 6.50472 10.5187 10.7546 5.53528 3.94476 0 0 6.54739 8.83876 A0A8C0Z636 A0A8C0Z636_CANLF Neuralized E3 ubiquitin protein ligase 1 Canis lupus familiaris (Dog) (Canis familiaris) CPPVLPGG;DTVIYTCGHMCLC;LVSQSGFWAKALPEEF;PIDSIGGPFPVTSH;SGAARPGALS;SLCDLNVPGADGDGDGDDA 6 12.4 0.99231 -0.20715 0 0 0 0 0 0 4.88181 0 0 0 0 0 0 11.181 0 A0A8C0Z637 A0A8C0Z637_CANLF Keratin-associated protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] SLSYGSRFCRPTF;SPANMSYSCC 2 10.7 0.99242 -0.55161 0 0 0 5.25882 0 0 11.535 0 0 0 0 0 0 0 0 A0A8C0Z643 A0A8C0Z643_CANLF DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) SEC23B Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase III [GO:0006383] RNA polymerase III complex [GO:0005666] ESKKLIKAVK;LTEINKILKNLESKKL;VFDDCHEGGEISP 3 10.8 0.93933 0.059587 0 0 0 0 0 0 0 0 0 0 0 0 0 8.23156 0 A0A8C0Z659 A0A8C0Z659_CANLF Gamma-aminobutyric acid type A receptor subunit beta1 GABRB1 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; nervous system process [GO:0050877]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594] GGSPGPRRPAPPDPPLQSH;PMSPNVSHLPAGPPVDVGMR;SEVNMDYTLT 3 9.4 0.99123 -0.51184 0 5.53235 0 0 0 0 0 0 10.0137 6.78346 0 0 0 0 0 A0A8C0Z665 A0A8C0Z665_CANLF Homeobox domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAPGEALHSAPKAASD;AAPRGGGG;AATGFGSP;DLEDDEDDDEEGERDLA;GCAPPGLPAAATPASSGA;PRGGGGGK;SGSECKDKYDDLEDDEDDDEEGER 7 16.7 0.99947 -2.8954 0 8.0182 10.6854 0 0 0 0 6.31529 8.19382 10.2968 11.3098 0 0 11.2084 7.57818 A0A8C0Z666 A0A8C0Z666_CANLF Regulator of microtubule dynamics protein 2 (Protein FAM82A1) RMDN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922] QKSNIFPDHQQGRANFDFQEKRNS;SNYLYLAKCYIDLEQA;SRRESKNLCSPSNASF 3 10.8 0.99448 -0.16169 0 0 7.13761 8.04002 0 0 0 8.3062 0 0 0 0 0 0 0 A0A8C0Z668 A0A8C0Z668_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ubiquitin protein ligase activity [GO:0061630] LITLKLKTK;LRNAMLWFE 2 3.9 1.0033 -1.6084 3.77821 0 0 0 0 0 4.24588 0 0 0 0 0 0 0 0 A0A8C0Z694 A0A8C0Z694_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EDECLFQKFKITD;FIVFKIFLHTEGHGNKYFN;NNYWRKLDLKNIPRTMIIYDIVD 3 16.5 0.991 -0.14785 10.6821 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z6A6 A0A8C0Z6A6_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT3 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] GLGGNQGI;LMQREVSIQYSKEES;NPVISGYIKSIGQPLC;VGHVFRSKSPHT 4 7.9 1.0029 -0.73703 0 0 0 0 0 0 0 0 0 0 0 9.075 8.98168 0 0 A0A8C0Z6C6 A0A8C0Z6C6_CANLF Galactosidase beta 1 like Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] beta-galactosidase activity [GO:0004565] VFYVPWNYHEPEPG;YNFNGSRDLFAFLKE 2 5.2 0.87762 0.12618 8.15163 0 0 0 0 0 8.44919 0 0 0 0 0 0 0 0 A0A8C0Z6D1 A0A8C0Z6D1_CANLF Homeobox domain-containing protein MEIS2 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TPHPTQLRHGPPMH 1 3 0.93696 0.060957 0 0 0 0 0 0 0 0 0 0 7.72778 0 0 0 0 A0A8C0Z6D2 A0A8C0Z6D2_CANLF Nop domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) box C/D methylation guide snoRNP complex [GO:0031428]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] snoRNA binding [GO:0030515] DEIIEKKAKKAKIKK;DKVDTMIVQA;EEQETSVK;EGKINKQLKKVLKKIVK;GVENRAKLEARLR;IEKKAKKAKIKKVE;INKQLKKVLKKIVK;KKKKKKKK;KKVLKKIVKEAHEPL;LKKVLKKIV;LPTCSKKRKI;QLKKVLKKIVK;SVGYAIFKVLNEKKLQEVDSLW 13 20.9 1.0026 -1.4855 0 0 12.582 5.49099 5.29488 0 9.39498 0 4.9594 4.24641 0 0 0 0 0 A0A8C0Z6D7 A0A8C0Z6D7_CANLF ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) PIF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomere maintenance via telomerase [GO:0032211]; telomere maintenance [GO:0000723] mitochondrion [GO:0005739]; nucleus [GO:0005634] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; G-quadruplex DNA binding [GO:0051880]; hydrolase activity [GO:0016787]; telomerase inhibitor activity [GO:0010521] GPCAPGLV;ISMVEADLFDKLE 2 3 1.0038 -1.0406 0 0 0 0 8.55005 0 10.4565 0 0 0 0 0 0 0 0 A0A8C0Z6E1 A0A8C0Z6E1_CANLF RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) "3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]" AVSPPGPL;GHTLLYRLFQHYQREAH;GKARKFELD;LGFRAAHVMIKEYMIQ;PEDPEDTESDFWPSDTE;PVLLRKLRL;TEAILSFV;TELNADDSILQ;VGVLKRKRREL;VGVLKRKRRELV;VHIADVASSLP;VILCTCSCAASASL;VLQYCCLTQDRRAFRAPTRAELEQH;VLSTVHNHHSLL;VRIVLWRQR 15 6.9 1.0021 -2.5943 11.3542 0 10.3619 0 5.48617 10.1004 12.4189 0 9.4635 0 0 0 10.5508 9.80874 0 A0A8C0Z6E3 A0A8C0Z6E3_CANLF Tetratricopeptide repeat domain 21B TTC21B Canis lupus familiaris (Dog) (Canis familiaris) ARNQLKRIAKMNWNPIDA;LEMHQNYSGALEAV;LKRCLRHNKSCCK;MMTLIHYYCQE;YKITLAFSRTCGRSQLILQKIQ 5 5.9 0.98984 -0.22001 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5441 A0A8C0Z6F3 A0A8C0Z6F3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EGDQPLPGTLGSTGSSFD 1 8.6 0.95082 0.056896 0 0 0 0 0 0 0 0 0 0 0 8.38845 0 0 0 A0A8C0Z6H8 A0A8C0Z6H8_CANLF Transmembrane 9 superfamily member TM9SF3 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to membrane [GO:0072657] membrane [GO:0016020] DLYTERGSMLS;FFQHRIHWFSIFNSFMMVIFLV;FKEDVMPAT;IFAVSLIVIIV;PLPGAPGVAAAAALLLLV;RWQWTSFLSAASTAIYVYMYSFY 6 16 1.002 -1.2177 0 0 3.2306 8.00972 0 7.06996 0 0 18.9777 0 0 0 0 0 0 A0A8C0Z6L9 A0A8C0Z6L9_CANLF exo-alpha-sialidase (EC 3.2.1.18) NEU4 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] exo-alpha-sialidase activity [GO:0004308] ICRTSPHAFTF;SPLGSRVQ;YSDLASVGRTPKG 3 6.7 1.0023 -0.73854 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9341 0 A0A8C0Z6M1 A0A8C0Z6M1_CANLF Mediator of RNA polymerase II transcription subunit 13 MED13L Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] DEDSTSGNF;DLDNIFDNSDDDELG;EVSSSRKYDK;LIEEWQYFYPMVLK;NKSEHLSC;QVLVSPYGLNGT;SASVVGQN;SSNSRQTLPCV;VEDGLGSPKPE;VEVIVGESG;VEVIVGESGG;VGSLADPDYLN;VSSAGSAFNPT;WSSEENDNHSR 14 6.6 1.0028 -2.1636 12.4051 11.5803 9.62364 5.25897 11.5812 7.43054 11.0333 10.1957 0 12.3109 0 0 12.6674 0 12.0316 A0A8C0Z6N6 A0A8C0Z6N6_CANLF Aspartyl aminopeptidase (EC 3.4.11.21) DNPEP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] ASGEHRAKGSGQGQSGCL;VGFQQVGVETYGGGIWSTW 2 6.8 0.93439 0.099841 0 0 0 0 0 0 0 9.01809 0 0 0 0 0 11.9028 0 A0A8C0Z6P7 A0A8C0Z6P7_CANLF Palmitoyltransferase (EC 2.3.1.225) LOC609445 Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] protein-cysteine S-palmitoyltransferase activity [GO:0019706] LFPVKTKIPVVLGIGVLVLL;VKPKELLL 2 7 1.0033 -1.0562 0 0 7.73118 0 0 0 0 7.03353 0 0 0 0 4.47203 0 0 A0A8C0Z6U3 A0A8C0Z6U3_CANLF AAA+ ATPase domain-containing protein DNAH3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DEFNRIEVEVL;EEKLVRVQEILD;ETARMMVKIEEE;FQEWIDNGPPVVFWISGFY;FVVQVSELIIP;ITKNYSSYDWRE;NESDLRISMQQV;SEDNICDLNDFQW;TVSRCGMI;VPVTLHPSPAQSIPNAYLVLQI;VRHGYMIVGDP;VTPTSYLELILTFKTL 12 5.2 0.9515 0.049805 0 0 0 0 0 0 6.16501 0 0 0 0 0 0 0 0 A0A8C0Z6W3 A0A8C0Z6W3_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NAD+ ADP-ribosyltransferase activity [GO:0003950] ADASKLPNLNELLQSSG;LLLLLIFSQIHKQ;VGQTAPGS 3 5.6 1.0042 -1.0446 0 0 0 0 9.40897 0 0 0 0 0 0 0 0 0 4.01685 A0A8C0Z6Y1 A0A8C0Z6Y1_CANLF Anoctamin Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] AIYPMVLNWWRRRKARTNSEKLY;EDEGAGPGETVGPGE;GGGGGGGA;GGGGGGGG;GGRGGGGG;KPSEPPNPV;LFYEYLET;PAETFPFSYMLGP;SEDEGAGPGETVGPG;SEECDPGG 10 8.6 1.003 -1.9336 10.4737 0 0 9.96242 9.00149 0 0 0 0 8.05637 9.54919 0 10.8784 0 0 A0A8C0Z6Y3 A0A8C0Z6Y3_CANLF Solute carrier family 51 subunit alpha SLC51A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGKVEAWRLWW;GPCCCCCPCC;HTGPCCCCCPC;HYLSHCGRGEIGGGEKACLPH;LQLLMLGPFQYAF;LTIIMTLFTLGS;LWWGRRVWNRPRLWGFFH;MIHTGPCCCCCPC;PCCCCCPCCPP;TGPCCCCCPCCP;TGPCCCCCPCCPP 11 22.5 1.0038 -1.1034 9.97039 8.95228 0 8.20433 10.5961 8.68475 8.8587 0 0 0 4.3749 0 6.55424 0 0 A0A8C0Z6Y7 A0A8C0Z6Y7_CANLF FRAT regulator of WNT signaling pathway 2 Canis lupus familiaris (Dog) (Canis familiaris) QLVLSGNLIKEAVRRLQ 1 7.3 0.97906 0.046227 0 0 0 0 0 0 5.71872 0 0 0 0 0 0 0 0 A0A8C0Z717 A0A8C0Z717_CANLF Stress-activated protein kinase JNK (EC 2.7.11.24) MAPK10 Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310] DKQVDVSYIAKHYNM;KSKVDNQFYSVEVG;NVFTPQKTLEEFQDVYLVMELMDA;SEEKTKNGVV 4 13.5 1.0029 -1.3855 9.50718 0 0 0 9.36903 0 11.6299 0 0 0 0 0 0 8.87104 0 A0A8C0Z725 A0A8C0Z725_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PAK6 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GLPECLVP;LVGEELWVLMEFLQGG;VIMRDYQHLNVVEMYKSYLVGEELW 3 6.6 1.0031 -1.3367 0 0 0 0 0 10.8047 12.5409 0 0 0 0 0 0 0 0 A0A8C0Z733 A0A8C0Z733_CANLF Formin like 2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of cell morphogenesis [GO:0022604] actin binding [GO:0003779]; small GTPase binding [GO:0031267] ALERVEELEENISHLSE;LDSPQGDPRAHSAP;NSVSRSGRHSALRYNT;TESIQMLTPQLHSIIA;TKSTDRKQTLLHYIS 5 7.1 0.99639 -0.5768 0 11.4622 9.34463 0 0 11.1041 0 0 9.34565 0 0 0 7.53496 0 0 A0A8C0Z784 A0A8C0Z784_CANLF Radical S-adenosyl methionine domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) porphyrin-containing compound biosynthetic process [GO:0006779] mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; metal ion binding [GO:0046872]" EEAAVRSCLVTEAQT;ILLLDHRGL;PSFRRRGP 3 6 1.0038 -0.81219 0 0 0 0 0 0 9.27233 0 0 0 10.1665 0 0 0 0 A0A8C0Z790 A0A8C0Z790_CANLF Transferrin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] AEDPGACVMGSPSRLR;ALLCRDGSRADVT;DAAGDGVC;DNTNGHNS;FSRQRLKPEIQCV;FVKHSTVL;TEWRRCHLARVPAH;VLENTDGRTL;YLRWCVLSTPE 9 10.5 1.0031 -1.943 7.5803 0 0 9.90369 0 7.3137 8.82359 4.98796 0 0 0 0 0 5.93317 8.45968 A0A8C0Z795 A0A8C0Z795_CANLF Metal transporter CNNM1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular manganese ion homeostasis [GO:0030026]; magnesium ion homeostasis [GO:0010960] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] CSDNDVRKVGS;FFSLSPQPPAAA;LRVLRNSG;LSEKILLRLLKH;VSGGVRSQFPPE;YNRPLHCVFNDT 6 6.6 1.0028 -0.77318 12.6296 9.53031 0 0 5.75881 0 12.7484 0 0 3.29471 9.76168 6.55468 0 0 0 A0A8C0Z798 A0A8C0Z798_CANLF Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; nervous system development [GO:0007399]; platelet aggregation [GO:0070527] plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] AALALILLRKRR;DLAARNCMLAEDMTVCVADFGL;DPKQRPSFTCLRMELE;KEFDHPHVAKLVGV;REAQLKQEDGSF;SNASVAWMPG;VGATPSDYRYI;VYIPVSEQHWIG 8 13.8 1.0025 -1.1461 9.97499 10.0661 6.87713 0 0 0 0 6.79896 0 0 8.01998 0 9.48123 0 0 A0A8C0Z7B8 A0A8C0Z7B8_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] histone binding [GO:0042393] EDEEDEEEEEEGEEEDVSGEE;VEDEEDEEEEEEGEEEDVSGE;VGKREEEYDEDAQVVEDE 3 13.7 0.97151 0.048313 0 8.40062 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z7C5 A0A8C0Z7C5_CANLF VWFA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] calcium channel activity [GO:0005262] DTEYPVFV;SEDMEAML 2 1.5 0.98944 -0.21651 0 0 0 0 0 0 0 9.10376 0 0 0 0 0 0 0 A0A8C0Z7C8 A0A8C0Z7C8_CANLF Sema domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MICOS complex [GO:0061617]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] DRGSKMVSEIYL;GSGKPHNG;IHCRSPSARE;KKHFLLTFIRTLEAQ;LLLPLLLLL;LLLPLLLLLL;LLLPLLLLLLLRGAQGAAGAPR;LLPPPPPLLLLPLLLLLLLRGA;LPPPPPLLLLPLLLLLLLR;LVKNHDHLDQREGDRGS;NSCLVYNDTTMV;PLLLLPLLLL;PLLLLPLLLLL;PLLLLPLLLLLLL;RESCGLCLKADP;VLLPPPPPLLLLPLLLLLL;VLLPPPPPLLLLPLLLLLLL;VLLPPPPPLLLLPLLLLLLLRGA;VSVGGRPCS;YVYSFRSEQFVYYLTLQ 20 6.7 0.98984 -0.26592 0 12.1068 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8C0Z7E8 A0A8C0Z7E8_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KSIITRAKL;PLSSLSERRPMLAS 2 4.6 0.98301 -0.25577 0 0 0 0 0 0 0 0 9.22641 0 0 0 0 0 0 A0A8C0Z7E9 A0A8C0Z7E9_CANLF mitogen-activated protein kinase kinase (EC 2.7.12.2) MAP2K5 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] CMRKQPKERPAPEDLMGHPF;EDEDGDRITVRSDE;PKERPAPEDLM;YHVPSGKILAVKVILL 4 11.7 0.99435 -0.1223 0 0 0 0 0 0 0 0 9.34689 0 7.83295 0 0 9.6418 5.27702 A0A8C0Z7G1 A0A8C0Z7G1_CANLF Integral membrane protein GPR175 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DTPEEVVWA;HRCLLLLYEDI;PHRCLLLLYEDIGTSRVR;PHSPGTPHVGAVTPPGLA 4 10.6 0.99744 -0.1026 7.22997 0 0 0 0 0 0 0 0 9.84127 0 0 12.3233 0 0 A0A8C0Z7G3 A0A8C0Z7G3_CANLF Myosin tail domain-containing protein CGNL1 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] ERCLAGTSFPENGP;TSVCVNVQSCTGEALVGEA;VLEESSAEELQL;VLNNTERCLAGTS 4 4.1 0.98851 -0.34346 0 0 9.52005 0 11.5384 0 11.6784 7.2556 0 10.7973 0 11.205 0 10.5595 10.654 A0A8C0Z7H4 A0A8C0Z7H4_CANLF Heat shock protein 105 kDa (Heat shock 110 kDa protein) HSPH1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] SEENKIPDADKANEKK 1 2 0.98338 -0.25365 0 0 0 0 0 9.12322 0 0 0 0 0 0 0 0 0 A0A8C0Z7I9 A0A8C0Z7I9_CANLF Disintegrin and metalloproteinase domain-containing protein 10 (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) ADAM10 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] clathrin-coated vesicle [GO:0030136]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; SH3 domain binding [GO:0017124] CDCGYSDQCKDECCYDANQP;CGYSDQCKDECCYDANQ;DCGYSDQCKDECCYDAN;EQGEECDCGYSDQC;EQGEECDCGYSDQCKDECCYD;GEECDCGYSDQCKDECCYDA;GEECDCGYSDQCKDECCYDAN;LGGQYGNP;QCKDECCYDANQPEGK;VEQGEECDCGYSDQCKDEC;VIYHEDDI 11 6.3 1.0035 -1.5711 9.30823 0 0 0 0 0 0 7.04887 0 0 4.36576 9.73574 6.23216 6.36298 6.40633 A0A8C0Z7J3 A0A8C0Z7J3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) MINDY2 Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cell periphery [GO:0071944]; cytosol [GO:0005829] cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; histone deubiquitinase activity [GO:0140934]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435] EIQRLNYEQ;PSDPETVY;QEEEDRRASQYYQEQEQAAAA;VNVKFTGVRVF 4 8.9 1.0023 -0.65923 10.4638 0 0 0 0 0 0 0 12.3717 0 0 0 0 10.5118 0 A0A8C0Z7K3 A0A8C0Z7K3_CANLF Myosin IE MYO1E Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; vesicle transport along actin filament [GO:0030050] cytoplasm [GO:0005737]; myosin complex [GO:0016459]; vesicle [GO:0031982] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146] AEQEEYVQEGIRW;ETKKPRDWEESRVKHQVE;FKQMPYFGEKE;IVCDLIENKINP;LHARVFDFL;NYAAVESEEFLAFP;PPGHHQNGVIKNQ;SLFPENLQ 8 9.2 0.98961 -0.52644 10.2395 0 10.1658 0 0 0 9.83134 6.00906 0 0 0 10.4993 4.92286 0 0 A0A8D4WCF2 A0A8D4WCF2_CANLF DLA class II antigen Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] ESWNRQKELLERKRAE;GVIESFAVQRRVEPTVT;NREEHVRFDSDVGEYRAVTEL;VGEYRAVT 4 20.4 1.0032 -1.5223 0 0 0 0 0 8.86728 0 0 0 0 0 0 10.6472 5.28629 0 A0A8I3M830 A0A8I3M830_CANLF U1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) precatalytic spliceosome [GO:0071011] double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] KHQKVFLLLLLLVFN 1 5.2 0.95119 0.053874 0 0 0 0 0 0 0 0 0 0 0 5.81514 0 0 6.74658 A0A8I3M8K6 A0A8I3M8K6_CANLF SMB domain-containing protein ENPP1 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] DTFQTPSQCD;EDLAKNLSCREPNQHFKP;FSNMQALF;IDNKIYDP;KNTTVCLLYQHQFVSGYS 5 7.4 1.0022 -1.8606 0 0 8.05994 7.58173 0 0 0 0 0 0 0 0 0 0 0 A0A8I3M9M5 A0A8I3M9M5_CANLF Coiled-coil domain containing 170 CCDC170 Canis lupus familiaris (Dog) (Canis familiaris) DAIVERIREM;EQLGNESGFHQ;ESAALTASKIRTEITAH;HLEGELVSGD;QTKEIYDHLLEVP 5 9.5 0.99766 -0.5991 0 10.6924 13.6458 0 0 0 13.9971 14.0389 0 13.8534 0 13.5499 0 0 0 A0A8I3M9Q3 A0A8I3M9Q3_CANLF TNF receptor superfamily member 11a TNFRSF11A Canis lupus familiaris (Dog) (Canis familiaris) EHFGRCCNKCE 1 4.2 0.98137 0.035491 0 0 0 0 0 0 0 0 0 0 8.4605 0 0 0 0 A0A8I3M9R5 A0A8I3M9R5_CANLF Zinc finger AN1-type containing 5 ZFAND5 Canis lupus familiaris (Dog) (Canis familiaris) face development [GO:0060324]; fibroblast migration [GO:0010761]; in utero embryonic development [GO:0001701]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculature development [GO:0001944] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AGSTSEKSRNVP 1 5.6 0.94381 0.05044 0 0 0 0 0 0 0 0 0 0 0 9.10899 0 0 0 A0A8I3M9S1 A0A8I3M9S1_CANLF RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) CTDP1 Canis lupus familiaris (Dog) (Canis familiaris) exit from mitosis [GO:0010458]; positive regulation by host of viral transcription [GO:0043923] centrosome [GO:0005813]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096] AGESLDQSVEEEEDDEDDGDEDDHL;EDDGDEDD;EEEDDEDDGDEDDH;EQHCQQMSNKGIFHF;ESLDQSVEEEEDDEDDGDE;GARDAGKAAQRGGPSGPGGE;PQRKIHEITWEQVWWWKFRRHSWLY;TAGESLDQSVEEEEDDEDDG 8 8.7 0.97923 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 4.56328 0 0 A0A8I3M9U4 A0A8I3M9U4_CANLF Hes related family bHLH transcription factor with YRPW motif 2 HEY2 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior axis specification [GO:0009948]; aortic valve morphogenesis [GO:0003180]; arterial endothelial cell differentiation [GO:0060842]; ascending aorta morphogenesis [GO:0035910]; atrial septum morphogenesis [GO:0060413]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell apoptotic process [GO:0010659]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac vascular smooth muscle cell development [GO:0060948]; cell fate commitment [GO:0045165]; cochlea development [GO:0090102]; coronary vasculature morphogenesis [GO:0060977]; dorsal aorta morphogenesis [GO:0035912]; endocardial cushion to mesenchymal transition involved in heart valve formation [GO:0003199]; heart trabecula formation [GO:0060347]; labyrinthine layer blood vessel development [GO:0060716]; mesenchymal cell development [GO:0014031]; muscular septum morphogenesis [GO:0003150]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of smooth muscle cell differentiation [GO:0051151]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of heart rate [GO:0010460]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex assembly [GO:0065004]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of inner ear auditory receptor cell differentiation [GO:0045607]; regulation of vasculogenesis [GO:2001212]; tricuspid valve formation [GO:0003195]; umbilical cord morphogenesis [GO:0036304]; vasculogenesis [GO:0001570]; ventricular cardiac muscle cell development [GO:0055015]; ventricular trabecula myocardium morphogenesis [GO:0003222] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" NSPTTTSQ;PLAVAAAAGPQP 2 6.4 1.0041 -1.1044 0 0 0 6.88923 0 0 0 0 0 0 0 0 0 0 0 A0A8I3M9V6 A0A8I3M9V6_CANLF G-protein coupled receptors family 1 profile domain-containing protein OR6Z2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GIRNALFAVF;PFTACIIQLFLF 2 6.8 0.98916 -0.21895 0 0 4.48491 0 0 0 0 0 0 0 0 10.0181 0 0 0 A0A8I3M9Z1 A0A8I3M9Z1_CANLF Large ribosomal subunit protein eL29 (60S ribosomal protein L29) LOC102153530 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LFVQINLRQDLLKKKRI;PAPASTPASTSVAQAPKGAHA 2 16.3 0.9339 0.099193 0 8.8888 0 0 0 0 0 0 9.20943 0 0 0 0 0 0 A0A8I3MA00 A0A8I3MA00_CANLF TEA domain transcription factor 2 TEAD2 Canis lupus familiaris (Dog) (Canis familiaris) hippo signaling [GO:0035329] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ASELFQFWSGGSGP;ATMSSAQLISAPSLQAKL;CPSPGAPPLESVDV;SKDKAFQTMATMSSAQLISAP 4 12.3 0.98737 -0.37013 9.04781 0 0 0 0 6.97246 0 0 0 0 11.1932 0 0 0 0 A0A8I3MA02 A0A8I3MA02_CANLF X-ray repair cross complementing 1 XRCC1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; double-strand break repair via nonhomologous end joining [GO:0006303]; single strand break repair [GO:0000012] nucleus [GO:0005634] damaged DNA binding [GO:0003684] QGENGEDP;SKDSPYGLSFI;VLGLGGRIVRKEWVL 3 5.7 1.002 -1.2427 0 7.80297 5.8033 0 0 0 0 0 0 0 0 0 8.38716 0 0 A0A8I3MA08 A0A8I3MA08_CANLF Peptidase D PEPD Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; peptidase activity [GO:0008233] IQDGDMCLFDMGGEYYC;VGMKEYEMESLFEHYCYSRGGMRHS;VTDSGMELL 3 11.9 1.0029 -0.72245 0 0 0 0 0 0 0 6.67638 0 0 0 7.31207 7.60866 0 8.8117 A0A8I3MA21 A0A8I3MA21_CANLF Lysine-specific histone demethylase (EC 1.14.99.66) KDM1A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] chromatin binding [GO:0003682]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660] EEENESEPEEPSGQAGG;GIYKRIKPLPTKKTGKVIII;GPTVVPGSATPMETGI;KKEPPRASPPGGLAEP;PKEKDEMVEQEFNRL;SEDEYYSEE;TQKVFLFIRNRTLQLWL 7 12.6 0.98826 -0.37491 7.09624 6.42359 0 8.15325 0 0 8.85723 6.08572 6.72574 11.1034 0 0 0 0 0 A0A8I3MA41 A0A8I3MA41_CANLF Zinc finger protein 575 ZNF575 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RLAHGGARPHPCPD 1 5.7 0.94133 0.061037 0 0 0 0 0 0 0 0 0 0 0 0 0 8.92235 0 A0A8I3MA52 A0A8I3MA52_CANLF Zinc finger protein 667 ZNF667 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GYKERGRTLHHDSTTFQH;VISFLEQGKEPWMVEKAA;YGLECSRFQDDWECISQ 3 10.3 0.99234 -0.039756 4.48684 0 0 0 0 0 11.6612 0 0 0 0 0 0 0 0 A0A8I3MA56 A0A8I3MA56_CANLF Transient receptor potential cation channel subfamily M member 4 TRPM4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] LKQLRQIREYEQRL;SLYANWLVVLLLIIFLLV;VEDAFGAAMVTVW;VLLLIIFLLVANILLLNL;VLLLIIFLLVANILLLNLLI;YFWEMGSNAVASA 6 6.4 0.99353 -0.057689 0 0 0 0 8.60006 0 8.43112 6.7416 7.13822 0 0 0 0 0 0 A0A8I3MA68 A0A8I3MA68_CANLF E2 NEDD8-conjugating enzyme (EC 2.3.2.34) UBE2M Canis lupus familiaris (Dog) (Canis familiaris) protein neddylation [GO:0045116] ATP binding [GO:0005524]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842] LVICPDEGFY 1 5.5 0.99884 -0.61146 0 7.87879 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MAA1 A0A8I3MAA1_CANLF Tripartite motif containing 28 TRIM28 Canis lupus familiaris (Dog) (Canis familiaris) transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] GDTKFSAV;PPRAPGPLSKQG 2 2.7 0.98713 -0.45953 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.33273 A0A8I3MAC5 A0A8I3MAC5_CANLF Zinc finger protein 444 ZNF444 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IQAWVCSRQPQSGEEAV 1 5.2 0.98416 0.046227 0 0 0 8.03441 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MAC7 A0A8I3MAC7_CANLF "Transmembrane protein 129, E3 ubiquitin ligase" TMEM129 Canis lupus familiaris (Dog) (Canis familiaris) "protein polyubiquitination [GO:0000209]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ubiquitin protein ligase activity [GO:0061630] DTWVMKVTTYRV;FASLVEVNPTYSVP;QELEACIGC 3 9.7 1.0018 -0.69269 10.6711 0 0 0 0 0 0 0 0 8.01787 9.55094 0 0 0 0 A0A8I3MAD7 A0A8I3MAD7_CANLF Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled dopamine receptor signaling pathway [GO:0007212] heterotrimeric G-protein complex [GO:0005834] corticotropin-releasing hormone receptor 1 binding [GO:0051430]; G protein-coupled serotonin receptor binding [GO:0031821]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mu-type opioid receptor binding [GO:0031852] APHPTLRRLRLRLRLRLLPQ;ERKKWIHCFEDVTAIIFCVALSGY;EYGDKERK;GEPCQPSRAGCGREGA;LRRLRLRLRLRLL;PAPHPTLRRLRLRLRLRLL;RLRLRLRLRLLPQLLFY;RLRLRLRLRLLPQLLFYL;TLRRLRLRLRLRLLPQLL;TLRRLRLRLRLRLLPQLLFYLFWV 10 10 1.0036 -1.0665 0 5.11774 0 12.9238 0 0 0 19.9536 0 0 3.03143 0 5.29825 3.86394 0 A0A8I3MAI4 A0A8I3MAI4_CANLF Zinc finger protein 787 ZNF787 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YYRAGAGGEDDKDDDD 1 4.2 0.96126 0.049233 0 0 3.86977 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MAI7 A0A8I3MAI7_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A5 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] AAPDDGGDGDEETDDETDG;DGGDGDEETDDETDGEDGE;EDVFQESYVPAWQDE;GEAGLLLTQVLRHQPFLGYRGAREL;PGHTGAAH;QGPRLTSPHPPHPVQMAAAEAV 6 10.3 0.97595 0.035538 0 0 0 0 3.71655 0 0 0 0 0 0 0 0 0 0 A0A8I3MAJ6 A0A8I3MAJ6_CANLF Long-chain-fatty-acid--CoA ligase SLC27A5 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] AAPDDGGDGDEETDDETDG;DGGDGDEETDDETDGEDGE;DHLLLRWNRLPKALRSV;EDVFQESYVPAWQDE;PGHTGAAH;PVLSLSDHCLGPSVSHLLS;QGPRLTSPHPPHPVQMAAAEAV 7 12.9 0.98974 -0.21434 0 7.31606 0 4.61406 0 0 0 0 11.5218 0 0 12.5094 12.8344 12.8151 5.64987 A0A8I3MAJ8 A0A8I3MAJ8_CANLF Required for meiotic nuclear division 1 homolog RMND1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of mitochondrial translation [GO:0070131] mitochondrion [GO:0005739] ASLDKFVESIQSI;EIQPYEIALVHWENEELTYIKTEGQ;ERKRSRRRGSR;LVHWENEELTYIKTEGQSRL;RKLARFPPRHVPLLFRR;VILITIEVMFE 6 13.4 0.98964 -0.52175 6.01257 0 0 0 0 9.14845 11.5565 0 12.8357 0 0 9.37797 0 0 0 A0A8I3MAK4 A0A8I3MAK4_CANLF Hsp70-interacting protein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983] DEPSDDESDL 1 6.2 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.74187 A0A8I3MAL0 A0A8I3MAL0_CANLF PTPRF interacting protein alpha 3 PPFIA3 Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] cytoplasm [GO:0005737]; presynaptic active zone [GO:0048786] ELQRARQREKMNDD;ESLYRQSEEKSRQLA;GRLFGKKEKGRMGPP;IKSSIGRLFGKKEK;LPEIEAQLAQRV;LPFAAWDGP;LSPSGQADVQT;QIPTQNAQARQLLEKEFSN;VMVWSNERVMGW 9 9.5 1.0049 -1.0505 0 0 0 0 8.40905 13.044 0 11.7328 0 10.2259 0 0 0 0 0 A0A8I3MAM9 A0A8I3MAM9_CANLF TIAM Rac1 associated GEF 2 TIAM2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EEAGEEAGEAGEAGEAGEAGEAGE;EGRGSPRVLIKTLGRL;ELLHIYGSTANGVPRDNTWEAQ;ESKTNIVKVI;NVETSTDTADSSSGS;PAGAPAAP;SSLEQLDLLFEK;TVLCRSFNDTQSNG 8 7.2 1.002 -1.2305 0 10.152 0 8.10245 8.73407 0 0 0 6.2989 0 6.91564 10.9529 7.73911 5.15457 0 A0A8I3MAR5 A0A8I3MAR5_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A5 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] GEAGLLLTQVLRHQPFLGYRGAREL;LVLDSQTIPA;QPGHAPLVWKGPGSRSFTFRELDD 3 8.1 1.0024 -0.89754 0 0 0 10.0323 0 0 0 9.90462 0 0 0 0 0 0 0 A0A8I3MAS2 A0A8I3MAS2_CANLF Uncharacterized protein NLRP9 Canis lupus familiaris (Dog) (Canis familiaris) KGEDLEIVSESTTSL;LVCTCMKWQ;LVCWLVCTCMKWQLEKGEDLEIVS;STEKITNLLETSFGF 4 4.6 0.99449 -0.17372 0 0 10.103 0 8.80213 8.38737 0 0 0 0 0 0 0 0 0 A0A8I3MAS6 A0A8I3MAS6_CANLF Small nuclear ribonucleoprotein U1 subunit 70 SNRNP70 Canis lupus familiaris (Dog) (Canis familiaris) RVWATKAETCTW 1 5.6 0.95422 0.05044 0 0 0 0 6.40132 0 0 0 0 0 0 0 0 0 0 A0A8I3MAV2 A0A8I3MAV2_CANLF "Lectin, mannose binding 1" LMAN1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; positive regulation of organelle organization [GO:0010638] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; sarcomere [GO:0030017] FEYKYSFKGPHLVQSDGTVPFWAHA;ILDEQRRYVSSLTEEI;PGSAGGVY;VLSFLTFQLTEP 4 11.8 0.98781 -0.48769 0 0 0 0 0 0 8.66035 7.93298 9.62068 0 0 0 9.71397 6.78385 0 A0A8I3MAV7 A0A8I3MAV7_CANLF Pentatricopeptide repeat domain 2 PTCD2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA processing [GO:0050684] mitochondrion [GO:0005739] AFAICYKLNS;EVLIEMKNQDVKFNKDTYV 2 13.4 0.99418 -0.56161 0 0 0 0 12.0175 0 0 7.03111 0 0 0 0 0 0 0 A0A8I3MAV8 A0A8I3MAV8_CANLF Coiled-coil domain containing 106 CCDC106 Canis lupus familiaris (Dog) (Canis familiaris) LTTPIAELLI 1 4.1 0.99862 -0.61146 0 0 0 0 0 7.35067 0 0 0 0 0 0 0 0 0 A0A8I3MAW0 A0A8I3MAW0_CANLF Zinc finger protein 132 ZNF132 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SPVTFEDVAV 1 1.4 0.99884 -0.61146 0 0 0 0 0 0 0 0 9.85141 0 0 0 0 0 0 A0A8I3MAW3 A0A8I3MAW3_CANLF Integrin subunit alpha 1 ITGA1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] cell surface [GO:0009986]; integrin complex [GO:0008305] metal ion binding [GO:0046872] DENIQRFSIAILGSYNRGN;DIDKDSNTDILLVGAP;ESECTKLSFYM;GGFLACGP;LLILALWKIGFFKRP;VLGFCVSFNVDVKNSMTFSG 6 7.5 0.99308 -0.16024 6.3326 0 9.12603 5.04404 0 0 6.74712 0 12.1691 9.82596 0 0 0 0 0 A0A8I3MAZ6 A0A8I3MAZ6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SEESARISLSLFIL 1 11.4 0.93757 0.063384 0 0 0 0 0 0 9.61692 0 0 0 0 0 0 0 0 A0A8I3MB33 A0A8I3MB33_CANLF Protein pelota homolog ITGA1 Canis lupus familiaris (Dog) (Canis familiaris) "nonfunctional rRNA decay [GO:0070651]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; ribosome disassembly [GO:0032790]; RNA surveillance [GO:0071025]" cytoplasm [GO:0005737] metal ion binding [GO:0046872] GEQLSQLTGVAAILRFPVP 1 4.9 0.95427 0.049463 0 0 0 0 0 0 0 0 0 5.14282 0 0 0 0 0 A0A8I3MB38 A0A8I3MB38_CANLF Uncharacterized protein LARP4B Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AADGGVSADWEESSGPCTDC;EFAYNDNWFITFETEADA;GGVSADWEESSGPCTDCGQ;GTPVLHLDAGSAADGGV;GVLPKRGG;IAVPPCGD;IAVPPCGDHVL;RDRDVREAALVPS;RQTGQPRT 9 5.4 1.0025 -1.7686 0 7.39343 10.9447 7.79883 0 0 11.4857 9.0698 0 10.7732 0 0 11.1494 0 9.3856 A0A8I3MB73 A0A8I3MB73_CANLF Uncharacterized protein PAIP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of translational initiation [GO:0045947] cytoplasm [GO:0005737] mRNA regulatory element binding translation repressor activity [GO:0000900] ELWEEEFIERCFQEMLEEEEEHEWF;LPQTMDQIQDQFNDLVINDGS;LVVKLFFILL;YMWMENEEEFNRQIEEELWEEEFIE 4 46.2 0.988 -0.49216 0 0 5.05974 0 0 0 8.83845 0 0 0 0 0 0 0 7.41574 A0A8I3MB88 A0A8I3MB88_CANLF Hydroxysteroid 17-beta dehydrogenase 14 NTN5 Canis lupus familiaris (Dog) (Canis familiaris) steroid catabolic process [GO:0006706] cytosol [GO:0005829] estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] NGAQVVICDKDES 1 4.8 0.99103 -0.22163 0 0 0 0 0 0 0 0 0 0 0 0 0 14.9187 0 A0A8I3MBA4 A0A8I3MBA4_CANLF Zinc finger protein 428 ZNF428 Canis lupus familiaris (Dog) (Canis familiaris) EEEDEEEEEEEATDDPE;EEEEDEEEEEEEATDDPEYDP;LSEPDSEEEEDEEEEEEEATDD;VGEGRPAGREEEEEEEEEEGTYHCT 4 27.1 0.99216 -0.14149 7.51531 0 5.78089 0 6.64775 5.65191 0 0 0 0 0 0 0 0 0 A0A8I3MBB6 A0A8I3MBB6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AASADITTSIA;AGTSTASPDMSTSTGS;ATSPDATTSASPDMTTSTVSPD;ATTSASPDMTTSTAR;GTTSAAATD;MTTSTAWPD;PEAITSTASPDV;STSTVSPDRTTSSSAQDET;TVSPDMSTSTMSPDMST;TVSPDRTTS;VTISPALPEASTSI 11 7.3 0.98973 -0.53075 0 0 0 0 0 0 12.2231 0 0 0 0 0 0 0 0 A0A8I3MBF5 A0A8I3MBF5_CANLF RuvB-like helicase (EC 3.6.4.12) RUVBL2 Canis lupus familiaris (Dog) (Canis familiaris) box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; DNA helicase activity [GO:0003678]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714] LDDALEPRQA;TTEMETIYDLGTKMIESLTKD;VRIKEETEIIEGE 3 9.5 0.99332 -0.13263 0 0 10.0369 0 0 0 0 8.75094 0 0 0 0 9.42192 0 0 A0A8I3MBI2 A0A8I3MBI2_CANLF NFKB inhibitor delta NFKBID Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DIREHKGKTP;DPHRCLLWPPDHPWTQPVL 2 8.4 0.99411 -0.56191 0 0 0 0 0 9.80487 0 5.05237 0 0 0 0 0 0 0 A0A8I3MBI7 A0A8I3MBI7_CANLF Cilia and flagella associated protein 95 CFAP95 Canis lupus familiaris (Dog) (Canis familiaris) LANIKKKA 1 5 1.0044 -1.1044 0 0 7.62007 0 0 0 8.13499 0 0 0 0 0 0 0 0 A0A8I3MBJ4 A0A8I3MBJ4_CANLF BTB/POZ domain-containing protein KCTD7 KCTD7 Canis lupus familiaris (Dog) (Canis familiaris) membrane hyperpolarization [GO:0060081]; protein homooligomerization [GO:0051260] cytosol [GO:0005829]; plasma membrane [GO:0005886] AGHALPLL;VYKEAQYYAIGP 2 10.8 1.003 -1.338 0 9.03505 0 0 0 7.43271 0 9.63822 0 0 0 0 0 0 0 A0A8I3MBK8 A0A8I3MBK8_CANLF Protein ARV ARV1 Canis lupus familiaris (Dog) (Canis familiaris) bile acid metabolic process [GO:0008206]; cholesterol transport [GO:0030301]; intracellular sterol transport [GO:0032366]; regulation of cholesterol metabolic process [GO:0090181]; regulation of intracellular cholesterol transport [GO:0032383]; regulation of plasma membrane sterol distribution [GO:0097036]; sterol metabolic process [GO:0016125] endoplasmic reticulum membrane [GO:0005789] LLLKALLLSSYGKLLLIPAVI;TAKKKPNFTLLLKALLL;TLLLKALLL;TPLCLRLIK 4 13.9 1.0032 -1.515 0 0 0 0 0 5.53531 0 5.02046 0 0 0 0 0 5.38052 8.83378 A0A8I3MBL3 A0A8I3MBL3_CANLF Claudin CLDN20 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] FVSGMIFC 1 3.7 1.0034 -1.1044 0 0 8.64227 0 0 0 0 0 0 0 0 0 8.61563 0 0 A0A8I3MBN3 A0A8I3MBN3_CANLF Cytosol aminopeptidase (EC 3.4.11.1) (EC 3.4.11.5) (EC 3.4.13.23) (Cysteinylglycine-S-conjugate dipeptidase) (Leucine aminopeptidase 3) (Leucyl aminopeptidase) (Proline aminopeptidase) (Prolyl aminopeptidase) LAP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006] QENWHEGKENIRV;VGLGKKAAGVDDQENW;WNKLFEASIETGDRVWRM 3 8.3 0.84873 0.15716 10.552 0 0 0 0 0 0 0 9.74913 0 0 0 6.89857 0 0 A0A8I3MBP3 A0A8I3MBP3_CANLF Tetratricopeptide repeat domain 13 TTC13 Canis lupus familiaris (Dog) (Canis familiaris) AGCCCCYC;AGCCCCYCCW;AGCCCCYCCWG;CCCCYCCW;CCCCYCCWGG;CCCCYCCWGGA;CCCCYCCWGGAVAA;CCCYCCWGGA;CCCYCCWGGAVAAAD;ELICVADRLGSLM;GCCCCYCCWG 11 3.8 1.0032 -2.2602 6.09852 0 3.179 5.41724 0 4.81008 0 0 7.00742 0 5.15753 0 0 6.2549 0 A0A8I3MBS0 A0A8I3MBS0_CANLF Zinc finger protein 580 ZNF580 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hydrogen peroxide [GO:0070301]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte chemotaxis [GO:0002690] nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEPRGPPQ 1 4.7 1.0047 -1.1044 0 9.01237 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MBX9 A0A8I3MBX9_CANLF Matrix metallopeptidase 12 MMP12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] FPTYSYVNPNTFHLS;PFDGRGGVIAHAFGP 2 6.4 0.98204 -0.24868 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.821 A0A8I3MC04 A0A8I3MC04_CANLF Galanin receptor 1 GALR1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944] plasma membrane [GO:0005886] galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046] GHKKAYVVCTFV;SFLFRIAAHCLAYSN 2 7.7 0.99353 -0.023108 0 0 0 14.3175 0 0 0 0 0 0 0 0 0 0 9.8462 A0A8I3MC10 A0A8I3MC10_CANLF O-acyltransferase like OACYL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" ALHRTLWAAGVGWI;DTFFLISG;IFMHQNHQAN;LKRYLLGPLPAGP;RALTCFSWQKNML;SEASENATVLYFS;TDTNMFYLFFGHC;TWYLANDFQFHL 8 15.1 1.0032 -1.3827 0 0 6.8936 0 0 8.40263 9.24232 0 9.3388 0 0 0 0 0 8.4696 A0A8I3MC17 A0A8I3MC17_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM56 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein monoubiquitination [GO:0006513] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] PRGGRSNKKRKFKG;TNFFVNGLLDLV 2 3.4 0.99293 -0.16962 0 0 4.58514 0 0 0 0 10.5911 0 0 0 0 0 0 0 A0A8I3MC22 A0A8I3MC22_CANLF Integrin subunit alpha 2 ITGA2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion mediated by integrin [GO:0033627]; integrin-mediated signaling pathway [GO:0007229]; mesodermal cell differentiation [GO:0048333]; substrate-dependent cell migration [GO:0006929] basal part of cell [GO:0045178]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; integrin alpha2-beta1 complex [GO:0034666] amyloid-beta binding [GO:0001540]; collagen binding involved in cell-matrix adhesion [GO:0098639]; collagen receptor activity [GO:0038064]; metal ion binding [GO:0046872] GVIIGSVIAGIILLLALVAVLWK;KAVIDQCNNDNIL;RHIKDLNCRTASCS;SCAEYTINIQKPSDV;VGSPLENQNSGAVY;YSVAAIST 6 7.4 0.99043 -0.29823 0 8.75288 0 0 0 0 0 8.89385 4.78649 0 0 8.02813 0 6.12761 0 A0A8I3MC53 A0A8I3MC53_CANLF TIAM Rac1 associated GEF 2 TIAM2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EDTGQMLGSAEQI;ELLHIYGSTANGVPRDNTWEAQ;ESKTNIVKVI;TVLCRSFNDTQSNG 4 5.7 0.9387 0.059747 0 0 11.2772 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MC64 A0A8I3MC64_CANLF ETS2 repressor factor ERF Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]" FSPEDMKRYLQ;HYPGLVVP 2 3.4 1.0027 -1.4031 0 0 5.28288 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MC85 A0A8I3MC85_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HVRRQEKPSAGS 1 6.5 0.9913 -0.26982 0 0 0 0 0 7.3766 0 0 0 0 0 10.4273 0 0 0 A0A8I3MC96 A0A8I3MC96_CANLF F-box and leucine rich repeat protein 17 FBXL17 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] AAAGGDAGRAGGAAPSAAQQQQQ;ISDEGMIVIAKG;PENPCDCHRDPP;SHSLSPSLYVQTCT 4 9 0.94771 0.080139 0 0 0 0 9.41673 0 0 0 0 0 0 0 10.4444 0 0 A0A8I3MCB7 A0A8I3MCB7_CANLF F-box and leucine rich repeat protein 17 FBXL17 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] ISDEGMIVIAKG;PENPCDCHRDPP;RPGAPAAAGGDAGR 3 8.3 0.9889 -0.26134 0 0 0 0 0 0 0 12.2154 0 0 0 0 0 0 0 A0A8I3MCD6 A0A8I3MCD6_CANLF Globin domain-containing protein HBQ1 Canis lupus familiaris (Dog) (Canis familiaris) hemoglobin complex [GO:0005833] heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ADALTTAVAHLD;AHGKKVADALTTAVAHLD;ALSALSDLHA;ALSALSDLHAYKL;ALTTAVAH;ALTTAVAHL;ALTTAVAHLD;ALTTAVAHLDDLPG;ALTTAVAHLDDLPGAL;AVAHLDDLPGAL;DALTTAVAHL;DALTTAVAHLD;DKFFTAVSTVLTSKY;DKFFTAVSTVLTSKYR;DLPGALSALSDLHAYKL;DLPGALSALSDLHAYKLRVD;DPVNFKLL;FDLSPGSAQV;FFTAVSTVLTSKY;FPHFDLSPG;FPHFDLSPGSA;FPHFDLSPGSAQV;FPTTKTYFPHFD;FPTTKTYFPHFDLSPGSAQV;FTAVSTVLTSKY;FTAVSTVLTSKYR;HFDLSPGSA;HFDLSPGSAQV;KKVADALTT;LPGALSALSDLHAYKLRVD;LTTAVAHLD;PHFDLSPGSAQV;PPPHPPPQLTGPS;PTTKTYFPHFDLSPGSAQV;PVNFKLLSH;RTFQSFPTT;RTFQSFPTTKTYFPHFDLSPGSAQV;SALSDLHA;SALSDLHAYKLRVD;SDLHAYKLRVD;SFPTTKTYFPHFDLSPG;SFPTTKTYFPHFDLSPGSAQV;SLDKFFTAV;SLDKFFTAVST;SRRTFQSFPTT;TAVSTVLTSKY;TAVSTVLTSKYR;TFQSFPTTKTYFPHFD;TPAVHASLDKFFTAVSTVLTSKYR;TTAVAHLD;TTAVAHLDDLPG;TTKTYFPHFDLSPGSAQV;TYFPHFDL;TYFPHFDLSPG;TYFPHFDLSPGSAQV;VAHLDDLPGAL;VDPVNFKLL;VSTVLTSKY;VSTVLTSKYR;YFPHFDLSPGSAQV 60 54.4 0.98451 -0.24181 0 0 0 0 0 0 0 0 0 0 0 0 0 8.46287 0 A0A8I3MCF0 A0A8I3MCF0_CANLF Complement C1q C chain C1QC Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] TVTRQTAQYPLANNL;VPGPVGPP 2 9.8 1.0018 -0.95443 0 0 0 0 0 0 10.2397 0 9.06612 0 0 0 0 0 0 A0A8I3MCG1 A0A8I3MCG1_CANLF Dynein regulatory complex subunit 4 (Growth arrest-specific protein 8) GAS8 Canis lupus familiaris (Dog) (Canis familiaris) cell motility [GO:0048870] cytoplasm [GO:0005737]; microtubule [GO:0005874]; motile cilium [GO:0031514] microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] MMEVSMQNKRLADPLQ;VLEQVQQERDELYRK 2 6.5 0.99132 -0.14842 0 10.522 0 0 0 0 0 0 0 0 0 0 13.1674 0 0 A0A8I3MCJ3 A0A8I3MCJ3_CANLF Amyloid beta precursor like protein 1 APLP1 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] heparin binding [GO:0008201]; transition metal ion binding [GO:0046914] ELAPAGTGRSPMGLS;GEFVSEALLVPEGCRFLHQERM;SSGKEKMSPLE;TDGVDVYFGMPGE;TVPLRRRVRGALR;VLEYCRQM 6 11.8 0.94275 0.059561 0 0 0 0 0 0 0 4.73601 0 0 0 0 0 0 0 A0A8I3MCK3 A0A8I3MCK3_CANLF Proline rich 19 PRR19 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] QPPSPLLPGTSAL;SLSWVVAQSSPEA 2 7.2 0.87217 0.14297 0 0 0 9.57745 0 0 0 0 0 9.87155 0 0 0 0 0 A0A8I3MCN5 A0A8I3MCN5_CANLF UPF2 regulator of nonsense mediated mRNA decay UPF2 Canis lupus familiaris (Dog) (Canis familiaris) "animal organ regeneration [GO:0031100]; liver development [GO:0001889]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145] RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] DDDEGEEEEEENT;EEEKKKQE;FPIDIDYM;NDDDEGEEEEEENTDYLTDSNKEN;NEPEEEEGSDND;NEPEEEEGSDNDDDEGE;NEPEEEEGSDNDDDEGEEE;YFQRYVWWK 8 4.6 1.0035 -1.6075 0 0 0 3.18842 10.2258 0 5.18372 9.32414 0 0 0 6.59713 0 0 0 A0A8I3MCP6 A0A8I3MCP6_CANLF Large ribosomal subunit protein eL34 (60S ribosomal protein L34) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] RLSRTPGNRIVYLY 1 12.1 0.93937 0.060769 0 0 0 0 0 0 0 0 0 0 7.14292 0 0 0 0 A0A8I3MCR2 A0A8I3MCR2_CANLF Uncharacterized protein RFPL4A Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630] RCGYSKQNRRVRPERFDYA 1 6.6 0.95319 0.049524 0 0 0 0 0 0 0 10.5216 0 0 0 0 0 0 0 A0A8I3MCR4 A0A8I3MCR4_CANLF F-box protein 15 FBXO15 Canis lupus familiaris (Dog) (Canis familiaris) ISGLGWVI;YGLHGYQLHVDMHSG 2 4.8 1.0048 -1.0505 0 0 0 0 3.92865 5.52334 0 0 0 0 0 0 0 0 0 A0A8I3MCU2 A0A8I3MCU2_CANLF RAN guanine nucleotide release factor RANGRF Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] FEDVGGMQEARALQV;LALRSYCQEAWVLSGKQQV;VLSGKQQVAKE 3 25.3 0.99386 -0.079972 6.69265 0 0 9.03829 0 0 0 0 0 0 0 0 0 0 6.92053 A0A8I3MCV0 A0A8I3MCV0_CANLF Aquaporin 8 AQP8 Canis lupus familiaris (Dog) (Canis familiaris) ammonium import across plasma membrane [GO:0140157]; B cell differentiation [GO:0030183]; cellular detoxification [GO:1990748]; cellular response to cAMP [GO:0071320]; hydrogen peroxide transmembrane transport [GO:0080170]; regulation of cholesterol biosynthetic process [GO:0045540] intracellular canaliculus [GO:0046691]; intracellular vesicle [GO:0097708]; mitochondrial inner membrane [GO:0005743]; smooth endoplasmic reticulum [GO:0005790] ammonium channel activity [GO:0008519]; methylammonium channel activity [GO:0015264]; urea channel activity [GO:0015265]; water channel activity [GO:0015250] RLFIGDGKTRLILKGR 1 6.1 0.96101 0.049233 0 0 0 8.00764 0 0 0 0 7.95385 0 0 0 0 0 0 A0A8I3MCZ2 A0A8I3MCZ2_CANLF Zinc finger protein 536 LOC119863924 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DSEASGNFEDPTAVKAGCSA;EDDARKNRKYPCPLCGKRFRFN;EKAHITAESAQGQG;GVLSSADHSGQASGMAPEAPS;HKRDRKGD;IGRAYQSIVNNGVNFQGS;PLEGSRDFLSHGL;PSDFYKQFGVYPGL;SQKLHQITS;VLNGQYAMSQKLHQIT;WPGLVDPAFCNFPSDFYKQ 11 11.5 1.0017 -1.4701 0 9.59044 6.2084 6.96682 0 11.5358 10.2701 9.54328 0 8.52638 0 0 0 3.90968 0 A0A8I3MD07 A0A8I3MD07_CANLF Zinc finger protein 507 ZNF507 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] KNETTSDIAVTADSPKTQ;PPSMEYCVLLFCCCICGFE;SPEKKDSEL;VAEMGKRKWY;VNDHENDANSHAQSK 5 7.4 1.0015 -0.70068 0 10.3789 0 0 0 0 0 0 10.7968 0 0 0 0 10.8347 8.02691 A0A8I3MD28 A0A8I3MD28_CANLF Kin17 DNA and RNA binding protein KIN Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; DNA replication [GO:0006260] nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723] HGAAGAAEG;IEEEKKRTAR;LDEIMEIEEEKKRTARTDHWLQPEI 3 6.1 0.99196 -0.27195 0 0 0 0 0 0 0 0 0 8.85807 0 0 0 0 0 A0A8I3MD29 A0A8I3MD29_CANLF 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) MMP2 Canis lupus familiaris (Dog) (Canis familiaris) collagen catabolic process [GO:0030574]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DQSTIETMRKPRCGN;EKIDAVYEAPQEEKAVFF 2 5.4 0.94247 0.10222 0 0 0 8.77377 0 0 0 0 0 0 0 8.74359 0 0 0 A0A8I3MD46 A0A8I3MD46_CANLF Hexosyltransferase (EC 2.4.1.-) CHSY1 Canis lupus familiaris (Dog) (Canis familiaris) bone morphogenesis [GO:0060349]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; sulfation [GO:0051923] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580] glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510] KYSNTEIHPEDLQLGIPPSFMRFQ;MHDHYLDKYEWFMRAD;PKIVYSGKVPS;RRMVPHIGKCLRE;SFMMLKYMHDHYLDKYEWFMRADDD;TLHPNKNPPYQY;VGSSQFNNESLLF;YEWFMRADDDVYIKG 8 12.8 1.0037 -0.82424 0 0 13.4015 11.0999 10.4995 0 0 0 8.92695 5.45566 0 0 9.0442 10.3708 0 A0A8I3MD51 A0A8I3MD51_CANLF Spectrin repeat containing nuclear envelope family member 4 SYNE4 Canis lupus familiaris (Dog) (Canis familiaris) establishment of epithelial cell apical/basal polarity [GO:0045198] meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear outer membrane [GO:0005640] ARPPASRQSLT;EHLISGQEVLE;GVWGPWAP;VLEAEQDSLSL 4 9.6 1.003 -1.9285 0 0 10.9893 0 0 0 0 0 0 0 0 0 0 11.0442 0 A0A8I3MD66 A0A8I3MD66_CANLF Ring finger protein 225 RNF225 Canis lupus familiaris (Dog) (Canis familiaris) EGGEDDDGEEEEGDS 1 4.5 0.95104 0.053874 0 0 0 0 0 0 0 0 4.76681 0 0 0 0 0 0 A0A8I3MD67 A0A8I3MD67_CANLF Trinucleotide repeat containing adaptor 6A TNRC6A Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytosol [GO:0005829] RNA binding [GO:0003723] AGLSGTNCG;DKRMEIDKHSLNIGDYNRT;ENVQSNKMDLSGG;GGSSTHGT;KTSSFTWGNNINPN;PSSSDPRGISSPS;SSKGLSGK 7 4.7 1.0033 -2.2828 0 0 8.63728 0 0 0 10.7419 0 0 9.97398 10.4554 9.54496 0 0 0 A0A8I3MD82 A0A8I3MD82_CANLF Tetratricopeptide repeat domain 23 like TTC23L Canis lupus familiaris (Dog) (Canis familiaris) GVAWLLQNHGREAYFNLQKAERNM;IFGEEHWKCA 2 11.9 0.99261 -0.15031 9.09714 0 0 0 0 0 9.03436 0 10.3513 0 0 0 0 0 10.7365 A0A8I3MD84 A0A8I3MD84_CANLF Stanniocalcin-2 (STC-2) STC2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; regulation of hormone biosynthetic process [GO:0046885]; regulation of store-operated calcium entry [GO:2001256]; response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] enzyme binding [GO:0019899]; heme binding [GO:0020037]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803] GSLCSILSFCTSAIQR 1 5.3 0.95014 0.056282 0 0 0 0 0 0 0 0 0 0 0 0 4.69092 0 0 A0A8I3MD93 A0A8I3MD93_CANLF Chromosome 6 open reading frame 58 C1H6orf58 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] FENILLDNEQNILWGLPLQ;TASYFENILLDNEQNILWGLPLQN 2 7.3 0.99282 -0.18808 8.65267 0 0 0 0 9.55584 0 0 0 0 0 0 0 0 0 A0A8I3MDC4 A0A8I3MDC4_CANLF Dynein axonemal intermediate chain 3 DNAI3 Canis lupus familiaris (Dog) (Canis familiaris) FVDDWKCLAE;GVFYIGRED 2 2.2 1.0028 -0.76047 0 8.59723 0 0 0 0 0 0 0 0 9.60144 0 0 0 0 A0A8I3MDE2 A0A8I3MDE2_CANLF Mitochondrial import inner membrane translocase subunit Tim21 TIMM21 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150] TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] FVELEPHPR 1 3.7 0.98965 -0.19655 0 0 0 0 0 0 0 9.73924 0 0 0 0 0 0 0 A0A8I3MDF6 A0A8I3MDF6_CANLF Centrosomal protein 126 CEP126 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; non-motile cilium assembly [GO:1905515] centrosome [GO:0005813]; ciliary base [GO:0097546] DLDTKIHLEKN;EESQPPLHGGSSKALKANPQRG;ELTKEKGTEIPK;GVRFLKSILKK;QESRTTSFVPMATRMVLPYNTQ;QQIREQILQQRK 6 8.7 1.0025 -0.72032 0 0 9.88597 0 9.2758 0 0 8.91961 0 0 2.31069 4.26409 0 0 11.0855 A0A8I3MDK7 A0A8I3MDK7_CANLF Zinc finger protein 532 ZNF532 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QHKSPYTC;TVFTLQTLLYRHFDQHIE 2 2.1 1.0036 -1.0561 0 0 8.29057 0 0 0 0 0 9.90872 0 0 0 4.852 0 0 A0A8I3MDK9 A0A8I3MDK9_CANLF Ankyrin repeat and SOCS box containing 7 ASB7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] ALHYAAMH;YNYGADTN 2 5 1.0036 -2.2088 0 0 0 0 0 7.72649 0 0 0 8.44004 0 0 8.82053 0 0 A0A8I3MDL1 A0A8I3MDL1_CANLF Elongation factor 1-alpha Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] ETTTEVKSVE;RLPLQDVYKIG 2 4.7 0.9877 -0.26469 8.95428 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MDN0 A0A8I3MDN0_CANLF Crumbs cell polarity complex component 1 CRB1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CHNNATCED;CYNGGNCSEFQGELKCLCQPGFTG;EPCHNNATCEDSADNYTCHCWPGYT;GVCYSLWDDFSCSCPAN;ITLEDISSSSSLNVK;KAGCERKDWCERQ;NNATCEDSADNYTCHCWPGYTGAQC;RDANVIILH;SEFQGELKCLCQPGFT;SGLLLALEN;VDECQSQPCRNGATC 11 10 1.0027 -2.5241 0 7.61353 0 0 0 6.46177 8.71881 7.57312 6.53907 4.93357 0 8.55708 4.44115 0 10.0656 A0A8I3MDS4 A0A8I3MDS4_CANLF Plasminogen activator inhibitor 1 (Endothelial plasminogen activator inhibitor) (Serpin E1) SERPINE1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of angiogenesis [GO:0045766]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; replicative senescence [GO:0090399] collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; serine protease inhibitor complex [GO:0097180] protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102] DFSEVERARFIVNDW;HYYDILELPYHG;IVNDWVKRHTKGM;LKLVHGFMPHFFRLFR;LMLVNALYFNGQWKT;SYQTRAAGLATDF;TRQLRLLVLPK 7 22.4 0.57658 0.36702 0 9.05878 8.01636 0 7.18368 7.37955 4.19952 0 9.0709 0 0 0 0 3.64501 0 A0A8I3MDS6 A0A8I3MDS6_CANLF Proteolipid protein 2 PLP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FVIYMCDLASKI;GYDAFITYPSSI;VIYMCDLA 3 13.6 1.0023 -0.95931 0 0 0 0 0 0 0 0 11.5089 0 0 0 0 0 0 A0A8I3MDV4 A0A8I3MDV4_CANLF Suppressor of cytokine signaling 6 SOCS6 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008] immunological synapse [GO:0001772] ENQVEQDLVVAPEI;VYDSVQSSGPMVVTS 2 5.4 0.9898 -0.20065 0 0 0 0 0 9.77452 0 0 9.10489 0 0 0 0 0 0 A0A8I3MDY2 A0A8I3MDY2_CANLF E2F associated phosphoprotein EAPP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968] nuclear speck [GO:0016607] TKKKKKKR;VTKKKKKKRHR 2 3.8 0.98139 0.035491 0 0 0 0 0 0 0 0 0 3.33842 0 0 0 0 0 A0A8I3MDZ9 A0A8I3MDZ9_CANLF Zinc finger protein 460 ZNF460 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] ECTECGKTFI;GEKPYECMECGKSFC;SYLKRHQRIHTGEKP;VTTEENLLPE 4 8.1 1.0024 -1.1232 10.8542 0 0 0 0 8.3236 0 8.32089 0 0 0 0 0 0 0 A0A8I3ME03 A0A8I3ME03_CANLF Ig-like domain-containing protein VSTM2B Canis lupus familiaris (Dog) (Canis familiaris) APSDTCRRRCCC;GAQPLTAPSLLPP;GPGGHGAP;GVRRGGAERGGEGR;PGLGGARSGGV;RPGEGAGG 6 9.1 1.0028 -1.5847 8.86118 0 0 9.86323 0 8.29407 0 11.432 11.3981 9.83692 8.05815 0 0 9.01508 8.82677 A0A8I3ME22 A0A8I3ME22_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ERN2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; mRNA processing [GO:0006397]; regulation of gene expression [GO:0010468]; regulation of primary metabolic process [GO:0080090] endoplasmic reticulum membrane [GO:0005789] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521] RLGLLLQLAVLL;SVPLQTDLRRF;TEGWMAPELLQL;TGDLKWTLKDD 4 5.3 1.0024 -0.8429 0 0 0 6.11495 0 0 0 10.8115 0 0 0 0 6.87123 0 0 A0A8I3ME77 A0A8I3ME77_CANLF Complexin-1 CPLX1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; neurotransmitter transport [GO:0006836] cytosol [GO:0005829]; presynapse [GO:0098793] syntaxin binding [GO:0019905] CPSPYDPGSWSEGGD;GPWRVSHHGQGRA;TLLALRVHA 3 8.7 1.002 -1.0015 0 0 0 7.39977 0 0 0 0 6.4449 0 8.13899 0 0 0 0 A0A8I3ME83 A0A8I3ME83_CANLF Transmembrane protein 51 TMEM51 Canis lupus familiaris (Dog) (Canis familiaris) GVEPRTPEE;KRLKPLKVRRIK;LAKRLKPLKVRRIKS 3 9.6 0.9892 -0.2029 0 0 0 0 0 0 0 0 0 4.26409 0 6.29412 0 0 0 A0A8I3ME85 A0A8I3ME85_CANLF Bromodomain adjacent to zinc finger domain 1A BAZ1A Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] chromatin [GO:0000785]; nucleus [GO:0005634] metal ion binding [GO:0046872] DDDDEEGQSEEEEYEIDQD;DKLKLFLKQH;EDSMGGEDDEVDDDDE;EMEDSMGGEDDEVDDDDEEGQ;EQEQKMKEKQEKLKEDEQRNSA;LESEKKARQNL;LPPEIFGDALMVLEFL;PPTFIFTP;RYTSRSQQSTPKT;SEFIDDIELMFSNCFEYNP;SPPKRGRPQVRLPIK;VGEEEREDFDTS 12 10.4 1.0027 -1.8941 0 7.7987 8.12846 8.19869 6.388 0 4.58382 9.83436 9.05341 7.17672 0 8.99249 0 11.5384 11.314 A0A8I3ME90 A0A8I3ME90_CANLF THO complex subunit 1 THOC1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; regulation of DNA-templated transcription elongation [GO:0032784] THO complex part of transcription export complex [GO:0000445] LYRKFWSLQDYFRNPVQCYEKISW;VLTDEQSLWIEDTTKSVYQVSST 2 13.1 0.99158 -0.27211 0 0 0 0 0 0 0 10.9954 0 0 0 0 0 0 0 A0A8I3ME94 A0A8I3ME94_CANLF CCR4-NOT transcription complex subunit 1 CNOT1 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" CCR4-NOT core complex [GO:0030015]; nucleus [GO:0005634]; P-body [GO:0000932] molecular adaptor activity [GO:0060090] AALGLLQKAVEGL;AGSVSQELSETILTM;MQQYDLHLAQS;VGTQAIAHIHNKGS;VQELVHPVVDRSIKIA 5 3 0.98641 -0.4114 0 0 0 0 7.84831 0 0 8.1375 0 0 0 8.4731 0 0 0 A0A8I3MEB8 A0A8I3MEB8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TANAGTYYCAADIHS 1 9.9 0.98597 -0.25832 10.4184 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MED1 A0A8I3MED1_CANLF Transcription factor 25 TCF25 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; RQC complex [GO:1990112] ALFFRSLLPNY;PPEQENGLEDIDLSCI 2 4.4 0.96059 0.049233 0 0 0 0 0 0 0 0 0 0 0 6.59051 0 0 0 A0A8I3MEE1 A0A8I3MEE1_CANLF TM2 domain-containing protein 3 TM2D3 Canis lupus familiaris (Dog) (Canis familiaris) lateral inhibition [GO:0046331] membrane [GO:0016020] AACCCSSPSSTSCP;CGPCAAYAACCCSSPSS;PETDYECSNST 3 12.5 0.93128 0.107 0 0 0 0 0 0 0 3.48568 0 0 0 0 0 4.68173 0 A0A8I3MEE2 A0A8I3MEE2_CANLF "LSM11, U7 small nuclear RNA associated" LSM11 Canis lupus familiaris (Dog) (Canis familiaris) U7 snRNA binding [GO:0071209] EADSKSAVEDSTLSR;FDPLLALYAPR;GAAAGSGVAAAAAAAAGA 3 13.1 0.99515 -0.15354 0 0 0 0 0 9.37228 0 7.60274 12.8283 0 0 0 0 0 7.80665 A0A8I3MEG7 A0A8I3MEG7_CANLF DIX domain containing 1 DIXDC1 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507] cytosol [GO:0005829] gamma-tubulin binding [GO:0043015]; protein domain specific binding [GO:0019904] ACLTRGNLLDVLQEGFNEQQ 1 2.9 0.98427 -0.24332 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5481 0 A0A8I3MEJ0 A0A8I3MEJ0_CANLF Heat shock protein family B (small) member 2 HSPB2 Canis lupus familiaris (Dog) (Canis familiaris) somatic muscle development [GO:0007525] cytoplasm [GO:0005737]; nucleus [GO:0005634] structural constituent of eye lens [GO:0005212] AFLDVSHFTPDE;KFQAFLDVSHFTPDE;LLEVSARH 3 12.6 1.0019 -0.99485 14.6344 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MEJ9 A0A8I3MEJ9_CANLF ATPase H+ transporting V0 subunit e1 ATP6V0E1 Canis lupus familiaris (Dog) (Canis familiaris) "proton-transporting V-type ATPase, V0 domain [GO:0033179]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" ETIWYLKYHW 1 15.4 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.2293 A0A8I3MEL9 A0A8I3MEL9_CANLF Arrestin C-terminal-like domain-containing protein ARRDC4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular vesicle biogenesis [GO:0140112]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] extracellular vesicle [GO:1903561]; plasma membrane [GO:0005886] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ADVVSEEEFCRHVPP;PEGEGEACC 2 5.8 0.98665 -0.32931 0 0 0 0 0 0 0 0 0 0 8.02625 0 0 0 0 A0A8I3MEM7 A0A8I3MEM7_CANLF T cell receptor delta constant TRDC Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] KKLEEYDT;TMRNGTAV 2 8.9 1.0035 -2.2088 0 0 8.65957 0 0 0 0 0 0 0 4.29153 4.78084 11.9625 4.1692 9.29329 A0A8I3MEN6 A0A8I3MEN6_CANLF Zinc finger protein 276 ZNF276 Canis lupus familiaris (Dog) (Canis familiaris) kinetochore [GO:0000776]; nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] CDQGHDYTMDADSSCGAL;DLVAWVHGHAASCGA;VHMSMVHPLTQTQDK;VNVSPTGHRKTCT 4 11.5 0.99563 -0.11434 0 0 6.5891 0 0 0 0 0 0 0 0 0 8.26106 0 9.57092 A0A8I3MEQ6 A0A8I3MEQ6_CANLF Forkhead box protein D1 FOXD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] EKFPAWQNSIRHNLS;VRPLPDSAA 2 3.9 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 0 9.37825 0 0 0 0 A0A8I3MER7 A0A8I3MER7_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) IGF1R Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose stimulus [GO:0071333]; insulin-like growth factor receptor signaling pathway [GO:0048009]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of JNK cascade [GO:0046328] axon [GO:0030424]; insulin receptor complex [GO:0005899] ATP binding [GO:0005524]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548] GVVSQGQPTL;LWEIATLAEQPYQGL;NVTEYDGQDACGSNSW 3 3.1 0.99098 -0.19454 0 0 0 0 0 0 0 0 6.61739 0 0 0 11.6324 0 0 A0A8I3MES2 A0A8I3MES2_CANLF Solute carrier family 66 member 2 (PQ-loop repeat-containing protein 1) SLC66A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FRGCWTSSPAWGDLGRWQ;LQFSVCGLLQVL;MVLMWTSGD;RHLFFLFFFIFF 4 13.2 1.0015 -0.96274 0 0 0 0 0 0 8.04062 12.0793 0 9.90853 0 0 0 0 0 A0A8I3MEU2 A0A8I3MEU2_CANLF DNA ligase (EC 6.5.1.1) LIG1 Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910] DLIYLNGESLV;IPVLLEHGLEHLPEHCRL;LDPPSYNPAKNNYHPIDDAC;VLKRFEEAA 4 6.8 0.98655 -0.3878 0 0 10.2632 0 0 0 0 13.3116 0 0 0 0 0 4.42526 0 A0A8I3MEU4 A0A8I3MEU4_CANLF Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Threonyl dipeptidase) CNDP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosol [GO:0005829]; nucleoplasm [GO:0005654] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] GAKTVIPRKVVGKF;KTVFGVEPDLTRE 2 5.7 0.89779 0.1242 0 0 0 0 0 0 0 0 6.46896 6.09708 0 0 0 0 0 A0A8I3MEV5 A0A8I3MEV5_CANLF RNA binding motif protein 15 RBM15 Canis lupus familiaris (Dog) (Canis familiaris) "branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]" nuclear speck [GO:0016607]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729] FLKFENLD;PLRNLVSY;TKNSSGGG;YEPLDSLDRRRDGWS 4 4 1.0019 -0.90812 0 0 11.4197 0 0 0 0 0 9.06364 0 0 0 0 0 9.53526 A0A8I3MEW0 A0A8I3MEW0_CANLF Phenazine biosynthesis like protein domain containing PBLD Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] isomerase activity [GO:0016853] DTLVQDIRYSPD;LRARKMKLPIFI 2 7.8 0.94161 0.10088 0 0 0 10.184 0 0 0 0 0 0 0 6.06327 0 0 0 A0A8I3MEW5 A0A8I3MEW5_CANLF Mu-type opioid receptor OPRM1 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of pain [GO:0019233] axon [GO:0030424]; dendrite [GO:0030425]; endosome [GO:0005768]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] beta-endorphin receptor activity [GO:0004979]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923] ATTKYRHGSI;LMGTWPFGTI;PSMITAIT 3 7 1.0019 -0.67464 0 10.4902 0 0 0 0 0 0 0 0 12.4822 0 0 0 0 A0A8I3MEX2 A0A8I3MEX2_CANLF LDL receptor related protein 3 LRP3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669] clathrin-coated pit [GO:0005905] AGPPPSGLRDPGCR;CGDGSDEGNCSAPAS;EFVRREAP;QASCQADEFRCDNGKCLPGP;TVDECGDGSDEGNC;VGSAGPPP 6 8.3 1.0024 -2.5887 0 10.0765 0 0 7.74779 0 0 0 10.9831 8.57016 0 0 0 0 0 A0A8I3MEY1 A0A8I3MEY1_CANLF Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855] nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] GCSKEEIVQFFQ;GGYGGFDDYGGYNNYGYGNDGFDDR 2 10.7 0.9881 -0.22764 0 0 0 0 0 0 8.56316 6.12664 0 0 0 0 0 0 0 A0A8I3MEY5 A0A8I3MEY5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YTVFLPDH 1 15.4 0.98936 -0.19975 0 0 0 0 0 0 0 0 0 8.15462 0 0 8.95085 0 9.07004 A0A8I3MF10 A0A8I3MF10_CANLF Doublesex and mab-3 related transcription factor 1 DMRT1 Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; germ cell migration [GO:0008354]; male germ cell proliferation [GO:0002176]; male sex determination [GO:0030238]; meiosis I [GO:0007127]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; positive regulation of male gonad development [GO:2000020]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of nodal signaling pathway [GO:1900107]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737]; female germ cell nucleus [GO:0001674] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AADSSSGDVGSPLGGSPV;AGGFGKAA;PSSQDSGLVSLSSSSPISTEST 3 12.7 0.98742 -0.3779 0 0 0 0 10.8094 0 12.1944 9.06706 0 0 0 0 0 0 0 A0A8I3MF18 A0A8I3MF18_CANLF Tubulin folding cofactor B TBCB Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021] cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634] alpha-tubulin binding [GO:0043014]; microtubule plus-end binding [GO:0051010] MEVTGLSAPT;SAPTVTVFISS;SPASCMELELY 3 11.5 0.9755 0.044087 0 0 10.0965 0 0 0 0 10.4018 0 9.73446 0 0 0 0 0 A0A8I3MF21 A0A8I3MF21_CANLF U1 small nuclear ribonucleoprotein 70 kDa SNRNP70 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" nuclear speck [GO:0016607]; precatalytic spliceosome [GO:0071011]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; U1 snRNA binding [GO:0030619] AGDAPPDD;GGGGGGGD 2 3.6 1.0044 -1.1044 0 0 0 0 5.80877 0 0 0 0 0 0 0 0 0 0 A0A8I3MF23 A0A8I3MF23_CANLF Tektin TEKT1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317] axonemal A tubule inner sheath [GO:0160111]; motile cilium [GO:0031514]; nucleus [GO:0005634] HIANKNQYHRA;IDEVLCTHMRK;LLQPPPKFLPEEWH 3 8.4 0.9899 -0.21141 0 0 0 0 0 0 0 7.50661 0 0 0 10.5029 0 0 0 A0A8I3MF24 A0A8I3MF24_CANLF Biorientation of chromosomes in cell division 1 like 1 BOD1L1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; replication fork processing [GO:0031297] Set1C/COMPASS complex [GO:0048188] AGCMGADA;DEEEEEEEEDEPSG;ETTTPQERSMSNDDGE;KEEISNSRKDNTEALRDYSV;KRKKHYPSSEDELDDNPDVLDSKI;KTAVVACKSGRG;LISTSIAEECEA;SSPGSKPKLTQTDESNK;SSRPERKLSDGHKSRSFKHGSK;SVSEATEDKKDQESD;TGITEEDGEGPASCTG;VIIKRKRGRPRKH;VLNDELRTST;VTSTGITEEDGEGPAS 14 6.7 0.94236 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.14661 A0A8I3MF25 A0A8I3MF25_CANLF Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) MAT2B Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] HVIVHCAAERRPDVV;IKGTFHWSG 2 7.4 0.98497 -0.2467 0 0 0 0 8.12055 0 0 0 0 0 0 0 0 0 0 A0A8I3MF27 A0A8I3MF27_CANLF Plasminogen (EC 3.4.21.7) PLG Canis lupus familiaris (Dog) (Canis familiaris) "blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]" cell surface [GO:0009986]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685] kinase binding [GO:0019900]; serine-type endopeptidase activity [GO:0004252] CNIPECEEECM;ECEEECMHCSGE;ECEEECMHCSGENYE;EEECMHCS;GPWCYTTNPDVRFDYCNIPECEEEC;GVTSWGLGCARPNKPGVYV;KTYRGTMA;LLKLSSPA;LTAAHCLERSS;RFDYCNIPECEEECM;SLLDDYVNTQ;SLLDDYVNTQG;SLLDDYVNTQGA;SLLDDYVNTQGASV;SLLDDYVNTQGASVF;SVPPEQTPVVQ;YCRNPDGEPRPWCFTMDPNKRWEFC;YVNTQGASV 18 16.1 0 75.58 11.3384 10.9435 11.525 6.65292 8.9246 8.63797 13.3969 13.003 12.6476 11.8927 12.1789 11.6347 11.4863 11.6949 11.2966 A0A8I3MF35 A0A8I3MF35_CANLF F-box protein 39 FBXO39 Canis lupus familiaris (Dog) (Canis familiaris) ADLWRYRTIT;SNNRLKSLSIQHLELDRLV 2 7.1 0.99014 -0.19854 10.9 0 0 0 0 0 0 0 0 0 0 0 0 0 9.71194 A0A8I3MF53 A0A8I3MF53_CANLF Structure-specific endonuclease subunit SLX4 SLX4 Canis lupus familiaris (Dog) (Canis familiaris) DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656]; telomeric D-loop disassembly [GO:0061820] "cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; ERCC4-ERCC1 complex [GO:0070522]; Holliday junction resolvase complex [GO:0048476]; nucleoplasm [GO:0005654]; Slx1-Slx4 complex [GO:0033557]" DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] EDLLVAMALSRSE;EHSSLLEC;GVRPLPKRQMVL;HAAATEEAVRHYIRSRPAL;KKELDRFGVRPLPKRQMVLK;LDSDEELELE;PAAKKKRGRANRLVRPSPP;SASQREHQALQDLVDLAGEG;SPPGPSPPSQVITSEVV;VKRWTPLE;YIRSRPALYRKVLLYQPFEL;YQPFELSELQAELKQ 12 8.9 1.003 -1.5297 0 9.17722 9.28919 9.23053 10.9816 11.6264 7.76447 0 10.2189 0 0 0 0 0 8.70774 A0A8I3MF62 A0A8I3MF62_CANLF Branched chain keto acid dehydrogenase E1 subunit alpha TMEM91 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] EDASSSDSD;GVLAVGLGV 2 10.5 0.99024 -0.26207 0 0 0 0 0 4.50894 0 10.5005 10.5314 0 0 0 0 0 0 A0A8I3MF66 A0A8I3MF66_CANLF Solute carrier family 25 member 35 SLC25A35 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ASSPCTWACSS;GLVGLWRGALGGLPRVI 2 9.5 0.983 -0.2556 0 0 0 0 0 0 6.88899 0 0 0 0 0 0 0 0 A0A8I3MF81 A0A8I3MF81_CANLF Limb and CNS expressed 1 LIX1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome maturation [GO:0097352] cytoplasm [GO:0005737] EVISYYSQYSLDEK;VISYYSQYSL 2 5 0.98533 -0.23669 0 0 0 0 0 6.98117 0 0 0 0 0 0 0 0 0 A0A8I3MF99 A0A8I3MF99_CANLF Zinc finger with KRAB and SCAN domains 2 ZKSCAN2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECGKCFSQSSSLIIHQRTH;EPIGWEPEEAS;FCYEDVAGPHEAFSKLWE;GVHWGYEETKTFLDILRETRFYE 4 7.3 0.98648 -0.41753 0 0 0 11.1471 0 0 0 9.5446 0 0 0 0 0 11.2379 0 A0A8I3MFA2 A0A8I3MFA2_CANLF RAN binding protein 17 RANBP17 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] FDWIYPTYL;FEVQKDQFVFRE;GDNHFDNVLQ;LNLQDQGQQNLVM;SKLVSRVSPLPVEQRV 5 5.7 0.98754 -0.36939 0 0 0 0 0 0 8.32292 7.80103 8.74883 3.73498 5.02472 0 0 0 0 A0A8I3MFE0 A0A8I3MFE0_CANLF WD repeat domain 62 WDR62 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; spindle pole [GO:0000922] SPNTPAHPNSTSLPETRPGVPGSVT;TPAHPNSTSLPETRPG 2 1.6 0.87544 0.12947 0 0 8.84084 0 0 0 0 0 0 0 0 0 0 9.24027 0 A0A8I3MFE1 A0A8I3MFE1_CANLF Angel homolog 2 ANGEL2 Canis lupus familiaris (Dog) (Canis familiaris) 3'-UTR-mediated mRNA stabilization [GO:0070935]; negative regulation of mitotic cell cycle [GO:0045930] Cajal body [GO:0015030]; cytoplasm [GO:0005737] 3'-5'-RNA exonuclease activity [GO:0000175]; mRNA 3'-UTR binding [GO:0003730] LSLLTEQDLW;NSVPGSPLYS;QEVQEDHYGAE;RHISSCMRWPGHY;SAITVDYIFYS;VGLGGGREEGGAGAGGPG;YICNHNKDKTKILGDQ 7 15 1.0027 -1.3758 0 10.0315 0 0 0 0 0 12.9834 11.5761 13.1125 0 0 12.1593 0 0 A0A8I3MFE4 A0A8I3MFE4_CANLF HD domain containing 2 HDDC2 Canis lupus familiaris (Dog) (Canis familiaris) 5'-deoxynucleotidase activity [GO:0002953]; metal ion binding [GO:0046872] APADNIPK 1 7.5 0.99557 -0.19037 0 0 0 0 0 0 0 0 15.0567 0 0 0 14.6246 0 14.6159 A0A8I3MFF8 A0A8I3MFF8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PINK1 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine secretion [GO:0014046]; establishment of protein localization to mitochondrion [GO:0072655]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1901525]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of oxidative phosphorylation [GO:0002082]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of protein-containing complex assembly [GO:0043254]; respiratory electron transport chain [GO:0022904]" astrocyte projection [GO:0097449]; axon [GO:0030424]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; C3HC4-type RING finger domain binding [GO:0055131]; calcium-dependent protein kinase activity [GO:0010857]; magnesium ion binding [GO:0000287]; protease binding [GO:0002020]; protein kinase B binding [GO:0043422]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; TORC2 complex binding [GO:1904841]; ubiquitin protein ligase binding [GO:0031625] LGRGLQLGRALLLRFTAK;LHLSLWGEHTL;YPCTLRQYLRENTPSPRLAT 3 8.4 0.88156 0.13252 0 0 5.80426 0 5.64172 0 0 0 0 0 0 0 4.31419 0 0 A0A8I3MFG0 A0A8I3MFG0_CANLF Complement component C6 C6 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579] DGNWSCWSSWSTCDATYKRSRT;EEDCTFSVMENNGQACISDDE;GFIRNEKKLYSVGEEVEI;IPIFYSSKKT;LETDFYKDL;NPIPSVQLMGAGFHFLAGE;VEKQFKVRSI;YKDLISLTKNENQRGLFGGEEQ 8 13.8 1.0024 -1.004 0 9.18817 0 0 0 6.03281 9.80447 0 0 0 0 0 0 0 8.89014 A0A8I3MFG2 A0A8I3MFG2_CANLF "Kaptin, actin binding protein" KPTN Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] actin cytoskeleton [GO:0015629] actin binding [GO:0003779] SQSNVYGLAGGAGGR;SSPLLAMAHVDL 2 5 0.99058 -0.21202 0 0 0 0 0 0 0 9.8231 0 0 0 0 0 0 0 A0A8I3MFG6 A0A8I3MFG6_CANLF Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (Ubiquitin carrier protein B) (Ubiquitin-protein ligase B) LOC100856010 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GAPSENNIMQWNTVIFGPEG 1 17.5 0.9616 0.04875 0 10.5518 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MFH4 A0A8I3MFH4_CANLF CREB3 regulatory factor CREBRF Canis lupus familiaris (Dog) (Canis familiaris) response to unfolded protein [GO:0006986] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DEEDEEDVDDEDHDEGFGS;DNLGEQPTKCSPE;DVDDEDHDEGFGS;EDVDDEDHDEGFG;PEEDEEDEEDVDDEDHDEG;PTKCSPEEDEEDEEDVDDEDHDEG;RRYFWEYSEQLTPSQQERMLRPSE;SEHELSENEEEEEEEEDYEDDKDD;SENEEEEEEEEDYEDDK 9 12.5 0.90536 0.12081 7.07831 0 0 4.50392 0 5.3283 11.5133 0 4.20022 0 5.43736 0 0 9.79307 9.92521 A0A8I3MFI1 A0A8I3MFI1_CANLF "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial" ECHDC3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] GHDLKELTDERS;MLKSLQTDLLHESESKDL;MVDNVALQDGQEGIKAFI 3 16.4 0.99267 -0.17937 0 0 9.02276 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MFJ3 A0A8I3MFJ3_CANLF Uncharacterized protein LOC102154185 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] ASKKLGGDFHGTFSYFDDVPFK;VISPNFSMSQRNLP 2 9.1 0.2803 0.6573 14.1346 0 14.1588 0 12.92 13.0778 0 0 14.2504 0 0 13.3582 0 0 13.808 A0A8I3MFK1 A0A8I3MFK1_CANLF Protein MIS12 homolog MIS12 Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070] kinetochore [GO:0000776]; nucleus [GO:0005634] QFFGFTPQTCMLRIYIAF;QLFLQLILRIPPN 2 15 0.92937 0.10787 0 0 0 0 0 0 0 0 0 3.30819 0 0 7.51365 0 0 A0A8I3MFK2 A0A8I3MFK2_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP8 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968] endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; protein serine/threonine kinase activator activity [GO:0043539] EYLRKLEACEGGGV;KKLSEKKVKSPLHLFST;LLLLLLLL;LLLLLLLLH;LLLLLLLLHLLLSHPGSL;LLLLLLLLL;LLLLLLLLLHLLL;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPPPLLLLLLLLL;PPPPPLLLLLLLLLHLL;PPPPPPLLLLLLLLLHLLL;QEGGIHKEILR;QTFVTQQWKQSKEKSNC 16 9.4 0.9894 -0.52116 4.9202 0 4.01952 0 0 0 9.96737 10.6775 0 0 7.26294 9.70328 10.5525 5.73105 0 A0A8I3MFK3 A0A8I3MFK3_CANLF Sodium/myo-inositol cotransporter 2 (Sodium/myo-inositol transporter 2) (Solute carrier family 5 member 11) SLC5A11 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; sodium ion transport [GO:0006814] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] AEPVMVSLEENPL;AGADMVWWPVGA;CTDQVIVQRSL;LFASNVGSG;LILGLLLGLIRMVLDFVYV 5 10 1.0027 -0.7989 0 0 0 0 0 0 0 0 0 0 0 0 8.86465 5.95534 0 A0A8I3MFK9 A0A8I3MFK9_CANLF Solute carrier family 6 member 16 SLC6A16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FVAFIETM;IPFQNTFSSF;IVWGSPASAIIRWLWCF;VFWSILFFLLLLILGLI 4 7.1 1.0027 -1.8947 0 10.7458 0 0 0 0 0 0 11.9764 0 0 9.40389 0 7.09191 0 A0A8I3MFM4 A0A8I3MFM4_CANLF Transcription initiation factor TFIID subunit 6 TAF6 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cell cycle [GO:0045786]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] cytosol [GO:0005829]; MLL1 complex [GO:0071339]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713] SESMKVVAESMGIAQIQ;VSYRIKEIAQD 2 4.1 0.937 0.092009 14.1704 0 0 0 0 0 0 0 11.4522 0 13.5512 0 0 14.6306 0 A0A8I3MFM7 A0A8I3MFM7_CANLF GLIS family zinc finger 2 GLIS2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation involved in kidney development [GO:0061005]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein localization to nucleus [GO:1900182] non-motile cilium [GO:0097730]; nuclear speck [GO:0016607] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DKPYYCKMPGCHKRYTDPSSLRKH;GEKPYVCPYEGCN;KDAGYCCHWEGCAR;LDEPLDLKLSITKLRA;VLDLSTGVN 5 12.1 1.0031 -0.78487 0 0 0 0 0 13.3447 0 0 0 0 0 0 7.70328 7.34775 0 A0A8I3MFN3 A0A8I3MFN3_CANLF Parkin coregulated PACRG Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104]; spermatid development [GO:0007286] axonemal B tubule inner sheath [GO:0160112]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; sperm midpiece [GO:0097225]; vesicle [GO:0031982] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; ubiquitin protein ligase binding [GO:0031625] LIIPIKNALNLRNRQ;VIPQLIIPIKNALNLRNRQV;WKVEIEKLDYHHYLP 3 13.6 1.0037 -0.83026 0 0 0 0 0 0 0 0 9.81194 0 0 0 3.79056 0 0 A0A8I3MFN5 A0A8I3MFN5_CANLF RNA helicase (EC 3.6.4.13) TDRD12 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] DACECTVMNE;EQLVKDFMN;FDFDHWEECEEDSHF;HRVEVLEMSQK;IFELLEDYSMS;PNVAFDFDHWEECEEDSH;SQQPLAVLRNKIEPCLSIDTSP;VESSVYWP;YKCKYFRDRVVFSAWAGEKFYLA 9 8.7 1.0036 -2.0494 0 0 0 0 0 0 0 6.56867 8.37304 0 11.8207 9.05842 15.3946 0 5.09694 A0A8I3MFN6 A0A8I3MFN6_CANLF ATP synthase subunit b LOC119872230 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] EVKQASIQQIQDAI;FHTGQPSLAPVPPLPEYGG;QIQDAIDTEKSQQALVQKR 3 18 0.9964 -0.099661 0 0 0 0 6.475 9.23604 0 0 0 0 0 0 0 0 0 A0A8I3MFN9 A0A8I3MFN9_CANLF L-Fucosyltransferase (EC 2.4.1.-) LOC102151792 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107] DWMEEEYRHIPGEYV;RDFALLTQCNHSIITVG 2 7.8 0.99203 -0.27047 0 0 0 0 0 0 0 0 0 0 0 0 0 6.14047 0 A0A8I3MFP2 A0A8I3MFP2_CANLF Repulsive guidance molecule BMP co-receptor a RGMA Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] QPPRERLVVT;TIIFKNFQEC 2 4.6 1.0023 -1.2229 0 0 0 0 0 0 0 0 8.48901 0 0 0 0 5.85761 0 A0A8I3MFP4 A0A8I3MFP4_CANLF 5-hydroxytryptamine receptor 3A HTR3A Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888] ETIFIVRLVHKQDLQ;INISLLRLPEKVKLDKTI;PRESSLAVRGLLKEL;VLTTYIWYRQYWTDEFLQ;YWTDEFLQWNPEDFD 5 16 0.99608 -0.013659 4.61212 0 7.61346 0 0 6.51242 4.67327 0 0 0 0 0 0 0 10.3971 A0A8I3MFP8 A0A8I3MFP8_CANLF NudC domain containing 2 NUDCD2 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686] unfolded protein binding [GO:0051082] GAEISGNYTKG 1 5.7 0.98331 0.035491 0 0 0 0 9.64989 0 0 0 0 0 0 0 0 0 0 A0A8I3MFQ4 A0A8I3MFQ4_CANLF SH2 domain containing 5 SH2D5 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic density [GO:0014069] AGGRRASD;EVQILHLLLC;GPAHSDPG;GRYCVEVSVRAAG;SQNVHALVSF;VGSFPVDDLDTQEGVW 6 14.9 1.0005 -2.809 8.69411 8.67885 6.51235 8.92336 8.76636 0 9.45216 0 4.16463 0 9.21963 9.50736 0 0 8.11816 A0A8I3MFQ8 A0A8I3MFQ8_CANLF Spermatogenesis associated 24 SPATA24 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; identical protein binding [GO:0042802] DILNGKENEIKELQQVISQQKQM 1 11.2 0.97836 0.046283 0 0 0 0 0 0 0 0 0 0 0 0 0 8.8351 0 A0A8I3MFR5 A0A8I3MFR5_CANLF Thyroid hormone receptor interactor 11 Canis lupus familiaris (Dog) (Canis familiaris) AVGKGKGT;EEEKRACQLEEETNATT;KHDVSKAETERSAQGIE;KPQGTEEELR;NEILQQAVEEKDTSLTSMTKENTHL;QEENKKLATRIENRGQDMFRETI;TDKIEEYELQP 7 6.2 1.0019 -1.418 0 0 0 9.2567 11.1744 0 0 0 0 10.0703 0 0 4.78246 0 7.26247 A0A8I3MFS3 A0A8I3MFS3_CANLF Zinc finger protein 581 ZNF581 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AFKRASHLARH 1 5.6 0.98371 -0.2525 0 0 0 0 0 0 0 10.2358 0 0 0 0 0 0 0 A0A8I3MFU0 A0A8I3MFU0_CANLF EBF transcription factor 1 EBF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EANSEKTNNGI;QGFTRNSSSVSPHGYVPS;TSMNGYGTAAMSNLGGSP 3 8.4 0.99309 -0.16065 0 0 0 0 5.96525 0 12.1233 0 0 0 0 0 0 0 8.67472 A0A8I3MFU7 A0A8I3MFU7_CANLF Cilia- and flagella-associated protein 20 CFAP20 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] axonemal B tubule inner sheath [GO:0160112]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654] IKLPFLVMI 1 4.7 0.99704 -0.088245 0 0 0 0 0 0 0 0 0 0 0 0 0 11.167 0 A0A8I3MFW1 A0A8I3MFW1_CANLF INO80 complex subunit E INO80E Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] Ino80 complex [GO:0031011] AGSGDDALDGDDD;KFLIYEHEC 2 10.7 1.0013 -0.74465 0 0 0 0 0 5.69271 0 9.47245 0 0 0 0 6.72479 0 0 A0A8I3MFW3 A0A8I3MFW3_CANLF Solute carrier family 8 member A2 SLC8A2 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] plasma membrane [GO:0005886] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] GPGTIVGSAAFNMFVVIAVCIY;GVHYEDACGE;KPGETQKELRIGI;RGSCCLCGS;SIELDGTFVGAEVP;TVTILDDDHAGI 6 9.4 0.99237 -0.27195 0 0 0 0 0 0 0 0 0 0 0 0 8.71751 0 0 A0A8I3MFZ4 A0A8I3MFZ4_CANLF KIAA0408 KIAA0408 Canis lupus familiaris (Dog) (Canis familiaris) EDKPACEDRVGLGGRRG;GNQMCKEQKATKKSKVVFTDPLATD;GVAAQNGP;VCPGLRTSGEESRSSSGALN 4 11 1.0028 -0.97402 3.24879 0 0 0 0 0 7.95873 0 0 0 8.15861 0 9.68837 10.4701 0 A0A8I3MFZ6 A0A8I3MFZ6_CANLF Family with sequence similarity 43 member B FAM43B Canis lupus familiaris (Dog) (Canis familiaris) FAWVYRHQAR;FLRSCPDL;LPWRRNKFVLV 3 8.8 1.0042 -1.0871 9.26995 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MFZ7 A0A8I3MFZ7_CANLF ATP binding cassette subfamily B member 10 ABCB10 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hemoglobin biosynthetic process [GO:0046985] mitochondrial inner membrane [GO:0005743] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803] GVPAAAAAPGDDSQLRPA;QLNPVWLR;TSALDAENEYL;VGFLAMSSVITMSA 4 6.9 1.0022 -0.76526 10.6417 0 0 0 7.85636 0 0 0 0 0 0 0 7.53807 0 0 A0A8I3MFZ9 A0A8I3MFZ9_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRK Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AEIQARRIAVDWESLGYNITRCH;AGISAGILVFILLLLVVILIV;FILLLLVVILIVKK;ILLLLVVILIVKK;ILLLLVVILIVKKRYICWRRHICIR;LDPNGVITQYEVSYSSI;LLLVVILIVKKRYI;LVFILLLLVVILIVKKR;QVECMSCSMD;QVECMSCSMDC;SWTETHAVNAPTYKLWHL;TVSNLWNST;VECMSCSMDC;VECMSCSMDCDV;VFILLLLVVI;VFILLLLVVILIVKKRYICWRR;VINRIFRICNLTR;YHQDLYDDFEWVHVS;YHYFRGHNESK 19 10.4 0.87333 0.14301 5.27135 0 0 5.48114 0 0 0 0 0 0 0 0 0 0 7.07756 A0A8I3MG00 A0A8I3MG00_CANLF Mediator of RNA polymerase II transcription subunit 7 MED7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019] core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nuclear body [GO:0016604] transcription coregulator activity [GO:0003712] DDSNNCTGQSEQQ 1 5.6 0.9396 0.059561 0 0 0 0 0 0 0 7.06383 0 0 0 0 0 0 0 A0A8I3MG06 A0A8I3MG06_CANLF EWS RNA binding protein 1 Canis lupus familiaris (Dog) (Canis familiaris) GGCSGMGA 1 2.4 1.0039 -1.1044 0 0 7.04909 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MG08 A0A8I3MG08_CANLF PICALM interacting mitotic regulator PIMREG Canis lupus familiaris (Dog) (Canis familiaris) ASKWPGVGASGRQD;DLEPVGAGLQHL;PGTVPAYL;QDREQLQEPEVVLRAAGHPD;QEPEVVLR;TQVKARRRRGPQK 6 27.9 1.0029 -2.3526 0 0 10.7166 0 0 0 0 0 0 0 0 6.07675 8.78732 0 0 A0A8I3MG20 A0A8I3MG20_CANLF Large ribosomal subunit protein eL21 (60S ribosomal protein L21) LOC106558923 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; organelle membrane [GO:0031090]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] PLATYMRIYKKGGIVDIKG 1 11.9 0.95263 0.049882 0 0 0 0 0 0 0 0 0 0 0 0 10.0827 0 0 A0A8I3MG27 A0A8I3MG27_CANLF Ovo like zinc finger 3 OVOL3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] FTQRCSLEAH 1 5.3 0.99064 -0.26804 0 0 0 0 8.66665 0 0 0 0 0 0 0 0 0 0 A0A8I3MG28 A0A8I3MG28_CANLF HEAT repeat-containing protein 1 HEATR1 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904] CLLNICQKLSPD;EVLEVAAD;HFELMMDREIPVQLWAHYIEQL;IKGLLGNPLP;ISPYLEGVLSQVVHLEKITS;KEEAVPKAVSTKSESQEQMLQ;KKKIVYRFLKLVPVLLAIVQHKKM;KKKIVYRFLKLVPVLLAIVQHKKMV;LEQRLLETVLGYI;LLKTRDSSPKVRFAAL;LQTQALYIGCAMLSAQ;LVPKTEEITSDATY;QFSVAVADDSLW;QSDRSLLSRDEVASLLFDPKE;VMRLDDTYSFQ 15 10.7 1.0033 -2.0776 0 0 0 6.22481 9.97742 11.879 11.5714 5.18345 0 7.6749 0 0 0 8.37773 11.4344 A0A8I3MG35 A0A8I3MG35_CANLF PAXIP1 associated glutamate rich protein 1 PAGR1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944] MLL3/4 complex [GO:0044666] nuclear estrogen receptor binding [GO:0030331] EEMELPAD 1 3.1 0.9894 -0.26592 0 0 0 14.8801 14.884 0 0 0 0 0 0 0 0 0 0 A0A8I3MG53 A0A8I3MG53_CANLF Acyl-CoA synthetase family member 3 ACSF3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] nucleotide binding [GO:0000166] EVRIVSEN;LLRPVVKKLGVP;QSITGHTLLERYGM;SENPKKEGCPYVLHA;TLQEGHSLSHRELK;VDEIPRNQMGKIN;VFKDGMYWI;VLSTHHNIRAMVWE 8 17.5 0.99216 -0.20656 0 0 0 0 0 0 9.04491 0 0 0 0 0 0 0 0 A0A8I3MG61 A0A8I3MG61_CANLF Cupin superfamily member 1 CUPIN1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] DVFFSVPEDI;FLNQHQNA;IRTFQKQQEDQGV;PKFQFLNHL;QGTAWIGVVA;VGTQHYIRSACDE;VISGCAKVGII 7 15.7 1.0046 -0.80421 0 0 0 0 0 0 0 0 13.4367 0 0 0 0 0 0 A0A8I3MG67 A0A8I3MG67_CANLF Hypoxia up-regulated protein 1 HYOU1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] LTELRKLC;TPDAKENGTDSVQEEEESPAEGS 2 2.6 1.0034 -1.0581 0 0 0 5.60018 0 0 0 0 0 0 0 0 0 9.70727 0 A0A8I3MG77 A0A8I3MG77_CANLF Vacuolar protein sorting-associated protein 33B VPS33B Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] clathrin-coated vesicle [GO:0030136]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] DEVVRLLN;GVYGDVSCDEWAFSLLP;VIFCPQKFH 3 5.8 0.98641 -0.45389 0 0 0 0 8.95303 8.86558 0 0 0 7.35465 0 0 0 0 0 A0A8I3MG83 A0A8I3MG83_CANLF Peptidase S1 domain-containing protein LOC478220 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] SPLGTPAPLTCA 1 3.2 0.95202 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.80698 A0A8I3MG92 A0A8I3MG92_CANLF Crumbs cell polarity complex component 1 CRB1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] CHNNATCED;CHNNATCEDSADNYTCHCWPGIHC;CYNGGNCSEFQGELKCLCQPGFTG;GVCYSLWDDFSCSCPAN;ITLEDISSSSSLNVK;KAGCERKDWCERQ;RDANVIILH;SEFQGELKCLCQPGFT;SGLLLALEN;VDECQSQPCRNGATC 10 9.3 0.97396 0.041303 5.24865 0 0 0 0 0 0 0 0 0 2.98878 0 0 0 0 A0A8I3MGA3 A0A8I3MGA3_CANLF Sorting nexin/Vps5-like C-terminal domain-containing protein SNX6 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome [GO:0005768] dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091] FFKNMVKSADGVIV;LLVCCEYLA 2 7.8 0.98428 -0.24362 12.7975 0 10.3942 0 0 0 0 12.9072 0 0 0 0 0 0 0 A0A8I3MGA5 A0A8I3MGA5_CANLF von Willebrand factor A domain containing 3A VWA3A Canis lupus familiaris (Dog) (Canis familiaris) AAYREVTQATAGRFHWFG;FHWFGDTGIYESDDI;HEGPLTIEFPNLDKTSAEW;IQLPRKDTICSS;VTHVNQTQDL;WMPREIEVYITCLE;YMGPSCAH 7 7.7 1.0039 -2.0258 0 0 0 6.79233 0 11.0245 0 0 0 0 0 0 0 8.79113 12.8984 A0A8I3MGB9 A0A8I3MGB9_CANLF Glutathione peroxidase GPX2 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686] glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066] WNFEKFLIGPEG 1 6.3 0.98422 -0.25442 8.66324 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MGC5 A0A8I3MGC5_CANLF BCL2 binding component 3 BBC3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; determination of adult lifespan [GO:0008340]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of growth [GO:0045926]; positive regulation of establishment of protein localization to mitochondrion [GO:1903749]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of thymocyte apoptotic process [GO:0070245]; release of cytochrome c from mitochondria [GO:0001836]; T cell apoptotic process [GO:0070231] mitochondrion [GO:0005739] VPSAVSCGLCEPGLP 1 7.8 0.99232 -0.16906 0 0 0 0 0 9.29825 0 0 0 0 0 0 0 0 0 A0A8I3MGD4 A0A8I3MGD4_CANLF Potassium channel tetramerization domain containing 13 KCTD13 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of synaptic transmission [GO:0050806]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149] Cul3-RING ubiquitin ligase complex [GO:0031463]; nuclear body [GO:0016604] identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin-protein transferase activity [GO:0004842] CLIPTVTSPRE;IFEETLNILIY;PAAAEAPSLE 3 9.7 0.98974 -0.51638 0 6.1983 0 0 0 0 0 6.90509 0 0 0 0 9.79839 7.13576 0 A0A8I3MGE1 A0A8I3MGE1_CANLF Protocadherin beta 1 PCDHB1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EITYSLAQNPETILQ;EITYSLAQNPETILQTFQIDSQTG;TVVAMDTGPPSL;YSLVTDRGL 4 5.5 0.37671 0.58666 0 11.5602 11.7533 0 0 10.1687 0 10.346 0 0 0 0 0 11.7679 11.4264 A0A8I3MGE8 A0A8I3MGE8_CANLF Small integral membrane protein 23 SMIM23 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDKKQTLLVLLILVLYV 1 10.1 0.98384 0.046227 0 0 0 0 0 0 0 5.50398 0 0 0 0 0 0 0 A0A8I3MGG3 A0A8I3MGG3_CANLF A-kinase anchor protein 7 RI-RII subunit-binding domain-containing protein AKAP7 Canis lupus familiaris (Dog) (Canis familiaris) PLPPSSQPLPSL;PRAGDSAGAMGQLCCFPF;VLQRYTENRPSWPSGA;VPSAPGGP 4 15.9 0.98788 -0.49638 0 0 0 0 0 0 0 0 0 0 0 10.2066 0 0 0 A0A8I3MGJ1 A0A8I3MGJ1_CANLF Ras-related protein Rab-4 RAB4A Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]; vesicle-mediated transport [GO:0016192] early endosome membrane [GO:0031901]; insulin-responsive compartment [GO:0032593]; plasma membrane [GO:0005886]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ASPPLLLLLLLLLL;ASPPLLLLLLLLLLL;ASPPLLLLLLLLLLLLLLL;ASPPLLLLLLLLLLLLLLLL;GNAGTGKS;GRASPPLLLLLLLLLLLL;GRASPPLLLLLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLA;LLLLLLLLLLLL;LLLLLLLLLLLLAVG;LLLLLLLLLLLLL;LLLLLLLLLLLLLL;LLLLLLLLLLLLLLAVGAR;LLLLLLLLLLLLLLAVGARP;LLLLLLLLLLLLLLAVGARPG;LLLLLLLLLLLLLLAVGARPGG;LLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLAVG;LLLLLLLLLLLLLLLAVGAR;LLLLLLLLLLLLLLLAVGARP;LLLLLLLLLLLLLLLAVGARPG;LLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLA;LLLLLLLLLLLLLLLLAVGA;LLLLLLLLLLLLLLLLAVGARPG;LLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLA;LLLLLLLLLLLLLLLLLAVGA;LLLLLLLLLLLLLLLLLAVGAR;LLLLLLLLLLLLLLLLLL;LLLLLLLLLLLLLLLLLLAVGA;LLLLLLLLLLLLLLLLLLLL;PGGGRASPPLLLLLLLLLL;PGGGRASPPLLLLLLLLLLLLLL;PLLLLLLLLL;PLLLLLLLLLLLLL;PLLLLLLLLLLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPLLLLLLLLLLL;PPLLLLLLLLLLLLL;PPLLLLLLLLLLLLLL;RASPPLLLLLLLLLLLLLL;RASPPLLLLLLLLLLLLLLL;SGLRTATDDDEAGCG;SPPLLLLLLLLLLLLLL;SPPLLLLLLLLLLLLLLL;SPPLLLLLLLLLLLLLLLL 53 12.3 0.9876 -0.46451 8.4451 11.0136 9.27261 8.067 8.88789 3.59503 5.96715 10.2511 10.6893 8.7496 9.17383 7.88509 10.1058 9.44686 9.23915 A0A8I3MGJ7 A0A8I3MGJ7_CANLF SCAN box domain-containing protein LOC100685822 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DAAGPRDVLRHLQE;VGSGGGGP 2 6.7 1.0022 -1.3932 0 7.82515 8.90219 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MGK8 A0A8I3MGK8_CANLF interstitial collagenase (EC 3.4.24.7) MMP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] FGFPRTVKSIDAAVSDENTG;RYDEYKQS 2 6.3 1.003 -1.3838 0 0 0 0 0 0 0 4.77805 0 0 4.57234 0 7.90274 0 0 A0A8I3MGM0 A0A8I3MGM0_CANLF Coagulation factor XIII B chain F13B Canis lupus familiaris (Dog) (Canis familiaris) "blood coagulation, fibrin clot formation [GO:0072378]" PQCFKKCTKP;QEERITCTQEGWSPEPQCFKKCTKP 2 3.9 1.0018 -0.90926 0 0 0 0 8.40382 0 0 0 0 0 0 0 0 10.9574 0 A0A8I3MGM2 A0A8I3MGM2_CANLF Proteasome subunit beta PSMB11 Canis lupus familiaris (Dog) (Canis familiaris) "CD8-positive, alpha-beta T cell differentiation [GO:0043374]; proteolysis involved in protein catabolic process [GO:0051603]; T cell differentiation in thymus [GO:0033077]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839] threonine-type endopeptidase activity [GO:0004298] ALFYVCSD 1 2.8 0.98912 -0.26417 0 0 0 0 0 11.2003 0 0 0 0 0 0 0 0 0 A0A8I3MGN1 A0A8I3MGN1_CANLF Major vault protein MVP Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; ERBB signaling pathway [GO:0038127]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; protein activation cascade [GO:0072376] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903] DLEIRLTQDPFP;VDVQSVEPV;VEELLSKGQDPLA;VEELLSKGQDPLAD;VTRRTGEEWLVTVQDTEAHVP 5 6.3 1.0015 -0.91865 0 10.5665 10.07 0 0 9.39808 0 0 0 9.57012 0 9.72768 0 0 0 A0A8I3MGQ1 A0A8I3MGQ1_CANLF C-X-C motif chemokine receptor 5 CXCR5 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; immune response [GO:0006955]; leukocyte chemotaxis [GO:0030595]; lymph node development [GO:0048535]; positive regulation of cytokinesis [GO:0032467] external side of plasma membrane [GO:0009897] C-X-C chemokine receptor activity [GO:0016494] AIVHAVHAYRHRRL;AYGFIFLLGMMGN;KTVIALHKV;YNLEDMYK 4 11.8 1.0023 -1.7959 0 0 0 9.87546 0 0 0 10.0298 0 0 0 5.08215 0 0 0 A0A8I3MGS2 A0A8I3MGS2_CANLF 3-dehydrosphinganine reductase (EC 1.1.1.102) KDSR Canis lupus familiaris (Dog) (Canis familiaris) 3-keto-sphinganine metabolic process [GO:0006666]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789] 3-dehydrosphinganine reductase activity [GO:0047560] GIGKCIAIECYKQGAFI 1 6.3 0.97646 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.55432 A0A8I3MGS5 A0A8I3MGS5_CANLF Proteasome subunit alpha type PSMA5 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" GVNTFSPEGRLFQVEY 1 6.9 0.96231 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 7.3924 0 A0A8I3MGS7 A0A8I3MGS7_CANLF SH3 domain binding kinase family member 2 SBK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ALGDLGLTRPEGSATP;CFPWDVALAPDPE;TLEEWTEEE 3 10.5 0.99832 -0.60763 0 0 0 0 10.203 0 0 0 0 0 0 0 0 0 0 A0A8I3MGU5 A0A8I3MGU5_CANLF CDP-diacylglycerol--inositol 3-phosphatidyltransferase CDIPT Canis lupus familiaris (Dog) (Canis familiaris) phospholipid biosynthetic process [GO:0008654] membrane [GO:0016020] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" LMCCPACWEEGQ 1 3.3 0.95312 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.39652 0 A0A8I3MGU7 A0A8I3MGU7_CANLF Zinc finger CCHC-type containing 2 ZCCHC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] GAEDEPGERGEDGEGEEDA;GGGGGGGG;LELLASPL;PGGGGGGG;PQIEGSTGTVPQ;YWEYTFKVNWSDLSVTTVTKTHQ 6 6 1.0025 -1.0003 0 11.2744 9.11348 0 0 0 0 0 0 5.83814 0 0 0 0 0 A0A8I3MGV7 A0A8I3MGV7_CANLF "Kazrin, periplakin interacting protein" KAZN Canis lupus familiaris (Dog) (Canis familiaris) EDCGDDDPQ;EVHLLRQM;ISDASAAEGDRSSTPSD;LNDIGLSQYS;LVSTGQMQQDARRT;TLESREEQLRD 6 8.6 1.0031 -1.9425 0 3.24149 11.2068 0 0 0 10.8017 0 6.20232 0 0 9.6287 0 0 0 A0A8I3MGV8 A0A8I3MGV8_CANLF Lymphocyte cytosolic protein 2 LCP2 Canis lupus familiaris (Dog) (Canis familiaris) mast cell activation [GO:0045576]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; plasma membrane raft [GO:0044853]; TCR signalosome [GO:0036398] DGEDNDDYE;EDDADYEPPPSND;EEDNGGWSSFEDDY;GAFSESNSGFP;IDGKNRGSRYQCTL;PTDDQDGEDNDDY 6 12.4 1.0019 -0.75402 0 8.64263 0 8.70995 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MGW3 A0A8I3MGW3_CANLF Sperm flagellar 2 SPEF2 Canis lupus familiaris (Dog) (Canis familiaris) sperm axoneme assembly [GO:0007288] manchette [GO:0002177]; sperm midpiece [GO:0097225] AEQVIELEKRDLLDSNDYEEYKNM;AIREKEIHEQIT;EKDPPQLDYTQMLLYFACHPD;KKIQKRLEEDAFA;LMHVRHEKEVLWQNRIFREKQYEER;PGGKGPLK;PPSAFDFV;QNRIFREKQYEERRLKDF;SLMQTELNRFQ;TTALKALQ;YKHMKEDLVHMH 11 8.2 0.98334 -0.24791 0 0 0 0 0 0 7.44741 8.73234 8.21704 0 0 0 0 9.11759 0 A0A8I3MGW4 A0A8I3MGW4_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G2F Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498] EVDWCCHAHDCCY;VGYGCYCGLGGYG 2 12.4 0.91805 0.11912 0 0 0 0 0 0 0 0 0 0 0 5.09123 0 5.1048 0 A0A8I3MGW9 A0A8I3MGW9_CANLF Sperm flagellar 2 SPEF2 Canis lupus familiaris (Dog) (Canis familiaris) sperm axoneme assembly [GO:0007288] sperm flagellum [GO:0036126] protein dimerization activity [GO:0046983] AEQVIELEKRDLLDSNDYEEYKNM;AIREKEIHEQIT;EAERGFSQM;KKIQKRLEEDAFA;LMHVRHEKEVLWQNRIFREKQYEER;PGGKGPLK;PPSAFDFV;QNRIFREKQYEERRLKDF;SLMQTELNRFQ;TTALKALQ;WVDSVTHFHGNCL;YKHMKEDLVHMH 12 6.9 0.9986 -3.0198 0 9.21327 0 6.14278 0 0 13.258 0 0 8.17233 2.26123 0 0 9.76612 8.5144 A0A8I3MH07 A0A8I3MH07_CANLF "Rabaptin, RAB GTPase binding effector protein 1" RABEP1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; protein transport [GO:0015031] early endosome [GO:0005769] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096] CDMCSNYEKQLQ;EEDEQQRFHKKK;FHLRLEQERSQWAQYRESAEREIA;FSQAKRDVQEQMAV;SENTKQEAIDEV 5 9 1.0016 -0.74851 0 4.2201 9.36737 0 0 9.02276 0 0 0 9.05241 0 0 0 0 10.6864 A0A8I3MH09 A0A8I3MH09_CANLF Glutathione S-transferase mu 4 GSTM4 Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364] LDFPNVGRRKRRR 1 15.1 0.94471 0.059633 0 0 0 0 0 0 0 0 0 0 0 0 9.49897 0 0 A0A8I3MH35 A0A8I3MH35_CANLF Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH subunit gamma) PAFAH1B3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] platelet-activating factor acetyltransferase activity [GO:0047179] FSPLHALNFG;VQDVQGDGRWMSLH 2 10.4 0.99203 -0.55068 0 0 0 0 8.03854 0 0 0 0 0 0 0 7.20789 0 0 A0A8I3MH38 A0A8I3MH38_CANLF Iroquois homeobox 6 IRX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAALCCASYESR;AVATAADRLAELHK;PPGSGEADFLRAEPGG;QPPGAGGR 4 11.3 0.87964 0.13861 0 7.26078 0 8.31913 8.18046 0 0 0 0 9.48872 0 0 10.4698 0 0 A0A8I3MH46 A0A8I3MH46_CANLF Methyltransferase like 27 METTL27 Canis lupus familiaris (Dog) (Canis familiaris) S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] EALETVLD;RVTKPGGLVCLTTRTNPSNLR 2 12 0.98928 -0.21548 0 0 8.83248 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MH48 A0A8I3MH48_CANLF Protein phosphatase 6 regulatory subunit 1 PPP6R1 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase binding [GO:0019903] CVSAMLSAGPPSDS;DSEEEEDDDEEDEDDGDGR;EICYKDRIQQFDDED;GGSTDSEEEEDDDEEDEDDGD;GSTDSEEEEDDDEEDEDDGDG;LGNTRLHVVKL;PDQLLTTLEKQE;QPPGVRSGGST;SNMLEGEQSQSVIVSGIQ;TDSEEEEDDDEEDEDDGDG;VGALHALRPRLSRFHQLLL;VPQINDAL 12 14.9 1.0037 -1.651 0 8.81208 0 4.96047 6.58396 0 0 0 9.80924 0 7.89785 0 0 0 0 A0A8I3MH62 A0A8I3MH62_CANLF Solute carrier family 28 member 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] nucleoside transmembrane transporter activity [GO:0005337] SREDLCQCLLQ 1 6.2 0.98056 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 8.87437 0 A0A8I3MH65 A0A8I3MH65_CANLF Nucleophosmin NPM1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of centrosome duplication [GO:0010824]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] AADEDDDDDDDD;AADEDDDDDDDDDDDD;AADEDDDDDDDDDDDDE;AADEDDDDDDDDDDDDEDD;AADEDDDDDDDDDDDDEDDDD;ADEDDDDDDDDDDDDEDD;DDDDDDDDDDDD;DDDDDDDDDDDEDDDDDD;DDDDDDDDDDEDDDDDD;DDDDDDDDDEDDDDDDF;DDDDDDDDEDDD;DDDDDDDDEDDDDDDFDDE;DDEDDDDD;DEDDDDDD;DEDDDDDDDDDDDD;EDDDDDDD;EDDDDDDDDDDD;EDDDDDDDDDDDD;EDDDDDDDDDDDDEDDD;EDDDDDDDDDDDDEDDDD;EDDDDDDDDDDDDEDDDDD;EDDDDDDFDDEEAE;ELHIVEAE 23 14.7 0.33333 0.62492 11.2079 0 8.21539 3.45483 5.59288 0 8.47687 7.70729 8.75612 6.13124 9.02567 9.81482 8.75606 0 0 A0A8I3MH68 A0A8I3MH68_CANLF Kinase (EC 2.7.-.-) ITPKC Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytoplasm [GO:0005737]; nuclear speck [GO:0016607] "inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]" AGGPAGRPDGGGPWAGTEGCSLHTE;DGPLEEPEPGEL 2 5.6 0.9905 -0.21359 0 0 11.2789 0 0 0 0 0 0 0 0 0 11.2928 0 0 A0A8I3MH73 A0A8I3MH73_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to nutrient levels [GO:0031669]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] NKQRREQQRL;SRKAEAERKRDERAAR 2 6.5 0.99434 -0.56222 6.38655 0 0 0 0 0 0 8.11795 0 0 0 0 0 0 0 A0A8I3MH78 A0A8I3MH78_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ESWPSSSGTPSPPSTT 1 8.2 0.9821 -0.25075 0 0 0 0 0 0 0 0 13.2136 0 0 0 0 0 0 A0A8I3MH87 A0A8I3MH87_CANLF CCAAT/enhancer-binding protein CEBPE Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; granulocyte differentiation [GO:0030851]; macrophage differentiation [GO:0030225]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEHEASIDLSAYIESG 1 5.7 0.96017 0.049233 0 0 0 0 0 0 0 0 0 0 0 4.78241 0 0 0 A0A8I3MHA2 A0A8I3MHA2_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP1A3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] GSGGSDSY;KDFTSEQIDEILQ;YSFLIFVYDEIRK 3 3.3 1.004 -1.1044 0 0 0 0 0 0 0 0 0 11.3499 0 0 0 0 0 A0A8I3MHB5 A0A8I3MHB5_CANLF AP-4 complex subunit mu-1 AP4M1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794] IRVDEVSFHSSVLLEE;VGLFGAETQQSKVAP 2 7.1 0.91921 0.11694 0 0 0 0 0 0 5.89419 0 9.47283 0 0 0 0 0 0 A0A8I3MHC4 A0A8I3MHC4_CANLF Tigger transposable element derived 7 TIGD7 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] IKKNKKLILDFVLKQ;TESLSSEDGRIKCMFFPHNTSTLI;VIYKPSKDVWFTRELFSEWFFQNF 3 11.5 0.86875 0.13648 0 0 0 0 0 0 0 10.3433 0 0 0 0 0 4.11545 0 A0A8I3MHC6 A0A8I3MHC6_CANLF C2H2-type domain-containing protein LOC119870876 Canis lupus familiaris (Dog) (Canis familiaris) KDNLTQHKRI 1 2.4 0.99906 -0.61146 0 0 0 4.49876 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MHD6 A0A8I3MHD6_CANLF Methylosome protein WDR77 (Methylosome protein 50) (WD repeat-containing protein 77) WDR77 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GAVELWELD;LDCGLSEVFRSRAHRD;SKFCKYEH;VLSSYRAHSGQVTCVA;VLSSYRAHSGQVTCVAASPHKDSVF 5 12.2 1.003 -2.3061 0 0 0 0 0 10.2247 12.7898 0 9.75811 0 0 9.4219 0 3.61789 9.3875 A0A8I3MHE2 A0A8I3MHE2_CANLF sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) ABHD11 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] ALVFLHGLFGS;DISPVETTSSSD;VETTSSSDFP 3 8.2 0.97529 0.044025 0 12.1087 0 0 0 0 0 0 0 0 10.8179 10.8763 0 0 0 A0A8I3MHF7 A0A8I3MHF7_CANLF Cadherin 15 CDH15 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AGISLGALVIVLASVILLL;DEDQDYSCLWD;GALVIVLASVILLLLLALPVALV;SLGALVIVLASVILLLLLALPVAL;SLGDEDQDYSCLWDW;SYSKDYDPED;VGLDREVVAVYN;VIVLASVILLLLLALPVALV 8 8.3 0.99639 -0.57989 0 8.65148 0 0 7.29287 8.56083 5.85711 0 0 0 0 8.84934 4.0036 0 0 A0A8I3MHG0 A0A8I3MHG0_CANLF Procollagen C-endopeptidase enhancer PCOLCE Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] HQFCGGRL;PDTYCRYD;PSPITDTPLKFYVPCKQC;VSLSFRVFDLELHPACRYD;VTGESGYVASEGFPNLY 5 15.3 1.0024 -1.7942 0 0 0 0 0 9.6822 10.5001 0 10.2596 0 0 0 0 0 0 A0A8I3MHG4 A0A8I3MHG4_CANLF Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) RHCG Canis lupus familiaris (Dog) (Canis familiaris) ammonium homeostasis [GO:0097272]; intracellular monoatomic ion homeostasis [GO:0006873]; regulation of pH [GO:0006885]; transepithelial ammonium transport [GO:0070634] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323] ammonium channel activity [GO:0008519]; ankyrin binding [GO:0030506]; carbon dioxide transmembrane transporter activity [GO:0035379]; identical protein binding [GO:0042802] AAGNGADP;RGYIRVGVENLINA 2 3.6 1.0043 -1.1044 0 0 0 0 0 0 0 0 9.58058 0 0 0 0 0 0 A0A8I3MHH3 A0A8I3MHH3_CANLF Iroquois homeobox 5 IRX5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GPHPAAGELPPG;NIDLEKNDEDEPQKPEGKGDS;PSPAGPAAARLAEDPAP 3 11.3 0.98783 -0.37535 0 0 0 0 0 0 11.4116 0 0 0 0 0 0 0 5.67641 A0A8I3MHH6 A0A8I3MHH6_CANLF Uncharacterized protein VPS26A Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; retromer complex [GO:0030904] AKYEIMDGAPVKGE 1 5.1 0.98197 -0.24924 0 0 0 0 0 6.59826 0 0 6.25963 0 0 0 9.32908 0 0 A0A8I3MHH7 A0A8I3MHH7_CANLF Cytochrome P450 family 2 subfamily S member 1 CYP2S1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" GEELIQAEAQRLVEGSRERI;LLLALLLLLLLLAL;LLLALLLLLLLLALARP;LLLLLLLL;LLLLLLLLALARPRTRGHL;TLLLALLLLLLLLALA 6 13.5 0.95219 0.053374 0 0 0 0 0 6.35928 0 0 0 0 0 0 0 0 0 A0A8I3MHI2 A0A8I3MHI2_CANLF Catenin alpha 3 CTNNA3 Canis lupus familiaris (Dog) (Canis familiaris) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] cytoplasm [GO:0005737]; fascia adherens [GO:0005916] actin filament binding [GO:0051015]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296] DLQVQTFTVEKL;NLACSMSTNEDGIKIVK;NMCKKTRDLRRQ;SGSRMDVLA 4 5.6 1.0021 -0.67984 11.8358 16.7068 0 0 0 0 0 9.41777 0 0 15.9701 0 0 0 0 A0A8I3MHI4 A0A8I3MHI4_CANLF Neuropilin and tolloid like 1 NETO1 Canis lupus familiaris (Dog) (Canis familiaris) IVIILIIISVIVQIKQPR;IVIILIIISVIVQIKQPRK;LFTSFQEPP;LGVLKPLP;NECKRNFVAVYDGS;VIILIIISVIVQIKQ 6 9.4 0.98742 -0.37808 0 0 0 9.01544 7.4116 0 5.88969 0 0 0 0 8.23391 0 9.49492 0 A0A8I3MHI7 A0A8I3MHI7_CANLF Nucleoside diphosphate kinase (EC 2.7.4.6) LOC102155863 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; CTP biosynthetic process [GO:0006241]; endocytosis [GO:0006897]; GTP biosynthetic process [GO:0006183]; nervous system development [GO:0007399]; UTP biosynthetic process [GO:0006228] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] FCIQVGRNFIHGSDSVESAE 1 13.2 0.96134 0.04875 0 0 0 0 5.36992 0 0 0 0 0 0 0 0 0 0 A0A8I3MHJ0 A0A8I3MHJ0_CANLF D-box binding PAR bZIP transcription factor DBP Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAKRSRDARRLKEN;ALGAAGGHRAGLTSRDTPSPV;HYRAVLSRYQAQ;LQGTSKPKEPASCL;PADLALSSI 5 21.5 0.98902 -0.21854 0 0 0 0 0 0 0 0 7.60296 0 9.89948 0 0 0 0 A0A8I3MHJ5 A0A8I3MHJ5_CANLF Chromosome 19 open reading frame 12 C19orf12 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; autophagy [GO:0006914]; mitochondrial calcium ion homeostasis [GO:0051560]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966] EQQKLFNEVTAIVRHLEWTDV;VRHLEWTDVVQ 2 16.3 0.94279 0.083164 0 0 10.2429 0 0 0 0 0 6.91145 0 0 0 0 0 0 A0A8I3MHJ8 A0A8I3MHJ8_CANLF PDZ domain-containing protein LIN7B Canis lupus familiaris (Dog) (Canis familiaris) IRAHATAKA;PCCRQLCGCP 2 3.8 1.0019 -1.4157 0 10.1276 0 0 0 0 0 0 0 0 0 0 0 5.06704 0 A0A8I3MHJ9 A0A8I3MHJ9_CANLF Natriuretic peptides B (Brain natriuretic factor prohormone) (Gamma-brain natriuretic peptide) (Iso-ANP) NPPA Canis lupus familiaris (Dog) (Canis familiaris) blood vessel diameter maintenance [GO:0097746] extracellular region [GO:0005576] hormone activity [GO:0005179] GEERPVGVLAPHD 1 9.2 0.98988 -0.21446 0 0 0 0 0 0 0 0 10.3798 0 0 0 0 0 0 A0A8I3MHK2 A0A8I3MHK2_CANLF Sperm acrosome associated 4 SPACA4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CPGIHMQCGDDEDC;CVFCELTDSKQCPGIHMQCGDDEDC;QCGDDEDCFTGH 3 25 0.98617 -0.2366 0 0 0 0 0 4.89147 0 6.7987 0 0 0 0 0 0 0 A0A8I3MHK4 A0A8I3MHK4_CANLF Double C2 domain alpha DOC2A Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] membrane [GO:0016020]; synapse [GO:0045202] metal ion binding [GO:0046872] PDAALERWHT 1 2.5 0.99978 -0.61146 0 0 0 0 8.66846 8.75054 0 0 0 0 0 0 0 0 0 A0A8I3MHK8 A0A8I3MHK8_CANLF Zinc finger protein 671 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CSRCGKAFSCIS;LDDSQRLLYQDVML;LHSRQQQQHRC;VISEDVFVYF 4 9.6 1.0038 -1.102 0 0 8.48603 0 0 0 0 10.872 0 0 0 0 0 0 0 A0A8I3MHM8 A0A8I3MHM8_CANLF NLR family pyrin domain containing 8 NLRP8 Canis lupus familiaris (Dog) (Canis familiaris) CCQAMASMLL;ELNDILPSLELEDSNPREMPVSLE;LKPFLKHPSFI;QDIERHERFLPCI;RFTSWRKLKPFL;SCSSSCSSCSSSSP;SESGLQILELERCL;SESGLQILELERCLFT 8 9.4 0.99192 -0.54382 0 0 5.427 6.78647 0 0 0 10.225 0 4.56809 0 6.25109 0 11.0153 0 A0A8I3MHN6 A0A8I3MHN6_CANLF Zinc finger protein 574 ZNF574 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAQAPRRFECGTCGKK;ERPYSCPDCGKSY;PQEAVPAE;SATATTTT 4 5 0.99504 -0.15699 10.0358 9.34321 0 8.68475 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MHP3 A0A8I3MHP3_CANLF Sulfate anion transporter 1 (Solute carrier family 26 member 1) SLC26A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] antiporter activity [GO:0015297]; monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271] ADALVWVATAA;GLVLSLLS;GVVPTPTP;PECPRRGG;SPALPCPPPPSPSPTSSPPSPPHTL;SQQPARAGKWLRGV;VLLVLLALAPL;WVQDLLPATRWLRQYR 8 11.1 1.0028 -1.9039 0 0 6.75529 6.50117 7.20594 3.81065 0 11.5551 0 7.01223 6.85462 9.97842 0 8.81182 0 A0A8I3MHR7 A0A8I3MHR7_CANLF InaF motif containing 1 INAFM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PQLELPRSRRRRRR 1 9.7 0.93602 0.060769 5.7298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MHR9 A0A8I3MHR9_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] PEESQEGTFVGN;SGSNGDVS;TVRLFVLDLNDN;VAGEVNQRHFRVD 4 4.8 1.0027 -1.4837 0 0 0 0 0 0 0 0 0 0 6.01382 8.94222 9.48993 0 0 A0A8I3MHT2 A0A8I3MHT2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TAOK2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LLLLLLLP;LLLLLLPL;LLLLLPLL;LSRFWTLCKGWNW;SDNEEEEEEEEEEEEEEEGPEA;SGLLPLLLLLLLPLL;SGLLPLLLLLLLPLLA;SSGLLPLLLLLLLPL;YFELQCRQYK 9 5.5 0.98769 -0.33924 0 5.07022 3.32131 0 0 9.4673 7.84053 0 0 0 0 1.54918 0 0 0 A0A8I3MHT8 A0A8I3MHT8_CANLF Seizure related 6 homolog like 2 SEZ6L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILLPLGLVIVLGS;PPGPPNAIE 2 2.7 1.0016 -0.74439 0 0 0 0 0 0 0 0 0 0 0 0 0 4.23802 8.38267 A0A8I3MHT9 A0A8I3MHT9_CANLF Histone H4 transcription factor HINFP Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628] Cajal body [GO:0015030] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEDDDEDPLEEEFSCLWQEC;EWFYRHVE;IKSHYRKVHEG;RYKEHEDGYMRLQ;VVLCGWKGCTCTFK 5 12.7 0.99197 -0.29466 0 0 6.45035 0 0 0 0 0 0 0 0 0 8.01056 10.718 8.25842 A0A8I3MHU2 A0A8I3MHU2_CANLF "Protocadherin gamma subfamily B, 1" PCDHGB1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] growth cone [GO:0030426]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] HIEIVDENDNAPEVTLM;TMKESPDGSKYPEL 2 3.6 0.98279 -0.25099 0 0 0 0 6.61896 0 0 0 0 0 0 0 0 0 0 A0A8I3MHU5 A0A8I3MHU5_CANLF Lemur tyrosine kinase 3 LMTK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] DEDEDEEEDEEAS;GAFPGGGA;GEDEDEDEEEDEEA;GVGRGEGGV;HPALGCPHPPE;LVSETWASPLFP;PAEEDGEDEDEDE;PAEEDGEDEDEDEE;PPSAVASPGSGLSSPGPK;SGVDAKAGWADNTR 10 6.5 1.004 -0.80421 2.5996 8.10066 0 0 0 0 0 0 0 0 4.03025 4.10047 0 7.65971 0 A0A8I3MHW7 A0A8I3MHW7_CANLF Serpin B10 SERPINB10 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654] serine-type endopeptidase inhibitor activity [GO:0004867] VGASGQIR;VLHFSRDKDLKSCPE 2 5.8 1.0029 -1.3322 0 0 0 0 0 4.23703 10.8874 0 0 0 0 0 0 0 0 A0A8I3MHX3 A0A8I3MHX3_CANLF Lemur tyrosine kinase 3 LMTK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DEDEDEEEDEEAS;GAFPGGGA;GEDEDEDEEEDEEA;GGGGYLSH;HPALGCPHPPE;LVSETWASPLFP;NPEGEDCSGEYTPPAEE;PAEEDGEDEDEDE;PAEEDGEDEDEDEE;PPSAVASPGSGLSSPGPK;SGVDAKAGWADNTR 11 7 1.0033 -1.5807 0 0 13.1365 10.151 0 6.12329 0 10.2112 6.01427 11.9367 0 0 0 0 12.1293 A0A8I3MI23 A0A8I3MI23_CANLF HIRA interacting protein 3 HIRIP3 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; nucleoplasm [GO:0005654] EFICSFFRGRPDLSTLTHS;REEKVDLAK 2 4.9 1.0026 -0.75467 0 0 0 0 0 9.64202 0 0 2.84986 0 0 0 0 10.2484 0 A0A8I3MI28 A0A8I3MI28_CANLF Dynein regulatory complex subunit 7 DRC7 Canis lupus familiaris (Dog) (Canis familiaris) DEDWYLSY;FEKETQEL;KNYWINMQDCWNGC;LTEEEDDGMNDNDDVENLGKEDED;MPYPELYNWDSCAQ;SFEVEPMEHTKKLLYQYEAMMKL;WNGCKDLIFDLGDPVR 7 12.8 0.99304 -0.55592 6.15902 9.22497 6.3773 0 0 0 0 7.27006 0 8.81112 0 0 0 0 9.15932 A0A8I3MI39 A0A8I3MI39_CANLF Adrenocorticotropic hormone receptor (Adrenocorticotropin receptor) (Melanocortin receptor 2) MC2R Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] corticotropin receptor activity [GO:0004978] AFRSPELREAFKKMVFC;CWAPFVLHVLL;NPYCACYMSLFQVNGML 3 15.2 0.99206 -0.20797 0 0 0 0 0 0 0 0 0 0 8.41037 0 0 0 0 A0A8I3MI61 A0A8I3MI61_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AVRRREEAKRI;FIGTPYWMAPE;FQEQLKLMKK;LDYSTSLSADLS;QELRELRLLQKEEHRNQ;RYNQRMIEQ 6 7.6 1.0011 -0.9231 0 0 0 0 9.8553 0 0 0 10.1946 0 12.1989 9.61974 0 6.89336 0 A0A8I3MI65 A0A8I3MI65_CANLF AT-rich interaction domain 4B ARID4B Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] DNA binding [GO:0003677] AEEEEEEEEEDEEDDDNNEEEEF;AGELQDLQSEGNSSPAGF;DDDNNEEEEFECYP;DEEAEEEEEEEEEDEEDDDNNE;DEEDDDNNEEEEFECYPP;EDEEDDDNNEEEEFECYPPG;EEEEEEDEEDDDNNEEEEFECYPPG;ESETLDQLPLTNPE;ESETLDQLPLTNPEHFGTP;NGLEEKRKSLRTTGF;NKEEDEDDEEAEEEEEEEEEDEEDD;RPADKNVPKIKHRKKIKNK;SEVASIDRRRKRLKK;TPPTTPESPSSVTV;VTEAGQQQSSVTVSE 15 11.7 0.98767 -0.37757 8.62103 4.10291 0 9.92349 7.70494 0 6.49614 8.03331 0 2.67525 0 0 0 6.92446 0 A0A8I3MI85 A0A8I3MI85_CANLF Ankyrin repeat and KH domain containing 1 ANKHD1 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] cytoplasm [GO:0005737] FGGHRSGQ;HTALMEACMDGHVE;QVNMPADSFESP 3 5.9 0.99003 -0.2636 0 0 0 0 0 0 0 0 0 0 0 0 9.61121 0 0 A0A8I3MI96 A0A8I3MI96_CANLF Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) CACNG3 Canis lupus familiaris (Dog) (Canis familiaris) "neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; protein targeting [GO:0006605]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]; somatodendritic compartment [GO:0036477] channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245] VHIYIEKHQQ;YLLRAVRA 2 5.7 1.0024 -1.1507 0 0 0 12.0987 0 0 11.3967 11.981 13.9268 0 0 0 0 11.2924 13.1344 A0A8I3MIA5 A0A8I3MIA5_CANLF ATP synthase subunit gamma ATP5F1C Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" YDDIDADVLQNYQ;YSLKESTTSEQSAR 2 9.1 0.91146 0.12062 0 0 7.70453 0 0 0 4.71276 0 0 0 0 0 0 0 0 A0A8I3MIA7 A0A8I3MIA7_CANLF Ankyrin repeat and KH domain containing 1 ANKHD1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AKELEDLIP;DEDEEENDEDVE;GDIEAQSERTKDTPLSLA;HTALMEACMDGHVE;ITIRGGTESTRY;NSCSSSASNT;QKDKNGERMITIRGGTES;QVNMPADSFESP;SLPEDHLSELPQVDTILF;TECLTPEPCSQSP;TRYAVQLINALIQDPAKELEDLIP;VGHSGIWSF;VSDLSPMSMPFASNSEP 13 6.5 1.0028 -1.891 0 9.5044 0 8.58894 8.99882 7.51633 9.83919 10.4443 0 8.71572 0 0 9.59846 0 0 A0A8I3MIB3 A0A8I3MIB3_CANLF DNA-3-methyladenine glycosylase II (EC 3.2.2.21) (3-methyladenine DNA glycosidase) MPG Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] cytosol [GO:0005829]; nucleoplasm [GO:0005654] alkylbase DNA N-glycosylase activity [GO:0003905]; DNA binding [GO:0003677] RGMFMKPGTLYVYIIYGMYFCLNV 1 8.6 0.97445 0.041303 0 0 0 0 7.44675 0 0 0 0 0 0 0 0 0 0 A0A8I3MIC3 A0A8I3MIC3_CANLF Pre-mRNA processing factor 39 PRPF39 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 5'-splice site recognition [GO:0000395] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] pre-mRNA 5'-splice site binding [GO:0030627] IEDITDPAK;NWKEYLEFEIENGTHERVV;VEQSADFSTEIMN 3 6.7 1.002 -1.3214 0 0 10.3492 0 0 0 0 0 0 0 0 0 0 9.98868 10.1538 A0A8I3MIC6 A0A8I3MIC6_CANLF Olfactory receptor LOC119872308 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LETMGYIS;TYIVLRIL;YTTIMSNKICMQ 3 13 1.0005 -0.92704 0 0 0 0 0 0 0 9.38278 0 0 0 8.89851 0 0 0 A0A8I3MID1 A0A8I3MID1_CANLF Inter-alpha-trypsin inhibitor heavy chain 2 ITIH2 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] LVSDPESGILVNGE;NVRTWRNDL;STETITLSQGSR 3 3.9 0.98679 -0.33638 0 11.892 0 0 0 0 0 9.45206 9.41369 0 0 0 14.9846 0 9.4707 A0A8I3MID2 A0A8I3MID2_CANLF Angiotensin II receptor associated protein AGTRAP Canis lupus familiaris (Dog) (Canis familiaris) VLLLRLPHV 1 8 1.0039 -0.80421 0 0 0 0 0 0 0 0 7.1178 0 0 0 0 0 0 A0A8I3MID6 A0A8I3MID6_CANLF ADP-ribosylation factor 1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139]; postsynaptic density [GO:0014069] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EAGPMACAVCFTA;ILYKVKLGEIVTTI;TVWDIGGQDK 3 17.8 1.0013 -0.70515 9.02807 0 0 0 0 0 0 0 0 10.6964 0 0 5.28148 0 0 A0A8I3MID8 A0A8I3MID8_CANLF Angiopoietin like 5 ANGPTL5 Canis lupus familiaris (Dog) (Canis familiaris) GVQWGTWTKNSAPV;LTTEVFRKQLEPL 2 7 0.99014 0.014631 0 0 8.32553 11.7501 11.7098 0 12.5876 0 12.6481 0 0 12.2087 0 13.9597 13.8926 A0A8I3MIE1 A0A8I3MIE1_CANLF Striatin-interacting protein 1 (Protein FAM40A) STRIP1 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866]; regulation of cell morphogenesis [GO:0022604] cytosol [GO:0005829]; nucleus [GO:0005634] protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] DNLDAFNERDP;EQVPAETLY;ESPDLEFEYADTD;GAPRAGGG;LTAGKSGPLRLWCPG;LTCPKGLPWA;TPASARAA;VIVKAISAVLLLLLK;VNRHKEVIVKAISAVLLLLL;VTDKKWTELD;YKADDSREEEEENDDDNSL 11 12 0.99761 -3.7449 0 0 11.4046 7.92386 8.05989 0 9.34123 11.0839 0 0 0 0 0 8.16752 5.01641 A0A8I3MIE2 A0A8I3MIE2_CANLF Phosphoinositide interacting regulator of transient receptor potential channels PIRT Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to pain [GO:0048266]; phosphatidylinositol-mediated signaling [GO:0048015]; response to heat [GO:0009408] plasma membrane [GO:0005886] "phosphatidylinositol bisphosphate binding [GO:1902936]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; transmembrane transporter binding [GO:0044325]" ILLFGVVITCLAY 1 9.4 0.94105 0.05973 0 0 2.97501 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MIE7 A0A8I3MIE7_CANLF Coronin LOC102152446 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GPSSKFRHAQGTV;LDTSPGSLMLLLDPDSGL;SQGEDKRQVTYL;SRLSCYEVLPQQPA;VLGLDVAPSTLLPS;VTDLAWDPFDPYRLAVGGEDARIRL 6 11.5 1.0022 -1.2714 0 0 0 0 0 9.35167 9.33588 9.53858 0 0 0 0 9.73269 0 0 A0A8I3MIE8 A0A8I3MIE8_CANLF Family with sequence similarity 13 member C FAM13C Canis lupus familiaris (Dog) (Canis familiaris) EEDSDEDCPQ;EEEDSDEDCPQ;KFEEKFEQ;LKRKIRKFEEKFEQEKK;TAVTEDEDNKENY;TGRSPQKEDRIPM 6 9.2 0.9957 -0.56713 9.34116 0 7.71754 0 0 0 0 0 0 0 0 0 6.57666 11.9335 0 A0A8I3MIE9 A0A8I3MIE9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DLLRVTGD 1 8 0.53297 0.4407 0 0 11.351 11.1892 0 0 11.5741 11.5341 0 0 0 11.2566 0 0 0 A0A8I3MIF5 A0A8I3MIF5_CANLF Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) HK1 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] LVKMAKESLLFEG;MMTCGYDDQQ;SEHSPNWPCGSAKAWETGIDK;YMEEMKNVEMLEG 4 6.2 0.97805 0.047591 0 0 0 0 0 0 0 6.46084 0 0 0 0 0 0 0 A0A8I3MIH1 A0A8I3MIH1_CANLF "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" MGAT2 Canis lupus familiaris (Dog) (Canis familiaris) oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation via asparagine [GO:0018279] Golgi membrane [GO:0000139]; Golgi stack [GO:0005795] "alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]" MRFRIYKRKVLILT;VIFSHDFWSTEINQLIAG 2 7.2 0.99699 -0.5895 9.14995 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MIH4 A0A8I3MIH4_CANLF Cyclin Y CCNY Canis lupus familiaris (Dog) (Canis familiaris) regulation of canonical Wnt signaling pathway [GO:0060828] cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; plasma membrane [GO:0005886] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901] KNRDPDGRMLLDI;NIDDLNMEFNP;YHIKNRDPDGRMLLDIFDE 3 9.6 0.99054 -0.51199 0 9.75562 0 0 0 10.106 0 0 0 0 0 0 0 0 0 A0A8I3MII9 A0A8I3MII9_CANLF Trehalase (EC 3.2.1.28) (Alpha-trehalose glucohydrolase) TREH Canis lupus familiaris (Dog) (Canis familiaris) trehalose catabolic process [GO:0005993] "alpha,alpha-trehalase activity [GO:0004555]" KYRNLWQQRLA;RFRELAATH;SDSSHYVGPLGGGQL;SPGGLWLDQW;VLSHPEQFSLIYAA 5 9 1.0039 -0.82891 0 0 0 0 12.1205 8.62695 0 0 0 6.52337 0 0 4.01185 0 0 A0A8I3MIJ3 A0A8I3MIJ3_CANLF Cytoplasmic polyadenylation element binding protein 1 CPEB1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-UTR binding [GO:0003730]; translation regulator activity [GO:0045182] PFPCLQFLIAPCC;PLGSDLVD;QAAAVNEATY;SLTGCDRPWSTQD;VEIKTTKFSKKV 5 7.3 1.0036 -2.235 0 0 8.9558 0 10.7192 0 0 0 0 0 0 0 0 6.14963 0 A0A8I3MIJ7 A0A8I3MIJ7_CANLF Zinc finger protein 131 ZNF131 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAEFLQMLEAI;ELRRHLSDTHN;QEPLVEIEG;TESFKCEICN;VIHTGDKPNHCTLCD 5 9.5 1.0021 -1.2777 0 7.41853 3.41738 0 0 3.4167 8.54098 0 11.4469 0 0 0 0 0 0 A0A8I3MIJ9 A0A8I3MIJ9_CANLF GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) GDPGP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GDP-D-glucose phosphorylase activity [GO:0080048]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166] APSEPLDPGGHL;EDIYVMINVSPLEWGH;PIKTSQDFGTLTEAAALALIQD;PQRLLPAA;VLCSAWRQRMELGLFR 5 18.8 0.98616 -0.4285 0 11.7555 0 0 0 0 0 8.02857 0 0 0 0 0 6.45307 6.23419 A0A8I3MIK5 A0A8I3MIK5_CANLF Thyroid hormone receptor interactor 6 TRIP6 Canis lupus familiaris (Dog) (Canis familiaris) chordate embryonic development [GO:0043009]; positive regulation of cell migration [GO:0030335]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886] interleukin-1 receptor binding [GO:0005149]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] EIDSLTSMLAE;PPRQLEPARAP 2 4.6 0.99218 -0.29531 0 12.459 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MIK7 A0A8I3MIK7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ALRPLVKPKIVKKRTKK;ALRPLVKPKIVKKRTKKFIQ;HQSDPICR 3 20.1 1.0029 -1.01 0 0 0 0 0 0 0 8.61386 0 7.71253 0 9.66322 0 0 6.27038 A0A8I3MIM4 A0A8I3MIM4_CANLF Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) PPIP5K2 Canis lupus familiaris (Dog) (Canis familiaris) inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958] cytosol [GO:0005829] ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate kinase activity [GO:0000828] EDEEEEDESPPER;EVNGEVFQKPFVEKPVS;KLKLKKPKQLQ;QFHIPWSIPLEAEDIPI;QTVCGFDLLRANGQS;RHGDRTPKQKMK 6 7.7 0.99421 -0.0099602 0 13.0545 0 0 7.41109 0 0 0 0 6.85773 0 0 10.8503 0 9.25304 A0A8I3MIM5 A0A8I3MIM5_CANLF FXYD domain containing ion transport regulator 3 FXYD3 Canis lupus familiaris (Dog) (Canis familiaris) DPEDKDSPF 1 14.1 0.98224 -0.2497 0 8.63561 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MIM7 A0A8I3MIM7_CANLF Ras-related protein Rab-28 RAB28 Canis lupus familiaris (Dog) (Canis familiaris) regulation of exocytosis [GO:0017157] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] FLRRITLP;LVYDITNYQ;VFLCFQKVAAEILGIKLN 3 17.2 1.0029 -2.1698 4.0982 0 0 0 0 0 0 10.0943 0 0 0 0 0 0 0 A0A8I3MIN2 A0A8I3MIN2_CANLF Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase) PLK1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; establishment of mitotic spindle orientation [GO:0000132]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; homologous chromosome segregation [GO:0045143]; microtubule bundle formation [GO:0001578]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear membrane disassembly [GO:0051081]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization to cell cortex [GO:1904776]; synaptonemal complex disassembly [GO:0070194] centriolar satellite [GO:0034451]; centriole [GO:0005814]; chromatin [GO:0000785]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; synaptonemal complex [GO:0000795] anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] EEAEDPACIPIFWVSKWVDYSDK;SDADTKEVFAGKIVPKSLL 2 7 0.92681 0.095949 0 0 0 0 0 0 0 0 0 0 0 4.2302 8.20477 0 0 A0A8I3MIQ1 A0A8I3MIQ1_CANLF Solute carrier family 16 member 9 SLC16A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FYDWTQTYDTAFYFSGFCV 1 4.1 0.94878 0.04956 0 0 5.95877 0 0 0 0 2.74352 0 0 0 0 0 0 0 A0A8I3MIR7 A0A8I3MIR7_CANLF Lysophosphatidylcholine acyltransferase 2 LPCAT2 Canis lupus familiaris (Dog) (Canis familiaris) 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; calcium ion binding [GO:0005509] EIAQGDSVSYEEF;GRIGIEEFAE;ILLAWPFA;SMVSRKENVQVPLIGRLLRALQ;SNKVSPENHDES 5 13.7 1.0022 -0.69175 8.92208 0 0 5.95689 13.4837 0 0 0 0 0 0 16.857 0 0 7.76871 A0A8I3MIS0 A0A8I3MIS0_CANLF Biliverdin reductase B BLVRB Canis lupus familiaris (Dog) (Canis familiaris) heme catabolic process [GO:0042167]; megakaryocyte differentiation [GO:0030219]; negative regulation of insulin receptor signaling pathway [GO:0046627] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] biliverdin reductase (NAD(P)H) activity [GO:0004074]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; riboflavin reductase (NADPH) activity [GO:0042602] GQDAVIVLL;SHSLSPLR 2 6.9 1.0042 -1.1044 0 0 0 0 0 0 0 3.96735 0 0 0 0 0 0 0 A0A8I3MIT0 A0A8I3MIT0_CANLF Dpy-19 like C-mannosyltransferase 3 DPY19L3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] NTSIGNGVKRVISVKINLTALV 1 2.7 0.97416 0.046699 0 0 0 0 0 0 2.61429 0 0 0 0 0 0 0 0 A0A8I3MIT2 A0A8I3MIT2_CANLF Intraflagellar transport protein 46 homolog IFT46 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport [GO:0042073] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DDDDSSETESDEDDDDEEH;DDDDSSETESDEDDDDEEHGAPLE;DDDSSETESDEDDDDEEHG;DDDSSETESDEDDDDEEHGA;DDSSETESDEDDDD;DSSETESDEDDDDEEHGAPLEGAY;ENDDDDDDSSETESDEDDDD;ENDDDDDDSSETESDEDDDDEEHG;ETESDEDDDDEE;FSENDDDDDDSSETESDEDDDDE;GWGSFYTGETDSEG;NDDDDDDSSET;NDDDDDDSSETESDEDDDD;NKTMADNSSDEYEE;QTYDERLEINDS;SSETESDEDDDDEEHG 16 12 0.087379 0.88992 0 9.26777 11.1519 7.59246 0 8.0511 0 0 6.48451 8.07644 0 8.42337 7.07788 6.91444 8.23304 A0A8I3MIU8 A0A8I3MIU8_CANLF Alpha kinase 2 ALPK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GPSHDVPEN;GVPVHRLFETSGVPG;ISQKASEGGP;IYAAEAQPLEGFGE;KEPVKHPLTQSDKRAG;KSHKIWEME;NSDTNASRSENPLDVT;QERPSPGGPGGLE;SGSDGLKEEVSDSGH;SLSPKYLNQPR;TEEFSDDD;VQLPGGDKRPSTSAPDTTA 12 7.6 1.0035 -2.3854 4.93461 5.05059 8.47626 8.44332 0 4.38881 0 8.55328 10.1717 0 5.87273 5.14971 10.5353 12.0286 0 A0A8I3MIV2 A0A8I3MIV2_CANLF N-alpha-acetyltransferase 60 (EC 2.3.1.259) (EC 2.3.1.48) (Histone acetyltransferase type B protein 4) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) NAA60 Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059] peptide alpha-N-acetyltransferase activity [GO:0004596] AARQPGPGHHASP;HVLTTNNTAINFYENRDFKQHH;KDGFTYVLYING;RAAPRLGCLRPQDAL;YENRDFKQHHYLPYYYSIRGVL 5 17.3 0.99162 -0.040993 8.10507 8.44406 0 0 5.65687 0 0 0 0 0 0 0 9.38612 4.04256 13.0922 A0A8I3MIW3 A0A8I3MIW3_CANLF DUF4706 domain-containing protein C4H1orf198 Canis lupus familiaris (Dog) (Canis familiaris) AAAIAASRS;GGGAGGGR;GGGAPGGA;GGGGGRPG 4 4.6 1.004 -1.1044 0 0 0 0 0 7.74712 0 0 0 0 0 0 0 0 0 A0A8I3MIW7 A0A8I3MIW7_CANLF Family with sequence similarity 241 member B FAM241B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPSRSSTPRQS 1 9.2 0.98184 0.035491 0 10.3793 0 0 0 0 0 0 0 0 3.50271 0 0 0 3.32409 A0A8I3MIW9 A0A8I3MIW9_CANLF Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) WTAP Canis lupus familiaris (Dog) (Canis familiaris) "mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] identical protein binding [GO:0042802] DCSRLANG;DSNHDPQE 2 4 1.0033 -1.6145 0 0 0 0 0 0 0 0 0 4.89569 0 0 0 0 0 A0A8I3MIX2 A0A8I3MIX2_CANLF Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1) RPF1 Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" rRNA primary transcript binding [GO:0042134] AGGKSGGG;FIGRQVATFHNQ;GEYEWVHKPREMDTSRRKFHL;GGKSGGGG;QQRKEKLAIKKKLKK;RKEKLAIKKKLKKE;WKQQQRKEKLAIKKK;YIFKSEKKVGIQELGPRFTLK 8 23.5 1.0031 -1.384 0 0 12.8187 0 9.41081 4.73433 9.87215 9.72983 9.90109 0 0 0 12.665 0 0 A0A8I3MIY1 A0A8I3MIY1_CANLF NIM1 serine/threonine protein kinase NIM1K Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] GVPYPTPL;LDPKHLSETSTLKDEENEVKSTLEH;LVTPHYAR 3 9.4 1.0026 -2.1732 0 0 0 0 0 0 8.94857 8.46528 0 0 5.9273 0 0 0 0 A0A8I3MIZ4 A0A8I3MIZ4_CANLF [tau protein] kinase (EC 2.7.11.26) GSK3A Canis lupus familiaris (Dog) (Canis familiaris) autosome genomic imprinting [GO:0141068]; cardiac left ventricle morphogenesis [GO:0003214]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to interleukin-3 [GO:0036016]; cellular response to lithium ion [GO:0071285]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glycogen metabolic process [GO:0005977]; insulin receptor signaling pathway [GO:0008286]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of autophagy [GO:0010508]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of mitophagy [GO:1901524]; regulation of neuron projection development [GO:0010975]; regulation of systemic arterial blood pressure [GO:0003073] axon [GO:0030424]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor binding [GO:0005102] GGGGGGGG;GGGGGGPG;PGGGGGGG;VGASSSGG 4 4.3 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 8.41789 0 0 0 0 A0A8I3MJ03 A0A8I3MJ03_CANLF Teashirt zinc finger homeobox 3 TSHZ3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] AGGAVLLLLLLLLLLLLLP;AVLLLLLLLLLLLLLP;AVLLLLLLLLLLLLLPRR;EQMKAVYNNFLSNSYWSNLH;GAVLLLLLLLLLL;GAVLLLLLLLLLLLLL;GAVLLLLLLLLLLLLLPR;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLL;LLLLLLLLLLLLLPR;LLLLLLLLLLLLLPRR;LLLLLLLLLLLLLPRRH;LLLLLLLLLLLLLPRRHLLL;LLLLLLLLLLLP;LLLLLLLLLLPRRHLLL;LLLLLLLLLPRRHLLL;LLLLLLLLLPRRHLLLP;LLLLLLLLP;LLLLLLLP;LLLLLLPRRHLLLP;LTVHMNETGHYR;MLFKMSNSLAEKAAV;PLPGGGGG;SHSAGGAVLLLLLLLLLLLL;SHSAGGAVLLLLLLLLLLLLLPR;SSHEMDSESHISETSDRMAD;TSEIVSPT;VLLLLLLLL;VLLLLLLLLLL;VLLLLLLLLLLL;VLLLLLLLLLLLL;VLLLLLLLLLLLLL;VLLLLLLLLLLLLLPR 37 7.4 0.99217 -0.16906 10.9747 8.76125 10.6005 7.23141 8.49562 8.57285 8.41924 9.42402 6.75275 5.1784 0 7.25795 7.27314 5.93541 8.21665 A0A8I3MJ04 A0A8I3MJ04_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] ETETVILHCTYDTSN;TNNRFSVNF 2 24.2 1.0017 -0.75032 0 8.97223 0 0 0 0 0 0 8.93952 0 0 0 0 4.88328 0 A0A8I3MJ13 A0A8I3MJ13_CANLF "Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (p160 ROCK-1)" ROCK1 Canis lupus familiaris (Dog) (Canis familiaris) Rho protein signal transduction [GO:0007266] bleb [GO:0032059]; centriole [GO:0005814]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] DTPFYADSLVGTYSK;EVQLVRHKSTR;LEHLTENKERM;LVGTYSKIMNHKNS;RKVYAMKL;SPEVLKSQGGDGYY;VGFTYYSNRRY 7 6.7 1.0021 -0.64955 0 9.35198 0 0 10.1016 0 0 0 10.9753 0 0 0 6.00146 0 0 A0A8I3MJ16 A0A8I3MJ16_CANLF Protein yippee-like YPEL3 YPEL Canis lupus familiaris (Dog) (Canis familiaris) AVADIHCENCK 1 9.2 0.98373 0.035491 0 10.5928 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJ21 A0A8I3MJ21_CANLF F-box and WD repeat domain containing 11 FBXW11 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] LQYDERVIVT;VIEDKTIELMNTSV 2 4.6 1.0043 -0.8172 10.1845 0 0 0 0 10.2974 0 0 0 0 0 0 0 0 0 A0A8I3MJ33 A0A8I3MJ33_CANLF Globin domain-containing protein HBQ1 Canis lupus familiaris (Dog) (Canis familiaris) hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ADALTTAVAHLD;AHGKKVADALTTAVAHLD;ALSALSDLHA;ALSALSDLHAYKL;ALTTAVAH;ALTTAVAHL;ALTTAVAHLD;ALTTAVAHLDDLPG;ALTTAVAHLDDLPGAL;AVAHLDDLPGAL;DALTTAVAHL;DALTTAVAHLD;DKFFTAVSTVLTSKY;DKFFTAVSTVLTSKYR;DKIGGHAGDYG;DKIGGHAGDYGGEAL;DLPGALSALSDLHAYKL;DLPGALSALSDLHAYKLRVD;DPVNFKLL;DRTFQSFPTTKTYFPHF;DRTFQSFPTTKTYFPHFDLSPG;DRTFQSFPTTKTYFPHFDLSPGSA;EALDRTFQ;FDLSPGSAQV;FFTAVSTVLTSKY;FPHFDLSPG;FPHFDLSPGSA;FPHFDLSPGSAQV;FPTTKTYFPHFD;FPTTKTYFPHFDLSPGSAQV;FTAVSTVLTSKY;FTAVSTVLTSKYR;GEALDRTF;GEALDRTFQ;GEALDRTFQSF;GGEALDRTFQ;GGEALDRTFQSF;GHAGDYGGEAL;GHAGDYGGEALD;GHAGDYGGEALDRTFQ;HAGDYGGEAL;HAGDYGGEALD;HFDLSPGSA;HFDLSPGSAQV;IGGHAGDYGGEALD;KIGGHAGDYGGEALD;KKVADALTT;LPGALSALSDLHAYKLRVD;LSPADKTNIK;LSPADKTNIKS;LSPADKTNIKST;LTTAVAHLD;PADKTNIK;PADKTNIKST;PHFDLSPGSAQV;PTTKTYFPHFDLSPGSAQV;PVNFKLLSH;RTFQSFPTT;RTFQSFPTTKTYFPHFDLSPGSAQV;SALSDLHA;SALSDLHAYKLRVD;SDLHAYKLRVD;SFPTTKTYFPHFDLSPG;SFPTTKTYFPHFDLSPGSAQV;SLDKFFTAV;SLDKFFTAVST;SPADKTNIK;SPADKTNIKS;SPADKTNIKST;SPADKTNIKSTWDK;SPADKTNIKSTWDKIG;SPADKTNIKSTWDKIGG;SPADKTNIKSTWDKIGGHA;TAVSTVLTSKY;TAVSTVLTSKYR;TFQSFPTTKTYFPHFD;TPAVHASLDKFFTAVSTVLTSKYR;TTAVAHLD;TTAVAHLDDLPG;TTKTYFPHFDLSPGSAQV;TYFPHFDL;TYFPHFDLSPG;TYFPHFDLSPGSAQV;VAHLDDLPGAL;VDPVNFKLL;VLSPADKT;VLSPADKTN;VLSPADKTNI;VLSPADKTNIK;VLSPADKTNIKS;VLSPADKTNIKST;VLSPADKTNIKSTW;VLSPADKTNIKSTWD;VLSPADKTNIKSTWDK;VLSPADKTNIKSTWDKIG;VLSPADKTNIKSTWDKIGG;VLSPADKTNIKSTWDKIGGH;VLSPADKTNIKSTWDKIGGHA;VLSPADKTNIKSTWDKIGGHAG;VLSPADKTNIKSTWDKIGGHAGD;VLSPADKTNIKSTWDKIGGHAGDY;VLSPADKTNIKSTWDKIGGHAGDYG;VSTVLTSKY;VSTVLTSKYR;YFPHFDLSPGSAQV;YGGEALDRTF 106 88.7 0 175.51 16.1543 16.2754 16.05 17.6313 17.9814 18.092 18.1023 18.1555 18.2497 16.3135 16.0911 15.8744 16.0825 16.3552 16.202 A0A8I3MJ60 A0A8I3MJ60_CANLF Glycolipid transfer protein domain containing 2 GLTPD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid transfer activity [GO:0120013] AGTLGDVYNR;VLLLLLLYVWAWSLQV 2 8.8 0.98353 -0.25662 8.06975 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJ61 A0A8I3MJ61_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP43 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] GDGDGDGD;GPWPSWKQPACL;HDSHPLCHWAVDRAMHLRRPGGPPH;LRLPRKAGRPAWA;TDLLAEFLA;VGLAVPILSTVAALRK;VHEDLEGSSRGP 7 8.7 0.72886 0.24793 0 4.77321 0 5.14975 0 9.94895 6.02099 0 8.2811 0 0 9.01248 0 0 0 A0A8I3MJ75 A0A8I3MJ75_CANLF NLR family pyrin domain containing 1 NLRP1 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to UV-B [GO:0071493]; neuron apoptotic process [GO:0051402]; NLRP1 inflammasome complex assembly [GO:1904784]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; protein homooligomerization [GO:0051260]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981]; self proteolysis [GO:0097264] NLRP1 inflammasome complex [GO:0072558]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; cysteine-type endopeptidase activator activity [GO:0140608]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; molecular condensate scaffold activity [GO:0140693]; pattern recognition receptor activity [GO:0038187]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; signaling adaptor activity [GO:0035591] AEAGLMSA;ELCYRSPREPQ;IHKPPPLA;LGSGIRLQ;SPIGVLLRTIHAALRFLP;TPSQMRKLFSFSR;VAQYGEQQ;VDTSLFYAAH;VLSEEQYERVRAE;WNEDPSSCKYQEGLPDSPE;YHLAHRCLQEFF 11 8.9 0.997 -4.1802 0 0 10.2281 0 0 0 8.42408 9.27396 14.4184 9.57658 0 0 9.35328 0 0 A0A8I3MJ81 A0A8I3MJ81_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP4C Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; regulation of double-strand break repair via homologous recombination [GO:0010569] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein phosphatase 4 complex [GO:0030289] protein serine/threonine phosphatase activity [GO:0004722] EILVEESNVQRVDSPVTVCGDIHGQ;GVSPRGAGYLFGS;QETRGIPS;VETFLLLLALKV 4 18.9 1.0033 -1.6438 0 0 0 0 0 0 0 0 8.24669 0 0 0 0 0 3.75189 A0A8I3MJ90 A0A8I3MJ90_CANLF Dehydrogenase/reductase SDR family member 7C (Short-chain dehydrogenase/reductase family 32C member 2) DHRS7C Canis lupus familiaris (Dog) (Canis familiaris) glucose import [GO:0046323]; intracellular calcium ion homeostasis [GO:0006874]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] longitudinal sarcoplasmic reticulum [GO:0014801]; sarcoplasmic reticulum membrane [GO:0033017] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745] EFFFAVVACGVKE;VLMLPLLLLGISGLLFIYQ 2 10.3 0.91379 0.10922 6.16822 0 0 0 0 0 0 0 0 0 0 0 8.19623 0 0 A0A8I3MJA7 A0A8I3MJA7_CANLF Sin3A associated protein 25 SAP25 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] PSFWPLYEAASGRDLSPLA;SSCCCAPG 2 14 1.0033 -1.1044 4.5544 0 5.09453 0 0 0 0 0 0 0 5.23385 0 4.53674 0 0 A0A8I3MJB0 A0A8I3MJB0_CANLF Zonadhesin ZAN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDEDKECPKNTTNPSSCNSGF;IIPTEKTSVPTERP;LAHCGCTNNGV;LCEPLSCRAGEICTLG;LHMDSNTFHRGGV;LTEKTTILTEKLTPTI;NLTRGCFRESPCL;PHLGSVCVSLQASCL;PSTTAPSTSMTT;TKKKHPSLLWK;VGPTVLVMPS;VLTERSTVTTERP 12 5.4 0.99128 -0.22139 0 0 0 0 9.91371 0 8.91349 10.4574 0 0 0 0 0 0 0 A0A8I3MJC1 A0A8I3MJC1_CANLF Low density lipoprotein receptor class A domain containing 2 LDLRAD2 Canis lupus familiaris (Dog) (Canis familiaris) LGSCGAYFRCQN 1 4.3 0.99218 -0.17657 0 0 0 8.84518 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJC4 A0A8I3MJC4_CANLF Lysosomal trafficking regulator LYST Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; natural killer cell mediated cytotoxicity [GO:0042267]; pigmentation [GO:0043473] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630] AGFGDCCNLSD;AVVQRVEAREEEEE;DNILRLKSKQS;ESDIIMSP;ETLQGNSCDAESSPN;ILTQADSDFQACQRVLVDL;LDQLGGAEKPQKIK;LEGCCDED;LQHFVTQSPKEDHL;MPPCLSPE;NSGTVLHFLVRMPPFTKM;QELLECFIEMFFGRR;QENIFVPSKWQH;SMIHQVLIKQKC;SPVTAVSAS;VDTYKYLEEEYRK;VLCNTVAALN;VLLVGILKII 18 5.8 0.99649 -4.9577 4.26739 9.68317 5.15579 6.49934 7.66796 0 7.36912 11.9103 12.5398 6.42866 5.10278 8.62742 10.3971 0 8.56426 A0A8I3MJE0 A0A8I3MJE0_CANLF RNA methyltransferase (EC 2.1.1.-) MEPCE Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA modification [GO:0040031] 7SK snRNP [GO:0120259] 7SK snRNA binding [GO:0097322]; RNA 5'-gamma-phosphate methyltransferase activity [GO:1990276] LDEEVSRALNAETPKS;PPGGGGGK;VGKESPGATSTRGGQSQQQ 3 6.2 0.99214 -0.16727 0 0 0 0 0 10.0593 6.07133 0 0 9.72746 0 0 11.0798 6.80787 0 A0A8I3MJF1 A0A8I3MJF1_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUB2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] HYNILYAADKR;MDTALNHHVFPEA;WIQAPAGL;YVDEMDTALNH 4 10.4 1.0026 -1.1451 0 0 0 0 0 0 6.68958 0 9.5256 0 7.93304 0 0 0 0 A0A8I3MJG2 A0A8I3MJG2_CANLF Centromere protein F CENPF Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, centromeric region [GO:0000775]" dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] AFQETMLRDLQD;DLELDLVHIRSEKENMIKE;ELDLVHIRSEKENM;ELEKMCEML;ENMCLKISELTGQVEDLEHKL;EQGSMPSERSKCHLEA;ESERKADALQDKIENLERE;ETSQRISKLQEDS;KQKLKKKDEEIN;KQMNSDLQKQCQ;KQYLSENEQWQQKL;KTAVGMLQTQ;LKKREHHIE;LSSDVTQLL;NTMSEEINSSRGQLKELMLE;QEQNLRSQVDAL;TEGANLKRENQSL;TRLQEQLQSLEKDSQAL 18 7.8 1.003 -1.9288 9.13389 0 12.0778 0 3.83673 0 0 10.2701 8.55773 10.0654 8.56487 10.5994 9.51027 8.71067 7.4143 A0A8I3MJG5 A0A8I3MJG5_CANLF Polycomb group ring finger 3 PCGF3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] PRC1 complex [GO:0035102] metal ion binding [GO:0046872] KDHTLKFVVVTRWRFKKA;NGETKADDSSNKEAAE;RNGETKADDSSNK 3 14.5 0.97101 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 8.91073 0 A0A8I3MJH2 A0A8I3MJH2_CANLF Atonal bHLH transcription factor 7 ATOH7 Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; neural retina development [GO:0003407]; optic nerve development [GO:0021554]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to auditory stimulus [GO:0010996] axon [GO:0030424]; nucleus [GO:0005634]; perikaryon [GO:0043204] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" GGAQCAGA 1 5.3 1.0041 -1.1044 6.19985 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJI5 A0A8I3MJI5_CANLF Pre-mRNA-splicing factor SLU7 SLU7 Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]" catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; small nuclear ribonucleoprotein complex [GO:0030532] pre-mRNA 3'-splice site binding [GO:0030628]; second spliceosomal transesterification activity [GO:0000386]; zinc ion binding [GO:0008270] AVDAVNAAPLSGS;AVNAAPLSGSKEM;DEHVQPQLMFD;EEKKKKKKKKKKHR;KKKKKKKK;KKKKKKKKKKH 6 6.5 0.99115 0.0022612 0 0 5.6253 9.08531 0 0 0 0 9.1408 9.96116 0 0 0 0 0 A0A8I3MJK1 A0A8I3MJK1_CANLF FXYD domain-containing ion transport regulator Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transmembrane transport [GO:0071805]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] ion channel regulator activity [GO:0099106] MPQGEVHIQPWVSIPTQAL 1 16.4 0.95301 0.049489 0 0 0 0 0 0 6.4154 0 0 0 0 0 0 0 0 A0A8I3MJL1 A0A8I3MJL1_CANLF Natural cytotoxicity triggering receptor 1 (Natural killer cell p46-related protein) NCR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] KLLVTETNTISFSPY 1 4.7 0.94981 0.053889 0 0 0 7.44783 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJL3 A0A8I3MJL3_CANLF Acyl carrier protein NDUFAB1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I [GO:0005747] acyl binding [GO:0000035]; acyl carrier activity [GO:0000036] VRRLPAALAPLPRVPT 1 10.4 0.99562 -0.15369 17.0508 0 0 8.97447 8.61919 10.8678 0 0 0 0 5.50408 0 0 5.85464 0 A0A8I3MJM5 A0A8I3MJM5_CANLF Solute carrier family 25 member 46 SLC25A46 Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; mitochondrial membrane fission [GO:0090149] mitochondrial outer membrane [GO:0005741] AASLCSDVILYPLE;HYHLTPFT;LHGVLHYIIS;LILKRKTY;THWVTSPPD 5 11.8 0.98841 -0.2605 0 5.90797 0 10.483 0 0 5.64178 5.47868 0 0 5.15955 0 0 5.94118 0 A0A8I3MJN4 A0A8I3MJN4_CANLF Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) PIK3C3 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; endocytosis [GO:0006897]; phosphatidylinositol-mediated signaling [GO:0048015] "endosome [GO:0005768]; peroxisome [GO:0005777]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524] LDINVQLKIWN;VELIPLPL 2 2.3 1.0037 -1.0689 0 8.144 0 0 0 0 0 0 0 0 4.48536 4.00009 0 0 0 A0A8I3MJP6 A0A8I3MJP6_CANLF Interleukin 2 receptor subunit alpha IL2RA Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911] MQSQTPPMDEVDLVDDEELQAS;NRKGKVTTK 2 15.8 0.9894 -0.51029 0 0 9.91416 0 0 10.2564 0 0 12.9734 12.6257 0 0 3.2093 0 0 A0A8I3MJQ1 A0A8I3MJQ1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MUL1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] mitochondrial outer membrane [GO:0005741] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] GVEQPAQRGAGH;LEVAEGRQ;LRARVRVLLLVLLLDAA;QEHEAQLLSRAKPEDRE;VIGHYISGERPK;VWNRTTHLWNDYSKIIHQ 6 14.9 1.0026 -1.1891 9.18269 0 0 0 0 7.70127 12.3012 0 0 4.3168 6.20038 0 9.19042 0 0 A0A8I3MJQ4 A0A8I3MJQ4_CANLF KIAA2013 KIAA2013 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPASASGLAP 1 1.7 0.99964 -0.61146 0 6.54347 12.9853 11.2109 11.3561 11.4183 0 0 0 13.2034 13.2539 13.275 13.4206 13.4172 13.3025 A0A8I3MJR1 A0A8I3MJR1_CANLF Uncharacterized protein GOLPH3 Canis lupus familiaris (Dog) (Canis familiaris) "Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] phosphatidylinositol-4-phosphate binding [GO:0070273] DREGYTSFWND;GGGGGGGE 2 6.4 0.98851 0.035491 0 0 0 0 0 0 0 0 0 7.13381 0 0 0 0 0 A0A8I3MJR7 A0A8I3MJR7_CANLF Lines homolog 1 LINS1 Canis lupus familiaris (Dog) (Canis familiaris) FGGDEVQPACECVHGP;SLGIYLKLT;VKRKFIIFIKKCLLWKVG 3 5.8 0.98555 -0.23597 9.37389 7.83422 0 0 0 0 8.89108 0 4.41393 0 0 0 0 0 0 A0A8I3MJT8 A0A8I3MJT8_CANLF T-box transcription factor 19 SFT2D2 Canis lupus familiaris (Dog) (Canis familiaris) cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ISSPTKAYNV;LSVPHTSG;NSGGGPAG;SNSGGGPAG 4 4.7 1.0031 -1.7228 0 0 0 0 0 0 0 0 0 10.1392 12.1549 7.1812 0 0 0 A0A8I3MJU0 A0A8I3MJU0_CANLF Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein) CRYM Canis lupus familiaris (Dog) (Canis familiaris) thyroid hormone metabolic process [GO:0042403] mitochondrion [GO:0005739]; nucleus [GO:0005634] hormone binding [GO:0042562] AYSHYEVFTEQFFFKEVR 1 5.7 0.97615 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.02326 0 0 A0A8I3MJU5 A0A8I3MJU5_CANLF "WASP homolog associated with actin, golgi membranes and microtubules" WHAMM Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; small GTPase binding [GO:0031267] DALFPADGGAPDCE;DLFAEPERHQLRFLVAWNDAEGK;EEGEGEGEDGDEQS;GVKLKKVHSGPGLSP;VATLCKLDI 5 9 1.0022 -1.2016 9.82917 0 0 0 0 7.84844 0 9.39157 0 0 0 0 0 10.6406 0 A0A8I3MJU8 A0A8I3MJU8_CANLF Regulator of G protein signaling 17 RGS17 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] APGNQRPNNTCCFCWCCCCSCSC;CCCCSCSCLT;CCFCWCCCC;CCFCWCCCCSC;CCFCWCCCCSCSC;CCFCWCCCCSCSCL;CCFCWCCCCSCSCLTV;CFCWCCCCSCS;CFCWCCCCSCSCL;CFCWCCCCSCSCLTV;CWCCCCSCSC;CWCCCCSCSCLT;CWCCCCSCSCLTV;ENAGRPTH;FCWCCCCSCSCL;NNTCCFCWCCCCS;NNTCCFCWCCCCSCSC;NTCCFCWCCC;NTCCFCWCCCC;NTCCFCWCCCCS;NTCCFCWCCCCSCSC;NTCCFCWCCCCSCSCL;NTCCFCWCCCCSCSCLTV;PGNQRPNNTCCFCWCCC;QRPNNTCCFCWCCCCSCSCL;TCCFCWCCCCSC;TCCFCWCCCCSCSC;TCCFCWCCCCSCSCLT 28 16.2 0.99539 -0.56432 10.0129 3.70752 0 5.74994 7.85854 8.08821 0 0 8.31701 0 6.88521 0 8.56201 7.6241 5.80462 A0A8I3MJV2 A0A8I3MJV2_CANLF Serine/threonine/tyrosine interacting protein STYX Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] F-box domain binding [GO:1990444] EANFVKPNFQQLFRYLV;EFPSLPQCKEDA;ERRFCINPNAGFV;GMKYRDAFAYVQERRFCI;SLKRTHEEEEDFGNMQ 5 34.1 1.0008 -0.93178 0 0 9.68373 0 0 0 0 0 10.5341 9.30524 0 0 9.71937 0 0 A0A8I3MJV6 A0A8I3MJV6_CANLF G0/G1 switch 2 G0S2 Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway [GO:0097191]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238] mitochondrion [GO:0005739] QELVARRPGRKLV 1 13.7 0.94356 0.059627 5.8489 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJW4 A0A8I3MJW4_CANLF Zinc finger protein 470 ZNF470 Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FSHGSSLTVHQRIH;LVSEKTHFSQETVTHIDNLI 2 4.7 0.98905 -0.22652 0 0 9.5683 0 0 0 12.5945 8.01959 0 0 0 0 0 0 0 A0A8I3MJX0 A0A8I3MJX0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ILRKLVPKNLGPKKPVV;LVPKNLGPKKPVVTFQAHDGPVYS 2 8.6 0.9417 0.087529 0 0 0 0 4.32582 0 0 0 0 0 0 0 0 8.43237 0 A0A8I3MJX2 A0A8I3MJX2_CANLF Zinc finger protein 365 ZNF365 Canis lupus familiaris (Dog) (Canis familiaris) ELLRKEEEVVTFNHF;HVRPALLLLL;LSLGTYSPPWASA 3 10.2 0.98992 -0.26217 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6252 A0A8I3MJX7 A0A8I3MJX7_CANLF Leucine rich repeat and fibronectin type III domain containing 5 LRFN5 Canis lupus familiaris (Dog) (Canis familiaris) SSTAFDDV 1 1.1 1.0036 -1.1044 0 0 0 0 0 0 0 7.783 8.08709 0 0 0 0 0 0 A0A8I3MJY0 A0A8I3MJY0_CANLF Ribitol-5-phosphate transferase FKRP Canis lupus familiaris (Dog) (Canis familiaris) adult walking behavior [GO:0007628]; basement membrane organization [GO:0071711]; bone mineralization [GO:0030282]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; connective tissue development [GO:0061448]; connective tissue replacement [GO:0097709]; creatine metabolic process [GO:0006600]; diaphragm development [GO:0060539]; filtration diaphragm assembly [GO:0036058]; glial cell differentiation [GO:0010001]; glycolytic process [GO:0006096]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; localization of cell [GO:0051674]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; muscle contraction [GO:0006936]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; oxygen metabolic process [GO:0072592]; pentitol metabolic process [GO:0019519]; pentose metabolic process [GO:0019321]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; protein import [GO:0017038]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485]; protein tetramerization [GO:0051262]; reelin-mediated signaling pathway [GO:0038026]; reproductive process [GO:0022414]; respiratory system process [GO:0003016]; response to activity [GO:0014823]; response to alcohol [GO:0097305]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue regeneration [GO:0043403] cytosol [GO:0005829]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum [GO:0005791]; sarcolemma [GO:0042383]; skeletal muscle myofibril [GO:0098723] "dystroglycan binding [GO:0002162]; identical protein binding [GO:0042802]; laminin binding [GO:0043236]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" AASRPETYVAT;FYVSWLQHQPRNSRARGP;LRAGGARL 3 7.5 1.0024 -0.76281 5.37027 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MJZ9 A0A8I3MJZ9_CANLF Ig-like domain-containing protein LOC119875990 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSFPEWLHQVTF 1 4.3 0.95487 0.05044 0 0 0 0 0 0 0 8.74665 0 0 0 0 0 0 0 A0A8I3MK02 A0A8I3MK02_CANLF Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) DNASE1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; zymogen granule [GO:0042588] actin binding [GO:0003779]; DNA nuclease activity [GO:0004536] CPQILSRYDVA;ISDHYPVEVT;VLDSYQYDDGCEPCGNDT 3 11.1 0.98977 -0.52765 0 0 0 0 5.55105 7.73586 0 0 0 0 0 0 9.23487 0 9.84978 A0A8I3MK06 A0A8I3MK06_CANLF Uncharacterized protein LOC488951 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HQKIQILEQHFEYSE;SFCVKSKL;VGFTQEEWQHLNL;YNKNGNDHLNEDFVHH 4 9.1 1.0032 -1.5507 10.0888 0 0 7.72397 0 0 9.84175 9.50379 0 0 0 0 0 0 0 A0A8I3MK22 A0A8I3MK22_CANLF Ras homolog family member H RHOH Canis lupus familiaris (Dog) (Canis familiaris) mast cell activation [GO:0045576]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of T cell differentiation [GO:0045582]; small GTPase-mediated signal transduction [GO:0007264]; T cell differentiation [GO:0030217] cytoplasm [GO:0005737]; immunological synapse [GO:0001772] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase inhibitor activity [GO:0019210] VLVGDSAVGKTSL 1 6.8 0.93912 0.062472 0 0 8.50641 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MK46 A0A8I3MK46_CANLF Mannosyltransferase (EC 2.4.1.-) ALG9 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] LKPRKAKQIRK;QNLGHPYWLTL;YPEFYRIATDPTI;YTVYANYTILKPRKAKQIRKKSG 4 7.6 0.98967 -0.51695 0 0 0 0 0 0 0 0 10.442 0 0 0 0 0 5.81496 A0A8I3MK47 A0A8I3MK47_CANLF General transcription factor IIi LOC607692 Canis lupus familiaris (Dog) (Canis familiaris) transition between fast and slow fiber [GO:0014883] nucleus [GO:0005634] ELPMEDSTQRVPSET;GVDENFDVSEELL;VHCAKILSMFGSTYI 3 4.5 0.98906 -0.52392 0 0 0 0 0 0 0 0 0 5.6006 0 0 0 0 0 A0A8I3MK52 A0A8I3MK52_CANLF isopentenyl-diphosphate Delta-isomerase (EC 5.3.3.2) IDI1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isoprenoid biosynthetic process [GO:0008299] peroxisome [GO:0005777] isopentenyl-diphosphate delta-isomerase activity [GO:0004452] EINYLTRIHYKAQ;LDELDAQQVQLLAE;PMEEVPPEEINYLTR;PPEEINYLT 4 15.4 1.0032 -0.78949 13.7027 0 0 0 0 0 0 0 8.7939 8.55447 0 0 8.40092 0 8.04903 A0A8I3MK53 A0A8I3MK53_CANLF Cytochrome P450 (EC 1.14.14.1) LOC484492 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" ADIDITPRVSGFGNIPPTYE;EEAGFLLEELRKT;HQDTNNPHTEFNL;IDQVIGPHRIPSVDD;TDATFQSFMKLREKYGPIFTVYMG 5 17.2 0.98649 -0.39169 0 0 9.59939 0 0 0 0 7.09233 0 0 0 9.33689 0 0 0 A0A8I3MK55 A0A8I3MK55_CANLF Uncharacterized protein LOC608120 Canis lupus familiaris (Dog) (Canis familiaris) AAVGRLRP;EERGRLWEVEPPGAWGQRGSI 2 7.8 1.0016 -1.3138 10.4728 0 0 0 0 0 0 0 0 0 5.54294 0 0 0 0 A0A8I3MK58 A0A8I3MK58_CANLF hexokinase (EC 2.7.1.1) HKDC1 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] mitochondrion [GO:0005739]; photoreceptor inner segment [GO:0001917] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; glucokinase activity [GO:0004340] DFLDYMGLKGVQ;DKTGSNMCYMEEMRN;EPSEADCI;IVQCIADFLDYMGLK;NEIIRGNGSEL 5 6.1 0.95125 0.053874 0 0 0 0 0 6.19564 0 0 0 0 0 0 0 0 0 A0A8I3MK65 A0A8I3MK65_CANLF Dynein light chain Tctex-type 1 DYNLT1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868] dynein intermediate chain binding [GO:0045505] EWLLYIGFVL 1 4.8 0.99825 -0.61146 0 7.49937 0 0 0 0 0 6.25901 0 0 0 0 7.26313 0 0 A0A8I3MK67 A0A8I3MK67_CANLF Protein S100-A4 (Metastasin) (S100 calcium-binding protein A4) S100A3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; RAGE receptor binding [GO:0050786]; transition metal ion binding [GO:0046914] LSCVAMMCNEFFEGFPDK;NEVDFQEYCVF;PGRGRMGQGGAAVVAGSTGGAV 3 23.4 0.9743 0.048094 0 0 0 0 0 0 0 0 0 0 0 0 9.79666 0 0 A0A8I3MK71 A0A8I3MK71_CANLF Transient receptor ion channel domain-containing protein TRPC6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium channel activity [GO:0005262] AKQNEAFTTVEESFKTLFWAIFGLS;FNLYSYYIGAKQNEAF;LLPNETSTDN;LLPNETSTDNARQLFRMKTSCFSW;PSPKSLFYLLLRLKKWIS;YLSLSSEDPVMTALEL 6 11.3 1.0026 -0.8971 0 0 7.64155 0 0 0 10.5372 10.1237 0 10.5731 0 0 8.87535 9.16486 0 A0A8I3MK74 A0A8I3MK74_CANLF Transmembrane protein 157 FAM174A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGGNGSSP;LLLLLLLP;PLEQDDEDDDN 3 14.2 1.0038 -1.0689 5.74233 0 0 0 0 0 0 0 0 0 0 0 0 8.51313 0 A0A8I3MK79 A0A8I3MK79_CANLF Vasorin VASN Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] cell surface [GO:0009986]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886] transforming growth factor beta binding [GO:0050431] LECLCPEF;LHDLDVSDN;PAPTWLAPTEPATEAPSL;TVFCTARQGTTV 4 7 1.0024 -0.71563 0 0 0 7.4154 0 0 11.0344 0 0 10.1043 0 0 0 6.81301 6.71987 A0A8I3MK88 A0A8I3MK88_CANLF Family with sequence similarity 200 member B FAM200B Canis lupus familiaris (Dog) (Canis familiaris) ESELLQLSSSYTLKSD;YYMFPRFLQ 2 3.8 1.0039 -1.0389 8.67835 0 0 0 5.64521 0 0 0 0 0 0 0 8.19421 0 0 A0A8I3MK93 A0A8I3MK93_CANLF Dermatan sulfate epimerase like DSEL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sulfotransferase activity [GO:0008146] AEYIRALRRHLV;AVFTDDIDQFKTQK;ICAKWARTEAEASLKSLSSEG;LSPASLNQILFA;NNVLVFAPSPTSQ;RFYLSFRKLMRWILILVIALWFIE;SPASLNQILFA;VGYKDWLVENAPGDEVP 8 9.3 1.0013 -0.70235 0 13.8986 0 0 0 0 0 7.5205 0 0 0 12.231 9.63954 8.66956 12.4302 A0A8I3MKA1 A0A8I3MKA1_CANLF PDZ domain containing 2 PDZD2 Canis lupus familiaris (Dog) (Canis familiaris) DDASDEEEFDGEG;DLTDGADDP;EDQEPDGEEDGS;FDAWNIMKSVPEG;LSCPVRPAAGACPAGSGPK;LSGPSRPLTE;LSIPNASQ;LSSMYGDAEDSSSD;MGIFVKTIFPNGSAAE;RVYKGGAA;SIPNASQPFSVLDVSS;VGCYDTDDASD;VGCYDTDDASDEEEFDGEGD;VGCYDTDDASDEEEFDGEGDCI;VGCYDTDDASDEEEFDGEGDCIS;VINGHLLVGL;VLSSVGSKSTV;YHSEQNYESTSFFSVK 18 6.4 0.99741 -3.4225 0 9.14349 9.20552 10.533 8.43825 9.43342 0 5.10043 0 0 14.5489 0 6.88448 3.6646 11.2659 A0A8I3MKB3 A0A8I3MKB3_CANLF CYRIA/CYRIB Rac1 binding domain-containing protein CYFIP2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell projection assembly [GO:0030031]; regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; synapse [GO:0045202] small GTPase binding [GO:0031267] ETKEPSMMEYV;FGDGLNWAGCSI;KTDVFQSLREVG;MYFQRKAIE;QIFAYYKAMAGS;VGRPGSPSPQPFPALCVTAA 6 5.3 0.98507 -0.23628 0 0 0 0 0 11.4793 0 0 0 0 0 0 0 0 0 A0A8I3MKB9 A0A8I3MKB9_CANLF CDC42 effector protein 5 CDC42EP5 Canis lupus familiaris (Dog) (Canis familiaris) JNK cascade [GO:0007254]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of pseudopodium assembly [GO:0031274]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] GPSMLDAVLGVMDAERP;TSFLSRHGGGP 2 18.3 0.98898 -0.21483 0 0 0 0 0 4.88455 0 0 0 0 0 0 7.41937 0 0 A0A8I3MKD0 A0A8I3MKD0_CANLF Ligand dependent nuclear receptor corepressor like LCORL Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677] CSGPVTHSSVDSYFLH;EDCEPEELTDWSMDE;KDNKQPRKKRGRYRQYD;LEYKVKERSGT;LSSQGQSNTEKIE;SFCNLQREAV 6 13.7 0.99025 -0.20171 0 0 0 0 0 0 8.24536 0 4.79732 0 0 0 0 0 0 A0A8I3MKE6 A0A8I3MKE6_CANLF Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) SCNN1G Canis lupus familiaris (Dog) (Canis familiaris) cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; sensory perception of taste [GO:0050909]; sodium ion import across plasma membrane [GO:0098719] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; sodium channel complex [GO:0034706] ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699] EKIKAKIKKNLPVRGPQA;YCNYQQHPNWMYCYYELHQAF 2 6 0.92624 0.095479 0 0 0 0 0 0 0 10.1412 0 0 0 0 0 0 0 A0A8I3MKE7 A0A8I3MKE7_CANLF F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) FBXL5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]; positive regulation of protein catabolic process [GO:0045732]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005] iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] DEDADIDESEES;SDQETGRVLLFLSLSGCYQITD 2 4.9 0.99667 -0.57518 0 10.2503 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKG4 A0A8I3MKG4_CANLF Radial spoke head 3 RSPH3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; motile cilium [GO:0031514] LTQPAEEPIHY;VELAEVQRLEEQER;VLVGKTIEQSL;WLMNEVDKTMEYNMV;YAYEELRNVELAEVQRLEE 5 18.4 0.99794 -0.098375 0 0 5.24857 0 0 0 0 0 9.04865 0 0 6.61803 0 0 0 A0A8I3MKG8 A0A8I3MKG8_CANLF Uncharacterized protein SRRM2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] mRNA binding [GO:0003729] DEELMEVVEKSE;ESPKPAPAPGSRREISS;QKKKKKKK;SLTGSGTPPTAANY;SPTPKQKKKKKKKDRGR;SSKKKKHRSES;STPPGELYFAASSLQQK;TPPRQSHSGSTSPCPKV;VKPQTPSGHSLSE;WSGPHFSPEHK 10 5 1.0032 -1.582 0 11.1099 0 0 0 10.7142 11.7675 0 13.7942 9.15601 0 0 9.00963 0 0 A0A8I3MKH9 A0A8I3MKH9_CANLF Solute carrier family 4 member 9 SLC4A9 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] EVTVLPPGLWDPTTR;VLAMLLGCGLDSFLG 2 3.4 0.8815 0.1315 8.488 0 0 0 0 0 0 0 0 0 0 0 8.80158 0 0 A0A8I3MKI5 A0A8I3MKI5_CANLF Zinc finger protein 367 ZNF367 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAEHPGLR 1 2.3 1.0039 -1.1044 0 0 0 0 0 0 9.01995 0 0 0 0 0 0 0 0 A0A8I3MKK0 A0A8I3MKK0_CANLF Uncharacterized protein ZNF286A Canis lupus familiaris (Dog) (Canis familiaris) SPNLTTTIWRME 1 20 0.9533 0.05044 0 9.2999 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKK1 A0A8I3MKK1_CANLF POU domain protein POU2F1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LVHPTTNLQPA 1 1.6 0.9895 -0.21762 0 0 0 9.43066 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKK2 A0A8I3MKK2_CANLF Protein tweety homolog TTYH1 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868] intracellularly calcium-gated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320] VTEGNFHQLVALVH 1 3.1 0.94127 0.061052 0 0 0 0 0 0 0 0 0 0 8.97785 0 0 0 0 A0A8I3MKK5 A0A8I3MKK5_CANLF MICOS complex subunit Canis lupus familiaris (Dog) (Canis familiaris) cristae formation [GO:0042407] MICOS complex [GO:0061617] GGSKIKKL;VQWGGSKIKKL 2 7.1 0.9957 -0.56774 0 0 0 0 9.99421 0 0 0 0 0 0 0 0 0 0 A0A8I3MKK8 A0A8I3MKK8_CANLF DDHD domain containing 1 DDHD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; phospholipase activity [GO:0004620] AGHEPEMEELV;DIMTGWNPVRLYEQLLQKEEELPDE;EEDDDDDDG;GGGGGGGG;GPASSSGGEEEEDDDDDDGD;MYKHEHDSNAKPN;PSFLHPAK 7 10.4 1.0026 -0.75601 0 3.99141 0 0 4.80245 0 0 0 0 0 0 0 0 0 0 A0A8I3MKL2 A0A8I3MKL2_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) RNF146 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] GAWAGPGRDPGSTSGP;TAPSLTVPECAI 2 6.3 0.98665 -0.32287 0 0 9.86648 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKL4 A0A8I3MKL4_CANLF NF-kappa-B inhibitor alpha (I-kappa-B-alpha) NFKBIA Canis lupus familiaris (Dog) (Canis familiaris) B cell receptor signaling pathway [GO:0050853]; canonical NF-kappaB signal transduction [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of Notch signaling pathway [GO:0045746]; non-canonical NF-kappaB signal transduction [GO:0038061]; Notch signaling pathway [GO:0007219]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of cell population proliferation [GO:0042127]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; nuclear localization sequence binding [GO:0008139]; protein sequestering activity [GO:0140311]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin protein ligase binding [GO:0031625] YQGYSPYQLTWGRP 1 4.5 0.94032 0.061072 0 0 0 0 4.16342 0 0 0 0 0 0 0 0 0 0 A0A8I3MKN5 A0A8I3MKN5_CANLF Protein S100 (S100 calcium-binding protein) S100A12 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] KLFQDLDADKDGQVNFN 1 18.5 0.98484 -0.24647 10.2484 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKP1 A0A8I3MKP1_CANLF Glycogen [starch] synthase (EC 2.4.1.11) GYS1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978]; heart development [GO:0007507] cytosol [GO:0005829]; inclusion body [GO:0016234] "glycogen (starch) synthase activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]" DVDGERYDEDE;EFLAQNEEKPHVVAHFHE;MERAAAHCAHVFTTVSQ;SFPPVCTHNMLDDSSDPILTTIRR 4 9.5 0.85741 0.17153 10.0868 0 0 0 6.15194 0 0 6.35027 0 0 0 0 5.90968 0 0 A0A8I3MKP3 A0A8I3MKP3_CANLF SET binding protein 1 SETBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nuclear body [GO:0016604] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800] DLSSEPADSC;FQPQAYERPQ;LKIQTTKRAKK;LLLGGVVPSPG;SEFLPVSSAKP;TKRYSGSGGD;YYAPYGMPYTSMPMM 7 4.9 0.99312 -0.28159 10.2228 10.2978 10.1226 0 0 0 0 10.0672 10.6239 0 0 14.2333 0 9.58637 10.0876 A0A8I3MKQ8 A0A8I3MKQ8_CANLF Multiple C2 and transmembrane domain containing 2 MCTP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIEVWGKDSRKHEER;EQESSNGILDLLQK;GVSVSDLCVCPLADPSE;KQRTRPLLINLSKKKVKK;NPEWNKVFTF;VYDRDLTTSDFMG 6 10.6 0.98425 -0.23921 0 0 0 0 0 10.1869 0 0 0 0 0 0 0 0 0 A0A8I3MKR5 A0A8I3MKR5_CANLF Heterochromatin protein 1-binding protein 3 HP1BP3 Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; nucleosome binding [GO:0031491] DDSRDEDEEEDDSSEEDSDDEEPP;EDEEEDDSSEEDSDDEEPP;LDDSRDEDEEEDD;SEETKKDEKD 4 6.3 0.98788 -0.46113 0 9.49005 0 6.27884 0 0 0 0 11.0486 0 0 0 0 0 7.21733 A0A8I3MKS5 A0A8I3MKS5_CANLF chitinase (EC 3.2.1.14) CHIA Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532] extracellular space [GO:0005615] chitin binding [GO:0008061]; chitinase activity [GO:0004568]; kinase binding [GO:0019900] GVTYQQNCQAGLVFDTSCDCCN 1 4.6 0.97695 0.047292 0 0 0 0 0 0 0 0 6.02425 0 0 0 0 0 0 A0A8I3MKU4 A0A8I3MKU4_CANLF Trafficking protein particle complex subunit 2-like protein TRAPPC2L Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008] EDYKMFRKLHNSYTD 1 13.8 0.93685 0.063703 0 6.38908 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKV0 A0A8I3MKV0_CANLF CENP-V/GFA domain-containing protein CENPV Canis lupus familiaris (Dog) (Canis familiaris) pericentric heterochromatin formation [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044] kinetochore [GO:0000776]; nucleus [GO:0005634]; spindle midzone [GO:0051233] carbon-sulfur lyase activity [GO:0016846]; metal ion binding [GO:0046872] ASLPDLGDQR;HKAQHTFCKRCGVQSF 2 10 0.99577 -0.56651 0 0 0 0 0 0 0 0 0 0 9.41153 0 0 0 0 A0A8I3MKV5 A0A8I3MKV5_CANLF Complexin 4 CPLX4 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; neurotransmitter transport [GO:0006836]; regulation of neurotransmitter secretion [GO:0046928] synapse [GO:0045202] syntaxin binding [GO:0019905] MVDEDQEEEEDKDSILGHL 1 11.9 0.95457 0.04941 0 0 0 0 0 0 0 4.53412 0 3.94645 0 0 0 0 0 A0A8I3MKW3 A0A8I3MKW3_CANLF Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) GAPDHS Canis lupus familiaris (Dog) (Canis familiaris) glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661] PLPQPKKAPVGQK;VESTGVYLSLEEASGHIEAGALRV;VGNPFVVESTGVY;YTEDEVVSTDFVGNTHSSIFD 4 15.8 0.80362 0.21888 0 0 0 6.92541 0 0 0 7.59984 8.24926 0 8.54423 0 0 0 0 A0A8I3MKW4 A0A8I3MKW4_CANLF Leucine rich repeats and calponin homology domain containing 4 LRCH4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAATTSVPGAPGLPGSR;GAPGLPGSRSAERALE;RDLSVRRN;SGDGDPEQIDFIDSHMPGEEEERG 4 8.7 0.99166 -0.29249 8.88243 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKW7 A0A8I3MKW7_CANLF Solute carrier family 35 member F2 SLC35F2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ASPAGPGA;ESSVPPITSIGIDN;VLMALSWFILY 3 8.9 0.983 -0.25565 0 15.0868 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MKX7 A0A8I3MKX7_CANLF Potassium voltage-gated channel modifier subfamily V member 2 KCNV2 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] FRDMRFYGPQRRRLWNLL;RDELCPRCFLEELGYW;VGKVGQVLRIMRLMRVLRILKLA;VGQVLRIMRLMRVLRIL;VGRVGKVGQVLRIMRLMRVLRILK;VLRIMRLMRVLRILKLAR 6 11.1 0.67219 0.27964 0 0 0 0 5.57383 0 0 9.80069 5.92222 4.96984 0 8.92582 0 6.83656 0 A0A8I3MKY3 A0A8I3MKY3_CANLF Cadherin domain-containing protein LOC487177 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEERFPRLR;GGWLRGARGPLSGPPGG;HRAGAAGGRG;QEDVPFTLKPSLENFYK;VGINNIQNYTIYP 5 8.7 1.0047 -1.0487 0 0 0 9.20486 0 0 6.64443 0 9.47784 0 0 0 0 8.85671 0 A0A8I3MKY8 A0A8I3MKY8_CANLF GSK3B interacting protein GSKIP Canis lupus familiaris (Dog) (Canis familiaris) regulation of canonical Wnt signaling pathway [GO:0060828] cytoplasm [GO:0005737] kinase regulator activity [GO:0019207]; protein kinase A binding [GO:0051018] DAELNGFE;ETVYSLLDTLSPAY;LDTLSPAYREAF 3 19 0.99197 -0.038527 0 0 0 0 0 9.98085 0 0 0 0 0 3.26698 0 0 9.32396 A0A8I3ML02 A0A8I3ML02_CANLF Pyruvate kinase (EC 2.7.1.40) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] LRVLKILRYKHMCLL 1 4.9 0.95092 0.053874 0 0 0 0 0 0 0 0 0 0 0 3.95671 0 0 0 A0A8I3ML07 A0A8I3ML07_CANLF FCF1 rRNA-processing protein Canis lupus familiaris (Dog) (Canis familiaris) DRLKPKKKEKKV;YHILVDTNFVNFSFFSFFFKFL 2 31.8 0.93258 0.098565 0 0 6.44877 0 0 0 0 0 0 0 0 4.74852 0 0 0 A0A8I3ML47 A0A8I3ML47_CANLF FYN binding protein 1 FYB1 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229] plasma membrane [GO:0005886] lipid binding [GO:0008289] DKPDKEPKPPFLK;FPAPPAELSQGAKAKTEEKDL;KEQEIKKK;NEENQDGVMHSD;PDDDIYDGIEEEDADDG;PPAELSQGAKAKTEE;QDDVSSHSQS;QEIKDHGGEASSSP;TDDTKVLCRNE;VLCRNEEGKYGYVLRSYLVDNDG;WSWGILKMLKGK 11 16.3 1.0032 -2.2858 0 0 0 9.58338 0 6.52394 0 0 0 0 7.88228 8.5159 0 4.50646 0 A0A8I3ML57 A0A8I3ML57_CANLF Transmembrane channel-like protein TMC4 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] ESISNLPQTVQ;GVAVMLLIQFPRKLL;HLAVTYLCSVFVI;PGVLPWGASEEEEEDGE;TAKFLLLFY 5 8.8 1.0031 -0.8717 0 0 0 0 0 6.72629 0 0 13.1441 0 0 0 9.65789 0 0 A0A8I3ML61 A0A8I3ML61_CANLF RRM domain-containing protein LOC100688858 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] RNA binding [GO:0003723] DLGPPVDPYEDSDN;GQQPALPHAVTAPPSYPPTSYSS 2 6.7 0.99093 -0.13522 0 0 0 0 0 0 0 0 0 0 10.1352 0 0 12.809 0 A0A8I3ML75 A0A8I3ML75_CANLF "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (Keratin-8) (Type-II keratin Kb8)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; keratin filament [GO:0045095]; nuclear matrix [GO:0016363] structural molecule activity [GO:0005198] AQYEDITNCSRL;FINKVRHLEQQNKMLETNNIDNM;VDEAYMNKIELESRL 3 11.4 0.99213 -0.542 0 0 9.75609 0 7.74739 0 0 0 0 0 0 0 0 0 0 A0A8I3ML77 A0A8I3ML77_CANLF Syntaxin-18 STX18 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789] SNAP receptor activity [GO:0005484] DGSRDELFRRSPR 1 3.9 0.94033 0.059821 0 0 8.92416 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3ML84 A0A8I3ML84_CANLF Cadherin 12 CDH12 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] GVIKLKKPLDFETK;QFSFRLSP;VILLAIVVLYVALRRQ;VNEFPPEISVPYE 4 6.9 0.99891 -0.60989 0 0 0 0 0 0 5.53409 8.40369 0 0 9.74938 0 0 0 0 A0A8I3ML86 A0A8I3ML86_CANLF Uricase (EC 1.7.3.3) (Urate oxidase) UOX Canis lupus familiaris (Dog) (Canis familiaris) purine nucleobase catabolic process [GO:0006145]; urate catabolic process [GO:0019628] peroxisome [GO:0005777] urate oxidase activity [GO:0004846] CEHFLSSFNHV;EVEQMRSGPPV;TVKRKLASKL;TWDTVRDIVLEKFAGPYD;VYGDNSDIIPTDTIKN 5 21.9 0.98556 -0.44293 9.03612 0 0 0 8.97582 0 7.64537 0 8.41515 0 8.47934 0 0 0 0 A0A8I3MLA4 A0A8I3MLA4_CANLF "Abhydrolase domain containing 2, acylglycerol lipase" ABHD2 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; negative regulation of smooth muscle cell migration [GO:0014912]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; smooth muscle cell migration [GO:0014909]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; sperm flagellum [GO:0036126]; sperm plasma membrane [GO:0097524] acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; hormone binding [GO:0042562]; hormone-sensitive lipase activity [GO:0033878]; nuclear steroid receptor activity [GO:0003707] HLGFFEGSVLFPEP;VEYANAICQWERNKSQ 2 7.1 0.91252 0.11035 0 0 0 0 0 0 0 9.58126 0 0 0 0 0 0 10.1436 A0A8I3MLB2 A0A8I3MLB2_CANLF Coiled-coil domain containing 68 CCDC68 Canis lupus familiaris (Dog) (Canis familiaris) microtubule anchoring at centrosome [GO:0034454]; protein localization [GO:0008104] centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814] TELENLVQ 1 2.4 0.98285 -0.25034 11.1338 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLB5 A0A8I3MLB5_CANLF Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8) SLC7A8 Canis lupus familiaris (Dog) (Canis familiaris) L-alanine import across plasma membrane [GO:1904273]; L-leucine import across plasma membrane [GO:1903801]; proline transmembrane transport [GO:0035524]; tryptophan transport [GO:0015827]; valine transport [GO:0015829] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; microvillus membrane [GO:0031528] antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-leucine transmembrane transporter activity [GO:0015190]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534] GGGVALKK;GSELEASQETGSTGGGV;KPDIPRPIKINLLFPIIYLLFWAFL;LVTSDMYTLI;MIHVKRCTPIP;SLWSEPVVCGTGLAI;TEELVDPYKNLP;VLRWKKPDIPRPIKINLLFPIIYLL 8 18.6 1.0016 -1.3148 6.4998 7.2737 0 10.5301 0 0 7.54982 0 7.56018 0 0 5.10119 0 4.86111 10.043 A0A8I3MLB8 A0A8I3MLB8_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] PRKLRRLNDYNPQYLPP 1 23.6 0.97983 0.046227 0 3.02899 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLB9 A0A8I3MLB9_CANLF ER membrane protein complex subunit 9 EMC9 Canis lupus familiaris (Dog) (Canis familiaris) EMC complex [GO:0072546] DDIRQDWTNQQ;MRTFEPTKEHHVGGAPEA 2 9.8 0.98486 -0.23701 0 0 0 0 0 0 0 0 0 0 9.41684 0 0 0 0 A0A8I3MLC1 A0A8I3MLC1_CANLF 3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) PDPK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AMSEDDED;ATSREYATRA;EDDEDCYGNYDNLL;EEMGGYSP;MQVSSSSSSHSL;PAMSEDDEDCYGN;PEAKNFKTFFVHTPNRTYYL;SEDDEDCY 8 15.8 1.0004 -2.8126 0 0 6.5413 0 2.54117 7.7985 0 0 0 3.38709 0 8.83996 0 10.1584 0 A0A8I3MLD4 A0A8I3MLD4_CANLF Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) XPR1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to phosphate starvation [GO:0016036]; phosphate ion transport [GO:0006817] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] inositol hexakisphosphate binding [GO:0000822] GLFDKNAG;PLEVFRRFVWNFFRLENEH;PQKAYYYCAIIED;VGFADFWLADQLN 4 8.4 1.002 -1.2296 0 0 0 0 0 0 12.8619 8.78754 0 8.07103 0 0 7.92748 0 0 A0A8I3MLE0 A0A8I3MLE0_CANLF Sarcoglycan delta SGCD Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell development [GO:0055013]; coronary vasculature morphogenesis [GO:0060977]; protein-containing complex localization [GO:0031503] cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] ETEMPQEQYTH;KGLKLEGDSEFLQPLYAKE 2 8.7 0.98299 -0.25186 0 0 4.95559 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLE3 A0A8I3MLE3_CANLF Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) MTR Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; pteridine-containing compound metabolic process [GO:0042558] cytoplasm [GO:0005737] cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270] EAFVISVSHASP;GADIIETNTFSSTN;GVRVSGGLSN;ISVSHASPLCIGLNCAL;PRVPPATVF;SPSVEKPDYRN;TFDELVEAYKEQ;VGEEAKKVYDDAQ;YEDIRQDH 9 8.1 1.0031 -1.9422 9.93025 9.96288 9.75701 8.93543 7.81666 9.49909 0 11.7795 10.1046 0 0 8.92564 10.1436 9.73106 9.89058 A0A8I3MLE6 A0A8I3MLE6_CANLF GSG1 like GSG1L Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AAGNGPPG 1 2.9 0.98999 -0.26575 9.52017 0 0 0 0 0 0 10.7081 0 0 0 0 0 0 0 A0A8I3MLE7 A0A8I3MLE7_CANLF "Golgi associated, gamma adaptin ear containing, ARF binding protein 2" GGA2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] GEAAGGPP;LMPPAVISQML;PSLLHQDLAALGLG;VLSPKYLGSWTT 4 7.3 1.001 -0.64482 12.9321 0 0 0 0 0 0 0 0 0 0 4.16503 0 0 10.9651 A0A8I3MLE8 A0A8I3MLE8_CANLF Uncharacterized protein DYNAP Canis lupus familiaris (Dog) (Canis familiaris) GTHCGCRLPGATLHPQWV 1 11.7 0.97228 0.048313 9.87778 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLF2 A0A8I3MLF2_CANLF "RAB15, member RAS oncogene family" RAB15 Canis lupus familiaris (Dog) (Canis familiaris) Rab protein signal transduction [GO:0032482] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GERRGAPKAESGGGG;GGGGGGGG;PRGPAMAKQ 3 6.2 0.98525 -0.25334 0 0 0 0 0 0 7.61139 0 0 0 0 0 0 0 0 A0A8I3MLG3 A0A8I3MLG3_CANLF "Ribonucleoprotein, PTB binding 2" RAVER2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EVTGHSKGYGFVEYMKKDFAAKA;FVEYMKKDFAA;FVTLLNGEQAQNAIQM;NEKRGSSYLISAPEGGSVEFAD;QPASVGKAEGNFSGSQAY;TAGMGILPFFPNQHIAGQAGHGNT;VGSLLTGHHKQQQSQP 7 19.3 0.98462 -0.24157 9.22694 9.34319 0 0 0 0 0 0 9.45601 8.02126 0 0 10.2252 0 8.30044 A0A8I3MLG7 A0A8I3MLG7_CANLF MAP3K12 binding inhibitory protein 1 MBIP Canis lupus familiaris (Dog) (Canis familiaris) KKKKSSTT 1 2.8 1.0033 -1.1044 0 0 8.61802 0 0 0 0 0 0 0 0 8.86121 8.18908 0 0 A0A8I3MLH3 A0A8I3MLH3_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EELDKGSFV;LSTYVSINSNTGVLYALCSFDYEQV;VIVLLALRLRRWHASRLL;VSGGAKYPE 4 7.3 1.004 -1.0829 0 8.49745 0 8.16355 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLH9 A0A8I3MLH9_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ASLSSYVSINSDTGI;EVSLTAGSQGSHVI;LEGLDYEVSNYYEMEV;NSDTGILYALHSF;TVTLTVAVA;VIVLLALRLRRWHASRLL;YPIEVEIIDINDNA 7 10 1.0029 -0.8505 0 0 0 7.89221 0 0 0 11.4171 10.4936 0 0 9.34937 12.0871 7.33298 0 A0A8I3MLI1 A0A8I3MLI1_CANLF Cadherin domain-containing protein LOC119863934 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;LEVNLQNGILFV;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK;TYTLSPSDYFSL 9 11.8 0.98499 -0.23701 0 0 0 0 0 0 0 7.7707 0 0 0 0 0 0 0 A0A8I3MLI2 A0A8I3MLI2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AVDMLPSGQAV;EVVDVLPSGQAIDVV;IVLMTGEAVDVFVTGE;VLATGETVDVVVSGDP;VLMTGEAVDVVVTGEA;VLMTGEAVGVLMTGDVVDVVPSG;VTGEAVDMLPSGQA 7 7.5 0.98975 0.016403 0 10.5664 0 0 11.4141 0 0 0 9.02769 0 0 0 0 9.09141 7.77591 A0A8I3MLJ1 A0A8I3MLJ1_CANLF BRICHOS domain containing 5 BRICD5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GWWCEAWAPAE 1 4.3 0.98199 0.035491 0 0 9.38739 8.38185 0 0 0 0 0 9.37521 9.61034 0 0 0 0 A0A8I3MLJ2 A0A8I3MLJ2_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] HVFSLDSATGSIITH 1 1.6 0.7493 0.23903 0 13.6932 0 0 0 0 0 0 0 13.8534 0 0 0 0 0 A0A8I3MLJ5 A0A8I3MLJ5_CANLF N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2) AMDHD2 Canis lupus familiaris (Dog) (Canis familiaris) N-acetylglucosamine metabolic process [GO:0006044]; N-acetylneuraminate catabolic process [GO:0019262] N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448] AEEAVQSGATFITHL;AGTKTLSGSIAPMDVCVRHF;AVPALGLGNGRHTLGQQ;GVGGRGGH 4 11.4 1.0027 -0.79935 10.1478 0 0 10.9354 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLJ9 A0A8I3MLJ9_CANLF "Alpha-1,4 glucan phosphorylase (EC 2.4.1.1)" PYGL Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] cytosol [GO:0005829] glycogen phosphorylase activity [GO:0008184]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170] EHTNTGTK;MRVDDVAALDKKGYDAKEYYEALPE;NWPGRSSLQTGPLRKTVR;RFKVFADYEAYVKCQEKVSQLYM 4 9 1.0032 -1.625 11.092 0 8.03634 0 0 7.92778 0 0 0 0 0 0 11.5058 0 8.34461 A0A8I3MLK7 A0A8I3MLK7_CANLF Transmembrane protein 171 TMEM171 Canis lupus familiaris (Dog) (Canis familiaris) DWAQEALNETDSADTE;LGIWVPGCG;VGVLLSIFGFQ 3 11.2 1.0027 -0.71949 0 0 0 0 0 7.0814 0 10.9438 0 6.40015 0 0 0 0 0 A0A8I3MLL2 A0A8I3MLL2_CANLF protein-histidine N-methyltransferase (EC 2.1.1.85) SETD3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; protein-lysine N-methyltransferase activity [GO:0016279] HLRAFARA 1 2.7 1.0037 -1.1044 0 0 0 0 0 0 0 0 9.42545 0 0 0 0 0 0 A0A8I3MLL3 A0A8I3MLL3_CANLF C-C motif chemokine CCL17 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] GRECCLEYFKGA;VTGGGAKS 2 13.4 0.98972 -0.26592 0 0 11.2479 0 0 8.87326 9.65467 0 7.99915 0 0 0 0 11.3839 0 A0A8I3MLM2 A0A8I3MLM2_CANLF Replication factor C subunit 1 RFC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261] DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; DNA clamp unloader activity [GO:0061860] AASKSKEN;EDDSQSDEKDQDSMETDGMI;ETDEEDDFMCK;GVGKTTTASLVCQEL;HYCFDLRFQRPRVEQIK;PCCGGCACCYHHL;PPAMNEIILGANQDIRQV;QDLALHMSLRTYSS;YISETDEEDDFMCK 9 9.9 1.0028 -1.1951 0 6.34609 0 8.3253 0 8.30058 0 8.52258 0 0 6.33117 0 0 9.03604 6.33215 A0A8I3MLM3 A0A8I3MLM3_CANLF Linker for activation of T cells family member 2 LAT2 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; immune response-regulating signaling pathway [GO:0002764] AAGAGGCGCGCGCGCGCG;AAGAGGCGCGCGCGCGCGCG;AAGAGGCGCGCGCGCGCGCGCG;AAGAGGCGCGCGCGCGCGCGCGC;AAGAGGCGCGCGCGCGCGCGCGCEC;AGAGGCGCGCGCGCGCGCGC;AGAGGCGCGCGCGCGCGCGCGCE;AGAGGCGCGCGCGCGCGCGCGCECG;AGGCGCGC;AGGCGCGCGC;AGGCGCGCGCGCGCGCG;AGGCGCGCGCGCGCGCGCGCEC;AGGCGCGCGCGCGCGCGCGCECGC;AGSPDEDNE;AYIDPITTDYYNWGQFQKP;CECECGCEC;CECECGCECGC;CECECGCECGCGC;CECECGCECGCGCGCEC;CECGCGCGCGCECG;CECGCGCGCGCECGCGCECGPL;CECGCGCGCGCECGCGCECGPLS;CGCECGCGCE;CGCECGCGCEC;CGCECGCGCGC;CGCECGCGCGCGCECGCECGC;CGCECGCGCGCGCECGCECGCG;CGCECGCGCGCGCECGCGC;CGCGCECGCGCECGP;CGCGCECGCGCECGPL;CGCGCECGCGCGCG;CGCGCGCECEC;CGCGCGCECGCGCECG;CGCGCGCECGCGCECGP;CGCGCGCECGCGCECGPL;CGCGCGCECGCGCECGPLSP;CGCGCGCGCEC;CGCGCGCGCECECGCECGCG;CGCGCGCGCECGCEC;CGCGCGCGCECGCECGC;CGCGCGCGCECGCECGCGCGCG;CGCGCGCGCECGCGCECGPL;CGCGCGCGCECGCGCECGPLS;CGCGCGCGCGC;CGCGCGCGCGCECGCEC;CGCGCGCGCGCECGCECGC;CGCGCGCGCGCECGCECGCGC;CGCGCGCGCGCGC;CGCGCGCGCGCGCE;CGCGCGCGCGCGCEC;CGCGCGCGCGCGCGC;CGCGCGCGCGCGCGCE;CGCGCGCGCGCGCGCEC;CGCGCGCGCGCGCGCECGC;CGCGCGCGCGCGCGCECGCEC;CGCGCGCGCGCGCGCGC;CGCGCGCGCGCGCGCGCEC;CGCGCGCGCGCGCGCGCECGC;CGCGCGCGCGCGCGCGCECGCE;ECGCECGCGCGCGCECECGCE;ECGCGCGCGCECGCGCECGP;ECGCGCGCGCECGCGCECGPLSP;GAGGCGCG;GAGGCGCGCGCGCG;GAGGCGCGCGCGCGC;GAGGCGCGCGCGCGCGC;GAGGCGCGCGCGCGCGCG;GAGGCGCGCGCGCGCGCGCGCEC;GAGGCGCGCGCGCGCGCGCGCECG;GAGGCGCGCGCGCGCGCGCGCECGC;GCECGCGCGCECG;GCECGCGCGCGCECE;GCECGCGCGCGCECGCECGC;GCECGCGCGCGCECGCGC;GCECGCGCGCGCECGCGCECGPLS;GCGCECECGCECGCGCG;GCGCECECGCECGCGCGCECG;GCGCECGCECGCGCGCGCECG;GCGCECGCGCEC;GCGCECGCGCECGPLSPAPPPPSC;GCGCECGCGCGCG;GCGCECGCGCGCGCECGCECG;GCGCGCEC;GCGCGCECGCGCECGP;GCGCGCECGCGCECGPLSP;GCGCGCGCECE;GCGCGCGCECECGCE;GCGCGCGCECECGCECGCG;GCGCGCGCECECGCECGCGC;GCGCGCGCECECGCECGCGCG;GCGCGCGCECGCEC;GCGCGCGCECGCECGC;GCGCGCGCECGCECGCGC;GCGCGCGCECGCGCECGP;GCGCGCGCECGCGCECGPL;GCGCGCGCGC;GCGCGCGCGCE;GCGCGCGCGCECGC;GCGCGCGCGCECGCECGC;GCGCGCGCGCGCECGCECGC;GCGCGCGCGCGCECGCECGCG;GCGCGCGCGCGCGCEC;GCGCGCGCGCGCGCECGC;GCGCGCGCGCGCGCECGCECGCGC;GCGCGCGCGCGCGCGC;GCGCGCGCGCGCGCGCEC;GCGCGCGCGCGCGCGCECGCE;GCGCGCGCGCGCGCGCECGCECGC;GCGCGCGCGCGCGCGCGC;GCGCGCGCGCGCGCGCGCEC;GCGCGCGCGCGCGCGCGCECGC;GGCGCGCG;GGCGCGCGCGCG;GGCGCGCGCGCGCGC;GGCGCGCGCGCGCGCGCGC;GGCGCGCGCGCGCGCGCGCE;GGCGCGCGCGCGCGCGCGCEC;PLAAGAGGCGCGCGCGCGCGC 118 24.3 0.99702 -6.1843 8.72366 10.5841 9.38513 7.91624 9.2056 11.5464 9.0864 9.95197 9.15031 10.5785 6.87922 9.73613 10.7352 10.4412 10.9661 A0A8I3MLM7 A0A8I3MLM7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AASADITTSIA;AGTSTASPDMSTSTGS;GTTSAAATD;MTTSTAWPD;PEAITSTASPDV;SSVMSTSI;STSTVSPDRTTSSSAQDET;TASPVMSTSPVSPDTT;TTSPEVTSSTAWPVASTS;TVSPDMSTSTMSPDMST;TVSPDRTTS;VTISPALPEASTSI;YILKRNIEDNTYND;YPDMTTSAAWPDGSM 14 6.3 0.95022 0.053874 0 0 0 0 8.11998 0 0 0 0 0 0 0 0 0 0 A0A8I3MLM8 A0A8I3MLM8_CANLF Guanylate cyclase (EC 4.6.1.2) NPR1 Canis lupus familiaris (Dog) (Canis familiaris) cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556] membrane [GO:0016020] ATP binding [GO:0005524]; phosphorus-oxygen lyase activity [GO:0016849]; protein kinase activity [GO:0004672] LDLFGHSLQ;LKWEHSPA;LLLLLLLP;LVAVKRVNRKRIELTRKV;PPLLLLLL;PPLLLLLLL;RKMQLEKELASEL;VEERTQAYL;VIDNFDVY 9 7.4 1.0034 -2.0532 0 0 0 5.72944 0 0 0 0 12.135 0 9.12944 0 0 0 0 A0A8I3MLN5 A0A8I3MLN5_CANLF Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) HCST Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of immune response [GO:0050776] cell surface [GO:0009986]; membrane [GO:0016020] phosphatidylinositol 3-kinase binding [GO:0043548]; signaling receptor binding [GO:0005102] MAPSGDILLLLPVIAAL 1 18.9 0.97657 0.046227 0 0 0 0 0 0 0 0 3.25452 0 0 0 0 0 0 A0A8I3MLP2 A0A8I3MLP2_CANLF Immediate early response 3-interacting protein 1 IER3IP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789] SLTLHGTSSS 1 5.3 0.9916 -0.13653 0 0 0 0 0 0 12.7988 0 0 0 0 0 0 0 0 A0A8I3MLP4 A0A8I3MLP4_CANLF DDB1 and CUL4 associated factor 5 DCAF5 Canis lupus familiaris (Dog) (Canis familiaris) Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737] DCCGSEMACE;DLDGRIEDDSRCLYTHE;FNSGNTKVFSG;GGGGGGGD;HEEYISLVLNSGSGLSHDYANQ;ILHDVESSETLDVF;SEMACETPNAGTREDPTDTPD;SPSPEDESSSSSSSSSSEDE;SSPGHSDTDHDNLSLTG 9 13.9 0.98929 -0.31867 5.3381 0 4.82904 0 10.6124 0 9.54185 0 9.10536 0 12.7389 0 0 0 0 A0A8I3MLQ5 A0A8I3MLQ5_CANLF Uncharacterized protein LOC106557472 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020]; nucleus [GO:0005634] ATPase activator activity [GO:0001671] DEKTLEASVGPRETEE;VGREDALFWS 2 5.6 1.0012 -0.74586 0 0 10.0231 0 0 0 0 0 10.6843 9.36877 0 0 0 9.62611 0 A0A8I3MLQ6 A0A8I3MLQ6_CANLF Zinc finger protein 174 ZNF174 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ELLVLEQFLNILPPEIQARVRHR;RPHLGFSN 2 12.4 0.98764 -0.46168 0 0 0 0 0 0 0 3.70244 0 0 0 0 0 0 6.03031 A0A8I3MLQ8 A0A8I3MLQ8_CANLF "Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (Myosin heavy chain, cardiac muscle beta isoform)" MYH6 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459]; sarcomere [GO:0030017] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DLELTLAKVEKEKHATEN;ELTAKKRK;FSENLNKLMTNL;KSSLKLLSNLFANYAG;MHFGNMKFKQKQREEQ;SEKERLEAQTRPF;TNLSKFRKVQHEL 7 5 1.0026 -0.75988 0 0 0 0 0 9.74972 0 0 0 0 0 0 0 0 0 A0A8I3MLR1 A0A8I3MLR1_CANLF Haloacid dehalogenase-like hydrolase domain-containing protein 2 HDHD2 Canis lupus familiaris (Dog) (Canis familiaris) enzyme binding [GO:0019899]; phosphatase activity [GO:0016791] IGDDCRDDVGGAQNVG 1 6.1 0.98685 -0.23344 9.9279 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLS7 A0A8I3MLS7_CANLF Zinc finger protein 75A LOC119872207 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] QTKELSIWEEELQRLMDLH;RVKVPPKTTGKENHSDTHRMGK;VLVEHLQRESCQT 3 9.4 0.85039 0.15644 0 9.10137 0 0 4.56468 0 0 0 0 0 0 0 0 0 0 A0A8I3MLU1 A0A8I3MLU1_CANLF Doublesex and mab-3 related transcription factor 3 DMRT3 Canis lupus familiaris (Dog) (Canis familiaris) adult walking behavior [GO:0007628]; male sex differentiation [GO:0046661]; regulation of DNA-templated transcription [GO:0006355]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; transmission of nerve impulse [GO:0019226]; ventral spinal cord interneuron specification [GO:0021521] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] DLAEERLGDGGGS;DTLRFSADSANVVPG;VVPGPLAV 3 6.8 0.98918 -0.21644 0 0 0 0 0 0 0 0 0 0 0 0 0 4.67135 0 A0A8I3MLU3 A0A8I3MLU3_CANLF C-C motif chemokine CCL22 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] LPLRLLKYFYWTSDSC 1 17.2 0.9625 0.049233 0 0 0 0 0 0 0 0 7.13186 0 0 0 0 0 0 A0A8I3MLX1 A0A8I3MLX1_CANLF Protein kinase C (EC 2.7.11.13) PRKCQ Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872] GEAVNPYCAVL;PHRFKVYNYK 2 3.3 0.9874 -0.22896 0 0 0 0 0 0 11.4447 0 0 0 0 0 0 0 7.34385 A0A8I3MLX8 A0A8I3MLX8_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST3B1 Canis lupus familiaris (Dog) (Canis familiaris) branching involved in ureteric bud morphogenesis [GO:0001658]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] plasma membrane [GO:0005886] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] ATPPAAGQ;ESLTFKNRSTGLIDTSWSA;LRHFPLGQMLFVSGERLISDPAGE;YRDLMPRTLDGQITMEK 4 17.4 0.98991 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 10.3009 0 0 A0A8I3MLY0 A0A8I3MLY0_CANLF Inhibitory synaptic factor family member 2B INSYN2B Canis lupus familiaris (Dog) (Canis familiaris) EASPPPKSP;PVEEASPPP 2 2.2 0.98661 -0.35882 0 0 0 0 0 0 0 0 0 0 0 9.0082 0 0 0 A0A8I3MLZ2 A0A8I3MLZ2_CANLF RAB7A interacting MON1-CCZ1 complex subunit 1 RIMOC1 Canis lupus familiaris (Dog) (Canis familiaris) mitophagy [GO:0000423] cytosol [GO:0005829]; nucleoplasm [GO:0005654] EGPLKEQEWNTTNAK 1 5.1 0.94987 0.053889 0 0 0 6.39043 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MLZ3 A0A8I3MLZ3_CANLF Transmembrane protein 130 TMEM130 Canis lupus familiaris (Dog) (Canis familiaris) AEVTITASLVANDN 1 3.3 0.98459 -0.25754 0 0 0 0 0 0 0 0 0 0 0 0 8.98783 0 0 A0A8I3MLZ5 A0A8I3MLZ5_CANLF Ajuba LIM protein AJUBA Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] HAUS complex [GO:0070652] microtubule minus-end binding [GO:0051011] FCLFPALPRP;PNSDSDSET;QVLSTYEVLGEE 3 5.8 1.004 -1.0739 0 8.43079 0 9.90369 0 0 0 0 0 0 0 0 0 9.36087 0 A0A8I3MLZ6 A0A8I3MLZ6_CANLF Epithelial membrane protein 3 EMP3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] SKGRDSNSDFL 1 4.6 0.98406 -0.24209 0 0 0 0 0 0 0 0 0 0 0 9.46483 0 0 0 A0A8I3MM09 A0A8I3MM09_CANLF Serine-protein kinase ATM (EC 2.7.11.1) ATM Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; regulation of primary metabolic process [GO:0080090] cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AADIRRKLLML;AELVHIDLGV;AVILCCSPVCEKQALFA;CHILSIYLKGL;DILTKHLVELSIL;EEPSFSEV;EILSKSPDSYQKI;EWCTGTVPIG;GVPEVNGMMKRDGMKIPS;IADICRSLASFIR;KHRILKIYHL;LCQGNMDAENTRDAQ;SLCCDLLSRVCHTAVTYCKDALEN;VEVLLYDPLF;VGSCLGEVGPVDFSTIAIQ;VGSCLGEVGPVDFSTIAIQHSRDI 16 6.8 0.99686 -4.6502 10.9444 9.85414 8.01581 0 11.8868 5.90711 10.07 0 11.7818 0 12.1168 10.8292 0 6.07393 12.1549 A0A8I3MM18 A0A8I3MM18_CANLF Ajuba LIM protein AJUBA Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] HAUS complex [GO:0070652] microtubule minus-end binding [GO:0051011] KVLLRCLALLQRLLQE;QVLSTYEVLGEE 2 11.8 0.96387 0.049233 0 0 6.65263 0 0 0 0 0 0 0 7.15927 0 0 0 0 A0A8I3MM26 A0A8I3MM26_CANLF FXYD domain-containing ion transport regulator FXYD7 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] ion channel regulator activity [GO:0099106] TILFLLGILIIISKKVK 1 22.1 0.97724 0.046227 4.38915 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MM31 A0A8I3MM31_CANLF NEDD4 binding protein 2 N4BP2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA endonuclease activity [GO:0004520]; ubiquitin binding [GO:0043130] CLELALPPELAFQ;DEAIEHLMTVLQQKT;EEFMNEDEQE;KTASSQEVVSSVASLEEPPTTL;PDAFVPSEEFSFKPHKHT;SLTSTNSGPTFPGVVGPQTSVEFP;SPSTCCGENNQEDYD;TGKKLLKT;VLTGQLDGFKPKAFNIN;VLTPLPLL 10 8.5 0.99884 -2.9744 5.20003 0 5.89225 0 7.22033 0 7.20447 10.0286 0 0 4.98085 0 0 0 0 A0A8I3MM32 A0A8I3MM32_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) DDX24 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] KKKKKKGKKKL;LEGSAPTVPKKKKK;PKKKKKKGKK;QKKKKKKK;VPKKKKKKG;VPKKKKKKGKKK 6 3.4 0.99054 -0.26822 0 0 0 0 0 0 0 0 0 0 7.61442 0 0 0 0 A0A8I3MM40 A0A8I3MM40_CANLF Ubiquinol-cytochrome c reductase core protein 2 UQCRC2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] KQVAEQFLNMRGGLGLPG;PPATVLQQIDSVADADIV;YYVQNHFTSARM 3 10.6 0.98634 -0.42024 10.2769 0 0 0 0 0 0 0 0 0 9.94449 4.839 0 0 0 A0A8I3MM57 A0A8I3MM57_CANLF Chromosome 14 open reading frame 93 C8H14orf93 Canis lupus familiaris (Dog) (Canis familiaris) AHGSPPEEPGPL;ELYNPNFQE;GAEEDCDSVGSGMQVVIEEL;PASTPITVT;QEEVGELKQGKASAPD 5 13.2 1.0017 -1.2077 0 7.97103 9.62247 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MM62 A0A8I3MM62_CANLF Cadherin domain-containing protein LOC119863934 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;LEVNLQNGILFV;PLPGGGGG;PPKADLMAFSPSLPRGLDGEV;QENALVSYSLVERR;SLKLKKYLDREKTPE;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK;TVWIEILDANDNAPEVTITSLSLP 12 14.4 0.737 0.2545 0 0 0 0 0 5.72446 9.43511 0 8.60507 0 0 0 5.12974 6.91169 0 A0A8I3MM71 A0A8I3MM71_CANLF Interferon regulatory factor 6 IRF6 Canis lupus familiaris (Dog) (Canis familiaris) cell development [GO:0048468]; cranial skeletal system development [GO:1904888]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; limb development [GO:0060173]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; roof of mouth development [GO:0060021]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; transcription cis-regulatory region binding [GO:0000976]" DEEDEEDELDQSQH;DNDVDEEDEEDEL;HATRHSPQ;PFYSSPEL 4 7.4 1.0023 -1.2458 0 6.76673 0 0 0 8.41865 0 0 0 0 0 0 0 9.49151 8.24151 A0A8I3MM72 A0A8I3MM72_CANLF Forkhead box C2 LOC119863920 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process involved in outflow tract morphogenesis [GO:0003275]; artery morphogenesis [GO:0048844]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; branching involved in blood vessel morphogenesis [GO:0001569]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; collagen fibril organization [GO:0030199]; embryonic heart tube development [GO:0035050]; embryonic viscerocranium morphogenesis [GO:0048703]; glomerular endothelium development [GO:0072011]; glomerular mesangial cell development [GO:0072144]; insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; metanephros development [GO:0001656]; negative regulation of apoptotic process involved in outflow tract morphogenesis [GO:1902257]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; paraxial mesodermal cell fate commitment [GO:0048343]; podocyte differentiation [GO:0072112]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of vascular wound healing [GO:0035470]; regulation of organ growth [GO:0046620]; somitogenesis [GO:0001756]; ureteric bud development [GO:0001657]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] nuclear body [GO:0016604] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALAAAGHHHQH;DHPSGPASPLSAL;DSYNMFENGSFLRRRRRFKKK;SPRSSASTPAGSPDGSL;SSASTPAGSPDGSL;YQFIMDRFPFYRENKQGW 6 15.8 0.98789 -0.46953 0 10.5375 0 0 0 7.30387 0 0 0 0 0 0 0 10.4189 0 A0A8I3MM76 A0A8I3MM76_CANLF GIY-YIG domain-containing protein SLX1A Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of t-circle formation [GO:1904431]; t-circle formation [GO:0090656] Slx1-Slx4 complex [GO:0033557] 5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; metal ion binding [GO:0046872] EEDLELEEEHW;LIWLCRMGNEE;VGPRLRSE 3 11 1.0035 -1.6387 0 8.96564 0 0 14.054 0 0 0 0 0 0 0 0 0 0 A0A8I3MM82 A0A8I3MM82_CANLF Protein max (Myc-associated factor X) MAX Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] RNA polymerase II transcription regulator complex [GO:0090575] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] NDDIEVESDEEQPR 1 17.9 0.93324 0.060819 0 0 0 0 0 0 0 0 0 0 8.33195 0 0 0 0 A0A8I3MM86 A0A8I3MM86_CANLF DNA damage regulated autophagy modulator 2 DRAM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAVLTFGMGSLYMFVQ 1 6 0.95677 0.049233 0 0 0 0 0 10.3736 0 0 0 0 0 0 0 0 0 A0A8I3MM88 A0A8I3MM88_CANLF Cadherin domain-containing protein LOC111091918 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LDENDNAPALLPEPVSRAVG;LEVNLQNGILFV;QENALVSYSLVERR 3 5.9 0.95423 0.050518 0 0 0 0 0 0 0 0 0 0 0 0 10.5188 0 0 A0A8I3MM91 A0A8I3MM91_CANLF Acyl-CoA-binding domain-containing protein 5 ACBD5 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631]; pexophagy [GO:0000425] peroxisomal membrane [GO:0005778] fatty-acyl-CoA binding [GO:0000062] AKSSTLQTSNQP;GSWCCCCCL;QHLTSDSDSEVYCDSMEQF;VDPRLRSMFQFHAGSWGSWCCCCCL 4 9.7 1.0018 -1.2876 0 9.4146 0 0 6.93887 0 0 0 0 11.825 6.56601 7.13155 5.5849 0 0 A0A8I3MMA0 A0A8I3MMA0_CANLF Copine 2 CPNE2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium-dependent phospholipid binding [GO:0005544] ATQQQTATQYFIL;MCYDYDNDGGHDF;MCYDYDNDGGHDFIGEFQTSVSQM;VPLEFECINPKKQR;YDYDNDGGHDFIGEF 5 9.3 0.99432 -0.55787 9.6435 0 0 0 0 5.10664 0 0 0 0 0 11.0543 0 11.4705 11.2916 A0A8I3MMA8 A0A8I3MMA8_CANLF Ras interacting protein 1 RASIP1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of integrin activation [GO:0033625]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] cell-cell junction [GO:0005911]; protein-containing complex [GO:0032991] GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803] DPQLCNDLELCD;TGPVTDDALHREL 2 2.6 0.98994 -0.20064 0 0 0 0 0 9.9508 0 0 0 0 0 0 0 15.912 15.5913 A0A8I3MMD0 A0A8I3MMD0_CANLF MARVEL domain-containing protein CMTM5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASEDGPLNSRSISPWKY;FAQPPHKP;LVGSVEMLSARDRR;SPWKYEFLQ;THWPNCCPSKRQDPTH;TTSLTHHPESCKAS 6 23.8 1.0033 -1.5574 0 9.47094 0 0 0 0 0 9.4103 0 0 0 0 9.15831 0 0 A0A8I3MMD1 A0A8I3MMD1_CANLF Exosome component 10 EXOSC10 Canis lupus familiaris (Dog) (Canis familiaris) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" nuclear exosome (RNase complex) [GO:0000176] 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166] ASGGLPQFGDEYDFY;ESLTDPTI;FTDESYLELYRKQK;LGLTCLMQISTRTEDFI;RERTTSDPR 5 7.3 1.0025 -0.98114 7.26651 9.10468 0 11.6243 0 0 0 0 0 0 0 0 8.52947 0 0 A0A8I3MMD4 A0A8I3MMD4_CANLF Tetraspanin CD53 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MSFFILLLIIL 1 5.1 0.99005 -0.26643 0 0 7.04701 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MME0 A0A8I3MME0_CANLF G protein-coupled receptor 61 GPR61 Canis lupus familiaris (Dog) (Canis familiaris) ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0038035] endosome [GO:0005768]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] arrestin family protein binding [GO:1990763]; G protein-coupled receptor activity [GO:0004930] SESVALFF;SKQFVCFFKP;SSRSTMVTSSGAPQT 3 7.3 1.003 -1.6592 0 0 0 0 0 0 0 0 0 0 10.7108 0 9.42574 0 0 A0A8I3MMF8 A0A8I3MMF8_CANLF Family with sequence similarity 177 member A1 FAM177A1 Canis lupus familiaris (Dog) (Canis familiaris) DEVDGPEKKDVLPTVD;EVIMESKQ;GESGRQMNSERGFE;GVIGKKKKVPRRV;SGETMEEYSTDEDEVD 5 29.6 1.0021 -0.68061 0 0 0 0 0 0 3.848 5.54176 11.2589 0 0 0 0 8.71012 0 A0A8I3MMG1 A0A8I3MMG1_CANLF SGF29 C-terminal domain-containing protein SGF29 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; SAGA complex [GO:0000124] methylated histone binding [GO:0035064] KYEVDDIDEEGKERHTLS;LLTELHQLIKQTQEERSRSEHN 2 13.7 0.92355 0.095196 0 0 0 5.76789 8.13283 0 0 0 0 0 0 0 0 0 0 A0A8I3MMG6 A0A8I3MMG6_CANLF Apoptosis enhancing nuclease AEN Canis lupus familiaris (Dog) (Canis familiaris) exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] EDLAQGTRGETEAQ;EDREPDSSTDMEQYM;SSTDMEQYMEDQ;YMEDQYWPEDLAQGTRGE 4 10.8 0.98681 -0.40913 0 0 7.47143 0 0 8.02813 0 8.84897 0 0 0 9.02614 0 0 10.3013 A0A8I3MMH2 A0A8I3MMH2_CANLF Serpin family B member 13 SERPINB13 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of keratinocyte apoptotic process [GO:1902173] cytosol [GO:0005829]; extracellular space [GO:0005615]; nuclear speck [GO:0016607] cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] EEREIDKTE;LGAAYTHF;LVLVNIVYFKGQ 3 6.7 1.0022 -1.017 0 0 0 4.43109 0 0 9.01594 0 0 0 0 0 0 11.2399 0 A0A8I3MMI5 A0A8I3MMI5_CANLF Rho GTPase activating protein 20 ARHGAP20 Canis lupus familiaris (Dog) (Canis familiaris) regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096] AADVPKSLRRHRRCSEPSIDYLDS;APEELGTVQTAQWYS;DISCFQLN;EAGLFHGEEDYLKRHKSLQMEGQK;EAQCQFILKPSRLAAA;KIKNKIKLCDMWTAS;LSQKDEDYLKQNQ;PQQETLGGQPGRSSSLTGVSRL;SPIDCTFQAQRKQ;VGKSSGTNQNPEKGL 10 14.5 1.0022 -0.69097 0 7.58052 0 9.75711 6.05004 0 0 0 0 9.10324 0 8.27966 9.46156 0 8.71012 A0A8I3MMJ4 A0A8I3MMJ4_CANLF Interferon stimulated exonuclease gene 20 ISG20 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; DNA catabolic process [GO:0006308]; negative regulation of viral genome replication [GO:0045071]; RNA catabolic process [GO:0006401] Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; PML body [GO:0016605] 3'-5'-RNA exonuclease activity [GO:0000175]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U3 snoRNA binding [GO:0034511] RFGHSSVEDAKAAMEL 1 9.4 0.99472 -0.12677 0 0 0 0 0 0 13.9331 0 0 0 0 0 0 0 0 A0A8I3MMJ8 A0A8I3MMJ8_CANLF Phosphoglucomutase-1 (EC 5.4.2.2) (Glucose phosphomutase 1) PGM1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] cytoplasm [GO:0005737] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614] DFGAAFDGDG;LTASHNPGGPNGDFGIKFNISNGG 2 6.2 0.99585 -0.57015 0 0 0 0 0 0 0 0 0 0 0 9.74093 0 9.14682 0 A0A8I3MMK0 A0A8I3MMK0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] DMDDEEGEEDDDEEE;EDDDEGEEG;EDEDDDEGEEGEENEGEDD;EDEGEEDEDDDEGEEGEENEG;IDEEGDEDEGEEDEDDDEGEEGE;LEDIDEEGDEDE;PDMDDEEGEE;YYLVPDMDDEEGEEDDDEEEGLE 8 21.4 0.98595 -0.41475 0 0 0 0 4.93414 0 0 3.31003 0 0 4.75873 0 8.04111 0 0 A0A8I3MML2 A0A8I3MML2_CANLF Neuromedin B NMB Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576]; neuron projection [GO:0043005] LQLSHDLPRILRLKKVL;LRAGGARL 2 19.8 0.97664 0.046227 0 0 0 0 0 0 0 0 8.48675 0 0 0 0 0 0 A0A8I3MML4 A0A8I3MML4_CANLF Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) IDH2 Canis lupus familiaris (Dog) (Canis familiaris) glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] FQEIFEKHYK;TDFDKNKIWYEH 2 5.3 0.99455 -0.56102 0 0 0 0 0 4.87725 0 8.10491 0 0 0 0 0 0 0 A0A8I3MML7 A0A8I3MML7_CANLF BAR domain-containing protein SH3GL3 Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle uncoating [GO:0016191] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793] DINVKQTFIDPLQLLQ;GVSTTASAKTTGSREIPQ 2 13.2 0.93601 0.097546 0 0 7.48365 0 0 0 0 0 0 0 0 0 6.72792 10.6062 0 A0A8I3MMM0 A0A8I3MMM0_CANLF Integrin beta ITGB1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; muscle organ development [GO:0007517] anchoring junction [GO:0070161]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; ruffle membrane [GO:0032587] CECSTDEVNSEDMDAYCRKENSSEI;CGSLIGWRNVTRLLVF;GVCECGAC;ISIGDEVQF;IVLIGLALLLIWKLLMIIHDRREF;KFEKEKMNAKWDTENQS 6 12.4 0.99584 -0.56529 8.49161 0 8.94205 0 0 0 0 0 9.83947 5.57174 10.5897 0 9.01934 0 0 A0A8I3MMN2 A0A8I3MMN2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GCHMNSVP 1 9.1 1.0041 -1.1044 0 0 0 0 0 0 7.67221 0 0 0 0 0 0 0 0 A0A8I3MMP0 A0A8I3MMP0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FMPTTVAIR 1 12.7 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 6.90905 0 0 0 0 A0A8I3MMP5 A0A8I3MMP5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IESDDQDPTNNRP;LVYLLREDSEFTFFII 2 14.9 0.99022 -0.21981 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.86961 A0A8I3MMQ6 A0A8I3MMQ6_CANLF Sushi domain-containing protein CD55 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of complement activation, classical pathway [GO:0045959]; T cell mediated immunity [GO:0002456]" extracellular space [GO:0005615]; plasma membrane [GO:0005886] GLVAGTVIVILIIIKIFWHYG;IVILIIIK;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LPLLLLLLLLLLRPPAARG;NFKWSKPDEFCK;PLLLLLLLLL;PLLPLLLLLLLLL;PLLPLLLLLLLLLL;PLLPLLLLLLLLLLRP;PLLPLLLLLLLLLLRPPA;PPLLPLLLLLLLLLL;PPLLPLLLLLLLLLLR;PPLLPLLLLLLLLLLRPPAAR;PPPPLLPLLLLLLLLLLRPP;STTANVPGTKAT;VPNAQPIL 18 20.8 1.0037 -2.0424 0 0 7.09656 9.45726 5.33242 6.92291 7.49474 0 0 0 6.69446 0 10.1334 9.62642 0 A0A8I3MMQ8 A0A8I3MMQ8_CANLF sphinganine-1-phosphate aldolase (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) SGPL1 Canis lupus familiaris (Dog) (Canis familiaris) androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570] endoplasmic reticulum [GO:0005783] pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117] LLYSDKKYRSHQFFVATD;YDFVFQPESLWSRFKKRCFKLIRK 2 7.4 0.93779 0.089615 0 0 0 0 0 0 8.25583 0 0 0 0 0 0 0 8.91304 A0A8I3MMR0 A0A8I3MMR0_CANLF Mitochondrial E3 ubiquitin protein ligase 1 MUL1 Canis lupus familiaris (Dog) (Canis familiaris) AWPPRARPCPPVTVGPP;GVEQPAQRGAGH;LEVAEGRQ;LRARVRVLLLVLLLDAA 4 11.4 0.98541 -0.23568 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.57054 A0A8I3MMR9 A0A8I3MMR9_CANLF Voltage-dependent R-type calcium channel subunit alpha CACNA1E Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] ADASDEVGMLPASPRAAAS;DEGVLTDGEKEREP;DEQEEEEAFNQKH;DFAISAKPLTRYMPQ;DHEKNKMEVKGREWKRHEFH;DPADDGQF;GGHAGKEPTIQEED;GVDNFFPVQEGEGA;HYRRRRRGGPGP;IERDRRRRHHMSMWEPRSSHLR;IKSLRVLRVLRPLKTIKRLPKL;ISVLRALRLLRI;ISVLRALRLLRIF;IVHHNQPQWLTHLLYY;LRVLRVLRPLKTIKRLP;PQQCSLLE;RPLKTIKRLPKLKA;RVLRVLRPLKTIKRLPKL;SRRRSYHSSL;TIKSLRVLRVLRPLKTIK;VENRRAFMKLRRQQQI;VISQSEPDLSCVT;VLRALRLLRIFKI;VLRPLKTIKRLPKLK;VLRVLRPLKTIKRLP;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKA;VLRVLRPLKTIKRLPKLKAVF 28 10.5 0.9737 0.046699 10.4096 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MMS0 A0A8I3MMS0_CANLF Cytochrome P450 (EC 1.14.14.1) CYP2A13 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" AAKPLLPPTGPPSSQLPL 1 3.7 0.98001 0.048313 0 0 0 0 0 0 0 0 9.09961 0 0 0 0 0 0 A0A8I3MMS1 A0A8I3MMS1_CANLF Alpha/beta hydrolase domain-containing protein 17C (EC 3.1.2.22) ABHD17C Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; regulation of postsynapse organization [GO:0099175] dendritic spine [GO:0043197]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038] palmitoyl-(protein) hydrolase activity [GO:0008474] AGPGACSL;DIELYAQYLE;YSQRELDAVEVFF 3 9.4 1.003 -1.6562 9.44328 0 0 0 0 0 8.76252 0 0 0 0 9.86126 0 0 0 A0A8I3MMS8 A0A8I3MMS8_CANLF DCC netrin 1 receptor DCC Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior axon guidance [GO:0033564]; dorsal/ventral axon guidance [GO:0033563]; neuron migration [GO:0001764]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965] axon [GO:0030424]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] LLVIIVITVGVITVLVVVIV;LVIIVITVGVITVLVVVIVAV;SNLLVIIVITVGVITVLVVVIV;TASLGLAGKARSPL;TLEPNNLWYLFT 5 3.5 0.99357 -0.062982 0 0 8.4824 0 6.26718 0 0 5.81747 9.31628 0 4.16993 0 0 0 0 A0A8I3MMT3 A0A8I3MMT3_CANLF Uncharacterized protein CDR2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] NEQHAKVYEQLDVT;QPELDTSSWEPA;VEEFEMKEDEPWYD 3 8.9 0.99208 -0.1933 0 0 0 0 0 0 0 8.62015 0 0 0 0 0 11.4184 0 A0A8I3MMT9 A0A8I3MMT9_CANLF Protocadherin beta 5 PCDHB5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EVQIPENS;GVWAHNGEVRTARL;LLWEAGSDAIRYSMPE;LLYEKLDREV;MLLKIPEIV;SPETVVAVFSVSDP 6 8.9 1.0008 -2.7503 9.27557 0 0 2.69953 9.20784 0 0 0 0 0 0 0 0 0 0 A0A8I3MMU2 A0A8I3MMU2_CANLF Heat shock protein family B (small) member 1 HSPB1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737]; nucleus [GO:0005634] unfolded protein binding [GO:0051082] APEELTVKTKDGVVEITARREAGA;LFDQAFGLPRLPEEW 2 24.8 0.92292 0.095189 0 0 0 0 0 0 0 8.97965 0 0 0 0 5.45983 0 0 A0A8I3MMU4 A0A8I3MMU4_CANLF Uncharacterized protein LOC488947 Canis lupus familiaris (Dog) (Canis familiaris) response to other organism [GO:0051707] DRENVDKMVR;KDKLDQLRCHFTWELL;KLSRNALDVE;LDEIEFLDTKYK;LDEIEFLDTKYKA;YYHMGRLAEAQAYLDK 6 13.5 1.0034 -1.6172 7.1104 0 0 9.57732 0 0 9.76188 0 13.9195 11.1983 0 0 0 0 0 A0A8I3MMU5 A0A8I3MMU5_CANLF Immunoglobin superfamily member 21 IGSF21 Canis lupus familiaris (Dog) (Canis familiaris) synapse maturation [GO:0060074] external side of plasma membrane [GO:0009897]; inhibitory synapse [GO:0060077]; presynaptic membrane [GO:0042734] GVRLTLVLALTVVLEL;TTENVPETVV 2 5.6 0.98945 -0.21656 0 0 5.04784 0 0 0 0 0 0 9.48716 0 0 0 0 0 A0A8I3MMU6 A0A8I3MMU6_CANLF Vesicle associated membrane protein 4 VAMP4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi ribbon formation [GO:0090161]; SNARE complex assembly [GO:0035493] SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802] EDDSDEEEDFF;ILLLVIIILTVLK;LVAVILLLVIIILTVL;QLRRQMWWRGCKIKAIMALVAVILL;VILLLVIIILTVLKYR 5 36.4 0.85275 0.15803 0 6.12058 0 0 0 0 0 7.08406 0 0 0 0 0 4.99535 0 A0A8I3MMV3 A0A8I3MMV3_CANLF ZFP3 zinc finger protein ZFP3 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MENVESPCTQRAPV 1 2.8 0.98457 -0.25726 0 10.3505 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MMV5 A0A8I3MMV5_CANLF B9 domain-containing protein 2 B9D2 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; MKS complex [GO:0036038] GCGCPSNN;LSPALAPC;RLHTAAGGLVHLELG 3 11.2 1.0017 -1.3119 9.35689 9.15626 0 0 10.2864 0 10.0378 9.41143 7.82744 0 0 0 0 9.66807 9.66821 A0A8I3MMV7 A0A8I3MMV7_CANLF Natural killer cell granule protein 7 NKG7 Canis lupus familiaris (Dog) (Canis familiaris) defense response to protozoan [GO:0042832] cytolytic granule membrane [GO:0101004]; plasma membrane [GO:0005886] CTGDCCSG;SLVGGGGL 2 8.7 1.0036 -2.2088 0 6.50732 0 0 0 0 0 0 0 0 0 0 11.9548 0 0 A0A8I3MMW4 A0A8I3MMW4_CANLF "Transcription factor A, mitochondrial" TFAM Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex assembly [GO:0033108]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation at mitochondrial promoter [GO:0006391] mitochondrial nucleoid [GO:0042645]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; mitochondrial transcription factor activity [GO:0034246] ILQKRLKKKALIKKRELTM;KEILQKRLKKKALIKKRELTMLGKP;KRLKKKALIKK;LEKEILQKRLKKKALIKKRELTM;LQKRLKKKALIKKRE;LQKRLKKKALIKKRELTMLGKPK;QKRLKKKALIK 7 11.4 0.77989 0.23133 0 0 7.20467 0 4.99774 4.1127 4.98089 0 0 0 0 0 0 8.41113 0 A0A8I3MMX5 A0A8I3MMX5_CANLF Calponin-homology (CH) domain-containing protein SMTNL2 Canis lupus familiaris (Dog) (Canis familiaris) GVGDGPAEAAETFPA;STAEHHLLNLASHPD 2 6.5 0.94868 0.055766 0 0 0 0 0 0 6.67186 0 0 0 0 0 0 0 10.5779 A0A8I3MN10 A0A8I3MN10_CANLF Semaphorin 4B SEMA4B Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] semaphorin receptor binding [GO:0030215] ALPPRPPPLLLLLLLVLLLPL;GSRCRHISLYQPETASRPWI;LDTNRGLLYAASYSGVV;LLLLLLLVLLLPLPPPTP;LLLLLLVLL;LLLLLLVLLL;LPPRPPPLLLLLLLVLLLPLP;PDDGFPFNVLQDVFTLSPSPQ;PLLLLLLLVL;PLLLLLLLVLLLP;PPLLLLLL;PPLLLLLLL;PPPLLLLLLLVLL;PPRPPPLLLLLLLVLLLPL;RGALPPRPPPLLLLLLLVLLLP;SPVCPRPRVRL;SSHLFTCGTAAFS 17 13.2 0.98769 -0.33972 11.0466 11.4615 0 4.4034 0 4.82858 0 0 6.67878 0 1.65714 0 8.47375 0 9.75514 A0A8I3MN20 A0A8I3MN20_CANLF Solute carrier family 7 member 5 SLC7A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GVCWALGLAH;LPAFLKLWIELLIIRP 2 5.5 0.99964 -0.61146 9.58273 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MN41 A0A8I3MN41_CANLF Membrane integral NOTCH2 associated receptor 1 MINAR1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of TOR signaling [GO:0032007] plasma membrane [GO:0005886] KSKEMSSPVDLEKHE;KSVSCTSGQL;LDQKMQQPE;NPNNLEYWMEDIYTPGYDSL;TALDLQTQESLNP 5 7.1 1.0033 -0.87319 8.76291 0 0 0 0 8.27342 0 8.58237 11.1406 8.66003 7.02348 0 0 0 10.3269 A0A8I3MN48 A0A8I3MN48_CANLF "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5" ST8SIA5 Canis lupus familiaris (Dog) (Canis familiaris) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" EVHLFGFW;HYYDNVKP;PAFYNTRNTDVSIRVKYVLDDFES 3 11.6 1.0028 -2.1675 0 0 0 4.73568 9.38245 0 0 0 0 5.55683 0 9.74581 0 0 0 A0A8I3MN52 A0A8I3MN52_CANLF A-kinase anchoring protein 5 AKAP5 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcineurin-NFAT signaling cascade [GO:0033173]; positive regulation of endosome to plasma membrane protein transport [GO:1905751]; positive regulation of long-term synaptic potentiation [GO:1900273]; regulation of protein kinase A signaling [GO:0010738] cytoplasmic side of plasma membrane [GO:0009898]; membrane raft [GO:0045121]; postsynaptic recycling endosome [GO:0098837] adenylate cyclase binding [GO:0008179]; calmodulin binding [GO:0005516]; glutamate receptor binding [GO:0035254]; protein kinase A regulatory subunit binding [GO:0034237]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; SH3 domain binding [GO:0017124] IITDTEISEFDV 1 2.8 0.9551 0.05044 0 0 3.76192 0 0 0 9.17093 0 0 0 0 3.35811 0 0 0 A0A8I3MN58 A0A8I3MN58_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD4 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KETPCWIEIH;KRAIESLVKKLKEKK;SNRASTETYSTPA 3 8.3 0.98758 -0.40035 0 0 0 0 0 0 0 0 0 0 0 0 0 6.45411 9.19724 A0A8I3MN71 A0A8I3MN71_CANLF Antizyme inhibitor 2 AZIN2 Canis lupus familiaris (Dog) (Canis familiaris) polyamine biosynthetic process [GO:0006596] catalytic activity [GO:0003824] EQDEDTEGMC;LDQPGREE;LVFENMGAYTVGMGSL 3 7.4 1.0032 -1.6561 0 6.53786 0 0 0 0 10.943 0 0 0 0 0 0 0 8.49665 A0A8I3MN73 A0A8I3MN73_CANLF Matrix metallopeptidase 25 MMP25 Canis lupus familiaris (Dog) (Canis familiaris) hard palate development [GO:0060022]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; plasma membrane [GO:0005886] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ELVSQAPTEPDIL;GRRYWRYDEAAARAD;GVAELVRRRRR;LVRRRRRRR 4 7.3 1.0028 -1.0101 0 0 0 0 0 0 9.70238 0 0 0 0 0 8.04341 0 7.85331 A0A8I3MN77 A0A8I3MN77_CANLF XIAP-associated factor 1 C-terminal domain-containing protein XAF1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] MDKRHLVPELEKCFPVGKP 1 8.2 0.94859 0.04956 0 0 0 0 0 0 8.79312 0 0 0 0 0 0 0 0 A0A8I3MN86 A0A8I3MN86_CANLF RNA-binding protein 42 (RNA-binding motif protein 42) RBM42 Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729] LEVPEPLGEDKK;RRKPRLRARP;VGPVGFGPGDRSH 3 7.4 1.0023 -1.018 9.91498 10.0337 0 0 7.70383 0 0 0 0 0 0 3.3553 0 9.54363 0 A0A8I3MN90 A0A8I3MN90_CANLF Claudin CLDN15 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] TFGFFMAALGLLMLG 1 7.7 0.94579 0.077599 0 0 0 0 0 0 0 0 0 0 0 0 7.19663 0 0 A0A8I3MN92 A0A8I3MN92_CANLF Transmembrane protein 200C TMEM200C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DADGDADGDADAGGEGA;GGGGGGGA;GGGGGGGG;PGGGGGGG;PHGAELDPSPLARAASRS;PPGQVPKRKRKAKRRRK;SAAPAASSPSAGLFFRLFSGY;VGGGGGGG;VGGGGGGGG 9 14.7 0.82093 0.20477 7.68741 4.35064 0 5.01507 0 0 8.95678 0 0 0 0 0 0 0 10.6677 A0A8I3MN96 A0A8I3MN96_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G2D Canis lupus familiaris (Dog) (Canis familiaris) "arachidonic acid secretion [GO:0050482]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; lipid catabolic process [GO:0016042]; negative regulation of T cell proliferation [GO:0042130]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; regulation of acute inflammatory response to antigenic stimulus [GO:0002864]" extracellular region [GO:0005576] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201] DWCCQTHDCCYE;GQPKDATDWCCQTHDCCYEH;KDATDWCCQTHDCCYE 3 13.8 0.99177 -0.54424 0 0 4.75286 0 0 0 0 0 5.96169 0 0 3.98368 0 0 0 A0A8I3MNA3 A0A8I3MNA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GREKVDENCRVC 1 13.8 0.94586 0.05044 0 0 0 0 0 0 0 0 9.67053 0 0 0 0 0 0 A0A8I3MNB8 A0A8I3MNB8_CANLF Transmembrane protein 270 TMEM270 Canis lupus familiaris (Dog) (Canis familiaris) LEILLLVVKLSVLL;NFLLLKILLFNHWL;SPLGRLLRAGLVLMEVP 3 17.2 0.99251 -0.14344 0 0 0 0 0 0 0 3.45589 0 0 0 0 0 0 4.39753 A0A8I3MNE1 A0A8I3MNE1_CANLF GATA binding protein 3 GATA3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]" GAGGGGGG;QGNHVPSYY;SGGGGGGA 3 5.7 0.99196 -0.27195 0 0 0 0 0 0 0 0 0 0 0 0 9.85254 0 0 A0A8I3MNE6 A0A8I3MNE6_CANLF "Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform)" MYH6 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DLELTLAKVEKEKHATEN;DSRKGAEKLLGSLD;ELTAKKRK;FSSYASADVGK;LHEPAVLFN;SEKERLEAQTRPF;TNLSKFRKVQHEL 7 4.5 0.9875 -0.4011 0 0 10.1367 0 0 0 5.16908 0 0 0 0 0 0 0 9.97226 A0A8I3MNF2 A0A8I3MNF2_CANLF BCL9 like BCL9L Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070] nucleus [GO:0005634] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] EVDPPMGPGNLN;GPGQAAQL;GVGGEVYSQPPHMLSP;GVMSPPQGLMTQQNFMLMKQ;LLGRTGVPPQ;PQQQMLMSQK;PSLPFTSSPDPT;PVPSSSQMMPFP;SVSVDSGEQREAGTPSL;TQQNFMLMKQR 10 7.9 1.0025 -1.7683 0 9.69424 0 0 0 0 13.2861 0 12.108 0 0 8.20736 0 5.02032 0 A0A8I3MNG6 A0A8I3MNG6_CANLF Fibrillarin like 1 FBLL1 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835]; methylation [GO:0032259]; rRNA processing [GO:0006364] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] NVAKKRTN;QEYRAWNPFRSKLAAAIL;RGGGGGGF;RKGAASAS 4 14.3 1.0034 -1.5675 7.55098 0 8.24251 0 0 0 0 8.18725 8.17323 0 0 0 0 0 0 A0A8I3MNH8 A0A8I3MNH8_CANLF Uncharacterized protein EDF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DLATKINEKPQVIADYES;GVVHSSLLCPPLLPME;VTVLRKKGPTAAQAKSKQA 3 12.2 0.85714 0.14708 0 0 0 0 0 0 7.22265 0 0 0 0 0 0 0 6.17073 A0A8I3MNI3 A0A8I3MNI3_CANLF Uroplakin 3B UPK3B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FPRLLTDGYYMTLP;LDQLPCEDP 2 8.2 0.98407 -0.24221 0 0 0 0 0 0 0 0 8.78011 0 0 0 0 0 0 A0A8I3MNI4 A0A8I3MNI4_CANLF Yes1 associated transcriptional regulator YAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] QLQMEKERLRLKQQELLRQVRPQ;TVPMRLRKL 2 6.8 1.0027 -0.75796 0 0 0 0 0 0 4.61565 0 0 0 0 0 6.55408 0 0 A0A8I3MNI5 A0A8I3MNI5_CANLF Neuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1) NSG1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin coat assembly [GO:0048268]; endosomal transport [GO:0016197]; G protein-coupled dopamine receptor signaling pathway [GO:0007212] cell projection [GO:0042995]; Golgi cisterna membrane [GO:0032580]; multivesicular body membrane [GO:0032585] clathrin light chain binding [GO:0032051] GWGPPGAL;LSEEKLSEQETEAAEKSAQ 2 5.2 0.9897 -0.21638 0 0 0 0 8.34283 7.46066 0 0 0 0 0 9.21842 0 0 7.80536 A0A8I3MNK1 A0A8I3MNK1_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] MLSLCCWGWVS;PGTLVGNVAQDLG;RDSGRNGEVSL 3 3.7 0.98646 -0.42537 7.55413 0 0 2.00349 0 8.57315 0 0 0 0 9.53912 0 0 0 0 A0A8I3MNK9 A0A8I3MNK9_CANLF BCL2 like 2 PABPN1 Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] mitochondrial outer membrane [GO:0005741] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] APDTRALVADFVGYKL;RVREMEEEAEKLKELQNEV 2 10.6 0.98523 -0.25319 0 0 0 8.40118 8.55394 0 0 0 0 0 0 0 0 0 0 A0A8I3MNL0 A0A8I3MNL0_CANLF Coiled-coil domain containing 7 CCDC7 Canis lupus familiaris (Dog) (Canis familiaris) EERNILESLYQWF;EFIKTHSTEEFID;ESKYSLKAVL;LGSPPTGGSLVRY 4 10.1 1.0025 -1.1764 0 0 0 0 0 6.65549 0 0 11.3227 0 0 0 0 0 0 A0A8I3MNL8 A0A8I3MNL8_CANLF Nuclear receptor corepressor 1 NCOR1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654] DNA binding [GO:0003677]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription corepressor activity [GO:0003714] AENSSDTESAPSPSPV;DIEASNEEENPEDSEGA;DMAAAQPGTEIFNL;EEEMEVAKKGLV;GVPARRMMKNQ;KKLILFFKRRNHARKQR;LEEQRQRQEQIDLE;LPAGGPSISQGLPAS;MMKNQVMRKKLILFFKRRNHARKQR;MRKKLILFFKRRNHA;PPNQGAFSTEQSRYPPHSVQYT;QSTRPIIEGSISQGTPIKFDSNSG;RKKLILFFKRR;SDNDSSATCSADEDVDGEPE;SPMMNRTADV;VCKPKLISKSNSRKSK;VISPASSPVPPPEKLQAYP 17 9.1 0.98223 0.046227 0 0 5.79997 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MNL9 A0A8I3MNL9_CANLF Pleckstrin 2 PLEK2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; intracellular signal transduction [GO:0035556]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034] plasma membrane [GO:0005886] "phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]" AVGQTPLPELS;DKMHDSSSGI 2 5.6 0.98994 -0.22309 0 8.28854 8.34518 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MNN4 A0A8I3MNN4_CANLF Interleukin 10 receptor subunit alpha IL10RA Canis lupus familiaris (Dog) (Canis familiaris) intestinal epithelial structure maintenance [GO:0060729]; negative regulation of autophagy [GO:0010507]; negative regulation of inflammatory response [GO:0050728]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; ubiquitin-dependent endocytosis [GO:0070086] apical plasma membrane [GO:0016324]; cytosol [GO:0005829] interleukin-10 receptor activity [GO:0004920] EAEFFSHILHWTPIP;EGQPGHERSGSALDHIDP;PALAKGYLK;PQFLLPASHPQAEG;VLFCDLTM 5 11.2 1.0019 -1.4329 10.4836 0 8.36571 0 0 0 10.6774 7.3482 0 0 14.6843 0 7.65671 0 0 A0A8I3MNQ2 A0A8I3MNQ2_CANLF Neutrophil cytosolic factor 2 NCF2 Canis lupus familiaris (Dog) (Canis familiaris) phagocytosis [GO:0006909]; respiratory burst [GO:0045730] NADPH oxidase complex [GO:0043020] superoxide-generating NADPH oxidase activator activity [GO:0016176] NKDKHLAVAYFQRGMLYYHMEKYDA 1 5.6 0.97437 0.035538 0 0 7.77735 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MNQ4 A0A8I3MNQ4_CANLF Vasohibin 2 VASH2 Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; syncytium formation by plasma membrane fusion [GO:0000768] cytosol [GO:0005829] actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; microtubule binding [GO:0008017] LEKYARDMR;SHTWERMWMHVAK;WLQAIQNYMKTLQYNHT 3 11 0.98795 -0.22406 0 0 0 0 0 0 0 0 0 0 7.32805 0 10.3393 8.29324 0 A0A8I3MNQ7 A0A8I3MNQ7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK2 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst development [GO:0001824]; centrosome separation [GO:0051299]; mitotic spindle assembly [GO:0090307]; negative regulation of centriole-centriole cohesion [GO:1903126]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of mitotic centrosome separation [GO:0046602] centrosome [GO:0005813]; condensed nuclear chromosome [GO:0000794]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903] REGKFRRI 1 1.8 0.99006 -0.26539 0 0 0 0 0 0 0 0 10.9819 0 0 0 0 0 0 A0A8I3MNQ8 A0A8I3MNQ8_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST2 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] CTYLCYSLLCCCDDL;GVKKGGTRAVLEFIRVH;TLSKKPDIPTFE 3 12.4 0.98674 -0.41036 0 0 0 0 0 0 0 0 0 0 0 0 5.54371 11.4628 0 A0A8I3MNS2 A0A8I3MNS2_CANLF Tetratricopeptide repeat domain 1 TTC1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] SELDEEYLIELE;YQAREACMRLPKQ 2 8.5 0.99555 -0.56779 0 0 0 8.65467 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MNS6 A0A8I3MNS6_CANLF Zinc finger with KRAB and SCAN domains 5 ZKSCAN5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ALPALHVPSL;PYKCQVCGKAFRV;RVHTGEKPYKCQVCGKAFRVS;TAGSTERNVP 4 4.9 0.98643 -0.39497 0 0 0 0 0 0 10.8683 7.71198 0 10.1724 0 0 9.83101 0 0 A0A8I3MNT0 A0A8I3MNT0_CANLF Pecanex-like protein PCNX2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DGSPSPGDCCET;DSVKDILKSDLVICS;ESEGVRDSQAN;GDEEDRGCCCCKPG;GDEEDRGCCCCKPGHL;KENVLAVLLIVL;LSLHTSAASLHS;PMYVSPLTTSYLG;PPFRHRSEGGLV;PSPGDCCETTSPFTP;QRNGSAEQNKDSGLLGDNCSH;SNYRRLGTHW;VKENVLAVLLIVLVSL;WEITRTQYILEG;WFERLYVWLQCFEKY 15 8.5 1.0033 -1.6132 12.7777 0 0 8.21242 4.89608 8.74494 0 0 0 7.69167 10.6483 0 9.65619 9.07735 12.5413 A0A8I3MNU1 A0A8I3MNU1_CANLF Zinc finger and SCAN domain containing 10 ZSCAN10 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PALHTKKQIL;SEPEMKFICTDC;VPEPKPEAREPAIVLC 3 4.9 0.99154 -0.51178 0 0 0 0 0 0 0 0 0 3.78931 2.9318 0 0 0 6.98687 A0A8I3MNU2 A0A8I3MNU2_CANLF ElaC ribonuclease Z 1 ELAC1 Canis lupus familiaris (Dog) (Canis familiaris) rescue of stalled ribosome [GO:0072344]; tRNA 3'-end processing [GO:0042780] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "metal ion binding [GO:0046872]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; tRNA-specific ribonuclease activity [GO:0004549]" AGLRDFIWRTMEL;QEVTLAEDFMVIGIP;VLDLQEVTLAEDFMVIGI 3 8.8 0.9931 -0.17067 0 7.46132 0 0 0 0 11.8476 0 0 0 0 0 8.56419 0 0 A0A8I3MNU6 A0A8I3MNU6_CANLF Rab GTPase-binding effector protein 2 RABEP2 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; endocytosis [GO:0006897]; protein transport [GO:0015031] cell projection [GO:0042995]; centrosome [GO:0005813]; early endosome [GO:0005769] growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096] EQLQTEMQVLLAQV;LVSTGTLVPEGIYLPPPGY;TELLTLSR 3 7.7 1.002 -1.4733 0 0 0 0 0 14.5423 0 0 7.44394 0 8.15502 0 0 0 0 A0A8I3MNV9 A0A8I3MNV9_CANLF Cyclin dependent kinase 9 CDK9 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cytokine stimulus [GO:0071345]; negative regulation of protein localization to chromatin [GO:0120186]; nucleus localization [GO:0051647]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of DNA repair [GO:0006282]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of muscle cell differentiation [GO:0051147]; replication fork processing [GO:0031297]; transcription elongation-coupled chromatin remodeling [GO:0140673] cytoplasmic ribonucleoprotein granule [GO:0036464]; P-TEFb complex [GO:0070691]; PML body [GO:0016605] 7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; transcription coactivator binding [GO:0001223] AAGGGGGG;APAAPGLPGTTSPRG;GAAANSGGG;GGGGGGSG 4 7.8 1.0035 -1.1113 0 0 0 0 0 9.74695 0 0 0 0 0 0 0 0 0 A0A8I3MNW2 A0A8I3MNW2_CANLF Kinesin-like protein KIFC3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ENPGINQRALQLL;VGKSGAEG 2 2.5 1.0041 -1.0446 0 0 0 0 0 0 10.0437 0 9.4632 0 0 0 0 0 0 A0A8I3MNY2 A0A8I3MNY2_CANLF Sialic acid binding Ig like lectin 15 SIGLEC15 Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of osteoclast development [GO:2001204] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] LPLGALGLKALLLLGV;PAEVSAAAGEAAV 2 8.8 0.99456 -0.12622 0 0 0 0 0 0 0 0 0 3.9443 0 0 0 0 0 A0A8I3MNY5 A0A8I3MNY5_CANLF Lemur tyrosine kinase 3 LMTK3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GAFPGGGA;HPALGCPHPPE;LVSETWASPLFP;NPEGEDCSGEYTPPAEE;PPSAVASPGSGLSSPGPK;SAPDASPP;SGVDAKAGWADNTR 7 6.3 0.99012 -0.26592 0 0 0 0 0 10.0077 0 0 0 0 0 0 0 0 0 A0A8I3MP08 A0A8I3MP08_CANLF Uncharacterized protein SERPINA14 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] HTFLFLVDYV;YPVSSWEVSPVHHKIE 2 6.1 0.99258 -0.55288 0 0 0 0 0 12.2248 0 9.47723 0 0 0 0 0 0 2.5567 A0A8I3MP19 A0A8I3MP19_CANLF Tetratricopeptide repeat domain 6 TTC6 Canis lupus familiaris (Dog) (Canis familiaris) AVYFNRAHFYCCLKQ;EPLFLNAYWHRHFIYLFQD;FIYLFQDK;IEEVIASLQSEAQ;IFYDPKRTDAL;KINPCFLDAYVGRGN;KPAVEDAPEG;LSRAIHLQPDGIQLYII;PPGAAAPA;QAQGKFQKAWNHFTIAIEVD;TFINRGLIYVELEQYSFAL;YINKYNKNNAEAYLS 12 9 1.0021 -2.6239 6.36445 10.7752 9.54429 9.49069 8.33047 9.9935 0 10.6929 8.90132 0 4.38667 4.17249 9.53854 6.82757 3.59096 A0A8I3MP41 A0A8I3MP41_CANLF Sulfhydryl oxidase (EC 1.8.3.2) QSOX1 Canis lupus familiaris (Dog) (Canis familiaris) flavin-dependent sulfhydryl oxidase activity [GO:0016971] APRSALYSSSD;APRSALYSSSDPLAL;DMLLGLSVTPAEPD;LFSKEEPT;SVNDWLKR;WDLDNTLRFLKTHFSPSN 6 8.5 1.0026 -1.1802 0 9.8149 9.82413 9.60225 10.4485 9.52675 10.3846 10.602 10.6255 9.83186 8.00904 9.71778 9.99986 10.695 9.84637 A0A8I3MP45 A0A8I3MP45_CANLF Coiled-coil domain containing 9 CCDC9 Canis lupus familiaris (Dog) (Canis familiaris) exon-exon junction complex [GO:0035145] RNA binding [GO:0003723] AAPPPGAA;EDEGEDEEWEDVSEE;EEDEGEEDEGEDEEWEDVSEEEEI;EGEEDEGEDEEWED;EGEEDEGEDEEWEDVS;GTQKAEEEGS;MTLSMTGRERSEYLRWKQEREKIDQ;PDFERVRCGLEQERQGRR 8 14.6 1.0041 -1.0828 0 0 9.07847 8.78388 10.4455 8.5292 0 9.8124 0 9.93081 0 0 0 0 0 A0A8I3MP47 A0A8I3MP47_CANLF Threonine synthase like 1 THNSL1 Canis lupus familiaris (Dog) (Canis familiaris) LAAIHSTYN;SQLEEQHHFQIEKMLV 2 3.4 1.0014 -0.7446 0 0 0 0 0 0 0 11.1268 0 0 0 0 6.61778 0 0 A0A8I3MP62 A0A8I3MP62_CANLF Tubulin tyrosine ligase like 13 TTLL13 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] tubulin-glutamic acid ligase activity [GO:0070740] HPQEIVEEEELE;LSIVAKKIPKK;PVRIQEFIPRI;VGEDEEWTVYWT;VGRRKRRQKRR;VGRRKRRQKRRP;VGRRKRRQKRRPL;VGRRKRRQKRRPLA 8 7.4 0.60096 0.37812 0 0 0 0 0 0 6.02268 0 0 0 8.21228 9.60633 7.66669 0 0 A0A8I3MP73 A0A8I3MP73_CANLF Translationally-controlled tumor protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] calcium ion binding [GO:0005509] NIDDSLICGNAFTYVISSI 1 15.2 0.98431 -0.25293 8.39253 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MP74 A0A8I3MP74_CANLF ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) BST1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cell-matrix adhesion [GO:0001952]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil chemotaxis [GO:0090022]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730] plasma membrane [GO:0005886]; uropod [GO:0001931] "NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; transferase activity [GO:0016740]" QENASELDYQSCPTS;SLITPFLVALASAIQ 2 9.7 0.99427 -0.023922 0 0 0 0 7.81378 7.053 0 0 3.70465 0 0 0 0 0 0 A0A8I3MP79 A0A8I3MP79_CANLF Protein kish-B (Transmembrane protein 167B) TMEM167B Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] GATNRCDWNQAACCCG;VFYKGKILSGQGEEIAI 2 27.5 0.99043 -0.21527 0 0 0 0 0 0 0 11.878 0 0 0 0 0 10.7154 0 A0A8I3MP81 A0A8I3MP81_CANLF Protein spinster homolog 1 (Spns1) SPNS1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] transmembrane transporter activity [GO:0022857] FSQTRPLPSNGPAPSPTVPP;KRLRVPGLPSL;PLTAPHPPAPSSA;VEISRRLRRSNPRAD 4 6.9 0.99746 -0.10782 0 0 0 0 0 0 0 0 10.8569 0 0 0 10.8773 0 0 A0A8I3MP82 A0A8I3MP82_CANLF G protein-coupled receptor 161 GPR161 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EESGEGGA;EVEQIKGWSVGQPG;GTVVIVEEDA;WLHSLIGCLPPL 4 8.8 1.0024 -0.76687 0 0 0 10.7512 0 0 9.75856 0 9.66986 0 0 10.3088 0 0 9.79181 A0A8I3MP84 A0A8I3MP84_CANLF Transcription initiation factor TFIID subunit 7 TAF7 Canis lupus familiaris (Dog) (Canis familiaris) estrogen receptor signaling pathway [GO:0030520]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of MHC class I biosynthetic process [GO:0045344]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; MLL1 complex [GO:0071339]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] H3K27me3 modified histone binding [GO:0061628]; histone acetyltransferase binding [GO:0035035]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription cis-regulatory region binding [GO:0000976] IDTEEDLERQLQEKL 1 4.3 0.98405 -0.24378 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1043 0 A0A8I3MP98 A0A8I3MP98_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP1A3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] IFVYDEIRKLILRRNPGVK;KDFTSEQIDEILQ;YSFLIFVYDEIRK 3 3.5 0.9553 0.04941 0 6.48911 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MPC1 A0A8I3MPC1_CANLF Uncharacterized protein ZKSCAN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] APRGEMTGRFQKDF;DLELDLSG;IVIVKVEEEDEEDHMWG;NPEEKTGREKRDS 4 9.2 0.80846 0.21127 0 0 0 0 10.3254 0 0 0 9.09569 0 0 0 0 0 0 A0A8I3MPC8 A0A8I3MPC8_CANLF Glutamate-rich WD repeat-containing protein 1 GRWD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone binding [GO:0042393] AAPSKACMLTTTS;PSEGSDDDEEEDEEDE;SEGSDDDEEEDEEDEE;SEGSDDDEEEDEEDEED;SEGSDDDEEEDEEDEEDR 5 7.3 0.99141 -0.036966 0 5.15263 8.39129 0 9.55142 0 0 0 1.57584 0 0 0 3.45378 7.58082 16.2773 A0A8I3MPD0 A0A8I3MPD0_CANLF RPGRIP1 like RPGRIP1L Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] EILKTQLRRKENEIE;KENYDKLYNS;KLYNSAFS;QKQQLDDLKHRMKFYNQ;TEITEELEPEEEEDRSASDSDECI 5 5.5 1.0027 -0.73401 7.34038 0 0 0 4.87573 5.70791 0 0 6.75609 0 0 12.4166 0 0 3.85947 A0A8I3MPE3 A0A8I3MPE3_CANLF Myomesin 1 MYOM1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737] M band [GO:0031430] kinase binding [GO:0019900]; protein homodimerization activity [GO:0042803] DPLKKKKDLAAPSP;EIEGAPASPLD;EVSWLKNEKP;INEPTPNDKGKYIM;KRAKKSLLS;MFMEKLQD;VPIFSGRQVHVSGLTDTEEE;YFIDKCEVG;YVPTEDSPRLDIESKGNKTK 9 6.8 0.96579 0.048658 0 0 8.90941 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MPE7 A0A8I3MPE7_CANLF DNA mismatch repair protein MSH6 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] AGFDSDYDQALAD;EEKRRDLHRRRPDHP;ITFLYKFIKGACPKSYGF;PGEKSELALSALGGCV;PSPGGDAA;QSLRLFREVCLASERSTVDAE;SRPTIWYHETLEWLK;STKKGCKRYWTKT 8 9.7 0.98673 -0.40918 8.87952 0 0 0 9.77607 0 6.1358 12.3009 8.38332 8.92615 0 0 8.43675 7.424 0 A0A8I3MPF9 A0A8I3MPF9_CANLF Neuropeptide FF receptor 1 NPFFR1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] LPRPGAEGS;PSQPPNSSWPPSQN 2 4.4 1.0038 -0.80421 0 0 0 0 0 9.07815 0 0 0 0 0 0 0 0 0 A0A8I3MPH1 A0A8I3MPH1_CANLF Zinc finger and BTB domain containing 17 ZBTB17 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] PGSAWPAGQLQ;QHVRIHTAQA;SCRECSKAFSDPAACKAHE 3 5.2 0.99155 -0.18159 0 0 0 8.96316 0 0 0 14.8379 0 0 0 0 0 0 7.78333 A0A8I3MPI1 A0A8I3MPI1_CANLF Uncharacterized protein CLEC18C Canis lupus familiaris (Dog) (Canis familiaris) ATKVHFPFHTCDLR;MQRMDWSESLARW;YKTTKDSFRWT 3 8.6 1.0032 -0.86325 0 0 0 0 11.1289 0 0 10.6671 0 0 0 0 12.241 0 0 A0A8I3MPI2 A0A8I3MPI2_CANLF Cilia- and flagella-associated protein 52 CFAP52 Canis lupus familiaris (Dog) (Canis familiaris) establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317] 9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112] EVFDGSVIRELE;VGSGAGLL 2 3.2 0.9925 -0.55279 4.60845 4.28422 7.30551 0 0 0 0 0 0 17.1293 0 17.1557 17.4127 17.4578 17.5221 A0A8I3MPI3 A0A8I3MPI3_CANLF LIM homeobox 4 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; medial motor column neuron differentiation [GO:0021526]; motor neuron axon guidance [GO:0008045]; negative regulation of apoptotic process [GO:0043066]; placenta development [GO:0001890] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; methyl-CpG binding [GO:0008327]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" CADCQMQLAD;SFREDQILSELG 2 5.6 1.0011 -0.92587 0 0 0 0 0 0 0 0 0 0 8.38849 0 0 0 0 A0A8I3MPI4 A0A8I3MPI4_CANLF Transmembrane protein 198B TMEM198B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLDSDCASTVPL;SVGLFLTGLLLGLTLGAGALLGT 2 10 0.99286 -0.16527 7.5694 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MPI5 A0A8I3MPI5_CANLF Cadherin 24 CDH24 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell-cell junction [GO:0005911]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] RPAPPRQAPYLIPIELWDWGQPALS;SISTDSQGRDGLLAVRKTLDFETR 2 6.3 0.94418 0.07684 0 0 0 0 0 0 0 0 7.31089 8.96454 0 0 0 0 0 A0A8I3MPK7 A0A8I3MPK7_CANLF Solute carrier family 19 member 2 SLC19A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] thiamine transmembrane transporter activity [GO:0015234] ECWFLPTALLC;NLSMERYALVFGV 2 8.1 0.98699 -0.23365 0 0 0 0 0 0 0 0 10.5672 0 0 0 0 0 0 A0A8I3MPK8 A0A8I3MPK8_CANLF Oncostatin M receptor OSMR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESFYEFLVTPY 1 1.2 0.98149 0.035491 0 0 4.49281 0 0 0 0 8.07012 0 0 0 0 0 0 0 A0A8I3MPL0 A0A8I3MPL0_CANLF Castor zinc finger 1 CASZ1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AACQFSLKVTHYHCTRE;DADDDEDDEDDDDEDDDDE;DDEDDDDD;DDEDDDDEDDDDEDDDDD;EDADDDEDDEDDDD;EDDDDEDDDDEDDDDDEDLRTDSEE;EDDEDDDDEDDDD;EDDEDDDDEDDDDEDDD;EEDADDDEDDEDDDDE;EEDADDDEDDEDDDDEDD;HYHCLDPECNYQ;PEEDADDDEDDEDDDDEDDD;SQGPPSLMD;VIEKWVNGEYSEE 14 5.3 0.95121 0.057019 5.2206 0 5.20316 0 8.60674 8.44485 6.78293 0 0 4.41704 6.53574 5.27206 0 8.58195 0 A0A8I3MPL4 A0A8I3MPL4_CANLF Heart- and neural crest derivatives-expressed protein 1 HAND1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cardiac left ventricle formation [GO:0003218]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cartilage morphogenesis [GO:0060536]; embryonic heart tube formation [GO:0003144]; heart looping [GO:0001947]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; odontogenesis of dentin-containing tooth [GO:0042475]; trophectodermal cell differentiation [GO:0001829]; trophoblast giant cell differentiation [GO:0060707]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]" FLFGPASRCHQERPYFQ;PAGGPPPS 2 11.5 0.98256 0.046227 0 0 0 0 0 0 0 0 8.01486 0 0 0 0 0 0 A0A8I3MPP3 A0A8I3MPP3_CANLF Zinc finger protein 174 ZNF174 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] fibrillar center [GO:0001650]; nuclear body [GO:0016604] DNA-binding transcription factor activity [GO:0003700]; protein homodimerization activity [GO:0042803]; transcription cis-regulatory region binding [GO:0000976] ELLVLEQFLNILPPEIQARVRHR;ETRGANMNESRLS 2 8.8 0.9412 0.059725 0 0 0 0 0 0 0 8.9472 0 0 0 0 0 0 0 A0A8I3MPP6 A0A8I3MPP6_CANLF LSM14A mRNA processing body assembly factor LSM14A Canis lupus familiaris (Dog) (Canis familiaris) P-body assembly [GO:0033962]; stress granule assembly [GO:0034063] P-body [GO:0000932] mRNA binding [GO:0003729] ADEEDPLGPNCYYDKTK;RERRPTWAEERRLNAE;VGQQFGAVGVGRS 3 10.9 0.94399 0.059664 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2198 0 A0A8I3MPR4 A0A8I3MPR4_CANLF Gametogenetin GGN Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; gamete generation [GO:0007276] GPGSSSHHSG;PTNGEQESPGP;SLGGGGGL 3 4.8 0.99964 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 10.1869 0 0 A0A8I3MPT7 A0A8I3MPT7_CANLF Spermatogenesis associated 19 SPATA19 Canis lupus familiaris (Dog) (Canis familiaris) sperm mitochondrion organization [GO:0030382] mitochondrial outer membrane [GO:0005741]; sperm midpiece [GO:0097225] HLSKSDLLANQSQDVLE;IESEAVSVVQH 2 18.2 0.98417 -0.24203 0 0 0 0 0 0 0 10.5322 0 0 0 0 0 0 0 A0A8I3MPV5 A0A8I3MPV5_CANLF CD34 molecule CD34 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; endothelial cell proliferation [GO:0001935]; extracellular exosome assembly [GO:0071971]; glomerular endothelium development [GO:0072011]; glomerular filtration [GO:0003094]; hematopoietic stem cell proliferation [GO:0071425]; leukocyte migration [GO:0050900]; metanephric glomerular mesangial cell differentiation [GO:0072254]; negative regulation of interleukin-2 production [GO:0032703]; paracrine signaling [GO:0038001]; positive regulation of angiogenesis [GO:0045766]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of odontogenesis [GO:0042482]; positive regulation of vasculogenesis [GO:2001214]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]; transdifferentiation [GO:0060290]; vascular wound healing [GO:0061042] external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; intercellular bridge [GO:0045171]; perinuclear region of cytoplasm [GO:0048471] carbohydrate binding [GO:0030246]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sulfate binding [GO:0043199] LGMGHTDF;LPGNGSDPPYNST 2 5.4 1.0044 -1.0447 0 0 0 0 0 0 0 0 11.4289 6.79649 0 0 0 0 0 A0A8I3MPW4 A0A8I3MPW4_CANLF Doublecortin domain containing 2B DCDC2B Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] DLADLQNGGQYVA;EEEFKALPYLE;GGGNPAAK;HVFRNGDLLSPP;IHVFRNGDLLSPP 5 13 1.0019 -0.64753 12.0063 0 0 0 9.32865 0 10.547 0 0 0 0 8.47314 0 0 0 A0A8I3MPX5 A0A8I3MPX5_CANLF Cilia- and flagella-associated protein 206 CFAP206 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] AYRYTAIL;TTHLEPFLGSHDL 2 4.8 0.99266 -0.1939 0 0 0 0 0 0 12.2059 0 0 0 0 0 7.80678 0 0 A0A8I3MPZ2 A0A8I3MPZ2_CANLF Uncharacterized protein LOC111098992 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ENLESCLVHAE;VFNHHSSLTQ;VGQKPYTCKECGHT;YKHSALENLHFM 4 7 1.0031 -0.80169 0 0 0 0 6.98425 0 0 0 0 0 0 10.5665 0 0 0 A0A8I3MQ06 A0A8I3MQ06_CANLF Reticulophagy regulator 1 ZNF622 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] membrane [GO:0016020] ADAVDDVEEQDVEEEEAAGGPL;GYTPQTDTSDDWEDIDSDEELEC;HCIAESWMNFSLFLQEMS;TGMKNNATKQMHFRPQ;YLSDLKGLIK 5 19.3 0.99114 -0.22087 0 0 0 0 0 0 0 0 10.1518 0 0 0 0 0 0 A0A8I3MQ11 A0A8I3MQ11_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP14 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136] cysteine-type deubiquitinase activity [GO:0004843]; proteasome binding [GO:0070628] DIGSNNCGYYD;YVSWVKRKQ 2 4.5 1.0027 -0.76872 0 0 0 0 0 0 7.1918 0 0 0 0 0 0 7.66803 0 A0A8I3MQ14 A0A8I3MQ14_CANLF Ring finger and SPRY domain containing 1 RSPRY1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842] ATMGNSCICRDDSGAEDS;GIGDDEYSCAYDGC;IFFLNGNQLPPEKQVFSSTV;IRVIPLEDPLGPAVITLLLDECPL;KIILPRHRRLALLKQ;LNHEGYGIGDDEYSCAYDGC 6 16.8 0.67681 0.30266 0 10.1716 0 6.32742 0 0 0 8.47403 12.7621 0 0 0 0 0 5.44917 A0A8I3MQ18 A0A8I3MQ18_CANLF Chromosome 4 open reading frame 50 C4orf50 Canis lupus familiaris (Dog) (Canis familiaris) KEAHLGEEEKRPRCPTDPGRAPR;LLAELDAPAPGSPCPPGPAGARG;QESPQTASQR;QGLEMCLAREVKPG;RSSPAPRASGQPGRDRYWEK;SRIQDEPL 6 6.5 1.0025 -1.7786 0 0 0 0 0 0 0 10.9954 9.21585 0 0 0 0 9.18356 0 A0A8I3MQ19 A0A8I3MQ19_CANLF "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase (EC 2.4.3.2) (Monosialoganglioside sialyltransferase)" ST3GAL2 Canis lupus familiaris (Dog) (Canis familiaris) ganglioside biosynthetic process via lactosylceramide [GO:0010706]; globoside biosynthetic process via lactosylceramide [GO:0010707]; lipid glycosylation [GO:0030259]; oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486]; sialylation [GO:0097503] Golgi membrane [GO:0000139] "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase [GO:0047288]; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]; protein homodimerization activity [GO:0042803]" EKVQIYNPAFF;MLVLFFALHVCDEDV;VLEKLFQIVPGENPY 3 10.5 0.99235 -0.1328 10.201 0 5.11528 3.33842 0 0 0 0 0 0 0 10.187 4.62141 0 5.98192 A0A8I3MQ61 A0A8I3MQ61_CANLF Tim10-like domain-containing protein TIMM8B Canis lupus familiaris (Dog) (Canis familiaris) VNRKSRAG 1 3.2 1.0039 -1.1044 0 0 0 0 0 8.10203 0 0 0 0 0 0 0 0 0 A0A8I3MQ69 A0A8I3MQ69_CANLF PDGFA associated protein 1 PDAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886] RNA binding [GO:0003723] ESEDEEDDYQ;SLDSDESEDEEDD 2 8.2 0.99264 -0.5519 0 0 3.72857 0 0 0 0 0 5.85225 0 0 0 0 0 0 A0A8I3MQ72 A0A8I3MQ72_CANLF Complement C7 C7 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579] CEEDSADEDKCEDSE;CNGDSDCEEDSADEDKC;EDKCEDSESRPSCDL;LVCNGDSDCEEDSAD;LVGNEAGGVDGGWNCW;PYVRGGSLD;QCQCHCKPYTFGV;SENKCKDLEDVLKSDS;VVFYVDSRKLKQ;YVKHTSAEYTSSSKKSS 10 13.1 0.99345 -0.14253 0 7.18229 0 10.2615 0 0 0 6.44132 13.1515 0 13.5821 0 8.56803 13.7728 10.4627 A0A8I3MQ74 A0A8I3MQ74_CANLF Serine/threonine-protein kinase (EC 2.7.11.13) PRKD2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; regulation of T cell apoptotic process [GO:0070232]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] DHCGEMLFGLVRQGLK;LELQSPPPLLA;LSHPWLQE;PGPGSPPP;SDDSGVIPGSHSENALHASEEEEGE 5 7.7 1.0022 -0.95574 6.62196 0 0 0 0 0 0 12.0971 11.3017 3.24359 0 0 0 0 0 A0A8I3MQ80 A0A8I3MQ80_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VEGPFICTCVSLSLRSHRDTLHT 1 21.5 0.97866 0.046273 0 0 0 0 0 0 0 7.97951 0 0 0 0 0 0 0 A0A8I3MQ90 A0A8I3MQ90_CANLF Valosin containing protein lysine methyltransferase VCPKMT Canis lupus familiaris (Dog) (Canis familiaris) VLEKRDGTV 1 4.6 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 8.01681 0 0 0 A0A8I3MQ92 A0A8I3MQ92_CANLF Hypoxia inducible factor 3 subunit alpha HIF3A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ADLPDEPLMN;EAIPHPGSLEPPLG;ESIVCVHF;GSARTWTRPPS;PSLLSLYPDEDTVEP;QSLSKKKP;SAPQLELIGHSIF;TLTNRGRTLNLKAAT 8 15.7 1.003 -2.4594 0 12.8964 0 6.19663 0 11.5556 0 11.4367 0 6.28427 10.0258 13.0794 7.84053 0 12.5254 A0A8I3MQ98 A0A8I3MQ98_CANLF AP complex subunit sigma AP2S1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] AP-2 adaptor complex [GO:0030122] clathrin adaptor activity [GO:0035615] LKIRFILIQ 1 5.7 1.0045 -0.80421 0 0 0 0 0 0 0 6.93628 0 0 0 0 0 0 0 A0A8I3MQA7 A0A8I3MQA7_CANLF Uncharacterized protein LOC100687713 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] KYKRVKKKKKQQ;YKRVKKKKKQ 2 4.9 0.99455 -0.56102 0 0 0 0 2.94338 0 0 0 0 0 0 0 0 0 5.31969 A0A8I3MQA8 A0A8I3MQA8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LSSQNQMSTRVQLQ 1 19.4 0.94226 0.0611 0 0 0 0 0 0 0 0 7.97051 0 0 0 0 0 0 A0A8I3MQB8 A0A8I3MQB8_CANLF RNA helicase (EC 3.6.4.13) DHX33 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of MAPK cascade [GO:0043410]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of type I interferon production [GO:0032481]; translational initiation [GO:0006413] NLRP3 inflammasome complex [GO:0072559]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; mRNA binding [GO:0003729]; rDNA binding [GO:0000182]; ribosomal large subunit binding [GO:0043023] ETSITITGIK;VLYLECRQ 2 2.6 0.98867 -0.52332 0 0 0 11.2826 0 9.44721 0 0 0 0 0 0 0 0 0 A0A8I3MQC2 A0A8I3MQC2_CANLF Sperm associated antigen 7 SPAG7 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] EQEKQQKVEFRKRMEKEVSDFIQDS;QEKQQKVEFRKRMEKEVSDF 2 13.1 0.94444 0.084196 9.71246 0 0 0 0 0 0 0 10.752 0 0 0 0 4.78916 0 A0A8I3MQC7 A0A8I3MQC7_CANLF TNF receptor-associated factor (EC 2.3.2.27) TRAF2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to nitric oxide [GO:0071732]; innate immune response [GO:0045087]; interleukin-17-mediated signaling pathway [GO:0097400]; mRNA stabilization [GO:0048255]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of immunoglobulin production [GO:0002637]; regulation of JNK cascade [GO:0046328]; regulation of protein-containing complex assembly [GO:0043254]; signal transduction involved in regulation of gene expression [GO:0023019]; tumor necrosis factor-mediated signaling pathway [GO:0033209] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; TRAF2-GSTP1 complex [GO:0097057]; tumor necrosis factor receptor superfamily complex [GO:0002947]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506] CD40 receptor binding [GO:0005174]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; signaling adaptor activity [GO:0035591]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AELQQRCEALERKTATFENIVC;CWADLKAHHEVCPKF;LKDLAMAELEQKVHEME;PERSLSCRHCRA 4 12.6 0.98501 -0.43824 0 7.30122 0 0 0 0 0 9.04666 0 0 0 0 8.66622 0 8.79692 A0A8I3MQD8 A0A8I3MQD8_CANLF "FosB proto-onco, AP-1 transcription factor subunit" FOSB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PEEEEKRRVRR;SVDSFGSPPTAAASQE;TLTPEEEEKR;VLVAHKPG 4 16 1.0021 -1.2779 0 9.57101 0 0 6.37471 0 0 0 0 0 0 0 9.00298 0 0 A0A8I3MQE4 A0A8I3MQE4_CANLF Protein phosphatase 2 regulatory subunit B'alpha PPP2R5A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542] PGPRRCRRRRRRRRRRRRGLPAPP;QAPGPRRCRRRRRRRRRRRRGLP 2 5.2 0.94284 0.087556 0 0 0 0 0 0 0 0 0 0 0 5.92676 0 0 5.78628 A0A8I3MQE6 A0A8I3MQE6_CANLF LIM homeobox 8 LHX8 Canis lupus familiaris (Dog) (Canis familiaris) forebrain neuron development [GO:0021884] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" SFTADQLQVMQAQ 1 3.8 0.98801 -0.26074 0 0 0 0 0 0 0 0 8.28836 0 0 0 0 0 0 A0A8I3MQE8 A0A8I3MQE8_CANLF rRNA adenine N(6)-methyltransferase (EC 2.1.1.-) TFB2M Canis lupus familiaris (Dog) (Canis familiaris) "RNA binding [GO:0003723]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]" KDGDMKITDL;SVPAAGLSP;TSINYDVFFLMLKQCFMKRNFKLM;VIALESNRNFLP 4 14.5 1.0027 -0.73818 0 0 0 7.16521 0 0 0 9.98356 0 0 0 0 0 0 9.56948 A0A8I3MQF1 A0A8I3MQF1_CANLF Chromosome 9 open reading frame 153 C9orf153 Canis lupus familiaris (Dog) (Canis familiaris) SSGTNVREEVFQPIFI 1 16.7 0.99061 -0.19627 0 0 0 0 0 10.1037 0 0 0 0 0 0 0 0 0 A0A8I3MQG4 A0A8I3MQG4_CANLF Thioredoxin related transmembrane protein 1 TMX1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of platelet aggregation [GO:0090331]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of ERAD pathway [GO:1904294]; regulation of calcium ion transport [GO:0051924]; response to endoplasmic reticulum stress [GO:0034976] endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233] enzyme inhibitor activity [GO:0004857]; protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] EEQEADEEDVSEEEAGSKEGTNKDF;SEKEWKSIEPVS 2 13.3 0.98278 -0.24817 0 0 0 0 0 0 0 0 10.618 4.25346 0 0 0 0 0 A0A8I3MQH3 A0A8I3MQH3_CANLF Hyaluronidase (EC 3.2.1.35) SPAM1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] plasma membrane [GO:0005886]; side of membrane [GO:0098552] hyalurononglucosaminidase activity [GO:0004415] DCYNYNYKSPNYN 1 2.4 0.94037 0.059724 0 0 0 0 0 0 0 0 0 7.13165 0 0 0 0 0 A0A8I3MQH4 A0A8I3MQH4_CANLF Claudin CLDN9 Canis lupus familiaris (Dog) (Canis familiaris) tight junction organization [GO:0120193] bicellular tight junction [GO:0005923]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618] GASGLDKRDY;LLLLSGLLVLIPVCWTAHA 2 13.4 0.99419 -0.56205 10.5036 0 0 0 0 0 0 0 0 0 3.7265 0 0 0 0 A0A8I3MQJ4 A0A8I3MQJ4_CANLF T cell receptor delta variable 3 TRDV3 Canis lupus familiaris (Dog) (Canis familiaris) EDSATYYCAIDTHSDTV;IFLVGFSLLLF;LVISQVEPEDS 3 29 0.98716 -0.35146 0 0 0 0 0 0 0 0 10.1411 0 8.66711 0 0 10.4251 9.76951 A0A8I3MQJ9 A0A8I3MQJ9_CANLF Cytochrome P450 2B11 CYP2B6 Canis lupus familiaris (Dog) (Canis familiaris) epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "arachidonic acid epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" LSSRLQLGGRHVD;NFSVASPMAP;VIGPHRLPS 3 6.1 0.99429 -0.02656 0 10.7085 12.6029 0 0 0 0 12.9222 0 0 0 0 0 0 0 A0A8I3MQL7 A0A8I3MQL7_CANLF Adenylate cyclase 10 ADCY10 Canis lupus familiaris (Dog) (Canis familiaris) cyclic nucleotide biosynthetic process [GO:0009190]; intracellular signal transduction [GO:0035556] lyase activity [GO:0016829]; nucleotide binding [GO:0000166] IFIIMSLSPFIDTPC;LEKCWLSMNKDWWY;SGIVFCGI;SRRTPTALYYEGISRYME;VIMPLTHHFL 5 4.1 1.003 -1.5346 0 0 8.33401 4.58039 0 0 0 0 0 0 9.97971 0 7.71644 0 0 A0A8I3MQM2 A0A8I3MQM2_CANLF Hyaluronan binding protein 4 HABP4 Canis lupus familiaris (Dog) (Canis familiaris) PML body organization [GO:0030578]; positive regulation of RNA splicing [GO:0033120]; positive regulation of translational initiation [GO:0045948] Cajal body [GO:0015030]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] RNA binding [GO:0003723]; SUMO binding [GO:0032183] EITAVEESPG;QLEINFGNLPRPG;RGKRDFERYGGNEKIAIRTEDNMGG 3 11.5 0.42384 0.53205 11.4538 11.5556 11.4597 0 0 0 0 0 9.84238 0 0 0 0 11.1482 0 A0A8I3MQM5 A0A8I3MQM5_CANLF Rhotekin 2 RTKN2 Canis lupus familiaris (Dog) (Canis familiaris) hemopoiesis [GO:0030097]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] CRFRARSRLC;IDLEIRMREGIWKLL;KLAKKLKTSISKATGKKINLVLQ;LAKKLKTSISKATGKKINLVLQ;NLSINGNEESSFWLPLYGNM 5 9.6 0.98613 -0.41569 0 0 6.64962 0 0 0 0 10.604 0 8.89545 0 0 0 0 7.97304 A0A8I3MQM7 A0A8I3MQM7_CANLF Prostaglandin D2 receptor PTGDR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] prostaglandin D receptor activity [GO:0004956] FFHKIFIRP 1 2.5 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3656 0 A0A8I3MQN4 A0A8I3MQN4_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DIGTNSLQ 1 0.9 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 9.98342 0 A0A8I3MQP4 A0A8I3MQP4_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) DDX10 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] EEEDGHDADFF;ETICFHATNLQ;EVEEFRAYFN;ICFHATNLQMLVLDEADRIL;IVCELQQKISVL;LLQKKVPVKEIKINPEKL;SSVKKKVTKVAEAKK;YSFLRSHLKKKSIVF 8 12.6 1.0027 -1.5074 9.38918 0 0 0 0 9.90322 0 7.66697 8.79769 0 0 0 0 0 6.08627 A0A8I3MQQ7 A0A8I3MQQ7_CANLF WD repeat domain 73 WDR73 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997] cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922] GVSDSEELSSLQVLD;LVSAPSPDPELLRVTWAPG;SHTGANRCNKTGSP;TEDSDVIQAVSTIAVQEKEDSL;TGSPVCLAPEPGPPPTEPCC;TLLSAASDASLHVWD 6 23.7 0.99053 -0.21055 0 0 0 10.8823 0 0 8.99302 9.37912 9.26983 7.38534 0 0 10.5478 0 0 A0A8I3MQQ8 A0A8I3MQQ8_CANLF Zinc finger protein 792 ZNF792 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KDYSCDMC;PFTVREGGKDFVGGTATSDLP 2 4.9 1.0038 -1.0546 0 0 0 4.63395 0 0 5.87897 0 0 0 0 0 0 0 0 A0A8I3MQT2 A0A8I3MQT2_CANLF Protein Spindly (Coiled-coil domain-containing protein 99) (Spindle apparatus coiled-coil domain-containing protein 1) SPDL1 CCDC99 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cell migration [GO:0016477]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922] enzyme binding [GO:0019899]; kinetochore binding [GO:0043515] AGDVIAFILGMRTQDL;EVNELQYRQEQL;SEDNNLQLEKTVSINT 3 6.3 0.98898 -0.26238 0 11.4622 0 0 0 0 0 0 0 0 0 7.89506 0 0 8.52795 A0A8I3MQV5 A0A8I3MQV5_CANLF Serine/threonine/tyrosine interacting like 2 STYXL2 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine/serine/threonine phosphatase activity [GO:0008138] EANGNSVRS;PEVDISQHFRKAAEFLDEA;RMIREWQSRNERYQAEGHQRWGREE;RQEAPWNEV;RYQAEGHQRWGREEEEQAQEEEEGE;SSTREGREMHKLSRSMFS;TVSHLSGSSWGRASQASK;VGARVHSLTV 8 10.2 1.0029 -1.7204 0 7.33172 9.45422 0 9.58864 0 0 0 0 9.39738 8.88554 6.60171 7.61316 0 0 A0A8I3MQV7 A0A8I3MQV7_CANLF Prolyl 3-hydroxylase OGFOD1 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (uS12 prolyl 3-hydroxylase) OGFOD1 Canis lupus familiaris (Dog) (Canis familiaris) iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline dioxygenase activity [GO:0031543] DLLLYCGCEGWE;DLYDVDEHFQPKQIV;FLEGLQKELLNL;ISGWFHGPSLTRP;LDLYDVDEHFQPKQI;NFIQSQNFLEG;PENNSLALVYRDRETLKF 7 14.3 0.98649 -0.39134 11.5971 0 0 0 7.68243 0 0 0 0 0 9.24308 0 7.97928 0 10.1775 A0A8I3MQW0 A0A8I3MQW0_CANLF TRAF3 interacting protein 3 TRAF3IP3 Canis lupus familiaris (Dog) (Canis familiaris) VALDADDNDCYSTG 1 9 0.93878 0.060958 0 0 0 0 0 0 0 0 0 0 7.79442 0 0 0 0 A0A8I3MQW5 A0A8I3MQW5_CANLF Protein BUD31 homolog BUD31 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] GWELIEPTLDEL;NFGTNCICRVPKS 2 24.3 0.99653 -0.57534 0 0 0 0 0 0 14.5903 0 0 0 0 0 0 0 0 A0A8I3MQX3 A0A8I3MQX3_CANLF Protein YIF1 YIF1B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139] AEGVPVRGARNQ 1 4.8 0.95414 0.05044 0 0 0 0 0 0 0 7.09096 0 0 0 0 0 0 0 A0A8I3MQY3 A0A8I3MQY3_CANLF Coiled-coil domain-containing protein 93 CCDC93 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893] intracellular membrane-bounded organelle [GO:0043231] QLHRRKVISL;SLPEDDDFIKR 2 3.5 0.99082 -0.53785 0 0 0 13.1763 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MQZ0 A0A8I3MQZ0_CANLF "Large ribosomal subunit protein mL46 (39S ribosomal protein L46, mitochondrial)" MRPL46 Canis lupus familiaris (Dog) (Canis familiaris) cell junction [GO:0030054]; mitochondrial large ribosomal subunit [GO:0005762]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] LQEEMAALFQQIE;TAERTLATLSENNLE;TVLGVAKGWRRLEGLR 3 14.7 0.99168 -0.5424 0 0 0 0 0 0 0 9.60557 0 0 0 11.103 0 0 0 A0A8I3MQZ8 A0A8I3MQZ8_CANLF Katanin interacting protein KATNIP Canis lupus familiaris (Dog) (Canis familiaris) DEFLQQQKGSRHGEQ;GWGQVGPAPRQPDA;LELYDERGEKIPLSE;LSVNLQRKQKDGSSDE;NITMEDEHMWL;PASGRRGPRKDTL;PISLHQITA;QLNFTASWGDPHYLGLTGL;QQRNRILKHLKTKDPMQLR;QTLRKGDRSRSCSREKKEAYT;RILKHLKTKDPMQL;WNYNKSPEDTYRGAKIVHISLDGLC 12 10.4 0.94315 0.061061 0 0 0 0 0 0 0 9.47281 0 0 0 0 0 0 0 A0A8I3MR07 A0A8I3MR07_CANLF Zinc finger protein 648 ZNF648 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] RVHNGERPYQ 1 1.8 0.98857 -0.22689 0 0 0 9.37071 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MR08 A0A8I3MR08_CANLF Serine protease 33 PRSS33 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase C signaling [GO:0070528]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] LQALLLLLGAAGGRE 1 5.5 0.95047 0.053897 0 0 0 0 0 0 0 0 0 0 0 0 0 9.41504 0 A0A8I3MR13 A0A8I3MR13_CANLF SH2 domain containing 3C SH2D3C Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] DLHSPMSPISE;DPDSGHYCQ;LHSPMSPISESP;LVAQGLPNPPG;TPKPPGES 5 4.8 1.0035 -1.6218 0 9.33992 10.2996 8.77778 0 4.02334 0 0 0 0 0 9.57777 8.58665 0 8.39111 A0A8I3MR31 A0A8I3MR31_CANLF Trafficking protein particle complex subunit 6B TRAPPC6B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] cis-Golgi network [GO:0005801]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008] SGVYKSAEQGEVE 1 10 0.94394 0.059632 0 0 0 0 0 0 0 0 0 0 0 0 8.22492 0 0 A0A8I3MR37 A0A8I3MR37_CANLF Autophagy related 2B ATG2B Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore assembly site membrane [GO:0034045] lipid transfer activity [GO:0120013] EVELLMAPD;FSDQPVFFREFRFTSEVPIRLDYH;GVLDEKSQIQE;GVSSEQSFYETESARTPSSREE;HEQILYFLNIA;IDQDALFFL;KYEGCDDKHYICLHASSLS;RLSSVPQKAELQIKLNPVFCELD;SPSWNPKIVYEPHPQLTRN 9 7.1 1.0019 -1.4337 7.31388 0 10.7667 0 9.31646 0 0 12.9475 13.0666 0 0 0 0 0 6.003 A0A8I3MR41 A0A8I3MR41_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DAGRRSRRRRRRRRRRWPR;GVHYWELTV;MLGKDDKA;SESPQSRRASGSG 4 6.3 0.95372 0.04941 0 0 0 6.28568 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MR50 A0A8I3MR50_CANLF Calcium/calmodulin dependent protein kinase IV CAMK4 Canis lupus familiaris (Dog) (Canis familiaris) long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of DNA-templated transcription [GO:0045893] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] AKDLVRKLIVLDPKKR;AYLHENGIVHRD;LRLPLPLPPGLRLPPRLRL;RQRRRRRRRWRLPESRRQ;SLRQRRRRRRRWR 5 10.4 0.92851 0.10787 0 4.95313 0 0 0 0 0 0 0 0 0 0 0 0 7.72451 A0A8I3MR65 A0A8I3MR65_CANLF T-complex protein 1 subunit alpha (CCT-alpha) TCP1 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] VPGGGAVEAALSIYLENY 1 4.2 0.99369 -0.17034 0 0 0 0 10.2112 0 0 0 0 0 0 0 0 0 0 A0A8I3MR66 A0A8I3MR66_CANLF RAD51 paralog B RAD51B Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677] DTESAFSAERLVEIA;GVKLVIID 2 8.6 0.98771 -0.36925 0 0 7.96607 12.0699 0 0 0 0 0 7.03848 6.71507 6.67073 0 0 0 A0A8I3MR67 A0A8I3MR67_CANLF KIAA1045 RING finger domain-containing protein PHF24 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] LTETFQQCKVIPDCSLTL 1 4.5 0.97708 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 8.28573 0 A0A8I3MR69 A0A8I3MR69_CANLF Adenosine A2b receptor TTC19 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743] KQPSQAQRMYEKALQ;QEDNAIIEISLKLASIYAAQNRQE;VGEAGAGRPGHAAGGAGRAVRG 3 13.7 0.99288 -0.16673 0 0 0 0 9.24729 9.95776 0 0 0 0 0 0 0 0 9.45343 A0A8I3MR70 A0A8I3MR70_CANLF Kelch repeat and BTB domain containing 3 KBTBD3 Canis lupus familiaris (Dog) (Canis familiaris) ESDELNVPEEETV;LSWTKHNLESRQKHL;VSFLAKACSDFLIK;VVLSWTKHNLESRQK;YDSDCKFPCWACD 5 9.3 0.99301 -0.027481 11.6591 0 0 10.4432 10.1273 0 8.08098 0 7.475 0 0 11.4817 0 5.09419 0 A0A8I3MR78 A0A8I3MR78_CANLF Heat shock protein HSP 90-alpha HSP90AA1 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; cellular response to heat [GO:0034605]; cellular response to virus [GO:0098586]; chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein polymerization [GO:0032273]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of protein localization [GO:0032880]; regulation of protein ubiquitination [GO:0031396]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004] axonal growth cone [GO:0044295]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; disordered domain specific binding [GO:0097718]; DNA polymerase binding [GO:0070182]; GTPase binding [GO:0051020]; histone deacetylase binding [GO:0042826]; nitric-oxide synthase regulator activity [GO:0030235]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase binding [GO:1990782]; scaffold protein binding [GO:0097110]; tau protein binding [GO:0048156]; TPR domain binding [GO:0030911]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] EEEKKKQE;ILKVIRKNLVKKCL;KKKKKKIKEKYIDQ;LFENRKKKNNIKLYVRR;LGIDEDDPTA;NPDHSIIE 6 9.7 1.004 -1.0846 4.23113 0 0 0 0 0 0 0 6.6907 9.71013 0 0 7.43987 7.56879 9.80357 A0A8I3MR87 A0A8I3MR87_CANLF DNA mismatch repair protein MSH6 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] AGFDSDYDQALAD;EEKRRDLHRRRPDHP;FRFLRQSSQVLPLLAHE;PGEKSELALSALGGCV;PSPGGDAA;SRPTIWYHETLEWLK;STKKGCKRYWTKT 7 7.5 0.98074 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 8.94169 0 0 A0A8I3MR88 A0A8I3MR88_CANLF Myocardin MYOCD Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] ADAKASETPLAG;GLKHKVRNRPDRA;GPLAPELD;KKPKDPKPKVKKLK;STSAVPEITQPPSYE;VTPSSSLPGYQSSPTTSA 6 8.6 1.0013 -0.92079 0 9.47377 4.53313 0 0 9.41026 8.57561 0 8.51353 0 0 0 0 0 0 A0A8I3MR94 A0A8I3MR94_CANLF Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) ADGRG1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cerebral cortex regionalization [GO:0021796]; hematopoietic stem cell homeostasis [GO:0061484]; layer formation in cerebral cortex [GO:0021819]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron migration [GO:2001223]; neural precursor cell proliferation [GO:0061351]; positive regulation of cell adhesion [GO:0045785]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Rho protein signal transduction [GO:0035025]; protein kinase C signaling [GO:0070528]; Rho protein signal transduction [GO:0007266]; seminiferous tubule development [GO:0072520]; vascular endothelial growth factor production [GO:0010573] extracellular region [GO:0005576]; glial limiting end-foot [GO:0097451]; membrane raft [GO:0045121]; plasma membrane [GO:0005886] collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; G protein-coupled receptor activity [GO:0004930]; heparin binding [GO:0008201] FIFLWYWSMRLQ;FLWYWSMRLQ;HNPPQKASHNASVDLCELK;SVDLCELK;TSLPSAAGFTFS;VAAVHKHYLTVLS;VLSYVGCVISALAC 7 8.3 1.0011 -0.70598 0 0 6.69864 0 10.6127 8.1419 10.9115 0 0 13.6553 0 0 0 0 10.1404 A0A8I3MR96 A0A8I3MR96_CANLF FERM domain containing kindlin 2 FERMT2 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229] extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925] integrin binding [GO:0005178] DQSEDEALELEG;LSLLKKPRDPTKKKKK;NILSFLKMQHLNPDPQ;QITARILE;QLPNMKYVKVKVNFSDRVFKAVS;QSEDEALELEG 6 12.1 1.0014 -0.64293 0 0 0 0 0 7.48591 0 6.15411 0 0 10.296 0 0 0 6.07112 A0A8I3MRB4 A0A8I3MRB4_CANLF "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3" ST6GALNAC3 Canis lupus familiaris (Dog) (Canis familiaris) ganglioside biosynthetic process [GO:0001574]; glycosylceramide metabolic process [GO:0006677]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity [GO:0001665]" ILKRKSMIAVSFIAAFL;RTHYGYINVRTQE 2 9.8 0.98919 -0.22686 0 0 0 0 3.97453 0 0 0 0 0 0 0 0 8.84731 0 A0A8I3MRB5 A0A8I3MRB5_CANLF TOX high mobility group box family member 3 TOX3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] chromatin DNA binding [GO:0031490] AAAGDPGG;GLHMDQSHTQVPQYRQDHSLIM;LPSQGSEFTPQ;PLTMRLPMNQ;PQPASQQHQSQI;SSMGTTLVGSTSSTQVS;TTINQSQLSAQLGLN 7 16.4 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 13.4488 0 A0A8I3MRC5 A0A8I3MRC5_CANLF VPS9 domain containing 1 VPS9D1 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; endocytic vesicle [GO:0030139] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] CACAEDYYRA;KLLPRDLEATGAGA;QEAANRRF;WPLLLALYRSVHRLREAAL 4 8.3 1.0029 -1.9078 0 0 8.14078 0 0 0 9.74344 0 0 0 0 0 0 0 3.50653 A0A8I3MRC8 A0A8I3MRC8_CANLF ERO1-like protein alpha (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) ERO1A Canis lupus familiaris (Dog) (Canis familiaris) protein folding in endoplasmic reticulum [GO:0034975] endoplasmic reticulum membrane [GO:0005789]; Golgi lumen [GO:0005796] FAD binding [GO:0071949]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] FKASRGAVDAQFVRF;VGLVGAVW 2 3.6 1.0048 -1.0505 0 0 0 0 0 0 0 0 0 8.24641 0 0 0 4.76097 0 A0A8I3MRF6 A0A8I3MRF6_CANLF PARN like ribonuclease domain containing exonuclease 1 PNLDC1 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst formation [GO:0001825]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283] endoplasmic reticulum [GO:0005783] nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] EVQLVLRQA;GVSEQQVYREFQNVCKFDVRR;LHEKFFRPLPESYD;LHEKFFRPLPESYDQFKLNIHNLFP;PESYDQFKLNIH;QQISLFDLPSEWYLKTR;VQLVLRQALPDI 7 14.3 1.002 -1.4635 0 0 0 5.30579 9.77225 0 0 0 0 10.4318 7.11967 0 11.9202 0 0 A0A8I3MRG4 A0A8I3MRG4_CANLF ELMO domain containing 1 ELMOD1 Canis lupus familiaris (Dog) (Canis familiaris) RMLFQVCLYFYC;VCLYFYCKFLWRCL 2 5.7 0.99125 -0.18133 0 7.31306 0 0 8.43567 0 3.82701 0 4.37934 0 0 0 0 0 0 A0A8I3MRG7 A0A8I3MRG7_CANLF Junctophilin JPH3 Canis lupus familiaris (Dog) (Canis familiaris) exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168] endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; plasma membrane [GO:0005886] DGGSYCGGWED;EDHRADDRGFGTQRLRSKSQ;ETYSDGGTYQGQWV;GAKLLELDEEKLS;QSVPYGMAAVI 5 9.2 0.99609 -0.014352 7.60726 5.45375 0 8.50942 8.75932 6.23525 7.8767 0 0 0 0 0 0 0 0 A0A8I3MRH0 A0A8I3MRH0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DVATVTGPMAAYVQEGP;MTVWTGDVVGGGT;NNEITYYFPCQ;TDRFFLETLELAMARLRPAAK;VLPSEDEEGGGGG;VVGGGTDSNIFMTLY 6 7.5 0.95035 0.049792 4.29263 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MRI2 A0A8I3MRI2_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEHHLRDY;GGGCGGSGDG;SGSGNFGG 3 9.1 0.99094 -0.27458 0 0 0 0 0 0 0 0 6.91839 0 0 0 0 0 0 A0A8I3MRJ3 A0A8I3MRJ3_CANLF Actin like 8 ACTL8 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855] GVEHIWSFVLERH;KAGFSGWNEPQMVFP;NFSVWLGASVVAH;WNEPQMVFPSIVNY 4 12.6 0.98262 -0.25027 0 0 0 0 8.44845 0 7.64147 0 0 0 0 0 9.35182 0 8.20545 A0A8I3MRK4 A0A8I3MRK4_CANLF NOP2/Sun RNA methyltransferase family member 7 NSUN7 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] DAWVRPQGP;GSGGDSPT;IESKDHRLQKVKVILLLP;IVMLYDFQDRKF;KKKKKSKTSLPKAP;KVKVILLLPRC 6 6.7 1.0029 -1.4928 8.98672 0 10.1737 11.9672 0 0 0 0 0 4.48646 0 0 0 0 0 A0A8I3MRK7 A0A8I3MRK7_CANLF Retinol dehydrogenase 12 RDH12 Canis lupus familiaris (Dog) (Canis familiaris) cellular detoxification of aldehyde [GO:0110095]; visual perception [GO:0007601] photoreceptor inner segment [GO:0001917] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650] PGVVSSEL 1 2.5 0.99228 -0.16709 0 0 8.30606 0 0 0 0 0 0 0 0 0 0 7.7057 0 A0A8I3MRK9 A0A8I3MRK9_CANLF Alpha kinase 3 ALPK3 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell development [GO:0055013] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAPGAPGPSPTLVP;ATKGQSEKGSMASLSPQSRVPE;DQAQKAPAPGPVPGP;EARRPRRLV;EDSDARFTCIVTGYPEPEVT;ELAADEGK;ELAADEGKQDTP;IPYATLEEDLGK;LLLLLKLSSTETG;NWKPRKEVVGDVDTLRK;QEGSVGGP;SNSRGQGVIEP;VGTMTEYKIHQRWF;VTQAERTQTDERMQED 14 9.6 0.99879 -2.9808 8.68352 16.8703 0 0 11.6622 8.61791 8.2731 0 11.042 0 14.5489 0 9.67772 10.3182 12.9381 A0A8I3MRL3 A0A8I3MRL3_CANLF INSM transcriptional repressor 2 INSM2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] APTLEQAAAARDLS;EVFMCPYCH;RCPECDKVFS;SPDSGAVASFLAEG;SPDSGAVASFLAEGKEDSRAERA 5 10.1 0.98989 -0.51626 0 0 0 0 10.3784 11.1691 13.0377 0 0 0 0 8.71407 12.5374 0 0 A0A8I3MRL4 A0A8I3MRL4_CANLF serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (Seryl-tRNA(Ser/Sec) synthetase) SARS2 Canis lupus familiaris (Dog) (Canis familiaris) seryl-tRNA aminoacylation [GO:0006434] ATP binding [GO:0005524]; serine-tRNA ligase activity [GO:0004828] LHFRVLDMPTQE;VFEGCGMTPNANPSQIYN 2 5.9 0.99056 -0.26868 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.73291 A0A8I3MRL6 A0A8I3MRL6_CANLF Receptor protein-tyrosine kinase (EC 2.7.10.1) ERBB3 Canis lupus familiaris (Dog) (Canis familiaris) cranial nerve development [GO:0021545]; endocardial cushion development [GO:0003197]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; motor neuron apoptotic process [GO:0097049]; myelination [GO:0042552]; negative regulation of cell adhesion [GO:0007162]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of secretion [GO:0051048]; negative regulation of signal transduction [GO:0009968]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle tissue development [GO:0055025]; positive regulation of gene expression [GO:0010628]; regulation of cell population proliferation [GO:0042127]; Schwann cell development [GO:0014044] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; ERBB3:ERBB2 complex [GO:0038143]; extracellular space [GO:0005615]; lateral plasma membrane [GO:0016328] ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; identical protein binding [GO:0042802]; neuregulin binding [GO:0038132]; neuregulin receptor activity [GO:0038131]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625] DNGRSCPPC;EEEEEDEEYEY;ELEPELELDLDLETE;EVELEPELEL;FRDGPHCVSSCPNGV;GACVRQCPQPL;GHCFGPNPNQCCHDECAGGCSGP;GTTPDEDYEYMN;IDVYMVMV;QCCHDECAGGCSGP;SLLTPVTPLSPP;TVVVGLAVIFLILG 12 10.3 1.0023 -1.1745 20.0842 11.4528 10.753 15.7663 18.8377 19.0412 19.9727 14.3588 11.1283 10.8535 10.1616 19.9059 20.1604 11.2602 10.5623 A0A8I3MRL7 A0A8I3MRL7_CANLF Complement component C9 C9 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; killing of cells of another organism [GO:0031640]; protein homooligomerization [GO:0051260]" extracellular space [GO:0005615]; membrane attack complex [GO:0005579]; other organism cell membrane [GO:0044218] CNGDNDCGDFSDE;CNGDNDCGDFSDEDDC;CNGDNDCGDFSDEDDCE;CNGDNDCGDFSDEDDCES;CNGDNDCGDFSDEDDCESD;CNGDNDCGDFSDEDDCESDP;DCGDFSDEDDCE;DNDCGDFSDEDDC;DNDCGDFSDEDDCESDP;EDDCESDP;NGDNDCGDFSDEDDCE;TTTFLDDIKALPSTYEKGEYF;VGDRRQCEPAEP 13 9.3 0.99104 -0.22198 0 0 0 0 0 0 0 0 0 11.2661 0 0 0 0 0 A0A8I3MRM0 A0A8I3MRM0_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP6 Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; siRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141007]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; synaptonemal complex [GO:0000795] Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GEDITLWGMELGLL 1 4.3 0.9852 -0.24511 9.8889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MRN1 A0A8I3MRN1_CANLF DNA helicase (EC 3.6.4.12) CHD9 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] ANLFGETLEGLSDDAFVQP;ASTSQQSLSMQQ;DINVVVYHGSL;GSVKIKKNSA;LVDELNLGAEFEPL;PNHTNQTLSDFTGS;RQQRWTRREEADFYRV;SENGGENS;SPFHQQGH;SSSSEESDSEEEE;TNTSLNSNNFQ 11 4.8 1.003 -2.303 12.4184 0 12.759 6.14757 10.3324 4.65243 13.4433 0 13.6965 0 0 13.0661 6.16076 0 0 A0A8I3MRP0 A0A8I3MRP0_CANLF AKT serine/threonine kinase 3 AKT3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EIMRHSFFSGVNWQDVYDKKFSLFS 1 5.9 0.97952 0.035538 7.56293 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MRQ2 A0A8I3MRQ2_CANLF FH2 domain-containing protein FMN2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DIQHAVVNLDNSVVDLE;GGGGGGGE;GGGGGGGG;PGAGDTDEEGEEDAFE;SPNHSPSQSP;YPALDMEVASGR 6 3.7 0.9958 -0.11408 5.44108 5.68924 0 0 4.63691 10.7505 0 14.4465 0 0 0 0 5.21785 5.71811 5.99166 A0A8I3MRQ6 A0A8I3MRQ6_CANLF Zinc finger and BTB domain containing 18 ZBTB18 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] heterochromatin [GO:0000792]; nuclear speck [GO:0016607] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]" ADSTKKEEDASSCSDKVESLSDG;AGIPPAGGE;ARVQYEPAHLAP;LASCSMYFHLFY 4 10.5 0.98734 -0.46354 5.9503 0 0 9.53432 0 0 0 15.3807 0 0 0 0 0 9.35156 0 A0A8I3MRQ7 A0A8I3MRQ7_CANLF Large ribosomal subunit protein mL46 MRPL46 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LDKGHWLSPCFVF;LQEEMAALFQQIE;TVLGVAKGWRRLEGLR 3 24.7 0.98536 -0.25331 0 0 0 0 0 0 0 0 0 0 0 10.7256 0 0 0 A0A8I3MRQ9 A0A8I3MRQ9_CANLF Solute carrier family 35 member F3 SLC35F3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVRVIAIIIIGLGFLLLLL;GVRVIAIIIIGLGFLLLLLP;HYTSKIVFNGVRVIAIIIIGLGFL 3 7.3 0.8816 0.13892 5.63462 0 4.04588 0 0 0 0 0 0 0 0 0 0 6.09717 0 A0A8I3MRS2 A0A8I3MRS2_CANLF Transmembrane serine protease 4 TMPRSS4 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] AALLSVAIIIIVAVLI;AALLSVAIIIIVAVLIKVIL;CDGQQDCASGEDE;IIAALLSVAIIIIVAVLIKVI;IIAALLSVAIIIIVAVLIKVIL;IPIIAALLSVAIIII;KKVGIPIIAALLSVAIIIIVAVL;LVSLHCLACGESLKAP;PIIAALLSVAIIIIVAVLI;VGIPIIAALLSVAIIIIVAVL;VGIPIIAALLSVAIIIIVAVLIKV;VYTKVTAYLNWIY 12 17.4 0.99373 -0.061052 0 5.68488 6.66448 0 7.09339 7.21587 7.28993 0 7.93044 0 0 0 7.78568 7.40803 0 A0A8I3MRS7 A0A8I3MRS7_CANLF Glutamate receptor GRID1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of postsynapse organization [GO:0099175]; social behavior [GO:0035176] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] MHIPHLFV;SVSSKGYGIAL;VEYAALTDDDCSVTV;VGVLIFVLNRIQAVR 4 4.9 1.0029 -0.86104 10.6088 0 0 0 0 0 0 0 8.82703 0 0 0 0 10.7486 0 A0A8I3MRT7 A0A8I3MRT7_CANLF Uncharacterized protein ADAMTS15 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AAGHGGAP;AGHGGAPL;DRRNRRGAGGAGG;LKGTCVERHNLNKYRVD;NKYRVDGFWAKWEP;PGGWGGGG;RDLVVKGS 7 5.2 0.99672 -4.8301 9.43802 0 8.43229 10.6925 8.35495 0 9.38562 10.2494 0 0 0 9.81949 0 0 0 A0A8I3MRU3 A0A8I3MRU3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) DTSTKAKETKAKMNYWDFMKIRSF;TNHMILSLDAEKAFDKIQHPF;WNRIENPEVDPQLYGQL 3 7.8 0.96542 0.048461 0 10.4485 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MRV1 A0A8I3MRV1_CANLF Neuropilin and tolloid like 2 NETO2 Canis lupus familiaris (Dog) (Canis familiaris) glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839] ionotropic glutamate receptor binding [GO:0035255] FIPDPDFTYLGG;IVLVLLIISILVQVKQPRKKV;LCAVLKVLLITVLV;NECKRNFVAVYDGS;NSLVCNGVQNCAYPWDENHCKE;RSSQVEQEEKTKPG;TSGIVLVLLIISILVQ;VLVLLIISILVQVKQPRK 8 19 0.9334 0.060805 6.61924 7.58519 0 0 0 6.83693 7.54365 0 4.70901 0 0 0 0 0 0 A0A8I3MRV8 A0A8I3MRV8_CANLF Sodium/potassium-transporting ATPase subunit beta-1-interacting protein (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein) NKAIN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] ATPase binding [GO:0051117] FLEEEDSCCALGVCSTR;IFLALFGFVFACY 2 14.3 0.98973 -0.26611 0 0 0 0 6.92386 0 0 0 0 0 0 0 0 0 0 A0A8I3MRV9 A0A8I3MRV9_CANLF E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (Leukocyte-endothelial cell adhesion molecule 2) SELE Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246] IYIKRDKDSGKWNDERCDKKKLALC;MTCTFECEEGFE;SFLLWLLKRLRKRGKG 3 8.7 0.95769 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 5.42942 0 0 A0A8I3MRW2 A0A8I3MRW2_CANLF TAR (HIV-1) RNA binding protein 1 TARBP1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423] AGAGRAEDAAALAAGRLL;AMMVLLAVDVEGM;KYFIEWIIILILHKFP;LDSLDAGPTERF;PEKKPILKQALIIV;SALAERLLPEP;TYVSLLPEEI;VLQWCFNHN;YALVALKK 9 7.1 1.0027 -0.77946 0 0 0 9.18222 0 8.57558 8.36711 0 8.41177 0 0 0 9.64026 8.82544 9.4207 A0A8I3MRW3 A0A8I3MRW3_CANLF Retinaldehyde binding protein 1 RLBP1 Canis lupus familiaris (Dog) (Canis familiaris) FRLQYPELFDS;NWDSEEITFDE 2 6.9 0.98986 -0.21701 0 0 0 0 0 0 11.5361 0 10.5182 0 0 0 0 0 0 A0A8I3MRW6 A0A8I3MRW6_CANLF "RAB12, member RAS onco family" RAB12 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; Golgi vesicle fusion to target membrane [GO:0048210]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904] endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GGGGGGSG;KSTVDFVVTKE;PEPEIPPELP 3 8.1 0.98808 -0.22408 0 0 0 0 0 0 0 0 7.33459 0 0 0 7.62775 0 7.91247 A0A8I3MRY2 A0A8I3MRY2_CANLF Chromosome 14 open reading frame 28 C8H14orf28 Canis lupus familiaris (Dog) (Canis familiaris) FLYLMDTYSFTTVK;FWRPVLPWG;IDGFLMLLYVILNE;NLENLMSTIQESY 4 17.9 1.0039 -0.82211 0 0 0 0 0 5.93711 0 0 0 0 0 0 8.85891 0 0 A0A8I3MRY5 A0A8I3MRY5_CANLF Apolipoprotein A-V (Apolipoprotein A5) APOA5 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol homeostasis [GO:0042632]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of triglyceride catabolic process [GO:0010898]; positive regulation of very-low-density lipoprotein particle remodeling [GO:0010902]; tissue regeneration [GO:0042246]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; triglyceride-rich lipoprotein particle remodeling [GO:0034370] chylomicron [GO:0042627]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; high-density lipoprotein particle [GO:0034364]; late endosome [GO:0005770]; very-low-density lipoprotein particle [GO:0034361] heparin binding [GO:0008201]; lipase binding [GO:0035473]; lipoprotein lipase activator activity [GO:0060230]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine binding [GO:0031210] SLKDSLEQDLSKMDKF;VGMRQQLQ 2 6.5 1.0046 -1.0535 0 0 0 0 0 0 9.3419 0 0 0 0 0 0 0 6.81686 A0A8I3MRZ6 A0A8I3MRZ6_CANLF G protein-coupled receptor 37 GPR37 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to reactive oxygen species [GO:0034614]; dendrite development [GO:0016358]; dopamine biosynthetic process [GO:0042416]; locomotion involved in locomotory behavior [GO:0031987]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of MAPK cascade [GO:0043410] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151] Hsp70 protein binding [GO:0030544]; neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; PDZ domain binding [GO:0030165]; prosaposin receptor activity [GO:0036505]; ubiquitin protein ligase binding [GO:0031625] AFMECCCCCCDE;AFMECCCCCCDEC;AFMECCCCCCDECIQ;APLARTSRLLLLLLLKL;CCCCCCDECI;CKPFSRAFMECCCCC;ECCCCCCDEC;ECCCCCCDECI;FMECCCCC;FMECCCCCCDE;FMECCCCCCDEC;FMECCCCCCDECI;FMECCCCCCDECIQ;GAGISGHSQEP;GAPLARTSRLLLLLLLK;GVTTFTLCALCIDRFRAATNVQMYY;MECCCCCCD;MECCCCCCDE;MECCCCCCDEC;MECCCCCCDECI;MECCCCCCDECIQKSSTVTSDDNDN;NSTHRRLRLKNPFY;PLARTSRLLLLLLLKLSASP;RAFMECCCCCCDECI;RLLLLLLL;RLLLLLLLK;SRAFMECCCCCCD;SRAFMECCCCCCDEC;SRAFMECCCCCCDECIQ 29 17.1 0.99671 -4.2875 5.33478 7.57894 7.91319 8.478 7.56613 5.64267 0 7.90839 0 7.51562 6.71438 0 3.75328 6.93817 12.1004 A0A8I3MS09 A0A8I3MS09_CANLF Dynactin subunit 4 DCTN4 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; dynactin complex [GO:0005869]; sarcomere [GO:0030017]; stress fiber [GO:0001725] DQKEIKIEPAQAVDE 1 3.3 0.99613 -0.11361 9.52532 9.92446 0 0 0 0 10.6646 0 0 0 0 0 0 0 0 A0A8I3MS14 A0A8I3MS14_CANLF Regulator of G protein signaling 7 RGS7 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] GTPase activator activity [GO:0005096] EFLAPGAPSA;TFYRFQTPYFWPSNC 2 6 0.95076 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.24771 A0A8I3MS47 A0A8I3MS47_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) UCHL1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cysteine-type deubiquitinase activity [GO:0004843] KKKKKKKK;KKKKKKKN;NFAKKKKKKKKKNRLHQR;QEVSPKVYFMKQT;RNFAKKKKKKKKKNRLHQ;VSRNFAKKKKKKKKK 6 7.2 0.80098 0.2103 0 0 5.65423 0 0 0 0 0 0 9.69745 0 0 8.05555 9.00065 0 A0A8I3MS65 A0A8I3MS65_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ESQTIFLDYAYS 1 8.8 0.99148 -0.1483 0 0 0 0 0 10.4421 0 0 0 0 0 0 0 0 0 A0A8I3MS66 A0A8I3MS66_CANLF Peptidase S1 domain-containing protein PRSS22 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] HCAVPLAH 1 4 0.99301 -0.1652 0 0 9.25082 9.44058 9.63098 10.1196 0 0 0 0 9.76674 0 0 0 9.80471 A0A8I3MS69 A0A8I3MS69_CANLF Cathepsin L1 CTSL3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] GVLVVGYGFEGAESDNKKYW 1 5.9 0.94966 0.050109 0 0 0 0 0 0 0 8.96038 0 0 0 0 0 0 0 A0A8I3MS70 A0A8I3MS70_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member ANP32B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEEDEDEDEDVEGEEDEDEVS;DEEDEDGEEEEFDDEEDEDED;DEVSGEEEEFGHDEDDEDEDEDEE;DGEEEEFDDEEDEDEDE;EDEDEEEE;EDEEGEDEEDEEDEDG;EDGEEEEFDDEEDEDEDED;EDGEEEEFDDEEDEDEDEDVEG;EEDEDGEEEEFDDEE;EEDEDGEEEEFDDEEDEDEDED;EEEFGHDEDDEDE;EEFDDEEDEDEDEDV;EEFDDEEDEDEDEDVEG;EGEEDEDEVSGEEEEFGHDE;EVSGEEEEFGHDEDDEDEDEDEE;FGHDEDDEDEDEDEEEEESG;FLSLINVGLISVSNLPKLPKLKKL;GEEDEDEVSGEEEEFGHDEDDEDED;GEEEEFDDEEDE;GEEEEFDDEEDEDEDEDVE;GEEEEFGHDEDDEDEDEDE;GHDEDDEDEDEDEEEEE;GVDEEEEDEEGEDEEDEE;GVDEEEEDEEGEDEEDEEDE;HDEDDEDEDEDEEEE 25 38.7 0.13274 0.82539 9.19362 6.87098 7.74913 7.64969 5.33582 5.70683 8.47257 4.2345 0 6.14452 9.94048 4.94312 0 7.48543 8.90557 A0A8I3MS71 A0A8I3MS71_CANLF Homeobox domain-containing protein LOC487079 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" QGNAERLSVSSDD;WDTWVAQRLSVCLQ 2 8.6 0.98647 -0.38857 0 10.0778 0 0 0 0 0 0 0 11.1399 0 0 0 0 0 A0A8I3MS88 A0A8I3MS88_CANLF Kinesin family member 1C KIF1C Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DSDKRSCEESWRLISSLREQLPP;EDPAFRRGRLR;IVFTQRCHDQLTGLDSEKEGANINK;PLSSWERVSRLME 4 6.3 0.99712 -0.10657 0 0 7.9225 8.83235 9.28063 0 0 6.95292 0 8.71418 7.44915 0 0 0 10.0327 A0A8I3MS92 A0A8I3MS92_CANLF SFI1 centrin binding protein C2H1orf167 Canis lupus familiaris (Dog) (Canis familiaris) AAALVARGRRQL;GGGDQPPARRALRGGRP;LRRWHLKWAWRVWRRRVLQLRVA;QEKARNIV;RVWRRRVLQLRVAQRLQQQ;SHSLAWCAV;TLQQKQGQPP;VQAPAQEQGRGS 8 6.7 0.99908 -2.9288 0 5.89331 11.2942 0 0 0 0 8.35407 10.3292 11.1572 0 4.18919 9.77956 0 0 A0A8I3MS93 A0A8I3MS93_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLAALGAHVGLL;GVGLLARVRALVLRERREVAEALL;LALAAVKGLLAGVHAQVVHQ;PRTSTPPHA;TQQPICNSKGGSGGDSTWCSTGET;VGLLARVRALVLRERR 6 13.3 0.97348 0.041303 0 0 0 0 0 0 6.68173 0 0 0 0 0 0 0 0 A0A8I3MSA0 A0A8I3MSA0_CANLF "KH RNA binding domain containing, signal transduction associated 1" KHDRBS1 Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of translational initiation [GO:0045948]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; T cell receptor signaling pathway [GO:0050852]" cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; protein tyrosine kinase binding [GO:1990782]; SH2 domain binding [GO:0042169]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591] GVPPPPTVRGAPAPR;PPPAPETYEEYGYDDTY;PVKQYPKF;QRIPLPPP 4 10.4 1.0022 -1.3613 0 10.8745 0 0 0 0 0 0 0 0 0 0 5.73734 0 0 A0A8I3MSA5 A0A8I3MSA5_CANLF Fibronectin type III and SPRY domain containing 2 FSD2 Canis lupus familiaris (Dog) (Canis familiaris) DEIHKNMFKLE;EQRPRMAGAHRD;GDGSEWDAELVDGSSPHLEVW;SYTVELTQAETPEP;VEQLMGSINTIPAPSAPVIN;VVRSERKTLAKEPLPS 6 13.6 0.99101 -0.29406 0 8.25233 0 8.64303 0 0 0 0 0 0 0 4.40334 0 9.70073 9.66606 A0A8I3MSA7 A0A8I3MSA7_CANLF NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR Canis lupus familiaris (Dog) (Canis familiaris) cellular organofluorine metabolic process [GO:0090346]; electron transport chain [GO:0022900] endoplasmic reticulum membrane [GO:0005789] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958] CMATYGEGDPTDNAQDF;GGGAHGHGPAVTDRAEPP;GVKYAVFGLGN;LGNKTYEHFNAMG;MEHAQAVDYIKKLMTKGRYS;PRSGGPDPV 6 8.9 1.0023 -1.1732 10.7224 0 9.7128 0 0 0 10.936 0 0 8.56434 6.34951 14.0703 10.1623 0 0 A0A8I3MSC7 A0A8I3MSC7_CANLF Phosphoglucomutase 2 PGM2 Canis lupus familiaris (Dog) (Canis familiaris) glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980] cytosol [GO:0005829] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973] ETLTGFKWMGNRAKQLI;FCRYLEKQFSDLKQ 2 5 0.9909 -0.20955 0 0 7.82534 11.3608 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MSE4 A0A8I3MSE4_CANLF Chromosome 17 open reading frame 114 C17orf114 Canis lupus familiaris (Dog) (Canis familiaris) DPNPSPAPAPTVAEGGT;GLKWAWCFPWCGC 2 37 0.99065 -0.51526 0 14.2085 0 0 10.3606 0 0 0 0 0 0 0 0 0 0 A0A8I3MSF1 A0A8I3MSF1_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2" SMARCA2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] SWI/SNF complex [GO:0016514] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; histone binding [GO:0042393]; hydrolase activity [GO:0016787] AVATWHAN;DALTEKQW;DLQAQDRAHRIGQQNE;DSEESDSDYEEEDEEEES;EDESNEEEEEEDEEESES;EEESEDESNEEEEEEDEEESE;EESEDESNEEEEEEDEEESESEA;EETILIIRRLHKV;ESDSDYEEEDEEEES;EYLNSILQHAKD;GGGPTPPQMPPSQP;GYMSPHPSPLGA;KEKKKRRRRKKKAEE;KKRRRRKKK;KKRRRRKKKAE;LKALRLLNFQRQLRQ;PQLRSGKFNVLLTT;PVEILQEREYRLQARIAH;SDSEESDSDYEEEDEEE;SEESDSDYEEEDEEEESSRQD;TAKQDVDDEYSMQ;TILIIRRLHKVLRPFL;VAPRSDSEESD;VLRPFLLRRLKK;YEYIIKDKHILAKV 25 15.9 1.0008 -2.7498 7.94918 4.9632 7.5238 0 6.97074 6.86888 13.2125 7.36054 0 11.8498 6.03639 11.6455 5.16916 9.65735 5.22439 A0A8I3MSF3 A0A8I3MSF3_CANLF Divergent-paired related homeobox DPRX Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" SLVYTDHPIPSFQLSICS 1 10.2 0.97773 0.048313 0 0 6.02797 0 0 0 0 0 0 0 0 0 0 0 6.82934 A0A8I3MSF5 A0A8I3MSF5_CANLF Angiopoietin like 3 ANGPTL3 Canis lupus familiaris (Dog) (Canis familiaris) artery morphogenesis [GO:0048844]; cell-matrix adhesion [GO:0007160]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fatty acid metabolic process [GO:0006631]; glycerol metabolic process [GO:0006071]; lipid storage [GO:0019915]; phospholipid catabolic process [GO:0009395]; phospholipid homeostasis [GO:0055091]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of lipid catabolic process [GO:0050996]; triglyceride homeostasis [GO:0070328] cell surface [GO:0009986]; early endosome [GO:0005769]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] growth factor activity [GO:0008083]; integrin binding [GO:0005178]; phospholipase inhibitor activity [GO:0004859] KILANGLLQ 1 2 0.99227 -0.27195 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.79032 A0A8I3MSG1 A0A8I3MSG1_CANLF Leukocyte-associated immunoglobulin-like receptor 1 LAIR1 Canis lupus familiaris (Dog) (Canis familiaris) GVSVALFLCVLLL 1 5 0.94241 0.059681 0 5.30972 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MSG4 A0A8I3MSG4_CANLF Apolipoprotein A-I (Apolipoprotein A1) APOA1 Canis lupus familiaris (Dog) (Canis familiaris) adrenal gland development [GO:0030325]; blood vessel endothelial cell migration [GO:0043534]; cholesterol biosynthetic process [GO:0006695]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; endothelial cell proliferation [GO:0001935]; G protein-coupled receptor signaling pathway [GO:0007186]; glucocorticoid metabolic process [GO:0008211]; high-density lipoprotein particle assembly [GO:0034380]; high-density lipoprotein particle remodeling [GO:0034375]; integrin-mediated signaling pathway [GO:0007229]; lipid storage [GO:0019915]; lipoprotein biosynthetic process [GO:0042158]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of very-low-density lipoprotein particle remodeling [GO:0010903]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein stabilization [GO:0050821]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of intestinal cholesterol absorption [GO:0030300]; regulation of protein phosphorylation [GO:0001932]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transport [GO:0051180] endocytic vesicle [GO:0030139]; spherical high-density lipoprotein particle [GO:0034366]; very-low-density lipoprotein particle [GO:0034361] amyloid-beta binding [GO:0001540]; apolipoprotein A-I receptor binding [GO:0034191]; chemorepellent activity [GO:0045499]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; high-density lipoprotein particle binding [GO:0008035]; high-density lipoprotein particle receptor binding [GO:0070653]; identical protein binding [GO:0042802]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] AAIDEATKKLN;AAIDEATKKLNA;AAIDEATKKLNAQ;AARLQALKEGGGASL;AEYHARASEQL;AEYHARASEQLSAL;AEYHARASEQLSALG;AIDEATKKLN;AIDEATKKLNA;AIDEATKKLNAQ;ASEQLSALGEKARPA;ASEQLSALGEKARPALE;ASEQLSALGEKARPALEDL;ASLAEYHA;ASLAEYHARASEQL;ASLAEYHARASEQLSALG;DEATKKLN;DEATKKLNAQ;DEPQSPWDRVK;DEPQSPWDRVKD;DEPQSPWDRVKDL;DEPQSPWDRVKDLA;DEPQSPWDRVKDLAT;DEPQSPWDRVKDLATV;DEPQSPWDRVKDLATVY;DNLEKETEVL;DRVKDLAT;DRVKDLATV;DRVKDLATVY;DRVKDLATVYVDAVKD;DRVKDLATVYVDAVKDSG;DSLSSTVTKL;DSLSSTVTKLREQIG;DSLSSTVTKLREQIGPVTQEF;EASALGKQLNL;EEVELYRQ;EGGGASLAEYH;EGGGASLAEYHA;ESFKVSLLAAIDEATKKLNAQ;FKVSLLAAIDEATKKLNA;FKVSLLAAIDEATKKLNAQ;GASLAEYHA;GASLAEYHARASE;GASLAEYHARASEQL;GGASLAEYH;GGASLAEYHA;GGASLAEYHARA;GGASLAEYHARASEQL;GGASLAEYHARASEQLSAL;GGASLAEYHARASEQLSALG;GGGASLAEYHA;GGGASLAEYHARASEQL;HARASEQLSALGEKA;IDEATKKLN;IDEATKKLNAQ;KQLNLKLLDN;KVAPLGSEL;KVSLLAAIDEATKKLNAQ;LAAIDEATKKLNA;LAAIDEATKKLNAQ;LKEGGGASL;LLAAIDEATKKLNAQ;LNLKLLDN;LRQGLLPVLES;NLEKETEVL;PLGSELREG;PQSPWDRVKDLAT;PVLESFKVSLL;QALKEGGGASL;QLNLKLLDN;RAQLAPYSDD;REQIGPVTQEF;RQEMSKDLEEV;RQKVAPLG;SALGEKARPAL;SALGEKARPALED;SALGEKARPALEDLRQG;SALGEKARPALEDLRQGLLPVLES;SFKVSLLAAIDEATKKLNAQ;SLLAAIDEATKKLNAQ;SLSSTVTKL;TVYVDAVKDSG;VSLLAAIDEATKKLNAQ;VYVDAVKDS;VYVDAVKDSG;VYVDAVKDSGRD;VYVDAVKDSGRDYVAQ;VYVDAVKDSGRDYVAQF;YRQKVAPLG;YRQKVAPLGSEL 90 71.1 0 228.65 16.175 16.1514 16.2478 14.9694 14.7735 15.0648 17.5167 17.5298 17.4907 15.1613 15.43 15.3411 16.1533 16.2564 15.0284 A0A8I3MSH3 A0A8I3MSH3_CANLF LSM14A mRNA processing body assembly factor LSM14A Canis lupus familiaris (Dog) (Canis familiaris) P-body assembly [GO:0033962]; stress granule assembly [GO:0034063] P-body [GO:0000932] mRNA binding [GO:0003729] ADEEDPLGPNCYYDKTK;RERRPTWAEERRLNAE;VGQQFGAVGVAGSS 3 11.1 0.84772 0.15641 0 0 0 0 0 0 0 10.9943 0 0 3.7599 6.86196 0 8.38435 0 A0A8I3MSH9 A0A8I3MSH9_CANLF Cell growth regulator with ring finger domain 1 CGRRF1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654] EDFGTVPRSRYP;EVEPPEEN;VTLYEYSPLF 3 9 1.0019 -1.4338 0 0 0 0 0 0 0 0 0 0 9.90388 0 0 0 0 A0A8I3MSJ2 A0A8I3MSJ2_CANLF Patched 1 PTCH1 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epidermal cell differentiation [GO:0045606]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; response to chlorate [GO:0010157]; signal transduction [GO:0007165]; smooth muscle tissue development [GO:0048745]; somite development [GO:0061053]; spinal cord motor neuron differentiation [GO:0021522]; stem cell proliferation [GO:0072089] apical part of cell [GO:0045177]; caveola [GO:0005901]; cilium [GO:0005929]; Golgi apparatus [GO:0005794]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471] cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119] AVLALEHMF;DRGGGGGS;EAMFNPQLMIQTPKEE;ENKQLPKMWLHYFRDWLQGLQD;LLKPKAKVVVIFLFLGLLGV;TQKVLSFTTTTLDD;VEVVHQSVAP;YKSGELITETGYMDQI 8 7.9 1.0045 -1.1044 0 0 8.47901 0 0 0 0 0 0 0 0 8.19259 0 0 0 A0A8I3MSJ8 A0A8I3MSJ8_CANLF Serpin family B member 12 SERPINB12 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244] cornified envelope [GO:0001533]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] IDQVLHFSE;IKGALSMFV 2 4.3 1.0034 -1.6084 10.3228 0 0 0 0 0 0 11.1002 0 0 0 0 0 0 0 A0A8I3MSK4 A0A8I3MSK4_CANLF Protein O-glucosyltransferase 3 POGLUT3 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation via serine [GO:0018242] endoplasmic reticulum [GO:0005783] UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252] EAMRGVTNDLLSIQGN;ECPEEDPQ;EYCECPEEDP;LVPQPDDNTSMCQC;PIKRNLSDLLEKIKWAK;PVYHEYCE;VRYRIYDTVSAGLKIEVLYG;VTNDLLSIQGNTGPSWINKTE 8 18.1 1.003 -1.719 0 8.3117 0 10.0637 8.84486 0 0 0 7.67264 0 0 0 10.5907 6.68047 3.4268 A0A8I3MSL1 A0A8I3MSL1_CANLF "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4" ST6GALNAC4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] ILLCCWACLPFCP;REESHPSVPYHY;TLGGRTYRTLLQLTKMYPG;VYTFTEHMMAYCDQVFQDE 4 20.9 0.99294 -0.14015 0 0 0 0 0 6.6089 0 12.065 0 0 10.2073 0 0 0 0 A0A8I3MSL9 A0A8I3MSL9_CANLF Potassium channel subfamily K member KCNK6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] AAPALDAF;AELETLREELLRRSPCV 2 8 1.0036 -1.0582 0 0 0 0 0 0 0 0 0 0 8.07205 0 9.35092 0 0 A0A8I3MSM4 A0A8I3MSM4_CANLF Uncharacterized protein JAKMIP1 Canis lupus familiaris (Dog) (Canis familiaris) kinase binding [GO:0019900]; microtubule binding [GO:0008017] CCALSNGAD;NELLKRSRETEVQLK 2 3.8 1.0043 -0.80421 0 0 0 0 4.54319 0 0 0 0 0 0 0 0 0 0 A0A8I3MSM8 A0A8I3MSM8_CANLF Zinc transporter ZIP9 (ZIP-9) (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) SLC39A9 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] zinc ion transmembrane transporter activity [GO:0005385] ALGAAASTSQTSVQ;GGRGLSRLEVAALVLGCLIPLIL;GVAMLFSAGTFL;TDDPETARPSN;VTVLGAGL 5 22.1 0.97859 0.046283 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.80071 A0A8I3MSN7 A0A8I3MSN7_CANLF Zinc transporter ZIP9 (ZIP-9) (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) SLC39A9 Canis lupus familiaris (Dog) (Canis familiaris) intracellular zinc ion homeostasis [GO:0006882]; regulation of cellular response to testosterone stimulus [GO:2000654]; regulation of vascular endothelial cell proliferation [GO:1905562] mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] androgen binding [GO:0005497]; G protein-coupled receptor activity [GO:0004930]; zinc efflux transmembrane transporter activity [GO:0022883] ALGAAASTSQTSVQ;GVAMLFSAGTFL;LPERACHSIKW;TDDPETARPSN;VTVLGAGL 5 17.9 1.0027 -1.8945 4.0205 0 0 0 0 8.83898 0 0 0 0 0 0 6.40669 0 0 A0A8I3MSP2 A0A8I3MSP2_CANLF Zinc finger and BTB domain containing 14 ZBTB14 Canis lupus familiaris (Dog) (Canis familiaris) cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; kidney development [GO:0001822] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDVNLMMSSGQI;QDDSPSDD 2 4.5 1.0025 -1.3993 0 0 0 0 0 0 0 4.81588 0 4.32113 0 0 0 0 0 A0A8I3MSP9 A0A8I3MSP9_CANLF "Unc-79 homolog, NALCN channel complex subunit" UNC79 Canis lupus familiaris (Dog) (Canis familiaris) CLHVISLMEALQECNSTI;DDTEGPENP;DSPSSLWTTISNQ;EGEEEENPATKHGENPGNCTEPMEH;ETSSHSSISKQIQ;EVRLNCMETFEV;LGSLTHNAVCP;NIKHLSAGLQLRLQAIQ;QLRLQAIQNNVNHHS;VLRDAPSERGLQ;VYHCQLLECLMKYKQE;WKDLLYVI 12 6.2 1.0041 -1.9965 0 0 0 9.48706 0 0 9.92129 9.87768 8.09529 10.0385 9.96607 0 9.57922 6.61875 0 A0A8I3MSQ3 A0A8I3MSQ3_CANLF Sodium channel subunit beta-1 SCN1B Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell action potential involved in contraction [GO:0086002]; corticospinal neuron axon guidance [GO:0021966]; locomotion [GO:0040011]; neuronal action potential propagation [GO:0019227]; positive regulation of neuron projection development [GO:0010976]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307] intercalated disc [GO:0014704]; node of Ranvier [GO:0033268]; perikaryon [GO:0043204]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518] sodium channel inhibitor activity [GO:0019871]; transmembrane transporter binding [GO:0044325]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062] AVSSAWGG;GCVEVDSETEAVYGMTFKILCI;IVSEIMMYV 3 17.4 0.98832 -0.26458 0 0 0 0 0 0 0 0 11.4556 0 0 0 0 0 0 A0A8I3MSR7 A0A8I3MSR7_CANLF 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (Protein histidine phosphatase) PHPT1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; lamellipodium organization [GO:0097581]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cell motility [GO:2000147] cytosol [GO:0005829]; leading edge of lamellipodium [GO:0061851]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; protein histidine phosphatase activity [GO:0101006]; transmembrane transporter binding [GO:0044325] YKWAEYHADIYDKVSGDMQK 1 16 0.97284 0.048206 0 0 0 7.34589 0 6.94345 0 5.72566 0 0 0 0 0 0 0 A0A8I3MSS5 A0A8I3MSS5_CANLF Small integral membrane protein 19 SMIM19 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SSLAARRL;YSISRKYDYQQPQNQ 2 13.1 0.99108 -0.13498 0 0 0 0 0 8.33298 0 0 8.8708 0 0 0 0 9.62761 0 A0A8I3MSU9 A0A8I3MSU9_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2A1 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] membrane [GO:0016020] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] EHVTHRVRLYNIQGI;GYSALLLI;IQDAKHRLTLLSAQSLGVS;LDRGHLDYP;QYIFNNMVI;SFLVQIPPLGLK 6 6.6 1.0035 -0.80421 0 0 0 0 8.33275 0 0 0 0 0 0 4.64166 0 0 0 A0A8I3MSX3 A0A8I3MSX3_CANLF LRAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVYCGHGEIIHFEGRN;VELEGSEP 2 11 1.0038 -1.0552 0 0 0 7.12257 0 0 0 0 7.94772 0 0 0 0 0 0 A0A8I3MSX4 A0A8I3MSX4_CANLF Large ribosomal subunit protein uL6 (60S ribosomal protein L9) RPL9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] ELSLLGKKKKRLRV;WGNRKELATVRT 2 13.5 0.91296 0.11121 0 5.83233 0 0 0 0 0 0 0 0 0 0 7.61912 0 0 A0A8I3MSX9 A0A8I3MSX9_CANLF Histamine H1 receptor HRH1 Canis lupus familiaris (Dog) (Canis familiaris) memory [GO:0007613]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; regulation of vascular permeability [GO:0043114]; visual learning [GO:0008542] cytosol [GO:0005829]; plasma membrane [GO:0005886] histamine receptor activity [GO:0004969] PKLMPLVVFLSAISLV;VGNLYIVSLSVAD 2 6 0.98793 -0.48375 0 0 0 0 0 10.2673 0 0 0 0 0 0 0 0 0 A0A8I3MSY3 A0A8I3MSY3_CANLF Matrix metallopeptidase 15 MMP15 Canis lupus familiaris (Dog) (Canis familiaris) collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] FQEVPYEDIRLRRQK;GVGICRGDPGGS;LGLRRRPRPRR;LVAVHELGHA;RALGSTRPRAWTEGAGRAGGAA;RRKRYALTGRKWNNHHL;VLDNYPMPIGHFWR;VLVPPLLLLL;WPFKSGGPGAR;YFYKGTKYWK 10 13.1 1.0028 -1.388 10.0441 7.36859 0 0 0 5.94601 10.8516 0 10.9879 0 0 0 0 0 7.48639 A0A8I3MSY8 A0A8I3MSY8_CANLF Profilin PFN1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074] cell cortex [GO:0005938]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634] "actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphotyrosine residue binding [GO:0001784]; proline-rich region binding [GO:0070064]; small GTPase binding [GO:0031267]" ITVTMTAKTLV 1 7.9 0.98371 -0.24209 0 0 0 0 0 0 0 13.5338 13.5269 0 0 0 0 0 0 A0A8I3MSY9 A0A8I3MSY9_CANLF Delta like non-canonical Notch ligand 1 DLK1 Canis lupus familiaris (Dog) (Canis familiaris) QCICDDGWDGNLCDIGW 1 12.9 0.98514 0.046227 0 0 0 0 9.28653 0 0 0 0 0 4.55115 0 0 0 0 A0A8I3MSZ4 A0A8I3MSZ4_CANLF Olfactory receptor OR5AQ1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] GVIAMFTFTIIMV;SFCDICYSTVFAPKM;YIQPSSQY 3 11.6 0.99638 -0.57335 0 0 0 0 0 0 0 0 0 0 0 0 9.66099 0 0 A0A8I3MSZ8 A0A8I3MSZ8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF167 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] zinc ion binding [GO:0008270] RGPGDEEEEEETQ 1 3.7 0.94159 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 8.39763 0 0 A0A8I3MSZ9 A0A8I3MSZ9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HSRLTQHHSI;LDSVLPQRHGMRT;QEEWTCLNRTQRKLYRDVMLEN;QPGNMFCQGPRL 4 7.4 0.98682 -0.41893 7.54921 9.79593 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MT06 A0A8I3MT06_CANLF 14-3-3 protein gamma YWHAG Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein targeting [GO:0006605]; regulation of neuron differentiation [GO:0045664]; regulation of synaptic plasticity [GO:0048167]; signal transduction [GO:0007165] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; phosphoserine residue binding [GO:0050815]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; protein sequestering activity [GO:0140311] KNVVGARR;QLVQKARLAEQAE;VLSLLDNYLIKNCSETQYESKVFY;YSVFYYEIQ 4 21.9 0.98798 -0.48925 0 8.41363 9.60731 0 0 0 0 0 13.2936 0 13.0212 0 0 0 0 A0A8I3MT14 A0A8I3MT14_CANLF Uncharacterized protein ZNF599 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AVTFTGEEW;KLSEMQEGSLRTGTDPHKETCTRKL;RHQQIHAG 3 7.2 1.0034 -1.5807 3.10998 0 0 0 5.39859 10.033 0 0 0 0 0 0 0 9.85356 3.33242 A0A8I3MT33 A0A8I3MT33_CANLF SPARC related modular calcium binding 1 SMOC1 Canis lupus familiaris (Dog) (Canis familiaris) eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667] extracellular region [GO:0005576] calcium ion binding [GO:0005509] GVVHRGRCKDAG;KVISLPELKGCLGVSKEGG;SHTLEERVVRWY 3 9.5 0.98562 -0.43239 0 0 8.14241 0 0 0 7.38431 0 0 0 0 0 0 0 0 A0A8I3MT35 A0A8I3MT35_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2K Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] DLVDENFTE;PDTPYEGGRYQLEIKIPE 2 17.2 1.0027 -0.7559 0 9.1902 0 0 0 0 0 0 7.50096 0 0 0 0 0 0 A0A8I3MT38 A0A8I3MT38_CANLF FXYD domain-containing ion transport regulator FXYD1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; T-tubule [GO:0030315] sodium channel regulator activity [GO:0017080] IGGLIIAGILFILGILIVLSE 1 24.4 0.97509 0.047166 0 0 0 0 0 0 0 0 0 0 0 7.85375 0 0 0 A0A8I3MT54 A0A8I3MT54_CANLF Elongation factor like GTPase 1 EFL1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] ACSSKGKNQ;CFLHITPESGKQDL;DTAPVIIF;IDFRFFFKDFIYLFMRDREREWQRH;MFIIKAVLPV;SDLIRSMEQLTSSLNE;THLHTRLRYMDSR 7 7.7 1.0015 -2.6695 7.70432 0 0 0 0 0 0 8.94448 9.00509 0 6.20285 0 0 0 8.72072 A0A8I3MT62 A0A8I3MT62_CANLF Coiled-coil domain-containing protein 181 CCDC181 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; manchette [GO:0002177]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] DENKDMDSKESGE;DPISDSDSENSFQ;RAFKQWLRRKRIE 3 7.7 0.86602 0.17908 0 0 0 4.5744 0 4.67005 0 0 0 0 0 7.60437 0 0 0 A0A8I3MT63 A0A8I3MT63_CANLF DNA mismatch repair protein MSH2 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] MutSalpha complex [GO:0032301] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] AFKASPGNLSQFED;EMSEENITMKLKQLK;ESAAEVGFVRFF;FHELTALA;HVIECAKQKALEL;SELREIMDDLEKK 6 8.5 0.98943 -0.26403 0 0 0 0 0 0 0 11.7573 0 0 0 0 0 0 0 A0A8I3MT69 A0A8I3MT69_CANLF Methylcytosine dioxygenase TET (EC 1.14.11.80) TET1 Canis lupus familiaris (Dog) (Canis familiaris) 5-methylcytosine catabolic process [GO:0006211]; cellular response to reactive oxygen species [GO:0034614]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; dendrite morphogenesis [GO:0048813]; epigenetic programing of male pronucleus [GO:0044727]; inner cell mass cell differentiation [GO:0001826]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827] chromosome [GO:0005694]; nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; iron ion binding [GO:0005506]; methyl-CpG binding [GO:0008327]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] DSYPDPIKSERDCYPTSS;EDNRSLGVIPQDEQLHVLPLYKLS;ELKKKPSVIVPLEVIKE;FGCSWSMYFNGCK;IWIASKFQRFGQFGP;LSRRLSQPPVIIAKPKKV;LTENLKSYNGHPTDRRCTLNE;NMNNGSTVV;SLLSLMKDR;SLLTKQKNTT;SQGITQLSQAGPSTLE;VYSSQVQP 12 8.3 1.0031 -2.125 12.5271 0 0 0 5.70512 0 0 8.23616 8.30122 0 0 11.3101 11.2021 0 0 A0A8I3MT76 A0A8I3MT76_CANLF AE binding protein 1 AEBP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] EATEATPAGWEES;EDDYYDGAWCAE;EEEDEEGV;ESETETYT;HYDDMDYYFGPP;LESETREDDL;LSSVASPPGAAEPAGA;MNGNRPIPHIDPS;NHGVKTASGGD;YEDFPDLNSVL 10 8.3 1.0023 -2.5894 0 0 0 0 7.54797 9.13209 11.9652 10.7784 0 0 0 0 6.41087 0 0 A0A8I3MT84 A0A8I3MT84_CANLF Interleukin 21 receptor IL21R Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] GVVSIDTV;LLLVIILPILVFLGLKI;LLYLLLVIILPILVFL;LVFLGLKIHLPWRLWKKV;TYLLYLLLVIILPILVFLGLKIHLP;YLLYLLLVIILPI;YYCCPAQSASKGL 7 9.8 1.0027 -1.1272 0 0 4.99068 0 5.73314 5.17225 8.96749 0 0 0 0 6.25261 0 0 10.5419 A0A8I3MT98 A0A8I3MT98_CANLF Large ribosomal subunit protein mL46 MRPL46 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LQEEMAALFQQIE;QLGTHAAQQ;TVLGVAKGWRRLEGLR 3 13 0.98351 -0.2444 0 0 0 9.65937 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MTA4 A0A8I3MTA4_CANLF Transmembrane protein 232 TMEM232 Canis lupus familiaris (Dog) (Canis familiaris) ACLKALMELMRDF;KDSVKKRVLRVTVRILK;KKRVLRVTVRILKSVRRTYTFELK;SITKEFIVRFNQT;SYKNIDAEMEHLQ;VKKRVLRVTVRILKSVRRTYTF;YLKKKDSVKKRVLRVTVR;YYGLMYNLVKMSWELRGD 8 14 0.99406 -0.05622 0 0 0 0 0 0 6.94486 0 12.4864 4.51772 7.04854 0 0 7.77992 5.81691 A0A8I3MTB4 A0A8I3MTB4_CANLF Tetratricopeptide repeat domain 9B TTC9B Canis lupus familiaris (Dog) (Canis familiaris) PPALSPPG 1 3.4 0.99009 -0.26592 0 0 0 0 0 0 0 10.4767 0 0 0 0 0 0 0 A0A8I3MTB6 A0A8I3MTB6_CANLF Histone deacetylase (EC 3.5.1.98) HDAC9 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to insulin stimulus [GO:0032869]; cholesterol homeostasis [GO:0042632]; negative regulation of cytokine production [GO:0001818]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] histone deacetylase binding [GO:0042826]; histone H4K16 deacetylase activity [GO:0034739]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] ETETVSALASLTVD;KYLRDQLNISKILIV;LLIQQQQQIQK;SKYWKSVRMVAVPR 4 4.6 0.99271 -0.16546 0 8.14629 0 0 0 6.92695 0 0 0 0 0 0 0 0 0 A0A8I3MTB8 A0A8I3MTB8_CANLF KIAA0513 KIAA0513 Canis lupus familiaris (Dog) (Canis familiaris) VGTLIDFGTEPSASSPLE 1 6 0.97487 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.59304 A0A8I3MTC0 A0A8I3MTC0_CANLF Deubiquitinase DESI2 (EC 3.1.2.22) (EC 3.4.19.12) (Desumoylating isopeptidase 2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (Protein FAM152A) (S-depalmitoylase DESI2) DESI2 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytoplasm [GO:0005737] deubiquitinase activity [GO:0101005] NEYTSSIGIGVFHS;VEELGKEYKGNAY 2 16.8 0.99492 -0.083067 0 0 0 0 0 0 10.4746 0 9.74512 0 0 0 0 0 0 A0A8I3MTC6 A0A8I3MTC6_CANLF LIM domain binding 3 LDB3 Canis lupus familiaris (Dog) (Canis familiaris) AVCHVNLEGQP;DMSGSPTARSPGPL;DTCFICAVCH;EADEWARRSSNLQS;IVQRAERFPASSRTPLCG;LAVDSASPV;LFHMEDGEPYCE;LRQTWHTTCFVC;SAAAACAAAATPASSPADSP 9 17.6 1.0025 -0.71817 0 6.36777 0 0 10.7712 0 7.81654 8.30076 0 8.47646 9.57145 0 15.6353 8.28753 7.16672 A0A8I3MTE1 A0A8I3MTE1_CANLF RRM domain-containing protein LOC119879793 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U1 snRNP [GO:0005685] U1 snRNA binding [GO:0030619] IYINNMNDKINKEEL 1 6.7 0.95318 0.053887 0 0 0 4.62193 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MTF8 A0A8I3MTF8_CANLF Ras-related GTP-binding protein RRAGD Canis lupus familiaris (Dog) (Canis familiaris) cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of autophagy [GO:0010507]; positive regulation of TORC1 signaling [GO:1904263] centrosome [GO:0005813]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleoplasm [GO:0005654] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982] PTLENLLNIFISNSGIEKA;VIDSQDDYM 2 7.1 1.0042 -0.80421 0 3.27517 0 7.77538 0 0 0 0 0 0 0 0 4.75937 3.87725 0 A0A8I3MTH5 A0A8I3MTH5_CANLF E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) PRKN Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; positive regulation of metabolic process [GO:0009893]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CKEEYHEGECST;GDGPRKAVEGSD;HVVQRPWSKSQ;LDCFYLYCVTRLNDRQFIY;LNDRQFIYDPQ;TCSCEWNRTCMGDHWFDV;VPVEKNGGCMHM 7 20 0.93554 0.065379 0 0 0 8.17632 5.88242 8.43779 0 0 5.66957 0 0 0 0 10.6348 9.50557 A0A8I3MTI3 A0A8I3MTI3_CANLF NOP9 nucleolar protein NOP9 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] LQRLLDAITTR;SEVCDDFL 2 3 1.0031 -1.3346 0 0 0 0 0 0 0 0 10.1783 0 0 0 0 10.5667 0 A0A8I3MTI5 A0A8I3MTI5_CANLF Microtubule crosslinking factor 1 MTCL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] extracellular space [GO:0005615]; membrane [GO:0016020] protein homodimerization activity [GO:0042803] APSPARPFLKDLHGRTPAPG;DTKGGPSEHVL;EEMRDSYLEE;ELVPDLQS;FEPRPEPGWL;GVRVLHSPP;LAPKGCSESAWARSTTT;PHLTESSSFLSTVTSVSRDSPVGN;QMEEEGEDFTESEH;RAAGGAKA;RQDLSAPPGYTF;SPLPHLTESSSFL;TDTMTSPEHCQKQP;VEEKRAKAEDENESL 14 8.6 0.99904 -3.2426 13.7093 9.07414 7.98834 10.1248 9.48726 8.62084 12.0805 0 0 9.67156 8.27361 7.01056 10.4453 0 6.29042 A0A8I3MTJ0 A0A8I3MTJ0_CANLF Chromosome 11 open reading frame 71 C11orf71 Canis lupus familiaris (Dog) (Canis familiaris) MAVNFVSLWAGVQ 1 11.2 0.94158 0.070839 0 0 0 0 0 0 0 0 6.28779 0 0 0 0 0 0 A0A8I3MTK2 A0A8I3MTK2_CANLF SH2B adaptor protein 2 SH2B2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; B cell receptor signaling pathway [GO:0050853]; B-1 B cell homeostasis [GO:0001922]; brown fat cell differentiation [GO:0050873]; cytokine-mediated signaling pathway [GO:0019221]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; regulation of metabolic process [GO:0019222] actin filament [GO:0005884]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725] SH2 domain binding [GO:0042169]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] HYSEPEPSSGEEAS;PKVSIPLSAIIEVRTT;SSWETPPSL 3 4.3 0.99208 -0.20853 0 0 0 8.14175 0 0 6.91504 0 0 0 0 0 0 0 0 A0A8I3MTL2 A0A8I3MTL2_CANLF V-type proton ATPase subunit a ATP6V0A4 Canis lupus familiaris (Dog) (Canis familiaris) "vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" GAEDDHEE;GELGLVQFKDLNVNVSSFQ;ILRANHRKSL;MELSGSSMVP;NPYLQLDPAIPGVYSGNP;TVITQTESHRQR;VGSYREINPAPY 7 11.6 1.0018 -1.2073 9.79168 0 0 0 0 10.9276 0 6.79481 0 0 0 2.50698 0 0 0 A0A8I3MTL7 A0A8I3MTL7_CANLF Neuronal growth regulator 1 NEGR1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; positive regulation of neuron projection development [GO:0010976] plasma membrane [GO:0005886]; side of membrane [GO:0098552] GVPPPAFEW;TDDGPYTCSVQT;VLGTKIMLSKKKKKIMLSSIFI;VLSLVICRCYLEDGASKGAWLN 4 15.6 0.99207 -0.29476 0 0 0 0 12.6465 0 0 0 0 5.40201 6.28014 0 6.85375 0 0 A0A8I3MTL8 A0A8I3MTL8_CANLF Small ribosomal subunit protein RACK1 RACK1 Canis lupus familiaris (Dog) (Canis familiaris) gastrulation [GO:0007369]; positive regulation of protein phosphorylation [GO:0001934]; rescue of stalled ribosome [GO:0072344] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribosome [GO:0005840] protein kinase C binding [GO:0005080]; ribosome binding [GO:0043022]; translation regulator activity [GO:0045182] QFPDMILSASR 1 12.8 0.99139 -0.13446 0 0 0 0 0 0 0 0 0 0 20.1252 0 0 0 0 A0A8I3MTM5 A0A8I3MTM5_CANLF Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) CIAO1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; MMXD complex [GO:0071817] GHQRTVRKVAW 1 3.2 0.98896 -0.2606 0 0 0 0 0 0 0 0 9.74957 0 0 0 0 0 0 A0A8I3MTM7 A0A8I3MTM7_CANLF Receptor tyrosine kinase like orphan receptor 1 ROR1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron projection development [GO:0010976]; Wnt signaling pathway [GO:0016055] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; Wnt-protein binding [GO:0017147] PPPLLALLPAALLLLLLAAR;PSLCHYAFPYCDETS 2 3.7 0.97496 0.048206 0 6.23291 0 0 0 0 7.19229 0 0 0 0 0 0 0 0 A0A8I3MTN8 A0A8I3MTN8_CANLF Derlin DERL2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; proteasomal protein catabolic process [GO:0010498] Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839] misfolded protein binding [GO:0051787]; ubiquitin-specific protease binding [GO:1990381] ITPFQLYFNPELIFKHFQIWRLI;PDEDPNYN;SLVFLGQAFTIML 3 18.4 1.0021 -0.98842 0 6.39038 0 0 0 8.14858 0 0 0 0 0 6.79116 0 0 0 A0A8I3MTN9 A0A8I3MTN9_CANLF SERTA domain containing 3 SERTAD3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell growth [GO:0030308]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] EDEKWDWGPAG 1 5.6 0.97858 0.035491 0 0 0 0 0 0 0 0 9.72584 0 0 0 0 0 0 A0A8I3MTP4 A0A8I3MTP4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] PLLLLPLLWGVRSL;QEDAEYELRVQESVTVQ 2 8.4 0.99399 -0.1593 0 0 0 0 0 0 0 0 10.2687 0 0 0 10.0791 0 0 A0A8I3MTP8 A0A8I3MTP8_CANLF Protein unc-93 homolog A UNC93A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALGFVIAFGYSTFL;GAAPLWSAQCTYL;LLRDKRLRLLV;VGYVMICFSATNSLC 4 12.8 0.80446 0.2111 0 0 4.6357 0 0 0 6.22691 0 9.49512 6.72301 0 0 0 0 0 A0A8I3MTQ3 A0A8I3MTQ3_CANLF WD repeat domain 64 WDR64 Canis lupus familiaris (Dog) (Canis familiaris) CEIFGYFSSEED;DDMYLMVI;DWKEEEHWL;ESGFLFAT;LKRNLVPQINLTSFF;LPEGKDWKEEEH;LSSPKIRRCALE;TGGGGRAG 8 6.6 1.0022 -2.5933 7.7974 0 8.94266 0 9.85215 0 11.4342 0 0 0 0 0 9.08505 0 9.35982 A0A8I3MTR0 A0A8I3MTR0_CANLF Trafficking protein particle complex subunit TRAPPC3L Canis lupus familiaris (Dog) (Canis familiaris) Golgi vesicle transport [GO:0048193] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008] NNSSRTEFSLILDKNPLVE 1 10.5 0.95425 0.049463 0 0 0 0 0 0 0 0 5.97019 0 0 0 0 0 0 A0A8I3MTS8 A0A8I3MTS8_CANLF Paired box 7 PAX7 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HYPDIYTREELAQRTKLTEARVQVW;IVEMAHHGIRPCVI;TTTISQDGGSTV 3 10.1 0.99302 -0.28056 0 0 0 0 0 0 0 0 0 0 4.54541 0 0 0 0 A0A8I3MTT0 A0A8I3MTT0_CANLF Metallophosphoesterase 1 (Post-GPI attachment to proteins factor 5) MPPE1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081] HKLNCSREHFPLYRSSD;SSQGWADD 2 6.8 1.002 -1.3633 0 9.84551 0 0 0 0 5.90525 0 0 0 0 0 0 0 0 A0A8I3MTU5 A0A8I3MTU5_CANLF Heterogeneous nuclear ribonucleoprotein U HNRNPU Canis lupus familiaris (Dog) (Canis familiaris) "adaptive thermogenesis [GO:1990845]; cardiac muscle cell development [GO:0055013]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to leukemia inhibitory factor [GO:1990830]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; dosage compensation by inactivation of X chromosome [GO:0009048]; maintenance of protein location in nucleus [GO:0051457]; mRNA metabolic process [GO:0016071]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to spindle microtubule [GO:1902889]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of chromatin organization [GO:1902275]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic spindle assembly [GO:1901673]; RNA localization to chromatin [GO:1990280]" catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; inactive sex chromosome [GO:0098577]; kinetochore [GO:0000776]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; mitotic spindle midzone [GO:1990023]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; RNA polymerase II transcription regulator complex [GO:0090575]; telomerase holoenzyme complex [GO:0005697] actin binding [GO:0003779]; ATP binding [GO:0005524]; chromatin DNA binding [GO:0031490]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(C) RNA binding [GO:0017130]; poly(G) binding [GO:0034046]; pre-mRNA binding [GO:0036002]; promoter-specific chromatin binding [GO:1990841]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; snRNA binding [GO:0017069]; telomerase RNA binding [GO:0070034]; TFIIH-class transcription factor complex binding [GO:0001097]; transcription corepressor activity [GO:0003714] AALDGDQMELGEE;DQGFQEGEDELGDEEEG;EDYGEKFDEND;EEEAASEDENGDDQGFQEGEDE;EFNFGQKEKP;EQKGGDKKRGVKRPREDHGRGY;GGGGGGSG;GRGNNRGYKNQ;GVRSVLMLNQQKEAILNLQN;PQPPATPQQ;SEDENGDDQGFQE;TQKKAEVEG 12 16.9 1.0019 -1.4181 0 7.94492 13.4479 7.29186 0 5.47346 10.7094 0 0 0 8.71785 0 0 0 0 A0A8I3MTU9 A0A8I3MTU9_CANLF LY6/PLAUR domain containing 1 LYPD1 Canis lupus familiaris (Dog) (Canis familiaris) side of membrane [GO:0098552] DEPQNRGGVCERNR 1 5.6 0.98424 -0.24778 0 0 0 0 0 0 0 10.2345 0 0 0 0 0 0 0 A0A8I3MTW8 A0A8I3MTW8_CANLF Angiopoietin like 7 ANGPTL7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of vasculature development involved in avascular cornea development in camera-type eye [GO:1901346]; regulation of extracellular matrix organization [GO:1903053] extracellular region [GO:0005576] identical protein binding [GO:0042802] ELEVFCDMETA;FYRDWKQYKQGFGS;VSVVMQVMELE;YKLPPDDFLGSPELE 4 14 0.98802 -0.49409 0 0 0 0 8.95134 0 10.246 0 0 0 0 10.4706 10.7983 0 0 A0A8I3MTW9 A0A8I3MTW9_CANLF Scavenger receptor cysteine rich family member with 4 domains SSC4D Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVGALPSREMALFTTATWASGKK;SVCDDDWDVVDANV;VGGPGPCRGRVEVM;VKCRGDESALLLCSHIR 4 11.8 0.98633 -0.45416 0 0 0 0 9.81404 0 6.83264 0 11.2493 0 0 0 0 0 0 A0A8I3MTX4 A0A8I3MTX4_CANLF Matrix metallopeptidase 19 MMP19 Canis lupus familiaris (Dog) (Canis familiaris) collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] GSVHFDEDELWTER;IMLGPRGKTYAFK;TAVDYLLQYGYLQ 3 7.3 0.99014 0.014693 9.52009 8.72734 9.43183 0 9.61699 0 0 10.7866 11.5256 0 0 9.57552 9.90456 0 9.98285 A0A8I3MTY4 A0A8I3MTY4_CANLF DNA damage-inducible transcript 4 protein DDIT4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of signal transduction [GO:0009968] mitochondrion [GO:0005739] LDGVSLPDFEL;TRGGPGRWEGPALEGVSAALAP 2 5.5 0.9879 -0.48866 0 0 0 0 10.6648 0 0 0 0 0 0 0 0 0 0 A0A8I3MU00 A0A8I3MU00_CANLF Ring finger protein 31 IRF9 Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PGVCWDDAAKT 1 2.7 0.97975 0.035491 7.99328 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MU20 A0A8I3MU20_CANLF Microfibril associated protein 3 MFAP3 Canis lupus familiaris (Dog) (Canis familiaris) interleukin-15-mediated signaling pathway [GO:0035723]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; T cell activation [GO:0042110] external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121] MHC class II protein binding [GO:0042289]; protein tyrosine kinase binding [GO:1990782] KSIDTDSQDSS 1 3 0.98008 0.035491 4.27068 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MU29 A0A8I3MU29_CANLF E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2) RNF2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; PcG protein complex [GO:0031519]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KVNKPMELYYA 1 4.2 0.99156 -0.18223 0 10.6379 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MU35 A0A8I3MU35_CANLF Amino acid transporter SLC1A3 Canis lupus familiaris (Dog) (Canis familiaris) L-alpha-amino acid transmembrane transport [GO:1902475] plasma membrane [GO:0005886] symporter activity [GO:0015293] GVRKRTLLAKRKVQNITKE;NMFPPNLVEACFKQ;VGLLIHAVIVL;VGLLIHAVIVLPLLYFLV;VIGGQLAMYTVTV;VIVLPLLYFLV 6 12.9 0.9304 0.10749 0 6.11449 0 0 14.7632 4.0115 5.89533 4.97957 0 0 0 0 0 0 0 A0A8I3MU46 A0A8I3MU46_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal snRNP assembly [GO:0000387] pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RSRIQMWLYKQ 1 20 0.98426 -0.25342 9.45566 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MU52 A0A8I3MU52_CANLF "Mal, T cell differentiation protein 2" MAL2 Canis lupus familiaris (Dog) (Canis familiaris) myelination [GO:0042552] membrane raft [GO:0045121] structural constituent of myelin sheath [GO:0019911] GAFLLEAAATSL 1 6.8 0.95252 0.05044 0 0 0 0 0 0 0 0 0 9.7322 0 0 0 0 0 A0A8I3MU58 A0A8I3MU58_CANLF Gamma-synuclein SNCG Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; protein secretion [GO:0009306]; regulation of dopamine secretion [GO:0014059]; regulation of neurotransmitter secretion [GO:0046928]; synapse organization [GO:0050808] axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; synapse [GO:0045202] GVVRKEDLE 1 7.1 0.9829 -0.25212 0 9.67188 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MU67 A0A8I3MU67_CANLF Olfactory receptor LOC119864989 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIYGVRTKQIRERVLRIFF;GVRTKQIRERVLRIFF 2 6.1 0.93323 0.098643 0 0 0 0 0 0 0 6.371 0 0 0 0 0 6.6057 0 A0A8I3MU77 A0A8I3MU77_CANLF Metallothionein 1E LOC100686073 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] DCSCSTGGSCTCAGSC;DPDCSCSTGGSC;GRGGEGGEDPGAGGPEHPGPGPAA 3 17.2 0.87744 0.14098 5.81222 0 0 0 0 3.36667 0 0 0 0 0 7.17672 0 0 0 A0A8I3MU79 A0A8I3MU79_CANLF Taxilin alpha TXLNA Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113] cytoplasm [GO:0005737] syntaxin binding [GO:0019905] EEKLAALCKK;QAQEMLKEAEERHQ;VFTTFKQEME 3 6.1 0.99317 -0.19126 0 0 0 0 0 0 9.90504 0 0 0 0 0 0 0 0 A0A8I3MU83 A0A8I3MU83_CANLF Galanin receptor 3 GALR3 Canis lupus familiaris (Dog) (Canis familiaris) "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; galanin-activated signaling pathway [GO:0090663]; positive regulation of transcription by RNA polymerase II [GO:0045944]" membrane [GO:0016020]; non-motile cilium [GO:0097730] galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046] APYLSYYGTVRYGALE 1 4.3 0.67532 0.27459 0 0 0 0 0 0 10.5578 0 12.4853 0 0 0 0 12.5216 0 A0A8I3MU85 A0A8I3MU85_CANLF Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane organization [GO:0007006]; protein import into mitochondrial matrix [GO:0030150]; release of cytochrome c from mitochondria [GO:0001836] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] cysteine-type endopeptidase activator activity [GO:0140608]; interleukin-2 receptor binding [GO:0005134]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; ribonucleoprotein complex binding [GO:0043021] DDPLEAFKQRQ;GVLLHPEWSLATGWRF;KEPYYQPPYTLV 3 11 0.98726 -0.46366 0 0 0 0 0 0 11.5988 0 0 0 0 0 0 0 0 A0A8I3MU97 A0A8I3MU97_CANLF DNA-directed RNA polymerase subunit POLR1F Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] RNA polymerase I complex [GO:0005736] AAACALVSSRYSCLV;EIIEKPLKKKKKKKDP;LVSSRYSCLVAGP 3 10.2 0.98554 -0.44153 0 0 0 0 10.3556 0 0 0 14.1519 0 0 0 0 0 0 A0A8I3MUA9 A0A8I3MUA9_CANLF Basonuclin 1 BNC1 Canis lupus familiaris (Dog) (Canis familiaris) DPKQEIHGPFPS;EDEPEACSP;GLENYNSGPPSE;PDCRPLPGYAAPGD;SPATPAEL 5 5.7 1.0026 -1.1271 0 0 0 0 7.71918 5.05076 0 0 0 8.71132 10.3997 0 9.85014 0 0 A0A8I3MUB0 A0A8I3MUB0_CANLF DUF4590 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AMKFKNSMDNAQ;AQENIFKYEYEEDFEVDE;DAQENIFKYEYEEDFE;EEEPEEGTPVIAEGLSEK;GDGEAHSEN;SSRSHPCSSCSEDESALGDGEA;VEEMELDGKPGQDV;YEYEEDFEVDEE 8 16.9 1.0037 -1.6511 0 0 0 9.73725 0 9.78501 11.2079 0 3.56828 6.14382 8.37972 8.87246 3.89666 4.33714 0 A0A8I3MUB3 A0A8I3MUB3_CANLF Cyclin-C CCNC Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] DSPLVAGPEAAR;EKILEIIRVILKLYE;FLSEEEYWKLQI;LELMDCCL;QWFAELSVDMEK;YARYSLKSID 6 23.8 1.0025 -1.1302 0 10.5192 9.25411 0 0 0 10.8032 11.7532 0 0 0 4.6052 0 0 0 A0A8I3MUC2 A0A8I3MUC2_CANLF Glypican 5 GPC5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] CGRPIRTATQ;DCDDEDGCGG;DCDDEDGCGGSGSGEV;EERYQIAA;GRSPKPDKWELQMGSG;IVKSYTERVVGSG;QVSGDCDDEDGC;RMEERYQIAARQDMQ;TDSSLEYSECIRM 9 15.2 1.003 -2.112 11.1281 3.90699 0 10.8274 0 0 10.1727 0 9.99365 8.20046 0 6.09984 9.51473 5.22913 0 A0A8I3MUC7 A0A8I3MUC7_CANLF "Calcium uptake protein 1, mitochondrial" MICU1 Canis lupus familiaris (Dog) (Canis familiaris) calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560] mitochondrial intermembrane space [GO:0005758]; uniplex complex [GO:1990246] calcium ion binding [GO:0005509] DGEVDMEEFEQV;ELSDHVCDVVFALFDC;FDGKDFWQKIAQERE;FDLNGDGEVDMEEFEQ;KNINDVDT 5 11.6 0.99296 -0.052114 7.28494 0 0 0 0 11.0415 0 6.97728 9.65145 0 0 0 7.72717 11.2739 0 A0A8I3MUD2 A0A8I3MUD2_CANLF N-acetylneuraminate lyase (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) NPL Canis lupus familiaris (Dog) (Canis familiaris) N-acetylneuraminate catabolic process [GO:0019262] cytoplasm [GO:0005737] N-acetylneuraminate lyase activity [GO:0008747] DQNRQRQFAFLFGVDEFCIQRFI;QHAAEIGADGI 2 14.2 0.94471 0.081767 0 8.54059 0 0 7.79533 0 0 0 0 0 0 0 0 8.24992 0 A0A8I3MUE3 A0A8I3MUE3_CANLF Importin subunit alpha KPNA5 Canis lupus familiaris (Dog) (Canis familiaris) NLS-bearing protein import into nucleus [GO:0006607] cytosol [GO:0005829]; nucleoplasm [GO:0005654] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] EEAYGLDKIEFLQSHENQEIY;EILPPLLELLTNSNRLTT;GIGINPYCALIE;LSKEPNPPID;TVSNITAGNRAQ 5 13.4 1.003 -0.84995 0 0 0 0 0 0 0 0 0 0 0 0 8.34501 0 0 A0A8I3MUE4 A0A8I3MUE4_CANLF Endosome-lysosome associated apoptosis and autophagy regulator family member 2 ELAPOR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ECTERPPCT;GGGGGGGG;GTKEKQAYTHIIFK;KNATFTFTWAFQRTNQGQ;TECDSSGS;YSKLVMTTNSKE 6 6.9 1.0028 -1.744 0 0 0 0 0 4.41508 0 10.1777 7.19633 6.26044 0 0 0 0 0 A0A8I3MUF4 A0A8I3MUF4_CANLF Transcription factor AP-2 delta TFAP2D Canis lupus familiaris (Dog) (Canis familiaris) inferior colliculus development [GO:0061379]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell population proliferation [GO:0042127]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LPAGRRKAANV;TYSTTGTEFASP 2 5.1 0.949 0.05044 0 0 0 0 0 0 0 0 0 0 8.64216 0 0 0 0 A0A8I3MUF8 A0A8I3MUF8_CANLF "Keratin, type I cytoskeletal 27 (Cytokeratin-27) (Keratin-27) (Type I inner root sheath-specific keratin-K25irs3)" KRT27 Canis lupus familiaris (Dog) (Canis familiaris) hair follicle morphogenesis [GO:0031069] cytoplasm [GO:0005737]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] AFGGSSSAGGYGGGSASCAAFTGNE 1 5.6 0.9794 0.035538 0 0 0 0 0 7.63023 0 0 0 0 0 0 0 0 0 A0A8I3MUG4 A0A8I3MUG4_CANLF Uncharacterized protein ZFP37 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVGRRGSAGTAEGAGRPAEMAA;MRTHTGESP;QKSHLVVHQR;VLSHKQGLIDHQ;WEQLDPAQRSL 5 9.9 1.0023 -1.013 0 0 0 0 0 0 0 0 0 0 7.66306 0 8.78839 13.2207 11.971 A0A8I3MUH2 A0A8I3MUH2_CANLF Uncharacterized protein FAM240B Canis lupus familiaris (Dog) (Canis familiaris) DKKKQAST;EVFCCETCHE 2 23.1 1.0031 -1.7158 0 0 0 0 0 0 0 0 0 7.07585 9.36087 0 0 0 0 A0A8I3MUJ9 A0A8I3MUJ9_CANLF Thioredoxin like 4A TXNL4A Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] FFRYVLLKSSF 1 10.8 0.98715 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.40586 A0A8I3MUK3 A0A8I3MUK3_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SQLVVHQRTHTGE;WKSKLTLHQR 2 4.8 0.99964 -0.61146 0 0 0 3.23086 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MUK6 A0A8I3MUK6_CANLF Uncharacterized protein PRR16 Canis lupus familiaris (Dog) (Canis familiaris) KVKEQIKIIVEDL 1 4.3 0.94017 0.059561 0 4.80627 0 0 0 0 0 0 0 0 4.83956 0 0 0 0 A0A8I3MUK7 A0A8I3MUK7_CANLF Paternally expressed 3 PEG3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AKSNNHKD;EEEGEDQEIQVE;EQKGYARKRPFECSEMRK;ESFVHSSFLF;ESFVHSSFLFEHQKIHE;GVQLAEDDGHSHMTQ;KSNNHKDSVI;QLYECPACGESF;QVEEPYYDCRECGETFTSNSAYG;TALAEHRK;VIQERGYEG;VISEFVEHQIM;VYELDSDLTKEP 13 8.7 0.99747 -3.8402 9.53321 0 0 0 0 0 11.7377 9.37008 0 7.93351 9.80292 0 0 9.73811 0 A0A8I3MUL7 A0A8I3MUL7_CANLF Vasoactive intestinal peptide VIP Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of protein catabolic process [GO:0045732]; regulation of protein localization [GO:0032880] extracellular region [GO:0005576] neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428] LAENDTPYY;LAENDTPYYDVSRN;VGNNISED 3 12.9 1.0038 -0.82506 0 0 0 0 0 0 9.57994 0 9.58988 0 0 0 9.54326 0 0 A0A8I3MUM1 A0A8I3MUM1_CANLF F-box protein 5 FBXO5 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA damage response [GO:0006974]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050] cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654] anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948] QKSAAQTYPKK 1 2.5 0.98907 -0.2606 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9587 0 A0A8I3MUM5 A0A8I3MUM5_CANLF Zinc finger protein 382 ZNF382 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEKPFEYNKDGIALIE;LCRKSIFI;PQGSVSFKDVTVDFTQE 3 7.4 1.0044 -1.0937 0 0 0 0 0 10.3223 12.5484 0 0 0 7.33628 0 9.1915 0 0 A0A8I3MUN2 A0A8I3MUN2_CANLF Uncharacterized protein LOC476453 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; oxygen binding [GO:0019825]" ALLLLLLLLLLLALARR;FTALLLLLLLLLLLALAR;HNLFFGGTE;LLILLKYPEVAAKVQ;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLA;LLLLLLLLLLLALA;TALLLLLLL;TALLLLLLLLLLL 12 8.7 1.0031 -1.7049 4.33371 0 3.70797 0 0 3.36835 6.32695 0 0 7.6565 0 0 3.57058 8.46471 6.1335 A0A8I3MUN9 A0A8I3MUN9_CANLF Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) CHMP2A Canis lupus familiaris (Dog) (Canis familiaris) autophagosome maturation [GO:0097352]; endosome transport via multivesicular body sorting pathway [GO:0032509]; exit from mitosis [GO:0010458]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of centriole elongation [GO:1903723]; nuclear membrane reassembly [GO:0031468]; plasma membrane repair [GO:0001778]; positive regulation of exosomal secretion [GO:1903543]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702] amphisome membrane [GO:1904930]; chromatin [GO:0000785]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body membrane [GO:0032585]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886] phosphatidylcholine binding [GO:0031210]; protein domain specific binding [GO:0019904] AMGDEEDEEESDA;VLDELGLSLTDELSNLP 2 13.5 0.98727 -0.49828 7.54396 8.00529 0 0 0 0 11.0296 8.22699 0 0 0 0 0 0 0 A0A8I3MUP5 A0A8I3MUP5_CANLF Zinc finger CCCH-type containing 4 ZC3H4 Canis lupus familiaris (Dog) (Canis familiaris) "lncRNA catabolic process [GO:0110064]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of lncRNA transcription [GO:0140744]; nuclear RNA surveillance [GO:0071027]" cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA binding [GO:0003723] APTSPNGRPMQGGPPPPPPPPPP;DHPEDEEDFYEEEMEYGE;DYENEQYGEY;EKSHRRLKRKRKKEREKEKRRSKK;EQYGEYEGDEEEDMGKEDYDDFT;EREKEKRRSKKR;KEREKEKRRSKKRRKSKHKR;LKRKRKKEREKEKRRSKKRRKSKHK;MNDDEDFYDEDMGD;PPGRPKPGA;PPPPSTPSPPPC;PPSQNFYENF;QDRENEEGDTGNWYSSDEDEG;RLKRKRKKEREK;RLKRKRKKEREKE;SGSGPGDT;SHRRLKRKRKKEREKEKRRSKKRRK;TKAKEPPFIRKSALEQ;VGDHPEDEEDFYEEE;VGDHPEDEEDFYEEEMEYGESE 20 14.9 0.99903 -3.0489 4.87711 5.1863 7.49498 8.82896 0 6.2759 7.21189 4.83031 8.14211 3.40381 4.5958 8.69988 0 9.56363 10.6122 A0A8I3MUP7 A0A8I3MUP7_CANLF Mitogen-activated protein kinase kinase kinase 14 MAP3K14 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ALEGLEYLHSQRILHGDIKADNV;GKMARVCWKGKRRSKAQKKRKKKSS;HPWTQYFRG;RALYYLGQ;SFAWSWRVKHGQLE;SIDSLSLSDDSEKNPSKA;YLGQALEGLEYLHSQ 7 10.7 0.99129 -0.53964 9.62178 0 0 0 0 0 0 7.44526 0 0 0 0 10.7144 8.58237 7.89579 A0A8I3MUQ0 A0A8I3MUQ0_CANLF Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (Glutamate decarboxylase 65 kDa isoform) GAD2 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cell projection [GO:0042995]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; presynaptic membrane [GO:0042734] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] AALGIGTDSVILI;DFHYPNELLQ 2 3.9 0.99272 -0.55187 0 6.58236 0 0 0 0 0 0 0 0 0 0 7.8896 0 0 A0A8I3MUQ4 A0A8I3MUQ4_CANLF Cyclin dependent kinase like 1 CDKL1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LVNLLEVFRRKRKLHL;YVATRWYRS 2 9 0.96016 0.049233 0 0 0 0 5.12031 0 0 0 0 0 0 0 0 0 0 A0A8I3MUQ5 A0A8I3MUQ5_CANLF Proteasome activator subunit 3 PSME3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537] endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039] KWILKKIKYLQ 1 4.2 0.97864 0.035491 0 0 0 2.65278 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MUR3 A0A8I3MUR3_CANLF Hepatocyte growth factor receptor (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (Tyrosine-protein kinase Met) MET Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; semaphorin receptor activity [GO:0017154]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] ADIQSEVHCMYS;FTTALQRVD;IVLLLLGLFLWLKRKKQIKDQ;LLQGRRLLQPEYCPDPL;SAIFSTFIGEHYVHVN;SEMNVNMKYQ;TSEGRFMQ;VDLFMGQFNQVLLTSI;YFLTVQRE;YSSQADEEPSQCPDCV 10 9.4 1.0032 -1.9261 11.0988 0 10.6312 0 0 0 0 12.5874 8.32908 0 9.95625 10.1398 0 0 0 A0A8I3MUT4 A0A8I3MUT4_CANLF Uncharacterized protein LOC606831 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; nucleolus [GO:0005730] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EAKGAADRAE;KKISKNPTFKLLKDKVKLLK;NELAIKKLRKKVL;YEGKTHKG 4 13.4 0.93062 0.10777 0 0 6.00982 0 0 0 0 0 0 0 0 0 0 0 5.93348 A0A8I3MUT9 A0A8I3MUT9_CANLF Serpin family A member 9 SERPINA9 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] FNRSFLLL 1 1.9 0.99013 -0.26215 0 0 0 0 0 0 0 0 10.6994 0 0 0 0 0 0 A0A8I3MUU0 A0A8I3MUU0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ERPAAFVDEQATHQSSQSL;TSHLFHQETQVFNQP;VGTSHLFHQ 3 11.3 0.9865 -0.4199 0 0 0 8.9095 0 0 13.8205 0 9.22258 0 0 0 0 0 0 A0A8I3MUW7 A0A8I3MUW7_CANLF Twisted gastrulation BMP signaling modulator 1 TWSG1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] CCDCVGMC;CIGPECID;DDDWKKLQEG;GTLWDECCDC;TVVYFDDC 5 17.5 0.99779 -3.3494 0 0 0 0 0 0 5.05702 0 0 0 0 7.14507 0 0 0 A0A8I3MUW8 A0A8I3MUW8_CANLF KIF-binding protein (KIF1-binding protein) KIFBP Canis lupus familiaris (Dog) (Canis familiaris) in utero embryonic development [GO:0001701]; mitochondrial transport [GO:0006839] cytoskeleton [GO:0005856]; mitochondrion [GO:0005739] kinesin binding [GO:0019894] EDEDERPQAEDCL;ELDLDKQSELR;EVLEAEGP;HYCHSTLKRQLEHN;RPQAEDCLGAGDHALAL 5 8.9 0.98767 -0.40133 6.99729 0 0 0 0 0 0 0 7.03221 8.73037 0 8.61537 8.8173 0 6.58609 A0A8I3MUX7 A0A8I3MUX7_CANLF Host cell factor C1 regulator 1 HCFC1R1 Canis lupus familiaris (Dog) (Canis familiaris) GTPRAQDVREPLRKQFLSE 1 16 0.95165 0.049531 0 0 0 0 0 0 0 0 0 8.75776 0 0 0 0 0 A0A8I3MUX8 A0A8I3MUX8_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (NADH-ubiquinone oxidoreductase B9 subunit) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I [GO:0005747] NKMHRVTPTHQKKKPKL 1 21.2 0.97985 0.046227 0 0 0 0 0 0 0 0 5.79699 0 0 0 0 0 0 A0A8I3MUY0 A0A8I3MUY0_CANLF RUN domain containing 1 RUNDC1 Canis lupus familiaris (Dog) (Canis familiaris) in utero embryonic development [GO:0001701] ALVCMALNEQRLVSWVNL;KVVAAVGP 2 4.2 1.005 -1.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.68701 A0A8I3MUY5 A0A8I3MUY5_CANLF RNA-binding protein 47 (RNA-binding motif protein 47) RBM47 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] RGYAFVTYCHKG;VRNLMIETT 2 4 0.99065 -0.14611 0 0 0 0 0 0 10.2705 0 0 10.0619 0 0 0 9.20031 0 A0A8I3MUY7 A0A8I3MUY7_CANLF Homeobox domain-containing protein LOC487079 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" KSQPVRENNQR;QGNAERLSVSSDD 2 7.7 0.98404 -0.25347 0 0 11.8259 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MUZ1 A0A8I3MUZ1_CANLF DDB1- and CUL4-associated factor 11 DCAF11 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleoplasm [GO:0005654] FMSACQDQTIRLYDCR;IAVSSDGREVL;QAEYFQDDMPES;QAEYFQDDMPESEEPP;SEEEEEEDEDVD 5 10.1 1.0023 -0.74058 0 0 9.21527 0 0 6.36417 0 0 0 0 7.86481 0 12.1397 0 0 A0A8I3MUZ2 A0A8I3MUZ2_CANLF Cadherin 18 CDH18 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEDVRENVVTYDD;VVILLAIVVLFITLRRSKKEPL 2 4.8 0.98972 -0.21385 0 0 0 11.9614 0 0 0 0 0 0 0 0 6.0091 0 0 A0A8I3MV02 A0A8I3MV02_CANLF KIAA1958 KIAA1958 Canis lupus familiaris (Dog) (Canis familiaris) DLMYGDIE;LVSWAHSHGTI 2 2.7 0.987 -0.23393 0 0 0 10.2282 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MV03 A0A8I3MV03_CANLF FXYD domain-containing ion transport regulator FXYD6 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] ion channel regulator activity [GO:0099106] FLCSMLAPTVLASA 1 16.1 0.98797 -0.26022 0 0 0 0 0 0 0 9.94426 0 0 0 0 0 0 0 A0A8I3MV11 A0A8I3MV11_CANLF V-set immunoregulatory receptor VSIR Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of immune response [GO:0050776]; zymogen activation [GO:0031638]" plasma membrane [GO:0005886] endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802] DLHLHHSG;FKVATPYSLYV;LVRMDSNNTQGIENP;VGILCLPLILLLVYK 4 15.8 1.0007 -0.63236 0 0 0 0 7.28429 0 0 11.1337 0 0 0 0 5.24161 0 0 A0A8I3MV18 A0A8I3MV18_CANLF Fibrous sheath CABYR binding protein FSCB Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein sumoylation [GO:0033234] calcium ion binding [GO:0005509] AAEEDFFT;DEVQPPLAETSPEVQ;EDLSNIKKEQAPAF;NIPQKEKVDKEQ;QLQQTWTKRKHVQDMTDKSL;QPPPAEKAPAEEVSDKVQPPPAE;SEGPPVEVQSPKVEE 7 13.6 1.0021 -1.3625 8.4422 0 6.48043 12.1374 0 11.7461 0 0 0 0 6.56024 0 0 0 0 A0A8I3MV26 A0A8I3MV26_CANLF "Protocadherin gamma subfamily C, 5" PCDHGC5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EVVYSFRNME;PELVLEGSLDRERE;VIVLLALRLRRWHASRLL;VLMVNATDPD;YEQFRDLQLWVT 5 6.8 1.0025 -1.3584 0 0 0 0 0 0 0 0 10.5906 0 0 8.62659 0 0 0 A0A8I3MV27 A0A8I3MV27_CANLF Phosphodiesterase (EC 3.1.4.-) PDE10A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cGMP-mediated signaling [GO:0010754]; signal transduction [GO:0007165] cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; metal ion binding [GO:0046872] AGGPGALSACGGGGGGG;GFALAAASP;GGGGGGGG;SPRGGGGGG;VDLYTGYTTRNI;VLNIPDAYADPRFN 6 6 1.0013 -0.94916 0 0 0 11.0887 0 0 0 0 9.10447 0 0 0 0 10.1994 0 A0A8I3MV34 A0A8I3MV34_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] YHYTSLYIS 1 2.5 1.0033 -0.80421 8.70729 8.65539 0 0 0 0 9.42564 0 9.08924 0 0 0 0 0 0 A0A8I3MV39 A0A8I3MV39_CANLF C-C motif chemokine CCL17 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] GRECCLEYFKGA;LHRCSWTPLL;TQTLPNTHRCKHRE 3 18.5 0.98572 -0.43471 10.5082 0 0 0 0 0 6.22713 0 0 0 0 0 0 0 0 A0A8I3MV49 A0A8I3MV49_CANLF Peroxisomal leader peptide-processing protease (EC 3.4.21.-) TYSND1 Canis lupus familiaris (Dog) (Canis familiaris) protein processing [GO:0016485] peroxisome [GO:0005777] serine-type endopeptidase activity [GO:0004252] EGGGVFAA;GGEAAEQWRFASAAPDDQ;GPAAASPAGGA;LPGTEGGGV;LVAAPLCWKARE 5 13.2 1.002 -1.2216 0 0 7.99056 0 0 0 9.90518 9.72726 11.7475 0 7.25984 8.52293 0 0 0 A0A8I3MV52 A0A8I3MV52_CANLF Teneurin transmembrane protein 4 TENM4 Canis lupus familiaris (Dog) (Canis familiaris) cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] DNDGDGLMDCMDPDCC;DSKDNDGDGLMDCMDPDCCLQ;EEFVPNSFL;ETGAPLHCSSASSTPI;GAPSGCDCKNDANCDC;GCDCKNDANCDCF;IDQELYLFDTSGKHLYT;KYYLTTDPMSGAV;LSDSANNIHF;MDCMDPDCCLQPL;NGVNVTYSPGGHIAGVQRGIMS;NWHLQPMEGQMYEITED;NWLLNSNIPLETRNLG;PHLLAGTVN;PSPPANESQRRLL;SHETGFIQYLD;SSGDEFYI;TTDIISVANEDGRR;VAGAPSGCDCKNDANCDCFS;VIQDFTEDGH;VVPPSSHETGFIQYLDS 21 8.2 0.99913 -3.1835 5.00153 11.5589 5.54021 0 10.1575 5.94703 11.9726 11.8552 9.83608 9.53204 0 7.87246 0 0 9.90341 A0A8I3MV53 A0A8I3MV53_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VGVGVGGRGQETELGSTLDSVE 1 6.5 0.98611 -0.23533 0 0 0 0 0 0 0 9.90552 0 0 0 0 0 0 0 A0A8I3MV55 A0A8I3MV55_CANLF FXYD domain-containing ion transport regulator FXYD2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; regulation of monoatomic ion transport [GO:0043269] membrane [GO:0016020] ion channel regulator activity [GO:0099106] VGLIIILSKRLR;VGLIIILSKRLRCGGKKKH 2 29.7 0.93661 0.09985 0 4.2228 0 0 0 0 4.78319 0 0 0 0 0 0 0 0 A0A8I3MV65 A0A8I3MV65_CANLF Heterogeneous nuclear ribonucleoprotein M HNRNPM Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] IERMGSGVERMGPAIERMG;KMGGMEGPFGGGMENMGR;LVMDRMGSVERMGSG;PPSILNNPNIPNEII 4 9.2 0.98808 -0.22696 9.67342 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MV76 A0A8I3MV76_CANLF Uncharacterized protein UPK3BL2 Canis lupus familiaris (Dog) (Canis familiaris) GPQSTGTVVIIAILSVLL;LEHISYVPQLSN;TVVIIAILSVLLAVLLTALL;TVVIIAILSVLLAVLLTALLALLI;VGNDTSCSPTKRGCNHPLPGPGP;VVIIAILSVLLAVLLTALLAL;VVIIAILSVLLAVLLTALLALLI 7 25.7 0.98729 -0.37061 8.59365 9.06256 0 0 0 6.66959 5.08027 0 8.35063 0 0 0 0 8.48639 0 A0A8I3MV82 A0A8I3MV82_CANLF Solute carrier family 66 member 1 SLC66A1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular amino acid homeostasis [GO:0080144]; lysine transport [GO:0015819] lysosomal membrane [GO:0005765] L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189] GVACGTPL;VGSLGVLL 2 5.5 1.0032 -2.2088 8.26716 0 4.16792 0 8.53531 0 0 0 0 0 0 0 0 0 0 A0A8I3MV85 A0A8I3MV85_CANLF Cellular repressor of E1A stimulated genes 1 CREG1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] TMSLAQTNFCRKKGFDPQSPL 1 9.5 0.97576 0.047759 0 0 0 0 0 0 0 0 0 0 0 0 7.91779 0 0 A0A8I3MV87 A0A8I3MV87_CANLF Ankyrin repeat domain 34B ANKRD34B Canis lupus familiaris (Dog) (Canis familiaris) IVQKRNSGANHYS;MVKYLLEN;TLFGLKGLEPSGKSDDTQ 3 7.6 1.0036 -1.6495 0 0 0 0 0 12.145 0 0 0 0 6.5912 0 0 0 0 A0A8I3MV88 A0A8I3MV88_CANLF SOSS complex subunit C (SOSS-C) (SSB-interacting protein 1) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (Single-stranded DNA-binding protein-interacting protein 1) INIP Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; response to ionizing radiation [GO:0010212] nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876] SRPSLNKDFRDHAEQQHI 1 17.3 0.97801 0.048313 0 0 0 0 0 0 0 4.97471 0 0 0 0 0 0 0 A0A8I3MV89 A0A8I3MV89_CANLF Signal recognition particle 19 kDa protein SRP19 Canis lupus familiaris (Dog) (Canis familiaris) "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]" "signal recognition particle, endoplasmic reticulum targeting [GO:0005786]" 7S RNA binding [GO:0008312] KLKTRTQKTGG 1 9.2 0.98437 -0.25342 0 0 0 0 0 0 0 0 0 0 11.5479 0 0 0 0 A0A8I3MV91 A0A8I3MV91_CANLF Kelch-like protein 36 KLHL36 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] SIYSLKRLDAFID 1 2.4 0.93952 0.059836 0 0 0 0 0 0 0 0 0 9.12668 0 0 0 0 0 A0A8I3MVA4 A0A8I3MVA4_CANLF Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) MAP2K2 Canis lupus familiaris (Dog) (Canis familiaris) ERK1 and ERK2 cascade [GO:0070371]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; PDZ domain binding [GO:0030165]; protein serine/threonine kinase activator activity [GO:0043539]; scaffold protein binding [GO:0097110] ARANLVDLQKKL;NLVDLQKKLAEL 2 4.1 0.95205 0.05044 0 0 7.00921 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVD3 A0A8I3MVD3_CANLF Uncharacterized protein H2BL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] PTKLAKYAVAFG 1 10.1 0.99066 -0.26842 0 0 0 0 0 0 0 14.4024 0 0 0 0 0 0 0 A0A8I3MVD5 A0A8I3MVD5_CANLF NECAP endocytosis associated 2 NECAP2 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] clathrin vesicle coat [GO:0030125] ALCSGPGG;PPPGGKTSTLIPP;RFQQILCYPHRRWKWWVKQQCE;YPHRRWKWWVKQQCEFAKQAQNPD 4 25.4 0.58447 0.37119 10.8929 0 10.2881 0 9.74995 0 0 11.432 0 0 0 10.0575 10.6778 10.6733 10.5411 A0A8I3MVD6 A0A8I3MVD6_CANLF TNFAIP3 interacting protein 1 TNIP1 Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein biosynthetic process [GO:0009101]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of protein deubiquitination [GO:1903003] cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019] AGVPAPPA;IQSQPIPSPSTFAVGELLEES;LSVCAEEPDRSQLFMHLGRMALEFN;PHHGFEDWSQ;QDQLSPLTRQREYQEKEIQ;QRTELLEVNKQWDQHFRSMKQQ;VEPHPEHLC;VGKKGVAG;YHVEPHPEHLC 9 18.7 1.0033 -2.102 0 0 8.09814 0 10.3194 0 13.0057 13.0505 13.5136 7.79948 0 0 0 0 0 A0A8I3MVE0 A0A8I3MVE0_CANLF AP-1 complex subunit gamma AP1G2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-1 adaptor complex [GO:0030121] AAILEKMP;EKVLQSHMSL 2 2.3 1.0031 -1.7158 0 0 0 0 0 0 10.7134 0 0 0 0 0 0 6.76673 0 A0A8I3MVE3 A0A8I3MVE3_CANLF Transmembrane p24 trafficking protein 7 TMED7 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] LLLLLLLP;LLLLPGPG;NRVSALTQMESACV;RLLALLLLLLLPG 4 12.8 1.0029 -0.98397 0 4.74712 0 0 0 0 0 0 0 0 3.07396 11.3949 0 0 0 A0A8I3MVE9 A0A8I3MVE9_CANLF Olfactory receptor OR10AG1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIVVVLFYGTATITYLQPKPN;QTCQIFSLPFCG;TLRNKDIMVALRKLLTKL;VGKLISLFYTILIPTLNP 4 22.9 0.99229 -0.032353 8.60907 5.00993 0 0 0 6.8296 0 0 0 0 0 0 0 0 0 A0A8I3MVF0 A0A8I3MVF0_CANLF Acetylcholine receptor subunit epsilon CHRNE Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] DTEAYTENGE;FRWDKLLRGGGQGRGWGAVGR;KIDIDTEAYTENGEWA 3 5.5 0.96509 0.048716 0 0 0 0 0 0 0 0 0 0 0 9.25423 0 11.1504 0 A0A8I3MVF1 A0A8I3MVF1_CANLF Amyloid beta precursor like protein 2 APLP2 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] heparin binding [GO:0008201]; transition metal ion binding [GO:0046914] ADLEDFTEAAVDEDDEDEEEGEEVV;ATGKLLVLLLLGLTAP;AVDEDDEDEEEGEEVVEDRDYYYD;EAEPESVG;EDDEDEEEGEEVV;EDEDEEEE;EDEDEEEEEDEEEDYDIYK;EDEEEEEDEEEDYD;EEEDEDEEEEEDEEEDYDIYKSE;EEGEEVVEDRD;GLEAEPESVGPL;LVGEFVSDVLLVPEKCQFS;YVAQEIQEEIDELLQ 13 16.7 0.98469 -0.25484 0 9.29221 10.0224 5.44834 3.53094 10.8064 8.51538 0 7.09413 11.7849 3.49147 0 5.67573 9.45494 0 A0A8I3MVF3 A0A8I3MVF3_CANLF Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) HK1 Canis lupus familiaris (Dog) (Canis familiaris) canonical glycolysis [GO:0061621]; establishment of protein localization to mitochondrion [GO:0072655]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731] cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; glucokinase activity [GO:0004340]; peptidoglycan binding [GO:0042834] LVKMAKESLLFEG;MMTCGYDDQQ;PGPWGWSRGRRRRRRS;TGARSRGAREPP;YMEEMKNVEMLEG 5 6.4 1.0012 -0.93627 0 0 0 5.32434 14.5215 0 0 8.89779 0 7.65399 0 0 9.32654 0 15.0875 A0A8I3MVF9 A0A8I3MVF9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SYFTRTPLVFC 1 12.4 0.98111 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.48438 A0A8I3MVG4 A0A8I3MVG4_CANLF Glia maturation factor gamma GMFG Canis lupus familiaris (Dog) (Canis familiaris) actin filament debranching [GO:0071846]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316] actin cortical patch [GO:0030479] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933] KTELPERQPRFVVYSYK;VFEIRTTEDLTEAWLQE 2 36.6 0.9899 -0.22217 0 0 0 0 7.77959 0 0 0 0 0 7.45508 0 0 0 0 A0A8I3MVG6 A0A8I3MVG6_CANLF Olfactory receptor OR10AG68 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QGFLFGIFFL;VNLWTQDRSI 2 6.2 0.99927 -0.61146 0 0 0 0 0 0 0 8.14062 0 0 0 0 0 0 0 A0A8I3MVG7 A0A8I3MVG7_CANLF Denticleless E3 ubiquitin protein ligase homolog DTL Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] DEAAYIWKVS;PKPPSSFKMSIR;RDGNIMVWDTRCNKKDGF 3 5.8 0.98915 -0.19804 9.87922 0 0 0 0 0 0 0 0 0 0 0 0 6.49333 0 A0A8I3MVJ3 A0A8I3MVJ3_CANLF Ribosome maturation protein SBDS LOC119864225 Canis lupus familiaris (Dog) (Canis familiaris) cytosolic ribosome assembly [GO:0042256] ISAFGTDD;KKLKEKLKPLIKVIE;QQLEIVCLIDPGCFRE 3 15.6 0.98698 -0.40883 5.20758 0 0 0 0 0 0 0 0 4.90915 0 0 0 0 0 A0A8I3MVJ7 A0A8I3MVJ7_CANLF Prokineticin 2 PROK2 Canis lupus familiaris (Dog) (Canis familiaris) endothelial cell proliferation [GO:0001935] extracellular region [GO:0005576] CGGGMCCA;LLLLLLLP;TSFNRFICL 3 23.1 1.0023 -1.37 0 0 0 0 0 4.79317 0 7.46557 0 0 0 0 0 0 0 A0A8I3MVK0 A0A8I3MVK0_CANLF Uncharacterized protein GPR31 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GVDLSFSIVWQEALFFLQFI;GVGIAFLTAVAL 2 10.1 0.93216 0.098646 0 9.1373 6.82693 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVK6 A0A8I3MVK6_CANLF "Zinc finger protein, FOG family member 1" ZFPM1 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] EAAGAATPEAEAEAEG;PAGTPGAPGTAAPAPAP;PSPGLDRKALTEA 3 4.7 0.98952 -0.19657 0 0 0 7.06609 0 13.3008 0 0 0 0 10.0235 0 14.7073 0 0 A0A8I3MVL1 A0A8I3MVL1_CANLF Olfactory receptor OR5M10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] FIIVLSYLFIIVAILRI;VIHAMQQIIQGN;VIHAMQQIIQGNI;VLIGTNSHLQTPMY 4 14 0.99532 -0.5648 0 0 0 10.5337 0 11.0961 11.0419 0 0 0 0 0 0 6.854 0 A0A8I3MVL5 A0A8I3MVL5_CANLF Homeobox protein cut-like CUX1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" DLSGSARRKGKDQ;FGHYVLGLSQGSVSE;GVWKDHWWSTV;IFSTGPYS;NVGSMFQYWKRFDLQQLQRELDA;PPPPPPPEGPAD;PWNKLTVRGKEPF;SLKKPPTA;SSEGDSCDGVEAAEGPGAAD;YMYQEVDTIELT 10 8.7 1.0019 -0.74434 8.68275 5.42173 0 0 0 7.98128 14.277 0 0 8.52203 9.81493 6.53274 0 0 0 A0A8I3MVN5 A0A8I3MVN5_CANLF LY6/PLAUR domain containing 1 LYPD1 Canis lupus familiaris (Dog) (Canis familiaris) side of membrane [GO:0098552] GGKPSRVRWGTAPGVSGCCGTPAA;GWGPGGSPIPEGS 2 15.8 0.98159 -0.24877 0 0 0 0 0 0 9.22747 0 0 0 0 0 0 0 0 A0A8I3MVP1 A0A8I3MVP1_CANLF Histone deacetylase 1 (HD1) (EC 3.5.1.98) HDAC1 Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; heterochromatin [GO:0000792]; neuronal cell body [GO:0043025]; NuRD complex [GO:0016581]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] E-box binding [GO:0070888]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; Krueppel-associated box domain binding [GO:0035851]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] LPMLMLGG;MEIYRPHK 2 3.3 1.004 -1.1044 0 0 0 0 0 0 6.94825 0 6.20783 7.4793 0 0 0 0 0 A0A8I3MVP9 A0A8I3MVP9_CANLF Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) PPA1 Canis lupus familiaris (Dog) (Canis familiaris) phosphate-containing compound metabolic process [GO:0006796] cytoplasm [GO:0005737]; extracellular exosome [GO:0070062] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] VDDPDAANYNDIND 1 4.8 0.93466 0.060938 0 0 0 6.92873 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVQ1 A0A8I3MVQ1_CANLF Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) LOC119870648 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" DEFTFLELT;DTIFGRFG;DVVFDSQGKNWWHHNL;IVFPTAWMN 4 8.6 1.0029 -1.5245 0 9.39283 9.83539 0 0 0 0 0 0 0 0 0 0 0 7.56476 A0A8I3MVQ7 A0A8I3MVQ7_CANLF Exportin 6 XPO6 Canis lupus familiaris (Dog) (Canis familiaris) protein export from nucleus [GO:0006611] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] DIHLFKQN;GVDANQKNVLGRNFKMDRD;STTMDAVTPLIS;VTAATPPPS 4 4.5 1.0031 -0.88105 10.3286 0 0 0 0 0 9.94717 0 8.69335 0 11.065 0 0 0 0 A0A8I3MVQ9 A0A8I3MVQ9_CANLF 14-3-3 protein epsilon Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165] cytoplasm [GO:0005737] phosphoserine residue binding [GO:0050815] AEQAERYDEMVESMK;ENKGEDKLKMIRE;SWRIISSVEQKEENKGEDKL 3 37.7 0.8646 0.17839 8.05989 0 0 7.8282 0 5.97515 0 0 0 0 0 0 0 0 0 A0A8I3MVS5 A0A8I3MVS5_CANLF Glial cell derived neurotrophic factor GDNF Canis lupus familiaris (Dog) (Canis familiaris) branching involved in ureteric bud morphogenesis [GO:0001658]; commissural neuron axon guidance [GO:0071679]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; enteric nervous system development [GO:0048484]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mRNA stabilization [GO:0048255]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron apoptotic process [GO:0043524]; neural crest cell migration [GO:0001755]; organ induction [GO:0001759]; peristalsis [GO:0030432]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; postganglionic parasympathetic fiber development [GO:0021784]; postsynaptic membrane organization [GO:0001941]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of semaphorin-plexin signaling pathway [GO:2001260]; sympathetic nervous system development [GO:0048485]; ureteric bud formation [GO:0060676] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] glial cell-derived neurotrophic factor receptor binding [GO:0030116]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971] QAAAAGPEHSRG 1 5.7 0.9527 0.05044 0 0 0 0 0 8.98851 0 0 0 0 0 0 0 0 0 A0A8I3MVS8 A0A8I3MVS8_CANLF UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (N-acetylglucosamine-1-phosphate transferase) DPAGT1 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757]; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0003975]; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity [GO:0003976] FIAAHLCGQ 1 2.2 1.0042 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 9.47865 0 A0A8I3MVT0 A0A8I3MVT0_CANLF Heterogeneous nuclear ribonucleoprotein L HNRNPL Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770] mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; transcription cis-regulatory region binding [GO:0000976] AAGGGGGG;GGGGGGGA;GGGGGGGG;HYHDEGYGPPPPHY;PAIMPGQSYGL;QMKNPNGPYPYTLKLC;YHSHYHDEGYGPPPP;YHSHYHDEGYGPPPPHYEG 8 10.9 0.98664 -0.32837 10.7186 0 10.3705 0 0 10.6904 14.7211 9.66229 14.6948 0 0 12.0202 10.3098 13.2907 10.3472 A0A8I3MVU2 A0A8I3MVU2_CANLF IQ motif containing E IQCE Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HGSGGAAG;VGASWLMCLWFLFLALT 2 2.5 0.98096 0.046227 0 0 0 0 0 0 0 0 10.931 0 0 0 0 0 0 A0A8I3MVV3 A0A8I3MVV3_CANLF F-box protein 17 FBXO17 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005] HDRMSLTITTNNHQA 1 4.5 0.94973 0.053889 0 10.0298 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVV7 A0A8I3MVV7_CANLF Solute carrier family 28 member 3 SLC28A3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] nucleoside transmembrane transporter activity [GO:0005337] GFMAFDWLGQQVQTFLEN;MVIAACVLNFQ;WRPVFWGIGLQFL 3 8.2 0.98675 -0.33122 10.4632 11.8163 8.94772 0 0 0 0 10.509 9.48388 0 0 0 12.0489 0 0 A0A8I3MVW3 A0A8I3MVW3_CANLF poly(A)-specific ribonuclease (EC 3.1.13.4) CNOT8 Canis lupus familiaris (Dog) (Canis familiaris) CCR4-NOT core complex [GO:0030015]; P-body [GO:0000932] nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] HILNLFFPSIYDVKYLMKSC 1 8.4 0.95074 0.053689 0 0 9.40967 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVX1 A0A8I3MVX1_CANLF SAP domain containing ribonucleoprotein SARNP Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; transcription export complex [GO:0000346] chromatin binding [GO:0003682] RFGLNVSSISRK;SEIPQTERMQKRAE;TEVKKYMYIYMY 3 17.9 0.99353 -0.15954 14.5286 10.3138 0 0 0 8.18567 0 0 0 0 0 0 0 0 0 A0A8I3MVX5 A0A8I3MVX5_CANLF Sister chromatid cohesion protein DCC1 DSCC1 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of mitotic sister chromatid cohesion [GO:0034088] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; Ctf18 RFC-like complex [GO:0031390]" EIFDFSNNYWELRRCRPKLKKLKKL;LLDQIQASEEEIMTQ;PKLKKLKKLL 3 10.5 0.99075 -0.51131 0 7.8748 0 0 0 0 0 0 0 0 7.47127 0 0 0 7.24755 A0A8I3MVX8 A0A8I3MVX8_CANLF Decaprenyl diphosphate synthase subunit 1 PDSS1 Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] heterotetrameric polyprenyl diphosphate synthase complex [GO:0032478] all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; protein heterodimerization activity [GO:0046982] EDLVRGEFLQ;VIEDLVRGEFLQLGSKEN 2 4.4 0.98757 -0.46224 0 10.4015 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MVY0 A0A8I3MVY0_CANLF Zinc finger protein 229 ZNF229 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LHVHQRVHTGEKPY;LSYWKIWEQVAGELTGSQDHRVNL 2 6.4 0.97348 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1808 A0A8I3MVY1 A0A8I3MVY1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AELLRSSCIYLETRKS;FIHTGEKPYECSECGKAFSHNSSL 2 7.2 0.99005 -0.51626 9.15122 0 0 0 8.69401 0 0 0 0 0 0 0 0 0 0 A0A8I3MVY4 A0A8I3MVY4_CANLF Uncharacterized protein ODF4 Canis lupus familiaris (Dog) (Canis familiaris) GPDRNGQACGEHCSEP 1 6.4 0.9554 0.049233 0 0 0 0 0 0 6.32285 0 0 0 0 0 0 0 0 A0A8I3MVZ5 A0A8I3MVZ5_CANLF NFKB inhibitor beta NFKBIB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; regulation of canonical NF-kappaB signal transduction [GO:0043122] DRTSDTDHPPV;DSDSGDEGDEYDDIV;EASAVEKLYAAGAGLHI;QTALHLAAILGEAS 4 15.1 1.0048 -1.0505 12.5525 12.5002 0 11.559 0 0 0 0 0 11.7614 11.8487 0 0 0 0 A0A8I3MW09 A0A8I3MW09_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC100683471 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] L-arginine transmembrane transporter activity [GO:0061459] FMAFLFELSD;LTGLLVLGASESAL;LVDLMSIGTLLAYS 3 6.2 0.98385 -0.25266 0 3.5451 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MW18 A0A8I3MW18_CANLF Pleckstrin homology and RUN domain containing M2 PLEKHM2 Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764] DLPHKPIQE;EVIRVTKKKKTGKKK;LFKMIRMSTGHMEGNLQLL;LVSGLEFIRFDLDLDAPYLD;RVTKKKKTGKKKKARSD;SPCIPCCLVITDD;VLCHCSPPEGTIT 7 9.5 0.97698 0.046227 0 0 0 0 0 0 0 0 0 0 3.92666 0 0 0 0 A0A8I3MW22 A0A8I3MW22_CANLF Olfactory receptor OR4C11I Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EGKKKALSTCTSHIIVVILFFGPC;ILYVGTVVGNLLIIVTIK 2 13.5 0.966 0.048313 4.55471 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MW30 A0A8I3MW30_CANLF Transmembrane protein 199 TMEM199 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; lysosomal lumen acidification [GO:0007042]; lysosomal protein catabolic process [GO:1905146]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471] oxysterol binding [GO:0008142] GTLSDLGKQVRSVKAL 1 7.7 0.99163 -0.041421 0 0 0 0 0 0 9.07791 0 0 0 0 0 0 0 0 A0A8I3MW32 A0A8I3MW32_CANLF Transmembrane protein 234 TMEM234 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SSVSKTQG 1 5.7 0.98937 -0.21478 0 0 9.89936 6.59228 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MW45 A0A8I3MW45_CANLF G-protein coupled receptor 4 GPR4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis involved in wound healing [GO:0060055]; glomerular mesangial cell development [GO:0072144]; negative regulation of angiogenesis [GO:0016525]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of inflammatory response [GO:0050729]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell adhesion [GO:0030155]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FIFYTNIYISIAFLCCISVDRYLA;TLPLWVDYFLHHD 2 10.2 0.93198 0.10567 0 0 10.2246 0 0 3.80797 0 0 0 0 0 0 0 0 0 A0A8I3MW57 A0A8I3MW57_CANLF Transmembrane protein 156 TMEM156 Canis lupus familiaris (Dog) (Canis familiaris) NFTRICQGI;YVLVLVVIIFFLILTIHKILE 2 9.6 1.0023 -0.75705 0 0 0 7.07682 0 0 9.30506 0 0 0 0 0 0 0 0 A0A8I3MW59 A0A8I3MW59_CANLF Tetratricopeptide repeat domain 9 TTC9 Canis lupus familiaris (Dog) (Canis familiaris) bone development [GO:0060348] PGGGGGVPA;PMCAPGGGGGV 2 6 1.0011 -0.93428 0 0 0 0 0 8.81275 0 11.1344 0 0 0 0 0 0 0 A0A8I3MW63 A0A8I3MW63_CANLF U6 snRNA-associated Sm-like protein LSm3 LSM3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] RNA binding [GO:0003723] SLDERIYVKMRNDLE 1 14.7 0.95636 0.053874 0 0 0 0 0 0 0 0 0 0 0 10.3992 0 0 0 A0A8I3MW64 A0A8I3MW64_CANLF Organic anion transporter 3 (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8) SLC22A8 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; response to toxic substance [GO:0009636] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] transmembrane transporter activity [GO:0022857] EDIETWSWQTN;VLTCSYLLLAASGSSA 2 4.4 0.99402 -0.12203 0 0 0 10.8983 0 0 0 0 0 9.30067 0 0 0 0 0 A0A8I3MW65 A0A8I3MW65_CANLF Eukaryotic translation initiation factor 4E family member 3 EIF4E3 Canis lupus familiaris (Dog) (Canis familiaris) eukaryotic translation initiation factor 4F complex [GO:0016281] RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743] GSAPRRARRRRRRRRR;LAWISSYSPSSPA;PERAAWRGRRRRRRRRRRVRAG;VGSPSLPP 4 11.8 0.98642 -0.42015 0 6.82349 4.10442 0 0 0 9.74121 0 7.19407 5.27322 0 0 7.3837 0 9.20026 A0A8I3MW76 A0A8I3MW76_CANLF guanylate kinase (EC 2.7.4.8) GUK1 Canis lupus familiaris (Dog) (Canis familiaris) dGDP biosynthetic process [GO:0006185]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; photoreceptor inner segment [GO:0001917] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385] AAALGRAPSDGMSGPR 1 7.3 0.98416 -0.2398 0 0 0 0 0 0 0 10.0041 0 0 0 0 0 0 0 A0A8I3MW90 A0A8I3MW90_CANLF NACC family member 2 NACC2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; protein homooligomerization [GO:0051260]; protein-containing complex localization [GO:0031503] chromatin [GO:0000785]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EAYDTMAEEQYGQ;GVKHKVLLRRLL;GVKHKVLLRRLLATFFDRNT;TDSPTSYHNEEDEED;TDSPTSYHNEEDEEDDEAYDTMAE 5 8.4 0.7303 0.25344 0 10.0776 5.53116 0 0 5.87293 9.65689 10.1054 0 0 0 3.41319 0 0 0 A0A8I3MW97 A0A8I3MW97_CANLF Protein tyrosine phosphatase 4A2 PTP4A2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] protein tyrosine phosphatase activity [GO:0004725] PPPNQIVDDW;PVEKEGIHVLDWP 2 16.2 1.0011 -0.93338 0 3.75969 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MWA1 A0A8I3MWA1_CANLF "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial" COX16 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial inner membrane [GO:0005743] IVGGSFGLREFSQ 1 12.3 0.98542 -0.25941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.0567 A0A8I3MWA9 A0A8I3MWA9_CANLF BUD13 homolog BUD13 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; RES complex [GO:0070274]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] AGVDGGPD;EDLDRMLREQEREGDPMANFIKKN;RPKPGGAG;SERDELYARWGK 4 7.2 1.003 -2.4224 13.9604 0 0 0 6.053 0 0 12.1128 0 9.49607 0 0 0 0 12.1766 A0A8I3MWB1 A0A8I3MWB1_CANLF Calpain 12 CAPN12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] DEADFTLRVFSERRHA;EVMRGGHMNEAFVDFTGGVGE;NSGGSQPG;RHAAPRPPPQVPY 4 10.1 0.98733 -0.36315 0 3.32754 0 0 7.57984 0 0 0 11.041 0 9.39735 0 0 0 0 A0A8I3MWB4 A0A8I3MWB4_CANLF Olfactory receptor OR5L1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EIITIMIILTSYLLILITILR 1 6.8 0.97381 0.047166 0 0 0 0 0 0 7.02337 0 0 0 0 0 0 0 0 A0A8I3MWB8 A0A8I3MWB8_CANLF Regulator of chromosome condensation 2 RCC2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027] "chromosome, centromeric core domain [GO:0034506]; early endosome membrane [GO:0031901]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleus [GO:0005634]; plasma membrane [GO:0005886]" microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] CSSSSGGG;GGSSGDEDGLELDGA;IEYDCELVPRRVA;KKLPEYNPRTL;LIEGLSHEVIVSA;NEKGQLGHG;VLDSQKRVFSWGFGGYGR 7 16.3 1.0031 -1.5827 12.1917 11.2542 11.6612 8.4847 0 0 11.8649 9.16096 11.1243 0 0 0 0 7.37452 0 A0A8I3MWC5 A0A8I3MWC5_CANLF Cytohesin 4 CYTH4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] centriolar satellite [GO:0034451]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] GEGKVVEG;THTFFNPDREGWLLK 2 5.8 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 5.37152 0 0 A0A8I3MWD8 A0A8I3MWD8_CANLF Ring finger protein 214 RNF214 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-protein transferase activity [GO:0004842] QEWETRLNGVRMMKKNVRDQFNNHI 1 4.9 0.97489 0.035538 0 0 0 0 0 0 0 0 7.95449 0 0 0 0 0 0 A0A8I3MWE0 A0A8I3MWE0_CANLF Mortality factor 4 like 1 MORF4L1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] ANQEQYAEGKMRG;LAYTPLDEKSLALL;TSETPPPP;VLCFHGPLLYEAK;YSGWNKNWDEWV 5 18.6 1.0041 -1.0791 0 0 0 0 0 0 9.15084 0 0 0 0 0 11.5361 0 0 A0A8I3MWE2 A0A8I3MWE2_CANLF "NPHS2 stomatin family member, podocin" NPHS2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LGACEWLLVLTSLLFII 1 5.5 0.98436 0.046227 0 0 0 4.03395 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MWE6 A0A8I3MWE6_CANLF Shieldin complex subunit 2 SHLD2 Canis lupus familiaris (Dog) (Canis familiaris) DHWVGETIL;ELETDKNKIYKQ;FVLDDNSCPLQQE;VMLTVEQVQGQHYVLVLWG 4 6.3 0.98811 -0.49568 7.26707 0 0 0 0 0 0 0 0 0 0 0 10.9233 0 0 A0A8I3MWF9 A0A8I3MWF9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RVARWVLQHTSKSKIMSW 1 16.1 0.98342 -0.25658 0 0 0 0 0 0 0 0 0 0 0 0 0 9.27456 0 A0A8I3MWG0 A0A8I3MWG0_CANLF Skin secretory protein xP2-like C3H4orf19 Canis lupus familiaris (Dog) (Canis familiaris) GEAPGAGS 1 3.3 1.0047 -1.1044 0 0 0 0 0 0 0 0 0 0 9.59515 0 0 0 0 A0A8I3MWG1 A0A8I3MWG1_CANLF Polyhomeotic homolog 2 PHC2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AQSVNSATASGIAQQ;FVIQEGAEPFP;STSRRRQGQRDLE 3 4.7 0.87995 0.13824 0 0 0 0 0 0 7.142 9.62587 0 0 0 0 0 0 0 A0A8I3MWH1 A0A8I3MWH1_CANLF Core histone macro-H2A MACROH2A2 Canis lupus familiaris (Dog) (Canis familiaris) "brain development [GO:0007420]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of keratinocyte differentiation [GO:0045618]; sex-chromosome dosage compensation [GO:0007549]" Barr body [GO:0001740]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786] chromatin DNA binding [GO:0031490]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; structural constituent of chromatin [GO:0030527] EDKKLKSVAFPP;TIASGGVL 2 5.4 0.94211 0.05044 0 0 0 4.87234 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MWH2 A0A8I3MWH2_CANLF Protein LEG1 homolog LOC612694 Canis lupus familiaris (Dog) (Canis familiaris) IAKASNISDVYPPL;PEAMKKWNEFYQHVKSHSSSFDE 2 11 0.93339 0.10731 0 0 0 0 0 4.48214 0 0 0 0 0 0 6.1887 0 0 A0A8I3MWH6 A0A8I3MWH6_CANLF Exonuclease 3'-5' domain containing 2 EXD2 Canis lupus familiaris (Dog) (Canis familiaris) 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] ELLQALREFYNTDTVTDEMLQ;PERRQVRSGARAL;VLVRLPKLI 3 11 1.002 -1.3082 0 9.31145 0 0 4.30772 0 0 11.2658 0 0 0 0 0 0 0 A0A8I3MWI6 A0A8I3MWI6_CANLF RNA-binding S4 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA binding [GO:0019843] ELRVLRRY;EQKLLKQVDFLNW;RRHVLEYNEERDDFD 3 20.8 1.0026 -1.3262 0 0 8.0954 0 0 0 0 0 8.02314 0 0 0 0 8.52623 0 A0A8I3MWJ3 A0A8I3MWJ3_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) ROS1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] CALKCNDT;DLLTYLRK;EFFSVNAS;ELKYKMLEFQER;ISVIQCTVLNSCLKSCVTN;IVTHVKLLV;LYWTTLYSVESTR;RMFVLPSGKYYKQ;SNTEEITPPSI;SRPTNHSNGKKQCFCGVTEF;THVKLLVNDMVVD;VICLNSGDITSI;VILGSYAQP 13 6.5 0.99908 -3.2258 11.3807 0 0 9.37689 0 11.5828 0 8.92819 0 0 9.64652 11.0129 10.8966 9.94341 0 A0A8I3MWK0 A0A8I3MWK0_CANLF Protein Wnt WNT3A Canis lupus familiaris (Dog) (Canis familiaris) axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; B cell proliferation [GO:0042100]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell fate commitment [GO:0060923]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; modulation of chemical synaptic transmission [GO:0050804]; myoblast differentiation [GO:0045445]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; non-canonical Wnt signaling pathway [GO:0035567]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; protein localization [GO:0008104]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of postsynapse to nucleus signaling pathway [GO:1905539]; regulation of presynapse assembly [GO:1905606]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874] cell surface [GO:0009986]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Wnt-Frizzled-LRP5/6 complex [GO:1990851] co-receptor binding [GO:0039706]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; transcription coactivator activity [GO:0003713] FADARENRPDARSA;QPDFRSIGDFLKDK 2 8 0.93643 0.060951 0 0 0 0 0 0 0 10.0676 0 0 0 0 0 0 0 A0A8I3MWK6 A0A8I3MWK6_CANLF Mannosyltransferase (EC 2.4.1.-) ALG12 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] AAGAAGGC;ALLPAGHG;ATAWVRGA 3 3.5 1.0041 -1.1044 0 0 0 0 0 0 0 6.6174 0 0 0 0 0 0 0 A0A8I3MWL3 A0A8I3MWL3_CANLF CEA cell adhesion molecule 1 CEACAM1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] DNSTLTIDP;FQNITLKDTGYYTLQ;KYQCEVSNPV;TVSEPVSQPLLTA;VIAALVYLQYFRKT;VLTCESQTQSTSCL 6 14.3 1.0031 -0.89389 0 0 0 0 0 0 0 0 12.65 0 0 0 11.8766 10.8463 0 A0A8I3MWL4 A0A8I3MWL4_CANLF sphingomyelin phosphodiesterase (EC 3.1.4.12) SMPD5 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; sphingomyelin catabolic process [GO:0006685] endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrial membrane [GO:0031966] sphingomyelin phosphodiesterase activity [GO:0004767] ALPAGLDFVCLQE 1 2.7 0.99053 -0.27395 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9167 A0A8I3MWL7 A0A8I3MWL7_CANLF "Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.-) (Heme O synthase)" COX10 Canis lupus familiaris (Dog) (Canis familiaris) aerobic respiration [GO:0009060]; heme A biosynthetic process [GO:0006784]; heme O biosynthetic process [GO:0048034]; mitochondrial fission [GO:0000266]; respiratory chain complex IV assembly [GO:0008535] cytochrome complex [GO:0070069]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nucleolus [GO:0005730] farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495] SIANTWVGAVVG 1 2.7 0.9443 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 7.61191 0 0 A0A8I3MWM2 A0A8I3MWM2_CANLF Olfactory receptor OR8J3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FYGTLLFMYLQPQT;LYMVVVSPQICLF;VGVSDRPDLQMPLFFVFLVI 3 15.2 0.99179 -0.038565 0 0 10.0135 0 5.33949 0 0 0 0 0 0 0 0 8.45381 0 A0A8I3MWM8 A0A8I3MWM8_CANLF Protein phosphatase 1 regulatory subunit 13 like PPP1R13L Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AYGSLERAPSPRPRAFD;GPGGPEPELSSISEG;LEPEPELE 3 4.8 0.99341 -0.16197 0 0 0 0 0 0 0 0 0 0 7.94953 7.74483 0 10.5928 0 A0A8I3MWN1 A0A8I3MWN1_CANLF Testis specific serine kinase 4 TSSK4 Canis lupus familiaris (Dog) (Canis familiaris) fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; spermatid development [GO:0007286] sperm flagellum [GO:0036126] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] KETQKEVTFPSNYSISQECKNLVL 1 7.1 0.99207 -0.28827 0 10.1642 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MWP4 A0A8I3MWP4_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) CDKN3 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] EPIEDEQTPIQI;IFVFCTRGELSKYRVPN 2 19.9 0.9369 0.0975 0 0 0 0 0 0 9.94272 0 0 0 0 0 0 0 0 A0A8I3MWP9 A0A8I3MWP9_CANLF Transcription factor AP-2 beta TFAP2B Canis lupus familiaris (Dog) (Canis familiaris) aorta morphogenesis [GO:0035909]; collecting duct development [GO:0072044]; distal tubule development [GO:0072017]; ductus arteriosus closure [GO:0097070]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; glucose metabolic process [GO:0006006]; hindlimb morphogenesis [GO:0035137]; metanephric nephron development [GO:0072210]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell differentiation [GO:0045595]; regulation of insulin secretion [GO:0050796]; retina layer formation [GO:0010842]; skin development [GO:0043588]; smooth muscle tissue development [GO:0048745]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALKGMDKMFLN;LPAGRRKAANV;VGEVQRRLSPPECLNA;VIKKVPVPPKSVTSLMMNK 4 12 0.98742 -0.46315 0 9.0545 8.95388 0 0 6.78594 0 0 0 0 0 0 0 0 0 A0A8I3MWQ1 A0A8I3MWQ1_CANLF AarF domain-containing protein kinase 1 ADCK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLYPLFAC;LFACMLTA;LYQVLTDEFRLD 3 5.3 1.0024 -0.71711 0 10.932 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MWQ4 A0A8I3MWQ4_CANLF Extracellular leucine rich repeat and fibronectin type III domain containing 1 ELFN1 Canis lupus familiaris (Dog) (Canis familiaris) synapse organization [GO:0050808] dendrite [GO:0030425]; excitatory synapse [GO:0060076] CELYSNPFYCSC;DLHDILDYW;GPEMEAPG;MKVKQLTQ;NQIINNCIDALKSEA;TKNEIAYIEDGAFSGQ 6 8.3 1.0019 -1.2093 9.37741 0 0 3.13922 0 0 8.96999 11.5497 0 0 0 0 3.27801 4.25671 6.38996 A0A8I3MWR1 A0A8I3MWR1_CANLF Kelch like family member 28 KLHL28 Canis lupus familiaris (Dog) (Canis familiaris) ALGGYDGQSYLQ;PAHMNSVERYDP 2 4.2 0.9914 -0.19431 0 0 0 7.90995 0 0 0 10.5009 0 0 0 0 0 0 0 A0A8I3MWR3 A0A8I3MWR3_CANLF FERM domain containing 1 FRMD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] DLDPDPGG;EYMFMDLEQ;RVLRSQCAHREEAYFLLAAYG;VGRYFEPQAYFPP 4 10.2 1.002 -1.3083 9.91174 0 0 0 0 0 0 0 0 0 0 0 0 10.254 0 A0A8I3MWX3 A0A8I3MWX3_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] QKMKHIGGAQYLH 1 8.9 0.94321 0.059681 0 0 0 0 0 0 0 0 10.1171 0 0 0 0 0 0 A0A8I3MWX5 A0A8I3MWX5_CANLF Carnosine dipeptidase 1 CNDP1 Canis lupus familiaris (Dog) (Canis familiaris) carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] DVQPARREDGWL;IPGQVIGKFSIRL 2 5.4 0.91634 0.11 0 6.80645 8.57988 0 0 0 0 0 10.7136 0 6.8857 0 0 0 0 A0A8I3MWX6 A0A8I3MWX6_CANLF Beclin 1 BECN1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; cellular response to nitrogen starvation [GO:0006995]; late endosome to vacuole transport [GO:0045324] "phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" ERLDQEEAQYQR;GVSRRFIPP 2 7.6 1.0017 -0.75377 0 0 0 0 9.41631 0 0 10.7194 0 0 0 0 8.31066 0 0 A0A8I3MWY6 A0A8I3MWY6_CANLF Membrane integral NOTCH2 associated receptor 2 MINAR2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525] endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765] cholesterol binding [GO:0015485] VGLILLLVA 1 3.7 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 3.28383 0 A0A8I3MX24 A0A8I3MX24_CANLF Syncytin-1 (Endogenous retrovirus group W member 1) (Syncytin) LOC119881605 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PLHETYPQGTRSFSEICS;VGLSDGGG 2 4.5 0.97923 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.39888 A0A8I3MX25 A0A8I3MX25_CANLF Leucine rich repeat containing 20 LRRC20 Canis lupus familiaris (Dog) (Canis familiaris) AEVRVIAPPLIK;TTLPALETINLEENNI 2 20.9 0.95243 0.05044 0 0 0 0 0 0 0 0 0 0 0 2.46313 0 0 0 A0A8I3MX26 A0A8I3MX26_CANLF RUN and SH3 domain containing 2 RUSC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] small GTPase binding [GO:0031267] AELRRSREREG;DANCNSYRPH;DESPRNPGCSGS;KGAGGGGP;KVAGSGSPPLRVSIGDSSQEFSPIQ;QPSPAESK;RPNNANHLSPQALKWREYRRKNP 7 6.4 1.0016 -2.6319 8.89497 5.28555 8.39184 8.52931 0 0 0 0 0 7.57554 0 0 0 0 10.4477 A0A8I3MX28 A0A8I3MX28_CANLF Cell division control protein 42 homolog (EC 3.6.5.2) CDC42 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; Cdc42 protein signal transduction [GO:0032488]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; modification of synaptic structure [GO:0099563]; positive regulation of cellular component organization [GO:0051130]; regulation of filopodium assembly [GO:0051489] centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane-bounded organelle [GO:0043227]; midbody [GO:0030496]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] YPQTDVFLVCFSVVSPSSFE 1 12 0.94872 0.050028 0 0 0 0 0 0 0 0 0 0 0 0 0 9.6069 0 A0A8I3MX32 A0A8I3MX32_CANLF Solute carrier family 25 member 29 SLC25A29 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] VGAWRPPRSAEPWTR 1 2.5 0.95088 0.053901 0 0 0 0 0 0 7.27445 0 0 0 0 0 0 0 0 A0A8I3MX42 A0A8I3MX42_CANLF Transmembrane protein 248 TMEM248 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AQDYNPFWCYKGAIGK 1 5.1 0.98225 -0.25112 0 0 0 0 0 0 0 0 0 0 0 0 9.88541 9.90539 0 A0A8I3MX44 A0A8I3MX44_CANLF Fibronectin type III domain containing 7 FNDC7 Canis lupus familiaris (Dog) (Canis familiaris) AETQAGRSLPS;QSPLGDVVNYT;TVEWATVPGATSYLL 3 5 0.9909 -0.20951 6.9956 0 0 0 0 0 0 0 0 0 0 0 9.74347 0 0 A0A8I3MX47 A0A8I3MX47_CANLF F-box/LRR-repeat protein 15 FBXL4 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005] DDDYEEKDGC;GLKRLVLYR;ILACSANPYSPIPPAEVRWEILWSE;IQLILNHLTLPD;RTLDLWRSNRSVC 5 12.1 1.0031 -1.6245 0 0 9.20469 0 0 0 10.372 0 0 0 0 0 11.8112 0 0 A0A8I3MX50 A0A8I3MX50_CANLF Exostosin glycosyltransferase 2 ACCS Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520]; biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GIPFLSGGAGFFIWV;RQSQEPRSQH 2 5 0.98923 -0.2147 0 0 0 0 0 0 0 10.216 0 0 8.11265 0 0 0 0 A0A8I3MX63 A0A8I3MX63_CANLF Calcium homeostasis modulator family member 6 CALHM6 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] LTWVAVALLGGAFYEC 1 5 0.98618 -0.25829 0 0 0 0 8.38918 0 0 0 0 0 0 0 0 0 0 A0A8I3MX66 A0A8I3MX66_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2B2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480] intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density membrane [GO:0098839] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165] AYSVKKMMK;DPVRPEVP;DTDLEEDAALKQN;EEIPEEELNEDVEEIDHAE;EGCATAQGGAEDEGEAEAGWIEG;LVMSAITVII 6 6.8 0.98817 -0.49405 0 0 2.03171 8.31592 0 0 0 7.00832 0 0 0 0 0 10.5494 0 A0A8I3MX68 A0A8I3MX68_CANLF V-type proton ATPase subunit ATP6V0D1 Canis lupus familiaris (Dog) (Canis familiaris) vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034] "early endosome [GO:0005769]; lysosomal membrane [GO:0005765]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" ITGTLHQRSIAELVPKCHPLGS 1 6.8 0.9738 0.046925 0 0 0 0 0 0 7.96052 0 0 0 0 0 0 0 0 A0A8I3MX71 A0A8I3MX71_CANLF Target of rapamycin complex subunit LST8 (Protein GbetaL) (TORC subunit LST8) (mLST8) (G protein beta subunit-like) (Mammalian lethal with SEC13 protein 8) MLST8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of actin filament polymerization [GO:0030838]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of TOR signaling [GO:0032008]; TORC1 signaling [GO:0038202] lysosomal membrane [GO:0005765]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932] protein serine/threonine kinase activator activity [GO:0043539] EDGRWMYTGGED;PVILATAG;VQHQDSQVNALEITPDRSMI;WMWGCAFSGD 4 15.3 1.0034 -1.6166 6.4407 0 0 0 0 0 8.63361 0 9.38797 0 8.24246 0 0 0 0 A0A8I3MX84 A0A8I3MX84_CANLF Zinc finger protein 296 ZNF296 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of dendrite development [GO:2000171]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DKHLRQKH 1 1.7 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.82623 A0A8I3MX88 A0A8I3MX88_CANLF Rap guanine nucleotide exchange factor 6 RAPGEF6 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] HCRECKNFNS;IVVENSKDNEDSILQ;KESQLSMLQLSTIE;LCSDEDAQELVKESQ;SSSSHDNFQSLP;VEPSSKAADAGLKRGDQIMEVNGQ 6 5.7 0.99107 -0.13464 0 0 0 0 0 0 0 9.31529 0 0 0 0 0 0 0 A0A8I3MX98 A0A8I3MX98_CANLF Thioredoxin domain-containing protein TXNDC2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] protein-disulfide reductase activity [GO:0015035] EKQEKANQES 1 2.2 0.99884 -0.61146 0 0 5.10115 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MX99 A0A8I3MX99_CANLF DnaJ heat shock protein family (Hsp40) member C21 DNAJC21 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GYGDDEKGFYTVYRNVFEM;TVVHPFYAYWQSF 2 6 0.91723 0.10928 0 8.55371 0 0 0 0 0 0 0 0 0 7.25333 0 0 0 A0A8I3MXA4 A0A8I3MXA4_CANLF RNA polymerase I subunit G POLR1G Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase I promoter [GO:0006361] cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736] ALVPTKKRKKKEKW;ELWLIQAPVDFVPDC;FTATSPASEPTRFSLEA;PQGSLRIFDSP;SSKKKKKKE;VLKPAAAE;VLKPAAAEA 7 13.3 1.0023 -1.2272 5.56873 0 0 8.76587 0 7.9582 0 8.40314 0 0 0 0 0 0 5.47612 A0A8I3MXA7 A0A8I3MXA7_CANLF KIAA1522 KIAA1522 Canis lupus familiaris (Dog) (Canis familiaris) ADDPGGPGG;EDALSIRSEMIQRK;EVVEALSAPETA;KKPPKAPPPVA;PASVRSLGRFSSASSP;QMVRLRSVGTSGVAPSSASG;SIVDEHQDNVFFPSG;SKGGSEGG;VPPPGAPI 9 10.2 0.99908 -3.1156 0 11.021 9.21842 6.765 0 8.3831 11.7508 11.5583 11.2954 0 0 0 9.41149 9.98954 9.9928 A0A8I3MXB5 A0A8I3MXB5_CANLF Cms1 ribosomal small subunit homolog Canis lupus familiaris (Dog) (Canis familiaris) ATKTRRRRKKKI;ESLEIFGGDSL;NLPDSCFLKANDLTHSL;PSKINVCC;STKEDATKTRRRRKKK;TKIKLSFANFSV 6 20.3 0.9941 -0.025782 0 0 0 7.48059 5.2607 0 0 2.54451 0 7.83302 7.4048 7.22891 0 9.84609 9.25297 A0A8I3MXC3 A0A8I3MXC3_CANLF Iron-sulfur cluster assembly factor IBA57 IBA57 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] GVALPLESN;LESNLAFMNGV;LYKIRRKVK;MNGVSFTKGCYIGQELTARTHH 4 12 1.002 -0.90832 0 9.46473 0 7.56849 0 7.87252 8.13827 0 8.67782 0 0 7.13924 3.39163 0 7.24584 A0A8I3MXC6 A0A8I3MXC6_CANLF ATR interacting protein ATRIP Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077] AAETDTDDPEMDCS;FPAAAVPD;TEPGYKCIVGREE 3 4.6 1.0017 -1.2939 0 0 0 0 0 0 0 13.8023 8.95574 4.75718 0 0 9.7085 9.54944 9.61283 A0A8I3MXD5 A0A8I3MXD5_CANLF 60S ribosomal protein L41 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] RRLKRKRRKM 1 40 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.95309 A0A8I3MXE2 A0A8I3MXE2_CANLF Intraflagellar transport 27 IFT27 Canis lupus familiaris (Dog) (Canis familiaris) cochlea development [GO:0090102]; inner ear receptor cell stereocilium organization [GO:0060122]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; nucleus [GO:0005634]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] GTP binding [GO:0005525]; GTPase activity [GO:0003924] HHLYREKVE;LAGDSAVG 2 9.1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 9.44077 0 0 0 0 0 A0A8I3MXG6 A0A8I3MXG6_CANLF ceramide glucosyltransferase (EC 2.4.1.80) UGCG Canis lupus familiaris (Dog) (Canis familiaris) cornified envelope assembly [GO:1903575]; establishment of skin barrier [GO:0061436]; glucosylceramide biosynthetic process [GO:0006679]; intestinal lipid absorption [GO:0098856]; keratinocyte differentiation [GO:0030216]; leptin-mediated signaling pathway [GO:0033210]; neuron development [GO:0048666]; regulation of signal transduction [GO:0009966] Golgi membrane [GO:0000139] ceramide glucosyltransferase activity [GO:0008120] ATDKQPYSKLPGVSLLKPLKGVDPN;DIMVFFMCHCL;VAWFIRES 3 11.2 1.0024 -0.7397 0 0 0 0 0 0 0 7.84046 0 0 0 0 0 8.61073 0 A0A8I3MXH3 A0A8I3MXH3_CANLF tetrahydrofolate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (Tetrahydrofolylpolyglutamate synthase) FPGS Canis lupus familiaris (Dog) (Canis familiaris) glutamate metabolic process [GO:0006536] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326] DTSSFGVSLLPIC;LDQVLLRCLAHQQHWSHLN;PELFTKHFWHLYH 3 6.7 0.8574 0.16913 5.78521 7.52458 8.56335 0 0 0 9.54707 10.2765 0 0 0 0 0 0 0 A0A8I3MXI4 A0A8I3MXI4_CANLF VWFD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASSPAAPTKTVHSTGP;CDYYNTHTHEDGAYQYNQDANCTWH;CGCDTTGDCEC;CGCDTTGDCECL;CVQDACGCDTTGDC;ISTAPDRGWCST;KGVCVDWRTPDFCPIYCDYY;MSASSTSSVTTTSHLVI;SMFSSAMQSTARSTEHT;TDGCGANN;TFGAACAP;TPSPHSTPTH;TPSPSPHSPS;VLDDISRN;VYQACNYEK;YEACVQDACGCDTTGDCECLCDA 16 9.7 0.99677 -4.6567 0 0 8.14771 8.22154 0 6.11763 4.7667 5.50821 0 9.94875 7.84141 8.03436 3.27824 0 8.75532 A0A8I3MXI7 A0A8I3MXI7_CANLF Nucleosome assembly protein 1 like 1 NAP1L1 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDYDEEGEEADEEGEEE;DDDDYDEEGEEA;EADEEGEEEGDEENDPDYDS;EAIEDDDDDYDEEGEEADEEGEEEG;EDDDDDYDEEGEEADEEGEE;GEAIEDDDDDYDE;VLYFTGEAIEDDD 7 12.7 0.58482 0.36382 0 7.26303 7.15259 5.90831 7.75782 0 0 4.14967 6.01645 0 0 7.72567 0 7.19584 8.01926 A0A8I3MXK3 A0A8I3MXK3_CANLF Ribosomal protein S6 kinase A2 RPS6KA2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] AEYAVKVYDDGKFVYLVMELM;CVHKATEAEYAVKV;GVPPSANA;ILARIGSGKYAL;TIEYMAPEVVNRR 5 8.7 0.98758 -0.40063 0 0 10.4775 0 0 0 0 10.6519 0 0 0 7.05561 10.6984 0 5.97577 A0A8I3MXK4 A0A8I3MXK4_CANLF Serine incorporator 2 SERINC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGCCPSSP;VGQGRAFDN;VGSFLFILI;WTAVWVKICASWA 4 8.6 1.0015 -2.6531 0 7.38664 0 0 7.71445 0 4.09153 9.2538 0 0 0 0 0 0 0 A0A8I3MXK7 A0A8I3MXK7_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKA Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] cytosol [GO:0005829] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509] AHRFHIMREKY;HVWVRGGCVSGRCDRC;LSLHSTAT;SLVGLHCV;WMQSPCTVSIACACP 5 7.9 1.0022 -1.4174 10.0752 10.4561 4.67841 0 0 0 11.5353 0 11.4717 0 0 0 5.28666 13.3157 0 A0A8I3MXL1 A0A8I3MXL1_CANLF Sperm associated antigen 6 SPAG6 Canis lupus familiaris (Dog) (Canis familiaris) DTLVICLEDFD;EDHIKAAAAWALGQIGRH;GDPCRRSS;HNAELSQAVVDAGAVPL;QTVVDVGAIAHLAQMILNPD 5 11.4 1.0047 -1.1044 0 0 0 0 0 0 10.5315 0 0 0 0 0 0 0 0 A0A8I3MXP1 A0A8I3MXP1_CANLF "Atypical kinase COQ8A, mitochondrial (Chaperone activity of bc1 complex-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3)" COQ8A Canis lupus familiaris (Dog) (Canis familiaris) ubiquinone biosynthetic process [GO:0006744] membrane [GO:0016020] CACACMCM;EFHFMQTDPNWSNFFYDPQQHKVA;GAALKLGQML;LFEFHFMQTDPNWSNFFYDPQQH;VGSDEVCG 5 9.3 1.0036 -2.2088 0 0 0 0 0 5.18551 0 0 8.99693 0 0 0 0 0 0 A0A8I3MXP4 A0A8I3MXP4_CANLF Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) CMTR2 Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483] AELMTFSCSLLHDGDP;FLKRHEECC;GAFIASLNHYLKSHRFPCDWSW;GDPIYQQLFLDCLLHSLQQLHTGDV;LHWWYFGP;NRYFKTYNERKMLE;YFKTYNERKMLES 7 12 1.0023 -1.7555 0 7.44477 0 9.63401 0 0 0 5.58433 9.39064 0 0 0 0 0 7.54597 A0A8I3MXP6 A0A8I3MXP6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] KYVVKLKVL;PEKKYVVKLKVL;PMEQCCDDDT 3 20.4 1.0032 -1.7382 0 0 0 0 0 0 0 0 5.37851 0 0 0 0 6.8535 0 A0A8I3MXP9 A0A8I3MXP9_CANLF SRY-box transcription factor 21 SOX21 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; hair follicle development [GO:0001942]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell differentiation [GO:0048863] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GYPTAGAGAFHG 1 4.3 0.95357 0.05044 0 0 0 0 0 0 0 8.56891 0 0 0 0 0 0 0 A0A8I3MXQ3 A0A8I3MXQ3_CANLF ORAI calcium release-activated calcium modulator 2 ORAI2 Canis lupus familiaris (Dog) (Canis familiaris) store-operated calcium entry [GO:0002115] plasma membrane [GO:0005886] store-operated calcium channel activity [GO:0015279] LNVPVDPS;VDARRQPGPPP 2 7.5 0.99572 -0.017052 0 0 0 8.84408 0 0 0 0 0 0 0 9.89654 0 0 0 A0A8I3MXS5 A0A8I3MXS5_CANLF G-patch domain containing 8 GPATCH8 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] APDLEHFPSYAPPS;DAGEPNKIKEGG;DDSYSDYSDRS;GTSATATCGPGSEFST;KAGLKLKDP;PSKKERSGKSHRHKKKKKHK;RVLEVEKEDTEELR;SQSPHYFRSGRGEG;TFLASHPIHI;VLPLIGKLPATRKPTTKKC;YSEEEEEEEDSGS 11 10.1 1.001 -0.92229 0 10.9527 0 0 0 0 10.7424 8.27947 6.79883 13.997 0 0 7.12216 0 0 A0A8I3MXS6 A0A8I3MXS6_CANLF ATPase cation transporting 13A2 ATP13A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type ion transporter activity [GO:0015662] CKNEEAVSAQLASPRALN;VIEIRDKEDNSWQL;YLFRGQRYVWIESQQ 3 3.8 0.99395 -0.1314 0 8.18468 0 0 9.43557 0 0 3.97691 0 9.17951 0 0 0 0 0 A0A8I3MXT0 A0A8I3MXT0_CANLF "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein)" FABP3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] LEPHPVGYH 1 3.8 0.99475 -0.15896 0 0 0 0 0 10.1167 0 0 0 0 0 0 0 0 0 A0A8I3MXT7 A0A8I3MXT7_CANLF Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1) FITM1 FIT1 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet formation [GO:0140042]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890] endoplasmic reticulum membrane [GO:0005789] coenzyme A diphosphatase activity [GO:0010945]; diacylglycerol binding [GO:0019992]; triglyceride binding [GO:0017129] LMAEEAAVFAKYLAHGLPAGAPL;RLVFLLNVLLLGLWNFL;VGAAVGTFAWYL 3 17.8 0.99203 -0.17662 0 4.11761 0 0 0 0 0 0 7.87909 0 0 0 0 0 7.57297 A0A8I3MXU5 A0A8I3MXU5_CANLF Tubulin gamma complex associated protein 6 TUBGCP6 Canis lupus familiaris (Dog) (Canis familiaris) microtubule nucleation [GO:0007020] centrosome [GO:0005813]; cytoplasm [GO:0005737]; gamma-tubulin ring complex [GO:0000931]; microtubule [GO:0005874]; spindle pole [GO:0000922] gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017] AEQYRLEQY;ALSPGLAH;EADRLERLLA;EGCLSRYSGIFSFLLQ;EGCLSRYSGIFSFLLQLKLM;EHEPQLPAET;LAAHVSLV;PHLEDFLLRI;SIQDFLPTAGEAEQP;SPPDHVSQSGLSLGAQ;SQFSLQPVLDSSCGKGLVFQ 11 7.4 1.0014 -2.6858 7.75989 0 0 7.50184 7.96457 10.1789 0 3.74545 0 0 9.6904 7.42585 0 0 0 A0A8I3MXU7 A0A8I3MXU7_CANLF [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) SMYD3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to dexamethasone stimulus [GO:0071549]; establishment of protein localization [GO:0045184]; myotube cell development [GO:0014904]; nucleosome assembly [GO:0006334]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; nucleoplasm [GO:0005654] histone H3K36 dimethyltransferase activity [GO:0140954]; histone H4 methyltransferase activity [GO:0140939]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162] DQYCFECDC 1 2.1 1.0039 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.82965 A0A8I3MXU9 A0A8I3MXU9_CANLF Rubicon like autophagy enhancer RUBCNL Canis lupus familiaris (Dog) (Canis familiaris) autophagosome maturation [GO:0097352]; autophagosome-endosome fusion [GO:0061910]; autophagosome-lysosome fusion [GO:0061909] autophagosome membrane [GO:0000421] phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314] DDFVVVELGE;DLHLFSLEDLVRVKKRLLVPL;EDLVRVKKRLLVPLLKDIL;FCDCCHTYADSC;IREAEDWEPPRFQIIFDVHPPLKR;LRYCDYLGKYFCDCCHTYADSCIPA;LVRVKKRLLVPL;LVRVKKRLLVPLL;LVRVKKRLLVPLLKDIL;LVRVKKRLLVPLLKDILKASL;PAQEGAVQ;PRHLTDDLHLFSLE;SPRGIHCVVQAQVQT;TCGCSCSSS;YVADMIIAAME 15 20.2 1.0028 -0.77983 0 7.35922 5.75403 10.8081 3.61789 0 0 0 6.8392 0 8.10554 8.48244 0 4.43222 5.9688 A0A8I3MXV0 A0A8I3MXV0_CANLF Uncharacterized protein LOC102151838 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ESYHDWDDCEKPFNQ;SSGCWYGMEDE;TRESYHDWDDCEKPF 3 5.5 0.87316 0.14324 6.71617 0 0 0 0 4.71825 0 5.02614 0 0 0 0 0 0 0 A0A8I3MXV1 A0A8I3MXV1_CANLF Guanylyl cyclase-activating protein 2 (Guanylate cyclase activator 1B) GUCA1B Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cone photoreceptor outer segment [GO:0120199]; photoreceptor inner segment [GO:0001917] calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048] LVDENGDGQL;VEAIYKLKK 2 9.5 1.0017 -0.95446 0 0 0 0 0 10.1908 0 0 0 0 0 0 0 0 0 A0A8I3MXW2 A0A8I3MXW2_CANLF Uncharacterized protein FAM163A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DADEEEEEHD 1 6.1 0.99913 -0.61146 5.4524 0 6.53057 0 0 0 0 0 0 0 5.44205 0 0 0 0 A0A8I3MXX1 A0A8I3MXX1_CANLF Uncharacterized protein LOC100855990 Canis lupus familiaris (Dog) (Canis familiaris) SEAIYQDVAQVCELQK 1 5.7 0.99352 -0.021014 0 0 0 0 0 0 0 0 0 13.389 0 0 0 0 0 A0A8I3MXX9 A0A8I3MXX9_CANLF URI1 prefoldin like chaperone URI1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] AFSGTVIE;NEVTVLLGDNWF;RENSVCSDTSESSAADFDDKR 3 7.7 1.0022 -1.296 0 8.01179 0 0 0 0 0 0 0 8.90144 0 4.9028 0 0 0 A0A8I3MXY0 A0A8I3MXY0_CANLF C-C motif chemokine receptor 7 CCR7 Canis lupus familiaris (Dog) (Canis familiaris) homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; mature conventional dendritic cell differentiation [GO:0097029]; myeloid dendritic cell chemotaxis [GO:0002408]; negative regulation of interleukin-12 production [GO:0032695]; negative thymic T cell selection [GO:0045060]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation [GO:2000526]; positive regulation of humoral immune response [GO:0002922]; positive regulation of hypersensitivity [GO:0002885]; positive regulation of immunological synapse formation [GO:2000522]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of T cell costimulation [GO:2000525]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of interleukin-1 beta production [GO:0032651]; regulation of type II interferon production [GO:0032649]; response to lipopolysaccharide [GO:0032496] external side of plasma membrane [GO:0009897]; mitochondrion [GO:0005739] C-C motif chemokine 19 receptor activity [GO:0038117]; C-C motif chemokine 21 receptor activity [GO:0038121]; chemokine (C-C motif) ligand 19 binding [GO:0035757]; chemokine (C-C motif) ligand 21 binding [GO:0035758] ERNKAIKVIIAVVVVFI;FKDLGCLSQEQLRQW;ITYSLACVRCCVNPFLY;LVIFQVCLCQD;TPELLYSGLQKSSSEQAL;YIYFKRLKTMTDTYLL 6 24.8 0.99289 -0.0076729 0 9.2046 0 5.82197 7.76315 0 0 0 7.28983 7.73159 0 0 0 0 0 A0A8I3MXY9 A0A8I3MXY9_CANLF Zinc finger protein 211 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ILGNILHLAEHQGTYLGEKP;KQFFVAANLQQYQ;SEETGKDFLA 3 7.9 0.98741 -0.33788 0 0 0 0 8.49478 0 0 0 9.8953 0 0 0 0 5.1102 0 A0A8I3MXZ0 A0A8I3MXZ0_CANLF Cell migration inducing hyaluronidase 1 CEMIP Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] carbohydrate binding [GO:0030246] EGVELKHMGQ;EKILRLKETMAFVG;EWVQDVEWTQWFDYDK;GAWLRGGDVWLDSC;VGQYPIHFH;VGYNSLGHC;VWLDSCRFADNGI 7 6.1 0.93811 0.060769 0 0 0 0 0 0 0 0 5.02476 0 0 0 0 0 0 A0A8I3MXZ9 A0A8I3MXZ9_CANLF Nonsense-mediated mRNA decay factor SMG9 SMG9 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" LPPERMKHSI;LVDDQMNWCDS;MAHSHLRYKGTLSML;YQIQNRGM 4 8.9 1.0025 -1.8541 0 0 0 10.7901 9.24327 0 0 0 12.7596 0 0 0 0 0 0 A0A8I3MY21 A0A8I3MY21_CANLF MyoD family inhibitor domain containing MDFIC Canis lupus familiaris (Dog) (Canis familiaris) AAAPLTFRAEEEEEEEE;ACCCCCGD;ACCCCCGDEMGDDCN;ACCCCCGDEMGDDCNCP;ACCCCCGDEMGDDCNCPCDM;ACCESSDCLE;ASCGICTSEACCCCCGD;ASCGICTSEACCCCCGDEMGD;CCCCCGDEMGD;CCCCCGDEMGDDCNC;CCCCGDEMGDDCNCPC;CCCCGDEMGDDCNCPCDMD;CCCGDEMG;CCCGDEMGDDC;CCCGDEMGDDCNCP;CCCGDEMGDDCNCPC;CCCGDEMGDDCNCPCDM;CCCGDEMGDDCNCPCDMD;CCCGDEMGDDCNCPCDMDCG;CCGDEMGDDCN;CCGDEMGDDCNCP;CCGDEMGDDCNCPCDM;CCGDEMGDDCNCPCDMD;CCGDEMGDDCNCPCDMDC;CDMDCGIMDACCESSDC;CGDEMGDDCNC;CGDEMGDDCNCPCD;CGDEMGDDCNCPCDMDCG;CGDEMGDDCNCPCDMDCGI;CGDEMGDDCNCPCDMDCGIM;CGICTSEACCCCC;CGICTSEACCCCCGDEM;CGICTSEACCCCCGDEMGDDC;CGICTSEACCCCCGDEMGDDCNC;CNCPCDMDC;CNCPCDMDCGIMDACCE;CPCDMDCGIMDACCE;CTSEACCCCCGD;CTSEACCCCCGDEMGDDCNC;DCNCPCDMDC;DCNCPCDMDCGIMDACC;DCNCPCDMDCGIMDACCESS;DCNCPCDMDCGIMDACCESSDC;DDCNCPCDMDCGIMDACCE;DDCNCPCDMDCGIMDACCES;DDCNCPCDMDCGIMDACCESSDC;DEMGDDCNC;DEMGDDCNCP;DEMGDDCNCPCDM;DEMGDDCNCPCDMDC;DEMGDDCNCPCDMDCGI;DEMGDDCNCPCDMDCGIMDA;DMDCGIMDACCESSDCLEICMECC;EACCCCCG;EACCCCCGDEMGDDCN;EACCCCCGDEMGDDCNC;EACCCCCGDEMGDDCNCP;EACCCCCGDEMGDDCNCPCD;EMGDDCNCPCDMD;EMGDDCNCPCDMDCGIMDAC;EMGDDCNCPCDMDCGIMDACC;EMGDDCNCPCDMDCGIMDACCE;GDDCNCPCD;GDDCNCPCDMD;GDDCNCPCDMDCG;GDDCNCPCDMDCGIM;GDDCNCPCDMDCGIMDACC;GDDCNCPCDMDCGIMDACCESSD;GDEMGDDCNCPCD;GDEMGDDCNCPCDMDCG;GDEMGDDCNCPCDMDCGIM;GQASCGICTSEACCCCCGDEMGDD;ICTSEACCCCCGDEMGD;ICTSEACCCCCGDEMGDDC;ICTSEACCCCCGDEMGDDCNC;IMDACCESSDCLEICMECC;MGDDCNCPCDMDCG;MGDDCNCPCDMDCGI;MGDDCNCPCDMDCGIMDACCE;PCDMDCGIMDACCESSDC;QASCGICTSEACCCCCGDEMGDDCN;SCGICTSEACCCCCG;SCGICTSEACCCCCGDEMGDDCN;SEACCCCCGDEMGD;SEACCCCCGDEMGDDC;SEACCCCCGDEMGDDCN;SEACCCCCGDEMGDDCNC;SEACCCCCGDEMGDDCNCPC;TSEACCCC;TSEACCCCCG;TSEACCCCCGDEMGDDC;TSEACCCCCGDEMGDDCNC 92 16.5 0.99678 -7.9621 9.40126 8.34798 10.5658 10.8695 10.9919 10.4762 10.5279 12.3134 9.25743 10.7332 8.85848 8.35953 11.885 10.1762 10.0767 A0A8I3MY29 A0A8I3MY29_CANLF Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2) TRIM2 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DTLLEGQESIKSCSNF;KEKKRKEKKRKKRKEKKRKKR;KEKKRKEKKRKKRKEKKRKKRKGK;PARSCQGNGESAGTGSP;RKKERKGKEEKKRKEKKRKEKKRKK;SICLERYK;VGTKGRNKGE 7 7.2 1.0031 -1.3333 0 13.8444 6.26602 0 8.07361 0 15.6746 0 13.5762 0 13.9676 8.11754 10.3049 8.85493 0 A0A8I3MY49 A0A8I3MY49_CANLF Ras association domain family member 6 RASSF6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065]; signal transduction [GO:0007165] SATPRRESKHSQ 1 3.1 0.94173 0.05044 0 8.72315 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MY58 A0A8I3MY58_CANLF Polyamine modulated factor 1 binding protein 1 PMFBP1 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] cytoplasm [GO:0005737] GKSAICQKKKQQPDTI;LLQEKDEMLHELE;LRQLQQLKKKLLALQ;MLAAKEEQLRAFQEEMTALK;TQLDSSLSKQNASQQVIQELNN;YEEEMGNHNENTGE;YIQTMVSK 7 10.5 0.98403 -0.24326 9.44155 0 0 9.36374 0 0 0 0 10.9028 0 8.76597 5.31922 0 8.73006 10.0847 A0A8I3MY65 A0A8I3MY65_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGHGGVNGPRVVFDG;HLLLLLLLLLLLG;HPLSGDVVLGEVDLHHR;IKGKDVLHKLRVIVIPVGHL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLGTAP;LLLLLLLLLL;LLLLLLLLLLL;RLLLLLPK;RLLLLLPKVIVS;VLHKLRVIVI 12 9.5 1.0011 -0.93467 0 7.44377 0 0 12.8576 0 0 4.0635 7.85898 0 0 0 5.30852 0 0 A0A8I3MY68 A0A8I3MY68_CANLF Albumin ALB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion starvation [GO:0072732]; negative regulation of mitochondrial depolarization [GO:0051902] endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; exogenous protein binding [GO:0140272]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; protein-folding chaperone binding [GO:0051087]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643] CCATDDPPTC;DLPSLAAD;DLPSLAADFVEDK;EEGPKLVAAAQAALV;EFKPLVDEPQ;EGPKLVAAAQAAL;EGPKLVAAAQAALV;EKLGEYGFQNALL;EPQNLVKTN;ETYVPKEFNA;ETYVPKEFNAE;EVDETYVPK;EVPEVPEMLEVP;EYGFQNAL;EYGFQNALL;EYGFQNALLVRY;FGAFVEKCCAAENKEGCF;FQNALLVRY;FSEEGPKLVAAAQAALV;GEYGFQNALL;GEYGFQNALLVRY;GFQNALLVRY;GPKLVAAAQAAL;GPKLVAAAQAALV;KAPQVSTPTL;KLGEYGFQNAL;KLGEYGFQNALL;KLVAAAQAALV;KPLVDEPQ;LEVDETYVPKEF;LEVDETYVPKEFN;LEVDETYVPKEFNA;LEVDETYVPKEFNAE;LEVDETYVPKEFNAETF;LGEYGFQNALL;LPSLAADF;LVAAAQAALV;LVKTNCELFEKLGEYGFQNALLVRY;LVRYTKKA;LVRYTKKAPQVS;LVRYTKKAPQVSTPTL;PKLVAAAQ;PKLVAAAQA;PKLVAAAQAA;PKLVAAAQAAL;PKLVAAAQAALV;QNDRLLFFWETRYLYEIARRHPYFY;RDELPGDLPSLAAD;SEEGPKLVAAAQAALV;SVARLSQRFPKAD;SVARLSQRFPKADF;TKKAPQVSTPTL;TYVPKEFN;TYVPKEFNA;TYVPKEFNAE;TYVPKEFNAET;TYVPKEFNAETF;TYVPKEFNAETFTFHA;VAAAQAALV;VELLKHKPKATD;VEVSRKLG;VEVSRKLGKVG;VGQNDRLLFFWETRYLYE;VPEVPEMLEVPEVPEALEMPEVP;VPKEFNAE;VRYTKKAPQVSTPTL 66 38 0.86811 0.18074 9.93035 7.90629 0 0 0 0 9.35078 6.55098 5.85935 0 0 0 0 0 0 A0A8I3MY73 A0A8I3MY73_CANLF Uncharacterized protein IFNGR1 Canis lupus familiaris (Dog) (Canis familiaris) type II interferon-mediated signaling pathway [GO:0060333] membrane [GO:0016020] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] EDLFSETEVVTTE;IEDEDDCNETQC;IVAALLLFLVLILVF;TVQVKNYG 4 10.1 0.99329 -0.27933 0 0 0 0 0 0 10.5788 0 0 0 8.13965 0 0 0 4.47385 A0A8I3MY77 A0A8I3MY77_CANLF Kinesin light chain KLC4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ALRSQKQGTDPISQTKVAELL;EHQAVLQSLSHTIE;ERTSGRGHPD 3 8.3 0.98908 -0.5189 0 0 0 8.84825 0 0 0 9.39765 0 0 0 0 0 0 0 A0A8I3MY91 A0A8I3MY91_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) PPPPTPPP;VVPSDGLWF 2 1.7 0.99142 -0.18251 0 8.01056 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MY94 A0A8I3MY94_CANLF DnaJ homolog subfamily C member 25 DNAJC25 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] membrane [GO:0016020] EETRKDYDYMLDHPEEYYSHYYHYY;LALLPPLLLALLLARPAGALVEG;YHYYSRRL 3 14.5 1.0024 -1.0226 0 0 0 0 0 0 0 11.5606 0 0 0 6.95606 0 0 0 A0A8I3MYA4 A0A8I3MYA4_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) IRF9 Canis lupus familiaris (Dog) (Canis familiaris) CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; T cell receptor signaling pathway [GO:0050852] CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797] identical protein binding [GO:0042802]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] DAPAYHARLLQCYHFLS;LETAAERYLHVRP;RYWRGVKFNNPVF;WYCIHCTFCNSGP 4 4.9 0.98688 -0.39835 0 0 0 0 0 0 0 12.7623 12.4974 0 11.6525 0 9.57733 0 0 A0A8I3MYA8 A0A8I3MYA8_CANLF Dystrobrevin alpha DTNA Canis lupus familiaris (Dog) (Canis familiaris) synaptic signaling [GO:0099536] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; synapse [GO:0045202] zinc ion binding [GO:0008270] DSITNTMSSL;HPVECSYCHSESMMGF;PEKAQQNPTL;VECSYCHSESM;VECSYCHSESMMGFRYRCQ;VIEALRENALNNLD 6 7.4 1.0031 -1.0278 0 0 8.30998 0 5.99494 0 10.6405 0 6.20463 4.35607 0 3.98932 4.33735 9.37628 0 A0A8I3MYA9 A0A8I3MYA9_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCD3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipid catabolic process [GO:0016042]; regulation of cell population proliferation [GO:0042127] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] phosphatidylinositol phospholipase C activity [GO:0004435] GHTLTSKILFRDVV;LSDQEEEEEEEEE;TPVALAPPDGGSRRPG;VLSAPELLEFLEDQG;VLVKGKKLP 5 8.6 0.99202 -0.13287 12.3942 0 8.59541 7.7449 12.1795 0 0 0 0 0 8.79497 0 7.84153 0 0 A0A8I3MYB4 A0A8I3MYB4_CANLF Amyloid beta precursor protein binding family A member 3 APBA3 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; in utero embryonic development [GO:0001701]; regulation of gene expression [GO:0010468] perinuclear region of cytoplasm [GO:0048471]; synapse [GO:0045202] enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857] AHTEVHIKT;GSVLVLMARRRLARRPASQ;RRPHAREQLGF 3 6.7 1.0028 -0.7192 0 9.71807 0 0 0 0 0 0 0 7.16932 6.93664 9.71383 0 0 8.20731 A0A8I3MYB8 A0A8I3MYB8_CANLF "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2)" GFM2 EFG2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543]; ribosome disassembly [GO:0032790] mitochondrion [GO:0005739] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ERISRLLLPFADQHIEIPSL;GVEIPEPVFFCTI;IRAILKRLKPYVPPGR;KETTEARNALIE;VEAQTLTVWRQAD;VLDGAVAVFDASAGVEAQT;VLGEFSENF 7 13.2 0.991 -0.19499 0 0 9.10559 0 10.6569 9.61016 0 8.87043 11.305 0 0 0 0 0 0 A0A8I3MYC9 A0A8I3MYC9_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT10 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] EIWGGEQYEISFKVWMCGG;GSGAAVVP;LYHPVSGSCMDCSESDH;SCMDCSESDH;VDRKWFWELG 5 10 1.0033 -2.2811 0 0 0 0 0 0 4.91413 0 0 0 0 0 10.2136 0 0 A0A8I3MYD3 A0A8I3MYD3_CANLF Uncharacterized protein EPGN Canis lupus familiaris (Dog) (Canis familiaris) CLEDHNSYCINGVCA;LTQEAAVPGTP 2 25.5 0.93786 0.089369 0 0 0 0 0 8.67804 0 0 4.60567 0 0 0 0 0 6.8071 A0A8I3MYD7 A0A8I3MYD7_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KA2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; ribosomal protein S6 kinase activity [GO:0004711] EDTVEEEEGTVKEIDI;GVPPSANA;ILARIGSGKYAL;TIEYMAPEVVNRR 4 6.6 0.95838 0.051277 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1316 A0A8I3MYE1 A0A8I3MYE1_CANLF Uncharacterized protein ZNF398 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] RSGHSGGC 1 1.2 1.0039 -1.1044 0 0 0 0 10.0592 0 0 0 0 10.0176 0 0 0 0 9.5961 A0A8I3MYE5 A0A8I3MYE5_CANLF Rho GTPase activating protein 27 ARHGAP27 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] DEESRRVFFYNPLT;EPEDEPEDALE;EPEDEPEDEPED;FPDPALRSPAQR;KAGCAGAG;LSKVRHRLRKFLLKRP;PEDALEDALEDM;PEEESQSSGADFGS;RVFFYNPLTGEAVWEDE;SEYLIQHDSEAIISTWHKAI;VFFYNPLTGEAVWEDEPEDEP;VGSRESLETDWGQY 12 12.6 1.0022 -0.95581 0 7.72335 7.23716 0 10.1083 0 0 0 11.7967 0 7.85941 5.75852 9.34392 9.69905 0 A0A8I3MYE6 A0A8I3MYE6_CANLF Olfactory receptor OR5M11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLSEKKTISFAGCFTQ;TYVKEHAMLISAG 2 9.4 0.99607 -0.10107 0 0 0 0 0 0 11.3604 0 0 0 0 0 0 10.6078 0 A0A8I3MYE8 A0A8I3MYE8_CANLF Small integral membrane protein 31 SMIM31 Canis lupus familiaris (Dog) (Canis familiaris) IKEEEKKRKESQKK 1 18.7 0.93419 0.060769 7.02735 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MYE9 A0A8I3MYE9_CANLF "DNA-directed RNA polymerases I, II, and III subunit RPABC2 (DNA-directed RNA polymerase II subunit F) (RPB6 homolog)" MICALL1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; neuron projection development [GO:0031175]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis [GO:0006898]; slow endocytic recycling [GO:0032458] "cytoplasmic side of endosome membrane [GO:0010009]; late endosome [GO:0005770]; recycling endosome membrane [GO:0055038]; RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267] EEEEEEEPPAAPSLATGPA;ELKARKIPIII;EVAVGHGAPGAVPEFSGAP;GGAAPTPLLLV;GGGGGGGG;LRPRSGKR;NVFENNRLAFEVA;SEGAAAAS;SEPPSATPSPALSV;SSPQLQVKSSCKENPF;VGRQDPTPRGGGG;VHLVQRYLAE 12 11.5 1.0025 -2.5805 0 0 8.08412 5.52133 6.97418 9.51985 12.9395 0 0 2.61379 0 0 10.3742 9.62998 9.23879 A0A8I3MYG3 A0A8I3MYG3_CANLF Uncharacterized protein ZSWIM7 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] VLGSSGETYT 1 6.9 0.9896 -0.20269 0 10.8694 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MYH0 A0A8I3MYH0_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) ACVR2A Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363] activin receptor complex [GO:0048179] activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] CCCEGNMC;CCCEGNMCNERFSYFPEMEVTQ;EVYFCCCEGNMCN;EVYFCCCEGNMCNE;QEVVVHKKKRPVLR;VLRDYWQKHAGMAML 6 10.1 1.0014 -0.93733 6.5012 0 0 0 0 5.34713 0 0 3.38902 0 0 0 0 3.5208 0 A0A8I3MYH3 A0A8I3MYH3_CANLF Olfactory receptor family 56 subfamily A member 1B OR56A1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CTFMVMAY;QLHYCGKNVIENCICANL;SLLFLLAMGANTTL 3 12.7 0.98709 -0.37967 0 15.052 0 0 0 0 0 0 0 0 0 0 0 0 6.72151 A0A8I3MYJ5 A0A8I3MYJ5_CANLF DnaJ heat shock protein family (Hsp40) member B12 DNAJB12 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to misfolded protein [GO:0071218]; chaperone cofactor-dependent protein refolding [GO:0051085]; ERAD pathway [GO:0036503]; protein-containing complex assembly [GO:0065003] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] Hsp70 protein binding [GO:0030544] AIGTAYAVLSNPEK;RMRYTYQQRQ 2 5.9 0.99796 -0.10424 0 0 0 0 0 0 0 0 0 0 0 0 9.26554 4.16559 0 A0A8I3MYK4 A0A8I3MYK4_CANLF Glutamate receptor GRIA1 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to ammonium ion [GO:0071242]; long-term memory [GO:0007616]; long-term synaptic depression [GO:0060292]; receptor internalization [GO:0031623]; synapse assembly [GO:0007416]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; axonal spine [GO:0044308]; cell surface [GO:0009986]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum [GO:0005783]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; perisynaptic space [GO:0099544]; postsynaptic density membrane [GO:0098839]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672] AMPA glutamate receptor activity [GO:0004971]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:0099583]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] FSFLDPLAYEIWM;LVYGRADVAV;MQQWKNSDARDHTRVDW;TPKGSALRGPVNL 4 5.8 0.98957 -0.52988 0 0 0 0 0 0 0 0 14.1273 0 0 0 7.24336 0 0 A0A8I3MYL1 A0A8I3MYL1_CANLF RING finger protein 145 RNF145 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] zinc ion binding [GO:0008270] LFLTSIAECCSTPYSLLG;LKKWLYVQETCPLCH;NNPLFQYKYLALNMHYV 3 7.5 0.99457 -0.15647 0 0 3.66767 0 0 0 0 8.60851 10.3514 0 0 0 0 0 0 A0A8I3MYL2 A0A8I3MYL2_CANLF "Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase)" MECR Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] mitochondrion [GO:0005739] enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) [GO:0016631] AATLGVNPCTAY;DSSQVTSTPSPL;VGGNEGVGQVVAVGGSVTGVKPGDW 3 9.7 0.98932 -0.31026 0 0 0 0 0 0 11.6077 0 9.35762 0 8.9424 0 0 0 0 A0A8I3MYL3 A0A8I3MYL3_CANLF Transmembrane protein 39B TMEM39B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] EGAVIVYQLYSL;ETWKQHTRQ;GPNRTSYCRNPLCEPGSSGGSGGG;HFRFHFFFSKPLRILNILLL;HYYDKRWSCELFLLVSISTSVILMQ;SYSASPQRDLD 6 20.5 0.95466 0.052108 0 12.7152 0 12.2242 0 0 10.9825 12.7214 6.43866 0 12.4883 12.5883 7.10423 9.39184 0 A0A8I3MYL6 A0A8I3MYL6_CANLF G kinase anchoring protein 1 GKAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] Golgi apparatus [GO:0005794] HKTEYENAENASTQSKVVN;KLKNVITQW;VQKDSREENWQEWRQRDEQLTSEM 3 16.7 0.99226 -0.18094 0 12.6209 0 0 0 5.11483 0 10.4181 0 0 0 0 0 0 0 A0A8I3MYL7 A0A8I3MYL7_CANLF Ankyrin repeat domain 24 ANKRD24 Canis lupus familiaris (Dog) (Canis familiaris) GVGAGEAKP;GVGAGEAKPTDPETAPVEA;QEQLKQAARDHSAV 3 3 0.98501 -0.43759 0 0 0 5.76803 0 0 11.3896 0 0 0 0 0 0 0 0 A0A8I3MYM0 A0A8I3MYM0_CANLF Prepronociceptin PNOC Canis lupus familiaris (Dog) (Canis familiaris) neuron-neuron synaptic transmission [GO:0007270]; neuropeptide signaling pathway [GO:0007218]; sensory perception of pain [GO:0019233] axon terminus [GO:0043679]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; synaptic membrane [GO:0097060] opioid peptide activity [GO:0001515]; opioid receptor binding [GO:0031628] VLHQPSTSEIQL 1 6.9 0.99094 -0.13578 0 0 0 14.3175 14.7506 0 0 0 0 0 0 0 0 0 0 A0A8I3MYM3 A0A8I3MYM3_CANLF Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) MED23 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] HAFAMTCIW;IEEAFPGMFMD;LILKFIFIMFGSYKL;LSQESHEQCIQW;NYMDPICDFLYHMKY;PYLPIYFGN;RDLLKVILEKILTI 7 6 0.95108 0.053874 0 0 0 8.77169 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MYN0 A0A8I3MYN0_CANLF Meiosis initiator MEIOSIN Canis lupus familiaris (Dog) (Canis familiaris) activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] CDFSGCCC;GLPSSSDEDRDCTW;PEGLPSSSDEDRDCTWTPTRRTT;PKKWMTLSPEQQG;SLDHCYLSLSENSKVPS 5 10.2 1.0021 -1.2043 6.7211 0 0 9.11962 0 0 0 0 0 0 6.8535 7.76779 8.25508 0 0 A0A8I3MYN1 A0A8I3MYN1_CANLF Leucine rich repeat containing 74A LRRC74A Canis lupus familiaris (Dog) (Canis familiaris) AEASVAVEKEKPAQE;DETLYCEAEASV;DETLYCEAEASVA;LSIKRNPKSKMEEI;NHFYIRGAVALCN;SEFLQRNTSSLWNLQ 6 13.6 1.0022 -0.66116 0 0 0 0 9.61272 0 0 0 0 10.7983 0 0 9.01302 8.84668 0 A0A8I3MYN8 A0A8I3MYN8_CANLF INO80 complex subunit C INO80C Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382] Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339] PNYFSIDAP 1 4.7 0.99165 -0.18652 0 0 9.1821 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MYP2 A0A8I3MYP2_CANLF "Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase)" MECR Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] mitochondrion [GO:0005739] oxidoreductase activity [GO:0016491] AATLGVNPCTAY;DPHAVRSHR;VGGNEGVGQVVAVGGSVTGVKPGDW 3 11.8 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 8.57713 0 0 0 0 A0A8I3MYP8 A0A8I3MYP8_CANLF Neugrin (Neurite outgrowth-associated protein) NGRN Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] DVIRRVLKSKFVPTLE;YSTSDGVGK 2 8.5 1.0028 -0.75498 0 0 0 0 3.65042 0 0 0 0 8.94927 0 0 0 0 0 A0A8I3MYQ2 A0A8I3MYQ2_CANLF Uncharacterized protein ZNF283 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PAQRDLYVDVMLEN 1 2.2 0.93424 0.060855 0 0 0 0 6.6499 0 0 0 0 0 0 0 0 0 0 A0A8I3MYQ9 A0A8I3MYQ9_CANLF Pyrroline-5-carboxylate reductase 1 PYCR1 Canis lupus familiaris (Dog) (Canis familiaris) L-proline biosynthetic process [GO:0055129] AYAFTALE;EGATVYATGTHAQV;IDAVTGLSGSGPAYAF 3 15.7 0.98922 -0.30961 0 0 0 0 0 0 0 8.15391 0 0 0 0 9.41475 0 0 A0A8I3MYR8 A0A8I3MYR8_CANLF Transcription factor AP-4 TFAP4 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; protein-containing complex assembly [GO:0065003]; regulation of mitotic cell cycle phase transition [GO:1901990]" mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]" RSVRMMLEEQVRSLEA 1 4.7 0.98567 -0.23596 0 0 0 0 0 0 0 0 11.2326 0 0 0 0 0 0 A0A8I3MYS4 A0A8I3MYS4_CANLF Tubby-like protein TULP1 Canis lupus familiaris (Dog) (Canis familiaris) DEDEEEEEEDQEEEEVEE;DEEEEEEDQEEEEVE;EDEEEEEEDQEEEE;PAPKPLRIKK;VLQFGRVAEDAFTLDYRY 5 8.4 0.98766 -0.40019 3.40054 5.76078 0 0 0 0 6.42277 6.89142 0 0 4.23335 0 0 0 0 A0A8I3MYS9 A0A8I3MYS9_CANLF Uncharacterized protein LOC119864477 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634] cAMP response element binding protein binding [GO:0008140] ATSPLNPYPAAQIVS;LAGMPEVGLNMDTPFP;PAFPQQVPLQ;PNLYSNCG 4 9.6 1.0027 -0.73812 0 12.0123 0 0 10.6547 0 10.3732 11.2972 11.8874 0 0 0 0 0 0 A0A8I3MYU2 A0A8I3MYU2_CANLF Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25) EIF3K EIF3S12 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446] eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleus [GO:0005634] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] ERYVETQAKENAYDLEANLAV;ESGQIFICSQEE 2 17.2 0.93665 0.098199 0 0 0 0 0 6.77545 0 7.65313 7.59679 0 0 0 0 0 0 A0A8I3MYU4 A0A8I3MYU4_CANLF Phosphatidylinositol-4-phosphate 5-kinase type 1 beta PIP5K1B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] DTVSVHRPSFYAD;GVCFPSREIGSGPIELVFE;RVFKKIQALKASPSKK;TVQHKEAEFLQKL 4 11.3 0.9926 -0.051515 0 8.97862 0 0 0 0 0 8.75719 0 0 9.6034 0 0 0 9.89239 A0A8I3MYV1 A0A8I3MYV1_CANLF Phosphatidylinositol-4-phosphate 5-kinase type 1 beta PIP5K1B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] DTVSVHRPSFYAD;RVFKKIQALKASPSKK;TVQHKEAEFLQKL;VGNLTSKPDRDVLMQD 4 11.6 0.95479 0.049233 0 0 0 0 0 0 0 0 7.50867 0 0 0 0 0 0 A0A8I3MYV3 A0A8I3MYV3_CANLF Uncharacterized protein LOC484540 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EKPYVCSECGRAFIRKSNF;LSIHQKIH;VGYEVPQPEVFMLEQGKEPWALQG;VHLKVHTGEKLYVCIDCGKAFVK 4 9.6 0.87154 0.13729 0 0 5.52356 0 8.31506 7.17183 0 0 0 0 0 0 0 6.49597 0 A0A8I3MYW1 A0A8I3MYW1_CANLF Sorting nexin 8 SNX8 Canis lupus familiaris (Dog) (Canis familiaris) early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; retromer complex [GO:0030904] identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091] AAEAEADEEADPPAADR;ADREAEAQRSHHWAR;QENAIQTMELRSY;VFHEMLLH;YRRYNDFVVF 5 10.9 1.0039 -1.0752 0 8.94889 0 5.02897 0 0 0 0 0 0 10.614 0 0 0 0 A0A8I3MYW2 A0A8I3MYW2_CANLF Potassium sodium-activated channel subfamily T member 1 KCNT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] DYYVVILCP;ESPEQWQRMYGRCS;GGGGGGGG;GGGGGGGGK;VGSDVGQRVQV 5 3.5 0.98822 -0.22431 0 0 0 0 0 0 0 0 0 0 9.41557 0 0 0 8.78741 A0A8I3MYW4 A0A8I3MYW4_CANLF Small nuclear ribonucleoprotein-associated protein LOC100684393 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] AGDDPTGKRHCGCCCSCC;CGCCCSCC;CGCCCSCCHHQHCRGPDPVPT;HCGCCCSC;HCGCCCSCC;HCGCCCSCCHH;RHCGCCCSC 7 12.4 0.99703 -3.6862 0 6.91337 3.00937 6.95861 0 7.35297 0 4.23151 0 0 5.10178 0 9.42905 4.53568 0 A0A8I3MYX4 A0A8I3MYX4_CANLF Stress-activated protein kinase JNK (EC 2.7.11.24) MAPK9 Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310] NVFTPQKTLEEFQDVYLVMELMDA;VGCIMGELVKGCVI 2 9.8 0.94187 0.062014 0 0 0 0 0 0 0 0 0 0 0 0 0 8.78218 0 A0A8I3MYY1 A0A8I3MYY1_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF19B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytolytic granule [GO:0044194]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KPSHYQLVSGSSTEDSLHVHAQ;MNDGSCNHMTCAVCGCEFCWL 2 6.2 0.97571 0.046883 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.76937 A0A8I3MYY9 A0A8I3MYY9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GRLSWGHGGD;SRLPTEKGVCCA 2 11.1 0.98886 -0.26065 0 13.4256 0 0 0 0 0 0 0 8.8989 0 0 0 0 0 A0A8I3MYZ0 A0A8I3MYZ0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) T cell receptor complex [GO:0042101] peptide antigen binding [GO:0042605] YTVNPFGSL 1 9 1.0036 -0.80421 0 0 0 0 0 9.36021 0 0 0 0 0 0 0 0 0 A0A8I3MYZ3 A0A8I3MYZ3_CANLF Lens fiber membrane intrinsic protein LIM2 Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088] plasma membrane [GO:0005886] structural constituent of eye lens [GO:0005212] LLVVATATDH;VVATATDH 2 5.8 1.003 -1.7158 0 0 0 0 7.83308 0 0 0 0 8.01167 0 8.16133 0 0 10.0419 A0A8I3MYZ4 A0A8I3MYZ4_CANLF Uncharacterized protein ZNF488 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EAFMCPICH;VWPRGAPG 2 4.4 1.0023 -1.3601 0 4.66511 0 0 0 0 0 0 0 0 0 7.60785 0 0 0 A0A8I3MZ02 A0A8I3MZ02_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] AKYTCSFCGKTKMKMRAMGIW 1 31.3 0.95745 0.051019 0 0 0 0 0 0 0 0 7.34908 0 0 0 0 0 0 A0A8I3MZ07 A0A8I3MZ07_CANLF E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (RING-type E3 ubiquitin transferase MARCHF2) MARCHF2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] ALDTSSDGPFCRICHEGANGE 1 11.9 0.93853 0.064754 0 8.37873 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MZ31 A0A8I3MZ31_CANLF Leucine rich repeats and immunoglobulin like domains 2 LRIG2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NAVERISPDAWEFCQRLSELDLSY;TTVGIVII;TYSVEFIFQCMVFPTNLRQ 3 6.9 1.0022 -1.0132 0 0 8.0348 0 9.73159 0 0 0 0 0 0 0 0 0 0 A0A8I3MZ41 A0A8I3MZ41_CANLF Aminopeptidase (EC 3.4.11.-) LVRN Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DRTVGRVPVDDVWFASDMQ;DVNGSMWT;ELQLSFSSLVYQ;LTVHAKLQTIKNKNLE;PLLKKYLLKRLIS;QDDYLALVALE;RAVALLLAGLAAALLLALLVL;TETSEINELFDLFTYNKGA;TTFSTTPPMPTYLVAFAICD 9 14 1.0041 -1.0734 0 6.69474 9.19212 9.72586 0 9.34742 5.75015 9.87024 0 0 0 0 4.89419 0 0 A0A8I3MZ50 A0A8I3MZ50_CANLF Zinc finger protein 24 ZNF24 Canis lupus familiaris (Dog) (Canis familiaris) myelination [GO:0042552]; negative regulation of DNA-templated transcription [GO:0045892] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]" GTLNIGVPQIFKYGEACFPKGR;QEIPSAVESHEVPGTLNI;QLRELCRLWLR;SYSQSSNLFRHQ 4 15.8 0.99367 -0.12033 0 0 0 0 0 6.66959 0 9.51078 0 0 0 0 9.59034 0 5.43393 A0A8I3MZ52 A0A8I3MZ52_CANLF WD repeat-containing protein 89 WDR89 Canis lupus familiaris (Dog) (Canis familiaris) corpus callosum development [GO:0022038]; ventricular system development [GO:0021591] VICAGTEKVD;YLIGGLYH 2 4.7 1.0028 -0.85491 0 0 0 0 0 0 0 9.45146 0 0 0 0 0 10.365 0 A0A8I3MZ57 A0A8I3MZ57_CANLF Zinc finger protein 362 ZNF362 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PAESSQAVMSLPK;SPSGKGHSRM;TSQSRLIASSP 3 8.2 1.0021 -0.66944 0 0 10.1667 0 0 0 0 10.0515 0 9.19242 0 0 0 0 0 A0A8I3MZ58 A0A8I3MZ58_CANLF Rho family GTPase 2 RND2 Canis lupus familiaris (Dog) (Canis familiaris) collateral sprouting [GO:0048668]; positive regulation of collateral sprouting [GO:0048672]; small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] VLICFDISRPETLD;YDNVRPLAYPDSDAVL 2 12.2 0.91171 0.11031 0 0 0 0 0 10.1032 0 0 0 0 0 0 0 0 0 A0A8I3MZ68 A0A8I3MZ68_CANLF Tripartite motif containing 62 TRIM62 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of antifungal innate immune response [GO:1905036]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein K27-linked ubiquitination [GO:0044314]; regulation of viral entry into host cell [GO:0046596]; viral release from host cell [GO:0019076] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EELEADTARTLTDI;KYTGPLQYTIWKSLFQ;TTIGEAFERLHRLLRERQKAM 3 10.7 0.85413 0.15807 0 0 0 0 8.50434 0 0 0 0 7.41996 7.65485 0 0 0 0 A0A8I3MZ71 A0A8I3MZ71_CANLF Target of rapamycin complex 2 subunit MAPKAP1 (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) MAPKAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of cellular response to oxidative stress [GO:1900407] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932] "molecular adaptor activity [GO:0060090]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]" GCCSGGGV;GGVGGGGG;IEIDPVTN;KVTMKEILLKAVKRR;LICWQYTSEGREPKL;QGNVSANPNA 6 11.4 1.0034 -2.1007 0 0 0 0 0 0 10.2496 0 0 0 0 0 9.08794 7.54481 0 A0A8I3MZ75 A0A8I3MZ75_CANLF Divergent protein kinase domain 1B DIPK1B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] GLRVKYVFLVWLGI;VEWRTCLSSVPG 2 6 0.98673 -0.23345 0 0 0 0 0 0 9.88171 0 0 0 0 0 0 0 0 A0A8I3MZ90 A0A8I3MZ90_CANLF Sterile alpha motif domain containing 3 SAMD3 Canis lupus familiaris (Dog) (Canis familiaris) LIFDIHRPYFPSTK;SVLMDLIKKHKQKSQRVWP 2 6.4 0.91434 0.11037 7.84599 0 0 0 0 8.8426 0 0 0 0 0 0 0 0 0 A0A8I3MZ99 A0A8I3MZ99_CANLF Glucagon like peptide 2 receptor GLP2R Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AIFYNSYSRRPNSDKEW;FIFLKIVKLLISKLKA;FLKIVKLLISKL;FLKIVKLLISKLK;FLKIVKLLISKLKAHQMC;NRNKKIWWIIRGPMLL;VLVKDAIFYNSYSRRPNSDKEW 7 8.2 0.98628 -0.3225 9.70254 0 0 0 0 11.8449 8.48414 7.04122 9.61738 0 0 0 0 0 6.46325 A0A8I3MZA9 A0A8I3MZA9_CANLF Kinesin motor domain-containing protein LOC489893 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GGGGDSSQPSALPCPR;LEMRRSLVELENTNIELHV;LETDSGYRSSQGTPSK;PTEEPSDSSLFP;TAAEHGAESQPSPAVL;VLQLTKSSGKSFF;VSMSYLEIYNEV 7 9.5 0.98527 -0.44677 0 8.88658 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MZB0 A0A8I3MZB0_CANLF SPATA31F3-like domain-containing protein LOC119875795 Canis lupus familiaris (Dog) (Canis familiaris) TLTSPSSSGPSQ 1 3.9 0.99006 -0.1964 11.8172 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3MZB7 A0A8I3MZB7_CANLF Patatin like phospholipase domain containing 2 PNPLA2 Canis lupus familiaris (Dog) (Canis familiaris) diacylglycerol biosynthetic process [GO:0006651]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433] cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] diolein transacylation activity [GO:0051265]; mono-olein transacylation activity [GO:0051264]; phospholipase A2 activity [GO:0004623]; triglyceride lipase activity [GO:0004806] ARAGPAPAPAKSP;GVGGGGRGP;LGDALAKWEE;YHIGVASCLRE 4 6.8 1.002 -1.2188 11.2745 9.8061 10.9288 0 0 0 11.1402 10.1885 9.82485 0 0 9.7218 0 10.1819 6.81941 A0A8I3MZC2 A0A8I3MZC2_CANLF CCDC113/CCDC96 coiled-coil domain-containing protein CCDC96 Canis lupus familiaris (Dog) (Canis familiaris) EPPGPRPQPEPEP;GEAGPGESGEPAEAEA;GGGAKGPG;IDFEQLKIENQTFNEKV 4 4.9 1.0021 -1.8332 15.0875 10.8683 0 0 0 8.84194 0 0 0 9.28026 0 2.67347 0 0 3.11493 A0A8I3MZC3 A0A8I3MZC3_CANLF HBS1 like translational GTPase HBS1L Canis lupus familiaris (Dog) (Canis familiaris) DEDFEDDDLYGQSVEDDYCIS;ESFTLSQLGNRYPSSTGISELT;NLNNPLLLTSSLENMAHD;NYDEDFEDDDLYG;SLAELFQEH 5 11.4 1.0023 -1.0132 0 8.54975 0 0 0 0 0 0 7.82445 0 0 0 9.17867 0 0 A0A8I3MZE5 A0A8I3MZE5_CANLF SIM bHLH transcription factor 1 SIM1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] ERSESDHD;PAGEVCHGSALANTSP;TLYHHVHGCDTFHL;YHSHFVQE;YHSHFVQEYEI 5 6.4 1.0027 -2.5741 0 0 0 0 0 0 9.61743 0 0 0 6.3621 9.02406 9.03023 0 0 A0A8I3MZE6 A0A8I3MZE6_CANLF Histone deacetylase 10 HDAC10 Canis lupus familiaris (Dog) (Canis familiaris) homologous recombination [GO:0035825]; macroautophagy [GO:0016236]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mismatch repair [GO:0032425]; spermidine deacetylation [GO:0106048] cytosol [GO:0005829]; histone deacetylase complex [GO:0000118] histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826] CSHLFSWPRNPHPSLQ;GPKAGAKP;LVLVSAGFDSAIGDPEGQM;PPLLLLLL;PPLLLLLLL;RPLLLLFLLL;TPPLLLLLLL 7 6.8 1.0033 -1.1201 0 0 0 9.70596 3.96338 0 11.6086 9.51598 0 0 0 4.2944 10.7469 10.8347 10.6452 A0A8I3MZE8 A0A8I3MZE8_CANLF Ganglioside GM2 activator GM2A Canis lupus familiaris (Dog) (Canis familiaris) ganglioside catabolic process [GO:0006689]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; maintenance of location in cell [GO:0051651]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] beta-N-acetylhexosaminidase activity [GO:0004563]; enzyme activator activity [GO:0008047] DTFIPPGQ;HQRRPPKSGSFFWNNCDRAKDPVL;QVLDTFIPPGQPC 3 18.9 1.0026 -1.3257 0 0 0 8.66881 0 0 0 11.4877 0 0 0 0 0 0 8.02364 A0A8I3MZF9 A0A8I3MZF9_CANLF Endonuclease/exonuclease/phosphatase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VLHLNTTE 1 3.5 1.0048 -1.1044 0 0 0 0 0 6.63998 0 0 0 0 0 0 0 0 0 A0A8I3MZG6 A0A8I3MZG6_CANLF Epithelial membrane protein 3 EMP3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LLLVVSALHILILILLFVATL;VVSALHILILILL 2 12.9 0.92646 0.10673 0 0 0 6.89821 0 0 0 0 0 0 0 0 0 0 6.92303 A0A8I3MZH3 A0A8I3MZH3_CANLF Maestro heat like repeat family member 9 MROH9 Canis lupus familiaris (Dog) (Canis familiaris) HVLKTILLILKGKP;LMIKDRLYARDA 2 3.3 0.99261 -0.17624 0 0 0 0 0 0 0 5.18269 0 12.5327 0 0 0 0 0 A0A8I3MZH7 A0A8I3MZH7_CANLF Conserved oligomeric Golgi complex subunit 3 (Component of oligomeric Golgi complex 3) COG3 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886] VLELKAAAEN 1 1.2 0.99825 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 9.66167 0 A0A8I3MZH9 A0A8I3MZH9_CANLF ST14 transmembrane serine protease matriptase ST14 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] CDGTDNCGDGSDE;GLHDQSKRSATGV;LFWVCDSVNDCGDNSDEQECSCPAQ;LPPIDQNMRVQKIFN;NWLVSAAHCFI;QQCDGTDNCGDGSDEATCDLVRT;SDQSYTDTGFLAEY;YPGHYPPNMNCTW 8 13.3 1.0027 -0.84691 13.2899 0 0 0 5.23867 8.27733 0 3.97682 0 0 0 8.82101 0 0 9.41897 A0A8I3MZI8 A0A8I3MZI8_CANLF Chromosome 1 open reading frame 87 C5H1orf87 Canis lupus familiaris (Dog) (Canis familiaris) ELMTLDPI;SFRKEDRSF 2 3.1 1.0025 -1.3558 9.30615 0 0 0 0 0 0 8.21563 0 0 0 0 0 0 0 A0A8I3MZJ3 A0A8I3MZJ3_CANLF Tripartite motif containing 58 TRIM58 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ASGAPGERLREEARCPVCLDFLQDP;DTIPLTLP;GRHYWEVMVGE;LGLQNFSSGRHYWEVMVGERAEWGL;RGPFALESF;SLVDSVRQLGLGAG;TVVWKEKVE;YNVTNGSYIY 8 20.5 0.99704 -4.0827 0 10.7819 0 9.90676 5.51485 0 0 0 7.81237 9.84433 0 0 0 0 9.78449 A0A8I3MZJ7 A0A8I3MZJ7_CANLF VPS26 retromer complex component B VPS26B Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; retromer complex [GO:0030904] IKIKHMEIDI;IVGKIYFLLVRIKIK;KDVIVGKIYFLLVRIKIKHMEID;LLVRIKIKH;LVRIKIKHMEI;VIVGKIYFLLVRIKIKH 6 7.1 1.0018 -1.2744 0 5.13976 0 0 0 0 0 3.76607 0 0 0 0 4.8214 0 7.50303 A0A8I3MZK5 A0A8I3MZK5_CANLF Protein phosphatase 6 regulatory subunit 2 PPP6R2 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase binding [GO:0019903] CCCGGTCP;TEQVILFLKKK 2 8.1 1.0036 -1.1044 8.39832 8.12205 0 0 0 0 0 0 0 0 8.36129 8.77106 7.71445 0 0 A0A8I3MZN6 A0A8I3MZN6_CANLF Interphotoreceptor matrix proteoglycan 1 (Sialoprotein associated with cones and rods) IMPG1 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] heparin binding [GO:0008201]; hyaluronic acid binding [GO:0005540] AKASASLSDTLPFFTASSIF;VKSPASDHLSF 2 4.4 0.99102 -0.19581 0 0 0 7.85481 0 0 7.58323 0 0 0 0 12.0643 0 0 0 A0A8I3MZP0 A0A8I3MZP0_CANLF Prealbumin-like fold domain-containing protein LOC489992 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] carbohydrate binding [GO:0030246] ALLLLLLLLLSGAGPAR;CWKNKSLEVEVLE;ESLVYLCYA;KADGSFRLENI;LEFYQDGNGPENVG;LLLLLLLL;LLLLLLLLL;LLLLLLLLLSGAGPARGS;PGAVAALLLLLL;QTGYMLRCSLS;TIKSSIDSEPALVLG;VSGKVSCLD 12 9 1.0029 -1.3391 10.6876 0 0 9.47344 0 3.56548 0 11.286 0 0 0 0 9.4477 7.17103 0 A0A8I3MZP1 A0A8I3MZP1_CANLF Oncoprotein induced transcript 3 OIT3 Canis lupus familiaris (Dog) (Canis familiaris) renal system process [GO:0003014] calcium ion binding [GO:0005509] CFHVYCGHFYDICDEDCHGSCVDTS;ENECEQNNGGCSEIC;GSCVDTSECTCS;QSQMLTGGPISI;SYRCECGV 5 11.9 0.99521 -0.15861 9.50124 4.97471 0 0 0 0 0 6.58256 8.2009 0 11.0295 6.35039 6.72819 4.70077 5.59753 A0A8I3MZP3 A0A8I3MZP3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] VGSVGRFIL 1 6.9 1.0044 -0.80421 0 0 0 0 0 0 0 0 8.99308 0 0 0 0 0 0 A0A8I3MZQ0 A0A8I3MZQ0_CANLF Protein phosphatase 1 regulatory subunit 3A PPP1R3A Canis lupus familiaris (Dog) (Canis familiaris) DEKNTFAI;EESLQVITGNQRAA;ELELMINQCLIRSTASRDEKN;KVEFCIRYE;LNKKSERRAKKMET;MEREETISMYNPGKTHD;NKKSERRAKKMETKG;SSEDLYLE;VCSHEDKEDLE;YVRMSLDDWQTHYDIL 10 10.7 1.0033 -2.143 10.7596 0 0 0 0 7.40182 0 0 10.5499 8.85418 0 0 0 0 2.84046 A0A8I3MZQ5 A0A8I3MZQ5_CANLF Formin like 1 FMNL1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of cell morphogenesis [GO:0022604] actin binding [GO:0003779]; small GTPase binding [GO:0031267] EYFQKEDSNIDFM;ITRFEQEQRPMEEL;IVSQKDDVHVCIMCLRAI;LEERFNRVLNCMN;MEYFQKEDSNI;NHIGYDMESTDNGV;NLGADRICQAIEMYDLQAL;SLQRGLELTQ;SPGSDLLP 9 10.1 1.0032 -2.2601 0 0 0 9.43588 0 8.11411 0 10.6486 6.17055 0 0 11.411 0 0 10.6783 A0A8I3MZQ6 A0A8I3MZQ6_CANLF Neuron-specific calcium-binding protein hippocalcin HPCA Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020] calcium ion binding [GO:0005509] SELELQEWYK 1 5.2 0.87678 0.1401 0 0 0 0 0 0 10.2932 0 0 0 0 0 0 0 9.93483 A0A8I3MZR6 A0A8I3MZR6_CANLF Rab-GAP TBC domain-containing protein TBC1D2B Canis lupus familiaris (Dog) (Canis familiaris) ALFKYKEEEILKLQD;GVTGSGFP;SQQEELEQLKKDLSSQ 3 4.7 0.98678 -0.38412 0 0 0 0 0 0 0 0 11.6463 0 0 0 0 10.1851 0 A0A8I3MZS2 A0A8I3MZS2_CANLF Catsper channel auxiliary subunit epsilon CATSPERE Canis lupus familiaris (Dog) (Canis familiaris) CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] DTEQWVYQDFA;ELLWNANEP;FLKFVKIITTKKLKNLL;IFSTRSTIKLE;IPSPSGYLVAAISSL;NYSFCNLTTVFA;YLRNQTSKNLRVKYNWK 7 10.1 0.99181 -0.20849 0 0 0 0 0 0 0 0 0 0 0 0 8.60844 0 0 A0A8I3MZS8 A0A8I3MZS8_CANLF Zinc finger protein 879 ZNF879 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ESVTFRDVAVLFSHDEWLH;VLFSHDEWLHLDSAQRTLYREVM 2 5.8 0.98548 -0.23248 0 0 0 0 0 6.01004 0 0 0 0 0 0 0 0 10.8272 A0A8I3MZV1 A0A8I3MZV1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] RQKQQIYDI 1 7.3 1.0044 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 9.00675 0 0 A0A8I3MZV3 A0A8I3MZV3_CANLF Tripartite motif containing 14 TRIM14 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897] cytoplasm [GO:0005737] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] YWEVDVQEAG 1 2.2 0.99004 -0.26377 0 0 0 0 0 0 0 0 0 0 11.0603 0 0 0 0 A0A8I3MZY5 A0A8I3MZY5_CANLF Olfactory receptor OR10AG65 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LQWLLFGLFLVIYIII 1 5 0.96232 0.049233 0 0 0 0 0 5.72432 0 0 0 0 0 0 0 0 0 A0A8I3MZZ4 A0A8I3MZZ4_CANLF Solute carrier family 22 member 9 SLC22A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] DVEKEPRQP;GALGRFQI 2 3.1 1.0022 -1.4224 8.44684 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N006 A0A8I3N006_CANLF Tripartite motif containing 7 TRIM7 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DEAVQEAKELLES;EVTQKRNE;FSLPGASPGERALAEAAWA;LEELSREVTQKRN;LRAFLVEQ;SQIQETSQKPDLEFLQ;VSLKTFVLKGLLKKFKEDL 7 17.3 0.95045 0.049772 0 0 0 0 0 0 0 0 0 0 0 0 9.28829 0 0 A0A8I3N009 A0A8I3N009_CANLF Retinol dehydrogenase 13 RDH13 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" AQRSHLPLSMPSD;IIEEEEQVHILVNN 2 7.6 0.98991 -0.22225 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.9318 A0A8I3N014 A0A8I3N014_CANLF Zinc finger protein 618 ZNF618 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] PVPPYQHEEIIGKVCEL;RDSGDLVHHWVQ;SPPAVVEEKWKPQA;SQNSSEPYTCGACGIQ;VRSRYSGT 5 7.6 0.95578 0.049233 6.35189 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N033 A0A8I3N033_CANLF DNA 5'-3' helicase (EC 5.6.2.3) ERCC2 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; positive regulation of mitotic recombination [GO:0045951]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] "ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]" EGVQVAKYFLRQMAQ;NVDGLLVYFPYDYI;QDGAETSV;YIYPEQFSYMLEL 4 7 1.0033 -1.5609 0 0 0 0 12.8122 0 9.86254 0 0 0 10.167 5.15745 0 0 0 A0A8I3N044 A0A8I3N044_CANLF ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cilium [GO:0005929]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] DTPVFNEYISLVEKYIEE 1 10.3 0.97487 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 8.35036 0 0 A0A8I3N045 A0A8I3N045_CANLF Trophinin associated protein LOC119881581 Canis lupus familiaris (Dog) (Canis familiaris) PGHGGPPS;PSLPEGEH;RPQTQFTPI;SRTLNAPEHNA 4 5.7 1.0036 -2.3827 8.95765 0 0 0 0 0 0 0 0 0 5.07451 0 9.67479 8.68018 0 A0A8I3N048 A0A8I3N048_CANLF Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma PIP5K1C Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] AHVCFFRKRKKKKK;LQSYRFIKKL;RMRRMHPPQ 3 4.7 1.0023 -1.0182 0 0 9.80628 0 0 0 0 0 0 0 9.64697 10.8148 0 9.90001 3.35924 A0A8I3N051 A0A8I3N051_CANLF Tyrosine-protein kinase (EC 2.7.10.2) ABL2 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154]; regulation of apoptotic process [GO:0042981]; regulation of cellular component organization [GO:0051128]; signaling [GO:0023052] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] GGGGGGSG;GLQQPQPR;GWVPSNYITPVNSLEKHSWY;LPRGATALPLRTPSGDPAI;LVGENHVVKVA;SKLELSLQE;VAGVAAAP;VGVAGVAA;YEGRVYHYRINTTTDGKVYVT 9 9.1 1.0034 -1.6866 0 10.3106 12.4009 0 0 0 0 10.7224 10.1951 13.1831 0 0 9.45002 7.49913 0 A0A8I3N055 A0A8I3N055_CANLF HMG box domain-containing protein HMG20B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] KKRGWPKGKKRKKI;KKRGWPKGKKRKKILPN;LERRSSREVRESFFGGEN 3 5.2 0.85271 0.15531 0 0 0 0 0 0 4.42566 11.3849 0 0 0 0 0 0 7.51759 A0A8I3N068 A0A8I3N068_CANLF Olfactory receptor family 10 subfamily AG member 67 OR10AG67 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PLNYPLIM;VNLWTQDRSI 2 5.8 1.0014 -0.64146 9.5652 0 0 0 0 0 0 10.1711 0 0 8.66128 0 0 0 0 A0A8I3N076 A0A8I3N076_CANLF Protein inhibitor of activated STAT 4 PIAS4 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of macromolecule metabolic process [GO:0060255] nucleus [GO:0005634] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DSEIATTGVRVS;EEDEEDEDEEGP;EEEEDEEDEEDEDEEG;GGGGGGGA;QPGIKAVQVVL;SEEEEEDEEDEEDEDEEGP;SSEEEEEDEEDEEDED;SSEEEEEDEEDEEDEDEEG;SSSSEEEEEDEEDEEDEDE;SSSSSEEEEEDEEDEEDEDEE;TLDSSSSSEEEEEDEEDEED 11 11.1 0.99129 -0.14661 8.57939 7.77268 0 0 0 0 0 5.1157 6.39069 0 8.56365 3.61035 4.41839 6.52558 0 A0A8I3N081 A0A8I3N081_CANLF Guanine nucleotide-binding protein subunit gamma LOC119863873 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] heterotrimeric G-protein complex [GO:0005834] G-protein beta-subunit binding [GO:0031681] LQQYCMQNACKDA 1 19.1 0.94042 0.059723 0 0 0 10.684 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N082 A0A8I3N082_CANLF NAD(+) hydrolase SARM1 (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (Sterile alpha and TIR motif-containing protein 1) SARM1 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; NAD catabolic process [GO:0019677]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; nervous system process [GO:0050877]; protein localization to mitochondrion [GO:0070585]; regulation of dendrite morphogenesis [GO:0048814]; regulation of neuron apoptotic process [GO:0043523]; response to axon injury [GO:0048678]; response to glucose [GO:0009749]; signal transduction [GO:0007165] cell surface [GO:0009986]; dendrite [GO:0030425]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; protein-containing complex [GO:0032991]; synapse [GO:0045202] "NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling adaptor activity [GO:0035591]" TDPALLRHCALALGN;WSHEYQEATIEKI 2 3.9 0.91832 0.11355 0 8.03886 0 0 0 0 0 0 0 9.7139 0 0 0 0 0 A0A8I3N093 A0A8I3N093_CANLF Atos homolog protein B ATOSB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GAFQGGLL;GHSPEHTPPG;LSPPSASPVPT 3 5.4 0.98604 -0.43298 7.36431 11.2127 0 0 0 0 0 0 0 0 0 0 7.3127 0 0 A0A8I3N096 A0A8I3N096_CANLF "116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP-specific protein, 116 kDa)" EFTUD2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" cytosol [GO:0005829]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; U5 snRNA binding [GO:0030623] DEMDDDDDDD;DEMDDDDDDDD;DEMDDDDDDDDVGDH;DTDLYDEF;EPQPAPHLAREF;GENYTLEDEEDS;KVLGENYTLEDEEDSQICTVGRLW;LDEMDDDDDDDDV;LDEMDDDDDDDDVGDHDEDHPGME;MDDDDDDDD;RKVNKSYPSLTTKVE;SEIDIKVAD;VGDHDEDHPGMEVV 13 9.7 1.0017 -2.6277 6.83933 6.92327 3.40926 9.12244 0 0 9.96953 0 0 10.1886 3.73151 0 13.4558 10.3124 0 A0A8I3N097 A0A8I3N097_CANLF "5,6-dihydroxyindole-2-carboxylic acid oxidase (Tyrosinase-related protein 1)" TYRP1 Canis lupus familiaris (Dog) (Canis familiaris) melanin biosynthetic process [GO:0042438] melanosome membrane [GO:0033162] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] HHYPHDGRDDREVWPTRFFN;HYADDYEKMQNPNQ;QYQHYADDYEKMQNPN;VGLFDTPPFYSN;YFVWTHYYSVKKTFLGPG 5 12.5 1.0023 -0.65868 0 0 0 10.0729 0 0 0 0 9.05886 0 0 9.24325 0 9.45282 8.99212 A0A8I3N0A0 A0A8I3N0A0_CANLF Endothelin-converting enzyme 1 (EC 3.4.24.71) ECE1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] NLVRKTSSFLD;NTIFYPVEINES;QNWIKKNGAEQTLPTLGL;SLSEGEVYPNGLQV;TENNLGFA;VSNSKEFSEHFHC 6 10.1 0.97947 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 8.4266 0 A0A8I3N0A9 A0A8I3N0A9_CANLF TLE family member 7 TLE7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] QWVLQTPDRSELQASWLS;VPRRSWKVGRLRHGKKV 2 8.1 0.9899 -0.21499 0 0 0 0 0 0 0 0 0 0 0 0 0 7.73098 0 A0A8I3N0B0 A0A8I3N0B0_CANLF Aly/REF export factor ALYREF Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] RNA binding [GO:0003723] AQSVNRGGMTRNRGSGGFG;GVSDADIQELFAEFG 2 12.9 0.99221 -0.17856 0 0 0 0 0 8.24298 0 0 0 8.8519 0 0 0 0 0 A0A8I3N0B2 A0A8I3N0B2_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP3CB Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-mediated signaling [GO:0097720] calcineurin complex [GO:0005955]; cytoplasm [GO:0005737] calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872] EVFDMDGI;TEYFTFKQECKIKY 2 4.3 0.98574 -0.25824 0 9.12521 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N0C1 A0A8I3N0C1_CANLF Zinc finger protein 79 ZNF79 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] PSPDPALAQEETIEDEG 1 3.4 0.98495 -0.23888 0 0 0 0 0 12.2106 0 0 0 0 0 0 0 0 0 A0A8I3N0E1 A0A8I3N0E1_CANLF TBC1 domain family member 9B TBC1D9B Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] IELCKTLYNMFSEDPMEQDL;LDNVVNKQSVSPPI;PYRILHQTQDSQVYWTVAC;SEEALQQEEQ;TAVRRDPSLPYLEQYRIDA;TVALPPGG;WTVACGSSRKEITKHWEWL 7 7.6 0.98198 -0.24929 0 12.2136 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N0E9 A0A8I3N0E9_CANLF Alanyl-tRNA synthetase domain containing 1 AARSD1 Canis lupus familiaris (Dog) (Canis familiaris) alanyl-tRNA aminoacylation [GO:0006419] cytoplasm [GO:0005737] alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] EVELAQVEHYAEL;HVLIEDHRIVFS;VEQVRGRGLPDDHA 3 6.2 0.97376 0.038859 0 0 0 0 0 0 0 12.4642 10.9151 0 0 0 0 0 0 A0A8I3N0F1 A0A8I3N0F1_CANLF DnaJ heat shock protein family (Hsp40) member A4 DNAJA4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of gene expression [GO:0010628]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] GVTKKLALQKNVI;SGAKVIREKKIIEVHVEK;VLSDPKKRDIYDQGG 3 10.8 0.8677 0.17926 0 6.76514 0 9.41473 12.2525 0 0 13.1858 13.1511 0 9.78414 0 6.24654 0 0 A0A8I3N0G1 A0A8I3N0G1_CANLF rRNA N6-adenosine-methyltransferase ZCCHC4 (Zinc finger CCHC domain-containing protein 4) ZCCHC4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730] nucleic acid binding [GO:0003676]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; zinc ion binding [GO:0008270] DFRYSQFYMEDSFCHYNMFNHHFFD;EDSFCHYNMFNHHFF;IDFRYSQFYM 3 5.1 0.98926 -0.52205 0 5.04614 0 0 1.11337 0 0 0 0 0 9.30595 0 0 0 7.08183 A0A8I3N0G4 A0A8I3N0G4_CANLF 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) ALDH1L2 Canis lupus familiaris (Dog) (Canis familiaris) 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; fatty acid beta-oxidation [GO:0006635]; folic acid metabolic process [GO:0046655]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "formyltetrahydrofolate dehydrogenase activity [GO:0016155]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AGTVFVNTYNKTD;DLGEEALNEYLK;GVKQSGFGKDLGEE;NEDVYMATKF;RWRVKGKTI 5 5.7 0.98614 -0.42587 0 0 9.10643 9.58729 9.78519 9.74194 0 0 0 9.18683 0 0 0 0 0 A0A8I3N0I4 A0A8I3N0I4_CANLF Gap junction protein GJB7 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] TEKTIFILFLVITSCLSI;WMFFRDLLTGVNKY 2 13.3 0.92095 0.10908 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2458 A0A8I3N0K3 A0A8I3N0K3_CANLF Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) HMGCS2 Canis lupus familiaris (Dog) (Canis familiaris) "acetyl-CoA metabolic process [GO:0006084]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; sterol biosynthetic process [GO:0016126]" mitochondrion [GO:0005739] hydroxymethylglutaryl-CoA synthase activity [GO:0004421] IMDQREQFYHKVNFSP;IVDGKLSIQCYL;LSASSDTQTSLYKELE 3 9.4 0.98509 -0.43803 11.2857 0 0 0 6.05133 0 11.2665 0 0 0 0 0 0 0 0 A0A8I3N0K4 A0A8I3N0K4_CANLF Mab-21 like 2 MAB21L2 Canis lupus familiaris (Dog) (Canis familiaris) camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; embryonic body morphogenesis [GO:0010172]; positive regulation of cell population proliferation [GO:0008284] cytoplasm [GO:0005737]; nucleus [GO:0005634] DAWVLQFGEAENR;LMGGCRNKCLSV;SAAKQTWRLAREI;YYTERCQARKAAIAKTIREVCK 4 16.7 0.99096 0.0019646 0 0 11.4336 0 0 0 10.3968 6.25017 0 0 0 10.0591 0 0 0 A0A8I3N0K8 A0A8I3N0K8_CANLF Acyl-CoA binding domain containing 3 ACBD3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] fatty-acyl-CoA binding [GO:0000062]; protein kinase A regulatory subunit binding [GO:0034237] EVGFFDVLGNDRRREW;GSYLFWEFATD 2 5.1 0.99172 -0.18307 0 0 7.57841 0 0 5.48845 0 0 0 8.66672 0 0 0 0 0 A0A8I3N0L1 A0A8I3N0L1_CANLF Tetratricopeptide repeat protein 36 TTC36 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system neuron development [GO:0021954]; memory [GO:0007613]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein polyubiquitination [GO:1902915]; tyrosine metabolic process [GO:0006570]; visual learning [GO:0008542] ARRLQGDVAGALEDLER 1 9 0.98929 -0.21599 0 0 0 0 0 0 0 0 0 0 0 0 0 9.46134 0 A0A8I3N0L5 A0A8I3N0L5_CANLF "Calcium uptake protein 1, mitochondrial" MICU1 Canis lupus familiaris (Dog) (Canis familiaris) calcium import into the mitochondrion [GO:0036444]; calcium ion import [GO:0070509]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein homooligomerization [GO:0051260]; regulation of cellular hyperosmotic salinity response [GO:1900069] mitochondrial intermembrane space [GO:0005758]; uniplex complex [GO:1990246] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982] DGEVDMEEFEQV;ELSDHVCDVVFALFDC;FDLNGDGEVDMEEFEQ;IKRFDGKDFWQTEKIAQEREKFAD;KNINDVDT 5 13.4 0.97112 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 9.03656 0 0 A0A8I3N0M4 A0A8I3N0M4_CANLF Large ribosomal subunit protein eL39 (60S ribosomal protein L39) LOC119870509 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] NRPIPQWIQMKTGN 1 27.5 0.94489 0.061157 0 0 0 0 0 6.99379 0 0 0 0 0 0 0 0 0 A0A8I3N0M9 A0A8I3N0M9_CANLF exodeoxyribonuclease III (EC 3.1.11.2) TREX1 Canis lupus familiaris (Dog) (Canis familiaris) 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] FLDLEATGLPSS;ITGLSTAVL;LLPDCYLAQRQAPIMG 3 10.9 0.98519 -0.43078 0 0 0 0 9.38698 0 0 0 0 8.72898 8.24265 0 0 0 0 A0A8I3N0P0 A0A8I3N0P0_CANLF Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) PTF1A Canis lupus familiaris (Dog) (Canis familiaris) amacrine cell differentiation [GO:0035881]; cerebellum development [GO:0021549]; neuron fate commitment [GO:0048663]; pancreas development [GO:0031016]; regulation of neural retina development [GO:0061074]; retina layer formation [GO:0010842]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" PSPYFDDEDFF;RRVRSEAELQQL 2 7 0.98893 -0.20298 0 0 0 0 0 0 0 0 0 0 6.9939 0 0 0 12.6994 A0A8I3N0P5 A0A8I3N0P5_CANLF Opsin 5 OPN5 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to UV-A [GO:0071492]; entrainment of circadian clock by photoperiod [GO:0043153]; hyaloid vascular plexus regression [GO:1990384]; phototransduction, UV [GO:0007604]; visual perception [GO:0007601]" cytoplasm [GO:0005737]; plasma membrane [GO:0005886] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020] SSKEVAHFD;SWEADLVAG 2 4.7 1.0037 -1.1064 0 0 0 0 0 0 0 0 9.69331 0 0 0 0 0 3.73898 A0A8I3N0R3 A0A8I3N0R3_CANLF "Anterior gradient 2, protein disulphide isomerase family member" AGR2 Canis lupus familiaris (Dog) (Canis familiaris) digestive tract morphogenesis [GO:0048546]; inflammatory response [GO:0006954]; lung goblet cell differentiation [GO:0060480]; mucus secretion [GO:0070254]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of developmental growth [GO:0048639]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of gene expression [GO:0010628]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; positive regulation of protein localization to plasma membrane [GO:1903078] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615] dystroglycan binding [GO:0002162]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802] NLVYETTDKHLSP;VDPSLTVRADITGRYSN 2 17.1 0.98213 -0.24971 7.90123 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N0R5 A0A8I3N0R5_CANLF Septin SEPTIN10 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] EAERELQAKFE;KAELQKFKIKLMSELVS;KFKIKLMSELVSNGVQIYQFPTD;NLRKDKDRKKISNVQVL;VNRSIQQGFCFNILCVGETGIGK 5 16.4 0.99361 -0.069982 0 0 0 0 0 0 0 7.03353 9.05251 0 3.65203 0 9.61607 7.05094 0 A0A8I3N0S8 A0A8I3N0S8_CANLF ADAM metallopeptidase domain 19 ADAM19 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CDCGEEEECNNPCCNASNCTLREGA;DCGEEEECNNPCCNAS;ECDCGEEEECNNPC;EDGEECDCGEEEEC;EDGEECDCGEEEECNN;EDGEECDCGEEEECNNP;EECDCGEEEECN;GAECAHGA;GEECDCGEEEECNNPCCNASN;GEECDCGEEEECNNPCCNASNC;GRRCGNGYLEDGEECDCGEEEEC;GYLEDGEECDCGEEEECNN;LEDGEECDCGEEEECNNPCC;SHDSAECCSASAADGG;VAATMAHEMG;VQSSGIPM 16 8.8 1.0033 -2.2155 0 0 7.17582 0 8.20633 7.16209 0 11.0478 6.77939 0 2.91192 5.70692 8.29549 6.60586 0 A0A8I3N0T0 A0A8I3N0T0_CANLF NCK associated protein 5 NCKAP5 Canis lupus familiaris (Dog) (Canis familiaris) DYLPPPSSAKP;EEKVMLCIQENV;FVYDTDSHDDAD;PLERKLYPSVQP;SRPKTFSFIKQQRVVKR;THEKGLKTRLPVGLKVLMKSP;TSEQLPEWGSE;VGLKVLMKSPQLLRKSST;VPGAPPPL 9 5.3 0.99018 -0.26592 0 0 0 0 0 0 6.60837 0 0 0 0 0 0 0 0 A0A8I3N0U0 A0A8I3N0U0_CANLF Hemogen HEMGN Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] EALSPIMCQET;ILKGPPASPEHVRGQRP;PDQGMAEIESLF;PGVTQPPPPSL 4 4.6 0.9455 0.079321 6.68229 0 9.40882 0 0 0 0 0 0 6.61837 0 0 0 4.3131 0 A0A8I3N0U3 A0A8I3N0U3_CANLF CCN family member 3 (Cellular communication network factor 3) CCN3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; gap junction [GO:0005921] growth factor activity [GO:0008083] GTCTCHSNCP;QSGETFQPSCKYQCACRD;SCKYQCACRDGQI 3 8.8 0.98716 -0.50257 0 0 0 0 0 0 0 0 12.0457 0 0 0 0 10.214 0 A0A8I3N0W1 A0A8I3N0W1_CANLF Coiled-coil domain containing 138 CCDC138 Canis lupus familiaris (Dog) (Canis familiaris) QEFAEELQK;RSSLNFLL;SEESGMDG;VPLNAQVYELLTVF 4 6.7 1.0025 -1.7662 0 11.4746 0 0 0 0 0 5.452 0 0 0 10.0189 0 0 0 A0A8I3N0W8 A0A8I3N0W8_CANLF Translationally-controlled tumor protein TPT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] ESTVITGVDIVMNHHLQ 1 9.9 0.54098 0.43761 0 0 0 12.8664 12.0204 0 0 0 0 0 0 0 0 0 0 A0A8I3N0X1 A0A8I3N0X1_CANLF Dephospho-CoA kinase domain-containing protein DCAKD Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140] EAFGTEVLLENGDI;KDKVLMARHVLDNS;KVLMARHVLDNS 3 12.1 0.997 -0.59406 10.006 0 0 9.75687 0 0 0 0 10.8061 0 0 0 0 0 0 A0A8I3N0X3 A0A8I3N0X3_CANLF Zinc finger protein 839 ZNF839 Canis lupus familiaris (Dog) (Canis familiaris) AVGEAMAF;EDASQQKRA;LRRVLEQVTKAQPPA;PSEKANGSRS 4 4.7 1.0031 -1.7303 0 7.40948 9.03804 0 0 0 11.769 0 0 0 0 0 10.0672 0 10.2876 A0A8I3N0Y3 A0A8I3N0Y3_CANLF Retinol dehydrogenase 16 RDH16 Canis lupus familiaris (Dog) (Canis familiaris) steroid metabolic process [GO:0008202] intracellular membrane-bounded organelle [GO:0043231] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]" HQDRSSWRPPSG;NVTNPEKISRGFQET 2 9.9 0.99474 -0.15732 0 0 0 0 0 0 0 10.7561 0 0 0 0 0 0 8.51219 A0A8I3N0Y8 A0A8I3N0Y8_CANLF "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial (EC 2.3.1.181)" LIPT2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of oxygen metabolic process [GO:2000376] mitochondrion [GO:0005739] lipoyl(octanoyl) transferase activity [GO:0033819] LALQERWLRRLQA 1 5.6 0.99045 -0.26197 0 0 0 0 0 0 0 0 0 0 0 0 9.67839 0 0 A0A8I3N0Z4 A0A8I3N0Z4_CANLF Exocyst complex component 3 like 2 EXOC3L2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; in utero embryonic development [GO:0001701] exocyst [GO:0000145] ALVRETLAG;LELSEGGALPPP;PGPGAGAG;QELQPYFNKL;VLADLLFQE 5 5.7 1.0032 -1.6182 0 0 0 0 0 0 0 0 8.22424 0 8.46544 0 0 0 0 A0A8I3N109 A0A8I3N109_CANLF Serpin family B member 2 SERPINB2 Canis lupus familiaris (Dog) (Canis familiaris) cornified envelope [GO:0001533]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GATLSGRTGHGGPQFVADHPF;SNTNDLFL;SNTNDLFLSQVF;TIAMVYLGARG;WKTPFEKK 5 12.5 1.0027 -1.3506 0 5.4593 0 10.2347 0 0 11.9342 12.2536 0 0 0 0 6.68482 0 0 A0A8I3N117 A0A8I3N117_CANLF Carboxypeptidase E (EC 3.4.17.10) (Carboxypeptidase H) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) CPE Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] transport vesicle membrane [GO:0030658] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] LALCGALAACGWLL;NSLVRYLE;PEESLRSYW;QGNPIANATISVEGIDH;QNTKLAPE;VIHWIMDIPFVL 6 14.3 0.98372 0.046227 10.0699 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N120 A0A8I3N120_CANLF Zinc finger protein 396 ZNF396 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837] CPETFRQRFRQFGYQ;LEELEKEL;YRRTCEQDGKFE 3 11.2 1.0024 -1.3592 0 0 0 0 7.69251 0 8.49121 0 0 0 0 0 0 0 0 A0A8I3N124 A0A8I3N124_CANLF "EGF-like module containing, mucin-like, hormone receptor-like sequence 4" EMR4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] EMEVNIWTE;SLHLQLSICLFLAHLLF;TESTDVTHSMTQM;VGLSLSLLCLL;VLHYLYLAA;YEGTSKGTSSSGNIQ 6 12.1 1.004 -0.83331 0 0 8.69864 0 0 0 0 0 0 13.2745 0 0 8.81583 0 10.0759 A0A8I3N127 A0A8I3N127_CANLF Uncharacterized protein LOC106559183 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]" NLTHHQRIHTGEKPYECK 1 3.8 0.98471 -0.25884 0 0 0 0 0 0 0 0 0 0 0 0 0 9.01569 0 A0A8I3N128 A0A8I3N128_CANLF Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) CDK2 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterochromatin formation [GO:0031453]; post-translational protein modification [GO:0043687]; potassium ion transport [GO:0006813]; Ras protein signal transduction [GO:0007265]; regulation of G2/M transition of mitotic cell cycle [GO:0010389] "Cajal body [GO:0015030]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; endosome [GO:0005768]; male germ cell nucleus [GO:0001673]; nuclear envelope [GO:0005635]; transcription regulator complex [GO:0005667]; X chromosome [GO:0000805]; Y chromosome [GO:0000806]" ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904] GCIFAEMHLVCTQHHARCC 1 5.5 0.9504 0.049892 0 0 0 0 0 0 10.3769 0 0 0 0 0 0 0 0 A0A8I3N130 A0A8I3N130_CANLF G protein-coupled receptor 182 GPR182 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LVCAYLGAFAACWLP;STQHSIVITKEGTQPTAA;VLSLPVWMLEVA 3 11.7 0.98793 -0.46541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9568 A0A8I3N136 A0A8I3N136_CANLF Tumor protein p53-inducible protein 11 (p53-induced gene 11 protein) TP53I11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGGEDDDGEVHRSK 1 21.9 0.98429 -0.24712 0 0 0 0 0 0 0 0 0 0 0 12.9415 0 0 0 A0A8I3N141 A0A8I3N141_CANLF Cilia and flagella associated protein 70 CFAP70 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cilium movement [GO:0003341] axoneme [GO:0005930]; sperm flagellum [GO:0036126] EQLKHAVVKIVREKYLK;TNGSSATA 2 2.2 1.0035 -1.0582 6.67016 0 0 6.72547 0 0 0 0 0 0 0 0 0 0 7.82241 A0A8I3N142 A0A8I3N142_CANLF Mediator of RNA polymerase II transcription subunit 31 MED31 Canis lupus familiaris (Dog) (Canis familiaris) limb development [GO:0060173]; negative regulation of fibroblast proliferation [GO:0048147]; regulation of transcription by RNA polymerase II [GO:0006357] core mediator complex [GO:0070847]; mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] LVNAQCAKFID;QALAEQQQQN 2 16 1.0025 -0.84147 0 0 0 8.6585 0 0 0 0 0 0 0 0 0 0 10.5921 A0A8I3N149 A0A8I3N149_CANLF Rap guanine nucleotide exchange factor like 1 RAPGEFL1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] SPHHLQTKAYVRQFQVIDNQN;VHELEFVDYVFH 2 6.5 0.9767 0.047759 0 0 0 0 0 0 0 6.94427 0 0 0 0 0 0 0 A0A8I3N153 A0A8I3N153_CANLF Transitional endoplasmic reticulum ATPase (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) VCP Canis lupus familiaris (Dog) (Canis familiaris) "aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; flavin adenine dinucleotide catabolic process [GO:0072389]; mitotic spindle disassembly [GO:0051228]; NADH metabolic process [GO:0006734]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; retrograde protein transport, ER to cytosol [GO:0030970]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; viral genome replication [GO:0019079]" ATPase complex [GO:1904949]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; site of double-strand break [GO:0035861]; synapse [GO:0045202]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730] ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; MHC class I protein binding [GO:0042288]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified protein reader activity [GO:0140036]; ubiquitin-specific protease binding [GO:1990381] GADSKGDD 1 1 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4718 A0A8I3N158 A0A8I3N158_CANLF Olfactory receptor OR2D3G Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIIVLVHVDSRLHTPM;LVSYWNIISTV 2 8.7 0.96142 0.049233 0 5.24527 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N159 A0A8I3N159_CANLF Uncharacterized protein ZNF790 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECKESNQIFNDHPYFPEQ;LSQKHVTFERELP;LTYEKMSTFNH;VLQDETRGPCPDMQS 4 9 0.99675 -0.10078 0 3.45167 0 0 8.64303 7.94246 0 0 0 7.95913 0 0 0 0 5.69705 A0A8I3N164 A0A8I3N164_CANLF WD repeat domain 74 WDR74 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] nucleolus [GO:0005730] DEPQEAKKAPPEDTET;ENDKEASSDPLLELSVG;VGPGVCRMRQDP 3 11.8 0.84979 0.14915 0 6.43097 0 0 0 0 4.72934 0 0 0 0 0 0 0 6.19959 A0A8I3N165 A0A8I3N165_CANLF 26S proteasome non-ATPase regulatory subunit 8 PSMD8 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome regulatory particle, lid subcomplex [GO:0008541]" EIGAQWSI;QYLMEGSYN 2 4.8 1.0028 -0.7785 0 0 0 0 0 0 0 0 0 0 0 0 0 14.1376 0 A0A8I3N172 A0A8I3N172_CANLF Zinc finger protein 300 LOC482280 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] CGTCGKAFSEKS;VISKLEQGEELENPQ 2 4.8 0.98921 -0.30388 0 0 0 0 0 9.74194 0 0 0 0 0 0 0 13.0738 0 A0A8I3N181 A0A8I3N181_CANLF Interleukin-17 receptor C/E N-terminal domain-containing protein IL17REL Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] interleukin-17 receptor activity [GO:0030368] AEGRVSTQQVGW;DTEALWDAVHY;NIFNSFCRQAP 3 6.2 0.98527 -0.4471 0 0 0 0 0 0 0 0 0 0 0 0 10.0513 0 0 A0A8I3N182 A0A8I3N182_CANLF Uncharacterized protein LOC482707 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] NWVNKNPERLHT;PAARTRHLP;TTSYSENIGAL 3 5.3 1.0035 -0.80421 0 0 0 0 0 0 0 0 7.77307 0 0 0 0 0 0 A0A8I3N191 A0A8I3N191_CANLF Olfactory receptor LOC483514 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVDFCYSSVIAPNMLVNFWVENPVI 1 8 0.99139 -0.29352 0 0 0 0 0 0 0 13.2293 0 0 0 0 0 0 0 A0A8I3N198 A0A8I3N198_CANLF Anaphase-promoting complex subunit 11 ANAPC11 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979] anaphase-promoting complex [GO:0005680]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] cullin family protein binding [GO:0097602]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270] CPDCKVPGD 1 10.7 0.99182 -0.2705 0 0 0 10.6538 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1B0 A0A8I3N1B0_CANLF RNA-binding protein NOB1 NOB1 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit biogenesis [GO:0042274]; visual perception [GO:0007601] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521] ISGFHLPS;PYELRFKEPC;VTEFSKKTGDYPS 3 7.5 0.99615 -0.57117 0 11.1013 0 0 0 9.48257 0 10.74 0 0 0 0 11.2626 0 9.70663 A0A8I3N1B4 A0A8I3N1B4_CANLF Uncharacterized protein LOC111089966 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response to antigenic stimulus [GO:0002437]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] DLINHEIVHSGEDSLSVGNVG;LSVGNVGKPSEYSP;QCSRSFGQL 3 5.3 0.98721 -0.40623 0 0 0 8.75849 0 0 0 0 0 0 0 9.31384 0 10.2365 0 A0A8I3N1B5 A0A8I3N1B5_CANLF Casein kinase 1 alpha 1 CSNK1A1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] VGGKYKLVR;VGIPHIRSP 2 20.2 0.98654 -0.38628 0 0 0 9.12552 0 0 0 0 0 0 0 0 0 0 12.8686 A0A8I3N1C1 A0A8I3N1C1_CANLF Serine protease 54 PRSS54 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] FNNLIQPICFLSRKL;LSSFYHLE 2 7.7 0.98588 -0.43349 6.85137 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1C2 A0A8I3N1C2_CANLF Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) Canis lupus familiaris (Dog) (Canis familiaris) nuclear membrane [GO:0031965] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LLQSTPLIY 1 4.5 1.0042 -0.80421 0 0 0 0 0 0 0 0 10.8829 0 0 3.50348 0 0 0 A0A8I3N1C4 A0A8I3N1C4_CANLF Transcription factor E2F7 E2F7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DFSSSGSGY;EPSLLQYLYVQ;LVDQRQQTEPWTP;QTEPWTPTAN 4 4.2 0.98774 -0.49755 0 8.67267 0 0 0 0 0 0 9.1692 8.32238 0 0 5.72958 9.24484 8.62454 A0A8I3N1D0 A0A8I3N1D0_CANLF Ubiquitin like 4B UBL4B Canis lupus familiaris (Dog) (Canis familiaris) RGRLISKLAHRTHLH;VHLHSYPFLKLQ 2 14.7 0.93788 0.10433 14.9861 15.218 15.1419 13.9921 14.3686 14.5067 15.4207 15.5083 15.6648 0 0 11.7129 0 0 0 A0A8I3N1D8 A0A8I3N1D8_CANLF Caveolae associated protein 3 CAVIN3 Canis lupus familiaris (Dog) (Canis familiaris) caveola [GO:0005901]; protein-containing complex [GO:0032991] PRAQPAAA 1 2.1 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 8.28951 0 0 0 0 A0A8I3N1D9 A0A8I3N1D9_CANLF Origin recognition complex subunit 3 ORC3 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270]; glial cell proliferation [GO:0014009]; neural precursor cell proliferation [GO:0061351]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785]; nuclear body [GO:0016604]; nuclear origin of replication recognition complex [GO:0005664] DNA binding [GO:0003677] ELMTILQK;FQNLDEVKEEE;LGSTAKRIEEFLA;QLMMDCCVDEE 4 5.6 1.0022 -0.97154 0 0 7.30332 0 0 0 0 0 0 0 7.71706 0 0 0 0 A0A8I3N1F4 A0A8I3N1F4_CANLF Stonin-1 STON1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; focal adhesion assembly [GO:0048041]; focal adhesion disassembly [GO:0120181]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; regulation of endocytosis [GO:0030100]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929] cell leading edge [GO:0031252]; cell projection [GO:0042995]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737] cargo adaptor activity [GO:0140312] FEQSRIIKFVPLDA;FYFSPGPP;FYFSPGPPSNSPLSTP;IDQMLKLG;QKRNERYFEKDPE;RLRRLRALPS;SSPDHPHCLSYKLEL;SVAGKIHTVKIEHVSYTE 8 11.2 1.0034 -1.6898 0 0 0 7.58225 0 6.50034 11.6072 0 0 0 5.59595 0 0 0 4.62527 A0A8I3N1F7 A0A8I3N1F7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;DGFPGEFYQTFKEETKAIGKI 2 3.9 0.97773 0.047716 0 0 0 0 9.50849 0 7.28974 0 0 0 0 0 0 0 0 A0A8I3N1G0 A0A8I3N1G0_CANLF Ral transcription factor IIA subunit 1 like GTF2A1L Canis lupus familiaris (Dog) (Canis familiaris) cognition [GO:0050890]; transcription initiation at RNA polymerase II promoter [GO:0006367] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; transcription factor TFIIA complex [GO:0005672] APPANEREIMSEALLS;KNKWKFYLKD;SMTQNLNGRPFS;VIEDVIEGVRDLFAEEGI 4 11.8 0.98653 -0.45717 6.71149 0 0 0 0 0 0 0 9.61043 8.20887 0 0 0 0 0 A0A8I3N1G7 A0A8I3N1G7_CANLF Engulfment and cell motility 3 ELMO3 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; phagocytosis [GO:0006909] SH3 domain binding [GO:0017124] CGCCGIPP;SLSHSERYALQ 2 2.2 1.0039 -1.0689 10.3484 0 0 0 0 0 0 10.2269 10.6715 0 0 0 10.8522 0 7.79941 A0A8I3N1G9 A0A8I3N1G9_CANLF Uncharacterized protein LOC102156813 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LDDHMERNQEN 1 6.2 0.98049 0.035491 0 0 0 6.95152 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1I0 A0A8I3N1I0_CANLF Serine-threonine kinase receptor-associated protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translational initiation [GO:0002183] "eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]" RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] NSAALSPNYDHVVL;NVKEHSQQINDI;RDMTMFVTASKDNTAKLF 3 26.2 0.95209 0.05044 0 0 0 0 0 0 7.26172 0 0 0 0 0 0 0 0 A0A8I3N1I3 A0A8I3N1I3_CANLF Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) PRPS1L1 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide biosynthetic process [GO:0009165] magnesium ion binding [GO:0000287] HQDLSQEIAH 1 3.7 0.989 -0.26517 0 0 0 9.6655 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1J1 A0A8I3N1J1_CANLF "Prolyl 4-hydroxylase subunit alpha-1 (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] NPITGDLETV;YFEYIMAKEKDAN 2 4.3 1.0026 -0.89599 0 0 0 0 0 0 0 0 7.68068 0 0 0 0 0 0 A0A8I3N1K3 A0A8I3N1K3_CANLF Nuclear factor related to kappaB binding protein NFRKB Canis lupus familiaris (Dog) (Canis familiaris) Ino80 complex [GO:0031011] AASTPISI;AVLKKKVKEKEEKKKKKIKLIKS;EQERYRYSQPHKAFTFRMHGFESVV;GVMPPKAGQTITVATHA;KEKEEKKKKKIKLIKSE;KKKIKLIKSE;LAVLKKKVKEKEEKKKKKIK;NPEVVKYRQLCFKSQY;SSADGIPPLSQ;VISQPMKGKSVVT 10 9.5 1.0034 -2.2221 0 5.53587 13.724 0 4.11095 0 11.741 8.55148 11.7225 0 9.4944 0 0 0 0 A0A8I3N1K5 A0A8I3N1K5_CANLF Cytoplasmic protein NCK2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; vesicle membrane [GO:0012506] phosphotyrosine residue binding [GO:0001784]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; signaling adaptor activity [GO:0035591] GVEGDFLIRDSESSPSDFSV 1 5.3 0.97395 0.048296 0 0 0 0 0 0 0 0 0 0 0 0 0 9.4061 0 A0A8I3N1L5 A0A8I3N1L5_CANLF Proton-coupled folate transporter (Solute carrier family 46 member 1) SLC46A1 Canis lupus familiaris (Dog) (Canis familiaris) folate import across plasma membrane [GO:1904447] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008] folic acid binding [GO:0005542]; folic acid:proton symporter activity [GO:0140211]; heme transmembrane transporter activity [GO:0015232]; methotrexate transmembrane transporter activity [GO:0015350] LSLVTTPIIRAKLSKL;MKEVETLTSHWT;MVVFAFATITPLMFTGY;PATLNFMK;TTQYLWHRFSAEL;VLQGPLTTQYLWH 6 15.7 1.0024 -1.8477 9.89363 10.2647 0 0 0 0 0 8.99047 8.51333 0 0 0 0 0 0 A0A8I3N1P7 A0A8I3N1P7_CANLF Olfactory receptor OR5J1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVGNLGMVFL;NFFVERET;VLVIGSCVGGLI;YIQPSSQY 4 12.2 1.0045 -2.0139 0 0 0 0 0 11.7486 0 11.4791 0 0 6.39744 0 0 0 0 A0A8I3N1Q0 A0A8I3N1Q0_CANLF PCNA-interacting partner (PARP-1 binding protein) (PARP1-binding protein) PARPBP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair via homologous recombination [GO:2000042] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] LARKIIYSYLN;QVQLLARKIIYSYLNLLV 2 9.8 0.97561 0.048313 0 0 0 7.13011 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1R3 A0A8I3N1R3_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EEARFLQEADKD 1 5.1 0.95357 0.05044 0 0 0 0 0 0 0 0 0 0 0 9.234 0 0 0 A0A8I3N1R8 A0A8I3N1R8_CANLF CCCTC-binding factor CTCF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ESETFIKG;HTGERPFQCS;KCPDCDMAFVTSGELVRHR;PDAEPVEGEEEEA;SENAEPDLDDNEDEE 5 9 1.0017 -0.71145 0 13.2478 13.2916 0 13.9001 13.9361 0 14.6288 0 13.5666 13.9269 14.5477 0 13.5015 0 A0A8I3N1S2 A0A8I3N1S2_CANLF Transmembrane protein 106A TMEM106A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SSVPHLLLAP 1 4.7 0.99964 -0.61146 0 0 0 0 4.30925 0 0 0 0 0 0 0 0 0 0 A0A8I3N1T2 A0A8I3N1T2_CANLF Recombination signal binding protein for immunoglobulin kappa J region RBPJ Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; aortic valve development [GO:0003176]; arterial endothelial cell fate commitment [GO:0060844]; atrioventricular canal development [GO:0036302]; auditory receptor cell fate commitment [GO:0009912]; B cell differentiation [GO:0030183]; blood vessel endothelial cell fate specification [GO:0097101]; blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell myoblast differentiation [GO:0060379]; club cell differentiation [GO:0060486]; defense response to bacterium [GO:0042742]; dorsal aorta morphogenesis [GO:0035912]; endocardium morphogenesis [GO:0003160]; epidermal cell fate specification [GO:0009957]; epithelial cell proliferation [GO:0050673]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; hair follicle maturation [GO:0048820]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; keratinocyte differentiation [GO:0030216]; labyrinthine layer blood vessel development [GO:0060716]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ossification [GO:0030279]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; pituitary gland development [GO:0021983]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERBB signaling pathway [GO:1901186]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription of Notch receptor target [GO:0007221]; pulmonary valve development [GO:0003177]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of generation of precursor metabolites and energy [GO:0043467]; regulation of reproductive process [GO:2000241]; regulation of timing of cell differentiation [GO:0048505]; sebaceous gland development [GO:0048733]; secondary heart field specification [GO:0003139]; somatic stem cell population maintenance [GO:0035019]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" DIGVFLSKRIKVISKPSKK;FLSKRIKVI;GGGGGGGE;GGGGGGGG;IGVFLSKRIKVISKPSKKKQSL;KKKEQMERDGCSEQESQPCA;LTFTYTPE;SLTFTYTPEPGPRPHCSAAGAI 8 13.8 1.003 -1.5182 5.36503 0 0 0 11.1605 0 0 0 0 8.35491 6.19596 0 0 6.72792 0 A0A8I3N1T9 A0A8I3N1T9_CANLF furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) FURIN Canis lupus familiaris (Dog) (Canis familiaris) blastocyst formation [GO:0001825]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of viral entry into host cell [GO:0046598]; regulation of cholesterol transport [GO:0032374]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058]; zymogen activation [GO:0031638] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867] GVKVYTMDR;HGTRCAGEVAAVANNGVCGVG;YQEPTDPKFPQQ 3 5.3 1.0015 -0.70398 10.3097 0 10.5434 0 0 0 8.4876 0 0 8.8363 8.70376 0 0 0 0 A0A8I3N1U0 A0A8I3N1U0_CANLF Olfactory receptor family 56 subfamily B member 2C OR56B2C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LILIIIKQ;VGMESGIFVCMAI;VISITHSATMTLPLIPVLLNVL;VLILHSVLK 4 16.3 0.99207 -0.27195 0 0 0 0 0 0 0 0 0 9.32069 0 0 0 0 0 A0A8I3N1U5 A0A8I3N1U5_CANLF HAT C-terminal dimerisation domain-containing protein ZBED10P Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] ELSDHWVSAYRLMEWLVEHRRPLQE;LATEDNLEFVD;RGSSRSLL;SPASTLAL;SPDQSEVGQPSKSKK;VSDCSLPPSPSPHSPKTMCMG 6 8.2 1.0032 -2.3375 0 6.11164 0 6.04566 6.80967 0 0 0 0 11.2173 0 6.59917 0 10.2144 11.7564 A0A8I3N1U8 A0A8I3N1U8_CANLF Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) PEF1 Canis lupus familiaris (Dog) (Canis familiaris) COPII vesicle coating [GO:0048208]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592] COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] PGGLYGGA 1 2.8 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 7.11842 0 0 0 0 A0A8I3N1V1 A0A8I3N1V1_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD1 Canis lupus familiaris (Dog) (Canis familiaris) protein K63-linked deubiquitination [GO:0070536] cysteine-type deubiquitinase activity [GO:0004843] HYDAVFDHSYPNPEY;IWLSWLSNG;PASAAAGPPAGSCKP;SPTVSTMIHYLGPE;YDNWCRQT 5 12.1 1.0026 -1.7761 13.1387 0 0 7.36291 10.1993 0 8.0031 8.35601 0 7.80193 0 0 11.2731 8.85991 0 A0A8I3N1V8 A0A8I3N1V8_CANLF Uncharacterized protein MRLN Canis lupus familiaris (Dog) (Canis familiaris) VGRLLKIL;VGRLLKILFV;VGRLLKILFVIFV 3 28.3 1.0035 -1.0646 0 8.58244 0 0 0 6.26245 0 0 0 0 4.00054 0 0 0 0 A0A8I3N1W7 A0A8I3N1W7_CANLF WASP like actin nucleation promoting factor WASL Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041]; dendritic spine morphogenesis [GO:0060997]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex localization [GO:0031503]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653] actin cap [GO:0030478]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634] actin binding [GO:0003779] KKKGKAKKKRLTK;SIYCCCCC 2 4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 5.7301 0 0 0 0 0 A0A8I3N1Y2 A0A8I3N1Y2_CANLF Mitogen-activated protein kinase 12 MAPK12 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] MRYTQTVDIWSAGCIMAEMITG;TAAEALTHPYFESL;VTAAEALTHPYFESLQ 3 10.6 0.8512 0.15731 0 0 0 8.02081 9.18507 0 0 0 0 0 0 0 9.45851 0 0 A0A8I3N1Y4 A0A8I3N1Y4_CANLF Uncharacterized protein ZCCHC17 Canis lupus familiaris (Dog) (Canis familiaris) RNA stabilization [GO:0043489] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AAKKKKKK;AAKKKKKKKKHKKKH;AKKKKKKKKHKKK;KAAKKKKKKKK;KDSKAAKKKKKKKKHKKK;KKKKKKKK;LDPNNVIIEQEERRRRSFQDY;TSKDSKAAKKKKKKKKHKKKH;TSKDSKAAKKKKKKKKHKKKHK 9 24 1.0022 -0.76561 0 8.82934 0 8.25767 0 0 0 0 5.89191 0 6.15253 0 0 4.36814 5.87103 A0A8I3N1Z2 A0A8I3N1Z2_CANLF EF-hand domain-containing protein KCNIP3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] nucleus [GO:0005634]; voltage-gated potassium channel complex [GO:0008076] "calcium ion binding [GO:0005509]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; potassium channel regulator activity [GO:0015459]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGG;RRLWPASAARAALRAAAA 2 4.7 0.98919 -0.22677 7.8993 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N1Z8 A0A8I3N1Z8_CANLF Transmembrane protein 184A TMEM184A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ARVHLCPHSSPCPPSPLQ;FATRELLQPFEPV;SCFYGTCCLQGMS;TQQATHETPSPGTH;VYAEKKENS 5 14.1 1.002 -0.65594 0 0 0 0 0 10.3145 0 0 0 9.5674 0 0 0 7.91013 0 A0A8I3N213 A0A8I3N213_CANLF "RELB proto-oncogene, NF-kB subunit" RELB Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cytokine [GO:0034097] cytoplasm [GO:0005737] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDLEIVEP;SRASWEGRADFSQADVHRQIAI;TSELRICRI 3 6.8 1.0011 -0.9478 10.3602 0 0 0 0 0 0 0 9.36558 0 0 0 0 0 0 A0A8I3N214 A0A8I3N214_CANLF "Myb-like, SWIRM and MPN domain-containing protein 1" MYSM1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallopeptidase activity [GO:0008237] DESHEEEE;GRRWTKIAKLI;HEEEELKPP;LKPPEQEVEIDRNTIQEE;PSDLRGRADP;RTRRRRVRDPWGN;YLSKNSLPEKFW 7 9.2 1.0029 -2.193 0 0 0 9.18649 9.18696 9.41884 0 5.10396 0 11.2359 10.9412 11.3395 11.5168 0 0 A0A8I3N218 A0A8I3N218_CANLF Exonuclease 5 EXO5 Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]" DLSDSEFLEYLDLE;ELPGFLAPEKAAVLD;FEEQEVKSKVQHYMAYWMG;GASIHLARELEV 4 16 1.003 -0.7874 6.86802 0 0 0 10.6858 0 0 0 0 0 0 0 0 0 0 A0A8I3N222 A0A8I3N222_CANLF SEL1L adaptor subunit of ERAD E3 ubiquitin ligase SEL1L Canis lupus familiaris (Dog) (Canis familiaris) "protein secretion [GO:0009306]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" Derlin-1 retrotranslocation complex [GO:0036513]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839] ALTAIEGTAHGEPCHFP;IRETNLHERSEVLCC;IVGENETYPRALLHWNRAASQGY 3 6.4 0.98625 -0.45417 0 0 0 9.97943 0 0 0 0 0 0 0 9.2908 0 0 10.0768 A0A8I3N225 A0A8I3N225_CANLF Kelch domain containing 2 KLHDC2 Canis lupus familiaris (Dog) (Canis familiaris) FLFGGFTTDKQPLNYGIQ;FVFGGRYRDARMNDLHYLNLDTW 2 13.4 0.9764 0.048313 0 0 0 0 6.72124 0 0 0 0 0 0 0 0 0 0 A0A8I3N229 A0A8I3N229_CANLF F-box and WD repeat domain containing 7 FBXW7 Canis lupus familiaris (Dog) (Canis familiaris) DLKSAKEPLPHQTVMKI;IVSGSDDNTLKVWSAV;MMQVIEPQFQRD 3 7.6 0.97463 0.04706 7.83479 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N230 A0A8I3N230_CANLF Transmembrane protein 127 TMEM127 Canis lupus familiaris (Dog) (Canis familiaris) endosome organization [GO:0007032]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007] early endosome [GO:0005769]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] ELLSEMEENEPYPAEY;PGALSITALCTALA 2 12.6 0.924 0.11545 0 0 0 0 0 0 0 8.69073 0 0 0 0 0 5.58289 0 A0A8I3N239 A0A8I3N239_CANLF Exostosin glycosyltransferase 2 ACCS Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] LNQNTLRIK;LWPKIRVPLKVVRT;VIKVTPRKKFKC 3 5.2 1.0017 -0.69301 0 0 0 3.25586 0 0 7.7239 0 0 6.83023 0 0 0 0 0 A0A8I3N245 A0A8I3N245_CANLF Uncharacterized protein AREG Canis lupus familiaris (Dog) (Canis familiaris) growth factor activity [GO:0008083] LEAVTCQCHQDYFGE 1 5.9 0.95249 0.053887 0 0 0 0 0 5.06725 0 0 0 0 0 0 0 0 0 A0A8I3N256 A0A8I3N256_CANLF Caspase recruitment domain family member 9 CARD9 Canis lupus familiaris (Dog) (Canis familiaris) antifungal innate immune response [GO:0061760]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; host-mediated regulation of intestinal microbiota composition [GO:0048874]; immunoglobulin mediated immune response [GO:0016064]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of tumor necrosis factor production [GO:0032760]; protein homooligomerization [GO:0051260]; regulation of apoptotic process [GO:0042981]; regulation of interleukin-2 production [GO:0032663]; response to exogenous dsRNA [GO:0043330]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494]; response to xenobiotic stimulus [GO:0009410]; stress-activated MAPK cascade [GO:0051403] CBM complex [GO:0032449]; cytoplasm [GO:0005737] CARD domain binding [GO:0050700]; protein homodimerization activity [GO:0042803] IRKRKVGVLLDILQRTGH;LVIRKRKVGVLLDILQRTGHK;MIIDASGESGLTQLLMSE;QLLSSKDDLIKELRVKD 4 10.4 0.9968 -0.11254 5.85317 0 0 0 0 0 5.74276 0 0 0 0 9.79479 0 0 0 A0A8I3N257 A0A8I3N257_CANLF Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) SLC30A3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transport [GO:0051050]; zinc ion import into lysosome [GO:0140916]; zinc ion import into synaptic vesicle [GO:0099180] glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; microvesicle [GO:1990742]; synaptic vesicle membrane [GO:0030672] antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385] DVGSMIGSLFSL;GFSSCTLQVEQYQ;PSPATGGSETTRL;VPGVRATHELHLWS 4 13.4 0.9924 -0.18057 0 9.82521 9.94115 0 8.46442 0 0 0 0 9.87026 0 8.36247 0 0 0 A0A8I3N258 A0A8I3N258_CANLF Epstein-Barr virus induced 3 EBI3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] QWEPPRSWPFPELFSLKYWIRYKHH 1 11.1 0.9792 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.40657 A0A8I3N259 A0A8I3N259_CANLF General transcription factor IIIC subunit 2 GTF3C2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995] VSFFTGGPLW 1 1.1 0.99847 -0.61146 0 9.21028 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N280 A0A8I3N280_CANLF NADP-dependent oxidoreductase domain-containing protein LOC119874631 Canis lupus familiaris (Dog) (Canis familiaris) bile acid biosynthetic process [GO:0006699] Delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; lyase activity [GO:0016829] AEILFSNDMTCEDDDKTP 1 4.5 0.97975 0.048313 9.10682 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N281 A0A8I3N281_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) ACVR2A Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363] activin receptor complex [GO:0048179] activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] AAPRTRRPLGQRG;CAAACAAVP;ERSTWLRGRENLRKKKRERRKKERK;LRKKKRERRKKERKRCKERKRQPR;QEVVVHKKKRPVLR;VLRDYWQKHAGMAML;WLRGRENLRKKKRERRKKERKR 7 10.9 1.0024 -0.76227 0 7.1636 0 0 0 0 0 10.682 0 6.6416 0 0 0 7.15522 9.93603 A0A8I3N285 A0A8I3N285_CANLF Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor Sec12) PREB Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; regulation of COPII vesicle coating [GO:0003400] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AAGGGGAA;RSVPVWLLLLL;VTVGWDLKASVWQKDQL;VWQKDQLVTQLH 4 11.4 0.99384 -0.1703 0 3.50906 0 0 0 8.96295 0 0 0 0 0 0 0 0 11.4643 A0A8I3N286 A0A8I3N286_CANLF PHD finger protein 12 PHF12 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] Sin3-type complex [GO:0070822] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] CHHTIRYLFVCEQLFPL;PLTPPAAGGLQNHT;RYLFVCEQLFP;VGAHPLAS 4 4.6 1.0031 -1.5055 0 0 11.8448 0 0 0 0 0 0 0 5.97214 8.00781 0 0 14.9257 A0A8I3N292 A0A8I3N292_CANLF KIAA1549 KIAA1549 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; photoreceptor connecting cilium [GO:0032391] ASGPPPAG;EASRRVPNKIQLIAM;EFPVVDDLSS;ETTSYSGLSPVAR;GVVIPVLVVMVIVIIL;IPSTAPLV;LLLLLLLL;LPGLWLRRRLLLLLL;LPGLWLRRRLLLLLLLLARPA;LSASSLVP;LVVMVIVIILYWKLCRTDKL;LWLRRRLLLLLLLLAR;LWLRRRLLLLLLLLARP;PGLLLPGLWLRRRLLLLL;QRAAIILG;RLLLLLLL;RLLLLLLLL;RRLLLLLLLLA;RRRLLLLLLLL;TRPCPSGGHLATPASPT;VEPSLVPEREPG;VGSLFTPTDSP 22 8.3 0.98407 -0.24721 0 0 0 0 0 0 0 0 0 0 0 0 9.86149 0 0 A0A8I3N2A1 A0A8I3N2A1_CANLF Sequestosome 1 SQSTM1 Canis lupus familiaris (Dog) (Canis familiaris) aggrephagy [GO:0035973]; brown fat cell proliferation [GO:0070342]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; mitophagy [GO:0000423]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-membrane-bounded organelle assembly [GO:0140694]; pexophagy [GO:0000425]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein complex stability [GO:0061635]; response to mitochondrial depolarisation [GO:0098780]; temperature homeostasis [GO:0001659]; transcription by RNA polymerase II [GO:0006366] aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sperm midpiece [GO:0097225] identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular condensate scaffold activity [GO:0140693]; protein kinase C binding [GO:0005080]; protein sequestering activity [GO:0140311]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified protein reader activity [GO:0140036]; zinc ion binding [GO:0008270] EEQMESDNCSGGDED;KNYDIGAALDTIQ;MEAEAAAG;SLLLTSTLQ 4 9.7 1.0021 -1.2434 0 0 0 0 5.9524 0 5.32539 0 0 0 0 0 0 10.4947 0 A0A8I3N2A2 A0A8I3N2A2_CANLF Olfactory receptor OR52E7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLLLGIPGLEIAQIWLG;GVARLACA;LHQPMFYFLAMLS 3 11.8 0.97926 0.046227 8.8089 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N2B1 A0A8I3N2B1_CANLF "Beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)" LFNG Canis lupus familiaris (Dog) (Canis familiaris) compartment pattern specification [GO:0007386]; marginal zone B cell differentiation [GO:0002315]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; ovarian follicle development [GO:0001541]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of somitogenesis [GO:0014807]; somitogenesis [GO:0001756]; T cell differentiation [GO:0030217] Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity [GO:0033829] LSEYFGLLSRARRDAGPPPGGA;SRHKEMTFIFT 2 8.6 0.94397 0.083907 0 0 9.73594 0 0 6.6084 0 0 0 0 0 0 0 0 0 A0A8I3N2B2 A0A8I3N2B2_CANLF CEA cell adhesion molecule 19 CEACAM19 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IPEYPQKDQDLLLSVQGIPGNFQDF;LPTFFFFFFKIL 2 12.4 0.98399 -0.24452 0 0 0 0 0 6.83895 0 0 0 0 0 0 12.8194 0 0 A0A8I3N2B9 A0A8I3N2B9_CANLF Uncharacterized protein ZNF786 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] PPSQPSGERSVCGGEGEGA;SLPQCQRRFPC 2 3.8 0.98795 -0.49527 0 9.17871 0 0 0 0 12.0622 0 0 0 0 0 0 0 0 A0A8I3N2D6 A0A8I3N2D6_CANLF B box-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DHTVRQKEEVSPGNKLALI;EKSNQVCTSCEDNA 2 10.8 0.9868 -0.23175 0 0 0 0 0 0 0 0 0 0 0 0 0 9.94411 0 A0A8I3N2E4 A0A8I3N2E4_CANLF Centromere protein C CENPC Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382] kinetochore [GO:0000776]; nucleus [GO:0005634] centromeric DNA binding [GO:0019237] CLDDEERKKKFMVNL;LLSSFRAQSKVPKVPNSSKQ;QDCFEEKSFANDF;TTPFKERKITTSGSSGAQEFLN 4 8.1 1.0016 -0.69558 0 0 0 8.83042 0 0 10.2219 0 11.6237 0 0 0 0 0 0 A0A8I3N2F2 A0A8I3N2F2_CANLF Dimethylglycine dehydrogenase DMGDH Canis lupus familiaris (Dog) (Canis familiaris) VGVSLAYHLAKAGM 1 1.8 0.94228 0.061073 0 0 0 0 0 0 0 0 10.7276 10.4038 10.3993 0 0 0 0 A0A8I3N2F7 A0A8I3N2F7_CANLF Flotillin FLOT1 Canis lupus familiaris (Dog) (Canis familiaris) "axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; plasma membrane raft assembly [GO:0044854]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein kinase C signaling [GO:0070528]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]" adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cell-cell contact zone [GO:0044291]; centriolar satellite [GO:0034451]; COP9 signalosome [GO:0008180]; cortical actin cytoskeleton [GO:0030864]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; flotillin complex [GO:0016600]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; sarcolemma [GO:0042383]; uropod [GO:0001931] protease binding [GO:0002020] GVSISQRQGR;VEEIYKDRQKFS 2 5.1 0.98626 -0.42032 9.62565 0 0 0 0 0 0 0 8.8798 0 0 0 0 0 0 A0A8I3N2G1 A0A8I3N2G1_CANLF Protein phosphatase 1G PPM1G Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] AEEEEEDSEECSEEED;AEEEEEDSEECSEEEDG;AENEEDEDDTEEA;DEAEEEEEDSEECSEEEDGY;EAEEEEEDSEEC;EAENEEDEDDTEEAEEDEEEEE;EEEEDSEECSEEEDGY;EEEEDSEECSEEEDGYSSEEA;EKVADEDDVDNEE;ENEEDEDDTEEAEEDEEEEEMM;EQMISALPD;GDGTGCDNMTC;GEAGPSCS;GTEAGQGGEPGTPTGE;MTIEELLT;RNKNLPPEEQMIS;SEDESDEAEEEEEDSEECSEEED;SEEAENEEDEDDTE;SEECSEEEDGYSSEEAENEEDED;SEEEDGYSSEEAENEEDED;VLTLTDDHEFMVI 21 25 0.99893 -2.93 9.37241 7.63016 4.4363 4.78785 7.64508 9.01561 0 8.94348 9.75077 0 0 0 0 0 7.5404 A0A8I3N2J3 A0A8I3N2J3_CANLF Palmitoyl-protein thioesterase 1 Canis lupus familiaris (Dog) (Canis familiaris) PGSGTARVPWHVDPATP 1 23.3 0.98352 0.046227 0 0 0 0 7.68032 0 0 0 0 0 0 0 0 0 0 A0A8I3N2J8 A0A8I3N2J8_CANLF Uncharacterized protein ZNF45 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ENFRNLLSVGHQ;FLSPEKSHRKE 2 3.3 0.98537 -0.4409 0 0 0 11.1766 0 0 0 9.06711 0 0 0 0 0 0 0 A0A8I3N2K2 A0A8I3N2K2_CANLF Olfactory receptor OR13F1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AMGSTECVLLSM 1 3.8 0.94472 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.09339 A0A8I3N2K3 A0A8I3N2K3_CANLF Leukotriene B4 receptor 2 LTB4R2 Canis lupus familiaris (Dog) (Canis familiaris) keratinocyte migration [GO:0051546] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] leukotriene B4 receptor activity [GO:0001632] LLTPLFVAFL;PLAATLALHLALAD;TTALAFFS 3 8.9 1.0036 -1.0695 7.83023 0 0 0 0 0 0 10.3354 10.6087 0 0 0 0 0 0 A0A8I3N2K4 A0A8I3N2K4_CANLF Leucine rich repeats and calponin homology domain containing 1 LRCH1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to chemokine [GO:1990869]; negative regulation of T cell migration [GO:2000405] cytoplasm [GO:0005737]; membrane [GO:0016020] DLLSFCLVHILFVI;GGGGGGGG;PFCMHIFKYLSI;RNLESIDPQFT;VLRSEFITYIKDRTEDCEELLRIEE 5 10.4 0.93824 0.060874 0 0 0 0 0 7.04767 0 0 0 0 0 0 0 0 0 A0A8I3N2L2 A0A8I3N2L2_CANLF Homeobox B6 HOXB6 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; erythrocyte homeostasis [GO:0034101] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LSGAEEPPRFHPEPRKSD 1 8 0.98096 0.048313 4.66465 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N2L9 A0A8I3N2L9_CANLF Amine oxidase (EC 1.4.3.-) AOC2 Canis lupus familiaris (Dog) (Canis familiaris) amine metabolic process [GO:0009308] copper ion binding [GO:0005507]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038] DVTVERHGGPL;EDLVAWVTA;TFGHGVFSGM 3 4 1.0041 -0.82826 0 0 8.44733 0 10.3682 0 0 0 0 0 0 0 0 0 0 A0A8I3N2M5 A0A8I3N2M5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] elongin complex [GO:0070449]; VCB complex [GO:0030891] APPHAHAPSPSPRRRRRRRRRRL;RRRRRRRRRRLPL 2 8.8 0.93422 0.10581 0 0 6.97785 0 0 0 0 0 0 0 0 0 0 4.92339 0 A0A8I3N2M6 A0A8I3N2M6_CANLF Enhancer of mRNA-decapping protein 4 EDC4 Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] P-body [GO:0000932] AASALHLLSP;ASPKLKRKGKK;ENEDCCEEG;FSSISEFLLTHPVL;HEQEQRRLERALAEG;PVLLSLIQQLASDLGTRTD;PVRVSQIK 7 6.1 1.0026 -1.8524 0 0 5.67016 0 4.65667 0 10.675 0 9.41673 0 0 0 0 0 7.08396 A0A8I3N2N5 A0A8I3N2N5_CANLF DNA helicase (EC 3.6.4.12) CHD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] DKLLTRLRERGNRVLIFSQMVRM;DLMSRNTI;EERQKELEEIYMLP;EQRKKVEE;FTEFDARK;KAKLKKRKPRVKK;KKVKARRPVPRRT;KSSSKSKRSQGPV;LKLTDKAKLKKRKPRVKKENKEPR;MSALQKQYYKW;NSSSESSESQSESE;PGSGHGSESNSSSESSESQSESE;SYKEDDDFETDSDDL;TEKDESEVQYLIKWKG;TEKDESEVQYLIKWKGWSYIHST;TESKRQAQ;YKEDDDFETDSDDL 17 11 0.99817 -3.3169 0 8.04368 12.0893 0 7.12887 8.80919 7.50637 5.43303 0 2.88168 3.04252 10.6673 12.3982 8.53064 8.86366 A0A8I3N2P3 A0A8I3N2P3_CANLF Replication factor C subunit 2 RFC2 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261] DNA replication factor C complex [GO:0005663]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689] NDSMTDGAQQA 1 3.5 0.98119 0.035491 0 0 7.94597 0 0 0 0 4.04824 0 0 0 0 0 0 4.47359 A0A8I3N2P6 A0A8I3N2P6_CANLF Heterogeneous nuclear ribonucleoprotein M HNRNPM Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] IERMGSGVERMGPAIERMG;KMGGMEGPFGGGMENMGR;LVMDRMGSVERMGSG;RSFGEPLGRG;VLLREHWIQAGMQEDWAGEIL 5 10.6 0.98798 -0.31985 0 0 11.5754 0 0 0 9.33992 0 0 9.54092 0 9.25153 0 0 10.2561 A0A8I3N2Q3 A0A8I3N2Q3_CANLF phosphoserine transaminase (EC 2.6.1.52) PSAT1 Canis lupus familiaris (Dog) (Canis familiaris) L-serine biosynthetic process [GO:0006564] O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648] GFYVSVGG 1 2.5 1.0047 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 9.39223 0 A0A8I3N2Q5 A0A8I3N2Q5_CANLF Signal transducing adaptor family member 1 STAP1 Canis lupus familiaris (Dog) (Canis familiaris) signaling adaptor activity [GO:0035591] TEMLEKNPSL;TIELERPVT 2 6.5 0.98645 -0.41414 0 0 0 0 0 0 0 10.7576 0 0 0 0 0 0 0 A0A8I3N2Q9 A0A8I3N2Q9_CANLF 60S ribosomal protein L31 LOC106559504 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] TYVPVTSFKNLQ 1 9.6 0.95166 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 10.911 0 A0A8I3N2R1 A0A8I3N2R1_CANLF Par-3 family cell polarity regulator PARD3 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; endomembrane system [GO:0012505] DTGTWSKAAINDSA;LSTSISDTNFSSEE;RMKQEQESNRST;VEVQMQRQRQEER 4 4.2 0.99416 -0.11975 7.10245 0 0 0 0 0 11.419 0 0 0 0 6.96093 0 7.22207 0 A0A8I3N2R2 A0A8I3N2R2_CANLF Neutrophil cytosolic factor 4 NCF4 Canis lupus familiaris (Dog) (Canis familiaris) phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554] cytosol [GO:0005829]; endosome membrane [GO:0010008]; NADPH oxidase complex [GO:0043020] phosphatidylinositol-3-phosphate binding [GO:0032266]; superoxide-generating NADPH oxidase activator activity [GO:0016176] IWVLMDEDVRIF;RRLRPRTRKVKNESPQDAIFDRM 2 10.3 0.9329 0.096693 9.66667 0 0 0 12.7331 0 0 0 0 0 0 0 0 0 0 A0A8I3N2R4 A0A8I3N2R4_CANLF Homeobox B8 HOXB8 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; dorsal spinal cord development [GO:0021516]; embryonic skeletal system morphogenesis [GO:0048704]; grooming behavior [GO:0007625]; negative regulation of myeloid cell differentiation [GO:0045638]; sensory perception of pain [GO:0019233] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AVACHGDPGNFYG 1 5.3 0.99248 -0.19245 0 0 0 0 0 0 0 0 0 10.2103 0 0 0 0 0 A0A8I3N2T0 A0A8I3N2T0_CANLF Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) TRMU Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble position uridine thiolation [GO:0002143] mitochondrion [GO:0005739] ATP binding [GO:0005524]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049] NRVHWIAEEPPAALV 1 3.5 0.99407 -0.12708 10.5983 10.1066 0 0 0 0 10.809 10.9793 0 3.10981 0 0 0 0 0 A0A8I3N2T9 A0A8I3N2T9_CANLF Solute carrier family 22 member 31 SLC22A31 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FASFAVLA;LAEAGGEDPEDSP;LEAVATLL;PESPCWLLAT 4 12 1.0012 -0.92136 0 0 0 12.9025 0 13.1696 0 0 0 0 12.7442 0 7.25814 0 10.5671 A0A8I3N2U2 A0A8I3N2U2_CANLF E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) RNF41 Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471] erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KTSAEHKHQLAEQKR;TSAEHKHQLAEQ 2 4.7 0.98786 -0.22486 0 0 0 0 0 0 0 0 0 0 0 0 11.4057 0 0 A0A8I3N2U3 A0A8I3N2U3_CANLF Zinc finger protein 697 ZNF697 Canis lupus familiaris (Dog) (Canis familiaris) LGLGLSESESLSRSPREEE;LGLSESESLSR;QGVYEAQDSEDK;QRMHRLAEAAAAASLEPFGLAG;RRRRRRRREG 5 9.3 1.0024 -0.71539 10.1989 7.60274 9.97154 0 0 0 0 11.4775 0 0 6.53252 0 7.21364 0 0 A0A8I3N2V0 A0A8I3N2V0_CANLF Forkhead box O3 FOXO3 Canis lupus familiaris (Dog) (Canis familiaris) "antral ovarian follicle growth [GO:0001547]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cellular response to glucose starvation [GO:0042149]; cellular response to oxidative stress [GO:0034599]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glucose homeostasis [GO:0042593]; initiation of primordial ovarian follicle growth [GO:0001544]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; neuronal stem cell population maintenance [GO:0097150]; oocyte maturation [GO:0001556]; ovulation from ovarian follicle [GO:0001542]; positive regulation of autophagy [GO:0010508]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of translation [GO:0006417]; response to fatty acid [GO:0070542]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; RNA polymerase II transcription repressor complex [GO:0090571] "beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; mitochondrial transcription factor activity [GO:0034246]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAGAPSGGTQAPPQ;EEDDDDDDE 2 3.4 0.98549 -0.24601 0 0 9.23016 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N2W2 A0A8I3N2W2_CANLF H/ACA ribonucleoprotein complex non-core subunit NAF1 NAF1 Canis lupus familiaris (Dog) (Canis familiaris) box H/ACA snoRNP assembly [GO:0000493]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; pseudouridine synthesis [GO:0001522]; ribosome biogenesis [GO:0042254]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] identical protein binding [GO:0042802]; telomerase RNA binding [GO:0070034] IFGPVAHPFYVLRFNSSEH;MEVVEAAAQ;VEELTIILPEDIE 3 8.9 1.0019 -0.67654 9.93152 0 11.4475 0 0 8.53982 0 0 0 0 0 0 0 10.1041 0 A0A8I3N2W8 A0A8I3N2W8_CANLF MRN complex-interacting protein N-terminal domain-containing protein MRNIP Canis lupus familiaris (Dog) (Canis familiaris) LAVPQGGPPRPA 1 7.2 0.99127 -0.27592 0 0 8.82988 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N2Y1 A0A8I3N2Y1_CANLF Surfeit 2 SURF2 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] DEDGKPRLTPGKGPG;LVHKRGKKQLSLSKKKFK 2 12.8 0.94167 0.10221 0 0 0 0 0 0 0 0 0 0 0 8.69603 0 0 0 A0A8I3N2Y4 A0A8I3N2Y4_CANLF Cyclin-dependent kinase inhibitor domain-containing protein CDKN1A Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346]; signal transduction by p53 class mediator [GO:0072331] nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861] RGGREAPPCSPRCRRLTSEV 1 6.3 0.94906 0.0558 0 0 0 0 0 6.59334 0 0 0 0 0 0 0 0 0 A0A8I3N2Y6 A0A8I3N2Y6_CANLF Uncharacterized protein LOC100682968 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SDKSFEYKECEIDFSHSSQV;SLVDLPSRSV;YECKECGKAFTQNSQLT 3 6.8 1.0022 -0.84376 4.92681 0 0 0 0 0 0 0 6.18311 9.12954 0 0 0 0 0 A0A8I3N2Y7 A0A8I3N2Y7_CANLF glutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) GFPT2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate derivative metabolic process [GO:1901135]; cellular response to leukemia inhibitory factor [GO:1990830]; glutamine metabolic process [GO:0006541] carbohydrate derivative binding [GO:0097367]; transferase activity [GO:0016740] DLALELYTQRSLLV;ELTELPVMVELASD;IHDLALEL;KEIFETLIKG;TYMHSEGILAGE;VGAWCCASSHVSH 6 8.9 1.0033 -2.0769 0 0 0 9.29156 6.03841 0 13.6626 0 0 0 0 9.88293 0 0 0 A0A8I3N2Z8 A0A8I3N2Z8_CANLF Sp4 transcription factor SP4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] IVTSGELDSSVT;RWHTGERPFVCNWMFCGKRFTRSDE;TLTPSGQISWQ 3 6.1 0.98756 -0.50393 0 0 0 9.52691 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N300 A0A8I3N300_CANLF Dendrocyte expressed seven transmembrane protein DCSTAMP Canis lupus familiaris (Dog) (Canis familiaris) cellular response to interleukin-4 [GO:0071353]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to tumor necrosis factor [GO:0071356]; membrane fusion [GO:0061025]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of cell growth [GO:0030308]; osteoclast fusion [GO:0072675]; positive regulation of bone resorption [GO:0045780]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of monocyte differentiation [GO:0045657] cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008] DFIQHLGVCCF;PSVQERRIRYLHGKLLKKRSKQA 2 7.2 0.99141 -0.19484 0 5.81011 0 0 0 0 0 0 12.2744 0 0 0 0 0 0 A0A8I3N301 A0A8I3N301_CANLF Dual specificity phosphatase 8 DUSP8 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] AATGSAAA;LAGCPPWGPAPLLTICLS;PHHGWGPAPSEGD;VGPGSWAPPLDSP 4 7.9 1.0033 -1.5782 9.24676 0 0 0 0 0 9.91603 0 0 0 0 8.77033 8.68675 0 0 A0A8I3N302 A0A8I3N302_CANLF G protein subunit alpha transducin 2 GNAT2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; background adaptation [GO:0120302]; cell morphogenesis [GO:0000902]; cone retinal bipolar cell differentiation [GO:1904390]; detection of light stimulus involved in visual perception [GO:0050908]; dopamine metabolic process [GO:0042417]; gene expression [GO:0010467]; homeostasis of number of retina cells [GO:0048877]; L-glutamate import [GO:0051938]; neural tissue regeneration [GO:0097719]; phototransduction [GO:0007602]; protein localization [GO:0008104]; reactive gliosis [GO:0150103]; response to organic cyclic compound [GO:0014070]; response to UV [GO:0009411]; retinal cone cell development [GO:0046549]; retinal rod cell differentiation [GO:0060221]; tissue remodeling [GO:0048771]; visual behavior [GO:0007632] photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202] G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVSAEDKELAK;TDIIIKENLKDC 2 6.5 0.99353 -0.15972 8.02569 8.5868 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N304 A0A8I3N304_CANLF Actin like 9 ACTL9 Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; fertilization [GO:0009566] acrosomal vesicle [GO:0001669]; perinuclear theca [GO:0033011]; sperm head [GO:0061827] FSDPPFSP;VATRDHPLLFSDPPFSPTTNRE 2 5.3 0.98884 -0.20413 0 0 0 7.95414 0 0 0 0 0 0 8.04374 0 0 0 6.74913 A0A8I3N305 A0A8I3N305_CANLF Citrate synthase CS Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759] citrate (Si)-synthase activity [GO:0004108] AKGGEEPLPEG;YYGMTEMNYY 2 4.6 0.98507 -0.23893 0 0 0 0 0 0 0 0 10.0289 0 0 0 3.48091 0 8.29669 A0A8I3N321 A0A8I3N321_CANLF Protein FAM25A FAM25A Canis lupus familiaris (Dog) (Canis familiaris) DVTATVTEAVTGAVAHAV 1 20.2 0.94571 0.050303 0 0 0 0 0 8.97948 0 0 0 0 0 0 0 0 0 A0A8I3N336 A0A8I3N336_CANLF Target of myb1 membrane trafficking protein TOM1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] LNLIQTVFSSEVPSGQ 1 3.6 0.95934 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.06905 A0A8I3N339 A0A8I3N339_CANLF DNA replication licensing factor MCM7 (EC 3.6.4.12) MCM7 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270] MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] LDVYIEHRLMMEQRSRDPGAARSP 1 6.2 0.9932 -0.28622 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.19476 A0A8I3N342 A0A8I3N342_CANLF Anaphase promoting complex subunit 4 ANAPC4 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; regulation of mitotic metaphase/anaphase transition [GO:0030071] anaphase-promoting complex [GO:0005680] ADVIGKSMNQAICIPL;CMCEAWEEI;DIDDEWELDESS;EVTRMARKFTH;LDAAGIEDAIT;LSVVTEVSAGGASEVSYFQLETNL;PQEIIFLVWSP 7 12.5 1.0049 -1.0503 10.1834 10.8902 4.02317 0 10.3445 0 10.3012 0 0 0 0 0 9.70248 0 0 A0A8I3N346 A0A8I3N346_CANLF ERI1 exoribonuclease family member 2 ERI2 Canis lupus familiaris (Dog) (Canis familiaris) 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] LGVCLEYECKRKQLLK;SLNKVPTKKNSRILARNL;TKKLARQLGLIRRKFVAPANG 3 8.4 0.8663 0.14471 0 0 0 0 0 0 9.197 7.393 0 0 0 0 0 0 0 A0A8I3N349 A0A8I3N349_CANLF C-C motif chemokine receptor 10 CCR10 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] C-C chemokine receptor activity [GO:0016493] AARGPERRRALRVVVALVAAFVVL 1 6.6 0.97426 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.98523 A0A8I3N351 A0A8I3N351_CANLF Family with sequence similarity 187 member A FAM187A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCCYLFHCCPNFSP;GVRGEQWRIGLCYLQSPDLSPRYH 2 9.2 0.94118 0.10213 0 0 0 9.82695 0 0 8.28522 0 0 0 0 0 0 0 0 A0A8I3N356 A0A8I3N356_CANLF O-acyltransferase SOAT1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] cholesterol O-acyltransferase activity [GO:0034736] GVILCFYSQ;GVILCFYSQEWYARQHCPL;STSLDNGGCAITS 3 6.5 0.99633 -0.58486 0 5.37215 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N362 A0A8I3N362_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" EDEVVSCDFNSDTHSSTFDA 1 6.7 0.96612 0.0486 0 0 0 0 0 0 0 0 10.8352 0 0 0 0 0 0 A0A8I3N364 A0A8I3N364_CANLF Uncharacterized protein E2F4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GVPGPAAE;SELLEELMSSEV;TAALAPAAGWPGT 3 7 1.0029 -0.85819 0 8.15795 10.6178 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N368 A0A8I3N368_CANLF Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) KATNB1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of microtubule depolymerization [GO:0031117] axon [GO:0030424]; centrosome [GO:0005813]; cytosol [GO:0005829]; katanin complex [GO:0008352]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; spindle pole [GO:0000922] ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982] APPEDDMA;VKIPQQVELV 2 2.7 1.0024 -1.1506 0 16.8663 16.8054 16.8202 0 0 0 11.9624 0 0 0 0 0 16.471 16.4082 A0A8I3N372 A0A8I3N372_CANLF Probable RNA-binding protein 46 (RNA-binding motif protein 46) RBM46 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] CTYPFFPG 1 1.7 1.0047 -1.1044 0 3.12271 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N379 A0A8I3N379_CANLF Family with sequence similarity 174 member B FAM174B Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] GGGGGGGG;KKTRKYDII;PPLLLLLL;RVEMAPLNEEDDE 4 24.1 0.99541 -0.56909 0 0 0 0 0 0 0 0 10.2859 0 0 0 0 0 0 A0A8I3N380 A0A8I3N380_CANLF "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3)" MAGI3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASPRKPALRHV;DTESQRKRT;EDCEDGDM;GAERGEFPYL;MVYFIDHNTK;VLEQNGKPGHALISDRLNGPSDPSE 6 5.1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 3.44334 0 0 A0A8I3N383 A0A8I3N383_CANLF Golgi associated PDZ and coiled-coil motif containing GOPC Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] EDSASKLDDLHSL;FVDVDLLLGE;VEYEDESGHRY;VGPIRKVLLLK 4 11 0.99184 -0.54288 0 0 0 2.62639 0 0 0 0 0 0 0 0 6.37969 0 0 A0A8I3N3A3 A0A8I3N3A3_CANLF Achaete-scute family bHLH transcription factor 1 ASCL1 Canis lupus familiaris (Dog) (Canis familiaris) "adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; lung neuroendocrine cell differentiation [GO:0061100]; motor neuron migration [GO:0097475]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron differentiation [GO:0045665]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte development [GO:0014003]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of epithelial cell differentiation [GO:0030856]; regulation of mitotic cell cycle [GO:0007346]; regulation of timing of subpallium neuron differentiation [GO:0060165]; response to retinoic acid [GO:0032526]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]" neuronal cell body [GO:0043025]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" QELLDFTNW;VETLRSAVEYIRAL 2 10.6 0.9896 -0.21414 0 0 10.9474 8.51798 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N3B2 A0A8I3N3B2_CANLF Copper transport protein SLC31A1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; copper ion import [GO:0015677]; establishment of localization in cell [GO:0051649]; intracellular copper ion homeostasis [GO:0006878]; plasma membrane copper ion transport [GO:0015679]; protein complex oligomerization [GO:0051259]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; intercalated disc [GO:0014704]; late endosome membrane [GO:0031902]; lateral plasma membrane [GO:0016328]; recycling endosome membrane [GO:0055038] copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; identical protein binding [GO:0042802]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910] SHGEGMHNMMMHMTFY 1 8.5 0.95509 0.049233 0 7.25001 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N3B6 A0A8I3N3B6_CANLF Olfactory receptor LOC483568 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CMTQVFALHLFGCM;EGKKKALSTCTSHIIVVILFFGPC 2 12.3 0.94073 0.10225 0 0 0 0 10.6598 0 0 9.28489 0 0 0 0 0 0 0 A0A8I3N3B8 A0A8I3N3B8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCCYKPCCC;CCCYKPCCCESSCC;CCCYKPCCCESSCCKPCCCQ;CCKPCCSQSCCCYKP;CCSQSCCCKPCCSQSCCC;CCSQSCCCKPCCSQSCCCKPCCS;CCSQSCCCYKPCCCESSC;CCSQSCCCYKPCCCESSCCKP;CGSSCCQSSCCKPCCCESSC;CQSSCCKPCCCE;CSQSCCCYK;CVPACPCSSCGSCGG;CYKPCCCESSCCKPCCCQS;ESSCCKPCCCQSSCCKPCCCESSC;ESSCCKPCCSQSCCCYKPCCCE;GCGSSCCQSSCCKPCCCESSCCKP;GCGSSCCQSSCCKPCCCESSCCKPC;GGCGSCGGS;GGCGSSCC;KPCCCESSCCKPCCCQ;PCCCESSCCKPCC;PCCCESSCCKPCCCQ;PCCCESSCCKPCCSQSCCC;PCCCESSCCKPCCSQSCCCYK;PCCCQSSCCKPCCCE;PCCSQSCCCYKPCCCESSCC;PVCCCVPACPCSSCG;QSCCCYKPCCCE;SCCCKPCCSQSCCCK;SCCKPCCCESSCCKPCCSQSCCC;SQSSCCKPCCCESSCCKPCCSQ;SSCCKPCCCESSCC;SSCCKPCCSQSCCCKPCCSQSSCC;SSCCKPCCSQSCCCYKPCCCES 34 79.2 1.0029 -0.89405 4.74028 4.86245 10.2138 5.79766 0 0 7.4132 4.54182 11.6752 7.68349 7.60881 5.23431 9.32328 10.2846 7.8254 A0A8I3N3C4 A0A8I3N3C4_CANLF THUMP domain containing 1 THUMPD1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] RNA binding [GO:0003723] ERSESNENDLSEEK;FQIVYKSRNNSHMNREEV;VKDYMLFRKYNLQ 3 12.6 0.9905 -0.51589 0 0 0 9.86896 8.11811 0 0 0 0 0 0 0 0 0 0 A0A8I3N3C8 A0A8I3N3C8_CANLF Zinc finger protein 226 ZNF226 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] KNKLCRCKQNIDVVSWI;VLNCKVDGPNRT 2 3.8 0.93391 0.096667 0 0 0 0 0 8.23515 0 0 0 0 0 0 0 0 7.39909 A0A8I3N3F7 A0A8I3N3F7_CANLF Xaa-Arg dipeptidase PM20D2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246] nucleoplasm [GO:0005654] carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802] GRPGPPPPVKVIVLGTPAE 1 4.4 0.95399 0.049463 0 0 0 3.9814 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N3G0 A0A8I3N3G0_CANLF Uncharacterized protein LOC488909 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SNPRRLKSW 1 4.8 0.9901 -0.26166 0 0 0 0 0 9.28792 0 0 0 0 0 0 0 0 0 A0A8I3N3G1 A0A8I3N3G1_CANLF Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) NDST1 Canis lupus familiaris (Dog) (Canis familiaris) "heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]" Golgi apparatus [GO:0005794]; membrane [GO:0016020] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213] ETFEEIQFF 1 1.1 1.0043 -0.80421 0 0 0 0 0 0 0 0 10.3052 0 0 0 0 0 0 A0A8I3N3G5 A0A8I3N3G5_CANLF Myosin light chain 6B MYL6 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AAGAPPAKPKA;GAELRHVLTTLGERMTEEEVE 2 15.3 0.98501 -0.23782 0 0 0 0 0 0 6.92291 0 0 0 0 0 0 0 0 A0A8I3N3I2 A0A8I3N3I2_CANLF Peroxisome assembly protein 12 (Peroxin-12) PEX12 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein polyubiquitination [GO:0000209]" peroxisomal membrane [GO:0005778] ubiquitin ligase activator activity [GO:1990757]; zinc ion binding [GO:0008270] ETIKSLTAL;KLISSLREEDEY;SSLREEDEYSIHPP;VLFPYLKVKLEKL 4 10.3 0.9941 -0.15608 0 11.8805 0 0 0 6.6423 12.3587 12.4577 0 0 0 0 4.69025 0 12.8686 A0A8I3N3J0 A0A8I3N3J0_CANLF Capping protein regulator and myosin 1 linker 2 CARMIL2 Canis lupus familiaris (Dog) (Canis familiaris) AAPRTRKTTLGDL;AGPQGEAAVHQAED;CRKDIQDFTQATLDTTRS;ELRSAGAQVIQD;PFREEIQWDVDTIYHRQGCRHFSL;PSHQWQLRQK;SPSPRRASPSPD;YLEVQAMALQETPPQ 8 8.6 0.99118 -0.54575 6.06188 10.8225 0 8.05918 0 0 7.45105 0 0 0 0 9.69964 0 3.2421 0 A0A8I3N3K1 A0A8I3N3K1_CANLF Calcium release activated channel regulator 2B CRACR2B Canis lupus familiaris (Dog) (Canis familiaris) regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115] cytoplasm [GO:0005737] calcium ion binding [GO:0005509] CCCCCCCSW;CCCCCCCSWA;GGSPSLCLSS;GPTCCCCCCCS;GPTCCCCCCCSWA;PGPTCCCCCC;PGPTCCCCCCCS;PPGPTCCCCCCC;PTCCCCCCC 9 4.9 0.99846 -3.2817 6.80103 0 0 9.45752 8.34629 0 0 0 8.49466 5.00634 7.68419 7.61949 8.58368 7.86542 3.49403 A0A8I3N3K5 A0A8I3N3K5_CANLF [histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) EZH1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] histone H3K27 methyltransferase activity [GO:0046976] DKYMSSFLFNLNNDFVVDA;KKRKHRLWAAHCRKIQLKK;LNNDFVVDATRKGNK;PNVYKRKNKEIKIEP;SVQREQSLHSFH 5 10 0.99161 -0.13711 0 0 0 0 0 0 0 6.39055 0 0 0 9.82489 0 0 0 A0A8I3N3K7 A0A8I3N3K7_CANLF mitogen-activated protein kinase (EC 2.7.11.24) MAPK14 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] FTPARSLEEFNDVYLV;KLTDDHVQFL;LSTCWRRCLYW;NWMHYNQTVDIWSVGC 4 17.3 1.0019 -1.21 14.7656 10.1445 0 0 0 0 0 0 9.31186 0 0 10.1024 0 0 0 A0A8I3N3M4 A0A8I3N3M4_CANLF WD repeat domain 87 Canis lupus familiaris (Dog) (Canis familiaris) CFYSISVNYFVSLNW;DISMAGEPE;EEEEEEEEEEEEEESLSEEEE;EEEEEEEESLSEEEEESLSEEVEEV;EEEEPGVKEEELTWD;EEELGEEEEE;ESRLMKVIRSEE;GKKKKAIARKGIGITKRKKK;IGKKKKAIARKGIGITKRKK;IGKKKKAIARKGIGITKRKKK;KKQLKKLLRRIEKNKP;LDKLVLEKRKFKKEARKL;LQKNKVILQPINKILCACALTH;PSFFLSFERIFVPKFVYLGQGL;QAKRRQLIKKELRV;QLKKLLRRIEKNKPEKTQLK;RSQTPEALNWHLLAESQ;SEEEEELGEEEE;SLSEEEEEEEEEEEEEE;SLSEEEEESLSEEVEEV;SLSEEVEEVEEEEESLS;VEEEEHAG;VHLKVIPP;VLPSATRR;WMETMEMEGQ 25 8.9 0.99723 -3.703 13.6544 8.76364 0 5.70365 6.7486 4.52713 13.0045 4.038 11.7388 0 3.67909 0 0 6.20304 11.2166 A0A8I3N3M6 A0A8I3N3M6_CANLF Glypican 6 GPC6 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] GNDVNFQDTSDESSGSGSGSGCMDD;RMFQLINPQYHFSEDYLECVSKY 2 8.6 0.94408 0.081801 0 0 0 0 0 0 10.7478 0 0 0 5.65875 0 0 0 0 A0A8I3N3M7 A0A8I3N3M7_CANLF Cadherin 9 CDH9 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GLSTGALIAILLCVIILLV;TASVPEMSGVGTSVIQV;VIILLVLVVLFAALKRQRKKEPLI;VLVVLFAALKRQ 4 6.8 0.59223 0.38874 0 0 0 4.96915 0 0 0 0 6.94275 0 0 11.103 4.37955 0 0 A0A8I3N3P9 A0A8I3N3P9_CANLF DUF4515 domain-containing protein LOC119878757 Canis lupus familiaris (Dog) (Canis familiaris) AECDPGGC;GAGDGAAG 2 3.6 1.0038 -1.1044 0 0 0 0 0 0 0 7.22978 0 0 0 0 0 0 0 A0A8I3N3R4 A0A8I3N3R4_CANLF DNA primase large subunit PRIM2 Canis lupus familiaris (Dog) (Canis familiaris) "DNA replication, synthesis of primer [GO:0006269]" primosome complex [GO:1990077] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]" LEDEYEPRRKDHISHF 1 9.5 0.95556 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 8.53384 0 A0A8I3N3R6 A0A8I3N3R6_CANLF Chymotrypsin like CTRL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] WGTTNCNVRQPAIYTRVSKFSTWI 1 9.1 0.99395 -0.28504 0 0 0 0 0 0 0 10.209 0 0 0 0 0 0 0 A0A8I3N3R7 A0A8I3N3R7_CANLF Small ribosomal subunit protein uS17 (40S ribosomal protein S11) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] ICQDYLHYIRKYN;LSPCFRDVQIGDIVTVGE;VHLSPCFRDVQIGDI 3 20.9 0.94347 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7082 0 A0A8I3N3S6 A0A8I3N3S6_CANLF Transmembrane protein 223 TMEM223 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrial inner membrane [GO:0005743] mitochondrial ribosome binding [GO:0097177] GAPGGLCS;GLAVGCGA 2 7.9 1.0024 -1.3692 0 0 0 0 9.42639 0 0 10.8009 0 0 0 0 0 0 0 A0A8I3N3T3 A0A8I3N3T3_CANLF Cadherin 10 CDH10 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synaptic membrane adhesion [GO:0099560] glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALIAILLCIIILLVIVVLFAALKR;EVEYRIIDGDGTDMFDII;LSTGALIAILLCIIILLVIVVLF;PRFHKLAEMYGGGD;SLATYAYEGTDSL;VISDNDYPIQ 6 10.5 1.002 -0.65554 0 0 0 0 0 0 7.75302 0 0 8.9792 0 7.02791 0 8.95577 4.35339 A0A8I3N3T5 A0A8I3N3T5_CANLF FERM domain containing 4B FRMD4B Canis lupus familiaris (Dog) (Canis familiaris) establishment of epithelial cell polarity [GO:0090162] cytoskeleton [GO:0005856] AGRAGISIVVSSFGMKIQ;EAELTGKMPKEYPLNVGEKPP;QLENLYFREKKF;QSGLFVQTW;RCLGFAGLQVPC;SLSDTTTYDD;TILHFAVRFYIESISFL;VEAAKKLA;VLHCPIWT 9 11.4 1.0044 -2.0143 0 9.15469 6.9982 0 8.95134 0 0 0 0 0 10.1862 5.94626 0 9.54077 0 A0A8I3N3T7 A0A8I3N3T7_CANLF C2 domain-containing protein LOC489080 Canis lupus familiaris (Dog) (Canis familiaris) GSCRLWKKLRDAP;LLLLLLLL;PDVPFVVPPSLQDQDRGPL;SLRKQHTGGQE;SPLVKLHL 5 17.4 1.0023 -1.2452 0 0 12.5965 0 9.32492 0 7.58082 0 0 10.7996 11.0025 10.655 12.6793 12.5997 12.9827 A0A8I3N3U3 A0A8I3N3U3_CANLF RAN binding protein 10 RANBP10 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin ligase complex [GO:0000151] LAHTEMLQDAFSLLAYSDPWS;PIPAACGIYYFEVK 2 5.6 0.95578 0.050734 0 0 0 0 0 0 0 0 9.60062 0 0 0 0 0 0 A0A8I3N3U6 A0A8I3N3U6_CANLF Uncharacterized protein ISM2 Canis lupus familiaris (Dog) (Canis familiaris) EAEEDYPVEYSESED;EEEAEEDYP;GEEEEEEEEAEEDY;HAARPPNNGRACAD;LVSTDFSPELHFKVDT;PVEYSESEDQEDSDDEEEL;VEYSESED 7 15.3 1.0035 -1.6378 0 0 9.54953 0 0 0 0 0 8.45562 10.3987 0 0 0 0 5.05398 A0A8I3N3U9 A0A8I3N3U9_CANLF Small ArfGAP 1 SMAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] DKYEKKKYYDK;NPTVGFGQPPN;VPVPAPAP 3 7.2 1.0017 -1.3193 0 0 0 0 6.08194 9.2105 0 0 0 0 11.8882 0 0 0 0 A0A8I3N3W1 A0A8I3N3W1_CANLF Zinc finger protein 404 ZNF404 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QLIQHQIIH;SEKSYECKECRKGFRKYSCLTEHVR;TFSDVAIDFSQEEWE 3 8.9 1.0026 -0.71479 0 0 0 5.61029 0 0 0 5.13804 9.38325 0 0 0 0 7.45828 0 A0A8I3N3W2 A0A8I3N3W2_CANLF Testis expressed 48 TEX48 Canis lupus familiaris (Dog) (Canis familiaris) TCSLQKEELASKNP 1 11.8 0.94227 0.07627 0 0 0 0 0 0 0 7.16882 0 0 0 0 0 0 0 A0A8I3N3W5 A0A8I3N3W5_CANLF Proteasome assembly chaperone 3 PSMG3 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248] protein-containing complex [GO:0032991] molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877] KDRNAEGLKAVKEVIQ 1 13.1 0.95959 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 3.90747 0 0 A0A8I3N3X0 A0A8I3N3X0_CANLF UDP-glycosyltransferases domain-containing protein LOC119874467 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glucuronosyltransferase activity [GO:0015020] KPAKPLPKE;LDSLIEHMI 2 3.4 0.98496 -0.24656 0 0 0 0 0 0 0 10.972 0 0 0 0 0 0 0 A0A8I3N3X6 A0A8I3N3X6_CANLF F-box and WD repeat domain containing 12 FBXW12 Canis lupus familiaris (Dog) (Canis familiaris) AFKYSVDLL;AFSLLQASQVNRCWNR;CTWDVQEVGNSEGDIYTLTVPE;TTSMDDSLHLYMWEDEGRYPYLKS;VGDGNMIVFESGPYLFLF 5 22.6 0.99564 -0.086194 7.02603 9.53343 0 9.19478 7.39438 0 0 0 6.27059 0 0 0 10.3185 0 0 A0A8I3N3Y5 A0A8I3N3Y5_CANLF Coenzyme Q10A COQ10A Canis lupus familiaris (Dog) (Canis familiaris) cellular respiration [GO:0045333] ubiquinone binding [GO:0048039] YSMQEMFEVVSN 1 5 0.95221 0.05044 4.53618 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N3Z6 A0A8I3N3Z6_CANLF TraB domain containing TRABD Canis lupus familiaris (Dog) (Canis familiaris) EQPPQEADVE;SLEKLQQAVRQNGV;TDLNIQEI;WTTDLNIQEI 4 9 1.0021 -1.2802 3.95541 10.5547 8.77883 0 0 0 3.43456 0 0 0 0 0 8.52129 3.0619 0 A0A8I3N3Z9 A0A8I3N3Z9_CANLF LRRCT domain-containing protein SLITRK5 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] AGGHPHAHVH;FLEATGLDLLHL;IQDIETGAFHGLRG;LRGLRRLHLNNNKLE;PREDLLSPVQ;VIQDIETGAFHGLR 6 6.2 0.98841 -0.31912 0 6.00921 8.47058 0 0 9.63659 10.3145 12.3388 0 0 0 0 0 0 0 A0A8I3N402 A0A8I3N402_CANLF Uncharacterized protein MRPL48 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ribosome [GO:0005761] PICSAGGI 1 6.6 0.98993 -0.26384 0 11.5629 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N420 A0A8I3N420_CANLF Microtubule associated protein 9 MAP9 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281]; spindle assembly [GO:0051225] DEYEKWLEKKERQERIERKQKKRHS;KASVEDQNEELTENHN;KPSQKQNIEPEKADSIRAAVYQEWL;LIMNDLTVDPLFKS 4 12.4 0.99204 -0.17706 7.8716 0 0 0 0 0 0 0 0 0 0 0 9.68071 5.54133 0 A0A8I3N425 A0A8I3N425_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488] exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]; presynapse [GO:0098793] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905] PGLKLVKTKK;SFKVPQEELENASS;VPGLKLVKTKKTSFLR 3 19.6 0.99119 -0.0042098 0 0 0 0 0 4.67852 0 0 0 0 0 0 0 0 7.55612 A0A8I3N428 A0A8I3N428_CANLF Transporter SLC6A11 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] plasma membrane [GO:0005886] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] GIPVFFLET;TSPVMEFWE 2 3.1 0.98518 -0.25795 0 0 0 0 0 0 0 0 0 0 11.0296 0 0 0 0 A0A8I3N433 A0A8I3N433_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] LDAMMNEAPGPIDFTMFL 1 10.1 0.98857 -0.26117 0 0 0 0 0 0 0 11.0806 0 0 0 0 0 0 0 A0A8I3N440 A0A8I3N440_CANLF Olfactory receptor OR5M9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FIALVHVEVYIL 1 3.9 0.69366 0.287 11.1968 11.5928 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N445 A0A8I3N445_CANLF Elongation factor 1-gamma Canis lupus familiaris (Dog) (Canis familiaris) AFEGDDGFCVFESNAIAYYV;LSGKRRRLLPLLLRKK;LSGKRRRLLPLLLRKKWL 3 13.7 0.93522 0.097546 0 0 0 0 0 0 0 0 5.85957 6.80116 0 0 0 0 6.43703 A0A8I3N461 A0A8I3N461_CANLF Retinal G protein coupled receptor RGR Canis lupus familiaris (Dog) (Canis familiaris) phototransduction [GO:0007602]; visual perception [GO:0007601] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881] QKLKKPGHLQVPALIAKAAP 1 7.9 0.973 0.048206 0 0 0 0 0 0 0 0 0 6.71932 0 0 0 0 6.52105 A0A8I3N465 A0A8I3N465_CANLF "Protein disulfide isomerase like, testis expressed" PDILT Canis lupus familiaris (Dog) (Canis familiaris) germ cell migration [GO:0008354]; spermatid development [GO:0007286] endoplasmic reticulum [GO:0005783] protein disulfide isomerase activity [GO:0003756] KERDVFVMFY;LLVFKKGK;VFKKGKIVKREE 3 4.1 1.0016 -1.3135 9.32942 0 0 0 0 0 0 0 0 4.36001 0 4.16535 9.1683 0 0 A0A8I3N475 A0A8I3N475_CANLF Uncharacterized protein TIMELESS Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] nucleus [GO:0005634] EEEEGEEEEKEEELQ;ETLYELLQLGWEERQ;LSETLYELLQLGWEE;NLVVQNKQKKRKKKKKAV;QNKQKKRKKKKKAVGQPV;RALLLARKKKASLV;SQALRALLLARKKKASLVST 7 6.1 0.99325 -0.15159 0 11.4408 0 0 9.5275 10.1037 0 0 0 6.92267 0 2.66946 0 8.12205 0 A0A8I3N479 A0A8I3N479_CANLF Ral GEF with PH domain and SH3 binding motif 2 RALGPS2 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] ETSWPAFERNRLYHS;TFQENFVRGTI 2 4.6 0.99179 -0.20764 0 0 0 0 0 0 0 0 10.5914 0 0 0 0 0 0 A0A8I3N483 A0A8I3N483_CANLF Zinc finger E-box binding homeobox 2 ZEB2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] DTDPETLRDE;EEEEDDMREGG;EEEEDDMREGGVEHTW;FAYRTQLERHMVT;IDYTLEKVNEAKACLQS;IKYRHEKNEENFSC;LDGAQDYMSGLDDMTD;REEEEDDMREGGV;SPVKPMDSITSPSI;YRHEKNEENF 10 8.5 1.0032 -2.1086 0 0 8.73098 0 0 4.08678 0 11.2394 12.5866 8.94099 0 0 5.09145 11.6952 0 A0A8I3N484 A0A8I3N484_CANLF Forkhead box L3 FOXL3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] EEKRLTRPAYSYI;GLQDGRNPRL 2 10.4 0.99279 -0.55182 0 0 0 0 0 8.12861 0 0 0 0 0 0 0 0 0 A0A8I3N487 A0A8I3N487_CANLF Olfactory receptor OR13J1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLLVGAILLLPIP;HLHTPMYFFLGNLSILDICYTSTF 2 11.9 0.9869 -0.23144 0 0 0 0 0 0 0 7.69432 0 4.40184 0 0 0 0 0 A0A8I3N493 A0A8I3N493_CANLF Serpin family A member 4 SERPINA4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ATGIFTTFLS;EALTPEMLTRW;GITKEKKLQV 3 7.4 1.0031 -0.8812 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.49635 A0A8I3N4A0 A0A8I3N4A0_CANLF Zinc finger and BTB domain containing 3 ZBTB3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DLVCIHNEIVT;IVKVCKRRLQ;PQPSLASAETSGHW 3 6.8 0.99242 -0.55228 0 0 11.9815 0 3.73433 5.82283 0 0 0 0 0 0 6.3565 0 5.93869 A0A8I3N4A6 A0A8I3N4A6_CANLF Cerebellin 3 precursor CBLN3 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of synapse structure [GO:0099558] extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; synaptic cleft [GO:0043083] LTLGCGWAQEGAEPVLLEGECLVVC 1 12.2 0.97912 0.035538 0 0 0 0 0 0 0 0 0 7.72908 0 0 0 0 0 A0A8I3N4A7 A0A8I3N4A7_CANLF Reticulon RTN4 Canis lupus familiaris (Dog) (Canis familiaris) axonal fasciculation [GO:0007413]; blastocyst formation [GO:0001825]; cardiac epithelial to mesenchymal transition [GO:0060317]; cerebral cortex radial glia-guided migration [GO:0021801]; endoplasmic reticulum tubular network formation [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; intracellular sphingolipid homeostasis [GO:0090156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of axon extension [GO:0030517]; nuclear pore complex assembly [GO:0051292]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERBB3 signaling pathway [GO:1905580]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]; regulation of branching morphogenesis of a nerve [GO:2000172] cell projection [GO:0042995]; endoplasmic reticulum tubular network membrane [GO:0098826]; glutamatergic synapse [GO:0098978]; nuclear envelope [GO:0005635]; postsynaptic density [GO:0014069] ubiquitin protein ligase binding [GO:0031625] DEEEDEEEEDEEDEDEDLE;DETLFALPAASEP;DLEELEVLERKP;EDEEEEDEEDEDEDLEELEV;EEDEEEEDEEDEDEDLE;EEEDEEEEDEEDEDEDLE;EGGKPYLESFQPSLD;GEYTDLEVSPKNE;IVTEKNFSTKTSNPF;PEAVKDGS;VLLETAASLPSL;YLESFQPSL 12 8.7 0.98782 -0.39944 4.80488 8.93773 11.2147 8.46046 9.15848 10.2101 11.6045 11.6121 12.0179 10.2838 11.1818 5.73509 7.45869 10.5964 11.7237 A0A8I3N4B6 A0A8I3N4B6_CANLF Reticulon RTN3 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] IVYEKYKDTS;VFMWLMTYVGA;VHINRALKLIIRLFLVE 3 15.8 0.99914 -0.61146 0 0 0 7.76626 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N4D1 A0A8I3N4D1_CANLF "Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (Nucleoside diphosphate-linked moiety X motif 1)" NUDT1 Canis lupus familiaris (Dog) (Canis familiaris) DNA protection [GO:0042262] nucleus [GO:0005634] "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; metal ion binding [GO:0046872]" AGPLTCPLRSPQP;EESGLTVDTLHKVGQIMFE;GVQPHWPIVQ;INKTLKKKKKKKL;INKTLKKKKKKKLKGPP;KKKKKLKG;KTLKKKKKKKL;KTLKKKKKKKLK;KTLKKKKKKKLKGPPGRS;LAFCTGTWGRQK;LKKKKKKKLKGP;NKTLKKKKKKKLK;TLKKKKKKKLKG;TLKKKKKKKLKGP;TLKKKKKKKLKGPP 15 11.4 0.99355 -0.28364 0 0 0 0 0 0 9.1921 0 0 0 0 0 0 0 0 A0A8I3N4D8 A0A8I3N4D8_CANLF FAD dependent oxidoreductase domain containing 2 FOXRED2 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] endoplasmic reticulum lumen [GO:0005788] flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491] AAPPHRDYCVLGAGPAGLQ;DLRSFYAESCFLFALT;ESNQSADAITLPQ;IESGLLRDYATVGRPREDGG;NSIVRRVNEASG;VFFYDRSVGHTEDAW;VGHILPLRRFLEN 7 15.8 0.99272 -0.069127 10.8953 6.88521 0 7.90671 0 9.28042 0 1.96993 9.61134 0 0 0 0 0 0 A0A8I3N4E3 A0A8I3N4E3_CANLF Zinc finger BED-type containing 4 ZBED4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DKYGREEAPGGP;EAESGVIHFT;IKSQRMVQNLLSI;LSEGERASVQCFSHTV;QVIPMIHILN;SSPGKLVQESP;VLQENGGSGLPPPY 7 7.4 1.0034 -1.1101 11.4452 0 0 0 8.76225 0 12.9924 0 0 0 0 0 0 0 0 A0A8I3N4F4 A0A8I3N4F4_CANLF Colony stimulating factor 2 receptor subunit beta CSF2RB Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] cytokine receptor activity [GO:0004896] AVLSCSWEVWSEV;CPEIEDHD;GMFPVNYRHSE;NDYRSHITCRWA;PAGSGGPE;QGHWLSNLEFEVAYK;SLPPLEPS;SPPHKGLQGSHFPEL;TVSWEKSVMEKLENA;WLPGTMLAL 10 12.9 1.003 -2.1529 0 7.72267 12.5217 8.6663 7.31479 0 9.75699 9.40729 0 8.48228 10.66 10.0455 0 10.438 11.1608 A0A8I3N4H7 A0A8I3N4H7_CANLF Pannexin PANX2 PANX Canis lupus familiaris (Dog) (Canis familiaris) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732] gap junction [GO:0005921]; plasma membrane [GO:0005886] channel activity [GO:0015267] AEPEGTAEPPVVKRPRKKMK;ALGLAAAPTKGRP;GGGGDPGPVPDKKHARHFSLDV;GVDASLWPSLFEHKL;KLLPYSLLAF;KYLERRGRSNFLAKL;VPILLVTLVFTKNFAEE 7 17.9 0.98223 -0.24831 0 7.29719 0 0 5.87472 0 7.49458 12.0792 0 0 7.45869 0 10.1273 0 0 A0A8I3N4I5 A0A8I3N4I5_CANLF Ecto-NOX disulfide-thiol exchanger 1 ENOX1 Canis lupus familiaris (Dog) (Canis familiaris) ultradian rhythm [GO:0007624] external side of plasma membrane [GO:0009897] NADH dehydrogenase activity [GO:0003954]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723] EEEMEMSDDEN;EEEMEMSDDENCDSPT;EEMEMSDDENCDSPT;EMEMSDDEN;HVDFAQARDDFY;MSDDENCDSP 6 4.4 1.0037 -1.0592 0 5.83203 6.80697 7.31234 0 7.24289 0 4.98044 0 7.5713 4.12441 4.99557 4.07895 5.23638 0 A0A8I3N4I7 A0A8I3N4I7_CANLF "RAB34, member RAS oncogene family" RAB34 Canis lupus familiaris (Dog) (Canis familiaris) LVSLIGSAKILLI;RPHLAAAESPRPRV;VGSPWPRVI 3 14.9 1.0019 -0.68272 0 0 0 0 0 0 0 8.26987 4.22943 0 0 0 0 6.64731 0 A0A8I3N4I8 A0A8I3N4I8_CANLF Small nuclear ribonucleoprotein U5 subunit 40 SNRNP40 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nuclear speck [GO:0016607]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540] RNA binding [GO:0003723] AAGSGPGAGQQQTAP;RCVKIFQGNVHNFEKN 2 8.7 0.99319 -0.027384 9.99322 0 0 0 0 9.7238 0 0 0 0 0 0 0 0 0 A0A8I3N4I9 A0A8I3N4I9_CANLF "Glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130)" MANEA Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] "glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]" LNYYLHAFYY 1 2.2 0.99076 -0.2686 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.41981 A0A8I3N4J3 A0A8I3N4J3_CANLF Dynein axonemal assembly factor 11 DNAAF11 Canis lupus familiaris (Dog) (Canis familiaris) EGQRYGNVSTT;KLSEKKKKVKPPRILITK;SEKKKKVKPPRIL 3 7 0.87282 0.14336 0 0 0 0 0 4.562 0 0 5.43196 0 8.39695 0 0 0 0 A0A8I3N4K0 A0A8I3N4K0_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] calcium ion binding [GO:0005509] NRDGFIDLEDLHD;YRDAPVDKKGNFNYIEFTRNLKHDA 2 22.1 0.99292 -0.28062 0 0 0 0 0 0 0 0 0 0 0 0 0 7.33619 0 A0A8I3N4K2 A0A8I3N4K2_CANLF Astrotactin 1 ASTN1 Canis lupus familiaris (Dog) (Canis familiaris) neuron migration [GO:0001764] EPKLLFSVRNDFPGEM;FSEVSGYPVL;HIHHQDGAPSL;LEVTRAAPIYELVTNNQ;LSTVHEPSSTLVVL;LVMILYTRRRWC;RRLWLEYEDISKGNS;SKGNSPSDESEERE 8 8.5 0.98942 -0.53008 7.41278 9.02973 9.313 0 7.52795 9.04669 0 0 10.0125 0 0 7.5074 9.76404 0 8.36321 A0A8I3N4K3 A0A8I3N4K3_CANLF A-kinase anchoring protein 13 AKAP13 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] DSILTEEGKNL;DVSLPQISNLNR;EERNSWIQIIQ;EHNKEVAP;GVQNPESQGKNTAHEVS;HRELDVYTL;ISLKKLIV;KEKKKKNKGS;PPGQEALGFCGEPGSAAC;SSALATDQVSLDTGDSVLQ;SYSSDDEEELH;TDMNEGQLMGDFEME 12 5.5 0.99751 -3.767 0 0 11.405 0 0 0 11.0953 8.94793 6.66135 9.07572 9.6474 11.2535 10.4366 0 0 A0A8I3N4K4 A0A8I3N4K4_CANLF Gastrulation brain homeobox 1 GBX1 Canis lupus familiaris (Dog) (Canis familiaris) adult walking behavior [GO:0007628]; neuron fate commitment [GO:0048663]; proprioception [GO:0019230]; regulation of nervous system development [GO:0051960]; sensory neuron axon guidance [GO:0097374]; spinal cord motor neuron differentiation [GO:0021522] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GGGGGGPG;LLYTGYPMFMPYR;PMFMPYRPLVLPQALAPAPL 3 9.4 0.98716 -0.22918 0 0 0 0 0 0 0 10.9134 0 0 0 0 0 0 0 A0A8I3N4K7 A0A8I3N4K7_CANLF "Protein associated with LIN7 2, MAGUK p55 family member" PALS2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] AEGRPAERARRRRRRR;EEERGAGEEGGGEGG;EEERGAGEEGGGEGGG;IEKLRMEPQWVPISWV;NLELVNEILEDITP;RRRRRRRPEPGRS;SGGGAEAA 7 10.3 1.0017 -0.74982 0 0 0 0 4.6842 10.1158 0 10.3419 0 9.49635 6.5354 0 14.1946 0 0 A0A8I3N4K8 A0A8I3N4K8_CANLF Anaphase-promoting complex subunit CDC26 (Cell division cycle protein 26 homolog) CDC26 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979]; regulation of mitotic cell cycle [GO:0007346] anaphase-promoting complex [GO:0005680] LSSDPKSREQMINDRIGYKPQPKP 1 28.2 0.97091 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 6.39571 0 0 A0A8I3N4L4 A0A8I3N4L4_CANLF medium-chain acyl-CoA ligase (EC 6.2.1.2) LOC479821 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] acid-thiol ligase activity [GO:0016878]; CoA-ligase activity [GO:0016405]; nucleotide binding [GO:0000166] FSSWLQGA;GIICANQKGQEIKPGSM 2 4.3 0.98785 -0.46554 0 0 0 0 0 8.0268 0 0 0 0 0 0 0 0 0 A0A8I3N4M4 A0A8I3N4M4_CANLF Interleukin 18 receptor 1 IL1RL1 Canis lupus familiaris (Dog) (Canis familiaris) natural killer cell activation [GO:0030101]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of type II interferon production [GO:0032729]; T-helper 1 cell differentiation [GO:0045063] interleukin-18 receptor complex [GO:0045092] hydrolase activity [GO:0016787]; interleukin-18 binding [GO:0042007]; interleukin-18 receptor activity [GO:0042008] IENINEKNLLFSY;LHEALVERKIKIILIEFTPV;LVERKIKIILI;VHEEDITRIRTL 4 8.3 0.98622 -0.42571 0 0 5.14053 0 0 0 8.0207 10.0073 0 0 0 0 5.31383 0 0 A0A8I3N4N9 A0A8I3N4N9_CANLF Ubiquitin specific peptidase 35 USP35 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] DSSGPGSH;EGEEGAVEFLEQ;IALLKGLAAVKK;LGSVMLPAEDVGVQ;SESGHYYCYAR;SSREEAFTDLSLAFPP 6 6.8 0.99388 -0.019277 0 0 0 0 2.92839 12.8338 6.19733 0 0 8.21179 0 11.1047 1.12022 11.3446 0 A0A8I3N4P7 A0A8I3N4P7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] PEVPKEFSGICAELCLG 1 14.5 0.99534 -0.015142 0 0 0 0 10.8521 0 0 0 0 0 0 0 0 0 10.7498 A0A8I3N4Q3 A0A8I3N4Q3_CANLF Synaptotagmin 9 SYT9 Canis lupus familiaris (Dog) (Canis familiaris) calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059] dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149] DEVFLFPVPYNDLA;LIVKIHKAVNLPAKDF;LPGGAGRG;TKPAPRKLI;VESEDKTLT 5 6.6 1.0041 -1.9849 8.84737 0 0 0 0 10.3876 8.67515 0 0 0 0 0 8.55739 0 10.1187 A0A8I3N4R5 A0A8I3N4R5_CANLF Transmembrane protease serine (EC 3.4.21.-) LOC482174 Canis lupus familiaris (Dog) (Canis familiaris) establishment of skin barrier [GO:0061436]; proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] AERIKKKIERILSESLKTKQLPL;DACKGDSGGPLVY 2 8.2 0.99203 -0.20676 0 0 0 0 0 0 0 0 0 10.9997 0 10.6735 0 0 0 A0A8I3N4S1 A0A8I3N4S1_CANLF Pre-mRNA processing factor 4 PRPF4 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" Cajal body [GO:0015030]; nuclear speck [GO:0016607]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540] U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070] CKVWDLRQRRCVYTIPAHQNL;SKKSKEEQTWYHE 2 6.6 0.99128 -0.22128 0 0 0 0 9.73207 0 0 0 7.35147 0 0 0 0 0 0 A0A8I3N4S9 A0A8I3N4S9_CANLF Cell cycle control protein TMEM30A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] GNVFMYYGLSNFY;GVVLLVINHK;NPFLGIAYIAIGSISFLLGVVLLV;VVLLVINHKY;WMRTAALP 5 15.4 1.0035 -1.9623 0 0 0 0 0 4.41495 10.0603 10.6628 0 0 0 0 5.87207 0 0 A0A8I3N4T1 A0A8I3N4T1_CANLF "Alpha-1,3-glucosyltransferase (EC 2.4.1.-)" ALG8 Canis lupus familiaris (Dog) (Canis familiaris) oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [GO:0042283]" WFEYALSHVAKYFDQEMLNIHNLNY 1 10.3 0.97737 0.035538 0 0 9.73413 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N4T3 A0A8I3N4T3_CANLF Chromosome 11 open reading frame 42 C21H11orf42 Canis lupus familiaris (Dog) (Canis familiaris) GVLGPQKP;GVLVKQSRPAH;LHMGGLRK;QVSLQQNLPWLRSTHSIYVIYQ 4 14.7 1.0031 -1.5328 5.9381 4.65254 0 0 0 0 9.61025 6.96405 0 0 0 0 0 0 0 A0A8I3N4T5 A0A8I3N4T5_CANLF Protein transport protein SEC23 SEC23A Canis lupus familiaris (Dog) (Canis familiaris) COPII-coated vesicle cargo loading [GO:0090110]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789] GTPase activator activity [GO:0005096]; zinc ion binding [GO:0008270] DEDLQALKESMQMSLSLLPP;PPEPVLLD;SGVALSIA;SPFLQVFNNSPD;VPVAALFTPLK 5 8 0.98734 -0.47948 0 0 0 0 0 0 6.33623 0 0 0 12.0767 2.95241 12.4128 0 0 A0A8I3N4U3 A0A8I3N4U3_CANLF "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase)" ALG2 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; response to calcium ion [GO:0051592] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "alpha-1,3-mannosyltransferase activity [GO:0000033]; calcium-dependent protein binding [GO:0048306]; GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity [GO:0102704]; protein heterodimerization activity [GO:0046982]" AIFKETFKSLSHIEPDVLYPS;IMAGGYDERVLEN;VLKLARRRKKI 3 10.8 0.98835 -0.47618 0 0 0 0 0 5.26536 8.99348 0 0 0 0 0 0 0 0 A0A8I3N4U6 A0A8I3N4U6_CANLF Uncharacterized protein LOC106558903 Canis lupus familiaris (Dog) (Canis familiaris) EGNGQAGA;FGNGNGLA;PTPGISWGLK;SPPKPGYLPGP 4 8.4 1.0029 -1.5126 0 0 9.52374 0 0 10.9732 0 0 9.34756 7.03254 8.88487 0 0 0 11.288 A0A8I3N4V5 A0A8I3N4V5_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] endomembrane system [GO:0012505]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] AALSREGLE;ALFVYDKGAQV;LVPDDNLLLGYCLIPFTGV 3 7.6 0.98801 -0.47425 0 0 0 0 0 0 11.5125 0 0 0 10.1555 0 0 0 0 A0A8I3N4V9 A0A8I3N4V9_CANLF MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase MFNG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glycosyltransferase activity [GO:0016757] SLHCLLYPDTPWCPL;TLSYGVFE 2 7.6 0.99196 -0.2093 0 0 0 0 7.48768 0 0 0 11.7178 0 0 0 0 0 0 A0A8I3N4W2 A0A8I3N4W2_CANLF Serine/threonine kinase 32B STK32B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] FELEEMIL;KDPESRLSSLGDVQ;PFLVNLWYSFQDEEDM 3 11.3 0.98901 -0.26134 0 7.90863 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N4W7 A0A8I3N4W7_CANLF Low-density lipoprotein receptor-related protein LRP5 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; endocytosis [GO:0006897] plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] AEDNGGCSHLCL;CASHYTLDPSSR;CDGFPECDDQSDEEGCPV;DEITKPPSDDTPA;DPLEGYVYWTDDEV;DYPEGMAVDWVGK;ECDDQSDEEGCP;GSTRKIIVDSDIYW;IVVNAERGYLYFTNMQDRA;LSIDIYSRTLFWTCEAANTINVHR;PFPGISCGKSM;RLVDAGGV;SRMIPDDQHSPDL;YLDGSGAQTLVNTEIND 14 12 1.0031 -2.3509 0 6.3752 5.91936 7.03958 9.03136 0 8.26562 0 7.2268 9.9441 0 7.14445 11.8445 9.47575 0 A0A8I3N4X3 A0A8I3N4X3_CANLF Advillin AVIL Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; cilium assembly [GO:0060271]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480] actin filament [GO:0005884]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027] actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933] GAESAMFKQLFQKWS;LKYYPIEVL;LPSRPRNASAMSLSSAFRA;LVIFEGGTSRTGNAEPD;RDRERGGRAE;RERGGRAEIGVIE;YLSEQDFISVFGI 7 10.5 1.0024 -1.4007 0 0 0 0 0 9.27433 0 7.63234 0 0 6.47836 8.76805 9.38146 0 0 A0A8I3N4X8 A0A8I3N4X8_CANLF 40S ribosomal protein S27 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735] KRKHKKKRLVQ 1 14.1 0.98479 0.035491 0 0 0 0 0 0 0 0 6.06232 0 0 0 0 0 0 A0A8I3N4Y6 A0A8I3N4Y6_CANLF Fascin FSCN2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; eye photoreceptor cell development [GO:0042462] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; stereocilium [GO:0032420] actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674] ATAISPAELWTVHLA;HLGRYLSAEEDGRV;TLVAHGGI 3 7.5 0.99624 -0.10161 0 0 0 0 9.04363 0 8.03672 0 0 5.00027 0 0 0 0 9.67393 A0A8I3N4Z8 A0A8I3N4Z8_CANLF Transmembrane protein 8B TMEM8B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] FSTFYHACDQ;LDTFSVHFYI;LDTFSVHFYIFFGP;LFHFHVPE;PLPQSPLQPL;PPWGHWVYV 6 5.5 0.98739 -0.50202 0 11.4224 0 0 0 0 0 12.3653 0 0 0 0 0 0 0 A0A8I3N503 A0A8I3N503_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 2 ADAMTS2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AARRLLCPALLLLLLLPPPLLLPP;LLLLLLLP 2 4.4 0.97308 0.041303 0 0 0 0 0 0 0 0 0 0 0 3.01801 0 0 0 A0A8I3N507 A0A8I3N507_CANLF NEDD4 binding protein 3 N4BP3 Canis lupus familiaris (Dog) (Canis familiaris) dendrite [GO:0030425]; vesicle [GO:0031982] EPSLSDSSSG;GPLAMLNCLPEP;LREAVRSLQEQGP 3 6.4 0.98956 -0.52178 0 0 0 0 0 0 0 0 7.85294 0 0 11.3647 0 0 0 A0A8I3N511 A0A8I3N511_CANLF B-box and SPRY domain containing BSPRY Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830] IFERTEEAEG 1 2.6 0.99028 0.024622 0 0 0 0 0 0 13.0656 0 0 0 0 0 0 0 0 A0A8I3N524 A0A8I3N524_CANLF Protein jagunal homolog 1 JAGN1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to fungus [GO:0050832]; endoplasmic reticulum organization [GO:0007029]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; neutrophil differentiation [GO:0030223]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum membrane [GO:0005789] LVLSMISMGLFSI 1 7.1 0.94282 0.059681 0 0 0 0 0 0 0 0 0 0 4.84539 0 0 0 0 A0A8I3N540 A0A8I3N540_CANLF WW domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] KQQGHEPVSPRSLQRSN;QQPVTADKQQGH;VSQWFPKRRQ 3 6.7 0.9891 -0.26514 0 0 0 0 0 0 0 10.8115 0 0 0 0 0 0 0 A0A8I3N548 A0A8I3N548_CANLF Olfactory receptor family 56 subfamily A member 3C OR56A3C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CTFMVMAY;LVLIFISYSLILQTVM;QMFIMNFFYAMESCTFMVMAY 3 11.7 0.93071 0.096399 0 0 0 0 0 0 0 5.91574 0 8.12122 0 0 0 0 0 A0A8I3N558 A0A8I3N558_CANLF "ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1)" SUPV3L1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962] mitochondrial degradosome [GO:0045025]; mitochondrial nucleoid [GO:0042645]; nucleus [GO:0005634] "3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; hydrolase activity, acting on acid anhydrides [GO:0016817]; protein homodimerization activity [GO:0042803]" AENQSRLSGAL;KPTINEKGEK;QSRLSGALKSQARRMR;SSSSASGGSKAPNTSL;VATDAIGMGLNLSIRRIIF;VGAELTRPLDKNEV;VLDHALESLDNL 7 10.7 1.0037 -1.0716 0 0 9.62278 0 10.9085 10.9112 0 0 13.5587 0 0 0 0 0 13.1332 A0A8I3N561 A0A8I3N561_CANLF "Glycerol-3-phosphate acyltransferase 2, mitochondrial" GPAT2 Canis lupus familiaris (Dog) (Canis familiaris) glycerol-3-phosphate metabolic process [GO:0006072]; phosphatidic acid biosynthetic process [GO:0006654]; piRNA processing [GO:0034587]; triglyceride biosynthetic process [GO:0019432] membrane [GO:0016020]; mitochondrion [GO:0005739] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366] AEGRYFRV;LRALLKKLGGLFLPPEA;LRCLVQHTLS;PSLWSVPLQLSQ;SGDFTDSDSDDFEEAEG 5 7.6 1.0025 -1.0122 0 0 0 0 0 0 4.28385 0 0 0 0 0 0 9.14637 0 A0A8I3N570 A0A8I3N570_CANLF "Mucin 2, oligomeric mucus/gel-forming" MUC2 Canis lupus familiaris (Dog) (Canis familiaris) CATKGIMLWGWREQVCNED;CGPNGTVERHFNVCVT;CSCDSGGDCECFCSA;CSCDSGGDCECFCSAVASYAQEC;DCNTCTCQRGRWTCTQSVCYGSCSI;DECEWHYEPCGNRSF;DSCSCDSGGDCEC;DSCSCDSGGDCECFC;DSCSCDSGGDCECFCSAVAS;DSCSCDSGGDCECFCSAVASYAQ;DTCNCQNSESCMC;EACVHDSCSCDSG;EEHHMDGCFCPEGT;FYEACVHDSCSCDSGGDCE;GVVCDDPEEE;HDSCSCDSGGDCEC;HYQTECVSGCICP;NCQNSESCM;NECEECVCTAGRW;SCDSGGDC;SCSCDSGGDCEC;SCSCDSGGDCECFC;SNCHDKLDWLDDP;SYVAAQDYC;VHDSCSCDSGGDCECFCSAV;YSPGDKIKVDCNTCTCQRGRWTCTQ;YYKRCKYDTCNCQN 27 16 0.99699 -0.58964 0 0 0 0 0 0 0 0 0 0 10.8625 0 0 0 0 A0A8I3N577 A0A8I3N577_CANLF "Small ribosomal subunit protein uS5m (28S ribosomal protein S5, mitochondrial)" MRPS5 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrial small ribosomal subunit [GO:0005763] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] AVHYLHYIERYEDH;GARKGRGK;LSYPGTRNNHH;SYPGTRNNH 4 7.7 1.0029 -1.5351 0 0 4.40892 0 0 0 0 9.40812 0 0 3.78031 8.50613 0 3.40108 5.16591 A0A8I3N592 A0A8I3N592_CANLF Solute carrier family 2 member 6 SLC2A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ALMAGAHGFWML;FAGGLTAACIPVYV;WEFEQIQDN 3 7.9 1.0017 -0.69275 0 0 0 0 7.29195 0 0 0 0 7.20438 9.01737 8.84216 0 0 0 A0A8I3N593 A0A8I3N593_CANLF DEP domain containing MTOR interacting protein DEPTOR Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TORC2 signaling [GO:1903940]; positive regulation of autophagy [GO:0010508]; regulation of extrinsic apoptotic signaling pathway [GO:2001236] lysosomal membrane [GO:0005765] phosphatidic acid binding [GO:0070300]; protein serine/threonine kinase inhibitor activity [GO:0030291] EQLRLRLHEE;IVMEVMEELEC;LYEKLMSPENTLLQAREEEGVKYE 3 11 1.0038 -0.8148 0 9.27747 0 0 9.09342 0 0 0 0 0 0 0 0 0 0 A0A8I3N596 A0A8I3N596_CANLF Speriolin N-terminal domain-containing protein SPATC1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein kinase A signaling [GO:0010739]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; membrane [GO:0016020] protein kinase A regulatory subunit binding [GO:0034237] PLADSAERRAQARDSERSQQGG;VLAPAPTP 2 3.6 0.9763 0.048004 0 0 0 0 0 0 0 0 0 0 10.0541 0 0 0 0 A0A8I3N5A1 A0A8I3N5A1_CANLF GVQW motif containing 3 GVQW3 Canis lupus familiaris (Dog) (Canis familiaris) EEPKPRRFDFLSDL 1 6.7 0.93881 0.060957 0 0 0 0 0 11.0311 0 0 0 0 0 0 0 0 0 A0A8I3N5A4 A0A8I3N5A4_CANLF Fibronectin type III domain containing 4 FNDC4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of inflammatory response [GO:0050728]; response to transforming growth factor beta [GO:0071559] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] AATEPFWAV;ALWGLAED;VGTMASLMPLSP 3 10.2 1.0022 -0.7641 0 0 0 0 0 0 0 0 0 0 0 8.33972 0 0 0 A0A8I3N5A5 A0A8I3N5A5_CANLF Solute carrier family 5 member 7 SLC5A7 Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine biosynthetic process [GO:0008292] early endosome membrane [GO:0031901]; neuromuscular junction [GO:0031594]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672] choline:sodium symporter activity [GO:0005307] LDELAPVKPRQS;LLVGAFTMTATWVGGGYINGTAEAV;SEAIIVGG 3 7.8 0.99204 -0.17679 0 0 0 0 10.5413 10.6484 0 0 0 0 7.96446 0 0 0 0 A0A8I3N5A6 A0A8I3N5A6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LRPLVKPKIVNKRTK 1 11.1 0.95087 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.09803 A0A8I3N5B1 A0A8I3N5B1_CANLF Tubulin--tyrosine ligase (EC 6.3.2.25) TTL Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] spindle microtubule [GO:0005876] tubulin-tyrosine ligase activity [GO:0004835] SYNRKKEDGEGNVWIAKSSA 1 5.3 0.95053 0.056332 0 0 7.6907 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N5B8 A0A8I3N5B8_CANLF Actin-related protein 2/3 complex subunit 3 Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314]; regulation of actin filament polymerization [GO:0030833] Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737] actin binding [GO:0003779] ETKDTDIVDEAI;PANKQEDEVM 2 14.1 0.99085 -0.2751 0 0 0 0 0 0 0 0 0 0 0 0 8.41312 0 0 A0A8I3N5D7 A0A8I3N5D7_CANLF CD24 molecule CD24 Canis lupus familiaris (Dog) (Canis familiaris) cell activation [GO:0001775]; cell adhesion [GO:0007155]; regulation of cell-cell adhesion [GO:0022407] external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121] protein tyrosine kinase activator activity [GO:0030296] VARLGLGLLLLALLL 1 19.5 0.95057 0.053874 0 0 0 0 2.17954 0 0 0 0 0 0 0 0 0 0 A0A8I3N5F4 A0A8I3N5F4_CANLF Calcium voltage-gated channel auxiliary subunit beta 4 CACNB4 Canis lupus familiaris (Dog) (Canis familiaris) "adult walking behavior [GO:0007628]; cAMP metabolic process [GO:0046058]; cellular response to leukemia inhibitory factor [GO:1990830]; detection of light stimulus involved in visual perception [GO:0050908]; gamma-aminobutyric acid secretion [GO:0014051]; gamma-aminobutyric acid signaling pathway [GO:0007214]; muscle cell development [GO:0055001]; neuromuscular junction development [GO:0007528]; neuronal action potential propagation [GO:0019227]; Peyer's patch development [GO:0048541]; regulation of synaptic vesicle exocytosis [GO:2000300]; spleen development [GO:0048536]; synaptic transmission, glutamatergic [GO:0035249]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]" glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels [GO:0099626] EDVPVPSTAISF;GPSPSPASPPSP;QDTYKPHRN 3 6.5 0.98734 -0.49708 0 9.63379 0 0 0 0 0 0 0 0 0 12.5458 0 0 0 A0A8I3N5F7 A0A8I3N5F7_CANLF TNF receptor-associated factor TRAF4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of JNK cascade [GO:0046330]; regulation of apoptotic process [GO:0042981]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270] AQHAASECPKRTQPCTYCTKEF;CEFCGCDFSGEAFESHE;CGCDFSGE;EFCGCDFSGE 4 8.3 1.0035 -1.6216 6.26486 0 0 3.02591 8.58391 0 0 0 0 0 0 0 0 6.51616 0 A0A8I3N5G6 A0A8I3N5G6_CANLF Keratin 26 KRT26 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] EEELQQIR 1 1.7 0.98864 -0.26066 8.36811 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N5H1 A0A8I3N5H1_CANLF Zinc finger protein 18 ZNF18 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GEIQMWVRKQC;GEKPYKCPICEKS;QENDKENLNLEN 3 6.6 0.986 -0.42854 6.15192 0 0 0 0 0 0 9.14338 0 0 9.76691 0 0 0 0 A0A8I3N5H2 A0A8I3N5H2_CANLF Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; transferase activity [GO:0016740] TQKTVDGPSGKLWC;VAGAGIVL 2 6.6 1.004 -1.1044 8.55025 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N5H6 A0A8I3N5H6_CANLF Zinc finger CCCH-type containing 13 ZC3H13 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] DRRDERARERDRERERDRERERERE;ERERERERDREREKERELERERARE;ERERERERERARERDKERERQRDWE;ERERERERERDREREKERELERE;GDDKNRQDSRSHSSRRSS;GPELPEKGSRG;KEREREREERERERERERERERERA;RAREREREREREKERDRERERDR;RDERARERDRERERDRERERERERE;SSYPERDRYPERDNRDQARDSSFER;SVQGFEDISKAERTESVEG 11 20.4 0.97053 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.68032 A0A8I3N5I3 A0A8I3N5I3_CANLF Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) RPLP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translational elongation [GO:0002182] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] APAAAEEKKDEKKEESEESDDDMGF;EESEESDDDM 2 21.7 0.97477 0.035538 0 0 0 0 0 0 0 0 7.48752 0 0 0 0 0 0 A0A8I3N5I7 A0A8I3N5I7_CANLF WD repeat domain 41 WDR41 Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] ISALIEIPKNCVV;RESGLRSLKLFQKL;SPQLDTQQE;TQQEIKLCQKPNDISIHHFTWDEEN 4 14.1 0.9917 0.0041946 0 0 0 0 0 0 8.08874 8.5871 0 0 0 11.3699 0 0 0 A0A8I3N5K9 A0A8I3N5K9_CANLF Uncharacterized protein CCL23 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] ESMVAKQQHE 1 8.4 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 8.75529 8.84238 0 0 0 0 A0A8I3N5L4 A0A8I3N5L4_CANLF Nuclear pore associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) AASASLPASMAPG;ATGHHNGPPIPTEHT;HHNGPPIPTEHTEPPQ;VGGAGAPT 4 3.8 0.99138 -0.0049379 0 0 0 0 8.60118 0 0 0 10.1438 0 0 10.0723 9.23278 0 0 A0A8I3N5L5 A0A8I3N5L5_CANLF M-phase inducer phosphatase (EC 3.1.3.48) CDC25A Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; positive regulation of cell cycle G2/M phase transition [GO:1902751] protein tyrosine phosphatase activity [GO:0004725] AGEKSKREMYSR;KGTIENILDNDPRDL;LGSEYEQALEVRNSSLQ 3 9.1 0.99248 -0.29094 0 0 8.26552 0 0 0 0 9.048 0 12.806 0 0 0 0 0 A0A8I3N5M1 A0A8I3N5M1_CANLF N-acetylglucosamine-1-phosphate transferase subunits alpha and beta GNPTAB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "calcium ion binding [GO:0005509]; transferase activity, transferring phosphorus-containing groups [GO:0016772]" AEQLIALKRKILPRRRIQKEASPDR;EQKAMSEKQL;FAFSYFYYLMSAIQPLNISQ;FFAEQLIALKRKILPRR;INCSKMLPANITQ;IRTLATRIHDLPLSLQDL;LIALKRKILPRRRI;LIALKRKILPRRRIQ;LPREYRNRFL;QLIALKRKILPRRRIQKEA;VLDPALPANVTLK;VLRDFYESMFPI;YSDNPIIRHA;YTDSYLGFLPWEKKKYFQ 14 12.1 1.0043 -1.0766 11.0509 8.13924 12.9376 0 0 7.14405 8.22299 0 5.73717 10.2343 0 0 10.9744 11.8888 0 A0A8I3N5M8 A0A8I3N5M8_CANLF ADAM metallopeptidase domain 30 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] IVEGNEDCDCGS;NDELEKLIAE;TEIWTNEDKININ;VGYHKAMIPM;VGYHKAMIPMGIP;YMCREEDNECDLAEY 6 9.2 0.99257 -0.55215 6.86876 0 8.47119 0 11.3538 0 7.20212 0 0 0 0 0 0 0 5.92298 A0A8I3N5N6 A0A8I3N5N6_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) SIAH3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein targeting to mitochondrion [GO:1903215]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] IVFLATDM 1 3 1.0048 -1.1044 0 0 0 0 0 0 0 0 11.7297 0 0 0 0 0 0 A0A8I3N5N7 A0A8I3N5N7_CANLF Coiled-coil domain containing 83 CCDC83 Canis lupus familiaris (Dog) (Canis familiaris) EEENLVLIDQLFNCR;EKAMKEKWKF;EVKLPTSEALLEYHCQ;FIDKGSYREIWENDW;VEELESTIH 5 15.8 1.002 -1.836 9.5218 0 0 0 0 0 9.45664 11.4844 0 0 0 0 0 0 8.75185 A0A8I3N5N8 A0A8I3N5N8_CANLF Ceramide kinase CERK Canis lupus familiaris (Dog) (Canis familiaris) kinase activity [GO:0016301] PGADACSV;VCFSTVGTNDAETSALHIIVGDSL 2 6 1.0036 -1.0631 7.14241 0 0 0 0 0 0 9.07617 0 0 0 0 7.13268 0 0 A0A8I3N5P0 A0A8I3N5P0_CANLF Carboxypeptidase B2 CPB2 Canis lupus familiaris (Dog) (Canis familiaris) fibrinolysis [GO:0042730]; proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] FQSGQVLSAFPR;GVLVAIFLLCE;IENTNKNTRYTHGSG;IKAYISMHSYSQHIVFPYS;SEPEVKAMANF;TIELRDTG 6 19.7 1.0034 -0.89106 0 0 8.02309 0 9.91549 0 0 0 0 0 0 0 8.60566 0 0 A0A8I3N5P8 A0A8I3N5P8_CANLF Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) EIF2B4 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] translation initiation factor activity [GO:0003743] DLVITELGMI;INNGDVILVYGC;LQLRKEKKQQKKKRKEEKGAE;QEEKLQLRKEKKQQKKKRKEEK;YTTPPNEELSRDLV 5 11.6 0.98731 -0.36096 4.68319 0 0 0 6.73904 0 0 9.2988 0 0 0 0 0 0 0 A0A8I3N5R8 A0A8I3N5R8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DHFSRRFSPRR 1 6.9 0.98416 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.90323 A0A8I3N5S7 A0A8I3N5S7_CANLF Solute carrier family 13 member 2 SLC13A2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lithium ion [GO:0071285] apical plasma membrane [GO:0016324] alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; fumarate transmembrane transporter activity [GO:0015138]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141] AYRSYLIVLLL;EVCIEYFKDSNI;IVLLLPVLLLPLPILIPTK;LIVLLLPVLLLP;MAILLLLSWLWL;RIALRVLLIIGVRPALL;SYLIVLLLPVLLLPLPILIPTK 7 11.2 0.98752 -0.22863 0 0 0 0 0 0 10.6466 0 0 0 0 0 7.92059 0 0 A0A8I3N5U1 A0A8I3N5U1_CANLF Rho guanine nucleotide exchange factor 17 ARHGEF17 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AAVQLPDGFNLLCPTPPPP;CLHISIAGS;PSLEHRDSPRNRGP;TLAQFTIALEDM;TSPSTVSCPRAPLSPAGLGQGHT 5 7.4 0.95319 0.05044 0 0 0 0 0 6.69572 0 0 0 0 0 0 0 0 0 A0A8I3N5W6 A0A8I3N5W6_CANLF Nestin NES Canis lupus familiaris (Dog) (Canis familiaris) G2/M transition of mitotic cell cycle [GO:0000086]; stem cell proliferation [GO:0072089] cytoplasm [GO:0005737]; intermediate filament [GO:0005882] intermediate filament binding [GO:0019215]; structural molecule activity [GO:0005198] DGLETFLYPEK;DLQEEGKNREDSEADEL;DNQETLKPLEKETQ;EEDKLDRPN;EVGLPVETQ;LEGEDQGTLRP;PESLNSLGEGNLE;QEPVGSLEEED;SLEKENQEPVRSLVED 9 7.4 1.0026 -1.8519 0 0 10.0519 0 0 11.6399 8.38254 0 0 10.1625 0 0 0 9.42112 4.26978 A0A8I3N5W8 A0A8I3N5W8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] FLAEGGGT;PVSWADETDGLE 2 9.9 1.0018 -1.317 0 0 0 0 0 0 0 0 12.1463 0 0 12.1259 9.0165 0 0 A0A8I3N5X1 A0A8I3N5X1_CANLF NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) NKIRAS2 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; lung alveolus development [GO:0048286]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; Ral protein signal transduction [GO:0032484]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; surfactant homeostasis [GO:0043129] cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924] KSCKVVVC 1 4.2 1.0047 -1.1044 6.34298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N5X3 A0A8I3N5X3_CANLF TATA-box binding protein associated factor 13 TAF13 Canis lupus familiaris (Dog) (Canis familiaris) EEYCPSKDD;LDGQWDEVLQFIQPLEC;QEYYRQRLRYQQHLEQKEQQRQIYQ;QHLEQKEQQRQIYQQMLL;TEQFQEYYRQRLRYQ;VGSNSKTLRVCAYPEVID;WHTQDLSFL 7 10.2 1.0039 -1.9879 9.54901 0 0 0 8.25248 0 7.30843 0 10.2879 0 5.96576 0 0 10.7428 7.73457 A0A8I3N5X9 A0A8I3N5X9_CANLF [Wnt protein] O-palmitoleoyl-L-serine hydrolase (EC 3.1.1.98) NOTUM Canis lupus familiaris (Dog) (Canis familiaris) bone development [GO:0060348]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of bone mineralization [GO:0030500] extracellular region [GO:0005576] lipase activity [GO:0016298]; palmitoleyl hydrolase activity [GO:1990699] CFNRENCDSRYD;LLFLEGGWYCFNREN;SPAGYYLKESKGSRR;TDVQVKGTSLPRA;VHLVDSCPWPHCNPS 5 12.8 0.98495 -0.24641 10.5235 9.81542 0 0 0 10.2212 0 0 5.78333 0 0 0 10.2257 0 0 A0A8I3N601 A0A8I3N601_CANLF Hepatocyte nuclear factor 1-beta (Transcription factor 2) HNF1B Canis lupus familiaris (Dog) (Canis familiaris) insulin secretion [GO:0030073]; liver development [GO:0001889]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677] MAIAQMPPPSL 1 2.4 0.9887 0.035491 4.46421 3.81813 0 7.79409 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N606 A0A8I3N606_CANLF Upstream binding transcription factor UBTF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DEDEDEEEEDDENGDSSEDG;DEDEEEEDDEN;DEEDEDEDEEEEDDEN;DEEDEDEDEEEEDDENGDS;DEIMRDYIQKHPEL;DQKKKDYEVELL;EDEDEEEE;EDEDEEEEDDENGDSSEDGGDSSE;EDEEDEDEDEEEEDDENGDSSE;GDSSEDGGDSSESSSEDESEDGD;GVGWGVPKSSVRPSTPAAR;SESEEDDEEDEEDED;SESEEDDEEDEEDEDED;SESEEDDEEDEEDEDEDEE;SESEEDDEEDEEDEDEDEEEED;SKSESEEDDEEDE;SKSESEEDDEEDEEDED 17 9.7 0.94837 0.055325 0 0 0 0 0 8.65356 0 0 0 7.06706 7.14425 0 0 6.71012 0 A0A8I3N624 A0A8I3N624_CANLF "Corin, serine peptidase" CORIN Canis lupus familiaris (Dog) (Canis familiaris) peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ASRRCDGQADCDDDSDEENC;CDDDSDEENCGCKERDLWECPT;CDGQADCDDDSDEENCGCKER;CDGYDDCGDL;CIPSTFRCDGDEDCRDGTDE;DCDDDSDE;GMDEKNCSFCHDDELE;GYDDCGDLSDE;HATPTPLF;HNDCGDWSDEAQCNCSE;LDSSDEWDCVTL;LQEGEVRIISLEQCQAYFDMK;PECVGDGDSHGLL;PLVTDGEVPVSEI;QWPEDTDCSQFPEENSD;RCDGQADCDDDSDEENC;RCDGQADCDDDSDEENCGC;VICDGFPDCPDGMDE;VLGMVNASWPDFLA;VLIPCICALIVLLV;YKYLMFFACTVLV;YSLVCDGYDDCGDLSDEQNCAC 22 24.1 0.97717 0.046227 6.87713 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N631 A0A8I3N631_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FERMIFICCVIMLL 1 4.4 0.93785 0.060957 0 0 0 0 0 0 8.49402 0 0 0 0 0 0 0 0 A0A8I3N633 A0A8I3N633_CANLF Mitoguardin 1 MIGA1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fusion [GO:0008053] membrane [GO:0016020]; mitochondrion [GO:0005739] HREVRHTYRLESLCHCPFY;IFLAHHFKRKRGKK;TDHWDSTEMELAA;TELLMAYLGA;VSWYYSLSQIKF 5 11.3 0.98737 -0.40592 8.06512 0 0 0 0 0 0 5.24888 5.46715 0 0 0 0 8.14858 0 A0A8I3N636 A0A8I3N636_CANLF "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2)" NDUFV1 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" cytosol [GO:0005829]; mitochondrial respiratory chain complex I [GO:0005747] "4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]" EERMQRFAQQHQ 1 2.6 0.98498 -0.23701 0 7.67023 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N641 A0A8I3N641_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3" SMARCD3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SWI/SNF complex [GO:0016514] transcription coregulator activity [GO:0003712] SVRCTLLLMLDYQPPQ;YHQPWSQEAVSRYFYC 2 6.8 0.99081 -0.13772 0 0 0 0 0 0 0 0 0 0 0 0 5.05041 0 0 A0A8I3N650 A0A8I3N650_CANLF "2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37)" CNP Canis lupus familiaris (Dog) (Canis familiaris) cyclic nucleotide catabolic process [GO:0009214] melanosome [GO:0042470]; membrane [GO:0016020] "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]" EELGNHKAFKKELRHFVS;VLDDTNHERE 2 7.4 0.98199 -0.25082 0 0 0 9.18257 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N663 A0A8I3N663_CANLF Betaine--homocysteine S-methyltransferase 2 BHMT2 Canis lupus familiaris (Dog) (Canis familiaris) methionine biosynthetic process [GO:0009086]; methylation [GO:0032259] S-methyltransferase activity [GO:0008172]; zinc ion binding [GO:0008270] AGLQAHLIV;EDNMGSKY 2 5.7 1.0022 -0.76586 0 0 0 0 0 12.396 0 0 0 0 0 0 0 0 0 A0A8I3N669 A0A8I3N669_CANLF NTF2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] PQGRKKVWHSFQG 1 2.5 0.94242 0.059626 0 9.63183 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N673 A0A8I3N673_CANLF Synapsin III SYN3 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269] synaptic vesicle [GO:0008021] AHTDWTKY;FCSKPWVFSQLIKIFHSLGPEK;RQMAKVDGIPWDIGYRQQIWGQSE 3 18.9 0.99397 -0.28582 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.52697 A0A8I3N675 A0A8I3N675_CANLF "NFATC2-interacting protein (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)" NFATC2IP Canis lupus familiaris (Dog) (Canis familiaris) VLANSPEAAEMSQLLQLRV 1 13.6 0.95125 0.049862 0 0 8.86672 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N679 A0A8I3N679_CANLF FAM193 C-terminal domain-containing protein FAM193B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] CSGHCGGP;PEAPVEPDRDG;SSSSSCHG 3 3.3 0.98714 -0.2312 0 0 0 9.75889 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N694 A0A8I3N694_CANLF Poly [ADP-ribose] polymerase (EC 2.4.2.30) PARP1 Canis lupus familiaris (Dog) (Canis familiaris) "apoptotic process [GO:0006915]; ATP generation from poly-ADP-D-ribose [GO:1990966]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; mitochondrial DNA repair [GO:0043504]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of single strand break repair [GO:1903518]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromatin [GO:0071168]; regulation of base-excision repair [GO:1905051]; regulation of protein localization [GO:0032880]; replication fork reversal [GO:0071932]" chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; site of double-strand break [GO:0035861]; transcription regulator complex [GO:0005667] damaged DNA binding [GO:0003684]; NAD binding [GO:0051287]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-histone H2BS6 serine ADP-ribosyltransferase activity [GO:0140816]; NAD+-histone H3S10 serine ADP-ribosyltransferase activity [GO:0140817]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-histidine ADP-ribosyltransferase activity [GO:0140815]; NAD+-protein-tyrosine ADP-ribosyltransferase activity [GO:0140808]; nucleosome binding [GO:0031491]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; zinc ion binding [GO:0008270] IDRWYHPN;ISYLKKLKIKKQDRIFPPE;SYLKKLKIK 3 2.7 1.0024 -1.8592 0 5.75336 0 0 0 0 0 0 0 0 0 5.44447 0 3.67762 0 A0A8I3N6A3 A0A8I3N6A3_CANLF Prolyl endopeptidase (EC 3.4.21.-) PREP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DPYAWLEDPDSEQT;IDNFEGEYDYVTN;LVAACANQR;LVPEHEKDVLEWVACVR;MWQKVQDYHGHKIYDPYAWLEDP;YSGQKKDTEIFYQFTS 6 11.9 0.97887 0.046276 0 0 0 0 0 0 0 0 0 6.59489 0 0 0 0 0 A0A8I3N6A6 A0A8I3N6A6_CANLF Olfactory receptor LOC541568 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GGVEIFVLTGMAYDR;LGGVEIFV;VLFIYIRPA 3 7.6 0.98746 -0.46074 10.5443 0 0 0 0 0 0 11.0612 0 0 0 0 0 8.59842 0 A0A8I3N6B0 A0A8I3N6B0_CANLF Tetraspanin TSPAN15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AADIPVHHPG;GGQGAGSE 2 3 0.98949 -0.52989 0 0 0 0 0 0 8.84721 0 0 0 0 10.78 0 0 0 A0A8I3N6B1 A0A8I3N6B1_CANLF Coiled-coil domain containing 12 CCDC12 Canis lupus familiaris (Dog) (Canis familiaris) post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684] EQLEAAKPEPIIEEVD;LAPRKPDWD;VAKKLEKLEKRTQR 3 22.2 1.0021 -0.69114 9.03991 0 0 0 0 0 0 0 0 8.81567 0 0 0 0 0 A0A8I3N6C0 A0A8I3N6C0_CANLF Uncharacterized protein NRGN Canis lupus familiaris (Dog) (Canis familiaris) TSMDCCTESACSKPDDD 1 9.5 0.9833 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 5.75582 0 0 A0A8I3N6C2 A0A8I3N6C2_CANLF Erythrocyte membrane protein band 4.1 like 4A EPB41L4A Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] KQLTRTITLFPP;QENDMVDSAPQW;RILAPSPVKSFKKAKNENSPDA 3 7.2 0.95493 0.05044 0 0 0 0 7.03826 0 0 0 0 0 0 0 0 0 0 A0A8I3N6C4 A0A8I3N6C4_CANLF Flavin-containing monooxygenase (EC 1.-.-.-) FMO5 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; regulation of cholesterol metabolic process [GO:0090181] endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" INNFLEKKMNQRFDH;LVKVKGNVKEFTETAAIFE;NVKEFTETAAIFEDGS;SKEMMCFSDYPIPDHYPNFM 4 13.6 0.98686 -0.3829 0 0 0 8.98729 0 0 0 0 7.91007 7.15249 0 0 10.512 0 0 A0A8I3N6C5 A0A8I3N6C5_CANLF Olfactory receptor OR52X1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RTERSLHHPMFFFL;TERSLHHPMFFF 2 4.4 0.98738 -0.37117 8.347 0 0 0 0 0 0 10.1549 10.1724 0 0 0 0 0 0 A0A8I3N6D2 A0A8I3N6D2_CANLF V-type proton ATPase subunit C ATP6V1C1 Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; proton-transporting V-type ATPase, V1 domain [GO:0033180]; synaptic vesicle membrane [GO:0030672]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" RLMTSDTKPGK;YETLAEMVVP 2 7.8 0.98292 -0.256 0 0 0 0 0 0 0 0 11.6525 0 0 0 0 0 0 A0A8I3N6E1 A0A8I3N6E1_CANLF Zinc finger protein 180 ZNF180 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QEKQETLLKEMAF 1 2 0.94022 0.059711 0 0 0 0 0 0 0 0 0 0 0 0 0 9.66295 0 A0A8I3N6E6 A0A8I3N6E6_CANLF Uncharacterized protein PRSS22 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] VHLLPNTRCWI 1 3.6 0.99248 -0.1923 0 0 0 9.78834 0 0 0 0 0 0 0 0 0 13.1931 0 A0A8I3N6F2 A0A8I3N6F2_CANLF Adipogenesis associated Mth938 domain containing AAMDC Canis lupus familiaris (Dog) (Canis familiaris) FLMSSPEIASLSWGQMK 1 10.5 0.97714 0.046227 0 0 0 0 0 0 0 0 9.86708 0 0 0 0 0 0 A0A8I3N6F4 A0A8I3N6F4_CANLF Zinc finger protein 746 ZNF746 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin protein ligase binding [GO:0031625] EAHGTLFGPGQATRFFPSP;GVHSNFSTTIPPTS;NHAAGAKA;VPVDPSPGSGPPVPAPDL 4 9.3 0.98926 -0.50899 0 0 0 0 0 8.22516 0 7.3672 10.5717 9.49015 0 0 10.0235 0 11.106 A0A8I3N6G3 A0A8I3N6G3_CANLF Zinc finger protein 692 ZNF692 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EEEDEDEEEML;EPGASPGRGAGPLASLPPRT;NWHRRKHAETAATLRFPCEFCG 3 8.9 0.87937 0.13132 0 6.97602 0 0 0 0 0 0 5.72906 8.66917 0 0 0 9.26494 0 A0A8I3N6I9 A0A8I3N6I9_CANLF Tubulin tyrosine ligase like 3 TTLL3 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737] DEALCACEEH;FPRCYRLGAEDDKKA;LDSSVMGDSDTTEDEDEDEDE;MEGDRNIWIVKPG;SDTTEDEDEDEDEAFQ;TTEDEDEDEDEAFQ;VEKKMVHHSGTTLP 7 8.7 1.002 -1.3639 9.28068 0 3.11121 0 11.2022 0 0 5.15368 0 0 8.62928 0 0 0 0 A0A8I3N6J3 A0A8I3N6J3_CANLF Protein BANP BANP Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] DNA binding [GO:0003677] DGESGSEASDSFSNCGQS;TVLSTPPP 2 5.6 0.99244 0.0049503 0 0 0 0 8.34256 0 9.66019 9.80542 0 0 0 0 2.84573 0 0 A0A8I3N6K0 A0A8I3N6K0_CANLF Talin 1 TLN1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; ruffle [GO:0001726] actin filament binding [GO:0051015]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166] AAAARAVTDSIN;ANALDDGQWSQGLISAARMVAAAT;ATTEHIRQELAVFCSPEPP;CGQMSEIEAKVRY;EAANAAVQGHASQEKL;ELMEEKKEEV;ERELEEARKKLA;HIRQELAVFCSPEPPA;LEDSVSPKKSTVLQ;LLGAAAAI;LNEAAAGLNQAA;LVLKAKSVAQRTEDSGLQ;NLSRRAIADMLRACKEAAYHPE;SPVCQEQLVEAGRLVAKAVEGCVSA 14 8.1 1.0032 -2.4016 0 9.16553 11.2063 6.94111 9.50847 8.00265 0 0 9.93525 8.30825 0 8.30939 10.3748 9.64167 0 A0A8I3N6K4 A0A8I3N6K4_CANLF ATP binding cassette subfamily B member 5 ABCB5 Canis lupus familiaris (Dog) (Canis familiaris) eye development [GO:0001654]; regulation of membrane potential [GO:0042391] plasma membrane [GO:0005886] ABC-type oligopeptide transporter activity [GO:0015421]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562] ANIHSFIED;LLRKPKILLL;LMAKQGLY;QKQRIAIARALVRKPKI;RNRKPQELPKV;VGEKGAQMSGGQ;VIHSSYCIGTAAPNF 7 6.4 1.0036 -1.6035 9.11067 5.99009 4.99408 8.76265 0 0 11.2768 5.77781 0 0 0 0 0 5.20852 0 A0A8I3N6L2 A0A8I3N6L2_CANLF Zinc finger protein 285 ZNF285 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ACDQCGKDFSQSSD;KVFRRNSSLHNHHR;REKPYKCDVCGK;VGFIDGADPP;VGFIDGADPPVHHST 5 9.3 0.98702 -0.33167 0 0 7.63742 0 0 8.07377 0 10.4694 5.75165 0 0 0 0 8.11437 0 A0A8I3N6L7 A0A8I3N6L7_CANLF General transcription factor IIH subunit 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; transcription factor TFIID complex [GO:0005669] ATPase activator activity [GO:0001671]; RNA polymerase II general transcription initiation factor activity [GO:0016251] LVFQRKRKSRRYYPTRLAINL;PAQLWYFML 2 6.5 1.0022 -0.75705 10.3491 0 0 0 0 0 0 0 6.64731 0 0 0 0 0 0 A0A8I3N6M2 A0A8I3N6M2_CANLF Olfactory receptor family 2 subfamily AG member 1C OR2AG1C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVVGMFYGAAT;VYVTGVTF 2 6 1.0021 -1.2965 0 0 0 0 0 0 0 0 0 8.01179 0 0 10.4451 0 0 A0A8I3N6M7 A0A8I3N6M7_CANLF Histone acetyltransferase (EC 2.3.1.48) KAT6A Canis lupus familiaris (Dog) (Canis familiaris) cellular senescence [GO:0090398]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytosol [GO:0005829]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleosome [GO:0000786]; PML body [GO:0016605] DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] DNMLFCDSCDRGFHMECCDP;EDLPLTEEGKEEEEMHV;EETLAACQTLQ;EIDEEEEEEDENELFSRGYFH;EIHTWYSSPYPQEYS;EMHVEAEEVEEGEEEDTTSSEV;EPDTSTPMKKKKGWPKGKSRKP;EQEEEDEVAIETNQNEDHD;ETSTPQEQYGECEE;HHSYMNAAGV;IETNQNEDHDADDEDD;ILTKPTLKRKKPILHRR;LQSYTQADEDPQMSMVEDCHASE;MELFRDIQEQ;PGDFGAGSYSQPSATFSLAKL;PILTKPTLKRKKPILHRRRRVR;PVDVDPECLRWTPV;RGYFHRLSSQ;SGFHQQLRLAIK;SSEEEEEPESP;SSYDSTMGGSICGNNSSQSSC;SVQSHPSQSVRSVSSPNVP;TQERFSDKESKLLLEE;VEPIVPIPKQ;VSLLPHEKDKPIAEPI;VSSPNVPALESG;YRLNTKATSVD 27 19 1.003 -1.3379 14.0915 14.0643 11.6392 7.52896 11.4229 10.6969 14.1153 8.21072 11.7596 0 14.0104 13.9926 14.0809 0 0 A0A8I3N6N4 A0A8I3N6N4_CANLF Prostaglandin E synthase 3 (cPGES) (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) PTGES3 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131]; prostaglandin biosynthetic process [GO:0001516]; protein folding [GO:0006457]; telomerase holoenzyme complex assembly [GO:1905323]; telomere maintenance via telomerase [GO:0007004] cytosol [GO:0005829]; nucleus [GO:0005634] Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087] FDRFSEDSQDSDD;IDPNDSKHKRTDRSILCC;KDWEDDSDEDMSN;KDWEDDSDEDMSNFDRFSEDSQD;NWKDWEDDSDEDMS 5 33.1 0.93339 0.10581 0 0 0 0 0 0 0 0 6.49376 0 0 0 0 5.97579 0 A0A8I3N6P6 A0A8I3N6P6_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2" SMARCC2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694] DSEASLGPLAYQPIPF;EIEASVEDAP;SDQGWRRYDFQNPSRMD;SRTQDECILHFLRLPIEDPYLEDS;TDTFNEWMNEE;VESEGERKTKVERDIGEGNL 6 8.6 1.0023 -0.65343 0 0 12.0568 0 0 0 0 0 0 10.9012 0 0 0 0 0 A0A8I3N6Q0 A0A8I3N6Q0_CANLF Heat shock transcription factor 2 HSF2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] CSQYPDIVIVEDDNED;LVSLKRKRPLL;SENESLWKEVSEL;SLTTEDPV 4 9.3 1.0021 -1.4524 0 12.7854 0 0 0 4.0697 0 0 13.2038 0 0 0 0 0 0 A0A8I3N6Q2 A0A8I3N6Q2_CANLF Transcription initiation factor TFIID subunit 10 TAF10 Canis lupus familiaris (Dog) (Canis familiaris) allantois development [GO:1905069]; apoptotic process [GO:0006915]; embryonic placenta development [GO:0001892]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; multicellular organism growth [GO:0035264]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756] male germ cell nucleus [GO:0001673]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251] KFISDIANDALQHC 1 6.4 0.98483 -0.24644 0 0 0 0 9.32681 0 0 0 0 0 0 0 0 0 0 A0A8I3N6S1 A0A8I3N6S1_CANLF Uncharacterized protein ZFP14 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" AEYQRVHNGEKLYE;QEGYFGQVK 2 4.6 1.0039 -1.0589 0 0 10.4899 0 0 0 0 0 0 0 0 10.5653 0 0 0 A0A8I3N6S3 A0A8I3N6S3_CANLF EMAP like 3 EML3 Canis lupus familiaris (Dog) (Canis familiaris) mitotic metaphase chromosome alignment [GO:0007080]; regulation of mitotic spindle assembly [GO:1901673] cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634] FCKVHLFQYPCA;FGAVRAIAEGPGSQLL;PGGPGGGG;RFGRCVGHSSFITHLD;SPSLGPDSRRLLR 5 6.2 1.003 -0.75578 10.7645 0 0 0 0 0 0 10.5498 0 0 0 0 9.54123 0 0 A0A8I3N6S4 A0A8I3N6S4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" EKNYEYSK;LVRKVTSISKKTLI;QNFYECDSLDK 3 5.1 0.98604 -0.41536 0 6.88947 0 0 0 0 0 0 0 0 0 0 0 0 9.37241 A0A8I3N6S5 A0A8I3N6S5_CANLF Glucosidase II alpha subunit GANAB Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] HADNLRLKVTEGGEPYRLYNLDVF;QGTAQGELFLD 2 4.1 0.94552 0.076793 0 0 0 0 0 4.76261 0 0 0 0 0 0 0 0 9.01675 A0A8I3N6T4 A0A8I3N6T4_CANLF FAM194 C-terminal domain-containing protein ERICH6B Canis lupus familiaris (Dog) (Canis familiaris) QEKKFLEENEFLLEKYLEDEFK 1 3.6 0.97684 0.047891 0 8.16506 0 0 0 0 0 0 8.98991 0 0 0 0 0 0 A0A8I3N6U1 A0A8I3N6U1_CANLF E3 ubiquitin protein ligase (EC 2.3.2.27) RNF20 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] HULC complex [GO:0033503]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H2B C-terminal K residue ubiquitin ligase activity [GO:0140850]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625] DEARTLLHGTRGTHQ;LDIRTLQTKNRKL;QNHNHQLKGEVLRYKRKL;RKREQRLNRHLAE;RRAVSQIVTVYDKLQEKVELL;TAESRVSVLESMIDDLQ;TVYDKLQEKVEL 7 9.9 0.99278 -0.16944 0 10.6327 15.0585 0 9.24517 0 7.053 2.8586 0 8.14771 0 0 0 0 0 A0A8I3N6U2 A0A8I3N6U2_CANLF LBH domain containing 1 C18H11orf98 Canis lupus familiaris (Dog) (Canis familiaris) PAAGSHVC 1 3 1.0035 -1.1044 0 0 0 0 9.7362 0 0 0 0 0 0 0 0 0 0 A0A8I3N6U7 A0A8I3N6U7_CANLF Sodium-dependent phosphate transport protein 2B (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Solute carrier family 34 member 2) SLC34A2 Canis lupus familiaris (Dog) (Canis familiaris) sodium-dependent phosphate transport [GO:0044341] plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436] EAATHYLEVL;KYTEGSPGLQ;VGVGAPVV 3 3.9 1.003 -0.88227 0 0 8.40378 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N6V5 A0A8I3N6V5_CANLF Uncharacterized protein NUDT8 Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA catabolic process [GO:0046356]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA catabolic process [GO:1902859]; succinyl-CoA catabolic process [GO:1901289] mitochondrion [GO:0005739] coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] EEHVWGVL 1 5.7 0.99672 -0.094919 0 0 0 12.0895 0 0 0 0 0 0 0 0 0 13.3946 0 A0A8I3N6V9 A0A8I3N6V9_CANLF DNA ligase (EC 6.5.1.1) LIG3 Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; zinc ion binding [GO:0008270] GKRHWLKVKKDY;GLEGLVLK;KPSPVKVG;MGCYDPSSQK;NPDDMARDLEQGDV 5 5.6 0.99022 -0.26592 0 0 0 0 0 0 0 0 7.15026 0 0 0 0 0 0 A0A8I3N6W3 A0A8I3N6W3_CANLF Terminal nucleotidyltransferase 5B (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46B) TENT5B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of translation [GO:0045727] cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) RNA polymerase activity [GO:1990817] AQWCTLTWQQGGV;LVKVCTDTDRWSL;RRQTLDLIA;TVTGESLYGDFAEALDHLRHRVI 4 15.9 1.003 -0.78958 12.864 0 0 0 0 0 0 0 8.18458 0 0 0 0 0 0 A0A8I3N6Y3 A0A8I3N6Y3_CANLF Integrator complex subunit 1 INTS1 Canis lupus familiaris (Dog) (Canis familiaris) U2 snRNA 3'-end processing [GO:0034474] integrator complex [GO:0032039] ADEQTTCEVLDYFL;ADFLPTFM;AEMAPYMKR;AVQRLEMWLQNPKLTRPAQ;HLIKIRLKPKVL;LDMEFKERFVVHITD;LEELLAALLAPAPMSPTLRPVA;LIKIRLKPKVLLNHY;LRLLTSTCGYKEVRLMAV;LTESVEEYVL;QVKEAGTAWDKGE;SQREKQEILAFEG;SVRPTTALALQQAIHM;VLSDIDEMSRRRP 14 9 1.0029 -0.79722 0 10.9559 10.4508 7.67765 0 0 0 16.2658 0 0 13.5011 0 10.3778 6.90002 0 A0A8I3N6Y4 A0A8I3N6Y4_CANLF Potassium channel tetramerization domain containing 4 KCTD4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] TLNVGGYL;VGGYLYITQKQT 2 5.8 0.98703 -0.23445 0 0 9.57499 0 10.0151 0 11.9103 0 0 10.4332 0 0 0 0 0 A0A8I3N6Z4 A0A8I3N6Z4_CANLF Glutamyl-tRNA amidotransferase subunit B GATB Canis lupus familiaris (Dog) (Canis familiaris) glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] LVSFFDASLPGTLPN 1 13 0.99344 -0.071223 0 0 0 0 0 0 0 0 0 8.96235 0 0 0 0 0 A0A8I3N702 A0A8I3N702_CANLF MAPK regulated corepressor interacting protein 1 MCRIP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic stress granule [GO:0010494] MTRWVSGSGATSPGG 1 7.1 0.99391 -0.12709 0 0 0 0 0 0 0 0 0 10.0386 0 0 0 0 0 A0A8I3N732 A0A8I3N732_CANLF Pannexin PANX2 PANX Canis lupus familiaris (Dog) (Canis familiaris) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732] gap junction [GO:0005921]; plasma membrane [GO:0005886] channel activity [GO:0015267] AEPEGTAEPPVVKRPRKKMK;GGGGDPGPVPDKKHARHFSLDV;GVDASLWPSLFEHKL;KLLPYSLLAF;KYLERRGRSNFLAKL;PLSPASLG;VPILLVTLVFTKNFAEE 7 16.5 1.0043 -1.1044 0 0 8.29122 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N733 A0A8I3N733_CANLF Regulator of G protein signaling 7 binding protein RGS7BP Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; regulation of postsynaptic membrane potential [GO:0060078] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] LVRRRKRRFFGL;RALDDCKMLVQEFNTQ;TMPLPLKN 3 14 0.99405 -0.16353 0 0 0 0 0 0 9.35522 7.59268 0 0 0 6.63393 0 0 0 A0A8I3N734 A0A8I3N734_CANLF Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052] cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686] DPEINTKKINPENSKLSD 1 5.4 0.97025 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 9.37827 0 A0A8I3N745 A0A8I3N745_CANLF TATA element modulatory factor 1 TMF1 Canis lupus familiaris (Dog) (Canis familiaris) LVPIIVNPSTP;NSNIIKKLRAKDK;PVSGGWDT;SFAKQALSQAQK 4 4.5 1.0034 -1.9642 0 0 0 0 0 10.3255 8.49229 0 0 0 0 0 0 11.3054 0 A0A8I3N748 A0A8I3N748_CANLF Zinc finger protein 454 ZNF454 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AFECSECGKVFTKSSTLNK;PKVDIPDQDD 2 5.7 0.99252 -0.1715 0 0 0 0 0 0 6.29407 0 0 0 0 0 0 0 0 A0A8I3N762 A0A8I3N762_CANLF C2HC/C3H-type domain-containing protein LOC474655 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] HSSLLPETE;VVCYICGREYGTK 2 4.8 0.99232 -0.18426 0 0 0 0 0 0 10.8558 0 0 0 0 0 0 0 0 A0A8I3N778 A0A8I3N778_CANLF Olfactory receptor family 52 subfamily W member 1 OR52W1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] CSSHICVILAFYVP 1 4.4 0.94051 0.060971 0 0 0 10.2905 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N782 A0A8I3N782_CANLF U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) PRPF31 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal tri-snRNP complex assembly [GO:0000244] precatalytic spliceosome [GO:0071011]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540] RNA binding [GO:0003723] GYIYHSDIVQS;IVDANNLTVE;TVKELGNSLDKCKNNENL;YVESRMSFI 4 9.7 0.98787 -0.48598 0 0 0 0 7.32202 6.29576 7.46915 0 0 7.94216 7.55198 0 0 0 0 A0A8I3N789 A0A8I3N789_CANLF Biogenesis of lysosomal organelles complex 1 subunit 4 BLOC1S4 Canis lupus familiaris (Dog) (Canis familiaris) anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; platelet aggregation [GO:0070527] axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083] GDSGNVSQSHSSASGPWEDEGP 1 10.1 0.97692 0.047387 6.24216 7.0398 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N791 A0A8I3N791_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LHLDFLKRLP 1 8 0.99123 -0.27431 0 0 0 0 0 0 11.2718 0 0 0 0 0 0 9.96881 0 A0A8I3N795 A0A8I3N795_CANLF Kinesin-like protein KIFC2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EVQLQGLRGALRQLQQET;SLSEARGQVSWALGALSA 2 4.6 0.93188 0.10715 0 10.4095 0 0 0 0 0 0 0 0 0 0 5.09698 0 0 A0A8I3N7A6 A0A8I3N7A6_CANLF Coiled-coil domain containing 178 CCDC178 Canis lupus familiaris (Dog) (Canis familiaris) EANAKLQADIDYMNKHGPLIN;ESEIQSLMKLR;HSDEKRSI 3 5 1.0029 -1.1044 0 0 0 0 0 8.78966 0 0 0 0 0 0 0 0 0 A0A8I3N7B0 A0A8I3N7B0_CANLF NFIL3 like basic leucine zipper NFILZ Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EPLPSLHGSH;LLEENALL;YHLLDGHGGARPELRPFWGLW 3 13.5 0.99663 -0.59154 0 9.51033 0 0 0 9.85223 0 8.56362 0 0 0 0 0 0 0 A0A8I3N7B8 A0A8I3N7B8_CANLF Histone deacetylase (EC 3.5.1.98) HDAC5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872] EEEEEEEEEEEECIQ;EEEEEEEEEEEEEEEEECIQ;HLFTTGPISQKMY;QEDLEEEEEEEEEEEEEEEEECIQV;QLVMQQQHQQF;QRQQEQRRQEEL;SAVRMAVGCLVELAF;VTARCFGH 8 8.1 0.93713 0.05984 0 0 0 0 0 0 0 0 0 0 0 0 8.73285 0 0 A0A8I3N7B9 A0A8I3N7B9_CANLF Angiopoietin like 1 ANGPTL1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] EQCLKIFSRQ;WWYNACAH 2 3.7 0.98509 -0.24528 0 0 0 0 10.5783 0 0 0 0 0 0 0 0 0 0 A0A8I3N7D1 A0A8I3N7D1_CANLF Fer-1 like family member 6 FER1L6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] DLESEFNNFEDW;FGLKLKKRKK;ILIILIIFLVLFIYTLPGAI;IPSAPPKRRSKLLTKI;KCLYHLIWKNYKKYIIIGFILIIL;KKGMFGLKLKKRKKK;LKLKKRKKKA;PSAPPKRRSKLL 8 4.9 1.0006 -0.92887 3.10524 0 0 0 5.31915 0 5.8883 9.13922 0 0 0 8.20643 0 6.78594 0 A0A8I3N7E8 A0A8I3N7E8_CANLF Golgi associated kinase 1B GASK1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EWSKLALFDFLL;LHSSWSQAWGQLYGR 2 11 0.98935 -0.21704 0 0 9.66583 5.62904 0 0 0 0 0 0 0 4.47871 0 0 0 A0A8I3N7F0 A0A8I3N7F0_CANLF Uncharacterized protein LOC119865621 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CRLHSGEKLYKCKGCG;QTSPKAEPHEELS;YQGNGCKEFFSDTSNC 3 9.5 0.85528 0.1583 0 6.74187 0 0 0 0 0 0 6.55382 0 0 0 0 0 8.71174 A0A8I3N7F1 A0A8I3N7F1_CANLF Zinc finger protein 879 ZNF879 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AAGPGAFP;IRKPRLITRGRKPHSQH;KNLNLKPSLIRKPRLITRGRK;PGGLAAAA;QRMLYREVMLE 5 8.2 1.0032 -0.97551 0 9.45065 0 0 3.39506 0 0 0 6.06458 0 0 9.10609 0 3.13973 0 A0A8I3N7G9 A0A8I3N7G9_CANLF Kv channel-interacting protein 4 KCNIP4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] cytoplasm [GO:0005737]; voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459] KMDKNKDGVVTIDEFIE;VIVLFVKLLEQFG 2 13.1 0.93792 0.059573 0 0 0 0 0 0 0 7.7224 0 0 0 0 0 0 0 A0A8I3N7H1 A0A8I3N7H1_CANLF Uncharacterized protein C10H2orf73 Canis lupus familiaris (Dog) (Canis familiaris) DVREAAKACPRSP;TATLFQAKTGRAS 2 5.7 0.98898 -0.52404 0 0 0 0 0 0 11.4447 0 0 0 0 0 12.4773 0 0 A0A8I3N7I0 A0A8I3N7I0_CANLF "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52)" IDO1 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441] cytosol [GO:0005829] "heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" AAASAIKVIPNLLKAVKNQ;LSGWKGNSKLPEGLKYEG;MESPQRIFEKYHID 3 12.5 0.98955 -0.21581 0 0 0 0 0 4.95573 0 0 0 4.60875 0 0 0 6.67709 0 A0A8I3N7I5 A0A8I3N7I5_CANLF Family with sequence similarity 170 member A LOC102151165 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] DILLSGPSGL;LRQKVNPLNQYI;QENVPQPESYVVSPG;YVVSPGSEI 4 9.7 0.99064 -0.27477 0 0 0 0 0 0 0 9.51078 0 0 0 0 0 0 0 A0A8I3N7I7 A0A8I3N7I7_CANLF Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) ATXN7L3 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of transcription by RNA polymerase II [GO:0006357] DUBm complex [GO:0071819]; SAGA complex [GO:0000124] nuclear receptor coactivator activity [GO:0030374]; zinc ion binding [GO:0008270] EDNDDINDNDWSYGSE;FNQWKSKECVCPNCS;GELSNSDPF;LGPSAILPEVE 4 14.4 1.0023 -0.6656 0 6.94427 11.1639 0 0 0 0 0 8.74839 0 0 0 0 0 0 A0A8I3N7J3 A0A8I3N7J3_CANLF Male-enhanced antigen 1 MEA1 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] cytoplasm [GO:0005737] DVVADIQDRIQ;GAPARMAAVVLGGDT;MAAVVLGG 3 13.9 0.99247 -0.17653 0 0 0 0 0 3.49185 0 0 0 0 0 0 14.3961 0 0 A0A8I3N7K8 A0A8I3N7K8_CANLF Testis anion transporter 1 (Solute carrier family 26 member 8) SLC26A8 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; inorganic anion transmembrane transport [GO:0098661]; meiotic cell cycle [GO:0051321]; spermatogenesis [GO:0007283] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] CQCFCNCDE;FVDSRASVSLRQNEE;LEPEPELG;QNYEDMDKAW;SQSISDDQGPYT;TIFPFLEWVCLYRFKDW 7 9.5 1.0032 -2.3594 0 0 0 5.52532 9.15884 6.54716 0 0 5.89947 0 0 0 7.87492 9.96607 0 A0A8I3N7K9 A0A8I3N7K9_CANLF Cyclic nucleotide gated channel subunit alpha 4 CNGA4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886] cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] VRFHTDHALVKKYMKQQHVNRRLER 1 11.4 0.99007 -0.29861 0 0 0 0 0 0 9.00579 0 0 0 0 0 0 0 0 A0A8I3N7N5 A0A8I3N7N5_CANLF KIAA0232 KIAA0232 Canis lupus familiaris (Dog) (Canis familiaris) DKENTFILGGVYGELKTFS;EAETLREPH;ESTQFNTE;ETMWCSRKVRDLWWQ;FHPRICGVDRTQY;IETLVEELCSRLKDL;KSILCSDSDSEVFHPRIC;YLDDIHLSELTHFYE;YRLWEGQKDSLEKRAF 9 6.1 1.0034 -1.6711 0 4.18587 8.29122 9.49153 5.59711 10.8971 0 12.1647 0 0 0 0 9.7699 0 0 A0A8I3N7N9 A0A8I3N7N9_CANLF Zinc finger protein 346 ZNF346 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] double-stranded RNA binding [GO:0003725]; zinc ion binding [GO:0008270] RLWEAVSGAQPVGREEVEHMI 1 8 0.97655 0.047981 0 0 0 0 0 0 9.47003 0 0 0 0 0 0 0 0 A0A8I3N7P4 A0A8I3N7P4_CANLF Protein transport protein sec16 SEC16B Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; peroxisome fission [GO:0016559]; positive regulation of gene expression [GO:0010628]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; protein transport [GO:0015031] endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] AAVVTPGG;FQHPDGQKV;HPQQLQEERVPRRESPYIWQEDHR;LVELIKLAEKLKLSDPL;VAHVPFGHYTVKTDH;VTGDAADP 6 7.7 1.0033 -1.6923 9.65789 0 10.3582 7.27482 4.74653 8.98556 7.16621 0 0 9.96525 0 0 0 11.9583 11.901 A0A8I3N7P5 A0A8I3N7P5_CANLF Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) MAP3K7 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; immune response [GO:0006955]; JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709] GEMIEAPSQVLNFEEI;GVAYLHSMQ;QYPCQYSD;THLMRYFPGADEPLQYPCQYSDEGQ;TLDHQLQARTSCR 5 12.2 1.0034 -2.0546 10.1211 0 7.97068 0 0 7.24117 0 7.60689 0 0 0 0 0 0 0 A0A8I3N7Q1 A0A8I3N7Q1_CANLF Family with sequence similarity 135 member B FAM135B Canis lupus familiaris (Dog) (Canis familiaris) cellular lipid metabolic process [GO:0044255] MLNNPEKIAEQ;NVDLFQRGYYQI;PGAGTDSFPGQVV;QVTTYLTQ;SVISVTIHAALV 5 4 1.0041 -1.1 0 8.72281 0 13.0565 0 0 13.4757 0 13.4538 0 0 0 13.9929 0 0 A0A8I3N7Q2 A0A8I3N7Q2_CANLF SUI1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation initiation factor activity [GO:0003743] KKKLVKVFKKK;KKLVKVFKKK 2 9.7 0.9969 -0.57597 0 0 6.60447 0 4.56224 0 0 0 0 0 0 0 0 0 0 A0A8I3N7Q4 A0A8I3N7Q4_CANLF Interleukin-23 subunit alpha (Interleukin-23 subunit p19) IL23A Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771] interleukin-23 complex [GO:0070743] cytokine activity [GO:0005125]; interleukin-23 receptor binding [GO:0045519] LLLLLLLL;LLLLLLLLP;LLLLLLLP;LLRLKILRSLQ;QAFVAVAARV 5 15 0.99305 -0.28303 0 0 0 0 0 7.96734 0 7.50914 0 0 0 0 0 0 0 A0A8I3N7Q9 A0A8I3N7Q9_CANLF L-xylulose reductase (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) DCXR Canis lupus familiaris (Dog) (Canis familiaris) D-xylose metabolic process [GO:0042732]; glucose metabolic process [GO:0006006]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; NADP metabolic process [GO:0006739]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; xylulose metabolic process [GO:0005997] brush border [GO:0005903]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microvillus [GO:0005902] "identical protein binding [GO:0042802]; L-xylulose reductase (NADPH) activity [GO:0050038]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]" SSMTTGSA;VGPVDLLV 2 6.6 0.98965 -0.5305 0 0 0 0 0 0 0 0 0 0 0 0 8.74012 13.9466 0 A0A8I3N7R4 A0A8I3N7R4_CANLF Coiled-coil domain-containing protein 89 CCDC89 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] EMEFKELDGLRE;LQARLQTVTREKDELLQ 2 7.8 0.93121 0.096667 0 0 0 0 9.7604 0 0 0 0 0 0 0 0 0 5.99277 A0A8I3N7R6 A0A8I3N7R6_CANLF Transcriptional adapter 3 (ADA3 homolog) (Transcriptional adapter 3-like) TADA3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; SAGA complex [GO:0000124] transcription coactivator activity [GO:0003713] LGKHYSQRWAQEDLLEEQKDGARA 1 5.6 0.992 -0.066044 0 0 0 0 0 0 0 0 0 0 0 0 0 17.0245 0 A0A8I3N7R9 A0A8I3N7R9_CANLF Angiopoietin like 2 ANGPTL2 Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] GGHYRSRYQDGV;GGWTVIQRRLDGSVNFFRNWETYK;RYKRASESSDKCTYTFIVPQQRVT;WWYNACAH 4 13.8 0.99186 -0.18296 7.83384 0 0 0 0 7.48696 0 0 0 0 9.39746 0 0 0 0 A0A8I3N7T3 A0A8I3N7T3_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC18 Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to membrane [GO:0006612] endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139] protein-cysteine S-palmitoyltransferase activity [GO:0019706] CSVCDNCVERFDHHCPWVG;CVGRRNYRFFYAFI;SPPKFISPLLK 3 10.6 0.98184 0.035491 0 0 0 0 0 0 0 3.02749 0 0 0 0 0 0 0 A0A8I3N7U2 A0A8I3N7U2_CANLF Prostate androgen-regulated mucin-like protein 1 C18H11orf24 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSSGGSKM;VTLFIIILVL 2 4.6 1.0031 -1.7158 0 0 0 0 0 0 0 0 0 0 0 8.61243 8.12738 0 0 A0A8I3N7V5 A0A8I3N7V5_CANLF Transmembrane 6 superfamily member 1 TM6SF1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] GVAALILLLVALLARVLVKRG;GVAALILLLVALLARVLVKRGKP;LILLLVALLARVLVK;LPQLLAYR;PYLNTAYGHMI;VAALILLLVALLARVLVK;VGVAALILLLVALLAR;VGVAALILLLVALLARVLVKRGKP;VPGNIVGK 9 15 0.86683 0.13472 0 0 5.2407 0 0 0 0 0 0 0 0 0 7.43505 0 0 A0A8I3N7V9 A0A8I3N7V9_CANLF Rac family small GTPase 3 RAC3 Canis lupus familiaris (Dog) (Canis familiaris) "cell projection assembly [GO:0030031]; cerebral cortex GABAergic interneuron development [GO:0021894]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; homeostasis of number of cells within a tissue [GO:0048873]; motor neuron axon guidance [GO:0008045]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of neuron maturation [GO:0014041]; small GTPase-mediated signal transduction [GO:0007264]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway [GO:0016055]" cell periphery [GO:0071944]; cytoplasmic vesicle [GO:0031410]; endomembrane system [GO:0012505]; filamentous actin [GO:0031941]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471] calcium-dependent protein binding [GO:0048306]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] TIERLRDKKLAPI 1 6.8 0.94045 0.059615 0 0 6.56078 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N7W6 A0A8I3N7W6_CANLF Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) MED22 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] core mediator complex [GO:0070847]; mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] DLKQFLILNDFPSVNEAIDQRNQ 1 11.5 0.974 0.04661 0 0 0 10.1032 0 0 0 0 10.1582 0 0 0 0 0 13.7177 A0A8I3N7W8 A0A8I3N7W8_CANLF Leucine rich repeat containing 63 LRRC63 Canis lupus familiaris (Dog) (Canis familiaris) DISHFPTEVFCLKNLQ 1 8.7 0.93454 0.065248 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9289 0 A0A8I3N7X1 A0A8I3N7X1_CANLF Transmembrane epididymal protein 1 LOC100687029 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DISDIMFV;PQRCVLLEKGSLVLTFYVLLL;PRNKGRWARLWKI 3 14 0.99159 -0.27263 0 0 7.47622 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N7X3 A0A8I3N7X3_CANLF PR domain zinc finger protein 4 (PR domain-containing protein 4) PRDM4 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] DNA binding [GO:0003677]; histone methyltransferase binding [GO:1990226]; methyltransferase activity [GO:0008168] ADTVGHGG;LADRPPPQY;TQKAHLESHMV;VCEKCTKAYLTKYHLTRHL 4 6.4 1.0034 -1.5471 0 9.29868 0 0 0 0 0 0 0 0 7.97304 0 10.3258 0 0 A0A8I3N7X6 A0A8I3N7X6_CANLF Chromosome 13 C8orf76 homolog C13H8orf76 Canis lupus familiaris (Dog) (Canis familiaris) DKMKGFSFKEDTLLLIAEVMGEDIV 1 7.2 0.99217 -0.29496 0 0 0 0 0 0 0 0 9.86896 0 0 0 0 0 0 A0A8I3N7Y0 A0A8I3N7Y0_CANLF Uncharacterized protein LOC100687115 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DISDIMFV;LLKLVTGSILTVY;LLLLISHV;LVLTFYVLLLLLIS;PQRCVLLEKGSLVLTFYVLLL;YVLLLLLI 6 17.6 0.99893 -2.9354 0 7.93587 8.29637 3.65455 4.9813 0 0 0 0 0 9.56199 0 0 0 0 A0A8I3N7Y2 A0A8I3N7Y2_CANLF Chromodomain helicase DNA binding protein 1 like CHD1L Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] EELEDRRKKRQEAAAK;GAGRSGGD;LMKDLDAFESEMA;LSFVEPDLFPKEQVG;QSFCLPSEESEPED;YSLLSFVE 6 9.2 1.0023 -1.3914 0 0 0 0 0 0 0 0 10.4468 13.4756 9.35768 0 9.68557 0 0 A0A8I3N7Y5 A0A8I3N7Y5_CANLF Protein lin-7 homolog LIN7A Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; inner ear development [GO:0048839]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031]; synaptic vesicle transport [GO:0048489] basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; MPP7-DLG1-LIN7 complex [GO:0097025]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793] L27 domain binding [GO:0097016] VHKLQSLKKVLQSEF 1 6.4 0.95115 0.053889 0 0 0 0 0 0 0 8.64537 0 0 0 0 0 0 0 A0A8I3N7Z6 A0A8I3N7Z6_CANLF DnaJ heat shock protein family (Hsp40) member C1 DNAJC1 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] protein-folding chaperone binding [GO:0051087] FYQFLGVQQDASS;KKVKVKKPKPEFP;LAAVGPAH;LDELLSRKKREKKKKTGSK;LSRKKREKKKK;PESRPRRRRPT;PPLLLLLL;PPLLLLLLL;PVYTPLESAYIQSYDHGTSI;WRRLVRFPPPPPLLLLLLLAAV 10 18 1.0034 -1.6994 0 0 6.55189 0 0 0 0 12.3538 5.31843 0 0 9.66279 0 0 0 A0A8I3N800 A0A8I3N800_CANLF Zinc finger protein 35 ZNF35 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] SLTVHQRTHTGEKPYE 1 3 0.95187 0.053293 0 0 0 0 0 0 6.85437 0 0 0 0 0 0 0 0 A0A8I3N821 A0A8I3N821_CANLF Immediate early response 3 IER3 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of glycolytic process [GO:0045820]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of protein catabolic process [GO:0045732]; regulation of DNA repair [GO:0006282]; regulation of nucleocytoplasmic transport [GO:0046822]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to protozoan [GO:0001562] mitochondrion [GO:0005739]; nucleus [GO:0005634] SGPEIFTF 1 5.1 1.0031 -1.1044 0 0 0 0 0 0 0 0 0 0 8.29902 0 0 0 0 A0A8I3N829 A0A8I3N829_CANLF Cellular communication network factor 4 CCN4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; signal transduction [GO:0007165] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] heparin binding [GO:0008201]; integrin binding [GO:0005178] DGCECCKMC;GVCTDDRCCIPY 2 7.6 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 5.09972 0 0 A0A8I3N849 A0A8I3N849_CANLF Disintegrin and metalloproteinase domain-containing protein 20-like LOC119872887 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DMGFDCDVSTCNF;IFSIHQTLLLLIIRLSLFLISGI;IVVTGINQEKCFGYDAHHGTEIPE;VRGGGKPVRCEEDDVL 4 10.3 0.97833 0.046253 0 0 0 0 0 0 0 5.61344 0 0 0 0 0 0 0 A0A8I3N852 A0A8I3N852_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LWSSKKLTMKVI 1 19 0.95266 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 3.8127 0 A0A8I3N856 A0A8I3N856_CANLF Cholinephosphotransferase 1 (EC 2.7.8.2) (Diacylglycerol cholinephosphotransferase 1) CHPT1 Canis lupus familiaris (Dog) (Canis familiaris) platelet activating factor biosynthetic process [GO:0006663] Golgi membrane [GO:0000139] diacylglycerol cholinephosphotransferase activity [GO:0004142]; metal ion binding [GO:0046872] RLEEHRYCAAGVSLLEPPLQVYWTW;TIPILEIKL;VGGAIFSC;YFHVILHGGVGKNGSTIA 4 15.1 1.0021 -1.431 0 4.33685 9.0587 0 0 0 5.91939 0 0 0 0 0 9.91974 0 9.91234 A0A8I3N858 A0A8I3N858_CANLF Vav guanine nucleotide exchange factor 3 VAV3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] DETHVDDEEGLYDCVYGE;EDIYKGLPD;EYAISIKYNN;INYKERLVIYGQYCS 4 6.5 1.002 -1.3051 0 0 0 0 5.5022 5.96495 0 0 0 3.18209 12.464 0 0 0 0 A0A8I3N859 A0A8I3N859_CANLF Activator of HSP90 ATPase activity 1 AHSA1 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] cytosol [GO:0005829] ATPase activator activity [GO:0001671]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087] DEPDTNLV;NKLDGEASINNRKGKLIFF;QELVQAFTHAPAML;SPEELYRVFTTQEL 4 15.4 1.0014 -0.6411 0 0 7.96798 0 0 0 0 10.8989 0 0 0 0 8.12479 0 0 A0A8I3N871 A0A8I3N871_CANLF RNA polymerase I and III subunit C POLR1C Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase I activity [GO:0001054]; RNA polymerase III activity [GO:0001056] LKKVVRLARVR;RFEKNFRVDVVHMDE 2 8.8 0.93904 0.08938 0 0 0 0 9.10203 0 0 0 0 0 0 4.4802 0 0 0 A0A8I3N877 A0A8I3N877_CANLF AT-hook transcription factor AKNA Canis lupus familiaris (Dog) (Canis familiaris) epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727] centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; microtubule [GO:0005874]; nucleoplasm [GO:0005654] EELKDRMEQKQPEP;IVPLSWLPQ;PELLDDFRLAQQRLQPL;QEEVSRLRLRLEDSL;SLGLCVSHGNVELSATSSEVEDR;SPESSIVPLSW;SSPETDGPDSAPSGP;SVKPAGFHASAA;TQDQPSAA;TRTSPKPLPS 10 8.9 1.0029 -2.4895 7.59805 8.29503 9.09577 12.3179 0 0 10.2144 6.6939 0 0 9.35683 0 13.8062 9.32971 0 A0A8I3N885 A0A8I3N885_CANLF Kinesin-like protein KIF3A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231] cilium [GO:0005929]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EDDEEGEVGEDGE;EQLRKELEEKEQERLDIEEK;IPQDYQEMIENYVHWNEDIG;ISGSEEEDDEEGEV;NSKTMMCANIGPADYNYDET;SDISGSEEEDDEE;SEKPESCDNVKVVV 7 13.6 0.59804 0.38954 0 0 0 0 5.25784 0 0 0 6.70487 6.69293 7.72117 0 0 0 9.93043 A0A8I3N886 A0A8I3N886_CANLF Mucin-21 MUC21 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GSSTTSDKTGTAAKTGASVTS;SSTTSDKTG 2 4.7 1.0026 -0.75442 0 8.01631 9.82407 0 0 0 8.84599 0 8.72938 0 0 0 7.6565 0 7.7866 A0A8I3N890 A0A8I3N890_CANLF Olfactory receptor OR13C2B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVATTLFILTPLLLIIISYSLI;PMMNPLIYSLRNKDVKEAVKH 2 13.7 0.93464 0.093947 0 0 0 0 7.87338 0 0 0 0 0 5.0447 0 0 0 0 A0A8I3N891 A0A8I3N891_CANLF Uncharacterized protein IGSF23 Canis lupus familiaris (Dog) (Canis familiaris) GVSLLTFPYNIDG 1 5.5 0.98223 -0.25108 0 0 0 0 0 0 0 0 0 0 0 0 9.01633 0 0 A0A8I3N8A8 A0A8I3N8A8_CANLF Centromere protein L CENPL Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] VLWTGWFCCIF 1 3.2 0.99204 -0.18467 0 0 0 0 10.0844 0 0 0 0 0 0 0 0 0 0 A0A8I3N8B4 A0A8I3N8B4_CANLF Bromodomain containing 1 BRD1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SLIDEDAVCCICMDGE;SWVAPLEGE;VAEPASDVNRRTS;VEYDMDEED 4 4.6 0.99341 -0.15157 0 0 8.34629 3.73379 0 0 0 0 0 0 9.43434 0 0 0 0 A0A8I3N8B5 A0A8I3N8B5_CANLF Leucine rich repeat containing 73 LRRC73 Canis lupus familiaris (Dog) (Canis familiaris) CRLCDRDFGRICRALAG;HQRSSSSWMCPSDPSSQMVLMTSGL;MVENYPTALRS;VAGGAGDT 4 19.3 1.002 -1.427 7.81941 0 0 0 0 0 0 0 0 0 10.9528 6.16688 0 0 10.5769 A0A8I3N8D2 A0A8I3N8D2_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DVKRAPDWVLV;KTRVKVTWL 2 13.7 0.99133 -0.51339 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0759 A0A8I3N8F5 A0A8I3N8F5_CANLF Leucine rich repeat containing 36 LRRC36 Canis lupus familiaris (Dog) (Canis familiaris) GIQYLCSLQELN;GSEPLSSDLGSLHGLPGN;HTYDDLLRKNQQ;VSDLTPAHGS 4 6.9 1.0016 -0.75063 0 0 0 0 0 12.2695 0 9.39118 0 0 0 0 0 0 0 A0A8I3N8F9 A0A8I3N8F9_CANLF DnaJ homolog subfamily C member 3 DNAJC3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cold [GO:0070417]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; proteolysis involved in protein catabolic process [GO:0051603]; response to unfolded protein [GO:0006986] cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788] misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087] NGKLSQTNDVTIYEQL;VMKTEPTVSEYTIRSK 2 6 0.99563 -0.085166 0 0 0 0 0 0 0 11.2088 0 0 0 0 0 0 10.516 A0A8I3N8G3 A0A8I3N8G3_CANLF Homeobox protein HOXB9 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; cell chemotaxis [GO:0060326]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; mammary gland development [GO:0030879]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954] nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SERQVKIWFQNRRMKMK 1 6.8 0.983 0.046227 9.94555 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N8G7 A0A8I3N8G7_CANLF Family with sequence similarity 170 member A LOC119876795 Canis lupus familiaris (Dog) (Canis familiaris) fertilization [GO:0009566] nucleus [GO:0005634] DILLSGPSGL;ISKSSKFDPPTGPSLE 2 5.9 0.65714 0.32253 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8254 0 A0A8I3N8H8 A0A8I3N8H8_CANLF Serine palmitoyltransferase long chain base subunit 2 SPTLC2 Canis lupus familiaris (Dog) (Canis familiaris) adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] serine palmitoyltransferase complex [GO:0017059] pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758] VEQIVTSMKC;VEQIVTSMKCIMGQDGTTLG 2 3.6 0.99252 -0.144 0 0 0 0 0 0 0 0 8.67716 0 0 0 0 0 0 A0A8I3N8I4 A0A8I3N8I4_CANLF Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) MAP3K8 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] MRLLIEAALE 1 2.1 0.98987 -0.20269 8.41414 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N8J3 A0A8I3N8J3_CANLF Mitochondrial ribosomal protein L13 MRPL13 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] PVAIVKLAIYGMLPKNLHRR 1 11.6 0.97329 0.048206 0 0 0 0 0 0 0 8.4458 0 0 0 0 0 0 0 A0A8I3N8K1 A0A8I3N8K1_CANLF Insulin-like growth factor-binding protein 3 IGFBP3 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; MAPK cascade [GO:0000165]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; osteoblast differentiation [GO:0001649]; positive regulation of apoptotic process [GO:0043065]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast differentiation [GO:0045663]; regulation of cell growth [GO:0001558]; regulation of glucose metabolic process [GO:0010906]; type B pancreatic cell proliferation [GO:0044342] insulin-like growth factor ternary complex [GO:0042567]; nucleus [GO:0005634] fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; protein tyrosine phosphatase activator activity [GO:0008160] GCCLTCALREGQPCG 1 5.2 0.95698 0.053877 0 0 0 0 0 0 0 0 0 0 0 0 7.00518 0 0 A0A8I3N8L6 A0A8I3N8L6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] AEGCFCPDGHTL;ATLPSSPRTTQRVPTSTTQTFPS;CHFYAICNQHCDI;CQDCMCHPGSMSVQC;DPCDFYFECECSCRGWGDSH;EAQAMEHQCTCC;ENDPCDFYFECECSCR;FCCSHDHCEQP;GLICRNQD;GLVCRNQEQVGLFKMCYNY;GPSSPATSHRLTVS;GVSGGEFE;GVTTSTTQTGPSSSGT;LETLVTATTEATSS;LPEGLVCRNQDQDDWLKMCLNY;SAPTTPTSTPC;SENDPCDFYFECECSCRGW;SSPWSTVRLSTASSLSPE;TAASSTGI;TTQGVTVSTTQTG;TTSCQPQCEWTDWFDV;TWTDWFDEDYPV;VGLFKMCYNYRIRV;YFECECSCRGWGDSHYTT 24 8.6 0.98629 -0.24591 0 0 0 0 8.92484 0 0 0 0 0 0 0 0 0 0 A0A8I3N8M2 A0A8I3N8M2_CANLF Transmembrane protein 208 TMEM208 Canis lupus familiaris (Dog) (Canis familiaris) vacuolar protein processing [GO:0006624] endoplasmic reticulum membrane [GO:0005789]; vacuole [GO:0005773] PKGKVGTRG;SLAVYGASYH 2 13.6 1.0033 -0.87707 13.0263 0 12.8507 0 0 0 0 0 9.26973 0 13.0212 13.0174 0 0 0 A0A8I3N8M5 A0A8I3N8M5_CANLF Transmembrane protein 126A TMEM126A Canis lupus familiaris (Dog) (Canis familiaris) optic nerve development [GO:0021554]; toll-like receptor 4 signaling pathway [GO:0034142] mitochondrion [GO:0005739]; plasma membrane [GO:0005886] TYWTRISKPVFRKM 1 7.1 0.93231 0.060769 0 0 0 0 7.9818 0 0 0 0 0 0 0 0 0 0 A0A8I3N8M6 A0A8I3N8M6_CANLF Hepatic and glial cell adhesion molecule HEPACAM Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104] axon [GO:0030424]; cell-cell junction [GO:0005911]; membrane [GO:0016020] INLTVDVPISRPQVLVA 1 4.1 0.98581 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 8.29126 0 0 A0A8I3N8N2 A0A8I3N8N2_CANLF "Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)" LOC119863903 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial respirasome assembly [GO:0097250]; regulation of oxidative phosphorylation [GO:0002082]" mitochondrial respiratory chain complex IV [GO:0005751] AVASFPKKQ 1 17 0.98301 -0.25212 0 0 0 0 0 9.77624 0 0 0 0 0 0 0 0 0 A0A8I3N8P3 A0A8I3N8P3_CANLF Spectrin beta chain SPTBN1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693] membrane [GO:0016020]; spectrin [GO:0008091] actin binding [GO:0003779]; structural constituent of cytoskeleton [GO:0005200] ADEREAVQK;DAQYMFLRQ;EDRWEWLR;ILEQAVEDYAE;LEDLEVIQHRFE;LEVLLFTI;LLIKKNQTLQKEIQGHQPRIDD;NELHKMWENRQSLLSQSHA 8 4.6 1.0022 -1.2387 0 11.2161 0 7.11614 0 0 0 14.2001 0 0 0 0 0 0 0 A0A8I3N8Q6 A0A8I3N8Q6_CANLF Integrin subunit alpha M ITGAM Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EERPPLLSDFLMELKK;KYGDPLDYKDVI;LFDNSKFAPLPGQ;PVLRLEVTMEF;QDFNVTLT 5 5.8 1.0018 -0.90934 0 0 0 6.43751 0 8.24446 0 10.1127 0 0 11.5112 0 0 10.3234 0 A0A8I3N8S2 A0A8I3N8S2_CANLF Olfactory receptor OR2W3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DLGFTTSS;PMYFFLTHLS 2 5.7 0.98565 -0.25842 0 0 0 0 0 0 0 0 0 8.74779 0 0 0 0 0 A0A8I3N8S5 A0A8I3N8S5_CANLF Mitochondrial glutathione transporter SLC25A40 (Solute carrier family 25 member 40) SLC25A40 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte development [GO:0048821]; mitochondrial transmembrane transport [GO:1990542] mitochondrial inner membrane [GO:0005743] AVPATVIYFTCYD;FAGLFTGL;LIKIAPACA;PPTLVMAVPATVIYFTCYDQLSA;VTPLDVVKIRLQAQ;VYSNGLMDHL 6 18.9 1.0032 -1.6186 0 0 0 0 0 0 11.8147 14.8841 12.94 0 0 8.74846 0 0 9.89163 A0A8I3N8T3 A0A8I3N8T3_CANLF Pre-mRNA-splicing factor 38B PRPF38B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" precatalytic spliceosome [GO:0071011] GVYVRLRVLL;HLVPRGSWRKRSRSVAAGSPSA 2 12.6 1.0034 -0.87675 0 0 0 9.8489 0 0 0 0 0 4.67039 0 0 11.5472 0 0 A0A8I3N8T8 A0A8I3N8T8_CANLF Retinoic acid receptor alpha RARA Canis lupus familiaris (Dog) (Canis familiaris) cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CIIKTVEFAKQL;LPRIYKPCFVCQD;PEKGLPAP;SSEQRVSLDIDLW;VYVRKRRP 5 11.8 1.0042 -2.0198 10.815 10.9014 10.8759 0 0 7.42853 11.3562 10.438 10.1544 0 9.12366 9.55727 11.4032 0 11.3824 A0A8I3N8U9 A0A8I3N8U9_CANLF Olfactory receptor OR8B3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ITVPSFTI 1 2.5 1.0042 -1.1044 5.99071 0 0 0 0 0 0 6.04752 0 0 0 0 0 0 0 A0A8I3N8V0 A0A8I3N8V0_CANLF Leucine-rich repeat-containing protein 14 LRRC14 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of toll-like receptor signaling pathway [GO:0034122] cytoplasm [GO:0005737] kinase binding [GO:0019900] EAELHQLLLA;LESLELAF;PGGWRGSPMRFQASARA;QGGNRPVVSVSG 4 8.5 1.0018 -1.2561 0 0 0 0 0 0 0 0 9.2125 0 0 0 11.8295 0 0 A0A8I3N8W4 A0A8I3N8W4_CANLF ADP ribosylation factor like GTPase 5A ARL5A Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]; vesicle-mediated transport [GO:0016192] trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ILLTRIWRLFNHQEHKVIIVG;NVEEIVINNTRFLMWDI 2 21.2 0.93494 0.093393 0 6.4219 0 0 5.31107 0 0 0 0 0 0 0 0 0 0 A0A8I3N8W6 A0A8I3N8W6_CANLF Growth factor receptor bound protein 7 GRB7 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AWGSEEVPASA;DLIQNFLNAGSFPE;GAQLYKNYQ;LVGGGGSQCWVSQQILS;NHRLSLPTPGSG 5 10.9 1.0024 -1.0169 0 7.07521 0 0 0 0 0 0 0 0 10.1162 0 0 0 12.4859 A0A8I3N8X0 A0A8I3N8X0_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] RKEPWDLKTKKTVAIHPVL 1 17.4 0.95013 0.049568 0 0 0 0 0 0 6.26281 0 0 0 0 0 0 0 0 A0A8I3N8X1 A0A8I3N8X1_CANLF RUN domain-containing protein 3B RUNDC3B Canis lupus familiaris (Dog) (Canis familiaris) IEDSDLAHKLEKEQLEYIIVELQ;ISSDEEELRTLGS;SQNCICSI;SRGGGGGGG;TRSLGGLSGSRGGGGGGGKK 5 15.7 0.96626 0.048331 0 0 0 0 0 5.61005 0 0 0 0 0 0 0 0 0 A0A8I3N8X2 A0A8I3N8X2_CANLF RNA helicase (EC 3.6.4.13) DHX16 Canis lupus familiaris (Dog) (Canis familiaris) "antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; molecular adaptor activity [GO:0060090]; pattern recognition receptor activity [GO:0038187]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130] ADEEFLFGD;AERVRQRDKDRT;AGRVAAGKCFRLYTA;AREYRAAGEQEKLEATNRYHM;DLVEEESG;QEEEEEEEEISEKGR;VEEESGAPGEEQ;VLGLSERHVAQF 8 10 1.0032 -2.1383 0 0 0 0 0 3.61753 0 4.87553 10.4722 0 0 11.3756 9.74005 0 0 A0A8I3N8X4 A0A8I3N8X4_CANLF Signal transducer and activator of transcription STAT5A Canis lupus familiaris (Dog) (Canis familiaris) lactation [GO:0007595]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] QVKATIISEQQAKSLLK;VLKKHHKPHWNDGAILGF 2 4.6 0.96581 0.048313 0 0 0 0 0 0 0 7.16812 0 0 0 0 0 0 0 A0A8I3N8X5 A0A8I3N8X5_CANLF Homeobox A4 HOXA4 Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" GPGGGDGGPGGGPSYQQPPAPAA;HSGPGGGDGGPG;PGGGDGGP;PYGYRGGASPGRQPQPEQ;YTRQQVLELEKEFHF 5 18.3 1.0021 -1.2703 6.71672 8.97252 0 6.99571 7.85636 7.26641 0 0 0 0 0 0 0 0 0 A0A8I3N8Y1 A0A8I3N8Y1_CANLF Fibrinogen gamma chain FGG Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; protein polymerization [GO:0051258] fibrinogen complex [GO:0005577] signaling receptor binding [GO:0005102] GHLNGVYYQGGV;KTSTPNGYDNGII;SIQITYNPDEPPKPN 3 9.2 0 1.5254 9.24398 0 7.89772 8.88484 8.85599 9.1114 0 0 0 8.00602 7.802 0 7.66683 0 0 A0A8I3N8Y2 A0A8I3N8Y2_CANLF Regulator of chromosome condensation RCC1 Canis lupus familiaris (Dog) (Canis familiaris) G1/S transition of mitotic cell cycle [GO:0000082]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225] chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; protein heterodimerization activity [GO:0046982]; small GTPase binding [GO:0031267]; sulfate binding [GO:0043199] PEDALPKSKKVKDRRN 1 3.5 0.9553 0.049233 9.73298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N8Y8 A0A8I3N8Y8_CANLF Peptidoglycan recognition protein 1 PGLYRP1 Canis lupus familiaris (Dog) (Canis familiaris) peptidoglycan catabolic process [GO:0009253] extracellular region [GO:0005576] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; zinc ion binding [GO:0008270] FVVKLKVL;FVVKLKVLGDKSQ;ISFMGNYMGKCPAV;VGSGLWLC 4 21.2 1.0033 -2.0878 0 0 0 0 0 0 8.77442 0 7.77591 0 0 0 0 7.83996 4.42438 A0A8I3N8Z2 A0A8I3N8Z2_CANLF Homeobox protein Hox-A5 HOXA5 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; bronchiole development [GO:0060435]; cell migration [GO:0016477]; cell-cell signaling involved in mammary gland development [GO:0060764]; embryonic skeletal system morphogenesis [GO:0048704]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; intestinal epithelial cell maturation [GO:0060574]; lung alveolus development [GO:0048286]; lung goblet cell differentiation [GO:0060480]; lung-associated mesenchyme development [GO:0060484]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal-epithelial cell signaling [GO:0060638]; multicellular organism growth [GO:0035264]; negative regulation of angiogenesis [GO:0016525]; negative regulation of erythrocyte differentiation [GO:0045647]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of myeloid cell differentiation [GO:0045639]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; respiratory system process [GO:0003016]; thyroid gland development [GO:0030878]; trachea cartilage morphogenesis [GO:0060535] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GTASGAEEDAPASSEQASA 1 5 0.98495 -0.23895 0 0 0 0 0 0 0 0 0 0 7.46581 7.28531 7.62965 0 7.81596 A0A8I3N8Z7 A0A8I3N8Z7_CANLF SLAIN motif family member 2 SLAIN2 Canis lupus familiaris (Dog) (Canis familiaris) DELRDAASLLAAGE;KQLILPGN;LSGWEEEEESWL;SSIDSELSASELDEDSIGSN;STPVRPPI 5 10.7 1.0033 -1.569 10.1694 10.3298 0 0 0 0 10.1145 8.64692 10.5553 10.2497 10.5013 10.1631 0 9.98285 0 A0A8I3N905 A0A8I3N905_CANLF Ankyrin repeat and SOCS box containing 3 ASB3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] AAREGNVKVLRKLLKKGRSV;NVKVLRKLLKK;SENYIKTKTFE 3 7 0.98834 -0.47551 0 10.0268 7.78647 0 0 0 3.82934 0 0 0 0 0 0 0 0 A0A8I3N919 A0A8I3N919_CANLF MHC class I DLA-64 LOC119876868 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DAATGRMEPRAPWVEQ;GSHTFQWMFGCDLGPGGR;LTVQQTLGKMKARVSP;STPEPPGRSCST 4 15.5 0.9874 -0.50359 0 0 8.93174 0 0 0 0 0 0 0 0 0 0 0 13.6962 A0A8I3N929 A0A8I3N929_CANLF Hes related family bHLH transcription factor with YRPW motif like HEYL Canis lupus familiaris (Dog) (Canis familiaris) atrioventricular valve morphogenesis [GO:0003181]; cardiac ventricle morphogenesis [GO:0003208]; cellular response to BMP stimulus [GO:0071773]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; glomerulus development [GO:0032835]; mesenchymal cell development [GO:0014031]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; positive regulation of neuron differentiation [GO:0045666]; proximal tubule development [GO:0072014]; pulmonary valve morphogenesis [GO:0003184]; skeletal muscle cell differentiation [GO:0035914]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; nucleus [GO:0005634] "AF-1 domain binding [GO:0050683]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QARKKRRGIIEKRRR 1 4.6 0.95722 0.053874 0 0 0 4.66095 0 4.66129 0 0 0 0 0 0 0 0 0 A0A8I3N944 A0A8I3N944_CANLF Suppressor of tumorigenicity 7 protein ST7 Canis lupus familiaris (Dog) (Canis familiaris) EQLKSCIVWSWTYLWT;EVSVYPKKEL;GVDNNSSNNSNSSNGDSDS;KRVEGALNLLHCTWEGTFH;KYGTSFIEQVSVSHL;VLAKYDDIS;VLFLVYVLRVPL 7 19.1 0.99861 -0.60823 7.39609 0 0 4.97425 0 0 10.0282 4.58773 0 0 6.73349 0 0 0 3.01849 A0A8I3N945 A0A8I3N945_CANLF Kelch like family member 10 KLHL10 Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; spermatid development [GO:0007286] cytoplasm [GO:0005737] HEQRSDASAT;LPYAILFAIG;RQKAYMFILHNFEEMVKV;VECYDEKTDEWYDAHDM;VLLPKVRLA 5 10.5 1.0037 -0.81223 0 5.34997 8.33503 0 0 0 0 0 0 6.94533 0 0 0 0 0 A0A8I3N951 A0A8I3N951_CANLF Uncharacterized protein MLX Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] DNSLDPDDEDSDYHQES;LFQSFNASISVASFQ;RCPSLWVAH;VPPPFGPRGCRE 4 11.3 0.99311 -0.27996 0 0 0 8.37842 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N954 A0A8I3N954_CANLF Achaete-scute family bHLH transcription factor 2 ASCL2 Canis lupus familiaris (Dog) (Canis familiaris) chorionic trophoblast cell development [GO:0060719]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; positive regulation of T cell migration [GO:2000406]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spongiotrophoblast differentiation [GO:0060708]; T follicular helper cell differentiation [GO:0061470] cytoplasm [GO:0005737]; nucleus [GO:0005634] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" AARRRPTSP;AEHDAVRAA;AYSSDDSGCEGALS;LVNLGFQALRQHV;VETLRSAVEYIRAL 5 30.4 0.98679 -0.39753 7.36186 0 0 7.34882 0 0 8.00529 0 5.57225 0 0 0 0 0 8.28012 A0A8I3N957 A0A8I3N957_CANLF RNA binding motif single stranded interacting protein 2 RBMS2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729] LDPRALAVVQESG;NLYISNLPL;QPSGSVLPPGMDHPI;SLQPASMMGPL 4 11.2 1.0026 -0.79102 0 0 0 0 0 0 0 0 0 0 9.50912 0 0 0 0 A0A8I3N963 A0A8I3N963_CANLF "Fli-1 proto-oncogene, ETS transcription factor" FLI1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" ERRVIVPADP;KFDFHGIAQALQPHPTES;TQEHVRQWLEW;YYYDKNIMTKVHG 4 13.8 0.94615 0.084773 0 4.06342 0 0 0 0 0 0 0 0 0 8.9695 0 0 0 A0A8I3N972 A0A8I3N972_CANLF Zinc finger homeobox 3 ZFHX3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; response to transforming growth factor beta [GO:0071559] cytoplasm [GO:0005737]; nuclear body [GO:0016604]; transcription regulator complex [GO:0005667] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AAEEAEEEEEEEEAEEE;AATMCCLCQRSF;AYSAPAPS;CYKDEDEEGQDDS;EAEEEEEEEEAEEEEEEEEEEEEEE;FPFYIPSAEFQLNPE;GGGGGGGG;GGVGGGGG;GPVEPLPADLAQLY;GVGGGGGGGGGGGSYHCLAC;LAAQQQGMFDN;LVSEELMNLGESFIQ;SLPEDEWKA;STEGDDGGFVPHHQHA;TDNLDMLGLHMNVERS;VGGGGGGG;VGGGGGGGG;VGLKKRVVQVWFQNT 18 5.5 0.97647 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 5.86066 0 0 A0A8I3N978 A0A8I3N978_CANLF Transmembrane protein 151B TMEM151B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDEDDDEEEEAGPPP;EAGPPPPYHDAL;GGGGGGGG;GGGGGGPG;HYHVEKLFGLEGPG;LSSQASMGDDEDDDEEEEAG;PAREEQRPIQ;SLLMYGCL;TVDSTELE 9 14 1.0011 -0.93496 8.73637 0 8.19229 0 0 0 0 0 0 8.40544 10.8969 9.60387 0 5.01217 0 A0A8I3N979 A0A8I3N979_CANLF "Polycystin 1 like 1, transient receptor potential channel interacting" PKD1L1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; membrane [GO:0016020] AAASSGFGG;GDTNGPAG;LWKPFRATQEPFMSTPMAL;TDIDITFLA;TNGPAGLA;WNEELSLRAECDACAAGP 6 2.8 1.0031 -2.4143 0 11.2178 10.8542 0 0 0 0 10.6192 0 7.93834 0 0 0 0 0 A0A8I3N9B4 A0A8I3N9B4_CANLF Olfactory receptor OR8B60 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLSMDQGKVSTVF 1 4.2 0.99517 -0.018637 0 0 0 0 0 0 0 0 0 0 9.4672 0 0 0 0 A0A8I3N9B5 A0A8I3N9B5_CANLF Nuclear RNA export factor 1 NXF1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nuclear speck [GO:0016607] RNA binding [GO:0003723] AEYFKDSRNVKKLKDPT;LSPEQQEML;VLHFLQQYYAVYDSGDRQRLLD;VPPHSVQNELKPEQVEQL 4 10.7 0.99098 -0.14669 0 0 0 0 7.77531 6.91301 0 0 0 0 0 0 0 7.40114 0 A0A8I3N9B8 A0A8I3N9B8_CANLF Regulator of G protein signaling 3 RGS3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; plasma membrane [GO:0005886] GRPVTNNW 1 2.7 0.99012 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 8.99963 0 0 A0A8I3N9C0 A0A8I3N9C0_CANLF "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2" SPOCK2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539] KPETCTGQDLADLGDRLRD;NFMEDEQWLSSISQ;SDGHTYSS;VEDDYIKSWEDNQQGDEA;VGFSGDFGSGVGWED 5 17.5 0.98779 -0.3683 0 0 0 0 0 0 0 8.26651 0 0 0 0 10.701 9.57287 12.6562 A0A8I3N9C5 A0A8I3N9C5_CANLF Paired like homeobox 2A PHOX2A Canis lupus familiaris (Dog) (Canis familiaris) locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; noradrenergic neuron differentiation [GO:0003357]; oculomotor nerve formation [GO:0021623]; regulation of respiratory gaseous exchange [GO:0043576]; somatic motor neuron differentiation [GO:0021523]; sympathetic nervous system development [GO:0048485]; trochlear nerve formation [GO:0021642] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GGGGGGPG;THYPDIYTREELAL 2 7.7 0.94192 0.061104 0 0 0 0 0 0 0 7.66541 0 0 0 0 0 0 0 A0A8I3N9C7 A0A8I3N9C7_CANLF Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) HAS2 Canis lupus familiaris (Dog) (Canis familiaris) atrioventricular canal development [GO:0036302]; bone morphogenesis [GO:0060349]; cellular response to fluid shear stress [GO:0071498]; cellular response to interleukin-1 [GO:0071347]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to tumor necrosis factor [GO:0071356]; endocardial cushion to mesenchymal transition [GO:0090500]; extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of monocyte aggregation [GO:1900625]; vasculogenesis [GO:0001570] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; plasma membrane raft [GO:0044853] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] EDWYNQEFMGSQCSFGDD 1 3.3 0.97263 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 3.06867 0 A0A8I3N9D2 A0A8I3N9D2_CANLF Filamin A interacting protein 1 FILIP1 Canis lupus familiaris (Dog) (Canis familiaris) modification of postsynaptic structure [GO:0099010] actin cytoskeleton [GO:0015629]; glutamatergic synapse [GO:0098978]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] DELVKLKS;ELVKLKSFAL;EQKFRTEQ;IERLKKRLQQLE;QQLEEIKH;STITITPV 6 4.4 0.99913 -3.1135 0 0 0 0 9.04696 0 8.31692 0 6.98162 0 0 0 0 0 0 A0A8I3N9E0 A0A8I3N9E0_CANLF WD repeat domain 31 WDR31 Canis lupus familiaris (Dog) (Canis familiaris) SVVAALNSD;TSEDKTIRLWDSRGLQ;YCEVSEDGHKCISCSNGFGGE;YSPAHVDTVS 4 15 1.0021 -1.3049 0 0 0 0 9.74927 0 0 0 0 0 0 0 0 11.8779 0 A0A8I3N9E9 A0A8I3N9E9_CANLF Adenosine 5'-monophosphoramidase HINT1 (Desumoylating isopeptidase HINT1) (Histidine triad nucleotide-binding protein 1) HINT1 Canis lupus familiaris (Dog) (Canis familiaris) purine ribonucleotide catabolic process [GO:0009154] cytoplasm [GO:0005737]; nucleus [GO:0005634] hydrolase activity [GO:0016787] IWETGQPGWLSGL 1 9 0.99298 -0.14341 0 0 0 0 0 0 10.319 0 0 0 0 0 0 0 0 A0A8I3N9F1 A0A8I3N9F1_CANLF Fidgetin-like protein 1 FIGNL1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to ionizing radiation [GO:0071479]; male meiotic nuclear division [GO:0007140]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569] nuclear chromosome [GO:0000228]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ATPLFGNVRKHSN;EHESSRRIKTEFLV;IDEIDSLLSQRG 3 5.8 0.67518 0.29269 0 0 0 0 9.02589 6.03018 0 0 0 8.73037 0 0 0 0 0 A0A8I3N9F8 A0A8I3N9F8_CANLF Kelch like family member 35 KLHL35 Canis lupus familiaris (Dog) (Canis familiaris) ESCGVTVC;IYVIGGAGQDGVSTNKVQC;SLAERCGRVLRQA 3 6.9 1.0028 -0.98454 0 0 0 8.87931 0 6.26858 0 0 0 0 0 0 2.88004 0 0 A0A8I3N9G1 A0A8I3N9G1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FFFFCPFLNWIIWFWRVL 1 20.9 0.98046 0.048313 0 0 0 0 0 0 0 0 6.86158 0 0 0 0 0 0 A0A8I3N9G3 A0A8I3N9G3_CANLF "Proteasome 26S subunit, non-ATPase 7" PSMD7 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] nucleoplasm [GO:0005654]; proteasome regulatory particle [GO:0005838] metallopeptidase activity [GO:0008237]; protein homodimerization activity [GO:0042803] NELMKRYCPNSVLVIIDVKPK 1 6.5 0.97721 0.047166 0 0 0 0 0 0 0 0 0 4.42082 0 0 0 0 0 A0A8I3N9G6 A0A8I3N9G6_CANLF Cyclin-dependent kinase inhibitor domain-containing protein CDKN1C Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861] EGAGDSPP;GGSPGGLGRGTRRNAYTAHCAGD;LLLLLLLFLSSPLPRP;LLLLLLLL;LLLLLLLLFLSS;PPPPPRSQEPLAEPLHSGIPGR;RMTVRQWGWLPVAPPQGWPC 7 13.3 1.0022 -1.2286 0 7.50692 0 8.98937 0 0 0 0 8.71997 0 0 0 0 0 0 A0A8I3N9H6 A0A8I3N9H6_CANLF Lysyl oxidase homolog (EC 1.4.3.13) LOX Canis lupus familiaris (Dog) (Canis familiaris) ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; osteoblast differentiation [GO:0001649]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of protein phosphorylation [GO:0001932]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720] DDNPYYNY;EDTSCDYGYHR 2 4.6 0.98811 -0.47639 0 0 0 0 0 0 0 4.5828 0 0 0 0 0 0 0 A0A8I3N9H8 A0A8I3N9H8_CANLF Four and a half LIM domains protein 5 FHL5 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] SNECSSKCFH;SNECSSKCFHCKKTI 2 5.3 1.001 -0.92344 0 0 0 0 0 0 0 0 0 0 0 0 7.79643 0 0 A0A8I3N9J3 A0A8I3N9J3_CANLF Regulatory protein SIR2 homolog 7 (SIR2-like protein 7) SIRT7 Canis lupus familiaris (Dog) (Canis familiaris) "DNA repair-dependent chromatin remodeling [GO:0140861]; homologous chromosome pairing at meiosis [GO:0007129]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; R-loop processing [GO:0062176]; regulation of DNA repair [GO:0006282]; regulation of mitochondrion organization [GO:0010821]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901836]; retrotransposon silencing [GO:0010526]; rRNA transcription [GO:0009303]; transcription initiation-coupled chromatin remodeling [GO:0045815]" nuclear speck [GO:0016607]; nucleolus organizer region [GO:0005731]; site of double-strand break [GO:0035861] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; NAD-dependent histone H3K18 deacetylase activity [GO:0097372]; protein methyltransferase activity [GO:0008276]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-propionyllysine depropionylase activity [GO:0106231]; protein-succinyllysine desuccinylase activity [GO:0036055] DTILCLGSSLKVLKKY;RGAALSSAPVLGGWFGRGCAKR;RPAGRRKRKRGPPG 3 10.7 0.8555 0.15911 0 0 0 5.31172 0 0 0 0 10.9912 0 0 0 0 0 6.8089 A0A8I3N9L8 A0A8I3N9L8_CANLF Migration and invasion enhancer 1 MIEN1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of cell migration [GO:0030335]; positive regulation of filopodium assembly [GO:0051491] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] LGGTGAFE 1 7 1.0039 -1.1044 6.58721 0 0 0 0 0 0 0 0 0 0 0 0 8.66292 0 A0A8I3N9M6 A0A8I3N9M6_CANLF Uncharacterized protein SOHLH1 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] LRLVGTLLPGQ;PLVSEEAQSCLCQAGEPPA;VGCPSLAL 3 11.3 0.98887 -0.26241 0 0 9.87172 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N9M9 A0A8I3N9M9_CANLF Scm polycomb group protein homolog 1 SCMH1 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283] chromocenter [GO:0010369]; male germ cell nucleus [GO:0001673] EMAPIRIFHKEP;LFCFLHGPKWPCAT;NDFWRLVDSAE;RKHQEMLVCYS;VGWCSLTGDNLQ;VLVTFDGWRGAFDYWC 6 10.4 1.0041 -0.81158 8.02359 0 0 8.58853 0 0 0 0 8.83099 0 0 0 0 0 10.241 A0A8I3N9P5 A0A8I3N9P5_CANLF TatD DNase domain containing 2 TATDN2 Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on ester bonds [GO:0016788]" GRGGSPGP;VGFTAVLTYSSAWEA 2 3 0.99069 -0.21107 0 0 0 0 0 0 9.51381 0 0 0 0 0 6.99288 0 0 A0A8I3N9Q3 A0A8I3N9Q3_CANLF Uncharacterized protein IFNL3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response to virus [GO:0051607]; positive regulation of immune response [GO:0050778] extracellular region [GO:0005576] cytokine activity [GO:0005125] DLQQLKVWERP 1 5.6 0.98038 0.035491 0 0 0 0 0 0 0 0 0 0 10.0852 0 0 0 0 A0A8I3N9Q4 A0A8I3N9Q4_CANLF Uncharacterized protein RANBP2 Canis lupus familiaris (Dog) (Canis familiaris) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nuclear pore [GO:0005643] GTPase activator activity [GO:0005096] AELLCKNDVTDGR;DLEKDDDAYRTEDSDDIHF;ETSRLETN;QTKVTDGESESSDAGSANASD;SCVVQTLKVPRPKIKLIKGE;SFYDQREYIGRSVH;SIPEPTDP;VGQWKERGIGDIKILQ;VQTLKVPRPKIKLIKG 9 7.9 0.93694 0.097439 0 0 8.50446 0 0 0 0 0 0 4.12242 0 0 0 0 0 A0A8I3N9R1 A0A8I3N9R1_CANLF FRAS1 related extracellular matrix 1 FREM1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell communication [GO:0007154] membrane [GO:0016020] HTRPVSSFTWKDLSDL;IVILVKPLV;LHGICFNITI;LLKKGMKLMYVHDDSET;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LQTKRGVFEIIL;LWDGDNRSPAFDCHITI;QEEVDLNLLRYT;SETLADDFTIQ;SIPKDCTLE;TDIIYHYHGMVSQKL;TPVNDEKPMLSKKAE;TVLLQHNFT 15 7.4 0.99717 -3.6217 9.97943 11.9496 0 0 8.02292 0 11.2387 11.1257 12.3151 0 10.8271 0 9.56602 0 9.45339 A0A8I3N9R9 A0A8I3N9R9_CANLF Glial cells missing transcription factor 1 GCM1 Canis lupus familiaris (Dog) (Canis familiaris) astrocyte fate commitment [GO:0060018]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation involved in embryonic placenta development [GO:0060706]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; syncytium formation by plasma membrane fusion [GO:0000768]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" CCPNYPFPLTSWPYDFP 1 3.9 0.98321 0.046227 0 0 0 6.17035 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N9S0 A0A8I3N9S0_CANLF Regulation of nuclear pre-mRNA domain-containing protein RPRD1A Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] nucleus [GO:0005634] RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] DAAVHQRIASLP;LLADYNGRLAAEIDDRK;LTFLYLANDV 3 12.9 0.98742 -0.49697 0 0 0 0 0 13.5002 0 0 0 0 10.2639 0 0 0 0 A0A8I3N9S6 A0A8I3N9S6_CANLF Ribosomal protein L39 LOC106557657 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] KTFRIKRFLAKKQKQNC 1 33.3 0.98406 0.046227 0 0 0 0 0 6.62154 0 0 0 0 0 0 0 0 0 A0A8I3N9S8 A0A8I3N9S8_CANLF LDL receptor related protein 1 LRP1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta clearance by transcytosis [GO:0150093]; phagocytosis [GO:0006909]; positive regulation of endocytosis [GO:0045807]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of protein localization to plasma membrane [GO:1903078]; receptor-mediated endocytosis [GO:0006898] basolateral plasma membrane [GO:0016323]; early endosome [GO:0005769]; receptor complex [GO:0043235] alpha-2 macroglobulin receptor activity [GO:0016964]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-containing complex binding [GO:0044877] ADADCMDGSDEE;AGCSHSCS;AIALDPRDGILFW;ASILIPLLLLLLLLLLV;CDADADCMDGSD;CDADADCMDGSDEE;CDADADCMDGSDEEAC;CDADADCMDGSDEEACGT;CDGDNDCQDNSDEAN;CDGDSDCEDNSDEENCE;CDGDTDCMDSSDEKSCEG;CDGEDDCG;CDGEDDCGDGSD;CDGEDDCGDGSDE;CDGEDDCGDGSDEPK;CDGEDDCGDNSDENP;CDGENDCHDQ;CDGNDDCGDGS;CDGNDDCGDGSDEGE;CDGSDDCGDGSD;CDNDNDCGDNSDEAG;CGDGTDEEDCE;CGDGTDEEDCEPPTAQTPHCKDKK;CGDHSDEPPDCPEFKCRPG;CMDSSDEKSCEGVTH;CNMFDDCGDGSDE;CNMFDDCGDGSDEEDC;CNQFVDCEDASDEMNC;CSARTCPPNQFSCASG;DADCMDGSDEEACGTGVRTCPL;DCADGADE;DDCGDGSDEEDC;DDCGDGSDEEDCS;DDCGDHSDEPPDCP;DERDCPEVTCA;DGDNDCQDNSDE;DGDNDCQDNSDEANCDIHV;DGDSDCEDNSDEENCESL;DGEDDCGDN;DGSDDCGDGSDEAAHCEGKTC;DGSDEPANCTQMTCGV;DNDCQDNSDEANCD;DNDNDCGDN;DTEDDCGDHSDEPPDCP;DTEDDCGDHSDEPPDCPEFKCRPGQ;DYDNDCGDNSDEESC;DYDNDCGDNSDEESCTP;ECDGENDCHDQS;EDDCGDHSDEPPDC;EHWTCDGDND;EKDIRTPNGLAIDHRAE;ENNRCIPNRWLCDGDNDCG;FDDCGDGSDEEDCSI;GADDCGDG;GDNDCGNSEDESN;GDNDCQDNSDEAN;GDSDCEDNSDEENCES;GKGRPGII;GWMYWTDWEEDP;ITVHPEKGYLFWTE;KNDKCIPFWWKCDTEDDCGDH;LCDGNDDCGDG;LCDGNDDCGDGSDEGELCDQC;LCDGNDDCGDGSDEGELCDQCS;LCNGQDDCGDGSDE;LLCNGQDDCGDGSDERACHVN;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLV;LSSRQWECDGENDCHDQSDE;MFDDCGDGSDEEDC;MFDDCGDGSDEEDCSID;PGHMASILIPLLLLLLLL;PGQFQCST;PLDKLCDGNDDCGDGSDE;PLLLLLLLLL;PLLLLLLLLLLVAGV;PNRWLCDGDNDCGNSEDE;QCDYDNDCGDNSDEE;RWKCDGEDDCGDGS;RWQCDYDNDCGDNSDEESCT;SCRGGRILQED;SDDCGDGSDEA;SDESPECEYPTCGPN;SILIPLLLLLLLLLLVA;SILIPLLLLLLLLLLVAGVV;SLCYAPSWVCDGANDCGDYSD;SSRQWECDGENDCHDQSDEAPKNP;TCDKEDDCEHG;TLYGGEVYWTDWR;VCDRDNDCVDGSDEPANCT;VDWIAGNIYWTDQGFD;VGHCSNGGSCTMNS;VHPLRGKLYWTDG;VLSSNNMDMF;VPGRWQCDYDNDCGDNSDEES;WQCDYDNDCGDNSDEE;WQCDYDNDCGDNSDEESCT;WRCDNDNDCGDNSDEAGCSH;YFVDDIDDRIFVCNRNGD;YHNERLYWADA 102 15.5 0.99323 -0.16038 0 5.97214 0 0 2.73197 0 0 5.83274 0 0 4.17449 0 0 0 0 A0A8I3N9S9 A0A8I3N9S9_CANLF Growth arrest specific 2 like 2 GAS2L2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule bundle formation [GO:0001578]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110] actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; microtubule binding [GO:0008017] KVNLSAKETRMKKVPGQ;LVSHCTCPVQFSMIKVSEG;PPTSSSPRAHSER;QELALPPPD;SVDARQGDQK;YKLKLRPRIRPRRDHR 6 9.6 1.0028 -1.0055 0 0 0 9.16837 0 0 9.93373 0 0 0 0 10.4836 0 8.65703 0 A0A8I3N9T2 A0A8I3N9T2_CANLF Zinc finger SWIM-type containing 6 ZSWIM6 Canis lupus familiaris (Dog) (Canis familiaris) Cul2-RING ubiquitin ligase complex [GO:0031462] zinc ion binding [GO:0008270] CYHDDTENSLF;EQFMADPRLSL;FQMNRDQLQKFV;FTENMGQCKSLE;GGGGGGGG;MDSLPDIT;NCALSALTLCEKD;PGGGGGGG;YALDSIMQSWF 9 7.4 1.0033 -2.0569 0 0 0 0 0 9.07398 0 0 10.5178 10.5222 0 0 0 6.74066 10.621 A0A8I3N9T5 A0A8I3N9T5_CANLF BUB1 mitotic checkpoint serine/threonine kinase BUB1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly checkpoint signaling [GO:0007094] kinetochore [GO:0000776] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] HMFIKFYSAH;MWSEFFHIMLNIPDCHH;NPWEFYIGTQ;PLYVAWAGHLEGQGE 4 5.1 1.0026 -0.77272 9.54048 0 0 0 8.84818 0 0 0 0 7.75174 0 0 0 20.2441 0 A0A8I3N9T7 A0A8I3N9T7_CANLF Uncharacterized protein ZNF350 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] IQSRTHTG 1 1.4 0.98958 -0.26321 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0304 A0A8I3N9U5 A0A8I3N9U5_CANLF Acid sensing ion channel subunit 3 ASIC3 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280] PRRGLWAAAVL;YISENVLVL 2 3.8 0.99498 -0.11721 14.1044 8.98814 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3N9U6 A0A8I3N9U6_CANLF Collagen type XXI alpha 1 chain COL21A1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] DGSRGEPGIPGFPG;DILLGLGVKKKVKKRILL;ESIHYLGG;FPGLPGRDG;GECLNGPSDVGSTPAP;GVKKKVKKRIL;GVKKKVKKRILLSP;GVKKKVKKRILLSPT;GVKKKVKKRILLSPTKI;GVKKKVKKRILLSPTKIKG;KGFDILLGLGVKKKVKKRILLS;KKKVKKRILL;KKMWDLWRIL;LGVKKKVKKRILLSPTKIKG;LLGLGVKKKVKKRILLSP;VKKKVKKR;VKKKVKKRIL 17 8.9 0.997 -4.0458 0 7.47184 0 4.74131 6.02565 0 0 0 0 0 0 4.23005 10.1789 9.16569 8.42689 A0A8I3N9Y8 A0A8I3N9Y8_CANLF Tensin 4 TNS4 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925] DFQAPSNPTPNMGQPRAT;EDLDSYIDFSLESLNQMILEL;TSKYWFKPSI 3 6.9 0.98998 -0.50973 0 0 6.06695 0 0 0 0 5.94722 3.60063 0 0 0 0 6.56079 6.54353 A0A8I3N9Z6 A0A8I3N9Z6_CANLF Interleukin 1 receptor associated kinase 1 binding protein 1 IRAK1BP1 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] cytoplasm [GO:0005737]; nucleus [GO:0005634] signaling adaptor activity [GO:0035591] ISQPQFYHTPGSVENLRRQ;SVCRRLDYITQSLRQQGLQAENV;TKEWEGQIDDLQ 3 20.8 0.98897 -0.20395 0 0 4.57719 0 0 0 0 9.8008 0 0 0 0 0 5.60807 0 A0A8I3N9Z9 A0A8I3N9Z9_CANLF WASH complex subunit 3 (Coiled-coil domain-containing protein 53) WASHC3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041]; exocytosis [GO:0006887] WASH complex [GO:0071203] NRFSTVCEEKLADLSL;SEGLDPDL 2 12.4 0.98127 -0.24889 0 0 0 0 0 0 0 0 0 9.34612 0 0 0 0 0 A0A8I3NA03 A0A8I3NA03_CANLF N-acetyl-alpha-glucosaminidase NAGLU Canis lupus familiaris (Dog) (Canis familiaris) adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular lipid catabolic process [GO:0044242]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; cerebellar Purkinje cell layer development [GO:0021680]; collagen metabolic process [GO:0032963]; cone retinal bipolar cell differentiation [GO:1904390]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; ganglioside metabolic process [GO:0001573]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin metabolic process [GO:0030202]; hormone metabolic process [GO:0042445]; inner ear receptor cell development [GO:0060119]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; limb development [GO:0060173]; liver development [GO:0001889]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; maintenance of blood-brain barrier [GO:0035633]; microglia differentiation [GO:0014004]; microglial cell activation [GO:0001774]; middle ear morphogenesis [GO:0042474]; mitral valve morphogenesis [GO:0003183]; motor behavior [GO:0061744]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nerve development [GO:0021675]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein processing [GO:0016485]; response to disaccharide [GO:0034285]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; rod bipolar cell differentiation [GO:1904389]; sequestering of iron ion [GO:0097577]; superoxide metabolic process [GO:0006801]; toll-like receptor 4 signaling pathway [GO:0034142]; vesicle tethering [GO:0099022] extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202] alpha-N-acetylglucosaminidase activity [GO:0004561] AHLYEQNSRYQLTLWGPE;LAAESGLDTYR;LFAESQPVY;LLGAAGGA;LTLWGPEGNI;LVADYYTPRWRL;NHIYGADTFNEMQPPS;SEPSYLASATAS 8 11.9 1.0031 -1.7093 0 0 10.2509 0 0 13.7271 0 0 17.6538 11.0797 0 0 0 0 0 A0A8I3NA04 A0A8I3NA04_CANLF NudE neurodevelopment protein 1 NDE1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell division [GO:0051301]; cell migration [GO:0016477]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; nervous system development [GO:0007399]; vesicle transport along microtubule [GO:0047496] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule [GO:0005874]; spindle [GO:0005819] microtubule binding [GO:0008017] DSMGGTPLTPAARISALNIVGDL;ETIKEKFE;VEAERTDTAVQATG 3 13.4 1.0033 -1.6441 0 0 8.93251 0 0 0 0 0 11.1351 0 0 0 0 0 0 A0A8I3NA14 A0A8I3NA14_CANLF Annexin A10 ANXA10 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] TEENCLIDI 1 2.9 1.004 -0.80421 0 0 0 0 0 0 0 8.61206 0 0 0 0 0 0 0 A0A8I3NA29 A0A8I3NA29_CANLF Uncharacterized protein LYPD8 Canis lupus familiaris (Dog) (Canis familiaris) VIITAFAVAAV 1 4.3 0.98392 0.035491 0 0 0 0 7.01714 0 0 0 0 0 0 0 0 0 0 A0A8I3NA33 A0A8I3NA33_CANLF Uncharacterized protein RRN3 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase I promoter [GO:0006361] RNA polymerase I general transcription initiation factor activity [GO:0001181] DEDEDTERDTKADQQ;EHLWKKLQDPNNPA;EQLISILLRLQW;TERDTKADQQRLDH;YIGSFLARAKFIPLIT 5 9.7 0.98761 -0.40455 0 0 0 0 9.08534 0 10.7241 8.48583 0 0 0 7.14863 0 0 0 A0A8I3NA47 A0A8I3NA47_CANLF Rab3 GTPase-activating protein catalytic subunit RAB3GAP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] GTPase activator activity [GO:0005096] DEVLEDVIPQS;EMRFRWENN;IIHKLFVNAQRHLILFKA;KVKEEENLENISSVKKIIK;PHWSVRVRKADNPQCLLGD;QDSADKEGKDEVLEDVIP;WSDSEEEFFECLSDTEEL 7 10.5 1.0013 -0.94106 0 8.32012 0 9.72984 7.66888 7.01257 0 0 0 0 0 0 0 11.6532 0 A0A8I3NA52 A0A8I3NA52_CANLF Beta-synuclein SNCB Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; synapse organization [GO:0050808]; synaptic vesicle endocytosis [GO:0048488] axon terminus [GO:0043679]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025] cuprous ion binding [GO:1903136] GAVFSGAGN 1 7.5 0.98861 -0.21799 8.62618 0 0 0 0 0 0 0 8.83996 0 0 0 0 0 0 A0A8I3NA56 A0A8I3NA56_CANLF Progestin and adipoQ receptor family member 8 PAQR8 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] AFAEAEALPWAATRSL;LSHYTFYFVD;VPAGLAFV 3 9.6 0.98686 -0.39653 0 0 0 7.45648 0 0 0 6.95105 0 0 0 0 0 0 8.97642 A0A8I3NA66 A0A8I3NA66_CANLF Ubiquilin 4 UBQLN4 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] autophagosome [GO:0005776]; cytosolic proteasome complex [GO:0031597]; endoplasmic reticulum membrane [GO:0005789]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734] identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435] DAGSGSRRSSGGGPSPGA;FMNREANLQALIATGGD;GSGSRRSSGGGPSPGAGEGP;VPLFAGNPQL 4 8.2 0.98318 0.046227 10.0488 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NA72 A0A8I3NA72_CANLF Sm domain-containing protein LSM8 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] GAAAHACWCPGRWRRPR;PSARRSLW;VIGEIDEETDSALDL 3 12.9 0.99491 -0.1587 0 8.3969 7.75141 0 0 0 0 7.36089 0 0 0 0 0 0 0 A0A8I3NA78 A0A8I3NA78_CANLF Uncharacterized protein CCT8L2 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] EHPAARLLREA 1 2 0.98212 -0.24839 0 0 0 0 0 0 13.0326 0 0 0 0 0 0 0 0 A0A8I3NA79 A0A8I3NA79_CANLF Transmembrane protease serine (EC 3.4.21.-) LOC482176 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] DTMLCAGYLEGNKDA;EGVVVTGWG;LPEATQVFPP;PLWMIALIV;PVIASRPSLPLWMI 5 12.5 1.0035 -2.4477 9.47226 10.2809 10.6418 0 0 0 0 0 0.29537 0 0 0 0 0 0 A0A8I3NA80 A0A8I3NA80_CANLF Protein CASP CUX1 Canis lupus familiaris (Dog) (Canis familiaris) intra-Golgi vesicle-mediated transport [GO:0006891] Golgi membrane [GO:0000139] GAAELGLEKIPEPI;SESMERDCAT;SNSDLSGRCA;YWKRFDLQQLQD 4 7.2 0.99159 -0.27268 0 0 0 0 0 0 0 0 0 0 0 0 8.93643 0 0 A0A8I3NA84 A0A8I3NA84_CANLF Cell division cycle associated 7 like CDCA7L Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] IFIEDTDSEMEE;NIKENKAMLAQLLA;SDLSDAGKESLVSEEEEED 3 9.9 1.0026 -0.77564 0 0 0 0 0 0 0 0 0 15.094 13.3095 0 0 0 0 A0A8I3NA99 A0A8I3NA99_CANLF Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) PLPPR1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] neuron projection [GO:0043005]; plasma membrane [GO:0005886] phosphatidate phosphatase activity [GO:0008195] IPCFIFVELVIMAGTVLLAYYFE 1 7.1 0.9737 0.046824 0 0 6.61706 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAA4 A0A8I3NAA4_CANLF Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) CDK14 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] AAFPGMKDIQ;DRLSCHHSGKKKKKTLM;GVGCIFVEMI;GVGCIFVEMIQ;NEDTWPGV;VHTDLCQYMDKHPGG 6 13.9 0.97744 0.046227 0 0 0 0 0 0 9.82574 0 0 0 0 0 0 0 0 A0A8I3NAC2 A0A8I3NAC2_CANLF Coiled-coil domain containing 90B CCDC90B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] LVQDLETHG;RCVWWLVRSE;TEIASLKTL 3 11 0.99707 -0.59357 0 11.8805 0 0 0 0 12.3587 12.4577 0 0 0 0 0 0 0 A0A8I3NAC3 A0A8I3NAC3_CANLF Osteoclastogenesis associated transmembrane protein 1 OSTM1 Canis lupus familiaris (Dog) (Canis familiaris) osteoclast differentiation [GO:0030316]; transepithelial chloride transport [GO:0030321] chloride channel complex [GO:0034707]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] ATAARRRSLLLLLLLLLLW;KKRKLILPKRLKS;LFNHTLTCFEHNLQ;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;TVPVIAVSVF 7 17.1 0.99709 -0.098934 0 5.71243 4.53126 0 0 0 0 0 0 0 0 0 5.25942 0 12.42 A0A8I3NAC6 A0A8I3NAC6_CANLF Tyrosine-protein kinase (EC 2.7.10.2) LCK Canis lupus familiaris (Dog) (Canis familiaris) Fc-gamma receptor signaling pathway [GO:0038094]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of T cell activation [GO:0050870]; response to xenobiotic stimulus [GO:0009410]; T cell differentiation [GO:0030217] cytosol [GO:0005829]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242] ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; SH2 domain binding [GO:0042169]; T cell receptor binding [GO:0042608] AAQIAEGMAFIEERNY;DDWMENIDVCENC 2 5.7 0.99035 -0.14717 0 0 0 0 0 0 7.89197 0 0 0 0 0 0 9.29048 0 A0A8I3NAD0 A0A8I3NAD0_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;LKKKTISGGITRPD;MDAFLESHKL 3 3 0.93925 0.06096 0 0 7.90153 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAD1 A0A8I3NAD1_CANLF Opioid receptor delta 1 OPRD1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adult locomotory behavior [GO:0008344]; cellular response to hypoxia [GO:0071456]; cellular response to toxic substance [GO:0097237]; negative regulation of gene expression [GO:0010629]; negative regulation of protein-containing complex assembly [GO:0031333]; neuropeptide signaling pathway [GO:0007218]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of mitochondrial membrane potential [GO:0051881] neuron projection [GO:0043005]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886] G protein-coupled enkephalin receptor activity [GO:0038046]; neuropeptide binding [GO:0042923] CWAPIHIFVIV;VLSIDYYNMFTSI 2 6.5 0.9917 -0.54448 0 0 0 9.42895 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAD5 A0A8I3NAD5_CANLF Family with sequence similarity 222 member B FAM222B Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] APSTLAHPQAQALARQQALQHA;PNGHYFQPLWNNI;PVASQNSLMQT 3 8.2 0.98723 -0.33748 0 9.06067 0 0 0 0 0 0 0 0 0 0 8.45984 10.9848 0 A0A8I3NAE0 A0A8I3NAE0_CANLF Bile acid-CoA:amino acid N-acyltransferase LOC481634 Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637] thiolester hydrolase activity [GO:0016790] RLRHYKGDPWDELNQQSVL 1 5.1 0.9881 -0.22449 0 0 0 0 0 11.7825 0 0 0 0 0 0 0 0 0 A0A8I3NAE6 A0A8I3NAE6_CANLF Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) GCLC Canis lupus familiaris (Dog) (Canis familiaris) glutathione biosynthetic process [GO:0006750] ATP binding [GO:0005524]; glutamate-cysteine ligase activity [GO:0004357] EVQLTDFENSAY;VLSGEEVLETLQEK 2 4.3 0.99421 -0.080426 14.1858 8.58635 0 0 15.3538 0 0 0 0 0 0 0 0 0 0 A0A8I3NAF1 A0A8I3NAF1_CANLF Olfactory receptor OR13E1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DISLNALLIMVAT;PMYFFLSNLSLMD 2 7.3 0.99229 -0.16724 0 0 6.93369 0 0 0 0 11.4072 0 0 0 0 0 0 0 A0A8I3NAG3 A0A8I3NAG3_CANLF EMAP like 2 EML2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] mitotic spindle [GO:0072686] microtubule binding [GO:0008017] DTETHDLVAIHTDGN;EQISVVSFSPD;GTLVSGGG;SGRSARRYLSPE 4 6 0.99619 -0.091768 0 0 0 0 0 0 0 5.30852 0 0 0 0 10.0863 0 0 A0A8I3NAG5 A0A8I3NAG5_CANLF Olfactory receptor LOC485224 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NPIIYGVKTKQ;RLTFCRNNILPH;SYIFALLGNGLLIFIILTKS 3 13.6 0.9323 0.099222 0 0 5.84997 0 0 8.38284 0 0 0 0 0 0 0 0 0 A0A8I3NAH1 A0A8I3NAH1_CANLF Sestrin 2 SESN2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TORC1 signaling [GO:1904262]; regulation of response to reactive oxygen species [GO:1901031] cytoplasm [GO:0005737]; nucleus [GO:0005634] GGGGGGGG;GGGGGGPG;GVDTSMLRRAIWNY;NLFWRHFRHSEKVDCLEAEAAKD;PGGGGGGG;PPTFRAQD;SEKVDCLEAEAAKDRSQALSV;VLLTHCHSLASFVF 8 16.5 1.0026 -1.4837 8.92279 0 0 0 0 15.7182 0 0 0 0 0 0 9.15954 0 0 A0A8I3NAH3 A0A8I3NAH3_CANLF CKLF like MARVEL transmembrane domain containing 1 CMTM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PAKAPAKAPAK;PKGILKILRLGLILGALI;SPKGILKILRLGLILGALI 3 7.2 0.9891 -0.20387 0 0 0 5.87216 3.81034 0 8.02026 0 0 0 0 0 0 0 0 A0A8I3NAH6 A0A8I3NAH6_CANLF UDP-glucose glycoprotein glucosyltransferase 2 UGGT2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum lumen [GO:0005788]; protein-containing complex [GO:0032991] UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980] AADGITGP;FQYELVQYRW;IYKQTESPYSYYNL;LPVTILYAEIGTRAFGK 4 3.2 1.0029 -0.782 0 0 0 0 11.3188 0 0 0 0 0 9.59231 10.1092 0 0 0 A0A8I3NAI6 A0A8I3NAI6_CANLF Tripeptidyl-peptidase 1 (EC 3.4.14.9) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) TPP1 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; proteolysis [GO:0006508] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240] PHVHTVSY;SLDVEYLMSAGANI 2 4.7 1.0021 -1.2965 0 0 0 8.65209 0 0 0 0 10.2512 0 0 0 0 0 0 A0A8I3NAI9 A0A8I3NAI9_CANLF Chromosome 8 open reading frame 82 C8orf82 Canis lupus familiaris (Dog) (Canis familiaris) GGGGDVPY 1 3.8 1.003 -1.1044 0 0 0 0 9.64918 0 0 0 0 0 0 0 0 0 0 A0A8I3NAJ9 A0A8I3NAJ9_CANLF nucleoside-diphosphate kinase (EC 2.7.4.6) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane-bounded organelle [GO:0043227] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524] GVLESFSG;RDDIWLLD 2 8.6 1.0034 -2.2088 0 0 0 10.0336 0 0 0 9.12709 0 0 0 0 0 0 0 A0A8I3NAL3 A0A8I3NAL3_CANLF ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) PCYT2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylethanolamine biosynthetic process [GO:0006646] ethanolamine-phosphate cytidylyltransferase activity [GO:0004306] GAGAPCGC;GGGGGGGG 2 3.3 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 3.59467 0 0 0 0 0 A0A8I3NAL4 A0A8I3NAL4_CANLF Inhibin subunit beta E INHBE Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083]; hormone activity [GO:0005179] SGCPSCGG 1 2.3 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 10.2283 0 0 0 8.91964 0 A0A8I3NAL5 A0A8I3NAL5_CANLF HEAT repeat containing 9 HEATR9 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244] IDPWIRNKLKNKVL;KTQQMKALRMLVKMM;LSSAFLPHFSKPKH;RDHPRQLKED;SKPSDPTGD 5 10.7 1.0044 -2.0045 10.0118 0 0 0 7.06426 6.90617 0 0 0 0 0 0 0 0 0 A0A8I3NAL7 A0A8I3NAL7_CANLF Coiled-coil domain containing 28B CCDC28B Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centrosome [GO:0005813] EEEEEDGV;EEEEEEEDGVTE;KKKKRSPKPCLTQPA;MADRNLDQLLS 4 19 0.9866 -0.23303 0 0 0 0 0 0 5.27761 0 0 0 7.18854 0 0 0 8.30611 A0A8I3NAN6 A0A8I3NAN6_CANLF Stimulated by retinoic acid 8 STRA8 Canis lupus familiaris (Dog) (Canis familiaris) activation of meiosis [GO:0090427]; cellular response to retinoic acid [GO:0071300]; male germ-line stem cell asymmetric division [GO:0048133]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673] protein dimerization activity [GO:0046983] AEGEEEEEEEEEDQDEEEE;AEGEEEEEEEEEDQDEEEEEEEEE;EEEEEEEEEEEEEEEEEEKK;EEEEEEEEEEEEEK;GEEEEEEEEEDQDEEEEEEEEEEEE;KDAEGEEEEEEEEEDQDEE 6 10.8 0.79365 0.22387 0 0 0 6.33548 0 5.17441 5.80808 6.10666 0 0 0 0 0 3.88675 0 A0A8I3NAP6 A0A8I3NAP6_CANLF EF-hand domain containing 1 EFHC1 Canis lupus familiaris (Dog) (Canis familiaris) cerebral cortex cell migration [GO:0021795]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302] axonemal microtubule [GO:0005879]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922] alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509] ERFFKICDSLNLPIDDSLIKE;FTEAKERPWSVEQELSKQTREDPP;HQEIKNVAQLPDYPELS;TVEIREVHERN;YYYLEDDSMSVMEPVVENSGIPQG 5 14.1 0.97358 0.036902 9.08226 0 4.88435 0 0 10.971 0 8.31316 0 0 8.44211 8.43725 10.2451 0 0 A0A8I3NAQ5 A0A8I3NAQ5_CANLF Huntingtin associated protein 1 HAP1 Canis lupus familiaris (Dog) (Canis familiaris) anterograde axonal transport [GO:0008089]; cerebellum development [GO:0021549]; hypothalamus cell differentiation [GO:0021979]; neurogenesis [GO:0022008]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of neurogenesis [GO:0050769]; positive regulation of non-motile cilium assembly [GO:1902857]; protein localization [GO:0008104]; regulation of exocytosis [GO:0017157]; regulation of organelle transport along microtubule [GO:1902513]; vesicle transport along microtubule [GO:0047496] autophagosome [GO:0005776]; axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; inclusion body [GO:0016234]; mitochondrion [GO:0005739]; nucleolus [GO:0005730] DSEEEEEEEEEEGEEEEEEEEEEE;EEEEEEEEEEQHDHPYGASELTS;EVLALRMESHDQQRRE;FFMERNHGTT;LVSEETEAWEEVEPQLDETTKQT;MLTEAQEEVKTLRQ;QEEVKTLRQQASVSTGPVTHYT 7 18.8 1.0016 -0.91684 6.07395 7.90509 0 0 0 9.20208 7.8885 0 7.81801 10.0627 0 6.13066 8.30665 0 0 A0A8I3NAR5 A0A8I3NAR5_CANLF Olfactory receptor OR6M2B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLEDKKTISFAGCM;NIFMYVRP 2 7 0.98987 -0.20246 0 0 0 0 0 7.42568 0 0 0 0 0 9.02353 0 0 0 A0A8I3NAR8 A0A8I3NAR8_CANLF Molecule interacting with CasL protein 1 (EC 1.14.13.225) (EC 1.6.3.1) MICAL1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoskeleton [GO:0005856]; endosome membrane [GO:0010008]; midbody [GO:0030496] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] EKQWHLDQELRGYLNQEGALKTPAD;SSSEEEEEEEEAAAGE 2 3.9 0.96011 0.049233 0 0 0 0 0 0 0 6.17682 0 0 0 0 0 0 0 A0A8I3NAS0 A0A8I3NAS0_CANLF Leucine rich repeat containing 1 LRRC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] IGKLKKLSI;LDVAGNRLLHLPLSLTALKLKAL;VPEEIYRYARSLEELLLDAN 3 9.9 0.98366 -0.24771 0 0 0 0 0 0 8.14389 0 0 0 0 0 0 0 0 A0A8I3NAS3 A0A8I3NAS3_CANLF SH3 domain binding glutamate rich protein like 2 SH3BGRL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] SH3 domain binding [GO:0017124] LAPRARGLKTA 1 3.5 0.98533 0.035491 0 10.3115 0 0 0 0 0 0 0 0 0 7.74005 0 0 0 A0A8I3NAS8 A0A8I3NAS8_CANLF Transmembrane protein 217 TMEM217 Canis lupus familiaris (Dog) (Canis familiaris) YAHIIYKSQSQGTI 1 7.3 0.93805 0.060892 0 0 0 6.92029 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAT2 A0A8I3NAT2_CANLF BRCA2 and CDKN1A-interacting protein Canis lupus familiaris (Dog) (Canis familiaris) spindle pole [GO:0000922] DEDEGESDEDEDGD;GLASAFGPGHEDEDEGESDE 2 9.9 0.97266 0.048206 0 4.14266 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAU9 A0A8I3NAU9_CANLF PX domain-containing protein SNX3 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; late endosome to Golgi transport [GO:0034499] early endosome membrane [GO:0031901]; retromer complex [GO:0030904] phosphatidylinositol-3-phosphate binding [GO:0032266] EIRVKTNLPIFKLKESTVRRRYS;HLKFSQQNLFSQWL 2 21.3 0.9311 0.10702 0 0 7.38198 0 0 0 0 0 5.48256 0 0 0 0 0 0 A0A8I3NAV2 A0A8I3NAV2_CANLF Ankyrin repeat and SOCS box containing 10 ASB10 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] HGRRSSPP;VDGRSEEEEETPL 2 4.6 0.989 -0.51847 0 0 0 0 0 0 0 0 13.3939 0 7.61139 0 0 0 0 A0A8I3NAW6 A0A8I3NAW6_CANLF Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) LOC119881670 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GGGGGGRH;VLHRDIKDENIL 2 3.7 0.99218 -0.17673 0 0 0 0 0 10.5702 0 0 0 0 0 0 0 0 0 A0A8I3NAW7 A0A8I3NAW7_CANLF Alpha-amylase (EC 3.2.1.1) LOC119881527 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] alpha-amylase activity [GO:0004556]; metal ion binding [GO:0046872] ENGKDVNDWYGPPN;PYGFTRVMSSFR;RNMVMFRNVVDGQPFTNWWDNG 3 9.7 0.99073 -0.19545 12.6491 0 0 0 0 0 6.20939 0 0 0 0 0 0 0 0 A0A8I3NAX8 A0A8I3NAX8_CANLF Uromodulin UMOD Canis lupus familiaris (Dog) (Canis familiaris) antibacterial innate immune response [GO:0140367]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated protein folding [GO:0061077]; citric acid secretion [GO:0046720]; collecting duct development [GO:0072044]; connective tissue replacement [GO:0097709]; defense response to Gram-negative bacterium [GO:0050829]; endoplasmic reticulum organization [GO:0007029]; ERAD pathway [GO:0036503]; glomerular filtration [GO:0003094]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; intracellular chloride ion homeostasis [GO:0030644]; intracellular phosphate ion homeostasis [GO:0030643]; intracellular sodium ion homeostasis [GO:0006883]; juxtaglomerular apparatus development [GO:0072051]; leukocyte cell-cell adhesion [GO:0007159]; lipid metabolic process [GO:0006629]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; micturition [GO:0060073]; multicellular organismal response to stress [GO:0033555]; neutrophil migration [GO:1990266]; organ or tissue specific immune response [GO:0002251]; potassium ion homeostasis [GO:0055075]; protein localization to vacuole [GO:0072665]; protein transport into plasma membrane raft [GO:0044861]; regulation of blood pressure [GO:0008217]; regulation of protein transport [GO:0051223]; regulation of urine volume [GO:0035809]; renal sodium ion absorption [GO:0070294]; renal urate salt excretion [GO:0097744]; renal water homeostasis [GO:0003091]; response to lipopolysaccharide [GO:0032496]; response to water deprivation [GO:0009414]; response to xenobiotic stimulus [GO:0009410]; RNA splicing [GO:0008380]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; urate transport [GO:0015747]; urea transmembrane transport [GO:0071918] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; ciliary membrane [GO:0060170]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; side of membrane [GO:0098552]; spindle pole [GO:0000922] calcium ion binding [GO:0005509]; IgG binding [GO:0019864] ATPSSNATDPLKYFIIQDRCPRTT;EDCKSHDGMWSCQCKQDFN;PSPIPVIA;SECHSNATCMEDGMVTTCSCLV 4 11.3 1.0041 -1.1044 0 0 9.28161 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NAY5 A0A8I3NAY5_CANLF Plexin domain containing 2 PLXDC2 Canis lupus familiaris (Dog) (Canis familiaris) RRCHPSLRAPHCWE;SLNRRCHPS;TALVVQWDHVHLQDNYN;VGEKEGFIVSE;VGLSDAFVVV 5 12.6 1.0042 -1.0893 0 0 0 0 13.0534 0 0 9.12138 0 0 0 0 0 0 9.06164 A0A8I3NAY6 A0A8I3NAY6_CANLF 52 kDa repressor of the inhibitor of the protein kinase THAP12 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] MKVENERYENGRKR;REVRDSHFFSIITDDVVD 2 5.5 0.90416 0.12292 0 0 0 0 0 0 0 0 5.00072 0 0 0 0 8.56784 0 A0A8I3NAZ5 A0A8I3NAZ5_CANLF RASD family member 2 RASD2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EAELLVSGDENCAYFEVSAKKNT 1 8.6 0.97864 0.046253 0 0 0 0 0 0 0 0 0 0 8.31066 0 0 0 0 A0A8I3NAZ8 A0A8I3NAZ8_CANLF Potassium channel subfamily K member 9 KCNK9 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; stabilization of membrane potential [GO:0030322] plasma membrane [GO:0005886] outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841] EEISPSTL;GGGGGGGG;PQDYGGRPVAQQN 3 6.4 1.002 -1.3632 8.63941 0 0 0 0 0 0 0 0 0 0 6.87652 0 0 0 A0A8I3NB02 A0A8I3NB02_CANLF Ring finger protein 44 RNF44 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ELQDQMFSYPFGPG;HDPLHQELSFG;PQVLGQKMELQ 3 7.1 0.92775 0.096429 0 0 0 0 6.13553 0 0 0 0 8.42122 7.71005 7.85162 0 7.81051 0 A0A8I3NB19 A0A8I3NB19_CANLF Cardiotrophin like cytokine factor 1 CLCF1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] CNTFR-CLCF1 complex [GO:0097059]; CRLF-CLCF1 complex [GO:0097058] cytokine activity [GO:0005125] EKNLRVGLADGIIKAS;KKKKKKKSLQNVPHR;LQFVVTALHVRKKKKKKK;VPHRKKKK;VRKKKKKKKS;VTALHVRKKKKKKK;WRSAKDFNRLKKKM 7 17 1.0024 -1.7514 9.33362 0 3.90014 0 4.62947 0 0 0 0 5.19743 8.82451 7.10224 0 0 10.7822 A0A8I3NB31 A0A8I3NB31_CANLF Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1) GLMP Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] PPYSLAEF;VGTPPVDA 2 5 1.0022 -1.3666 11.4947 0 0 0 0 0 0 0 0 0 0 0 9.03364 0 0 A0A8I3NB36 A0A8I3NB36_CANLF Golgi membrane protein 1 GOLM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NYGKLQQDVFQFQR 1 3.4 0.93735 0.060873 0 0 0 0 0 0 8.64987 0 0 0 0 0 0 0 0 A0A8I3NB44 A0A8I3NB44_CANLF Olfactomedin 3 OLFM3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular space [GO:0005615]; synapse [GO:0045202] NQDTLEVMKSWS;STKTSTYEYT;VLAQRSLE 3 6.6 1.0042 -1.0852 0 10.0139 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NB50 A0A8I3NB50_CANLF ZXD family zinc finger C ZXDC Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ALCPGGDT;FITVSALFSHN;GVAAGASDEALNSG;NAGGASCS;PGAGASPP 5 5.8 1.0032 -2.2088 0 0 0 0 0 8.99582 0 0 0 0 0 0 0 0 0 A0A8I3NB52 A0A8I3NB52_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) meiotic DNA double-strand break formation [GO:0042138] AALCPCPKVFSNQ 1 7.4 0.9391 0.059596 0 0 0 8.52931 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NB54 A0A8I3NB54_CANLF Transcription factor SOX-10 SOX10 Canis lupus familiaris (Dog) (Canis familiaris) cell maturation [GO:0048469]; central nervous system myelination [GO:0022010]; developmental growth [GO:0048589]; digestive tract morphogenesis [GO:0048546]; enteric nervous system development [GO:0048484]; in utero embryonic development [GO:0001701]; lacrimal gland development [GO:0032808]; melanocyte differentiation [GO:0030318]; morphogenesis of a branching epithelium [GO:0061138]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; peripheral nervous system development [GO:0007422]; positive regulation of gliogenesis [GO:0014015]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366] mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPSLPPSP;GGGGGGSG;PDGGGGGGGS 3 3.2 1.0029 -1.3797 0 0 0 0 0 0 0 6.08801 0 0 0 0 0 0 8.01184 A0A8I3NB61 A0A8I3NB61_CANLF Leucine rich repeat neuronal 1 LRRN1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of synapse assembly [GO:0051965] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; membrane [GO:0016020] QNNFTNIKEVGLANLTQ 1 2.4 0.98436 0.046227 0 0 0 0 0 0 6.804 0 0 0 0 0 0 0 0 A0A8I3NB65 A0A8I3NB65_CANLF Apical junction component 1 homolog AJM1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell junction organization [GO:0045216] DALARTYPHPRSSPAWVDWGL;PAPHVRCRLDIKPD;PSADEDDLMT;SCYTYYCSRL 4 5.6 1.0022 -0.7635 10.1463 0 0 0 0 7.29646 0 0 0 0 0 9.67828 0 0 0 A0A8I3NB71 A0A8I3NB71_CANLF Guanylate cyclase activator 2B GUCA2B Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] guanylate cyclase activator activity [GO:0030250] LLLLLLLL;LSRVAVVHLLLLLLLL;SRVAVVHLLLLLLLLQ;VSGLLSRVAVVHLLLLLLLLQ;VVHLLLLLLL;VVHLLLLLLLL 6 18.1 0.98552 -0.43033 0 0 5.57374 4.72028 5.2225 0 0 0 0 0 4.77979 0 0 6.71287 5.5451 A0A8I3NB74 A0A8I3NB74_CANLF Uncharacterized protein PGBD2 Canis lupus familiaris (Dog) (Canis familiaris) HAKCFREYH;LFFDEGTINFIV;LSILKKKGV;PVGLFELFFDEGT 4 6 1.002 -1.2478 0 0 0 0 0 8.42978 0 10.8403 0 0 0 4.18959 0 0 0 A0A8I3NB77 A0A8I3NB77_CANLF Post-GPI attachment to proteins GalNAc transferase 4 PGAP4 Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] GFHYVLQVVSQFHRLL 1 4 0.96077 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 5.36859 0 0 A0A8I3NB81 A0A8I3NB81_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) CSF1R Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cytokine-mediated signaling pathway [GO:0019221] plasma membrane [GO:0005886] ATP binding [GO:0005524]; cytokine binding [GO:0019955]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] LLLLLLLL;LLLLLLLLL;LLLLLLLLLF;NSSQAFRPISI;QLPYNEKWEFPRNNLQ;VLLLLLLLL;VLLLLLLLLLFYKYKQKPK 7 4.7 0.20833 0.74009 0 0 6.17173 5.93152 0 0 9.2248 0 0 0 0 0 0 0 0 A0A8I3NB85 A0A8I3NB85_CANLF Olfactory receptor LOC119864931 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVPGLEWAHAWISIPFCCLYL;KQIQKAVLKLVCSK;SLHEPMYYFLSM;VLGIFWLNAREISFNA 4 20.1 0.98653 -0.38507 7.98533 0 0 0 0 0 0 8.71994 0 0 0 0 0 0 10.3476 A0A8I3NB89 A0A8I3NB89_CANLF StAR related lipid transfer domain containing 10 STARD10 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] lipid binding [GO:0008289] AASTLPEPPRRT 1 3.6 0.98235 -0.25107 0 0 0 0 0 0 0 0 9.03119 0 0 0 0 0 0 A0A8I3NB90 A0A8I3NB90_CANLF TTK protein kinase TTK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CQLSTPYSQLAHFQQQQ;DYGKTDGSVLPSFTKRQT;PLNDALLNKLIGRYSQ 3 6 0.9933 -0.14311 5.30601 0 0 0 0 0 0 0 0 0 0 0 0 0 7.26068 A0A8I3NB91 A0A8I3NB91_CANLF "Cyclic nucleotide-gated channel alpha-1 (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated cation channel subunit alpha) (cGMP-gated cation channel alpha-1)" CNGA1 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886] calcium channel activity [GO:0005262]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; protein-containing complex binding [GO:0044877] FGRLARKYVYSL;GYSDLFCL;MEKRVIKW 3 4.1 0.98778 -0.46014 0 0 0 0 0 0 0 6.11971 0 0 0 0 0 0 0 A0A8I3NB97 A0A8I3NB97_CANLF Suppressor of tumorigenicity 7 protein ST7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EQLKSCIVWSWTYLWT;EVSVYPKKEL;GVDNNSSNNSNSSNGDSDS;KYGTSFIEQVSVSHL;QLGRAGPG;VLAKYDDIS;VLFLVYVLRVPL 7 16.2 1.0036 -1.1044 0 0 0 0 0 0 10.8442 0 0 0 0 0 0 0 0 A0A8I3NBA8 A0A8I3NBA8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAP4K4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLVKNTKGNTLKEDWIAYIS;EARRQQEREQRRRE;FFASVRSGG;FIGTPYWMAPE;GSCAGFHAVDVDSGSVYDIY;IDRTRKKRGEKDE;KKFFSFIE;PQSDTPEIRKY;SSSEESGTTDEEDDDVEQEG;TPSKEGTLIVRQTQ 10 12 0.98389 -0.24474 0 0 0 0 0 0 0 0 0 0 0 0 10.809 0 0 A0A8I3NBE3 A0A8I3NBE3_CANLF Formin homology 2 domain containing 1 FHOD1 Canis lupus familiaris (Dog) (Canis familiaris) AADHNYQSYILR;DPELSLEEQRE;GPALSSGQAPSP;LEEQREML 4 3.3 1.003 -1.6263 0 9.75741 0 0 0 0 0 0 0 0 0 10.3893 0 0 7.04472 A0A8I3NBE4 A0A8I3NBE4_CANLF RAD50 double strand break repair protein RAD50 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; telomere maintenance [GO:0000723] "chromosome, telomeric region [GO:0000781]; Mre11 complex [GO:0030870]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872] DEDFVELLGRSEYVE;DLDRTVQQVN;FYRIKKNIDQCSEIV;IIHFKRELREPQFRDAEEKHREMMI;RNFQLLVITHDEDFV;VMRTTELVNKDLDIYYK 6 7.2 1.0029 -0.9763 10.7267 6.0247 9.533 0 0 0 0 0 0 0 0 8.77007 0 6.43833 0 A0A8I3NBE5 A0A8I3NBE5_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) LOC119874465 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] DTLGPNTQ;KPAKPLPKE;VINNPSYKENAMKLSRI 3 6.9 0.99238 -0.18682 0 0 0 0 0 11.6308 0 0 0 0 0 0 0 10.179 0 A0A8I3NBE7 A0A8I3NBE7_CANLF Zinc finger and BTB domain containing 39 ZBTB39 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ESTAVAKPLSGTGE 1 2 0.98901 -0.21821 0 0 0 0 0 10.4321 0 0 0 0 0 0 0 0 0 A0A8I3NBF1 A0A8I3NBF1_CANLF RNA binding motif protein 25 RBM25 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]" nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729] EKEKERERERERDRDRDRTKER;EKSRDRERERERERERERERERERE;EREREREREREKEKERERERERDRD;EREREREREREREREREREKDKK;KFEDEDSDDVPRKRKLVPLDYGED;LAEGHPDPDAEL;PGTPMIPVPMSI 7 14.8 0.997 -0.59456 9.80344 0 0 0 8.64342 9.11158 10.0243 9.85328 10.8935 11.844 0 0 0 0 0 A0A8I3NBF7 A0A8I3NBF7_CANLF Basic proline-rich protein-like Canis lupus familiaris (Dog) (Canis familiaris) ANRGLASP;DTLRGGERRGKKKKKK;ERRGKKKKKKKK;KKKKKKKK;RGGERRGKKKKKKKK;RGKKKKKKKKKS;RRGKKKKKKKKK;RRGKKKKKKKKKSQLPV;TLRGGERRGKKKKKKKKKSQ 9 5.9 1.0037 -1.0544 7.40037 0 0 5.68493 0 0 11.151 0 0 2.77119 0 8.42358 0 3.11463 0 A0A8I3NBG0 A0A8I3NBG0_CANLF Dipeptidase (EC 3.4.13.19) DPEP2 Canis lupus familiaris (Dog) (Canis familiaris) leukotriene D4 catabolic process [GO:1901749]; proteolysis [GO:0006508] side of membrane [GO:0098552] metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573] EASKGQRPLEDEFP;LERTPAPRGPPLRRLLLVLLL;PLRRLLLVLLLP;PLRRLLLVLLLPRLVS;RRLLLVLLLPRLV 5 8.6 0.69108 0.26749 0 0 0 7.08576 7.3419 0 0 0 0 0 0 0 0 9.28269 4.93442 A0A8I3NBG5 A0A8I3NBG5_CANLF Zinc finger protein 830 (Coiled-coil domain-containing protein 16) ZNF830 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst growth [GO:0001832]; cell division [GO:0051301]; chromosome organization [GO:0051276]; intestinal epithelial structure maintenance [GO:0060729]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic DNA replication checkpoint signaling [GO:0033314]; negative regulation of apoptotic process [GO:0043066]; nuclear DNA replication [GO:0033260]; preantral ovarian follicle growth [GO:0001546]; RNA processing [GO:0006396] chromosome [GO:0005694]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] DYEDEEEEEEEEE;DYEDEEEEEEEEEEEGGGGK;EDEEEEEEEEEEEGGG;LPDYEDEEEEEEEEEEE 4 5.9 0.99673 -0.096467 0 13.0288 0 0 0 3.03481 0 0 0 14.8551 0 4.65208 0 12.9169 12.7774 A0A8I3NBG9 A0A8I3NBG9_CANLF Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) COG8 Canis lupus familiaris (Dog) (Canis familiaris) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119] IHRLFGDVESSLG;RERPDVGRYLREL;VFLEDLVPYL 3 5.8 0.99236 -0.042698 0 11.3065 0 5.69877 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NBH4 A0A8I3NBH4_CANLF Armadillo repeat containing 2 ARMC2 Canis lupus familiaris (Dog) (Canis familiaris) GLRVSTHALQAGGGGGEGGRRAG;LRALHLPARGLRVSTHALQAGGG 2 11.1 0.93658 0.092704 5.3896 0 0 0 0 0 0 0 6.95093 0 0 0 0 0 0 A0A8I3NBH7 A0A8I3NBH7_CANLF C-C motif chemokine receptor like 2 CCRL2 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] plasma membrane [GO:0005886] CCR chemokine receptor binding [GO:0048020]; chemokine receptor activity [GO:0004950] LLVVLILVK;LVVLILVKHKGL;LVVLILVKHKGLKHMGN;SLLVVLILVKHKGLK 4 5.4 1.0031 -1.0283 0 0 0 0 4.41779 5.3365 0 6.24531 0 3.52644 4.76527 0 0 4.50722 0 A0A8I3NBH8 A0A8I3NBH8_CANLF Nuclear mitotic apparatus protein 1 NUMA1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] AEELGQELKAWQ;DQAREKYGQ;FLSGSPASPMGDILQ;KTKEAEQTCRH;QLSELQAQLNQKEQAAEHYKLQM;QQPVPERLEFV;QVAHADQQLRD;REAEGECEQ;VASSSGNNFLSGSPA;VLETEQAQWENKLLAEQGRFEE;YSTQSAPASQAGPRATS 11 7 1.0033 -1.5001 0 13.8655 0 7.21684 6.77873 8.14328 9.68242 0 9.37136 9.87284 10.2541 0 13.5597 11.3016 0 A0A8I3NBJ7 A0A8I3NBJ7_CANLF Uncharacterized protein REPIN1 Canis lupus familiaris (Dog) (Canis familiaris) FAQWDQLVAHKRV;LHGLQAEEEPMLE;SQGSHLAAHRRDHAPE;TECGRRFRH 4 8.2 1.002 -0.74118 0 0 0 0 4.24115 0 10.5622 0 12.6805 0 0 0 0 4.49825 0 A0A8I3NBK2 A0A8I3NBK2_CANLF Olfactory receptor OR13C4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFLVLPLLVI;MVYVLMASVS 2 6.3 0.98764 -0.50393 0 0 0 10.2689 0 0 0 0 0 0 4.10618 0 0 0 0 A0A8I3NBK9 A0A8I3NBK9_CANLF Mitogen-activated protein kinase kinase kinase 19 MAP3K19 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EESILWTKGEILGKGAYGTVY;NEANSISQETLD;PKELAIAKPS;SIWSRNMCSFWEANHHRPHME;SNEEFDQDEDCS;TVFEMATGKPP 6 6.3 1.0029 -0.85677 0 9.73579 0 0 0 8.76504 0 0 13.7162 0 0 0 0 0 9.06474 A0A8I3NBM3 A0A8I3NBM3_CANLF Tyrosine-protein kinase (EC 2.7.10.2) TEC Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; regulation of platelet activation [GO:0010543] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] FMRELGSGLFG;LFGVVRLGKWRAQYKVAI;SRDMLLSMCQDVCEGM;YVLDDQYTSSSGAKFPV 4 9.4 0.98503 -0.44779 0 0 0 5.84079 0 0 0 9.93561 0 0 0 2.65485 0 0 0 A0A8I3NBM8 A0A8I3NBM8_CANLF Protein LLP homolog (Protein LAPS18-like) LLPH Canis lupus familiaris (Dog) (Canis familiaris) dendrite extension [GO:0097484] nucleolus [GO:0005730] basal RNA polymerase II transcription machinery binding [GO:0001099]; RNA binding [GO:0003723] KMDSDVLMKDV;PGTAGSARREAS;RAVTGLRVSRF 3 12.5 0.98801 -0.34822 10.9052 0 0 0 0 0 10.4307 0 0 0 10.8467 0 11.0845 15.4256 12.0105 A0A8I3NBP1 A0A8I3NBP1_CANLF Uncharacterized protein STK38 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EKVMEEEGLKDEEKR;PPRRGAVTPAQ;SLWVVKMFYSF 3 6.3 0.99318 -0.17469 0 0 0 0 9.0604 0 8.46842 0 8.17053 0 0 0 0 0 0 A0A8I3NBP6 A0A8I3NBP6_CANLF Sulfatase modifying factor 1 SUMF1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] LHRPDHPVLHVSWNDAVAYCTWA;VLIPAGVFTMGTDDP;YLTEVAAAPWWL 3 14.3 0.99147 -0.29297 0 0 0 0 0 0 0 0 0 0 0 0 0 13.1113 8.57031 A0A8I3NBP8 A0A8I3NBP8_CANLF Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein LOC119876970 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLVIKFILI 1 3 1.0036 -0.80421 0 5.29381 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NBP9 A0A8I3NBP9_CANLF Parkin coregulated like PACRGL Canis lupus familiaris (Dog) (Canis familiaris) ITSALQQLEQHGGNGSL;LFHLFFVHLLCF;PSAFAAIY;VGPSLNDHL 4 18.5 1.002 -1.2193 10.4285 0 0 0 0 8.95751 0 0 0 0 0 0 0 7.44186 0 A0A8I3NBQ2 A0A8I3NBQ2_CANLF Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) Canis lupus familiaris (Dog) (Canis familiaris) IMP salvage [GO:0032264]; purine ribonucleoside salvage [GO:0006166] cytoplasm [GO:0005737] hypoxanthine phosphoribosyltransferase activity [GO:0004422]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] MASRSPSIVISDD;VGYALDYNEYFR 2 11.5 0.91773 0.11003 8.29375 0 0 5.82003 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NBQ7 A0A8I3NBQ7_CANLF peptidylprolyl isomerase (EC 5.2.1.8) AIP Canis lupus familiaris (Dog) (Canis familiaris) protein maturation by protein folding [GO:0022417]; protein targeting to mitochondrion [GO:0006626]; xenobiotic metabolic process [GO:0006805] aryl hydrocarbon receptor complex [GO:0034751]; cytosol [GO:0005829]; plasma membrane [GO:0005886] aryl hydrocarbon receptor binding [GO:0017162]; GAF domain binding [GO:0036004]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription coregulator activity [GO:0003712]; unfolded protein binding [GO:0051082] IVSTMREGEIA;SSLGHADL 2 5.8 1.0039 -1.0689 0 0 0 0 0 0 0 10.0918 0 0 0 0 0 10.0278 0 A0A8I3NBR0 A0A8I3NBR0_CANLF Supervillin SVIL Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; skeletal muscle tissue development [GO:0007519] actin cytoskeleton [GO:0015629]; costamere [GO:0043034]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin filament binding [GO:0051015] ASPHTGRSN;ESQMTIEERKHLITVRE;GLLAGDGLSDPDVLL;SEIPENISEY;SSSSGDFLATEFIYPARDPSV;TDHKFPSLMENSD;VLAGGDGGKKYGSF;VTLAQRKIAFQLAKHLWNGT 8 5.3 1.0026 -1.1481 10.0935 9.52591 0 0 9.84751 0 7.41557 7.25663 12.0975 5.68061 0 0 0 0 0 A0A8I3NBR3 A0A8I3NBR3_CANLF A-kinase anchoring protein 6 AKAP6 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of membrane repolarization [GO:0060306] calcium channel complex [GO:0034704]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum [GO:0016529] transmembrane transporter binding [GO:0044325] AEKQLQYFKSLCGEIKQ;CCDCEPDVFHQK;CFNYNEDSP;DDKSGCEESSAL;EACVEDDPDGDGPCL;FFEACVEDDPDGDGP;KTKPFDSWSY;PKESETLSSSRKKNSDTEHCK;SSEKIDSHSATKSAL;VGCVNGKVGDLNSI 10 5.5 1.0032 -1.618 10.1994 0 6.76726 6.8426 10.5087 8.01764 5.79189 0 7.57833 0 0 0 8.25517 0 0 A0A8I3NBR9 A0A8I3NBR9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TPCKVCCILLISESQKLAHYQ 1 18.3 0.94974 0.049735 0 0 0 0 0 0 0 0 0 0 0 8.5097 0 0 0 A0A8I3NBS0 A0A8I3NBS0_CANLF RNA-binding region-containing protein 3 RNPC3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] CISRRELE;EDCDEMPSECIS;LHLMNKMNLPTPF;NLQPKRPKA;SEYESSDD 5 9.4 1.0023 -1.8453 0 0 7.68748 0 0 0 0 7.31089 0 9.05675 0 0 0 0 7.10936 A0A8I3NBS2 A0A8I3NBS2_CANLF Transmembrane protein 14A TMEM14A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDSSFRIA;GLGQSPPP 2 6.7 1.0025 -1.3498 0 7.99724 0 0 0 0 0 5.11395 0 0 0 0 0 0 0 A0A8I3NBU0 A0A8I3NBU0_CANLF TATA-box binding protein associated factor 15 TAF15 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] GVSTDQVG;QGGRAPSYDQSDYGQQDSYD;SATDHTDDCFECS 3 7.7 1.0018 -1.2881 0 0 0 0 0 0 0 0 0 0 4.57453 8.72857 9.39225 0 0 A0A8I3NBU4 A0A8I3NBU4_CANLF Kinesin-like protein KIF5B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DLQDQNQKMMLEQERLRVEHEKLKA;EETVAKELQT;ESALKEAKENASRDRKRYQQ;HSAQIAKPIRPGQHPAASP;KNKTLRNTIQWLENELNRWRNGE;LDQEELLAS;SFLENNLE;SNTSQEQVYNDCAKKIVK 8 13.9 1.0019 -0.99333 6.67228 0 0 0 0 5.55462 8.76987 0 0 0 0 9.31829 8.61272 9.3728 0 A0A8I3NBU5 A0A8I3NBU5_CANLF Leucine rich repeats and death domain containing 1 LRRD1 Canis lupus familiaris (Dog) (Canis familiaris) EVKNCKKIT;LEYNQLTIFPKV;NYISEIPVDISFSKQL;QKGLGLESDN 4 5.4 1.0022 -0.763 0 0 0 9.61513 0 0 0 0 0 11.8476 8.58811 0 0 0 0 A0A8I3NBV1 A0A8I3NBV1_CANLF Multiple EGF like domains 10 MEGF10 Canis lupus familiaris (Dog) (Canis familiaris) CKNGALCNPITGACHC;CTRHRISYRTAYRH;DRSCQCYPGWIG;GAIVGIIILVLVVLFLLALFI;LVLVVLFLLALF;PCHLDNTHSCHPMSGEC;RWGPNCSLPCYCK;SACDGDHWGPHCSSRCQC;SHWESYSVTVQES;SLCLWSRTASALN;SSACDGDHWGPHC;VGIIILVLVVLFLL;VGIIILVLVVLFLLALFII;VGIIILVLVVLFLLALFIIYRQK;VGIIILVLVVLFLLALFIIYRQKQK;VLVVLFLLALFIIYRQKQK;YGLNCAERCDCSHADGCHSTT 17 15.1 1.0021 -0.65051 10.9916 9.1581 7.53029 12.4645 8.47638 7.94895 0 8.86836 6.09026 10.8619 10.2148 0 0 7.90244 6.32674 A0A8I3NBW9 A0A8I3NBW9_CANLF Chromodomain helicase DNA binding protein 1 like CHD1L Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787] EAARTRVEEQDLQQWGLTASELHK;EELEDRRKKRQEAAAK;GAGRSGGD;LMKDLDAFESEMA;QSFCLPSEESEPED 5 10.8 0.97403 0.041303 0 0 0 0 0 0 6.49414 0 0 0 0 0 0 0 0 A0A8I3NBX0 A0A8I3NBX0_CANLF Ring finger protein 121 RNF121 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] FKIKPEDAMDFG;HARMHAKHRGHEAMHA;LVAWQPVIIGL;VGKKQTCPYCKEK 4 17.6 0.98729 -0.40597 0 0 0 8.61622 7.02048 0 0 15.104 0 0 0 0 0 0 0 A0A8I3NBX4 A0A8I3NBX4_CANLF SH2 domain containing 3A SH2D3A Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] PGLAAVMGALLMPQV;RLLRTLHRARLVARDAPQ;VLSYVTGQRPLSQATGAVAS;WWEANEEEEEEDRSFARP 4 12.3 0.99438 -0.081179 11.7593 9.64476 0 0 11.2883 0 0 0 0 4.93692 0 0 0 0 0 A0A8I3NBY1 A0A8I3NBY1_CANLF Calcium binding protein 2 CABP2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LDRELRPEEIEELQ 1 6.4 0.98317 -0.25633 0 0 0 9.06482 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NBY4 A0A8I3NBY4_CANLF Keratin 36 KRT36 Canis lupus familiaris (Dog) (Canis familiaris) regulation of keratinocyte differentiation [GO:0045616] keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] ELNQQVVSSSE;PPVDLNKIL;VSSVRLGLSSLGSCL 3 7.5 0.98787 -0.49529 0 0 0 0 0 0 0 8.2254 0 0 0 0 0 0 10.0876 A0A8I3NBY9 A0A8I3NBY9_CANLF Uncharacterized protein ZPBP Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339] acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576] DTEKGPKPCVDHNCESSKRLSKAK;EPHYYYQFTA;QFTARYHAAPCNSIY;QLKYLIYAYREPHYYYQFTARYH 4 15.7 0.98579 -0.43253 0 0 0 0 0 0 0 0 8.79734 0 0 0 0 12.3952 8.90436 A0A8I3NBZ0 A0A8I3NBZ0_CANLF Vacuolar protein sorting-associated protein 28 homolog VPS28 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT I complex [GO:0000813]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130] LVQYKAAFRQ 1 4.5 0.98851 -0.26445 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.20016 A0A8I3NBZ1 A0A8I3NBZ1_CANLF "Proline rich 7, synaptic" PRR7 Canis lupus familiaris (Dog) (Canis familiaris) alpha-beta T cell differentiation [GO:0046632]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase I [GO:0006356]; T cell differentiation in thymus [GO:0033077] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] long-chain fatty acid binding [GO:0036041]; protein tyrosine kinase binding [GO:1990782]; ubiquitin-like protein ligase binding [GO:0044389] TDTRGLYRKI 1 3.7 0.99957 -0.61146 0 0 0 5.61753 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NBZ8 A0A8I3NBZ8_CANLF Protein phosphatase 1H (EC 3.1.3.16) PPM1H Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] protein serine/threonine phosphatase activity [GO:0004722] DHIARPILILKETRRLP;GGGGGSDLP;ISNDRLGSGDDISVYVI;VSCHYWSLFDGHAGS 4 11.3 0.98714 -0.4078 0 12.2301 0 0 0 0 0 10.9219 8.30342 0 9.52523 0 0 9.26379 0 A0A8I3NC01 A0A8I3NC01_CANLF Polyprenol reductase (EC 1.3.1.22) (EC 1.3.1.94) SRD5A3 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; polyprenol catabolic process [GO:0016095] endoplasmic reticulum membrane [GO:0005789] 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity [GO:0047751]; polyprenol reductase activity [GO:0102389] VLWNGFLLWHLTQSLF 1 5 0.99309 -0.13986 0 0 0 0 0 0 0 11.053 0 0 0 0 0 0 0 A0A8I3NC04 A0A8I3NC04_CANLF Platelet-derived growth factor C PDGFC Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; digestive tract development [GO:0048565]; fibroblast proliferation [GO:0048144]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730] cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803] HTYPRNMVLVWRLVAAEENVWIQL;LEDLIRYLEPD;LEDLYRPTWQL;SPRFPHTYPRNMV 4 14.8 1.0037 -0.80415 10.0737 0 0 0 0 0 0 0 0 0 0 0 0 9.78128 0 A0A8I3NC06 A0A8I3NC06_CANLF SH2 domain containing 3A SH2D3A Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] PGLAAVMGALLMPQV;RLLRTLHRARLVARDAPQ;TTAPYPVRARK;WWEANEEEEEEDRSFARP 4 12.9 0.98049 0.035491 0 0 9.89969 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NC38 A0A8I3NC38_CANLF R3H domain containing 1 R3HDM1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] IDLHEFLVNTLKNNP;ISQENQEKIQ;PTAAAATS;QEILDFIGNNESPR;VNKTSNTRIPDQKFNEH 5 6.3 0.98966 -0.26566 9.25231 0 8.95713 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NC42 A0A8I3NC42_CANLF "PYM homolog 1, exon junction complex associated factor" PYM1 Canis lupus familiaris (Dog) (Canis familiaris) "exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" cell junction [GO:0030054]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ribosome binding [GO:0043022] EKAKKIKNLKKKLRQVEELQQ;KAKKIKNLKKKLRQV 2 10.3 0.94118 0.10104 0 0 6.97591 0 0 0 0 9.14944 0 0 0 0 0 0 0 A0A8I3NC52 A0A8I3NC52_CANLF diacylglycerol O-acyltransferase (EC 2.3.1.20) DGAT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] O-acyltransferase activity [GO:0008374] EEEVRAAGPGA;RLFLENLIKYGILV 2 7.9 0.985 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 9.58323 0 A0A8I3NC60 A0A8I3NC60_CANLF Tectonin beta-propeller repeat-containing protein 1 TECPR1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome membrane [GO:0000421]; lysosomal membrane [GO:0005765] AGTKPPSL;DLSVGGWEITDEPVG;GLSPSVQTLSLSITPA;LEASEHMLP;LWEGQALVREGINRNNPKGSSWSI;QEGWQYASDFPASYHGYKTM;SENGIMHVSVGV;TAWVYTGGYGGGCFQ;VFQGWTYAID;WELCKDNRLEF 10 12.2 0.99121 -0.18584 0 0 0 0 0 0 9.86631 0 0 0 0 0 0 0 0 A0A8I3NC68 A0A8I3NC68_CANLF Annexin ANXA6 Canis lupus familiaris (Dog) (Canis familiaris) zymogen granule membrane [GO:0042589] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] DEYLRTTGKPIEA;TFKSHFGRDLMADLKSEISG 2 5.4 0.98866 -0.26246 0 0 0 0 0 0 0 0 9.98413 0 0 0 0 0 0 A0A8I3NC70 A0A8I3NC70_CANLF Kinesin-like protein KIF9 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EASQLEETL;EKYITSKINL;GPDSFSFYNAKVKTEQKHNYL;IPFRQCKLTHAL;LLILKLKDLKKQ;PSVTPMTIVEN 6 10.3 1.0022 -1.4248 0 0 10.1669 0 0 0 11.9942 0 0 9.62172 0 0 0 3.25887 0 A0A8I3NC75 A0A8I3NC75_CANLF Histidine triad nucleotide binding protein 2 HINT2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; negative regulation of peptidyl-lysine acetylation [GO:2000757] mitochondrion [GO:0005739] adenosine 5'-monophosphoramidase activity [GO:0043530] MGAQSVYHLHIH 1 7.4 0.95315 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 8.57554 0 0 A0A8I3NCA0 A0A8I3NCA0_CANLF Serine incorporator 1 (Tumor differentially expressed protein 2) SERINC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] ASLYIMMTLTNWYRYEPSREMKS;CCPSGNNS;SIRTSNNSQVNKL;SVITVYTMYLTWSAMTNEPE;WYRYEPSREMKSQWT 5 14.8 1.004 -1.1044 4.50684 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NCA2 A0A8I3NCA2_CANLF G protein-coupled receptor 152 GPR152 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802] DEDYYPQGGWDTVFLV;YSDYLILLNSCL 2 6 0.99089 -0.19595 0 0 4.94303 4.0343 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NCA6 A0A8I3NCA6_CANLF Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48) EIF3E EIF3S6 INT6 Canis lupus familiaris (Dog) (Canis familiaris) "formation of cytoplasmic translation initiation complex [GO:0001732]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; PML body [GO:0016605]; postsynaptic density [GO:0014069]" translation initiation factor activity [GO:0003743] SVELVRLFIFL;VECLYVNFDFD 2 4.8 0.98386 0.035491 0 0 0 5.93192 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NCA9 A0A8I3NCA9_CANLF Fizzy and cell division cycle 20 related 1 FZR1 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of cell population proliferation [GO:0008284]; regulation of meiotic nuclear division [GO:0040020] nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] anaphase-promoting complex binding [GO:0010997]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027] AGANWSVNFHRI;GKPSGLRPGRKSTT;LSVGLGTCVYLWSACTSQ;STTSRRCAWTLPS;VSPYSLSPVSN 5 12.6 1.0012 -0.94765 8.5254 0 0 0 0 0 8.36877 9.98228 12.3857 0 0 0 0 0 0 A0A8I3NCD1 A0A8I3NCD1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] SPQPQGSSLLMLRA 1 6.3 0.93499 0.093335 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.28003 A0A8I3NCE1 A0A8I3NCE1_CANLF Cadherin 16 CDH16 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EAGHVLWGAQPVLV;FYILNQAPAWP;GALALSPEGSTSL;LVNDSEGWLCIKEVSGEVHTA 4 7.9 0.9951 -0.084278 0 0 10.3534 0 0 5.54652 0 0 0 8.96203 0 0 0 0 6.72342 A0A8I3NCF1 A0A8I3NCF1_CANLF Four and a half LIM domains 2 FHL2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634]; Z disc [GO:0030018] transcription coregulator activity [GO:0003712] YASTCEECGKPIGCDCKVPARWS 1 15.2 0.97987 0.04626 0 0 0 0 4.82589 0 0 0 0 0 0 0 0 0 0 A0A8I3NCF2 A0A8I3NCF2_CANLF Transmembrane protein 138 TMEM138 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; vacuolar membrane [GO:0005774] PVIQLVLFIIQ 1 10.7 0.98183 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 5.26044 0 A0A8I3NCF4 A0A8I3NCF4_CANLF Structural maintenance of chromosomes 1B SMC1B Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; sister chromatid cohesion [GO:0007062] cohesin complex [GO:0008278]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ESLSRHENTVKAKKKE;IKNLRDRRAQLIQELKD;KQLAAFYREQSQLQSELLNIESQCT;LDDIIEVELGTE;WRSFEKQVEE 5 7.1 1.0017 -0.96337 11.4686 11.3533 0 0 5.64056 0 0 10.26 0 0 0 6.2083 0 9.71651 0 A0A8I3NCG5 A0A8I3NCG5_CANLF Phosphodiesterase (EC 3.1.4.-) PDE8B Canis lupus familiaris (Dog) (Canis familiaris) behavioral fear response [GO:0001662]; cAMP catabolic process [GO:0006198]; negative regulation of steroid hormone biosynthetic process [GO:0090032]; neuromuscular process controlling balance [GO:0050885]; operant conditioning [GO:0035106]; signal transduction [GO:0007165]; visual learning [GO:0008542] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]" AEIEGSDCECNPTG;DNYKHWKTLDDLKC;EIEGSDCEC;GGGGGGGA;GGGGGGGG;LVQTDAADAAP;NSPVTVAEALDRVLEILRTT;PGGGGGGG 8 8.8 1.0021 -0.74113 0 8.42689 0 0 8.81221 0 0 7.28512 0 10.6078 0 0 0 0 10.7205 A0A8I3NCG7 A0A8I3NCG7_CANLF Groucho/TLE N-terminal Q-rich domain-containing protein TLE2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] transcription corepressor activity [GO:0003714] AQIIPFLTQEH;PQDASTPGPSSASHL 2 4.2 0.99265 -0.2715 0 0 0 0 0 0 0 0 0 0 0 0 0 6.83162 0 A0A8I3NCH3 A0A8I3NCH3_CANLF PDZ and LIM domain protein 7 DBN1 Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779]; metal ion binding [GO:0046872] GSHLDSHRRMAP;LVPDASKQRLMEDTEDWRPR;MAPTPIPTRSPSDSSMASTP;QEERERRYREREQQI;TPVCHHCH;VIVNASSVE 6 7.7 1.0023 -0.9893 0 0 0 0 0 10.3205 8.4709 9.53803 0 0 0 0 12.6275 0 0 A0A8I3NCH4 A0A8I3NCH4_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SLPTELQN 1 3.6 1.0039 -1.1044 0 0 0 0 0 0 10.3897 0 0 0 0 0 0 0 0 A0A8I3NCH8 A0A8I3NCH8_CANLF Plexin B2 PLXNB2 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; excitatory synapse assembly [GO:1904861]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; positive regulation of translation [GO:0045727]; regulation of cell shape [GO:0008360]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932] plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] EESGHWLWSR;ELDLQCRDPS;FFVFNQQDKHPPRN;FLPSKDGDKDVMI;LILPLVIVPMVVVIAVS;LKFEEPVSAQEPG;LNHLVVDEASG;RTEAGAFEYVADP;RTEAGAFEYVADPTFENFTGG;RTEGREAF;SGAYRREVGGGGQMMG;VDVNGKLGHSPPHVQFT;VGSDLLKFEEPVSA;VLGELPLEIYYGGSRVPSP;YDCREAMSLAEN 15 9.8 0.95792 0.049233 0 0 0 0 0 0 9.68426 0 0 0 0 0 0 0 0 A0A8I3NCI7 A0A8I3NCI7_CANLF UV radiation resistance associated UVRAG Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] NELRKQTECL 1 1.6 0.98521 -0.24528 0 0 10.2328 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NCJ8 A0A8I3NCJ8_CANLF Kinesin family member 27 KIF27 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] microtubule motor activity [GO:0003777] IKVILSYFPAKHN 1 3.9 0.99033 -0.27395 0 0 0 0 0 0 12.9079 0 13.1027 0 0 0 0 0 0 A0A8I3NCK7 A0A8I3NCK7_CANLF RB associated KRAB zinc finger Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" APLGDKPY;HLEEKPYECNECGKTFN;LTVHRRSHLEE;NECGKTFNLNSAFIRHRKVHTDEKP;VILKLEQGEEPWVA 5 9.8 0.97336 0.038291 0 5.74074 0 0 0 0 5.09428 0 5.72846 0 8.95649 0 0 0 8.99602 A0A8I3NCK8 A0A8I3NCK8_CANLF Protein kinase D1 PRKD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] ALAPGGAVLSRLGH;APAGGVSF;DPDPDPEDSNRTISP;GGAEGRRGGDPAPCGY;GLQCKDCR;GPGRDPRAEGRRG;ISHEAIDLINNLL;QYAGEQGLRYP;WMVHYTSKDT 9 8.7 1.004 -1.1005 8.03172 0 15.0585 0 0 0 11.3927 9.22968 0 0 4.29697 9.70333 0 12.8964 5.92766 A0A8I3NCL6 A0A8I3NCL6_CANLF G-protein coupled receptor family C group 6 member A GPRC6A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] LAILLLALSLLGIILVLAIGII;PENHYSNQTDMDHCLLCNNETHWA;VICTIWLIFAA 3 6.7 0.99236 -0.17075 7.02148 0 0 0 0 0 0 11.0991 10.9669 0 0 4.31513 0 0 0 A0A8I3NCL8 A0A8I3NCL8_CANLF Scavenger receptor class A member 5 SCARA5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FILAGPPG 1 3 1.0042 -1.1044 0 6.05329 0 8.09587 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NCN0 A0A8I3NCN0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] IVDTQGSKNQPQ;QPEKKKLT 2 5.3 1.0025 -1.3555 0 0 0 0 9.97656 0 0 0 0 7.73545 0 0 0 0 0 A0A8I3NCN9 A0A8I3NCN9_CANLF Guided entry of tail-anchored proteins factor 4 GET4 Canis lupus familiaris (Dog) (Canis familiaris) protein insertion into ER membrane [GO:0045048] BAT3 complex [GO:0071818] EQNYCESRYHFLHSADGEGCAH;EVEVADELL;GVGVNKAG;PMYNEYLDRIGQLF;QQNSAADLSMLVLES 5 20 0.98953 -0.26527 0 0 0 0 0 14.5439 0 0 0 0 0 0 0 0 0 A0A8I3NCQ4 A0A8I3NCQ4_CANLF AHNAK nucleoprotein AHNAK Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane protein complex [GO:0098797]; sarcolemma [GO:0042383] S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493] APKISMPDFDL;DLHLKAPK;DVNIEEAEGKLKGP;DVNLPKADIDISGP;DVSLPKFEGDL;EAPDVSLEGPEGKL;EINIKAPKI;EVDENLPK;EVQAPDAGIHGS;FGISATQASIPDVNVS;GAVEVQDPS;GVFVQEVMQNSPAART;IDVSGPKVDIDVPDVN;LDVSAPKIE;NISMPDVDLNLKGP;PKFSVPGFKG;SLPNVEGDLKG;VDVTLPTGAVTL;YFDNLQSGEVT 19 7.4 1.0005 -2.7744 8.6067 10.5793 11.9716 0 0 8.48808 12.3433 13.1444 0 5.75804 10.9651 5.12858 10.1013 0 12.0737 A0A8I3NCR7 A0A8I3NCR7_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) CMTR1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] QCIICSEYFIEQRDCHEDHAPGTF;VTEEDWERMYPCLAP;YPCLAPKNDQ 3 9.6 0.99211 -0.29121 0 0 0 0 0 0 0 0 0 0 0 0 7.42417 0 0 A0A8I3NCS1 A0A8I3NCS1_CANLF "Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)" ACSF2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] catalytic activity [GO:0003824]; nucleotide binding [GO:0000166] KIPRYIVFVTDYPLTVSGKIQK;RGSFLYGTPTM 2 5.8 0.97493 0.046925 0 0 0 0 0 0 0 4.51627 0 0 0 0 0 0 0 A0A8I3NCS9 A0A8I3NCS9_CANLF Guided entry of tail-anchored proteins factor 4 GET4 Canis lupus familiaris (Dog) (Canis familiaris) protein insertion into ER membrane [GO:0045048] BAT3 complex [GO:0071818] EQNYCESRYHFLHSADGEGCAH;EVEVADELL;PMYNEYLDRIGQLF;QARLGTDSIPAS;QQNSAADLSMLVLES 5 19.7 1.0028 -1.1585 11.7208 10.8553 0 0 0 0 0 0 6.18452 0 9.58412 0 7.8732 0 0 A0A8I3NCT4 A0A8I3NCT4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RCFWIWVE 1 7.3 0.98419 -0.23825 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0684 0 A0A8I3NCU3 A0A8I3NCU3_CANLF Pleckstrin homology domain containing J1 PLEKHJ1 Canis lupus familiaris (Dog) (Canis familiaris) LKRRLVKLVVNFLFYFRT;RGPKKGSVLKRRLVKLVV;YFRTDEAEPVGALLLE 3 40.4 0.87044 0.13726 0 9.32028 0 0 0 5.19006 0 0 0 0 0 0 0 12.5216 0 A0A8I3NCV2 A0A8I3NCV2_CANLF Meiotic kinetochore factor MEIKIN Canis lupus familiaris (Dog) (Canis familiaris) "meiotic sister chromatid cohesion, centromeric [GO:0051754]" kinetochore [GO:0000776] IVKKKKYSPPKDIPQDII 1 5.4 0.97463 0.048313 0 0 0 0 0 0 0 0 8.38625 0 0 0 0 0 0 A0A8I3NCW7 A0A8I3NCW7_CANLF Protein kinase cAMP-dependent type I regulatory subunit beta PRKAR1B Canis lupus familiaris (Dog) (Canis familiaris) learning or memory [GO:0007611]; modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle cycle [GO:0098693] cAMP-dependent protein kinase complex [GO:0005952]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685] cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236] MVGAEGEGDRPGAGGGGV;QVEEDESLKECELYVQKH 2 8.1 0.99173 -0.0017295 0 0 0 0 0 0 0 0 0 0 0 0 0 8.34123 0 A0A8I3NCX3 A0A8I3NCX3_CANLF Prothymosin alpha Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAEDDEDDDVDP;EEEDGDGDEEAEAAAG;EEEEEEEGDGEEEDGDGDEEAE;GKEEEEEEEGDGEEED;NEENGEQEADNEVDEEEEEG 5 35.7 0.99375 -0.063144 0 0 0 0 4.80416 0 0 7.87897 10.7698 0 0 0 5.9875 0 0 A0A8I3NCY3 A0A8I3NCY3_CANLF CUGBP Elav-like family member 5 CELF5 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] PALETVYAN;RAEEGGGRRARGRGGREAGGGV;RLTESEARRQQ 3 7.5 1.0028 -0.72182 0 0 0 4.63169 0 0 0 0 0 0 0 9.12474 0 11.8468 0 A0A8I3ND01 A0A8I3ND01_CANLF Epoxide hydrolase 2 EPHX2 Canis lupus familiaris (Dog) (Canis familiaris) epoxide hydrolase activity [GO:0004301] EVVFLDDI;GVAEAELEQ;LAQLVCQLSPHFNFVIESCRISM;SIVTEEDIQF;WTQMEKPTE 5 11.3 1.0019 -1.3059 0 0 0 0 0 0 0 0 0 0 0 0 0 8.1919 8.5567 A0A8I3ND04 A0A8I3ND04_CANLF ADAM metallopeptidase domain 18 ADAM18 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] DPDIPLLAENY;ECDCGSQEECQFKKC;EECDCGSQEECQF;EPNEECDCGSQEECQ;GAQMICNNLGNCHCF;HSESSYFKMHCHYQGYVA 6 7.8 0.95054 0.053889 0 0 0 0 0 8.63681 0 0 0 0 0 0 0 0 0 A0A8I3ND05 A0A8I3ND05_CANLF NBR1 autophagy cargo receptor NBR1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AGKKPLAH;ASTEKKDVLVPC;EEEEEDELKDEVQSQ;GIEAGERLAEGEN;PPAVPEKRPVLRAGKKP;SEGAGFKV;WRMKNTGNVKW 7 9.6 1.0019 -1.7998 0 0 8.64147 5.52001 0 4.67689 0 0 0 10.0076 8.76182 0 0 0 0 A0A8I3ND07 A0A8I3ND07_CANLF Sodium/hydrogen exchanger SLC9A4 Canis lupus familiaris (Dog) (Canis familiaris) gastric acid secretion [GO:0001696]; glandular epithelial cell development [GO:0002068]; regulation of pH [GO:0006885]; transepithelial ammonium transport [GO:0070634] apical plasma membrane [GO:0016324] sodium:proton antiporter activity [GO:0015385] VEENVSQTSYTT 1 1.5 0.95235 0.05044 0 0 0 7.48018 0 0 0 0 0 0 0 0 0 0 0 A0A8I3ND16 A0A8I3ND16_CANLF G-patch domain containing 3 GPATCH3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; nucleoplasm [GO:0005654] nucleic acid binding [GO:0003676] EQTADDWDVDMSVYYDTDG;QPPTSMKF 2 5.2 1.0039 -1.055 0 8.7363 0 0 0 0 0 8.76676 9.45407 0 0 0 0 0 0 A0A8I3ND17 A0A8I3ND17_CANLF Glucose-6-phosphatase (EC 3.1.3.9) G6PC3 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; glucose-6-phosphate transport [GO:0015760] endoplasmic reticulum membrane [GO:0005789] glucose-6-phosphatase activity [GO:0004346] SIRLASKWCERPEWVH 1 4.6 0.96253 0.049233 0 0 0 0 0 0 0 0 7.50898 0 0 0 0 0 0 A0A8I3ND46 A0A8I3ND46_CANLF Speckle targeted PIP5K1A-regulated poly(A) polymerase (EC 2.7.7.19) (EC 2.7.7.52) (RNA-binding motif protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) EEF1G Canis lupus familiaris (Dog) (Canis familiaris) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; U6 snRNA 3'-end processing [GO:0034477]" cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] enzyme binding [GO:0019899]; enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA uridylyltransferase activity [GO:0050265]; U6 snRNA binding [GO:0017070] LGEGNLGKALEL;LTQKAGEGEQ;RLQNCCRAAANYCRSLQFQR;SLCSELDERVRPLV;SLDSALASPL 5 7.6 1.0029 -0.73705 0 0 10.8165 0 9.44706 0 0 0 9.71332 7.46695 0 0 0 0 0 A0A8I3ND50 A0A8I3ND50_CANLF Neurexophilin NXPH4 Canis lupus familiaris (Dog) (Canis familiaris) VSFLSFDYK 1 3 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 9.61504 0 0 A0A8I3ND53 A0A8I3ND53_CANLF Forkhead box H1 FOXH1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule biosynthetic process [GO:0010556]; regulation of primary metabolic process [GO:0080090] nucleus [GO:0005634] LPQAEAGPDHPSG 1 3.7 0.94437 0.059664 0 0 0 0 0 8.99577 0 0 0 0 0 0 0 0 0 A0A8I3ND60 A0A8I3ND60_CANLF UBX domain-containing protein 4 (UBX domain-containing protein 2) UBXN4 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635] DFKKEGKIYRLRTQDDG;VGNTYGNFSLATM 2 5.9 0.99218 -0.18409 0 0 0 0 0 0 0 0 0 0 0 0 11.729 0 11.3231 A0A8I3ND64 A0A8I3ND64_CANLF Serine and arginine rich splicing factor 11 SRSF11 Canis lupus familiaris (Dog) (Canis familiaris) commitment complex [GO:0000243]; nuclear speck [GO:0016607]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701] poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628] SAGVIPDETKA 1 2.6 0.98349 0.035491 0 0 0 0 0 0 5.38988 0 0 0 0 0 0 0 0 A0A8I3ND68 A0A8I3ND68_CANLF hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29) EGLN3 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cellular response to hypoxia [GO:0071456]; regulation of cell population proliferation [GO:0042127] cytosol [GO:0005829]; nucleus [GO:0005634] ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545] RHLRGDQITWI 1 4.6 0.98394 -0.24209 0 0 0 0 0 0 0 0 0 0 0 11.6135 12.8916 12.659 0 A0A8I3ND72 A0A8I3ND72_CANLF Anion exchange protein SLC4A2 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;FFLRKFKNSRFFPGRK;GEKTQDLIGVSELIMS;GETPTIEEGEEDEEEASEAEG;HPSDEKDFSFP;HSWMLMRRSQ;PGASPTGETPTI;PGFPEQEDDEL;PPPPTPPP;SDPHVTEPLIGGVPETR;SEAEGTRALSQ;SSVQFFLQ;SSVQFFLQE;TAPEKRGWVINPL;VEVAGAVEDDPLRR;VGLSIVIGDLLRQIPLAV;VGLSIVIGDLLRQIPLAVLFGIFLY;VKKVRTLR;YGEEDFEYH 19 16.3 1.0036 -1.6526 13.5785 0 10.6474 10.8225 9.77037 0 9.60153 6.13984 8.62735 11.829 0 3.40654 10.3217 8.26421 0 A0A8I3ND84 A0A8I3ND84_CANLF Prostate and testis expressed 1 PATE1 Canis lupus familiaris (Dog) (Canis familiaris) LTSLPDFLAP 1 8 0.99065 -0.26186 0 0 0 0 0 0 0 0 0 0 0 0 0 12.6707 0 A0A8I3ND90 A0A8I3ND90_CANLF GRAM domain containing 4 GRAMD4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] ERPLAVCENGWRCCLINRDRKM;GAPCWSSHCCCSG;GRFHGTKKGN 3 7.8 1.0044 -0.81705 0 0 0 0 10.4762 0 0 11.3723 0 0 6.01634 0 0 0 0 A0A8I3ND97 A0A8I3ND97_CANLF hyaluronan synthase (EC 2.4.1.212) HAS3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix assembly [GO:0085029]; extracellular polysaccharide biosynthetic process [GO:0045226]; hyaluronan biosynthetic process [GO:0030213]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hyaluranon cable assembly [GO:1900106] Golgi apparatus [GO:0005794]; hyaluranon cable [GO:0036117]; nucleus [GO:0005634]; plasma membrane [GO:0005886] hyaluronan synthase activity [GO:0050501]; identical protein binding [GO:0042802] EVLGGTEQ;FYRGRIWNILLFLLTVQLVGIIKAT;RSNFHEAGEGET 3 8.1 0.98859 -0.52335 0 0 0 0 0 0 6.40431 8.43158 0 0 0 0 0 0 0 A0A8I3NDA0 A0A8I3NDA0_CANLF Homeobox protein Hox-A2 HOXA2 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; brain segmentation [GO:0035284]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; middle ear morphogenesis [GO:0042474]; motor neuron axon guidance [GO:0008045]; muscle structure development [GO:0061061]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast development [GO:0002076]; pharyngeal system development [GO:0060037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rhombomere 2 development [GO:0021568]; rhombomere 3 morphogenesis [GO:0021658]; segment specification [GO:0007379] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KAAKKTAL;NDSPETLEVPSLQ;SQPSLAECLTSFPP 3 9.4 0.99196 -0.28744 13.2577 10.2295 9.12676 0 10.0987 10.0355 11.6549 0 0 13.8097 0 0 0 0 0 A0A8I3NDA3 A0A8I3NDA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KLLRAMRKRKISQL 1 10.8 0.93853 0.060769 0 0 4.18349 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDB8 A0A8I3NDB8_CANLF polynucleotide adenylyltransferase (EC 2.7.7.19) PAPOLG Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] cytosol [GO:0005829]; nuclear body [GO:0016604] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] VLNFFFFFF;YHLMPIITP 2 2.2 0.98617 -0.23652 0 0 0 0 0 0 10.0445 0 0 0 0 0 0 0 0 A0A8I3NDC3 A0A8I3NDC3_CANLF RNA exonuclease 4 REXO4 Canis lupus familiaris (Dog) (Canis familiaris) DNA catabolic process [GO:0006308]; DNA repair [GO:0006281]; rRNA processing [GO:0006364] nuclear speck [GO:0016607]; nucleolus [GO:0005730] 3'-5' exonuclease activity [GO:0008408]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; single-stranded DNA binding [GO:0003697] LGLKLPRKKSRKKRLWK;LPRKKSRKKRLWKSKRRA;NWRALQELLKQKTQAPEK 3 9.3 0.98965 -0.19652 0 0 0 5.29697 0 0 0 0 0 0 0 0 0 0 5.00693 A0A8I3NDD3 A0A8I3NDD3_CANLF ETS variant transcription factor 7 ETV7 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HARAPGSQRQAVLGGREPD;SIQMRRHTGVTRSWSV 2 7.9 0.99073 -0.51542 0 0 0 0 9.99308 0 0 0 0 0 0 0 0 0 0 A0A8I3NDD8 A0A8I3NDD8_CANLF tRNA isopentenyltransferase 1 TRIT1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] mitochondrion [GO:0005739] ATP binding [GO:0005524]; tRNA dimethylallyltransferase activity [GO:0052381] LIHIEDIFARDK 1 3.6 0.94209 0.05044 0 0 0 0 0 0 0 6.88423 0 0 0 0 0 0 0 A0A8I3NDD9 A0A8I3NDD9_CANLF Protein FAM221A FAM221A Canis lupus familiaris (Dog) (Canis familiaris) FTPEEYEEYKKKVLPM;HKTDFETILQQR;KRPEEDDMAF;VGQDVPYA 4 17.6 1.0024 -0.77067 0 9.10121 8.06064 0 5.17273 0 0 0 9.10337 0 0 0 0 8.70667 0 A0A8I3NDE3 A0A8I3NDE3_CANLF "Methyltransferase 13, eEF1A lysine and N-terminal methyltransferase" METTL13 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] VGLGGGSL;VHIADGLDYITSLAGR;VLVIGCGNSELSEQ 3 5.8 1.0023 -1.1686 11.8405 12.0807 0 9.74767 0 0 11.1431 10.989 0 0 0 0 0 0 9.74572 A0A8I3NDE4 A0A8I3NDE4_CANLF G2/M-phase specific E3 ubiquitin protein ligase G2E3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] AVEDGKSAITMEDL;LQAVEDGK;YPEAFYSIFCHKPEN 3 4.4 1.0038 -1.0434 0 0 8.95487 4.2368 7.09729 0 0 0 0 8.53792 8.40935 8.32486 0 8.7184 0 A0A8I3NDE7 A0A8I3NDE7_CANLF PDZ binding kinase PBK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DLIEERNKDSQ;LPDDDDDD 2 5.9 1.0038 -1.0689 0 0 9.07419 0 0 0 0 0 5.3718 0 0 0 0 0 0 A0A8I3NDF1 A0A8I3NDF1_CANLF "Polycystin 1 like 1, transient receptor potential channel interacting" PKD1L1 Canis lupus familiaris (Dog) (Canis familiaris) calcium channel complex [GO:0034704]; non-motile cilium [GO:0097730] calcium channel activity [GO:0005262] ALPEDPPPEVGGPDGAPVT;DLSLAASWSQRVMWLQ;GEEGGLDNG;LPGRRAQAVPS;PSRVNACQSRSPL;TDIDITFLA;WNEELSLRAECDACAAGP 7 3.8 0.98323 -0.24809 0 11.5879 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDF2 A0A8I3NDF2_CANLF Ribosomal RNA-processing protein 42 EXOSC7 Canis lupus familiaris (Dog) (Canis familiaris) RNA catabolic process [GO:0006401]; RNA processing [GO:0006396] cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730] DIELSDDPYDCFRLS;GVVTCMRKVGKGSLDPE 2 11 0.93745 0.10011 0 0 8.58143 0 7.32652 0 0 0 0 0 0 0 0 0 0 A0A8I3NDF7 A0A8I3NDF7_CANLF Homeobox protein Hox-A7 HOXA7 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell differentiation [GO:0048863] nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AADKADEEDEDDDDDDEEEE;DDDDDEEE;DEDDDDDD;EDEDDDDDD;IPGLCSDLAKGACDKA 5 15.6 0.98841 -0.22601 0 0 0 0 4.97357 0 0 0 0 0 0 0 0 0 0 A0A8I3NDG2 A0A8I3NDG2_CANLF Integrator complex subunit 15 INTS15 Canis lupus familiaris (Dog) (Canis familiaris) integrator complex [GO:0032039] DIYFSSQLQS;QVHLTEKNL;RLILITFLNTPIA 3 7.1 0.9992 -0.61146 0 0 0 0 0 0 0 0 0 9.58438 0 0 0 0 0 A0A8I3NDH0 A0A8I3NDH0_CANLF Zinc finger protein 354B ZNF354B Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEWRKLGPSQ;PWKVEKESPGGPSLGCKRSPKTT 2 5.4 0.97445 0.046623 0 0 0 0 9.0638 0 0 0 0 0 0 0 0 0 0 A0A8I3NDH2 A0A8I3NDH2_CANLF Homeobox protein Hox-B7 HOXB7 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; myeloid cell differentiation [GO:0030099]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190] cytosol [GO:0005829]; nuclear body [GO:0016604] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SSFNMHCAPFEQNLSGVCP 1 8.8 0.95348 0.049843 9.20271 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDH4 A0A8I3NDH4_CANLF Peroxisome proliferator-activated receptor alpha (Nuclear receptor subfamily 1 group C member 1) PPARA Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; fatty acid metabolic process [GO:0006631]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of inflammatory response [GO:0050728]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" HVLKLHLQTNHP;PDNIFLFPKLLQKMA;RGARGAGRGVGRGG;RVSHCRSSRVTVTFLFQGGGELG 4 7.4 0.99062 -0.21324 0 0 10.5426 0 0 0 0 0 0 0 0 0 0 0 9.81737 A0A8I3NDH8 A0A8I3NDH8_CANLF DNA polymerase kappa POLK Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EEEDNPQTLQ;LEQKTSDLTLFNVHVDVC;NQRIENMMQQKAQI 3 6.3 1.0043 -0.81811 6.68622 0 9.98114 0 0 11.1767 0 0 0 0 0 0 10.5745 9.84568 0 A0A8I3NDI8 A0A8I3NDI8_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN21 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein tyrosine phosphatase activity [GO:0004725] EPYTSSQDNLFATNQNG;ERMDGYGEESYPA;VGAVSVPELTNVQLQAQDYPAPN 3 4.8 0.99326 -0.16197 0 0 0 0 0 0 0 10.3399 10.7982 0 8.29218 0 0 0 0 A0A8I3NDK3 A0A8I3NDK3_CANLF RNA 3'-terminal phosphate cyclase (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) RTCA Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] nucleotide binding [GO:0000166]; RNA-3'-phosphate cyclase activity [GO:0003963] RGTRSRDSRISPGP 1 2.3 0.99636 -0.091109 0 0 0 0 9.35171 0 0 0 0 0 0 0 0 0 0 A0A8I3NDL2 A0A8I3NDL2_CANLF Protein shisa-5 (Scotin) SHISA5 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nuclear envelope [GO:0005635] CCGNCYYQYC;CCGNCYYQYCCSD;CCGNCYYQYCCSDE;CGNCYYQYCCSDE;ESCPEFCCGNCYYQYCCSDEL;FCCGNCYYQYCCSDE;LLLLLLLL;LLLLLLLLP;LLLLLLLP 9 12.6 0.99364 -0.044461 0 0 0 5.78571 0 0 0 7.36746 6.95292 0 0 0 0 4.95615 0 A0A8I3NDL3 A0A8I3NDL3_CANLF Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) CAPN2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] ISAFELQTILRRVLAK;LREVLNRFKLPPGEYIL 2 4.7 0.99155 -0.209 0 0 0 0 0 0 5.53863 0 0 0 0 0 0 0 10.0847 A0A8I3NDN0 A0A8I3NDN0_CANLF Cystic fibrosis transmembrane conductance regulator (EC 5.6.1.6) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (cAMP-dependent chloride channel) CFTR Canis lupus familiaris (Dog) (Canis familiaris) bicarbonate transport [GO:0015701] apical plasma membrane [GO:0016324]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; recycling endosome membrane [GO:0055038] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chloride channel activity [GO:0005254]; isomerase activity [GO:0016853] ETSLLMMIM;GVSYDEYRYRSV;IDGGNAILENIS;LDPYGQWNDQE;NSIRKFSIVQKTPLPM;SELQSLRPDFSS;TLQWAVNSSIEVDSLM;TWYDSLGAINKIQ;VLSHGHKQ;YDSFDQFSPER 10 8.4 1.0029 -1.5351 7.63212 10.3864 0 0 6.48315 9.49406 9.74121 0 7.18368 9.81298 0 0 0 0 0 A0A8I3NDN7 A0A8I3NDN7_CANLF Sodium/hydrogen exchanger SLC9A2 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; protein localization [GO:0008104]; regulation of intracellular pH [GO:0051453] apical plasma membrane [GO:0016324] sodium:proton antiporter activity [GO:0015385] GFHLYHKLPTI;KKLEIKHAI;LAVFENIHVN;PPLLLLLL;PPLLLLLLL;VGKNHEWN 6 5.8 1.003 -1.7232 0 0 0 0 0 0 0 12.177 0 0 8.10774 0 9.40131 9.99972 0 A0A8I3NDP2 A0A8I3NDP2_CANLF Uncharacterized protein BCL2L11 Canis lupus familiaris (Dog) (Canis familiaris) GDEFNAYYPR 1 11.5 0.98999 -0.26579 0 0 0 11.1877 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDP3 A0A8I3NDP3_CANLF Junctional cadherin 5 associated JCAD Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of sprouting angiogenesis [GO:1903672] cell-cell junction [GO:0005911] MKKAVWEEEL;NGCDHGPA;TISLESWHQP;VCAGPRQQ;VGRTEFQKQDLG 5 3.5 1.0041 -1.1044 0 0 0 6.35641 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDP7 A0A8I3NDP7_CANLF Solute carrier family 5 member 2 SLC5A2 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] cytoskeleton [GO:0005856]; membrane [GO:0016020] metal ion binding [GO:0046872]; transmembrane transporter activity [GO:0022857] EVCKRVCGTE;FCCVSCGEPFGDEGFHEREG;LFAPRCQGCQGP;SGDKDHLYSTVCKPR 4 8.1 0.98636 -0.32201 0 0 0 0 0 7.8679 0 12.2144 0 0 0 11.4467 0 10.297 0 A0A8I3NDQ7 A0A8I3NDQ7_CANLF Uncharacterized protein EFCAB11 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] GILLEEFLSIV 1 7.6 0.98303 0.035491 0 0 6.4003 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDR1 A0A8I3NDR1_CANLF Magnesium dependent phosphatase 1 MDP1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatase activity [GO:0016791] HFERLQQKTGVGFSQMIFFDDEKRN 1 15.2 0.99127 -0.29762 8.15669 8.36427 0 0 0 0 0 0 8.56605 0 0 0 0 0 0 A0A8I3NDR6 A0A8I3NDR6_CANLF Cyclin dependent kinase like 3 CDKL3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DQNQEKQELKNSGL;IKIFYEKPEK;RHENLVNLIEVF 3 6.2 1.0031 -1.1175 0 0 0 0 8.90301 0 0 11.1553 0 0 0 0 0 0 7.53286 A0A8I3NDT6 A0A8I3NDT6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PQGSAGPQGSAGPQESAG;SLPFPLPS;SQGSTGPQESAGPQES 3 13.1 0.98791 -0.37422 0 0 0 0 12.3362 0 0 0 0 9.47153 0 0 0 0 11.9748 A0A8I3NDU3 A0A8I3NDU3_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) LOC119872525 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] VIQMVHDHWVHIL 1 22.8 0.98942 -0.21593 0 0 0 0 0 0 0 10.5424 0 0 0 0 0 0 0 A0A8I3NDU7 A0A8I3NDU7_CANLF Uncharacterized protein HJV Canis lupus familiaris (Dog) (Canis familiaris) LRCNADSPLYLRT 1 19.7 0.94131 0.059814 0 0 0 0 0 0 0 8.30003 0 0 0 0 0 0 0 A0A8I3NDV0 A0A8I3NDV0_CANLF PDZ and LIM domain protein 4 PDLIM4 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; early endosome membrane [GO:0031901]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome membrane [GO:0055038]; stress fiber [GO:0001725]; synapse [GO:0045202]; Z disc [GO:0030018] actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371] ECFMCSDC;HPECFMCSDCGLNLK 2 4.5 0.98993 -0.21204 0 0 8.9321 6.83365 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NDV3 A0A8I3NDV3_CANLF Semaphorin 4A SEMA4A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] PHFLTVTVLLALVL 1 2.2 0.93387 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 4.48324 0 A0A8I3NDV5 A0A8I3NDV5_CANLF LanC like glutathione S-transferase 2 LANCL2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179] FPAFELAPPQRDRK;LVHWCHGAP;VGGFDSLSFRIVQNFTKRIQTKI 3 11.1 0.94309 0.061136 0 0 0 0 0 0 0 0 0 0 0 0 0 8.03881 0 A0A8I3NDV6 A0A8I3NDV6_CANLF Uncharacterized protein ADAMTS15 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LKGTCVERHNLNKYRVD;NKYRVDGFWAKWEP;QITAFREDFYL;RDLVVKGS 4 4.6 0.98406 0.035491 0 0 0 0 0 0 0 0 0 0 0 8.03067 0 0 0 A0A8I3NDV9 A0A8I3NDV9_CANLF Kinesin-like protein KIF12 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] GSGGFRGV;SLLALGHCISLLLDPQRRQSH 2 4 1.0036 -1.0557 0 0 0 8.63049 0 0 0 0 0 8.94468 0 0 0 0 0 A0A8I3NDX1 A0A8I3NDX1_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP10 Canis lupus familiaris (Dog) (Canis familiaris) aorta morphogenesis [GO:0035909]; collagen fibril organization [GO:0030199]; extracellular matrix assembly [GO:0085029]; in utero embryonic development [GO:0001701]; wound healing [GO:0042060] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758] calcium ion binding [GO:0005509]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] DLNKDGEVPL;EVELVSREEGLPTGYLFV;GEKGYGTVIPPQASLVFHVLLID;LVSREEGLPTGYLFVWHEDPP 4 9.8 1.0023 -0.66068 0 0 0 0 8.21218 0 10.9052 0 0 11.6532 0 0 0 0 0 A0A8I3NDX9 A0A8I3NDX9_CANLF Pipecolic acid and sarcosine oxidase PIPOX Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491] DECYQIWAQLEHEAE;IELPLQTPQLRCRHPLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLF;LLLLLLLLLL;PLLLLLLLLL 7 12.2 0.92302 0.095176 0 0 0 0 0 0 7.40939 8.71387 0 0 0 0 0 0 0 A0A8I3NDY4 A0A8I3NDY4_CANLF Vitellogenin domain-containing protein LOC111096475 Canis lupus familiaris (Dog) (Canis familiaris) lipid transporter activity [GO:0005319] AVLASGRAAASLW;DAEIRINAYLALMRCP;ELILDDRDVYYIKGRSDL;ERTLLFSP;GSMGLHIL;KVARRRAERRA;LGANCTFQEPSDAD;LLFSPASFLPRF;LPSEAEMHLTHTHVASNLS;LYQNPEEDAEI;SLDGGIEARKGRD 11 4.1 1.0026 -1.184 0 10.7342 0 0 3.53742 6.44935 9.03235 12.0557 0 0 13.0596 10.8709 0 13.2493 12.4872 A0A8I3NDY9 A0A8I3NDY9_CANLF Tenascin C TNC Canis lupus familiaris (Dog) (Canis familiaris) AGWDGLRLNWTAADPAYEHFVIQVQ;CSDMSCPNDCHQH;DEGHTGEDCGQ;DTTSYDLRGLE;IVTEVTEETV;LDGQCVCDEGFTGEDC;LENLVSSLREQCTTGA;LKKVIRHKRE;NGMCVCDDGYTGE;QCVCDEGFTGEDCS;RGYRTPVLSAEASTEAE;SGLVTANVTDTEALAMWQ;TEALAMWQ;TVSWMAPSAQVE;VLSAEASTGETPNL 15 9.3 1.0031 -1.9343 0 0 8.80474 0 6.50227 10.4582 0 9.26245 12.5659 7.99435 3.39643 6.83162 0 11.0124 5.06949 A0A8I3NDZ0 A0A8I3NDZ0_CANLF AFG1 like ATPase AFG1L Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]; mitochondrial protein catabolic process [GO:0035694]" mitochondrial membrane [GO:0031966] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] FDELAQKQN;FYDFKVRVI 2 3.8 1.0034 -1.6084 0 0 7.95704 8.55516 0 8.56083 0 0 0 0 0 0 0 0 0 A0A8I3NDZ6 A0A8I3NDZ6_CANLF MSL complex subunit 1 MSL1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; MSL complex [GO:0072487] chromatin binding [GO:0003682] EQRILQRLQLRMYKKKGI;IERMERRMQ;KEETVAIPSWRDHSVEPLR;NPSDLLENLDDSVF;PAGCGGKG;QLDLIEQQQQQLQ;SPAGCGGKGRGLLLPAGAA 7 15.4 1.0032 -2.3214 10.8478 8.9712 0 9.72429 0 9.29002 4.1981 10.799 0 0 0 0 0 0 0 A0A8I3NE22 A0A8I3NE22_CANLF Heat shock transcription factor 1 HSF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DHLDAMDSNLDNLQ;GSYFSEGDDYTD;ITELAPSSPLASPGG;SPSGNSFH 4 9.3 1.0031 -1.5284 4.80162 0 8.25791 0 0 13.1374 0 0 0 10.4968 0 0 0 0 0 A0A8I3NE28 A0A8I3NE28_CANLF Cold-inducible RNA-binding protein (Glycine-rich RNA-binding protein CIRP) CIRBP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] ETQRSRGFGFVT 1 7.1 0.95294 0.05044 0 0 0 7.43137 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NE29 A0A8I3NE29_CANLF Riboflavin transporter SLC52A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] riboflavin transmembrane transporter activity [GO:0032217] VLVALGNLGLLLVTLWRRLAPGKSE 1 7.2 0.97617 0.035538 0 0 0 0 0 0 0 5.82807 0 0 0 0 0 0 0 A0A8I3NE36 A0A8I3NE36_CANLF tRNA:m(4)X modification enzyme TRM13 (EC 2.1.1.225) TRMT13 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050] ERLQIDIQHLCL;PISSLSEEQLESL;VGIGKHLCGVATGSLLLKKRR 3 15.9 0.97698 0.047166 0 0 0 0 0 3.6941 5.60377 0 0 0 0 0 0 0 0 A0A8I3NE38 A0A8I3NE38_CANLF Nerve growth factor receptor NGFR Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; cellular response to amyloid-beta [GO:1904646]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; detection of temperature stimulus [GO:0016048]; dorsal aorta development [GO:0035907]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fibroblast proliferation [GO:0048144]; hair follicle morphogenesis [GO:0031069]; intracellular glucose homeostasis [GO:0001678]; intracellular protein transport [GO:0006886]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of hair follicle development [GO:0051799]; nerve development [GO:0021675]; neuron apoptotic process [GO:0051402]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; positive regulation of protein localization to nucleus [GO:1900182]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; Rho protein signal transduction [GO:0007266] cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793] calmodulin binding [GO:0005516]; coreceptor activity [GO:0015026]; death receptor activity [GO:0005035]; nerve growth factor binding [GO:0048406]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625] AKEACPTGL;EGVAQPCGANQTVCEP;EPELPPDQEI;GSAGDTWRHLAGELGYQPEHIDSF;LLLLLLLL;LLLLLLLLL;PELPPDQEIIASTMADV;RLLLLLLL;RLLLLLLLL 9 17.9 1.0032 -1.5009 9.34212 0 0 8.95591 0 0 0 0 8.35248 0 0 0 5.25554 9.9485 0 A0A8I3NE41 A0A8I3NE41_CANLF Bisphosphoglycerate mutase PGAM2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] intramolecular phosphotransferase activity [GO:0016868] ISKERRYAGLKPGE;QENRFCGWFDAEL;WPGWGWGRPV 3 12.8 0.98796 -0.48729 0 0 8.38599 0 0 0 0 0 0 0 0 0 0 0 9.81479 A0A8I3NE50 A0A8I3NE50_CANLF Cytochrome b5 heme-binding domain-containing protein CYB5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] heme binding [GO:0020037]; metal ion binding [GO:0046872] TPATPGPPGGFPKSRY 1 5.1 0.99295 -0.17891 0 0 0 0 0 0 0 0 0 0 0 0 0 7.89972 0 A0A8I3NE51 A0A8I3NE51_CANLF Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Retinol isomerase) DEGS1 Canis lupus familiaris (Dog) (Canis familiaris) myelin maintenance [GO:0043217]; sphingolipid biosynthetic process [GO:0030148] endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739] retinol isomerase activity [GO:0050251]; sphingolipid delta-4 desaturase activity [GO:0042284] HSVTLAIHEVSHNSAF;IQVIFDITVYYVFGI;TTFRKFIWVVLQPLFYA 3 14.9 0.99291 -0.14896 0 0 0 0 0 0 5.67852 5.4707 0 0 0 0 0 0 11.1295 A0A8I3NE78 A0A8I3NE78_CANLF Mitochondrial ribosomal protein L12 MRPL12 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial transcription [GO:0006390]; positive regulation of DNA-templated transcription [GO:0045893]; translation [GO:0006412] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] QVPRVCAVRLMRCSSHRMGE 1 10.1 0.98171 -0.24879 0 0 0 0 0 0 0 0 0 0 0 0 0 8.90707 0 A0A8I3NE84 A0A8I3NE84_CANLF Adhesion G protein-coupled receptor G6 ADGRG6 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DSLSLDNGESQTKFCGATAKGL;EEAPNCIYDSL;ESNLSCDGIVYRISIVIQ;HWKWKPHSLLFLF;IDELAFKIDLNTTSRVNI;KDKEDIFTESFEQLC;TFTSPCYPNDY 7 8.8 0.97881 0.048313 0 0 0 0 0 8.1265 0 0 0 0 0 0 0 0 0 A0A8I3NE90 A0A8I3NE90_CANLF Dipeptidyl peptidase like 10 DPP10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein localization to plasma membrane [GO:1903078]; proteolysis [GO:0006508] voltage-gated potassium channel complex [GO:0008076] serine-type peptidase activity [GO:0008236]; transmembrane transporter binding [GO:0044325] AAVKFLLK;GVQGQQLIYIFEN;HTREVWELNPPEVE;IDSKRLSIFGKGYG;KTVKELGSNSPPQR;LIYIFENNIY;TMSVILLTPDELT 7 9.9 1.0017 -1.8191 0 0 0 0 0 0 0 8.54982 7.05723 0 9.91931 0 0 10.0356 5.14694 A0A8I3NE91 A0A8I3NE91_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK2 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; heart development [GO:0007507]; negative regulation of relaxation of smooth muscle [GO:1901081]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; receptor internalization [GO:0031623]; symbiont entry into host cell [GO:0046718]; tachykinin receptor signaling pathway [GO:0007217]; viral genome replication [GO:0019079] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793] ATP binding [GO:0005524]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein-coupled receptor kinase activity [GO:0004703] EDYALGKDCI;ELRDAYREAQQLVQRVP;FCQWKNVELNIHLT;HASVGTHGYMAPEVLQK 4 8.5 0.97855 0.046227 0 6.30106 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NE92 A0A8I3NE92_CANLF Zinc fingers and homeoboxes protein 1 ZHX1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]" EEDEEETDDSDTW;EVIDDQEEDEEETDDSDTWE;LVNKSHMGYEQVREWFAERQR;QEEDEEETDD;RDESGAPKPG;VECNFLTKRYDA;VIDDQEEDEEETDDSDT 7 7.2 1.0019 -1.3066 5.52099 0 0 6.77808 0 0 10.0982 10.8041 5.1458 0 0 0 0 5.24009 0 A0A8I3NE94 A0A8I3NE94_CANLF Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] HFILDECDK;PSEVQHECIPQ 2 4.7 1.0035 -0.80421 0 0 0 0 0 0 0 5.72689 0 0 0 0 0 0 0 A0A8I3NE97 A0A8I3NE97_CANLF Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1C adrenergic receptor) ADRA1A Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vasoconstriction [GO:0045907]; regulation of cardiac muscle contraction [GO:0055117] caveola [GO:0005901]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] alpha1-adrenergic receptor activity [GO:0004937] ASIMGLCIISIDRY;CWLPFFLVMPIGSFFPDFKPS;VFLSGNASDSSNCT;VISIGPLFGWRQ 4 14.4 0.93676 0.0628 0 0 6.69669 0 0 11.4405 9.09722 11.3198 10.295 0 9.77223 0 10.1481 0 0 A0A8I3NEA1 A0A8I3NEA1_CANLF Protein kinase D1 PRKD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] ALAPGGAVLSRLGH;APAGGVSF;AVGAVCRGAGAAVPGSPDH;DPDPDPEDSNRTISP;GGAEGRRGGDPAPCGY;GLQCKDCR;GPGRDPRAEGRRG;WMVHYTSKDT 8 8.5 0.95293 0.049818 0 0 0 0 0 0 0 0 5.68586 0 0 0 0 0 0 A0A8I3NEB5 A0A8I3NEB5_CANLF Sodium/bile acid cotransporter SLC10A7 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] symporter activity [GO:0015293] NEWLLKGLQTVGCMP;PLLIYHPV;VGGNEAAAIFNSAFGSFLLGSS;VGVNGGPL 4 16.2 1.0019 -1.2682 0 8.48026 0 7.13278 0 0 0 0 0 0 0 0 10.8612 10.4943 9.96216 A0A8I3NEB7 A0A8I3NEB7_CANLF Regulating synaptic membrane exocytosis 3 RIMS3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300] cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic membrane [GO:0042734] small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325] PHLSHSVPLEFHRTRVLEE 1 6.1 0.94977 0.049977 0 7.94087 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NEB9 A0A8I3NEB9_CANLF Protein inhibitor of activated STAT 3 RNF115 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] SUMO ligase activity [GO:0061665]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] PGPPPVGS;TIVVNWSSEFGRNYSL;YTVEEEVRQLPCNHF 3 4.8 0.98779 -0.46046 0 0 0 0 0 0 0 0 9.79812 0 7.2484 0 5.80012 0 0 A0A8I3NEC2 A0A8I3NEC2_CANLF THUMP domain containing 3 THUMPD3 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] cytosol [GO:0005829]; nucleolus [GO:0005730] RNA binding [GO:0003723]; tRNA (guanine(6)-N2)-methyltransferase activity [GO:0160117]; tRNA (guanine(7)-N2)-methyltransferase activity [GO:0160118] AAVYLLKRT;ACLREMSR;ATEWSNCY;EFKDYPFKETKEEVLKDFEEL;GKIYFDISVESLAQVHCLRSVDNLF;KKKKTKRKKI;KKKKTKRKKIN;NIGGLHAA;NSSKEKTNNGQ 9 19.7 0.99732 -3.7696 6.34275 0 2.47264 0 8.1537 0 0 11.1009 0 0 0 4.74642 7.59492 0 12.1304 A0A8I3NED0 A0A8I3NED0_CANLF IKAROS family zinc finger 1 IKZF1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AEGPPRSNHSAQDSAVENLLLLS;CNMCGYHSQDRYEFSSHITRG;FVGDKCLSDMPYDSSA 3 17.9 0.97513 0.047166 0 5.40609 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NED3 A0A8I3NED3_CANLF GPN-loop GTPase 2 GPN2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DLRLTAVHLVDSHYC 1 4.8 0.95056 0.053889 0 0 8.91286 0 0 0 0 0 0 0 0 0 0 9.53605 0 A0A8I3NED6 A0A8I3NED6_CANLF CD164 molecule like 2 CD164L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VVKEGCSIYNR 1 6.3 0.98437 -0.25342 0 0 0 0 0 0 0 0 0 0 0 0 12.0708 0 0 A0A8I3NED8 A0A8I3NED8_CANLF Centrosomal protein 57kDa-like protein 1 (Cep57-related protein) CEP57L1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] EQDHMKLQAKLEKLDVLEK;QVTQHYGPHTHQKLTEPRCL 2 8.8 0.98936 -0.20338 6.99141 0 0 0 0 8.52634 0 0 0 0 0 0 0 0 0 A0A8I3NEE4 A0A8I3NEE4_CANLF "GTPase, IMAP family member 2" GIMAP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; identical protein binding [GO:0042802] IFGEDVMRHTIVLFTH;LVTECESVWSRERLK 2 9.3 0.93766 0.10377 0 0 0 0 6.09569 0 0 0 0 0 0 0 0 0 7.28947 A0A8I3NEE9 A0A8I3NEE9_CANLF YTH domain-containing family protein YTHDF2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA destabilization [GO:0061157] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247] DVRWIFVKDVPNSQLRHI;FIIKSYSEDDIHRSI;STEHGNKRLDAAYR 3 8.1 0.98097 0.048313 0 0 0 0 0 0 0 0 9.79943 0 0 0 0 0 0 A0A8I3NEF4 A0A8I3NEF4_CANLF Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) PDGFA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] membrane [GO:0016020] growth factor activity [GO:0008083] AEEAEIPREVI;KSGPGPHPL;SLPSTQRLGS 3 7.5 1.003 -0.89403 0 0 0 0 0 9.82652 0 0 0 0 0 0 0 0 0 A0A8I3NEH2 A0A8I3NEH2_CANLF Solute carrier family 25 member 44 SLC25A44 Canis lupus familiaris (Dog) (Canis familiaris) branched-chain amino acid catabolic process [GO:0009083] membrane [GO:0016020]; mitochondrion [GO:0005739] branched-chain amino acid transmembrane transporter activity [GO:0015658] QTKDIIRQ;SILTNPMDV 2 5.4 1.0043 -1.0947 13.1479 0 8.58214 0 0 0 12.7988 0 0 0 0 0 0 0 0 A0A8I3NEH7 A0A8I3NEH7_CANLF Keratin-associated protein 9-3-like LOC102151404 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCSYCCQPTC;CCQPTSCQTSCCHCGTGC;CCSYCCQPTCCQPTCCGPTC;CRPSYCGQSCCRPA;CSTSGNCGSSCCQPSCCQTSCCQP;QPSCCQTSCCQPTSCQTSCCH;QPSCCQTSCCQPTSCQTSCCHCG;SGNCGSSCCQPSCCQTSCCQPT;SSCCQPSCCQTSCCQ;STSGNCGSSCCQPSCCQTSCCQPT;TSCQTSCC;TSGNCGSSCCQPSCC;YCCQPTCCQPTCCG 13 51.8 1.0018 -0.6705 5.00567 4.99336 0 5.84064 0 0 9.66126 3.69321 0 0 0 0 0 8.26969 6.2457 A0A8I3NEH9 A0A8I3NEH9_CANLF Nucleolar protein 3 HSF4 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel remodeling [GO:0001974]; cardiac muscle cell apoptotic process [GO:0010659]; intrinsic apoptotic signaling pathway [GO:0097193]; mRNA splice site recognition [GO:0006376]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein complex oligomerization [GO:0051259]; regulation of gene expression [GO:0010468]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to hypoxia [GO:0001666]; response to injury involved in regulation of muscle adaptation [GO:0014876]; response to ischemia [GO:0002931] mitochondrion [GO:0005739]; sarcoplasm [GO:0016528] calcium ion binding [GO:0005509]; caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802] AERRVRRLLLLV;PGAPGGSE 2 9.8 1.0042 -1.0539 0 0 0 0 0 4.7566 0 0 10.2102 0 0 0 0 0 0 A0A8I3NEI3 A0A8I3NEI3_CANLF Glycerophosphodiester phosphodiesterase domain containing 5 GDPD5 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] phosphoric diester hydrolase activity [GO:0008081] ATSLRRGHIQRLN;EYCLMWVTADLI;QNQSICSLAELLELAKG;VTISLDGVPFLMHD;WLFSLLWCAG 5 13.6 0.98696 -0.3597 0 0 0 0 9.03681 8.10376 0 0 0 0 9.33506 0 0 0 0 A0A8I3NEI5 A0A8I3NEI5_CANLF Ring finger protein 213 RNF213 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] CVCVCACACVCGCRGG;DLFLDGVSLRKT;EKHYLDINTVLE;GKPRITLMGIPTL;GLSKKLVEIF;GVVSVWSVDALAL;ICMETGKMVVLLNLQ;IFPVALFVEHVVLGVRSKI;KLHETICSITKDE;LALGDWHQ;LEELWVQAQYITGAE;LGDWHQYDDMVRM;LLREENMLSQMDRYL;LLTHLALL;LVSYMETKDSEIPPELEY;NLSRILTIYPQILQVL;PEDLLVQARNWKGLET;PYIMVHNDMSP;SDGCKALSVIEVTLGFLSTAGG;SLDAIHPSSGRVI;TYSMWCSPEP;VEYLQEMTRIRLCLNKAS;VIMDGVRDEDLAPFSLRK;VLDRDSNLE;VLHMALWSCINQLHTQRP;VLPAALAIYRHM;VMHTLCKCKEQAS;VPLKVIRLI;YSMWCSPEPASEA;YTAEQLVYLSTQLKEQKP 30 8 0.94928 0.049568 0 0 0 0 0 0 0 0 0 0 0 0 0 7.63662 0 A0A8I3NEI8 A0A8I3NEI8_CANLF Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) THRA Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinoic acid receptor signaling pathway [GO:0048384]; thyroid hormone receptor signaling pathway [GO:0002154] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CGEDDSSEAGSLSSSEEEPEEVC;GAAAEGRPGGSLGVHPEG;MPDGDKVDLEAF;NLDDTEVALLQAVLLMSTDR;QEVRQEEE 5 15.9 1.0027 -1.1964 0 0 0 10.2581 0 9.47186 0 0 0 0 0 5.04286 0 0 0 A0A8I3NEJ5 A0A8I3NEJ5_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) PPIL1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; protein folding [GO:0006457] catalytic step 2 spliceosome [GO:0071013] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] EVERRKPEV;LTPEVAVL 2 6.8 0.9867 -0.45799 0 0 9.93565 0 0 0 0 0 0 0 0 9.84687 0 0 10.8499 A0A8I3NEJ8 A0A8I3NEJ8_CANLF Interleukin 22 receptor subunit alpha 2 IL22RA2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of inflammatory response [GO:0050728]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509] cytosol [GO:0005829] interleukin-22 binding [GO:0042017]; interleukin-22 receptor activity [GO:0042018] SLEKEQKVYEGA 1 5.2 0.94121 0.05044 8.57228 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NEK1 A0A8I3NEK1_CANLF HIVEP zinc finger 2 HIVEP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] metal ion binding [GO:0046872] DDEDDDDFDDQGD;DDNDEDDEDDDDF;DDNDEDDEDDDDFDDQ;DGDDNDEDDEDDDD;DGEDGDDNDEDDEDDDDF;EDGDDNDEDDEDD;EDGDDNDEDDEDDDDFDDQ;EESDGEDGDDNDEDDEDDDDFDD;ESDGEDGDDNDEDDED;ESDGEDGDDNDEDDEDDDD;GEDGDDNDEDD;GEDGDDNDEDDEDDDDFD;NSMPTSSATNLSIPPSLRGSHS;PKTRSRSTS;QGDLTPKTRSRSTSPQ;QNSPAIVICKVDENTT;SDGEDGDDNDEDDEDDDD;SDGEDGDDNDEDDEDDDDFD;STDHQFSDAEESDGEDGDDNDEDD;TVPAGSYSLSVPGHHHQKE;VICKVDENTTQRTLVTNA;VLGPPNLRRG 22 5.1 1.0021 -1.2368 5.93878 8.52752 10.0925 6.88923 7.46459 8.32175 12.196 10.0143 10.885 0 7.40863 9.5478 7.5697 7.20614 11.8496 A0A8I3NEL4 A0A8I3NEL4_CANLF Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) AIMP2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]; type II pneumocyte differentiation [GO:0060510] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090] ADEPAAFST;KSPWLVGNELTVAD 2 7.2 0.99555 -0.56838 0 0 0 0 0 0 9.67943 0 0 0 0 0 0 0 0 A0A8I3NEM0 A0A8I3NEM0_CANLF Drebrin 1 DBN1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371] LVPDASKQRLMEDTEDWRPR;RGHGSRRWQQWQDSC 2 11.7 0.98974 -0.26403 0 0 0 0 0 0 0 0 0 9.6339 0 0 0 0 0 A0A8I3NEM3 A0A8I3NEM3_CANLF Laccase domain containing 1 LACC1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; transferase activity [GO:0016740] FNVEKFYRIKTDHA;VGPCCFTLP;YLTGFLYNCFL 3 8.5 0.98642 -0.3948 0 0 0 0 0 0 7.3443 0 0 0 0 0 0 0 8.34944 A0A8I3NEN5 A0A8I3NEN5_CANLF "RNA polymerase II, I and III subunit K" LOC119872826 Canis lupus familiaris (Dog) (Canis familiaris) "RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]" DNA binding [GO:0003677]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056]; zinc ion binding [GO:0008270] NEIKSRDPIRCR 1 20.7 0.99149 -0.27255 0 0 0 0 8.13679 0 0 0 0 0 0 0 0 0 0 A0A8I3NEP0 A0A8I3NEP0_CANLF Follicle-stimulating hormone receptor (Follitropin receptor) FSHR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled receptor activity [GO:0004930] ISLAEDEESSYAKGFDMMYS;LPSLEKFVA;SEFDYDLCNEVVD 3 6.2 1.001 -0.6222 0 0 0 11.017 0 0 0 0 0 8.67331 0 0 0 9.45078 9.15545 A0A8I3NEP2 A0A8I3NEP2_CANLF T-complex-associated-testis-expressed 1 TCTE1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126] CGMNFEWNLFLFTYQDC;EFDLRLSDVAQ;ENLIKHFIPSTTDP 3 8.4 0.87268 0.14281 0 0 4.11337 9.77604 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NER6 A0A8I3NER6_CANLF N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) GNS Canis lupus familiaris (Dog) (Canis familiaris) glycosaminoglycan metabolic process [GO:0030203] lysosome [GO:0005764] metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449] KMNYRLMMLQSCSGPTCR;LLLLLLLL;LLLLLLLLL;QTLLSVDDLVE 4 7.1 0.98543 -0.24123 0 0 7.83561 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NES1 A0A8I3NES1_CANLF Prostate and testis expressed 2 PATE2 Canis lupus familiaris (Dog) (Canis familiaris) ELKEHLTGRSMYFY;SNKGELKEHLTGRSMYF 2 25.7 0.9894 -0.19728 0 0 0 0 0 9.41026 0 0 0 0 9.33637 0 0 0 0 A0A8I3NET8 A0A8I3NET8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCGSCGGSQSC;CGGSQSCCCKPSSCCKPCCSQSSC;CGSCGGSQSCCCKPSSCCKP;CVPACPCSSCGSCGG;GGCGSCGGS;GGCGSCGGSKGCCGSCGGSQSCCCK;GGCGSSCC;GGSKGCCGSCGGSQSCCCK;GSCGSCGGSKGGCGSCGG;KGCCGSCG;PCCCESSCCKPCC;PCCCESSCCKPCCSQSCCC;PVCCCVPACPCSSCG;SCCKPCCCESSCCKPCCSQSCCC;SQSSCCKPCCCESSCCKPCCSQ;SSCCKPCCCESSCC;SSCCKPCCSQSCCCKPCCSQSSCC 17 79.8 1.0025 -1.165 9.28626 0 0 0 0 0 6.88032 8.47901 8.2897 0 0 5.49962 0 7.29572 4.14437 A0A8I3NEU0 A0A8I3NEU0_CANLF Peptidase S1 domain-containing protein LOC100684662 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] EFRETWVQVGIVSWGIGCGHKNSP;GRSLGLLLWLLLLPP;IRYERCNEILQ;QVSLQINEKHM;VEYTVKMGDI;VEYTVKMGDIYMR 6 19.7 0.99361 -0.28127 10.2583 0 0 0 0 0 0 8.0468 0 0 9.12655 5.09204 8.84493 0 0 A0A8I3NEU9 A0A8I3NEU9_CANLF Leucine rich repeat and fibronectin type III domain containing 4 LRFN4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synaptic membrane adhesion [GO:0099560] cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978] HRGLLFVPPNVDRR;LDHNLIDAL;PPLLLLLL;RHTQRLWVL;TLEIGVTGS 5 7.7 0.98632 -0.39222 0 0 11.1922 8.1442 0 0 0 0 0 0 4.178 3.2656 4.73064 3.6573 0 A0A8I3NEW4 A0A8I3NEW4_CANLF Solute carrier family 41 member SLC41A3 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion transport [GO:0015693] membrane [GO:0016020] inorganic cation transmembrane transporter activity [GO:0022890]; monoatomic cation transmembrane transporter activity [GO:0008324] GAGSATYP;IQHWPVFVE;LVCIGFMALIPMWV;VGQQWIGQNEACMETWE 4 8.7 1.0022 -1.2198 0 0 0 0 0 9.37339 0 0 9.72918 0 0 3.52695 0 0 0 A0A8I3NEY9 A0A8I3NEY9_CANLF Integrin subunit alpha D ITGAD Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] metal ion binding [GO:0046872] CSIADCMRFHCDFPSFGI;DGLVDLAVGARRQVLLLRTR;KYAIYTVISSHEQSTKYL;LELNMNVM;VWTNLEVFHPQNPSIQ 5 6.9 0.54054 0.43312 0 0 13.0941 0 0 0 0 8.08375 7.96075 0 0 0 0 8.64497 5.42213 A0A8I3NEZ3 A0A8I3NEZ3_CANLF NOP2/Sun RNA methyltransferase 6 NSUN6 Canis lupus familiaris (Dog) (Canis familiaris) RNA methylation [GO:0001510] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] HVLDPQPGE;VYLSPSFDNVLPRYLFL 2 6.1 1.0026 -0.75799 11.4083 0 0 0 0 8.58913 0 0 0 0 0 0 0 0 0 A0A8I3NEZ5 A0A8I3NEZ5_CANLF Solute carrier family 25 member 10 SLC25A10 Canis lupus familiaris (Dog) (Canis familiaris) glyceraldehyde-3-phosphate biosynthetic process [GO:0046166] mitochondrial inner membrane [GO:0005743]; nucleoplasm [GO:0005654] malate transmembrane transporter activity [GO:0015140]; secondary active transmembrane transporter activity [GO:0015291] LCRQMTYSLTRFAIYETVRDHVAKD;LSTGYLTDG 2 11.4 0.9896 -0.51722 0 0 0 0 0 12.2283 0 0 0 0 0 0 0 0 0 A0A8I3NEZ9 A0A8I3NEZ9_CANLF NTR domain-containing protein ADAMTSL5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] DLHPRSTCWPP;SAGCDGLLGSDAH;SEIFYTWK;SHVHRCPCTIHCREQ 4 7.1 0.98731 -0.36109 0 5.73844 0 0 0 10.31 0 0 8.94078 0 0 0 0 0 0 A0A8I3NF02 A0A8I3NF02_CANLF Carnitine palmitoyltransferase 1A CPT1A Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] membrane [GO:0016020] acyltransferase activity [GO:0016746] LLHGRCFDRWFDKS;PEYVSSGG;SMTRLFREGRTETV;TDTIQHIRDSKHIVVF;VLAMVDPTQT 5 8.4 1.0028 -0.86961 0 9.26857 0 0 0 0 0 0 12.7697 0 8.07221 8.34096 0 0 10.034 A0A8I3NF19 A0A8I3NF19_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RC3H2 Canis lupus familiaris (Dog) (Canis familiaris) P-body [GO:0000932] metal ion binding [GO:0046872]; transferase activity [GO:0016740] CYNEFDEN;DLDSGDVKRRVHLFETQRRTKEED;LVNCQLVEEEGRVRAMR;PSTNGISNAENNVSQLIPRS 4 6.1 0.9377 0.089961 0 0 0 0 0 8.95905 10.3852 0 0 0 0 0 0 0 0 A0A8I3NF20 A0A8I3NF20_CANLF GABA(C) receptor GABRR2 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; nervous system process [GO:0050877]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]; neurotransmitter receptor activity [GO:0030594] GVMLDGSYSDGEVNDLGNY;QPDGKVLYSLRVTV;TLASERSSPQ;VDIYLWVSFVFV 4 11.9 0.98739 -0.46771 9.02901 0 0 0 0 0 0 0 0 0 0 0 0 8.50569 0 A0A8I3NF21 A0A8I3NF21_CANLF Protein-tyrosine sulfotransferase (EC 2.8.2.20) TPST1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] protein-tyrosine sulfotransferase activity [GO:0008476] HIPWNHSVLHHEEMIGK;IKPVNVGALSKWV;TDEVLDSAMQAFLLEIIV 3 13 0.8589 0.15424 0 0 0 7.36755 0 0 0 7.05365 0 0 0 0 7.00101 0 0 A0A8I3NF23 A0A8I3NF23_CANLF Notchless protein homolog 1 NLE1 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] nucleolus [GO:0005730] LVRGQGPERLV;TGKYLASGSGD;VISVAFSPTGKYLASGSGDTTIL 3 7.7 0.97695 0.046343 0 0 0 0 0 0 8.53924 0 0 0 0 0 0 0 0 A0A8I3NF24 A0A8I3NF24_CANLF DNA-directed RNA polymerase III subunit POLR3GL Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase III [GO:0006383] RNA polymerase III complex [GO:0005666] EEEEEEYDEEEHEEETDYIMSY;EEEEEEYDEEEHEEETDYIMSYFDN;EEEVTSEEDEEKEEEEE;KEEEEEEEYDEEEHEEETDY;PRELKIRVRKLQKERTTIL;TSEEDEEKEEEEEKEEEEEEEYDEE 6 32.3 0.98647 -0.38781 0 0 7.67504 0 0 0 0 5.19235 5.93866 4.98682 0 0 6.61123 9.91827 0 A0A8I3NF29 A0A8I3NF29_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PDIK1L Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CDGGDMNE;GIIIWAMLE;QGTEIVPVGEALL;VGEALLENP 4 9.7 1.0033 -2.412 9.7106 9.05039 5.4871 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NF30 A0A8I3NF30_CANLF Olfactory receptor OR52L1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVLLLPFPILLQRLLF 1 5.1 0.95464 0.049233 0 0 0 0 0 0 0 0 5.6628 0 0 0 0 0 0 A0A8I3NF40 A0A8I3NF40_CANLF Uncharacterized protein RAB23 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DTAGQEEFDAITKA;EDPELMHSSSNKIGVF;GKSSMIQRYCKGIFTKD 3 19.8 0.8125 0.21141 10.1135 10.1037 10.0751 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NF42 A0A8I3NF42_CANLF Tripartite motif containing 68 TRIM68 Canis lupus familiaris (Dog) (Canis familiaris) protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CETCSQSSEHEAHSVV;VGVFLDYEAH 2 5.4 0.99427 -0.56222 0 7.7418 0 0 0 0 0 0 0 0 0 0 0 0 9.56586 A0A8I3NF47 A0A8I3NF47_CANLF Cytochrome c oxidase assembly factor COX14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] LAYRYFQWR 1 12.5 0.99007 -0.21242 0 0 0 0 0 0 0 0 0 0 0 0 0 9.36019 0 A0A8I3NF51 A0A8I3NF51_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) serine-type endopeptidase inhibitor activity [GO:0004867] FFCVDQWEFGLHIKFYKYGK 1 37 0.96137 0.04875 0 0 0 6.89942 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NF60 A0A8I3NF60_CANLF Glucose-6-phosphatase (EC 3.1.3.9) G6PC1 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156] endoplasmic reticulum membrane [GO:0005789] glucose-6-phosphatase activity [GO:0004346] KLSKWFPFR;METFHLYPSG;VHIDTTPFASLLKNVGTLF 3 10.9 1.0037 -1.0663 0 0 0 7.4876 0 0 0 0 0 0 0 0 0 11.4223 0 A0A8I3NF74 A0A8I3NF74_CANLF Anaphase promoting complex subunit 1 ANAPC1 Canis lupus familiaris (Dog) (Canis familiaris) protein K11-linked ubiquitination [GO:0070979] anaphase-promoting complex [GO:0005680] EEEDDGMNDMNQEVMS;LGFRFAGSENLSAFNCLH;MLVLEGSGNL;PSFFTPEPPSI;SDDDWEYLLNSDYH;TGGEMNYGF;TPEPPSIYQWVSSCL;VCVHAYLSGQPFEE;YPELSDHEFIE 9 6.8 0.98874 0.028099 0 0 12.3249 0 13.1243 7.33914 0 6.30725 0 11.7006 11.9011 13.0387 0 12.1595 10.6663 A0A8I3NF75 A0A8I3NF75_CANLF Uncharacterized protein RRN3 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase I promoter [GO:0006361] RNA polymerase I general transcription initiation factor activity [GO:0001181] EQLISILLRLQW;IKEGDVDVSDSDDEDDT;VSDSDDEDDTIDTCH 3 11.4 0.9393 0.1001 0 0 6.69627 0 0 0 0 0 0 0 0 0 7.30268 0 0 A0A8I3NF76 A0A8I3NF76_CANLF "Sentan, cilia apical structure protein" SNTN Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] transition metal ion binding [GO:0046914] TKPKYKDLL 1 6.1 0.99237 -0.27195 0 0 0 0 0 0 0 0 11.401 0 0 0 0 0 0 A0A8I3NF83 A0A8I3NF83_CANLF Epithelial stromal interaction 1 EPSTI1 Canis lupus familiaris (Dog) (Canis familiaris) SSTWARSWAYKDSLKEEE 1 6.3 0.9655 0.048313 0 8.82047 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NF90 A0A8I3NF90_CANLF Fibronectin type III domain containing 8 FNDC8 Canis lupus familiaris (Dog) (Canis familiaris) KPFPNPKSMN 1 3.1 0.99026 -0.26643 0 0 0 0 0 0 0 0 10.1857 0 0 0 0 0 0 A0A8I3NF98 A0A8I3NF98_CANLF V-type proton ATPase subunit G ATP6V1G1 Canis lupus familiaris (Dog) (Canis familiaris) vacuolar proton-transporting V-type ATPase complex [GO:0016471] "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" HGSCSTEV;KNRRLKQAKEEAQAEIEQ;LLQAEKRAAEKVSEARKR 3 37.3 1.003 -1.006 0 0 0 0 0 0 0 0 5.01507 0 0 6.9305 0 6.23088 9.28956 A0A8I3NFA9 A0A8I3NFA9_CANLF Phosducin like PDCL Canis lupus familiaris (Dog) (Canis familiaris) heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601] cytoplasm [GO:0005737] EDQDDEEFLQ;GVINDWRRFKQLETEQ;TLDDKLLGEKLQ 3 12.6 0.98979 -0.21545 0 0 0 0 0 7.2521 0 0 6.80813 0 0 0 0 0 0 A0A8I3NFB4 A0A8I3NFB4_CANLF Transmembrane protein 236 TMEM236 Canis lupus familiaris (Dog) (Canis familiaris) DLPVSLVLTSLIVVDIIEKLRIYPL;IWVPIKVLLYKKYRLYKKIKGWRPV;IYFNYLTKIW 3 17.1 0.99205 -0.54038 0 0 0 0 0 0 0 4.74712 0 0 0 0 10.5972 0 6.48102 A0A8I3NFB6 A0A8I3NFB6_CANLF Ciliogenesis associated kinase 1 CILK1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721] ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; fibrillar center [GO:0001650] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DSDDWADLDDLDF;EDLLKMLAGLE;LLKMLAGLEPKN;YVSTRWYRA 4 5.6 0.99198 -0.14057 8.76471 0 0 0 0 0 8.09556 0 10.8201 0 0 0 0 0 0 A0A8I3NFB8 A0A8I3NFB8_CANLF Steroidogenic factor 1 (Nuclear receptor subfamily 5 group A member 1) NR5A1 Canis lupus familiaris (Dog) (Canis familiaris) hormone-mediated signaling pathway [GO:0009755]; tissue development [GO:0009888] RNA polymerase II transcription regulator complex [GO:0090575] nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] LPMAVPSAHGPLAGYLYPSF;VGMRLEAVRADR 2 7.6 0.94349 0.10059 7.37095 0 0 0 0 0 10.8877 0 0 0 0 0 0 0 0 A0A8I3NFH3 A0A8I3NFH3_CANLF E3 ubiquitin protein ligase (EC 2.3.2.27) RNF40 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; protein ubiquitination [GO:0016567] HULC complex [GO:0033503]; nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] LVPSEEDVQAL;VEELCQRVYSRGD 2 2.7 0.921 0.11542 12.036 0 4.42425 0 0 0 0 0 12.1447 0 0 3.56255 5.95306 4.00657 4.8776 A0A8I3NFH4 A0A8I3NFH4_CANLF Netrin G1 NTNG1 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888] basement membrane [GO:0005604] FWQSATWKEYPKPLQ;PPLLLLLL;VGEIFVDELHLARYFY;VTVSSVMQP 4 10.9 0.99044 -0.21543 0 0 0 0 0 0 0 0 0 0 0 0 6.4664 0 0 A0A8I3NFH6 A0A8I3NFH6_CANLF Calcium-binding and spermatid-specific protein 1 CABS1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; spermatogenesis [GO:0007283] acrosomal vesicle [GO:0001669]; membrane [GO:0016020]; mitochondrion [GO:0005739]; sperm principal piece [GO:0097228] calcium ion binding [GO:0005509] DSSTLTNEDLSENN 1 3.5 0.93649 0.060873 0 0 0 0 0 0 0 0 0 0 0 0 0 5.87231 0 A0A8I3NFI0 A0A8I3NFI0_CANLF ABI family member 3 ABI3 Canis lupus familiaris (Dog) (Canis familiaris) defense response to tumor cell [GO:0002357]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of cellular senescence [GO:2000774]; regulation of cell migration [GO:0030334] lamellipodium [GO:0030027]; SCAR complex [GO:0031209] identical protein binding [GO:0042802] SSASSLASAGSAEGVGG;YPYTRQKDN 2 7.1 0.29412 0.63868 0 0 14.7801 0 0 0 14.7337 0 0 13.6843 0 13.6202 15.2155 0 14.367 A0A8I3NFI3 A0A8I3NFI3_CANLF procollagen-proline 4-dioxygenase (EC 1.14.11.2) P4HA2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] DSPHIVRYYDV;EAGLATQE;HFDFSRKNEQDA;NSAAGFIA;PVDYLPERDVY;WDSPHIVR 6 9.5 1.001 -2.7199 0 0 0 0 0 0 0 0 0 0 0 0 8.98752 0 9.59403 A0A8I3NFJ1 A0A8I3NFJ1_CANLF Cell wall biogenesis 43 C-terminal homolog CWH43 Canis lupus familiaris (Dog) (Canis familiaris) GGAVLLGL;IFLGYITSAP;LGQILLLVL 3 4.3 1.0021 -1.2419 0 10.4074 0 0 0 0 7.85131 8.4154 0 7.98476 0 0 0 0 0 A0A8I3NFJ3 A0A8I3NFJ3_CANLF Vitamin D-binding protein (Gc-globulin) (Group-specific component) GC Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] actin binding [GO:0003779]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482] AECCDSEDSTGCMNA;CCESTSEDCM;EINTVLSKCCESTS;LPEYTVKICDNLSTKNSK;LSRRTHLPEVFLSKIL;MVLYSRKFPSSTFEQI;VAFVHALERGRDYEKEK;YTVKICDNLSTKN 8 21.5 1.0043 -1.098 0 0 10.2322 0 0 0 4.85215 9.59731 7.50295 4.5784 0 0 0 7.85947 0 A0A8I3NFJ7 A0A8I3NFJ7_CANLF F-box protein 30 FBXO30 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DLVLECVARYQPKQRSM;EDKAVDTSDLEVAED;GVQPCVST;ISDSRMVDVYHID;ISDSRMVDVYHIDFGTQTF;TAALLFCLGD 6 9.5 1.0024 -1.1682 8.78875 0 0 0 0 8.89321 0 0 10.2098 0 0 3.86839 3.59491 9.6418 0 A0A8I3NFJ8 A0A8I3NFJ8_CANLF A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] anchoring junction [GO:0070161]; dendritic spine [GO:0043197]; perikaryon [GO:0043204]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076] A-type (transient outward) potassium channel activity [GO:0005250]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030] PGHAKELPCGERYAVAFFC;VAFFCLDTACVM 2 7.4 0.95244 0.049538 6.61411 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NFK3 A0A8I3NFK3_CANLF RAMA domain-containing protein ANKRD31 Canis lupus familiaris (Dog) (Canis familiaris) CFCDDCNTVD;ETHIQSLDLSDNQE;ILPKILVCEDQTTNNSSTKN;KNREQIRRNQNLAGK;KSLLVVAKKQKKITEKI;NVEPICHREEGG;QETTHKASVLLS;QKSLLVVAKKQKKITEKIQN;QQEAVNLSDSDNTIGPE;SGMCKGTSP;TIHDTVFYSTDN;VEKVNEREDPKKN;WCFCDDCNTVDP;YEQCKCKTSFDHSHGNSEHTS 14 9.2 1.0042 -1.0999 0 3.79088 11.3995 6.20596 8.46667 13.2653 4.84524 0 4.15769 0 0 4.09677 11.0934 10.9577 0 A0A8I3NFK7 A0A8I3NFK7_CANLF Disintegrin and metalloproteinase domain-containing protein 2 (Fertilin subunit beta) (PH-30) (PH30-beta) ADAM2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] CDCGSDCE;CTPRKCNERGICNNKKNCH;DCETVSNTCCNPATCT;EQCDCGSDCETVSNTCCNPATC;EQGEQCDCGSDCETVSNTCCN;FLIILSVLIIILVKVYFQRKKWRTE;GATFQGKMCDSHYGGGVALHPRTI;LIPFLIILSVLIIILVKV;YFQRKKWRTEEYTKTSDD 9 15.6 1.0025 -0.73842 4.28059 0 0 0 9.38355 0 10.555 2.51904 0 0 0 0 8.54951 0 7.47841 A0A8I3NFM0 A0A8I3NFM0_CANLF EF-hand calcium binding domain 5 EFCAB5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EFEEIDLPEFWGDMDN;EVKGRSAFN;FWNHSLKKSDQNGSFL;GVNMGTTAEQGLYRE;QETHTGSTPEQG;SEQGSRRQSVIEQEPLK 6 6.2 1.0026 -1.1824 0 0 0 5.72454 0 7.74389 0 0 10.0067 0 0 0 6.94275 0 0 A0A8I3NFN4 A0A8I3NFN4_CANLF Zinc finger protein 689 ZNF689 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HKKPGAVS;VGFQHYPEI 2 4.2 1.0018 -1.2942 0 0 9.03815 0 0 0 0 0 0 0 9.98499 0 0 0 0 A0A8I3NFN7 A0A8I3NFN7_CANLF Uncharacterized protein RNF135 Canis lupus familiaris (Dog) (Canis familiaris) regulation of innate immune response [GO:0045088] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin-protein transferase activity [GO:0004842] QFAQWAIS 1 2 0.99068 -0.51132 0 0 0 0 0 0 0 0 0 0 10.5626 0 0 0 0 A0A8I3NFN8 A0A8I3NFN8_CANLF Pleckstrin and Sec7 domain containing 4 PSD4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] CRPLVAAFGGPQRP;DEATKGTLEAPGCWT;EGQRPQAGDKLANGVS;GDGTADSSGH;PGGDSSDP;PSPEGWQT 6 7.2 1.0043 -2.0195 0 0 0 10.0753 0 11.3557 0 0 0 7.29453 0 0 0 9.82971 6.35382 A0A8I3NFP6 A0A8I3NFP6_CANLF Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) LOC100682736 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] microtubule plus-end binding [GO:0051010] DMLAWINESL;PSLVALALNKLKKPLR;VQWFKKFF 3 16.2 0.95624 0.049233 0 0 0 0 0 0 0 4.31665 0 0 0 0 0 0 0 A0A8I3NFP7 A0A8I3NFP7_CANLF Max dimerization protein 3 (Max-associated protein 3) MXD3 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" LKEKLRSKQ 1 4.4 1.0044 -0.80421 0 0 0 0 0 0 0 0 8.8786 0 0 0 0 0 0 A0A8I3NFQ5 A0A8I3NFQ5_CANLF Speedy/RINGO cell cycle regulator family member A SPDYA Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein kinase binding [GO:0019901] VIQRQEMTAFFKLFDDD 1 6 0.97675 0.046227 0 5.97636 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NFQ7 A0A8I3NFQ7_CANLF Proline rich 5 PRR5 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGD;GGGGGGGG;RNTITLSVK 3 3.2 0.98508 -0.25927 0 0 12.0185 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NFR6 A0A8I3NFR6_CANLF Stromal interaction molecule 1 STIM1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874]; regulation of transport [GO:0051049]; store-operated calcium entry [GO:0002115] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509] LLVAKEGAEKIKKKRNTLFGT;VLKMTDRSHRQ;YAEEELEQVR 3 7.8 0.9873 -0.23509 0 0 6.53741 0 0 0 0 0 0 0 0 9.45413 0 0 0 A0A8I3NFR8 A0A8I3NFR8_CANLF Myosin XVIIIA MYO18A Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAIEDEMESDENEDL;DLITSPTSYWKSLAP;ERLFSYYGPQEGDKKGQR;GWLSYTKQNPA;HKDGFSLGSQLKSEELSLP;KKHELEMDLE;KQMEVQLEEEYEDKQ;QEFEDKLEVEQQ;RLEMEMERMRQTHSKEVE;SDENEDLITSPTS;TGMAAVKKKSL;VQLEEEYEDKQ 12 7.1 0.99358 -0.064136 0 0 0 0 0 10.9833 0 0 10.7796 0 0 0 0 0 0 A0A8I3NFT0 A0A8I3NFT0_CANLF Homeobox protein MOX-1 (Mesenchyme homeobox 1) MEOX1 Canis lupus familiaris (Dog) (Canis familiaris) sclerotome development [GO:0061056]; somite specification [GO:0001757] cytoplasm [GO:0005737]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LRSVRIKTLKRRRL;VRIKTLKRRRLSGRRQ 2 6.8 0.98441 -0.23995 0 0 0 0 0 0 0 0 0 0 0 0 0 4.82151 0 A0A8I3NFT1 A0A8I3NFT1_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] LSPRRTRRRKVIRPRAENF 1 22.4 0.95154 0.04941 0 0 0 0 0 0 0 0 0 0 0 4.76341 0 0 0 A0A8I3NFT9 A0A8I3NFT9_CANLF Reticulon 4 receptor like 1 RTN4RL1 Canis lupus familiaris (Dog) (Canis familiaris) corpus callosum development [GO:0022038]; negative regulation of axon regeneration [GO:0048681] cell surface [GO:0009986]; plasma membrane [GO:0005886] chondroitin sulfate binding [GO:0035374]; heparin binding [GO:0008201]; signaling receptor activity [GO:0038023] FNNSLSEL;LRRLTTLFLF;LSHLFLHGNKLWSLGQ;SERIFLQNNRIT;TLLQQGHFSPAMVTLWIYSNNIT 5 15.1 1.0014 -0.69501 0 0 0 0 0 5.25531 6.32882 0 0 0 0 0 11.3269 0 10.3476 A0A8I3NFU4 A0A8I3NFU4_CANLF Glycine receptor beta GLRB Canis lupus familiaris (Dog) (Canis familiaris) "neuropeptide signaling pathway [GO:0007218]; synaptic transmission, glycinergic [GO:0060012]" neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ETTMDYRVNIFLRQKWNDP;VGFYMMGVYAPTLLIVVLSWL 2 13.2 0.97669 0.047759 4.59997 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NFW4 A0A8I3NFW4_CANLF "ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon)" ATP5IF1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] ATPase inhibitor activity [GO:0042030] ALQTRGFGSERSEDP;LQTRGFGSERSE 2 21.4 0.99066 -0.22203 0 0 0 0 0 9.05167 0 0 0 0 0 0 5.283 0 0 A0A8I3NFW7 A0A8I3NFW7_CANLF Olfactory receptor OR2A12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;FYSLTLMGNGLILGL;LFNPMLNP 3 11.6 0.95231 0.053901 0 7.46638 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NFW8 A0A8I3NFW8_CANLF BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BTB/POZ domain-containing protein TNFAIP1) TNFAIP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] Cul3-RING ubiquitin ligase complex [GO:0031463]; endosome [GO:0005768]; nucleus [GO:0005634] ubiquitin-protein transferase activity [GO:0004842] FPEARIYEETLNVL;LRDRVRRIHVKRYSTY;VQLNVGGSLYYTT 3 13.6 0.98401 -0.24476 0 0 0 0 0 0 5.87485 0 0 0 0 0 0 0 0 A0A8I3NFX7 A0A8I3NFX7_CANLF "rRNA methyltransferase 2, mitochondrial" MRM2 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254]; RNA methylation [GO:0001510] methyltransferase activity [GO:0008168] GRADVILSDMA;LLEMDERHRIL 2 8.9 0.98977 -0.21508 0 0 0 0 0 0 10.3829 0 0 0 3.07204 0 0 0 0 A0A8I3NFX9 A0A8I3NFX9_CANLF Leiomodin 3 LMOD3 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] tropomyosin binding [GO:0005523] ADAEEDEGDEDDEDDDEEDED;ADAEEDEGDEDDEDDDEEDEDD;ADAEEDEGDEDDEDDDEEDEDDE;AEEDEGDEDDEDDDEEDE;AEEDEGDEDDEDDDEEDED;AEEDEGDEDDEDDDEEDEDDED;DAEEDEGDEDDEDDDEEDEDD;DDDEEDEDDEDEDEEEEAD;DEDDDEEDEDDEDEDEEEEADS;EDEDEEEE;EDEGDEDDEDD;EDEGDEDDEDDDEEDE;EDEGDEDDEDDDEEDEDDEDE;EEDEDDEDEDEEEEADSE;EEQKQQQLKEQRKLI;ETDDADAEEDEGDEDDEDDDE;GDEDDEDDDEEDEDDEDED;HKSLMDYMYWQKASRRMLEDERVP;NDVQETDDADAEEDEGDEDDE;QETDDADAEEDEGDEDDEDDD 20 14.1 0.088235 0.89411 0 6.66064 8.49737 6.48188 6.2149 6.17219 4.22966 8.44108 9.53879 5.89949 6.07662 9.28725 6.33555 8.13011 9.93279 A0A8I3NFY9 A0A8I3NFY9_CANLF Uncharacterized protein ZNF34 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ELDQLQGAVPQ;HGARTEFKELSSEEML;LETYRNLVSL;LVSLGAGPAGPKPG 4 8.6 1.0019 -0.64796 0 0 0 0 0 0 10.6917 0 0 0 0 0 3.77989 8.98954 11.4708 A0A8I3NFZ3 A0A8I3NFZ3_CANLF Sperm associated microtubule inner protein 4 SPMIP4 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813] AQKRFHKS;DSLMPKPPNST 2 3.2 0.98809 -0.22436 4.0648 4.5001 0 0 6.55897 0 0 0 0 0 0 0 9.49193 0 0 A0A8I3NFZ5 A0A8I3NFZ5_CANLF TBC1 domain family member 10C TBC1D10C Canis lupus familiaris (Dog) (Canis familiaris) KNSPGTYQELAEA 1 3.1 0.94774 0.079903 0 0 0 0 6.69877 0 0 0 0 0 0 0 0 0 0 A0A8I3NG04 A0A8I3NG04_CANLF Scaffold attachment factor B2 SAFB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] MEDRYRPDFPRPDHRFHDFDHRDRG;VADRRGGSAASRPP;VIKKEEKMEKKEEKKPEDIKKE 3 7 0.99436 -0.1644 0 0 9.81479 0 0 0 0 0 0 0 0 11.1638 0 0 0 A0A8I3NG09 A0A8I3NG09_CANLF Exostosin like glycosyltransferase 2 EXTL2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] glycosyltransferase activity [GO:0016757] LRFSLVVILVLLLV;PAAVHALI;VGEKGPDEL 3 9.8 1.0019 -1.2616 0 0 7.38215 0 0 0 1.96414 0 10.9799 0 0 0 0 0 0 A0A8I3NG10 A0A8I3NG10_CANLF F-box protein 47 FBXO47 Canis lupus familiaris (Dog) (Canis familiaris) LILSGNNI;TDESSLKDLADA 2 4.4 0.98991 -0.31552 0 11.8675 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NG17 A0A8I3NG17_CANLF "Isocitrate dehydrogenase [NAD] subunit, mitochondrial" IDH3A Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] GVTPSGNIGANG;IRENTEGEYSGIEHV;SQFDVLVMP 3 9.8 1.0036 -1.0645 0 0 0 0 0 9.24453 0 0 0 0 0 0 10.6137 0 0 A0A8I3NG18 A0A8I3NG18_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGLSIPTRVIP 1 15.3 0.98945 -0.26153 0 0 0 0 0 0 0 0 0 0 0 16.3354 0 0 0 A0A8I3NG26 A0A8I3NG26_CANLF Zinc finger protein 875 ZNF570 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HQRIHLGESL;SQSSKDTAISHEKSQ 2 4.4 0.99076 -0.2135 0 0 0 9.73672 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NG28 A0A8I3NG28_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LLESLDNQRRRKRRI 1 26.3 0.95077 0.053874 0 0 0 0 0 0 0 0 4.39938 0 0 0 0 0 0 A0A8I3NG41 A0A8I3NG41_CANLF Peroxisomal ATPase PEX6 (Peroxin-6) PEX6 Canis lupus familiaris (Dog) (Canis familiaris) "protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; protein unfolding [GO:0043335]" cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; photoreceptor cell cilium [GO:0097733] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; ubiquitin-modified protein reader activity [GO:0140036] AGESPAGPALLVAALEGPDAETE;ATTSQAQDLP;EDKGSCSVLSGPLFAKELH;TELRGRAK 4 6.1 1.0032 -0.8772 0 7.94965 0 0 0 8.94813 11.6368 0 0 0 0 0 0 10.2133 0 A0A8I3NG48 A0A8I3NG48_CANLF Leucine rich repeat containing 24 LRRC24 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of synapse assembly [GO:0051965] PTCVSGGT 1 1.4 1.0041 -1.1044 0 0 0 0 9.59192 0 0 0 0 0 0 0 0 0 0 A0A8I3NG52 A0A8I3NG52_CANLF ENAH actin regulator ENAH Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779]; SH3 domain binding [GO:0017124] EVLNSQETAQSKVAATQ;ISKASSTST;PSLAPRSHCGSQASPP;RLDREREQRERQEQREREQRERQ;VGSAFHPVLPH 5 8.1 1.0025 -1.1782 6.68145 9.28445 0 0 0 0 0 0 0 0 0 0 0 0 14.5853 A0A8I3NG66 A0A8I3NG66_CANLF Zinc finger and BTB domain containing 7B ZBTB7B Canis lupus familiaris (Dog) (Canis familiaris) "adaptive thermogenesis [GO:1990845]; lactation [GO:0007595]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of gene expression [GO:0010629]; negative regulation of NK T cell proliferation [GO:0051141]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NK T cell differentiation [GO:0001865]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of SREBP signaling pathway [GO:2000640]; response to insulin [GO:0032868]" nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity [GO:0001217]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALMGAGGG;LQGSGLEAPSPDEDD;SPDEDDCE 3 4.6 1.0028 -2.5171 0 0 0 4.06411 0 0 0 0 0 0 0 0 0 0 8.94111 A0A8I3NG69 A0A8I3NG69_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) SSH3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721] GNALTWAAHYQ;LVASRTQAFQEQ;PQLSKAKGGRRC;QALELRLGRPLQQYRDFIDNQ;RRCGKGPWPALKSRQS;VFPRQPSWRQHGPP 6 14.1 0.94009 0.060964 4.84016 0 0 0 0 5.48327 0 0 0 0 0 0 0 0 0 A0A8I3NG84 A0A8I3NG84_CANLF BCL3 transcription coactivator BCL3 Canis lupus familiaris (Dog) (Canis familiaris) "antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T cell apoptotic process [GO:0070231]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]" Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] PDSPAVPA;PIYPTPNMGSLF;VARSRRVIDILRG 3 7.3 1.0033 -1.6903 8.03826 0 0 0 0 0 0 6.18261 0 0 0 0 0 0 0 A0A8I3NG85 A0A8I3NG85_CANLF Transmembrane protein 249 TMEM249 Canis lupus familiaris (Dog) (Canis familiaris) GVVSQVRKQETW 1 5 0.94242 0.05044 0 0 0 9.36394 0 0 0 0 0 0 0 0 0 10.223 0 A0A8I3NG92 A0A8I3NG92_CANLF Coronin CORO6 Canis lupus familiaris (Dog) (Canis familiaris) LLSTGFSRMSERQ;NGSLLATTC;TDEPPFVHYL;VEAGGGGA;VMVWQIPDYTPV 5 11 1.0031 -0.83923 0 6.68075 10.91 0 0 0 0 10.9593 0 0 0 0 10.1379 0 0 A0A8I3NG96 A0A8I3NG96_CANLF GTPase activating Rap/RanGAP domain like 3 GARNL3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] CYNYSCIY;EPQCFCSN;INTHHSRELRIVV;IVFQEGEEPSPAFKPSMIRSHFT;PKPKSKARK;SHFTHIFALVRYD;SLSFGIQPLQTWPTKD;SLSLSRMEI;VEASRVNF 9 10.5 0.99918 -3.0634 0 0 0 9.9413 0 11.8219 12.6806 12.6576 12.7317 8.83023 8.67257 0 11.901 9.44296 0 A0A8I3NG98 A0A8I3NG98_CANLF Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]" catalytic step 2 spliceosome [GO:0071013] mRNA 3'-UTR binding [GO:0003730]; single-stranded telomeric DNA binding [GO:0043047] EEHHLRDY;EVAILEVALV 2 6.9 0.99411 -0.13126 0 0 0 9.22304 0 0 0 0 10.1834 0 0 0 0 0 0 A0A8I3NG99 A0A8I3NG99_CANLF IQ motif containing GTPase activating protein 2 IQGAP2 Canis lupus familiaris (Dog) (Canis familiaris) LHEKGVLLGIDD;VGSENPPLTVIRKFVHLL 2 2.8 0.93333 0.098753 0 0 0 0 0 0 0 0 4.58982 0 0 5.20918 0 0 0 A0A8I3NGA2 A0A8I3NGA2_CANLF A-kinase anchoring protein 11 AKAP11 Canis lupus familiaris (Dog) (Canis familiaris) EVESSEDEEHPE;LSESDEPDDKDEDPEDDGEG;LVASEAEVTELY;PYNDGINITALKSQCDAASQ;QDLAAVSVELPDL;SLKAKLELPKIPV 6 4.8 0.98725 -0.35142 0 7.56902 0 7.48083 0 0 9.20109 0 0 0 10.1325 0 9.77921 0 0 A0A8I3NGA3 A0A8I3NGA3_CANLF catechol O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) TOMT Canis lupus familiaris (Dog) (Canis familiaris) auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; methylation [GO:0032259]; positive regulation of protein import [GO:1904591]; sensory perception of sound [GO:0007605] apical part of cell [GO:0045177]; endoplasmic reticulum [GO:0005783] catechol O-methyltransferase activity [GO:0016206] LVLLAHRPRCYLRD;LVVTLLVRYRHYFRLLVR;VEEKTPACVLELGTH 3 18.2 0.99305 -0.16795 5.82868 0 0 0 0 0 0 0 0 0 0 7.96486 7.90761 0 0 A0A8I3NGA9 A0A8I3NGA9_CANLF Post-GPI attachment to proteins factor 3 PGAP3 Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] Golgi membrane [GO:0000139] RALLLLMLTAH;TCQDDCKYECMWV;VLFFSFLEDDSL 3 13.4 1.0041 -0.82706 9.86802 0 0 0 0 0 0 10.9218 0 12.6099 12.6457 0 0 0 0 A0A8I3NGB9 A0A8I3NGB9_CANLF Chitinase domain-containing protein 1 CHID1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] endomembrane system [GO:0012505] chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492] HVTDQLGMF;MTYDYPTAQQPGPNAPLSW 2 7.7 0.98879 -0.26278 0 0 0 0 0 0 0 0 0 0 0 0 9.72986 0 0 A0A8I3NGC6 A0A8I3NGC6_CANLF Homeobox domain-containing protein LOC119870089 Canis lupus familiaris (Dog) (Canis familiaris) cell development [GO:0048468]; muscle organ development [GO:0007517] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LAQGKDTLQ;QGNAERLSVSSDD 2 6.2 0.98409 -0.24749 0 0 0 0 0 0 0 0 12.4235 0 0 0 0 0 0 A0A8I3NGC9 A0A8I3NGC9_CANLF LHFPL tetraspan subfamily member 5 LHFPL5 Canis lupus familiaris (Dog) (Canis familiaris) detection of mechanical stimulus involved in sensory perception [GO:0050974]; sensory perception of sound [GO:0007605] plasma membrane [GO:0005886] KLLPAQEAA;TVYKICAWMQL 2 9.1 0.99412 -0.13158 0 0 0 9.72971 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NGE9 A0A8I3NGE9_CANLF Nipsnap homolog 3A NIPSNAP3A Canis lupus familiaris (Dog) (Canis familiaris) MNKVFHIWKYDNFA 1 7.1 0.9351 0.060938 0 0 0 0 0 0 0 0 0 7.71596 0 0 0 0 0 A0A8I3NGF3 A0A8I3NGF3_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; plasma membrane [GO:0005886] DGDHICSVRDDEFKFQG;DITQLEKEVNVCKQYYQELLKSAER;DLGTITNKCE;FSQAATSASVPT;KEQFEKSHAQLLQ;KHNYEVELESL;KLQREVDRITKT;NQDPQQSE;QREVDRITKTH;RKAEKDMRELKYEL;TELADCLL;TIEAYRAAMQTQWSWILQL;VIADKNNIENLI;YNLYISEVRNIRL 14 6.6 1.0021 -1.3951 2.91284 0 0 9.34871 8.37682 8.66459 0 0 0 0 0 0 0 8.37439 4.79478 A0A8I3NGG8 A0A8I3NGG8_CANLF Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) BCAT1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid biosynthetic process [GO:0008652]; branched-chain amino acid biosynthetic process [GO:0009082] branched-chain-amino-acid transaminase activity [GO:0004084] GVKKPTKALLFVI;LARQDCNNGCSPECTGEAGS;LKEKPDPNALVFG;MNLFLYWI 4 13.6 0.97283 0.048206 0 0 0 0 0 0 0 7.95041 0 0 0 0 0 0 0 A0A8I3NGH9 A0A8I3NGH9_CANLF Uncharacterized protein LOC100688619 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] CHERVALPV;LGLCSPLGRLKG 2 10.2 0.99645 -0.57553 0 0 0 0 0 9.44721 0 0 0 0 0 0 0 0 0 A0A8I3NGK1 A0A8I3NGK1_CANLF Nucleoredoxin (EC 1.8.1.8) NXN Canis lupus familiaris (Dog) (Canis familiaris) thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] DQDQRQWQDFVRDMPWLALPYKEKH;FLPRLPAGKNR;GISLLGLYFGCSLSAP;GRGSGSCCC;LCPCGRGSGSCCCAF;LGLYFGCSLSAPCAQLSGSL;PGPGAGAG 7 17.2 1.0025 -1.0216 0 0 0 8.90406 7.75081 0 8.32211 0 0 0 0 0 0 0 9.59154 A0A8I3NGK3 A0A8I3NGK3_CANLF Roundabout guidance receptor 3 Canis lupus familiaris (Dog) (Canis familiaris) DLQLNLMANGTLYI;DLQLNLMANGTLYIASV;GDPGAWSQ;GPEEDLEGSS;GSPVWLPCR;HTLKSDAGMYVCVA;PAPYPWLADSWP;VLRAPAFLAGSG;VSGLQPNTIYLFL 9 6.9 1.0039 -1.6788 0 7.29545 0 0 11.4124 9.46324 6.15733 11.7057 10.3669 0 4.66784 4.97274 5.37865 9.77896 0 A0A8I3NGK9 A0A8I3NGK9_CANLF Synapsin III SYN3 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269]; synaptic vesicle clustering [GO:0097091] glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synaptic vesicle membrane [GO:0030672] ATP binding [GO:0005524] AHTDWTKY;FCSKPWVFSQLIKIFHSLGPEK;SAMLEQVAMTERY 3 7.4 0.99429 -0.15925 0 0 0 0 6.83681 10.202 0 8.88114 0 0 0 0 0 0 0 A0A8I3NGL1 A0A8I3NGL1_CANLF G-protein coupled receptors family 2 profile 2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EVHGDLSLAE;LFYATGWGAPVAIV;RSGTHRERLLCQEAGKG;SPSRLVPQPPRPALCWLQRPSPG;TVKPVLVLLPVLGL 5 11.1 1.0023 -1.0188 7.53232 0 9.58851 0 0 0 0 10.1872 0 4.42136 0 0 0 0 0 A0A8I3NGL4 A0A8I3NGL4_CANLF ADAM metallopeptidase domain 30 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] FVLIPIFFNV;IVEENEDCDCGSREEC;QFFDHVNSAALC;VGYHKAMIPM;VGYHKAMIPMGIP;YMCREEDNECDLAEY 6 9.5 0.99364 -0.074206 0 0 3.80095 0 0 0 0 0 0 9.01399 0 0 11.2713 0 11.2556 A0A8I3NGN3 A0A8I3NGN3_CANLF F-box and leucine rich repeat protein 8 FBXL8 Canis lupus familiaris (Dog) (Canis familiaris) AVHAICRAASAL;LRSYTLKLTREPHPWM;PYLSACLDHVHNLQLEF;TELLTALA;VCFAARHY 5 16.3 1.0023 -1.2251 0 0 0 0 0 0 8.09761 0 0 6.81967 0 0 0 0 5.54009 A0A8I3NGN4 A0A8I3NGN4_CANLF Glutaredoxin-like protein C11H5orf63 Canis lupus familiaris (Dog) (Canis familiaris) ERYKFDIPVFHLNGQ 1 12.6 0.98402 -0.24311 0 0 8.80003 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NGP8 A0A8I3NGP8_CANLF Small ribosomal subunit protein uS19 (40S ribosomal protein S15) RPS15 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] SLLKRLRKAKKE 1 8.3 0.953 0.05044 0 5.7304 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NGQ2 A0A8I3NGQ2_CANLF Leucine rich repeat containing 2 LRRC2 Canis lupus familiaris (Dog) (Canis familiaris) FLLYKNKLTYL;RILDLPKNQISRLPAEI 2 7.5 0.95036 0.081718 0 0 0 0 0 0 0 0 0 0 5.17636 0 0 7.76394 0 A0A8I3NGR1 A0A8I3NGR1_CANLF Uncharacterized protein IGFBPL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell growth [GO:0001558] extracellular region [GO:0005576] insulin-like growth factor binding [GO:0005520] PALGPLLLLLL 1 4 0.98539 0.035491 0 0 0 0 0 0 0 0 0 0 0 3.28613 0 0 0 A0A8I3NGR9 A0A8I3NGR9_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" EDEM1 Canis lupus familiaris (Dog) (Canis familiaris) "carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; mannoprotein catabolic process [GO:0006058]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; protein targeting to ER [GO:0045047]; ubiquitin-dependent protein catabolic process [GO:0006511]" aggresome [GO:0016235]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]; misfolded protein binding [GO:0051787]" DTLAIMGNSSEFQK;IDKSKEDRMESF;PGPGAGAG;TIRVLGSLLSAH 4 6.9 0.99174 -0.17685 0 0 0 0 4.79213 0 0 0 0 0 0 3.82263 0 0 0 A0A8I3NGS4 A0A8I3NGS4_CANLF BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) BAIAP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane organization [GO:0007009]; regulation of actin cytoskeleton organization [GO:0032956] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; membrane [GO:0016020]; ruffle [GO:0001726] cytoskeletal anchor activity [GO:0008093] DPPQGPPL;DVLFQMAEVHRQIQNQLEEML;KYSDKELQYIDAISNKQGELENYV;LVPEARDGWHYG;TEQRSKGDALDK 5 9.6 1.0037 -1.1044 0 0 0 0 0 0 0 6.61974 0 0 0 0 0 0 0 A0A8I3NGS9 A0A8I3NGS9_CANLF Fibrosin FBRS Canis lupus familiaris (Dog) (Canis familiaris) ARPLAFQFHQHNHQHQ;KWCAMHVRVAYM;LFRHNPYTAF;PDHFRPPLRKPGKWC;SKTPPGAL;SRGEEEEEEEEGGAD 6 7.4 1.0023 -1.2212 0 9.59475 0 0 8.25988 0 10.0083 0 0 0 0 0 11.9804 0 0 A0A8I3NGV7 A0A8I3NGV7_CANLF Solute carrier family 41 member SLC41A3 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion transport [GO:0015693] membrane [GO:0016020] inorganic cation transmembrane transporter activity [GO:0022890]; monoatomic cation transmembrane transporter activity [GO:0008324] LFAGLGLSGAGVLLNYFQANTGQID;LVCIGFMALIPMWV 2 8.8 0.97692 0.035538 0 0 8.61681 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NGW0 A0A8I3NGW0_CANLF Zinc finger protein 503 ZNF503 Canis lupus familiaris (Dog) (Canis familiaris) G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; neural precursor cell proliferation [GO:0061351] nucleus [GO:0005634] metal ion binding [GO:0046872] ASKGSGGA;GGGGGASK;GGGGGGGA;GGGGGGGG;KHSGGGGG;PGGGGGGG;PYSKSPLPT;SEELLSHLRTH 8 10.3 0.99904 -3.2434 9.87292 0 0 9.35909 0 0 0 0 9.9326 0 0 6.11333 0 10.1828 0 A0A8I3NGX0 A0A8I3NGX0_CANLF Proline rich 14 PRR14 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] GVGVSPPL;KGKEPRASEDQVLSDPETKTMGKVS;PQEETTTLRHR;SPDPLHLCRE;TSSLAPSPDVGPLLQ;VGGGEMARAPPPPRPCLR 6 14.9 1.0028 -1.9062 0 0 0 0 0 11.1724 0 7.38569 0 0 0 0 0 0 0 A0A8I3NGX1 A0A8I3NGX1_CANLF Zinc finger protein 48 ZNF48 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CSFCGKEFPRSSDLVKHRRTHTGE 1 3.9 0.97427 0.041303 0 0 0 0 0 7.54272 0 0 0 0 0 0 0 0 0 A0A8I3NGX9 A0A8I3NGX9_CANLF Zinc finger CCHC-type containing 17 LOC100683619 Canis lupus familiaris (Dog) (Canis familiaris) EEEEEEEEEEEEEEEEEEEEEEEE;KDSKGSEEEEEEEEEEE;PTRNSSRKRKKKKHH;SEEEEEEEEEEEEEEEEEEEEEEEE 4 25.1 0.99033 -0.26188 0 0 0 0 0 0 0 0 0 0 0 0 0 8.86056 0 A0A8I3NGZ7 A0A8I3NGZ7_CANLF HMG box domain-containing protein TCF7 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DNA binding [GO:0003677] MKEMRAKVI;PGHAPAGPA 2 3.3 0.98506 -0.25781 0 0 0 0 0 0 0 0 0 0 8.22415 0 0 0 0 A0A8I3NH13 A0A8I3NH13_CANLF Adhesion G protein-coupled receptor F4 ADGRF4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] LIIYGILVVFRRMMKSRMMAIG;LNAFQGFF;SIAFPTLG;VLDYITCIGLSISIFS;VLSVILPEQLKQ 5 9.5 0.98633 -0.45401 0 0 0 0 0 0 0 0 6.45756 0 0 0 0 9.88075 9.52489 A0A8I3NH17 A0A8I3NH17_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CYMCVFCEYVDIITPDHN 1 15.9 0.97268 0.048313 0 0 9.55591 0 0 0 0 0 0 9.11491 0 0 0 0 0 A0A8I3NH34 A0A8I3NH34_CANLF Interleukin 1 receptor type 1 IL1R1 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] "hydrolase activity [GO:0016787]; interleukin-1, type I, activating receptor activity [GO:0004909]" LPKKASDGKTYDAYIL 1 2.8 0.99113 -0.13749 0 0 0 0 0 0 0 10.6687 0 0 0 0 0 0 0 A0A8I3NH35 A0A8I3NH35_CANLF "Phospholipase B1, membrane-associated (EC 3.1.1.3) (EC 3.1.1.4) (EC 3.1.1.5) (Lysophospholipase) (Phospholipase A2) (Phospholipase B/lipase) (Triacylglycerol lipase)" PLB1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; positive regulation of acrosome reaction [GO:2000344] apical plasma membrane [GO:0016324] phospholipase activity [GO:0004620] GHQRENPPISL;GHQRENPPISLRTMSF;LTAGNGAGSKPGDILDVLTQ;PSQKFHTQLSRALW;SEAGPNVL;SLELQELKQMNWNFQ 6 5 1.0021 -1.2024 11.5362 0 0 0 9.98613 0 13.7229 10.6872 13.9082 13.6262 0 0 11.2257 0 13.309 A0A8I3NH41 A0A8I3NH41_CANLF Grid2 interacting protein GRID2IP Canis lupus familiaris (Dog) (Canis familiaris) DLEPEPEPE;DYEEMSFHDDQG;ESVLPGSP;KKHRARFDEVV;LPETPNPKMMSAVYA;NPKMMSAVYAELESRLNSSFKGK;SETSHMSVKRLRWEQ;SRAPSPQP;TEPEPELDLEPEP 9 9.6 0.9872 -0.26005 0 0 0 9.34842 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NH42 A0A8I3NH42_CANLF "Proteasome 26S subunit, non-ATPase 3" PSMD3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511] "proteasome regulatory particle, lid subcomplex [GO:0008541]" enzyme regulator activity [GO:0030234] IAQKLQLDSP 1 1.9 0.98373 -0.25261 0 0 7.65657 0 6.9542 0 0 0 0 0 7.1982 0 0 0 0 A0A8I3NH48 A0A8I3NH48_CANLF Dynein axonemal heavy chain 8 DNAH8 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVIRQYNKISY;DLLDISNLPMWKP;EAKLTQVIENWTNQNLSF;FYPGVAEHKDISKL;HPGGGRNDIPQRLKRQFTVFN;IEEAYAIL;ILNTLIAQTTHDL;INHTIERILQYY;KLKNFYPGVAEH;LDPLSFLIN;LDQYFEYIQ;LINDLFPGLQLDSSTYVELQ;LKGTESGEIITLMEDSL;LKNKDDIEDIC;LTGEQGTAKTVMVKAYMK;LVPSFDFLSEKLQFYQR;LVRRMLLLKLGVKITYIIKIELDS;PENLKIQFRT;PFRWILDMTWLNLVE;PGEAPPPSDEEGQR;RCLGKYVV;SYLSFINGYKNIYTEKVKHINEQA;TSLKFTNEPPQGI;VHVWDQETPIVLKKIQDCIFLFKEY;VLHKTRKELNLLQK;VPEQAKKLLKLESKLKA 26 8.1 0.97423 0.041303 0 0 0 0 0 0 5.3454 0 0 0 0 0 0 0 0 A0A8I3NH50 A0A8I3NH50_CANLF Nuclear receptor binding SET domain protein 1 NSD1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of peptidyl-serine phosphorylation [GO:0033135] nucleus [GO:0005634] histone H3K36 methyltransferase activity [GO:0046975]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] DKDSPFGNGQSNFSEPLN;EHSSGVAAQGP;ENVCQNCEKLGE;GSNDYLWTHQARVFPY;HDLLLNGCLKSL;NWYCNDCKAGKKPH;PDSSTSTLGNMLE;PLNGCTMQLSTASGTS;QRKPTKKLLE;RRPWWPCRICSDPLINT;TLAQTCWSLGRGQDP;VDDADVDSEMDPEQPVTEDESI 12 6.4 0.9894 -0.30435 14.7686 6.53109 10.1139 0 10.6969 8.33253 0 10.4854 10.2071 0 5.20159 6.13212 14.6633 0 9.76092 A0A8I3NH60 A0A8I3NH60_CANLF Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 Canis lupus familiaris (Dog) (Canis familiaris) "DNA alkylation repair [GO:0006307]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; symbiont-mediated disruption of host cell PML body [GO:0075342]; transcription-coupled nucleotide-excision repair [GO:0006283]" cytosol [GO:0005829]; PML body [GO:0016605]; protein-containing complex [GO:0032991] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039] EDQFCGHQGNDMY;IGVHQEDELLE;MVMPRFYPDRPHQKSVG;QFCGHQGNDMYDEE;QQQQQKAGEQQL 5 5.1 1.002 -0.69206 0 0 0 0 0 0 0 5.83557 9.49304 12.0933 7.48688 0 0 0 8.46891 A0A8I3NH69 A0A8I3NH69_CANLF Leucine rich repeat containing 66 LRRC66 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGTPRRGHPA;ENLWWLEK;LPSLKLLILRRN;QPCSDEPALWCER;SLSSDDAGNAEEEARESPEDE 5 6.6 1.0025 -1.0108 0 0 0 0 0 0 12.6934 7.04505 5.09951 0 0 0 0 8.49021 0 A0A8I3NH78 A0A8I3NH78_CANLF ADP ribosylation factor like GTPase 6 interacting protein 6 ARL6IP6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGGGGGD;GWGDAEGDEEDGCDP 2 10.1 0.98438 -0.25498 8.67634 8.71641 0 0 0 0 9.43871 9.59774 9.77707 0 0 0 0 0 0 A0A8I3NHD9 A0A8I3NHD9_CANLF Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) GGCX Canis lupus familiaris (Dog) (Canis familiaris) vitamin K metabolic process [GO:0042373] endoplasmic reticulum membrane [GO:0005789] gamma-glutamyl carboxylase activity [GO:0008488] EQLFLPYSHF;FIMLNRYNNCMDSDGK;GPSCYMYI;HLIKTNLFIMLNRYNNCMDSDGKH;KRSRAKGGQKPGLRHRLSA;LHSHLEGKAHD 6 9.2 1.0019 -1.3039 12.1447 0 10.2334 0 14.884 0 0 0 13.467 0 0 0 0 0 0 A0A8I3NHE1 A0A8I3NHE1_CANLF Ankyrin repeat domain 34A ANKRD34A Canis lupus familiaris (Dog) (Canis familiaris) EVIIITTDT;GAGGGGGG;GGGGGGGA;GGGGGGGG;PVELDTPGNMCPDS;SPGVEDPAPA;TEGPEDPP 7 12.2 1.003 -1.5905 0 0 0 0 6.75995 0 0 0 0 0 7.40922 0 0 0 7.11801 A0A8I3NHE4 A0A8I3NHE4_CANLF Calpain 11 CAPN11 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] NRKEDGEFWMSYQDFLGN;PTKNGKLVFV;WNGAWSDNASEWDK 3 5.9 1.0017 -0.74962 9.46215 0 0 0 0 0 0 0 0 0 0 0 9.78996 0 0 A0A8I3NHE7 A0A8I3NHE7_CANLF Peroxiredoxin-1 (EC 1.11.1.24) Canis lupus familiaris (Dog) (Canis familiaris) peroxiredoxin activity [GO:0051920] GASVDSHFSH 1 5 0.99971 -0.61146 7.92434 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NHE8 A0A8I3NHE8_CANLF Pre-mRNA processing factor 40 homolog A PRPF40A Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" FLSKKEKEQA;FMHVLEHECQHHHS;GMCSGSGR;KVQTEKEEKEEARSKYKEA;NRESFQIFLDE;SESKHKSP;SPDGRTYYYNTET;VGMCSGSGRRRSSLSPTM;VQTEKEEK;YPTISSDIRFTNML 10 11 0.99812 -3.3211 6.4622 0 8.95123 5.89726 8.14771 0 9.01187 0 0 0 7.69961 8.45224 2.6803 8.87 0 A0A8I3NHF6 A0A8I3NHF6_CANLF Pleckstrin homology domain-containing family O member 1 PLEKHO1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] EKTQELLAEVQGL 1 3.5 0.94094 0.059804 0 0 0 0 0 0 0 0 0 0 0 0 0 9.50231 0 A0A8I3NHG5 A0A8I3NHG5_CANLF Myb/SANT DNA binding domain containing 1 MSANTD1 Canis lupus familiaris (Dog) (Canis familiaris) EEIKIKIT;RNWTDAEMRGLMLVWEEFFDELK;VPESCDGKLPD 3 16.4 1.0024 -1.3558 0 0 0 0 0 0 0 0 0 0 6.85187 0 7.90153 0 7.67469 A0A8I3NHH4 A0A8I3NHH4_CANLF Exocyst complex component 1 like EXOC1L Canis lupus familiaris (Dog) (Canis familiaris) STYINDDSIWSSNN 1 8.1 0.93652 0.060902 0 0 0 0 0 0 0 0 0 8.51124 0 0 0 0 0 A0A8I3NHI2 A0A8I3NHI2_CANLF Mitochondria-eating protein (Spermatogenesis-associated protein 18) SPATA18 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial protein catabolic process [GO:0035694] mitochondrial outer membrane [GO:0005741] DYIICHLDLYDSQSSVNDVIRA;EQLERWRTEYSTNTCDQN;LDQRSIDKRNPDQ;VLSAEKSVLQGRS 4 13 0.98017 0.048313 0 0 0 0 0 0 0 0 0 0 9.02567 0 0 0 0 A0A8I3NHJ0 A0A8I3NHJ0_CANLF DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (C/EBP-homologous protein 10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153) DDIT3 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior axis specification [GO:0009948]; artery development [GO:0060840]; blood vessel maturation [GO:0001955]; cell redox homeostasis [GO:0045454]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; establishment of protein localization to mitochondrion [GO:0072655]; gene expression [GO:0010467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to nitrosative stress [GO:1990442]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell cycle [GO:0051726]; release of sequestered calcium ion into cytosol [GO:0051209]; response to platelet-derived growth factor [GO:0036119]; response to starvation [GO:0042594]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; vascular associated smooth muscle cell migration [GO:1904738]; vascular associated smooth muscle cell proliferation [GO:1990874]; Wnt signaling pathway [GO:0016055] CHOP-ATF3 complex [GO:1990622]; CHOP-ATF4 complex [GO:1990617]; CHOP-C/EBP complex [GO:0036488]; late endosome [GO:0005770]; protein-DNA complex [GO:0032993] "cAMP response element binding protein binding [GO:0008140]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; leucine zipper domain binding [GO:0043522]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator activator activity [GO:0140537]; transcription regulator inhibitor activity [GO:0140416]" QEIERLTREVEATRRAL 1 10.1 0.98342 0.046227 0 0 0 0 0 7.92434 0 0 0 0 0 0 0 0 0 A0A8I3NHK1 A0A8I3NHK1_CANLF Cadherin-5 (Vascular endothelial cadherin) CDH5 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; bicellular tight junction assembly [GO:0070830]; blood vessel endothelial cell migration [GO:0043534]; blood vessel maturation [GO:0001955]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell migration [GO:0030335]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein-containing complex assembly [GO:0031334]; protein localization to bicellular tight junction [GO:1902396]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein phosphorylation [GO:0001932]; regulation of vascular permeability [GO:0043114]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; external side of plasma membrane [GO:0009897]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] beta-catenin binding [GO:0008013]; BMP receptor binding [GO:0070700]; calcium ion binding [GO:0005509]; fibrinogen binding [GO:0070051]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; transmembrane transporter binding [GO:0044325]; vascular endothelial growth factor receptor 2 binding [GO:0043184] ARRGAPPP;ITLLVFLRRRLRRQ;KNLDRETQ;TVITLLVFLRRRLRRQ;VITLLVFLRRR;YPWYNLTVEA 6 5.4 1.001 -0.62954 0 0 5.36678 0 4.61888 8.96139 0 4.01105 0 0 0 0 11.1104 0 3.70543 A0A8I3NHK3 A0A8I3NHK3_CANLF Heat shock protein 90 alpha family class B member 1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] IVARTRKKKKTKKIK;IVETLWQKA;SQSGDEMTSLSEYV;VTKEGLELPEDEEEEKKM 4 11 0.98749 -0.22791 9.87007 0 0 0 0 0 0 0 6.1132 0 0 0 9.95881 0 12.7184 A0A8I3NHK4 A0A8I3NHK4_CANLF Transmembrane protein 63B TMEM63B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] calcium-activated cation channel activity [GO:0005227] PAKLDKKIH;TRLDLFFRWLF;TVYSMRRH 3 3.5 1.0022 -1.3935 0 0 0 0 8.6585 0 0 0 0 0 0 0 0 0 0 A0A8I3NHL5 A0A8I3NHL5_CANLF Cytoskeleton associated protein 2 like CKAP2L Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] CKPSSKGQQHKAVSST;EQDNHPSIKLQIA;LEPPKLLGRRL 3 5.9 0.98537 -0.23754 0 0 0 0 9.21747 0 0 0 0 0 5.44122 0 0 0 0 A0A8I3NHM2 A0A8I3NHM2_CANLF ADAM metallopeptidase domain 9 ADAM9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] GLSLGISYDDTK;GSQCDAGLCCTDCQ;LLYKLRNENTEDKQGIE;NQYMCYDGGCQDTDARCE;PVDVTIHNGRTCK;QYMCYDGGCQDTD;YMCYDGGC 7 9.7 1.003 -1.3333 10.2289 6.02614 0 8.94661 5.26164 0 0 0 0 0 0 0 0 0 10.2692 A0A8I3NHN0 A0A8I3NHN0_CANLF Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene c-ErbB-2) (p185erbB2) ERBB2 Canis lupus familiaris (Dog) (Canis familiaris) ERBB signaling pathway [GO:0038127]; negative regulation of apoptotic process [GO:0043066]; neuron differentiation [GO:0030182]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410] basal plasma membrane [GO:0009925]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] CWMIDSECRPRFRE;DPSPLQRYSE;EDDDMGDLVDAEEY;GAAGTQDN;GLLLALLPSG;GTVYKGIWIPDGEN;IAAVVGILLAVVVGLVLGILIKR;IDSECRPRFRE;IIAAVVGILLAVVVGLVLGILIK;KGMSYLEDVRLVHRDLAARN;LAVVVGLVLGILIKRRRQKI;LEDVRLVHRDLA;LLAVVVGLVLGILIKRRRQ;LVLGILIKRRRQKIR;LVLGILIKRRRQKIRK;RQKIRKYTMRRLLQ;SECRPRFRELVAEF;SIIAAVVGILLAVVVG;SIIAAVVGILLAVVVGLVLGILI;TDFGLARLLDIDETEYHADG;VGILLAVVVGLVLGILIK;VGILLAVVVGLVLGILIKRRR;VGLVLGILIKRRRQKI;VGLVLGILIKRRRQKIRKY;VGLVLGILIKRRRQKIRKYTMRR;VLGILIKRRRQKIRKYTMRRLLQ;VVGILLAVVVGLVLGILIK 27 15.7 1.004 -1.1044 11.651 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NHP0 A0A8I3NHP0_CANLF C-C motif chemokine receptor 2 CCR2 Canis lupus familiaris (Dog) (Canis familiaris) "blood vessel remodeling [GO:0001974]; cellular defense response [GO:0006968]; cellular homeostasis [GO:0019725]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; inflammatory response to wounding [GO:0090594]; leukocyte adhesion to vascular endothelial cell [GO:0061756]; macrophage migration [GO:1905517]; monocyte chemotaxis [GO:0002548]; monocyte extravasation [GO:0035696]; negative regulation of angiogenesis [GO:0016525]; negative regulation of eosinophil degranulation [GO:0043310]; negative regulation of type 2 immune response [GO:0002829]; neutrophil clearance [GO:0097350]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of astrocyte chemotaxis [GO:2000464]; positive regulation of CD8-positive, alpha-beta T cell extravasation [GO:2000451]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of immune complex clearance by monocytes and macrophages [GO:0090265]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of macrophage migration [GO:1905521]; regulation of T cell cytokine production [GO:0002724]; regulation of T cell differentiation [GO:0045580]; regulation of vascular endothelial growth factor production [GO:0010574]; sensory perception of pain [GO:0019233]; T-helper 17 cell chemotaxis [GO:0035705]" cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; fibrillar center [GO:0001650] C-C chemokine receptor activity [GO:0016493]; CCR2 chemokine receptor binding [GO:0031727]; chemokine (C-C motif) ligand 12 binding [GO:0035716]; chemokine (C-C motif) ligand 2 binding [GO:0035715]; chemokine (C-C motif) ligand 7 binding [GO:0035717] GEKFRRYLSLFFRRHIAKH 1 5.1 0.98481 -0.25339 0 0 0 0 0 0 13.5704 0 0 0 0 0 0 0 0 A0A8I3NHP6 A0A8I3NHP6_CANLF Olfactory receptor OR8B1N Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLGAMAHT;VGSIDIIMPCV 2 6 1.002 -1.2841 0 0 0 0 0 0 0 8.57433 0 0 0 0 9.68571 0 0 A0A8I3NHP7 A0A8I3NHP7_CANLF Sclerostin SOST Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; canonical Wnt signaling pathway [GO:0060070]; cellular response to parathyroid hormone stimulus [GO:0071374]; localization [GO:0051179]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of protein-containing complex assembly [GO:0031333]; ossification [GO:0001503]; positive regulation of DNA-templated transcription [GO:0045893]; response to mechanical stimulus [GO:0009612] extracellular space [GO:0005615] BMP binding [GO:0036122]; DNA-binding transcription factor binding [GO:0140297]; heparin binding [GO:0008201]; molecular function inhibitor activity [GO:0140678] PFETKDASEYSCR 1 6.1 0.94196 0.059729 0 0 0 0 0 0 0 0 0 0 5.64749 0 0 0 0 A0A8I3NHR8 A0A8I3NHR8_CANLF Ubiquinol-cytochrome c reductase complex assembly factor 6 UQCC6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743] KPGELKTELLGLKKR;LLSMCAGAEV 2 35.2 0.99432 -0.55758 0 7.6409 0 0 0 0 0 7.46213 0 0 0 0 0 0 0 A0A8I3NHS4 A0A8I3NHS4_CANLF TTL family tubulin polyglutamylase complex subunit L1 TTLL1 Canis lupus familiaris (Dog) (Canis familiaris) cerebellar Purkinje cell differentiation [GO:0021702]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; mucociliary clearance [GO:0120197]; protein modification process [GO:0036211]; regulation of blastocyst development [GO:0120222]; sperm axoneme assembly [GO:0007288] ciliary basal body [GO:0036064]; extracellular region [GO:0005576]; microtubule [GO:0005874] ATP binding [GO:0005524]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] EVLGNYEILNLKFWVLL;NKLSQIKKWSRDSKTSSF;SPLAEKDENGKYLYLDFV;VTYMLPADYNLFV 4 15.1 0.99712 -0.10822 0 0 7.95327 0 0 0 0 0 7.83061 0 0 0 0 9.04625 9.60166 A0A8I3NHT7 A0A8I3NHT7_CANLF Regulator of G protein signaling 6 RGS6 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; membrane [GO:0016020] GTPase activator activity [GO:0005096] EFLAPGAPSA;EPSQQRVKRWGFSFDE;FLSFFFFFFFFFFFFFFFFFFFFW;SSAGFLPSTFLLGFLFVCFFHLFFF 4 13.8 0.97402 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 8.05528 0 0 A0A8I3NHU1 A0A8I3NHU1_CANLF Cadherin related family member 2 CDHR2 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; catenin complex [GO:0016342]; microvillus membrane [GO:0031528] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AENGSQHGLVAELV;HFSLLPGPYSHNFSVGPDTGI;IGLGVALLLIIVIMTT;LDPQFIREFYS;LESGGAGG;NDQDSLTQLLQ;NLFTVDQSYRVRLQFSMNKEEVGAN;TINVEDIN;VTVQAQDRPS 9 9.5 1.0028 -2.5395 9.62416 0 0 8.15583 0 0 10.4415 0 12.656 0 0 8.97714 0 0 0 A0A8I3NHU5 A0A8I3NHU5_CANLF Desmocollin 1 DSC1 Canis lupus familiaris (Dog) (Canis familiaris) bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; cellular response to starvation [GO:0009267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911] adherens junction [GO:0005912]; cytoplasmic vesicle [GO:0031410]; desmosome [GO:0030057]; endoplasmic reticulum [GO:0005783]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLQIVVVNEAPY;EENTVDVEILRVTVEDKDLMNTAN;EWVRINENTGSI;GCCSERQE;GVITTSSS;INGPPFDFRLENIPDSDIERTWRLT;LQHQTKKRHSKEKVLRRAKRRWAPI;SLGPFPLFLQQIQ;SYVTSVEEN;VLRRAKRR;WHNFTQPRLGEKVQLCNQDDKH 11 17.2 0.97692 0.035538 0 0 0 0 0 0 0 0 6.60609 0 0 0 0 0 0 A0A8I3NHV0 A0A8I3NHV0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GEGASRNSFPRQQRGRAGTRG 1 4.1 0.98503 -0.24044 0 0 0 0 9.98982 0 0 0 0 0 0 0 0 0 0 A0A8I3NHW0 A0A8I3NHW0_CANLF Eyes absent homolog (EC 3.1.3.48) EYA3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] KYGKDPTVVIGSGLTMEEMIF;LGEIFPIENIYSATKIG 2 9.1 0.99051 -0.14713 7.53349 7.21121 0 0 0 7.55674 8.2538 0 8.02995 0 0 7.79025 9.03631 0 0 A0A8I3NHW7 A0A8I3NHW7_CANLF Olfactory receptor OR4P4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALFIYLRPAT 1 3.2 0.99964 -0.61146 0 0 0 0 0 7.54767 0 8.03282 0 0 0 0 0 0 0 A0A8I3NHW9 A0A8I3NHW9_CANLF WD and tetratricopeptide repeats 1 WDTC1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fatty acid biosynthetic process [GO:0045717] Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737] ALFSKNDGEEKKGAGGG;GAGGGGGG;KGAGGGGG;RKCHSSGEVQNGKMS;TNGVSNGV 5 6.9 0.99449 -0.56235 8.31329 0 0 0 0 0 0 0 0 0 12.376 0 0 10.5308 0 A0A8I3NHX4 A0A8I3NHX4_CANLF Uncharacterized protein LOC119881386 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] CIGDSNPPASVSWTRGS;GVAFTSWGSKTPHSSVL;NPLRKVQEGTQDRFCLLG;QDAPVATNNPLRKVQEGTQDR;SQLPPSLHWQLGE;VERGSYVR 6 14.2 1.0023 -1.1744 7.1812 8.7046 0 0 0 0 4.80617 10.7873 0 0 0 5.64472 0 0 0 A0A8I3NHX5 A0A8I3NHX5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GPKAGAKP;LPDNKFKNT 2 16.3 0.98979 -0.19655 0 8.9344 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NHX7 A0A8I3NHX7_CANLF Calcipressin-2 (Regulator of calcineurin 2) RCAN2 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722] cytoplasm [GO:0005737]; nucleus [GO:0005634] calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676] DVSTLVACVVDV;GPGEKYELH;VSTLVACVVDVEVFTNQ 3 13.7 0.98835 -0.47605 4.72367 0 0 0 0 10.4574 0 0 0 0 0 0 4.83709 4.9771 0 A0A8I3NHX9 A0A8I3NHX9_CANLF Cadherin 3 CDH3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EPRWITICNQSPVPQMLNI;EVNEKVLLLVLLLLVR;GRARAASGQSAPTCAHLAP;KREWVVPPISV;KVLLLVLLLLVRRKRKVK;LLLVLLLLVRRKRK;LLLVLLLLVRRKRKVK;LLLVLLLLVRRKRKVKE;LLLVRRKRKVKEPLL;LLVLLLLVRRKRKVK;LLVLLLLVRRKRKVKE;LVLLLLVRRKRKVKEPLLLPED;LVRRKRKVK;VLLLLVRRKRK;VLLLLVRRKRKVK;VLLLLVRRKRKVKEPLLLP;VLLLVLLLLVR;VLLLVLLLLVRRKRK;VLLLVLLLLVRRKRKVK;VLLLVLLLLVRRKRKVKE;YWTAEVNEKVLLLVLLLLVRRKRK 21 8.6 0.65984 0.32275 6.41566 4.64108 6.15805 0 0 8.12231 4.29028 4.42673 3.63471 4.19669 0 7.36772 6.20569 6.82858 5.39886 A0A8I3NHY0 A0A8I3NHY0_CANLF Thyrotropin-releasing hormone receptor (Thyroliberin receptor) TRHR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] thyrotropin-releasing hormone receptor activity [GO:0004997] QTVSELNQTQ 1 2.5 0.99892 -0.61146 0 0 0 0 0 0 0 9.2057 0 0 0 0 0 0 0 A0A8I3NHY4 A0A8I3NHY4_CANLF Mitochondrial transcription termination factor 2 MTERF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] mitochondrial nucleoid [GO:0042645] double-stranded DNA binding [GO:0003690] ENKRTVEKLYKFSVDIRKIRRLK;NVVIGRFLTTAS 2 9.1 0.98973 -0.26605 0 0 0 0 0 0 0 0 0 0 0 5.92084 0 0 0 A0A8I3NHY5 A0A8I3NHY5_CANLF Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) CPD Canis lupus familiaris (Dog) (Canis familiaris) peptide metabolic process [GO:0006518]; protein processing [GO:0016485] extracellular space [GO:0005615]; membrane [GO:0016020] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] CKNMYPNEYFPHGITNG;FDLNRNFPDQFF;HHDEYEDE;ISNKPNISEPEEP;LFLLLLLLLLLQ;LLLLLLLL;LLLLLLLLL;LSHEFQDETDTEE;PFQQPIQPKDFHHHH;TYGHCPEITVY;VLTGYMPLT;VTGSGLENATIS;VVGRELLLNLIEYLCKNFGT 13 10.3 0.94952 0.05044 0 0 0 0 0 4.49934 0 0 0 0 0 0 0 0 0 A0A8I3NHZ0 A0A8I3NHZ0_CANLF Cytosolic iron-sulfur assembly component 2B CIAO2B Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654] MATLIGLSIKVKLLR 1 9.1 0.9509 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 3.77957 0 0 A0A8I3NHZ2 A0A8I3NHZ2_CANLF ADP ribosylation factor like GTPase 1 ARL1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] GTP binding [GO:0005525]; GTPase activity [GO:0003924] ETVTYKNLKFQ 1 8.1 0.98121 0.035491 10.0464 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NHZ6 A0A8I3NHZ6_CANLF Regulatory factor X4 RFX4 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; regulation of protein processing [GO:0070613]; telencephalon development [GO:0021537] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ELIQAPERAPVE;ENEEKENNRAS;EWLDTMVDRCVV;GNSSDMYTP;IQLYQEFDHLLE;PTPVTPRWPE;TEAAPPTP;TPLTTRRNS 8 10.8 1.0029 -2.1664 11.2204 14.5495 0 9.96233 0 0 8.10821 9.56695 0 0 9.33215 0 4.01855 7.60503 0 A0A8I3NHZ8 A0A8I3NHZ8_CANLF Acid sensing ion channel subunit 2 ASIC2 Canis lupus familiaris (Dog) (Canis familiaris) detection of mechanical stimulus involved in sensory perception [GO:0050974]; establishment of localization in cell [GO:0051649]; negative regulation of apoptotic process [GO:0043066]; phototransduction [GO:0007602]; positive regulation of synapse assembly [GO:0051965]; protein localization to synapse [GO:0035418]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [GO:0003026]; regulation of vasoconstriction [GO:0019229]; response to acidic pH [GO:0010447]; sensory perception of sound [GO:0007605]; sensory perception of sour taste [GO:0050915]; synapse assembly [GO:0007416] dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280]; monoatomic ion-gated channel activity [GO:0022839] AKLHGLRHMCAGRAAAGGSFQR;APFCTPEQHKECAEPALGLLAEK;LGKEEDEGSHDE;LVSELLRGDEPRRQWF;QTFVATQE 5 14.3 0.99238 -0.19401 0 9.24215 0 10.6235 0 7.16531 0 0 7.64875 0 0 7.22593 0 0 0 A0A8I3NI00 A0A8I3NI00_CANLF AlkB homolog 7 ALKBH7 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445] mitochondrial matrix [GO:0005759] ILRGSARYD 1 4.1 1.0035 -0.80421 10.2851 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NI03 A0A8I3NI03_CANLF "RAP1B, member of RAS oncogene family" RAP1B Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; Rap protein signal transduction [GO:0032486] cytosol [GO:0005829]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] NEIFYDLVRQINRKTPV 1 12.4 0.97678 0.046227 0 0 0 0 9.06315 0 0 0 0 0 0 0 0 0 0 A0A8I3NI06 A0A8I3NI06_CANLF Enkurin domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) DLDLDATPPRGPRMNPG;NPFVKIKPFVHSEKKKKKKRTR 2 15.8 0.93654 0.092926 0 0 0 0 0 0 8.90147 0 0 0 0 0 0 0 9.09727 A0A8I3NI08 A0A8I3NI08_CANLF Growth factor receptor bound protein 7 GRB7 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DLIQNFLNAGSFPE;EDLYLAPGTP;GAQLYKNYQ;NHRLSLPTPGSG 4 10.1 0.99892 -0.61146 0 0 0 0 0 9.73044 0 0 0 0 0 0 0 0 0 A0A8I3NI30 A0A8I3NI30_CANLF Clathrin light chain CLTA Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; synaptic vesicle membrane [GO:0030672] clathrin heavy chain binding [GO:0032050]; structural molecule activity [GO:0005198] AGIENDEAF;GVPDANSRKQEAEWKEKA;PASAPGGP 3 21.1 1.0023 -1.8603 0 0 0 0 8.0691 0 9.82952 0 9.99407 0 0 0 0 0 4.46022 A0A8I3NI31 A0A8I3NI31_CANLF F-box protein 7 FBXO7 Canis lupus familiaris (Dog) (Canis familiaris) lymphocyte differentiation [GO:0030098]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; positive regulation of mitophagy [GO:1901526]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein targeting to mitochondrion [GO:0006626]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647] classical Lewy body [GO:0097414]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005] protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DLICLILEDAI;GQAAQTDVWNEDNMSGP;QAAQTDVWN;SPWHPRPFPPSSLLPPG 4 8.6 1.0028 -0.86137 0 0 0 0 0 0 0 11.408 9.15284 0 0 0 11.2277 0 0 A0A8I3NI45 A0A8I3NI45_CANLF Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) FASLG Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; immune response [GO:0006955]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of phosphatidylserine exposure on apoptotic cell surface [GO:1905782]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; retinal cell programmed cell death [GO:0046666]; T cell apoptotic process [GO:0070231] cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634] cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164] DLMLMEGKIMNY;GSVLPCPSSVPGRPGQR;LAELRESTSERHVA;SVLPCPSSVPG 4 15.1 1.0004 -0.61976 8.35698 8.17438 0 0 0 8.89521 0 6.17979 0 0 0 0 0 0 0 A0A8I3NI47 A0A8I3NI47_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) CTH Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] membrane [GO:0016020] pyridoxal phosphate binding [GO:0030170] GLLLLLLLLLLLPLLLPLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLP;LLLLLLLLLLPLLLLL;LLLLLLLLLPLLLLL;LLLLLLLLP;LLLLLLLP;LLLLLLLPLLLPLLLL;LLLLLLPL;LLLLLLPLLLTLLL;LLLLLPLL;LLLLLPLLLTLLLPLLLLLP;LLLLLPLLLTLPLPLPLPLPA;LLLLPLLLLLLLPLLLT;LLLLTLLLLLLLLLLL;LLLPLLLLL;LLLPLLLLLL;LLLPLLLLLPLLLLLP;LLLPLLLLLPLLLLLPL;LLLPLLLLLPLLLLLPLL;LLPLLLLLPLLLLLPLLL;LPLLLLLPLLLLLPLLL;LPLLLLLTLLLLLLLLLLL;PGGRRPRGLLLLLLLLLLL;PLLLLLLLPLLLTLLL;PLLLLLPLLLLLPLLLTL;PLLLLLPLLLLLPLLLTLPL;PLLLLLTLLLLLLL;PLLLLLTLLLLLLLL;PLLLLLTLLLLLLLLL;PLLLLLTLLLLLLLLLL;PLLLLLTLLLLLLLLLLLPLL;PLLLPLLLLLTLLLLLLLLLL;PLLLTLLLPLLLL;PLLLTLLLPLLLLLPLL;PLLLTLLLPLLLLLPLLLLL;RGLLLLLL;RRPRGLLLLLLLLLLL;TLLLLLLL;TLLLLLLLLLLL;TLLLLLLLLLLLP;TLLLLLLLLLLLPLLLL;TLLLLLLLLLLLPLLLLLL;TLLLLLLLLLLLPLLLLLLL;TLLLPLLLLLPLLLLLP;TLLLPLLLLLPLLLLLPL;TLLLPLLLLLPLLLLLPLLL;TLLLPLLLLLPLLLLLPLLLTLP 51 14.4 1.002 -1.2039 9.11434 10.6457 7.87135 8.32247 7.37764 11.6685 7.62994 10.0765 9.33013 5.3331 9.26242 9.20249 9.84847 11.0445 8.85534 A0A8I3NI52 A0A8I3NI52_CANLF Mitochondrial ribosomal protein L2 MRPL2 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] organelle membrane [GO:0031090]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] TENMQAGDIILNSDHIGRMAV 1 9.3 0.94881 0.049996 7.38241 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NI61 A0A8I3NI61_CANLF Dual specificity phosphatase 14 DUSP14 Canis lupus familiaris (Dog) (Canis familiaris) MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] LVHCAAGV;VIRPNVGFWRQLIDYE 2 12.1 1.0038 -1.0552 0 0 0 0 0 10.5845 10.8203 0 0 0 0 0 0 0 0 A0A8I3NI65 A0A8I3NI65_CANLF A-kinase anchor protein 2 C-terminal domain-containing protein PALM2AKAP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] plasma membrane [GO:0005886] AEPSPGQDGTSRAAGVGWET;EDNIQRLEQE;GGGGGGGG;SEEDEFRVKQL;VLDNDVAREIRYLD 5 5.1 0.94905 0.049568 0 0 0 0 0 0 0 0 0 0 8.55984 0 0 0 0 A0A8I3NI67 A0A8I3NI67_CANLF Multiple C2 and transmembrane domain containing 1 MCTP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DMLEDEEEEDDKDDK;DVPLADPG;EEKACILVEHLRE;IPLRYIVLVWGI;VDLSENEVVGSYFSVKSFFWRFQT 5 9.8 0.97423 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 6.12557 0 0 A0A8I3NI73 A0A8I3NI73_CANLF DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) POLR3C Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] RNA polymerase III complex [GO:0005666] single-stranded DNA binding [GO:0003697] LVIYQVHKRGVVEYEAQCSRVL 1 5.4 0.98496 -0.25787 0 0 0 0 0 0 0 0 0 0 0 0 12.4137 0 0 A0A8I3NI74 A0A8I3NI74_CANLF Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) CTH Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process [GO:0019344]; transsulfuration [GO:0019346] pyridoxal phosphate binding [GO:0030170] CSCSCSCSCSRSC;CSCSCSCSCSRSCSC;GGPAGSCSCSCSCSC;GSCSCSCSCSCS;GSCSCSCSCSCSRSCSRSCSCS;PAGSCSCSCSCSC;SCSCSCSCSC;SCSCSCSCSCS;SCSCSCSCSCSRSCSCSCS 9 8.2 0.926 0.096109 6.60245 0 0 0 5.12172 0 0 0 0 0 0 0 0 0 0 A0A8I3NI80 A0A8I3NI80_CANLF Ankyrin repeat domain 13B ANKRD13B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of receptor internalization [GO:0002091] early endosome [GO:0005769]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] ubiquitin-modified protein reader activity [GO:0140036] LLAHGADV;LSEQHKGKVKGC 2 3.2 1.0042 -1.0539 0 0 0 7.57992 0 8.86774 0 5.60769 0 0 0 0 0 0 0 A0A8I3NI83 A0A8I3NI83_CANLF Ataxin-10 ATXN10 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cilium assembly [GO:0060271]; neuron projection development [GO:0031175] cytosol [GO:0005829]; dendrite [GO:0030425]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] IECSVNQNSIRNLDTIG;PESEWPFLI;QVEHLASSLQLITEC;VNELDGIPLILDSCSID 4 12.2 0.99075 -0.53738 5.47651 0 0 0 0 0 9.59533 0 0 9.02309 0 0 10.8379 0 0 A0A8I3NI94 A0A8I3NI94_CANLF Leukocyte specific transcript 1 LST1 Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; immune response [GO:0006955] membrane [GO:0016020] CEKWREVRRLERSWAQLSEQELHY;EVRRLERSWAQ 2 37.5 0.98519 -0.25801 0 0 0 0 0 9.28674 7.46809 0 0 0 0 0 0 0 0 A0A8I3NI98 A0A8I3NI98_CANLF Protein geranylgeranyltransferase type I subunit beta PGGT1B Canis lupus familiaris (Dog) (Canis familiaris) CAAX-protein geranylgeranyltransferase complex [GO:0005953] CAAX-protein geranylgeranyltransferase activity [GO:0004662] PALNVSTRTS 1 3.3 0.98801 -0.26075 0 0 0 0 0 9.82652 0 0 0 0 0 0 0 0 0 A0A8I3NIA5 A0A8I3NIA5_CANLF Ameloblastin AMBN Canis lupus familiaris (Dog) (Canis familiaris) odontogenesis of dentin-containing tooth [GO:0042475] extracellular region [GO:0005576] structural constituent of tooth enamel [GO:0030345] HPPPLPSQPS;IFYMSYGAN;PSPLYPGIFY;TDTTVIPDTQQTLMPE 4 10 1.0031 -1.9161 0 0 0 0 0 0 0 10.4582 0 0 0 9.03999 5.17883 0 0 A0A8I3NIB6 A0A8I3NIB6_CANLF Solute carrier family 12 member 4 LCAT Canis lupus familiaris (Dog) (Canis familiaris) cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573] plasma membrane [GO:0005886]; synapse [GO:0045202] potassium:chloride symporter activity [GO:0015379] RMRIFTVAQMDDNSIQ;VLGWPYGWRQSEDPRAWKTFIDTVR 2 3.9 0.69256 0.27016 0 10.3441 0 10.8274 0 11.4048 0 0 0 0 0 0 0 0 0 A0A8I3NIB8 A0A8I3NIB8_CANLF CTTNBP2 N-terminal like CTTNBP2NL Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transmembrane transport [GO:0034763] actin cytoskeleton [GO:0015629] protein phosphatase 2A binding [GO:0051721] KNMQERMLSQLAAAE;KQCKNMQERMLSQL;NGHFEPETQ;QRDFEILKEKNDGE;TLKEEMESLKKIMKDLEASQQHSGP 5 10.3 1.0029 -0.86513 10.8035 7.82579 0 5.63067 9.89551 0 10.4189 0 5.14356 0 0 0 0 0 0 A0A8I3NIC5 A0A8I3NIC5_CANLF Glycosyltransferase 8 domain containing 2 GLT8D2 Canis lupus familiaris (Dog) (Canis familiaris) UDP-glycosyltransferase activity [GO:0008194] DFPSVHNDL;ELLQPLNFVRFYLP;ELYDTTLALGH;SAINPLWH;VICAAAGRMGAAMAAIN 5 16.9 1.0028 -1.5072 0 8.35623 0 7.95111 0 9.65862 0 0 0 0 0 0 0 13.241 8.73505 A0A8I3NIE7 A0A8I3NIE7_CANLF Integrin subunit alpha D ITGAD Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] metal ion binding [GO:0046872] LTQIPGSLVLNCSIAD;PLEVVAVNQTGRLYDCVA 2 2.9 0.94098 0.10122 5.74166 0 0 0 0 0 0 0 0 0 0 0 0 8.03463 0 A0A8I3NIF2 A0A8I3NIF2_CANLF Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) NRM Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637] VGQHSLMATEI 1 5.4 0.9903 -0.26726 0 0 0 0 0 0 0 0 0 0 0 0 0 9.38243 0 A0A8I3NIF4 A0A8I3NIF4_CANLF Family with sequence similarity 83 member B FAM83B Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742] cytoplasm [GO:0005737]; membrane [GO:0016020] epidermal growth factor receptor binding [GO:0005154]; phosphatidylinositol 3-kinase catalytic subunit binding [GO:0036313]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein kinase binding [GO:0019901] KAPAFYRM;MHNVTQSIEEDR;NLDLGWPYVMPG 3 3.2 1.0029 -1.3399 0 0 0 6.6476 0 0 0 9.11533 0 6.79559 0 0 0 0 0 A0A8I3NIF7 A0A8I3NIF7_CANLF Allograft inflammatory factor 1 AIF1 Canis lupus familiaris (Dog) (Canis familiaris) "actin crosslink formation [GO:0051764]; actin filament polymerization [GO:0030041]; cellular response to oxidative stress [GO:0034599]; cellular response to type II interferon [GO:0071346]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell proliferation [GO:0048662]; parallel actin filament bundle assembly [GO:0030046]; phagocytosis, engulfment [GO:0006911]; positive regulation of chemokine production [GO:0032722]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; Rac protein signal transduction [GO:0016601]; ruffle assembly [GO:0097178]" actin filament [GO:0005884]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] KAQQEDRLD 1 6.1 1.0036 -0.80421 0 0 0 0 0 0 0 8.43696 0 0 0 0 0 0 0 A0A8I3NIG4 A0A8I3NIG4_CANLF Ovochymase 2 OVCH2 Canis lupus familiaris (Dog) (Canis familiaris) fertilization [GO:0009566]; proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] KVLPWIHKHIQIGKRRK;SLHYPEDYSDMANC 2 5.5 0.93207 0.107 0 0 0 0 3.94167 0 0 8.8875 0 0 0 0 0 0 0 A0A8I3NIG5 A0A8I3NIG5_CANLF dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) TMTC2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] SHPIHTEAV 1 1.4 1.0037 -0.80421 0 0 0 0 0 0 0 0 0 8.27193 0 0 0 0 0 A0A8I3NIH3 A0A8I3NIH3_CANLF Exostosin glycosyltransferase 1 EXT1 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation [GO:0019882]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; bone resorption [GO:0045453]; canonical Wnt signaling pathway [GO:0060070]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell adhesion mediated by integrin [GO:0033627]; cell fate commitment [GO:0045165]; cellular response to virus [GO:0098586]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate metabolic process [GO:0030204]; collagen fibril organization [GO:0030199]; cranial skeletal system development [GO:1904888]; dendrite self-avoidance [GO:0070593]; dendritic cell migration [GO:0036336]; developmental growth involved in morphogenesis [GO:0060560]; embryonic skeletal joint development [GO:0072498]; endochondral bone growth [GO:0003416]; endochondral ossification [GO:0001958]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fear response [GO:0042596]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fluid transport [GO:0042044]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glomerular basement membrane development [GO:0032836]; hair follicle morphogenesis [GO:0031069]; heart contraction [GO:0060047]; heart field specification [GO:0003128]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]; hematopoietic stem cell migration to bone marrow [GO:0097241]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; hypersensitivity [GO:0002524]; leukocyte tethering or rolling [GO:0050901]; limb joint morphogenesis [GO:0036022]; lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339]; lymphocyte migration into lymphoid organs [GO:0097021]; mesenchymal cell differentiation involved in bone development [GO:1901706]; mesoderm development [GO:0007498]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; multicellular organismal-level water homeostasis [GO:0050891]; neural crest cell differentiation [GO:0014033]; olfactory bulb development [GO:0021772]; optic nerve development [GO:0021554]; ossification involved in bone maturation [GO:0043931]; perichondral bone morphogenesis [GO:0061974]; podocyte differentiation [GO:0072112]; protein catabolic process [GO:0030163]; protein glycosylation [GO:0006486]; protein-containing complex assembly [GO:0065003]; regulation of blood pressure [GO:0008217]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to heparin [GO:0071503]; response to leukemia inhibitory factor [GO:1990823]; response to light intensity [GO:0009642]; sebaceous gland development [GO:0048733]; smoothened signaling pathway involved in lung development [GO:0060506]; social behavior [GO:0035176]; sodium ion homeostasis [GO:0055078]; stem cell division [GO:0017145]; stomach development [GO:0062094]; sulfation [GO:0051923]; sweat gland development [GO:0060792]; synaptic transmission, glutamatergic [GO:0035249]; tight junction organization [GO:0120193]; vacuole organization [GO:0007033]; vasodilation [GO:0042311]; vocalization behavior [GO:0071625]; wound healing [GO:0042060]" catalytic complex [GO:1902494]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; synapse [GO:0045202] glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] VLSTTEVDFAFT;VMLSNGWELPFSEVINWN 2 4.3 0.93277 0.098753 0 0 0 0 0 0 10.1743 0 0 0 0 0 0 0 6.26562 A0A8I3NIH8 A0A8I3NIH8_CANLF "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" TDO2 Canis lupus familiaris (Dog) (Canis familiaris) protein homotetramerization [GO:0051289]; tryptophan catabolic process to kynurenine [GO:0019441] "heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; tryptophan 2,3-dioxygenase activity [GO:0004833]" EAWLERTPGLEP;EYCDSSYF;ILKLLVQQFSVLETMTAL;LVEAWLERTPGLEPHGF 4 10.6 1.0023 -1.3231 0 0 0 6.39722 0 0 8.18987 0 0 7.1532 0 0 0 0 0 A0A8I3NII2 A0A8I3NII2_CANLF Exocyst complex component 1 EXOC1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] exocyst [GO:0000145] ASSRGIEACTNAADA;EAKQKYTDHLQSYVI;FDKIFEQV 3 4.5 1.0019 -0.67744 11.8358 0 0 0 0 0 0 0 11.9036 0 0 0 11.1062 0 0 A0A8I3NII4 A0A8I3NII4_CANLF PBX/knotted 1 homeobox 2 PKNOX2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] DEDEMEEEEEEELEEETDEL;DEDEMEEEEEEELEEETDELQTTNV;EDEMEEEEEEELEEETDEL;GVSNNPQGIVV;LDGTEEEDEDEME;LDGTEEEDEDEMEEEEEEEL;SLDGTEEEDEDEME 7 9.3 0.98801 -0.34757 0 0 0 7.7213 6.95919 4.3385 6.88716 0 0 0 0 0 8.17333 0 0 A0A8I3NIJ4 A0A8I3NIJ4_CANLF Fatty acid desaturase 2 FADS2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] oxidoreductase activity [GO:0016491] LGEWQPIE;NFQIEHHLFP;VLGEWQPIEYGKK;VNMLHVFVLGEW;YTFRSITSH 5 9.4 0.98378 -0.25453 0 0 0 0 0 0 0 0 0 0 8.92591 0 0 0 0 A0A8I3NIJ9 A0A8I3NIJ9_CANLF Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) VSX2 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EMLAMKTELPEDRIQ;LAPGHLLA;SDRKMSKSALNQTKKR 3 10.8 1.0026 -1.3992 0 0 0 0 0 0 0 9.11426 0 0 7.88521 0 0 0 0 A0A8I3NIK0 A0A8I3NIK0_CANLF Ring finger protein 4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein localization to chromatin [GO:0120186]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]; response to arsenic-containing substance [GO:0046685] cytoplasm [GO:0005737]; microtubule end [GO:1990752]; PML body [GO:0016605] identical protein binding [GO:0042802]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] KKINHKRYHPIY 1 6.3 0.95298 0.05044 8.3271 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NIL6 A0A8I3NIL6_CANLF Olfactory receptor family 10 subfamily AI member 1 OR10AI1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VKGALKKL 1 2.6 1.0034 -1.1044 3.33557 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NIM4 A0A8I3NIM4_CANLF Pleckstrin homology domain containing A2 PLEKHA2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]" CEQDREPL;DSLLMSRLGE;SISLTRSGSSSHSG;SLGMPYVDRQN 4 9.6 1.0033 -1.5809 0 10.4361 0 9.03617 0 8.50096 0 0 0 0 0 0 0 0 0 A0A8I3NIM5 A0A8I3NIM5_CANLF Claspin CLSPN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DDASQMDLFHRDSDDDQMEE;DIDEYEQDEIDEVLPSDE;DLFETGLEEEETNSALEDEESL;EEEGNQENAEFLLSG;EIETKEEKEMDKDNSDGSS;EKDGEEEEDGDLEEEKEEE;EKIRRLKKKETKSE;ETNSALEDE;GLKKTEEADDKVEEPRQ;KKLKSKKVLQ;LEEEEEEEGNQE;LKSKKVLQ;LVAPEPHSLERE;NEDGFEEEEEEEEEMTDDSE;NIDDASQMDLFHRDSDDDQ;NSPSDSGQGSCE;PCLERSLQ;VSGSDVGSEDEYD 18 17.6 0.99894 -3.1471 12.7228 6.75822 9.8525 0 10.1623 4.56212 0 0 8.63626 7.48736 9.552 6.65234 6.90689 0 0 A0A8I3NIN2 A0A8I3NIN2_CANLF Ras like without CAAX 1 RIT1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DTPVVLVG;YSITDRRSFHEVREFKQL 2 11.9 1.0027 -1.3787 0 6.40426 0 0 0 0 0 0 0 0 0 0 7.8666 0 0 A0A8I3NIN8 A0A8I3NIN8_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" SMARCE1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] SWI/SNF complex [GO:0016514] nuclear receptor binding [GO:0016922]; nucleosomal DNA binding [GO:0031492] EESRQRQSRMEKG;SRAEAALEEESRQRQSRMEKGEP 2 8.3 0.97596 0.04644 0 0 8.79438 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NIP4 A0A8I3NIP4_CANLF Ring finger protein 4 Canis lupus familiaris (Dog) (Canis familiaris) EWFSLFHWVWIQK 1 14.9 0.99043 -0.27395 0 0 0 0 0 0 0 0 0 0 0 0 9.41475 0 0 A0A8I3NIQ5 A0A8I3NIQ5_CANLF Protein cereblon CRBN Canis lupus familiaris (Dog) (Canis familiaris) locomotory exploration behavior [GO:0035641]; positive regulation of Wnt signaling pathway [GO:0030177]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] WPRWLYSLYDAETLM 1 3.4 0.98371 -0.24378 0 0 0 0 0 8.74625 0 0 0 0 0 0 0 0 0 A0A8I3NIR2 A0A8I3NIR2_CANLF G protein pathway suppressor 1 GPS1 Canis lupus familiaris (Dog) (Canis familiaris) protein deneddylation [GO:0000338] COP9 signalosome [GO:0008180]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] PGGREVWAMGPGPGPPR;TTVAALEDELTQ;VGAGAGAG 3 5.5 0.99261 -0.13953 0 0 0 8.47163 0 9.6162 0 0 0 0 0 0 0 0 0 A0A8I3NIR5 A0A8I3NIR5_CANLF Transporter SLC6A20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] IAVCYVYGLR;LVFTMEAG;VLAWLVVYL;VTKDYPPHALA;WKVIWAGVSPLLIV;YRKTLNISPSIQDSGR 6 12.2 0.99923 -3.0612 0 11.3783 0 0 0 8.51321 0 8.45594 5.97366 0 0 0 0 0 0 A0A8I3NIS2 A0A8I3NIS2_CANLF DNA polymerase delta interacting protein 3 POLDIP3 Canis lupus familiaris (Dog) (Canis familiaris) poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727] cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607] mRNA binding [GO:0003729]; protein-containing complex binding [GO:0044877] VNNHPAKQNLYDLEED 1 3.8 0.95612 0.049233 0 0 0 0 0 0 0 0 0 0 5.15324 0 0 0 0 A0A8I3NIT0 A0A8I3NIT0_CANLF Solute carrier family 45 member 4 SLC45A4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMFANVYVAMIMISTMGIVSMSIS;GVALFPEEVQS;LVVMRMAPQNA;SSTFSYYG;YDLQKRQRQRCRHRNQSG;YYSLTWFLS 6 11.3 1.0029 -1.5261 9.42164 0 0 0 0 8.22342 9.42631 0 0 0 8.55854 0 0 0 0 A0A8I3NIU1 A0A8I3NIU1_CANLF RING finger protein 141 RNF141 Canis lupus familiaris (Dog) (Canis familiaris) protein autoubiquitination [GO:0051865]; regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] DPDENSSSV;KQLTDEEECCICM;LILPCAHSFC;VLAQSAWGSF 4 14.6 1.0018 -1.2073 0 9.72385 0 0 0 0 0 0 0 0 0 0 9.93629 0 8.31569 A0A8I3NIV6 A0A8I3NIV6_CANLF Uncharacterized protein ZNF207 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] CWYCNRDFDDE;DEYDDDDSAASTSF;DISLEERRAQ;LMPGMPPVMPGMPPGLH;PATTTEPPKPTFPAYTQS;QQDDSDEYDDDD 6 16.2 0.98744 -0.35336 8.12205 9.09556 0 0 7.6953 7.20281 10.166 9.62972 10.3618 0 0 0 8.93826 0 4.61965 A0A8I3NIW1 A0A8I3NIW1_CANLF Mitochondrial poly(A) polymerase MTPAP Canis lupus familiaris (Dog) (Canis familiaris) histone mRNA catabolic process [GO:0071044]; mitochondrial RNA 3'-end processing [GO:0000965] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; poly(A) RNA polymerase activity [GO:1990817]; protein homodimerization activity [GO:0042803]; UTP binding [GO:0002134] IPGSWITNFSL;NKPESSPLHIQNPFETSLNISKNV;SQTSEQSCIQCSNHS;SVTSLQNITRTPSMD;WITNFSLTMMVIFFL 5 12.5 0.98725 -0.37858 7.51901 0 0 0 10.339 0 7.75422 0 5.5493 0 0 0 0 10.3454 0 A0A8I3NIX3 A0A8I3NIX3_CANLF NLR family member X1 NLRX1 Canis lupus familiaris (Dog) (Canis familiaris) ALSQLFDPDACGRR;GIVAKLLPLRALPLLLNLLK;GIVAKLLPLRALPLLLNLLKVV;IVAKLLPLRALPLLLNLLKV;KLLPLRALPLLLNLLK;LEAWRRVWSRSLQLATWPN;LGIVAKLLPLRALPLLL;PLMAAAGS;PRSEAEEEEEV;SLVLGIVAKLLPLRALPLLL;VGRYGEIC;VLDWCYGRLPAFELLIP;VLGIVAKLLPLRALPLLLNLLK 13 10.7 0.98198 -0.24927 0 0 0 0 0 0 7.97137 0 0 0 0 0 0 0 0 A0A8I3NIX8 A0A8I3NIX8_CANLF Olfactory receptor OR8D2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IMAVGIFFGSITFMYFKPPSSNT 1 7.8 0.97909 0.046276 0 0 0 0 0 6.79948 0 0 0 0 0 0 0 0 0 A0A8I3NIX9 A0A8I3NIX9_CANLF RHO family interacting cell polarization regulator 1 RIPOR1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GVLGSHERGP;LEVTWSPFDKDD;LSTTGPAHT;SELEAQLGE;SPLAPMPQHLDLSPD;SPRPRRPPGPAGPAPSRLAES 6 5.4 1.0017 -1.2516 9.77307 0 0 11.1171 11.5932 0 11.4988 0 11.881 0 0 0 8.30779 9.81207 0 A0A8I3NIY2 A0A8I3NIY2_CANLF Arrestin domain containing 5 ARRDC5 Canis lupus familiaris (Dog) (Canis familiaris) CLPSWPLETPSQN;SYLTPEQQ 2 5 0.98973 -0.19866 0 0 0 0 0 0 0 0 0 9.10497 7.18468 0 0 7.24174 0 A0A8I3NIZ4 A0A8I3NIZ4_CANLF Placenta associated 9 PLAC9 Canis lupus familiaris (Dog) (Canis familiaris) LKKISSTCS;WNTGCDRHM 2 6.3 1.0034 -1.6084 0 0 0 0 0 0 0 3.87578 0 0 0 0 0 0 7.98351 A0A8I3NIZ8 A0A8I3NIZ8_CANLF Phosphotriesterase related PTER Canis lupus familiaris (Dog) (Canis familiaris) catabolic process [GO:0009056] "hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]" IVPKMLLRGI;IVPKMLLRGIT 2 3.6 0.99682 -0.57597 8.34669 0 0 4.57809 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NIZ9 A0A8I3NIZ9_CANLF Syntaxin 12 STX12 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] BLOC-1 complex [GO:0031083]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; postsynaptic recycling endosome [GO:0098837]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] LSVIIVILVFI;RKKICILVLVLSVIIVILV;SLPLPLSASEQRQQKLQ;VERATDQLQRAAYYQKKSR 4 20.4 0.99419 -0.12271 0 7.41507 4.92315 0 0 6.30117 10.3705 0 0 0 0 0 0 0 0 A0A8I3NJ33 A0A8I3NJ33_CANLF Aurora kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; regulation of cytokinesis [GO:0032465] chromosome passenger complex [GO:0032133]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; neuron projection [GO:0043005]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GNVYLAREKQSKFILAIKVLLKAQ;KENCIAGPVKTTIALDFEI 2 46.7 0.97241 0.041303 0 0 0 4.559 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NJ52 A0A8I3NJ52_CANLF Tripartite motif containing 46 TRIM46 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] zinc ion binding [GO:0008270] QEHRSLLDGSGL;VHLHTPPAPVLHF 2 3.3 0.99662 -0.58303 0 0 0 0 0 0 0 12.9943 9.79028 0 0 0 0 0 0 A0A8I3NJ58 A0A8I3NJ58_CANLF Repressor of RNA polymerase III transcription MAF1 MAF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase I [GO:0016479]; negative regulation of transcription by RNA polymerase III [GO:0016480] cytosol [GO:0005829]; nucleoplasm [GO:0005654] RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006] EEEEEEEEEEEDGGGGGSEGGP;FYNKRLKRI 2 11 0.98762 -0.22525 0 0 0 0 8.88405 0 0 0 0 0 0 0 0 0 0 A0A8I3NJ60 A0A8I3NJ60_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLLLLIISLLVLKT;VLKTYGHHLSFLLLLGILQGFV 2 21.2 0.93002 0.10774 0 0 0 0 0 0 0 5.36072 0 0 0 0 4.64403 0 0 A0A8I3NJ62 A0A8I3NJ62_CANLF Potassium voltage-gated channel subfamily Q member 5 KCNQ5 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] CCRYRGWQGRLRFARKPF;GGGGGGGG;LVYLVEKDANKEFSTYADAL;SRIMKFHVAKRKFKETLRP 4 8.1 0.86017 0.14691 0 0 0 3.61953 0 0 0 0 9.90848 0 0 0 0 0 0 A0A8I3NJ69 A0A8I3NJ69_CANLF R-spondin 2 RSPO2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] heparin binding [GO:0008201] APKAKEKKNKKKKRKL;CVGCEVGHWSEWGTCS;GRCFDECPDGFAPLDETMEC;KEKKNKKKKRKLI 4 29.1 0.80332 0.20731 3.93876 0 0 6.00198 0 3.69109 0 0 0 0 5.19298 0 0 0 0 A0A8I3NJ82 A0A8I3NJ82_CANLF Olfactory receptor OR8G6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVVVLCFS 1 2.5 0.98481 -0.25882 0 0 0 0 0 0 8.53169 0 0 0 0 0 0 0 0 A0A8I3NJ90 A0A8I3NJ90_CANLF Discs large MAGUK scaffold protein 2 DLG2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120] basolateral plasma membrane [GO:0016323]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] kinase binding [GO:0019900] DPDCFTPMICHCKVACTNNT;IVRLYVRRRRPI;QPSVTLQRAISLE;VIEEQSGP;VIPSKRRVER 5 7.1 0.98248 -0.24853 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.43492 A0A8I3NJ96 A0A8I3NJ96_CANLF Transmembrane protein 38B TMEM38B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] identical protein binding [GO:0042802]; potassium channel activity [GO:0005267] VASDTVKKKHTKKTE;VGGVKHANSYYKNSWI 2 11.2 0.98906 -0.52435 0 0 0 0 0 0 0 0 0 0 0 0 16.8718 0 0 A0A8I3NJA1 A0A8I3NJA1_CANLF Polypyrimidine tract binding protein 2 PTBP2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] mRNA binding [GO:0003729] GALSPLAIPNAAAAAAAAAAG;LALDGQNIYNACCTLRI;LVSNLNEE;SNLNEEVFMEMCS 4 15.9 1.0012 -0.95066 0 0 10.3228 8.98763 0 0 0 9.52425 0 0 0 11.7228 0 0 0 A0A8I3NJA8 A0A8I3NJA8_CANLF Nuclear factor of activated T cells 3 NFATC3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AGSLSPHHSPVPSPG;IPSSIMHQPFQVTPTPP;LPSHSSVLSSSFQL;NPAVTAAVQVHFYLCN;VLSSSFQLQGHKNY 5 6.4 0.98758 -0.32586 0 0 0 0 0 0 11.8607 0 15.8086 0 11.636 11.6973 9.70219 10.5096 0 A0A8I3NJB4 A0A8I3NJB4_CANLF alanine transaminase (EC 2.6.1.2) GPT Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] DEVYQDNVYAEG;PIPQYPLYSAALAELN;VINPGNPTGQVQ;YLDEERTWAL 4 8.8 1.0022 -1.3666 0 8.80106 6.54751 0 0 9.02583 0 0 0 0 0 0 8.56003 0 0 A0A8I3NJB5 A0A8I3NJB5_CANLF UPAR/Ly6 domain-containing protein GPIHBP1 Canis lupus familiaris (Dog) (Canis familiaris) DDDDDEEE;EEEDDDADFGLDGYDDDDDDEEEEA;GLDGYDDDDDDEEEEA;TASDRQNWQGHQLGAHGED 4 12.6 0.9937 -0.1495 0 0 0 0 0 9.53632 0 0 0 7.71795 0 5.07236 0 0 0 A0A8I3NJC3 A0A8I3NJC3_CANLF EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT Canis lupus familiaris (Dog) (Canis familiaris) protein O-GlcNAcylation via threonine [GO:0097370] endoplasmic reticulum lumen [GO:0005788] protein O-acetylglucosaminyltransferase activity [GO:0097363] DLARLRGVHYITWRRQ;EVQIVDYKYKE;EVQIVDYKYKEL;EVQIVDYKYKELG;GVNMYHHFCDF;HPTLGEHP;IEKPTYFMKLDAGVNMY;KLLVLGVLLH;LPDWAAVFELYNC;TLEVQIVDYKY 10 19.2 1.0035 -2.2097 10.1079 10.6053 7.20144 0 9.94527 0 0 6.07035 6.83302 5.21447 0 7.93044 6.94158 0 10.6131 A0A8I3NJC9 A0A8I3NJC9_CANLF Macrophage scavenger receptor 1 MSR1 Canis lupus familiaris (Dog) (Canis familiaris) receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] membrane [GO:0016020] scavenger receptor activity [GO:0005044] LKSLKAALIILYLLVFVVLIPII;RFQEVVMEQMSN;SIEECKIRQWG;VGKTGRTAPFKTVRLVGGKA 4 15.1 0.97384 0.048206 0 0 0 0 0 4.30838 0 0 0 0 0 0 0 0 0 A0A8I3NJD0 A0A8I3NJD0_CANLF Mitochondrial import inner membrane translocase subunit LMNB2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] mitochondrial inner membrane [GO:0005743] FGSSGGGK 1 8.4 0.98939 -0.26592 0 0 0 0 9.65295 0 0 0 0 0 0 0 0 0 0 A0A8I3NJD1 A0A8I3NJD1_CANLF 60S ribosomal protein L10a Canis lupus familiaris (Dog) (Canis familiaris) maturation of LSU-rRNA [GO:0000470] cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020] RNA binding [GO:0003723] LKKLNKNKKLVKKLE;LVKKLESLIKQIPRILGP;VGNQTAPWSPNRLYVSCFLYFGNKQ 3 15.1 0.99263 -0.19257 0 0 0 0 0 0 0 0 0 0 0 0 10.213 0 0 A0A8I3NJD4 A0A8I3NJD4_CANLF BMP and activin membrane bound inhibitor BAMBI Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of cell shape [GO:0008360]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] frizzled binding [GO:0005109] EAPSWPANAH;EAPSWPANAHSRE;PANAHSRESRCSSEEG;SENKRLQDQRQQMLSRLH 4 13.3 0.98551 -0.43004 7.07703 8.01987 0 8.98524 0 0 0 7.52372 0 0 0 0 0 0 0 A0A8I3NJD5 A0A8I3NJD5_CANLF Receptor protein-tyrosine kinase (EC 2.7.10.1) EGFR Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; positive regulation of epithelial cell proliferation [GO:0050679]; regulation of cell communication [GO:0010646]; regulation of signaling [GO:0023051] basal plasma membrane [GO:0009925]; receptor complex [GO:0043235] ATP binding [GO:0005524]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006] ATGIVGGLLLVVVVALGVGLFLRRR;GLFLRRRHIVRKRTLRRLL;GTSNRLTQLGTFE;GVGLFLRRRHIVRKRTLRRL;GVGLFLRRRHIVRKRTLRRLLQER;HIVRKRTLRRLLQ;KCKKCEGPCRKVCNGI;LFLRRRHIVRKRTLRRLLQ;SDCCHNQC;SDCCHNQCAAGCTGPRESDCLV;SSEGCWGPGPRDCVSCRNVSRG;TDHGSCVRACSSDSYEVEEDGV;TDLHAFENLEII;VGLFLRRRHIVRK;VGLFLRRRHIVRKRTLRR;VLSNYGSNKTGLQELPLR 16 15.2 1.0024 -1.0125 11.6172 10.6543 6.25227 9.11876 6.22963 8.30538 14.5903 6.70874 14.5043 4.01033 9.51448 4.5456 0 10.0423 3.93206 A0A8I3NJD8 A0A8I3NJD8_CANLF "WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2" WFIKKN2 Canis lupus familiaris (Dog) (Canis familiaris) muscle cell development [GO:0055001]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179] extracellular space [GO:0005615] receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431] QECETYEKCCP;TTLESGPNGTAFPAAE;YGGCEGNSNNFESREACEESC 3 8.3 0.88578 0.13189 0 0 7.92303 0 5.03087 0 9.12554 0 0 0 0 0 0 10.7525 0 A0A8I3NJE5 A0A8I3NJE5_CANLF Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) MINDY3 Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked deubiquitination [GO:0071108]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] DILESACC;FIPDSLLEDVMKALDLVSDP 2 6.7 1.0012 -0.74612 0 0 0 0 0 0 11.2017 0 0 0 0 0 0 0 0 A0A8I3NJE8 A0A8I3NJE8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TSSSSWYSASCC 1 7.9 0.95241 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 3.55275 0 0 A0A8I3NJF6 A0A8I3NJF6_CANLF ATP binding cassette subfamily E member 1 ABCE1 Canis lupus familiaris (Dog) (Canis familiaris) rescue of stalled ribosome [GO:0072344]; translational termination [GO:0006415] cytosolic ribosome [GO:0022626]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; endoribonuclease inhibitor activity [GO:0060698]; GTPase activity [GO:0003924] WMTRLNQNIE 1 1.6 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 7.07414 0 0 0 0 0 A0A8I3NJF8 A0A8I3NJF8_CANLF Ankyrin repeat domain 26 Canis lupus familiaris (Dog) (Canis familiaris) RGELPLGFNISP;VSIAEKLL 2 9.9 0.95383 0.05044 0 0 0 0 0 0 0 0 0 0 7.92434 0 0 0 0 A0A8I3NJH1 A0A8I3NJH1_CANLF Insulin-like growth factor-binding protein 1 ADCY1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] insulin-like growth factor binding [GO:0005520] EITQEQLLENFHLMVPSEEDTPIL;ETALPAGCGCCPMC 2 15.3 0.93295 0.060802 0 2.80066 0 0 0 0 0 0 0 7.36501 0 0 0 0 0 A0A8I3NJH9 A0A8I3NJH9_CANLF Apolipoprotein F APOF Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] PERARRSLPINDCEQE;WSGGPTGV 2 6.9 1.0028 -1.3785 0 0 0 0 0 0 0 0 8.14364 0 0 0 0 0 0 A0A8I3NJI0 A0A8I3NJI0_CANLF Olfactory receptor OR2T6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ICNPLRYPVLMSHQVCWMILASSW;VLMSHQVCWMILAS 2 7.8 0.9969 -0.094323 0 8.72206 0 0 0 0 0 11.4549 0 0 0 0 0 0 0 A0A8I3NJJ5 A0A8I3NJJ5_CANLF Bromodomain containing 3 BRD3 Canis lupus familiaris (Dog) (Canis familiaris) endodermal cell differentiation [GO:0035987]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromatin [GO:0071168] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; lncRNA binding [GO:0106222]; lysine-acetylated histone binding [GO:0070577]; molecular condensate scaffold activity [GO:0140693] ALWETPHPEKDA;YDSEEEEEGLP 2 3.1 0.94062 0.085931 9.63341 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NJJ8 A0A8I3NJJ8_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSBG2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; mitochondrion [GO:0005739] arachidonate-CoA ligase activity [GO:0047676]; fatty acyl-CoA hydrolase activity [GO:0047617] GPGHETPLTIP;MFGVHDTT;PIGEMYGM;PLNPETSEF;VTPRLWTIHRDG;WNDFMELGNSIPDSQ 6 9.2 0.99908 -3.0523 12.0678 12.2147 11.0784 0 8.89266 9.67379 12.1993 12.2628 12.2112 9.71788 11.7968 7.81782 11.024 11.2065 12.0209 A0A8I3NJK0 A0A8I3NJK0_CANLF Thioredoxin-like protein TXNL4B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682] PVYTHYFDISYIPS;SPDHTKFVGSFKTKQD;VLRFGRDEDPV 3 27.5 0.98742 -0.47955 0 0 0 7.96064 0 0 0 0 0 0 0 0 9.53955 0 0 A0A8I3NJK2 A0A8I3NJK2_CANLF Keratin 32 KRT32 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] CQLGDRLNI 1 2 1.0038 -0.80421 0 8.21349 0 0 0 0 0 0 0 0 0 0 0 0 5.92678 A0A8I3NJK6 A0A8I3NJK6_CANLF Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine-gated channel complex [GO:0005892]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] IYPDVTYYFV;WLFIIVCFLGTVGLFLPP 2 5.5 0.99276 -0.048568 15.7945 0 0 0 0 0 0 0 0 15.7372 0 0 15.9535 0 11.1209 A0A8I3NJL0 A0A8I3NJL0_CANLF VWFA domain-containing protein ANTXRL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] signaling receptor activity [GO:0038023] EITNLEPSTF;GVAEKVGSSSLWVPAP;LLLLLLLP;PALPLLLLLLL 4 6.6 0.98912 -0.26302 0 0 0 0 0 0 0 0 0 0 0 0 10.3528 0 0 A0A8I3NJL3 A0A8I3NJL3_CANLF Protein tyrosine phosphatase 4A3 PTP4A3 Canis lupus familiaris (Dog) (Canis familiaris) EDAIQFIRQ 1 10.3 1.0044 -0.80421 0 0 7.40131 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NJM1 A0A8I3NJM1_CANLF Kelch like family member 20 KLHL20 Canis lupus familiaris (Dog) (Canis familiaris) ISDKHPRQTL;TVERYNPQENRWHTI 2 4.5 0.9939 -0.022299 10.7432 0 0 0 0 0 0 0 0 0 0 5.65635 0 0 0 A0A8I3NJM3 A0A8I3NJM3_CANLF Olfactory receptor OR2A9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CITLMVASWACGSLLA;LFNPMLNP 2 7.7 0.99333 -0.053801 11.7839 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NJM5 A0A8I3NJM5_CANLF TMF1 regulated nuclear protein 1 TRNP1 Canis lupus familiaris (Dog) (Canis familiaris) cerebellar cortex morphogenesis [GO:0021696]; neural precursor cell proliferation [GO:0061351]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127] euchromatin [GO:0000791]; nucleus [GO:0005634] DNA binding [GO:0003677] PALLASAL 1 3.6 1.0044 -1.1044 0 0 0 0 0 5.42797 0 0 0 0 0 0 0 0 0 A0A8I3NJM7 A0A8I3NJM7_CANLF Aryl hydrocarbon receptor repressor AHRR Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein dimerization activity [GO:0046983] IVDYLGFHQTDVMHQNIYD;LDSGLPPS;PIEDTKFRGGPMPL;RDRLNAELDHL 4 7.4 0.99757 -0.089722 0 0 0 0 0 9.99039 10.2288 9.74317 11.2567 0 0 0 0 0 0 A0A8I3NJN1 A0A8I3NJN1_CANLF Small ribosomal subunit protein mS29 DAP3 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] mitochondrial ribosome [GO:0005761]; small ribosomal subunit [GO:0015935] LDPGRFLHRGSP 1 3.3 0.984 -0.24456 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.83678 A0A8I3NJN3 A0A8I3NJN3_CANLF Ankyrin repeat and BTB domain containing 3 BTBD11 Canis lupus familiaris (Dog) (Canis familiaris) protein heterodimerization activity [GO:0046982] AADSVRSSNLSL;CCSDSHPASPYGGS;DLDEVPWTLQEL;LVSRAMHHLQPLNAKHH;NTALVEDSEGLDCAGQHCS;QDLGFRMLNCGRTDLVKQAVS;SVEHGEENYSETP;YFMHCPQMEWEN 8 12.2 1.0007 -0.63171 9.94524 0 0 4.41515 0 0 10.2523 8.17153 9.19239 0 6.98482 0 0 0 0 A0A8I3NJP0 A0A8I3NJP0_CANLF Liver-expressed antimicrobial peptide 2 LEAP2 Canis lupus familiaris (Dog) (Canis familiaris) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to bacterium [GO:0042742] extracellular region [GO:0005576] ECITRLCRKR 1 13 0.99084 -0.27478 0 0 0 0 0 0 0 0 0 0 0 10.1821 0 0 0 A0A8I3NJP2 A0A8I3NJP2_CANLF Uncharacterized protein COMMD5 Canis lupus familiaris (Dog) (Canis familiaris) DLEKKCEL;GAAAPYLHHP;GAQLPPQVAAM;LDRGTFRKLLKL 4 18.3 1.0019 -0.67402 11.839 0 0 0 0 10.8849 0 0 0 0 0 0 0 0 0 A0A8I3NJP6 A0A8I3NJP6_CANLF Iron-responsive element-binding protein 2 IREB2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "4 iron, 4 sulfur cluster binding [GO:0051539]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]" EERVVLSMFKV;FSLTFPEE;GKPAPKTI;HVLLYLGDSVTTDHI;PREFNSYGARRGN;SFFPVDNVTLKHL;YVCIRYEGSEYTLSHGSVVL 7 9.5 1.0045 -1.0458 6.30586 0 0 0 0 10.0591 11.3474 0 0 0 0 0 0 0 5.56958 A0A8I3NJR1 A0A8I3NJR1_CANLF Leucine rich repeat containing 59 LRRC59 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; mitochondrial nucleoid [GO:0042645] AVLKLLLLLLL;CANKVLQHMKAV;VLKLLLLLL 3 7.5 1.0041 -1.0828 7.34376 0 7.38059 0 10.1956 4.31237 0 6.93723 0 0 4.35797 0 0 0 0 A0A8I3NJS4 A0A8I3NJS4_CANLF Olfactory receptor LOC485225 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FDRYVAICDPLRYTMVL;IFWFHAGE;IFWFHAGEISLDGCVTQ;NPIIYGVKTKQ 4 13.9 1.002 -0.68908 0 0 13.9861 0 0 6.87049 0 0 0 0 0 0 0 0 0 A0A8I3NJS5 A0A8I3NJS5_CANLF Zinc finger protein 572 ZNF572 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CWKTFSQSSTLVI;EQKLLVSDSSGFQERESLKSPFTG;GNEIWCNDSYENDGKSENQGNSKG;KCSDCDKCFSRS;SECGKCFSN 5 15.6 1.0027 -1.144 0 6.51603 0 0 0 8.47098 0 12.2725 0 0 0 0 7.19957 0 9.68958 A0A8I3NJT4 A0A8I3NJT4_CANLF Myogenic factor MYOD1 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to oxygen levels [GO:0071453]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; myoblast fate determination [GO:0007518]; myoblast fusion [GO:0007520]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of myoblast proliferation [GO:2000818]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber adaptation [GO:0043503]; skeletal muscle fiber development [GO:0048741]; transcription by RNA polymerase II [GO:0006366]" euchromatin [GO:0000791]; myofibril [GO:0030016]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "bHLH transcription factor binding [GO:0043425]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; nuclear receptor binding [GO:0016922]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]" NCYDGTYYSEAP;PALLLAEAP;RKAATMRERRRLSKVNEAFETLKRC;RLPKVEILRNAIRYIEG 4 19.7 1.002 -0.67201 0 0 0 0 0 0 0 8.29664 0 0 0 0 6.07573 5.61338 8.3189 A0A8I3NJT8 A0A8I3NJT8_CANLF Platelet activating factor acetylhydrolase 2 PAFAH2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847] AFLQKHLDLKED;LDAWMFPLEH;SLEEEWIPHRQIEEGE 3 9.7 0.99162 -0.51178 0 0 0 0 0 0 9.22937 0 8.99952 0 0 0 0 0 5.93826 A0A8I3NJU5 A0A8I3NJU5_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC119866315 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AYYVVAVAIFCS;YCFVTVGE 2 3.3 0.99062 -0.21316 0 0 0 0 0 10.8721 0 0 0 0 0 8.36859 0 0 0 A0A8I3NJU8 A0A8I3NJU8_CANLF Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) MED30 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] MQLPNGVTYHTGTYQ;NENCGGMD 2 16.1 1.005 -1.0505 0 0 0 0 4.38722 0 0 0 0 0 0 0 0 7.05072 0 A0A8I3NJV1 A0A8I3NJV1_CANLF Paired box 5 PAX5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEYKRQNPTMFAWEIRDR;PGLLGSPYYYSAAA 2 9.2 0.98443 -0.25298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.27712 A0A8I3NJV2 A0A8I3NJV2_CANLF "5'-nucleotidase, cytosolic IIIB" NT5C3B Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287] HYYPIEIDPHR;NYMDFDEDVEERRERYM 2 14 0.98406 -0.25519 0 0 0 0 10.36 0 0 0 0 0 0 0 0 0 0 A0A8I3NJV6 A0A8I3NJV6_CANLF CXADR like membrane protein CLMP Canis lupus familiaris (Dog) (Canis familiaris) digestive tract development [GO:0048565] bicellular tight junction [GO:0005923]; cytoplasmic microtubule [GO:0005881]; membrane [GO:0016020] VILKVLVRP 1 2.5 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 8.50835 0 0 A0A8I3NJW2 A0A8I3NJW2_CANLF Olfactory receptor family 8 subfamily D member 6 OR8D6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISSQLHMPMYY 1 3.5 0.98579 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5573 A0A8I3NJX4 A0A8I3NJX4_CANLF phosphorylase kinase (EC 2.7.11.19) PHKG2 Canis lupus familiaris (Dog) (Canis familiaris) glycogen catabolic process [GO:0005980] cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] GVILFTLLAGSPPFWHR;RSLLEAVSFLHANNIVHRDLKPE 2 9.9 0.93667 0.092542 0 0 0 0 0 0 9.11728 5.98014 0 0 0 0 0 0 0 A0A8I3NJY5 A0A8I3NJY5_CANLF "Pleckstrin homology, MyTH4 and FERM domain containing H3" PLEKHH3 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] GALYAPLLPLPYS;RKHSVRLCSPRQ 2 3.2 0.9179 0.11019 0 0 0 0 0 0 4.32186 0 0 0 0 8.41151 0 0 0 A0A8I3NJZ8 A0A8I3NJZ8_CANLF Olfactory receptor OR52B4 Canis lupus familiaris (Dog) (Canis familiaris) cognition [GO:0050890] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KQIREQVVHVLFTRQK;TVPQALAIFCFHAG 2 9.5 0.98939 -0.19677 0 0 0 0 9.97699 0 0 0 0 0 0 0 0 0 8.53185 A0A8I3NK00 A0A8I3NK00_CANLF LYR motif-containing protein 9 LYRM9 Canis lupus familiaris (Dog) (Canis familiaris) PLQLYRYLL 1 11.5 1.0046 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.4631 A0A8I3NK01 A0A8I3NK01_CANLF Zinc finger protein 556 ZNF556 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]" ENWEDQCIEDKYNNEEGHLNHMVER 1 5.7 0.97712 0.035538 7.06673 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NK09 A0A8I3NK09_CANLF Proline rich coiled-coil 1 PRRC1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] HSVESMITT;LPDKWFDIGCLIV;PVSVPSGPAL;VLDKTKHSVE 4 9 1.003 -1.7412 0 0 0 0 5.7879 0 0 0 0 0 0 0 0 0 0 A0A8I3NK10 A0A8I3NK10_CANLF Epithelial splicing regulatory protein 2 ESRP2 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] mRNA binding [GO:0003729] FFSFYDLRREFHVQ;LMGGTLGRSGMSP;LPAARVPAA;SVADPRPAPGPLVVLFGATA;YPSPPVSPTTVGYL 5 10.4 0.98804 -0.50529 11.9824 10.1149 0 0 0 0 6.56024 0 0 0 15.9338 0 0 9.02719 0 A0A8I3NK24 A0A8I3NK24_CANLF MICAL like 2 MICALL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; substrate adhesion-dependent cell spreading [GO:0034446] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; actinin binding [GO:0042805]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] DEEPSGKK;RARLKPVEKKHPAERVLGEP 2 3.1 0.99727 -0.10206 0 0 0 8.78875 0 0 0 9.4717 0 4.39643 0 0 0 0 0 A0A8I3NK28 A0A8I3NK28_CANLF RUN and SH3 domain containing 1 RUSC1 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; microtubule cytoskeleton [GO:0015630] actin binding [GO:0003779] LCNLNHIHLQHVSLG;LSTSPPPG;SGASSPRSPGLDSNRNTLTTCQ 3 5 1.0022 -1.271 0 0 0 0 0 0 7.16651 0 0 6.15084 0 9.56664 0 9.87787 0 A0A8I3NK29 A0A8I3NK29_CANLF "Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" LONP1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; oxidation-dependent protein catabolic process [GO:0070407]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515] mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252] EVKNKKLVELLRRKVRLAQPYA;IEVKNKKLVELLRRKVRL;KIIEVKNKKLVELLRRKVRLA;LEKDDKDA;SPGEVLMVEVENI;VERMYDVTPPGV 6 6.5 1.0044 -0.81915 5.50602 7.83099 6.47517 0 0 0 10.8199 0 6.05085 0 0 0 9.19091 0 0 A0A8I3NK31 A0A8I3NK31_CANLF KASH5-like coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CELVLAQSAENNETEWQCSLFSL;DYTELRHQIKSAHQAIKRT;EEENNKFKLALETLE;EELLTSIFHACD;KTEIEYQMQL;LETLEEAN;SLDIMMDQEM;TTDKTESTSWSFEA;YPVSLTSSENLS 9 8.2 1.0027 -1.4909 8.71394 8.56544 12.2628 11.459 11.6186 11.7936 15.3391 8.97269 8.21631 12.9438 12.9832 13.2328 0 11.0442 10.448 A0A8I3NK32 A0A8I3NK32_CANLF Interleukin-1 IL36G Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] SLQLKKKKL 1 5.9 1.0042 -0.80421 0 0 0 0 0 0 0 0 5.05511 0 0 0 0 0 0 A0A8I3NK34 A0A8I3NK34_CANLF ATP-dependent RNA helicase DHX30 (EC 3.6.4.13) (DEAH box protein 30) DHX30 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial nucleoid [GO:0042645]; nucleus [GO:0005634] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] ENYLEENLLYAPSLRFIHG;GILLRKLQSNPS;IDVTDFLS;KIETFLNHYPVD;KYRVLADRFGSPA;LGQRLAHI;LILLKGLQR;QIATSSSTA;RLEKMVPFQVPEI;SMTQQDSHTSL;VIVDEVHERDVN 11 10.8 0.99908 -3.2011 3.72148 4.15534 8.79139 0 0 0 10.8234 0 9.04111 0 4.00782 10.1206 8.79708 0 5.76681 A0A8I3NK36 A0A8I3NK36_CANLF sphingomyelin phosphodiesterase (EC 3.1.4.12) SMPD3 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; peptide hormone secretion [GO:0030072]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; regulation of protein phosphorylation [GO:0001932]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685] extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786] HPDEAFDHEVSAF;QQHSLFTHYKDPCRLGP;TDNLYDEEVCTP;VASLPFAF;VLYTAPFPNSCLSALH 5 10 1.0021 -1.8831 0 0 0 0 0 0 0 0 6.47967 11.5347 0 0 0 0 4.32589 A0A8I3NK43 A0A8I3NK43_CANLF Transient receptor potential cation channel subfamily C member 7 TRPC7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; plasma membrane [GO:0005886] "inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" DEDGTRFSHDITPIILAAH;PEVAYFTYARDKWWP;PHDYFCKCNECT;PVLTALEL;VLTALELSN 5 7.5 0.9886 0.019257 0 11.4042 0 4.9905 0 0 10.2036 7.43571 0 0 0 0 11.479 10.5712 7.76188 A0A8I3NK59 A0A8I3NK59_CANLF Shisa family member 3 SHISA3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090] AGEYCHGWVDAHGGDHEGFQCPED;EPSQQPIRFSLRSYQTEALPMILP 2 20.2 0.94727 0.082605 0 0 6.45631 0 0 0 0 7.86468 0 0 0 0 0 0 0 A0A8I3NK69 A0A8I3NK69_CANLF Protein MAK16 homolog MAK16 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] EDDEVDESDISDFE;IRKLTLKRQRKLVPLS;TKITQYLIRIRKLTLKRQRKLVP 3 13.2 0.84664 0.15625 0 0 4.13791 0 0 0 0 0 0 0 0 9.63865 6.23053 0 8.8553 A0A8I3NK75 A0A8I3NK75_CANLF Netrin receptor UNC5 UNC5A Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior axon guidance [GO:0033564] plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] AVIVYVNGGWSTWTEWSVC;IAVAVCLLLLLLVL;LSVAATKRLKLLLFAPVA;LYVGLIAVAVCLLLLLLVLILV;SLDPPCSRGAD;STQNYFRSL;TKSQKAYIRI;VGEALSVAATKRLKL;VGEALSVAATKRLKLLLFAPV;VGLIAVAVCLLLLLLVLILV;VILAMDHCGE;VSLEQGIVLPCR 12 13.7 0.99096 -0.27522 0 0 0 0 0 0 0 11.8511 0 0 0 0 0 0 0 A0A8I3NK89 A0A8I3NK89_CANLF HEAT repeat containing 5A HEATR5A Canis lupus familiaris (Dog) (Canis familiaris) DIALAQEMKKRDSRNDF;LGAAATPCHRDVYK;LGPELQGNSTSI;LQKRCIEKFK;LVSCLCVNLCSPY;TTVTCVDTMQEEEGDKG;VEFLCSLRSDATM;VERHKSHRQPLKTI 8 5.8 0.93965 0.060502 0 0 0 0 0 0 0 0 0 0 0 0 0 6.67243 0 A0A8I3NK95 A0A8I3NK95_CANLF Farnesylated proteins-converting enzyme 2 RCE1 Canis lupus familiaris (Dog) (Canis familiaris) CAAX-box protein processing [GO:0071586] endoplasmic reticulum membrane [GO:0005789] metalloendopeptidase activity [GO:0004222] GSIFLSAGHLIGPVLC;PKLYGSLPLCV;WARCLTDMRWLRNQVI 3 14 0.99455 -0.12581 0 0 9.35986 0 0 0 0 0 0 0 0 0 8.45615 9.43632 0 A0A8I3NK96 A0A8I3NK96_CANLF Splicing factor 3b subunit 4 SF3B4 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723]; splicing factor binding [GO:1990935] HPGMSQMQLAHHGP 1 3.3 0.98694 -0.22989 0 0 0 0 8.67807 0 0 0 0 0 0 0 0 0 0 A0A8I3NKA9 A0A8I3NKA9_CANLF Uncharacterized protein BNIP3L Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; mitochondrial outer membrane permeabilization [GO:0097345]; positive regulation of apoptotic process [GO:0043065] endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635] identical protein binding [GO:0042802] DWSSRPENIPP;GVPSSPGNASSPPRRLLCCHHV;SSSATMSSHLVEQPPP 3 16.3 0.99237 -0.19371 0 0 0 0 0 7.61405 0 0 0 0 0 0 0 0 0 A0A8I3NKB3 A0A8I3NKB3_CANLF Tyrosine hydroxylase TH Canis lupus familiaris (Dog) (Canis familiaris) dopamine biosynthetic process from tyrosine [GO:0006585]; heart development [GO:0007507]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666] axon [GO:0030424]; cytoplasm [GO:0005737]; perikaryon [GO:0043204] iron ion binding [GO:0005506]; tyrosine 3-monooxygenase activity [GO:0004511] GENKGEWAGRGRQARRGCQE;SLGASDEEIEKLSTL 2 7.3 0.98409 -0.24251 0 0 0 0 0 0 9.9188 0 0 0 0 0 0 0 0 A0A8I3NKB4 A0A8I3NKB4_CANLF histone acetyltransferase (EC 2.3.1.48) KAT7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] histone acetyltransferase activity [GO:0004402]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] DLDLFRRAQ;KRNAGSSSDGTEDSDFSTDLEH 2 6.6 0.99005 -0.26622 0 5.8798 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NKB8 A0A8I3NKB8_CANLF DAN domain BMP antagonist family member 5 DAND5 Canis lupus familiaris (Dog) (Canis familiaris) atrial septum development [GO:0003283]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; sequestering of nodal from receptor via nodal binding [GO:0038101]; ventricular septum development [GO:0003281] extracellular region [GO:0005576] morphogen activity [GO:0016015] AATNQTQALGRGLPGSQ;QLWAATNQTQ 2 10.5 1.0031 -0.86896 0 0 0 0 0 0 0 8.9068 0 0 0 9.59001 0 0 0 A0A8I3NKC0 A0A8I3NKC0_CANLF ArfGAP with dual PH domains 2 ADAP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTPase activator activity [GO:0005096]; phosphatidylinositol bisphosphate binding [GO:1902936] AGTGNAYCADCGAADPD;LVLKEQWIRAKYER;WFNALRAARLQ 3 12.2 0.99194 -0.034458 0 0 0 4.34376 0 0 0 0 0 0 8.36286 0 9.07197 0 0 A0A8I3NKC9 A0A8I3NKC9_CANLF Insulin-induced gene protein INSIG1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] EPHKFKREWASV 1 4.4 0.94209 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 8.78139 0 0 A0A8I3NKE0 A0A8I3NKE0_CANLF EMAP like 5 EML5 Canis lupus familiaris (Dog) (Canis familiaris) CVWKDHILCRIV;FDISWDLYQPNKLVSCGVKHIKFW;GVCAVDFSADGKRLA;GVIYNRQQN;HTHGIACLAFDLDGQIFDIS;IVVHERNKPFLIM;NVATGTQSFYQEH;RDRRCAIHDI;VGLDPEHTIT;VHTHGIACLAFDL 10 6.4 0.95646 0.050752 0 0 0 0 0 0 9.86378 0 0 0 0 0 0 0 0 A0A8I3NKE8 A0A8I3NKE8_CANLF Endoplasmic reticulum lectin (Protein OS-9) OS9 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]" endoplasmic reticulum lumen [GO:0005788] carbohydrate binding [GO:0030246] AAESLLSGLLRLLLLGLLL;DEDEDEDEQQ;DEDEDEDEQQLL;DEDEDEDEQQLLGEFE;DHQNEVEEEEEEEEDED;EEEDEDEDEDEQQL;EEEEEDEDEDEDEQQ;EKDKSDMDHQNEV;EKDKSDMDHQNEVEEEEEE;GAEGAEEDSHWLTD;LLRLLLLG;RVTKLRHG;SLLSGLLRLLLLGLLLP;VEEEEEEEEDEDEDE;VGSLNLEEL 15 13.2 1.0031 -2.3269 9.56173 4.41474 0 0 0 15.9156 6.84323 4.26093 3.73585 9.04641 7.87049 7.84235 0 9.271 0 A0A8I3NKF0 A0A8I3NKF0_CANLF Homeobox A3 HOXA3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; animal organ formation [GO:0048645]; anterior/posterior pattern specification [GO:0009952]; blood vessel remodeling [GO:0001974]; cartilage development [GO:0051216]; embryonic skeletal system morphogenesis [GO:0048704]; gene expression [GO:0010467]; glossopharyngeal nerve morphogenesis [GO:0021615]; parathyroid gland development [GO:0060017]; positive regulation of stem cell proliferation [GO:2000648]; specification of animal organ position [GO:0010159]; stem cell proliferation [GO:0072089]; thymus development [GO:0048538]; thyroid gland development [GO:0030878] nucleoplasm [GO:0005654] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]" SPPPFSKPPQGAYG 1 3.2 0.98307 -0.25395 0 0 0 0 0 0 14.8838 0 0 0 0 0 0 0 0 A0A8I3NKF3 A0A8I3NKF3_CANLF Roundabout guidance receptor 4 ROBO4 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; establishment of endothelial barrier [GO:0061028] EEDQDSVLTPE;QDSVLTPEEVALCLE;TASGGPGAPWA;TDASSPPSPRDDLFLTST;VILECGPPWGHPEPTVSWWKDGKPL;VTGGTAQDSPPQILVHP 6 8.5 1.0028 -0.89412 0 9.11811 0 0 0 13.6575 0 9.96073 0 0 0 0 0 0 0 A0A8I3NKH7 A0A8I3NKH7_CANLF A-kinase anchoring protein 6 AKAP6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSSSVAFFFFY 1 4.7 0.98947 0.035491 0 0 6.56645 6.99107 7.09993 0 0 0 0 6.5979 6.65935 0 7.11686 6.61944 0 A0A8I3NKH8 A0A8I3NKH8_CANLF Nicotinamide riboside kinase 1 NMRK1 Canis lupus familiaris (Dog) (Canis familiaris) FDGHVWPMYLK 1 6.5 0.98481 -0.2549 0 0 0 0 8.60077 0 0 0 0 0 0 0 0 0 0 A0A8I3NKH9 A0A8I3NKH9_CANLF Thymidine kinase 2 TK2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] deoxycytidine kinase activity [GO:0004137]; thymidine kinase activity [GO:0004797] EGAGGGGAGRGAGAEGAGGAEGAG;VLAEWFDWILKNIDVSV 2 11.4 0.98932 -0.52072 0 0 0 0 0 0 0 0 12.0984 0 0 0 0 0 0 A0A8I3NKK4 A0A8I3NKK4_CANLF SH3 and multiple ankyrin repeat domains 2 SHANK2 Canis lupus familiaris (Dog) (Canis familiaris) APSVVSSHSVLSFS;GVAWQAGLRTGDFL;PSQPANCA;TTDHLLQE;TTDHLLQEE;VDTCTVYADGQAFTVD;VGSYDSFDATSDCIIEEK 7 4.6 1.002 -1.2904 0 11.1749 0 8.90026 7.50438 0 0 0 8.32477 11.2809 0 8.21067 4.17361 0 0 A0A8I3NKK5 A0A8I3NKK5_CANLF Olfactory receptor OR51F1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DTCIIQMFFLHGFTFIES;ILFVIITQKSLHEPMYYFLSMLS;LLMTIRTLVLVVPPLLLLKPLYFCR;LVVPPLLLLKPL;SLHEPMYYFLSM;VLVVPPLLLLK;VPPLLLLK 7 20.8 1.003 -0.83771 0 5.61262 9.1749 0 6.23383 4.87376 0 4.4117 0 3.33328 0 0 9.73944 0 9.00546 A0A8I3NKL0 A0A8I3NKL0_CANLF Myb/SANT DNA binding domain containing 2 MSANTD2 Canis lupus familiaris (Dog) (Canis familiaris) KTLRRCYSRVKEHG 1 2.3 0.9904 -0.26725 0 0 0 0 0 10.7556 0 0 0 0 0 0 0 0 0 A0A8I3NKL2 A0A8I3NKL2_CANLF Family with sequence similarity 107 member B FAM107B Canis lupus familiaris (Dog) (Canis familiaris) PDYIEDDNPEL;SRNHQDLHRELLMNQ;TFQTSIPRPSIIEMP 3 13.4 0.98631 -0.39003 0 0 0 0 8.61945 0 0 0 0 0 8.55067 0 0 8.18279 0 A0A8I3NKL3 A0A8I3NKL3_CANLF Transmembrane emp24 domain-containing protein 5 TMED5 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794] IQTLLRAFEARDRNI 1 6.6 0.953 0.053874 0 0 0 0 0 0 0 0 3.54325 0 0 0 0 0 0 A0A8I3NKN0 A0A8I3NKN0_CANLF Carnosine N-methyltransferase (EC 2.1.1.22) CARNMT1 Canis lupus familiaris (Dog) (Canis familiaris) carnosine metabolic process [GO:0035498]; methylation [GO:0032259] cytosol [GO:0005829]; nucleus [GO:0005634] carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803] DLSMMKYYYECV;ILKNFPKERWDPS 2 6.1 0.91691 0.11002 0 0 0 0 0 0 0 8.11025 10.2482 0 0 0 0 0 0 A0A8I3NKN1 A0A8I3NKN1_CANLF Unconventional myosin-Id MYO1D Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] cell cortex [GO:0005938]; dendrite [GO:0030425]; early endosome [GO:0005769]; myosin complex [GO:0016459]; perikaryon [GO:0043204] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] IPLYNLTGL;IVLFLQKVWRGTLARMRYKR;PLIENGKVVSII;VIGFKPEETQ 4 6 0.985 -0.43753 0 0 0 7.98732 0 0 5.89516 0 0 0 0 9.61278 0 0 0 A0A8I3NKN7 A0A8I3NKN7_CANLF Fc receptor like 2 FCRL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTEELQPEYVNV;LQPEYVNVNPVDVD;PVFILRVPGAQAMAGDVV;SATVRIYFWY;VLGALCGGLGF 5 11.1 1.0024 -0.66463 0 0 0 7.03188 6.765 0 9.12477 0 13.8463 0 0 0 6.14417 0 0 A0A8I3NKQ1 A0A8I3NKQ1_CANLF Leucine zipper tumor suppressor family member 3 LZTS3 Canis lupus familiaris (Dog) (Canis familiaris) DKSRTMTPAGGGGGGL;DPGRDPLLAFAPRPSELGPPD;QVLEERQKAWERELA 3 7.7 0.98771 -0.46738 0 0 0 6.22184 0 0 0 0 0 0 0 0 0 9.22896 0 A0A8I3NKQ4 A0A8I3NKQ4_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) NDUFA11 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrial respiratory chain complex I [GO:0005747] MARTLLQQYLDI 1 8.5 0.98527 -0.24608 0 0 0 11.6736 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NKR2 A0A8I3NKR2_CANLF Uncharacterized protein DCP2 Canis lupus familiaris (Dog) (Canis familiaris) "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" cytoplasm [GO:0005737] 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; manganese ion binding [GO:0030145]; RNA binding [GO:0003723] CSRFILHIPSE;HIPSEERDNAIRVCFQIEL;TGFDIKDYICKDDYIELRINDQLA 3 12.7 1.0017 -0.75107 0 0 0 0 0 0 9.95408 0 0 0 0 0 0 13.4887 0 A0A8I3NKS3 A0A8I3NKS3_CANLF Tissue factor (TF) F3 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] membrane [GO:0016020] FLVIGIVVLVVIIFTIILSVSLY;FREMFLVIGIVVLVVIIFTIILS;HVYTVQISPRLGN 3 14 0.98994 -0.22317 0 0 6.37236 0 0 0 0 0 0 0 0 0 6.53924 0 0 A0A8I3NKS6 A0A8I3NKS6_CANLF Rho GTPase activating protein 5 ARHGAP5 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell migration [GO:0010631]; mammary gland development [GO:0030879]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; signal transduction [GO:0007165] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] GTPase activator activity [GO:0005096]; SH2 domain binding [GO:0042169] EEFQEMLFEHSELFYDL;EEIEHLNWSEALKLMEKRAD;FKQKSYPDEIYAVPD;NEAIKELMTEGEHIATEITAKF;SLSQYHRQTEVFTLFFSDVL;YLSDNTRESTHQSE 6 7.2 0.9901 0.022487 0 9.43958 9.60642 0 0 0 7.8475 0 10.9336 0 6.20963 0 0 10.2201 0 A0A8I3NKT2 A0A8I3NKT2_CANLF phosphorylase kinase (EC 2.7.11.19) PHKG1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] phosphorylase kinase complex [GO:0005964] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] QMKRGELFDYLTEKV 1 3.6 0.95154 0.053874 0 0 0 0 0 0 0 0 0 0 5.28899 0 0 0 0 A0A8I3NKT4 A0A8I3NKT4_CANLF "Abhydrolase domain containing 17A, depalmitoylase" ABHD17A Canis lupus familiaris (Dog) (Canis familiaris) protein localization to membrane [GO:0072657]; regulation of postsynapse organization [GO:0099175] endosome membrane [GO:0010008]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] palmitoyl-(protein) hydrolase activity [GO:0008474] ARYTVLFSHGNAVDLGQ;ISCMYVRCV 2 8.4 1.0027 -0.75799 6.55219 0 0 0 0 0 0 0 0 0 0 0 6.45669 0 0 A0A8I3NKT6 A0A8I3NKT6_CANLF Uncharacterized protein LOC491803 Canis lupus familiaris (Dog) (Canis familiaris) DTQATTEEVN 1 2.9 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 8.48144 0 0 0 0 0 A0A8I3NKU0 A0A8I3NKU0_CANLF Cyclin I family member 2 CCNI2 Canis lupus familiaris (Dog) (Canis familiaris) FSRLLVSLKMR;RILQRVMIT;SHCKELVEQHLR 3 11 1.0038 -0.83431 9.1876 0 0 0 0 0 0 0 0 0 0 0 0 9.22429 0 A0A8I3NKU7 A0A8I3NKU7_CANLF Synaptic vesicle glycoprotein 2A SV2A Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836] neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] DEAWMVLKQ;GVEVFVVGFV;LKQVHDTNMRAK;QDEYSRRSYSRFEEEE;SEFLAQEKRGE;VMSCVSCFFLSFGNS 6 9.9 1.0022 -1.0144 0 0 0 0 0 6.93286 0 0 0 0 4.53593 10.0176 11.1292 0 0 A0A8I3NKU8 A0A8I3NKU8_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KA1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of DNA-templated transcription [GO:0045893] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] HVYLVTELMRGGELLDKILRQKFF;PLHSVVQQL;VAQPDDTFYF 3 6 1.0039 -1.054 0 0 9.93795 0 0 0 0 0 0 0 0 0 0 8.1818 0 A0A8I3NKV1 A0A8I3NKV1_CANLF Thioredoxin-interacting protein TXNIP Canis lupus familiaris (Dog) (Canis familiaris) cellular response to tumor cell [GO:0071228]; keratinocyte differentiation [GO:0030216]; negative regulation of cell division [GO:0051782]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; protein import into nucleus [GO:0006606]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737] enzyme inhibitor activity [GO:0004857]; ubiquitin protein ligase binding [GO:0031625] EFKFMPPPTYTEVDPSI;LVDVNTPDLMAPVSAKKEK;PDLMAPVSAKKEKKVSCM;SPIFMYAP;VLWMQGSQQCKQTSEYLRFEDTLLL 5 18.9 1.0023 -0.66051 0 0 0 4.65764 6.6605 0 0 0 0 0 0 0 11.9361 0 4.5767 A0A8I3NKV4 A0A8I3NKV4_CANLF WD repeat domain 81 WDR81 Canis lupus familiaris (Dog) (Canis familiaris) ENFRGTLT;EPVATFFQVFSQ;GAGKGKLA;GVVQLFDQPHPQR;KSASDPIHTFDLYGSEV;LESPEMLYVVHPYVQ;PVGAGKGK;SEEEEEDEEGCVVLEEEEG;SEEEEEDEEGCVVLEEEEGDG;YTIYVPFSCL 10 5.5 0.99662 -4.2975 0 11.5167 0 0 10.3234 6.24717 0 0 0 0 10.8528 9.06725 0 9.92631 0 A0A8I3NKW9 A0A8I3NKW9_CANLF Ring finger protein 103 RNF103 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] EACSCANKYC;KLFFLLLYFLVLFV;SVVHNSPGRASH;SYGSYNANEDMEPDWLTWPADML 4 13.3 1.0031 -0.79682 10.6527 3.86146 0 0 0 0 0 9.1758 0 0 0 0 0 0 0 A0A8I3NKY0 A0A8I3NKY0_CANLF Cell division cycle 5 like CDC5L Canis lupus familiaris (Dog) (Canis familiaris) "DNA damage checkpoint signaling [GO:0000077]; mRNA splicing, via spliceosome [GO:0000398]" cytoplasm [GO:0005737]; DNA replication factor A complex [GO:0005662]; nuclear speck [GO:0016607]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]" IQKKRKKKRG;TVGFGTNNSEHIAYLEHNPY 2 3.7 0.99449 -0.56242 0 0 0 0 0 0 0 0 7.8443 0 8.70977 0 0 0 5.83119 A0A8I3NKY9 A0A8I3NKY9_CANLF Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase GNE Canis lupus familiaris (Dog) (Canis familiaris) UDP-N-acetylglucosamine metabolic process [GO:0006047] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; N-acylmannosamine kinase activity [GO:0009384]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]" CSLIQTTPGTE;DEDLLLVEGMSVPKDE 2 3.8 0.98702 -0.35545 0 0 9.53089 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NKZ7 A0A8I3NKZ7_CANLF Triggering receptor expressed on myeloid cells 1 TREM1 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] plasma membrane [GO:0005886] KSPTQNLAQI;RNSLSNSYSLPTELQ 2 10.2 0.98968 -0.51768 0 0 0 0 9.92192 0 0 0 0 0 0 0 0 0 0 A0A8I3NL05 A0A8I3NL05_CANLF Zinc fingers and homeoboxes 2 ZHX2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; retinal bipolar neuron differentiation [GO:0060040]; somatic stem cell population maintenance [GO:0035019] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] EARKKMFN;LKASFLQS;NFTTKKYDSL;QVVEQDVPEEADRAKDKG 4 5.3 1.0024 -1.3907 0 0 0 0 0 0 10.6936 0 0 0 11.7101 0 9.5835 11.2995 0 A0A8I3NL14 A0A8I3NL14_CANLF Kinesin-like protein KIF2A Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule-based movement [GO:0007018] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] NSCRTSGQT;QEKREKRRLQQQELREKRAQDVDA;RPSQLPEQSSSA 3 6.4 0.9358 0.091743 0 0 4.21257 4.35389 0 0 6.97407 0 0 4.86938 7.86876 0 4.87931 0 4.51709 A0A8I3NL17 A0A8I3NL17_CANLF ADAM metallopeptidase domain 28 ADAM28 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AMCGKLFCQGGSEN;QGDQKYLIEPLSPTNDD;VGIVQDHSSNVLRVAGTMAH 3 6.7 0.98711 -0.38158 0 0 0 0 0 0 0 0 9.77605 8.12598 0 0 0 0 5.47784 A0A8I3NL21 A0A8I3NL21_CANLF Fc fragment of IgG receptor Ia FCGR1A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGEPLTLRCH;HKELQRKKKWNLEISLYSG;YFSFYMGSKTLL 3 12 1.003 -0.7819 0 0 0 9.71605 6.78947 0 0 0 0 0 0 0 0 0 10.6279 A0A8I3NL26 A0A8I3NL26_CANLF PNMA family member 1 PNMA1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730] AMTLLEDWCRGMDVNSQRALLVWGI;IQPLVESIWYK 2 10.2 0.98947 -0.51992 0 0 0 0 0 10.2238 0 0 0 0 0 10.1425 0 0 0 A0A8I3NL29 A0A8I3NL29_CANLF Adhesion G protein-coupled receptor E1 ADGRE1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] GIMTGEKKDG;SPGSYFCTCSLGFTP 2 3.4 0.99119 -0.54713 8.34207 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NL34 A0A8I3NL34_CANLF "ERCC excision repair 4, endonuclease catalytic subunit" ERCC4 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] DNA binding [GO:0003677]; nuclease activity [GO:0004518] EVEDLSLENAIGKP;EVGDYILT;REFRSELPSL;TKSLVQDLKILRTLL;YRKTFEKDSKAEEVWMKLRH;YYKRPVLLI 6 8.7 1.0001 -0.61553 0 11.8007 2.88559 0 0 0 9.62417 9.09247 10.964 9.97054 0 12.0839 0 0 0 A0A8I3NL36 A0A8I3NL36_CANLF palmitoyl-protein hydrolase (EC 3.1.2.22) LYPLA2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] carboxylic ester hydrolase activity [GO:0052689]; palmitoyl-(protein) hydrolase activity [GO:0008474] ADALSTIRLPHVKYICPHAPRI 1 15.9 0.97402 0.046925 0 0 0 6.86456 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NL44 A0A8I3NL44_CANLF Coiled-coil domain containing 15 CCDC15 Canis lupus familiaris (Dog) (Canis familiaris) DLQHRHQDQASIM;EEQKQLDLQDLQDI;ELKEQLRKKQEALKHFQR;NPLKSKDVLAVLAERNQAV;QAVEPEAQA;VINSCDMPEGTSALRV 6 11.4 0.98845 -0.50648 0 0 0 8.72431 0 0 11.4541 7.37825 0 0 0 0 7.91217 9.40077 0 A0A8I3NL50 A0A8I3NL50_CANLF Stabilizer of axonemal microtubules 4 SAXO4 Canis lupus familiaris (Dog) (Canis familiaris) LEWENAGH;TNQSYRPLEVPDGKYPLPWS 2 6.9 0.99233 -0.19201 0 0 0 0 0 6.33602 0 0 0 9.3987 0 0 0 0 0 A0A8I3NL52 A0A8I3NL52_CANLF Potassium channel tetramerization domain containing 19 KCTD19 Canis lupus familiaris (Dog) (Canis familiaris) male meiotic nuclear division [GO:0007140]; protein homooligomerization [GO:0051260] nucleus [GO:0005634] FPDSLLWKEASALSSLE;ITGFKDDRHTQER;IVNFLRSQKILLPDNF;LVREWDMVNCKQWEFQPVPVPQS;PLLDTEEEVHYCFLP;SALGQLRIESTLDGSRL;SDGSCMFFED 7 12 0.98864 -0.30823 0 7.59335 0 8.50601 8.95518 8.22308 9.83701 9.78795 7.65406 8.55163 0 0 0 0 0 A0A8I3NL72 A0A8I3NL72_CANLF non-specific protein-tyrosine kinase (EC 2.7.10.2) PTK2B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; regulation of biological quality [GO:0065008]; regulation of cellular component organization [GO:0051128]; regulation of multicellular organismal process [GO:0051239]; signal complex assembly [GO:0007172] cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] DLFFPKQMQENLKPKQ;PMLYMNDK;WLENKDVIGVLEKGDRLPKP 3 4.6 1.0027 -1.0048 6.14092 0 0 5.87534 0 0 0 0 0 0 5.92448 0 0 0 0 A0A8I3NL79 A0A8I3NL79_CANLF "RAB34, member RAS oncogene family" RAB34 Canis lupus familiaris (Dog) (Canis familiaris) AEGPRPGGAAPGSAKILLI;RPHLAAAESPRPRV;VGSPWPRVI 3 19.2 0.95345 0.049453 0 0 0 0 0 0 3.9442 0 0 0 0 0 0 0 0 A0A8I3NL86 A0A8I3NL86_CANLF Collagen type IX alpha 1 chain COL9A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen type IX trimer [GO:0005594]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803] AGEKGNTGAPGKPGQLGNSGKP;FCEPASCTMQAGQ;KGARGIDGEPGPQGIPG;NWSIWQIQDS;PGPPGVPGIDGIDGDRGPKGPPGPP 5 9.4 1.0021 -0.95614 7.68762 0 7.17662 0 0 5.48726 10.3258 0 0 0 0 0 0 0 0 A0A8I3NL90 A0A8I3NL90_CANLF Adenylate kinase 6 AK6 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] cytoplasm [GO:0005737]; nucleus [GO:0005634] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] LTGQLYDGYDEEYDCP 1 11.3 0.95655 0.049233 0 0 0 0 0 0 0 8.15962 0 0 0 0 0 0 0 A0A8I3NL91 A0A8I3NL91_CANLF Epsin 3 EPN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] AQALPSGKPSSPVELDLFGDP;GEQGRPTLN 2 4.9 0.99259 -0.27862 0 0 0 0 9.29841 0 0 0 0 0 0 0 0 0 0 A0A8I3NL96 A0A8I3NL96_CANLF GTP binding elongation factor GUF1 GUF1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of translation [GO:0045727]; translation [GO:0006412] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022] AGMYPIDQSEYNN;ITRKMKLLKR;LNEIVVDFYDSLK 3 5.9 0.98991 0.022402 0 0 0 0 0 0 0 0 0 10.8465 11.0893 0 10.707 0 0 A0A8I3NLB0 A0A8I3NLB0_CANLF Olfactory receptor OR52K1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVILAFYTPVVISSVMHRVAR;ISFYGCLVQMFFLHSFS;NPIIYGVKTKQ;VTLMTPLP 4 18.8 1.0027 -1.0104 0 0 9.96578 0 0 0 0 0 0 6.11749 9.36354 0 0 0 0 A0A8I3NLB3 A0A8I3NLB3_CANLF Hedgehog interacting protein HHIP Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EEMDGLSDFTGS;FLTLQQSPVSKQWQ;GARRRRCLN;RDRRLMSQLELLSGGEVLCGGFY;VEEISRKHKHN 5 11.8 0.99617 -0.5804 3.71655 0 0 0 0 7.28937 0 0 0 0 0 2.46921 0 0 0 A0A8I3NLB6 A0A8I3NLB6_CANLF Forkhead box P4 FOXP4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] ESERLQAMMAHLHMRPSE;GAAGAGGG;GPPEDRDLEEE;QQQQALMLQQLQEYYKKQQE;VEPLPSNGS 5 10.4 1.0012 -0.70519 0 0 0 10.6293 0 0 0 0 0 0 7.52716 0 0 0 0 A0A8I3NLB9 A0A8I3NLB9_CANLF Interleukin 17F IL17F Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription by RNA polymerase II [GO:0045944] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] FQVKSLLLLVLGLTLLS 1 8.7 0.9835 0.046227 5.45664 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NLC1 A0A8I3NLC1_CANLF Clathrin light chain CLTB Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] ciliary membrane [GO:0060170]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytosol [GO:0005829]; postsynaptic endocytic zone cytoplasmic component [GO:0099631]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802] clathrin heavy chain binding [GO:0032050]; structural molecule activity [GO:0005198] AASKVTEQEWREKAKKDLEEWNQRQ;ADKAFYQQP;QEPESIRKWRE 3 19.7 1.0028 -0.73319 0 7.00675 0 0 0 0 6.25488 0 0 0 0 0 9.98385 0 0 A0A8I3NLE3 A0A8I3NLE3_CANLF LBH domain containing 1 C18H11orf98 Canis lupus familiaris (Dog) (Canis familiaris) ELKKKLFKRRRVLNRERRLKHRVVG;KKLFKRRRVLNRERRLKHRVVG 2 19.2 0.94441 0.082237 0 0 0 0 0 0 0 0 4.68224 0 0 0 0 0 6.4165 A0A8I3NLE7 A0A8I3NLE7_CANLF Serine/threonine kinase 33 STK33 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GATKSTAK;LASAIAYLHSKDI;LDRKGHFSENETRWI;NLDAKCTASP;TCGTPIYMAPEV 5 12.3 1.0031 -1.7321 8.67716 0 0 8.58037 0 0 11.4371 0 10.5643 0 12.2765 0 0 9.08172 0 A0A8I3NLF0 A0A8I3NLF0_CANLF Uncharacterized protein DPPA5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] cytoplasm [GO:0005737] mRNA binding [GO:0003729] KWMLQSMAEWHRQRRERGML;LEDAMKALQLGPW;YGSYLYKLRAKWMLQ 3 37.1 0.98706 -0.50066 0 0 0 0 0 0 0 0 0 8.12944 0 0 0 0 7.12763 A0A8I3NLF4 A0A8I3NLF4_CANLF Uncharacterized protein FCN2 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] collagen trimer [GO:0005581]; extracellular region [GO:0005576] metal ion binding [GO:0046872] LSGWHTIYLPDCR;LSYHNTQPFS 2 7.1 0.98884 -0.20408 0 0 0 0 0 0 8.14547 0 0 8.75906 0 0 0 0 0 A0A8I3NLG5 A0A8I3NLG5_CANLF Protein Wnt WNT2 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] GAPQPKRGSSVFSAGR 1 5 0.96076 0.049233 0 0 4.54003 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NLH1 A0A8I3NLH1_CANLF 40S ribosomal protein S3a Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] QAAFQIPHNFNNDFLKI 1 15 0.98537 0.046227 0 0 0 0 0 0 0 0 8.90213 0 0 0 0 0 0 A0A8I3NLI6 A0A8I3NLI6_CANLF DDB1 and CUL4 associated factor 4 DCAF4 Canis lupus familiaris (Dog) (Canis familiaris) Cul4-RING E3 ubiquitin ligase complex [GO:0080008] TVNDVKVG 1 2.5 1.0048 -1.1044 8.3046 0 0 0 0 0 0 0 0 0 0 0 0 0 8.54156 A0A8I3NLI7 A0A8I3NLI7_CANLF Crumbs cell polarity complex component 2 CRB2 Canis lupus familiaris (Dog) (Canis familiaris) circulatory system development [GO:0072359]; establishment of cell polarity [GO:0030010]; ingression involved in gastrulation with mouth forming second [GO:0055111]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm formation [GO:0001707]; notochord formation [GO:0014028]; photoreceptor cell maintenance [GO:0045494]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; regulation of gastrulation [GO:0010470]; retinal cone cell development [GO:0046549]; somitogenesis [GO:0001756] apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cytoplasm [GO:0005737]; subapical complex [GO:0035003] aspartic-type endopeptidase inhibitor activity [GO:0019828]; calcium ion binding [GO:0005509]; protein-containing complex binding [GO:0044877] AALLLLPLLLAPALTL;ASRPLAALLLLPLLLAPALTLL;DGRFECRCSPGSA;GFEGDECGVDVDECASRPCLN;HGAFCGQNTT;LAALLLLPLLLAPAL;SPGSAGPGCRRPVLPEE 7 6.1 0.98848 -0.47291 0 0 0 0 0 0 0 0 0 0 10.9163 0 15.4676 0 0 A0A8I3NLJ5 A0A8I3NLJ5_CANLF 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) HMGCR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299] endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778] hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADP binding [GO:0050661] AAQNVGSSNCITL;AIYIACGQDAAQNVG;YLPYRDYNYSLLG 3 4.2 0.98672 -0.23314 0 9.15119 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NLK3 A0A8I3NLK3_CANLF Nuclear protein MDM1 MDM1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of centriole replication [GO:0046600] centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] microtubule binding [GO:0008017] NVDNGVGILTVFLFKTI;PKPEAPETELQEAEQK;PLLFSYLMSRIYIG 3 22 0.98908 -0.50702 0 0 0 8.17852 0 13.044 0 0 0 0 0 0 0 0 0 A0A8I3NLK4 A0A8I3NLK4_CANLF Cadherin 11 CDH11 Canis lupus familiaris (Dog) (Canis familiaris) corticospinal tract morphogenesis [GO:0021957]; focal adhesion assembly [GO:0048041]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of cell migration [GO:0030336] cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685] calcium ion binding [GO:0005509] FFTINPEDGFIKT;IVILLVIVVLFVTLRRQK;VVKLKKPV 3 4.9 0.99164 -0.14833 0 0 0 0 0 0 10.2182 10.1191 0 0 0 0 9.2105 0 0 A0A8I3NLK5 A0A8I3NLK5_CANLF Interleukin-1 IL1F10 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] LCGPAEPQQPVQ 1 6.8 0.98981 -0.20079 0 0 0 0 0 0 0 0 0 0 9.79557 0 0 0 0 A0A8I3NLN8 A0A8I3NLN8_CANLF Non-selective voltage-gated ion channel VDAC1 (Voltage-dependent anion-selective channel protein 1) VDAC1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] KTGYKREHINL;SNTRFGIAAKYQ;VIIFFLLGFGLIKLDL;VNLAWTAGNSNT 4 17.3 0.95632 0.049233 0 0 0 0 0 0 10.6727 0 0 0 0 0 0 0 0 A0A8I3NLP8 A0A8I3NLP8_CANLF Dynein axonemal heavy chain 8 DNAH8 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVIRQYNKISY;DLLDISNLPMWKP;EAKLTQVIENWTNQNLSF;FYPGVAEHKDISKL;GLNCLYLTFINAQIRHEVNSYRMP;HPGGGRNDIPQRLKRQFTVFN;IEEAYAIL;ILNTLIAQTTHDL;LDQYFEYIQ;LINDLFPGLQLDSSTYVELQ;LKGTESGEIITLMEDSL;LKNKDDIEDIC;LTGEQGTAKTVMVKAYMK;LVPSFDFLSEKLQFYQR;LVRRMLLLKLGVKITYIIKIELDS;PENLKIQFRT;PFRWILDMTWLNLVE;RCLGKYVV;SYLSFINGYKNIYTEKVKHINEQA;TDYEELNLLQK;TSLKFTNEPPQGI;VHVWDQETPIVLKKIQDCIFLFKEY;VPEQAKKLLKLESKLKA 23 9.4 0.98957 -0.53064 0 0 0 0 0 11.3278 0 0 0 0 0 0 0 0 0 A0A8I3NLP9 A0A8I3NLP9_CANLF Presenilin (EC 3.4.23.-) PSEN1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]; smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563] axon [GO:0030424]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; synapse [GO:0045202] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]" LTLLLLAIFKKAL;QNAQMSEDNHL;TIACFVAILIGLCLTLLLLAIFKK 3 9.1 0.99514 -0.15256 0 0 5.18876 0 0 11.7714 0 5.76331 0 0 0 0 0 0 0 A0A8I3NLQ0 A0A8I3NLQ0_CANLF SSD domain-containing protein PTCHD3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RAEKPEPQPEPEPQ;WQKTSAKD;YPAGTIGGT 3 7.2 0.98751 -0.48145 0 0 0 0 0 0 0 9.68038 0 0 0 0 0 0 0 A0A8I3NLQ4 A0A8I3NLQ4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] ESLDKTSKNVVTGLVGV 1 10.8 0.97853 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.75569 A0A8I3NLQ6 A0A8I3NLQ6_CANLF KLF transcription factor 15 KLF15 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle hypertrophy in response to stress [GO:0014898]; glial cell differentiation [GO:0010001]; intracellular glucose homeostasis [GO:0001678]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; podocyte differentiation [GO:0072112]; positive regulation of glucose import [GO:0046326]; regulation of Wnt signaling pathway [GO:0030111]; response to insulin [GO:0032868] nuclear speck [GO:0016607] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAEGQDSILDFLLSQATLGS;PLSEDDSDASSL;QPVQVKQESGME 3 10.6 0.99126 -0.19435 0 0 0 0 0 0 0 0 0 0 0 0 7.67235 0 6.6844 A0A8I3NLS5 A0A8I3NLS5_CANLF Receptor expression-enhancing protein REEP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789] microtubule binding [GO:0008017]; olfactory receptor binding [GO:0031849] ATAAVMAA;EDLLDFMYKY;YWIIFALFTTAETFTDIFLCWFPFY 3 11.9 0.98787 -0.49483 0 9.81137 0 0 0 0 12.9749 0 0 0 9.54038 0 12.4699 0 0 A0A8I3NLT2 A0A8I3NLT2_CANLF Apolipoprotein L3 LOC102156332 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576] lipid binding [GO:0008289] KVELEKRIRKLRRL;LGVAATVTHMSTSL;TKGIRFLGMASSGMFLLM;VSGIDQGDRVGL 4 17.4 0.9932 -0.061724 0 4.32833 0 0 0 0 0 10.6266 0 0 0 0 0 9.92865 0 A0A8I3NLT4 A0A8I3NLT4_CANLF Armadillo repeat containing 4 Canis lupus familiaris (Dog) (Canis familiaris) IALRSMKDFNL;KEKKKREKKKNEKKKREKKKRKKK;KKRKKKKGEKKKGVGEGNK;KRKKKKGEKKKGVG;NVVGALGECCQE;SKQRKREERKKERKEKEKKKREKKK;VFLNGGKTEDEGEI 7 8.8 0.99429 -0.026318 0 0 4.53618 0 0 0 9.56016 1.7442 7.00675 0 0 0 0 5.96571 0 A0A8I3NLT8 A0A8I3NLT8_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR150 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] membrane [GO:0016020] G protein-coupled peptide receptor activity [GO:0008528] AARGGGPG;APLPPRQAGAARA;PLLLLRQRLLAAPGPP 3 7.7 1.0012 -1.3158 0 0 0 0 0 0 0 13.2107 0 0 0 0 0 3.68605 0 A0A8I3NLU1 A0A8I3NLU1_CANLF FCH and double SH3 domains 2 FCHSD2 Canis lupus familiaris (Dog) (Canis familiaris) QNHRRPAEKIEDVE;VISPSSKPPGS 2 24.8 0.91622 0.11463 0 0 0 0 9.72011 9.83603 0 0 0 0 0 0 0 0 0 A0A8I3NLU3 A0A8I3NLU3_CANLF Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) CFAP36 Canis lupus familiaris (Dog) (Canis familiaris) ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737] NLSTLGTEELRQRERYLKQKRDK 1 6.7 0.97689 0.046431 0 8.3386 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NLV6 A0A8I3NLV6_CANLF "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] (EC 2.5.1.87)" DHDDS Canis lupus familiaris (Dog) (Canis familiaris) "transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]" ERDQAAVTEQL 1 3.7 0.98038 0.035491 0 0 0 0 0 8.87513 0 0 0 0 0 0 0 0 0 A0A8I3NLV9 A0A8I3NLV9_CANLF DNA mismatch repair protein MSH5 Canis lupus familiaris (Dog) (Canis familiaris) meiosis I [GO:0007127]; mismatch repair [GO:0006298] MutSalpha complex [GO:0032301] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] DWQVLYKTV;FIPYSMTTTEKILF;LHRLLGHIK;LLKFLGRR;LSRDPSEEQLPESKTDSSIRTGV;LVFFYQVCDGLAKA;LVSIDQDTYSVLQ 7 10.3 0.99932 -2.9221 0 0 0 0 0 0 0 9.49119 0 0 0 9.96867 0 3.81281 9.39528 A0A8I3NLW6 A0A8I3NLW6_CANLF Glutaredoxin and cysteine rich domain containing 1 GRXCR1 Canis lupus familiaris (Dog) (Canis familiaris) cochlea development [GO:0090102]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear receptor cell stereocilium organization [GO:0060122]; sensory perception of sound [GO:0007605]; vestibular receptor cell development [GO:0060118] kinocilium [GO:0060091]; stereocilium [GO:0032420] QPSGSLDSECASICGIDGLSE 1 7.2 0.98137 -0.24886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.3383 A0A8I3NLX5 A0A8I3NLX5_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DTVSVPAPASCPADGLVL;PLPPQREAGVGLQGG;VLSAGDQRDSQR 3 10.6 1.0015 -0.70758 0 0 0 0 0 10.4049 0 0 0 0 0 0 0 0 0 A0A8I3NLY2 A0A8I3NLY2_CANLF Uncharacterized protein LOC100685403 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCRDPCCCR;CCQPCCCRDPCCC;CCQPSCCQPCCC;CCQPSCCQPCCCRDPCCCRPV;CSSQGCGTECCQPSCCQ;ECCQPSCCQPCCCRDPCCCR;GCGTECCQPSCCQPCCCRD;GTECCQPSCCQPCCC;GTECCQPSCCQPCCCRDPCCCR;PCCCRPVSCQTTVCRPVT;PVCCDPCS;QGCGTECCQPSCCQPCCCRDPC;QPSCCQPCCC;SQGCGTECCQPSCCQPCCC 14 36.6 1.0033 -2.0922 4.73536 6.72288 6.77716 6.61212 0 2.2237 13.7553 7.12691 0 0 5.8003 0 6.47774 7.0607 4.89811 A0A8I3NLY5 A0A8I3NLY5_CANLF DDRGK domain-containing protein 1 DDRGK1 Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; negative regulation of gene expression [GO:0010629]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to endoplasmic reticulum [GO:0070972]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin-like protein ligase binding [GO:0044389] GVCGLGGA 1 2.1 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.8919 0 A0A8I3NLY7 A0A8I3NLY7_CANLF Parvin beta PARVB Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155] actin binding [GO:0003779] IDWINDVLVE;RMKKDESFLGK;SDLQEEGRHA;SDLQEEGRHAIN;SHVTEELTTTTE;VLVEERIIVKQL 6 14.5 0 2.0575 10.7641 8.93911 8.77673 9.07377 11.0181 10.8948 11.6351 11.1336 10.0541 11.3723 11.1923 11.1568 11.051 8.82979 10.741 A0A8I3NLY8 A0A8I3NLY8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VLNLRFSSKDFLSEQVL 1 5.2 0.98438 0.046227 0 0 0 0 0 0 8.24764 0 0 0 0 0 0 0 0 A0A8I3NLZ1 A0A8I3NLZ1_CANLF Suppressor of cytokine signaling 2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567] TPESSSLAVLVFAAPQAF 1 10.1 0.95811 0.051098 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.67948 A0A8I3NLZ6 A0A8I3NLZ6_CANLF Olfactory receptor OR2AT2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LDFHIMGNV;VFLFLYLLILLGNVLILLAVV 2 9.6 0.97536 0.047166 0 0 0 0 0 0 5.53928 0 0 0 0 0 0 0 0 A0A8I3NM03 A0A8I3NM03_CANLF Calreticulin CALR Canis lupus familiaris (Dog) (Canis familiaris) cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of meiotic nuclear division [GO:0040020] cortical granule [GO:0060473]; cytosol [GO:0005829]; endoplasmic reticulum quality control compartment [GO:0044322]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; MHC class I peptide loading complex [GO:0042824]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; sarcoplasmic reticulum lumen [GO:0033018] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; integrin binding [GO:0005178]; molecular sequestering activity [GO:0140313]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082] EDEEDEDDKEEEEEDDAAAGQA;EDKDEDEEDEDD;PEIDNPEYSPDSNI;SLEDDWDFLPPK 4 12.5 0.98626 -0.45528 3.88176 0 8.83693 0 5.85045 0 0 0 0 0 0 0 0 0 0 A0A8I3NM08 A0A8I3NM08_CANLF BTB domain containing 2 BTBD2 Canis lupus familiaris (Dog) (Canis familiaris) neurogenesis [GO:0022008] cytosol [GO:0005829]; P-body [GO:0000932] GPPPAPVPGPGPGPGPGP;LPVTPENKRKVLGKALALIRFP 2 8.2 0.98411 -0.24277 0 0 0 0 0 0 0 0 0 0 0 0 9.85345 0 0 A0A8I3NM16 A0A8I3NM16_CANLF Retinoic acid receptor RXR (Nuclear receptor subfamily 2 group B member) RXRA Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; zinc ion binding [GO:0008270] AIVLFNPDSKG;KSPGSHFLCTDFSTQ 2 4.7 0.99448 -0.11761 0 0 0 0 0 0 0 0 0 10.3628 0 0 0 0 0 A0A8I3NM22 A0A8I3NM22_CANLF Glutathione peroxidase GPX4 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; chromatin organization [GO:0006325]; lipoxygenase pathway [GO:0019372]; negative regulation of ferroptosis [GO:0110076]; protein polymerization [GO:0051258]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; protein-containing complex [GO:0032991] glutathione peroxidase activity [GO:0004602]; identical protein binding [GO:0042802]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066] NVKFDMYSKI 1 5.1 0.99986 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 8.49053 0 0 A0A8I3NM24 A0A8I3NM24_CANLF Transmembrane protein 165 TMEM165 Canis lupus familiaris (Dog) (Canis familiaris) Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751] cis-Golgi network membrane [GO:0033106]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] calcium ion transmembrane transporter activity [GO:0015085]; manganese ion transmembrane transporter activity [GO:0005384] AAPDGDLSHRNK;EGLKMSPDEGQEELEE;ERRRRRVRGARRRRLRRPHFLLRH;RLPLLLLLALLWA;TGASTAIPQKRWLHFISPIFV;VAVAAGGM 6 21.1 1.0019 -1.2085 0 14.5742 0 0 0 4.69694 11.0017 0 0 0 9.93032 5.4834 0 0 0 A0A8I3NM36 A0A8I3NM36_CANLF Growth factor receptor bound protein 14 GRB14 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of insulin receptor signaling pathway [GO:0046627]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971] AARGRGDARGPAPAPWGP;DETSRALEVPS;VSLAGKKK 3 6.9 1.0036 -0.80415 0 0 0 0 9.99421 0 0 0 0 0 0 0 0 0 0 A0A8I3NM45 A0A8I3NM45_CANLF "PWWP domain containing 3A, DNA repair factor" PWWP3A Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA repair [GO:0006281] cytosol [GO:0005829]; nucleoplasm [GO:0005654] nucleosome binding [GO:0031491] FDCKEKQELLNEA;FNPIHSILEEDEDDEE;LVWLKHQKYPFWPA;QGEVPAEP;QQDVLGTRFPQLSKEDPE;SLGYREKEIFDKQ 6 11.9 1.0031 -0.83915 0 0 0 6.26228 0 0 7.73532 0 9.2471 0 0 0 0 11.6978 0 A0A8I3NM49 A0A8I3NM49_CANLF Arginine/serine-rich protein 1 RSRP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AYALPQGRRYYGFG 1 6.1 0.94176 0.0611 0 0 0 0 0 0 0 10.2854 0 0 0 0 0 0 0 A0A8I3NM51 A0A8I3NM51_CANLF Mbt domain containing 1 MBTD1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] ARLQGKPPTKKAKVLQK;CSRSYSSN 2 3.8 0.97696 0.046227 0 0 0 0 0 0 0 0 0 5.17017 0 0 4.7365 0 0 A0A8I3NM52 A0A8I3NM52_CANLF Synembryn (Protein Ric-8) RIC8B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085] LEEALSQYSVI;LGVKQIAAEFLFV;NWYSEDEDTDTEEYKNAK;QVSCLEVLRILSRDKKILVPV 4 12.1 0.99339 -0.27901 0 3.1429 0 0 0 0 0 0 0 10.5538 11.1326 0 0 0 10.5167 A0A8I3NM53 A0A8I3NM53_CANLF Squalene monooxygenase (EC 1.14.14.17) SQLE Canis lupus familiaris (Dog) (Canis familiaris) sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789] flavin adenine dinucleotide binding [GO:0050660]; squalene monooxygenase activity [GO:0004506] KFRKNLISN;SEVQIPYPVSE 2 4.2 0.99111 -0.54719 0 0 9.06821 0 0 0 0 0 0 11.3783 0 0 0 10.4867 0 A0A8I3NM69 A0A8I3NM69_CANLF 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) ALDH1L1 Canis lupus familiaris (Dog) (Canis familiaris) 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; one-carbon metabolic process [GO:0006730] cytoplasm [GO:0005737] "formyltetrahydrofolate dehydrogenase activity [GO:0016155]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AGTVFVNTYNKTD;CQHGVEEG;EDHMFIAKEES;LPRPRLRRLAWPATPRL 4 5.7 0.97724 0.046227 0 0 0 0 0 6.93062 0 0 0 0 0 0 0 0 0 A0A8I3NM70 A0A8I3NM70_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SQPRPGTAPNY 1 2.6 0.98494 -0.2387 0 9.26711 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NM73 A0A8I3NM73_CANLF Uncharacterized protein ZNF713 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] NPYKYECGKIFNQHIL 1 3.6 0.96157 0.049233 0 0 0 0 0 0 0 0 0 0 5.08793 0 0 0 0 A0A8I3NM75 A0A8I3NM75_CANLF Endonuclease V ENDOV Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] cytoplasm [GO:0005737]; nucleolus [GO:0005730] "DNA binding [GO:0003677]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; RNA endonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; single-stranded RNA binding [GO:0003727]" AKKLLQVDGLEN;LVDAVQRLQEKEPHMVP 2 10 0.98823 -0.49081 0 8.0536 0 0 0 0 8.66445 0 10.6357 0 0 0 9.15737 0 0 A0A8I3NM77 A0A8I3NM77_CANLF Bleomycin hydrolase (EC 3.4.22.40) BLMH Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type aminopeptidase activity [GO:0070005] EDHGHKERIYCFHL;GVVPKKCF;LVQYLLMNPANDGGQ;VVCICLGNPPETFTWEYR 4 13.1 1.0013 -0.94122 7.63641 10.5697 0 8.43717 0 0 0 0 0 0 0 4.99227 0 0 0 A0A8I3NM78 A0A8I3NM78_CANLF "Protein MTO1 homolog, mitochondrial" MTO1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] flavin adenine dinucleotide binding [GO:0050660] GCVSQQRYERA 1 1.6 0.98946 -0.19887 0 0 0 0 0 0 0 0 0 10.1311 0 0 0 0 0 A0A8I3NM81 A0A8I3NM81_CANLF Archaelysin family metallopeptidase 1 AMZ1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallopeptidase activity [GO:0008237] DGLGSLAIPESP;HEVGVCSF;LGLTLSDLYPCEAWSFTF 3 7.6 1.0024 -1.3603 2.83497 0 0 0 10.3061 0 0 0 0 11.1102 0 0 0 6.87578 0 A0A8I3NM93 A0A8I3NM93_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase 7 ENPP7 Canis lupus familiaris (Dog) (Canis familiaris) GRLAVLLVLALAALLAPGAGAPV;LHYARNPRITP;LVSFDGFRWNYDQDVH;VEFHKFPNFTFKDI;VEWKANIDTVMKWFT;WNYDQDVHTPNLDAM 6 18.4 0.97831 0.046253 0 0 0 0 0 0 6.74403 0 0 0 0 0 0 0 0 A0A8I3NMA0 A0A8I3NMA0_CANLF NPC1 like intracellular cholesterol transporter 1 NPC1L1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol transport [GO:0030301] membrane [GO:0016020] lipid transporter activity [GO:0005319] AFHDQHFGPFLR;AFLEEMKAFQ;FALISGFA;GKDKTPDPKAGMSL;SAFVALLSLDSRRQEASR;VFPYTITNVFYEQYLSV;VLLHRVTR;YHYDSLLLGPKNF 8 7.8 1.0033 -2.1039 14.6152 0 14.6278 0 0 0 0 10.7784 3.56401 0 9.56249 13.8247 0 10.9072 0 A0A8I3NMA6 A0A8I3NMA6_CANLF DENN domain containing 5A DENND5A Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; retromer complex [GO:0030904]; trans-Golgi network [GO:0005802] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] ENVEWNPFDQD;GGGGGGGG;GVYGPIICQ;LDAPVPYLMG;PEDLPQFPNKLEFVQEVS;QIGHDNSGLYAKWLVEY;TTVQIGHDNSGLY;VENVFQLFTCALLEFQ;VLEQLHQAVTSPQP 9 8.2 1.0043 -2.0018 8.6674 10.3229 0 8.84301 7.9567 0 0 0 0 0 0 8.23549 9.35678 9.95337 0 A0A8I3NMB0 A0A8I3NMB0_CANLF Erythrocyte membrane protein band 4.1 like 4B EPB41L4B Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte migration [GO:0051549]; wound healing [GO:0042060] apical part of cell [GO:0045177]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092] ATPLAEPA;GARLRRTSTFERKPSKRYPSR;IVYHLDLVETDYFGLQFLDSSQV;NIHPSQPRWHPHSPNVSFPLPSPG;WHPHSPNVSFPLPSPGLSSSDRLP 5 9.4 1.002 -1.2477 0 0 10.367 0 0 9.35548 0 0 9.25908 6.9521 0 0 0 0 0 A0A8I3NMB1 A0A8I3NMB1_CANLF Uncharacterized protein GLT6D1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758] FTIREDSREDFHLMHMKNLASHI;PDVVTTTDWLAP;PDVVTTTDWLAPV;QEEMHSKRKMLLLIS;YHFRDEVEL 5 15.1 1.0023 -0.95568 7.6799 0 9.09577 0 9.97656 0 0 0 0 9.99944 0 0 0 11.9383 0 A0A8I3NMB7 A0A8I3NMB7_CANLF Dynactin subunit 6 DCTN6 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] dynactin complex [GO:0005869]; membrane [GO:0016020] dynein complex binding [GO:0070840] MAEKAQKSVKIAPG;QTLQLDFLM;VGYNGVVMMCAGLGCACFN 3 11.8 0.95234 0.049546 0 7.76447 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NMC2 A0A8I3NMC2_CANLF Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) EZH2 Canis lupus familiaris (Dog) (Canis familiaris) B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to trichostatin A [GO:0035984]; cerebellar cortex development [GO:0021695]; facultative heterochromatin formation [GO:0140718]; G1 to G0 transition [GO:0070314]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte homeostasis [GO:0036333]; keratinocyte differentiation [GO:0030216]; liver regeneration [GO:0097421]; methylation [GO:0032259]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of striated muscle cell differentiation [GO:0051154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; protein localization to chromatin [GO:0071168]; regulation of circadian rhythm [GO:0042752]; regulation of gliogenesis [GO:0014013]; regulation of protein phosphorylation [GO:0001932]; response to tetrachloromethane [GO:1904772]; rhythmic process [GO:0048511]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; stem cell differentiation [GO:0048863]; subtelomeric heterochromatin formation [GO:0031509] "chromatin silencing complex [GO:0005677]; chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; pericentric heterochromatin [GO:0005721]; pronucleus [GO:0045120]" chromatin DNA binding [GO:0031490]; histone H3K27 methyltransferase activity [GO:0046976]; lncRNA binding [GO:0106222]; primary miRNA binding [GO:0070878]; promoter-specific chromatin binding [GO:1990841]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] CQCSSECQN;DDDDDDDGDDPD;DDDDGDDP;EEEKKDETSSSSE;KKRKHRLWAAHCRKIQLKK;LNNDFVVDATRKGNK;LVNALGQYNDDDDDDDGDDP;NDDDDDDD;NDDDDDDDGDDPDEREEK;NFCEKFCQCSSEC;PPRKKKRKHRLWAAHCRKIQ;SFHATPNTY;SVQREQSLHSFH 13 15 1.0033 -2.0994 0 7.17702 9.76369 0 0 3.08313 11.9084 0 0 0 0 0 10.188 0 9.8799 A0A8I3NMD1 A0A8I3NMD1_CANLF Mitochondrial ribosomal protein S2 MRPS2 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] small ribosomal subunit [GO:0015935] structural constituent of ribosome [GO:0003735] APGPGLVRAAGP;RRGPGDRGG 2 4 0.99103 -0.22151 0 0 10.6041 0 0 0 0 0 0 0 0 8.70826 0 9.739 0 A0A8I3NMD7 A0A8I3NMD7_CANLF Zinc finger protein 189 ZNF189 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EIEEEVEPQGV;LDVLNRDKD;LVSLDVLNRDK;QETHECEACGEAFNC 4 6.1 0.99668 -0.57852 0 0 0 0 0 0 0 8.97985 0 7.15805 0 7.4297 9.96529 0 0 A0A8I3NME8 A0A8I3NME8_CANLF Hydroxysteroid 17-beta dehydrogenase 11 HSD17B11 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" LLKLFIPKKRKSVTG;LPLLIIFTLESLLKLFIPKKRKS;TVASVCGHGV 3 12 1 -0.61146 0 0 9.21247 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NMF3 A0A8I3NMF3_CANLF Acidic nuclear phosphoprotein 32 family member E ANP32E Canis lupus familiaris (Dog) (Canis familiaris) APDSEEEDDEDGDEDDEEEEDE;DDEDGDEDDEEEEDEA;DEDGDEDDEEEED;EAPDSEEEDDEDGDEDDEEE;EDEDEAGS;EDEDEDEAGSELGEGEEEVGL;EEDDDDYV;EEDNEAPDSEEEDDEDG;EEEEEEEEEDEDEDEDEAGS;GDEDDEEEEDEAGPPEEYEEEEEEE;IQDEEDDDDYVEEGEEEEEEEEE;PDSEEEDDEDGDEDDE;PDSEEEDDEDGDEDDEEEEDEA;QDEEDDDDYVEEGEEE;SEEEDDEDGDEDDEEEEDEAGPPEE 15 66.7 0.9804 0.046227 0 0 0 0 0 0 8.25526 0 0 0 0 0 0 0 0 A0A8I3NMF4 A0A8I3NMF4_CANLF Uncharacterized protein LOC119863875 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] KLELFLPEEYPMAAPKVRFITKIY;PDESNARYFHVVIA 2 25 0.97051 0.041303 0 0 0 0 0 0 8.60903 0 0 0 0 0 0 0 0 A0A8I3NMG1 A0A8I3NMG1_CANLF Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11) SLC38A11 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] membrane [GO:0016020] ITNPQDCTHGQEMFYCFPDNFSL;VDPENLFIGRHF 2 9.1 0.93426 0.096693 0 0 0 0 0 0 0 5.01449 0 0 5.03435 0 0 0 9.19623 A0A8I3NMG3 A0A8I3NMG3_CANLF 14-3-3 protein epsilon YWHAE Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346]; signal transduction [GO:0007165] cytoplasm [GO:0005737] phosphoserine residue binding [GO:0050815] AEQAERYDEMVESMK;GDYHRYLAE 2 9.4 0.79265 0.22277 0 0 0 0 0 0 0 0 0 10.8737 0 0 0 0 0 A0A8I3NMG4 A0A8I3NMG4_CANLF Tubulin folding cofactor E like TBCEL Canis lupus familiaris (Dog) (Canis familiaris) HVSELDLSDNKLEDWHEVSKI;LVLNNSKASWETVHTILQELP;VLNSCGITRAGDEKEI;VLVLNSCGITRAGDEKEIA 4 14.4 1.0011 -0.62741 0 0 0 0 10.9917 0 9.74389 0 0 0 0 0 0 0 0 A0A8I3NMG5 A0A8I3NMG5_CANLF Zinc finger protein 436 ZNF436 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EDMAMYLT;FSRSSHLAQHQR 2 4.3 0.99235 -0.17805 0 0 9.48593 8.6708 9.7198 9.05284 0 0 0 0 0 10.6446 0 0 8.06743 A0A8I3NMG8 A0A8I3NMG8_CANLF Cadherin domain-containing protein MRPL17 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AADGPSSP;ADGKPCVAGALTAIVAGEEEL;APGAHTRWFSI;GSAFVTVN;GVSGAWGQ;IVQARNPPG;LAGGGGAF;NDNAPRFLRPHYV;PASTAATRAIFPPA;PGGGGGGG;PSPPPSEHLYHQT;QLLAHDGPHEG;SAQSTPGTAVLRVRAHDP;YSIVSGNRGR 14 4.5 0.99673 -5.2138 0 8.54998 0 0 6.81263 0 0 9.90811 7.49729 8.56815 6.50632 5.17173 9.52078 9.88795 11.1995 A0A8I3NMJ0 A0A8I3NMJ0_CANLF Immunoglobulin kappa variable 4-1 IGKV4-1 Canis lupus familiaris (Dog) (Canis familiaris) GVSGEIVMTQSP;LAWYQQKPGER;QKNYLAWYQ 3 16.4 0.98785 -0.48385 0 0 0 0 0 0 11.5513 0 0 0 0 0 6.90268 0 0 A0A8I3NMK2 A0A8I3NMK2_CANLF Vitelline membrane outer layer 1 homolog VMO1 Canis lupus familiaris (Dog) (Canis familiaris) AKLLLLVLL 1 4.5 1.0035 -0.80421 0 8.24089 0 0 0 0 0 0 0 0 8.80951 0 0 0 0 A0A8I3NMK7 A0A8I3NMK7_CANLF Zinc finger protein 668 ZNF668 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EHVECQDAGV;GPADCAEEVADAML;VGMTVEHVECQDAGV 3 4.7 1.0011 -0.64367 2.58195 0 0 0 0 0 0 0 0 0 9.02359 0 9.28868 0 0 A0A8I3NMN2 A0A8I3NMN2_CANLF [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) KDM4B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; zinc ion binding [GO:0008270] ATPAPDTCPASGECCR;ATQCTCRK;LKAKLLRRSHRKRSQ 3 3 0.98689 -0.40884 0 0 0 0 0 0 5.42257 0 0 0 0 0 5.62141 0 0 A0A8I3NMN3 A0A8I3NMN3_CANLF Uncharacterized protein ZNF12 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEKPYECNQCGKSFCQ 1 2.3 0.93777 0.063034 0 0 0 0 0 0 13.5238 0 0 12.9167 0 0 13.0837 0 0 A0A8I3NMP7 A0A8I3NMP7_CANLF Rho GTPase activating protein 8 ARHGAP8 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FNSLSELREHLKYDQ;HAEGLFRRSASVH;KTFLRELPQPL;PLPGRGQV 4 8.2 1.0029 -1.9093 0 10.2057 0 9.8855 0 0 9.83944 0 0 0 0 0 0 0 0 A0A8I3NMR0 A0A8I3NMR0_CANLF SET domain without mariner transposase fusion SETMAR Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K9 methyltransferase activity [GO:0046974]; zinc ion binding [GO:0008270] FECNVLCQCSDH;PGTCSCLRHGENYDDNSCLI 2 9.4 0.93161 0.098646 10.4607 5.33364 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NMR2 A0A8I3NMR2_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member ANP32E Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone binding [GO:0042393]; phosphatase inhibitor activity [GO:0019212] APEEVTELVL;EEDDDDYV;LDEEDDDDYVEEGE 3 16.1 0.93141 0.060769 0 0 0 0 0 0 9.79844 0 0 0 0 0 0 0 0 A0A8I3NMR5 A0A8I3NMR5_CANLF Nuclear pore complex protein NUP107 Canis lupus familiaris (Dog) (Canis familiaris) female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; protein transport [GO:0015031] kinetochore [GO:0000776]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore outer ring [GO:0031080] structural constituent of nuclear pore [GO:0017056] ETFNEWFKHMNSAPQKPTL;IDVIDWLVFD;LIAFYTCHLPQ;NAIREHLCIRAYLEANETFNEWF;NLDETEELP;SAQKRVLIR;VLIRPSQDE;WTLEKVFEELQATDK 8 10.2 1.0035 -2.2092 11.3703 0 0 8.69777 6.99084 0 7.4645 0 0 0 0 9.28432 0 0 0 A0A8I3NMT1 A0A8I3NMT1_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD4 Canis lupus familiaris (Dog) (Canis familiaris) DNA alkylation repair [GO:0006307]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein deubiquitination [GO:0016579]; regulation of protein K48-linked deubiquitination [GO:1903093] cytosol [GO:0005829] cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090] DLSKECVSVSAVD;GVDRGGAG;GVRQHTFSSH;LRENREKFEAFIE;PHVWYGYPFQGF;QQKRDYSIAAGLQYEVGD;TTGPDSAV 7 7.4 1.0023 -1.8427 6.47544 7.43521 0 9.00104 8.92071 0 0 11.635 0 0 0 0 0 0 0 A0A8I3NMU3 A0A8I3NMU3_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member ANP32E Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone binding [GO:0042393]; phosphatase inhibitor activity [GO:0019212] APEEVTELVL;KRRKKRRMRMRMRMKRARNWEREKR;VHLKNMKKKRRKK;VHLKNMKKKRRKKR;VHLKNMKKKRRKKRR 5 26.7 0.79612 0.20974 0 0 0 2.72478 0 4.66795 0 0 0 0 0 0 0 0 6.7494 A0A8I3NMU7 A0A8I3NMU7_CANLF Nuclear receptor binding SET domain protein 3 NSD3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; N-methyltransferase activity [GO:0008170]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] ECLSIEMPEGCWNCNDC;ISDSCKPL;KRRKIKAEPKQ;PPPYKHIKANK;RLRIKRAHENSVT;VSEKPREEPVPK;WECPWHQCEEC 7 6 0.93838 0.059718 0 0 0 0 0 6.63096 0 0 0 0 0 0 0 0 0 A0A8I3NMV1 A0A8I3NMV1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM32 Canis lupus familiaris (Dog) (Canis familiaris) actin ubiquitination [GO:0007014]; axon development [GO:0061564]; fat cell differentiation [GO:0045444]; free ubiquitin chain polymerization [GO:0010994]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of cilium assembly [GO:1902018]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein K48-linked ubiquitination [GO:0070936]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; suppression of viral release by host [GO:0044790]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863] identical protein binding [GO:0042802]; myosin binding [GO:0017022]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DLPNLTPLSVAMN;FCSKITRI;SKDLQARYKAVLQEYGHEERRVQEE 3 7 1.0019 -0.74136 0 11.6152 0 0 0 0 0 6.73552 0 0 0 0 0 8.49969 0 A0A8I3NMV3 A0A8I3NMV3_CANLF Retinal outer segment membrane protein 1 ROM1 Canis lupus familiaris (Dog) (Canis familiaris) camera-type eye photoreceptor cell differentiation [GO:0060219]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell outer segment organization [GO:0035845]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein localization to photoreceptor outer segment [GO:1903546]; regulation of gene expression [GO:0010468]; retina vasculature development in camera-type eye [GO:0061298] photoreceptor outer segment membrane [GO:0042622] protein homodimerization activity [GO:0042803] AEEAPPKEGLPE;GVIDGEGEAQGYLFP;SLASTLGSTLTVTFMLQILVLL 3 14 0.99324 -0.1608 0 10.3069 0 0 0 0 0 0 0 0 0 0 0 9.85908 0 A0A8I3NMW0 A0A8I3NMW0_CANLF tRNA nucleotidyl transferase 1 TRNT1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA 3'-terminal CCA addition [GO:0001680] nucleotide binding [GO:0000166]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723] DLKNKKVRF;EKHGTITARLHEENFE;GAVRDLLNGV;HDPETLEAIAEN 4 11.6 1.0038 -1.0371 0 0 0 0 0 0 10.2068 0 14.5874 0 0 0 0 14.1694 0 A0A8I3NMW6 A0A8I3NMW6_CANLF Nucleolar protein with MIF4G domain 1 NOM1 Canis lupus familiaris (Dog) (Canis familiaris) hair follicle maturation [GO:0048820] nucleolus [GO:0005730] RNA binding [GO:0003723] DIELTLLMLKN;GKNNGLYESSSSGEE;PVGGCGGG;VGSAWSGA;VGVEVGAHFLEAV;YNPFYALLAGK 6 7.6 1.002 -1.4619 0 6.5343 0 0 9.51057 0 0 0 11.4556 10.6044 10.8025 7.78614 0 0 8.16022 A0A8I3NMX6 A0A8I3NMX6_CANLF Uncharacterized protein KRT34 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] LTETEARYGSQLAQV;VGNCGWFC 2 6.3 0.98678 -0.45798 0 8.36833 0 0 9.46412 0 0 0 0 0 0 0 0 0 0 A0A8I3NMY6 A0A8I3NMY6_CANLF FAM193 C-terminal domain-containing protein FAM193B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] CSGHCGGP;ESLELCIL;SLLVESLELCILVSN;SSSSSCHG 4 3.3 1.003 -2.4208 0 5.66129 6.93605 8.88686 0 0 4.74475 0 7.57645 0 0 0 8.10967 8.46732 7.5744 A0A8I3NMY9 A0A8I3NMY9_CANLF Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to nicotine [GO:0035095]; locomotory behavior [GO:0007626]; neuronal action potential [GO:0019228]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of smooth muscle contraction [GO:0006940]; smooth muscle contraction [GO:0006939]; synaptic transmission involved in micturition [GO:0060084] cholinergic synapse [GO:0098981]; postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] FRWDVQEALEGVSFIARHMQSD;IVCSHVPS;NLIIPCLLITSLA;RRCFLHKLPT;VLLALTVFLLLISKIVPPTSLDV 5 14.6 1.003 -0.73221 9.39283 0 11.6104 0 0 3.83764 0 0 10.7349 9.56685 0 10.0396 11.2477 11.4668 0 A0A8I3NN20 A0A8I3NN20_CANLF Cyclin-dependent kinase 5 activator CDK5R1 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; cerebellum development [GO:0021549]; ephrin receptor signaling pathway [GO:0048013]; G1 to G0 transition involved in cell differentiation [GO:0070315]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron migration [GO:0001764]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of microtubule cytoskeleton organization [GO:0070507]; rhythmic process [GO:0048511]; superior olivary nucleus maturation [GO:0021722] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein kinase 5 complex [GO:0016533] actin filament binding [GO:0051015]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020]; protein kinase binding [GO:0019901] DGAATVGH 1 2.6 1.0041 -1.1044 0 0 0 0 0 0 9.30467 0 0 0 0 0 0 0 0 A0A8I3NN23 A0A8I3NN23_CANLF L3MBTL histone methyl-lysine binding protein 1 L3MBTL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] zinc ion binding [GO:0008270] DEGRLVTVTHVSGKNLVWTVAQLAN;EDQARLFKDEGRLVT;LEAVDRMN;PEEDGTCQCQECGPQ;RFRISEYAPLNMVGAEQ;VGAEQPPSP;VGAEQPPSPELRPE 7 9.6 0.99625 -0.58537 9.75541 0 9.52125 0 0 6.97774 9.54763 0 5.85507 0 0 0 0 9.32465 0 A0A8I3NN30 A0A8I3NN30_CANLF Scratch family transcriptional repressor 2 SCRT2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neuron migration [GO:2001222] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SAFKHYRCRQCDKSFALKSYLHK 1 7.5 0.97963 0.046263 0 0 8.60944 0 0 0 0 0 0 0 0 0 8.82903 0 0 A0A8I3NN31 A0A8I3NN31_CANLF Kinesin-like protein KIF5A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EVKSVVKRCRQLE;SFLENNLE;TKTNLSVHEDKNR;VNDNSSIVVRIAPEERQKYEE 4 5.8 0.984 -0.24289 13.9676 0 0 0 11.7098 0 0 9.6619 10.6003 0 12.3225 0 13.874 0 0 A0A8I3NN42 A0A8I3NN42_CANLF RNA exonuclease 1 homolog REXO1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] LTTLFPGQKRRIS;LVPSSVPG;PAPPRLSSDSDSDSDSDSD;QLKENGYPFPHPERPG;TGAKRTLAAS;VDYNTRFSGVT;YKRSLRNLM 7 7.2 1.003 -2.1101 5.92236 0 0 0 8.53667 0 8.8108 0 0 0 0 6.43316 0 0 5.5191 A0A8I3NN43 A0A8I3NN43_CANLF Sialidase-1 (EC 3.2.1.18) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) NEU1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; oligosaccharide catabolic process [GO:0009313] cell junction [GO:0030054]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765] exo-alpha-sialidase activity [GO:0004308] PGKLRTTLTFP 1 2.1 0.98677 0.035491 0 0 8.34589 0 0 7.9589 0 0 0 0 7.13093 0 0 0 0 A0A8I3NN46 A0A8I3NN46_CANLF A-type potassium channel modulatory protein DPP6 (Dipeptidyl aminopeptidase-like protein 6) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase VI) DPP6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508]; regulation of potassium ion transmembrane transport [GO:1901379] voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; serine-type peptidase activity [GO:0008236] GGGGGGGA;GGGGGGGG;HYFNSASLHQHLYRSIINFF;NTVGNFNRQCL;PLAAPAPAAA;RLAYATIN;WLYEEEILKTHIAHWWSP;YFLSTEDLPRRRQLYSANTVGNFN 8 10.9 1.0027 -1.3418 0 9.79266 12.0708 0 0 0 0 11.4821 0 0 0 0 12.8194 0 0 A0A8I3NN77 A0A8I3NN77_CANLF Septin SEPTIN1 Canis lupus familiaris (Dog) (Canis familiaris) meiotic metaphase chromosome alignment [GO:0051311]; spindle assembly involved in female meiosis [GO:0007056] meiotic spindle [GO:0072687]; midbody [GO:0030496]; septin complex [GO:0031105] GTP binding [GO:0005525]; identical protein binding [GO:0042802] DESGLNRKNIQDSRVHC;DTPGFGDSVDCSDCWL;FPDCDSDEDE 3 11.7 0.98498 -0.23695 0 0 0 0 0 6.60127 0 0 0 0 0 0 0 0 0 A0A8I3NN82 A0A8I3NN82_CANLF Cation channel sperm associated 4 CATSPER4 Canis lupus familiaris (Dog) (Canis familiaris) establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] calcium-activated cation channel activity [GO:0005227]; voltage-gated calcium channel activity [GO:0005245] EVEDGRNELPLVHCV;LVFSVFGVTLFGAF;VSREVEDGRNELPLV 3 7.5 0.99273 -0.042883 0 0 0 9.45261 0 8.81944 0 0 0 0 0 0 9.65363 0 11.0244 A0A8I3NN85 A0A8I3NN85_CANLF Casein kinase I isoform gamma-3 (EC 2.7.11.1) CSNK1G3 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DRKGYLFDYEYDW 1 3.4 0.94046 0.059561 0 0 0 0 0 0 0 0 0 4.68891 0 0 0 0 0 A0A8I3NN90 A0A8I3NN90_CANLF Neurogenic differentiation factor NEUROD4 Canis lupus familiaris (Dog) (Canis familiaris) amacrine cell differentiation [GO:0035881]; cell fate commitment [GO:0045165]; motor neuron migration [GO:0097475]; neuroblast proliferation [GO:0007405]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell differentiation [GO:0045597]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] PDLDKSYSFMPHYSSA;VHNFNYQSPGLPSPP;YSSANLSSG 3 10.9 0.98817 -0.34536 8.47569 0 0 9.14614 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NN99 A0A8I3NN99_CANLF Large ribosomal subunit protein uL4 (60S ribosomal protein L4) RPL4 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GVPGKKPT;KEAVLLLKKLK;KLRMDKAAAALEAKSEEKG;PEIQRALRAPRKKIHRRVLKKNPL;VGKKGKKTVGVKKPKKPV;VGKKGKKTVGVKKPKKPVVGKK;VGKKGKKTVGVKKPKKPVVGKKAAA;VLKKNPLKNLRIMLKLNP 8 29.6 1.0024 -1.3591 0 0 0 0 0 11.8825 0 0 0 0 0 0 0 0 0 A0A8I3NNA3 A0A8I3NNA3_CANLF AIG1-type G domain-containing protein GIMAP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525] GRGRWRRVLLLL;RRVLLLLGGALLLGLLLCRL 2 8.5 0.93232 0.098646 0 4.81972 0 0 4.14274 0 0 0 0 0 0 9.31583 0 0 0 A0A8I3NNA5 A0A8I3NNA5_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] PIDKKGNFNYIEFTC 1 10.1 0.95308 0.053903 0 0 0 0 0 0 0 0 0 0 0 0 9.31969 0 0 A0A8I3NNA9 A0A8I3NNA9_CANLF Seizure related 6 homolog SEZ6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATVHFSCAPGYVLKG;GLGGPDPL;IEGLLSSGR;PLPPVPTLGPGERP;SLDSPVAPSSPT;SPTHQAALRFQSLPP;VLGYQQGFVIHFFEV 7 9.1 1.0015 -0.91689 0 0 0 8.71032 0 0 11.3066 0 6.40932 0 0 7.92926 0 0 10.1659 A0A8I3NNB0 A0A8I3NNB0_CANLF Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) NADSYN1 Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] cytoplasm [GO:0005737] ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952] LEIWPVLH;VDFALSCRE 2 2.5 0.98985 -0.52691 5.75157 9.11821 0 10.5818 0 0 0 0 0 0 5.43433 5.42958 0 0 5.9934 A0A8I3NNB4 A0A8I3NNB4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] KVLILIVLLK;KVLILIVLLKLSL;LILIVLLKL;SSETLSFDFFSLFIAL;VIRSRDPRSKVLILIVLLKL;VIRSRDPRSKVLILIVLLKLS;VLILIVLLK 7 15.6 1.0045 -2.0099 0 0 0 0 5.76354 0 0 5.34883 5.87843 0 6.90316 8.21553 8.4685 9.55136 4.1933 A0A8I3NNC1 A0A8I3NNC1_CANLF Tudor domain-containing protein 7 TDRD7 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] RNA binding [GO:0003723] EDEMKEYYSKNPK;PSVLVVEL;YKEELNQGILQQFEHWPHICTVE 3 4.3 0.98842 -0.47586 0 2.43173 0 0 0 8.95829 0 0 0 0 0 9.98342 13.6867 0 0 A0A8I3NNC4 A0A8I3NNC4_CANLF Neurogenic differentiation factor NEUROD2 Canis lupus familiaris (Dog) (Canis familiaris) associative learning [GO:0008306]; axon development [GO:0061564]; behavioral fear response [GO:0001662]; cellular response to calcium ion [GO:0071277]; cellular response to electrical stimulus [GO:0071257]; cerebellar cortex development [GO:0021695]; negative regulation of synapse maturation [GO:2000297]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein ubiquitination [GO:0016567]; sensory organ development [GO:0007423] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]" KRGPKKRKMTKARLERSKLRRQK;YAAAGGGGA;YAAAGGGGASPDYNSSE 3 10.5 0.9882 -0.22689 0 0 0 0 5.64062 0 0 0 0 0 0 0 0 0 0 A0A8I3NND7 A0A8I3NND7_CANLF Carbonic anhydrase-related protein 10 CA10 Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] EDSQGSEH;FGSEDSQGS;IHEGWWAYK 3 9.6 1.0015 -0.69753 11.5321 11.2482 11.3407 8.34678 0 8.29591 11.9579 12.0603 12.1373 11.8362 12.4023 11.918 11.118 11.1916 11.1775 A0A8I3NNF6 A0A8I3NNF6_CANLF Replication protein A subunit RPA1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] PML body [GO:0016605] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DKFFPLIDMNKVYYI;VPYNEGHGQQQAV 2 4.5 0.99135 -0.18583 0 0 0 0 6.8226 0 0 0 0 0 0 8.23692 0 0 10.794 A0A8I3NNF7 A0A8I3NNF7_CANLF N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) CMAS Canis lupus familiaris (Dog) (Canis familiaris) N-acetylneuraminate metabolic process [GO:0006054] N-acylneuraminate cytidylyltransferase activity [GO:0008781] ATSPCLHPTDLQKVAEM;HLAALVLARGGSKG;NIQATSPCLHPT 3 8.6 0.99883 -0.61006 0 0 0 0 0 9.39911 0 0 0 0 0 11.7214 0 0 0 A0A8I3NNF8 A0A8I3NNF8_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GINAEITYSFKTLRDIGNM 1 2.4 0.95286 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 5.17089 0 A0A8I3NNF9 A0A8I3NNF9_CANLF Potassium two pore domain channel subfamily K member 13 KCNK13 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] potassium channel activity [GO:0005267] AGRACGCSCGPGHLN;LYFCFVAFSTIG 2 6.6 0.9352 0.10433 0 0 0 0 0 0 0 0 7.94105 0 0 0 0 7.76792 0 A0A8I3NNG0 A0A8I3NNG0_CANLF Rhomboid-related protein 3 (EC 3.4.21.105) RHBDL3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] QRLQDQSLWWIF 1 3 0.94745 0.05044 0 0 0 0 0 0 0 0 7.58015 0 0 0 0 0 0 A0A8I3NNG1 A0A8I3NNG1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] LHISSQEGRSKAFST;VLKISMVWWRVTYK 2 13.1 0.91693 0.11466 0 0 9.04319 0 0 0 0 0 0 8.72079 0 0 0 0 0 A0A8I3NNG7 A0A8I3NNG7_CANLF NIPA like domain containing 3 NIPAL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] PDLLLLDF 1 2.2 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 3.46388 9.02774 0 0 8.85125 A0A8I3NNH2 A0A8I3NNH2_CANLF RNA binding motif protein 14 RBM14 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] nucleolus [GO:0005730] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] TAPVPTVG;TTPEELAA;VEAIRGLDNTE 3 5.6 1.0017 -1.2735 10.9526 0 10.4992 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NNH8 A0A8I3NNH8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MIB1 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; neuron differentiation [GO:0030182]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; cytoplasmic vesicle [GO:0031410] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] AGHTAMQAASQNGHV;CGHMCACE;DGTMCDTC;DLEIVQSLQHGH;EIQDWSASSPHS;EVCGTSWTYNPAAV;GAVIEVLHRGS;LQDIKEQTMCPVCLDRLKNMIFLC;LSQLRQLQDMQ;PCGHMCACENCASLMKKCVQC;PICRKAIERRILL 11 14 0.9975 -3.4157 5.05602 0 0 0 8.56079 4.64927 0 10.8156 6.87234 0 0 11.2686 9.37897 0 11.6132 A0A8I3NNI1 A0A8I3NNI1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] actin binding [GO:0003779] LLIAEGDLDAQRSE 1 5.3 0.99063 -0.21351 0 0 0 0 0 0 0 0 10.7248 0 0 0 0 0 0 A0A8I3NNI4 A0A8I3NNI4_CANLF proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) PARS2 Canis lupus familiaris (Dog) (Canis familiaris) prolyl-tRNA aminoacylation [GO:0006433] cytoplasm [GO:0005737] ATP binding [GO:0005524]; proline-tRNA ligase activity [GO:0004827] TDAQGRPCPAEMGCYG;VGSIGGTASHEFQLP 2 6.5 0.99016 -0.2113 0 0 0 0 0 0 8.16586 0 0 0 0 0 0 0 0 A0A8I3NNI7 A0A8I3NNI7_CANLF Ciliary microtubule inner protein 1 CIMIP1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] AAQRMNLVAQD 1 8 0.98322 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.56447 A0A8I3NNJ0 A0A8I3NNJ0_CANLF Vacuolar protein sorting-associated protein 16 homolog VPS16 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; vacuole organization [GO:0007033] CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; recycling endosome [GO:0055037] AWERRLMVVGDAP;EKESQKADEYLREIQELGQLTQ;FFMTLRNQPMALSLYRQFCKH;FLHEVPVASE;LDHAACSAVTLPGLAP;LVPELDGVRIFSRSTH;LVYGLHGDFRRHFSMGNEVLQNR;PGVSSFLQMAVSFTY;VLLHLKNE 9 17.5 1.0029 -1.3322 9.45804 0 11.8912 6.21486 6.67765 4.48594 8.68159 0 0 0 0 0 0 0 7.7414 A0A8I3NNJ2 A0A8I3NNJ2_CANLF Interleukin 17B IL17B Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; positive regulation of cytokine production involved in inflammatory response [GO:1900017] extracellular space [GO:0005615] cytokine activity [GO:0005125] QLWLSNKRSLSPW 1 7.2 0.938 0.059566 9.71702 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NNK0 A0A8I3NNK0_CANLF Vacuolar protein sorting 45 homolog VPS45 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] CCQGRNWDP;IADMKAFVENY 2 3.9 1.0027 -0.76872 0 0 7.00506 0 0 0 0 0 0 0 0 0 7.49873 0 0 A0A8I3NNK1 A0A8I3NNK1_CANLF Solute carrier organic anion transporter family member SLCO1C1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] AGIVSLLAAVPFWCLPKSLPRLR;NLFGNPLY;VISVITSYTLSLGGIPGYM 3 7.5 1.0032 -1.1135 4.63836 0 10.7694 0 0 9.00977 0 0 6.94918 0 0 10.6246 0 11.2826 0 A0A8I3NNL6 A0A8I3NNL6_CANLF GON7 subunit of KEOPS complex GON7 Canis lupus familiaris (Dog) (Canis familiaris) tRNA threonylcarbamoyladenosine modification [GO:0002949] cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] EAAAAEEAMDGDDEDDAEDEN;EAMDGDDEDDAED;EAMDGDDEDDAEDEN;QDREAAAAEEAMDGDDEDDA;QMRELVAELF 5 34 1.0016 -0.7034 0 0 6.84649 0 6.54861 0 0 6.79299 0 0 8.83996 0 0 0 0 A0A8I3NNL7 A0A8I3NNL7_CANLF Chromosome 2 C1orf232 homolog C2H1orf232 Canis lupus familiaris (Dog) (Canis familiaris) DTVAGFKWGFLTHKLAEM;ESEEDLAEERGN 2 16 0.98808 -0.49164 0 0 12.1521 0 10.007 0 0 0 0 0 0 0 0 0 0 A0A8I3NNM1 A0A8I3NNM1_CANLF Uncharacterized protein TAB3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130] LHQRARMERLAKQL;LQSRDSSDPCTI;PWNCDSCT;QPRDEDYEGAPWNCDSC 4 6.4 0.99883 -0.61079 0 0 0 0 7.90256 0 8.16952 0 8.31615 0 0 0 10.4678 0 0 A0A8I3NNM9 A0A8I3NNM9_CANLF ATPase family AAA domain containing 2 ATAD2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DDDGEDEDDDDEEDGEEDNQ;DDDGEDEDDDDEEDGEEDNQKR;DEDDDDEEDGEEDNQ;DEEDGEEDNQ;EDDDGEDEDDDDEED;EDQEDDDGEDEDDDD;EEGEDQEDDDGEDEDDD;GSVESSEEGEDQEDDDGED;HTRDWNPKPLDI;IFLRNVTHRL;KQAAKPPVSKKKAVL;LDSRGEIVVIGATNRLDSIDPA;PHSALPEEVQELFIRDYGEIFNVQ;PVSKKKAVLQ;QEDDDGEDEDDDDE;QEDDDGEDEDDDDEE;QEDDDGEDEDDDDEEDGEED;QEDDDGEDEDDDDEEDGEEDNQ;SEEGEDQEDDDGE;SVESSEEGEDQEDDDGEDEDDDDE 20 8.7 1.0006 -0.92895 13.2107 6.05639 12.0778 8.66399 5.35868 8.18884 6.38376 10.1137 7.74133 0 0 0 0 6.20655 7.58586 A0A8I3NNN6 A0A8I3NNN6_CANLF T-cell surface glycoprotein CD8 alpha chain CD8A Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] plasma membrane [GO:0005886] LLFLFPLSGRFSGRQS;NSILYFSPFVPVFLPVKPP 2 11.7 0.98796 -0.50495 9.33199 0 0 0 0 10 0 0 0 0 0 0 0 0 0 A0A8I3NNN8 A0A8I3NNN8_CANLF Bardet-Biedl syndrome 1 BBS1 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515] BBSome [GO:0034464] AAILTMNLLEQR;PSVPVFLE;VGLVRVHKV;VGLVRVHKVLV 4 6.2 1.0034 -1.521 0 0 0 0 0 0 3.17828 0 0 0 0 0 0 0 7.71177 A0A8I3NNP1 A0A8I3NNP1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EIKRNDAQPAVY;FYPKDINV;LFQPSPDQLHTG 3 14.3 1.0027 -1.1414 0 0 11.3296 0 0 0 0 0 0 9.34452 0 10.5649 0 0 0 A0A8I3NNP3 A0A8I3NNP3_CANLF Cyclin D3 CCND3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell population proliferation [GO:0042127]; signal transduction [GO:0007165]; T cell proliferation [GO:0042098] cyclin D3-CDK4 complex [GO:0097130]; nucleoplasm [GO:0005654] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase binding [GO:0019901] ELLCCEGTRH;LAMNYLDRYLS;LCIYTDHSVSPRQLRDW;YFQCVQREI 4 16.1 1.0017 -0.7515 0 0 0 0 0 0 0 10.9218 10.3024 0 0 0 0 0 8.56727 A0A8I3NNP9 A0A8I3NNP9_CANLF Phosphotransferase (EC 2.7.1.-) GCK Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] TDATRSQAQTALS 1 2.8 0.93803 0.059743 0 0 0 4.82584 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NNQ3 A0A8I3NNQ3_CANLF Dynein light chain roadblock-type 1 MAP1LC3A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADRCKEVQQIRDQHPSKI;NPTTTQYANLMHNF;SELVKIIRRRLQLNP 3 24.7 0.95107 0.053874 0 0 0 0 3.92305 0 0 0 0 0 0 0 0 0 0 A0A8I3NNQ5 A0A8I3NNQ5_CANLF Small integral membrane protein 24 SMIM24 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TGFRMCSNPYQD;TGFRMCSNPYQDVG 2 10.8 0.98678 -0.39654 0 20.0755 0 0 0 0 0 0 0 9.34514 20.1983 0 0 0 0 A0A8I3NNQ7 A0A8I3NNQ7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DYTKRSCL 1 2.6 1.0042 -1.1044 0 0 0 8.27198 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NNQ9 A0A8I3NNQ9_CANLF Mitoferrin-1 (Mitochondrial iron transporter 1) (Solute carrier family 25 member 37) SLC25A37 Canis lupus familiaris (Dog) (Canis familiaris) iron import into the mitochondrion [GO:0048250] membrane [GO:0016020]; mitochondrion [GO:0005739] NAVLHHQGNSHLANGIAGS;STHVCTHH;THHVAGWVAL 3 10.1 1.0029 -0.7851 0 0 0 9.28413 0 0 0 10.4013 0 0 9.53601 0 0 0 0 A0A8I3NNR4 A0A8I3NNR4_CANLF CDK5 regulatory subunit-associated protein 2 CDK5RAP2 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; centriole replication [GO:0007099]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] cell junction [GO:0030054]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; Golgi apparatus [GO:0005794]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471] calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; transcription cis-regulatory region binding [GO:0000976] AAEGDTLRFTNQ;AIITVLCGTEGGQD;DVLSKPKGSA;EGFQEQLNQCAGL;GELGHLAHVD;PLAGAAGA;QMIRSLRGS;RFLGSFLLPDVSEETV;TAGPHSVG 9 5.3 1.0023 -1.1742 10.6116 0 5.83036 0 0 0 8.41164 10.2784 0 0 0 0 0 0 0 A0A8I3NNR5 A0A8I3NNR5_CANLF R3H domain containing 1 R3HDM1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] IDLHEFLVNTLKNNP;IMTAAPPPH;IQQPSPQMPACYCA;ISQENQEKIQ;PSVHYNSHLN;QEILDFIGNNESPR;VNKTSNTRIPDQKFNEH 7 8.1 0.99388 -0.17269 0 0 10.2253 0 6.92065 0 8.09656 0 10.7243 0 0 9.17265 0 7.01536 0 A0A8I3NNS0 A0A8I3NNS0_CANLF adenosylmethionine decarboxylase (EC 4.1.1.50) AMD1 Canis lupus familiaris (Dog) (Canis familiaris) spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597] cytosol [GO:0005829] adenosylmethionine decarboxylase activity [GO:0004014]; identical protein binding [GO:0042802]; putrescine binding [GO:0019810] LLLKALVPLLKLA;MGRMNSDCWYLYTLDFPETRVISQ;QSLIKMKKKRK;TTLLLKALVPLLKL 4 10.8 0.99093 -0.13528 4.80761 0 0 0 0 0 0 9.6392 0 0 6.67723 0 0 5.6102 0 A0A8I3NNS3 A0A8I3NNS3_CANLF F-box and leucine rich repeat protein 20 FBXL20 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] FAPVTPPP;NWQRIDLFDFQR 2 5 0.99296 -0.18781 0 0 0 0 0 0 14.8421 0 0 0 0 0 4.79893 0 0 A0A8I3NNS6 A0A8I3NNS6_CANLF FA complementation group L FANCL Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ubiquitin protein ligase activity [GO:0061630] LITLKLKTK;PTRSATTRRIALVVKPLGIKL 2 8.6 0.9747 0.047166 0 0 0 0 0 0 0 0 8.39373 0 0 0 0 0 0 A0A8I3NNS9 A0A8I3NNS9_CANLF Hexosyltransferase (EC 2.4.1.-) CSGALNACT1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] DELAPEQYKMCMQ;FDLDIRGWGGE;FLRSQVDKAEVHTGVK;PPLEQQLVIKKETGF 4 10.4 0.99147 -0.13864 0 0 0 7.87061 0 0 0 10.5653 0 0 0 0 10.955 0 0 A0A8I3NNT4 A0A8I3NNT4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] TCEPSCAVSSLSSCCQPVCCETPSC 1 12.8 0.97556 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 5.29514 0 A0A8I3NNU5 A0A8I3NNU5_CANLF CCR4-NOT transcription complex subunit 11 CNOT11 Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634] GGGGGGGG;MEVVNRLTTAVDLPP;PSILSDPD 3 6.2 1.0027 -1.1587 9.91302 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NNV4 A0A8I3NNV4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCPSCCLR;CCDSSSCGSSCCR;CCDSSSCGSSCCRPSCCCPSCC;CCHPSCCDSSSC;CCHPSCCDSSSCGSSCC;CCHPSCCDSSSCGSSCCR;CCISSCCHPSCCDSSSCGSSCCRP;CCRPSCCCPSCCLRPVFCG;CDSSSCGSSCCRPSCCCPSCCL;DSSSCGSSCCRPSCCCPSCCL;DSSSCGSSCCRPSCCCPSCCLRPVF;GSSCCRPSCCCPSCCLRPV;ICCISSCCHPSCCDSSSCGSSCCRP;ISSCCHPSCCDSSSCGSSC;PSCCDSSSCGS;PSCCDSSSCGSSCC;PSCCDSSSCGSSCCRP;PSCCDSSSCGSSCCRPSCCCPSCC;SCCDSSSC;SCCDSSSCGSSCC;SCCDSSSCGSSCCRPSCCCPSCC;SCCHPSCCDSSSCGSSCCRPSC;SSCCHPSCCDSSSCGSS;SSCCHPSCCDSSSCGSSC;TICCISSCCHPSCCDSSSCGSSC;TICCISSCCHPSCCDSSSCGSSCC 26 21 1.0033 -1.6899 0 9.36225 8.21602 5.58502 0 6.66519 7.26576 0 5.44854 8.76746 6.50231 0 7.11936 4.41556 8.48257 A0A8I3NNV6 A0A8I3NNV6_CANLF Programmed cell death 1 ligand 2 PDCD1LG2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILSIIIVLIFITTMIALRK;MTCFLPLLQERCQVLMCQ;TKTSQGLYQVTSV;VVILSIIIVLIFITTM 4 15.9 0.80928 0.21814 0 10.3912 0 4.45022 0 0 0 0 6.5658 0 0 0 0 0 0 A0A8I3NNW1 A0A8I3NNW1_CANLF Intraflagellar transport 43 IFT43 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721] centriolar satellite [GO:0034451]; centriole [GO:0005814]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991] EDVQEEDFALQVAAPP;LGLSVGHLKLH 2 12.8 0.9904 -0.21056 12.2351 0 6.44994 3.33657 0 0 0 0 12.901 0 0 0 0 0 0 A0A8I3NNW2 A0A8I3NNW2_CANLF Vascular cell adhesion molecule 1 VCAM1 Canis lupus familiaris (Dog) (Canis familiaris) amine metabolic process [GO:0009308]; cell-cell adhesion in response to extracellular stimulus [GO:0140039]; cell-matrix adhesion [GO:0007160]; cellular response to amyloid-beta [GO:1904646]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; inflammatory response [GO:0006954]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102] alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; podosome [GO:0002102] cell adhesion mediator activity [GO:0098631]; integrin binding [GO:0005178]; primary amine oxidase activity [GO:0008131] EDPILTLTSAKMEDSGI;EIELFKGETIIES;SDRLEIELFKGETIIES;SKNEAGLQLRSLT;YKEQTFHFTP 5 6.9 1.002 -0.68485 0 0 0 11.5405 9.41528 0 0 0 8.69491 0 10.3993 10.0825 0 0 10.7192 A0A8I3NNX3 A0A8I3NNX3_CANLF Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) LOC102152698 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] centrosome [GO:0005813]; spindle pole [GO:0000922] microtubule binding [GO:0008017] DMLAWINESL;QQVNVLKLTVEDLDKERDFYF;VEDLDKERDFYFGKL;VQWFKKFF 4 15.7 1.0034 -1.6143 0 0 6.76275 0 0 0 10.3656 0 9.68099 0 8.80986 0 0 0 0 A0A8I3NNX4 A0A8I3NNX4_CANLF Zinc finger protein 646 ZNF646 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVEALDGAGYG;GYGHICGCCGQTYDD;KVELPPDQVE;LQPESHPFSCSCCGKTYCQSEGPL;NLMALKNHSRLHAQYQPYQCPHCPR;PGSLVNHRRTHE;QLSEAELLNQLQR;VVNFTGGQELAQ;YSCPTCPKTYSNGV 9 7.5 0.99371 -0.057675 13.0079 10.9432 11.0672 11.3689 12.0561 11.6925 0 0 10.6651 10.992 11.211 0 13.0022 9.93832 0 A0A8I3NNY6 A0A8I3NNY6_CANLF Nuclear cap binding protein subunit 1 NCBP1 Canis lupus familiaris (Dog) (Canis familiaris) "7-methylguanosine mRNA capping [GO:0006370]; defense response to virus [GO:0051607]; histone mRNA metabolic process [GO:0008334]; mRNA export from nucleus [GO:0006406]; mRNA transcription by RNA polymerase II [GO:0042789]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell growth [GO:0030307]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of translational initiation [GO:0006446]; snRNA export from nucleus [GO:0006408]; spliceosomal complex assembly [GO:0000245]" cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340] FRWSWEDWSDCLTQDPESPKP;GEFVEAMIRQL;HCIIKSHWKERKTCA;HVLKIQKELEEA;LPEKLTIYTTLV;NCHVIAAPSMVAMFEN;SLKANNYNEA 7 12.3 1.0026 -0.84173 0 0 10.7673 0 0 8.90162 0 0 0 10.8737 0 5.35878 8.28388 0 9.55009 A0A8I3NNZ2 A0A8I3NNZ2_CANLF Fibroblast growth factor receptor (EC 2.7.10.1) FGFR1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; auditory receptor cell development [GO:0060117]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium ion homeostasis [GO:0055074]; cardiac muscle cell proliferation [GO:0060038]; cell maturation [GO:0048469]; cell projection assembly [GO:0030031]; cementum mineralization [GO:0071529]; chondrocyte differentiation [GO:0002062]; diphosphate metabolic process [GO:0071344]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic cell cycle DNA replication [GO:1903465]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; regulation of lateral mesodermal cell fate specification [GO:0048378]; regulation of phosphate transport [GO:0010966]; regulation of phosphorus metabolic process [GO:0051174]; response to sodium phosphate [GO:1904383]; sensory perception of sound [GO:0007605]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; ureteric bud development [GO:0001657]; ventricular zone neuroblast division [GO:0021847]; vitamin D3 metabolic process [GO:0070640] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; receptor-receptor interaction [GO:0090722]; SH2 domain binding [GO:0042169] ALEERPAAMTSPLYLE;DDDDDDDSSSEEKET;EDDDDDDD;GVSLKRKIKLRT;LPEQAQSWGAP;SEDDDDDDDS;TVSADSSASM 7 7.7 1.0034 -1.5427 0 5.60626 8.19007 0 4.33034 12.9367 0 0 0 0 0 0 0 4.05546 0 A0A8I3NNZ5 A0A8I3NNZ5_CANLF Musashi RNA binding protein 2 MSI2 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; regulation of translation [GO:0006417] cytoplasm [GO:0005737] mRNA binding [GO:0003729] CLVNPRTA;EIRECMVMRDPTTKRSRGFGFVTF 2 10.4 1.0046 -1.1044 0 0 0 0 0 0 0 0 0 9.88657 0 0 0 0 0 A0A8I3NNZ9 A0A8I3NNZ9_CANLF Sulfotransferase (EC 2.8.2.-) SULT4A1 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] cytosol [GO:0005829]; mitochondrion [GO:0005739] identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146] LPLPCARTVGPA;SLPWAQFP 2 5.1 1.0026 -1.3493 0 0 10.7311 0 0 0 8.97034 0 0 10.4805 0 0 0 0 0 A0A8I3NP09 A0A8I3NP09_CANLF Family with sequence similarity 174 member C FAM174C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] LAALYFLIRAFRLKKPQ;LPLLPLLLLLSALL;PPPPLLPLLPLLLLLSALL 3 26.5 0.917 0.11018 4.98057 0 0 0 0 0 0 0 0 0 0 0 0 0 4.20821 A0A8I3NP13 A0A8I3NP13_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAP4K4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLVKNTKGNTLKEDWIAYIS;EARRQQEREQRRRE;FFASVRSGG;FIGTPYWMAPE;GSCAGFHAVDVDSGSVYDIY;IDRTRKKRGEKDE;KKFFSFIE;PQSDTPEIRKY;SESVHPALQRPAEPQVPV;SSSEESGTTDEEDDDVEQEG 10 11.3 0.9744 0.048313 0 0 0 0 0 0 0 0 0 0 0 9.61209 0 0 7.91223 A0A8I3NP19 A0A8I3NP19_CANLF "Lipase G, endothelial type" LIPG Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular region [GO:0005576] heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; metal ion binding [GO:0046872] LTWEGAIQSWYNLWK;NVGEIEPNFYVT 2 5.7 0.99403 -0.17242 0 0 0 0 0 4.41 0 0 0 0 10.2957 0 0 0 0 A0A8I3NP24 A0A8I3NP24_CANLF Uncharacterized protein GCNT4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] RFTYHHELRQ 1 2.2 0.99204 -0.27086 9.09827 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NP28 A0A8I3NP28_CANLF thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; hydrogen peroxide catabolic process [GO:0042744]; leukocyte activation [GO:0045321]; removal of superoxide radicals [GO:0019430] cytosol [GO:0005829] thioredoxin peroxidase activity [GO:0008379] PAPNFKADEGIL 1 12.8 0.9538 0.05044 0 0 8.75084 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NP31 A0A8I3NP31_CANLF Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) MED20 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle cell differentiation [GO:0035914] core mediator complex [GO:0070847]; mediator complex [GO:0016592] transcription coactivator activity [GO:0003713] GVTCVSQMPVAEGKSVQQTVE 1 9.9 0.95384 0.04929 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.51306 A0A8I3NP43 A0A8I3NP43_CANLF 60S ribosomal protein L36 RPL36 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] ALKFIKKR;KVSKDKRALKFIKKR;VSKDKRALKFIKKRV 3 15.2 1.0014 -0.99663 3.60098 3.0312 0 0 0 0 0 0 0 0 0 0 7.45088 0 0 A0A8I3NP47 A0A8I3NP47_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HTGEKPYGCGECGKAFFQKSH;SLPCNVAVSPNAY 2 10.1 0.9919 -0.27782 0 0 0 0 0 0 0 0 0 0 0 0 5.97232 0 0 A0A8I3NP67 A0A8I3NP67_CANLF Pre-mRNA-splicing factor SYF2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" membrane [GO:0016020]; spliceosomal complex [GO:0005681] IVFHSLDFNEARK;NEARKLNHQEVVE 2 7.7 0.98662 -0.38504 0 0 0 0 0 0 0 0 0 10.1403 0 0 0 0 0 A0A8I3NP84 A0A8I3NP84_CANLF Solute carrier family 25 member 27 SLC25A27 Canis lupus familiaris (Dog) (Canis familiaris) response to cold [GO:0009409] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FGKSEDKHYPLWKSVIGGMMA 1 8.6 0.97786 0.047802 8.55551 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NP86 A0A8I3NP86_CANLF Solute carrier family 25 member 51 SLC25A51 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] DKFTNTYQAFK 1 3.7 0.98451 -0.24352 0 0 0 0 9.72656 0 0 0 0 0 0 0 0 0 0 A0A8I3NP93 A0A8I3NP93_CANLF Thioredoxin domain containing 11 TXNDC11 Canis lupus familiaris (Dog) (Canis familiaris) GSVPHIEENRY;SSSSSSSDDAEDEGGG 2 3 0.95789 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.29948 A0A8I3NPA6 A0A8I3NPA6_CANLF Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) MED1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to thyroid hormone stimulus [GO:0097067]; positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] nuclear retinoic acid receptor binding [GO:0042974]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coregulator activity [GO:0003712] SEKLSKMS;TIEGTSAMYKLPIAPLIMGSHP;VKKNLPPASSPGE;VTSLPAMTD;VVQRCMSIPVT 5 10.3 0.9909 -0.27317 0 0 0 0 0 0 0 10.0232 0 0 0 0 0 0 0 A0A8I3NPA9 A0A8I3NPA9_CANLF N-acetylglutamate synthase NAGS Canis lupus familiaris (Dog) (Canis familiaris) arginine biosynthetic process [GO:0006526]; glutamate metabolic process [GO:0006536] mitochondrion [GO:0005739] acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042] RRSVLLDSLEVT 1 2.2 0.95203 0.05044 0 0 0 0 0 0 0 0 0 0 6.23601 0 0 0 0 A0A8I3NPD1 A0A8I3NPD1_CANLF Homeobox B5 HOXB5 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell differentiation [GO:0045446] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AMHTGSYGYNYNGMDLSVNRSSA;PASSSANFTEID;RSSASSSHFGAVGES 3 17.1 0.99106 -0.13415 0 0 8.79721 0 0 0 0 0 8.05012 0 5.97673 5.64374 0 0 0 A0A8I3NPD8 A0A8I3NPD8_CANLF Hyaluronan and proteoglycan link protein 4 HAPLN4 Canis lupus familiaris (Dog) (Canis familiaris) "cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; inhibitory synapse assembly [GO:1904862]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501]; synaptic transmission, GABAergic [GO:0051932]" extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] hyaluronic acid binding [GO:0005540]; structural constituent of synapse-associated extracellular matrix [GO:0150043] ERYDAFCFTSNLPG;HDGVRLKWTKVVDPLA;IVNPRARCGGRR;RYKLTFTEAQRACAEQDGILAS;YRHNAEERYDAFCF 5 17.3 1.0025 -0.71425 8.14782 0 0 0 0 0 7.163 10.2494 0 0 0 0 0 0 10.1657 A0A8I3NPE3 A0A8I3NPE3_CANLF F-box and leucine rich repeat protein 19 FBXL19 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270] GVKGGRERHLKKKPKPPLAS;RCRACVRTECGDCHFCRDMK;RVCRTWSRWCYDKRLWPRMDLSR;SSSDSDSDSDSSGTS;VLPHTAVC;WCYDKRLWP 6 15.4 1.001 -0.92346 0 0 7.97114 8.62826 0 0 9.41198 0 0 8.30012 0 0 9.53473 0 6.68103 A0A8I3NPF0 A0A8I3NPF0_CANLF Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (Leucine zipper-EF-hand-containing transmembrane protein 1) LETM1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816]; potassium ion transport [GO:0006813] mitochondrial inner membrane [GO:0005743] antiporter activity [GO:0015297]; calcium ion binding [GO:0005509]; ribosome binding [GO:0043022] GVDSLNVKELQSACRARGMRA;LAFRANPRGCWT;LFEDELTLDNLTRPQ;QEIKKELSKTGEEIYVE 4 9.3 0.98676 -0.3319 0 0 0 0 0 0 11.3215 0 0 0 0 0 0 0 4.14853 A0A8I3NPF5 A0A8I3NPF5_CANLF Serine and arginine rich splicing factor 10 SRSF10 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607] RNA binding [GO:0003723] ERRRSRSRSFDYN 1 7.9 0.93919 0.059848 0 0 0 5.72156 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NPF7 A0A8I3NPF7_CANLF "Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1)" ALDH1B1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" QIIPWNFPLVM 1 2.1 0.98303 0.035491 0 0 0 0 0 7.07575 0 0 0 0 0 0 0 0 0 A0A8I3NPF8 A0A8I3NPF8_CANLF TNFR-Cys domain-containing protein LOC100688321 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EVFPSLKSLEQP;VVITITIIIVIVVVALI 2 8.7 0.97694 0.046227 0 0 0 3.00908 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NPG9 A0A8I3NPG9_CANLF Dynein axonemal intermediate chain 7 DNAI7 Canis lupus familiaris (Dog) (Canis familiaris) DTRLLSQWKHYIQCDG;EKWNQLESKDLERRNEELEELSLL;QLESKDLERRNEEL;TSKKVIVKL;VIFFEDPMVAR;WNAVCTSKKVIVKLS 6 12.5 1.0035 -1.1196 0 0 0 0 0 0 0 0 7.76494 0 0 0 13.6004 0 9.52845 A0A8I3NPH4 A0A8I3NPH4_CANLF Calcium dependent secretion activator CADPS Canis lupus familiaris (Dog) (Canis familiaris) dense core granule exocytosis [GO:1990504]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytoplasmic vesicle [GO:0031410]; presynapse [GO:0098793] DLQLHIYQLKTLIRMVKKTYRDFR;LCSMEMGQEHQYH;MTASAASELILSKEQL;NAKQPTDMAR;PTFSAPSWMAAIYDADNGS;TVKDRFQAFL;VLRDKVNEEMYIERLFDQWYNS;VNEEMYIERLFDQWY;YEHPVFCLASQVMDLTIQNVG 9 9.5 0.94771 0.054997 0 0 0 4.37044 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NPH7 A0A8I3NPH7_CANLF Uncharacterized protein SLC30A2 Canis lupus familiaris (Dog) (Canis familiaris) response to zinc ion [GO:0010043] plasma membrane [GO:0005886] antiporter activity [GO:0015297]; zinc ion transmembrane transporter activity [GO:0005385] AIELVAESN;EDMKDCQECQ 2 5.9 1.003 -0.85145 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.33491 A0A8I3NPI3 A0A8I3NPI3_CANLF Cadherin 17 CDH17 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; germinal center B cell differentiation [GO:0002314]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; integrin-mediated signaling pathway [GO:0007229]; marginal zone B cell differentiation [GO:0002315]; oligopeptide transport [GO:0006857]; positive regulation of integrin activation by cell surface receptor linked signal transduction [GO:0033626]; spleen development [GO:0048536] basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; proton-dependent oligopeptide secondary active transmembrane transporter activity [GO:0005427] DLCQLWRHFLFSFL;ILLTTFLVIGIILAVVFIRIKKN;PAMTFKLTGETDG;YFQINNKTGGISLT 4 7.3 1.0025 -0.71387 0 0 9.13743 0 0 7.60363 0 0 0 0 11.1932 9.6844 0 0 0 A0A8I3NPJ4 A0A8I3NPJ4_CANLF Thiamin pyrophosphokinase 1 TPK1 Canis lupus familiaris (Dog) (Canis familiaris) thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] ATP binding [GO:0005524]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788] CNSSYSGP;QPLDKCVRHLWSKALLR 2 10.1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 6.38774 0 0 0 0 0 A0A8I3NPK3 A0A8I3NPK3_CANLF Testis development related protein TDRP Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] PAAAAAAAAQVQGASF 1 8.6 0.99437 -0.078565 0 0 0 0 0 8.94275 0 11.3776 0 0 0 0 0 0 0 A0A8I3NPL3 A0A8I3NPL3_CANLF "Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Thioredoxin-dependent peroxiredoxin 3)" PRDX3 Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; mitochondrion [GO:0005739] thioredoxin peroxidase activity [GO:0008379] GTAVVNGE 1 3.1 0.98856 -0.26248 0 0 0 0 0 0 10.3589 0 0 0 0 0 0 0 0 A0A8I3NPM2 A0A8I3NPM2_CANLF RAS protein activator like 3 RASAL3 Canis lupus familiaris (Dog) (Canis familiaris) DLGAERDVRIWPL;PETPAPQIPEA;SQPASRSLFRRVLSSPPKESRTS;THRPVGKL 4 5.3 1.0033 -1.5206 10.4533 0 0 0 0 0 0 7.14883 0 0 0 8.71534 0 0 9.05677 A0A8I3NPM7 A0A8I3NPM7_CANLF Xanthine dehydrogenase XDH Canis lupus familiaris (Dog) (Canis familiaris) "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; xanthine dehydrogenase activity [GO:0004854]" GEAVYCDDIPRYEN;HGLEGISFGAACPL;IAEYWMSEVAMTCGLPAE;IPRYENELSL;ISETSTNTVPNTSP;IVHFSANACLAPICSLHHVA;LGCGEGGCGACTVMLS;NPAIDIGQVEGAFVQ;RALFHMDNCYKIPN;TGIFNDETIFAEDE 10 10.7 0.98221 -0.2507 0 0 0 0 0 9.13209 0 0 0 0 0 0 0 0 0 A0A8I3NPN6 A0A8I3NPN6_CANLF Luc7-like protein LUC7L3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA splice site recognition [GO:0006376] nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729] DRDERLKKEKQERE 1 3.4 0.94262 0.061085 0 0 0 0 0 6.32025 0 0 0 0 0 0 0 0 0 A0A8I3NPN7 A0A8I3NPN7_CANLF Claudin CLDN19 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] SYAGDAIITAVGLYEG;VGDSNPTAKG;VLLGFVAMVL;VLSVVGMKCTRVGDSNPTAK 4 22.1 1.0024 -1.0129 0 10.1478 0 0 0 10.9135 0 0 0 0 0 0 0 0 0 A0A8I3NPP7 A0A8I3NPP7_CANLF Meiosis/spermiogenesis associated 1 MEIG1 Canis lupus familiaris (Dog) (Canis familiaris) manchette assembly [GO:1905198]; protein localization [GO:0008104]; sperm axoneme assembly [GO:0007288] cytosol [GO:0005829]; manchette [GO:0002177]; nucleus [GO:0005634] YVKKLQRRDN 1 11.4 0.99892 -0.61146 0 0 0 0 0 0 0 0 0 0 10.3087 0 0 0 0 A0A8I3NPR6 A0A8I3NPR6_CANLF Zinc finger protein 831 ZNF831 Canis lupus familiaris (Dog) (Canis familiaris) ELSEHSDSCVAVAND;LALHFLGGSPQ;LEEGEKAGESSRADGMGDSCSQRVG;PEDPPSGP;SRTELDFP;TFFPPGGRYGYGEM;VGAKPGPC 7 5.4 1.0025 -1.1475 15.7992 7.68433 0 0 0 0 10.1659 0 0 0 5.98696 0 12.2524 0 0 A0A8I3NPR8 A0A8I3NPR8_CANLF LysM and putative peptidoglycan-binding domain-containing protein 3 LYSMD3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030] Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] peptidoglycan binding [GO:0042834] DIKRVNNLISDQD;TKGIPFGQHDHKLYSQ 2 9.5 0.99275 -0.19138 0 9.7061 0 0 0 0 0 7.13 0 0 0 0 0 0 0 A0A8I3NPS1 A0A8I3NPS1_CANLF Zinc finger protein 133 ZNF133 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GSSPVPTGNPEEADR;NHPPWVFA;QRSLYREVML;TNLLSHQRIHSGE;YMCRQCGL 5 8.1 1.0023 -1.757 0 0 0 0 8.12102 0 15.6502 9.56178 0 0 0 0 9.53945 0 0 A0A8I3NPS4 A0A8I3NPS4_CANLF Glucosylceramidase (EC 3.2.1.45) GBA1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; sphingolipid metabolic process [GO:0006665] lysosomal membrane [GO:0005765] glucosylceramidase activity [GO:0004348]; glycosyltransferase activity [GO:0016757] LDAYAEHKLQFWAV;VGSKFWEQSVRLGS;YVHGIAVHWYLDFLAP 3 9 0.9878 -0.47735 0 0 0 0 0 0 0 0 10.4996 9.97241 0 0 0 0 0 A0A8I3NPS6 A0A8I3NPS6_CANLF Olfactory receptor family 10 subfamily K member 1 OR10K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FVGCAIQMFT;LSSNQLHHYFCDI;LVVPLLLILVSYIRIISAILKIPS;VLVVPLLLILVSY 4 15.3 0.98689 -0.49996 0 0 0 0 9.69214 0 0 0 0 0 7.36606 0 0 0 0 A0A8I3NPU3 A0A8I3NPU3_CANLF Splicing factor 3B subunit 5 (SF3b5) SF3B5 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723]; splicing factor binding [GO:1990935] RYTIHSQLE 1 10.5 0.98841 0.018892 0 0 0 0 0 0 0 0 0 0 0 0 9.02323 0 0 A0A8I3NPU6 A0A8I3NPU6_CANLF Chromobox 1 CBX1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122] "chromocenter [GO:0010369]; chromosome, telomeric region [GO:0000781]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; spindle [GO:0005819]" chromatin binding [GO:0003682]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064] VISFYEERLTWH 1 6.5 0.94829 0.05044 0 0 0 0 0 0 0 12.4677 0 0 0 0 0 0 0 A0A8I3NPV1 A0A8I3NPV1_CANLF Chromosome 17 open reading frame 75 C17orf75 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle tethering to Golgi [GO:0099041] cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; trans-Golgi network [GO:0005802] LDVLDNSQKS 1 1.7 0.98798 -0.22473 0 10.1387 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NPV6 A0A8I3NPV6_CANLF Nuclear factor 1 NFIC Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TAIRYPPHLNPQDPLKDL;YLAYFVRERDTTDFQ 2 8.1 0.99345 -0.14287 0 0 0 9.33929 0 0 0 0 0 0 0 0 9.44303 0 0 A0A8I3NPW1 A0A8I3NPW1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FFSTSVGRFRER;VGRFRERPRLPAPSS 2 11.8 0.93602 0.10433 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.499 A0A8I3NPX0 A0A8I3NPX0_CANLF Intraflagellar transport 52 IFT52 Canis lupus familiaris (Dog) (Canis familiaris) dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; keratinocyte proliferation [GO:0043616]; negative regulation of keratinocyte proliferation [GO:0010839]; neural tube formation [GO:0001841]; non-motile cilium assembly [GO:1905515]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; dendrite terminus [GO:0044292]; intraciliary transport particle B [GO:0030992]; photoreceptor connecting cilium [GO:0032391] EDPEISDYMMLP;EVFTTNNG;LAFYHSKNQGG;SSRCSGGG 4 7.6 1.0039 -1.0548 0 0 0 0 0 0 0 0 0 8.42715 0 0 0 9.43085 0 A0A8I3NPX5 A0A8I3NPX5_CANLF Lecithin retinol acyltransferase LRAT Canis lupus familiaris (Dog) (Canis familiaris) retinol metabolic process [GO:0042572] phosphatidylcholine-retinol O-acyltransferase activity [GO:0047173] DQSLKKKALL;LEALSLLL;TVEDFAYGAD 3 12.2 1.0033 -1.6412 0 0 0 0 0 6.86307 0 0 7.89815 0 0 0 0 0 0 A0A8I3NPX6 A0A8I3NPX6_CANLF T-box transcription factor 18 TBX18 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AELWKRFHE;CCPGGCED;DCGDDLSPIKPVPSGEGVKAFS;QESPPPRIFSWS;STSVNMSMGGTDGDTFSCPQTS 5 11.3 1.0026 -1.7645 7.49697 0 0 0 5.69139 0 0 6.27601 0 0 0 0 9.67841 0 0 A0A8I3NPY4 A0A8I3NPY4_CANLF Sestrin 1 SESN1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of macroautophagy [GO:0016239]; regulation of response to reactive oxygen species [GO:1901031] cytoplasm [GO:0005737]; nucleus [GO:0005634] "L-leucine binding [GO:0070728]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]" DDYDYGEINQ;DDYDYGEINQL;GREAPLRPPDGLSPPAA;VGSEDAQMHSLF 4 7.3 1.0016 -0.70311 0 12.538 0 0 8.68064 0 0 0 0 0 0 0 0 9.13183 0 A0A8I3NPZ6 A0A8I3NPZ6_CANLF DNA helicase (EC 3.6.4.12) HFM1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] DLVTMISSCKEFV;EIAPEKNVSGN;EISHSKHSNRS;FAEDKGESTSAFRKRLFKISDNIHE;FDDLLYTDRNFVICAPTGS;IPAKFRSIFKEFPYFNYIQS;IVHSQERKQ;LNLTEAGN;NIALEWIRSTLLYIRALK;SRYHPDDEADEMKSFLGIFDDI;TLNYKIAG;VESSLHRHLIEHLNAEIVLHTITDV;YTDRNFVICAP 13 13.2 1.0019 -1.8028 0 11.6524 9.69549 6.59048 8.02652 0 9.09977 6.90436 11.4498 10.3475 9.20711 9.25441 8.10297 8.57387 8.36768 A0A8I3NQ15 A0A8I3NQ15_CANLF "Transcription elongation factor, mitochondrial" TEFM Canis lupus familiaris (Dog) (Canis familiaris) oxidative phosphorylation [GO:0006119]; transcription elongation by mitochondrial RNA polymerase [GO:0006392] mitochondrial nucleoid [GO:0042645]; ribonucleoprotein complex [GO:1990904] DNA polymerase processivity factor activity [GO:0030337]; nucleic acid binding [GO:0003676] EQQASILHVL 1 2.8 0.99935 -0.61146 0 0 0 0 0 0 0 0 5.68852 0 0 0 6.65306 9.79503 5.63854 A0A8I3NQ18 A0A8I3NQ18_CANLF Acidic leucine-rich nuclear phosphoprotein 32 family member ANP32E Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleus [GO:0005634] histone binding [GO:0042393]; phosphatase inhibitor activity [GO:0019212] APDSEEEDDEDGDEDDEEEEDE;APEEVTELVL;DDEDGDEDDEEEEDEA;DEDGDEDDEEEED;EAPDSEEEDDEDGDEDDEEE;EDEDEAGS;EDEDEDEAGSELGEGEEEVGL;EEDDDDYV;EEEEEEEEEDEDEDEDEAGS;GDEDDEEEEDEAGPPEEYEEEEEEE;IQDEEDDDDYVEEGEEEEEEEEE;PDSEEEDDEDGDEDDE;PDSEEEDDEDGDEDDEEEEDEA;QDEEDDDDYVEEGEEE;SEEEDDEDGDEDDEEEEDEAGPPEE 15 42.2 1.0023 -0.76408 13.3385 6.11314 6.97797 6.20746 8.67373 0 8.07457 0 12.6302 2.86993 0 7.46573 0 0 8.92238 A0A8I3NQ22 A0A8I3NQ22_CANLF Uncharacterized protein TMEM9B Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] CCCWCSCQTPPSDC;CCCWCSCQTPPSDCL 2 4.5 0.91702 0.11464 0 0 0 0 0 0 0 0 5.84356 0 0 0 0 0 5.67477 A0A8I3NQ24 A0A8I3NQ24_CANLF Ephrin A4 EFNA4 Canis lupus familiaris (Dog) (Canis familiaris) ephrin receptor signaling pathway [GO:0048013] plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875] LLLLLLLP;LLLLLLLPILRLLRVL;SPLCLLLLLLLPILRLLRV 3 9.8 0.9309 0.098643 0 0 0 0 3.54486 0 0 5.38132 0 0 0 0 0 0 0 A0A8I3NQ25 A0A8I3NQ25_CANLF Heat shock protein family A (Hsp70) member 12B HSPA12B Canis lupus familiaris (Dog) (Canis familiaris) AAEQSVALGEEVRRSYCP;AGALNISLPFSFI;DFITTFKRQ;FVAGRHPPE;LEPSEGAV;REQCPSLPEKDTVRWVL 6 10.9 1.0019 -1.8221 0 0 9.54822 0 0 0 8.22545 0 0 0 10.05 0 0 6.47233 0 A0A8I3NQ27 A0A8I3NQ27_CANLF PX domain-containing protein SNX12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] L-arginine transmembrane transporter activity [GO:0061459]; phosphatidylinositol binding [GO:0035091] FMAFLFELT;GAVRTPASGLCPPTPFPGP;GLFCPLSSIPTPLSGQVVYVCSSL;LVDLMSIGTLLAYS;VVYVCSSLVA 5 7.9 0.99156 -0.54671 0 0 0 0 10.5546 0 0 0 0 0 0 11.4734 0 0 8.21199 A0A8I3NQ33 A0A8I3NQ33_CANLF Olfactory receptor LOC119874718 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGLSSDWDT;LISLFYAILMPVLNPMIYSV 2 9.1 0.96357 0.048688 0 0 0 0 0 7.6565 0 0 0 0 0 0 0 0 0 A0A8I3NQ35 A0A8I3NQ35_CANLF Uncharacterized protein AFMID Canis lupus familiaris (Dog) (Canis familiaris) FFHGGYWQSGRHCAKEGGM 1 22.1 0.95276 0.049538 0 0 0 0 0 0 0 7.41143 0 0 0 0 0 0 0 A0A8I3NQ37 A0A8I3NQ37_CANLF TLC domain containing 5 TLCD5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMYAVSWCFMFSIWRFA;LSLYISFCRLNKHRSYEW 2 13.2 0.92886 0.09454 0 0 0 0 0 0 0 0 7.88069 0 0 0 0 0 0 A0A8I3NQ44 A0A8I3NQ44_CANLF Mex-3 RNA binding family member D MEX3D Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] CDFGFDFL;EHFSVIRATRS;GAGGGGGG;GGGGGGGA;GGGGGGGG;GGRKPPPA;GSGNGGFTFGGDGPGAPAG;KALRAKTNTYIK;PEDCDFGF;PVFAVTGM;PYGGGGSG;REESRRRRRRRRRRRRRRRRRR;RVQGHKREARDPEGGP;SRRRRRRRRRRRRRRRRRRPRPEQ;VGGGGGGG;VGGGGGGGG;VGRARVTGRGGARRR 17 15.9 0.99701 -5.9015 0 0 7.23276 6.84336 0 0 10.1997 0 6.21031 0 6.16104 10.169 0 8.37821 0 A0A8I3NQ62 A0A8I3NQ62_CANLF Argininosuccinate lyase ASL Canis lupus familiaris (Dog) (Canis familiaris) arginine biosynthetic process via ornithine [GO:0042450]; urea cycle [GO:0000050] cytosol [GO:0005829] argininosuccinate lyase activity [GO:0004056] VMEKFNSSIAYDRALWEVDVQ 1 4.8 0.97741 0.047759 0 0 10.1071 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQ69 A0A8I3NQ69_CANLF G protein-coupled receptor 20 GPR20 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] AAGAVTLSVLG;FVWMAAGAVTLSVLGVAAGSGP 2 6.2 0.94387 0.083585 0 0 0 0 0 10.3446 0 0 0 0 0 0 0 9.24022 0 A0A8I3NQ95 A0A8I3NQ95_CANLF calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) CAMK2B Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] LVFDLHCIQQILE 1 2.5 0.93481 0.065888 0 0 0 0 0 0 0 8.72052 0 0 0 0 0 0 0 A0A8I3NQ99 A0A8I3NQ99_CANLF Calpain catalytic domain-containing protein CAPN8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] LDAGVLFKDPEFPAC;LLGLMQKNCRRQK 2 4 0.98667 -0.33195 0 7.62534 10.808 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQA4 A0A8I3NQA4_CANLF Nucleoporin NUP35 (35 kDa nucleoporin) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) NUP35 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999] nuclear membrane [GO:0031965]; nuclear pore central transport channel [GO:0044613]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; phospholipid binding [GO:0005543]; structural constituent of nuclear pore [GO:0017056] PGLGSTPLT 1 2.4 1.0035 -0.80421 0 0 8.90491 0 0 0 0 0 0 8.3853 8.32868 0 9.25153 9.05205 0 A0A8I3NQA5 A0A8I3NQA5_CANLF ETS domain-containing protein ELF1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" DLVFEFASNVM;IIDDDDDD;VAEEEIIDDDDD;VAEEEIIDDDDDDITL;VEGQRLVYQFK 5 7.2 0.99444 -0.020435 0 14.0381 0 0 0 7.73207 0 0 9.87203 0 0 0 0 0 0 A0A8I3NQB5 A0A8I3NQB5_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8A1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] ALWVVFFG;DFNTKVFWVHCLNGLFHS;EAAMLFSSGV;EDYGCSPDEWQSSQ;FERWCIGLYNVMFTAMPPLTL;FIALLQQI;FSQDENGIVSQSEVIR;GVAYGHVPEPEDYG;GVFWMGLLF;HTAVPEREGDKI;LFNNLIPI;LLENLQNNHPTAPI 12 12.5 0.99855 -3.0003 11.6591 8.36663 9.9419 0 0 0 0 9.15869 0 0 0 0 9.61268 8.35028 0 A0A8I3NQC5 A0A8I3NQC5_CANLF SUMO interacting motifs containing 1 SIMC1 Canis lupus familiaris (Dog) (Canis familiaris) IDLTRTEEENRPI;ISDDSGSESS;KNTNQLEMFFT;QTWDELVEHLQFLLSSYQHV;SLCPPQDSPLGLPQDVPGPPQNISY;VEWDWKLLTYVMEEEGQNLPG;VIDRKDLIIKRI;VIDRKDLIIKRIKPK 8 12.8 1.002 -1.215 0 0 3.37016 8.35949 0 0 0 8.03414 0 0 8.40369 0 9.01302 8.29815 8.57008 A0A8I3NQC6 A0A8I3NQC6_CANLF SS18 subunit of BAF chromatin remodeling complex SS18 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription coactivator activity [GO:0003713] MQNQMNGQMPGP;PQQYSGQEDYYGDQYSHG;PSQGGPGP;PYGYDQGQ;TPAAIQKMLD;TSECSQYQ;YPPQQQQYP;YSGQEDYYGDQYSHG 8 18.9 0.9986 -3.006 11.8243 10.4284 6.46814 8.69105 9.65295 0 0 4.73704 7.21616 2.93425 9.49141 7.30716 0 0 0 A0A8I3NQD6 A0A8I3NQD6_CANLF Potassium voltage-gated channel subfamily H member 4 KCNH4 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated potassium channel activity [GO:0005249] DLIAALPFDLL;GHGDSNHEN;HLLKTVRLLRLLRLL;HYYVCSGSLE;LVHLLKTVRLLRLLRLLQKL;RLLRLLRLLQK;SLVHLLKTVRLLRLLRL;TVRLLRLLRLLQ;TVTSLVHLLKTVRLLRLLRL 9 5.3 1.0023 -1.3675 0 4.5043 0 0 9.58209 5.27676 0 0 0 0 0 0 0 0 0 A0A8I3NQE3 A0A8I3NQE3_CANLF Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Urate exporter) ABCG2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane [GO:0031966] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] MSEQGRTI;QLKWISKRSF;RYGYAALQ;STEVAVLS 4 5.3 1.0022 -1.2356 8.16922 0 0 0 0 0 0 0 0 0 9.627 0 0 0 10.5438 A0A8I3NQF3 A0A8I3NQF3_CANLF Inhibitor of growth protein ING2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; flagellated sperm motility [GO:0030317]; male germ-line stem cell asymmetric division [GO:0048133]; male meiosis I [GO:0007141]; negative regulation of apoptotic signaling pathway [GO:2001234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286] CCAAT-binding factor complex [GO:0016602]; plasma membrane [GO:0005886]; Sin3-type complex [GO:0070822] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877] FSCVSLTYKPKGKWYC;MQRNVSVLRE;PKEKKSKSAKKKKRSK 3 15 0.99276 -0.16853 0 10.7682 0 0 0 0 0 0 0 0 5.09512 0 0 10.5204 0 A0A8I3NQF9 A0A8I3NQF9_CANLF GA binding protein transcription factor subunit alpha GABPA Canis lupus familiaris (Dog) (Canis familiaris) blastocyst formation [GO:0001825]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TLDGTKHITTI 1 2.4 0.97972 0.035491 0 0 0 0 0 0 6.22448 0 0 0 0 0 0 8.34101 0 A0A8I3NQG4 A0A8I3NQG4_CANLF Sodium channel protein SCN2A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] IRLARIGRILRLIKGA;LEDLDPYYI;LFVPHRHG;LRDPWNWLDFTVITFAYVTEFVNLG;PLSEDDFEMFYE;QLKKQQEEAQ;RVIRLARIGRILRLIKGAK;SELGAIKSLRTLRALRPLR;SKLSSKSEKELKNRRKKKKQKE;VEHNWFET;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGIRTL;VIRLARIGRILRLIKGAKGIRTLL;VLRSFRLLRVFKLAKSWPTLN 15 7.9 0.98545 -0.2456 12.5903 0 0 0 0 0 0 6.08108 13.8805 0 0 0 0 0 0 A0A8I3NQG9 A0A8I3NQG9_CANLF Hydroxysteroid 11-beta-dehydrogenase 1-like protein (11-beta-hydroxysteroid dehydrogenase type 3) HSD11B1L Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; nucleoplasm [GO:0005654] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" QAVRQAVPAI;SYVQLTSLALPSL 2 6 0.98697 -0.40855 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7732 8.84185 A0A8I3NQJ6 A0A8I3NQJ6_CANLF Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) SLC39A12 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion transmembrane transporter activity [GO:0046873] LHLLPQVLGLHKQE 1 2.2 0.93097 0.060769 0 0 0 5.50182 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQK0 A0A8I3NQK0_CANLF Cilia and flagella associated protein 119 CFAP119 Canis lupus familiaris (Dog) (Canis familiaris) DLHKACVATPLGNVEE;TEEMREVLAELLGLGYPEQSLRDA 2 12 0.91934 0.11219 0 0 0 8.29228 0 10.0716 9.5247 0 0 0 0 0 0 0 0 A0A8I3NQK9 A0A8I3NQK9_CANLF 3-hydroxyisobutyrate dehydrogenase (HIBADH) (EC 1.1.1.31) HIBADH Canis lupus familiaris (Dog) (Canis familiaris) valine catabolic process [GO:0006574] mitochondrion [GO:0005739] 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661] LKKVKKGS;TFMVGGVEDEFAAAQE;VGAARSGN 3 9.5 1.004 -1.1044 7.35288 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQL6 A0A8I3NQL6_CANLF Calcium-binding and coiled-coil domain-containing protein 2 (Nuclear domain 10 protein NDP52) CALCOCO2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of autophagosome maturation [GO:1901098]; xenophagy [GO:0098792] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605] metal ion binding [GO:0046872] DEYYQFCYVDQ;FRPENEEDILVVTTQ;VIFNSVEKFYVP 3 9.3 0.99355 -0.061162 0 0 4.04763 7.75889 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQM4 A0A8I3NQM4_CANLF DEP domain containing 1 DEPDC1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634]; transcription repressor complex [GO:0017053] EELCNGKCK;HFSQENIEKMNH;LANWPRSN 3 3.6 1.0025 -1.8582 0 8.37356 0 0 0 0 0 0 0 9.12665 0 0 0 0 0 A0A8I3NQN0 A0A8I3NQN0_CANLF Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (Ubiquitin carrier protein B) (Ubiquitin-protein ligase B) UBE2B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cAMP-mediated signaling [GO:0043951]; postreplication repair [GO:0006301]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein stabilization [GO:0050821]; response to UV [GO:0009411]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; HULC complex [GO:0033503]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; replication fork [GO:0005657] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625] SEEYPNKPP 1 5.9 0.97316 0.037868 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9451 A0A8I3NQN9 A0A8I3NQN9_CANLF T-complex protein 1 subunit delta CCT4 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] FADAMEVIPST;MDRVLREERAY;VIRCLVKKRALI;VLSQKVANSGITR 4 9.2 0.989 -0.51876 0 11.873 0 0 10.4112 5.42864 0 0 0 0 0 0 0 0 10.7957 A0A8I3NQP3 A0A8I3NQP3_CANLF Ectonucleoside triphosphate diphosphohydrolase 4 ENTPD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; hydrolase activity [GO:0016787] HRRTLRSASTA;KVSDYISPLLSFAAEHIPRAKH;LVVVLSILLYLLRLRRIHRRTLR;SASTATLWLEEGLPSQ 4 10.2 0.9912 -0.26962 0 0 9.69728 0 0 0 0 0 6.08181 0 0 0 0 0 0 A0A8I3NQP4 A0A8I3NQP4_CANLF "Large ribosomal subunit protein mL37 (39S ribosomal protein L37, mitochondrial)" MRPL37 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] RPTPVHEQPLYKD;VGPTGFQPE;YDIPGLEPITY 3 7.8 1.0021 -1.2676 0 0 9.75732 0 0 0 0 11.2381 0 8.92267 0 0 0 0 0 A0A8I3NQQ9 A0A8I3NQQ9_CANLF Ring finger protein 32 RNF32 Canis lupus familiaris (Dog) (Canis familiaris) CPICLTPLPGSG;EDPEKEYVLDPKPP 2 7.6 0.98799 -0.47153 9.98826 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQR0 A0A8I3NQR0_CANLF UDP-N-acetylglucosamine transferase subunit ALG14 ALG14 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] endoplasmic reticulum membrane [GO:0005789] AGSGGHTT;LLGILGIKKVIIV;SALLLGILGIKKVII;VVAGSGGHTTEILR 4 13.9 1.0034 -1.701 0 3.36163 0 0 0 0 0 12.071 0 0 0 0 0 0 10.9452 A0A8I3NQR1 A0A8I3NQR1_CANLF HUWE1 associated protein modifying stress responses HAPSTR1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction by p53 class mediator [GO:1901797]; regulation of cellular response to stress [GO:0080135] cytoplasm [GO:0005737]; nucleus [GO:0005634] ubiquitin protein ligase binding [GO:0031625] EIQEHGPEHWFSKW;ETDLQPFREAIALH 2 10.2 0.90241 0.12189 0 0 0 8.61563 0 5.61909 0 0 0 0 0 0 0 0 0 A0A8I3NQR4 A0A8I3NQR4_CANLF Rho GTPase activating protein 12 ARHGAP12 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] EAKDRKIVIKQGERYILVK;ENESSPSSPKHQDTGQEKYG;EPIVLTKWRHSTIV;GIYRVSGNLAVIQKLRF;LDERGHTLYTSDYTNEKWLK;LFGHSPGPEFLDVEKT;QEKYGLLNVTKI;SLDLTHNNGKFNSD;TENGKKVRK 9 16.2 0.9944 -0.56121 0 6.84336 8.97525 0 8.5196 0 9.14149 10.366 8.147 0 0 8.85406 0 0 0 A0A8I3NQR5 A0A8I3NQR5_CANLF PRKR-like endoplasmic reticulum kinase EIF2AK3 Canis lupus familiaris (Dog) (Canis familiaris) response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694] ATESSVYLGMYRGQ;IKWKPLIHSPS;PPEKWQEKMDEIWLK;VGHFELRYIP;WDLDVGSGSLVSSSLSKPEVRYIC 5 7.1 1.0016 -0.69599 0 0 0 10.0445 0 0 10.3449 0 0 0 13.5135 0 11.1846 9.27006 0 A0A8I3NQS2 A0A8I3NQS2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CDC7 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GPAAPKELDQ;LVDFGLAQGTHDTK;RRQQVAPRAGT 3 6.4 0.98731 -0.36123 0 0 0 11.7112 0 7.72955 0 0 0 0 0 0 0 10.1514 0 A0A8I3NQT0 A0A8I3NQT0_CANLF LON peptidase N-terminal domain and ring finger 1 LONRF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] DVTLKIYRAE;GALEAYAA;PAPRGRGRFWEVGGGGGDR;PDVARSSPGGSR;SASELSPEQNEEVPEVT 5 9 0.95292 0.049829 9.35962 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQT6 A0A8I3NQT6_CANLF "Arachidonate 12-lipoxygenase, 12S type" LOC119871841 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; lipid oxidation [GO:0034440]; lipoxygenase pathway [GO:0019372] cytoplasm [GO:0005737] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165] CPTPMLPSNPPMAW;DDQSLFKTHREQEI;GIISRRYVEGMVGLF;KTALDDALFGYQFL;NGEALFPCYCWV;SVATMRTLPSL;VCLPEGTGEGGGATDDQSLF 7 16.3 0.93798 0.063575 0 0 0 0 7.3572 0 10.3114 0 0 13.5316 0 0 5.60463 0 11.8785 A0A8I3NQT7 A0A8I3NQT7_CANLF Adhesion G protein-coupled receptor A2 ADGRA2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] APKGAKYDDVSGADAAGGACM;CEGALELHTHHLIPS;EASRQGQRRSASRDNLRGGGGG;PEDGDGFYSPGVQL 4 6.4 0.80759 0.2148 9.13955 0 0 7.03199 7.1537 0 0 0 0 7.70404 0 0 0 0 8.93811 A0A8I3NQU3 A0A8I3NQU3_CANLF Fibrillin 2 FBN2 Canis lupus familiaris (Dog) (Canis familiaris) bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] extracellular region [GO:0005576]; microfibril [GO:0001527] calcium ion binding [GO:0005509] CLCYDGFMASMDMKTCIDVNE;CMNGGTCADDHCQCQ;CQGQLTGI;CTDIDECMIMNGGCD;DIDECSNGDNLCQRHAD;DMEERNCTDIDECR;DNGLCRNTPGSYSCTCPPGYVF;FTCSDVDECAENIN;GVCINQIGSF;GVSCEDVNECE;ICMNGHCINNEGSFRCDCPP;KFNLSGLGSKEHI;NTPGGFQC;QELPGRMT;QHYQWNQCVDENECSNPNACGSA;QTMCMDVDECER;RCECEMGF;SECCCDGGRGWGHQC;SVPLYKKKELKK;TGVRCVDTDECSIGNP;TQHHTACIDNNE;YRCNCNSGYEPDASGRNCID;YYCKCHAGFQRTPTKQA 23 11.4 0.99728 -3.8715 9.02592 6.18668 10.9692 0 8.86171 10.4172 0 0 9.40956 10.3664 6.97613 0 5.74927 11.4872 11.3746 A0A8I3NQU5 A0A8I3NQU5_CANLF Zinc finger protein 664 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DKGFFHISE;STSLCIHQRVH 2 7.7 0.99234 -0.27099 0 0 0 0 0 0 0 0 0 3.85788 0 0 0 0 5.09043 A0A8I3NQU7 A0A8I3NQU7_CANLF alanine transaminase (EC 2.6.1.2) GPT2 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] AAQDDHPPPGGEAEDRPAEG;LAAKAKLTEDLF;VYSPDCRFH 3 7.7 0.96432 0.048688 0 0 0 0 0 0 0 0 0 0 0 4.8266 0 0 0 A0A8I3NQU9 A0A8I3NQU9_CANLF Annexin ANXA13 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] LLEILKPTLKSQSYSL 1 4.6 0.96349 0.049233 5.76423 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQV4 A0A8I3NQV4_CANLF Uncharacterized protein LOC102157302 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCRDPCCCR;CCQPCCCRDPCCC;CGTECCQPCCC;CSSQGCGTECCQPCCC;ECCQPCCCRDPC;GTECCQPCCCRDPCCC;ICSSQGCGTECCQPCCCRDPCC;PCCCRPVSCQTTVCRPVT;PVCCDPCS;SCCGSICSSQGCGTECCQPCCCRDP;SQGCGTECCQPCCCRDPCC;TECCQPCCCRDPCCC 12 39.4 0.58182 0.36992 7.46312 0 5.32405 3.66494 7.06856 0 7.24375 0 5.0884 0 0 6.42139 5.34852 7.62015 5.59947 A0A8I3NQX4 A0A8I3NQX4_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (NADH-ubiquinone oxidoreductase B14 subunit) NDUFA6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981]; response to oxidative stress [GO:0006979] mitochondrial respiratory chain complex I [GO:0005747] ELEETINVWKQRTHVMRFFHE;PGAALAGGGFFG 2 22.4 0.98752 -0.2288 7.6494 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NQX6 A0A8I3NQX6_CANLF Zinc finger and BTB domain containing 12 ZBTB12 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] sequence-specific double-stranded DNA binding [GO:1990837] AEEEDEDEDEDVS;GATSGLVEA 2 4.8 1.004 -1.0831 0 0 0 0 0 0 0 0 0 0 0 8.82273 11.3815 0 11.2422 A0A8I3NQX8 A0A8I3NQX8_CANLF PHD and ring finger domains 1 PHRF1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EQPARPPASVGADASP;GAASLSLFGD;LDELVDRSPGPDG;LTGREGPGQPGHGAR;PLLRAKALVKRVTWN;PVPDLVGS;RRHRRAEAGEEAPAQ;RRKRRSRSPRSPS;SRLTGREGPG;YHMECLDPPLQ 10 7.3 1.0032 -1.9376 0 10.1253 9.13468 0 0 0 0 4.06824 0 8.63891 0 0 5.19672 3.42988 5.20828 A0A8I3NQY5 A0A8I3NQY5_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) NTRK1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; nervous system development [GO:0007399] plasma membrane [GO:0005886] ATP binding [GO:0005524]; neurotrophin receptor activity [GO:0005030]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] LTMLQHQHIVRFFGVCTEGRP;SLHFMTLGGSSL;TVTQSGDLPSL;VSESARQDFQ 4 7.3 0.99404 -0.12423 9.2974 9.51605 0 0 0 0 6.47319 0 0 0 0 0 0 0 9.43727 A0A8I3NQY7 A0A8I3NQY7_CANLF Uncharacterized protein LOC102151604 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCSYCCQPTC;CRPSYCGQSCCRPA;CSTSGNCGSSCCQPSCCQTSCCQP;QPTSCQTSCCQPTCCQTSCCQPSCG;SGNCGSSCCQPSCCQTSCCQPT;SSCCQPSCCQTSCCQ;STSGNCGSSCCQPSCCQTSCCQPT;TSCQTSCC;TSCQTSCCQPTCCQ;TSGNCGSSCCQPSCC 10 47 0.93234 0.096307 0 0 0 0 0 0 0 0 0 4.82563 0 0 0 7.16068 0 A0A8I3NQZ6 A0A8I3NQZ6_CANLF Rho related BTB domain containing 3 RHOBTB3 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteolysis [GO:0030162] cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625] ADVVFEIQGTTVPAHRA;CLSTWLLHFIAT;DCLSTWLLHFIATNYLIFSQ;FLEYLYTDSCC;SIHIVALG 5 9.2 1.0034 -1.5519 0 0 6.48959 0 9.38519 6.27268 0 0 7.88362 0 0 0 6.53699 0 0 A0A8I3NR04 A0A8I3NR04_CANLF TBC1 domain family member 8 TBC1D8 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] REFIQFCKTLYSMFHEDP;TLYSMFHEDPEENDL;TVCMFRTEKIR;VGSHHAFFSDDQE;YRLHIPPALTENDR 5 5.7 0.72531 0.25847 0 4.23619 10.9965 0 0 6.72683 0 8.61419 0 0 0 0 0 7.75054 0 A0A8I3NR09 A0A8I3NR09_CANLF Catechol-O-methyltransferase domain containing 1 COMTD1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] O-methyltransferase activity [GO:0008171] EVNPGPPELGRPLWR;QGDSMMTCEQAQLL 2 11.1 0.99077 -0.20963 0 9.68013 0 0 0 0 0 0 0 0 0 0 0 5.97824 0 A0A8I3NR15 A0A8I3NR15_CANLF Exoribonuclease 1 ERI1 Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047] cytoplasm [GO:0005737]; nucleolus [GO:0005730] 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676] DSYYDYICIIDFEATCEEG;KYKYCILTDGSWDMSKFLNIQCRL 2 12.3 0.99242 -0.55255 0 0 0 0 0 9.81575 9.40327 0 0 0 0 0 0 0 0 A0A8I3NR19 A0A8I3NR19_CANLF Sphingosine-1-phosphate receptor 4 S1PR4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189] mitochondrion [GO:0005739]; plasma membrane [GO:0005886] sphingosine-1-phosphate receptor activity [GO:0038036] LAAIMALYGA;YSFRSREVCQAV 2 5.7 0.988 -0.37428 10.2569 0 0 9.79917 0 0 0 0 0 9.87811 0 0 0 0 0 A0A8I3NR20 A0A8I3NR20_CANLF Neuronal PAS domain protein 4 NPAS4 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to corticosterone stimulus [GO:0071386]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; learning [GO:0007612]; long-term memory [GO:0007616]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission, GABAergic [GO:0032228]; short-term memory [GO:0007614]; social behavior [GO:0035176]" nucleus [GO:0005634]; postsynapse [GO:0098794]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GPASLFLAMFQ;GVSAFPYDGFTDEL;PEDLAHASAQHYRLLAESGDI;PENILSQEHC 4 7 0.9878 -0.46114 0 0 8.54786 0 0 0 0 0 10.2634 0 0 0 0 8.45791 0 A0A8I3NR33 A0A8I3NR33_CANLF 5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase) PRKAA2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; lipid droplet disassembly [GO:1905691]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; Wnt signaling pathway [GO:0016055] axon [GO:0030424]; cytoplasmic stress granule [GO:0010494]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleotide-activated protein kinase complex [GO:0031588] AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein serine/threonine/tyrosine kinase activity [GO:0004712] DEHVPTLFK;LFRHPHIIKLYQVISTPTDFFM;QNLKLFRH;VGKIKREIQNLKLFRHPHIIKL 4 7.8 1.0017 -1.8152 0 10.1362 7.90983 0 6.16976 0 0 0 0 0 0 7.3692 0 0 0 A0A8I3NR49 A0A8I3NR49_CANLF Heat shock factor-binding protein 1 HSBP1 Canis lupus familiaris (Dog) (Canis familiaris) axonal transport of mitochondrion [GO:0019896]; cellular heat acclimation [GO:0070370]; endodermal cell differentiation [GO:0035987] axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714] ADLMTQAGVEELEGENKIPATPK 1 30.3 0.97589 0.046453 6.2014 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NR50 A0A8I3NR50_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 2" AGAP2 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] AAELAHVVI;AATPSPRRRSSA;EGSAGQAEEENFEF;GAEPPAPA;LAAELAHVVI 5 3.8 1.0043 -1.0539 0 0 0 0 7.64875 0 2.22996 0 0 0 0 0 0 0 0 A0A8I3NR56 A0A8I3NR56_CANLF Oxidative stress responsive serine rich 1 OSER1 Canis lupus familiaris (Dog) (Canis familiaris) SPVLHPPKFIH;VTIEDLSGYMEYYLY 2 8.9 0.9362 0.089402 7.52795 0 0 0 0 0 0 0 9.2617 0 0 0 0 0 0 A0A8I3NR69 A0A8I3NR69_CANLF E2F transcription factor 3 E2F3 Canis lupus familiaris (Dog) (Canis familiaris) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; protein import into nucleus [GO:0006606] RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGG;HLIKKKSK;LLYTTPHGPSG;QDIRKISGLKDQTVI 4 9.1 0.99232 -0.17654 0 0 0 0 0 0 0 0 8.25319 0 9.87873 0 8.29389 0 0 A0A8I3NR82 A0A8I3NR82_CANLF ethanolamine kinase (EC 2.7.1.82) ETNK1 Canis lupus familiaris (Dog) (Canis familiaris) GVSDVDYSLYPDRQL 1 3.3 0.95321 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 9.61974 0 A0A8I3NRA1 A0A8I3NRA1_CANLF F-box protein 10 FBXO10 Canis lupus familiaris (Dog) (Canis familiaris) ESWREAFKQHYLAS;LSPSGEDEDEDQLTYR;NIIFQGKTSKTIFQQISNNRE;RWRQLCLECTE;TIFQQISNNRECILQNNKFL 5 7.7 0.98577 -0.42198 8.34505 5.37149 0 0 7.59089 0 9.30243 0 0 0 0 0 0 0 0 A0A8I3NRB5 A0A8I3NRB5_CANLF ARF7 effector protein C-terminal domain-containing protein ARL14EP Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] VGVQLRTTNECHKTYYTR 1 6.9 0.97464 0.048313 0 0 0 0 6.17911 0 0 0 0 0 0 0 0 0 0 A0A8I3NRB7 A0A8I3NRB7_CANLF Cleavage and polyadenylation specificity factor subunit 6 CPSF6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nuclear speck [GO:0016607] RNA binding [GO:0003723] DHSRSREKSRRHK;DYYRERSRERERHRDRDRDRDRERD;GVDHIDIYADVG;SRGPPPTDPYGRPPP;YYRERSRERERHRDRDRDRDRERD 5 11.8 0.99281 -0.17935 0 10.1861 0 0 0 10.2816 5.4933 9.45218 0 0 0 0 0 3.69031 0 A0A8I3NRC5 A0A8I3NRC5_CANLF Zinc finger protein 629 ZNF629 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DENLFVCSDCGKA;QESSGEEIILGDP;SGKPFKCPE 3 4 1.0021 -1.2697 8.17981 0 0 0 0 0 0 0 0 10.0997 0 0 0 0 0 A0A8I3NRC7 A0A8I3NRC7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK11 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; glucose homeostasis [GO:0042593]; positive regulation of vesicle transport along microtubule [GO:1901610]; regulation of cell growth [GO:0001558]; regulation of Wnt signaling pathway [GO:0030111]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activity [GO:0004674] AVKILKKKKLRRI;DLFDIEDDII;KILKKKKLRRI;KILKKKKLRRIP;KILKKKKLRRIPNGEANVK;LCRRAVKILKKKKLRRIP;RAVKILKKKKLRRIP;SETLCRRAVKILKKKKL;VKILKKKKLRRIP;VKILKKKKLRRIPN 10 9.4 0.99354 -0.17009 5.08096 0 5.9858 0 0 3.8518 0 4.21366 5.49665 0 0 3.40722 0 0 9.14029 A0A8I3NRD5 A0A8I3NRD5_CANLF UEV and lactate/malate dehyrogenase domains UEVLD Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211]; protein transport [GO:0015031] endosome [GO:0005768] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" ANMGISVGKHVDA;EKLQSSSSSIHDLQQ;KSVIVGLIKEM;LNFTGTIPVKYQGNT;NRVIGIGCN 5 14.7 0.99641 -0.10084 11.952 0 0 0 8.07756 6.82566 0 0 10.9249 0 0 0 0 0 0 A0A8I3NRD6 A0A8I3NRD6_CANLF Glutamate receptor GRIN2A Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane import into cytosol [GO:0097553]; directional locomotion [GO:0033058]; dopamine metabolic process [GO:0042417]; excitatory postsynaptic potential [GO:0060079]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; positive regulation of apoptotic process [GO:0043065]; protein catabolic process [GO:0030163]; protein localization to postsynaptic membrane [GO:1903539]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; serotonin metabolic process [GO:0042428]; sleep [GO:0030431]; startle response [GO:0001964]; visual learning [GO:0008542] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; NMDA selective glutamate receptor complex [GO:0017146]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021] glutamate-gated calcium ion channel activity [GO:0022849]; metal ion binding [GO:0046872]; NMDA glutamate receptor activity [GO:0004972] DIDPLTETCVRNTV;DSPKRAADFIQ;EARVRDGLGILTTAAYSMLEKFSY;NSMYSTPRVLNSCSNRRVY;PNENFRKGDPALPTNRNPTHNEDVL;RSLGLTGYDFFWIVPSLVS;SLITHVCDLMSG;SVWAFFAVIFLA;VAAENRTH;VHPRLVVIV;VHPRLVVIVL 11 10.5 0.99765 -3.3783 0 0 10.5928 0 0 0 0 4.22951 10.9209 7.4412 0 0 8.13489 10.8573 7.48148 A0A8I3NRE9 A0A8I3NRE9_CANLF SMEK homolog 1 PPP4R3A Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974] cytosol [GO:0005829]; nuclear speck [GO:0016607]; protein phosphatase 4 complex [GO:0030289] protein phosphatase activator activity [GO:0072542] EDEDKEDTLPLS;GLVDYPDDDEDDDEDE;HREFLTKT;LVDYPDDDEDDDEDEDKEDT;TLEDEEEMWFNT;YPDDDEDDDEDEDKED 6 5.4 0.73256 0.24755 0 0 8.48909 0 4.35931 8.44307 0 0 0 9.09064 4.03087 7.73715 0 4.05329 0 A0A8I3NRG8 A0A8I3NRG8_CANLF Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) Canis lupus familiaris (Dog) (Canis familiaris) translational elongation [GO:0006414] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] EESEESDDDM;VLELTCMAS 2 16.7 0.99092 -0.222 0 0 0 0 0 0 0 0 10.8994 0 0 0 0 0 0 A0A8I3NRH5 A0A8I3NRH5_CANLF Acrosomal vesicle protein 1 ACRV1 Canis lupus familiaris (Dog) (Canis familiaris) LKKIFEGGKLQ 1 3.9 0.98656 0.035491 6.62086 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NRH7 A0A8I3NRH7_CANLF Autophagy related 14 ATG14 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; mitophagy [GO:0000423]; negative regulation of protein phosphorylation [GO:0001933]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; positive regulation of protein phosphorylation [GO:0001934]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of macroautophagy [GO:0016241]; regulation of triglyceride metabolic process [GO:0090207]; response to mitochondrial depolarisation [GO:0098780] "autophagosome [GO:0005776]; axoneme [GO:0005930]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; phagocytic vesicle [GO:0045335]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]" GTPase binding [GO:0051020]; phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; protein-membrane adaptor activity [GO:0043495] DQLRWKIMSCKMRIEQ;GVAGESDESGD 2 5.3 0.94668 0.084724 0 0 0 4.03413 0 0 10.6651 0 0 0 0 0 0 0 0 A0A8I3NRH8 A0A8I3NRH8_CANLF Ig-like domain-containing protein CD8B Canis lupus familiaris (Dog) (Canis familiaris) regulation of immune response [GO:0050776] membrane [GO:0016020] coreceptor activity [GO:0015026]; MHC class I protein binding [GO:0042288] DVLPTTAQ;FLAFWDPKKGIVYD;GVLVLLVSLGVAIH;LGVAIHLHRLRRRARLRLL;LVAGVLVLLVSL 5 24.8 1.0019 -1.2683 0 0 8.57384 5.97237 8.54454 0 6.23852 0 0 0 0 0 0 0 0 A0A8I3NRI2 A0A8I3NRI2_CANLF Myosin XVIIIA MYO18A Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAIEDEMESDENEDL;EMESDENEDLITSEG;ERLFSYYGPQEGDKKGQR;GWLSYTKQNPA;HKDGFSLGSQLKSEELSLP;KKHELEMDLE;KQMEVQLEEEYEDKQ;QEFEDKLEVEQQ;RLEMEMERMRQTHSKEVE;TGMAAVKKKSL;VQLEEEYEDKQ 11 6.6 0.9509 0.053874 0 0 0 0 0 0 0 0 10.038 0 0 0 0 0 0 A0A8I3NRJ2 A0A8I3NRJ2_CANLF Uncharacterized protein SUZ12 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; random inactivation of X chromosome [GO:0060816] chromatin silencing complex [GO:0005677]; ESC/E(Z) complex [GO:0035098]; ribonucleoprotein complex [GO:1990904]; RSC-type complex [GO:0016586]; sex chromatin [GO:0001739] chromatin DNA binding [GO:0031490]; lncRNA binding [GO:0106222]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AAGAAVLPVKKPK;CGGGGSYSASSSSSAAAAA;DLNQTKPGNF;GGGGGGGSGP;GGGGGGSG;GGKSGGGG;KHGGGGGG;KVEKMKGE;LHVMKHGFIA 9 10.6 1.0008 -2.7373 0 0 9.94116 6.05376 0 13.3573 7.21965 0 0 10.2058 4.30597 0 0 0 0 A0A8I3NRJ8 A0A8I3NRJ8_CANLF Survival motor neuron SMN Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; nervous system development [GO:0007399]; RNA splicing [GO:0008380] Cajal body [GO:0015030]; Gemini of coiled bodies [GO:0097504]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; Z disc [GO:0030018] RNA binding [GO:0003723] FKKKKKKP;SWYMSGYHTGYYMGFKQNQKE;VGDKCSAVWSEDGC 3 14.1 1.0016 -0.99639 0 0 0 0 0 0 0 4.1534 0 0 0 0 5.09415 0 9.66926 A0A8I3NRK3 A0A8I3NRK3_CANLF Uncharacterized protein KLHL12 Canis lupus familiaris (Dog) (Canis familiaris) adiponectin-activated signaling pathway [GO:0033211] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023] KFDIWFQSHQI;QEFRYGLEGGCTDD 2 6.7 0.92924 0.096399 5.24039 0 0 0 0 5.58355 0 0 0 0 0 0 0 0 0 A0A8I3NRL4 A0A8I3NRL4_CANLF TATA box-binding protein-like 2 (TATA box-binding protein-related factor 3) TBPL2 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677] SGKVVLTGAKERSEI 1 4.4 0.97489 0.042504 0 0 14.031 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NRL7 A0A8I3NRL7_CANLF Zinc finger protein 143 ZNF143 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ENMEGVSLQAVTLADGSTAYIQ;ITYVTGVE 2 4.9 0.98651 -0.45583 0 0 0 0 9.24184 0 0 0 0 0 0 0 0 0 0 A0A8I3NRM9 A0A8I3NRM9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AESPLFFFNFLFIHERHTERES;GPKAGAKP;KQLVVQEALLTILREL;LPVDDKFPVLSLDCAVEFA 4 20.8 0.99223 -0.17959 0 0 0 8.40361 0 0 0 5.95678 0 0 0 0 0 0 0 A0A8I3NRN0 A0A8I3NRN0_CANLF Periplakin PPL Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104]; wound healing [GO:0042060] cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; membrane [GO:0016020] structural molecule activity [GO:0005198] EEERHRRQVL;KQKEEELSHVK;LEEERHRRQVL;PQQAREHALLKVQL;YMQRCTNEL;YVLEADAAIAK 6 3.4 1.004 -1.1018 0 0 10.6394 0 0 0 9.81818 0 0 0 8.15558 0 13.7536 15.1463 0 A0A8I3NRP0 A0A8I3NRP0_CANLF Zinc finger protein 385A ZNF385A Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AEAHYKGNRHARR;DGSGRGLPAVPAPRPGRASPP;PPLAPPGP;TPSPPRATPHLQPGPRP;VPAPRPGRASPPGTAH 5 13.5 0.98685 -0.35596 13.4846 13.3937 0 8.52689 0 0 13.4814 13.3833 13.6898 0 0 0 0 9.91421 0 A0A8I3NRQ0 A0A8I3NRQ0_CANLF Metallophosphoesterase domain containing 1 MPPED1 Canis lupus familiaris (Dog) (Canis familiaris) KKFNEWLGRCWAGGGLA;PGYTRFVCVSDTHSRTDPIQ 2 19.4 0.99365 -0.07491 0 0 0 10.9134 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NRQ7 A0A8I3NRQ7_CANLF Dynein axonemal heavy chain 8 DNAH8 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AVIRQYNKISY;EAKLTQVIENWTNQNLSF;FYPGVAEHKDISKL;HPGGGRNDIPQRLKRQFTVFN;IEEAYAIL;ILNTLIAQTTHDL;INHTIERILQYY;KLKNFYPGVAEH;LDPLSFLIN;LINDLFPGLQLDSSTYVELQ;LKGTESGEIITLMEDSL;LKNKDDIEDIC;LTGEQGTAKTVMVKAYMK;LVPSFDFLSEKLQFYQR;PENLKIQFRT;PFRWILDMTWLNLVE;RCLGKYVV;SMQQCSKPLSL;SYLSFINGYKNIYTEKVKHINEQA;VHVWDQETPIVLKKIQDCIFLFKEY;VLHKTRKELNLLQK;VPEQAKKLLKLESKLKA 22 7.6 0.53804 0.4355 0 0 0 0 0 0 11.3337 0 0 0 0 11.2982 10.552 0 0 A0A8I3NRR5 A0A8I3NRR5_CANLF Adaptor related protein complex 5 subunit sigma 1 AP5S1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197] AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; nucleoplasm [GO:0005654] ESMCRLQQQASG;LVRLLLDHLRLLTPSAN 2 14.5 0.9918 -0.18007 0 10.043 0 0 0 0 0 5.52184 0 0 0 0 0 0 0 A0A8I3NRR9 A0A8I3NRR9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] RTKIDRLMNRLVVL;SDRIVNNRPCQI 2 7.4 0.99086 -0.19515 0 0 0 0 0 0 0 9.99591 14.7314 0 0 0 0 0 0 A0A8I3NRT9 A0A8I3NRT9_CANLF ribulose-phosphate 3-epimerase (EC 5.1.3.1) RPE Canis lupus familiaris (Dog) (Canis familiaris) "carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]" cytosol [GO:0005829] D-ribulose-phosphate 3-epimerase activity [GO:0004750]; metal ion binding [GO:0046872] IVSGSAIMRSDDPRSV;VGLAIKPG 2 12.1 1.0023 -1.271 0 0 0 0 0 7.75034 0 0 0 0 0 0 9.74525 3.7721 8.37808 A0A8I3NRU0 A0A8I3NRU0_CANLF Vinculin LOC102154778 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737] actin filament binding [GO:0051015] EEGASEAVAVNS;EIPTSAPSG;EVLLMAQSLRKRGPIL;PAADLPGNMAVFIELQQNLASVV;PSEEMAVMKPRG;STRFELLYL 6 5.6 0.99003 -0.22215 0 0 0 0 0 0 0 9.95524 0 3.06963 9.70627 0 0 0 0 A0A8I3NRW9 A0A8I3NRW9_CANLF Mineralocorticoid receptor (Nuclear receptor subfamily 3 group C member 2) NR3C2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] DLVSDLLEFC;DYTYDQQNQQGS;LVSDLLEFCF;NEEKMHQSAMYELCQGMHQI;QEVPFPKSEEVENAISNGVTGQL;YDSSKPDTAENLL 6 8.3 1.0018 -1.2626 10.7912 0 0 9.53986 0 3.26282 8.01853 0 0 0 9.58991 0 0 0 0 A0A8I3NRX5 A0A8I3NRX5_CANLF Uncharacterized protein LOC102151492 Canis lupus familiaris (Dog) (Canis familiaris) GAIFTDMKV 1 2 1.0044 -0.80421 0 0 6.87946 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NRY5 A0A8I3NRY5_CANLF Olfactory receptor OR1K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AHDRSISLAGCLTQMY;FFFALGVTD 2 7.9 1.0029 -0.75498 0 9.50575 0 9.94438 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NRZ3 A0A8I3NRZ3_CANLF Exosome component 3 EXOSC3 Canis lupus familiaris (Dog) (Canis familiaris) "CUT catabolic process [GO:0071034]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]" cytoplasmic exosome (RNase complex) [GO:0000177]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730] RNA binding [GO:0003723] EPGGGSGGGV;GVYWVDSQQKRY 2 12.2 0.93814 0.063301 0 0 0 0 8.12707 0 0 0 8.0926 0 0 0 0 0 0 A0A8I3NRZ6 A0A8I3NRZ6_CANLF Transglutaminase 3 STK35 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ELALAEFWALTSLKRRHQN;QGTEIVPVGEALL;VGEALLENP 3 6.5 0.94948 0.049977 8.11014 6.27001 0 0 0 0 8.40977 0 0 0 0 0 0 0 0 A0A8I3NS03 A0A8I3NS03_CANLF KIAA1143 KIAA1143 Canis lupus familiaris (Dog) (Canis familiaris) INNQDSVKK 1 5.8 0.98965 -0.19655 0 0 0 0 0 9.82416 0 0 0 0 0 0 0 0 0 A0A8I3NS04 A0A8I3NS04_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MIB2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] early endosome [GO:0005769]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DWKWGQQDGGEGGV;DWKWGQQDGGEGGVG;GAAVACFLALEGADVSYANHR 3 4.8 0.9932 -0.061408 10.8183 13.8444 9.55474 11.4831 0 12.6685 13.56 15.4902 13.5906 16.3091 0 15.8956 5.60532 0 0 A0A8I3NS05 A0A8I3NS05_CANLF Chromosome 2 open reading frame 78 C2orf78 Canis lupus familiaris (Dog) (Canis familiaris) LVSSSNPKDARPSPA;TASLTGSV 2 3.6 0.99228 -0.5418 0 0 0 0 0 0 0 0 10.4674 0 9.18772 0 0 0 0 A0A8I3NS08 A0A8I3NS08_CANLF Switching B cell complex subunit SWAP70 SWAP70 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] QVAQKSSELEQYLQRVRELEDMYLK 1 4.7 0.97998 0.035538 0 0 10.1697 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NS11 A0A8I3NS11_CANLF Chromobox 2 CBX2 Canis lupus familiaris (Dog) (Canis familiaris) development of primary sexual characteristics [GO:0045137]; negative regulation of transcription by RNA polymerase II [GO:0000122] euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; PRC1 complex [GO:0035102] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064] LSKRLRKGKLEY;PGARQNPSVS;TSSSTSSDEEDD 3 6.4 0.99117 -0.51314 0 0 0 0 0 0 0 0 11.9605 3.58436 0 0 0 0 0 A0A8I3NS21 A0A8I3NS21_CANLF Cysteine rich transmembrane BMP regulator 1 CRIM1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] CFTAQCGEL;CGCCYMCA;CPLGFQQDSHGCLI;CYCHNGREMC;EDDCTFCQC;EDSVLIEGYAPPG;EYNDGDMFRMDNCRFCRC;FYSMQKQNHLQ;GVCEEEKPDCSKAR;GVCGCCYMCARQRNESCGG;HFSGKAYADEERWDIDSCTHCYCL;PDVCTSCVCMDS;SWHDGCRECYCH;VICDKYCPFGYLK;VIRPPLNGDSITEY;VLRKGQCCPYCIED 16 20.6 0.93317 0.060826 0 0 0 0 0 0 0 8.3041 0 0 0 0 0 0 0 A0A8I3NS26 A0A8I3NS26_CANLF Nicotinate phosphoribosyltransferase (EC 6.3.4.21) (Nicotinate phosphoribosyltransferase domain-containing protein 1) NAPRT Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] nicotinate phosphoribosyltransferase activity [GO:0004516] MDCCSHPL;QELRVWPHGAREA;QEPHRGERAAF 3 4.7 1.0037 -1.1044 9.38195 0 0 0 0 0 9.36304 0 0 0 0 0 0 0 0 A0A8I3NS40 A0A8I3NS40_CANLF Structural maintenance of chromosomes 6 SMC6 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697] DKDGDEDEC;EEFLRRRQIHYRELKVK;ILSLWSIAESPFRCLDEFDVYMICL;KVRTLKRFIKLL;LDNKVRTLKRFIKLL;RKEELIAILDH 6 7.4 0.98778 -0.35292 7.59171 0 0 6.80555 0 0 5.8525 0 0 2.40591 0 0 0 0 9.88266 A0A8I3NS44 A0A8I3NS44_CANLF Calcium dependent secretion activator 2 CADPS2 Canis lupus familiaris (Dog) (Canis familiaris) dense core granule exocytosis [GO:1990504]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytoplasmic vesicle [GO:0031410]; presynapse [GO:0098793] KDADRFQKHGM;MAKERNFPKF;PSLPLTLPQ;YETLHRRL 4 3.2 1.0032 -2.1389 0 0 11.2256 6.68832 0 6.05515 9.45555 0 0 0 0 0 0 0 0 A0A8I3NS46 A0A8I3NS46_CANLF Mitotic deacetylase associated SANT domain protein MIDEAS Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EVTPPVLSVMGEATPVSIEP;GVLPSAPLDVAGTQPGQEPTSN;HESRGDILETLN;LHCLHESRGDI;QEPAPKEQPAPLQAPQQ 5 7.3 0.2377 0.72792 9.97298 0 0 0 0 0 0 9.93951 10.0125 9.61399 0 11.3449 0 0 9.67191 A0A8I3NS47 A0A8I3NS47_CANLF Bifunctional apoptosis regulator BFAR Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] ubiquitin protein ligase activity [GO:0061630] EVRQLETQ;GVKPPQNLWEYKA;SEFSCHCCYD 3 9.5 0.98767 -0.34859 0 8.66761 0 0 0 0 0 0 0 0 0 5.76832 0 0 0 A0A8I3NS48 A0A8I3NS48_CANLF "ASH2 like, histone lysine methyltransferase complex subunit" ASH2L Canis lupus familiaris (Dog) (Canis familiaris) Set1C/COMPASS complex [GO:0048188] transcription cis-regulatory region binding [GO:0000976] IPGDLYRACLY 1 2.2 0.97883 0.035491 0 0 0 0 0 0 0 0 7.3015 0 0 0 10.4581 0 10.387 A0A8I3NS51 A0A8I3NS51_CANLF Integrin subunit alpha L ITGAL Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; receptor clustering [GO:0043113]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] cell surface [GO:0009986]; integrin alphaL-beta2 complex [GO:0034687] cell adhesion molecule binding [GO:0050839]; ICAM-3 receptor activity [GO:0030369]; metal ion binding [GO:0046872] ESKDKEHWSQIQKIDGNQI;FPVCIQDL;FSLWEEEETPRNKR;IDQDGETELLLIGAP;LRGVVLQGRPG;VGNEPLTPEAR 6 6.7 1.0016 -0.74742 12.7395 0 0 0 0 0 0 0 0 9.90366 0 9.53974 10.182 8.02686 7.34305 A0A8I3NS55 A0A8I3NS55_CANLF Olfactory receptor OR2A9B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KPLIYSLRNA;VMYMVPKSRHPEEQQK 2 8.4 0.98998 -0.21378 0 8.09424 0 0 0 0 0 7.39043 0 0 7.95455 0 0 0 0 A0A8I3NS64 A0A8I3NS64_CANLF Zinc finger with KRAB and SCAN domains 4 LOC100685048 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DECEECGK 1 1.6 0.98476 -0.25935 10.5104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NS71 A0A8I3NS71_CANLF Centromere protein I CENPI Canis lupus familiaris (Dog) (Canis familiaris) centromere complex assembly [GO:0034508] kinetochore [GO:0000776]; nucleus [GO:0005634] INCVKDESI;NMRSIRGKKWNWYLDYLFSEG;NRAQCFLQEGFYSC;NWYLDYLF;SPLETTLG;VKPFRVRK 6 8.7 1.0032 -2.2836 0 10.9851 0 0 8.06566 0 0 6.93687 9.22407 0 0 0 0 0 0 A0A8I3NS72 A0A8I3NS72_CANLF Src kinase-associated phosphoprotein 1 SKAP1 Canis lupus familiaris (Dog) (Canis familiaris) CEDEEEEEEEEE;LSSLTIPCEDEEEEEEEEE 2 5.5 0.9373 0.099884 0 0 0 0 4.95345 6.41458 0 0 0 0 0 0 0 0 0 A0A8I3NS74 A0A8I3NS74_CANLF Fibroblast growth factor receptor 3 (EC 2.7.10.1) FGFR3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; fibroblast growth factor receptor apoptotic signaling pathway [GO:1902178]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transport vesicle [GO:0030133] ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; identical protein binding [GO:0042802] DLYMIMRECWHA;EPQVSKAL;PSSGDDEDGEDE;PSSGDDEDGEDEAEDTGAPYWTR;SGDDEDGEDEAEDTGA;SLMGCSSKWREEG;YSCRQRLTQR 7 6.7 1.0032 -0.86746 0 0 0 7.87615 0 5.46907 6.27545 0 0 5.40824 0 0 10.257 0 7.98687 A0A8I3NS83 A0A8I3NS83_CANLF RAB11 family interacting protein 4 RAB11FIP4 Canis lupus familiaris (Dog) (Canis familiaris) cleavage furrow [GO:0032154]; midbody [GO:0030496]; recycling endosome membrane [GO:0055038] DCAPSSPCPDD;EEEARRHRE;ISNEEQFEDYGEGDDVDCAP;SSSGLGEF;THSTTSLISNEEQFEDYGE 5 9.6 1.0017 -1.2851 0 0 0 6.58715 0 0 0 6.53989 0 0 0 10.969 4.97058 0 0 A0A8I3NS93 A0A8I3NS93_CANLF Oxysterol-binding protein OSBP Canis lupus familiaris (Dog) (Canis familiaris) ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; phospholipid transport [GO:0015914]; sphingomyelin biosynthetic process [GO:0006686] cell junction [GO:0030054]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] phosphatidylinositol-4-phosphate binding [GO:0070273]; protein domain specific binding [GO:0019904]; sterol binding [GO:0032934]; sterol transfer activity [GO:0120015] IITMPENLG;LGETFELD;SNGGAQTYHLKASSEV;VAAAGPAP 4 5.1 1.003 -2.1597 0 0 9.71867 0 0 0 0 0 0 0 0 9.95029 0 8.01251 0 A0A8I3NS97 A0A8I3NS97_CANLF Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) HACD1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid elongation [GO:0030497]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum membrane [GO:0005789] 3-hydroxyacyl-CoA dehydratase activity [GO:0018812] KPIRFLGHIC 1 4 0.99884 -0.61146 0 0 0 0 0 8.79077 0 0 0 0 0 0 0 0 0 A0A8I3NSA0 A0A8I3NSA0_CANLF Endothelin-1 receptor (Endothelin receptor type A) EDNRA Canis lupus familiaris (Dog) (Canis familiaris) developmental pigmentation [GO:0048066]; enteric nervous system development [GO:0048484]; regulation of blood pressure [GO:0008217]; vasoconstriction [GO:0042310] plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962] IYQNKCMRNGPNALIA;KFKNCFQSCLCCCC;SLMTSVPM;VISCTIFIVG 4 15.1 1.0022 -1.4417 0 0 0 0 0 8.91925 0 0 9.78655 0 0 0 0 6.39719 0 A0A8I3NSA2 A0A8I3NSA2_CANLF Uncharacterized protein LOC100682875 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758]; metal ion binding [GO:0046872] DKKNSIEAVWHDESHLNKYFFLH;IILLLLLLLLLWILHR;KIILLLLLLL;KIILLLLLLLL;KIILLLLLLLLLWI;KIILLLLLLLLLWIL;KYGLETLGESVAQLHAYW;KYRRKIILLLLLLL;KYRRKIILLLLLLLLLWILHRQHRF;LLLLLLLL;LLLLLLLLL;LLLLLLLWILH;RKIILLLLL;RKIILLLLLLLL;RKIILLLLLLLLLWIL;RKIILLLLLLLLLWILHRQ;RRKIILLLLLLLLL;RRKIILLLLLLLLLW;RRKIILLLLLLLLLWIL;RRKIILLLLLLLLLWILH;SEHVVNHIQYEVDFL;YRRKIILLLLLLLLLWIL 22 24.5 1.0016 -1.4094 11.0081 9.67165 11.142 9.98442 8.97908 7.21306 9.14675 8.72962 7.71596 6.16124 10.4586 5.86819 12.2489 11.7803 11.4003 A0A8I3NSA4 A0A8I3NSA4_CANLF DNA-directed RNA polymerase II subunit E (RPB5 homolog) POLR2E Canis lupus familiaris (Dog) (Canis familiaris) "RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]" DNA binding [GO:0003677]; RNA polymerase I activity [GO:0001054]; RNA polymerase II activity [GO:0001055]; RNA polymerase III activity [GO:0001056] TIMQLCHDRGY 1 6 0.98278 -0.24811 0 9.6949 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSA8 A0A8I3NSA8_CANLF ATP-dependent DNA helicase (EC 5.6.2.4) RECQL Canis lupus familiaris (Dog) (Canis familiaris) DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA replication [GO:0006260] nucleus [GO:0005634] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] HVITMQMKKPT;VLQNIFKLQRFRLLQL 2 4.4 0.98409 -0.24743 0 0 8.13525 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSB1 A0A8I3NSB1_CANLF Olfactory receptor OR5A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AQFFFFVSMG;LVTLAWNLALIFL;SHLMVVTLLFGTALFMYL 3 12.9 0.99143 -0.13615 0 0 0 0 0 0 0 0 0 9.41232 0 0 0 11.742 7.95774 A0A8I3NSB4 A0A8I3NSB4_CANLF Limbic system associated membrane protein LSAMP Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] TEEHYGNYTCVAA 1 4.2 0.98998 -0.26572 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14.9241 A0A8I3NSB9 A0A8I3NSB9_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; wound healing [GO:0042060] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament [GO:0005882]; membrane [GO:0016020] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; structural molecule activity [GO:0005198] DISEIQSVCSDVET;EDCYVPQRSIYD;ELRDKWDTICGK;IDELVKSGHKIMAT;MVRVGGGWMALDEFLVKNDPCR;SAETIDQDLNNLKEKW;SLSSAEDIHIAEQYRP;TQKVEEIDAAILRSQQFD;VDIAGGKLASMSP 9 5.1 0.93328 0.099673 0 4.91609 0 0 0 0 0 0 0 0 0 5.97838 0 0 0 A0A8I3NSD9 A0A8I3NSD9_CANLF Myosin light chain kinase 3 MYLK3 Canis lupus familiaris (Dog) (Canis familiaris) cardiac myofibril assembly [GO:0055003]; cellular response to interleukin-1 [GO:0071347]; regulation of vascular permeability involved in acute inflammatory response [GO:0002528]; sarcomere organization [GO:0045214] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; calmodulin-dependent protein kinase activity [GO:0004683]; myosin light chain kinase activity [GO:0004687] GVHYLHQHY;KDREDVKNEVNIMNQLSHV;TDMWSVGVITYMLLSGLS 3 6 0.99142 -0.20906 0 0 0 0 4.93758 0 0 0 0 0 0 0 0 0 9.49659 A0A8I3NSG4 A0A8I3NSG4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" Lsm1-7-Pat1 complex [GO:1990726]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] RNA binding [GO:0003723] ITRLVPGGEGPEV 1 23.2 0.99008 -0.26572 0 0 8.47707 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSG8 A0A8I3NSG8_CANLF PHD finger protein 5A PHF5A Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; precatalytic spliceosome [GO:0071011]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686] VAIGRLCEKCDGKCVI 1 14.5 0.9634 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.00437 A0A8I3NSH8 A0A8I3NSH8_CANLF Homeobox protein PITX1 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APAAVPASMD;QELEATFQ 2 5 0.9984 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.73802 A0A8I3NSI0 A0A8I3NSI0_CANLF Uncharacterized protein TRMT9B Canis lupus familiaris (Dog) (Canis familiaris) gene expression [GO:0010467]; methylation [GO:0032259] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA methyltransferase activity [GO:0008175] ENGFYNTLGK;EQCPSKRSHSMDYEPLM;EQNLDEDVFVE;FSDSSQPG 4 10.2 1.002 -1.2793 0 10.3878 0 0 0 8.04723 8.20085 0 0 9.63887 7.29066 0 0 0 0 A0A8I3NSI2 A0A8I3NSI2_CANLF Cysteine rich transmembrane BMP regulator 1 CRIM1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoblast differentiation [GO:0045668] extracellular region [GO:0005576] PDZ domain binding [GO:0030165]; serine-type endopeptidase inhibitor activity [GO:0004867] CFTAQCGEL;CGCCYMCA;CPLGFQQDSHGCLI;CYCHNGREMC;EDDCTFCQC;EDSVLIEGYAPPG;EVGVCEDE;EYNDGDMFRMDNCRFCRC;FYSMQKQNHLQ;GVCEDENWDDD;GVCEDENWDDDQ;GVCEDENWDDDQL;GVCGCCYMCARQRNESCGG;HFSGKAYADEERWDIDSCTHCYCL;PDVCTSCVCMDS;SWHDGCRECYCH;VICDKYCPFGYLK;VIRPPLNGDSITEY;VLRKGQCCPYCIED 19 19.6 0.99699 -4.0338 8.58755 0 6.19529 0 7.19584 0 0 10.4098 10.6255 0 0 0 5.87887 6.2513 13.2035 A0A8I3NSJ0 A0A8I3NSJ0_CANLF Stimulator of chondrogenesis 1 SCRG1 Canis lupus familiaris (Dog) (Canis familiaris) mesenchymal stem cell proliferation [GO:0097168] Golgi apparatus [GO:0005794]; neuron projection terminus [GO:0044306] GVADLTKMDVNIQD 1 14.3 0.99385 -0.12105 0 0 0 0 0 0 0 0 12.0982 0 0 0 0 0 0 A0A8I3NSJ4 A0A8I3NSJ4_CANLF LRRC8 pannexin-like TM region domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALFEKVSK;KALFEKVSK;VCLPVFDISFGASAVTPDI 3 10.9 1.0019 -1.2642 0 0 0 0 0 0 0 9.64753 0 0 0 9.14448 0 0 0 A0A8I3NSJ7 A0A8I3NSJ7_CANLF Carboxypeptidase Q (Plasma glutamate carboxypeptidase) CPQ Canis lupus familiaris (Dog) (Canis familiaris) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; metallodipeptidase activity [GO:0070573]; protein homodimerization activity [GO:0042803] ADYFRRKTNW;LVSGHLDSWD;SERKVDPSDE;YPIDDDDYASASGSGADEDGES 4 8.3 1.0022 -1.2229 0 0 0 9.21233 0 0 7.24108 0 0 0 0 0 0 0 0 A0A8I3NSJ9 A0A8I3NSJ9_CANLF "Fidgetin, microtubule severing factor" FIGN Canis lupus familiaris (Dog) (Canis familiaris) nuclear matrix [GO:0016363] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AAGYPPQAAVGAGYSP;AALVPGYNGASNLAGYSYPA;DEPLKGAEPH;DIAGLDLVKAVLKEEVLWP;DWGDIAGLDLVKAVLK;GARPGGDSFGKYPS;GGGGGGGG;GGGGGGSG;GVAPALPPADASASIGSSPGVAS;IDESLRRYFMKRLLIPL 10 17.7 0.99661 -0.57747 8.18903 10.8517 5.8524 0 0 0 0 0 0 0 0 5.06987 0 7.69877 0 A0A8I3NSK3 A0A8I3NSK3_CANLF Hexosyltransferase (EC 2.4.1.-) CHPF2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] CHGGFGYLLSRSL;DSLGIGCVSQHQG;LNGYRRFDPA;VHFQEFNPALAPQRSPP;WIQGEGED 5 8.2 1.0025 -0.73837 0 0 8.67828 10.6538 0 0 0 0 6.77426 0 9.39693 0 0 0 0 A0A8I3NSL2 A0A8I3NSL2_CANLF Limb development membrane protein 1 LMBR1 Canis lupus familiaris (Dog) (Canis familiaris) embryonic digit morphogenesis [GO:0042733] MPFAFFFLE;SLYDLWEFYL;VDYNIMDLEQEL;VLSSALPVMSRTL 4 8.7 1.0023 -1.0027 0 0 8.89188 0 0 0 0 7.70515 0 0 0 0 0 0 12.5161 A0A8I3NSL4 A0A8I3NSL4_CANLF Protein LIAT1 LIAT1 Canis lupus familiaris (Dog) (Canis familiaris) non-membrane-bounded organelle assembly [GO:0140694] nucleolus [GO:0005730] molecular condensate scaffold activity [GO:0140693] EVSKRKVKKKKKKKT;EVSKRKVKKKKKKKTKG;KKKKKKKTKGPGKG;KRKVKKKKKKKTKGPGKGDA;KVKKKKKKKTKGPGK;KVKKKKKKKTKGPGKGDAD;QLSSSFHDILSPGKDHGPRQEHKQ;RKVKKKKKKKTKGPGK;SKRKVKKKKK;SKRKVKKKKKK;SKRKVKKKKKKKTKGPGKG;VSKRKVKKKKKKKT;VSKRKVKKKKKKKTK;VSKRKVKKKKKKKTKGPGKG 14 20.7 0.59155 0.37626 0 0 5.71337 7.69523 0 0 5.09803 6.73958 0 7.76613 0 5.88274 9.5611 7.48212 9.75148 A0A8I3NSM2 A0A8I3NSM2_CANLF RRM domain-containing protein SFPQ Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; regulation of DNA-templated transcription [GO:0006355]; rhythmic process [GO:0048511]" nucleus [GO:0005634] RNA binding [GO:0003723] ATPPTSGAPAGPGPTPTP;GPGGPKGG;GPKPGGGP;PGGPKPGG;PGPGQGGPKPPI;PMGPGPGQ;RGGGGGGF;VGSAPPASGSAPPATPPTSGAP;VIVEPLEQLDDEDGLPE;YHEHQANLLRQDLMRRQE 10 16.3 0.99681 -4.531 12.8985 0 7.88716 11.2246 11.2133 0 12.2596 11.6111 12.3332 10.2542 0 12.3311 10.3066 11.5619 10.4721 A0A8I3NSM7 A0A8I3NSM7_CANLF MIER family member 2 MIER2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991] histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826] ESRHPVCWGAPPAA;GLTADCLGAESSDM 2 5 0.996 -0.5706 0 0 0 0 0 0 0 0 0 0 0 0 8.72151 0 0 A0A8I3NSM8 A0A8I3NSM8_CANLF Keratin 40 KRT40 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] APATSRCQTPSFL;NCAWCEDGVFNSNEK;SDCFPTCCSS;VGNCAWCEDG 4 9.3 1.0022 -0.90363 0 0 0 0 0 0 0 8.70546 0 0 0 0 0 0 0 A0A8I3NSN2 A0A8I3NSN2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrion [GO:0005739] QDNRNLKMQLCQELHE 1 32.7 0.96138 0.049233 0 6.76514 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSP2 A0A8I3NSP2_CANLF Myogenin MYOG Canis lupus familiaris (Dog) (Canis familiaris) cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of cell population proliferation [GO:0008285]; ossification [GO:0001503]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber development [GO:0048743]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; skeletal muscle fiber development [GO:0048741]; striated muscle atrophy [GO:0014891] nucleoplasm [GO:0005654] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" LTSIVDSITVEDV 1 5.8 0.93821 0.059702 8.23117 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSQ0 A0A8I3NSQ0_CANLF DNA-directed RNA polymerase subunit (EC 2.7.7.6) POLR3A Canis lupus familiaris (Dog) (Canis familiaris) nuclear lumen [GO:0031981]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; RNA polymerase III activity [GO:0001056] CTPYNADFDGDEMNLHLPQ;DLCVNDSSN;FILVKLSLERIRLLRLEVNAETVRY;LDYLKRPG;LTRLLVPPLCI;PTILKPVTLWTGKQIFSVILRPS 6 7.1 1.0024 -1.8718 4.60822 0 3.73985 0 0 0 0 0 0 13.6889 0 0 0 7.68755 0 A0A8I3NSR5 A0A8I3NSR5_CANLF Translocator protein (Peripheral-type benzodiazepine receptor) TSPO Canis lupus familiaris (Dog) (Canis familiaris) establishment of protein localization to mitochondrion [GO:0072655]; lipid transport [GO:0006869]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of mitophagy [GO:1901525]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of reactive oxygen species metabolic process [GO:2000379] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966] cholesterol binding [GO:0015485]; transmembrane transporter binding [GO:0044325] PWVPAVGFTLVPSL 1 8.3 0.98947 -0.20284 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1407 0 A0A8I3NSR8 A0A8I3NSR8_CANLF Phospholipid phosphatase related 5 PLPPR5 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] LYSLAAGVPVLVIIVGETAVFCL;NEHIHMDNLAQMPMISIPRVESPLE 2 15.1 0.94521 0.081817 0 8.88417 0 0 0 0 0 9.1721 0 0 0 0 9.73559 0 0 A0A8I3NSS0 A0A8I3NSS0_CANLF Solute carrier organic anion transporter family member SLCO4A1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] CQRKPLLLVFIFVVII;GGQKVYRDCSCVPQ;SHSGSLLPDG;SPVYIATF;TVNGFINTVITSIERRYD 5 8.4 1.0018 -1.3198 8.61629 0 0 0 8.07895 6.02117 0 0 0 0 0 0 1.88178 0 0 A0A8I3NST6 A0A8I3NST6_CANLF Ubiquitin-like domain-containing protein IQUB Canis lupus familiaris (Dog) (Canis familiaris) IDEIRKKYHSE;WIKLDYYRRHN 2 3.2 0.99128 -0.13685 0 10.2075 0 0 10.07 0 0 10.3092 0 0 0 0 0 0 0 A0A8I3NSU3 A0A8I3NSU3_CANLF C1q and TNF related 1 C1QTNF1 Canis lupus familiaris (Dog) (Canis familiaris) HYAAFSVGRKKPLHSN 1 5.8 0.96024 0.049233 0 0 0 0 5.28718 0 0 0 0 0 0 0 0 0 0 A0A8I3NSV0 A0A8I3NSV0_CANLF Glyoxylate and hydroxypyruvate reductase GRHPR Canis lupus familiaris (Dog) (Canis familiaris) glyoxylate metabolic process [GO:0046487] catalytic complex [GO:1902494]; cytoplasm [GO:0005737] glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803] AADCEVEQWDSD;QPRPQEAAEFQAEFVSTPKLAAES;VGYTPDVLTDA 3 14.3 0.98976 -0.19934 0 0 0 0 6.383 0 9.72182 0 0 0 0 9.14374 0 0 0 A0A8I3NSW9 A0A8I3NSW9_CANLF Ecotropic viral integration site 2A EVI2A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EHRWLYLHLTLLMTI 1 6.5 0.98786 -0.2278 0 0 0 0 0 0 0 0 0 0 0 0 9.28223 0 0 A0A8I3NSX0 A0A8I3NSX0_CANLF "Calcium-activated potassium channel subunit beta (BKbeta) (BK channel subunit beta) (Calcium-activated potassium channel, subfamily M subunit beta) (Charybdotoxin receptor subunit beta) (K(VCA)beta) (Maxi K channel subunit beta) (Slo-beta)" KCNMB3 Canis lupus familiaris (Dog) (Canis familiaris) detection of calcium ion [GO:0005513]; neuronal action potential [GO:0019228] voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459] ALIVGMVRLTQY;DDWMDCAFIC 2 7.8 1.0032 -0.8865 0 12.1669 5.8953 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NSX3 A0A8I3NSX3_CANLF Glyceraldehyde 3-phosphate dehydrogenase catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" TQKTVDGPSGKLWC;VLSMLWSPLGSSPPWRRL 2 20.1 0.98485 -0.24677 0 0 0 0 0 6.82579 0 0 0 0 0 0 0 0 0 A0A8I3NSY4 A0A8I3NSY4_CANLF CD5 molecule CD5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FCPEEKLSQCHQLQERKTYCRRV;LVKKFRQKKQRQ;VENEYSQPPRNS;VLCDVPRAKGTAR 4 12.2 0.80048 0.20766 0 0 0 0 4.40722 0 0 0 0 3.5986 0 8.65735 0 0 9.1981 A0A8I3NSZ4 A0A8I3NSZ4_CANLF CUB domain containing protein 2 CDCP2 Canis lupus familiaris (Dog) (Canis familiaris) FHSDKHVASRGFSAGY;GVLTSPEYPDN;LVSLGHELQVIF;SSWHVMSVVFHSDKH 4 8.9 0.9885 -0.34308 0 0 0 0 0 0 0 0 0 9.1765 0 8.38344 8.27468 0 9.78813 A0A8I3NSZ8 A0A8I3NSZ8_CANLF Ataxin 7 ATXN7 Canis lupus familiaris (Dog) (Canis familiaris) ESSGNSTNCHNASSSTS;GAAAAAARQQQQQQQQQPP;GPGAASTS;GRGYYVFDSRWNRLRCA;PIDPPPVHESPHPP;PLDRLIGKKR;QQQQQQQQQPPSQPQR 7 10.1 0.93551 0.099145 0 0 0 0 0 0 0 0 0 0 0 0 0 5.63256 9.35341 A0A8I3NT03 A0A8I3NT03_CANLF POU domain protein POU2F3 Canis lupus familiaris (Dog) (Canis familiaris) keratinocyte differentiation [GO:0030216]; negative regulation by host of viral transcription [GO:0043922]; wound healing [GO:0042060] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DFNRQIKTEDLSDSLQ;SQAIGRPGLPGSSLE;VNASPCHDM 3 9.2 0.99486 -0.15542 0 0 13.0941 0 0 0 0 13.6612 0 8.59984 0 0 0 0 0 A0A8I3NT05 A0A8I3NT05_CANLF AP complex subunit sigma AP4S1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] DEYFSRVSELDVSFFKAVSQ;MAIYEFIHNFVEVL 2 24.8 0.9867 -0.23517 0 0 0 0 0 0 0 0 0 0 10.1352 0 0 0 0 A0A8I3NT09 A0A8I3NT09_CANLF Butyrophilin like 2 BTNL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDALLTCQLL;EIELICSSEGW;ILVLLLAALVGLVKRK;IVLILVLLLAALVGLVKRK;IVLILVLLLAALVGLVKRKS;KIVLILVLLLAALVGLVKRK;KIVLILVLLLAALVGLVKRKSCE;VISIPEKFQNE;VLILVLLLAALVGLVKR 9 11.3 0.98803 -0.48594 0 7.11385 5.5186 7.79695 7.62249 4.49685 9.97054 7.64068 7.6664 0 0 0 0 3.17117 0 A0A8I3NT13 A0A8I3NT13_CANLF Fem-1 homolog A FEM1A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of inflammatory response [GO:0050728]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; mitochondrion [GO:0005739] EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] LSGRSREELDELTGEVAGGGT;VGRFPSLQ 2 4.5 1.0018 -0.7495 0 0 0 0 0 0 0 10.9241 0 0 0 0 0 0 0 A0A8I3NT14 A0A8I3NT14_CANLF Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) ARHGAP15 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096] FIILDWFHA;IVNQEKQDYNTRIET;SLVQKLPP 3 7.4 1.0015 -0.69846 0 0 0 7.15157 0 13.1008 0 0 0 0 0 0 0 0 0 A0A8I3NT21 A0A8I3NT21_CANLF Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) (EC 2.3.2.24) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (E2 ubiquitin-conjugating enzyme C) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) UBE2C Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] LQQELMTLMVYEDLRYK 1 11.3 0.9832 0.046227 0 9.06205 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NT26 A0A8I3NT26_CANLF SAYSVFN motif domain containing 1 SAYSD1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] PEERKEGE;VLSLFYWMYVGTRGPEERKEGE 2 12 1.0032 -1.336 0 0 0 9.10499 0 0 0 11.8424 0 0 0 0 0 0 0 A0A8I3NT30 A0A8I3NT30_CANLF S-adenosylmethionine synthase (EC 2.5.1.6) MAT2A Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; one-carbon metabolic process [GO:0006730]; protein heterooligomerization [GO:0051291]; protein hexamerization [GO:0034214]; S-adenosylmethionine biosynthetic process [GO:0006556] cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478] AELRRNGTLPWL;AKYLDEDTIYHLQPS;SYRETSFLQ 3 8.7 1.0035 -1.071 0 0 10.385 0 0 0 0 9.41185 0 0 0 0 0 0 0 A0A8I3NT32 A0A8I3NT32_CANLF Cadherin 3 CDH3 Canis lupus familiaris (Dog) (Canis familiaris) hair cycle process [GO:0022405]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinization [GO:0031424]; negative regulation of timing of catagen [GO:0051796]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of melanin biosynthetic process [GO:0048023]; positive regulation of melanosome transport [GO:1902910]; retina homeostasis [GO:0001895] adherens junction [GO:0005912]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALLLLLLVLLLLVR;ALLLLLLVLLLLVRR;ALLLLLLVLLLLVRRK;ALLLLLLVLLLLVRRKR;AVLALLLLLLVLLLLVRRKR;CDCHGHVE;EPRWITICNQSPVPQMLNI;FLLPLLGAVLALLLLLLVLL;GAVLALLLLLLVLL;GAVLALLLLLLVLLLLVR;GAVLALLLLLLVLLLLVRR;GAVLALLLLLLVLLLLVRRK;GAVLALLLLLLVLLLLVRRKR;GRARAASGQSAPTCAHLAP;KREWVVPPISV;LALLLLLLVLLL;LALLLLLLVLLLL;LALLLLLLVLLLLVRR;LALLLLLLVLLLLVRRK;LALLLLLLVLLLLVRRKR;LGAVLALLLLLLVLLLLVRRK;LGAVLALLLLLLVLLLLVRRKR;LLGAVLALLLLLLVLLLL;LLGAVLALLLLLLVLLLLV;LLLLLLVLL;LLLLLLVLLL;LLLLLLVLLLLVRRK;LLLLLLVLLLLVRRKR;LLLLLVLLLLVRRKRK;LLLLVLLLLVRRK;LLLLVLLLLVRRKRKV;LLLLVLLLLVRRKRKVK;LLLLVLLLLVRRKRKVKE;LLLVLLLLVRRKRK;LLLVLLLLVRRKRKVK;LLLVLLLLVRRKRKVKE;LLLVRRKRKVKEPLL;LLVLLLLVRRKRKVK;LLVLLLLVRRKRKVKE;LPLLGAVLALLLLLLVLLLLVR;LVLLLLVRRKRKVKEPLLLPED;LVRRKRKVK;VLALLLLLLVLLLLVRR;VLALLLLLLVLLLLVRRK;VLLLLVRRKRK;VLLLLVRRKRKVK;VLLLLVRRKRKVKEPLLLP 47 9.2 1.0028 -2.5187 9.14157 9.56226 8.37521 6.29245 8.17991 9.4044 6.31796 13.4439 10.2899 6.26399 7.59261 5.25058 10.5768 6.9431 7.7864 A0A8I3NT36 A0A8I3NT36_CANLF Transcription factor E2-alpha (Transcription factor 3) TCF3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] DINEAFKELGRMCQL;ERMGYQLHGAEVNG;QMVLSAAHPGLSEAH;SWGAGDQNSSSFDPSRTYGDGTHFS;VGSGSSGG 5 11.8 1.0024 -1.0202 0 0 0 0 0 0 0 0 0 4.87041 0 10.573 0 0 5.79236 A0A8I3NT40 A0A8I3NT40_CANLF Uncharacterized protein CD2BP2 Canis lupus familiaris (Dog) (Canis familiaris) U5 snRNP [GO:0005682] DSDEEDDDDEGS;GGGGGKGG;GVGDEDDEDEISV;HSLDSDEEDDDDEGS;PSLDMFAE 5 12.8 1.0031 -1.5317 0 10.1378 0 0 9.53644 7.18775 0 0 0 0 0 0 0 4.25482 0 A0A8I3NT46 A0A8I3NT46_CANLF cathepsin X (EC 3.4.18.1) CTSZ Canis lupus familiaris (Dog) (Canis familiaris) epithelial tube branching involved in lung morphogenesis [GO:0060441]; negative regulation of plasminogen activation [GO:0010757]; proteolysis [GO:0006508] cell cortex [GO:0005938]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; cysteine-type endopeptidase activity [GO:0004197] GWLRPGCQQLPCHHDCGK;KFNQCGTCT;LLRLLLLG;LLSVQHVLDCAN;PASLSSWGTYPRPHEYLSPSDLP 5 17.5 1.0019 -1.4329 0 10.0556 0 9.5463 0 0 0 0 0 0 0 0 0 10.9849 0 A0A8I3NT53 A0A8I3NT53_CANLF Gap junction protein epsilon 1 GJE1 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154]; cell morphogenesis [GO:0000902]; lens development in camera-type eye [GO:0002088]; organ growth [GO:0035265] connexin complex [GO:0005922] GVLGFAVYGNEALHF 1 7.3 0.9873 -0.22981 0 0 0 0 0 0 8.89115 0 0 0 0 0 0 0 0 A0A8I3NT60 A0A8I3NT60_CANLF Uncharacterized protein ATP13A1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type transmembrane transporter activity [GO:0140358] LSQVLRELE;LVLATICLAHAL;PEAALLVLATICLA;PVETHRALASCHSLMQL;SLALEHALCLTGDGL;VGAAAAGC 6 5.5 1.0024 -1.1382 9.26186 0 0 8.60028 10.1733 0 0 12.5209 10.0692 0 0 0 0 9.94219 0 A0A8I3NT77 A0A8I3NT77_CANLF M-phase inducer phosphatase (EC 3.1.3.48) CDC25B Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; positive regulation of cell cycle G2/M phase transition [GO:1902751] protein tyrosine phosphatase activity [GO:0004725] LVKTSEKEEEQ;PETMAALLAGKFSN 2 4.7 0.99001 -0.21741 0 0 0 8.85863 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NT82 A0A8I3NT82_CANLF Uncharacterized protein RCAN3 Canis lupus familiaris (Dog) (Canis familiaris) EEEEEMVFGENEDDLEEMMD;KVKLKRKKKQKTPNRKLPRQGA;SDQEEEEEMVFGENEDDLE;SVKVKLKRKKKQKTPNRKLP;VKVKLKRKKK 5 40.9 0.98974 -0.51655 0 0 4.74578 5.47181 0 0 0 0 0 0 0 6.02976 5.00486 2.25997 0 A0A8I3NT87 A0A8I3NT87_CANLF Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) USP46 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytosol [GO:0005829]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] CETCCSKQ;IVEKIDAQ;KLKNGNMNEPAENNKPEL;QAIEEFYGL;TQKKKVGVIPPKKFISRLRKEN 5 18.9 1.0032 -2.4023 8.79941 0 0 6.84574 0 0 8.64151 0 0 7.91707 0 0 0 0 0 A0A8I3NT88 A0A8I3NT88_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SVIDMPLVTKSCYSGCPDISTLG 1 24 0.99264 -0.28203 0 0 0 0 0 0 0 8.76278 0 0 0 0 0 0 0 A0A8I3NT89 A0A8I3NT89_CANLF DNA-directed RNA polymerase subunit (EC 2.7.7.6) POLR1A Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] RNA polymerase I complex [GO:0005736] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] EEVGSGPEDSPPATPL;GKAWVQESPRPVPG;LGTHQILKMWGEL;MKDMVLIRKL;QEEEVDYESEEEEVEEENEDEDMQ;TPMMSVPV;TSRSGYLQ 7 5.7 1.0014 -2.6799 0 0 0 11.9485 12.7798 0 0 0 7.65499 12.6692 7.64976 0 0 0 6.21325 A0A8I3NT91 A0A8I3NT91_CANLF Transmembrane protein 33 TMEM33 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum tubular network organization [GO:0071786]; membrane organization [GO:0061024] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] TDPTEENCNPKQ;YCSALFVLPLLGLHEAASFYQR 2 14.3 0.99037 -0.21361 0 7.31705 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NT93 A0A8I3NT93_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHNHYTQKSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;EALHNHYTQKSLSHSPG;EDGSYFLYSKL;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPEG;FIFPPKPKDTLL;FLYSKLSVDKSR;FPPKPKDTLL;FPSVLQSSGL;GGPSVFIFPPKPKDTLL;GPSVFIFPPKPKD;GPSVFIFPPKPKDTLL;GRVPRPPD;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GTYRVVSVLPIGHQD;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HNHYTQKSLSHSPG;HTFPSVLQSSGL;HYTQKSLSHSPG;IFPPKPKD;IFPPKPKDTLL;IFPPKPKDTLLIAR;KLSVDKSR;LHNHYTQKSLSHSPG;LPSPIERTISKARG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LVESGGDLVK;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTQKSLSHSPG;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;PEDPEVQIS;PPKPKDTLL;PSVFIFPPKPKDTLL;QKSLSHSPG;QSSGLYSLSSM;RTTPPQLDED;RTTPPQLDEDGSYFL;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TFPSVLQSSGL;TPPQLDEDGSYFL;TQKSLSHSPG;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TTPPQLDEDGSYFL;TYRVVSVL;TYRVVSVLPIG;TYRVVSVLPIGHQD;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VMHEALHNHYTQKSLSHSPG;VRQAPGKGLQ;VTVPSSRWPSET;VTVSSASTTA;VTVSSASTTAPSVF;VTVSSASTTAPSVFPL;VTVSWNSGSLTSGVHTFPSVL;VVSVLPIGHQD;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTQKSLSHSPG;YVLPPSRE;YVLPPSREE;YVLPPSREELSK 114 45.9 0 21.109 11.1896 12.1777 10.329 9.3046 8.89339 8.30643 0 9.73635 9.07642 10.5638 11.4103 11.6037 8.54959 11.4781 11.1813 A0A8I3NTA2 A0A8I3NTA2_CANLF Potassium voltage-gated channel subfamily V member 1 (Voltage-gated potassium channel subunit Kv8.1) KCNV1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] intercellular bridge [GO:0045171]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] ETLDFKKDTEDQESQ;RIVQVLRLLRALRML;SSGGDDFW;VCISWFTGEFVLRFL;VGRIVQVLRLLRAL;VGRIVQVLRLLRALR;VLRLLRALRMLKLGRH 7 12 1.0028 -0.77882 0 0 0 0 3.98295 9.24918 9.76995 12.8931 7.67462 0 0 0 0 7.4271 3.44162 A0A8I3NTB0 A0A8I3NTB0_CANLF Metallophosphoesterase domain containing 1 MPPED1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] APAPLPAHPARGRA;EGYGVMADGTTT;PGYTRFVCVSDTHSRTDPIQ 3 7.5 0.99555 -0.56828 6.3991 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTB8 A0A8I3NTB8_CANLF WD repeat domain 86 WDR86 Canis lupus familiaris (Dog) (Canis familiaris) EQLRVFREHQGSV;LTFPGSPT;PPHPPPAE;RAPPPPRGAAPASSAT 4 5.7 0.98947 -0.2632 0 11.7502 0 0 0 0 0 0 0 0 11.4249 0 0 0 0 A0A8I3NTD8 A0A8I3NTD8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YHWANIYRLIHRKQDSD 1 14.5 0.98417 0.046227 0 0 0 0 0 7.1822 0 0 0 0 0 0 0 0 0 A0A8I3NTD9 A0A8I3NTD9_CANLF SRY-box transcription factor 5 SOX5 Canis lupus familiaris (Dog) (Canis familiaris) cell fate commitment [GO:0045165]; positive regulation of chondrocyte differentiation [GO:0032332] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHDEQKKLAASQIE;DINGEIYDEFDEEEDDPDVDY;EGKFSHAMMDFNMSGDSDGSA;EIYDEFDEEEDDPDVDYGSDSENHI;GEIYDEFDEEEDDPDVDYG;GSGNFGEIKGTPESLA;LPAFHLPLHVSFPNKPHS;QQQQLLQQQHKI 8 17.1 0.9875 -0.34908 12.1599 0 9.13922 6.89833 0 0 0 0 0 0 0 6.10146 0 0 0 A0A8I3NTE5 A0A8I3NTE5_CANLF Stabilizer of axonemal microtubules 1 SAXO1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821] axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126] microtubule binding [GO:0008017] AEPPGYIF;HFEGSTTTKDD;TTKDDYKQWPGM;YPCGDKMECLPTYKADYLPWNQ 4 10.1 1.0045 -1.0537 0 0 5.587 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTE6 A0A8I3NTE6_CANLF Exocyst complex component 3 like 4 EXOC3L4 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] exocyst [GO:0000145] ATTDQSQAAAV;EDAVRTSAQERVRAAA 2 3.7 0.94265 0.087971 0 0 0 0 0 0 0 5.62971 9.81375 0 0 0 0 0 0 A0A8I3NTF4 A0A8I3NTF4_CANLF WAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] TRPHFINPKDALSD 1 16.9 0.94096 0.061086 6.27422 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTF6 A0A8I3NTF6_CANLF Cytochrome P450 4A37 CYP4A37 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" EGELEKIRNKR;GVGRELSKPITFPDGRSLPRGMEEG;RFAPDASRHSH 3 9.3 0.97419 0.035538 0 0 0 0 0 9.03194 0 0 0 0 0 0 0 0 0 A0A8I3NTF8 A0A8I3NTF8_CANLF Acid sphingomyelinase-like phosphodiesterase SMPDL3B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] extracellular space [GO:0005615]; plasma membrane [GO:0005886] sphingomyelin phosphodiesterase activity [GO:0004767]; zinc ion binding [GO:0008270] VGRLTRLIREVFPD;VSEDPLQVCPS 2 5.5 0.92903 0.09626 0 0 6.93404 0 0 0 0 0 0 0 7.3837 7.89736 0 0 0 A0A8I3NTG5 A0A8I3NTG5_CANLF Galactose-3-O-sulfotransferase 3 GAL3ST3 Canis lupus familiaris (Dog) (Canis familiaris) glycolipid biosynthetic process [GO:0009247] membrane [GO:0016020] galactosylceramide sulfotransferase activity [GO:0001733] PNGGAGPA;RAWNALDAGL;RFAERHNLTVALPHPSCE;SPRDDAAYLA 4 10.7 1.0041 -1.0908 0 9.49695 8.68071 8.90262 0 0 0 0 10.0988 9.15939 0 0 0 0 8.16621 A0A8I3NTH0 A0A8I3NTH0_CANLF Uncharacterized protein LY6D Canis lupus familiaris (Dog) (Canis familiaris) lymphocyte differentiation [GO:0030098] cell surface [GO:0009986] TPAWGGGQ 1 3.6 1.0046 -1.1044 0 0 0 0 0 0 0 3.16821 0 0 0 9.41098 0 0 0 A0A8I3NTH7 A0A8I3NTH7_CANLF Hepatocyte nuclear factor 4 alpha HNF4A Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] TVGLAGLLFWGGQTVNALMP 1 7.9 0.96415 0.048688 0 0 8.59302 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTH8 A0A8I3NTH8_CANLF Olfactory receptor OR2T4C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IDQIMGISNISAP 1 4.1 0.98887 -0.21803 10.374 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTH9 A0A8I3NTH9_CANLF Coiled-coil domain containing 198 CCDC198 Canis lupus familiaris (Dog) (Canis familiaris) EDFGEYQAMNDY;EDFGEYQAMNDYCP;ETSIIKRHPPRRLQK 3 9.8 0.9889 -0.52312 0 0 0 0 0 0 0 0 5.8107 0 0 0 9.12099 0 0 A0A8I3NTI8 A0A8I3NTI8_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" MAN1C1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" EAGFSGIQDVYSS;ESYMYLWRQTHNPIYREWGWEVVMA;GATIIDSLDTLYLMELQE;LSGNQVFAEKVRNIRKVLRK 4 12 0.99489 -0.12674 0 0 0 0 0 0 5.59195 0 9.98826 0 0 11.4357 0 6.99073 0 A0A8I3NTJ3 A0A8I3NTJ3_CANLF Origin recognition complex subunit 5 ORC5 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634]; origin recognition complex [GO:0000808] NHLCSSEDGCSTQVTCETFNDFV;VECFTSRLLL 2 10.2 0.99525 -0.56484 9.49362 0 0 0 0 0 0 7.50772 0 0 0 0 0 0 9.97284 A0A8I3NTK1 A0A8I3NTK1_CANLF USH1 protein network component harmonin USH1C Canis lupus familiaris (Dog) (Canis familiaris) brush border assembly [GO:1904970]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] apical part of cell [GO:0045177]; brush border [GO:0005903]; cytosol [GO:0005829]; microvillus [GO:0005902] spectrin binding [GO:0030507] EEEEKFKKQW;EEVINLIRTKKTVSIKVRHIGLIP;GKPTNSPVPERSFP;INLIRTKKTVSIKVRHIGLIPV;SLVGSRGL;VLRMYHQTMDV 6 7.6 1.0013 -0.93749 0 4.8501 0 9.07954 0 0 0 0 8.28313 0 0 0 0 0 0 A0A8I3NTK6 A0A8I3NTK6_CANLF Dynein light chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874] TWHCIVGRNFGSYVIHETKHFIYFY 1 25.8 0.97846 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.37249 A0A8I3NTK7 A0A8I3NTK7_CANLF Rho GTPase activating protein 15 ARHGAP15 Canis lupus familiaris (Dog) (Canis familiaris) SSRKIEFYKESKQQALSNVSFYLIW 1 18.2 0.97853 0.035538 0 0 7.90503 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTL1 A0A8I3NTL1_CANLF "Proton-coupled zinc antiporter SLC30A9, mitochondrial (Solute carrier family 30 member 9) (Zinc transporter 9)" SLC30A9 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion transport [GO:0006829] endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] antiporter activity [GO:0015297]; monoatomic cation transmembrane transporter activity [GO:0008324] KAPLIKQEPLQVRVKAVLKKR;LPLECKCGIYFSSVFHPVK;LRKIRRRSPHE;QMLQEIQEVKTPEELETFMLKHGE 4 13.4 0.95118 0.04967 0 0 0 0 0 0 0 0 8.47816 0 0 0 0 0 0 A0A8I3NTM1 A0A8I3NTM1_CANLF Grainyhead like transcription factor 3 GRHL3 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; cochlea morphogenesis [GO:0090103]; ectoderm development [GO:0007398]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; eyelid development in camera-type eye [GO:0061029]; pattern specification process [GO:0007389]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of gene expression [GO:0010628]; regulation of actin cytoskeleton organization [GO:0032956]; transcription by RNA polymerase II [GO:0006366]; wound healing [GO:0042060] nucleoplasm [GO:0005654] "chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FLYDYYMGPKEKRI;MDYEMDLAPLESP;SVDSYLLPTSDMYDNSSLN 3 7.7 0.98686 -0.35868 0 0 0 0 0 11.2592 0 0 0 0 0 10.1741 0 6.51213 0 A0A8I3NTM2 A0A8I3NTM2_CANLF Ring finger protein 24 RNF24 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] zinc ion binding [GO:0008270] DFKPRDELGICPCKHAF 1 11.5 0.98137 0.046227 0 0 0 0 0 0 0 0 8.16279 0 0 0 0 0 0 A0A8I3NTN4 A0A8I3NTN4_CANLF Ig-like domain-containing protein LOC119881742 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046] SGDSGGCH 1 2.6 1.0032 -1.1044 0 0 0 0 0 0 0 0 6.22556 0 0 0 0 0 0 A0A8I3NTN9 A0A8I3NTN9_CANLF Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) FARSA Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] cytosol [GO:0005829]; phenylalanine-tRNA ligase complex [GO:0009328] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049] FRPEMLLPMGL;VGSWRDRPFKPY 2 4.8 0.98871 -0.20416 0 0 9.65439 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTP7 A0A8I3NTP7_CANLF Bystin like BYSL Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; stem cell proliferation [GO:0072089]; trophectodermal cell differentiation [GO:0001829]" apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AEDERAIEMFM;ITKCSIPVLHSSAAMLKIAEMEY 2 7.8 0.98532 -0.24515 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.28429 A0A8I3NTR5 A0A8I3NTR5_CANLF R3H-associated N-terminal domain-containing protein R3HDM4 Canis lupus familiaris (Dog) (Canis familiaris) GSGGGACC;LENTQYLLTL;VGSPPGGQ 3 5.3 1.0032 -1.6254 0 0 0 0 0 0 10.0847 0 0 0 0 11.3257 5.90828 6.37172 5.49179 A0A8I3NTS5 A0A8I3NTS5_CANLF TANK binding kinase 1 TBK1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AATGSLPFRPFEGP;EDDEQFVSLYGT;LEEPSNAYGLPES;LVEMTLGFGSLTMDGGLRNVDCL 4 8.8 0.98678 -0.38381 0 0 0 0 0 9.3308 8.13253 0 10.0044 0 0 0 0 0 0 A0A8I3NTS8 A0A8I3NTS8_CANLF Gap junction protein GJA4 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel development [GO:0001568]; cell communication [GO:0007154] connexin complex [GO:0005922] EQNWANLTTEER;SEQNWANLTTEERLASSRAPLFLDP;TVVGKIWLTVLFIFRILILGL;VGKIWLTVLFIFRILIL;VGLISLVLNLLELAHLL 5 18.9 0.98695 -0.39704 0 0 0 0 5.11036 7.26172 0 11.0173 0 0 0 8.87261 0 0 0 A0A8I3NTT5 A0A8I3NTT5_CANLF Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) SLC30A8 Canis lupus familiaris (Dog) (Canis familiaris) insulin processing [GO:0030070]; insulin secretion [GO:0030073]; intracellular zinc ion homeostasis [GO:0006882]; response to glucose [GO:0009749]; zinc ion import into organelle [GO:0062111] plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658] protein homodimerization activity [GO:0042803]; zinc:proton antiporter activity [GO:0140826] LVYLACERLLY 1 3 0.99388 -0.17256 0 0 0 0 0 0 0 0 0 0 0 0 11.6388 0 0 A0A8I3NTV1 A0A8I3NTV1_CANLF Inositol polyphosphate-5-phosphatase F INPP5F Canis lupus familiaris (Dog) (Canis familiaris) ARRERRWRQRLLIDATHR;KVNQYQRLSLEDLEKIEI 2 23.7 0.97166 0.048313 0 7.71019 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTV6 A0A8I3NTV6_CANLF Jun dimerization protein 2 JDP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ERTEFLQRESERLE 1 8.6 0.98417 -0.24196 0 0 0 0 0 0 0 10.1237 0 0 0 0 0 0 0 A0A8I3NTV7 A0A8I3NTV7_CANLF Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D) CFD Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] HPDSRRDTIE;VLLGAHSLSQPEPSKRW 2 10.5 0.99003 -0.21136 7.10087 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NTV9 A0A8I3NTV9_CANLF Sulfotransferase (EC 2.8.2.-) LOC102151402 Canis lupus familiaris (Dog) (Canis familiaris) sulfotransferase activity [GO:0008146] HVLSWEEHKNDKNILIIFYEEMKKD 1 8.8 0.98987 -0.2984 0 0 0 0 0 0 9.71918 0 0 0 0 0 0 0 0 A0A8I3NTX0 A0A8I3NTX0_CANLF Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (Dehydrogenase/reductase SDR family member 8) HSD17B11 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811] AVGFHKALTE;LLKLFIPKKRKSVTG;LPLLIIFTLESLLKLFIPKKRKS;VNNAGVVY 4 14.7 1.0017 -1.257 0 0 0 6.07692 7.06942 0 0 0 0 0 0 0 0 0 0 A0A8I3NTX2 A0A8I3NTX2_CANLF Mitochondrial antiviral signaling protein MAVS Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to bacterium [GO:0042742]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of IP-10 production [GO:0071660]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein localization to mitochondrion [GO:0070585]; regulation of peroxisome organization [GO:1900063] mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778] CARD domain binding [GO:0050700]; identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RIG-I binding [GO:0039552]; signaling adaptor activity [GO:0035591] LPGLDRSSAGWGS 1 2.5 0.94126 0.059858 0 0 0 0 0 0 0 0 0 0 0 8.0935 0 0 0 A0A8I3NTX7 A0A8I3NTX7_CANLF Myocyte enhancer factor 2C MEF2C Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GVTHRPPSAGN;KKIQITRIMDERNRQ;NEFHSPIGLTRPSPDE 3 9.5 0.99587 -0.095031 0 0 0 0 8.56472 0 0 0 0 0 0 0 0 9.29648 9.46097 A0A8I3NTY0 A0A8I3NTY0_CANLF Golgi associated kinase 1B GASK1B Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; membrane [GO:0016020] AAHAPPGA;EWSKLALFDFLL 2 4.1 0.98999 -0.26592 0 0 0 0 0 0 0 9.8505 10.1459 0 0 0 0 0 0 A0A8I3NTY8 A0A8I3NTY8_CANLF Glucosamine-6-phosphate isomerase (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase) GNPDA1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine metabolic process [GO:0006044]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737] glucosamine-6-phosphate deaminase activity [GO:0004342]; isomerase activity [GO:0016853] RDHPESYHSFMWNHFFKHIDIRPEN 1 8.7 0.97384 0.035538 0 0 0 0 0 0 0 0 0 5.28366 0 0 0 0 0 A0A8I3NTZ4 A0A8I3NTZ4_CANLF threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) TARS2 Canis lupus familiaris (Dog) (Canis familiaris) threonyl-tRNA aminoacylation [GO:0006435] cytoplasm [GO:0005737] ATP binding [GO:0005524]; threonine-tRNA ligase activity [GO:0004829] SPADEFNSGRY;VERMLGVLAESYG 2 5.4 0.98807 -0.22405 0 0 0 0 0 0 10.6134 0 0 3.15961 0 0 0 0 0 A0A8I3NU07 A0A8I3NU07_CANLF Sperm microtubule associated protein 2 SPMAP2 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] RNLQFCVWWP;RNLQFCVWWPSV;VSRAAQLAIPSPRI 3 6.8 0.99722 -0.59578 0 0 0 0 0 0 0 0 0 0 0 0 0 8.37513 0 A0A8I3NU08 A0A8I3NU08_CANLF Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 RAPH1 Canis lupus familiaris (Dog) (Canis familiaris) axon extension [GO:0048675]; signal transduction [GO:0007165] cell leading edge [GO:0031252]; cytosol [GO:0005829]; nuclear body [GO:0016604]; plasma membrane [GO:0005886] AAELLCKTTSLSSI;KDDGKKSW;LDWSLVETI;QKKSQYIK;QMERIFEDHENLVENLLNWT 5 6.4 0.99619 -0.091109 0 0 0 0 0 0 0 0 0 0 9.98499 0 0 0 0 A0A8I3NU10 A0A8I3NU10_CANLF Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) DR1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of tubulin deacetylation [GO:0090043]; RNA polymerase II preinitiation complex assembly [GO:0051123] ATAC complex [GO:0140672]; negative cofactor 2 complex [GO:0017054]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] EEELLRQQQEL 1 6.2 0.9855 -0.24606 0 0 0 0 0 12.1053 0 0 0 0 0 0 0 0 0 A0A8I3NU11 A0A8I3NU11_CANLF Syndecan 4 SDC4 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477] cell surface [GO:0009986]; membrane [GO:0016020] VLQDHMVQPARWQKQTP 1 10.1 0.97688 0.046227 0 0 0 10.6917 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NU13 A0A8I3NU13_CANLF Olfactory receptor OR6K3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AEGRQKAFSTCGG;DVIHAVAIIITILIIALSYIRI;SLMYLRFNAT;VPVLRLACT 4 16.9 1.003 -1.3841 0 0 0 0 0 0 0 0 10.2955 0 0 0 0 9.94813 0 A0A8I3NU34 A0A8I3NU34_CANLF Solute carrier family 37 member 2 SLC37A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glucose 6-phosphate:phosphate antiporter activity [GO:0061513] SEGRREPTRG;TCYHMSRK 2 2.7 1.0028 -1.1222 0 0 0 0 0 0 7.92961 7.9219 0 0 0 0 0 0 0 A0A8I3NU35 A0A8I3NU35_CANLF WAS/WASL interacting protein family member 1 WIPF1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament-based movement [GO:0030048]; response to other organism [GO:0051707] actin filament [GO:0005884] actin binding [GO:0003779]; SH3 domain binding [GO:0017124] GGGGGGGG;GGGGPPGL;PEPQRNRMPP;PPQGDLCLLFSTGV;SKGKKLKKT 5 9.9 1.0033 -2.443 10.2569 0 0 8.53185 0 0 9.57877 0 0 0 0 0 0 0 3.67107 A0A8I3NU47 A0A8I3NU47_CANLF Cortactin CTTN Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin filament polymerization [GO:0030833] actin filament [GO:0005884]; cortical actin cytoskeleton [GO:0030864]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; site of polarized growth [GO:0030427] actin filament binding [GO:0051015] DYKAGFGG;IEMIDDGWWRGLCKGRYG;PVYSMEAA 3 4.8 1.003 -2.1605 8.93531 0 0 0 0 0 0 8.80093 7.95338 0 0 0 0 0 8.11369 A0A8I3NU51 A0A8I3NU51_CANLF Ankyrin repeat domain 40 ANKRD40 Canis lupus familiaris (Dog) (Canis familiaris) DRQELTYQELLRVSCCELGVNP;EAPPAGAF;FPRDHTSLAL 3 10.7 1.0014 -1.3153 0 0 13.6327 0 0 0 0 0 0 0 0 0 0 11.1532 0 A0A8I3NU57 A0A8I3NU57_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8B2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AFRFLKLSLK;AIGDGANDVSMIKTAH;DKKFLFWDS;EQRSMEYPKLYEPGQLNLLF;IDRLMNTLVLWIFGFLVC;IFGFLVCMGVILAIGNAIWE;PNQFRFVGNAQNTLA;RLLLVHGR;TAINHFFIW;VLTGDKQETAV 10 11.1 1.0035 -2.4463 8.58658 10.7474 0 0 0 8.40263 0 6.03012 0 0 4.91853 0 10.0713 10.2341 11.7806 A0A8I3NU72 A0A8I3NU72_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; tissue development [GO:0009888] IIILTVIIIVVVL 1 5.9 0.95248 0.059561 5.71295 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NU82 A0A8I3NU82_CANLF Uncharacterized protein LOC485601 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] EKSRPGAH;LITSHLPK;QACRGERRDSGVETDDEPMESDD;SDDVSEKRRLPTFSDYF;VLVKVLRQLRRADLLRL 5 16.5 1.003 -0.88449 0 0 0 0 0 7.47752 8.00276 0 0 0 0 0 0 0 10.3424 A0A8I3NU96 A0A8I3NU96_CANLF Chromosome 1 open reading frame 216 C15H1orf216 Canis lupus familiaris (Dog) (Canis familiaris) LDNRKELIRCLQQ 1 5.7 0.93767 0.059742 0 0 5.96528 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NU97 A0A8I3NU97_CANLF DC-STAMP domain containing 1 DCST1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CWDDMRRRCPACTPREE;GEFSATIDLKEE;LDRRCPLLRRWLRQ;PSRYHLSTQKMY;TSWEHVSAE 5 9.4 1.0011 -0.94454 0 0 0 8.14568 0 0 0 0 8.91088 0 0 0 0 4.63639 8.91283 A0A8I3NUA8 A0A8I3NUA8_CANLF Kinesin family member 15 KIF15 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] CKYNSALADKDESKVL;EVKNAEILRIKEQLCEMEN;EYPQSPKTPPHF;KACLQDSYDNLQEVMKFE;TEKLKAQL;VEIRDLKEALRLRIL 6 9.9 1.0017 -0.99615 0 0 12.1478 0 0 0 0 0 0 7.59775 0 0 9.02777 0 0 A0A8I3NUB2 A0A8I3NUB2_CANLF Potassium inwardly rectifying channel subfamily J member 8 KCNJ8 Canis lupus familiaris (Dog) (Canis familiaris) "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; atrioventricular node cell differentiation [GO:0060922]; calcium ion transmembrane transport [GO:0070588]; CAMKK-AMPK signaling cascade [GO:0061762]; coronary vasculature development [GO:0060976]; defense response to virus [GO:0051607]; determination of adult lifespan [GO:0008340]; establishment of cell polarity [GO:0030010]; fat cell differentiation [GO:0045444]; fatty acid transport [GO:0015908]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; glutamate secretion, neurotransmission [GO:0061535]; heart morphogenesis [GO:0003007]; microglial cell activation [GO:0001774]; neuromuscular process [GO:0050905]; NLRP3 inflammasome complex assembly [GO:0044546]; p38MAPK cascade [GO:0038066]; potassium ion import across plasma membrane [GO:1990573]; protein secretion [GO:0009306]; reactive gliosis [GO:0150103]; regulation of blood pressure [GO:0008217]; regulation of heart rate [GO:0002027]; regulation of monoatomic ion transmembrane transport [GO:0034765]; response to ATP [GO:0033198]; response to cytokine [GO:0034097]; response to endoplasmic reticulum stress [GO:0034976]; response to exogenous dsRNA [GO:0043330]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to resveratrol [GO:1904638]; response to xenobiotic stimulus [GO:0009410]; synaptic assembly at neuromuscular junction [GO:0051124]; transmission of nerve impulse [GO:0019226]; vasodilation [GO:0042311]; ventricular cardiac muscle tissue development [GO:0003229]" monoatomic ion channel complex [GO:0034702]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; presynapse [GO:0098793] ATP-activated inward rectifier potassium channel activity [GO:0015272]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1902282] GVYSVDYSKFGNTVKVAA;NIVGLIINAVMLG 2 7.3 0.98997 -0.30537 0 0 0 10.2346 0 0 0 0 10.0739 0 0 0 0 0 0 A0A8I3NUB3 A0A8I3NUB3_CANLF CAP-Gly domain containing linker protein family member 4 CLIP4 Canis lupus familiaris (Dog) (Canis familiaris) MADAAATAKEIKQML;PGYWYGIELEKPHGKNDGSV;SASSHKEMNRRNAFA;SSNEMGTVSTSTSSG 4 9.6 1.0027 -0.77512 0 0 0 0 0 0 0 0 0 9.98826 0 0 0 6.97143 0 A0A8I3NUB5 A0A8I3NUB5_CANLF cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) MOCS1 Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829] "4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]" ASCRAWGPTGV;EVQRPEVQLGRSSD;GEQQREWTTTPR;RVSFSNRMS;VGIRASCRAWGPT 5 7.4 1.002 -0.90868 0 0 0 0 0 7.77933 9.90034 10.136 0 0 0 0 0 0 0 A0A8I3NUC3 A0A8I3NUC3_CANLF Olfactory receptor OR9K2D Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPDRFPELS;IVILVSYMYI;IVSFFLCS;LYSVQMSTRLCIQ;PELYILLFLLFLLVYAMIL 5 18.4 1.0025 -1.3736 0 0 0 0 0 0 0 10.4849 0 9.94844 0 0 10.8921 9.0621 0 A0A8I3NUC9 A0A8I3NUC9_CANLF VPS39 subunit of HOPS complex VPS39 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] DFSVPDVP;DVYLSLLRMYL;STSPLMEGTPTI 3 3.8 1.0037 -1.6044 0 0 0 0 0 6.35987 0 0 0 0 0 0 0 9.88602 0 A0A8I3NUD4 A0A8I3NUD4_CANLF Uncharacterized protein ZNF184 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HFMEHQKIHTGE;QPSDEAIVEK;RDDPCSSNFLES 3 4.5 1.002 -1.2101 0 0 0 0 0 0 0 0 10.1491 0 9.16812 0 0 0 0 A0A8I3NUD9 A0A8I3NUD9_CANLF E3 ubiquitin-protein ligase KCMF1 KCMF1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EAMDPIAELLSQ;GGGGGGGG;GGRGGGGG;HSRPAPPPRRRRRRRRRRRRRRR;PRRRRRRRRRRRRRRRRGAL;RRRRRRRRRRRRRRRGAL;RRRRRRRRRRRRRRRRGALPCPPRP;TTNTANTESSQQTI 8 9.2 0.67667 0.27978 0 8.10135 6.57169 0 0 0 0 0 0 0 0 0 8.16742 16.6993 0 A0A8I3NUE2 A0A8I3NUE2_CANLF TSC complex subunit 1 TSC1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]; regulation of cell cycle [GO:0051726] TSC1-TSC2 complex [GO:0033596] ATSPYVDTQNSCGS;DTEPLVPRGGF;FKRQQHALRNRRLLRKVIK;HRQHHLPNDRGLEE;HVLQQNQRLDT;SPPPAPLCHSDDYV 6 7.4 0.99311 -0.5561 8.77007 0 0 0 0 9.90103 0 10.5911 12.6503 0 5.9718 0 0 10.9522 13.1442 A0A8I3NUF6 A0A8I3NUF6_CANLF Matrilin 4 MATN4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AMASPPLDEHV;ASPPLDEH;LDEHVFLVES;LENLRGSICPEEGI;LQQDQRSCRAIDHC 5 6.4 1.0029 -0.97875 7.99073 8.17393 0 0 9.19665 0 8.56921 0 0 0 0 0 8.54288 0 15.7281 A0A8I3NUH4 A0A8I3NUH4_CANLF Olfactory receptor OR9K7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MSFCASRVIDHFYCDS;VLKIRSSEGRKKAFS;VSFVYLTP 3 12.5 1.0013 -0.70642 0 0 0 0 0 0 0 0 12.4007 0 0 0 0 0 7.76182 A0A8I3NUK4 A0A8I3NUK4_CANLF Family with sequence similarity 98 member A FAM98A Canis lupus familiaris (Dog) (Canis familiaris) tRNA-splicing ligase complex [GO:0072669] DILESLEDLGYKGP;VRRKLLIKRLDVTVQ 2 9.3 0.98776 -0.40222 0 0 9.92072 9.41416 0 0 0 0 0 0 9.875 0 9.82621 0 0 A0A8I3NUL7 A0A8I3NUL7_CANLF Probable RNA polymerase II nuclear localization protein SLC7A6OS SLC7A6OS Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031] cytoplasm [GO:0005737]; nucleus [GO:0005634] DIYEDDDDENSENNWRNEYPEEEN;DQQPEDIYEDDD;DQQPEDIYEDDDDENSE;EDDDDENSEN;EFGYDSPHDLDSD;PNTPRTLPSAGT;QPYSQEWDLVN;RIRRDLRASA 8 19.3 1.0037 -1.6046 0 7.03485 8.5049 0 11.6094 0 0 0 0 5.21517 0 3.98258 0 0 10.9173 A0A8I3NUL8 A0A8I3NUL8_CANLF Galectin 9 LGALS9 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] LSTWHLSQRPSTQ 1 4.2 0.94027 0.059703 0 0 0 0 0 0 0 0 0 8.63659 0 0 0 0 0 A0A8I3NUM8 A0A8I3NUM8_CANLF R3H domain containing 2 R3HDM2 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] GSEQYQMPQSPSPCSPP;PGFQQSHYFVAL;PGFQQSHYFVALYRFKA;SIGSSKGG;SSKGGSAG 5 4.2 1.0022 -1.8726 8.80771 9.78328 0 0 8.27268 0 15.2372 0 0 4.25134 0 0 14.5294 0 0 A0A8I3NUN5 A0A8I3NUN5_CANLF Integrin subunit beta 1 binding protein 2 ITGB1BP2 Canis lupus familiaris (Dog) (Canis familiaris) Z disc [GO:0030018] calcium ion binding [GO:0005509]; zinc ion binding [GO:0008270] EMDEEESEDSDDDLSWTEE;ETLHRERPKSE 2 8.6 0.98803 -0.22585 0 0 0 0 0 0 0 0 0 0 8.66754 0 0 0 10.4094 A0A8I3NUN6 A0A8I3NUN6_CANLF SH2 domain containing adaptor protein B SHB Canis lupus familiaris (Dog) (Canis familiaris) B cell proliferation [GO:0042100]; blood vessel morphogenesis [GO:0048514]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of oocyte maturation [GO:1900194]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of T-helper cell differentiation [GO:0045624]; T cell receptor signaling pathway [GO:0050852] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] phosphotyrosine residue binding [GO:0001784]; signaling receptor complex adaptor activity [GO:0030159] AAGCCCAS;ASGAAGCC;DLKSKAGKGESAGYMEPYEAQRIM;GCCCASSGA;LAAQFNGNEKRQ;SDPFDAKN 6 11.4 0.99932 -3.1022 13.5626 6.0002 12.8933 6.44738 6.06839 0 12.8266 10.1908 0 9.66809 0 6.23471 0 0 7.61375 A0A8I3NUN8 A0A8I3NUN8_CANLF Negative elongation factor complex member C/D NELFCD Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription elongation by RNA polymerase II [GO:0034244] NELF complex [GO:0032021] RNA binding [GO:0003723] AMLSKGALNPADITV;GVLKWVDWTVSEPRYFQLQTDHTPV;RDLFYKLAEAHPDCLMLN 3 10.2 0.98739 -0.46787 0 0 0 0 9.42419 0 0 0 0 0 0 0 10.5469 0 0 A0A8I3NUP2 A0A8I3NUP2_CANLF "ATP synthase subunit d, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial proton-transporting ATP synthase, stator stalk [GO:0000274]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" LKSWNEMLIS 1 6.8 0.99985 -0.61146 0 0 10.403 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NUR1 A0A8I3NUR1_CANLF U5 small nuclear ribonucleoprotein TSSC4 TSSC4 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal tri-snRNP complex assembly [GO:0000244] cytoplasm [GO:0005737]; U5 snRNP [GO:0005682] molecular sequestering activity [GO:0140313]; protein-containing complex binding [GO:0044877] LPGGTEMEALPPGV;VLSGEAQGDSDPD 2 8.1 0.98474 -0.24145 0 0 0 7.61029 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NUR4 A0A8I3NUR4_CANLF Uncharacterized protein SFTPD Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020] DSGPSGPPG;QGEAGPKG 2 4.5 1.0028 -1.9086 0 6.37927 0 0 0 7.98874 0 0 0 0 0 0 0 0 8.69853 A0A8I3NUR5 A0A8I3NUR5_CANLF Interleukin 22 receptor subunit alpha 1 IL22RA1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; negative regulation of inflammatory response [GO:0050728] membrane [GO:0016020] interleukin-20 binding [GO:0042015]; interleukin-22 receptor activity [GO:0042018] VTSLDREAP 1 1.6 1.0043 -0.80421 0 0 0 0 0 0 0 0 0 0 0 7.27743 0 0 0 A0A8I3NUR6 A0A8I3NUR6_CANLF Zinc finger protein 311 ZNF311 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CLNRMQRLLYTDVMLENYRNMLAVG 1 3.7 0.97946 0.035538 0 0 0 0 0 8.7649 0 0 0 0 0 0 0 0 0 A0A8I3NUS2 A0A8I3NUS2_CANLF Coiled-coil domain-containing protein 72 Canis lupus familiaris (Dog) (Canis familiaris) LTKKKKRK 1 7.8 1.0031 -1.1044 5.43052 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NUS8 A0A8I3NUS8_CANLF Secretogranin-2 (Secretogranin II) SCG2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; secretory granule [GO:0030141] LDEDLLMKVLEYLNQEKAE;SEKNFPMDMSDDYET 2 5.9 0.92009 0.11513 0 0 0 0 0 8.82267 0 0 8.5585 0 0 0 0 0 10.2123 A0A8I3NUT7 A0A8I3NUT7_CANLF BICD cargo adaptor 1 BICD1 Canis lupus familiaris (Dog) (Canis familiaris) minus-end-directed organelle transport along microtubule [GO:0072385]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of microtubule cytoskeleton organization [GO:0070507]; viral process [GO:0016032] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802] cytoskeletal anchor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein intermediate chain binding [GO:0045505]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267] EVLQTVDHYKTEIE;FREARLLQDYTELEE;KQQYDELEAEY;LHRQGPQTPTIR;MFATRCDEYVTQL;QSRPRTSGATYL 6 7.9 0.99285 -0.27148 0 0 0 9.54462 0 0 0 9.25694 0 0 0 0 0 0 9.37604 A0A8I3NUU1 A0A8I3NUU1_CANLF SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) SHC1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cellular response to growth factor stimulus [GO:0071363]; defense response to bacterium [GO:0042742]; epidermal growth factor receptor signaling pathway [GO:0007173]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of cell population proliferation [GO:0042127] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ephrin receptor binding [GO:0046875]; epidermal growth factor binding [GO:0048408]; insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; neurotrophin TRKA receptor binding [GO:0005168]; phosphotyrosine residue binding [GO:0001784]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] KYNPLRNESLSSLEE;NKLSGGGG 2 4 1.005 -1.0505 0 0 0 0 8.51306 0 0 0 0 0 0 9.35823 0 0 0 A0A8I3NUU3 A0A8I3NUU3_CANLF Secernin-2 SCRN2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] APDSPCSCD;EAVWTKEP;ELLRQEQGGLTAEV;TPDPSRSVFKPFIFGAG;VLSPTFGAQD 5 13.4 1.0006 -2.7994 0 0 0 4.09719 0 9.46099 8.87255 0 0 0 0 7.86183 11.2395 9.94009 8.03249 A0A8I3NUV3 A0A8I3NUV3_CANLF DIRAS family GTPase 1 DIRAS1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] TYIPTIEDTYRQVIS 1 7.6 0.98508 -0.24506 0 0 10.0881 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NUV5 A0A8I3NUV5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ETWRKGNLYSPELTQ;SETWRKGNLYSPELTQ 2 11 0.99123 -0.13451 0 11.9114 0 0 0 0 0 0 0 0 0 0 0 13.5171 0 A0A8I3NUW1 A0A8I3NUW1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) RPS6KL1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GGTFVVKS 1 1.5 1.0043 -1.1044 0 0 0 0 0 0 0 11.4715 0 0 0 0 0 0 0 A0A8I3NUW9 A0A8I3NUW9_CANLF Thioredoxin domain-containing protein TXNDC5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231] LTEKNFEDTIAEGLTFIKFYAPWCG;PEPAAEPPRAPERKQ;VGPGPLLPPLPPRTSTPLLPWGL;VGRNREKMPKKIRL 4 10 0.99149 -0.27244 0 0 0 0 0 0 0 0 0 4.74389 0 0 0 0 0 A0A8I3NUX3 A0A8I3NUX3_CANLF Polypeptide N-acetylgalactosaminyltransferase like 5 GALNTL5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DHHLEIFRGKIKVIRNKK;DLWGAENLE;FNWHLDFKWDSVYSY;LELSLRIWMCGGQL 4 12.8 1.0017 -0.96465 0 0 0 0 9.41543 5.10421 0 8.97542 0 0 0 0 0 0 0 A0A8I3NUX4 A0A8I3NUX4_CANLF AMP deaminase (EC 3.5.4.6) AMPD3 Canis lupus familiaris (Dog) (Canis familiaris) IMP salvage [GO:0032264] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] KLSTCDLCEIARNSVLQ;METPAPGS;QSLSLQMPTQ;QTFHRFDKFN 4 5.8 1.0033 -1.5627 0 0 0 0 0 0 0 0 0 0 8.76344 0 0 11.2666 0 A0A8I3NUY8 A0A8I3NUY8_CANLF RAR related orphan receptor A LOC119866906 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; muscle cell differentiation [GO:0042692]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; T-helper 17 cell differentiation [GO:0072539]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805] nucleolus [GO:0005730] beta-catenin binding [GO:0008013]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] EAEPLTPTYNI;PLNQESARKSE 2 4.2 0.99416 -0.11979 0 9.30371 0 0 0 0 0 0 15.0842 0 0 0 0 0 0 A0A8I3NUZ0 A0A8I3NUZ0_CANLF Calcitonin receptor CALCR Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of ossification [GO:0030279]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase A signaling [GO:0010739]; regulation of mRNA stability [GO:0043488]; response to amyloid-beta [GO:1904645]; response to glucocorticoid [GO:0051384] acrosomal vesicle [GO:0001669]; amylin receptor complex 1 [GO:0150056]; amylin receptor complex 2 [GO:0150057]; amylin receptor complex 3 [GO:0150058]; axon [GO:0030424]; cilium [GO:0005929] amylin receptor activity [GO:0097643]; amyloid-beta binding [GO:0001540]; calcitonin binding [GO:0032841]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948] WYYLLGWGFPL;YTFSHPTPVLPATSNDTYPP 2 6.5 0.99192 -0.2076 0 0 0 0 0 0 0 0 9.63996 0 0 0 0 0 14.9032 A0A8I3NUZ1 A0A8I3NUZ1_CANLF Serine protease 50 PRSS50 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783] serine-type endopeptidase activity [GO:0004252]; threonine-type endopeptidase activity [GO:0004298] DIPVYQVILNKE;GASALPLLLLLLLLPPPLPP;GPGASALPLLL;HICAGTLI;LLLLLLLL;LLLLLLLLP;LLLLLLLP;PACRTRARGQGRQG 8 13 0.99122 -0.13395 8.78647 0 0 0 0 0 6.52591 8.62385 0 0 0 0 10.1254 0 0 A0A8I3NUZ4 A0A8I3NUZ4_CANLF Rho GTPase activating protein 23 ARHGAP23 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] CCRIVEAR;DAESPGGG;DEPTSPSIDLQAKHVPASAV;ESPGGGGGA;PLFTDDKYNDFIEANRIE;QNSDDTLELSIMPKDEDILQLA;REMLAISFISA;RERMKTLRK;SEDNMADM;TFTFALGRHYSQ;TSPSSPTFTFALGRHYSQ 11 9.1 0.99932 -3.09 10.9215 0 0 8.92309 8.41705 0 7.93958 10.8886 0 8.59137 0 3.91629 0 10.2167 0 A0A8I3NUZ6 A0A8I3NUZ6_CANLF Peptidoglycan recognition protein 2 PGLYRP2 Canis lupus familiaris (Dog) (Canis familiaris) biological process involved in interaction with host [GO:0051701]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; negative regulation of type II interferon production [GO:0032689]; peptidoglycan catabolic process [GO:0009253]; regulation of inflammatory response [GO:0050727] membrane [GO:0016020] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270] ATKEFTEAFLG;GTATLPLL 2 3.1 0.99432 -0.55943 0 6.98618 0 0 0 0 0 0 0 0 0 8.56236 0 0 0 A0A8I3NV01 A0A8I3NV01_CANLF TNF receptor-associated factor PHF19 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] cytoplasm [GO:0005737] tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270] DRICPKCQGDDPQSGS;IDAFRPDLSS 2 6.3 0.99942 -0.61146 0 0 0 0 0 9.32762 0 0 0 0 0 0 0 0 0 A0A8I3NV13 A0A8I3NV13_CANLF Platelet endothelial aggregation receptor 1 PEAR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CPPDTYGVGCSARCSCDNAIAC;CPPGWTGHLCLEGCS;DCDHSDGCDP;EGCASRCDCDHSDGCDPVHGHCQC;FSSKEELGASVASL;HPQHGSCSCPP;RSAPWAASARTAPRRATAPWA;STASAARSPAP 8 11 0.98403 -0.24325 0 0 0 0 0 0 0 0 0 9.58658 0 0 0 0 0 A0A8I3NV16 A0A8I3NV16_CANLF Protein THEM6 THEM6 Canis lupus familiaris (Dog) (Canis familiaris) YLEARFVSLRDGFVCALLRS 1 9.6 0.98256 -0.24826 0 0 0 0 0 0 0 0 0 0 0 0 8.94553 0 0 A0A8I3NV23 A0A8I3NV23_CANLF Olfactory receptor OR9A8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DTLFTEFVL;IICTILRMP 2 5.8 1.0034 -1.6084 0 0 0 0 0 0 0 0 9.63976 0 0 6.92374 0 0 0 A0A8I3NV27 A0A8I3NV27_CANLF Transmembrane protein 114 TMEM114 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327] GALVTLAGISVYIAYSA;SFVAELLT;SGLWRTCRVQSPCVPLMNPFWQENV 3 22.4 1.0022 -1.0171 7.26978 0 0 7.416 0 0 0 0 0 0 7.25758 0 0 0 0 A0A8I3NV30 A0A8I3NV30_CANLF E3 ubiquitin-protein ligase RNF (EC 2.3.2.27) (RING finger protein) RNF5 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503]; negative regulation of autophagy [GO:0010507]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of autophagosome assembly [GO:2000785]; response to bacterium [GO:0009617]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390] HQWLETRPERQECPVCKAG 1 10.6 0.95181 0.049872 0 0 0 0 0 0 0 0 0 0 0 0 0 7.63662 0 A0A8I3NV31 A0A8I3NV31_CANLF PC-esterase domain containing 1A PCED1A Canis lupus familiaris (Dog) (Canis familiaris) FFNYNSTEDFSMSSHLGCGP;HWDQHAHRHLSHLL;SEYLEGVLEEL 3 9.9 0.98786 -0.48507 0 10.7238 0 0 0 0 0 0 6.77255 0 0 0 0 0 0 A0A8I3NV37 A0A8I3NV37_CANLF Neurocan NCAN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] HPPASLDP;HVAIIRCRSNGKWD;NSFGRENTWIGL;RMRRHHHHHQHHH 4 3.8 1.0014 -0.69425 0 0 9.56792 9.42387 0 0 0 0 10.3723 0 0 0 0 0 0 A0A8I3NV42 A0A8I3NV42_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] PLGKWPYLSVDGSTAVLPS 1 6.5 0.95545 0.050712 0 0 0 0 0 9.43619 0 0 0 0 0 0 0 0 0 A0A8I3NV56 A0A8I3NV56_CANLF Translation initiation factor eIF2B subunit beta (eIF2B GDP-GTP exchange factor subunit beta) EIF2B2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851] ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743] SYIYRLMSELYH;VFDYVPPELI;VGNMVRRVLRIIREE 3 10.5 0.99169 -0.20932 4.97701 0 0 0 0 4.30093 7.48768 0 0 0 0 0 0 0 0 A0A8I3NV58 A0A8I3NV58_CANLF Coilin COIL Canis lupus familiaris (Dog) (Canis familiaris) CTVSKSTPEPAAG;EKIAFKEGKILSHNPETQQ;NNNDEKTLDLE 3 7.7 0.9886 -0.50598 0 0 0 0 0 0 0 0 0 0 0 13.1162 0 8.67596 0 A0A8I3NV79 A0A8I3NV79_CANLF Transmembrane protein 150A (Transmembrane protein 150) TMEM150A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LHYIGTGVAFPAGLLFVCLHCALSY;LPVSLSAF 2 12.9 0.98659 -0.23038 0 0 0 0 8.7444 0 0 0 11.2795 0 11.2139 0 0 0 0 A0A8I3NV93 A0A8I3NV93_CANLF HAUS augmin like complex subunit 6 HAUS6 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; spindle assembly [GO:0051225] centrosome [GO:0005813]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498] HVLQREDCVIQKYQENAQLSVKQVR 1 2.6 0.97869 0.035538 0 0 8.73752 0 0 0 0 0 0 0 5.6763 0 0 0 0 A0A8I3NV95 A0A8I3NV95_CANLF "Methyltransferase 15, mitochondrial 12S rRNA N4-cytidine" METTL15 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] ENPRARSAKLRAAIKL;HRPQDRDN 2 5.9 0.95735 0.049233 0 0 0 0 0 0 0 0 0 0 0 5.83532 0 0 0 A0A8I3NV97 A0A8I3NV97_CANLF Voltage-dependent T-type calcium channel subunit alpha CACNA1G Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] DTLRDCDQESTCYNTV;EAELELEMKTLSPQ;KKRRKAQC;LFFIFAAL;LGMLRVLRLLRTLRPLRVI;LMLPPPSTPALSGGPPGGA;LSNYIFTAV;LVHHLCTSHYLDL;RKKRLALVSLGEHPEL;RPASWLDEQRRHS;TENEDENPFICSQP;VGQQGGGL 12 6.6 0.98979 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4983 0 A0A8I3NVA8 A0A8I3NVA8_CANLF Delta/notch like EGF repeat containing DNER Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] GSQGYLCVCNEGYEGPNCEQ;KIDYCILEPCR;LVSFEVPQNTSVKIRQDA 3 6.7 0.99371 -0.16114 10.6122 0 0 8.51286 0 0 0 0 0 6.21896 0 0 0 0 0 A0A8I3NVB0 A0A8I3NVB0_CANLF Zyxin ZYX Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] metal ion binding [GO:0046872] AAPRPPPAISV;AAPRPPPAISVSVS;AAPRPPPAISVSVSAPA;AAPRPPPAISVSVSAPAF;APSPAPKFSPVTPKFTPV;DQANRPHCVPDYHKQYAPRCSVCEG;EEIFPSPPPPPLD;GAPGPLSLKEVQELE;GPPAPSPAPKFSPVTPKFTPVAS;PAAGAQRAQ;SLKEVQELE;SPVTPKFTPVAS;TPKFTPVAS;VSSIDLEIDSLSSL 14 20.5 0 2.6258 11.9708 10.7061 11.3891 11.0477 11.4024 10.705 11.4799 11.6889 11.6236 10.5717 10.5343 10.8701 10.3457 10.7823 9.98527 A0A8I3NVB8 A0A8I3NVB8_CANLF Uncharacterized protein LOC100686711 Canis lupus familiaris (Dog) (Canis familiaris) GAASLQSRTTTSGRAGTSSGSY;YKKWWCRGAYWKSCDILV 2 26.7 0.98857 -0.20402 0 0 10.1694 0 0 0 0 0 0 0 0 0 10.0615 0 0 A0A8I3NVB9 A0A8I3NVB9_CANLF Centromere protein B CENPB Canis lupus familiaris (Dog) (Canis familiaris) "condensed chromosome, centromeric region [GO:0000779]; nuclear body [GO:0016604]; pericentric heterochromatin [GO:0005721]" chromatin binding [GO:0003682]; DNA binding [GO:0003677] EAGGSFGGYG;EDGDEVPVPSFGE;EEDEEDEDDEDEEEDGDEVPVP;EEEDEEDEDDEDEEEDGD;EEEEEDEEDEDDEDEEEDG;EEEEEEEEDEEDEDDEDEEEDGD;EQPPSVAEGYASQDV;GEEEEEEEEEEEEEEEEEEE;RAGMGPKRRQLTFRE;SDSEEEEEEEEDEEDEDDE;VDDSDEEEEEEEEESSSEGL 11 15.1 0.98755 -0.46746 7.17792 0 4.60638 4.0565 4.80854 0 11.1581 8.16214 10.531 0 8.02531 0 0 3.29181 15.0895 A0A8I3NVC7 A0A8I3NVC7_CANLF ABC transmembrane type-1 domain-containing protein ABCD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524] PSAWVCLGAVPFPAGQ 1 8.4 0.99505 -0.15762 0 0 0 0 0 10.6754 0 0 0 7.75902 0 8.2493 8.82614 0 0 A0A8I3NVC9 A0A8I3NVC9_CANLF Calcium dependent secretion activator CADPS Canis lupus familiaris (Dog) (Canis familiaris) dense core granule exocytosis [GO:1990504]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; synaptic vesicle exocytosis [GO:0016079] cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793] AALVNYSRLSEYAKIEENQKD;DLQLHIYQLKTLIRMVKKTYRDFR;EYAKIEENQKDA;LCSMEMGQEHQYH;MTASAASELILSKEQL;NAKQPTDMAR;PTFSAPSWMAAIYDADNGS;TVKDRFQAFL;VLRDKVNEEMYIERLFDQWYNS;VNEEMYIERLFDQWY 10 9.7 1.0019 -1.817 0 0 0 3.99286 10.5118 0 7.77485 0 0 0 7.83238 0 10.7478 6.33278 7.07457 A0A8I3NVD2 A0A8I3NVD2_CANLF Chromosome 18 C7orf25 homolog C18H7orf25 Canis lupus familiaris (Dog) (Canis familiaris) HVFGYTDSLGEKQ;IVESAENLEEVVS 2 6.2 0.98661 -0.45697 0 0 0 0 0 8.47836 9.78875 0 0 0 0 0 0 0 0 A0A8I3NVD3 A0A8I3NVD3_CANLF Potassium calcium-activated channel subfamily N member 3 KCNN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; small conductance calcium-activated potassium channel activity [GO:0016286] IISSREDNHAHQT;KHTKLLKK;KLLKKIDHAKVRKHQ;PAAAPQQSPG 4 5.8 1.0032 -0.7835 9.65746 9.06321 9.05137 11.1362 11.3491 11.0878 0 0 0 8.73407 4.74491 9.32017 8.25096 0 8.08863 A0A8I3NVE6 A0A8I3NVE6_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] LLKARQGGG 1 1.7 0.99227 -0.27195 0 0 12.8507 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NVE7 A0A8I3NVE7_CANLF T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) LOC100856782 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] NILNKLRARHA;QFMEETER 2 5.6 1.0022 -1.3714 0 10.7034 0 0 0 6.83605 0 0 0 0 0 0 0 0 0 A0A8I3NVF0 A0A8I3NVF0_CANLF Glycogen [starch] synthase (EC 2.4.1.11) GYS2 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] cytosol [GO:0005829] glycogen (starch) synthase activity [GO:0004373] TTHNMIDDST;VEDEEEDERYNEE;YLGRYYQH 3 4.4 1.0026 -0.72281 0 0 8.24593 0 0 0 0 0 0 0 7.35279 0 0 0 0 A0A8I3NVF1 A0A8I3NVF1_CANLF Perilipin PLIN2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose starvation [GO:0042149]; lipid droplet disassembly [GO:1905691]; lipid storage [GO:0019915]; long-chain fatty acid transport [GO:0015909] cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; plasma membrane [GO:0005886] PDIIALEEEDGSDHSH 1 3.6 0.96286 0.049233 0 0 0 0 0 0 0 0 0 0 4.30939 0 0 0 0 A0A8I3NVF2 A0A8I3NVF2_CANLF GLIS family zinc finger 1 GLIS1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] FNPLRPNGYHSL;PATGYEALA;PVSQLPPGS;TKPYACQIPGC 4 5.1 1.0014 -0.69918 0 14.062 0 12.4954 12.075 0 14.5903 0 14.7314 0 12.8607 0 14.6218 0 0 A0A8I3NVH0 A0A8I3NVH0_CANLF GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) GCH1 Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; zinc ion binding [GO:0008270] MNSKTVTSTMLGVFREDPKTREEFL 1 10 0.99079 -0.29711 0 0 0 0 0 0 10.7426 0 0 0 0 0 0 0 0 A0A8I3NVH3 A0A8I3NVH3_CANLF Integrin subunit alpha V ITGAV Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] AAVEIRGVSSPDHIF;LPLPLPLPLLLLLPLGLLPRP;PVPVWVIILAVLAGLLLL 3 5.4 0.97997 0.048313 0 0 0 0 0 0 0 0 0 4.53319 0 0 0 0 0 A0A8I3NVH4 A0A8I3NVH4_CANLF Tyrosine-protein kinase (EC 2.7.10.2) JAK2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to lipopolysaccharide [GO:0071222]; collagen-activated signaling pathway [GO:0038065]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; intracellular signal transduction [GO:0035556]; mammary gland epithelium development [GO:0061180]; microglial cell activation [GO:0001774]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; regulation of inflammatory response [GO:0050727]; response to antibiotic [GO:0046677]; symbiont-induced defense-related programmed cell death [GO:0034050]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209] caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; interleukin-12 receptor binding [GO:0005143]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169] AEFMRMIGNDKQG;FYTEQFEVKEPGRGPSGEEIF;KRKESETLTEQDLQ;TKVLPQDKEYY;VTIKQASQEGSNESRIV;YHILTRKRIRY 6 8.2 0.9875 -0.23113 0 0 0 0 0 0 8.07831 6.9438 9.11312 0 0 7.44145 11.021 0 0 A0A8I3NVH5 A0A8I3NVH5_CANLF Immunoglobulin subtype domain-containing protein LOC119863908 Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] EVRPPAPSLKEEETYKAGS;LDCSCDPG;LSFLKRWNGSTA;SALWAAAWRGQ 4 9.6 1.0022 -1.8291 0 0 0 10.0712 0 0 0 0 0 0 0 9.49825 0 9.31141 0 A0A8I3NVJ8 A0A8I3NVJ8_CANLF Transmembrane protein 161A TMEM161A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDEAQQTAALIAG;YKHPTEEELRSLE 2 6.9 0.9437 0.086958 10.8691 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9883 A0A8I3NVK0 A0A8I3NVK0_CANLF Hypoxia inducible factor 1 subunit alpha inhibitor HIF1AN Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of myoblast differentiation [GO:0045663] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] [protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270] QSDPRAEELIENEEPVVLT;VVGYETVVGPGDV 2 8.6 0.99247 -0.18443 0 0 0 0 0 0 0 8.06237 0 10.1369 0 0 0 0 0 A0A8I3NVK6 A0A8I3NVK6_CANLF Heparan-alpha-glucosaminide N-acetyltransferase HGSNAT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGDGGGG;GVNEIACDIVVNKNP;NIVATALWVLIAYILYKK;VGHEVFENYFP;VLIAYILYKKKV 5 8.4 0.99202 -0.13311 10.8672 0 11.093 8.4116 0 0 0 0 0 0 0 0 5.36772 0 0 A0A8I3NVK7 A0A8I3NVK7_CANLF WAS/WASL interacting protein family member 3 WIPF3 Canis lupus familiaris (Dog) (Canis familiaris) "Arp2/3 complex-mediated actin nucleation [GO:0034314]; endocytic recycling [GO:0032456]; exocytosis [GO:0006887]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; WASH complex [GO:0071203] actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015] GLNAEAASPAQD;PPPPTPPP;PSKAPLVSPPGPLTKGNP 3 7.7 0.93978 0.10243 0 0 11.13 7.87141 0 0 0 0 0 0 0 0 0 0 10.9329 A0A8I3NVM7 A0A8I3NVM7_CANLF NADPH oxidase 1 NOX1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] oxidoreductase activity [GO:0016491] KWILAPGV;LSYEKADKYYYTR;LVLMVTSAMEFIRRSYFEVFWYT;NFERYSRSR 4 10.3 0.94025 0.05971 0 0 0 0 0 0 0 8.76799 0 0 0 0 0 0 0 A0A8I3NVM8 A0A8I3NVM8_CANLF IQ motif containing F1 IQCF1 Canis lupus familiaris (Dog) (Canis familiaris) acrosomal vesicle [GO:0001669] LVRRTLLHAVIRVMVIQRWWKQIL 1 11.6 0.97347 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 6.32214 0 0 A0A8I3NVN7 A0A8I3NVN7_CANLF Transmembrane channel-like protein TMC2 Canis lupus familiaris (Dog) (Canis familiaris) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005] plasma membrane [GO:0005886]; stereocilium tip [GO:0032426] mechanosensitive monoatomic ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245] ADNKYVSITTSF;RKETRKRPKKHR 2 2.6 0.98897 -0.20398 0 0 0 0 0 0 0 0 0 0 0 0 10.2852 0 9.60134 A0A8I3NVP5 A0A8I3NVP5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] ELRDYTVSLCESGQLAF;FIPWFSIYFGGKHLE;HRILAFFLL;KTFCSLSFA;SKIWKLML 5 17.5 1.0023 -1.2363 0 0 12.6373 0 0 9.11757 0 0 10.7534 0 0 0 0 0 0 A0A8I3NVP6 A0A8I3NVP6_CANLF DLG associated protein 5 DLGAP5 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616] ELDETSQNLVPEKA;LPSERMNLP;QSVFDTRSLT;SFGDYIIAYEAL;VMTTSVRLTRSA;VTKEILTQECKTY 6 8.2 1.0032 -2.1085 0 0 0 10.8983 0 0 0 0 8.86888 0 0 0 11.5164 11.9836 0 A0A8I3NVQ6 A0A8I3NVQ6_CANLF Aminopeptidase (EC 3.4.11.-) NPEPPS Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytosol [GO:0005829] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] DEIFDAISYSKGASVIRMLHDYI;DHCFPEYDIWT;EVLKVMEA;LLSHTDFYEEIQEFVKDVF;MNMYLTKFQQ;PPLLLLLL;PPPPPLLLLLLSRSSRRRRRLHSL;SEEVRPQDT;SVIRMLHDYIG;TVGFYRTQY;VSADYTRAQELDALD;YSLCLKPDLLDFTFE 12 15.6 1.0027 -1.8507 11.0962 0 10.5635 0 10.0708 10.695 11.1719 12.2035 0 10.1803 0 5.62778 5.05589 10.8381 10.6347 A0A8I3NVR2 A0A8I3NVR2_CANLF Multiple C2 and transmembrane domain containing 1 MCTP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of neurotransmitter secretion [GO:0046928] synaptic vesicle membrane [GO:0030672] calcium ion binding [GO:0005509] DMLEDEEEEDDKDDK;DVPLADPG;EEKACILVEHLRE;IPLRYIVLVWGI;KGKGGGGA;KSWKRSSKDLSENEVVGSY;PLEPGGGG;VGKGKGGG 8 8.9 0.99751 -3.7375 9.32874 0 10.2148 10.5704 10.8623 10.8921 9.38061 0 0 10.0783 9.76424 9.66327 1.83078 10.4265 0 A0A8I3NVU5 A0A8I3NVU5_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] KLPKQPVIEKIKGV 1 13 0.94112 0.060769 0 0 0 0 0 0 0 0 0 0 0 4.85704 0 0 0 A0A8I3NVV2 A0A8I3NVV2_CANLF Leukocyte cell derived chemotaxin 2 LECT2 Canis lupus familiaris (Dog) (Canis familiaris) identical protein binding [GO:0042802]; metal ion binding [GO:0046872] EKLGTLLPLQKVY 1 8.6 0.99011 -0.27352 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5654 A0A8I3NVV8 A0A8I3NVV8_CANLF SH2 domain containing 6 SH2D6 Canis lupus familiaris (Dog) (Canis familiaris) EPSPVLALTQ 1 4.3 0.99993 -0.61146 0 0 0 0 0 0 7.35085 0 0 0 0 0 0 0 0 A0A8I3NVX3 A0A8I3NVX3_CANLF Macrophage scavenger receptor 1 MSR1 Canis lupus familiaris (Dog) (Canis familiaris) receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] membrane [GO:0016020] scavenger receptor activity [GO:0005044] KGQKGDKGSGSMLSTGPIW;LKSLKAALIILYLLVFVVLIPII;RFQEVVMEQMSN;SIEECKIRQWG 4 16.6 0.98965 -0.31563 10.579 11.7647 0 9.70394 0 11.9911 12.5235 11.33 0 0 8.69331 0 0 0 0 A0A8I3NVX5 A0A8I3NVX5_CANLF Small integral membrane protein 18 SMIM18 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLYEVLDCCCC 1 11.2 0.98219 -0.25051 0 0 0 9.78563 0 9.60947 0 0 0 0 0 10.1223 0 0 0 A0A8I3NVX7 A0A8I3NVX7_CANLF nucleoside-diphosphate kinase (EC 2.7.4.6) NME1 Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] nucleoside diphosphate kinase activity [GO:0004550] PVVAMFTDFL 1 12 0.98176 -0.24938 0 0 0 0 0 0 0 0 0 0 0 0 12.71 0 0 A0A8I3NVY0 A0A8I3NVY0_CANLF Discs large MAGUK scaffold protein 3 DLG3 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] neuromuscular junction [GO:0031594]; neuron projection [GO:0043005] kinase binding [GO:0019900] GVNDCVLRVNE;VSEVVHSRAVE 2 2.7 0.98973 -0.26595 0 0 0 8.92769 0 0 0 0 0 0 8.5606 0 0 0 0 A0A8I3NVY1 A0A8I3NVY1_CANLF Zinc finger MIZ-type containing 2 ZMIZ2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255] zinc ion binding [GO:0008270] AGSPPGGSVMPGMAGS;FLGPGTFPDSFP;PAGSPPGG;RGTWRCPVCNSDY;SPAHVLMPSVMEMIAAL;YPGGPGFTPGYAGGPG;YPGQQYLPG 7 9.4 1.0021 -2.6099 11.1362 0 14.2583 6.85823 0 0 11.3041 10.3858 0 0 0 0 12.2913 0 0 A0A8I3NVY8 A0A8I3NVY8_CANLF KH-like RNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ENFYLPLVFYMEEDQEECI;FGHLCIEVHSHTFIQLQ;WIVSENFYLPLVFYMEE 3 33.1 0.99475 -0.12932 0 0 8.94158 0 0 0 0 10.8244 0 0 0 0 0 6.26673 0 A0A8I3NW12 A0A8I3NW12_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK9 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cell cycle [GO:0000278]; regulation of mitotic cell cycle [GO:0007346] centrosome [GO:0005813]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] DALNEIVILAL;GGGGGGGE;HACLDQDPEQRPTAD;IRTIAPGKTHTAAID;KQLSFYKI;MSVLGEYERHC;PGGGGGGG;PGPRGGGGA 8 7.9 1.0027 -1.5078 8.19096 7.8568 7.54736 0 0 0 0 0 10.0996 0 0 0 0 0 0 A0A8I3NW13 A0A8I3NW13_CANLF Uncharacterized protein LOC102154767 Canis lupus familiaris (Dog) (Canis familiaris) VPTECQEDEACG 1 17.4 0.95354 0.05044 0 0 7.23103 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NW16 A0A8I3NW16_CANLF Protein kinase C and casein kinase substrate in neurons 2 PACSIN2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; protein localization to endosome [GO:0036010] caveola [GO:0005901]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587] cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phosphatidic acid binding [GO:0070300] QNKPSSDLSVPSNPARSAQ;VFEQCQQFE 2 5.8 0.9516 0.049853 0 0 0 0 0 0 0 0 5.93291 0 0 0 0 0 0 A0A8I3NW24 A0A8I3NW24_CANLF Transcription factor like 5 TCFL5 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] AAGGFAAAAAG;AAGGGGAA;ELRMMLLSEAGAPAAPA;LADGGFAG 4 8.8 0.99232 -0.1842 8.50764 0 0 0 0 0 0 0 9.83805 4.32351 0 0 0 5.40126 0 A0A8I3NW28 A0A8I3NW28_CANLF Protein O-mannose kinase (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196) POMK Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation [GO:0006493] endoplasmic reticulum membrane [GO:0005789] ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; protein kinase activity [GO:0004672] RTEVRPLKRIGEGAVKRVFLSEWKE 1 7.1 0.97875 0.035538 5.60621 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NW29 A0A8I3NW29_CANLF UBC core domain-containing protein CDC34 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin conjugating enzyme activity [GO:0061631] DLFYDDYY;GGGGGGGE;GGGGGGGG;GGWRPGPG;PGGGGGGG;YYEDGEAEAEADSCFGDDEDD 6 9.6 1.0033 -1.5684 0 0 0 6.13132 0 0 0 0 0 0 9.24909 0 0 0 0 A0A8I3NW30 A0A8I3NW30_CANLF Sperm tail PG-rich repeat containing 1 STPG1 Canis lupus familiaris (Dog) (Canis familiaris) KILKKTLILK 1 3.5 0.99986 -0.61146 0 0 0 0 0 0 0 0 0 4.10467 0 0 0 0 0 A0A8I3NW45 A0A8I3NW45_CANLF TLC domain containing 4 TLCD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] STVFTSFFT;YFIIHHCAALYAYYYVLR 2 10.3 0.99127 -0.14548 0 0 6.69794 0 0 0 0 0 0 0 8.08953 0 0 0 0 A0A8I3NW46 A0A8I3NW46_CANLF Olfactory receptor family 1 subfamily A member 1 OR1A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGVGVFSVPL 1 3.2 0.98737 -0.22805 0 0 0 0 10.7841 0 0 0 0 13.1362 0 13.2766 0 0 0 A0A8I3NW51 A0A8I3NW51_CANLF Dynein 2 intermediate chain 1 DYNC2I1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721] ciliary base [GO:0097546]; cytoplasmic dynein complex [GO:0005868]; interphase microtubule organizing center [GO:0031021]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] AACFEDDFEDYEDDFEVCDGDD;AACFEDDFEDYEDDFEVCDGDDD;CDGDDDSSN;ENAGADEYAACFEDDFEDYE;FEDDFEDYEDDFEVCDGDDDSS;FEDYEDDFEVCDGDDDSSNELE;HSTTIQLSDSLCQKG;LDVPEYKDQK;VLSPSSMQEEMS;YAACFEDDFEDY 10 7.5 0.99839 -0.60439 0 0 9.13843 0 9.35586 6.86678 0 0 7.9458 0 5.58412 9.49673 11.0604 5.13582 0 A0A8I3NW53 A0A8I3NW53_CANLF ER lumen protein-retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) KDELR2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031] cis-Golgi network [GO:0005801]; COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] ER retention sequence binding [GO:0046923] DTFRVEFLVVPVGGLSFL;QRHKMLDTENQKLN;YLIYMKFKATYD 3 23.5 0.86689 0.16214 0 5.76344 0 0 0 0 0 0 10.3572 0 0 0 0 0 0 A0A8I3NW55 A0A8I3NW55_CANLF Uncharacterized protein LOC100686511 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; sialic acid binding [GO:0033691] CLIFFRVK;SVPWACEQGIPPIFS;VLTLTPRPQDHGTNLTCQVQFP 3 11.9 1.0026 -0.71464 0 10.0577 0 0 0 0 0 9.16777 0 0 0 0 0 0 0 A0A8I3NW58 A0A8I3NW58_CANLF Peptidyl-cysteine S-nitrosylase GAPDH LOC106560188 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" GVSAPSADAPMFVI;GVSAPSADAPMFVIG 2 4.2 0.99244 -0.175 0 0 0 0 4.17225 0 0 13.212 0 0 0 0 0 0 0 A0A8I3NW65 A0A8I3NW65_CANLF Phospholipase C zeta 1 PLCZ1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; single fertilization [GO:0007338] perinuclear region of cytoplasm [GO:0048471] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] AAGLPLFKRRR;YFISSSHNTYLISDQ 2 4.3 0.99191 -0.18523 0 0 0 0 0 0 0 0 9.51714 0 5.19566 0 0 0 0 A0A8I3NW77 A0A8I3NW77_CANLF Elongation factor 1-alpha Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] TRPTDKPLHL 1 2.2 0.99136 -0.27563 0 8.94489 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NW78 A0A8I3NW78_CANLF Olfactory receptor OR2T11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLMLLIPISIISTSYSLILLT 1 6.6 0.97482 0.047166 0 0 0 0 0 0 3.88147 0 0 0 0 4.22435 0 0 6.86394 A0A8I3NW85 A0A8I3NW85_CANLF Uncharacterized protein OR10N1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AEGRQKAFSTCSAHLTAIL 1 6.2 0.95018 0.049702 0 0 0 0 0 0 0 0 0 0 0 6.76288 0 0 0 A0A8I3NW88 A0A8I3NW88_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRZ1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DSDDYDDDDDD;EPGAWAVVAGDEES;GALGPAADPQGSTVSRATEKSFE;GDDGDSDDYDDD;GDDGDSDDYDDDD;GDDGDSDDYDDDDD;GDDGDSDDYDDDDDD;GDSDDYDDDD;GGDDGDSDDYDDDDDDR;IGWSYTGALNQKNWGK;LTITSELV;LVGGGDDGDSDDYDDDDDDR;LVGGGDDGDSDDYDDDDDDRE;REFLTDGYQ;SPGSGGSR;VGGGDDGDSDDYDDDDD;VGGGDDGDSDDYDDDDDD;VSRATEKSFE 18 5.5 1.0022 -1.2213 10.4977 0 0 0 0 0 9.88975 8.47905 0 0 0 0 0 8.82037 8.724 A0A8I3NWA7 A0A8I3NWA7_CANLF Transmembrane protein 59 TMEM59 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of autophagy [GO:0010508] Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] CQRGCRLFSICQFV;DTASCHRACQLTFP 2 19.4 0.98261 -0.25007 0 0 0 0 0 0 8.17193 0 0 0 0 0 0 0 0 A0A8I3NWB1 A0A8I3NWB1_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC486765 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FSALMLMVPYYQLQ;GALLVYSLLAFSVLILRYEPQ;LTEEDYIKAGLNDTSSLGPLG;SIVICLLVASL;SLLDYMFPIRQLISMMAHY 5 14.2 0.99517 -0.017962 0 0 0 0 0 8.16596 5.0558 10.0199 0 0 0 0 0 10.0773 0 A0A8I3NWB4 A0A8I3NWB4_CANLF RING-type domain-containing protein RNF122 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFVPGGAS;GGGKQRGS 2 3.8 1.0022 -1.3701 0 0 6.05866 0 0 0 7.60696 0 0 0 4.71913 0 6.80516 0 0 A0A8I3NWB7 A0A8I3NWB7_CANLF Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 PYROXD1 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] FFNYKVVLL;GVTPNTEPFLCGNNFDLGED;MMGAVLIGETDLEE;TTDKEAWP;VELTNEKTYGCD 5 13.7 1.0035 -1.6011 8.75979 0 0 9.78374 0 0 0 0 0 9.97183 0 0 0 0 0 A0A8I3NWC3 A0A8I3NWC3_CANLF "XPA, DNA damage recognition and repair factor" XPA Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; protein localization to nucleus [GO:0034504]; UV protection [GO:0009650] DNA replication factor A complex [GO:0005662]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837] LEDDMYRKTCTVCGHE;LKFIVKKNP 2 9.2 1.0029 -0.75498 9.64679 0 0 0 0 0 0 0 5.74373 0 0 0 0 0 0 A0A8I3NWD5 A0A8I3NWD5_CANLF Olfactory receptor OR14I2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSFLDLCYVSVTVPK;LVIAVAYTVLPPFLNPIIYS 2 11.2 0.9321 0.10549 10.0757 0 0 0 0 0 4.72661 0 0 0 0 0 0 0 0 A0A8I3NWE2 A0A8I3NWE2_CANLF Olfactory receptor OR5B3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;YIFGFLNASI 2 7.4 0.99942 -0.61146 0 0 9.3085 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NWF0 A0A8I3NWF0_CANLF Yip1 domain family member 7 YIPF7 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] cytoplasm [GO:0005737]; membrane [GO:0016020] LPMVILSGCGLVFSL 1 5.9 0.94815 0.080592 0 6.17828 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NWF2 A0A8I3NWF2_CANLF Proline rich transmembrane protein 1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPPADAQA;PAPTAVEHRP 2 7 1.0025 -1.357 0 0 0 11.1608 0 8.07585 0 0 0 0 0 0 0 0 0 A0A8I3NWF5 A0A8I3NWF5_CANLF Neurofilament medium polypeptide (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) NEFM Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ECHSDQNMHQAEEW;EEVADLLAQI;GVCRTGGKWGEGRQVVLQ;KDVPEKKKAE;SAKEEIAEYRRQLQSKSIELE;TVTQKVEEHEETF 6 7.9 1.003 -1.3335 0 0 0 0 0 0 8.26632 0 11.2401 0 9.86408 5.02857 4.89816 0 10.8727 A0A8I3NWG1 A0A8I3NWG1_CANLF Transcription termination factor 1 TTF1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; DNA binding [GO:0003677] AADKKKHKKKKRKI;KKKHKKKKRKISHHQ;KRKDFQHL;LVDKENIENTPKNFRR;MFRYLTAWFTPE;MYRDDLGRFKEFKAQ;SEVGTAGR;VGTAGRVKKKSKKRKRRS 8 9.9 1.0046 -1.0942 0 0 0 0 0 0 14.5236 10.0366 6.46256 0 5.43159 0 8.94854 4.11086 0 A0A8I3NWG4 A0A8I3NWG4_CANLF Syndecan 4 SDC4 Canis lupus familiaris (Dog) (Canis familiaris) inner ear receptor cell stereocilium organization [GO:0060122]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; regulation of fibroblast migration [GO:0010762]; wound healing [GO:0042060] cell surface [GO:0009986]; membrane [GO:0016020] identical protein binding [GO:0042802]; thrombospondin receptor activity [GO:0070053] TEVIDPQDLLEGRYFSG 1 8.4 0.98983 -0.20132 0 0 0 0 0 0 0 0 0 10.302 0 0 0 0 0 A0A8I3NWG7 A0A8I3NWG7_CANLF Protein phosphatase 1 regulatory subunit PPP1R12B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; stress fiber [GO:0001725] phosphatase regulator activity [GO:0019208]; protein kinase binding [GO:0019901] ELNVQDYDGWTPLHAAAHW;ILAEALCDMDVRNKLG;LERKMSEMEEEMKNLHQLKQ;SEMEEEMKNLH 4 5.2 0.99236 -0.19337 0 0 0 0 8.79588 0 0 0 0 15.1368 0 0 0 0 0 A0A8I3NWH1 A0A8I3NWH1_CANLF DnaJ homolog subfamily C member 5B DNAJC5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCCCNCCCGRCRPKSSVPEE;CCCLCCCCN;CCCLCCCCNCCCGRCR;CCCLCCCCNCCCGRCRP;CCCLCCCCNCCCGRCRPKSS;CCCNCCCGRC;CCLCCCCNCCCG;CCLCCCCNCCCGRCR;CYFCCCLCCC;CYFCCCLCCCC;CYFCCCLCCCCNCCC;CYFCCCLCCCCNCCCGR;CYFCCCLCCCCNCCCGRC;FCCCLCCCC;FCCCLCCCCNC;FCCCLCCCCNCC;FCCCLCCCCNCCCGR;FCCCLCCCCNCCCGRC;FCCCLCCCCNCCCGRCR;GCYFCCCLCCC;GCYFCCCLCCCC;GCYFCCCLCCCCNCCCG;KYGSLGLYVAEQFGDENVN;LCCCCNCCCG;LTGCYFCCCLCCCC;TGCYFCCCLCCC;TGCYFCCCLCCCCNCCCG;TGCYFCCCLCCCCNCCCGR;TGCYFCCCLCCCCNCCCGRC;TGCYFCCCLCCCCNCCCGRCRP;VIIGLLTGCYFCCCLCCCCNCCCGR;YFCCCLCCCCNCCC 32 27.1 1.0028 -2.5236 8.49077 9.25193 11.3665 6.16223 7.6435 5.6104 6.69864 9.31184 5.60419 8.0177 3.55912 9.64267 7.71692 6.55981 7.73064 A0A8I3NWH3 A0A8I3NWH3_CANLF "Glucosidase alpha, neutral C" GANC Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] LIREAIRQRYALLPYWY;NWEHRELHNIY;WEHRELHNIYG 3 3.4 0.99433 -0.1618 0 0 9.54073 0 0 8.54643 0 9.52754 0 0 0 0 0 10.1127 0 A0A8I3NWH9 A0A8I3NWH9_CANLF Kinase suppressor of ras 1 KSR1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] AFGTVWYELQ;KLKPPRTPPPPSRKV;QRDSRFNFPDISAFPQ 3 4.9 0.99182 -0.27018 0 0 0 0 0 0 10.9825 10.7805 0 0 0 0 0 0 0 A0A8I3NWI4 A0A8I3NWI4_CANLF Rho guanine nucleotide exchange factor 11 ARHGEF11 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; membrane [GO:0016020] G protein-coupled receptor binding [GO:0001664]; guanyl-nucleotide exchange factor activity [GO:0005085] GDILAPMDFALNTYMN;LDLHVLLLEDLLVLL;LEDVERLRHLILCSL;LIIGPEEDYDPGY;QPTSEPEDDL;SLDSQEGDSGMDSG;SLDSQEGDSGMDSGTERLPS 7 5.8 1.0028 -0.85414 0 0 10.0784 7.79123 0 0 0 12.3218 0 6.89833 0 0 9.10037 0 6.64171 A0A8I3NWI6 A0A8I3NWI6_CANLF Family with sequence similarity 172 member A FAM172A Canis lupus familiaris (Dog) (Canis familiaris) "neural crest cell development [GO:0014032]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] DELMKKDEPPLDFPD;FVAHSYGGLAFVELMIQ;SEPLDTSVESMLPDCPR 3 11 0.99514 -0.011274 10.4243 0 0 0 0 6.52086 11.8346 0 0 0 0 0 0 0 0 A0A8I3NWJ4 A0A8I3NWJ4_CANLF Dynamin-1-like protein (EC 3.6.5.5) DNM1L Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; rhythmic process [GO:0048511] clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; peroxisome [GO:0005777]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017] EADGKVAAGGGGV;KSKPIPIMPASP;LARTLNRLL;PEDKRKTTGEENGVEAEEWGKFLHT;TTGEENGV;VELVHEEM 6 9.2 0.99723 -3.8812 10.5867 0 0 0 0 0 14.438 0 0 0 7.88007 10.117 0 12.3068 0 A0A8I3NWJ6 A0A8I3NWJ6_CANLF Cyclin I CCNI Canis lupus familiaris (Dog) (Canis familiaris) AGRQADPKDIMKFPGPLE;EEEEEEEEEEEEEK;RIPVLKVL;TPLDFLHIFHAIAVSTRPQLLFS;YPETFALASSLL 5 17.8 1.0016 -1.2499 0 0 0 0 0 8.34607 7.81794 12.9943 6.68622 0 0 0 0 0 0 A0A8I3NWK0 A0A8I3NWK0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LQGRAGLLDSGHGPESG;PESGRAGGRSPAQGPRVSPA 2 14.3 0.92787 0.095644 0 0 0 0 0 0 0 0 9.10515 0 0 0 10.6296 0 0 A0A8I3NWL0 A0A8I3NWL0_CANLF Oxytocin-neurophysin 1 OXT Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] neurohypophyseal hormone activity [GO:0005185] GPGHKKAG;LDVRQCLPCGPG 2 11 1.0017 -1.2861 6.46428 0 0 0 0 0 0 12.4563 12.417 0 0 0 0 0 0 A0A8I3NWL3 A0A8I3NWL3_CANLF Olfactory receptor OR5B21 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVAPKAVAALQSGNKVI;QPSSSQSMDTDKIDSVFYSV 2 11.6 0.99296 -0.18804 0 0 0 0 0 0 0 0 0 0 9.7865 0 0 0 0 A0A8I3NWM8 A0A8I3NWM8_CANLF Chloride channel protein CLCN1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated chloride channel activity [GO:0005247] CQGCVRRLGH;EQSWWGSAPQYQYMPFEHC;GVLALEELQKAIE;IVTFIIASFTFP;LVDNMSPEEIEA;TAGLGSGI;TDEEDEDEL;WVKHVGDPESL;YMPFEHCTSYG 9 10.4 1.0035 -1.6849 0 0 0 0 8.28674 8.1572 0 10.1372 9.87895 0 7.56499 3.66585 5.26664 0 6.10965 A0A8I3NWN6 A0A8I3NWN6_CANLF S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) MTAP Canis lupus familiaris (Dog) (Canis familiaris) L-methionine salvage from methylthioadenosine [GO:0019509]; purine ribonucleoside salvage [GO:0006166] cytoplasm [GO:0005737]; nucleus [GO:0005634] S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] CYASIAMATDYDCW 1 4.9 0.99072 -0.2677 0 0 0 13.3511 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NWP4 A0A8I3NWP4_CANLF MAF bZIP transcription factor A MAFA Canis lupus familiaris (Dog) (Canis familiaris) insulin secretion [GO:0030073]; response to glucose [GO:0009749] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAAGPPGGGPGAGGGA;AAAHGGAGL;EVIRLKQKRRTL;GAGGGGGG;GGGAAGKP;GGGGGGGA;RLKQKRRTLKNRGY;STPCSSVPSSPSFCAPSPGTG 8 22.3 1.0026 -1.7778 7.5108 0 14.76 9.89842 10.0888 9.89692 0 0 0 0 0 0 9.252 0 0 A0A8I3NWR2 A0A8I3NWR2_CANLF Cytochrome b5 reductase 4 CYB5R4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QYRHPVRLFWPKSKCYD;SQYRHPVRLFWPKS 2 6.1 0.99133 -0.5136 0 9.37082 0 0 0 8.43925 0 0 0 0 0 0 0 0 0 A0A8I3NWS3 A0A8I3NWS3_CANLF UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) MFSD11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] QPDSENVLGEDESSDDQ;VGTVLFFLI 2 6.5 0.98979 -0.19647 0 0 12.0015 0 0 0 0 8.00607 0 0 0 0 0 0 0 A0A8I3NWS6 A0A8I3NWS6_CANLF RasGEF domain family member 1B RASGEF1B Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] LRLLLLLLCHAQI 1 2.7 0.94004 0.059615 0 0 0 0 0 0 0 0 0 4.21684 0 0 0 0 0 A0A8I3NWU1 A0A8I3NWU1_CANLF Transmembrane protein 225 TMEM225 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IMMILCLSLSFV;KSTSACAC 2 8.8 1.0024 -1.3681 0 0 0 0 0 0 0 11.0575 0 0 0 0 6.47166 0 0 A0A8I3NWU3 A0A8I3NWU3_CANLF Nudix hydrolase 9 NUDT9 Canis lupus familiaris (Dog) (Canis familiaris) ADP catabolic process [GO:0046032] cell junction [GO:0030054]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965] ADP-ribose diphosphatase activity [GO:0047631] NLTLEAGD 1 2.3 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 7.23266 0 0 0 0 0 A0A8I3NWU6 A0A8I3NWU6_CANLF PBX homeobox 2 PBX2 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; proximal/distal pattern formation [GO:0009954] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YHSELEKYEQACNEF 1 3.5 0.95672 0.053874 7.27249 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NWV5 A0A8I3NWV5_CANLF Sterile alpha motif domain containing 14 SAMD14 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; neuron projection development [GO:0031175] actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; postsynaptic density [GO:0014069] actin filament binding [GO:0051015] DLDLAVPETVRLDS 1 3.4 0.98449 -0.25508 0 0 0 0 9.69049 0 0 0 0 0 0 0 0 0 0 A0A8I3NWW6 A0A8I3NWW6_CANLF Uncharacterized protein MAGEB4 Canis lupus familiaris (Dog) (Canis familiaris) AASATKASAHSRATSS;VGLLVQFMLYKYKLKEPIKK 2 10.5 0.98783 -0.22419 0 0 0 5.39633 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NWW7 A0A8I3NWW7_CANLF "Long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.8)" ACADL Canis lupus familiaris (Dog) (Canis familiaris) long-chain fatty acid catabolic process [GO:0042758] mitochondrial matrix [GO:0005759] flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466] EFMFEETRNY;TEPGAGSD 2 4.5 0.99906 -0.61146 0 0 0 0 0 0 0 0 0 0 9.32513 0 0 0 0 A0A8I3NWY3 A0A8I3NWY3_CANLF Nucleosome assembly protein 1 like 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] EEKNEEEEE;NEKPDKRA;QEVDEYQSPDFEYEFGNEEESE;QSPDFEYEFGNEEESESEE;RDFHDLEKKY 5 13.8 1.0008 -2.7272 6.71507 0 5.16764 0 0 9.50577 0 0 0 0 8.5988 8.02702 0 0 0 A0A8I3NWZ2 A0A8I3NWZ2_CANLF Hydroxysteroid 17-beta dehydrogenase 11 HSD17B11 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]" IILDLLLLLLTIIYSYL;TVASVCGHGV 2 10.2 0.9861 0.046227 0 0 0 0 0 8.32333 0 0 0 0 0 0 0 0 0 A0A8I3NWZ3 A0A8I3NWZ3_CANLF DENN domain containing 5B DENND5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] GIDADSGL;GVYEPVICQRPGPN;IRLSLEKKLLSQ;LDAPVPYLMG;QFHSFIITREDG;TGLEENTLIASLCDL 6 5.6 1.0016 -1.3147 8.95994 0 0 0 9.26805 0 11.8507 10.2291 0 0 0 0 0 0 0 A0A8I3NWZ8 A0A8I3NWZ8_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LYALLQLHFCGPNVI;SWSVDLITLIKMESY;SYVLVIMISYGYIVATILKITSA 3 18 0.97875 0.046253 0 0 0 0 0 0 0 0 0 6.29818 0 0 0 0 0 A0A8I3NX10 A0A8I3NX10_CANLF Uncharacterized protein TSPAN14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CWYKYLLFSYNIVFWNQ 1 11.6 0.9766 0.046227 0 0 0 0 0 0 0 8.69888 0 0 0 0 0 0 0 A0A8I3NX17 A0A8I3NX17_CANLF Golgi phosphoprotein 3 like GOLPH3L Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030]; positive regulation of protein secretion [GO:0050714] cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580] phosphatidylinositol-4-phosphate binding [GO:0070273] DTNEDRGPDNEDS;ELDPEVEGTKHSATEMIWAV;FKLQYQLRNV;KKRLLDRKVLLKSDSP;KYDVAMNRAKDL 5 24.9 1.0036 -1.0422 0 3.72225 0 0 0 0 10.1372 10.7693 0 0 8.47533 0 3.04597 0 0 A0A8I3NX24 A0A8I3NX24_CANLF Uncharacterized protein PLEKHB2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LYDETTVASSPP;TILKRWKKNWFDLWSDGHLIYYD;VGSEVLYDETTVASSPP 3 22.5 0.99066 -0.51582 0 0 0 0 0 0 0 0 0 0 9.30485 0 0 10.8147 0 A0A8I3NX26 A0A8I3NX26_CANLF MOB kinase activator 3B MOB3B Canis lupus familiaris (Dog) (Canis familiaris) regulation of hippo signaling [GO:0035330] cytoplasm [GO:0005737] KHFYYFVTEM;KHFYYFVTEMNLIDRKELEPL 2 9.7 0.99419 -0.56166 0 0 0 8.16405 0 0 0 0 4.20844 0 0 0 0 0 0 A0A8I3NX31 A0A8I3NX31_CANLF Uncharacterized protein DLGAP2 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] EKRHGRFKR;NVNGTKGDGRVEDH;PSLRPCHYLQ;QSYMRAVSTLSQAS;TAQSSTEST 5 5.2 1.0031 -2.3359 0 0 0 0 0 0 0 0 0 0 0 0 0 9.66825 0 A0A8I3NX44 A0A8I3NX44_CANLF Even-skipped homeobox 2 EVX2 Canis lupus familiaris (Dog) (Canis familiaris) limb morphogenesis [GO:0035108] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" EIDTLFNLQH;GGGGGGGA;GGGGGGGG;HPGLYQTP;SGSAAGTT;SRGGGGGGG 6 11.6 1 -2.8202 10.2928 0 0 7.22516 8.55121 0 0 0 0 0 0 0 0 0 8.55995 A0A8I3NX47 A0A8I3NX47_CANLF Eukaryotic translation initiation factor 4 gamma 2 EIF4G2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; regulation of translational initiation [GO:0006446] cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281] mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743] AEDAPNFDGPAAEG;GVREMRAPKHFLP;KELPARIRF;LGGLADMFGQMPGS;LILKGVILLIVD;PAKTSKKPPPSKEELL;PARSTRRDDNS;QQSKVNMQKMLPEIDQNKDRM;QVPKLQPQITMIPPSA;VFLPRSKQNFI;VGVESKLILKGVILLIV 11 14.3 0.98426 -0.25342 0 0 0 0 0 0 10.8123 0 0 0 0 0 0 0 0 A0A8I3NX59 A0A8I3NX59_CANLF LDL receptor related protein 8 LRP8 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] CDEDDDCSDNSDE;CDEDDDCSDNSDEDD;CDEDDDCSDNSDEDDC;CDGDDDCGDGSDERGCAD;CDGDDDCGDGSDERGCADPA;CDGEEECPDGSDESEAT;CDGEEECPDGSDESEATCT;CDGEEECPDGSDESEATCTKQVCP;DDDCGDGSDERGCADPACG;DDDCSDNSDED;DDDCSDNSDEDDC;DEDDCPKKTCADSDF;DEDDDCSD;DEDDDCSDNSDEDDCPKKTCAD;DGDDDCGDGS;DGDDDCGDGSDE;DGDDDCGDGSDERG;EDDDCSDNSDED;EDDDCSDNSDEDD;EDDDCSDNSDEDDC;EDDDCSDNSDEDDCP;EDPDACSQICVNYKGYFKCECHPGY;FVCDGDDDCGD;IPSVWRCDEDDDCSDN;RCDEDDDCSDNSDEDDC;RCIPSVWRCDEDDDCSDNSDEDDC;RCPRTRLTPPLPGAGPAKVCE;VCDGDDDCGD;VWRCDEDDDCSDNSDEDDCP;WRCDEDDDCSDNSDEDDCPKKTCAD 30 12.7 0.96555 0.04865 0 0 0 0 6.13155 0 0 0 0 0 0 0 0 0 0 A0A8I3NX64 A0A8I3NX64_CANLF Ras association domain family member 9 RASSF9 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; endosome [GO:0005768]; trans-Golgi network transport vesicle membrane [GO:0012510] DSLLQMKAKEYEFL;EGAAAGELESSNLEN;KRIVRKTFRKLAKIK;LEERLAYY;PPDKQKRIVRK;QKRIVRKTFRKLAKIKQ;SERVLPPLTRILKL 7 16.6 0.98962 -0.27373 0 0 0 8.44328 0 9.28861 8.93967 9.2632 9.11192 5.45904 4.90828 0 11.1924 9.11056 10.5772 A0A8I3NX66 A0A8I3NX66_CANLF Sulfiredoxin (EC 1.8.98.2) SRXN1 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] cytosol [GO:0005829] ATP binding [GO:0005524]; sulfiredoxin activity [GO:0032542] YQQLQRET 1 5.8 0.9873 -0.2351 0 9.26045 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NX77 A0A8I3NX77_CANLF Solute carrier family 35 member C2 SLC35C2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of gene expression [GO:0010629]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked fucosylation [GO:0036066]; UDP-glucose transmembrane transport [GO:0015786] cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane [GO:0016020]; nucleoplasm [GO:0005654] antiporter activity [GO:0015297] AALVLVVLLIAGGLFMFTYKSTQF;ISLHVALKALHSR;SSRPEEDDNEEEEEE 3 14.1 0.99235 -0.17818 0 0 3.54077 5.93539 0 0 0 0 0 8.39403 0 0 0 0 0 A0A8I3NX78 A0A8I3NX78_CANLF Olfactory receptor OR4A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PSLDAPMYFFLGYL;VILYTLKAL 2 7.5 1.0043 -1.052 0 0 0 0 0 0 0 0 0 6.08319 0 0 0 9.2508 0 A0A8I3NX83 A0A8I3NX83_CANLF N-acetylaspartylglutamate synthase (EC 6.3.2.41) RIMKLA Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] ATP binding [GO:0005524]; metal ion binding [GO:0046872] AWRTGGSG;GGGGGGGA;GGGGGGGG;WGGGGGGG 4 3.8 0.98985 -0.2654 0 0 11.8787 0 0 0 0 0 0 0 0 0 0 0 11.6598 A0A8I3NX84 A0A8I3NX84_CANLF "Testis expressed 264, ER-phagy receptor" TEX264 Canis lupus familiaris (Dog) (Canis familiaris) protein-DNA covalent cross-linking repair [GO:0106300]; reticulophagy [GO:0061709] autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; replication fork [GO:0005657] signaling receptor activity [GO:0038023] ELIQFYQKFGF;IGGLTLLLLLTLL 2 7.7 0.98416 -0.24188 0 0 0 5.09508 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NX86 A0A8I3NX86_CANLF "HLF transcription factor, PAR bZIP family member" HLF Canis lupus familiaris (Dog) (Canis familiaris) skeletal muscle cell differentiation [GO:0035914] nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAKRSRDARRLKEN;KYEARHGPL;LEYMDLEEFLSE;PADLALSSI;PANRNTPSPIDPDT 5 19.7 1.0017 -1.2492 0 0 9.95453 9.04023 0 0 10.5698 0 0 7.52144 8.30159 0 0 0 0 A0A8I3NX89 A0A8I3NX89_CANLF Protein YIPF IFT25 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] small GTPase binding [GO:0031267] TTIHIEGPSESPTH 1 4.6 0.93585 0.060936 0 8.0162 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NX91 A0A8I3NX91_CANLF Signal regulatory protein beta 2 SIRPB2 Canis lupus familiaris (Dog) (Canis familiaris) MTTPTHLAHCLPCSWL;QEDVKTPGPAKLGPH 2 9.1 0.9913 -0.19577 0 0 0 10.0623 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXB0 A0A8I3NXB0_CANLF Bromodomain-containing protein 2 BRD2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] AKSSSESSSEESSSES;DEEEDEEEEEEEEESESSD;EEDEEEEEEEEESES;EEEEEEEEESESSDSEEE;GPISKPKRKREKKEKKKKRKAEKHR;GRAGVDEDDKGSR;SSESSSEESSSESSSEEDEEED;SSSEEDEEEDEEEEE 8 10.6 0.56931 0.39662 0 0 6.07726 0 7.50962 0 0 8.29292 9.43727 0 3.4225 0 0 0 0 A0A8I3NXB7 A0A8I3NXB7_CANLF C2 calcium dependent domain containing 4C C2CD4C Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] ARRRLTRRA;GAAKANGG;KLQKQRSTIIKNSRH 3 6.8 1.0041 -1.1044 8.27519 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXC2 A0A8I3NXC2_CANLF CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) CNOT7 Canis lupus familiaris (Dog) (Canis familiaris) "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; defense response to virus [GO:0051607]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; P-body assembly [GO:0033962]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral genome replication [GO:0045070]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; regulatory ncRNA-mediated gene silencing [GO:0031047]" CCR4-NOT core complex [GO:0030015]; nuclear speck [GO:0016607]; P-body [GO:0000932] DNA-binding transcription factor binding [GO:0140297]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535]; transcription corepressor activity [GO:0003714] FFKMREMFF;GVVLCEGVKWLSFHSGYDFGYLIK;TNSNLPEEELDFFEILR 3 17.5 1.0013 -0.94736 0 0 0 6.21177 0 0 0 0 0 0 11.6227 11.349 11.8766 0 0 A0A8I3NXD1 A0A8I3NXD1_CANLF Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) EIF3A EIF3S10 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; translation reinitiation [GO:0002188]; viral translational termination-reinitiation [GO:0075525] "cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; multi-eIF complex [GO:0043614]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]" mRNA binding [GO:0003729]; translation initiation factor activity [GO:0003743] AKEREKERILQEHEQIKKKTVRER;DDDRGPRRGLDDDRG;EEEEQRRAEEQMLKEREERERAER;KPAHILQEKEE;LEELDPDFIMAKQVEQ;PRRIGDEDRGSWRHADDDRPPRRGL;WGPPRESRPSEEREWDR 7 9.8 0.98732 -0.23022 9.19527 0 6.12191 0 0 0 0 7.93428 0 7.87909 0 0 10.79 0 11.2319 A0A8I3NXD2 A0A8I3NXD2_CANLF G2/mitotic-specific cyclin-B1 LOC487020 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] LALKILDNGEW;RMETSGCAPAEEYL;VPGKVIAKKIPK 3 9.4 0.98981 -0.26354 0 0 0 0 0 0 0 0 0 0 0 0 0 14.2645 0 A0A8I3NXD4 A0A8I3NXD4_CANLF LRAT domain containing 2 LRATD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] CSVFYRDECIYQK 1 4.4 0.94256 0.059672 0 0 0 0 0 0 0 0 0 0 4.81962 0 0 0 0 A0A8I3NXD5 A0A8I3NXD5_CANLF Caspase activity and apoptosis inhibitor 1 CAAP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] ASSGSGST;SSVSGSLQQDTKY;STSGCGST;VDSTSAVRENKQPEGLE;VTGGGSAG 5 14.4 1.0027 -0.72933 0 8.29034 0 0 0 11.0077 0 0 0 10.6782 0 10.6257 9.39802 10.2428 0 A0A8I3NXE6 A0A8I3NXE6_CANLF 40S ribosomal protein S6 LOC106559872 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KIQRLVTPRVLQHKRRRKLLA;LVIVKKGEKHIPG;LVTPRVLQHKRRRKLLAKRMK;VLQHKRRRKLLAKRMKEAKEKRQ 4 16.2 0.99711 -0.10539 0 0 0 0 0 5.22728 6.14798 9.94373 0 0 0 0 9.60777 0 10.3447 A0A8I3NXE8 A0A8I3NXE8_CANLF "Keratin, type I cytoskeletal 19 (Cytokeratin-19) (Keratin-19)" KRT15 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] DLRRTLQGLEIELQ;ELTLSRAD;ELTLSRADLEMQIET;GDGLLVGSE;LGGGYGGG 5 9.3 0.94474 0.061125 0 3.39136 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXF5 A0A8I3NXF5_CANLF Zinc finger CCCH-type containing 7A ZC3H7A Canis lupus familiaris (Dog) (Canis familiaris) miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608] metal ion binding [GO:0046872]; miRNA binding [GO:0035198] IMPLTSILPLQVEE;LTTSLEDFC;SEERRKRQQ;VPGDGATK 4 4.1 1.0034 -1.6398 11.5374 0 0 0 0 0 0 0 10.4781 0 0 0 0 10.32 0 A0A8I3NXF6 A0A8I3NXF6_CANLF DNA 3'-5' helicase (EC 5.6.2.4) WRN Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; isomerase activity [GO:0016853] EYSAAARASAHARRAASWA;LEKEMIKSLENLNTGMA;MGTEQCCDNCRSRLDQCS;RNPPINSDINKIKLIRK;VGIMGTEQCC;YRRHSLFGTGKDQKESWWK 6 6.1 0.98746 -0.3706 0 7.07991 0 9.12789 0 0 7.47533 0 0 0 0 0 5.05176 5.81632 0 A0A8I3NXF9 A0A8I3NXF9_CANLF Kallikrein related peptidase 4 KLK4 Canis lupus familiaris (Dog) (Canis familiaris) amelogenesis [GO:0097186]; extracellular matrix disassembly [GO:0022617]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] QCGLPHVPG 1 3.9 1.0039 -0.80421 0 0 0 0 0 0 0 8.21096 0 0 0 0 0 0 0 A0A8I3NXG9 A0A8I3NXG9_CANLF Mammalian defensins domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCCGCCGGCCSVP;CCCGCCGGCCSVPVVCCCR;CCGCCGGCCSVP;CCGCGGCGGCSSGCGGCGSC;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSV;CCPCCCGCCGGCCSVPVVCCC;CCSSCCPCCC;CCSSCCPCCCGCCG;CCSSCCPCCCGCCGG;CCSSCCPCCCGCCGGC;CCSSCCPCCCGCCGGCCS;CCSSCCPCCCGCCGGCCSVP;CCSSCCPCCCGCCGGCCSVPV;CGCGGCGGCSSGCGGCGSCGG;CGCSSCGCGKGCCQQKCCQ;CGGCGGCGG;CGGCGGCGGCGGCGGCGG;CGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGSCT;CGSCGGCGGCGGC;CGSCGGCGGCGGCGGC;CGSCGGCGGCGGCGGCGG;CGSCGGCGGCGGCGGCGGC;CPCCCGCCGGCC;CPCCCGCCGGCCSVP;CPCCCGCCGGCCSVPVVCCCRRSCG;CRCYRVGCCSSCCPCCCGCCGGC;CSSCCPCCCGCCGGCCSV;CSSCCPCCCGCCGGCCSVP;CSSCCPCCCGCCGGCCSVPVVCCC;CTTCRCYRVGCCSSCCPCCCG;CYRVGCCSSCCPCCCGC;CYRVGCCSSCCPCCCGCC;CYRVGCCSSCCPCCCGCCG;CYRVGCCSSCCPCCCGCCGGCC;CYRVGCCSSCCPCCCGCCGGCCSV;GCCGCGGCGGCSSGCGGCGSC;GCCGCGGCGGCSSGCGGCGSCGG;GCCGGCCS;GCCSSCCPCCCGC;GCCSSCCPCCCGCCGGC;GCCSSCCPCCCGCCGGCC;GCCSSCCPCCCGCCGGCCSVP;GCGGCGGCGGCGGC;GCGGCGGCGGCGGCGGCGG;GCGGCGSCGGCGGCGG;GCGGCGSCGGCGGCGGCGG;GCSSGCGG;GCSSGCGGCGSCGGCGGCGG;GGCGGCGGC;GGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGCGG;GGCGGCGGCGGCGGCGGSCT;GGCGGCGGCGGCGGCGGSCTTC;GGCGGCSSGCGGCGSCGGCGGCGGC;GGCGSCGGCGGCGGCGGCGGCGGC;GGCSSGCGGCGSCGGCGGCGG;GSCTTCRCYRVGCCSSCCPCCCG;GSCTTCRCYRVGCCSSCCPCCCGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCG;MGCCGCGGCGGCSSGCGGCGSC;MGCCGCGGCGGCSSGCGGCGSCG;PCCCGCCGGCC;PCCCGCCGGCCSV;RCYRVGCCSSCCPCCCGCCGG;RVGCCSSCCPCCCGCCGGCC;RVGCCSSCCPCCCGCCGGCCS;RVGCCSSCCPCCCGCCGGCCSV;SCCPCCCGCC;SCCPCCCGCCGGCCSVPV;SCCPCCCGCCGGCCSVPVVCC;SCCPCCCGCCGGCCSVPVVCCC;SCGCGKGC;SCGGCGGCGGCGGC;SCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGGCGGSCT;SGCGGCGSCGGCGGCGGCG;SGCGGCGSCGGCGGCGGCGGC;SGCGGCGSCGGCGGCGGCGGCGG;SSCCPCCCGCC;SSCCPCCCGCCG;SSCCPCCCGCCGG;SSCCPCCCGCCGGC;SSCCPCCCGCCGGCCSV;SSCCPCCCGCCGGCCSVPVVCCC;SSGCGGCGSCGGCGGCG;SSGCGGCGSCGGCGGCGG;SSGCGGCGSCGGCGGCGGCGGCG;SSGCGGCGSCGGCGGCGGCGGCGGC;TCRCYRVGCCSSCCPCCCGCCG;VGCCSSCC;VGCCSSCCPC;VGCCSSCCPCC;VGCCSSCCPCCC;VGCCSSCCPCCCGC;VGCCSSCCPCCCGCC;VGCCSSCCPCCCGCCGG;VGCCSSCCPCCCGCCGGC;VGCCSSCCPCCCGCCGGCCSV;VGCCSSCCPCCCGCCGGCCSVP;VGCCSSCCPCCCGCCGGCCSVPV;VGCCSSCCPCCCGCCGGCCSVPVV;YRVGCCSSCCPCCCGCC;YRVGCCSSCCPCCCGCCGGCCS;YRVGCCSSCCPCCCGCCGGCCSVP 114 90.1 0.97824 0.035538 8.57766 0 0 0 0 0 7.94292 0 0 0 0 0 0 0 0 A0A8I3NXH3 A0A8I3NXH3_CANLF RAD54 like 2 RAD54L2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658] AASGSQGPSLDSTSNGRHSAS;AGENSLFMGSTPSYY;SEEDEEEEKG;SMGLGKTLQVIS 4 4.1 1.0037 -0.82352 10.0677 0 0 0 3.57821 0 0 0 0 0 0 0 0 0 0 A0A8I3NXH4 A0A8I3NXH4_CANLF NSFL1 cofactor p47 (p97 cofactor p47) NSFL1C Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730] lipid binding [GO:0008289]; ubiquitin binding [GO:0043130] DEEEEEEEGQRSRFYAGGSE 1 5.4 0.96414 0.048688 7.09677 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXH5 A0A8I3NXH5_CANLF Cordon-bleu WH2 repeat protein like 1 COBLL1 Canis lupus familiaris (Dog) (Canis familiaris) actin monomer binding [GO:0003785] GNNSAHNE;GVAENNNV;LSKGNNSAH;NQLSEEKTKTQDAAIQ;PEASLGPGLPSHEQ;PSVDSFDG;RSKKKREQ;SLEILKNWESE;SLSKGNNSAHNEQ;VEKVILKPKILDKKKPTPIIP;VLPGDIIKSTTVHGS;VPSVESSPHVPHV 12 9.3 0.99676 -4.2163 0 0 0 6.04282 6.89057 4.95708 10.7635 9.72981 9.67483 8.82193 0 9.23829 8.15674 9.37245 8.37313 A0A8I3NXH6 A0A8I3NXH6_CANLF RRM domain-containing protein RBPMS Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DGRTFLKA;GGGGGGGE;GGGGGGGG;LLLLLLLL;LLLLLLLLL;LLLLLLLLLF;LTVPALYPSSPEV;NWEPSIKWTKHHSIHLF;RAPHLLLLLLLL;RPRPILSSFLPSF;SRAPHLLLLLLLLL;VWAPYPLYPAE 12 13.5 1.003 -0.781 8.08645 0 0 0 5.7264 0 0 0 7.97327 0 0 0 8.85278 0 11.2321 A0A8I3NXH8 A0A8I3NXH8_CANLF Pre-mRNA processing factor 8 PRPF8 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal tri-snRNP complex assembly [GO:0000244] catalytic step 2 spliceosome [GO:0071013]; U5 snRNP [GO:0005682] metallopeptidase activity [GO:0008237]; pre-mRNA intronic binding [GO:0097157]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070] ADILLFASYKW;EAVAVYTTTVH;EQIRDVPVLYHI;GMEISAPSQQRQQ;IIIRQPIRTEYKIA;QPVKVRVSYQKLLKYYVLNALKHR;TAKNNVVINYKDM;TDFKQYQVL;VGKGPGCG;WIKVEVQLKDLILA;YITAEEAVAVYTTTVHWLESRRFS;YKHDTKLLILAL 12 6.7 1.0027 -2.1211 0 13.3161 8.92006 7.21315 8.47367 8.03386 8.41523 11.6112 9.81189 0 11.4704 10.438 6.39946 11.4811 7.15684 A0A8I3NXI2 A0A8I3NXI2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DESVSELEEQDYT 1 16.5 0.94196 0.059864 0 0 0 0 0 0 0 8.66192 0 0 0 0 0 0 0 A0A8I3NXI5 A0A8I3NXI5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FCSCYGAI 1 9.4 1.0041 -1.1044 0 0 8.61121 0 0 0 0 0 0 0 4.15462 0 0 0 0 A0A8I3NXJ0 A0A8I3NXJ0_CANLF small monomeric GTPase (EC 3.6.5.2) RAB18 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] autophagosome membrane [GO:0000421]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GGACGGYC;LDNWLNELET 2 11.2 0.98935 -0.53171 0 3.98941 0 8.95274 0 0 0 6.27469 0 0 0 0 0 0 0 A0A8I3NXL1 A0A8I3NXL1_CANLF XK-related protein XKRX Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATLKLKAVPFLLL;EDVIRGANPRFTFPFG;EEVLIEWEV;TLEITSRLVILVLFSATLKLKAV;VLYAGINF 5 13.6 1.0009 -0.6261 8.50371 9.24596 0 0 0 0 0 0 0 0 5.08653 0 0 0 0 A0A8I3NXM3 A0A8I3NXM3_CANLF Solute carrier family 35 member E2B SLC35E2B Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835] membrane [GO:0016020] SDLGVWSSRALLYLTLWFFFSF 1 5.4 0.97424 0.046925 0 0 0 0 0 0 0 6.84449 0 0 0 0 0 0 0 A0A8I3NXN1 A0A8I3NXN1_CANLF "TATA-box binding protein associated factor, RNA polymerase I subunit C" LOC119871931 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase I [GO:0006360] GPLPLLPPGPDPWDP;GVKMIDTKGP;SEPVLSLFQLS 3 4.4 0.98791 -0.22946 0 7.40463 0 0 0 0 0 0 0 0 0 0 0 0 9.14045 A0A8I3NXN4 A0A8I3NXN4_CANLF StAR-related lipid transfer protein 3 (START domain-containing protein 3) STARD3 Canis lupus familiaris (Dog) (Canis familiaris) late endosome membrane [GO:0031902] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] VILQPERMVLWNKTVTACQILQR 1 5.7 0.97543 0.046453 0 0 5.51712 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXP1 A0A8I3NXP1_CANLF CCAAT enhancer binding protein zeta CEBPZ Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] transcription coactivator activity [GO:0003713] AVEDPDEDDEEDNDEA;DIVLRRVKAFVKRLLQVT;DLEGSDDDLDNLDD;DPDEDDEEDNDEA;ESDEENFIDIGDDEDTEK;GAKEDPEDED;GASATWMKTI;GGKWYDLEYSNEYSLE;GTKQDYLMLATLDEN;IVSSGTLGDRMAAMILLIQ;KKKNFKKKRP;LKADIVLRRVKAFVKRLLQVT;LRRVKAFVKRLLQVT;NRDVKSIIKKKKNFKKKRPKTTQ;VKSIIKKKKNFKKKRPK;VKSIIKKKKNFKKKRPKTTQKIKKQ;WCGEEAVEDPDEDDEEDNDEAEDGF 17 16.5 1.0031 -1.7388 7.79636 13.6433 0 0 5.73679 4.83638 10.3439 9.47222 11.066 10.5147 6.27599 6.60263 6.69585 11.3116 8.16224 A0A8I3NXQ4 A0A8I3NXQ4_CANLF Olfactory receptor OR51H1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPGMPDKNAWMAF 1 4.1 0.98212 -0.25108 8.79507 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXQ5 A0A8I3NXQ5_CANLF Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] catalytic activity [GO:0003824] CDFKLMTTDIPSWGSAT;VEEVLRSSD 2 8.9 0.99368 -0.15971 0 0 0 0 0 0 0 0 0 10.5939 0 0 0 0 0 A0A8I3NXR6 A0A8I3NXR6_CANLF V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] clathrin-coated vesicle membrane [GO:0030665]; proton-transporting V-type ATPase complex [GO:0033176] "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" LKKIQKKKKIL;NFYRLKKIQKKKKILQ;RLKKIQKKKKIL 3 11.9 0.86634 0.13516 0 4.59914 0 3.99865 0 0 0 0 5.71998 0 0 0 4.64368 0 0 A0A8I3NXR8 A0A8I3NXR8_CANLF Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) DNTTIP1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730] DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803] GDAEQPRGPGGAERGG;VEKMRKYMETLRTENEHRAVEAPP 2 10.8 0.98771 -0.49486 0 10.0733 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXS2 A0A8I3NXS2_CANLF 60S ribosomal protein L6 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] organelle membrane [GO:0031090]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GEIFDTEKEKYEITEQRKVD;PRHRDGEIFDTE 2 8.7 0.9968 -0.11147 0 0 0 0 6.72165 0 0 9.93527 0 0 0 0 0 0 0 A0A8I3NXS7 A0A8I3NXS7_CANLF SH3 domain-containing YSC84-like protein 1 SH3YL1 Canis lupus familiaris (Dog) (Canis familiaris) EFTEITSRNGPDKIIPAH;LSQPIEVTALYSFEGQQ;TDSHFDWWE 3 13.6 1.0014 -0.70967 0 0 0 0 4.46316 0 6.18597 0 0 0 6.42836 0 0 0 0 A0A8I3NXS8 A0A8I3NXS8_CANLF "MGAT4 family, member F" MGAT4F Canis lupus familiaris (Dog) (Canis familiaris) LSDMMAAGSAPPQV;LVMGDRVRCSPEFI;PQVAYVLNKE;VLSFLLQENEEE 4 9.7 1.0004 -0.93085 0 11.2586 0 0 0 0 0 0 0 11.588 0 0 8.96457 0 0 A0A8I3NXT2 A0A8I3NXT2_CANLF Chimerin 1 CHN1 Canis lupus familiaris (Dog) (Canis familiaris) ephrin receptor signaling pathway [GO:0048013] ephrin receptor binding [GO:0046875]; GTPase activator activity [GO:0005096] THNFLWPRAPACSVL;WGRSGPAARGGRARRRR 2 11 0.99073 -0.19536 6.54597 6.48832 0 0 0 0 0 6.92754 0 0 0 0 9.16347 0 0 A0A8I3NXU2 A0A8I3NXU2_CANLF Ras-related protein Rab-14 (EC 3.6.5.2) RAB14 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; Golgi to endosome transport [GO:0006895]; phagosome maturation [GO:0090382]; protein transport [GO:0015031] cytosol [GO:0005829]; early endosome membrane [GO:0031901]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVGKSCLLHQFT;RRARPAPPRPAP 2 4.3 0.98786 -0.26024 0 0 0 6.2307 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NXV7 A0A8I3NXV7_CANLF DNA-directed RNA polymerase subunit POLR3H Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] RNA polymerase III complex [GO:0005666] FDDILIPPESLQ;VDTSPTGP 2 11.4 1.0039 -1.0539 0 0 0 8.88899 0 0 0 0 0 0 0 0 4.44784 0 0 A0A8I3NXW8 A0A8I3NXW8_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF14 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; protein K6-linked ubiquitination [GO:0085020]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of canonical Wnt signaling pathway [GO:0060828]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosolic ribosome [GO:0022626]; nucleoplasm [GO:0005654] nuclear androgen receptor binding [GO:0050681]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ECMYFLECRHVYCK;LNCPEPKCPSV 2 5.3 0.92771 0.09626 0 0 0 0 0 0 0 0 0 0 0 0 8.96099 8.84555 0 A0A8I3NXY4 A0A8I3NXY4_CANLF Interleukin 5 receptor subunit alpha IL5RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] CWFPRTFISSRGSDSLAVQVKG;DKKSLLLPPTNF;HWEPNPDQEPNNV;LFALHEIGNDDQK 4 18.5 0.99382 -0.04418 0 0 8.86586 7.62578 0 9.74108 0 0 0 0 0 10.6305 8.40199 0 0 A0A8I3NXZ6 A0A8I3NXZ6_CANLF Nucleoporin NSP1-like C-terminal domain-containing protein NUP62CL Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] DPLQQICKILNAHMD;VKLDQQRLEQELDF 2 11.8 0.98958 -0.20227 0 0 0 0 0 0 0 0 11.0148 0 0 0 0 9.05848 0 A0A8I3NY01 A0A8I3NY01_CANLF DEAF1 transcription factor DEAF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] ASCTCAACCDDMTLSGP;CTCAACCD;LSRDEDSEEDGDS;NPHAASCTCAACCDDMT;RFPTAACRCSTERVL;SCTCAACCDDMT;TLFKSRLG;VLSRDEDSEEDG 8 9.7 0.95233 0.053886 0 0 0 4.9698 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NY05 A0A8I3NY05_CANLF CCDC92/74 N-terminal domain-containing protein CCDC92B Canis lupus familiaris (Dog) (Canis familiaris) AAGGGGGG;AANRELESKCR;AGGGGGGGGREGRPGVPPG;GGGGGGGG;RERGTEEREERRG 5 10.9 0.99377 -0.14303 0 0 0 0 13.2311 0 0 0 6.94087 0 0 7.88832 0 0 0 A0A8I3NY06 A0A8I3NY06_CANLF Polypyrimidine tract-binding protein 1 PTBP1 Canis lupus familiaris (Dog) (Canis familiaris) "IRES-dependent viral translational initiation [GO:0075522]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleus [GO:0005634] mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002] IIVENLFYP;SQPSLDQTMAAAFGLSVPNVHGAL 2 6.2 0.9928 -0.19382 0 0 0 0 0 0 0 0 7.84536 0 0 0 9.53798 0 0 A0A8I3NY16 A0A8I3NY16_CANLF TLC domain containing 2 TLCD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane assembly [GO:0071709]; phospholipid homeostasis [GO:0055091]; plasma membrane organization [GO:0007009]; regulation of membrane lipid distribution [GO:0097035] plasma membrane [GO:0005886] CHHLVVVSCL;TPGSAAQDRWKWRN 2 9.1 1.001 -0.92387 5.04653 5.34067 0 0 0 0 0 0 0 0 0 5.1863 5.2317 0 10.6388 A0A8I3NY18 A0A8I3NY18_CANLF MyoD family inhibitor MDFI Canis lupus familiaris (Dog) (Canis familiaris) ATCGSCSSEDSCLCCC;ATCGSCSSEDSCLCCCCCGS;ATCGSCSSEDSCLCCCCCGSGEC;ATCGSCSSEDSCLCCCCCGSGECAD;CATCGSCSSEDSCLCCCCCGS;CATCGSCSSEDSCLCCCCCGSGE;CCCCCGSG;CCCCCGSGECAD;CCCCCGSGECADCDLPCDLDCGIV;CCCCGSGECADC;CCCCGSGECADCD;CCCCGSGECADCDLP;CCCCGSGECADCDLPC;CCCCGSGECADCDLPCD;CCCCGSGECADCDLPCDLDCGIV;CCGSGECADCDLPCDLDC;CGSCSSEDSCLCCCCCG;CGSCSSEDSCLCCCCCGSG;CGSCSSEDSCLCCCCCGSGEC;CGSCSSEDSCLCCCCCGSGECADC;CLCCCCCGSGECADC;CLCCCCCGSGECADCDLPCD;CLCCCCCGSGECADCDLPCDLDCG;CMECCGLCFS;CSSEDSCLCCCCCG;CSSEDSCLCCCCCGSGE;CSSEDSCLCCCCCGSGEC;CSSEDSCLCCCCCGSGECA;CSSEDSCLCCCCCGSGECAD;CSSEDSCLCCCCCGSGECADC;DCATCGSCSSEDSCLCCCCCGSG;DSCLCCCCCGSGEC;DSCLCCCCCGSGECADCD;DSCLCCCCCGSGECADCDLPCD;EDSCLCCCCCG;EDSCLCCCCCGSGECAD;EDSCLCCCCCGSGECADC;EDSCLCCCCCGSGECADCD;GSCSSEDSCLCCCCCG;GSCSSEDSCLCCCCCGSGE;GSCSSEDSCLCCCCCGSGEC;GSCSSEDSCLCCCCCGSGECAD;IVLDCATCGSCSSEDSCLCCCCC;IVLDCATCGSCSSEDSCLCCCCCGS;LCCCCCGS;LCCCCCGSGECADCDLPCD;LDCATCGSCSSEDSCLC;LDCATCGSCSSEDSCLCCCCCGS;SCLCCCCCGSGECADCDLPC;SCLCCCCCGSGECADCDLPCD;SCLCCCCCGSGECADCDLPCDLD;SCSSEDSC;SCSSEDSCLC;SCSSEDSCLCCCCC;SCSSEDSCLCCCCCGS;SCSSEDSCLCCCCCGSGEC;SEDSCLCCCCC;SEDSCLCCCCCGSG;SEDSCLCCCCCGSGEC;SEDSCLCCCCCGSGECADC;SEDSCLCCCCCGSGECADCDL;SEDSCLCCCCCGSGECADCDLPC;SSEDSCLCCCCCGSGECA;SSEDSCLCCCCCGSGECADC;SSEDSCLCCCCCGSGECADCD;SSEDSCLCCCCCGSGECADCDL;TCGSCSSEDSCLCCCC;TCGSCSSEDSCLCCCCCGS;TCGSCSSEDSCLCCCCCGSGE;TCGSCSSEDSCLCCCCCGSGEC;TCGSCSSEDSCLCCCCCGSGECAD;VLDCATCGSCSSEDSCLCCCCCGS 72 28.1 1.0036 -1.0542 10.0326 9.60966 9.64681 10.5632 8.82251 8.80445 10.2268 12.5439 9.20643 10.6185 10.0522 8.46695 9.96084 9.20011 12.2366 A0A8I3NY28 A0A8I3NY28_CANLF Cyclin dependent kinase 13 CDK13 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription elongation by RNA polymerase II [GO:0032968] cyclin/CDK positive transcription elongation factor complex [GO:0008024] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] EDKDTDSLRGN;GAGASQTN;GVLPSSQLKP;KVITLWYR;PKKQYRRKLREE;PSQPQQDGGGGASSGG;RSRTKSSK;TDPHAGVKAAL 8 6.2 0.99756 -3.7508 8.35874 10.3748 8.60541 0 9.23597 0 0 10.8445 0 9.6804 0 8.24208 0 5.43219 0 A0A8I3NY31 A0A8I3NY31_CANLF nucleoside-diphosphate kinase (EC 2.7.4.6) Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] nucleoside diphosphate kinase activity [GO:0004550] HYIDLKDCPFFAGL 1 17.1 0.9397 0.060962 0 0 10.2704 0 0 9.03474 0 0 0 0 0 0 0 0 0 A0A8I3NY33 A0A8I3NY33_CANLF Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) AHCY Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] adenosylhomocysteinase activity [GO:0004013] RLKNGRRIILLAEGRLVN 1 4.2 0.97315 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 8.54632 0 0 A0A8I3NY51 A0A8I3NY51_CANLF BTB domain containing 8 BTBD8 Canis lupus familiaris (Dog) (Canis familiaris) DETEDERSEAENVG;ETHVTDMDFEDDQHFA;KSKIHVEEQKIPRHLSDDSG;LDKSIKHELESKQ;QQRTKNASSNLAKTQGESPNSV;SNPVCDLDSANP;SQRPLKSETCV;SVSDREKQGEEQDTNKK;VIEAFEQKME;YDSNLRIEVKMKKQSSNDLFQVN 10 12.7 1.0014 -0.70416 10.6612 11.1051 0 7.85941 9.72161 11.3598 8.18254 0 9.81686 0 0 0 9.8996 0 9.30554 A0A8I3NY54 A0A8I3NY54_CANLF Sterile alpha motif domain containing 12 SAMD12 Canis lupus familiaris (Dog) (Canis familiaris) TFTTMTKGSQGETI 1 7.1 0.94225 0.061073 0 8.7443 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NY55 A0A8I3NY55_CANLF bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) ENPP4 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; positive regulation of blood coagulation [GO:0030194]; purine ribonucleoside catabolic process [GO:0046130] plasma membrane [GO:0005886] bis(5'-adenosyl)-triphosphatase activity [GO:0047710] EIPARFHYQHNDRIQ;KDPFWWNEAEPIW 2 6.2 0.9895 -0.53109 0 0 0 0 9.39079 0 0 0 0 0 0 0 0 0 0 A0A8I3NY56 A0A8I3NY56_CANLF Cytochrome c oxidase assembly factor 5 COA5 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617] mitochondrion [GO:0005739] SFFECKRSMLDARARFRG 1 24.3 0.97295 0.048313 10.1674 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NY59 A0A8I3NY59_CANLF Creatine kinase B-type (EC 2.7.3.2) (Creatine kinase B chain) LOC100686502 Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] VISMQKGGNMKEVFTRFCNGLTQV 1 7.7 0.9919 -0.27809 0 0 0 0 11.811 0 0 0 0 0 0 0 0 0 0 A0A8I3NY67 A0A8I3NY67_CANLF Chloride intracellular channel protein Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254] NSNPALNDNL;NTAGLNIFAKFSAY;QKLCPGGQL 3 16.1 1.0042 -1.0523 0 8.67129 0 0 8.79886 0 0 0 0 0 0 0 0 0 0 A0A8I3NY88 A0A8I3NY88_CANLF Solute carrier family 19 member 3 SLC19A3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] vitamin transmembrane transporter activity [GO:0090482] QDGEEIPTSEIPTISGNLD;QKPSNKNTVSDEPSK 2 7.6 0.93837 0.10387 0 0 0 0 0 0 12.1826 0 0 0 0 0 7.05192 0 0 A0A8I3NY90 A0A8I3NY90_CANLF Chromosome 1 open reading frame 50 C15H1orf50 Canis lupus familiaris (Dog) (Canis familiaris) GGAAAALV;WTPYEDIEKH 2 8.1 1.0022 -1.4231 0 0 0 0 0 0 0 0 0 0 4.6084 5.52735 17.7356 0 17.8147 A0A8I3NY94 A0A8I3NY94_CANLF Follistatin like 3 FSTL3 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of transcription by RNA polymerase II [GO:0045944] extracellular space [GO:0005615]; nucleoplasm [GO:0005654] activin binding [GO:0048185]; fibronectin binding [GO:0001968] CVVCRAAPC;HPDLRVMYPGRCRKSC;PGGVCWLQQGREATCSLVL 3 16.7 1.0029 -1.0057 0 0 0 0 0 7.43513 0 0 0 0 9.11437 0 0 10.1841 0 A0A8I3NYA3 A0A8I3NYA3_CANLF Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 PAG1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868] membrane raft [GO:0045121]; plasma membrane [GO:0005886] SH2 domain binding [GO:0042169] PAARPGEEPEPDYE 1 3.2 0.93413 0.060769 0 0 0 0 0 0 0 0 0 6.49004 0 0 0 0 0 A0A8I3NYB6 A0A8I3NYB6_CANLF Olfactory receptor OR4K2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVKTAMRKLKNRLLNP 1 5.1 0.96301 0.049233 0 0 0 0 0 5.61906 0 0 0 0 0 0 0 0 0 A0A8I3NYB8 A0A8I3NYB8_CANLF Serine/threonine-protein kinase (EC 2.7.11.13) PRKD3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] VPHTFAVHSYTRPTICQ 1 1.9 0.98495 0.046227 0 0 0 0 0 0 0 0 0 7.75742 0 0 0 0 0 A0A8I3NYC5 A0A8I3NYC5_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" SMARCD1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SWI/SNF complex [GO:0016514] transcription coregulator activity [GO:0003712] DLYGPDNHLVEWHRTATTQ;QEALKRPIKQKRKLRIF;THKLQDPHEREFVICDKYLQ;TLDNKTMT 4 13.5 1.0015 -0.95268 0 0 0 10.8235 0 6.89458 0 0 0 7.3097 0 0 0 0 4.67423 A0A8I3NYD1 A0A8I3NYD1_CANLF Ephrin A2 EFNA2 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; bone remodeling [GO:0046849]; ephrin receptor signaling pathway [GO:0048013]; osteoclast differentiation [GO:0030316] plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875] LLLLLLPL;PAQRPLLPLLLLLLPLP 2 7.9 0.97727 0.046227 0 0 8.7444 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NYD7 A0A8I3NYD7_CANLF Calmodulin like 6 CALML6 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AGEPLNEVEAEQM;GVFEMFDEEGNGEV 2 17.3 0.98543 -0.43904 12.169 0 0 0 9.20141 0 0 0 0 0 0 0 0 0 0 A0A8I3NYE1 A0A8I3NYE1_CANLF Cathepsin W CTSW Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] QGNCRCCW 1 2.2 0.98943 -0.26527 0 0 0 0 8.28267 0 0 0 0 0 0 0 0 0 0 A0A8I3NYE6 A0A8I3NYE6_CANLF Tigger transposable element derived 2 TIGD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EFCGNFQEFVE;KMFWKNLTVLDAIYEVSRAWNMV;MLGKRKRVVLTIKDKL;VLRRLRTIIRRKQKIQN 4 12.8 0.86898 0.17723 0 0 6.83251 0 0 5.10999 7.4776 0 0 0 0 0 5.75481 0 0 A0A8I3NYF1 A0A8I3NYF1_CANLF Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) PMPCB Canis lupus familiaris (Dog) (Canis familiaris) protein processing involved in protein targeting to mitochondrion [GO:0006627] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] VVFDYLHATAY 1 2.1 0.9816 0.035491 0 0 8.45051 0 0 7.42139 0 0 0 0 0 0 0 0 0 A0A8I3NYF9 A0A8I3NYF9_CANLF Eosinophil peroxidase EPX Canis lupus familiaris (Dog) (Canis familiaris) defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] heme binding [GO:0020037]; peroxidase activity [GO:0004601] GVFTKRQRKALR;GVFTKRQRKALRQIS;NDPRIRNQRDCI;NQPLARWLAA 4 5.1 0.98484 -0.44482 0 0 0 0 0 12.3381 0 4.1631 0 0 0 0 8.39038 0 0 A0A8I3NYG2 A0A8I3NYG2_CANLF Homeobox D3 HOXD3 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; cell-matrix adhesion [GO:0007160]; DNA-templated transcription [GO:0006351]; embryonic skeletal system morphogenesis [GO:0048704]; glossopharyngeal nerve morphogenesis [GO:0021615]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; thyroid gland development [GO:0030878] aggresome [GO:0016235]; nuclear body [GO:0016604] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" GGSQPPGL;GSPVYVGGNFVDSMAPASG;NSCATAGESCEDKS;PPSSPTNPGGGV 4 12.3 0.99745 -0.10469 0 0 7.39977 0 0 0 0 0 0 0 0 5.25784 10.3009 7.36527 10.4109 A0A8I3NYG3 A0A8I3NYG3_CANLF Importin 9 IPO9 Canis lupus familiaris (Dog) (Canis familiaris) proteasome localization [GO:0031144]; protein import into nucleus [GO:0006606] cytosol [GO:0005829]; nuclear envelope [GO:0005635] histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267] AEWNQDDSNDMWE;DDSNDMWEDQEEDE;DLQAYLTDF;DMWEDQEEDEEEE;EFGVHLAE;ENSKFKSTVKKALPELIYYI;IPLLVKILK;LVHTQLEPLLEFLCS;QDDSNDMWEDQEEDE;QDDSNDMWEDQEEDEEEEED;QEAEQTKNSGTEHWWKI;SNDMWEDQEEDEEEEE;WNQDDSNDMWEDQEEDE;YEEDYYEDDEEDDPDA;YYEDDEEDDPDALK 15 11.5 1.0033 -2.2743 8.72887 5.00504 7.14822 0 0 0 0 9.48101 0 6.68032 11.3548 8.11603 0 0 0 A0A8I3NYG6 A0A8I3NYG6_CANLF Leucine-rich repeat transmembrane neuronal protein 1 LRRTM1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; postsynaptic membrane [GO:0045211] TQRRKQKQKQTMHQMAAMS 1 3.6 0.95328 0.049538 0 0 8.77334 0 0 0 0 0 0 0 6.90857 0 0 8.48712 0 A0A8I3NYH8 A0A8I3NYH8_CANLF Transmembrane protein 104 TMEM104 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVCVYSFMCQHS;PAFLVYHCRK 2 4.4 0.99067 -0.53703 0 0 0 0 0 0 11.6885 0 0 0 10.3975 0 0 0 0 A0A8I3NYI3 A0A8I3NYI3_CANLF General transcription factor IIH subunit 1 GTF2H1 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; transcription initiation at RNA polymerase II promoter [GO:0006367] transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] nuclear thyroid hormone receptor binding [GO:0046966] AGDTTNFHFSNE;LLQQLLPKFKRKAN;VLSSSAASSTITTLSPG 3 7.8 0.9854 -0.44378 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.11348 A0A8I3NYI8 A0A8I3NYI8_CANLF Fibromodulin (Keratan sulfate proteoglycan fibromodulin) FMOD Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] GPAYAYGSPPPPE;QYDEDPLWWFHYLRSQQSSYYDPYD;TVVDVMNFSKLQV 3 13.6 0.98918 -0.21646 0 0 0 0 8.16697 0 7.3679 0 0 0 0 0 0 0 0 A0A8I3NYJ0 A0A8I3NYJ0_CANLF Platelet-derived growth factor (PDGF) family profile domain-containing protein PGF Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] membrane [GO:0016020] growth factor activity [GO:0008083] VPGAPPGG 1 1.9 1.0041 -1.1044 7.92255 0 8.02026 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NYJ1 A0A8I3NYJ1_CANLF Contactin associated protein 2 CNTNAP2 Canis lupus familiaris (Dog) (Canis familiaris) adult behavior [GO:0030534]; cell population proliferation [GO:0008283]; limbic system development [GO:0021761]; positive regulation of gap junction assembly [GO:1903598]; social behavior [GO:0035176]; striatum development [GO:0021756]; superior temporal gyrus development [GO:0071109]; thalamus development [GO:0021794]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625] axolemma [GO:0030673]; cell surface [GO:0009986]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; paranodal junction [GO:0033010]; voltage-gated potassium channel complex [GO:0008076] enzyme binding [GO:0019899] AFFEEGMWLRYNFQA;DPKYYCNC;GANCENGG;KAPTEGHTRLELYSQ;VIALKFKT;YYCNCDADYK;YYCNCDADYKQWRKDA 7 4.9 0.99741 -3.5538 0 0 0 0 0 0 0 9.716 0 10.1317 0 0 0 8.24693 0 A0A8I3NYJ2 A0A8I3NYJ2_CANLF Tigger transposable element derived 5 TIGD5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] LGGISPSPAVPEDGV;PLSPPEELQTP 2 4 0.99398 -0.07259 0 12.0894 0 0 0 10.1094 0 0 0 0 0 0 0 0 0 A0A8I3NYK2 A0A8I3NYK2_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD7 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction assembly [GO:0034333]; artery morphogenesis [GO:0048844]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of ossification [GO:0030279]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of chondrocyte hypertrophy [GO:1903043]; protein stabilization [GO:0050821]; protein-containing complex localization [GO:0031503]; regulation of cardiac muscle contraction [GO:0055117]; regulation of epithelial to mesenchymal transition [GO:0010717]; response to laminar fluid shear stress [GO:0034616]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular septum morphogenesis [GO:0060412] adherens junction [GO:0005912]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] activin receptor binding [GO:0070697]; beta-catenin binding [GO:0008013]; collagen binding [GO:0005518]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]; type I transforming growth factor beta receptor binding [GO:0034713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ESYGKINP;GAGGGGGG;GGGGGGGA;GGGGGGGG;KSQLVQKVRSKIGC;VHVSVWSWLGLSNSQ 6 11.1 0.99766 -0.60128 0 11.2414 0 0 0 0 0 11.7324 13.2973 0 9.74019 0 0 0 0 A0A8I3NYK3 A0A8I3NYK3_CANLF Fibroblast growth factor (FGF) FGF22 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] HTGFYVAMN 1 5.3 0.98434 -0.24269 0 5.83097 0 0 10.3682 0 0 5.53602 0 0 5.54995 5.16116 6.43986 0 0 A0A8I3NYK6 A0A8I3NYK6_CANLF FERM domain containing 4A FRMD4A Canis lupus familiaris (Dog) (Canis familiaris) establishment of epithelial cell polarity [GO:0090162] cytoskeleton [GO:0005856] EGGATPVV;IRSLPHWNSQSSMPST;KPKMWSESSLDEPYEKVKK;LDPGEEPPIV;QLENLYFREKKF;RKLELLVQPKLLAKEL;SNGSDPMDDCSSCT;TDETFYIESI;TSAALPQSQRSSTPSSEI 9 11.4 0.99964 -0.61146 0 0 0 0 0 0 8.46769 0 0 0 0 0 0 0 0 A0A8I3NYM0 A0A8I3NYM0_CANLF SEC14 like lipid binding 1 SEC14L1 Canis lupus familiaris (Dog) (Canis familiaris) choline transport [GO:0015871]; negative regulation of RIG-I signaling pathway [GO:0039536] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] protein sequestering activity [GO:0140311]; RIG-I binding [GO:0039552] DLRLWTETIYQSASV;ETLGRLLILRAP;FELIMAAYE;LDTWSPPQ 4 6.2 1.0034 -2.4111 0 0 0 0 0 8.24698 10.2473 0 0 8.60862 0 0 0 0 0 A0A8I3NYN4 A0A8I3NYN4_CANLF Dynein axonemal assembly factor 9 DNAAF9 Canis lupus familiaris (Dog) (Canis familiaris) KLPKKTEQIRLLS;PLDIEDSLYFVKT;QAFALEGIGGD;SIVTGLPGCHAS;VHLYCNPVNYRYL;WMVYRQIMDSS 6 6.2 1.0027 -0.71935 0 0 0 0 7.85574 0 9.36023 0 0 0 0 0 0 0 4.72623 A0A8I3NYP2 A0A8I3NYP2_CANLF Protein RER1 LOC609055 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] ILVMYFIML;LMEDSDDGPSL 2 12.4 0.99256 -0.28339 0 0 0 0 0 0 7.17473 0 0 0 0 0 0 0 0 A0A8I3NYQ0 A0A8I3NYQ0_CANLF Cullin 3 CUL3 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell migration [GO:0016477]; cellular response to amino acid stimulus [GO:0071230]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; fibroblast apoptotic process [GO:0044346]; gastrulation [GO:0007369]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; liver morphogenesis [GO:0072576]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon production [GO:0032480]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TORC1 signaling [GO:1904263]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; regulation protein catabolic process at postsynapse [GO:0140252]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]; trophectodermal cellular morphogenesis [GO:0001831]; Wnt signaling pathway [GO:0016055] centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polar microtubule [GO:0005827]; postsynapse [GO:0098794]; sperm flagellum [GO:0036126] cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; Notch binding [GO:0005112]; POZ domain binding [GO:0031208]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] ILMYMDRV;QEIQRKNNSGLSFE;QLKARFLPSPVVIKKRIEGLI 3 5.6 1.0017 -0.99546 0 7.70901 0 6.70888 0 0 0 0 0 0 0 0 0 0 9.07812 A0A8I3NYR6 A0A8I3NYR6_CANLF Chromosome 17 open reading frame 99 C17orf99 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] KVVKTGDPASFS 1 5 0.94873 0.05044 0 4.63778 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NYR8 A0A8I3NYR8_CANLF Cadherin-4 CDH4 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CPCDENGDCTTI;DYEGSGSTAGSVSSLNSS;EVPENQVEVVVANLTVMDRDQ;LLFVVWMKR;WNAFYRIISGDPS;YDEEGGGEEDQDYD 6 9.8 1.0019 -0.91042 8.63612 3.59634 0 0 7.74005 0 0 6.12445 0 0 0 0 0 6.64544 0 A0A8I3NYS2 A0A8I3NYS2_CANLF Coagulation factor XI KLKB1 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] CGQRERPGVYTNVVEY;PHQITCNRNVYVDLVMKGMNY;VHCHFFTYATIYTLIHPWCSIF 3 9.4 0.99531 -0.15392 9.74246 0 0 9.67504 0 0 0 0 0 0 0 0 0 9.49871 0 A0A8I3NYS5 A0A8I3NYS5_CANLF ADAM metallopeptidase domain 7 ADAM7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CAEGECCESCQ;ISILAVMLVLVIFGVGVVILLI;IVADNNVYRRNSSPLSK;PVKYSDEGQH 4 8 0.99324 -0.18711 0 13.1536 0 0 0 5.99041 0 0 2.98143 0 0 0 0 0 0 A0A8I3NYS8 A0A8I3NYS8_CANLF G protein-coupled receptor 155 GPR155 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; cellular response to cholesterol [GO:0071397]; cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; positive regulation of TORC1 signaling [GO:1904263]; transmembrane transport [GO:0055085] lysosomal membrane [GO:0005765] cholesterol binding [GO:0015485] CCSCSMGNGGLHCQST;ETSCCSCS;EVEIITSGMVISTF;FVGQILVFVL;GKIKKLKKSAFVVLILLI;GKIKKLKKSAFVVLILLITAKLL;HYHRDLCIRNI;KEKNFVGQILVFVLLYSSLYS;KVKIVGLGLLRVL;LFPALLECFGIV;LFPALLECFGIVL;LIWSLAILLLSK;LKKSAFVVLILLITAKLLVL;LLIIGLFANLSSC;RDEYLFYRFLQ;SCCSCSMG;SLAILLLSKK;SLIWSLAILLLSKKYKQL;SSCLWWLFNQE;VGKIKKLK;VGKIKKLKKSAFVVLILLI;VGKIKKLKKSAFVVLILLITAKLL;VLILLITAKLLVLPLL;VLLYSSLYSTYLW;VLNFSNVDWSF;VVLILLITAKLLVLPLL 26 21.3 0.99683 -6.2569 8.98262 0 4.91452 9.31879 0 7.6453 12.5981 11.4527 0 5.45039 5.33196 9.43719 11.1363 5.29528 5.73631 A0A8I3NYT0 A0A8I3NYT0_CANLF ABI family member 3 binding protein ABI3BP Canis lupus familiaris (Dog) (Canis familiaris) AELPTTLETH;AELPTTLETHQST;KRTWYKKFVGVQLCN;LKPKIPLI;PSTSKRRIRPKTPRTKP;RPFNSDSYSECKGKQYVKRTWYKKF;SELPESTL;TATYDVFSSPTPSDEP;VPPRRKPLP 9 8.7 0.99118 -0.5142 0 0 9.80202 0 0 0 0 0 0 0 0 9.711 0 0 0 A0A8I3NYT2 A0A8I3NYT2_CANLF Nuclear cap-binding protein subunit 3 NCBP3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340] DEKRQHTRPRPQGSN;EEEEEDQDMDAD;EEEEEDQDMDADD;EEEEEEDQDMD;EEEEEEEEDQDMDA;PEEPIEEEEEEEEEEDQDMDADD;SGLVNVPEEPIEE;YHSRRIQRDVIKKRALIG 8 10.3 0.99097 -0.13765 0 0 0 0 8.47464 0 0 5.28777 0 0 0 0 6.12823 5.8537 9.43413 A0A8I3NYU2 A0A8I3NYU2_CANLF Homeobox A10 HOXA10 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; male gonad development [GO:0008584]; proximal/distal pattern formation [GO:0009954]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; uterus development [GO:0060065] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EAGGGGSGAGGGGGGGYYA;GAGGGGGG;GGGGGGGG;GSTATAEL;LTCGGGGGG;SLGNSKGENAANWLTAK 6 13.3 1.0032 -2.0656 0 0 0 10.0201 0 0 0 10.4539 0 0 0 0 4.89951 0 0 A0A8I3NYU9 A0A8I3NYU9_CANLF INO80 complex subunit B INO80B Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382] Ino80 complex [GO:0031011]; nuclear body [GO:0016604]; nucleolus [GO:0005730] GVHKKKHKKHKKKHK;GVHKKKHKKHKKKHKKKH 2 5.1 0.98912 -0.26302 0 0 0 0 0 0 0 0 5.01185 0 0 0 0 4.61453 0 A0A8I3NYV0 A0A8I3NYV0_CANLF DENN domain containing 3 DENND3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DLWHLMVKEMWAGK;GKKLADDHKDPQYIQQALT;LDTYMFHAFL;LSTVPVELYPQ;LTVGHQKQIDP;PDDRVKNFEL;SKTRRRSFRKKRDKPKS 7 7 0.98614 -0.4266 0 10.6537 0 0 0 0 4.403 13.4323 0 0 10.8492 12.4653 0 11.1102 10.6627 A0A8I3NYV1 A0A8I3NYV1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] SIWKHHMLNAT 1 8.5 0.98497 -0.2414 0 0 0 0 0 0 0 12.1586 0 0 0 0 0 0 0 A0A8I3NYW5 A0A8I3NYW5_CANLF Serpin family I member 1 SERPINI1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] PYEGDEISMMLVLSRQ 1 3.9 0.95645 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 9.62275 0 A0A8I3NYX3 A0A8I3NYX3_CANLF Forkhead box F2 FOXF2 Canis lupus familiaris (Dog) (Canis familiaris) embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digestive tract development [GO:0048566]; establishment of planar polarity of embryonic epithelium [GO:0042249]; extracellular matrix organization [GO:0030198]; genitalia development [GO:0048806]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein polyubiquitination [GO:1902914]; roof of mouth development [GO:0060021] nuclear body [GO:0016604]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; TFIIB-class transcription factor binding [GO:0001093]" CPVPAGPG;GGGGGGGD;GGGGGGGG;LKQPPALPP;PGGGGGGG;PPAAALEAAPPP 6 9.2 0.94564 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 11.1695 0 0 A0A8I3NYY8 A0A8I3NYY8_CANLF Rerating islet-derived 3 alpha REG3A Canis lupus familiaris (Dog) (Canis familiaris) LSCLMVLSQVRGEDSQ 1 12.4 0.96432 0.049233 0 0 0 0 0 0 0 0 9.78792 0 0 0 0 0 0 A0A8I3NYZ5 A0A8I3NYZ5_CANLF Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton [GO:0045111]; mitochondrion [GO:0005739] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" GISKRTTGYWSHSIQ 1 4.5 0.99383 -0.07573 0 0 0 0 0 9.59425 0 0 0 0 0 0 0 0 0 A0A8I3NYZ7 A0A8I3NYZ7_CANLF Metal response element binding transcription factor 2 MTF2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] CVQCLQKPMLF;FMSGKEIK;IVKDDEGKEDYQFDE;LFGDRFYT;QVMKQTLPYSVADLEWDAGHKTN 5 12.8 1.0033 -2.3958 0 0 0 8.11134 5.74725 0 0 7.99027 0 8.91007 0 0 0 0 0 A0A8I3NZ01 A0A8I3NZ01_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] RNA binding [GO:0003723] EDGLPEKLAQRNPMYQ;GPGGPKGG;MRCQEELRRMEELHN;PGPGQGGPKPPI;PMGPGPGQ;VIVEPLEQLDDEDGLPE 6 9.8 0.93932 0.10312 0 0 0 0 0 0 8.63648 0 0 0 0 0 9.88038 0 0 A0A8I3NZ04 A0A8I3NZ04_CANLF LSM family member 14B LSM14B Canis lupus familiaris (Dog) (Canis familiaris) mRNA binding [GO:0003729] PLGCREGFFVAVASGVDFEG;TDRPAPPREE;VQSQGQVNDENRRPQRRRSGNRR 3 10.5 0.97369 0.048296 0 0 7.29829 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZ13 A0A8I3NZ13_CANLF Ras-related protein Rab-7a RAB7A Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; phagosome-lysosome fusion [GO:0090385] autophagosome membrane [GO:0000421]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; phagocytic vesicle membrane [GO:0030670] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DFLTKEVMVDDR;SRKKVLLKVIILGDSGVGK;TSRKKVLLKVIILG 3 35.2 0.99248 -0.19244 4.16011 0 0 0 0 0 0 0 0 0 0 0 0 0 3.12965 A0A8I3NZ37 A0A8I3NZ37_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MELK Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DWCGDSSSTGV;ELFDYIISQ;ESNGLESKSLTPVLCRAS;HYNVTTTRLVNPDQLLNEIMSILP;TYLLLLAKKARGKPVRLRLPSF 5 14.5 1.0024 -0.65751 0 0 9.79635 0 0 0 6.70349 0 0 10.7307 0 0 0 8.1353 0 A0A8I3NZ44 A0A8I3NZ44_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLPVFYYVVTPV;QELQIFPFVF 2 6.9 0.99102 -0.22146 0 0 10.9596 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZ45 A0A8I3NZ45_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RC3H2 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]" cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630] CYNEFDEN;LVNCQLVEEEGRVRAMR;QRGKLFQVQTEFQMQKTMF;VQTEFQMQKTM 4 9.2 0.98719 -0.38129 0 0 0 7.35112 0 0 0 0 0 0 0 2.7041 0 8.38344 0 A0A8I3NZ61 A0A8I3NZ61_CANLF Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8) TAF8 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription open complex formation [GO:0001112]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of fat cell differentiation [GO:0045598]; RNA polymerase II preinitiation complex assembly [GO:0051123] perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982] AYAKRSQRMV;LTEMLQSYISEI;NRPHPPHIPSHFPEFPD;YIKTPTYREPVSDYQ 4 17.4 1.0025 -0.76208 0 9.15672 0 8.75649 0 8.88062 0 8.20706 0 0 0 0 7.14027 0 0 A0A8I3NZ62 A0A8I3NZ62_CANLF Solute carrier family 15 member 5 SLC15A5 Canis lupus familiaris (Dog) (Canis familiaris) peptide transport [GO:0015833]; protein transport [GO:0015031] membrane [GO:0016020] symporter activity [GO:0015293] GVFINALKICCLHYCSLARD;HYCSLARDVTSW;IPSGYYVQTMNS;KEKSIRQPRYF;LGRNKLVYVCLCLHFLGSALLSVV;VGICLLLVEMCERFTF 6 15.1 0.99722 -0.087811 0 8.75318 0 0 0 0 0 0 0 0 9.16368 0 0 0 9.853 A0A8I3NZ64 A0A8I3NZ64_CANLF BAF chromatin remodeling complex subunit BCL7C BCL7C Canis lupus familiaris (Dog) (Canis familiaris) SWI/SNF complex [GO:0016514] AAQGDTEDSEGAPP 1 6.5 0.98538 -0.24601 0 0 10.8238 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZ66 A0A8I3NZ66_CANLF Uncharacterized protein LOC119863926 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FLYYLTPDGQRF;GDVCCWWV;LTLLRFRVL;LVHNFTDAVIQER;VGPWHAVIRIF;VIPKGVTCLISIF 6 12.4 1.0025 -1.4059 0 0 0 0 0 0 0 0 8.81951 0 0 0 0 0 0 A0A8I3NZ74 A0A8I3NZ74_CANLF DM domain-containing protein DMRTB1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] EQDMALGAQGPEPAAG;GCAMKADPAGLAD 2 5.4 0.98848 -0.30929 9.1199 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZ81 A0A8I3NZ81_CANLF Sodium channel protein SCN9A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] EEAEAIAI;EGQSKYMTDVLYWIN;ETMWDCMEVAGQAMCL;GVVSLVDGPSALMLP;IRLARIGRILRLIKGA;LMNVSQNV;NPPDWTKNVEYTFTGIYTFESLV;PFIYGDIPPGMVSEP;PLSEDDFEMFYE;QPIYEYNLYMYIYF;RVIRLARIGRILRLIKGAK;SFVYFTKQSL;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGIRTL;VIRLARIGRILRLIKGAKGIRTLL;VLRSFRLLRVFKLAKSWPTLN 17 9.4 1.002 -1.2338 0 0 7.67497 7.08012 0 8.81788 6.66448 11.1404 0 0 9.47565 0 0 0 11.1504 A0A8I3NZ84 A0A8I3NZ84_CANLF Leucine rich repeat transmembrane neuronal 4 LRRTM4 Canis lupus familiaris (Dog) (Canis familiaris) EIPHHVKPLPYYSYDPPG;EQFKGLRKLIILHLR;IPGTEQEYEHVSFHKIIA;TQPTLETPSPS 4 10.5 0.98649 -0.4279 0 0 0 0 5.23324 8.72373 0 0 0 0 0 4.55539 0 8.13576 0 A0A8I3NZ86 A0A8I3NZ86_CANLF Cell division cycle 20 CDC20 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; metaphase/anaphase transition of meiosis I [GO:1990949]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; regulation of meiotic nuclear division [GO:0040020] anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654] anaphase-promoting complex binding [GO:0010997]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027] KENQPEESHTPTKKE;LKGHTARVLSLTM;TLRLWRCFE 3 7.4 0.99472 -0.19053 0 0 0 4.38433 0 0 0 0 0 7.75094 0 0 0 0 0 A0A8I3NZ94 A0A8I3NZ94_CANLF Leucine zipper putative tumor suppressor 2 (Protein LAPSER1) LZTS2 LAPSER1 Canis lupus familiaris (Dog) (Canis familiaris) fibroblast proliferation [GO:0048144]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; nuclear export [GO:0051168]; primary ureteric bud growth [GO:0060682]; spindle midzone assembly [GO:0051255]; ureter morphogenesis [GO:0072197]; Wnt signaling pathway [GO:0016055] centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; vesicle [GO:0031982] DDFAQLLQERE;DIEDAREQRARN;PRAAGLSGSQGSLTQLF;RRRGEEQRDSFEGERLAWQAE 4 9.1 0.98801 -0.34811 0 0 0 0 0 0 10.9592 0 0 0 0 0 9.40652 0 0 A0A8I3NZ95 A0A8I3NZ95_CANLF Uncharacterized protein CEP15 Canis lupus familiaris (Dog) (Canis familiaris) QEIRLSKRHKEIISQRLM 1 14.1 0.97707 0.048313 10.8622 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZA1 A0A8I3NZA1_CANLF Zinc finger SWIM-type containing 3 ZSWIM3 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DGCSCSCSFQQ;LPFLWGKPEEGEGLP;PAQPMIEKDLDLAKKSLVEPS;PRGDTAGKSQKTVCLQ 4 9.1 0.87335 0.14233 0 0 0 0 0 0 13.5058 0 0 9.95907 0 7.84725 0 0 3.70199 A0A8I3NZA4 A0A8I3NZA4_CANLF Angiopoietin 4 ANGPT4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] extracellular space [GO:0005615]; membrane [GO:0016020] receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297] EAYAQYEHFQLGSEGQ;PGARGPHPHL 2 4.1 0.99243 -0.55393 0 0 0 0 0 0 0 11.7758 0 0 0 0 0 0 0 A0A8I3NZA7 A0A8I3NZA7_CANLF NIPA magnesium transporter 2 NIPA2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] magnesium ion transmembrane transporter activity [GO:0015095] DIFNTSIVTPI;GAGEVANFAAYAFAPAT;SILGSTVM;TVMVIHAPKEE 4 12.9 1.0023 -0.65926 0 4.12961 0 0 0 0 0 0 11.4827 0 0 10.6863 4.19219 8.37278 10.532 A0A8I3NZA8 A0A8I3NZA8_CANLF Secreted frizzled-related protein 3 (Frizzled-related protein 1) (FrzB-1) FRZB Canis lupus familiaris (Dog) (Canis familiaris) cochlea morphogenesis [GO:0090103]; convergent extension involved in organogenesis [GO:0060029]; epithelial cell development [GO:0002064]; hepatocyte differentiation [GO:0070365]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell development [GO:0010721]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hepatocyte differentiation [GO:0070367]; neural crest cell differentiation [GO:0014033]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; somite development [GO:0061053]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] Wnt-protein binding [GO:0017147] GRLLLLLRTGLLALAA;RGVCISPEAIV 2 8.3 0.9555 0.049233 0 0 0 0 0 0 5.26858 0 0 0 0 0 0 0 0 A0A8I3NZB1 A0A8I3NZB1_CANLF Secretion regulating guanine nucleotide exchange factor SERGEF Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein secretion [GO:0050709] cytosol [GO:0005829]; nucleoplasm [GO:0005654] ASGTVFQWGTGLAS;VIGGTCYSWGWNEHG;VLAGSDHSASLTDAGELYVWG;VLSCGSNSFGQL 4 13.5 1.0022 -0.69203 9.1455 8.73772 0 0 0 0 0 0 9.46138 0 0 0 0 0 11.9174 A0A8I3NZB3 A0A8I3NZB3_CANLF Uncharacterized protein LOC541584 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVFYSTAVFTFLTHRFGH;SQTSPDTFLLMGIPGLE 2 11.1 0.9424 0.10156 0 0 0 9.4838 0 7.37487 0 0 0 0 0 0 0 0 0 A0A8I3NZB7 A0A8I3NZB7_CANLF Orthodenticle homeobox 1 OTX1 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; diencephalon morphogenesis [GO:0048852]; inner ear morphogenesis [GO:0042472]; metencephalon development [GO:0022037]; midbrain development [GO:0030901] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AASYPMSYSQGGSYAQGYP;GVDCSSYLAPMHSH;PYGMNGLGLA 3 12.1 0.98669 -0.45682 0 0 12.3584 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZB8 A0A8I3NZB8_CANLF cytochrome-b5 reductase (EC 1.6.2.2) CYB5RL Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] YKPNQENSLEKLPW 1 5.7 0.93797 0.062581 0 0 0 0 0 0 0 0 0 0 0 0 7.60214 0 0 A0A8I3NZC1 A0A8I3NZC1_CANLF Zinc finger SWIM-type containing 1 ZSWIM1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] zinc ion binding [GO:0008270] EQLVEARIQHSLNAICTGPAA 1 4.6 0.94941 0.050089 0 11.0811 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZC3 A0A8I3NZC3_CANLF Interleukin IL15 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] GVISLESGSHPIKE;LVWASVDVCSCIS;SIHMDTTLY 3 26.7 1.0022 -0.66859 8.26045 0 0 7.56384 0 0 0 0 10.0443 0 7.76308 0 0 6.69335 0 A0A8I3NZD1 A0A8I3NZD1_CANLF Fibroblast growth factor (FGF) AFG2A Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; lung development [GO:0030324]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; wound healing [GO:0042060] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] SPGGAMAAGSIT 1 3.8 0.98454 -0.23794 0 0 0 9.44805 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZD3 A0A8I3NZD3_CANLF Rho guanine nucleotide exchange factor 5 ARHGEF5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] ATLRTTHAH;FLILPFQRITRLKLLLQNIL;ILPFQRITRLKLLLQNILKRTQP;LMCLLDAWGLE;LSGELEDTCYPMTGTPGP;LTSFSRRLRYNK 6 5.1 0.98069 0.048313 0 0 0 7.85056 0 0 0 0 0 0 0 0 0 0 0 A0A8I3NZE0 A0A8I3NZE0_CANLF Sedoheptulokinase SHPK Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] kinase activity [GO:0016301] KTDQEKKRKEKKRKEKKRKK 1 13.1 0.97221 0.048206 6.85699 0 0 0 0 0 0 0 0 0 0 0 0 7.80652 0 A0A8I3NZF5 A0A8I3NZF5_CANLF palmitoyl-CoA hydrolase (EC 3.1.2.2) ACOT8 Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637]; dicarboxylic acid catabolic process [GO:0043649]; negative regulation of CD4 production [GO:0045225]; peroxisome fission [GO:0016559] peroxisomal matrix [GO:0005782] long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815] LVQGRLWRRDGVLAVSCAQ 1 6 0.95118 0.053265 0 0 0 0 0 0 0 0 7.79422 0 0 0 0 0 0 A0A8I3NZG0 A0A8I3NZG0_CANLF RAD51 associated protein 2 RAD51AP2 Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex [GO:0032991] ESLIMAIFYFREN;HPKNDSSECVIHQFE;LIMAIFYFREN;QEGSHLGNIFESLI;STEALTIA;VRDFTNIYWSQ;WSQNRPDVKKQ 7 5.9 0.93825 0.071651 4.9691 0 8.33333 0 0 0 8.76782 8.94533 0 9.35779 0 0 9.67288 8.61853 0 A0A8I3NZH2 A0A8I3NZH2_CANLF ADP ribosylation factor like GTPase 8A ARL8A Canis lupus familiaris (Dog) (Canis familiaris) anterograde axonal transport [GO:0008089]; protein transport [GO:0015031] axon cytoplasm [GO:1904115]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DIGGQPRFRSMW;GARTREQKASIS;GGGGGGGA;GGGGGGGG;GGGGGGGGH;SGKTTFVNVIASGQFNEDMIPTV 6 18.9 0.85552 0.14733 10.1093 0 0 0 0 8.54925 0 0 0 0 0 0 0 0 0 A0A8I3NZH5 A0A8I3NZH5_CANLF Tissue factor pathway inhibitor TFPI2 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] ANVTRYYFNPRHRT;KKMTKLSLVNRRLK 2 11.9 0.98198 -0.25077 0 0 0 0 0 9.40996 0 0 0 0 0 8.32993 0 0 0 A0A8I3NZI2 A0A8I3NZI2_CANLF Transmembrane channel-like protein TMC6 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] FYQLIQEQSQWVAEEGL;GGGGGGSAL;GMGWRTWLASRVSGTSGCVFPPPR;GPFRTLDTM;LDTMYEAGKVWV 5 7 1.0015 -0.91752 0 0 0 6.11028 9.64317 0 12.7551 0 4.56474 0 5.70299 0 0 0 9.26411 A0A8I3NZI5 A0A8I3NZI5_CANLF Cytochrome P450 family 4 subfamily F member 22 CYP4F22 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" EHVSLMTLDS;PKGIICLVS 2 3.6 0.99646 -0.57998 0 0 0 0 0 0 0 9.59505 0 0 0 0 0 0 0 A0A8I3NZJ0 A0A8I3NZJ0_CANLF G2/mitotic-specific cyclin-B2 CCNB2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] DALLCKIEDIDQEDWE;DIYQYLRQLE 2 9.6 0.98427 -0.25498 0 0 0 0 0 0 0 0 0 0 0 0 8.28586 0 0 A0A8I3NZJ1 A0A8I3NZJ1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YQDDTGRNAVDAFG 1 15.9 0.9863 -0.25963 0 0 0 0 0 0 0 8.03309 0 0 0 0 0 0 0 A0A8I3NZK1 A0A8I3NZK1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] GQSKLKTFWRGFTIL;LFTTWFTEYFKPTVE;NSTSVLQPMDQGV;PSATTTLITQQ;VLQPMDQGVI;YFKPTVETYCSEKKIP 6 10.8 1.0043 -1.0768 9.31023 0 0 0 0 0 0 11.6379 0 0 8.16471 0 9.40846 0 0 A0A8I3NZK9 A0A8I3NZK9_CANLF Erlin (SPFH domain-containing protein) (Endoplasmic reticulum lipid raft-associated protein) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein) ERLIN1 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; ERAD pathway [GO:0036503]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; SREBP signaling pathway [GO:0032933] endoplasmic reticulum membrane [GO:0005789]; protein-containing complex [GO:0032991] cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625] ENLKQALQKDLNVM;GLTIQAVRVTKP;HIMLPFITTF;IELFDQIDEN;LFDQIDENLKQ;RKSSLLSKEALEPS 6 16.7 1.0021 -0.95959 0 0 0 0 0 0 13.5272 0 0 12.8987 12.2226 0 12.7786 9.57389 8.92264 A0A8I3NZL7 A0A8I3NZL7_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DERFEGGDPRRPQMP;EDGEREHEDEGE;SNQLHSYVNSI;TEEQYIFIHDALLE;VGLAPLPGMKGTDYI;VIDSMLQQIK;VTSTLLAGL 7 6.9 1.0038 -2.0345 0 10.7094 11.1323 0 0 0 0 8.87163 0 0 0 0 0 0 8.94956 A0A8I3NZL9 A0A8I3NZL9_CANLF Olfactory receptor OR2A58 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ICHPLQYTVIMNWRV 1 4.8 0.98887 -0.26232 0 0 0 0 0 10.1338 0 0 0 0 0 0 0 0 0 A0A8I3NZM8 A0A8I3NZM8_CANLF WAP four-disulfide core domain 8 WFDC8 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] DLHCQDYM;FCLSDLHC;SCNIGLSRWYFDFKHRICKPF 3 14.2 1.0022 -0.7678 0 9.70002 0 0 0 10.8657 0 0 0 0 0 0 0 0 0 A0A8I3NZN2 A0A8I3NZN2_CANLF TPD52 like 2 TPD52L2 Canis lupus familiaris (Dog) (Canis familiaris) QGRAGPGG 1 2.1 1.0034 -1.1044 0 0 0 0 12.2089 0 0 0 0 0 0 0 0 0 0 A0A8I3NZN6 A0A8I3NZN6_CANLF coproporphyrinogen oxidase (EC 1.3.3.3) CPOX Canis lupus familiaris (Dog) (Canis familiaris) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial intermembrane space [GO:0005758] coproporphyrinogen oxidase activity [GO:0004109]; protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212] AAFGRAERAE;GDDDDDDDELGRRCRCFMA;NSKEAEILEDRKEDR;VLQDGHVFEKAG 4 10.1 0.98672 -0.45924 0 5.95935 0 0 0 0 0 0 0 0 0 0 0 10.0996 0 A0A8I3NZN7 A0A8I3NZN7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NRK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AARVFMPLQAQV;DDDDSNDAYEDTYDHDNSNDDL;EVQIEPLQPYIPN;FIGTPYWMAPE;GADTDGDDDDS;GADTDGDDDDSNDAYEDTYDHD;LKRRSIKKLRF;QVPEQQQRQGQAPEQ;VSPACKKPLIHMYEKEFT;YNALSEIFRNDWLTP 10 8.1 0.93645 0.074291 7.40506 3.99367 0 10.2257 3.27349 5.35632 6.49318 0 0 0 0 5.68538 4.31383 0 0 A0A8I3NZP1 A0A8I3NZP1_CANLF USH1 protein network component sans USH1G Canis lupus familiaris (Dog) (Canis familiaris) equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; regulation of clathrin-dependent endocytosis [GO:2000369]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] actin cytoskeleton [GO:0015629]; Cajal body [GO:0015030]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917] identical protein binding [GO:0042802]; spectrin binding [GO:0030507] SISVPLGPRKKILGAVRR;WCLDNDYHTPLD;YLELLKEATRKELNAPDEDGM 3 11.2 0.85815 0.1466 0 4.22897 5.6459 0 0 0 0 0 0 0 0 0 5.91593 9.089 0 A0A8I3NZP5 A0A8I3NZP5_CANLF "Myosin light chain 1/3, skeletal muscle isoform (Myosin light chain alkali 1/2)" MYL1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] VGDVLRALGTNPTNAE 1 11.1 0.96127 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 10.156 0 A0A8I3NZP6 A0A8I3NZP6_CANLF Karyopherin subunit beta 1 KPNB1 Canis lupus familiaris (Dog) (Canis familiaris) astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; NLS-bearing protein import into nucleus [GO:0006607]; ribosomal protein import into nucleus [GO:0006610]; RNA import into nucleus [GO:0006404] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] Hsp90 protein binding [GO:0051879]; importin-alpha family protein binding [GO:0061676]; nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267] DDDDDWNPCKAAGVC;ESLMEIVKNSAKDCYPAVQ;HQNNLRSSAYESLMEIVKNS 3 5 0.99241 -0.16552 8.93981 0 0 0 0 0 9.7473 9.20804 0 0 12.2881 0 0 0 0 A0A8I3NZP7 A0A8I3NZP7_CANLF Euchromatic histone lysine methyltransferase 2 EHMT2 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; fertilization [GO:0009566]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; oocyte development [GO:0048599]; organ growth [GO:0035265]; phenotypic switching [GO:0036166]; regulation of DNA replication [GO:0006275]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130] chromatin [GO:0000785]; nuclear speck [GO:0016607] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K56 methyltransferase activity [GO:0140759]; histone H3K9 methyltransferase activity [GO:0046974]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] AGTFLECH;EEEEEEEEEEEEDEESGNQ;EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEEEEEE;HCCPGCGY;QPPVPEKRPPEVQHFRM;SEEEEEEEEEEEEEEEEEEEEEEEE;SLYYDSYSVDERVDSDSKSEVEA;VLCETHRAR;WAPQLPSGLTSP 10 8.9 0.95231 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 5.0914 0 0 A0A8I3NZQ0 A0A8I3NZQ0_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC119866314 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ENEGNKVQ;LASEVARDQAGPSI;QEENEGNEVTCGLIPR;VLIVRYQPERKN 4 7.6 0.99232 -0.0066631 0 0 0 0 0 0 0 0 3.45483 0 9.11842 0 0 0 8.9646 A0A8I3NZQ4 A0A8I3NZQ4_CANLF Zinc finger MYM-type containing 6 ZMYM6 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AASMTGRCSGLRA;EEFCCEDC;FCCEDCMS;HLAMSNGTI;ILSTENMKPA;ISRGRILTRLFELRHEVE;LSAYRVKT;LVKLKCQHCC;NADIRFEVKYQNVVHG;QELLDKIKEEPDN;QVVVNPPS;TMNCCENCGSYCYSSSGP 12 10.3 0.99717 -3.6304 8.87181 0 10.8341 9.35014 9.02076 8.14093 0 11.4871 10.9799 9.58581 7.88228 9.23668 0 8.6037 11.2015 A0A8I3NZR1 A0A8I3NZR1_CANLF "Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (Splicing factor, arginine/serine-rich 2)" SRSF2 Canis lupus familiaris (Dog) (Canis familiaris) "regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" cytosol [GO:0005829]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] pre-mRNA binding [GO:0036002] YTKESRGFAF 1 4.5 0.8626 0.17622 0 0 0 0 0 0 9.44913 9.49512 0 0 0 0 0 0 0 A0A8I3NZS0 A0A8I3NZS0_CANLF Small ubiquitin-related modifier 1 SUMO1 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; PML body [GO:0016605] protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389] TTEIPRLSFQRRA 1 4.9 0.98961 -0.19917 0 0 0 0 0 0 0 0 0 9.56537 0 0 0 0 0 A0A8I3NZT4 A0A8I3NZT4_CANLF Armadillo repeat containing X-linked 1 ARMCX1 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic stem cell homeostasis [GO:0061484] GVKTGKGA;LPIIAKLIKTK;LVVKVKVLKVLT;LVVKVKVLKVLTKL;PSELISLFNKEWD 5 10 0.98616 -0.45353 5.00004 0 8.06878 0 0 0 0 0 0 0 0 0 8.44079 6.50222 0 A0A8I3NZU3 A0A8I3NZU3_CANLF "Cystinosin, lysosomal cystine transporter" CTNS Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TQHVSWPAISFL;VTLIKYFPQA 2 6 0.98969 -0.22338 0 5.61265 0 0 0 0 0 0 9.07296 0 0 0 0 0 0 A0A8I3NZU6 A0A8I3NZU6_CANLF Leucine rich repeat containing 4B LRRC4B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of synapse assembly [GO:0051965] cerebellar mossy fiber [GO:0044300]; synaptic membrane [GO:0097060] signaling receptor binding [GO:0005102] AAGGGGPG;PGGGGGGG;TTVPTQAFEYLSKLRELWLR;VICTRRELAEVPASIPVNTR 4 7.8 0.93713 0.097287 8.77472 0 0 0 0 0 0 0 0 0 0 0 0 7.14354 0 A0A8I3NZV1 A0A8I3NZV1_CANLF Prostaglandin reductase 2 (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) PTGR2 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin metabolic process [GO:0006693] cytoplasm [GO:0005737] 15-oxoprostaglandin 13-oxidase activity [GO:0047522] ILDGNGLEKVDPQ;ISQYNKDVPYPPPL;TMVVSGAAGACGSL;VEEVNLPNNI;VISQMNRNSHVI 5 19 1.0011 -0.62409 0 0 0 0 0 0 0 0 10.0007 9.61708 0 0 0 9.19296 0 A0A8I3NZV2 A0A8I3NZV2_CANLF KLF transcription factor 14 KLF14 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of sphingolipid mediated signaling pathway [GO:1902070]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin binding [GO:0003682]; sequence-specific double-stranded DNA binding [GO:1990837] GALEVPGAPA 1 3.2 0.9951 -0.084229 0 12.1622 12.2556 0 0 0 0 0 12.5162 0 0 12.1381 0 0 0 A0A8I3NZW0 A0A8I3NZW0_CANLF Aladin WD repeat nucleoporin AAAS Canis lupus familiaris (Dog) (Canis familiaris) EAHSMVWDPSGE;EAHYGSSPLAML;GGVTNLLW;SSCDCPNCQE 4 5 1.003 -2.1254 0 0 8.97696 0 8.68825 6.3976 0 0 9.15954 9.8345 5.83935 0 0 0 0 A0A8I3NZW4 A0A8I3NZW4_CANLF "Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10)" SLC2A10 Canis lupus familiaris (Dog) (Canis familiaris) artery development [GO:0060840]; cell redox homeostasis [GO:0045454]; embryonic skeletal joint development [GO:0072498]; glucose import across plasma membrane [GO:0098708]; negative regulation of connective tissue growth factor production [GO:0032683]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; negative regulation of proteoglycan biosynthetic process [GO:1902729]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of gene expression [GO:0010628]; positive regulation of proteoglycan biosynthetic process [GO:1902730]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of extracellular matrix organization [GO:1903053]; skin development [GO:0043588] cytosol [GO:0005829]; endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300] PAPEHALLHWTALV;PGGWRHMFGWAAAPA;VLCYASTIFHSVGFR 3 8.1 0.98949 -0.30434 12.7975 0 0 0 0 0 0 0 0 0 11.3956 0 8.08353 0 0 A0A8I3NZW5 A0A8I3NZW5_CANLF CFAP20 domain containing CFAP20DC Canis lupus familiaris (Dog) (Canis familiaris) AGTSESQNSLA;LPRENKQILGLIQRFLVLQIYIPL;LYDPCLNCYFDPQ 3 5.8 0.97568 0.046212 0 0 0 0 0 0 0 0 0 9.31974 0 0 0 0 0 A0A8I3NZX0 A0A8I3NZX0_CANLF Acetylcholine receptor subunit alpha CHRNA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; neuron projection [GO:0043005]; postsynapse [GO:0098794] excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] IFTEDIDISDI;KRPSREKQDKKIFTED;YHFVMQRLPL 3 8.5 0.9862 -0.23221 0 0 0 10.5733 0 9.16855 0 0 0 0 0 0 0 0 0 A0A8I3NZX1 A0A8I3NZX1_CANLF Synaptotagmin 3 SYT3 Canis lupus familiaris (Dog) (Canis familiaris) calcium-ion regulated exocytosis [GO:0017156]; cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059] endosome [GO:0005768]; exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149] IGVCRVGPDAADP;LGVSLFVS;LTPQPDPG;PDPGSEERPPALPL;RRLKKRKTSIKKNT 5 9 1.0019 -1.2731 0 0 0 0 0 0 9.43667 0 0 0 0 7.56613 0 0 0 A0A8I3NZX3 A0A8I3NZX3_CANLF Arginine vasopressin AVP Canis lupus familiaris (Dog) (Canis familiaris) ERK1 and ERK2 cascade [GO:0070371]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein kinase C signaling [GO:0070528]; symbiont entry into host cell [GO:0046718]; vasoconstriction [GO:0042310] extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; neurohypophyseal hormone activity [GO:0005185]; protein kinase activity [GO:0004672]; V1A vasopressin receptor binding [GO:0031894] AGICCNDESCV;AGICCNDESCVTEPEC 2 9.6 0.9902 -0.20027 11.8807 0 0 0 0 11.3267 0 0 0 0 0 0 9.70248 0 0 A0A8I3NZX4 A0A8I3NZX4_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872] GGGGGGGE;GGGGGGGG;LVVRKVPPG 3 4.6 1.0039 -0.80421 0 0 0 0 0 0 0 0 0 0 6.88435 0 8.55294 8.75158 8.77485 A0A8I3NZY4 A0A8I3NZY4_CANLF X-ray repair cross complementing 6 XRCC6 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; telomere maintenance [GO:0000723] Ku70:Ku80 complex [GO:0043564] ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; telomeric DNA binding [GO:0042162] EDLLRKVRAKETRKRVL;GTEKDKNSVNFKNIYVL;IFLDLMHLKKRGGFDI;LGYFLYCLSDSVCTLI;SGWESYYKNEGDEEGEQED;TKAGDLRDTGIFLD 6 16 0.98966 -0.50947 0 11.8469 0 6.13496 0 0 0 7.07842 0 0 0 0 10.2587 9.32674 0 A0A8I3NZY7 A0A8I3NZY7_CANLF N-acetylated alpha-linked acidic dipeptidase like 2 NAALADL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HSPIRGNS;LGVKKGWRPHRT;MKNTTNQI;TYEDVKTLEGP 4 5.2 1.0034 -2.0998 0 0 9.2525 0 0 0 0 0 0 0 0 0 10.8325 9.14606 0 A0A8I3NZZ8 A0A8I3NZZ8_CANLF AE binding protein 2 AEBP2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of transcription by RNA polymerase II [GO:0000122] ESC/E(Z) complex [GO:0035098] metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] AGEDEDEEEDEEEEDESSSSGG;DESSSSGGGE;EDEDEEEDEEEEDESSSSGGGE;GAASSSSG;GGGGGGGG;PDVWVNESERHQLKT;SEPSPESASQAGEDEDEEEDEEE;SKAGMNKRRKLKNKRR;SSATSGGR;SSGGGEEESSAESLVGSS;VWVNESERHQLKTKVVHL 11 21.3 1.0028 -2.5073 0 7.38871 6.8431 0 8.69846 9.76726 10.0798 10.2837 0 0 0 0 11.0731 0 6.13486 A0A8I3P002 A0A8I3P002_CANLF Uncharacterized protein SNX16 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] KVESSTFEVDQ;TRPRESEEQNPDTVYVEDRP 2 9.8 0.94503 0.08421 0 0 0 0 0 0 2.90188 0 9.15 0 0 0 0 0 0 A0A8I3P013 A0A8I3P013_CANLF GLI family zinc finger 3 GLI3 Canis lupus familiaris (Dog) (Canis familiaris) alpha-beta T cell differentiation [GO:0046632]; anterior semicircular canal development [GO:0060873]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; axon guidance [GO:0007411]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye morphogenesis [GO:0048593]; cell differentiation involved in kidney development [GO:0061005]; chondrocyte differentiation [GO:0002062]; developmental growth [GO:0048589]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain radial glial cell differentiation [GO:0021861]; frontal suture morphogenesis [GO:0060364]; heart development [GO:0007507]; hindgut morphogenesis [GO:0007442]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; lambdoid suture morphogenesis [GO:0060366]; larynx morphogenesis [GO:0120223]; lateral ganglionic eminence cell proliferation [GO:0022018]; lateral semicircular canal development [GO:0060875]; layer formation in cerebral cortex [GO:0021819]; lung development [GO:0030324]; mammary gland specification [GO:0060594]; melanocyte differentiation [GO:0030318]; metanephros development [GO:0001656]; negative regulation of alpha-beta T cell differentiation [GO:0046639]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative thymic T cell selection [GO:0045060]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; optic nerve morphogenesis [GO:0021631]; osteoblast differentiation [GO:0001649]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein processing [GO:0016485]; proximal/distal pattern formation [GO:0009954]; regulation of bone development [GO:1903010]; roof of mouth development [GO:0060021]; sagittal suture morphogenesis [GO:0060367]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; stem cell proliferation [GO:0072089]; thymocyte apoptotic process [GO:0070242]; tongue development [GO:0043586]; vocalization behavior [GO:0071625] axoneme [GO:0005930]; GLI-SUFU complex [GO:1990788]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; transcription repressor complex [GO:0017053] beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; mediator complex binding [GO:0036033]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AENSELLSPG;GGCAAAAK;GGRGSGSL;LVVHMRRHTGEKPHKCT;PIMDSTISTATT;PYMDYIRSLHSPSLS;SPSLSMISAARGLSPTDA;TPAQQYRLKAKY 8 5.9 1.0036 -2.0307 0 0 9.32973 7.35702 0 0 9.64153 10.8505 10.577 0 0 9.09162 0 0 0 A0A8I3P020 A0A8I3P020_CANLF "NACHT, LRR and PYD domains-containing protein 3" NLRP3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739] GVMLLCEVLKQ;HVEILGFSE;IVFEPFGSDRSRLPDASVWAPCHL;NSLEDAGVGVLCEKAKHPQC;NVLCEMLQ;PVALEKLQHLLDR;SDKIYQDRFDYLFYI;STLLTSSKS 8 10.2 1.0022 -1.017 0 0 10.557 0 11.2641 0 0 11.3146 0 0 6.04074 0 10.0228 0 0 A0A8I3P034 A0A8I3P034_CANLF Epidermal growth factor receptor pathway substrate 8 EPS8 Canis lupus familiaris (Dog) (Canis familiaris) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; cellular response to leukemia inhibitory factor [GO:1990830]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072] brush border [GO:0005903]; cell cortex [GO:0005938]; glutamatergic synapse [GO:0098978]; NMDA selective glutamate receptor complex [GO:0017146]; postsynaptic density [GO:0014069]; ruffle membrane [GO:0032587]; stereocilium tip [GO:0032426] actin binding [GO:0003779]; small GTPase binding [GO:0031267] LEEKEKRRKEGRKSQMEEVQDELI;LSKRKKSKKGKK;NKPDLHLFQCDEIKANLIS;PVTVNSLGVLNGAQL 4 7.3 0.98731 -0.50209 0 0 0 4.40953 0 0 8.90878 0 0 0 4.53835 0 0 0 5.72699 A0A8I3P037 A0A8I3P037_CANLF Ceramide synthase 5 CERS5 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] FWDIRQCWHSYPY;RIAFKALIRGKVTYPGRIRP;SDPYLAQPNAI;TSGLYYYYI 4 12 0.98619 -0.42322 0 10.3081 0 0 8.99752 0 0 0 0 0 0 0 0 9.21096 0 A0A8I3P040 A0A8I3P040_CANLF Armadillo repeat containing X-linked 3 ARMCX3 Canis lupus familiaris (Dog) (Canis familiaris) axonal transport of mitochondrion [GO:0019896]; mitochondrion organization [GO:0007005]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104] axon cytoplasm [GO:1904115]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] VGDCPGARYNDWSDDD 1 4.2 0.96173 0.049233 0 0 0 0 0 0 0 0 9.41363 0 0 0 0 0 0 A0A8I3P044 A0A8I3P044_CANLF Dynein assembly factor with WD repeats 1 DAW1 Canis lupus familiaris (Dog) (Canis familiaris) cerebrospinal fluid circulation [GO:0090660]; determination of left/right symmetry [GO:0007368]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158] extracellular region [GO:0005576] EELHTLEGHR;GVFSRSSSLESL 2 4.6 0.99463 -0.56109 0 0 0 0 0 0 0 0 0 0 0 0 9.95539 9.17722 0 A0A8I3P046 A0A8I3P046_CANLF E3 ubiquitin-protein ligase pellino homolog (EC 2.3.2.27) PELI2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; protein polyubiquitination [GO:0000209]; regulation of Toll signaling pathway [GO:0008592] ubiquitin protein ligase activity [GO:0061630] LWRTADGLFHTPTQ 1 3.3 0.94383 0.061116 0 0 0 0 8.79113 0 0 0 0 0 0 0 0 0 0 A0A8I3P056 A0A8I3P056_CANLF Large ribosomal subunit protein uL29m MRPL47 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] EEFFDDPKNWG;GAWRRDIFGRIIWHKFKQWPIPWYL;VGVLWRKVL 3 17.9 0.99076 -0.26858 9.47743 0 0 0 0 0 0 0 0 0 0 0 0 7.06856 0 A0A8I3P057 A0A8I3P057_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) DDX55 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] EINQKCPLQEMKL;FVIPILEILLRREEKLKKNQ;ILLRREEKLKKN 3 5.8 0.9899 -0.21516 0 0 0 11.6947 12.033 4.38426 0 0 0 10.1934 0 10.1343 0 11.3219 0 A0A8I3P059 A0A8I3P059_CANLF Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) BATF Canis lupus familiaris (Dog) (Canis familiaris) "defense response to protozoan [GO:0042832]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hematopoietic stem cell differentiation [GO:0060218]; isotype switching [GO:0045190]; lymphoid progenitor cell differentiation [GO:0002320]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of cytokine production [GO:0001819]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 2 cell differentiation [GO:0045064]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEMKYFTSVLSSHEPLCSVLAAST 1 19.2 0.97389 0.041303 0 0 0 0 0 0 0 0 8.13643 0 0 0 0 0 0 A0A8I3P081 A0A8I3P081_CANLF RANBP2-type and C3HC4-type zinc finger containing 1 RBCK1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of metabolic process [GO:0009893] metal ion binding [GO:0046872]; transferase activity [GO:0016740] DVAARQTTEMLRSMLQQGE;EQRVPLNVQLKPEV 2 6.6 0.98867 -0.26271 0 0 0 0 0 0 0 0 0 8.05772 0 0 0 0 0 A0A8I3P084 A0A8I3P084_CANLF ABI family member 3 binding protein ABI3BP Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; positive regulation of cardiocyte differentiation [GO:1905209]; positive regulation of cell-substrate adhesion [GO:0010811] interstitial matrix [GO:0005614] collagen binding [GO:0005518]; heparin binding [GO:0008201] AELPTTLAETHQS;KAPPSPEEPKTEVVESI;KHKTTPTT;KRTWYKKFVGVQLCN;LKPKIPLI;PSTSKRRIRPKTPRTKP;QTHRPRPRPKPTP;RPFNSDSYSECKGKQYVKRTWYKKF;SELPESTL;TATYDVFSSPTPSDEP;VPPRRKPLP 11 7.9 0.97672 0.046227 0 0 0 0 0 0 0 0 0 0 0 6.06837 0 0 0 A0A8I3P086 A0A8I3P086_CANLF Leiomodin 1 LMOD1 Canis lupus familiaris (Dog) (Canis familiaris) actin nucleation [GO:0045010]; pointed-end actin filament capping [GO:0051694]; positive regulation of actin filament polymerization [GO:0030838] cytosol [GO:0005829]; sarcomere [GO:0030017] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] DEPLERVKNNDPEMT;ERRRADPRTEDE;TTLLKLGYHFEL 3 6.7 1.0014 -0.74688 0 10.4539 0 0 0 0 0 0 0 9.23654 0 0 0 0 0 A0A8I3P099 A0A8I3P099_CANLF GLI family zinc finger 3 GLI3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] AENSELLSPG;GGCAAAAK;LVVHMRRHTGEKPHKCT;PIMDSTISTATT;PRDCQEDESPGQTYHRE;PYMDYIRSLHSPSLS;SPSLSMISAARGLSPTDA;TPAQQYRLKAKY 8 6.5 0.98297 0.046227 0 0 0 3.92277 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P0A6 A0A8I3P0A6_CANLF Peptidase M60 domain-containing protein TCAF2 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244] AEGGGLLIGGQAWWW;KKFSEKVQKNLAPFF;NLAPFFEAWGWPVQKD;QACGVQAQVQSDLGPPLG;VGWLCASPGAPTGVHPSLE;VTSVAGVYFTD 6 9.6 0.73487 0.24541 9.58613 0 0 0 5.72659 0 0 11.3215 0 0 0 0 0 0 9.29398 A0A8I3P0A8 A0A8I3P0A8_CANLF Rho guanine nucleotide exchange factor 4 ARHGEF4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] DEAGSEEDLYEDM;HVTMDDQELGFKAGDVIEVMDATNR;KRCWNHHGLSITPSLRDLPGSE;QEEPRGTGPAPNIA;QKQRWLKAF;RAQSPKAGRGVGGAED;TDPFESASDTESLPG;VLHCSGGDE 8 6.7 0.98813 -0.5055 10.7724 0 0 0 0 7.9438 0 0 8.70929 4.43543 0 0 10.8894 0 0 A0A8I3P0B1 A0A8I3P0B1_CANLF Aryl hydrocarbon receptor nuclear translocator ARNT Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] CDDDQMSN;DQMSNDKE;EFISRHNIEGIFTFVDHRCVAT;EQHVQQPSAQQ;MTSDVPSLGPA 5 7.3 1.0024 -1.8579 0 0 0 0 0 8.02098 0 0 0 0 10.551 0 0 10.0783 8.19027 A0A8I3P0B4 A0A8I3P0B4_CANLF Olfactory receptor OR7A71 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVSEFLLLGFSEGPELQ;LESIMVLCL;MSILNSLLESI 3 9.8 1.0025 -1.1665 0 0 0 9.33715 0 0 6.2672 0 0 0 0 0 0 0 0 A0A8I3P0B8 A0A8I3P0B8_CANLF "Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (Growth arrest and DNA damage-inducible proteins-interacting protein 1)" GADD45GIP1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] RLPGPWWPDPD 1 5 0.99383 -0.18839 0 0 0 0 0 0 0 0 0 0 9.09906 0 0 0 0 A0A8I3P0C2 A0A8I3P0C2_CANLF Growth differentiation factor 1 GDF1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] VLFFDNSDNVVLRHY 1 4.1 0.95136 0.053885 0 0 0 8.70629 8.92769 0 0 0 0 0 0 0 0 0 0 A0A8I3P0C6 A0A8I3P0C6_CANLF Claudin CLDN24 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] GHYAGAET 1 3.6 0.98822 -0.26458 0 0 0 0 8.4051 0 0 0 0 0 0 0 0 0 0 A0A8I3P0D1 A0A8I3P0D1_CANLF Glutathione synthetase (GSH-S) (EC 6.3.2.3) GSS Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; glutathione binding [GO:0043295]; glutathione synthase activity [GO:0004363]; magnesium ion binding [GO:0000287] ELARQAVDRALAE;VSYAPFTLFP 2 6.3 0.99068 -0.53872 3.76744 0 0 0 0 0 0 0 0 0 9.54292 0 10.3496 0 0 A0A8I3P0D8 A0A8I3P0D8_CANLF DNA-directed RNA polymerase III subunit RPC9 CRCP Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] RNA polymerase III complex [GO:0005666] nucleotide binding [GO:0000166] AAHRWPRKPRRLRRRGTRLR;RRAAHRWPRKPRRLRRRGTRLR 2 12.6 0.92911 0.094905 0 0 0 0 0 0 3.91924 0 0 0 0 0 0 4.94017 0 A0A8I3P0D9 A0A8I3P0D9_CANLF Olfactory receptor OR10T1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSILVLLVPLVLIFI 1 4.8 0.95064 0.053874 0 0 0 4.5008 0 0 0 0 0 0 0 0 5.55394 0 0 A0A8I3P0E3 A0A8I3P0E3_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC119866316 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] MMQMIAGTW;PHSGSAYLYTYITI;TVVVLLLVLII 3 5.9 0.99067 -0.21051 0 0 0 0 0 0 0 0 0 0 3.27572 0 3.27284 9.55229 0 A0A8I3P0E5 A0A8I3P0E5_CANLF "Type 2 lactosamine alpha-2,3-sialyltransferase (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (Sialyltransferase 10)" ST3GAL6 Canis lupus familiaris (Dog) (Canis familiaris) glycolipid biosynthetic process [GO:0009247]; protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] "beta-galactoside alpha-2,3-sialyltransferase activity [GO:0052798]" CDLFDEFDKMNNG;DKMNNGPVLGHEEEV 2 8.3 0.99218 -0.20715 0 0 0 0 0 0 0 0 0 12.1017 8.41134 0 0 0 0 A0A8I3P0F7 A0A8I3P0F7_CANLF Cysteine and serine rich nuclear protein 3 CSRNP3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific DNA binding [GO:0043565]" EEEDEEEEEDEDDKGDSFVDGL;EEEEEEEEEEEEEEEEEDGSS;EEEEEEEEEEEEEEEEEEED;GEEEEEEEEEEEEEEEEEEE;LDCQGEEEEEEEEEEEEEEE;SESEEEEEEEDEEE;TSVPSQGG;TVESEEASTLT 8 12.7 0.93047 0.10747 0 0 0 0 7.67243 0 0 0 0 0 0 0 0 5.42975 0 A0A8I3P0G8 A0A8I3P0G8_CANLF Progestin and adipoQ receptor family member 3 PAQR3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; protein localization to Golgi apparatus [GO:0034067] Golgi apparatus [GO:0005794]; membrane [GO:0016020] metal ion binding [GO:0046872]; signaling receptor activity [GO:0038023] LAVFFAQIH;SGVFYAFYCNNYWRQVYLITVL 2 10 0.99485 -0.18978 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.51751 A0A8I3P0H0 A0A8I3P0H0_CANLF Uncharacterized protein TMEM269 Canis lupus familiaris (Dog) (Canis familiaris) LESENWKKLV 1 4.9 0.99884 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.05588 A0A8I3P0H2 A0A8I3P0H2_CANLF Taste receptor type 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] EVVTYASICL;FHLFDVMLMW;IVASLAASWFCLHGV 3 11.6 1.0023 -0.84333 0 0 0 0 0 9.3125 0 0 0 0 0 0 7.7226 0 0 A0A8I3P0I2 A0A8I3P0I2_CANLF "Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb)" LOC100684983 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respirasome [GO:0005746]; respiratory chain complex IV [GO:0045277] TATQIGIEWNLSP 1 21.7 0.98323 -0.25207 0 0 0 9.7912 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P0I7 A0A8I3P0I7_CANLF KLF transcription factor 1 KLF1 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; ubiquitin-dependent protein catabolic process [GO:0006511] chromatin [GO:0000785]; nucleoplasm [GO:0005654] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin binding [GO:0043130] SEEVQDLGPGPPDP 1 3.8 0.9926 -0.16811 9.97957 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1018 A0A8I3P0J1 A0A8I3P0J1_CANLF Male germ cell associated kinase MAK Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; intraciliary transport [GO:0042073]; negative regulation of non-motile cilium assembly [GO:1902856]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494] axoneme [GO:0005930]; centrosome [GO:0005813]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; transcription coactivator activity [GO:0003713] EDPQGNLGSYATY;LMGKSNESGELV;PIEKLSCNESFP;VGSIMAELYT;YVSTRWYRA 5 8.6 1.0019 -0.99477 0 0 0 0 0 0 0 0 10.0017 0 0 9.42211 0 10.9408 0 A0A8I3P0J6 A0A8I3P0J6_CANLF Alpha-galactosidase (EC 3.2.1.-) NAGA Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; lipid metabolic process [GO:0006629] lysosome [GO:0005764] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" NFGLSFEQARAQ 1 3.1 0.99069 -0.26683 0 0 0 0 0 0 0 0 0 0 0 0 0 9.24403 0 A0A8I3P0J9 A0A8I3P0J9_CANLF Katanin regulatory subunit B1 like 1 KATNBL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KLRKVIYRRKKV 1 7.1 0.94799 0.05044 0 0 0 0 0 3.20835 0 0 0 0 0 0 0 0 0 A0A8I3P0K5 A0A8I3P0K5_CANLF Phosphomannomutase (EC 5.4.2.8) PMM1 Canis lupus familiaris (Dog) (Canis familiaris) GDP-mannose biosynthetic process [GO:0009298]; mannose metabolic process [GO:0006013]; protein N-linked glycosylation [GO:0006487] cytosol [GO:0005829] metal ion binding [GO:0046872]; phosphomannomutase activity [GO:0004615] QDTVQRCR 1 3.1 1.0033 -1.1044 0 0 9.93845 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P0L3 A0A8I3P0L3_CANLF Small cysteine and glycine repeat containing 2 SCYGR2 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCCGCCGGCCSVP;CCCGCCGGCCSVPVVCCCR;CCCRRSCGCSSCGCSSCGC;CCGCCGGCCSVP;CCGCGGCGGCSSGCGGCGSC;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSV;CCPCCCGCCGGCCSVPVVCCC;CCSSCCPCCC;CCSSCCPCCCGCCG;CCSSCCPCCCGCCGG;CCSSCCPCCCGCCGGC;CCSSCCPCCCGCCGGCCS;CCSSCCPCCCGCCGGCCSVP;CCSSCCPCCCGCCGGCCSVPV;CGCGGCGGCSSGCGGCGSCGG;CGCSSCGCGKGCCQQKCCQ;CGCSSCGCSSCGCGKG;CGCSSCGCSSCGCGKGCC;CGCSSCGCSSCGCGKGCCQQ;CGCSSCGCSSCGCGKGCCQQKCCQQ;CGGCGGCGG;CGGCGGCGGCGGCGGCGG;CGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGSCT;CGSCGGCGGCGGC;CGSCGGCGGCGGCGGC;CGSCGGCGGCGGCGGCGG;CGSCGGCGGCGGCGGCGGC;CPCCCGCCGGCC;CPCCCGCCGGCCSVP;CPCCCGCCGGCCSVPVVCCCRRSCG;CRCYRVGCCSSCCPCCCGCCGGC;CSSCCPCCCGCCGGCCSV;CSSCCPCCCGCCGGCCSVP;CSSCCPCCCGCCGGCCSVPVVCCC;CTTCRCYRVGCCSSCCPCCCG;CYRVGCCSSCCPCCCGC;CYRVGCCSSCCPCCCGCC;CYRVGCCSSCCPCCCGCCG;CYRVGCCSSCCPCCCGCCGGCC;CYRVGCCSSCCPCCCGCCGGCCSV;GCCGCGGCGGCSSGCGGCGSC;GCCGCGGCGGCSSGCGGCGSCGG;GCCGGCCS;GCCSSCCPCCCGC;GCCSSCCPCCCGCCGGC;GCCSSCCPCCCGCCGGCC;GCCSSCCPCCCGCCGGCCSVP;GCGGCGGCGGCGGC;GCGGCGGCGGCGGCGGCGG;GCGGCGSCGGCGGCGG;GCGGCGSCGGCGGCGGCGG;GCSSCGCSSC;GCSSGCGG;GCSSGCGGCGSCGGCGGCGG;GGCGGCGGC;GGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGCGG;GGCGGCGGCGGCGGCGGSCT;GGCGGCGGCGGCGGCGGSCTTC;GGCGGCSSGCGGCGSCGGCGGCGGC;GGCGSCGGCGGCGGCGGCGGCGGC;GGCSSGCGGCGSCGGCGGCGG;GSCTTCRCYRVGCCSSCCPCCCG;GSCTTCRCYRVGCCSSCCPCCCGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCG;MGCCGCGGCGGCSSGCGGCGSC;MGCCGCGGCGGCSSGCGGCGSCG;PCCCGCCGGCC;PCCCGCCGGCCSV;RCYRVGCCSSCCPCCCGCCGG;RVGCCSSCCPCCCGCCGGCC;RVGCCSSCCPCCCGCCGGCCS;RVGCCSSCCPCCCGCCGGCCSV;SCCPCCCGCC;SCCPCCCGCCGGCCSVPV;SCCPCCCGCCGGCCSVPVVCC;SCCPCCCGCCGGCCSVPVVCCC;SCGCGKGC;SCGCSSCGCSSC;SCGCSSCGCSSCGCGKGCCQ;SCGGCGGCGGCGGC;SCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGGCGGCG;SGCGGCGSCGGCGGCGGCG;SGCGGCGSCGGCGGCGGCGGC;SGCGGCGSCGGCGGCGGCGGCGG;SSCCPCCCGCC;SSCCPCCCGCCG;SSCCPCCCGCCGG;SSCCPCCCGCCGGC;SSCCPCCCGCCGGCCSV;SSCCPCCCGCCGGCCSVPVVCCC;SSCGCSSCGCG;SSGCGGCGSCGGCGGCG;SSGCGGCGSCGGCGGCGG;SSGCGGCGSCGGCGGCGGCGGCG;SSGCGGCGSCGGCGGCGGCGGCGGC;TCRCYRVGCCSSCCPCCCGCCG;VGCCSSCC;VGCCSSCCPC;VGCCSSCCPCC;VGCCSSCCPCCC;VGCCSSCCPCCCGC;VGCCSSCCPCCCGCC;VGCCSSCCPCCCGCCGG;VGCCSSCCPCCCGCCGGC;VGCCSSCCPCCCGCCGGCCSV;VGCCSSCCPCCCGCCGGCCSVP;VGCCSSCCPCCCGCCGGCCSVPV;VGCCSSCCPCCCGCCGGCCSVPVV;YRVGCCSSCCPCCCGCC;YRVGCCSSCCPCCCGCCGGCCS;YRVGCCSSCCPCCCGCCGGCCSVP 124 91.6 0.99682 -5.1637 11.0918 11.8123 9.54659 11.1097 11.1286 10.5452 12.0272 11.1929 11.2504 10.9129 10.6961 10.6216 12.5601 11.9202 11.5892 A0A8I3P0L4 A0A8I3P0L4_CANLF DUF4795 domain-containing protein QRICH2 Canis lupus familiaris (Dog) (Canis familiaris) ETRPAALESQ;GLVQPGADQLGLVQPGADQRDLVQP;GQPGLVQPAMDQRGL;IHFGGSVKASSQMIRELLQAQC;PGAYLPDWVQPGP;SLDPKQIYTVDQ;SMSQFRKESDRRRMREPQLHSLA;STLLSMSMAP;SVQLGMDQRGL;TDQQRLELPSTGQPGM;VGPGLPGHRSIRPYTIFEL;YHSLEKLEKEKANREHLEME 12 7.6 0.85935 0.14671 0 10.2555 0 0 0 0 10.4715 10.5965 0 0 0 0 0 0 0 A0A8I3P0L5 A0A8I3P0L5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] dynein complex [GO:0030286] dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959] DILAQYCKEIDI;EQTKLPIVRKV;EVLTKLILKNLQSFNSLI;LFKLHMEASDNVRFL;PGVKEFFEH;QEVEEILDSDRGREVKQ;VLTKLILKNLQ 7 8.5 1.0025 -0.73889 0 0 0 4.66488 0 0 0 0 0 0 3.37796 0 5.93442 0 11.6524 A0A8I3P0M6 A0A8I3P0M6_CANLF Olfactory receptor OR10T2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LHTPMYGFLFILSFSESCYTFVII 1 7.6 0.99414 -0.28446 0 0 0 0 0 0 0 0 16.7927 0 0 0 0 0 0 A0A8I3P0M7 A0A8I3P0M7_CANLF phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) PHYH Canis lupus familiaris (Dog) (Canis familiaris) fatty acid alpha-oxidation [GO:0001561] phytanoyl-CoA dioxygenase activity [GO:0048244] IQDYDEKTPRVHLV;LVMEKGDTVFFH 2 7.3 0.91393 0.11153 0 0 0 0 0 0 0 10.8276 9.52521 0 0 0 0 0 0 A0A8I3P0N2 A0A8I3P0N2_CANLF Elongation factor for RNA polymerase II 2 ELL2 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] transcription elongation factor complex [GO:0008023] DSNEGVKEGCTASTE 1 2.6 0.95297 0.053883 0 0 0 0 0 0 0 0 0 4.33521 0 0 0 0 0 A0A8I3P0N6 A0A8I3P0N6_CANLF Coiled-coil domain containing 85B CCDC85B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599] adherens junction [GO:0005912]; centrosome [GO:0005813]; nucleus [GO:0005634] delta-catenin binding [GO:0070097] NRELRDLCCFLDSERQ;QGHLGEIRELK 2 13.4 0.99183 -0.54229 0 0 0 0 0 0 0 0 0 0 9.96574 0 0 0 0 A0A8I3P0N8 A0A8I3P0N8_CANLF Nuclear receptor coactivator 6 NCOA6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] transcription coactivator activity [GO:0003713] LFPPQINI;MPDVSMQQSNMVPPHVQAM;NKPKKKKPPRKK;PVPPGWNQLPSGALQP;SHGHHFPNVAAPTQ;TLPTSVRSIVTTLVPS 6 4.2 0.98657 -0.33088 0 0 0 0 8.10575 7.23726 0 0 4.72836 4.14698 4.96139 0 0 0 9.58432 A0A8I3P0P0 A0A8I3P0P0_CANLF "WD repeat containing, antisense to TP73" WRAP73 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857] centrosome [GO:0005813]; ciliary basal body [GO:0036064] RHILNTTEFH 1 2.2 0.98882 -0.26445 0 0 0 0 0 0 0 0 0 0 0 0 9.09424 0 0 A0A8I3P0P8 A0A8I3P0P8_CANLF ER membrane protein complex subunit 10 EMC10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] EMC complex [GO:0072546] membrane insertase activity [GO:0032977] GGGGGGGG;GGGGGGSG;KNPQEQKSFFAKYW 3 10.3 0.94402 0.087646 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1394 A0A8I3P0P9 A0A8I3P0P9_CANLF MYG1 exonuclease MYG1 Canis lupus familiaris (Dog) (Canis familiaris) locomotory exploration behavior [GO:0035641] mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] AFRCEALPYTL;VYLHFGHKLLAQLLGTSEE 2 6.2 0.94773 0.085044 0 0 0 0 0 0 7.63408 9.98542 0 0 0 0 0 0 0 A0A8I3P0R0 A0A8I3P0R0_CANLF "FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1)" FARP1 Canis lupus familiaris (Dog) (Canis familiaris) enzyme-linked receptor protein signaling pathway [GO:0007167]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; Rac protein signal transduction [GO:0016601] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; filopodium [GO:0030175] cytoskeletal protein binding [GO:0008092]; guanyl-nucleotide exchange factor activity [GO:0005085] CKSFWKICV;IVKQIRRPKHVVVKFVVKFFPPDHT;MENFQKLHELK;PAGGGKAA;RPKHVVVKFVVKFFPPDHTQLQE;VFQGFTKINA 6 6.4 1.0024 -1.859 0 8.77446 0 0 0 0 0 0 0 8.98672 3.98432 0 5.13393 0 10.825 A0A8I3P0R2 A0A8I3P0R2_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) JOSD2 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] QLFSQEAADEICKRLA 1 8.5 0.98322 -0.25557 0 0 0 0 0 0 0 0 0 8.78953 0 0 0 0 0 A0A8I3P0R4 A0A8I3P0R4_CANLF Olfactory receptor OR4D1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SISYTVMTPMLNP;YSTVTSPKMLVDFFHE 2 9.3 0.85983 0.16264 0 0 0 0 0 0 0 0 10.7556 6.97911 0 0 0 0 0 A0A8I3P0R7 A0A8I3P0R7_CANLF Cold shock domain containing C2 CSDC2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] cytoplasm [GO:0005737] mRNA 3'-UTR binding [GO:0003730] DIEGEYVPVEGDEV 1 9.2 0.98911 -0.1968 0 0 0 0 0 0 0 0 0 0 0 9.69879 0 0 0 A0A8I3P0S8 A0A8I3P0S8_CANLF Nitric oxide synthase trafficking NOSTRIN Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] HLVESSKQT;TLENCYQSILELEKE;TVTKKEKQKLLSKLKKSTEK 3 10 0.99063 -0.21358 0 0 0 0 0 0 0 0 0 4.95056 6.32115 0 0 0 0 A0A8I3P0T7 A0A8I3P0T7_CANLF Abl interactor 2 ABI2 Canis lupus familiaris (Dog) (Canis familiaris) filopodium [GO:0030175]; lamellipodium [GO:0030027] PGNYVESI;VFPGHPVQFYSMN;YTKDKEDELSFQEGAIIYVI 3 8.6 1.0022 -1.2973 0 0 9.26437 0 0 0 0 0 0 9.39354 0 0 0 0 0 A0A8I3P0U3 A0A8I3P0U3_CANLF APC membrane recruitment protein 2 (Protein FAM123A) AMER2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DMDSHCDCAAET;EEDGPRASAPRQS;GGGGGGGG;KIPVSKVLVRRVSSRGLAG;TASLECVQEE 5 11.8 0.99155 -0.1344 0 0 5.86458 0 0 0 9.98897 0 0 0 0 5.42028 0 0 0 A0A8I3P0U9 A0A8I3P0U9_CANLF Nucleoporin 62 NUP62 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; centriole assembly [GO:0098534]; mitotic centrosome separation [GO:0007100]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of centriole replication [GO:0046601]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of protein localization to centrosome [GO:1904781]; protein transport [GO:0015031]; regulation of mitotic spindle organization [GO:0060236] centrosome [GO:0005813]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; mitotic spindle [GO:0072686]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922] Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; PTB domain binding [GO:0051425]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; structural constituent of nuclear pore [GO:0017056]; ubiquitin binding [GO:0043130] DPLQQICKILNAHMD;NFGGTGAP 2 4.4 1.0034 -1.1044 0 0 0 0 0 0 0 0 6.36161 0 0 0 0 0 0 A0A8I3P0V5 A0A8I3P0V5_CANLF Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) WDR12 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; regulation of cell cycle [GO:0051726]" "nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021] HCCRGHAGS;TRSCKAPLYDLAAH;VGHTDVVKD 3 7.6 1.0038 -1.0597 0 0 0 7.37252 7.57425 9.4615 0 0 0 0 0 0 0 0 0 A0A8I3P0W1 A0A8I3P0W1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHNHYTQKSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;EALHNHYTQKSLSHSPG;EDGSYFLYSKL;EIISKTPGQAHQPNV;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;FLYSKLSVDKSR;FPSVLQSSGL;FVDSKQVQTA;GPSVFIFPPKPKD;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GTYRVVSVLPIGHQD;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HNHYTQKSLSHSPG;HTFPSVLQSSGL;HYTQKSLSHSPG;IFPPKPKD;IISKTPGQA;IISKTPGQAHQPNV;ISSDGSSTSYADA;KGVQGGEVQLVESGGDLVKPG;KLSVDKSR;LHNHYTQKSLSHSPG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTQKSLSHSPG;NKALPSPIEE;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;PENPEVQIS;QKSLSHSPG;QLVESGGDLVKPG;QSSGLYSLSSM;SGGDLVKPG;SGGDLVKPGG;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TFPSVLQSSGL;TPPQLDEDGSYFL;TQKSLSHSPG;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TYRVVSVL;TYRVVSVLPIG;TYRVVSVLPIGHQD;VESGGDLVKPG;VESGGDLVKPGG;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VMHEALHNHYTQKSLSHSPG;VQLVESGGDLVKPG;VTVPSSRWPSET;VTVSWNSGSLTSGVHTFPSVL;VVSVLPIGHQD;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTQKSLSHSPG 117 43.2 0 1.9766 11.434 10.5806 11.0877 8.56525 8.81538 9.00487 11.2084 8.56362 8.88893 10.6038 11.6525 10.7092 11.6129 11.4821 0 A0A8I3P0W8 A0A8I3P0W8_CANLF Protein cornichon homolog 2 (Cornichon family AMPA receptor auxiliary protein 2) CNIH2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] COPII-coated ER to Golgi transport vesicle [GO:0030134]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; postsynaptic density [GO:0014069] LFCLMFLCAAE 1 6.9 0.99209 -0.17967 0 0 0 0 0 0 0 0 0 0 11.5656 0 0 0 0 A0A8I3P0Y0 A0A8I3P0Y0_CANLF Nuclear protein MDM1 MDM1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of centriole replication [GO:0046600] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634] microtubule binding [GO:0008017] PKPEAPETELQEAEQK;VSSGKEGRLPTPK 2 4.3 0.94153 0.05986 0 0 0 8.24783 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P0Y9 A0A8I3P0Y9_CANLF "ST3 beta-galactoside alpha-2,3-sialyltransferase 3" ST3GAL3 Canis lupus familiaris (Dog) (Canis familiaris) ganglioside biosynthetic process via lactosylceramide [GO:0010706]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity [GO:0003836]" EDSSKYGC;GLLVFVRNLL;VTKEYRLTPALDSLSCR 3 9 1.0031 -0.7318 10.6362 0 8.5995 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P0Z2 A0A8I3P0Z2_CANLF "SEC31 homolog B, COPII coat complex component" SEC31B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum membrane [GO:0005789] ADAIILAQAGG;IFTPQSSLVTP;ISQTQNISDYRAPG;LDASFSTSG;NLLNYCQNKIEQTSLQ;SEDDRFPVI 6 6.3 0.98531 -0.23616 10.4511 0 0 7.86629 0 10.2215 0 0 0 0 0 5.91581 0 0 0 A0A8I3P111 A0A8I3P111_CANLF Golgi associated RAB2 interactor 5A GARIN5A Canis lupus familiaris (Dog) (Canis familiaris) DESRWQLKVKFRTGRAFY;EGAVPFTQEYLTMEDGEYDEDDED;FPIFESNFVQVTR;QEYLTMEDGEYDEDDEDEEEDD 4 27.3 1.0026 -0.7976 0 0 0 0 9.53101 0 0 0 7.02115 0 0 0 0 0 8.82206 A0A8I3P114 A0A8I3P114_CANLF Trinucleotide repeat containing 18 TNRC18 Canis lupus familiaris (Dog) (Canis familiaris) chromatin binding [GO:0003682] AFPPGLGGSLPS;AGGWQEPKGLLGL;DDSSCSSDDE;ERIFLHDASAAAPAP;FYHPEETSPGKRLHE;GEAEVRHPP;GPAAAECKGKNP;HGITLLSE;KDFMERALYQ;KNGKLAGGPKLTKRGLAAARTLK;PPRVPALPP;RQLKRDPERPESAK;SSSSSETEGEEEGQ;TDDSSCSSDDE;VVEKKDLELEKEAPSP 15 6.3 0.99869 -2.9885 9.86408 13.2758 0 0 0 0 6.8913 0 9.23161 0 0 4.44221 8.26997 8.81705 14.0756 A0A8I3P116 A0A8I3P116_CANLF Uncharacterized protein LOC486150 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] vitamin transmembrane transporter activity [GO:0090482] LEEPQTDHKP;LSRNQDDGPLSTP;YSSKHLFYWSL 3 6.9 1.0027 -0.8397 0 9.28418 0 0 0 7.83232 9.52787 0 0 0 0 0 0 0 0 A0A8I3P118 A0A8I3P118_CANLF SMCR8-C9orf72 complex subunit SMCR8 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of TOR signaling [GO:0032008]; regulation of TORC1 signaling [GO:1903432] Atg1/ULK1 kinase complex [GO:1990316]; chromatin [GO:0000785]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; presynapse [GO:0098793] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] GESIEVLGTEKSTSVLAKSDS;IPDDFKASYPSAINEE;NSDTTSNLSSIAST;VEKSIIEHQDLLKQ 4 7 0.99112 -0.14549 0 8.73346 0 0 0 0 0 7.31352 0 0 0 0 0 4.96019 0 A0A8I3P125 A0A8I3P125_CANLF M-phase phosphoprotein 6 MPHOSPH6 Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460] EEEEKKIISEEHWY;RGVARTGG 2 5.7 1.0031 -1.0273 0 0 8.4079 0 0 0 0 0 0 0 0 11.6944 0 0 0 A0A8I3P134 A0A8I3P134_CANLF Alpha tocopherol transfer protein like TTPAL Canis lupus familiaris (Dog) (Canis familiaris) MVRKECPTLSTSLDDA 1 4.7 0.99129 -0.2219 0 11.1099 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P139 A0A8I3P139_CANLF Growth differentiation factor 7 GDF7 Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching morphogenesis of an epithelial tube [GO:0048754]; cell fate commitment [GO:0045165]; epithelial cell differentiation [GO:0030855]; forebrain morphogenesis [GO:0048853]; gland morphogenesis [GO:0022612]; midbrain development [GO:0030901]; morphogenesis of an epithelial fold [GO:0060571]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of tendon cell differentiation [GO:2001051]; reproductive structure development [GO:0048608]; roof plate formation [GO:0021509]; spinal cord association neuron differentiation [GO:0021527] extracellular region [GO:0005576] growth factor activity [GO:0008083]; identical protein binding [GO:0042802] ESPGPGAG;GGGGGGGG;IDAANNVVYKQY;PGGGGGGG;RALAPAAG 5 8.2 1.0031 -2.1583 0 0 9.51195 0 0 8.87104 0 0 0 0 11.83 0 0 0 0 A0A8I3P157 A0A8I3P157_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IILSYIFIVA;LSYIFIVAAI;MATTYTVFTPFLSPIIFSLRNKELK 3 11.8 0.99196 -0.55095 0 0 0 0 0 0 0 0 0 0 0 0 10.1577 0 8.98071 A0A8I3P162 A0A8I3P162_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AQSYRWELG;LPEAQESMEAAQ;LVCLLSWMT 3 30.8 1.0024 -1.8599 0 0 0 0 0 0 0 10.1997 0 0 0 0 9.32096 0 0 A0A8I3P163 A0A8I3P163_CANLF Collagen type I alpha 2 chain COL1A2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] ERGYPGNIGPVGAVGAPGPHGPV;ETLLTPEG;GVMGPPGP;NPGPAGPA;PGAPGPKGE;TAGASGPGGLPGE;VVELEQSRAAQ 7 6.3 0.99947 -2.8551 0 10.0095 0 0 0 8.20692 11.5303 9.04753 0 0 0 10.3218 0 0 0 A0A8I3P175 A0A8I3P175_CANLF Zinc finger and SCAN domain containing 26 NKAPL Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] chromatin binding [GO:0003682] KEKKKKHRARKNKKKK;RRLKERERIGE;SDMDSSSDDD 3 9.1 1.0029 -0.8637 5.02144 0 0 0 0 4.02263 0 0 0 0 4.87096 0 6.05302 0 0 A0A8I3P177 A0A8I3P177_CANLF Family with sequence similarity 13 member A FAM13A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DLERDMQKP;KHGLTQEGLFRVNGN;LEVLISKR;PYWDDMSSAEDANV;QQESVDSDEARLSPQAG;RSAVEQHLF 6 6.8 1.0025 -1.1466 0 10.4856 0 0 10.6199 6.65148 0 0 0 0 0 0 10.3996 0 0 A0A8I3P181 A0A8I3P181_CANLF Uncharacterized protein HNRNPA1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013] mRNA 3'-UTR binding [GO:0003730] EEHHLRDY;NNGGGGGG;SGSGNFGG 3 6.4 1.0042 -1.1044 0 9.90513 0 0 0 0 10.4956 0 0 0 0 0 0 0 0 A0A8I3P188 A0A8I3P188_CANLF Ig-like domain-containing protein LOC111092148 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESERVLTCKVQH;PHLLSPSV;VHLSRDTY 3 5.4 1.0032 -1.6244 0 12.0488 12.0708 0 0 0 10.2829 0 12.0163 11.8866 12.1788 0 12.1582 12.0894 12.1798 A0A8I3P193 A0A8I3P193_CANLF BTB domain containing 17 BTBD17 Canis lupus familiaris (Dog) (Canis familiaris) AGPAVGWYHYAV;QAAGTDEVRVFHTHR 2 5.6 0.9922 -0.20807 0 0 0 9.44661 0 0 0 0 0 9.52491 0 0 0 0 0 A0A8I3P198 A0A8I3P198_CANLF TNF receptor-associated factor TRAF3 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; Toll signaling pathway [GO:0008063]; tumor necrosis factor-mediated signaling pathway [GO:0033209] cytoplasm [GO:0005737] tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270] LVLCNPKQTECGHRF;QTVLENGTYIKDDTI;VLIWKIRDYKRRKQ;VLRRDLRDHVE;VSLLQNESVEKNKSIQSLH 5 15.3 0.99337 -0.027022 0 0 5.57101 0 9.43557 4.19676 6.37829 0 0 0 0 0 0 9.4307 0 A0A8I3P1A0 A0A8I3P1A0_CANLF Ubiquitin conjugating enzyme E2 T UBE2T Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; chromatin binding [GO:0003682]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625] TVLTSIQL 1 3.8 0.99012 -0.26196 0 0 0 0 0 0 0 10.2906 0 0 0 0 0 0 0 A0A8I3P1A6 A0A8I3P1A6_CANLF Centrin 3 CETN3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EDFNEVGVYFNSLCNHLL 1 16.4 0.98028 0.048313 0 0 0 0 0 0 0 0 0 0 7.98988 0 0 0 0 A0A8I3P1B1 A0A8I3P1B1_CANLF "Testis expressed 15, meiosis and synapsis associated" TEX15 Canis lupus familiaris (Dog) (Canis familiaris) homologous chromosome pairing at meiosis [GO:0007129]; male meiotic nuclear division [GO:0007140]; regulation of double-strand break repair via homologous recombination [GO:0010569] CKNKVSLDPS;DIQARTMWKTKQAE;ESIIIFKVL;ESYLDKQRIFAKDS;GEPTFRSLLWYDE;GFSPTSESLALKDKFCK;GNVQNGNISIHETYNGQKEH;INPSNANISNTYGNVQNG;LHNDIHLNIDFKEQ;QCEDSQEQEKNTTVFN;QELTLRCTEHLEI;SALIARLIQILRR;SGVLPEAPWTYVPCQQEPF;SQAHNLDFQSY;SSKPGIITEDFLMDPL;VGSEQCND;VLDILNTEASLCKS;YSSIQKNKAELC 18 7.7 1.0008 -2.7375 11.0701 9.14078 0 0 6.51956 8.3856 0 8.23563 11.9253 9.59369 8.99529 10.2129 0 11.5654 8.62421 A0A8I3P1D0 A0A8I3P1D0_CANLF Kazal type serine peptidase inhibitor domain 1 KAZALD1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; regulation of cell growth [GO:0001558] extracellular region [GO:0005576]; interstitial matrix [GO:0005614] insulin-like growth factor binding [GO:0005520] ALPSLLLLLLLR;DACGCCWEC 2 7 1.0015 -0.75377 0 0 0 0 0 3.33743 4.95958 0 0 0 0 0 0 0 0 A0A8I3P1D3 A0A8I3P1D3_CANLF HECT and RLD domain containing E3 ubiquitin protein ligase 3 HERC3 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] EETAIYKGDYSATHPT;FSSGFLKVCGGKVLELFQ;GVFTFGAGSCGQLGH;LEKKKKFLL;QIVIQSTASGEE 5 8.1 1.0029 -1.1613 0 10.2446 0 6.32614 0 0 0 0 9.35909 0 0 0 6.8759 0 0 A0A8I3P1D4 A0A8I3P1D4_CANLF tRNA-queuosine alpha-mannosyltransferase (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1) GTDC1 Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] ALRPDLGKLKKIL;LSKRLQNFC;SREHDKDPESFFKVL;TSASVRLDICEERN 4 12.1 0.99341 -0.55717 0 0 0 0 0 10.2339 0 0 10.3009 0 0 0 0 0 9.49831 A0A8I3P1D6 A0A8I3P1D6_CANLF HIG1 hypoxia inducible domain family member 1C HIGD1C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLYSMYKDYIRPRFF 1 15.5 0.95054 0.053889 0 0 0 0 0 0 7.28179 0 0 0 0 0 0 0 0 A0A8I3P1E6 A0A8I3P1E6_CANLF PR/SET domain 8 PRDM8 Canis lupus familiaris (Dog) (Canis familiaris) corpus callosum morphogenesis [GO:0021540]; corticospinal tract morphogenesis [GO:0021957]; methylation [GO:0032259] nuclear body [GO:0016604] chromatin binding [GO:0003682]; histone H3K9 methyltransferase activity [GO:0046974]; transcription corepressor activity [GO:0003714] AFTSVPQLGAAGA;ASGGGKGK;AVQQCLTDIFTSVYTTCD;FEFPYVAHLR;GGCGALPK;GGGGGGGG;HGGGGGGK;SPYTCLECSQRFQFEFPYV;TSDLVYHMRSHHKKE;VAHLRFRCPKRLHSADA 10 17.8 0.99699 -3.9403 9.14236 10.1518 0 0 0 9.17255 10.7679 0 5.8542 9.05723 7.1417 0 9.2902 8.53695 9.35878 A0A8I3P1F3 A0A8I3P1F3_CANLF Heterogeneous nuclear ribonucleoprotein D HNRNPD Canis lupus familiaris (Dog) (Canis familiaris) "circadian regulation of translation [GO:0097167]; CRD-mediated mRNA stabilization [GO:0070934]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of telomere capping [GO:1904355]; regulation of circadian rhythm [GO:0042752]" mCRD-mediated mRNA stability complex [GO:0106002]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; synapse [GO:0045202] RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162] DEGHSNSS;SQNWNQGYSNY 2 5.4 0.99013 -0.26356 0 0 0 0 0 0 0 0 0 10.9933 0 0 9.92291 0 0 A0A8I3P1G1 A0A8I3P1G1_CANLF ZFP42 zinc finger protein ZFP42 Canis lupus familiaris (Dog) (Canis familiaris) female gonad development [GO:0008585]; male gonad development [GO:0008584] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] EPILEEESLKSLD 1 5.1 0.98845 -0.26104 0 0 0 0 0 0 0 0 0 0 0 0 9.89289 0 0 A0A8I3P1G5 A0A8I3P1G5_CANLF COUP transcription factor 2 (COUP transcription factor II) (Nuclear receptor subfamily 2 group F member 2) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] KMPGSQGS;QPQLQPQPRAQG;YRRNQCQFCRLKKCIDVGMKREA 3 10.8 0.9902 -0.53362 0 0 0 0 0 0 9.08645 0 0 11.8243 0 0 11.6991 0 0 A0A8I3P1H1 A0A8I3P1H1_CANLF Growth factor independent 1B transcriptional repressor GFI1B Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] SAFLERSVSL 1 3.6 0.98686 -0.23363 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0371 A0A8I3P1H5 A0A8I3P1H5_CANLF FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) FLAD1 Canis lupus familiaris (Dog) (Canis familiaris) FAD biosynthetic process [GO:0006747]; riboflavin metabolic process [GO:0006771] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; identical protein binding [GO:0042802] EEEERNSRT;SIAPILAEAQA 2 4.1 1.0026 -0.76872 0 0 0 0 0 0 0 0 0 0 8.87394 7.07478 0 0 0 A0A8I3P1I0 A0A8I3P1I0_CANLF BAG cochaperone 3 BAG3 Canis lupus familiaris (Dog) (Canis familiaris) protein-folding chaperone binding [GO:0051087] AEGGPLSSGGPAAGTEAPVPPGRG;TDKNKKSAGNEEDPKT 2 7.4 0.99339 -0.27932 0 0 0 0 0 0 0 10.6302 0 0 0 0 0 0 0 A0A8I3P1I4 A0A8I3P1I4_CANLF Polycomb group RING finger protein 1 PCGF1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleoplasm [GO:0005654]; PRC1 complex [GO:0035102] metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841] IVKYLQTSKYCPM 1 5 0.93732 0.073281 0 0 0 9.11598 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P1K6 A0A8I3P1K6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] AAPLGVLSELTLQES;ELTLQESG;ELTLQESGP;ELTLQESGPG;ELTLQESGPGL;ELTLQESGPGLVK;ELTLQESGPGLVKP;ELTLQESGPGLVKPS;ELTLQESGPGLVKPSQ;ELTLQESGPGLVKPSQTL;GVLSELTLQESGPGLVKP;YNPAFQGRISIT 12 33 0 80.639 13.7765 13.9511 13.8503 13.2936 13.205 13.3975 14.1984 14.3076 14.6752 14.4844 13.987 14.1097 13.7919 13.9379 13.7579 A0A8I3P1M2 A0A8I3P1M2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LMISDLYEKCW 1 10.5 0.98395 -0.24721 0 0 0 0 0 0 0 0 0 0 0 0 9.69893 0 0 A0A8I3P1N2 A0A8I3P1N2_CANLF Sin3A associated protein 30 SAP30 Canis lupus familiaris (Dog) (Canis familiaris) modulation by host of symbiont transcription [GO:0052472]; negative regulation of transcription by RNA polymerase II [GO:0000122]; skeletal muscle cell differentiation [GO:0035914] histone deacetylase complex [GO:0000118] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] GDSPVQDID;RGGDAAAAVAAVVAAAAAAASAGNG;VEIVGCHFRSIPV 3 21.4 1.0021 -1.002 0 0 6.82337 0 0 0 0 0 0 8.77393 8.35143 9.54747 8.09577 0 0 A0A8I3P1N3 A0A8I3P1N3_CANLF Alkylglycerone-phosphate synthase (Alkyl-DHAP synthase) (EC 2.5.1.26) AGPS Canis lupus familiaris (Dog) (Canis familiaris) ether lipid biosynthetic process [GO:0008611] peroxisome [GO:0005777] alkylglycerone-phosphate synthase activity [GO:0008609]; flavin adenine dinucleotide binding [GO:0050660] VELTGKRGISDPLTVFEQ;VLSGHLRGRPWE;WGYNDSKFFFNKKG 3 23.2 0.97748 0.048313 0 0 0 0 12.2802 0 0 0 0 0 0 0 0 0 0 A0A8I3P1N9 A0A8I3P1N9_CANLF Protein amnionless AMN Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] apical plasma membrane [GO:0016324]; endocytic vesicle [GO:0030139] PRMWGRLPLE;RAAWRPGCC;SGGLSASDWSPRPS;VPTTDFEAAANWSQNRTPCA;YKLWVPTTDF 5 10.1 0.99045 -0.26204 0 0 0 0 0 0 0 3.96791 0 0 0 0 0 0 0 A0A8I3P1Q2 A0A8I3P1Q2_CANLF DNA endonuclease RBBP8 RBBP8 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835]; cell division [GO:0051301]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; G1/S transition of mitotic cell cycle [GO:0000082]; meiotic cell cycle [GO:0051321] BRCA1-C complex [GO:0070533]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; transcription repressor complex [GO:0017053] damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transcription corepressor activity [GO:0003714] EYHDKEVQGLQ;TLRKILILVL 2 2.4 1.0026 -0.8951 0 0 0 0 0 0 0 0 0 0 0 5.87394 0 0 0 A0A8I3P1S6 A0A8I3P1S6_CANLF Olfactory receptor LOC119863890 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVLFIVNFTLYTVAVL 1 5.2 0.96301 0.049233 0 0 0 0 0 8.53955 0 0 0 0 0 0 0 0 0 A0A8I3P1U2 A0A8I3P1U2_CANLF Rac GTPase activating protein 1 RACGAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FSTPQTPS;SSKAGPGGG 2 13.7 0.99256 -0.27189 0 0 0 0 10.7878 0 0 0 0 0 0 0 0 0 0 A0A8I3P1U6 A0A8I3P1U6_CANLF Olfactory receptor OR2B7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVLLAVMAYDR;SLILLSYGHITRAVLKIK;VFFLVVPLSLILLSYGH;VHPQLCLWLV 4 14.5 0.99124 -0.29596 0 0 0 0 0 0 7.53364 0 0 0 0 0 11.9761 11.9332 0 A0A8I3P1U8 A0A8I3P1U8_CANLF Homeobox B3 HOXB3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cartilage development [GO:0051216]; definitive hemopoiesis [GO:0060216]; embryonic skeletal system morphogenesis [GO:0048704]; face development [GO:0060324]; glossopharyngeal nerve morphogenesis [GO:0021615]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; rhombomere development [GO:0021546]; thyroid gland development [GO:0030878] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLSSHHAPPPQGQSR;GGGGGGGD;GGGGGGGG;GGGGGGSG;PAFGKAHQN;PAPDYEPHVLQAN;VGGGGYADP 7 15.4 1.0019 -1.2619 0 0 0 0 0 0 9.85429 0 0 0 10.0988 0 0 8.06399 0 A0A8I3P1U9 A0A8I3P1U9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ESLPLDTRLGD 1 10.7 0.98733 0.035491 0 9.87203 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P1V7 A0A8I3P1V7_CANLF "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] GGGGGGGA;GGGGGGGG;GVVEFVRKE;VIRGPAGNNDC 4 12.1 0.9892 -0.22378 0 0 9.07213 8.2446 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P1X5 A0A8I3P1X5_CANLF Forkhead box B1 FOXB1 Canis lupus familiaris (Dog) (Canis familiaris) axon target recognition [GO:0007412]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammillothalamic axonal tract development [GO:0061374]; negative regulation of neuron apoptotic process [GO:0043524]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]; visual learning [GO:0008542] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RRRKRFKVLKSDHLAPS 1 5.2 0.98503 0.046227 0 0 0 0 0 0 0 0 0 4.10944 0 0 0 0 0 A0A8I3P1Y3 A0A8I3P1Y3_CANLF "SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1" SPOCK1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] CWCVDKYGNEL;GKLSNNEWCYCFQKPGGLPCQNE 2 8.9 0.99468 -0.15264 10.3357 7.03782 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P1Z3 A0A8I3P1Z3_CANLF Carboxypeptidase Q (Plasma glutamate carboxypeptidase) CPQ Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764] carboxypeptidase activity [GO:0004180]; metallodipeptidase activity [GO:0070573] LVSGHLDSWD;TDSLRWVT;VGELGTGLASL 3 6.7 1.0017 -1.2496 0 0 0 0 8.40075 0 0 0 0 0 8.42803 0 8.78106 0 0 A0A8I3P212 A0A8I3P212_CANLF Desmoplakin DSP Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; desmosome organization [GO:0002934]; epithelial cell-cell adhesion [GO:0090136]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; protein localization to cell-cell junction [GO:0150105]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; ventricular compact myocardium morphogenesis [GO:0003223] adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; intermediate filament [GO:0005882] protein kinase C binding [GO:0005080]; scaffold protein binding [GO:0097110] AVEDRFDQQ;GGGGGGGG;GVKGKKKM;IEAYMDTLQTQ;IEQYYEAI;KNKEIERLKAEFQEEAKRRWEYE;LANFRGSEKYCY;LQKVRRQM;LSVQKRSMSF;MTRAESGPDLRYEATC;QRRRAEED;QSSLKDLQLQKQK;RYKQSLDDAAKTIQDK;SPIAAIFD;TLELQGLINDLQRERE;VEENAQQQ 16 6.3 0.99706 -6.8821 0 0 0 0 0 10.5279 0 0 0 8.84021 0 10.7395 7.94848 11.4902 9.1151 A0A8I3P226 A0A8I3P226_CANLF Histamine receptor H3 HRH3 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of glutamate secretion [GO:0014050]; negative regulation of serotonin secretion [GO:0014063]; regulation of norepinephrine secretion [GO:0014061]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969] EAAPGAEAGE;EFFTPFLSVTFFN;TSSSGSSS;VGAFCIPLYVPYVL;VGVGEAAP 5 11 1.0034 -2.2107 0 0 0 0 0 0 0 0 0 10.0849 0 5.41681 0 10.3347 0 A0A8I3P231 A0A8I3P231_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) NDUFB10 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I [GO:0005747] DRQHAKNRYYYYHREFRRVPDITEC;QHAKNRYYYYHREFRRVPDITE 2 14.7 0.98767 -0.22947 0 0 0 0 0 0 9.66772 0 10.264 0 0 0 0 0 0 A0A8I3P233 A0A8I3P233_CANLF UTP23 small subunit processome component UTP23 Canis lupus familiaris (Dog) (Canis familiaris) "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]" nucleolus [GO:0005730]; small-subunit processome [GO:0032040] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027] EKKRKRKRIRNRSISKVL 1 7.3 0.97203 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.65549 A0A8I3P236 A0A8I3P236_CANLF Cytochrome P450 4A37 CYP4A37 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" EGELEKIRNKR;RFAPDASRHSH;VLLSFYALH;YQHRQWLLKAV 4 8.2 1.0037 -0.82272 0 0 0 0 0 0 0 0 0 0 9.11536 0 0 0 0 A0A8I3P240 A0A8I3P240_CANLF Telomerase RNA component interacting RNase TRIR Canis lupus familiaris (Dog) (Canis familiaris) rRNA catabolic process [GO:0016075] 3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409] GVNLFANDGSFLEL 1 7.8 0.98312 -0.25577 0 0 0 0 0 0 0 0 0 0 0 0 12.7284 0 0 A0A8I3P241 A0A8I3P241_CANLF Doublecortin domain-containing protein RP1L1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; intracellular signal transduction [GO:0035556]; visual perception [GO:0007601] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; photoreceptor outer segment [GO:0001750] AHSKSGEGLPCSGIS;DTVVREWLSNIPE;EAEGEGQPESGGGR;EEFCPCEACMR;FHLLGKDAVLWSRRVGRASALP;GTDSRRRSRLTQHS;LVCAGYESFKP;PGSRYEIWMNPL;PKAPRRIVLVK;QNDGDKSEEIQ;RITLPLKIPSP;RWEMSLQTEQRRRR;SQTLGREGDPG 13 8.9 1.0023 -1.2263 6.77386 11.1943 0 6.85225 0 0 0 0 12.8184 0 0 0 10.3437 0 8.68605 A0A8I3P249 A0A8I3P249_CANLF Cap binding complex dependent translation initiation factor CTIF Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EAGNSRSQE;VERWLGFITFLCEV 2 4 1.0045 -1.0519 8.89909 0 0 0 0 0 0 0 0 0 0 8.51479 0 0 0 A0A8I3P271 A0A8I3P271_CANLF Glutathione peroxidase GPX7 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783] catalase activity [GO:0004096]; glutathione peroxidase activity [GO:0004602] EDIRPQITALVRKLILK;VASACGFTDGHYRS 2 16.8 0.98771 -0.22423 0 0 0 0 0 0 7.7039 0 0 0 0 0 0 0 0 A0A8I3P280 A0A8I3P280_CANLF MSL complex subunit 2 MSL2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; protein ubiquitination [GO:0016567] MSL complex [GO:0072487]; nucleus [GO:0005634] ubiquitin protein ligase activity [GO:0061630] ATQNPSVL;DLSDSLPPVCDT;DPKAFTEINR;GLSIDRFGINIPSP;ISTIIRGPTLGASAPVTVKR;SLQPIATVP;SLSPISESTLSI 7 14.7 1.0006 -2.7838 0 0 6.22391 0 0 0 0 8.52713 8.20389 0 7.47735 12.7941 0 0 6.46259 A0A8I3P283 A0A8I3P283_CANLF "Zinc finger protein 598, E3 ubiquitin ligase" ZNF598 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737] ribosome binding [GO:0043022]; ubiquitin protein ligase activity [GO:0061630] CLFFFVDERKWYRSVIWYSWTPLRH;HCLFFFVDERKWYRSVIWYSWTPLR;HYFCHFCDSD;KGGRKGGP;RWEIPLVVRGKL;SSSYLTIEQK;TEGPAPARSTPKEP 7 9.3 0.9879 -0.48994 0 0 0 0 0 8.52097 7.30415 0 0 0 0 0 7.10748 7.92677 0 A0A8I3P285 A0A8I3P285_CANLF Transient receptor potential cation channel subfamily V member 5 TRPV5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074]; regulation of urine volume [GO:0035809] apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704] calcium channel activity [GO:0005262] ELVKEPTLCEPFVGQTALHIAIVN;LELVVSSK;LYMICFTTCCIYRPLKFRMGNR 3 7.4 1.003 -0.78107 0 8.49725 10.7717 6.49293 0 0 11.6822 0 0 0 0 0 8.92884 10.9912 9.13137 A0A8I3P290 A0A8I3P290_CANLF Senataxin SETX Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] ADPLAGGDPTIHHLELATLKE;AKVSKERQELASKIKE;DDDDDEEE;DSDDDDDDDDEE;IIISDSDDDDDDDD;IINNVSYNREIQNI;IISDSDDDDDDDDEEEEE;INNVSYNREIQNIRNS;ISDSDDDDDDDDEEE;ISDSDDDDDDDDEEEEEE;IVSPSADP;KIEVKKRKRKRF;SDDDDDDD;SDDDDDDDD;SDDDDDDDDEEE;SDDDDDDDDEEEE;SDDDDDDDDEEEEEE;SDSDDDDDDD;SERNEDQPDI;VETPENQGEYCSKHCEAKAADEDVF;VGDGSERRDND;VGDPKQLPPTVISM;VIIISDSDDDDDDDDEE;VISSLVTTQRKLK;YNKEESEQIERKSKKDLFCLENS 25 7.6 1.0039 -1.102 6.92065 4.88918 9.59869 11.2919 4.5885 4.68454 10.2063 6.42279 7.12608 3.5121 0 0 9.646 10.474 9.09737 A0A8I3P295 A0A8I3P295_CANLF Kinectin 1 KTN1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] kinesin binding [GO:0019894] EHLEMELEKAEIERSTYV;KDSKYQPNK;NKDIENLRREREH;VLEHKLKEADEMH 4 8.6 0.98513 -0.2378 0 0 0 9.34507 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P2C3 A0A8I3P2C3_CANLF "3-hydroxyisobutyrate dehydrogenase, mitochondrial (EC 1.1.1.31)" HIBADH Canis lupus familiaris (Dog) (Canis familiaris) valine catabolic process [GO:0006574] mitochondrion [GO:0005739] 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661] LTLLQIVLLPIKERE;TFMVGGVEDEFAAAQE;VGAARSGN 3 16.2 1.0028 -0.78006 0 0 0 0 0 0 0 0 0 0 0 7.78084 0 8.6531 17.0044 A0A8I3P2D2 A0A8I3P2D2_CANLF "5'-nucleotidase, cytosolic IB" NT5C1B Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] EIDEALFLAGAPKGP;TSRSPSTRGPSI 2 4.4 0.99509 -0.082745 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2563 14.3587 A0A8I3P2E1 A0A8I3P2E1_CANLF "Proline, glutamate and leucine rich protein 1" PELP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] AGPMPPAG;APSGTPPPAIPPDETF;APVQYEGPGVEVL;ECYSRLPSLGA;EEEEEEEEEEEEEDFEEEEEEEEY;EEEEEEEEEEEEEEDFEEEEEEEEY;EEEEEEEEEEEEEEEEEEED;EEEEEEEEEEEEEEEEEEEEEEEE;EEFEEEEGELEEEEEEEDEEEEEEL;EFEEEEGELEEEEEEEDEEEEEEL;EYFEEEEEEEEE;FEEEEEEEEYFEEEEEEEEEFEEEF;PALEEDLTVI;RVPRPAFVHYDK;SSDEEEEEEEEEEE;TVININSSDEEEEEEEEEEEEEEEE;VGSGPRLRLLLLES;VININSSDEEEEEEEEEE;VPGLVSVPPRLIPGPENHRAGSNED;WEQELHSLLAS;YFEEEEEEEEEFEEEFEEEEGEL 21 17.4 1.0029 -1.0093 5.87125 0 13.476 0 5.60733 0 9.74069 3.92676 9.02705 3.27074 0 4.27299 10.6554 6.11391 10.2454 A0A8I3P2E8 A0A8I3P2E8_CANLF Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5) SMYD5 Canis lupus familiaris (Dog) (Canis familiaris) "methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell division [GO:2000035]; retrotransposon silencing by heterochromatin formation [GO:0141005]" histone H4K20 methyltransferase activity [GO:0042799] CRLAAAEQ;LGDKFKGQLE;RFVSSAKGK;VTSEEEEEEEEEEEEGEPEDAEL 4 11.9 1.0022 -1.3694 0 0 0 0 0 0 0 6.41054 0 0 7.71239 5.5701 0 0 0 A0A8I3P2G7 A0A8I3P2G7_CANLF "Capping actin protein, gelsolin like" CAPG Canis lupus familiaris (Dog) (Canis familiaris) actin filament binding [GO:0051015] EVQGNESDLFMSYF;GGKMHALSLES;WKGGKMHALSLES 3 8.3 0.98785 -0.49347 10.6293 0 0 0 0 0 0 0 4.64801 0 0 10.1348 0 0 10.0638 A0A8I3P2I6 A0A8I3P2I6_CANLF Integrator complex subunit 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] FTKEVQQQQEE 1 2.4 0.98197 -0.25057 0 0 0 0 8.27468 0 0 0 0 0 0 0 0 0 0 A0A8I3P2I7 A0A8I3P2I7_CANLF Secernin 3 SCRN3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] LDTSSPTFGLE;LDTSSPTFGLED 2 2.8 0.98761 -0.35398 14.9322 11.1617 0 0 0 0 0 0 0 0 0 0 11.8876 0 0 A0A8I3P2J2 A0A8I3P2J2_CANLF Dynein axonemal heavy chain 17 DNAH17 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; outer dynein arm assembly [GO:0036158] microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AEMGHWVILQ;AIKDYNKKQISQLNALIT;EITITQMILYLL;ELYELYFVFA;ETLEDNQVQLQNLMMSKYLSHFLK;FEVTVPDYRQLKACHK;GLFMEGARWDTQ;GNAGTGKS;IKITNEPP;IVLYLKPLRILLE;KPNMFCHF;KVPWDDLRYLFG;LEDNQVQLQNLM;LFDAELDNAKTLYDAQ;LKELSLGLKGELTITTDMEDL;LLYFILNDL;MLELFDAELDNA;PPESPYLYGLHPNAE;QAQCTLINFLVTRDGLEDQLLA;RRKCQQFELKQHEFREKFRREAPF;SENVRWAESVKNFKSQ;SFDDDYADFETKIQDL;SLLHSIETIIID;SNHVISSLADLEAFM;SVPMVVQRMS;TQIYDEVFELVKVFAECKYDPLDP;VAPEDLDHRAQEAV;VEVLSVIA;VGNAGTGKSVLMGDKLE;VLDGDIDPMW;VMLELFDAELDNA;VPIPITEGLDP;VPRKRDLNFEKI;YNYLEANTKVPWDDLRYL;YREKTYQQWVAGV 35 9.9 0.99755 -3.3805 9.31374 16.4925 16.6355 15.7015 14.5384 14.7286 10.4298 10.754 16.8286 15.8648 15.7828 16.0374 15.8554 15.9509 6.73145 A0A8I3P2J4 A0A8I3P2J4_CANLF ADAM metallopeptidase domain 29 ADAM29 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EADEECDC;EADEECDCGSLQ;ECDCGSLQSCSTD;EKKCNNRNDQCKQIFGEDA;ICNNKHHCHCNSFWDPPNC;PPPKREKIKKKYLLIASL;QEETVSQLESQ;SAQPSKSQQTLKSQSSVTVGPSG;VTVGPSGK;YYHGYVEGDPESL 10 13.7 1.0025 -1.4819 0 4.20688 0 0 0 7.15613 0 9.30136 7.67257 10.5523 0 10.1346 8.0022 9.48363 0 A0A8I3P2K0 A0A8I3P2K0_CANLF ADP-ribosylation factor-related protein 1 ARFRP1 Canis lupus familiaris (Dog) (Canis familiaris) "gastrulation [GO:0007369]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVPILVLANKQ;VLANKQDVE 2 7 0.99075 -0.27513 0 0 0 0 0 6.77584 0 0 0 0 0 0 0 0 0 A0A8I3P2L6 A0A8I3P2L6_CANLF Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (Aldose reductase) AKR1B1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] oxidoreductase activity [GO:0016491] AGKEYFPLDGEGNV;AGKEYFPLDGEGNVIPSDTSF;IDCAHVYQNENEVG;LFVVSKLWCTYHEKSMVKGAC;SPDRPWAKPEDP;VLCNGAKMPV 6 24.7 0.99036 -0.26639 0 0 13.3062 5.19543 0 11.5722 0 0 0 0 0 0 0 0 15.5011 A0A8I3P2L7 A0A8I3P2L7_CANLF Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) JMJD6 Canis lupus familiaris (Dog) (Canis familiaris) "cell surface receptor signaling pathway [GO:0007166]; erythrocyte development [GO:0048821]; heart development [GO:0007507]; kidney development [GO:0001822]; lung development [GO:0030324]; macrophage activation [GO:0042116]; negative regulation of protein homooligomerization [GO:0032463]; non-membrane-bounded organelle assembly [GO:0140694]; oxidative RNA demethylation [GO:0035513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; recognition of apoptotic cell [GO:0043654]; regulation of mRNA splicing, via spliceosome [GO:0048024]; retina development in camera-type eye [GO:0060041]; sprouting angiogenesis [GO:0002040]; T cell differentiation in thymus [GO:0033077]" cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904] histone H3R2 demethylase activity [GO:0033746]; histone H4R3 demethylase activity [GO:0033749]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidative RNA demethylase activity [GO:0035515]; P-TEFb complex binding [GO:0106140]; peptidyl-lysine 5-dioxygenase activity [GO:0070815]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transcription regulator activator activity [GO:0140537] SVDLQESTGIASDSSS 1 3.9 0.98697 -0.23344 0 0 0 0 0 0 0 0 0 0 0 0 8.9633 0 0 A0A8I3P2M0 A0A8I3P2M0_CANLF Uncharacterized protein CFAP144 Canis lupus familiaris (Dog) (Canis familiaris) ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] NPLRKIHTITRK 1 8.9 0.95672 0.05044 8.33204 7.68299 0 0 0 0 8.67278 7.67292 7.54821 0 0 0 0 0 0 A0A8I3P2M4 A0A8I3P2M4_CANLF Olfactory receptor OR5H11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LNPVIYSLRNKKVIDSLRKILKR;LTILIVLISYTLVL;LVLFIILKKK;TLVLFIILKKKSL;VIYSLRNKKVIDSLRKILKR 5 14.9 1.0027 -0.79064 0 0 5.83246 0 0 0 0 7.79455 5.81486 0 0 7.67108 7.62242 0 0 A0A8I3P2M7 A0A8I3P2M7_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP2 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; rhythmic process [GO:0048511] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] DEKGRQMWRKYL;ESRIRTSK;LTDCMRLFTKE;LTDYLENYGRK;PDDEKGRQMWRKYLEREDSRIGD;QIQRYAPRFVGYNQ;RFPKILVLHLK;TDCGYCSTVF;YLENYGRKGSAPQLPTQVPPTRV 9 17 1.0039 -1.0754 0 0 6.67624 0 10.2475 5.94486 9.42733 11.1864 0 0 4.14714 0 10.514 0 10.4405 A0A8I3P2N6 A0A8I3P2N6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALHNHYTQKSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;EALHNHYTQKSLSHSPG;EDGSYFLYSKL;EIISKTPGQAHQPNV;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;FLYSKLSVDKSR;FVDSKQVQTA;GPSVFIFPPKPKD;GSLTSGVHTFPSILQSSGL;GSYFLYSKL;GTYRVVSVLPIGHQD;GVHTFPSILQSSGL;HNHYTQKSLSHSPG;HYTQKSLSHSPG;IFPPKPKD;IISKTPGQA;IISKTPGQAHQPNV;KLSVDKSR;LHNHYTQKSLSHSPG;LTSGVHTFPSILQSSGL;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTQKSLSHSPG;NKALPSPIEE;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSIL;NSGSLTSGVHTFPSILQSSG;NSGSLTSGVHTFPSILQSSGL;PENPEVQIS;PSILQSSGL;QKSLSHSPG;QLVESGGDLVKPG;QSSGLYSLSSM;SGGDLVKPG;SGGDLVKPGG;SGSLTSGVHTFPSIL;SGSLTSGVHTFPSILQSSGL;SGVHTFPSILQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSIL;SLTSGVHTFPSILQSSG;SLTSGVHTFPSILQSSGL;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TFPSILQSSGL;TPPQLDEDGSYFL;TQKSLSHSPG;TSGVHTFPSIL;TSGVHTFPSILQSSGL;TYRVVSVL;TYRVVSVLPIG;TYRVVSVLPIGHQD;VESGGDLVKPG;VESGGDLVKPGG;VHTFPSILQSSGL;VMHEALHNHYTQKSLSHSPG;VQLVESGGDLVKPG;VRQAPGKGLQ;VTVPSSRWPSET;VTVSSASTTA;VTVSSASTTAPSVF;VTVSSASTTAPSVFPL;VVSVLPIGHQD;WGPWQCDNFDY;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTQKSLSHSPG 100 44.7 0 295.59 15.1313 15.1501 14.9761 12.2199 12.661 12.3262 15.8964 16.1411 15.6764 11.2933 12.4294 11.7822 15.0925 14.9095 14.8075 A0A8I3P2P8 A0A8I3P2P8_CANLF Dynein axonemal assembly factor 6 DNAAF6 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] trans-Golgi network [GO:0005802] dynein intermediate chain binding [GO:0045505]; protein-folding chaperone binding [GO:0051087] EYEVIFKQQVG;KDSSSACCE;KDSSSACCEDLVVKIKLPNTNP 3 15.1 1.0037 -1.0578 5.39852 0 0 0 0 0 0 0 6.80116 0 0 0 0 0 0 A0A8I3P2Q2 A0A8I3P2Q2_CANLF Amyloid-beta A4 protein APP Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; endocytosis [GO:0006897]; Notch signaling pathway [GO:0007219] cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; metal ion binding [GO:0046872]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102] DTEEYCMAVCGS;EDDEDGDEVEEEA;EEEEAEDDEDDE;EQKDRQHTLKH;LVPTDGNAG;SDNIDSADAEEDDSDVWWGG;VADVEEEEAEDDEDDEDGDEVEE;VEEEEAEDDEDDED;YADGSEDKVVEVAEEEEVAD 9 13.2 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 0 0 8.53881 0 0 8.71918 A0A8I3P2Q5 A0A8I3P2Q5_CANLF Glutamate ionotropic receptor delta type subunit 2 GRID2 Canis lupus familiaris (Dog) (Canis familiaris) FLGAIFDESAKKD 1 15.9 0.93912 0.0597 8.49466 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P2Q9 A0A8I3P2Q9_CANLF Coiled-coil domain containing 182 CCDC182 Canis lupus familiaris (Dog) (Canis familiaris) female gonad development [GO:0008585] LGAGRVVQGVP 1 7.2 0.99521 -0.15796 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.84185 A0A8I3P2T1 A0A8I3P2T1_CANLF VPS37A subunit of ESCRT-I VPS37A Canis lupus familiaris (Dog) (Canis familiaris) catabolic process [GO:0009056]; protein transport [GO:0015031] ESCRT I complex [GO:0000813]; late endosome membrane [GO:0031902] AEEESDNIAEDF;KLQQAITVHSQ 2 6.2 0.9957 -0.56724 0 0 0 0 0 0 0 0 0 9.86884 0 0 0 0 0 A0A8I3P2T9 A0A8I3P2T9_CANLF Transporter SLC6A14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] FVITPLLLIAILI;LVCVTQAGIYWV 2 3.9 0.99176 -0.13658 0 0 0 6.75275 0 0 0 11.1198 0 0 0 0 0 0 0 A0A8I3P2U0 A0A8I3P2U0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SLQMSSVETPHVET 1 11.8 0.94359 0.061136 0 0 0 0 0 0 0 0 0 0 0 0 0 4.72132 0 A0A8I3P2U2 A0A8I3P2U2_CANLF HtrA serine peptidase 2 HTRA2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508] mitochondrion [GO:0005739] serine-type endopeptidase activity [GO:0004252] APAVVYIEILGRHPFSGREVPISN;PSSPRSQYNFIAD;TLYVTPEV 3 12.5 0.98744 -0.40382 0 0 0 7.0365 0 0 0 9.02744 0 0 0 0 0 0 0 A0A8I3P2U8 A0A8I3P2U8_CANLF Ran GTPase activating protein 1 CHADL Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] ALTTLNLAHN;DDEGEDDEEEEEEEEEEEEGEE;DEEEEEEEEEEEEPQ;EDDEEEEEEEEEEEEGEEEEEEE;EDEEEEEEEEEEEEP;EEEDEEEEEEEEEEEEPQ;EEEEDEEEEEEEEEEEEP;EEEEEDEEEEEEEEEEEEP;EGPARASDRPPG;GGSLQHLFLNSSGL;GLASLIYLYLSDNR;GSLQHLFLNSSGL;PGCVCASESRHSGCE;PSPEKLLRLGPKSSVL;RCPPTCVCDN;SAFLKVSSV;TAEDAKDVI 17 11.5 1.004 -1.99 0 11.3065 10.0272 9.78485 9.5498 0 5.86723 10.7413 0 10.7026 4.88728 11.4255 10.8351 8.28545 0 A0A8I3P2V7 A0A8I3P2V7_CANLF Phosphorylated CTD interacting factor 1 PCIF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727] intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654] mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047] DTPPAENK;KLRQHYRELCQQREGIEPPRESFNR;LGQHDVISDPLGLNAT;LPSNCEPVVSPSMFREIMNDIPIRL;SSPSIPGTPTLKMWGTSPEDKQQ;VEAPEVEPRLVYCYP;VLGQHDVISDPLGLN 7 16.1 0.98977 -0.52737 8.15462 0 0 0 0 11.7271 0 0 0 9.23915 5.66428 8.39266 0 0 11.3176 A0A8I3P2X9 A0A8I3P2X9_CANLF Neuritin 1 NRN1 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection extension [GO:1990138] membrane [GO:0016020] VFKGFSDCLLKLGDS 1 10.6 0.95117 0.053899 0 0 0 0 0 0 0 7.99333 0 0 0 0 0 0 0 A0A8I3P2Y0 A0A8I3P2Y0_CANLF Inhibin beta A chain (Activin beta-A chain) INHBA Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; endodermal cell differentiation [GO:0035987]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of hair follicle development [GO:0051799]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; roof of mouth development [GO:0060021]; striatal medium spiny neuron differentiation [GO:0021773]; transcription by RNA polymerase II [GO:0006366] activin A complex [GO:0043509]; inhibin A complex [GO:0043512]; perinuclear region of cytoplasm [GO:0048471] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]; type II activin receptor binding [GO:0070699] KANRTRTKVTIRLLQKHPQGSLDA;LVLLGKKKKK;VNICCKKQ 3 9.9 1.0037 -1.6745 0 5.85935 0 7.43045 0 0 0 0 0 5.08049 0 0 0 0 0 A0A8I3P2Y8 A0A8I3P2Y8_CANLF Cyclin dependent kinase 2 interacting protein CINP Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] preribosome binding [GO:1990275] EELQTTYD;YHYRDGRHRPPLFHTWPTAYFYE 2 14.6 0.98735 -0.46374 0 0 0 0 0 0 0 0 0 0 0 0 0 9.02989 0 A0A8I3P2Z0 A0A8I3P2Z0_CANLF Inactive rhomboid protein (iRhom) (Rhomboid family member) (Rhomboid veinlet-like protein) RHBDF2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein secretion [GO:0050709]; protein localization to plasma membrane [GO:0072659]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] ATYRDTHAP;DTGPPMDKSDLGQ;ELFQSWQLLERP;FAGLFASL;LATFVKWQDDTG;STVQRQLESFDSHRPYFTYW;YMKSVSLQE 7 8.7 0.86685 0.14451 9.46761 14.9586 11.4597 6.95861 0 0 0 9.68654 0 0 0 11.4707 0 0 0 A0A8I3P2Z2 A0A8I3P2Z2_CANLF Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) LOC120285835 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468]; regulation of primary metabolic process [GO:0080090]; response to endoplasmic reticulum stress [GO:0034976] cilium [GO:0005929]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CDHPETPFLLS;EIKALQEIEDNQ;ESGRPEKDFICKAIAG;IVALKKVALRRL;LGTQTWKEYYLCR;TEIWSSPLQ 6 15.4 0.98481 0.035491 0 0 7.93221 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P2Z3 A0A8I3P2Z3_CANLF Circadian associated repressor of transcription CIART Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] E-box binding [GO:0070888] LLKPKQPWHLTEWP;PLSSPGTISFSHGPLGTGAS 2 8.8 0.91478 0.11163 0 0 0 0 0 0 0 0 11.2247 0 8.79786 0 0 0 0 A0A8I3P2Z4 A0A8I3P2Z4_CANLF Cyclin-H CCNH Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; regulation of transcription by RNA polymerase II [GO:0006357] transcription factor TFIIK complex [GO:0070985] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] KPSQPMTVLPNDPVFLEPHE;TVLPNDPVFLE 2 6.7 0.99463 -0.17313 5.6684 0 0 0 0 0 0 9.42689 0 0 0 0 0 0 0 A0A8I3P2Z8 A0A8I3P2Z8_CANLF Uncharacterized protein LRRC10 Canis lupus familiaris (Dog) (Canis familiaris) EGEAPVLPS;PGRLQRLRELRT 2 7.5 0.99246 -0.28276 0 7.05658 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P313 A0A8I3P313_CANLF P2X purinoceptor P2RX1 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; insemination [GO:0007320]; platelet activation [GO:0030168]; positive regulation of monoatomic ion transport [GO:0043270]; regulation of calcium ion transport [GO:0051924]; regulation of vascular associated smooth muscle contraction [GO:0003056]; response to ATP [GO:0033198]; serotonin secretion by platelet [GO:0002554] external side of plasma membrane [GO:0009897]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614] NCDLDWHV;VLVRNKKVGVVFRLIQFVVLVYV 2 7.8 0.98767 -0.46422 0 0 0 0 4.988 0 0 0 0 0 0 0 0 0 0 A0A8I3P319 A0A8I3P319_CANLF TPX2 microtubule nucleation factor TPX2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; regulation of mitotic spindle organization [GO:0060236] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle pole [GO:0000922] QVKTSYSYDAPTDFIN 1 2.2 0.93436 0.065648 0 0 0 0 0 0 0 0 9.47689 0 0 0 0 0 0 A0A8I3P321 A0A8I3P321_CANLF DENN domain containing 10 DENND10 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641] late endosome [GO:0005770] guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267] AAAEAVDTQLML;FVDLEVSNRSDLYDVF 2 7.8 0.98554 -0.44968 0 0 0 0 0 0 0 0 12.8166 12.775 12.8855 0 10.121 0 0 A0A8I3P340 A0A8I3P340_CANLF DENN domain containing 4B DENND4B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] EAGSSQTEPYLERHSPTRPLQ;GGHPLELSAGLLGGTQPVICYR;ITDVCLVLPSKGE;LLGHCYGLWFLCLPAYVRSAPSRVQ;PITDMAVIARA;QCPYIPLCPLV;QIPQRVVW;RGRDKPPL;TDVCLVLPSKGEGTP;VGIHSSYFDL 10 9 1.0024 -1.8716 0 9.40154 0 7.91474 9.50585 0 0 11.0787 0 9.10973 0 11.3279 11.1189 0 0 A0A8I3P347 A0A8I3P347_CANLF MOB kinase activator 3C MOB3C Canis lupus familiaris (Dog) (Canis familiaris) ALCLKQVF 1 3.7 0.9891 -0.26277 0 0 0 0 0 0 0 0 0 11.2213 0 0 0 0 0 A0A8I3P350 A0A8I3P350_CANLF Vitrin VIT Canis lupus familiaris (Dog) (Canis familiaris) DAGFVPKEELSTQSLE;IEGATENEKQYVT 2 4.6 0.92029 0.11224 0 0 0 0 0 0 0 5.72787 12.4554 0 0 0 0 0 0 A0A8I3P352 A0A8I3P352_CANLF Nucleoporin 43 NUP43 Canis lupus familiaris (Dog) (Canis familiaris) LVCGTDSEAI 1 3.5 0.99928 -0.61146 0 0 0 0 0 0 10.3429 0 0 0 0 0 0 0 0 A0A8I3P357 A0A8I3P357_CANLF Cysteine and tyrosine-rich protein 1 CYYR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEDCLAQCGKDCRSYCCDG;CGKDCRSYCCDGTTPYC;GVLRVQKERENFK 3 20.9 0.99353 -0.16979 0 9.00011 0 0 0 4.75425 0 0 0 5.44655 0 0 0 0 0 A0A8I3P360 A0A8I3P360_CANLF Centrosomal protein 41 CEP41 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; protein transport [GO:0015031] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737] CPFLLLDVRDRDSYQ;LSGGRLSQANASGR;SKAPGTRSGQTLPA 3 14.3 0.93902 0.075435 0 0 0 0 0 0 0 0 0 0 0 0 12.8552 0 0 A0A8I3P384 A0A8I3P384_CANLF Olfactory receptor OR4C12C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVDSLHEKKV;PMYFFLTHLS 2 6.5 0.98738 -0.50149 0 9.52042 0 0 0 0 0 8.08247 0 0 0 0 0 0 0 A0A8I3P386 A0A8I3P386_CANLF Transcription factor E2F8 E2F8 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; fibroblast proliferation [GO:0048144]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; positive regulation of DNA endoreduplication [GO:0032877]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sprouting angiogenesis [GO:0002040]; trophoblast giant cell differentiation [GO:0060707] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVNFPSFHVTP;EAKDCLHEHLSG;KPKEISQGEPWTP;LEAKHPSKDNCAKNLFSTRGKPN;NTGQNGHPDMCFVE;SELTAVNFPSFHV 6 8.9 1.0014 -0.91912 10.5377 0 0 0 0 6.70998 0 0 0 8.97611 0 0 0 14.1505 0 A0A8I3P389 A0A8I3P389_CANLF Dynein axonemal intermediate chain 2 DNAI2 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158] external side of plasma membrane [GO:0009897]; microtubule [GO:0005874]; outer dynein arm [GO:0036157]; sperm flagellum [GO:0036126] microtubule motor activity [GO:0003777] QEYFDDEDAVEV 1 2 0.94571 0.05044 11.1443 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P392 A0A8I3P392_CANLF CD1a8 protein CD1A8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PEAWLSAGPSPGPG;PSPGPGRLQLVCHVSGFYPK;PYSVGLVFLVVI;VGLVFLVVIVPLVLLAGLAWWL 4 16.3 0.98529 -0.23559 10.0044 0 0 0 0 0 0 0 0 0 0 0 0 0 4.41 A0A8I3P395 A0A8I3P395_CANLF Glial cells missing transcription factor 2 GCM2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874]; intracellular phosphate ion homeostasis [GO:0030643]; parathyroid gland development [GO:0060017]; transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific double-stranded DNA binding [GO:1990837]" ACPNCHSTL;DIMPPFQKYPN;DKARLKQQKKACPNCHSTLEL 3 6.3 1.0027 -0.72125 0 0 0 0 0 0 7.00473 0 0 0 0 0 9.41382 0 9.62741 A0A8I3P3A7 A0A8I3P3A7_CANLF Paralemmin-1 (Paralemmin) PALM Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] apicolateral plasma membrane [GO:0016327]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; lateral plasma membrane [GO:0016328]; synapse [GO:0045202] EDETKVVHAVDGTAENG;ELVVIEDAAEPKEPAPPNGSAAE;SLGPCPGG 3 9.9 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 8.96806 0 0 0 0 A0A8I3P3A8 A0A8I3P3A8_CANLF Small cysteine and glycine repeat containing 6 SCYGR6 Canis lupus familiaris (Dog) (Canis familiaris) CCCRRSCGCSSCGCGCG;CCGCGGCGGCSSGCGGCSSGCG;CCGCGGCGGCSSGCGGCSSGCGGCG;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSA;CCPCCCGCCGGCCSAPVVC;CCPCCCGCCGGCCSAPVVCCC;CCSSCCPCCC;CCSSCCPCCCGCCG;CCSSCCPCCCGCCGG;CCSSCCPCCCGCCGGC;CCSSCCPCCCGCCGGCCS;CCSSCCPCCCGCCGGCCSA;CCSSCCPCCCGCCGGCCSAP;CCSSCCPCCCGCCGGCCSAPV;CGCSSCGCGCGKCCQ;CGGCCSAPVVCCCRRSCGCSS;CGGCGGCGG;CGGCGSCGGCGGCGGSC;CGGCSSGCGGCGSCGGCGGCGGSCT;CPCCCGCCGGCC;CPCCCGCCGGCCSAPVVC;CRCYRVGCCSSCCPCCCGCCGGC;CSSCCPCCCGCCGGCCSA;CSSCCPCCCGCCGGCCSAP;CSSCCPCCCGCCGGCCSAPVVCC;CSSGCGGCSSGCGGCG;CSSGCGGCSSGCGGCGS;CSSGCGGCSSGCGGCGSCG;CSSGCGGCSSGCGGCGSCGGCG;CSSGCGGCSSGCGGCGSCGGCGGC;CTTCRCYRVGCCSSCCPCCCG;CYRVGCCSSCCPCCCGC;CYRVGCCSSCCPCCCGCC;CYRVGCCSSCCPCCCGCCG;CYRVGCCSSCCPCCCGCCGGCC;CYRVGCCSSCCPCCCGCCGGCCSA;GCCGCGGCGGCSSGCGGCSSGC;GCCGGCCS;GCCSSCCPCCCGC;GCCSSCCPCCCGCCGGC;GCCSSCCPCCCGCCGGCC;GCCSSCCPCCCGCCGGCCSA;GCCSSCCPCCCGCCGGCCSAPV;GCCSSCCPCCCGCCGGCCSAPVVC;GCGGCGGCSSGCGGCSSGCGGC;GCGGCGSCGGCGGCGG;GCGGCGSCGGCGGCGGSCT;GCGGCSSGCGGCSSGCGGC;GCSSCGCGCGKCCQQKCCC;GCSSGCGG;GCSSGCGGCGSCGGCGGCGG;GCSSGCGGCSSGCGGCGS;GGCGSCGGCGGCGGSCTTCRCY;GGCSSGCGGCGSCGGCGGCGG;GGCSSGCGGCGSCGGCGGCGGSCTT;GGCSSGCGGCSSGCGGCGSCGGCGG;GSCTTCRCYRVGCCSSCCPCCCG;GSCTTCRCYRVGCCSSCCPCCCGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCS;MGCCGCGGCGGCSSGCGGCSSG;PCCCGCCGGCC;PCCCGCCGGCCSAPVVCC;RCYRVGCCSSCCPCCCGCCGG;RVGCCSSCCPCCCGCCGGCC;RVGCCSSCCPCCCGCCGGCCS;RVGCCSSCCPCCCGCCGGCCSAP;SCCPCCCGCC;SCCPCCCGCCGGCCSAP;SCCPCCCGCCGGCCSAPVVCCC;SCCPCCCGCCGGCCSAPVVCCCR;SCGCSSCGCGCGKCC;SGCGGCSSGCGGCGSCGG;SGCGGCSSGCGGCGSCGGCGGCGG;SSCCPCCCGCC;SSCCPCCCGCCG;SSCCPCCCGCCGG;SSCCPCCCGCCGGC;SSCCPCCCGCCGGCCSA;SSCCPCCCGCCGGCCSAPV;SSCCPCCCGCCGGCCSAPVV;SSCCPCCCGCCGGCCSAPVVCCC;SSGCGGCGSCGGCGGCG;SSGCGGCGSCGGCGGCGG;SSGCGGCSSGCGGCGSCGGCG;SSGCGGCSSGCGGCGSCGGCGG;SSGCGGCSSGCGGCGSCGGCGGC;SSGCGGCSSGCGGCGSCGGCGGCGG;TCRCYRVGCCSSCCPCCCGCCG;VGCCSSCC;VGCCSSCCPC;VGCCSSCCPCC;VGCCSSCCPCCC;VGCCSSCCPCCCGC;VGCCSSCCPCCCGCC;VGCCSSCCPCCCGCCGG;VGCCSSCCPCCCGCCGGC;VGCCSSCCPCCCGCCGGCCSA;VGCCSSCCPCCCGCCGGCCSAPV;VGCCSSCCPCCCGCCGGCCSAPVV;YRVGCCSSCCPCCCGCC;YRVGCCSSCCPCCCGCCGGCCS;YRVGCCSSCCPCCCGCCGGCCSAP 109 94.1 0.32857 0.61167 9.35149 8.89842 9.28408 8.9655 9.58885 8.956 11.6089 9.29625 6.30117 6.25961 9.15997 9.45502 7.56171 10.6738 11.5489 A0A8I3P3B5 A0A8I3P3B5_CANLF Zinc finger GRF-type containing 1 ZGRF1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YYFKNRFVYFFFFLSSFFFFFFFFC 1 5.4 0.97418 0.035538 0 0 0 0 0 0 6.16716 0 0 0 0 0 0 0 0 A0A8I3P3B7 A0A8I3P3B7_CANLF Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (Estradiol 17-beta-dehydrogenase 12) HSD17B12 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" GVGPQLGEWAVVTGSTDGIGK;VSSEIMNNVGMSYE 2 12.7 0.91239 0.11086 0 0 10.6657 0 0 0 0 7.59909 0 0 0 0 0 0 0 A0A8I3P3C5 A0A8I3P3C5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KPLHYTVIMNRHL;VLFLLMYMTIV 2 8.3 0.99245 0.0044918 6.45538 0 0 0 0 0 0 0 0 0 0 0 0 0 11.971 A0A8I3P3C7 A0A8I3P3C7_CANLF Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) USP47 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] DGEQPQIL;HAFIQPEILDGPNQYFCERCKKKWS;LEPFVGVLSSHFK 3 3.6 0.97946 0.035538 0 0 0 0 0 0 0 9.11982 0 0 0 0 0 0 0 A0A8I3P3D5 A0A8I3P3D5_CANLF acid phosphatase (EC 3.1.3.2) ACP4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of ERBB4 signaling pathway [GO:0120154]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein processing [GO:0010955]; odontogenesis [GO:0042476]; regulation of neuronal synaptic plasticity [GO:0048168] protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971] LLLLLLLL;LLLLLLLLP;LLLLLLLP;PPYAACLG;PVGPLLLLLLLLPP;TPAATVVPLLAGAVAVLAALSMVL;VGPLLLLLLLL;VGPLLLLLLLLPP;VGPLLLLLLLLPPP 9 11 1.0021 -0.65487 5.96897 0 5.48056 0 0 0 0 0 0 0 0 4.27984 11.6991 0 0 A0A8I3P3D9 A0A8I3P3D9_CANLF Inositol polyphosphate-5-phosphatase F INPP5F Canis lupus familiaris (Dog) (Canis familiaris) phosphatase activity [GO:0016791] GVIDNKVQAESDGEV;GVMKDGVNSANRYYL;KVNQYQRLSLEDLEKIEI;STDISIHAPSEIVAHGS;VGYRYNPRPRLD;VIDNKVQAESDGEVSSENDSYHSDE;VSNEETQSESTEQTP 7 9.6 0.99132 -0.30033 10.0098 0 0 0 0 0 6.50887 10.0705 0 0 11.8946 0 0 0 0 A0A8I3P3F3 A0A8I3P3F3_CANLF "Cofilin-1 (Cofilin, non-muscle isoform)" CFL1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament fragmentation [GO:0030043]; actin filament severing [GO:0051014]; mitotic cytokinesis [GO:0000281] actin cortical patch [GO:0030479]; lamellipodium membrane [GO:0031258]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015] ASGVAVSDGVIKVFNDMKV;SAVISLEGKPL 2 18.1 0 6.8856 0 0 0 0 0 0 9.83007 0 11.4135 0 0 0 0 0 0 A0A8I3P3F6 A0A8I3P3F6_CANLF WIZ zinc finger AKAP8L Canis lupus familiaris (Dog) (Canis familiaris) DLSAAAAAGIFWASDVEPSPLNL;GVTEWCVNGSPIETLSEWIKHR;ILKRRTQSRPG;IVRTVKPHIEL;MDLGSPPL;QEPPADLA;VGAYRSYIQ;VLHGLIRR 8 5.4 1.003 -2.5532 5.62498 0 5.99123 7.22718 0 7.98874 0 0 0 8.75642 6.90316 6.74376 10.3258 8.47917 10.5409 A0A8I3P3F8 A0A8I3P3F8_CANLF Homeobox protein Hox-D10 HOXD10 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; anterior/posterior pattern specification [GO:0009952]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; neuromuscular process [GO:0050905]; peripheral nervous system neuron development [GO:0048935]; proximal/distal pattern formation [GO:0009954]; single fertilization [GO:0007338]; skeletal muscle tissue development [GO:0007519]; spinal cord motor neuron cell fate specification [GO:0021520] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" YNNSPEGSS 1 2.2 1.0035 -0.80421 0 0 3.37309 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P3F9 A0A8I3P3F9_CANLF Cerebellar degeneration related protein 2 like CDR2L Canis lupus familiaris (Dog) (Canis familiaris) identical protein binding [GO:0042802] EEPWYDQQDLEQDLHLAAE;SPAASPGHSVRKSC 2 7.1 0.98892 -0.19893 0 0 0 0 0 0 0 0 7.97705 8.77129 0 0 0 0 0 A0A8I3P3G2 A0A8I3P3G2_CANLF t-SNARE coiled-coil homology domain-containing protein STX3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] AALPLLPFPP;IKELHDMFVDI;RGFIIIIFVIITAVS 3 6.7 0.95605 0.053874 0 0 0 0 0 0 5.18321 0 0 0 0 0 0 0 0 A0A8I3P3G9 A0A8I3P3G9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LVRAKPLLLKLLK;NMSVSTDSAVSTSQIPALEQET 2 56.5 0.91548 0.11127 0 0 0 3.66653 0 0 0 0 0 0 0 0 0 0 10.0276 A0A8I3P3H2 A0A8I3P3H2_CANLF LRRCT domain-containing protein SLITRK3 Canis lupus familiaris (Dog) (Canis familiaris) "axonogenesis [GO:0007409]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of synapse assembly [GO:0051965]; regulation of presynapse assembly [GO:1905606]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]" cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; postsynaptic membrane [GO:0045211] AAGLFAYVLRRRRKKLPFRSK;AYVLRRRRKKL;EDGGGGGG;FAYVLRRRRKK;GGGGGGSG;LDIFRNDTFLGLE;LFAYVLRRRRKKLPFR;SLGIPHLSSSKENA;TIELEVLCPE;TVNCKERGFNNI 10 8.3 1.0015 -0.70955 5.35653 9.5016 0 6.76951 0 8.51534 7.81532 13.8751 8.4312 9.34665 0 0 0 0 0 A0A8I3P3H6 A0A8I3P3H6_CANLF Sushi repeat-containing protein SRPX2 SRPX2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; synapse [GO:0045202] GTITRVTLRGPEPGSHFPEGE;SMLQQSTCGLDLRH 2 8 0.98786 -0.46041 9.43788 0 8.59167 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P3I1 A0A8I3P3I1_CANLF Sphingosine-1-phosphate receptor 2 S1PR2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; excitatory postsynaptic potential [GO:0060079]; filopodium assembly [GO:0046847]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800] plasma membrane [GO:0005886]; postsynapse [GO:0098794] G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; sphingosine-1-phosphate receptor activity [GO:0038036] PILGWNCLGHLEACSTVLPLYTKHY 1 7.1 0.9909 -0.29762 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1755 A0A8I3P3I2 A0A8I3P3I2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) RIPK2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response [GO:0031349]; regulation of apoptotic process [GO:0042981]; response to stress [GO:0006950] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ALGVNYLHNMNPPL;DIYSYAVI;LHRKTEYPDVAWPLRFR;LVVSRSQPLNSFQ 4 10.5 1.0018 -0.6631 6.54509 9.44836 0 0 7.91223 0 0 0 0 0 0 0 0 0 0 A0A8I3P3I3 A0A8I3P3I3_CANLF "BCAR3 adaptor protein, NSP family member" BCAR3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784] DHMQDRRALSLKAHQSES;LSPALVRRV 2 3.7 1.0038 -1.0602 0 0 9.43713 0 5.65864 0 0 0 0 7.98145 0 10.5021 9.4949 9.52593 9.2681 A0A8I3P3J2 A0A8I3P3J2_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FHKIRSRIVQRTPKTKKSKKFRK;IFNKEPGDS;NNKLILAISVTVVVMILIIV;VLTEVSFGTFQAWH 4 8.5 0.987 -0.23388 0 0 0 9.25986 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P3J8 A0A8I3P3J8_CANLF Chromosome 15 open reading frame 39 C15orf39 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] AVPPASVP;DFAPQTLSFPYARDDLS;GGLSSPYLRQQAAQTPYMPPVGLDT;LREWLATAGPWGRAAW;PGHSLPPS;YGLSPCLGEGAAKRPLDVDWTMVT;YPDLLGLQWRDCV 7 11 1.0039 -1.6813 0 0 0 0 9.25526 9.81796 8.49993 0 0 9.27766 8.78767 7.79954 0 0 10.9386 A0A8I3P3K0 A0A8I3P3K0_CANLF Rho GTPase activating protein 42 ARHGAP42 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] EFAPYKQQLQ;GSRRTRAICLSTGSRKPRGRYTPC;LKATYEGK;PKSPPDIDIDIE;SDSYSSSPD;SPSNGQKSLGIWATSPES;VEILIEHYEKIFHTAPDPSV;YVFKIQEVQ 8 13.8 1.0035 -2.3838 0 11.1116 9.69653 0 0 9.86281 9.56944 7.38965 14.7707 0 9.43171 0 0 0 9.90721 A0A8I3P3L4 A0A8I3P3L4_CANLF DDB1 and CUL4 associated factor 7 DCAF7 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EEYNNKVVILDVRVPCTP 1 12.7 0.97417 0.048313 0 0 0 0 0 6.21465 0 0 0 0 0 0 0 0 0 A0A8I3P3M6 A0A8I3P3M6_CANLF G protein-coupled receptor 84 GPR84 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] VVAVTGTA 1 2 0.99012 -0.26592 0 16.2073 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P3M7 A0A8I3P3M7_CANLF Alpha-L-fucosidase (EC 3.2.1.51) FUCA1 Canis lupus familiaris (Dog) (Canis familiaris) fucose metabolic process [GO:0006004]; lipid metabolic process [GO:0006629] lysosome [GO:0005764] alpha-L-fucosidase activity [GO:0004560] DTYWNSTEFLSWLYNDSPVK;GEWECPDT;NCQDKYKPESLPDHKWEMCT;PELYDLVNRYEPDLIW;PLPLPLLLLLLGAA;PPPLPLPLPLLLLL 6 18.1 0.99118 -0.54585 0 8.63905 0 8.58751 0 0 0 0 0 0 0 0 6.19989 8.52278 0 A0A8I3P3N1 A0A8I3P3N1_CANLF Leucine rich repeat containing 71 LRRC71 Canis lupus familiaris (Dog) (Canis familiaris) EERILGIFSKCLPPLSQ;EQLVAEASEVVNP;GVLETDFAELCTRS 3 7.9 0.9904 -0.21041 0 0 0 0 0 0 8.17896 0 0 0 0 0 9.07799 0 0 A0A8I3P3N5 A0A8I3P3N5_CANLF Myocyte enhancer factor 2B MEF2B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PAQSRPSP 1 2.7 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 8.37491 0 0 A0A8I3P3N6 A0A8I3P3N6_CANLF Carbonic anhydrase (EC 4.2.1.1) CA2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] GEPEELMMDNW;KSLCPCYDQ;NKEGEPEEL 3 8.8 0.98986 -0.52873 5.7389 0 0 9.18321 0 9.46575 0 0 0 0 0 0 0 4.72732 4.74642 A0A8I3P3N8 A0A8I3P3N8_CANLF Kelch domain-containing protein 10 KLHDC10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of stress-activated MAPK cascade [GO:0032874]; rescue of stalled ribosome [GO:0072344]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] GGGGGGSG;KKKIRWDPVRRRF;NPDYDESGGPDNEDYPLFRELWRY;WTAYSLNKIHAYNLE;YVFGGYNPDYDESGGPDNED 5 14.9 0.99273 -0.55422 0 0 12.9961 0 0 0 12.5185 0 0 0 7.29287 8.55861 0 0 0 A0A8I3P3N9 A0A8I3P3N9_CANLF Sodium voltage-gated channel alpha subunit 7 SCN7A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] DKNTSDIHMIDE;DLLLPLILSLPALL;EDDFRKFFQVWEQ;ENAYFDKA;EQSQKMDAALC;KEKSSGTEKN;NAIIMVLICFQAITIMIQSD;NIYMYCYFI;PGQFSRVSR;VLRIFKLVK;YRCTKTFLIWNCSPCWLKLKEFIHM 11 9 0.99672 -4.746 10.1208 0 0 3.05068 0 7.46532 0 8.1918 12.9717 0 9.81703 0 0 0 10.3335 A0A8I3P3P0 A0A8I3P3P0_CANLF TBC1 domain family member 9 TBC1D9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] GGGGGGGA;NDVKEDDD;QYFFEDITPEC;VGWGFFNV 4 3 1.0044 -1.1044 0 0 0 0 0 0 0 7.55244 0 0 0 0 0 0 0 A0A8I3P3P2 A0A8I3P3P2_CANLF Apolipoprotein B mRNA editing enzyme catalytic subunit 2 APOBEC2 Canis lupus familiaris (Dog) (Canis familiaris) cytidine to uridine editing [GO:0016554]; mRNA modification [GO:0016556]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029] cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802] PALRYNVTWYVSS 1 5.8 0.93957 0.059836 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.78784 A0A8I3P3R3 A0A8I3P3R3_CANLF Olfactory receptor LOC119864131 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSIIDGFY;SYLSIIDGFYSS 2 3.9 1.0008 -0.63439 0 0 0 0 0 0 0 0 0 0 9.84699 0 0 0 0 A0A8I3P3S4 A0A8I3P3S4_CANLF "ZFP91 zinc finger protein, atypical E3 ubiquitin ligase" ZFP91 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AEYPRRRRSSPSARPPDAP;DKSPRLPKRRKKPPI;EEEMLISEEEIPFKDD;LGTNPESLT;PSARPPDAPGQQSQA 5 11.6 1.0024 -0.90196 0 0 0 0 6.86071 0 0 0 8.60084 0 0 0 13.7163 0 0 A0A8I3P3T1 A0A8I3P3T1_CANLF CAS1 domain containing 1 CASD1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity [GO:0047186] DLESGEEKKNI;ENRKMITNEKIDAYNEAAVSI;MHIRVLVAAYLFQT;SQGAFEKIFSLWP;VPLVTVWFMVIY 5 7.6 1.0021 -0.90364 0 0 9.57098 8.46119 0 0 0 0 11.0688 0 12.1963 10.0197 0 0 0 A0A8I3P3T6 A0A8I3P3T6_CANLF RBBP8 N-terminal like RBBP8NL Canis lupus familiaris (Dog) (Canis familiaris) AAPSGGGH;IRPALPGCLSLPGTS;NETLKEEMK 3 4.5 1.0032 -1.5545 0 0 0 0 0 0 0 13.5682 0 8.94582 0 0 0 0 0 A0A8I3P3T7 A0A8I3P3T7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] AEAVKGRF;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLE 26 37.5 0.91781 0.11382 0 0 0 0 0 0 0 0 0 7.87289 0 7.67377 0 0 0 A0A8I3P3U7 A0A8I3P3U7_CANLF Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; exocytosis [GO:0006887]; vesicle fusion [GO:0006906] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuron projection [GO:0043005]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658] SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149] DKVVETQAQVDELKGIMVRNID;KNLKLTIIIIIVSIVFIYIIV 2 24 0.93094 0.094489 0 0 6.32726 0 0 0 0 0 0 0 0 6.34038 0 0 0 A0A8I3P3V2 A0A8I3P3V2_CANLF "Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)" HMGCL Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759]; peroxisome [GO:0005777] hydroxymethylglutaryl-CoA lyase activity [GO:0004419]; metal ion binding [GO:0046872] TEDLVYML;VGTPGVMKDMLS 2 7.9 1.0019 -1.4192 0 0 0 0 0 0 0 7.85343 0 0 0 0 0 0 0 A0A8I3P3V5 A0A8I3P3V5_CANLF Transmembrane protein 139 TMEM139 Canis lupus familiaris (Dog) (Canis familiaris) STVPDLQS 1 3.9 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 6.8674 0 0 0 0 A0A8I3P3W7 A0A8I3P3W7_CANLF Kallikrein related peptidase 12 KLK12 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] VTGLSQPATE 1 7.8 0 1.4182 0 0 0 0 0 0 0 0 0 0 8.67048 0 0 0 0 A0A8I3P3X2 A0A8I3P3X2_CANLF Gamma-aminobutyric acid type A receptor subunit delta GABRD Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] axon [GO:0030424]; chloride channel complex [GO:0034707]; dendrite [GO:0030425]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] LVEYAFAHFNADYRKKQKA 1 4.2 0.99263 -0.16932 0 0 0 0 0 0 0 0 0 0 0 0 9.18582 0 0 A0A8I3P3Y2 A0A8I3P3Y2_CANLF Formin like 3 FMNL3 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] actin filament binding [GO:0051015]; small GTPase binding [GO:0031267] ALVLSSMNLPP;DENKGLDV;EFLQKSRHTESEK;LSAIRIKKPIKTK;NFKEVCKELHRFEKLMEYF;TEAEVKLLRQYE;VLVDYLSFAQCSVMYSTL;VLVDYLSFAQCSVMYSTLPG 8 9.7 1.0041 -1.0805 0 8.06781 0 0 0 4.64553 10.5384 0 13.5349 0 10.0279 0 0 0 0 A0A8I3P400 A0A8I3P400_CANLF Peroxisomal biogenesis factor 5 like PEX5L Canis lupus familiaris (Dog) (Canis familiaris) "protein import into peroxisome matrix, docking [GO:0016560]" cytosol [GO:0005829]; peroxisomal membrane [GO:0005778] peroxisome matrix targeting signal-1 binding [GO:0005052] AASDTEFWDKM;EKGYYFHTENPFK;TSNTAVLTTGLDLLDLSEPV 3 7.8 0.9964 -0.099561 0 0 8.98063 0 0 9.47277 0 0 0 9.06366 0 0 8.70193 0 0 A0A8I3P405 A0A8I3P405_CANLF TNF receptor superfamily member 14 TNFRSF14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ELPGPPRAEWGSSPGAL 1 4.5 0.99142 -0.22174 0 0 0 0 9.40909 0 0 0 0 0 0 0 0 0 0 A0A8I3P406 A0A8I3P406_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" SLC25A31 Canis lupus familiaris (Dog) (Canis familiaris) male meiosis I [GO:0007141]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; regulation of mitochondrial membrane permeability [GO:0046902]; spermatogenesis [GO:0007283] mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757] ATP:ADP antiporter activity [GO:0005471] IPREQGFFSYWRGNLAN;VERQYKGTLDC 2 8.7 0.98531 -0.24111 0 0 0 0 0 0 7.48261 0 0 0 0 0 0 0 0 A0A8I3P434 A0A8I3P434_CANLF Mitochondrial ribosome associated GTPase 2 MTG2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]; ribosome biogenesis [GO:0042254] mitochondrial inner membrane [GO:0005743]; mitochondrial ribosome [GO:0005761] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287] RLGPSTVI 1 2.1 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.90773 A0A8I3P439 A0A8I3P439_CANLF Potassium voltage-gated channel modifier subfamily S member 3 KCNS3 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] NELFIDSCC;RYVLNFYYTGKLHVMEEL;VGGFKQSVDQSTLL 3 8.4 0.98785 -0.22477 0 0 8.32301 0 0 0 11.5602 0 0 0 0 0 0 0 0 A0A8I3P441 A0A8I3P441_CANLF Epsilon-sarcoglycan SGCE Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] GVEKRNMQTPEEQMKRPFIHVFLN;YIQRTPYSDGVLYGSPTAENVG 2 12.4 0.98789 -0.22567 0 10.6624 0 0 0 0 0 0 0 0 0 0 0 0 7.2635 A0A8I3P443 A0A8I3P443_CANLF N-acetyltransferase 9 (putative) NAT9 Canis lupus familiaris (Dog) (Canis familiaris) N-acetyltransferase activity [GO:0008080] IVLLYHEWMKSEE;NEPSIRMFQK 2 11.3 0.98655 -0.23477 0 0 0 0 0 0 0 0 0 0 0 0 6.8976 0 0 A0A8I3P446 A0A8I3P446_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCTFGDML 1 5.6 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 7.3651 0 0 0 0 0 A0A8I3P449 A0A8I3P449_CANLF Small integral membrane protein 22 SMIM22 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet formation [GO:0140042]; positive regulation of cell migration [GO:0030335]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127] membrane [GO:0016020] EVLGKLRSHTLFQSKWD 1 18.7 0.97948 0.046227 0 0 0 0 0 0 0 0 9.15843 0 0 0 0 0 0 A0A8I3P454 A0A8I3P454_CANLF A-kinase anchoring protein 1 AKAP1 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915] mitochondrion [GO:0005739] protein kinase A regulatory subunit binding [GO:0034237]; RNA binding [GO:0003723] EAVEQDEKIEQAA;EDDELLAPR;EIRYVDYGGYK;GAEVLLDSVMPLS;LAVLGWWWFFSRKK;SAHHISLAPSPSP;TELMEDDELL;VLGWWWFFS;VSKPPMEPP 9 9.8 1.0021 -2.6072 0 0 0 10.151 0 3.73227 0 9.23153 10.1053 9.2436 0 2.4872 0 0 9.26695 A0A8I3P457 A0A8I3P457_CANLF Uncharacterized protein LOC100855640 Canis lupus familiaris (Dog) (Canis familiaris) ERK1 and ERK2 cascade [GO:0070371]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of cytokine production [GO:0001818]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of regulatory T cell differentiation [GO:0045591] cell surface [GO:0009986]; membrane [GO:0016020] DNGIYHCYFQEGR;DTAHPELFLTED;FTGARGVTVPEGGLI 3 7.6 0.98949 -0.21465 0 0 0 10.1553 0 0 0 0 0 7.32472 0 10.0606 0 0 0 A0A8I3P462 A0A8I3P462_CANLF Neuralized E3 ubiquitin protein ligase 2 NEURL2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630] LLVEPYLCIEQFRIPRDRLVGR;LVSLGHTWVFAITRHHN 2 13.7 0.99303 -0.17477 7.32742 0 0 0 10.7288 0 0 0 0 0 0 0 0 0 0 A0A8I3P463 A0A8I3P463_CANLF Caspase 2 CASP2 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein processing [GO:0016485]" cytoplasm [GO:0005737]; endopeptidase complex [GO:1905369]; nucleus [GO:0005634] cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904] EGYAPGTE;KKNRVVLAKQLLLSELLEHLLE;QEMKEKLQN 3 8.6 1.003 -1.3792 0 0 0 6.04669 0 0 0 9.23043 0 0 0 0 0 0 0 A0A8I3P464 A0A8I3P464_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G4F Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; cellular response to antibiotic [GO:0071236]; cellular response to organic cyclic compound [GO:0071407]; phospholipid catabolic process [GO:0009395]; prostaglandin biosynthetic process [GO:0001516] cytosol [GO:0005829]; ruffle membrane [GO:0032587]; vesicle [GO:0031982] calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; lysophospholipase activity [GO:0004622] TLGQEEQRSVALGEDQE;WKATHPDAFPNQ 2 3.5 0.93459 0.096667 0 0 0 0 0 0 0 0 9.19168 0 0 0 0 10.1823 0 A0A8I3P468 A0A8I3P468_CANLF Histone deacetylase 3 (HD3) (EC 3.5.1.98) HDAC3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to fluid shear stress [GO:0071498]; circadian regulation of gene expression [GO:0032922]; cornified envelope assembly [GO:1903575]; DNA repair-dependent chromatin remodeling [GO:0140861]; establishment of mitotic spindle orientation [GO:0000132]; establishment of skin barrier [GO:0061436]; in utero embryonic development [GO:0001701]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of mitotic cell cycle [GO:0007346]; regulation of multicellular organism growth [GO:0040014]; regulation of protein stability [GO:0031647]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; transcription repressor complex [GO:0017053] chromatin DNA binding [GO:0031490]; cyclin binding [GO:0030332]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; NF-kappaB binding [GO:0051059]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222] IVIGILELLKYHPRVLYID;VQEAFYLTDRVM 2 7.2 0.99001 -0.26346 0 0 0 0 0 0 0 0 0 0 5.21343 0 0 0 0 A0A8I3P470 A0A8I3P470_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DSPAAAWLCPGIHTARGQP 1 27.1 0.94995 0.049735 0 9.07903 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P472 A0A8I3P472_CANLF Multidrug and toxin extrusion protein ALDH3A2 Canis lupus familiaris (Dog) (Canis familiaris) xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] membrane [GO:0016020] antiporter activity [GO:0015297]; xenobiotic transmembrane transporter activity [GO:0042910] ESQTLQLMRFCPQLR;NLKRVGIILQRGILI 2 6 0.95 0.053889 0 0 0 0 0 0 0 0 0 0 0 8.16461 0 0 0 A0A8I3P482 A0A8I3P482_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EDPQQQTVGE;VIRAILIFNNLGKQWLSTFYL 2 38.3 0.98311 -0.25559 0 0 0 0 0 7.1636 0 0 0 0 0 0 0 0 0 A0A8I3P491 A0A8I3P491_CANLF Zinc finger protein 385A ZNF385A Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AAPHHAAP;DGSGRGLPAVPAPRPGRASPP;PPLAPPGP;TPSPPRATPHLQPGPRP;VPAPRPGRASPPGTAH 5 13.3 1.0043 -1.1044 0 10.6461 0 0 0 0 11.188 10.9262 10.937 0 11.2921 11.2189 0 11.0026 10.8741 A0A8I3P492 A0A8I3P492_CANLF Transmembrane protein 80 TMEM80 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; membrane [GO:0016020] CGSASGKA;EVPLAISL 2 7.3 1.0032 -2.2088 0 2.55927 0 0 8.30838 6.62863 0 0 0 0 0 0 0 0 0 A0A8I3P497 A0A8I3P497_CANLF Lysozyme g-like protein (EC 3.2.1.-) LYG1 Canis lupus familiaris (Dog) (Canis familiaris) peptidoglycan catabolic process [GO:0009253] lysozyme activity [GO:0003796] KRHGLNYCGVRASERLAEIDMP;VGNTGNGI 2 15.2 0.98995 -0.2011 0 0 0 0 7.73268 7.95053 0 0 0 0 0 0 0 0 0 A0A8I3P4A4 A0A8I3P4A4_CANLF Maturin MTURN Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of megakaryocyte differentiation [GO:0045654]; regulation of signaling [GO:0023051] cytoplasm [GO:0005737] VAEKWCSNT 1 6.9 0.99 -0.26166 0 0 0 0 0 10.5914 0 0 0 0 0 0 0 0 0 A0A8I3P4C7 A0A8I3P4C7_CANLF THAP domain-containing protein 1 THAP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; endothelial cell proliferation [GO:0001935]; regulation of mitotic cell cycle [GO:0007346] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" LLAVPSPP 1 2.8 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 3.86126 0 0 0 0 A0A8I3P4D3 A0A8I3P4D3_CANLF BCL6B transcription repressor BCL6B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AGSLAGERNSGQLCPQAR;EAGGFAPLLDFMYTSRL;PPGSEFFSCQNCEA;SPATAPAVLAAATYLQMEHV 4 14.5 0.98804 -0.47732 0 11.6472 0 0 0 0 9.71744 0 8.1498 0 0 0 0 0 0 A0A8I3P4D4 A0A8I3P4D4_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM27 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; protein K63-linked ubiquitination [GO:0070534] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] IFAQKCLFLTE 1 3.1 0.98212 -0.24839 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.49757 A0A8I3P4E7 A0A8I3P4E7_CANLF DnaJ homolog subfamily C member 2 DNAJC2 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' cotranslational protein folding [GO:0051083]; chromatin organization [GO:0006325]; regulation of translational fidelity [GO:0006450] cytosol [GO:0005829] Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022] DLQLLIKAV;PDKRKAAGEPIKEGDNDYFT;VKRRAFNSVDPTFDNSVPSKS 3 8.8 1.0017 -0.99511 0 0 0 5.27776 0 0 0 6.90713 0 0 0 0 0 0 11.0791 A0A8I3P4G1 A0A8I3P4G1_CANLF "alpha-1,2-Mannosidase (EC 3.2.1.-)" EDEM2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380] endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020] "calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]" AIRNYTRFDDWYL 1 2.4 0.93876 0.059848 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3404 0 A0A8I3P4G5 A0A8I3P4G5_CANLF Cytochrome P450 family 7 subfamily B member 1 CYP7B1 Canis lupus familiaris (Dog) (Canis familiaris) organic hydroxy compound metabolic process [GO:1901615]; steroid metabolic process [GO:0008202] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" GGRGRRELGDSARGP;IELLGNIKSIRKKLIKHL;RRTRRPGEPPL;VGAHHLGF 4 7.3 1.0024 -1.1397 0 0 0 0 0 0 0 0 0 0 0 0 10.5945 3.17942 0 A0A8I3P4G8 A0A8I3P4G8_CANLF Phosphatidylinositol glycan anchor biosynthesis class U PIGU Canis lupus familiaris (Dog) (Canis familiaris) attachment of GPI anchor to protein [GO:0016255] GPI-anchor transamidase complex [GO:0042765] LLDLGVSPYSGAVFHEI;RFLRNIFVLTCIII;TVRAALFRSSL;VGQILLISDYFYAFLRRE;YAMMYVGSLV 5 16.9 0.98767 -0.40125 0 8.51979 0 0 0 10.0673 0 0 0 0 0 0 0 10.3976 0 A0A8I3P4H1 A0A8I3P4H1_CANLF Zinc finger MYM-type containing 3 ZMYM3 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EPDSIYYLCLGIQQYLLENNRMVN;ESTDKIVETIE;KVENSNTVKTPE;LVGPEDVSAEQDLPRTMRKGQ;RMSLRSSVAQRAGR;RPCSFCRRSLSDPCYY;TRNDVFYLQPER;YTKTGSPGPEL 8 8.8 1.0032 -0.78324 0 14.7845 7.00282 9.6287 0 0 0 13.5525 0 9.23575 0 5.38076 0 10.9408 7.98704 A0A8I3P4I0 A0A8I3P4I0_CANLF Small cell adhesion glycoprotein SMAGP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] IFFYLYKNKGSYVTYEPAEGEPS;REEEPRPGGRRQ 2 14 0.99053 -0.53853 0 0 0 0 7.33727 9.69471 0 0 0 7.50716 7.63488 7.29444 7.94837 0 0 A0A8I3P4I2 A0A8I3P4I2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FGGNIISFQSCMIQLFTEHFFGGS;LSNLFFGGNIISFQS 2 9.4 0.99331 -0.19125 0 0 0 0 0 0 0 6.56131 10.3081 0 0 0 0 0 0 A0A8I3P4J0 A0A8I3P4J0_CANLF Uncharacterized protein CT83 Canis lupus familiaris (Dog) (Canis familiaris) AELELFLVFK 1 8.7 0.98331 -0.25411 0 0 0 0 0 0 0 0 10.7881 0 0 0 0 0 0 A0A8I3P4J4 A0A8I3P4J4_CANLF 40S ribosomal protein S27 RPS27L Canis lupus familiaris (Dog) (Canis familiaris) "DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; translation [GO:0006412]" nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494] HEVYGYKLY;KKHKKKRLVQ 2 20.2 1.0033 -0.87477 0 0 4.65718 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P4K4 A0A8I3P4K4_CANLF Serpin family I member 2 SERPINI2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] INEDGSEAATATGMHIP;KGDGFSLI 2 6.2 1.002 -1.2679 0 0 0 0 8.60433 0 0 0 0 0 0 0 8.78447 0 0 A0A8I3P4L1 A0A8I3P4L1_CANLF Zinc finger protein 322 ZNF322 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] metal ion binding [GO:0046872] IVHQRVHTGEKPYKCLECMRSF;KPYKCLECMRSFTRSANLIRHQ;LLGMDFVAQQKMRTQ 3 11.7 0.99342 -0.16219 9.6596 0 0 0 0 0 8.54686 0 0 0 0 0 0 9.25826 0 A0A8I3P4L9 A0A8I3P4L9_CANLF Fibroblast growth factor receptor substrate 2 FRS2 Canis lupus familiaris (Dog) (Canis familiaris) "anterior/posterior axis specification, embryo [GO:0008595]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; gastrulation with mouth forming second [GO:0001702]; lens fiber cell development [GO:0070307]; lens placode formation involved in camera-type eye formation [GO:0046619]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; neuroblast proliferation [GO:0007405]; organ induction [GO:0001759]; positive regulation of MAPK cascade [GO:0043410]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ventricular septum development [GO:0003281]" adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] fibroblast growth factor receptor binding [GO:0005104]; neurotrophin TRKA receptor binding [GO:0005168]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] HNYVNTENVTVPASAHKIEYS;TVFNFDIRRPS;YHNNLDPMH 3 7.9 1.0035 -0.83587 0 0 8.36378 0 10.2287 0 0 0 0 0 0 0 0 0 0 A0A8I3P4M0 A0A8I3P4M0_CANLF Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) TCAIM Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] cytosol [GO:0005829] metal ion binding [GO:0046872] AAEIFLKSGSL;ALKILLKIF;EKFYKEPSVSSKQMVD;GDEKVCMDVFKKYISINEL;LWPCDRLDVL;VHHHWTKL 6 7.4 0.99121 -0.2063 0 7.63372 0 0 0 0 10.6231 0 0 0 0 0 0 0 0 A0A8I3P4M3 A0A8I3P4M3_CANLF Neurensin 1 NRSN1 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] growth cone [GO:0030426]; neuronal cell body [GO:0043025]; transport vesicle [GO:0030133] VGFLVPPKI 1 4.6 0.9835 -0.25653 0 0 0 0 0 0 0 0 8.98237 0 0 0 0 0 0 A0A8I3P4M5 A0A8I3P4M5_CANLF Homeobox D12 HOXD12 Canis lupus familiaris (Dog) (Canis familiaris) embryonic digit morphogenesis [GO:0042733]; pattern specification process [GO:0007389]; skeletal system development [GO:0001501] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" AALLEGTPCA;KDGPEEQAKFYAPD;KKKRVVLRE 3 12.2 0.99707 -0.59324 0 0 0 0 0 0 0 0 0 0 0 0 0 8.93083 0 A0A8I3P4N1 A0A8I3P4N1_CANLF Lck-interacting transmembrane adapter 1 LIME1 Canis lupus familiaris (Dog) (Canis familiaris) B cell receptor signaling pathway [GO:0050853]; T cell receptor signaling pathway [GO:0050852] membrane [GO:0016020] LLWLWALCTACHRYVWP 1 19.5 0.9834 0.046227 0 0 0 0 0 0 0 0 0 0 6.1861 0 0 0 0 A0A8I3P4N5 A0A8I3P4N5_CANLF Cationic amino acid transporter C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] FHIGWAPAYYA;LLSQDPVWITVVVLLLVLI;LTEEDYIKAGLNDTSSLGPLG;RFGQKLVRRLTLKKERAETAPAGRL;VGLLFLLVRLLTLR;VGLLFLLVRLLTLRA;VGLLFLLVRLLTLRARELV;VLIVRYQPERKN 8 19.6 0.98312 -0.2481 0 0 0 8.89627 0 9.33412 10.5349 11.2677 7.72055 3.86146 0 0 0 6.46271 0 A0A8I3P4N9 A0A8I3P4N9_CANLF Fasciculation and elongation protein zeta 2 FEZ2 Canis lupus familiaris (Dog) (Canis familiaris) EDLQILTKILRA;ELEFEKEVKNSFIS;NELLEEIESAIKEYSEELVQQLA;QENCNASPEAGAGP;QENCNASPEAGAGPGG 5 18.6 1.0015 -0.69742 11.214 11.3707 0 0 9.00677 8.25706 0 0 0 0 0 0 0 11.1613 7.83099 A0A8I3P4P7 A0A8I3P4P7_CANLF Maltase-glucoamylase 2 (putative) MGAM2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DINVPTCFF;ENMLQFKIFDPTNKRY;ETEHTAFRRDMNWTMWGMFAR;FAQQYLQLSFR;IDCQFMLGPAI;IIGMMEFSLF;IPYDVQHVDIDY;LENNKFQVSAYFPR;TAFRRDMNWTMWGMF;TTTPTLPDTTAP 10 5.5 0.99023 -0.26192 0 0 0 0 0 0 11.7518 0 0 0 0 0 0 0 0 A0A8I3P4P8 A0A8I3P4P8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF43 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transferase activity [GO:0016740] EGKLMQARMAGERGASAVLFD;SSGPCYSSSQPVWLCL 2 5 0.94998 0.049735 0 0 0 0 0 0 0 0 0 0 0 0 0 8.40489 0 A0A8I3P4R0 A0A8I3P4R0_CANLF Heat shock transcription factor 2 binding protein HSF2BP Canis lupus familiaris (Dog) (Canis familiaris) ESPGFIPLL;IRLKTTTRKVLLDLERKE 2 8.3 0.99291 -0.28018 0 0 0 0 0 0 0 0 0 0 0 0 7.73748 0 0 A0A8I3P4S3 A0A8I3P4S3_CANLF Prefoldin subunit 3 VBP1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017]; negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; prefoldin complex [GO:0016272] amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein binding [GO:0051082] IPEAVFVEDVDSFM;QYQKYKFMELNLAQ;YQKYKFMELNLAQKKRRLKGQ 3 18.3 0.99759 -0.097625 0 0 0 8.17468 10.1388 0 0 4.66471 0 0 0 0 0 0 0 A0A8I3P4S5 A0A8I3P4S5_CANLF Caspase 3 CASP3 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199] ELMNSVSKEDHSKRSSFVCVL 1 11.5 0.98397 -0.24437 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.36448 A0A8I3P4S6 A0A8I3P4S6_CANLF Armadillo like helical domain containing 2 ARMH2 Canis lupus familiaris (Dog) (Canis familiaris) QIHQYFAGLYRRSQKFWNVTV;YFAGLYRR 2 9.1 0.99049 -0.51057 9.83256 0 8.4121 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P4T2 A0A8I3P4T2_CANLF Mucosal vascular addressin cell adhesion molecule 1 MADCAM1 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229]; positive regulation of lymphocyte migration [GO:2000403] membrane [GO:0016020] integrin binding involved in cell-matrix adhesion [GO:0098640] LVLGLLLLALLAYRLRKR 1 4.8 0.97307 0.048313 0 0 0 0 0 9.20823 0 8.42198 0 0 0 0 0 8.82934 0 A0A8I3P4T7 A0A8I3P4T7_CANLF Arginyl aminopeptidase RNPEP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] EDFWKVKEFLQS;ELDMGAIGAVAIST;GSSGSSAAP;KQKYTLPLY;PFSHYGQALCVAL;TPYEKGFCFVSYLAHLVGD 6 12.4 1.0026 -1.4901 8.01931 9.31549 0 0 8.70408 0 0 0 0 0 9.15866 0 3.10378 0 0 A0A8I3P4U2 A0A8I3P4U2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVSSVISPKMI;PHLHSPMY 2 5.3 0.98606 -0.24596 0 0 0 0 0 0 0 0 0 0 0 0 7.72226 0 0 A0A8I3P4V1 A0A8I3P4V1_CANLF Cohesin subunit SA (SCC3 homolog) (Stromal antigen) LOC102156180 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; nucleus [GO:0005634]" AAPTLVRNWECMTAL;AFYSTHDLSGWNL;LGFQTQGAASGGLSAS;VFLFQFVYAAY;WIRLYPDMFLDNNYLKYIGWMLYDK 5 7 1.0021 -0.69132 0 0 8.35328 6.73525 7.0594 7.55374 9.8396 9.69036 10.212 0 0 0 8.09545 8.18364 8.43788 A0A8I3P4V5 A0A8I3P4V5_CANLF Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) CSRP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DKGESLGIKHEETLG;GGGGGGGE;GGGGGGGG 3 8.6 0.99103 -0.22159 0 0 0 0 0 0 0 0 0 0 0 0 0 9.25652 0 A0A8I3P4Y5 A0A8I3P4Y5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] DTAVYYCPKDTV;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLQ 26 37.7 0.99384 -0.12074 0 0 0 0 0 0 0 0 0 0 0 11.2266 0 0 0 A0A8I3P4Z3 A0A8I3P4Z3_CANLF WW domain binding protein 1 WBP1 Canis lupus familiaris (Dog) (Canis familiaris) CCGETGCCTYYY;ESGHCCGETGCCTYYYELWWF;HCCGETGCC;QPYLCESGHCCGETG 4 9.7 1.0019 -1.3112 0 2.70323 0 6.20945 0 7.2948 11.2099 0 0 0 0 0 0 0 6.25584 A0A8I3P4Z6 A0A8I3P4Z6_CANLF Pannexin PANX1 PANX Canis lupus familiaris (Dog) (Canis familiaris) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732] gap junction [GO:0005921]; plasma membrane [GO:0005886] channel activity [GO:0015267] VGVFQLLSLINLVVYVL;VLRVYELLPTFD 2 7.5 0.93324 0.096667 0 0 0 0 0 9.63503 0 0 0 0 0 0 0 0 9.31463 A0A8I3P500 A0A8I3P500_CANLF Solute carrier family 39 member 1 SLC39A1 Canis lupus familiaris (Dog) (Canis familiaris) embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173] plasma membrane [GO:0005886] zinc ion transmembrane transporter activity [GO:0005385] ALAALHVTLQFPL;LKVILLLAGF;SEQRILKVILLLAGFAL 3 9.3 1.0039 -0.82592 0 0 0 7.98601 3.49838 0 11.1374 10.9761 0 0 0 0 0 0 0 A0A8I3P507 A0A8I3P507_CANLF X-ray repair cross complementing 4 XRCC4 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303] nucleus [GO:0005634] DNA binding [GO:0003677] APATLRGDDSIISS;TEPKMVSQVHQPQ 2 8.3 0.62281 0.34982 0 0 0 0 0 0 0 9.09808 11.5089 0 0 10.9999 0 0 0 A0A8I3P514 A0A8I3P514_CANLF STI1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983] AQREEEARRQSGAQY;DLALACKLDYD;EAAHDLALACK;GLNEILSDPEVPAAM;NEGVIEPDTDAPQE 5 16 0.99192 -0.29126 0 0 8.1635 0 0 0 10.2779 0 0 0 0 0 0 10.5179 0 A0A8I3P517 A0A8I3P517_CANLF Prolactin PRL Canis lupus familiaris (Dog) (Canis familiaris) female pregnancy [GO:0007565]; mammary gland development [GO:0030879]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of lactation [GO:1903489]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; response to nutrient levels [GO:0031667] extracellular space [GO:0005615] hormone activity [GO:0005179]; prolactin receptor binding [GO:0005148] QAQQIHVHPGIRENEVY;RAVILSHYIHNLSSEMFNEF 2 21.9 0.99315 -0.14389 0 0 0 0 0 6.5447 0 0 0 0 0 0 0 0 0 A0A8I3P518 A0A8I3P518_CANLF Family with sequence similarity 81 member A FAM81A Canis lupus familiaris (Dog) (Canis familiaris) CDASIARLSAEHKTTY;ESIGSLRQVLEAKMKLD;YESIGSLRQVLEAKMKLDKDQ 3 10.1 0.85248 0.14781 0 0 0 0 6.85786 8.22569 0 0 0 0 0 6.29583 0 0 9.20572 A0A8I3P521 A0A8I3P521_CANLF Snurportin-1 (RNA U transporter 1) SNUPN Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015] cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] nuclear import signal receptor activity [GO:0061608]; RNA binding [GO:0003723] FYWMHSKLPEEEGLEEKTKLNPF;ILDCIYSEVNQ;KHSSLEQSERRRR;SEWLIDVPSDLGQEWI 4 17.6 0.99217 -0.06554 0 0 11.8681 0 0 0 0 0 0 0 0 7.66092 0 0 0 A0A8I3P525 A0A8I3P525_CANLF T-box transcription factor 21 TBX21 Canis lupus familiaris (Dog) (Canis familiaris) cell fate specification [GO:0001708]; lymphocyte migration [GO:0072676]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]; T-helper 1 cell lineage commitment [GO:0002296] neuronal cell body [GO:0043025]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PMAPQYPPKMGPSGWFRTM;SQYPVPSRFYPD 2 5.8 0.93805 0.099951 0 0 0 0 0 0 0 0 0 0 0 0 0 8.48708 7.24251 A0A8I3P530 A0A8I3P530_CANLF Membrane spanning 4-domains A14 MS4A14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DISSQNIPYQSML;DKHQQDLKYTDTQKE;DKHQQDLKYTDTQKED;IGGYTFFKL;KWESQIQQTQDLLEKES;QDMQSEVKL;QTEDLQVQEEKSLKQP 7 9.2 0.98679 -0.39774 0 10.0848 10.8557 0 0 0 0 0 0 0 0 4.25391 10.4442 12.7503 11.598 A0A8I3P541 A0A8I3P541_CANLF Cyclic AMP-dependent transcription factor ATF-2 ATF2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "cAMP response element binding [GO:0035497]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" PVTMVPSVP 1 2.3 1.0035 -0.80421 0 0 0 0 0 0 7.75328 0 0 0 0 0 0 0 0 A0A8I3P550 A0A8I3P550_CANLF Ankyrin repeat domain 9 ANKRD9 Canis lupus familiaris (Dog) (Canis familiaris) intracellular copper ion homeostasis [GO:0006878]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] EPRQRRLLLLDLL 1 3 0.95091 0.059561 0 0 0 0 0 0 0 2.29366 0 0 0 0 0 0 0 A0A8I3P551 A0A8I3P551_CANLF mitogen-activated protein kinase (EC 2.7.11.24) MAPK4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EQGTLTEEHAK;SEVQRDPRAGSGSAA;STRGGPEPASPAPGSPER 3 7.5 0.99087 -0.51387 0 9.45485 0 3.95075 0 0 10.1762 0 0 3.95466 0 0 0 3.70764 0 A0A8I3P557 A0A8I3P557_CANLF Heat shock transcription factor 5 HSF5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837] DLHLLVDV;ENKKTEVNLE;GAGGGGGG;GGGGGGGG;ITSFVVGTEQAINCSLPQ;SPPGAGAG;TFPLKGLDRTPIPPRTW;VGQFHRSFRRDSLSP;VGTEQAINCSL 9 14.2 1.0019 -1.4734 0 0 11.6389 9.49817 7.13175 0 0 0 0 0 0 7.10622 10.0175 5.43263 0 A0A8I3P559 A0A8I3P559_CANLF POU-specific domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FAKPLKQKRITL 1 11.8 0.95174 0.05044 3.13683 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P563 A0A8I3P563_CANLF "Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase)" TMLHE Canis lupus familiaris (Dog) (Canis familiaris) carnitine biosynthetic process [GO:0045329] iron ion binding [GO:0005506]; trimethyllysine dioxygenase activity [GO:0050353] FELLTKVPLKHEYIENVGEYLS;FTWPDGHVTKYDLDW;LDRHTDTTYFQEP 3 12.3 0.99254 -0.042654 0 0 9.73622 0 8.65274 0 0 0 0 8.90295 0 8.52611 8.99432 8.93567 8.86712 A0A8I3P569 A0A8I3P569_CANLF small monomeric GTPase (EC 3.6.5.2) RERGL Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] HCKRAVES 1 3.6 0.99013 -0.2636 0 0 0 0 0 0 0 0 0 0 0 12.4166 11.99 0 0 A0A8I3P573 A0A8I3P573_CANLF "Polycystin 2 like 1, transient receptor potential cation channel" PKD2L1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to acidic pH [GO:0071468]; protein homotetramerization [GO:0051289]; response to water [GO:0009415]; smoothened signaling pathway [GO:0007224] actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; non-motile cilium [GO:0097730]; receptor complex [GO:0043235] calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; sodium channel activity [GO:0005272]; sour taste receptor activity [GO:0033040]; transmembrane transporter binding [GO:0044325] CLLTYGMTSS;LTAAFTRFDQDGNHI;LVDICLLTYG;SEFPGGREGEALE;SEVKEELAGQKDELQ;TISSAMPP 6 8.1 1.0023 -0.95923 0 0 0 0 0 0 9.92053 15.486 8.50096 0 0 0 9.21272 0 0 A0A8I3P575 A0A8I3P575_CANLF Spermatogenesis associated 4 SPATA4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LSRSVLRWLQ 1 3.3 0.99964 -0.61146 0 0 0 0 0 0 0 7.46663 0 0 0 0 0 0 0 A0A8I3P582 A0A8I3P582_CANLF TIA1 cytotoxic granule associated RNA binding protein like 1 TIAL1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; positive regulation of hippo signaling [GO:0035332]; positive regulation of miRNA-mediated gene silencing [GO:2000637] cytosol [GO:0005829]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; protein-RNA adaptor activity [GO:0140517] EQPDSRRVNSSVGFSVL;GYSFVRFST 2 6.6 1.0038 -1.0622 0 0 0 0 0 0 0 8.21461 0 0 0 0 0 0 0 A0A8I3P5A8 A0A8I3P5A8_CANLF Cyclin G2 CCNG2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] DESESEDSCEDMSCEES;SCEDMSCEESLSSSP;SEDSCEDM;SEDSCEDMS 4 6.4 1.0032 -2.136 7.46548 0 5.67711 0 0 0 0 0 0 0 0 0 5.01961 0 9.66571 A0A8I3P5B8 A0A8I3P5B8_CANLF Dystrophin related protein 2 DRP2 Canis lupus familiaris (Dog) (Canis familiaris) synaptic signaling [GO:0099536] plasma membrane [GO:0005886]; synapse [GO:0045202] zinc ion binding [GO:0008270] AAFGGSNVEPSVR;AGVSCLSP;AQDHRNEELLAEARILRQH;EIFNEHDLQ;ESQNCSFFNDSLSPDDSM;SVRSCFRFSTGKPVIEASQFLEWVN;TLTTALEIFNE 7 9.7 1.0025 -1.1631 0 4.27172 12.9944 11.1463 6.95954 0 0 0 11.3226 10.1319 0 0 0 0 9.8575 A0A8I3P5C3 A0A8I3P5C3_CANLF Ras responsive element binding protein 1 RREB1 Canis lupus familiaris (Dog) (Canis familiaris) AADGASPLLGVE;AAGGGGPG;DERGEEDSGSE;KEQGSQGDP;LPAEEVQPGD;LSKAPAAP;PLGPGGGP;QAAGDGQECEEQP;RHAKQHGKDSDKDERG;STALDSLGSTVP;TVCRLCGEDLKHYRAL;VPEHDIES 12 7.5 0.99691 -4.3976 9.60979 9.96527 9.71115 0 0 8.36142 0 0 9.89139 10.5311 10.3972 0 8.96976 0 0 A0A8I3P5C4 A0A8I3P5C4_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] PSLLLLPGT 1 2.2 1.0043 -0.80421 0 6.46159 0 0 0 0 5.99198 5.63395 0 0 0 0 0 0 0 A0A8I3P5C6 A0A8I3P5C6_CANLF Asialoglycoprotein receptor 2 ASGR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] VGGGEDCA;VLMRVCAHP 2 5.8 1.0027 -1.4033 0 0 0 0 0 7.87308 0 0 0 0 0 0 0 0 0 A0A8I3P5C7 A0A8I3P5C7_CANLF 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (EC 1.1.1.141) (EC 1.1.1.232) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (Prostaglandin dehydrogenase 1) HPGD Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin metabolic process [GO:0006693] EGGIIINMSSL 1 7.7 0.97844 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 7.03793 0 10.473 A0A8I3P5D0 A0A8I3P5D0_CANLF "Eva-1 homolog A, regulator of programmed cell death" EVA1A Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] EELERAQRLEERE;SSDSSDSEDGSSDTASDISV 2 23.7 0.97348 0.048206 0 6.66888 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5D3 A0A8I3P5D3_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) DUSP15 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] protein tyrosine phosphatase activity [GO:0004725] PGLYLGNFIDAKDPD 1 6.5 0.94803 0.05525 6.33771 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5E2 A0A8I3P5E2_CANLF Kelch like family member 26 KLHL26 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGFWFFWFYFGSVLLFFK;FVYVAGGQHLQYRS;GFWFFWFYFGSVLL;HIIDFAYSAEVTLDLD;LMRSSDLVDSVQTLDIM;WCVLFLSRALWHLWPH 6 11.9 1.0022 -0.66751 0 0 0 7.67751 10.7469 8.91874 0 0 10.177 0 0 0 0 0 0 A0A8I3P5E5 A0A8I3P5E5_CANLF Iodotyrosine deiodinase 1 (EC 1.21.1.1) (Iodotyrosine dehalogenase 1) IYD Canis lupus familiaris (Dog) (Canis familiaris) tyrosine metabolic process [GO:0006570] cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] FMN binding [GO:0010181]; iodotyrosine deiodinase activity [GO:0140616] ALQNAGLVT;HTRYPEKEMIKRSQEFYE;VLILIFKQV 3 12.4 1.0032 -0.86847 8.5678 0 0 0 0 0 4.98167 0 0 0 0 0 0 7.36982 0 A0A8I3P5J3 A0A8I3P5J3_CANLF Transcription factor CP2 TFCP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DRRLQYTEHQQLEGWRWNR;LKLPLADEVIESGLVQDFD;VFIQPKGAD 3 10.4 0.98579 -0.43274 9.27382 0 8.52521 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5K2 A0A8I3P5K2_CANLF Glutathione S-transferase LANCL1 (EC 2.5.1.18) (LanC-like protein 1) LANCL1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; cellular detoxification [GO:1990748]; peptide modification [GO:0031179] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; low-density lipoprotein particle receptor binding [GO:0050750]; SH3 domain binding [GO:0017124]; zinc ion binding [GO:0008270] AESYFDCAGRLTPEFS;HNLVKPSV;PCVDDNRD 3 8 1.0036 -1.6354 10.3311 0 10.0351 0 0 0 0 0 0 0 10.921 0 10.8767 0 8.82493 A0A8I3P5K6 A0A8I3P5K6_CANLF Complexin 3 CPLX3 Canis lupus familiaris (Dog) (Canis familiaris) insulin secretion [GO:0030073]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079] cytosol [GO:0005829]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone membrane [GO:0048787]; synaptic vesicle membrane [GO:0030672] neurotransmitter transmembrane transporter activity [GO:0005326]; syntaxin binding [GO:0019905] GGGEDKGDGDKSAAEAQ;KAERATLRSHFRDKYRL 2 21.5 0.98491 0.046227 0 0 0 0 0 0 0 0 9.70945 0 0 0 0 0 0 A0A8I3P5L1 A0A8I3P5L1_CANLF Uncharacterized protein SPRY3 Canis lupus familiaris (Dog) (Canis familiaris) animal organ development [GO:0048513]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580] cytosol [GO:0005829]; membrane [GO:0016020] DDEDNCADE;FYHCSTDDEDNCADEPCSCGP;GEAEQSAVHPSEH;LATMPTALPRSLS;LFYHCSTDDEDNCADE;PSCWLCNQRC;STDDEDNCADEPCSCG;YHCSTDDEDNCADEPCS;YHCSTDDEDNCADEPCSCG 9 20.1 1.0032 -1.704 8.35138 0 11.5109 0 0 0 7.76699 7.87363 8.42068 0 6.52907 11.1174 0 0 0 A0A8I3P5L7 A0A8I3P5L7_CANLF Protein smoothened SMO Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; commissural neuron axon guidance [GO:0071679]; contact inhibition [GO:0060242]; dentate gyrus development [GO:0021542]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial cell proliferation [GO:0050673]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; gene expression [GO:0010467]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell migration [GO:0001755]; neuroblast proliferation [GO:0007405]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of somatic stem cell population maintenance [GO:1904672]; skeletal muscle fiber development [GO:0048741]; smooth muscle tissue development [GO:0048745]; smoothened signaling pathway [GO:0007224]; somite development [GO:0061053]; spinal cord dorsal/ventral patterning [GO:0021513]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371] 9+0 non-motile cilium [GO:0097731]; caveola [GO:0005901]; centriole [GO:0005814]; ciliary membrane [GO:0060170]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770] cAMP-dependent protein kinase inhibitor activity [GO:0004862]; G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142]; patched binding [GO:0005113]; protein kinase A catalytic subunit binding [GO:0034236]; protein sequestering activity [GO:0140311] ISPELEKRLGRKKKRRKRK;LVEAEISPELEKRLGRKKKRR;TVAILAVAQVDGDSVS;TWVWTKATLLIWRRTWC;TYQPLSGKTSYFHLLTWSLP 5 9.8 0.99428 -0.024654 7.8622 0 8.65735 0 0 0 0 0 0 0 7.91654 0 0 0 8.14052 A0A8I3P5L9 A0A8I3P5L9_CANLF Neuronal guanine nucleotide exchange factor NGEF Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] NILEKTEDGEAGGWAYPHSCHPLP;QEIETRRQQDAEI;RITRLKLLIQNILKRVEERS;TPEEEEDEEEEEDEPAS 4 10.1 0.83731 0.19558 10.3942 0 0 0 0 0 0 0 0 5.37267 7.96521 0 0 7.77208 0 A0A8I3P5M0 A0A8I3P5M0_CANLF Calpain-3 (EC 3.4.22.54) CAPN3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737]; nucleolus [GO:0005730] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] DQESEEQLQFRNIFRQ;ETSLFYSQKFP;VIVPSTYEPHQ 3 5.2 0.9852 -0.44043 0 0 5.60048 0 0 0 10.0634 0 0 0 0 0 9.40973 0 0 A0A8I3P5M1 A0A8I3P5M1_CANLF GTP binding protein 6 (putative) GTPBP6 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; metal ion binding [GO:0046872] AGEQEEEEEDPGDAEQEEE;GVADVTVVISSSAY 2 5.2 0.93288 0.060848 0 0 0 0 0 0 0 0 9.34917 0 0 0 0 0 0 A0A8I3P5M7 A0A8I3P5M7_CANLF Myoneurin MYNN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ISSGELNKHFRSHTGAD;LDVKPSDMTLP;YVCDTCGKAFAVSSSLIT 3 7.9 0.98733 -0.32647 0 0 0 0 0 8.57698 0 0 0 12.7901 0 0 0 0 0 A0A8I3P5N0 A0A8I3P5N0_CANLF Twinkle mtDNA helicase TWNK Canis lupus familiaris (Dog) (Canis familiaris) DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; protein hexamerization [GO:0034214] mitochondrial nucleoid [GO:0042645] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protease binding [GO:0002020]; single-stranded DNA binding [GO:0003697] AAKLFARKLNPKRCSLVRPG;CLPPALLPYL;IVSFRQLREEVLGELSN;LVFPWLSP;SRELDSLALNQATGLP;WSARSLVFPWLSPG 6 11.3 1.0013 -0.93774 0 0 9.84855 0 10.707 0 8.41075 0 0 0 11.1148 0 0 10.5337 0 A0A8I3P5N8 A0A8I3P5N8_CANLF Centromere protein N CENPN Canis lupus familiaris (Dog) (Canis familiaris) CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" DIHMDSRIIHENRIEKER;VWDVFQMSKGPGE 2 10.2 0.99055 -0.26845 0 0 0 0 6.70099 0 0 0 0 0 0 0 0 0 0 A0A8I3P5Q0 A0A8I3P5Q0_CANLF Uncharacterized protein LOC609557 Canis lupus familiaris (Dog) (Canis familiaris) RLCRCVFAALHCLPRQTPG;TRPYFHAFQDLGASSPP 2 18.5 0.98907 -0.22379 0 0 0 0 0 0 0 0 0 7.80465 0 0 0 0 0 A0A8I3P5Q1 A0A8I3P5Q1_CANLF APC membrane recruitment protein 3 AMER3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTGTPKSEQPESV;ECLLKLCDTE 2 2.9 0.98678 -0.33618 0 0 10.791 0 0 0 0 0 0 0 11.4969 0 0 0 0 A0A8I3P5Q3 A0A8I3P5Q3_CANLF Phospholipid transfer protein PLTP Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] EFLSTFIT;LVPSDQPEVQ;TQLDLRRFRIYS 3 7.5 1.0044 -0.81985 0 0 0 0 0 0 0 0 0 9.63791 9.14461 0 0 0 0 A0A8I3P5R2 A0A8I3P5R2_CANLF Cyclin-dependent kinase 2-associated protein CDK2AP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; NuRD complex [GO:0016581]; perinuclear region of cytoplasm [GO:0048471] DNA polymerase binding [GO:0070182] AAHMPAASLSAAGSVHPPSTS 1 18.3 0.94865 0.050031 0 0 0 0 0 0 0 0 0 0 4.7126 0 0 0 0 A0A8I3P5R8 A0A8I3P5R8_CANLF Olfactory receptor OR4N5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ASYSFIVAPRMLVD;SLFHTVIFPLMN 2 8.4 0.91402 0.1115 0 0 0 0 0 7.73633 0 5.08967 6.83845 0 0 5.55845 0 0 0 A0A8I3P5T4 A0A8I3P5T4_CANLF N-terminal amino-acid N(alpha)-acetyltransferase NatA (EC 2.3.1.255) NAA11 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatA complex [GO:0031415]; nucleoplasm [GO:0005654] peptide alpha-N-acetyltransferase activity [GO:0004596] KRDLSQMADELRRQ 1 6.1 0.93734 0.060951 0 0 0 0 0 0 0 4.2902 0 0 0 0 0 0 0 A0A8I3P5T6 A0A8I3P5T6_CANLF Solute carrier family 39 member 10 SLC39A10 Canis lupus familiaris (Dog) (Canis familiaris) epithelial to mesenchymal transition [GO:0001837]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; zinc ion import across plasma membrane [GO:0071578] apical plasma membrane [GO:0016324] monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385] AENEKKYYI;ESKLPKGKRKRKGKKS;GGISTSIAVFCHELPHELGDFAV;GSGRRRWRFRSGGKIEMKVHMHT;MHDHSHRLCHHHCLHHH;VLDAENEKKYYIEKLFD 6 11.3 0.9881 -0.37654 0 0 0 0 0 8.60121 0 10.6004 0 0 0 0 0 0 4.62065 A0A8I3P5T7 A0A8I3P5T7_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) VCPIP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567] cysteine-type deubiquitinase activity [GO:0004843] LLRDMNQGELFD;NVLHRPIILLDS;SELHVPPEWLAPG 3 3.1 0.99068 -0.53815 9.94147 0 10.4277 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5T9 A0A8I3P5T9_CANLF Cell division control protein 42 homolog (EC 3.6.5.2) Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cellular component organization [GO:0051130]; small GTPase-mediated signal transduction [GO:0007264] membrane-bounded organelle [GO:0043227]; midbody [GO:0030496]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DLKAVKYVKCSALTQKG 1 8.8 0.98963 -0.26616 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7154 0 A0A8I3P5U1 A0A8I3P5U1_CANLF "Propionyl-CoA carboxylase beta chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)" PCCB Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] ligase activity [GO:0016874] AVMGAKGA;IAVMGAKGAVEI;LVYVFSQIMDQAMTV 3 5.2 1.0023 -0.97016 0 0 0 0 0 0 0 0 15.6431 0 0 15.3816 16.4503 16.573 0 A0A8I3P5U3 A0A8I3P5U3_CANLF Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (Lysosomal DNase II) DNASE2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic DNA fragmentation [GO:0006309]; enucleate erythrocyte differentiation [GO:0043353]; regulation of immune response [GO:0050776] lysosome [GO:0005764] deoxyribonuclease II activity [GO:0004531] PWNSSVTLTSKAGD 1 3.8 0.9847 -0.25754 0 0 0 0 0 0 0 0 0 0 10.8597 0 0 0 0 A0A8I3P5U5 A0A8I3P5U5_CANLF Leucine-rich repeat-containing protein 37 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) STTLHQTTAPPKD;VTVHPVDMGLTIT 2 3.9 0.93959 0.059722 0 0 0 0 0 0 6.02481 0 0 0 0 0 0 0 0 A0A8I3P5U6 A0A8I3P5U6_CANLF Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; fibroblast activation [GO:0072537]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of autophagy [GO:0010506]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AQDLLRDGPG;DLEHMPSG;PGSGFGCH;YEALFGQPPFASRSFTELEEKI 4 10.1 0.989 -0.51883 0 6.07118 0 8.20129 7.14292 7.83908 0 0 0 8.88066 0 8.74839 7.94462 0 10.3211 A0A8I3P5W0 A0A8I3P5W0_CANLF FERM domain containing 4A FRMD4A Canis lupus familiaris (Dog) (Canis familiaris) establishment of epithelial cell polarity [GO:0090162] cytoskeleton [GO:0005856] EGGATPVV;IRSLPHWNSQSSMPST;KPKMWSESSLDEPYEKVKK;LDPGEEPPIV;PDSALSLL;QLENLYFREKKF;RKLELLVQPKLLAKEL;SGPVVLYF;SNGSDPMDDCSSCT;TSAALPQSQRSSTPSSEI 10 12.5 0.99714 -4.0297 12.4881 0 10.509 10.1403 10.1316 0 7.53784 0 6.17479 12.1148 0 0 0 8.37721 0 A0A8I3P5W5 A0A8I3P5W5_CANLF Nuclear RNA export factor 2-like LOC492024 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] EQLKVMQTQGPLCL;KTQHDLSSLVVDMWFQTEKM;QPTYISAIRDC 3 8.2 0.94081 0.061072 0 0 0 0 0 0 0 0 0 8.9472 0 0 0 0 0 A0A8I3P5W8 A0A8I3P5W8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) NMELRWFHSRFSEVVFIYQN;WFHSRFSEVVFIYQN 2 13.4 0.93973 0.1025 0 8.35839 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5X5 A0A8I3P5X5_CANLF "Polyunsaturated fatty acid lipoxygenase ALOX15 (EC 1.13.11.12) (EC 1.13.11.31) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (Arachidonate 15-lipoxygenase) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (Linoleate 13S-lipoxygenase)" ALOX15 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic cell clearance [GO:0043277]; arachidonic acid metabolic process [GO:0019369]; bone mineralization [GO:0030282]; lipid oxidation [GO:0034440]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxygenase pathway [GO:0019372]; negative regulation of adaptive immune response [GO:0002820]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of actin filament polymerization [GO:0030838]; regulation of engulfment of apoptotic cell [GO:1901074]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; response to endoplasmic reticulum stress [GO:0034976]; wound healing [GO:0042060] cytosol [GO:0005829]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; lipid binding [GO:0008289] DQSKLAKKVRDSWKEDALFG;LAKKVRDSWKED;PPGMEELQI;TDPPMVWLLAKCWVRSS 4 6.9 0.98543 -0.43924 0 0 0 0 0 0 8.60707 7.01625 0 0 8.24608 0 0 0 0 A0A8I3P5X8 A0A8I3P5X8_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] HLFFVMFVWSY;SACDMVNNCVGFSN 2 5.9 0.98922 -0.51834 0 0 0 0 0 0 0 0 0 0 0 0 0 9.88531 0 A0A8I3P5Y0 A0A8I3P5Y0_CANLF Tetratricopeptide repeat domain 17 TTC17 Canis lupus familiaris (Dog) (Canis familiaris) AINSSEPLT;QGKKRDYQSLGWP;TDCAESYPRVPIGGELPTYF;TWLAVSSKNIDITEH 4 5.3 0.99293 -0.15051 0 0 10.3566 0 0 0 0 0 0 0 0 0 0 9.99025 0 A0A8I3P5Y2 A0A8I3P5Y2_CANLF Family with sequence similarity 186 member B FAM186B Canis lupus familiaris (Dog) (Canis familiaris) ESKVERREEELSWERQR;IDSLQNFWLQ;LYFQNSLQVLQT 3 4.5 1.0022 -0.68723 0 10.5546 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P5Y6 A0A8I3P5Y6_CANLF Serum amyloid A protein SAA1 Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953] high-density lipoprotein particle [GO:0034364] DAARRGPGGAW;DMREANYKNSDKYFHA;DPNHFRPAG;FGDSGHGAEDSKADQAANE;PNHFRPAGL;SDMREANYKNSDKYFHA;VISDAREN 7 50 0.98119 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 11.358 0 0 A0A8I3P5Z2 A0A8I3P5Z2_CANLF T cell receptor beta variable 18 TRBV18 Canis lupus familiaris (Dog) (Canis familiaris) LGEGLKFMIYLQ 1 8 0.9446 0.05044 0 0 0 0 0 10.3625 0 0 0 0 0 0 0 0 0 A0A8I3P5Z6 A0A8I3P5Z6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPYCCS;PICCEASPCSASPCCQQSSCQ;VCCKPDSCPGSCQPSCGSCS 3 13.2 0.97272 0.048206 0 0 0 0 5.71227 0 0 0 0 0 0 0 0 0 0 A0A8I3P602 A0A8I3P602_CANLF CREB regulated transcription coactivator 2 CRTC2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; nucleus [GO:0005634] cAMP response element binding protein binding [GO:0008140] GVPLDTSKLSTDQR;LSSQACSMQPSG;SPLSLPAG;VLPSQAPT 4 11.3 1.0019 -0.6752 0 0 0 7.64767 6.61126 0 0 0 0 10.7802 0 5.15717 8.06264 0 7.46948 A0A8I3P603 A0A8I3P603_CANLF Stress-activated protein kinase JNK (EC 2.7.11.24) MAPK8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065]; response to mechanical stimulus [GO:0009612]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein serine kinase activity [GO:0106310] EVILGMGYKENADSE;GIVCAAYDAI;NFYSVEIGDSTFT 3 12.3 0.99218 -0.18451 0 0 0 0 0 0 0 0 9.82733 0 0 0 9.14328 0 0 A0A8I3P609 A0A8I3P609_CANLF Olfactory receptor OR51M1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIFRGPVALVPLVVLLKTFP 1 6.1 0.97314 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 6.21265 0 A0A8I3P611 A0A8I3P611_CANLF Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) PIN4 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] TDPPIRTEFGYHIIMVEGRK 1 15.3 0.9664 0.048572 0 0 0 0 0 0 7.20584 0 0 0 0 0 0 0 0 A0A8I3P615 A0A8I3P615_CANLF Cytochrome P450 26B1 CYP26B1 Canis lupus familiaris (Dog) (Canis familiaris) bone morphogenesis [GO:0060349]; cell fate determination [GO:0001709]; cellular response to retinoic acid [GO:0071300]; cornification [GO:0070268]; embryonic limb morphogenesis [GO:0030326]; establishment of skin barrier [GO:0061436]; establishment of T cell polarity [GO:0001768]; inflammatory response [GO:0006954]; male meiotic nuclear division [GO:0007140]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; positive regulation of gene expression [GO:0010628]; positive regulation of tongue muscle cell differentiation [GO:2001037]; proximal/distal pattern formation [GO:0009954]; regulation of T cell differentiation [GO:0045580]; retinoic acid catabolic process [GO:0034653]; retinoic acid receptor signaling pathway [GO:0048384]; spermatogenesis [GO:0007283]; tongue morphogenesis [GO:0043587]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972]" HLVSTEWPR;IPKGWSVMYSIRD;LVSTEWPRSTRML;TQGKDYSDALDILIESSKEH 4 9.2 1.0038 -0.83134 0 8.75962 0 8.93384 0 8.23223 0 0 7.14292 0 0 0 0 0 0 A0A8I3P617 A0A8I3P617_CANLF Homeobox C12 HOXC12 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" RRMKKKRLLLRE;VGPGAALLPL 2 7.9 0.99462 -0.56102 0 0 0 0 0 0 0 0 0 0 0 0 7.20163 0 3.62152 A0A8I3P619 A0A8I3P619_CANLF cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) CARS2 Canis lupus familiaris (Dog) (Canis familiaris) cysteinyl-tRNA aminoacylation [GO:0006423] mitochondrion [GO:0005739] ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872] AYSTAQVD;GGRSSSAVGGRGRVPSGVG;RRCACCVG 3 4.4 1.0024 -0.72656 7.80793 0 0 0 0 0 0 0 0 0 0 9.45744 0 0 0 A0A8I3P630 A0A8I3P630_CANLF Centrosomal protein 57 CEP57 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874] gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017] EAKLREEQQER;TVELKDNLECELEAL 2 5.5 0.98473 -0.24659 0 0 0 0 0 0 0 0 0 0 0 5.51819 0 0 0 A0A8I3P634 A0A8I3P634_CANLF Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1) CMKLR2 Canis lupus familiaris (Dog) (Canis familiaris) glucose homeostasis [GO:0042593]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] adipokinetic hormone binding [GO:0097004]; adipokinetic hormone receptor activity [GO:0097003]; complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930] ETKNLCLLETAQ;FNIWELTIHHNSHFHQVL;ILYVLISK;PLYISYVAMNFHW;TVTTLWFLNL 5 17.2 1.0033 -1.5678 0 0 0 8.24722 0 0 9.96665 0 7.94638 0 0 0 0 0 4.44712 A0A8I3P636 A0A8I3P636_CANLF WD repeat domain 54 WDR54 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408] intracellular membrane-bounded organelle [GO:0043231]; vesicle [GO:0031982] protein homodimerization activity [GO:0042803] EGAGVSPP;EVEHCHGE;GVPCPSVQLWHG;VLLVLTSHRGI 4 11.7 1.0009 -2.7366 0 0 0 0 0 9.05156 0 10.1226 0 10.813 0 0 0 9.77517 0 A0A8I3P637 A0A8I3P637_CANLF Tribbles pseudokinase 3 TRIB3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of glucose transmembrane transport [GO:0010827] nucleoplasm [GO:0005654] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106] EALAVLEPYSRLPP;PPAPARAL;VAGPRHLYTFFPR 3 9.8 0.98687 -0.39731 0 0 0 0 0 10.7234 0 0 0 0 0 11.1523 0 0 0 A0A8I3P647 A0A8I3P647_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTPase regulator activity [GO:0030695] NNRMDDQRCCLQE 1 5.8 0.93962 0.059848 0 0 0 0 0 7.40071 0 0 0 0 0 0 0 0 0 A0A8I3P650 A0A8I3P650_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK39 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ASGCDGSE;GAGGGGGG;GAKGMLAG;GGGGGGGG;GSAGVARARPGDPGA;LEKCQTSMDELLKEIQ;PGSSGHLHKTEDGDWEWSDDEM;RPPCSLPSGLRRRRRRGGEGV 8 13.8 1.0002 -2.8184 11.1137 6.12908 0 9.8489 9.5306 0 0 0 5.41576 0 0 0 13.1525 0 0 A0A8I3P651 A0A8I3P651_CANLF Sterol regulatory element-binding protein 2 (Sterol regulatory element-binding transcription factor 2) SREBF2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; SREBP signaling pathway [GO:0032933] ER to Golgi transport vesicle membrane [GO:0012507]; nucleoplasm [GO:0005654]; SREBP-SCAP-Insig complex [GO:0032937] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" APPQDQPPPPHHDLSPRQT;FQHRRAAPATT;LDLARGDFAAAAANLQTCL;PAGSACSD;PGSPLLDDAKVKD;RYSLQKLRLV;SHPGAPMP;TVMITPTFSTAP;VGSNGTILTTMP;VIRYSLQKLRLVRWLLK 10 9.9 0.99903 -2.944 4.53903 0 0 0 0 9.83115 0 10.0825 11.3561 0 0 7.39515 0 9.07329 9.76676 A0A8I3P659 A0A8I3P659_CANLF Calcium-activated chloride channel regulator 1 CLCA1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020]; microvillus [GO:0005902]; secretory granule [GO:0030141] intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GVTLQNNQW;ILIPEKWK;VYDEYNNDQKFYL 3 3.3 1.0032 -1.5926 0 5.32693 0 0 0 9.7904 0 0 0 0 0 0 0 0 0 A0A8I3P662 A0A8I3P662_CANLF Retinol dehydrogenase (EC 1.1.1.300) RDH8 Canis lupus familiaris (Dog) (Canis familiaris) estrogen biosynthetic process [GO:0006703]; visual perception [GO:0007601] cytoplasm [GO:0005737]; membrane [GO:0016020] all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] AVDPSGSLYVRTTHCLLF;IQGGEVDVLVNNAGV;TTEFPDTDPDTLHYFRDI 3 15.4 0.99251 -0.1328 0 0 6.43409 0 0 0 0 0 0 5.11316 0 9.74831 0 0 0 A0A8I3P684 A0A8I3P684_CANLF Lumican LUM Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914] extracellular region [GO:0005576]; fibrillar collagen trimer [GO:0005583] collagen binding [GO:0005518] PSAMYCDE;YLEVNELEKFEVKSFC 2 7.1 1.0038 -1.0552 0 0 7.64904 0 3.82038 0 0 0 0 0 0 0 0 0 0 A0A8I3P6A6 A0A8I3P6A6_CANLF Aquaporin-2 (ADH water channel) (Aquaporin-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct) AQP2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; cellular response to copper ion [GO:0071280]; cellular response to mercury ion [GO:0071288]; cellular response to water deprivation [GO:0042631]; metanephric collecting duct development [GO:0072205]; protein homotetramerization [GO:0051289]; renal water transport [GO:0003097] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; lumenal side of membrane [GO:0098576]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037] glycerol transmembrane transporter activity [GO:0015168]; water channel activity [GO:0015250] RQSVELHSPQSLPRGS 1 5.9 0.98178 -0.24965 0 0 0 0 0 0 0 10.2444 0 0 0 0 0 0 0 A0A8I3P6A9 A0A8I3P6A9_CANLF ER membrane protein complex subunit 4 EMC4 Canis lupus familiaris (Dog) (Canis familiaris) VGYLDKQVPDTSVQ 1 17.9 0.98247 -0.24848 0 0 0 0 9.22827 0 0 0 0 0 0 0 0 0 0 A0A8I3P6B4 A0A8I3P6B4_CANLF Syntaxin binding protein 5 STXBP5 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] CFTNNGQAL;LRGDIVALSNS;VASDIDIKDNSFS 3 3.1 0.98964 -0.52935 0 11.6024 0 0 0 0 0 9.80161 0 0 0 0 0 0 0 A0A8I3P6B9 A0A8I3P6B9_CANLF Lethal(3)malignant brain tumor-like protein 2 L3MBTL2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270] CSRSYSSN;EDGDSDDDFWCHMWSP;ELTGYQLQ;FDGWDSEYDQWVDCESPD;GFENDASHDFWC;KAKEATKKKK;KKKKQFGKKRVRIPRKKARNSIC;PTKKAKVLH;SDDDFWCHMWSPL;TDWKGYLMKRLVG 10 17.1 0.97958 0.046253 0 0 0 0 0 0 0 0 7.16601 0 0 0 0 0 0 A0A8I3P6C2 A0A8I3P6C2_CANLF Zinc finger protein 653 ZNF653 Canis lupus familiaris (Dog) (Canis familiaris) extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of transcription by RNA polymerase II [GO:0000122] extracellular region [GO:0005576] "AF-2 domain binding [GO:0050682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]" CGKRFEKLDS;DEVPCAMME;EIPKEPEKRRRSK;GKPWEQVPKKP;KPKRKKRRRRNVNCL;VPESAEPEAEVDG;WEQVPKKPKRKKRRRR 7 11.1 1.0025 -1.7583 9.53286 0 4.92974 0 0 4.66357 10.7186 0 9.2876 6.6081 0 0 9.74369 0 0 A0A8I3P6C6 A0A8I3P6C6_CANLF Chromosome 17 C2orf81 homolog C17H2orf81 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] DPMWCEDEE;EDPMWCEDEEPLACTT;KPLNLIQSYD;LVWSPGSVLLILVLLR;SPGSVLLILVLLR;VGPFLLTNLLQGAL 6 11 1.0033 -1.5718 0 9.09482 0 9.43066 0 0 0 6.97865 0 9.60624 0 0 0 7.68124 0 A0A8I3P6E1 A0A8I3P6E1_CANLF Uncharacterized protein RWDD2B Canis lupus familiaris (Dog) (Canis familiaris) HIYNKCKRK;VRSVSLSRSQQTQLNTDL 2 9.3 0.99637 -0.57155 0 0 0 0 0 0 0 9.87438 0 0 0 0 0 0 0 A0A8I3P6E3 A0A8I3P6E3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SFQINSHYWCNDD 1 9 0.94061 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 5.4782 0 0 A0A8I3P6E7 A0A8I3P6E7_CANLF Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) GNB1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834] signaling receptor complex adaptor activity [GO:0030159] AGVLAGHDNRV;PQITNNIDPVGRI 2 7.4 0.93707 0.059846 0 0 0 0 0 0 0 0 0 0 0 0 0 7.61949 0 A0A8I3P6F1 A0A8I3P6F1_CANLF Kinesin-like protein KIF3B Canis lupus familiaris (Dog) (Canis familiaris) anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; cilium assembly [GO:0060271]; intraciliary transport [GO:0042073]; mitotic spindle assembly [GO:0090307]; opsin transport [GO:0036372]; spindle elongation [GO:0051231]; vesicle-mediated transport [GO:0016192] centrosome [GO:0005813]; cilium [GO:0005929]; dendrite cytoplasm [GO:0032839]; kinesin II complex [GO:0016939]; microtubule [GO:0005874] ATP binding [GO:0005524]; intraciliary transport particle B binding [GO:0120170]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; small GTPase binding [GO:0031267] EEEEEGEEGEEEGDD;EGEEGEEEGDDKDDYWREQQEKLEI;EKRSIGRR;GGGSGGGGE;PKGVAHEMP;YQEEIRDLLSKDQTKR;YSSLQQEVDIKT 7 11.1 1.0037 -1.9688 0 10.2774 0 0 7.47897 0 0 10.3778 9.83755 8.13556 0 0 0 0 9.2494 A0A8I3P6F4 A0A8I3P6F4_CANLF Exocyst complex component EXOC6 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145]; membrane [GO:0016020] ADYDWTMSEPD;DEFVQLADYDW;DSELKQISMGAVQ;EEEDENEEEGDEET;EEEYKAVISKFPFQDP;EKLDACIRNH;ESIRKHSDKIGETAMKQAQ;NEEEGDEETFENYYRK;STDTACVGPTLRSVYDDQP;VISKFPFQDPDFEKQ 10 17.1 1.0029 -1.6309 8.97611 10.3811 8.33208 0 8.70408 7.7666 10.554 0 7.58075 6.71397 0 0 0 11.5332 0 A0A8I3P6K0 A0A8I3P6K0_CANLF "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3)" ST6GALNAC2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] VGPCAPGP 1 1.5 0.98919 -0.26592 0 0 0 0 0 0 9.80256 0 0 0 0 0 10.3723 0 0 A0A8I3P6K2 A0A8I3P6K2_CANLF Olfactory receptor LOC119864888 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVARLACA;ISSRSFCIILPVIFLLTRLPF 2 9.1 0.978 0.047674 0 0 0 0 0 0 0 0 0 0 5.4971 0 0 0 0 A0A8I3P6L0 A0A8I3P6L0_CANLF Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; transferase activity [GO:0016740] DTHSSTFNAGAG;FGIVEGLMTTAHAITATQ 2 8.9 0.94237 0.05044 0 0 0 0 0 0 0 0 0 0 8.14451 0 0 0 0 A0A8I3P6L4 A0A8I3P6L4_CANLF Uncharacterized protein H1-5 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527] AGAKKAVKKTPKKAK;ETAPAETAVP;GVKKVAKSPKKVKTSAK;KAVKKTPKKAKKPA 4 19.9 1.0025 -1.1492 0 0 0 0 2.69884 0 0 7.09106 0 5.32937 0 2.35899 0 0 0 A0A8I3P6L8 A0A8I3P6L8_CANLF Protein SPT2 homolog SPTY2D1 Canis lupus familiaris (Dog) (Canis familiaris) heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713] DEEDEDEYDS;DEEDEDEYDSEMEDF;EYEDEEDEDEYD;FPSSYKRQREYEDEEDEDEYDSEM;KRRKAKKLKKR;QAVESHTSQGT;QEYEMEEE;RQREYEDEEDEDEYDSEMEDFIED;VGSSSGPG;VKKRIELKHDK 10 11.4 1.0027 -2.5268 3.73129 0 0 6.71218 0 9.77523 3.20356 8.87461 6.96012 2.60091 9.08204 0 0 7.92202 6.55007 A0A8I3P6L9 A0A8I3P6L9_CANLF PAK1 interacting protein 1 PAK1IP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] DKKVPPSLLC;LEKKKRKKKK;TDKTLRTWNLVE 3 8.2 1.0024 -1.1725 0 8.77288 0 0 0 0 0 10.0831 8.30159 0 0 0 0 4.11695 3.09395 A0A8I3P6M5 A0A8I3P6M5_CANLF Cyclic nucleotide gated channel subunit alpha 3 CNGA3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] AWATRHLNREAQRPDSFLE;GYSDLFCL 2 4 0.95072 0.057548 0 10.1839 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6M6 A0A8I3P6M6_CANLF Novel acetylcholine receptor chaperone TMEM35A Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of protein localization to cell surface [GO:2000010] endoplasmic reticulum membrane [GO:0005789] acetylcholine receptor regulator activity [GO:0030548] FMGTIKLT 1 4.7 1.0044 -1.1044 0 0 0 8.81083 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6M7 A0A8I3P6M7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; proteasome complex [GO:0000502] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DFKKSKENVLYR;EKTPQETYADIRALD;GHGPGGGK;HGPGGGKK;VGKKKKKTK 5 10.2 1.0014 -2.6635 0 11.2944 11.2674 9.2688 0 0 9.68363 7.95994 10.0462 0 10.4521 0 10.2734 0 0 A0A8I3P6N2 A0A8I3P6N2_CANLF IZUMO family member 2 IZUMO2 Canis lupus familiaris (Dog) (Canis familiaris) GVIVSSAIMYRQNRK 1 6.8 0.95187 0.053888 0 0 0 0 7.15066 0 0 0 0 0 0 0 0 0 0 A0A8I3P6N7 A0A8I3P6N7_CANLF AAA+ ATPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytosolic proteasome complex [GO:0031597]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] HIDLPNEQARLDILKIHAGPI 1 9.1 0.97785 0.047802 0 0 0 0 0 6.82947 0 0 0 0 0 0 0 0 0 A0A8I3P6N8 A0A8I3P6N8_CANLF Antagonist of mitotic exit network 1 homolog AMN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microvillus membrane [GO:0031528] EAVLTCCPQIRIL 1 5 0.9911 -0.27309 0 0 0 0 0 0 0 0 0 0 8.78218 0 0 0 0 A0A8I3P6P2 A0A8I3P6P2_CANLF Uncharacterized protein C35H6orf52 Canis lupus familiaris (Dog) (Canis familiaris) QDEDPLEDP 1 14.3 1.0046 -0.80421 0 0 0 0 0 8.36124 0 0 0 0 0 0 0 0 0 A0A8I3P6P5 A0A8I3P6P5_CANLF NDUFA4 mitochondrial complex associated Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EPWNKLGP;RLSLSPLFIFI;SLSPLFIFIGA 3 17.4 1.0032 -1.3347 0 0 0 0 0 0 10.793 0 0 7.12153 7.28059 0 0 0 0 A0A8I3P6Q3 A0A8I3P6Q3_CANLF Amino acid transporter SLC1A6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] glutamate:sodium symporter activity [GO:0015501]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175] AESAAHAPAPADHD;DRQCCGHWGQSGLCPATVPAYLPPD;EGLGVDRRITRF;NMFPPNLVEACFKQ;PGGLAAAA 5 14.7 1.0017 -1.2731 0 7.44253 0 0 9.12923 0 0 0 0 0 9.30163 0 5.34706 0 0 A0A8I3P6Q6 A0A8I3P6Q6_CANLF Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) MTFP1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266] mitochondrion [GO:0005739] DTWVRYLGY;TWVRYLGY;YGVSSSYVLADAID 3 31.1 1.0018 -1.2539 0 0 6.76487 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6R0 A0A8I3P6R0_CANLF Homeobox domain-containing protein ESX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" HRTQYPDVFAREEIAG 1 6.1 0.99009 -0.21981 0 0 0 0 0 0 10.0958 0 0 0 0 0 0 0 0 A0A8I3P6R4 A0A8I3P6R4_CANLF Uncharacterized protein LOC475367 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] SRLLQDAGHQVI 1 2 0.9872 -0.23024 0 9.04702 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6T0 A0A8I3P6T0_CANLF Ras-related protein Rab-3 RAB3D Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904] endosome [GO:0005768]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] EDGRRLADDLGFEFF 1 6.8 0.99038 -0.20162 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8678 0 A0A8I3P6U1 A0A8I3P6U1_CANLF Transmembrane protein 87A TMEM87A Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to mechanical stimulus [GO:0071260]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580] CYNEIYNFKGEEVETYLENLKE;GVLWLAWSACYWRDLL;LSNLFTMTVEVKGP;TLEEYPLMIF;VLPIILLLLGAQPSPLSL 5 14.4 0.98385 -0.25526 13.5894 0 13.7357 13.0786 8.28744 13.0836 0 11.8061 0 12.2917 0 11.6672 13.0805 12.4921 13.0219 A0A8I3P6U8 A0A8I3P6U8_CANLF BAG cochaperone 3 BAG3 Canis lupus familiaris (Dog) (Canis familiaris) protein-folding chaperone binding [GO:0051087] SCGWDTRAAAAERSS;TDKNKKSAGNEEDPKT 2 5.9 0.91754 0.11342 0 10.4193 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6V1 A0A8I3P6V1_CANLF Solute carrier family 43 member 1 SLC43A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] APAATFHGHGGTPERRTLLGE;DHKVTGDRFY;LGWGSLLIMLKEEG;TLTNFLLVGFG 4 10.6 0.94892 0.050031 0 0 0 5.27404 0 0 0 0 0 0 0 0 0 7.87055 0 A0A8I3P6V3 A0A8I3P6V3_CANLF Electron transfer flavoprotein beta subunit lysine methyltransferase (ETFB lysine methyltransferase) (Protein N-lysine methyltransferase METTL20) ETFBKMT Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:1904736] mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991] heat shock protein binding [GO:0031072]; protein-lysine N-methyltransferase activity [GO:0016279] LDNPDVVRGKSVL 1 4.9 0.93868 0.059751 0 0 0 5.90771 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P6V8 A0A8I3P6V8_CANLF Actin related protein 10 ACTR10 Canis lupus familiaris (Dog) (Canis familiaris) retrograde axonal transport of mitochondrion [GO:0098958] axon cytoplasm [GO:1904115]; dynactin complex [GO:0005869] AGETGPRCIIPSVIKRAGLPKPIKV;PPLEMMFDVGKAQPP;TGAAKEQS 3 12.6 0.99355 -0.17044 0 0 0 0 0 0 0 8.70539 9.30663 0 0 0 0 10.0755 0 A0A8I3P6V9 A0A8I3P6V9_CANLF Nuclear RNA export factor 2 LOC492024 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] EPEEMEQLKLTMNKRYDV;KTQHDLSSLVVDMWFQTEKM;QPTYISAIRDC;VLPYEKYKK;YVLPYEKYK 5 10.3 0.94448 0.084149 0 0 0 0 0 7.12897 0 0 0 0 0 0 0 0 8.01072 A0A8I3P6W8 A0A8I3P6W8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PDKGRDLSVAGEAEL;TLVTVSGG 2 11.8 0.99079 -0.21018 0 0 8.34966 0 0 0 0 0 9.53469 0 0 0 0 0 0 A0A8I3P6X8 A0A8I3P6X8_CANLF Olfactory receptor OR52AD1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGLDLFFI 1 2.5 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.65889 0 0 0 A0A8I3P6Y5 A0A8I3P6Y5_CANLF Homeobox C11 HOXC11 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal joint morphogenesis [GO:0060272]; metanephros development [GO:0001656]; organ induction [GO:0001759]; proximal/distal pattern formation [GO:0009954] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" STNPSSSGSAHSAAAK;SYGLEPSGKWH 2 8.9 0.98798 -0.48966 0 0 0 9.15368 0 0 10.1288 0 0 0 0 0 0 0 0 A0A8I3P6Z0 A0A8I3P6Z0_CANLF Ig-like domain-containing protein ICOSLG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDSYPVSP;ELRCVFPERHTFDL;GASGGRGQ 3 5.7 1.0018 -1.3094 0 0 0 8.535 9.34671 0 7.28438 0 0 10.5956 0 0 0 9.81325 0 A0A8I3P710 A0A8I3P710_CANLF Growth arrest and DNA damage inducible gamma GADD45G Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634] ALQIHFTLIQAFCCE;PDNVTFCVLAAD;RQGCLTAGVYESAKVLNVDPD;TAGVYESAKVL 4 28.9 0.57143 0.39431 12.2575 0 0 5.68089 0 0 0 12.1778 0 0 12.3194 0 0 6.80206 0 A0A8I3P713 A0A8I3P713_CANLF Transient receptor potential cation channel subfamily C member 4 associated protein TRPC4AP Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] Cul4A-RING E3 ubiquitin ligase complex [GO:0031464] phosphatase binding [GO:0019902] FENQVDMKVAE;SLVILMLARRKERL;SLVILMLARRKERLPLYLRLLQR;TYIFDLFGG;VLHGHNQNCDCS 5 7.5 1.0029 -0.73119 0 0 0 0 4.66948 7.78542 0 0 0 0 6.59583 8.86737 6.85262 0 0 A0A8I3P715 A0A8I3P715_CANLF ATPase family AAA domain containing 2B ATAD2B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GAKAGGSG;MYSRVKRRRKSLRR;PGATLPNGHSSLS;RPIEEDRRKFFQELIL;RSPARRSHIRCLPMNFRAE;SHIRCLPMNFRAED;TMYSELPEEVKCIFRIQY;TNDESSCDIMD;TNDESSCDIMDMD 9 7.2 0.9877 -0.49429 0 9.31338 0 5.19606 0 2.95269 0 0 7.03804 0 0 0 0 0 11.8139 A0A8I3P716 A0A8I3P716_CANLF Pituitary homeobox 2 (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) PITX2 Canis lupus familiaris (Dog) (Canis familiaris) deltoid tuberosity development [GO:0035993]; iris morphogenesis [GO:0061072]; odontogenesis [GO:0042476]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" FPFFNSMNVNPL;GGGGGGSG;PGGGGGGG;PPGGGGGGG;QELEATFQ 5 6.8 1.0029 -1.3768 0 0 10.4113 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P718 A0A8I3P718_CANLF Interleukin 2 receptor subunit gamma IL2RG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] LEQSVDHRNS;PLCGSAQRWS 2 10.9 0.98949 -0.5218 0 0 0 0 0 0 0 8.13103 0 14.9276 0 0 0 0 0 A0A8I3P726 A0A8I3P726_CANLF Fibroblast growth factor receptor (EC 2.7.10.1) FGFR2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007] DAISSGDDEDDTDGSEDF;DVWSFGVLMWEIFTL;SIGISFHSAWLTVLPAPVREKE 3 7.3 0.98503 -0.43968 0 0 0 0 0 0 0 11.4133 0 0 0 0 0 0 9.71125 A0A8I3P734 A0A8I3P734_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCE1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435] ANNEEEEDEEDEYDYDYESLSD;CDDYDALDDKYLCFEDSCQ;DLQLPLSYYYIES;DTKPIVTDYFLMEEK;DYDYESLSDDN;EDEEDEYDYDYESL;EEDEEDEYDYDYESLSD;EEDEEDEYDYDYESLSDDNILED;EEEDEEDEYDYDYESLSDDNI;EEEEDEEDEYDYDYE;GLTSSQVLASESVQ;INSDLPIIISI;KHTAKMLF;LIDLQPLIQ;LRRKVLLKNKKLKAHQTPV;MKLCPRYNSQE;NEEEEDEEDEYDYDYESLSDDN;NNEEEEDEEDEYDYDYESL;NNEEEEDEEDEYDYDYESLSD;PSPDQLRRKVLLKNKKLKAH;QLRRKVLLKNKKLKAHQT;TKKKKKILI;VDYLYFLTRD 23 7.5 0.99961 -2.9124 10.3517 12.5844 8.10533 6.94509 9.14152 8.07146 0 10.4082 8.82114 6.96451 5.75245 0 8.7656 5.36877 7.39215 A0A8I3P736 A0A8I3P736_CANLF MAPK activated protein kinase 3 MAPKAPK3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; macropinocytosis [GO:0044351]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; mitogen-activated protein kinase binding [GO:0051019] DMWSLGVIMYILL;DQVQIKDLKTS;RTGQKCALKDYRMPE 3 9.2 0.99087 -0.19543 0 0 0 10.6925 0 0 0 0 6.79831 0 0 0 0 0 0 A0A8I3P737 A0A8I3P737_CANLF DnaJ homolog subfamily C member 5 (Cysteine string protein) DNAJC5 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; regulation of synaptic vesicle cycle [GO:0098693] chromaffin granule membrane [GO:0042584]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] CCCLCCCFNCCCG;CCCLCCCFNCCCGR;CCLCCCFNCCCG;CCYFCCCLCCC;CCYFCCCLCCCFNC;CCYFCCCLCCCFNCC;CCYFCCCLCCCFNCCC;CLCCCFNCCCGRC;CYFCCCLCCC;CYFCCCLCCCFNCC;CYFCCCLCCCFNCCCGR;CYFCCCLCCCFNCCCGRC;EQFGEENVNTYFVLSSW;GVCGVLTCCYFCCCLCC;GVCGVLTCCYFCCCLCCCFN;GVLTCCYFCCC;GVLTCCYFCCCLC;GVLTCCYFCCCLCCCFN;GVLTCCYFCCCLCCCFNCC;LTCCYFCCCLCCCFNC;SLYHVLGL;TCCYFCCCLCCC;TCCYFCCCLCCCF;TCCYFCCCLCCCFN;TCCYFCCCLCCCFNCCC;TCCYFCCCLCCCFNCCCG;TCCYFCCCLCCCFNCCCGR;VCGVLTCCYFCCCLC;VCGVLTCCYFCCCLCCCFNCCC;VLFGVCGVLTCCYFCCCLCCC;VLTCCYFCCC;VLTCCYFCCCLCCCFNC;VLTCCYFCCCLCCCFNCC;YFCCCLCCCFNCCC;YFCCCLCCCFNCCCG 35 27.3 1.0036 -1.6046 7.87983 9.50678 11.3686 0 6.36455 6.90388 8.64184 10.1076 8.52129 6.75288 0 7.84109 7.25597 9.80012 8.28008 A0A8I3P762 A0A8I3P762_CANLF Transglutaminase 3 STK35 Canis lupus familiaris (Dog) (Canis familiaris) keratinocyte differentiation [GO:0030216] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; protein-containing complex [GO:0032991] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; protein kinase activity [GO:0004672]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; structural molecule activity [GO:0005198] ELALAEFWALTSLKRRHQN;LDQAQVQKPVNVQM;PFVFAEVNADRITWIYDVYNS 3 6.3 0.99072 -0.19507 0 0 0 0 7.65227 7.89779 0 0 0 0 0 0 0 0 9.9641 A0A8I3P793 A0A8I3P793_CANLF Calmodulin like 4 CALML4 Canis lupus familiaris (Dog) (Canis familiaris) myosin II complex [GO:0016460] calcium ion binding [GO:0005509] HKEVDDLF 1 6.7 1.0031 -1.1044 0 0 0 0 0 0 0 8.88643 0 0 0 0 0 0 0 A0A8I3P795 A0A8I3P795_CANLF NHP2-like protein 1 SNU13 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]" box C/D methylation guide snoRNP complex [GO:0031428]; cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; precatalytic spliceosome [GO:0071011]; small-subunit processome [GO:0032040]; U4/U6 x U5 tri-snRNP complex [GO:0046540] RNA binding [GO:0003723] GTGQETTEAGVMTEAD 1 9.8 0.98923 -0.19975 13.2809 0 0 0 0 0 0 0 0 0 13.4658 0 0 0 0 A0A8I3P796 A0A8I3P796_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA4 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] dendrite [GO:0030425]; early endosome [GO:0005769]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; transmembrane-ephrin receptor activity [GO:0005005] GVILEYEVKYY;ICDAVTGSRVYP;VLVVILIAAFVISRRRSKYSK 3 4.7 0.9897 -0.1978 0 0 0 0 0 0 0 0 0 0 0 0 0 8.16294 0 A0A8I3P7B9 A0A8I3P7B9_CANLF Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 CITED1 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; labyrinthine layer development [GO:0060711]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of osteoblast differentiation [GO:0045668]; nucleocytoplasmic transport [GO:0006913]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to interleukin-1 [GO:0070555]; response to interleukin-11 [GO:0071105]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-6 [GO:0070741]; response to interleukin-9 [GO:0071104]; response to lipopolysaccharide [GO:0032496]; response to parathyroid hormone [GO:0071107]; response to type II interferon [GO:0034341]; SMAD protein signal transduction [GO:0060395]; spongiotrophoblast layer development [GO:0060712]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570] cytosol [GO:0005829]; nucleus [GO:0005634] chromatin binding [GO:0003682]; co-SMAD binding [GO:0070410]; LBD domain binding [GO:0050693]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713] EVLMSLVVELGLDRANE;GVATNGTKASGA 2 13.1 0.9912 -0.1855 4.74916 0 0 0 0 0 0 0 10.9046 0 0 0 0 0 0 A0A8I3P7D3 A0A8I3P7D3_CANLF Striatin interacting protein 2 STRIP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytosol [GO:0005829] ALKVKQAMLQLYVL;APHFPIKKVLLLLWKVVMQL;FHYSYELWLEREVFSQPICWEELL;FPIKKVLLLLWKV;LEFTTNRRCFE;QLYVLKLLKIQ 6 9.8 0.988 -0.37517 0 0 4.91586 4.74276 0 2.96833 0 9.44917 10.0895 0 0 0 9.63501 0 0 A0A8I3P7D5 A0A8I3P7D5_CANLF Fibrous sheath interacting protein 2 FSIP2 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288] sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] CPGVAPDD;DKISNFVYDQFMGKYRSSDIQ;DSHLLTSFERCTKIS;EDSILSSDSSSFCSTCSE;EDTTRLSDQQPMTDPT;FPPIDKETVDKI;FYSLPSITEDSK;GFNLNDPYCRLLENQYKS;IVSQLMKSVTAEISQSNIN;KESEGSDIFVENI;KIVKNVLDSSFR;KVISAISKHKILFTI;LEDIIRRLLSQLIPLPNKAS;LENKCLQYSPSQVGKDLVQMV;LSHSFLEDIIRRLLSQLI;LSINAKNPTSARLP;LVEEALALFLAKIVR;LVPSSFSSPQADNI;NLGLTPKSVFLLN;PSASSSILDRK;QAESNDMENEKYKLMMIAENVLTEI;QEVSGNQLQNYFSGELTPHQC;QFTKGNTCFEY;RKDILRRLKKGGYITSNN;SSFCSTCSEEFTYGSYTSATT;STKSSQSL;TVTMVLQELYATSNH;VINEIFQHQLN 28 6.4 0.98383 -0.24209 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14.579 A0A8I3P7E4 A0A8I3P7E4_CANLF ADP-ribosylation factor-like protein 6-interacting protein 4 ARL6IP4 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607]; nucleolus [GO:0005730] HKDKKRRKKKRKRKKQLKKKGKEK;KHKDKKRRKKKRKRKK;KKKRKRKKQLKKK;KKKRKRKKQLKKKGKEKAK;KKRKRKKQLKKKGK;KKRRKKKRKRKK;KRRKKKRKRKKQ;KRRKKKRKRKKQLKKK;RGKHKDKKRRKKKRKRKKQLK;RKKKRKRKKQLKKKGK;RRKKKRKRKKQLKKKG 11 12.6 0.39597 0.55602 4.21521 0 6.68426 0 6.41787 3.08038 0 7.74759 0 4.51336 7.89415 0 3.74814 3.51954 7.07703 A0A8I3P7E6 A0A8I3P7E6_CANLF Dynein light chain roadblock-type 1 MAP1LC3A Canis lupus familiaris (Dog) (Canis familiaris) ADRCKEVQQIRDQHPSKI;EPAQTSAES;NPTTTQYANLMHNF 3 18.6 0.98904 -0.52229 0 0 0 0 9.47778 0 0 0 0 0 0 0 4.29668 3.56511 8.34939 A0A8I3P7F5 A0A8I3P7F5_CANLF Uncharacterized protein JRKL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DTSNLPVSYFSQ;EGLDFDEEDISM;NLPVSYFSQKGAWMDLS 3 6.1 0.99454 -0.15475 10.4774 0 0 0 0 7.80387 0 0 0 0 9.24928 0 0 0 0 A0A8I3P7F9 A0A8I3P7F9_CANLF Gamma-aminobutyric acid type B receptor subunit 1 GABBR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled GABA receptor activity [GO:0004965] NWFKTYDPS;SSERRAVY;TEAVEGHITTEIVMLNPAN;VEKLTKRLK;VSVLSSLGI;VYIGALFPMSGGWPGG 6 8.1 1.0015 -2.6541 0 0 0 0 0 0 0 0 0 0 8.89827 0 5.81311 0 13.9847 A0A8I3P7G1 A0A8I3P7G1_CANLF Ribosomal RNA processing 1 RRP1 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] "nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]" DLLNEVDSQEEEEDDDDEDNE;DSQEEEEDDDDEDNED;EDDDDEDNEDGMS;EDDDDEDNEDGMSEDDE;EDDDDEDNEDGMSEDDECKQ;EEEDDDDE;EEEDDDDEDNEDGMSEDDEC;EVDSQEEEEDDDDEDNE;LNEVDSQEEEEDDDDEDNEDGM;QEEEEDDDDED;VDSQEEEEDDDDED 11 7.6 0.85066 0.15035 0 5.62314 0 0 8.30172 7.74376 5.1311 5.19554 0 0 0 0 4.88215 0 0 A0A8I3P7G2 A0A8I3P7G2_CANLF A-kinase anchoring protein 10 AKAP10 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase A binding [GO:0051018] AGPSHVAI;DAAKPIPITEAMRNDIIAKICGEDG;GKEQEKTSDVKSI;LVACRNNPS;VRLEIESN 5 10.4 1.0019 -1.8183 0 6.5338 0 0 4.15405 0 0 0 0 5.89084 0 0 9.57847 6.46836 0 A0A8I3P7G4 A0A8I3P7G4_CANLF T cell leukemia homeobox 1 TLX1 Canis lupus familiaris (Dog) (Canis familiaris) animal organ development [GO:0048513] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGA;GGGGGGGG;GPASRLQDGEYGLG;PGGGGGGG;PISFGIDQILNS;VGGAYAYGGGGPAAGAGAG 6 18.7 0.86509 0.16109 0 0 0 0 0 0 0 8.95111 0 0 0 0 0 9.67391 0 A0A8I3P7G7 A0A8I3P7G7_CANLF Uncharacterized protein NXT2 Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913] cytosol [GO:0005829]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654] PEQAASGSLMATSVDFKTHVDQ 1 11.1 0.97349 0.046802 0 0 0 0 0 0 0 0 0 0 9.88593 0 0 0 0 A0A8I3P7H0 A0A8I3P7H0_CANLF Transcription initiation factor TFIID subunit TAF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] transcription factor TFIID complex [GO:0005669] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025] DDEEDAGSDEEGDNP;DEDDYDADCEDI;DEDDYDADCEDIDC;EDDEEDAGSDEEGDNPFS;EGYDDEEEDG;HSDYDEDDYDADC;HSDYDEDDYDADCE;KEDKLARLEKAI;NYYKRKPG;PLCHSDYDEDDYDADC;PVESKFSQ;QPLCHSDYDEDDYDADC;QPLCHSDYDEDDYDADCE;SQVHLSEDEEDSEDFHSIAGD;VLSQVHLSEDEED;VLYEDLLMSEGEDDEEDAG 16 5.9 0.99086 -0.2752 0 0 0 0 0 0 0 0 0 7.99396 0 0 0 0 0 A0A8I3P7H4 A0A8I3P7H4_CANLF Fuzzy planar cell polarity protein FUZ Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; positive regulation of cilium assembly [GO:0045724]; vesicle-mediated transport [GO:0016192] PLDGERAGGATMGWGGRGG;VGATAVAA;VGSLPPQAA 3 7.3 1.0025 -1.0202 0 0 4.19298 0 9.71925 0 0 0 0 0 8.28258 0 0 0 0 A0A8I3P7J6 A0A8I3P7J6_CANLF Matrilin 3 MATN3 Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023] calcium ion binding [GO:0005509] AKLDDILGKL;VGVDRADMESL 2 4.7 1.0017 -0.91196 0 0 0 0 0 0 0 0 0 0 0 0 0 8.59044 0 A0A8I3P7K0 A0A8I3P7K0_CANLF ADP-ribosylation factor Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139]; postsynaptic density [GO:0014069] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGGQDKIRPLWRHYFQNTRGLIF 1 12.7 0.97986 0.046263 0 0 0 0 0 0 0 0 0 0 0 0 0 9.2517 0 A0A8I3P7K3 A0A8I3P7K3_CANLF Cortexin domain containing 2 CTXND2 Canis lupus familiaris (Dog) (Canis familiaris) LFLIVMIFRCAKLVKNP 1 30.9 0.97693 0.046227 0 0 0 0 0 0 0 0 10.7651 0 0 0 0 0 0 A0A8I3P7K6 A0A8I3P7K6_CANLF Ladybird homeobox 1 LBX1 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; glutamatergic neuron differentiation [GO:1905962]; heart looping [GO:0001947]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of glutamatergic neuron differentiation [GO:0120007]; neuron fate determination [GO:0048664]; spinal cord motor neuron differentiation [GO:0021522] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" AAGGGGGG;DRDQIAQQLGL;KKRRKSRTAFTNH 3 11.4 0.92476 0.095052 0 0 0 0 0 0 0 0 0 0 0 0 9.4528 8.91961 0 A0A8I3P7K7 A0A8I3P7K7_CANLF Serpin domain-containing protein SERPINE2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] GVNGVGKVLKKINKAIGSKKN;LVAAVTLPSVCSQFNPLS;REPLGVPCL 3 9.9 0.99706 -0.58817 0 0 0 7.62768 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P7P3 A0A8I3P7P3_CANLF 5-methylcytosine rRNA methyltransferase NSUN4 (5-methylcytosine tRNA methyltransferase NSUN4) (NOL1/NOP2/Sun domain family member 4) NSUN4 Canis lupus familiaris (Dog) (Canis familiaris) RNA methylation [GO:0001510] mitochondrion [GO:0005739] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] GVMDYYLMDAAS;LQTGCCRNLAAND 2 7.5 0.8385 0.19783 11.2325 0 0 0 0 0 0 0 0 0 11.6397 0 0 8.82703 0 A0A8I3P7P4 A0A8I3P7P4_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST6 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] LCTLPGRGPPAARAPLPAP 1 5.6 0.95421 0.04941 0 0 0 0 0 4.24473 0 0 0 0 0 0 0 0 0 A0A8I3P7P5 A0A8I3P7P5_CANLF ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) PFKL Canis lupus familiaris (Dog) (Canis familiaris) "fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]" 6-phosphofructokinase complex [GO:0005945] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872] DFEHRMPREQWW;GLVGSIDNDFCGTDMTIGTDSA;IDAITTTAQSHQ;KEVQKAMDEKRFDEAIQLRGRSFE;QWWLNLRLMLKMLAH;VRGPGGGST 6 10.8 1.002 -1.2647 11.2408 5.83094 0 0 0 0 0 0 0 0 0 0 0 0 9.06848 A0A8I3P7P7 A0A8I3P7P7_CANLF Kinectin 1 KTN1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] kinesin binding [GO:0019894] EVLAKQKREQKLIPTKTDKK;GVSFLSGS;LQQEEVQKKNAEQ;QLQEAERRWEEVQSYIRKRTAEHEA;VLDKREVIDL;VLEHKLKEADEMH 6 6.7 1.0031 -1.1044 0 0 0 0 5.78505 0 0 0 0 0 0 0 0 0 0 A0A8I3P7Q1 A0A8I3P7Q1_CANLF Oxidoreductase HTATIP2 HTATIP2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525] nuclear envelope [GO:0005635] GAGEVEARVEELQFD 1 7.7 0.99491 -0.12919 0 0 0 0 9.51325 0 0 0 0 0 0 0 8.75031 0 0 A0A8I3P7Q4 A0A8I3P7Q4_CANLF Lysosomal-associated transmembrane protein 4A LAPTM4A Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] LLALDSSC 1 3.4 0.98552 -0.25824 0 0 0 0 0 0 0 0 0 0 7.96029 0 0 0 0 A0A8I3P7Q5 A0A8I3P7Q5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APVEARDDV 1 8 1.0035 -0.80421 0 0 8.71146 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P7S0 A0A8I3P7S0_CANLF Solute carrier family 12 member 6 SLC12A6 Canis lupus familiaris (Dog) (Canis familiaris) cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573] plasma membrane [GO:0005886]; synapse [GO:0045202] potassium:chloride symporter activity [GO:0015379] ISFFPSNVEQ;LDLVAPILSMFFLMC 2 2.6 0.99761 -0.10231 8.99387 0 0 8.93634 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P7S4 A0A8I3P7S4_CANLF Zinc finger and BTB domain containing 11 ZBTB11 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; nucleoplasm [GO:0005654] chromatin insulator sequence binding [GO:0043035] ESYRAILRYLTNEREPYAPGT;KFTQLREYRRHMNNHEGVKPFECL;RDYKCPLCK;RKTFAELE 4 5.9 1.0035 -1.0561 0 0 0 9.68078 0 0 0 0 0 0 0 0 0 0 7.36851 A0A8I3P7S7 A0A8I3P7S7_CANLF Even-skipped homeobox 1 EVX1 Canis lupus familiaris (Dog) (Canis familiaris) embryo development ending in birth or egg hatching [GO:0009792]; interneuron migration [GO:1904936]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spinal cord interneuron axon guidance [GO:0097377] axon [GO:0030424]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" SPVGLGAA 1 2 1.0045 -1.1044 0 0 0 0 0 0 11.2505 0 0 0 0 0 0 0 0 A0A8I3P7U2 A0A8I3P7U2_CANLF FAM3 metabolism regulating signaling molecule D FAM3D Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of insulin secretion [GO:0046676] extracellular space [GO:0005615] carbohydrate binding [GO:0030246] KYDGWPELLELEGCV;NLVIMSPVKNNVG;SAAKKIRVVK 3 17 0.99118 -0.54553 0 0 0 0 0 0 0 9.77462 0 0 0 0 0 8.75672 0 A0A8I3P7V8 A0A8I3P7V8_CANLF Cytosolic arginine sensor for mTORC1 subunit 1 (GATS-like protein 3) CASTOR1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] PAIATTLI 1 2.7 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 8.45022 8.20984 0 0 0 A0A8I3P7X1 A0A8I3P7X1_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) PEX10 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein polyubiquitination [GO:0000209]" peroxisomal membrane [GO:0005778] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AGAKRWLECRREVELLSDVAYF;EVELLSDVAYFGLT;VHLALSVGLQLYGFRQRQR 3 13.5 0.98671 -0.45871 0 0 0 0 0 0 0 8.22752 0 0 0 0 10.2204 0 0 A0A8I3P7Y9 A0A8I3P7Y9_CANLF Sulfotransferase (EC 2.8.2.-) SULT6B1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] NPKDTAVSFFHFHN;SWGSYFDFAINWNKHLDD;THLHYDKLPGS 3 14.2 0.99303 -0.19136 7.81622 0 0 0 0 0 0 0 0 9.38578 0 0 0 0 0 A0A8I3P7Z2 A0A8I3P7Z2_CANLF Mono-ADP ribosylhydrolase 2 MACROD2 Canis lupus familiaris (Dog) (Canis familiaris) LSTIKEWLATN 1 2.6 0.98417 -0.25512 0 0 0 7.28753 7.54048 7.60006 0 0 0 0 0 8.17138 0 0 0 A0A8I3P805 A0A8I3P805_CANLF Pentraxin 4 PTX4 Canis lupus familiaris (Dog) (Canis familiaris) FREGYEIPP;VPGGAILT 2 3.7 1.0016 -1.4089 0 0 0 0 0 0 0 0 0 8.41595 0 10.1638 0 0 0 A0A8I3P814 A0A8I3P814_CANLF HORMA domain-containing protein MAD2L1 Canis lupus familiaris (Dog) (Canis familiaris) LVTTDPELMKYLNNVVEQ 1 8.8 0.96974 0.048313 0 0 0 0 0 0 0 0 6.94052 0 0 0 0 0 0 A0A8I3P820 A0A8I3P820_CANLF Allograft inflammatory factor 1 like AIF1L Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; ruffle assembly [GO:0097178] actin filament [GO:0005884]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] SEVTGGVS 1 5.3 0.98979 -0.26584 0 0 10.878 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P824 A0A8I3P824_CANLF Glutamate metabotropic receptor 2 GRM2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] RRLYKDFVL;VSLSGSVVLGCLFA;WLAFLPIFYVTSSDYRV 3 6.7 0.99411 -0.13134 15.913 15.2029 0 12.6979 15.071 0 0 15.5944 15.6342 0 12.5982 0 13.9929 15.3202 0 A0A8I3P836 A0A8I3P836_CANLF Heparanase (EC 3.2.1.166) HPSE Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160]; establishment of endothelial barrier [GO:0061028]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin metabolic process [GO:0030202]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein transmembrane transport [GO:0071806]; vascular wound healing [GO:0061042] extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654] heparanase activity [GO:0030305]; syndecan binding [GO:0045545] FEPLPDYWLSLLFKK;IFGLNALLRTANL;IGQPRGKTVP;KARLPPPPPLLLLLLGP;PPLLLLLL 5 10.1 0.98795 -0.46089 0 0 8.57947 0 4.69883 0 0 0 0 4.27038 0 0 0 0 0 A0A8I3P839 A0A8I3P839_CANLF Zinc finger protein 621 ZNF621 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECRKCGRYFSRMADFQGC 1 4.3 0.98352 -0.25658 0 10.7512 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P857 A0A8I3P857_CANLF CDKN2A interacting protein CDKN2AIP Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647] granular component [GO:0001652]; nucleoplasm [GO:0005654] p53 binding [GO:0002039]; RNA binding [GO:0003723] EALKLFLKKKVVVKI;FLKKKVVVKI;GLTSKTSSE;KAVASREALKLFLKKK;KLFLKKKVVVKICKRKYRG;LDVFFVPL;LKKKVVVKI;LKKKVVVKICKRK;LKLFLKKKVV;SSTCTGSS 10 9.2 0.99951 -2.9144 0 3.34922 2.88591 4.00504 0 0 7.46695 7.45162 5.26191 0 0 0 0 0 11.9919 A0A8I3P859 A0A8I3P859_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK39 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ASGCDGSE;LEKCQTSMDELLKEIQ;PGSSGHLHKTEDGDWEWSDDEM;PKKKKKKIKDFIYL;PYFPKKKKK 5 10.9 1.0018 -0.74345 0 0 0 0 0 0 0 0 4.24679 5.31517 0 0 0 0 0 A0A8I3P867 A0A8I3P867_CANLF Shiftless antiviral inhibitor of ribosomal frameshifting SHFL Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932] ribosome binding [GO:0043022]; sequence-specific mRNA binding [GO:1990825] EDLDNLILEDLK;RKRYEPVPCDKMWGVAEFHCPKCR 2 12.6 0.98602 -0.23588 0 8.24122 0 0 0 0 0 0 0 0 0 0 0 0 10.7295 A0A8I3P869 A0A8I3P869_CANLF Myosin light chain 4 MYL4 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048] A band [GO:0031672]; myosin II complex [GO:0016460] actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509] EQGTYEDFV;LPVTVFAWPRRPQ 2 8.9 0.93816 0.059565 0 0 0 6.67384 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P872 A0A8I3P872_CANLF Uncharacterized protein TMEM69 Canis lupus familiaris (Dog) (Canis familiaris) ETLSLKTCHQQKFSP;FPVYMRKTQYYHTSP;LSFLGGIRWGF;NWFKALKIVVTLVALFSFIITLLVK 4 26.5 1.0028 -0.72257 6.55102 0 0 0 9.34618 0 0 10.4366 0 0 0 0 0 0 0 A0A8I3P874 A0A8I3P874_CANLF Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Large fibroblast proteoglycan) (PG-M) VCAN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; photoreceptor outer segment [GO:0001750] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] AVFSSVERLHTTSASKPSPAP;CELDFDECHSNPCRN;DSTPEERVPPVTSVEGQVIYAAT;DVTTTPSVQYI;EEECENQDARL;EITLYHSEEDEEEDEEC;FSEESSGDAATDQES;HRRTWDAAERECRLQ;IPSPSATVTPETEEPKS;LDYTDLGS;LEPSEDESNPKLLE;PCRNGATCVDGFNTF;SAEGSGEE;SEEDEEEDEECT;TKPIYVDIL;TLYHSEEDEEEDEECTNAT;VEGQVIYAATE;VLLHGPLSTV;VSGEQNHGPEI;VTRTPSIGPTVSLSP;VTSAPKPSDLLYE;VTVSKWAWDEDDTT 22 7.7 1.0031 -2.1277 0 14.9439 11.3583 0 0 5.40688 0 4.2228 10.1955 10.6063 10.443 10.9 0 10.7997 9.46152 A0A8I3P876 A0A8I3P876_CANLF Zyxin ZYX Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160]; cellular response to type II interferon [GO:0071346]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] adherens junction [GO:0005912]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; stress fiber [GO:0001725] metal ion binding [GO:0046872] APSPAPKFSPVTPKFTPV;DQANRPHCVPDYHKQYAPRCSVCEG;EEIFPSPPPPPLD;GAPGPLSLKEVQELE;GGSKAKAG;GPPAPSPAPKFSPVTPKFTPVAS;KVHVNKAARGR;SLKEVQELE;SPVTPKFTPVAS;TPKFTPVAS 10 16 1.0037 -1.0689 0 0 0 0 0 0 12.3033 0 0 0 0 0 9.03988 0 0 A0A8I3P8D6 A0A8I3P8D6_CANLF Ribosome biogenesis regulatory protein RRS1 Canis lupus familiaris (Dog) (Canis familiaris) "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; mitotic metaphase chromosome alignment [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit biogenesis [GO:0042273]" "condensed nuclear chromosome [GO:0000794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" 5S rRNA binding [GO:0008097] KMNSGPPRLGGK 1 3.3 0.95359 0.05044 0 0 0 0 0 0 0 8.54639 0 0 0 0 0 0 0 A0A8I3P8E7 A0A8I3P8E7_CANLF C2H2-type domain-containing protein SLC2A4RG Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] GGGKPGGP;GGKPGGPG;PRKRKSSVQVL;RPLGSCSS;VGGGFAGP 5 10 1.0035 -1.5988 0 0 0 0 0 10.0593 10.3231 0 0 0 0 0 0 0 9.15596 A0A8I3P8F6 A0A8I3P8F6_CANLF Carbonic anhydrase 14 CA14 Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] DHWPASHPECGSNAQSPIDIQT;LLAVYFIARKIRKKRLGNRKTVV;QTDSVTFDPELPALQLQ;VGEAKNPVYEHI 4 21.4 0.85685 0.1898 0 8.31845 0 5.12135 0 0 0 10.9784 0 0 0 0 0 0 9.2191 A0A8I3P8F7 A0A8I3P8F7_CANLF Spermatogenesis associated 13 SPATA13 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] FWHTFNKLTPF;NGGCSSSHCGEAEAQEA;QVLEASNKDWWWGRNEDKEAWFPAS 3 4.3 0.99155 -0.54518 0 0 0 0 0 0 0 0 0 0 0 10.4289 0 0 0 A0A8I3P8G7 A0A8I3P8G7_CANLF Oxoglutarate receptor 1 OXGR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] NEPLDNFANASDF 1 3.9 0.98849 -0.22503 0 0 0 0 0 0 0 0 0 0 8.89564 0 0 0 0 A0A8I3P8G9 A0A8I3P8G9_CANLF Septin-4 SEPTIN4 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157] cell division site [GO:0032153]; dendrite [GO:0030425]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; septin complex [GO:0031105]; septin ring [GO:0005940]; sperm annulus [GO:0097227]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] DIEEKGVRLRLTIVDTPG;DPETERLIRE;FPDCDSDEDE;PQPSDSQQYFSAS;VSEAWDMDRSLGWQGSSVPED 5 13.3 1.0037 -0.81587 0 0 0 0 6.93239 0 9.37215 0 0 0 0 0 9.09048 0 0 A0A8I3P8H4 A0A8I3P8H4_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1" SMARCD1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SWI/SNF complex [GO:0016514] transcription coregulator activity [GO:0003712] DLYGPDNHLVEWHRTATTQ;LSFARDPQGFINDWLQ;QEALKRPIKQKRKLRIF;THKLQDPHEREFVICDKYLQ 4 14 0.99531 -0.15343 0 0 0 0 0 0 10.789 0 0 0 0 0 0 0 0 A0A8I3P8H6 A0A8I3P8H6_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNTL6 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation via threonine [GO:0018243] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] EIWGGEQYEISFKVWMCGG;FMVALIFLPNIGLW;QTFPLGLGDGQFYAWTDGLRRKDW;RVAETWMDEFAEYIYQ;YIYQRRPEYR 5 13.1 1.0039 -0.82221 6.83693 0 0 0 0 0 0 0 0 0 0 4.61982 4.92941 0 8.07286 A0A8I3P8I5 A0A8I3P8I5_CANLF Kinesin-like protein KIF23 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ESSRSHSVFNIKLVQAPLDADGD;FRNEVELEEDHC;NDEQTLPRLIEALEKRHYLRQ;TIYEEDKRTL 4 7.4 0.98763 -0.46741 0 0 0 0 0 8.34744 0 9.06059 0 8.71538 0 3.38612 8.09434 0 0 A0A8I3P8I6 A0A8I3P8I6_CANLF Cilia-and flagella-associated protein 96 CFAP96 Canis lupus familiaris (Dog) (Canis familiaris) 9+0 non-motile cilium [GO:0097731]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881] KFVFDFQTLQNNI;SPGKKAGG 2 6.4 0.99498 -0.18914 0 5.29638 0 0 0 0 0 0 0 0 0 0 16.3035 0 0 A0A8I3P8J0 A0A8I3P8J0_CANLF B9 domain-containing protein 1 B9D1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; MKS complex [GO:0036038] PEYDDLYCKYCFV;PTAGLEEGISQ 2 16 0.99713 -0.11065 0 0 10.5225 0 0 0 0 0 0 8.49502 0 11.1593 0 0 7.94251 A0A8I3P8J7 A0A8I3P8J7_CANLF AMMECR nuclear protein 1 AMMECR1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] PYALKDSRFPPMT;VLYCHLYGYQQPRTPRFTNEPYA 2 11.2 0.99082 -0.21104 0 0 0 0 0 0 10.8865 0 0 0 0 0 0 0 0 A0A8I3P8K1 A0A8I3P8K1_CANLF heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17) GLCE Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; protein homodimerization activity [GO:0042803] LFFGSGGS;PTKIMPKKVVRLIAKGK 2 3.5 0.98968 -0.2632 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.96723 A0A8I3P8L7 A0A8I3P8L7_CANLF Uncharacterized protein MYRIP Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] actin cytoskeleton [GO:0015629]; exocyst [GO:0000145]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; synapse [GO:0045202] actin binding [GO:0003779]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein kinase A binding [GO:0051018]; small GTPase binding [GO:0031267] AASSGLSP;EAGHRARL;NERKSTTKDLMEPTLE;PSTLWRSQSSFSLP;RCADCKFNVCKSCC;VINATEELIAESAGP 6 8.8 1.0033 -1.9374 0 9.37117 10.5927 0 0 0 9.08813 0 0 0 0 0 0 0 0 A0A8I3P8M7 A0A8I3P8M7_CANLF Metallo-beta-lactamase domain containing 2 MBLAC2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] beta-lactamase activity [GO:0008800]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816] SLGDGIFWIQ;TVMHMPGHSRGSICLHDK 2 10 1.0031 -0.89258 0 0 0 6.85512 5.17528 0 0 0 0 0 6.25303 0 0 0 0 A0A8I3P8N4 A0A8I3P8N4_CANLF Gamma-aminobutyric acid type A receptor subunit gamma3 GABRG3 Canis lupus familiaris (Dog) (Canis familiaris) "gamma-aminobutyric acid signaling pathway [GO:0007214]; synaptic transmission, GABAergic [GO:0051932]" chloride channel complex [GO:0034707]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; postsynapse [GO:0098794]; synaptic membrane [GO:0097060] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] AADQKSWR;AECQLQLHNFP;DCQSFFCCYEECKSGSWRK;TVIDVDIY;YFELSRRMGY 5 12 1.002 -0.91042 0 0 8.69759 0 0 0 0 0 7.10255 9.88608 8.34948 0 0 0 6.66917 A0A8I3P8N5 A0A8I3P8N5_CANLF Olfactory receptor family 51 subfamily A member 18 OR51A18 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLVFPFPFILKRLRFC;SLHEPMYYFLSM 2 8.9 0.95602 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 8.37908 0 0 A0A8I3P8N7 A0A8I3P8N7_CANLF Myelin expression factor 2 MYEF2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] mRNA binding [GO:0003729] NRVFISNIPYDMKW;REKVGEVTYVEL;VGWKKLKEVFSIAGTVK 3 7.9 0.98639 -0.3897 0 10.7837 0 0 0 0 0 0 0 0 0 0 0 10.0447 0 A0A8I3P8N9 A0A8I3P8N9_CANLF Zinc finger FYVE domain-containing protein ZFYVE9 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; early endosome membrane [GO:0031901] metal ion binding [GO:0046872] AEILGTSELLNMTEHFSD;DFSTMDTPAANSLPNCDSYGM;EDGMTKLGLRVTLD;EGEDHCANGQDYSLNP;ENYESGISSRPCLAL;FSDSQDMTNWK;IYIQWVDDDKNVN;LGENSTTNVC;PTPPYLFGILI 9 9.5 1.0037 -1.1076 0 0 10.5085 10.2133 0 0 8.3637 0 9.78514 0 0 10.2704 10.0585 10.0557 10.1421 A0A8I3P8P3 A0A8I3P8P3_CANLF Neuropilin NRP2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; axon guidance [GO:0007411] membrane [GO:0016020] heparin binding [GO:0008201]; metal ion binding [GO:0046872]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor receptor activity [GO:0005021] GKHCGNIAPPTIISS;IDEEATECGENCSFEDDKDLQLPS;LTFHTDMAVAKDGFSA;LVSSRSGWFP;PIDEEATECGENC;SLNGRDWEYIQ;VPVQPIPAYWYYVMA 7 10.2 0.95017 0.053889 0 0 0 0 0 0 0 6.9438 0 0 0 0 0 0 0 A0A8I3P8Q9 A0A8I3P8Q9_CANLF Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) ARHGAP26 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925] GTPase activator activity [GO:0005096] DICAEWEIKTITSA;DLDVLKPARPKSLTPF;LFTFYHHGYELAKDFSDFKTE;VESLMKKMKENPLEHKTISPYTME 4 11.7 0.95507 0.049233 0 0 0 0 0 0 0 0 0 0 8.15553 0 0 0 0 A0A8I3P8R4 A0A8I3P8R4_CANLF "Arginine-hydroxylase NDUFAF5, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5)" NDUFAF5 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981] matrix side of mitochondrial inner membrane [GO:0099617] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] DLQGMGESN 1 2.6 0.99679 -0.11081 0 9.22925 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P8R6 A0A8I3P8R6_CANLF Ankyrin repeat and SOCS box containing 5 ASB5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GADVQKGKYWDTPLHAAAQQS 1 7.6 0.95391 0.050482 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.01603 A0A8I3P8S0 A0A8I3P8S0_CANLF Thyrotropin-releasing hormone receptor (Thyroliberin receptor) LOC485909 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] thyrotropin-releasing hormone receptor activity [GO:0004997] LDFALFYALPLGLATVFYVLI 1 5.7 0.97424 0.047166 0 0 0 0 0 0 0 0 0 5.17648 0 0 0 0 0 A0A8I3P8S6 A0A8I3P8S6_CANLF Glyceraldehyde 3-phosphate dehydrogenase catalytic domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] cytosol [GO:0005829] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365] TVPSKKKKKRQKKI;YTVPSKKKKKRQKKI 2 7 0.91614 0.11464 0 5.45052 0 0 0 0 0 0 3.72247 0 0 0 0 0 0 A0A8I3P8T7 A0A8I3P8T7_CANLF Catenin delta 1 CTNND1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] TNTAGCLR 1 0.9 0.98921 -0.26592 0 0 0 0 0 0 0 0 11.2786 0 0 0 0 0 0 A0A8I3P8U0 A0A8I3P8U0_CANLF Mitochondrial transcription termination factor 3 MTERF3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] double-stranded DNA binding [GO:0003690] LELSVKKTRDLVVRLPRL;PPRPAAALAALAAAPGPGGRDPG;RGGASGGG;VPRRRAAGGGRRAAGAGAC 4 9.1 0.98525 -0.43676 0 0 0 9.80256 0 0 3.68381 0 0 0 0 0 0 0 0 A0A8I3P8U2 A0A8I3P8U2_CANLF Tyrosine-protein kinase (EC 2.7.10.2) ZAP70 Canis lupus familiaris (Dog) (Canis familiaris) beta selection [GO:0043366]; calcium-mediated signaling [GO:0019722]; immune response [GO:0006955]; negative thymic T cell selection [GO:0045060]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive thymic T cell selection [GO:0045059]; T cell receptor signaling pathway [GO:0050852] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; T cell receptor complex [GO:0042101] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784] AHERMPWYHSSL;EQGKRMECP;MHQLDNPYIVRL;RMRKKQIDVAIKVL;VEQRMRAYYYSV 5 9.6 1.0043 -1.0883 0 0 9.01243 0 0 8.35878 0 0 5.39376 11.1268 0 0 10.2734 0 7.47371 A0A8I3P8U4 A0A8I3P8U4_CANLF Olfactory receptor LOC119869077 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LRNKEIKDALKRCKKRVIFPLLQL 1 8.1 0.97135 0.041303 0 0 0 0 0 0 6.25963 0 0 0 0 0 0 0 0 A0A8I3P8U6 A0A8I3P8U6_CANLF Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) CLP1 Canis lupus familiaris (Dog) (Canis familiaris) "cerebellar cortex development [GO:0021695]; global gene silencing by mRNA cleavage [GO:0098795]; mRNA 3'-end processing [GO:0031124]; RISC complex assembly [GO:0070922]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytosol [GO:0005829]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736] LVYHFGSTTPGTNIKLYNKIT;YFYGFRGCFYPH 2 7.8 0.93585 0.098287 0 0 0 0 0 0 0 0 0 0 0 14.1241 0 0 0 A0A8I3P8V1 A0A8I3P8V1_CANLF Engulfment and cell motility 2 ELMO2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; apoptotic process [GO:0006915]; cell motility [GO:0048870]; phagocytosis [GO:0006909] SH3 domain binding [GO:0017124] DPNDQAQRDIIFELRRIAFDAES;HYGDLDDNPQGEVTFE;IVSWDMVSITFI;PPIVELREKIQPEI;RRRQERFWYCRLALNHKVLHYGD;VADIKAIV 6 13.4 1.002 -1.3032 12.7931 12.2231 9.08881 0 0 0 12.2301 13.6856 12.1858 3.88792 0 1.87287 10.5385 0 9.76588 A0A8I3P8V7 A0A8I3P8V7_CANLF RNA polymerase II subunit D POLR2D Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase II promoter [GO:0006367] "cytosol [GO:0005829]; nuclear speck [GO:0016607]; RNA polymerase II, core complex [GO:0005665]" nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369] PETAEESKALIPSLEGRFEDEEL 1 16.2 0.97371 0.046824 10.2992 0 0 0 0 0 0 0 0 0 0 0 3.19265 0 0 A0A8I3P8W4 A0A8I3P8W4_CANLF Kinesin family member 16B KIF16B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; phosphatidylinositol binding [GO:0035091] IHLFIKDSIYLF;KGPICLRL;REKRKSGL;TQAKFDSEMP;WDEASFRTEVSY 5 3.6 0.99197 -0.54019 0 9.07874 0 10.8225 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P8W7 A0A8I3P8W7_CANLF MICOS complex subunit LOC102152929 Canis lupus familiaris (Dog) (Canis familiaris) cristae formation [GO:0042407] MICOS complex [GO:0061617] PPGFMGPA 1 4 0.98949 -0.26592 10.0792 0 0 0 0 0 0 0 10.0583 0 0 0 0 0 0 A0A8I3P8X2 A0A8I3P8X2_CANLF PCI domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) eukaryotic translation initiation factor 3 complex [GO:0005852] translation initiation factor activity [GO:0003743] MLTQATMICTQET;TERFFKNTPW 2 6.7 0.98753 -0.46589 0 0 0 0 0 0 0 9.90977 0 0 10.196 0 0 0 0 A0A8I3P8X7 A0A8I3P8X7_CANLF separase (EC 3.4.22.49) ESPL1 Canis lupus familiaris (Dog) (Canis familiaris) homologous chromosome segregation [GO:0045143]; meiotic spindle organization [GO:0000212]; mitotic sister chromatid segregation [GO:0000070]; proteolysis [GO:0006508] centrosome [GO:0005813]; nucleus [GO:0005634] cysteine-type endopeptidase activity [GO:0004197] EGIERDRRAQ;HDLYIYAGHGAG;HSARTLAPEDIQTLA;LAAKPLQALEV;LLLLQVAQV;LNEADADFL;PAQEASRLQELLQECGWK;SSAALAVHGSLE;TERLTQALQ;VLSQGVDPRNTFYVLNPHNNLSSTE 10 6 1.0029 -2.1106 9.40627 12.9364 0 0 8.26875 0 0 9.98556 10.2584 14.6977 10.6183 8.52474 0 0 0 A0A8I3P8Y4 A0A8I3P8Y4_CANLF Vacuolar protein sorting-associated protein 41 homolog VPS41 Canis lupus familiaris (Dog) (Canis familiaris) endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623] clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] EELEDRPELQH;EQETESLEESTDES;GMEIPNLRDSL;IVSQFETEFYIS;MIMEELHDVD;TVRGFQENECRDYHL 6 8.8 0.98767 -0.36213 14.074 0 0 8.72717 0 11.2346 14.0099 7.50295 0 0 0 0 10.9726 0 0 A0A8I3P8Z4 A0A8I3P8Z4_CANLF V(D)J recombination-activating protein 2 RAG2 Canis lupus familiaris (Dog) (Canis familiaris) B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; DN2 thymocyte differentiation [GO:1904155]; organ growth [GO:0035265]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]" CFSAEANSFDGDDAFDTYNE;DDEEDESETGYWITCCPTCD;DESETGYWITCCPTCDVDVNTW;EANSFDGDDAFDTYNEDDEEDES;ESETGYWITCCPTC;ESETGYWITCCPTCDV;FDTYNEDDEEDESET;TYNEDDEEDESETGYW 8 8.7 0.56566 0.4027 4.89719 6.76394 6.85375 6.85087 0 0 8.734 0 0 0 0 0 2.1921 7.48696 0 A0A8I3P8Z6 A0A8I3P8Z6_CANLF Neurogenin 2 NEUROG2 Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; forebrain development [GO:0030900]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" HCGGGGGG;TVQRIKKTRRLK 2 7.4 0.9461 0.05044 0 0 4.30612 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P907 A0A8I3P907_CANLF Selenophosphate synthetase 1 SEPHS1 Canis lupus familiaris (Dog) (Canis familiaris) selenocysteine biosynthetic process [GO:0016260] cytoplasm [GO:0005737] "ATP binding [GO:0005524]; selenide, water dikinase activity [GO:0004756]" GFKDAAEEAGTS;VLGGVATT 2 6.2 0.98953 -0.21548 0 0 0 0 0 0 0 0 11.3838 0 0 0 0 0 0 A0A8I3P908 A0A8I3P908_CANLF RNA helicase (EC 3.6.4.13) DDX49 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell growth [GO:0030307]; regulation of rRNA stability [GO:0044357] nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] HMVMCLAWDSSP;SPGPTQSLSVGPKTPMLCTAQLFH 2 5.6 0.99529 -0.19043 0 0 0 0 0 0 0 0 15.405 0 0 0 0 0 10.2277 A0A8I3P913 A0A8I3P913_CANLF Protein sprouty homolog 1 SPRY1 Canis lupus familiaris (Dog) (Canis familiaris) animal organ development [GO:0048513]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of Ras protein signal transduction [GO:0046580] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleoplasm [GO:0005654] APRTLPSCL;SNDDEGDSYSDNPCSCSQSHCCSR 2 10.3 0.98887 -0.21797 9.03378 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P923 A0A8I3P923_CANLF Hydroxysteroid 17-beta dehydrogenase 2 HSD17B2 Canis lupus familiaris (Dog) (Canis familiaris) androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; in utero embryonic development [GO:0001701]; placenta development [GO:0001890]; response to retinoic acid [GO:0032526] endoplasmic reticulum membrane [GO:0005789] estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035] EVTKAFLPLLRKSKGRLV;VHITGLPPDSLCPLASP 2 7.9 0.99172 0.00029822 0 0 0 3.99041 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P924 A0A8I3P924_CANLF "NADPH:adrenodoxin oxidoreductase, mitochondrial (EC 1.18.1.6)" FDXR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; ubiquinone biosynthetic process [GO:0006744] mitochondrion [GO:0005739] NADPH-adrenodoxin reductase activity [GO:0015039] DSEDLPCGLVLSSVGYKSRPIDP;GKGAGKPR;GVFSARAFVGWY;GVIATTMTDSF 4 12 1.0032 -1.9145 8.58331 0 0 0 0 0 10.3766 0 0 0 9.26641 0 0 0 0 A0A8I3P925 A0A8I3P925_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) MYYCACWKGSTASE 1 7.3 0.93636 0.060913 0 0 0 0 0 0 0 0 0 0 0 10.7753 0 0 0 A0A8I3P946 A0A8I3P946_CANLF "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase (POMGnT1) (EC 2.4.1.-)" POMGNT1 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane organization [GO:0071711]; dentate gyrus development [GO:0021542]; gene expression [GO:0010467]; localization of cell [GO:0051674]; myelination [GO:0042552]; O-glycan processing [GO:0016266]; protein O-linked mannosylation [GO:0035269]; reactive gliosis [GO:0150103]; sensory perception of sound [GO:0007605] Golgi membrane [GO:0000139] "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [GO:0047223]; carbohydrate binding [GO:0030246]; manganese ion binding [GO:0030145]" EGHTYVAF;FLEPPPKEEGVPGAAEQ;GSGPRRVL;KLWDWDMWMRMPE;LRGIQHTPISI 5 8.6 0.99341 -0.55696 0 0 7.66413 0 0 0 2.17479 0 10.1995 0 0 0 8.73434 0 10.8499 A0A8I3P948 A0A8I3P948_CANLF Chloride channel accessory 4 CLCA4 Canis lupus familiaris (Dog) (Canis familiaris) intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] DNGYEGIIF;ENHNREAPSI;GALASGNTDLSQQPLQL;GVWTYSLQ;PSADQAVIEMSTI;TANGGTSI 6 7.2 1.0008 -2.7553 0 0 0 0 0 13.1856 0 0 10.0325 8.21946 0 10.3372 0 10.0916 0 A0A8I3P955 A0A8I3P955_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] GILHSSGSSYSYPQ 1 11.1 0.94301 0.061103 0 0 0 0 0 0 8.5474 0 0 0 0 0 0 0 0 A0A8I3P957 A0A8I3P957_CANLF Filamin A interacting protein 1 like FILIP1L Canis lupus familiaris (Dog) (Canis familiaris) DKVMEKHKESH;DTEGSAQKQFP;IQDLTTSAKETH;KHKEYMEKSDEFISLLEQECERLKR;LKQTEDKLQAASSQLQ;LVDERKTMSE;NERDKAQFL;NLEKERMTT;VLEALQRDAFQAKS 9 10.3 1.0029 -1.7421 0 0 0 0 11.5468 0 0 0 0 0 4.18063 9.79941 0 0 11.5661 A0A8I3P959 A0A8I3P959_CANLF Homeobox protein Hox-D4 HOXD4 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; stem cell differentiation [GO:0048863] cell junction [GO:0030054]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" MKKVHVNSVN;NTKGRSSSS;YTRQQVLELEKEFHF 3 13.2 0.98907 -0.52499 0 0 0 0 0 0 10.3028 0 0 0 0 0 0 11.4392 0 A0A8I3P965 A0A8I3P965_CANLF Ras association domain family member 1 RASSF1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FIKVQLKLVRPV;NSQINSNLFMSLNKD;PLRLRLLAGPS;WDAFSMPELHNFLRILQREEE 4 21.7 0.8709 0.18757 0 0 8.73203 0 3.08536 0 0 0 4.23726 0 0 0 0 0 0 A0A8I3P970 A0A8I3P970_CANLF Leucine rich repeat containing 17 LRRC17 Canis lupus familiaris (Dog) (Canis familiaris) bone marrow development [GO:0048539]; negative regulation of osteoclast differentiation [GO:0045671] extracellular space [GO:0005615] DQDTEDDE;NQLRPKEFEDVHE;RCDYNIHYLYY 3 7.5 1.0025 -1.3422 4.38667 0 0 0 0 5.72653 0 0 0 0 0 0 0 0 0 A0A8I3P973 A0A8I3P973_CANLF Polynucleotide kinase 3'-phosphatase PNKP Canis lupus familiaris (Dog) (Canis familiaris) DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via nonhomologous end joining [GO:0006303]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; polynucleotide 3'-phosphatase activity [GO:0046403] ASHCWRREEGE;STFLQEHLVSAGYVH 2 4.4 0.99197 -0.18109 0 8.19121 0 0 0 0 0 0 0 0 0 12.7996 0 0 0 A0A8I3P974 A0A8I3P974_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) UBR1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to L-leucine [GO:0071233]; negative regulation of TOR signaling [GO:0032007]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] proteasome complex [GO:0000502]; ubiquitin ligase complex [GO:0000151] L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ALMQFAIAQKIT;DQQVDFYTTFLHHLAQLV;EEIARSQETNQM;GGGFCDCGDT;GHTLETKSYKVS;GVPGWYLWVS;GVTPPEELLTNP;IMSYSSDFRQI;RCAALFFHYLL;RCPRSADDERKHP;SFFMEMEYKKFFAMEFVKYYKQ;SIQMSIFTPLEWYLF;SVQMFTVP;VITETLLEVLPE 14 10.2 1.0012 -2.6994 8.92641 6.29135 0 0 8.89005 0 10.2254 12.4276 0 0 8.94997 9.54481 9.25583 0 8.99121 A0A8I3P977 A0A8I3P977_CANLF t-SNARE coiled-coil homology domain-containing protein STX3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] AALPLLPFPP;ARKKLIIIIVVVVVL;ARKKLIIIIVVVVVLL;GQARKKLIIIIVVVVVLLGILAL;IIIIVVVVVLLGILALIIGL;IIIVVVVVLLGILALIIGLS;IKELHDMFVDI;KKLIIIIVVVVVLLGIL;KKLIIIIVVVVVLLGILAL;KKLIIIIVVVVVLLGILALII;KLIIIIVVVVVLLGIL;KLIIIIVVVVVLLGILAL;KLIIIIVVVVVLLGILALI;KLIIIIVVVVVLLGILALII;KLIIIIVVVVVLLGILALIIGL;KLIIIIVVVVVLLGILALIIGLS;LIIIIVVVVVLLGILALII;LIIIIVVVVVLLGILALIIG;LIIIIVVVVVLLGILALIIGL;QARKKLIIIIVVVVVLL;QARKKLIIIIVVVVVLLGIL;RKKLIIIIVVVVVLL;RKKLIIIIVVVVVLLGI;RKKLIIIIVVVVVLLGILAL 24 10.1 0.99527 -0.08269 8.45828 12.0652 7.45869 5.73281 11.9078 4.51583 8.14343 9.15709 8.85269 0 5.71276 5.86277 9.69105 7.28808 9.82784 A0A8I3P986 A0A8I3P986_CANLF MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) MKNK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] GVVLYIMLSGYPPFVGHC;QRNSSTMDLTLF 2 9 0.93986 0.10318 5.17301 0 0 0 0 0 0 6.43401 0 0 0 0 0 0 0 A0A8I3P988 A0A8I3P988_CANLF Proprotein convertase subtilisin/kexin type 2 PCSK2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] ERFHCVGGSVQ;GSYDDCNCDGY;YDDCNCDGYAS 3 4 0.98712 -0.23096 0 0 10.1546 0 0 0 0 0 0 0 0 5.88193 0 0 0 A0A8I3P989 A0A8I3P989_CANLF V-type proton ATPase subunit a ATP6V0A2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879] "acrosomal vesicle [GO:0001669]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" FPASETNGLYSGQEHVQR;NENHPRLNQ;SFRLLSSK 3 4.1 0.98733 -0.33799 9.16045 10.127 0 0 0 0 10.2256 0 0 13.4108 10.8424 0 10.7512 10.6587 0 A0A8I3P997 A0A8I3P997_CANLF Glutamate receptor GRID2 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] GLVGELVF;HLHRRVNSLCTDDDSP;PHKQFSTSSIDLTPLDIDT;QDLSKQTDIPYG;SLTDKKLENNMRGVVL 5 8.1 0.9879 -0.37294 0 10.9625 11.0733 6.99594 0 0 11.5373 0 0 10.9656 0 0 11.704 5.2135 11.9443 A0A8I3P9A3 A0A8I3P9A3_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN5 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] GGCCEFTC 1 4.8 0.98951 -0.26592 0 0 0 0 0 0 0 0 9.00492 0 0 0 0 0 0 A0A8I3P9C3 A0A8I3P9C3_CANLF Heat shock transcription factor 2 binding protein HSF2BP Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair involved in meiotic recombination [GO:1990918]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; spermatogenesis [GO:0007283] chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] ESPGFIPLL;RRRAPPLAARPGGEGGP 2 5.8 0.98924 -0.26319 8.75425 8.5998 0 0 0 0 0 0 9.01912 0 3.58232 0 0 0 0 A0A8I3P9C7 A0A8I3P9C7_CANLF Sorbin and SH3 domain containing 2 SORBS2 Canis lupus familiaris (Dog) (Canis familiaris) CSESDFDHFSFTSSESFY;DFDHFSFTSSESFYGSSHHHHHHHH;DSTEAYPQHAQSLDGT;DTNVELSLRKGDRV;EKLIPPEKAQPARP;FTHENIQGG;HHHHRHLISSC;NIQGGGEPN;RFTTMLKHERAKHENSEE;STEEVPRD 10 11 0.99726 -3.4528 0 0 0 0 7.90791 8.21796 0 0 13.6259 0 0 0 7.62198 9.76308 0 A0A8I3P9C9 A0A8I3P9C9_CANLF Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA--protein transferase activity [GO:0004057] GAERRGRPRRTP;GGGGGGGE;GGGGGGGG;HCGGGGGG;HCGGGGGGG;TFQESYQVYKRYQM 6 4.6 1.0033 -1.6113 7.11977 0 0 0 7.16239 2.87706 10.1092 9.58248 6.5846 0 0 3.56608 0 0 7.06372 A0A8I3P9D1 A0A8I3P9D1_CANLF Uncharacterized protein REX1BD Canis lupus familiaris (Dog) (Canis familiaris) LGFSCPDPSCPSP;LGFSCPDPSCPSPG 2 4.5 0.98872 0.034453 0 9.33642 0 0 9.61642 9.62449 11.7328 0 0 0 11.7693 0 11.7031 11.6257 11.6829 A0A8I3P9D4 A0A8I3P9D4_CANLF SLIT and NTRK like family member 4 SLITRK4 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] IVSYQTRVP;LPYIGVLEHIGR;LWLEKLNDGIV;TNPSKISGIV;VLDQLQSLTQID 5 6.4 0.98798 -0.48907 4.89327 0 0 0 0 9.90417 0 0 0 0 0 0 10.3866 0 0 A0A8I3P9E1 A0A8I3P9E1_CANLF Tubulin alpha chain TUBA1C Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] AVFVDLEPTVIDEV;DEITHRKEHHNREDPSLRECIS;DIERPTYTNL;DVVPKDVNAAIA;EKAYHEQLTVAEI;GDVVPKDVNAAIA;THTTLEHSDC;TVVPGGDLAKVQ;VFVDLEPTVIDEV 9 19.5 0.98446 -0.25727 0 0 10.2689 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9F6 A0A8I3P9F6_CANLF DExH-box helicase 57 DHX57 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] AEVEKESEPEEETDEDE;EDDEPDCDDE;EQYWSAGREASLVPDCEP;GEEEDDEPDC;GEEEDDEPDCDD;GEEEDDEPDCDDEQ;GKPGKGGG;GVLLRRLE;HSSLSSEEQQAVFVKPPVGV;ICRKPVIPNNSFTSSQ;LARYKGVS;LMSATLNAELFSE;PEEETDEDEG;PGKGGGKG;SGEEEDDEPDCDDEQ;YLALLRAYKGWQLSMKEGMRASYN 16 11.1 0.99704 -4.049 16.8874 16.7549 16.6711 15.1889 15.3046 15.2586 16.5861 16.5129 16.5624 16.3229 16.4834 16.3325 17.1131 17.1078 17.1638 A0A8I3P9G1 A0A8I3P9G1_CANLF Pellino E3 ubiquitin protein ligase 1 PELI1 Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked ubiquitination [GO:0070936]; regulation of Toll signaling pathway [GO:0008592] ubiquitin protein ligase activity [GO:0061630] AEGLSHTPTVKH;VHIACTPQAAKIGR 2 6.8 0.91744 0.11193 0 11.8985 11.9176 0 0 0 12.6457 0 0 10.103 9.38797 9.83086 0 0 0 A0A8I3P9G4 A0A8I3P9G4_CANLF DNA topoisomerase (EC 5.6.2.1) TOP3A Canis lupus familiaris (Dog) (Canis familiaris) DNA topological change [GO:0006265] chromosome [GO:0005694] "DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; zinc ion binding [GO:0008270]" EVRSKSKSKWRPQAL;GHLGMGLV;HAEHIETI;KKPRKCSLCHQPG;MGLVEGYDSM;VELEKLASRKLRI 6 6.9 1.0026 -0.98159 9.95948 0 9.86722 0 0 0 0 0 0 0 0 0 0 0 10.4858 A0A8I3P9H0 A0A8I3P9H0_CANLF Olfactory receptor OR52AB2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GLLPILIKRLHV;IVIVAIRATVLVGLLPILI;LISYILIFQAVFHLR;LLPILIKRLHVFH;LLPILIKRLHVFHSIVIAH;LSTIYLLVPPALN;LVGLLPILIKRLHVFH;RMIVIVAIRATVLVGLLPILIKR;VGLLPILIKRL 9 19.6 0.88564 0.13203 8.13627 4.53587 0 3.14387 0 7.74833 5.07549 0 0 0 5.11811 3.72104 5.30823 0 9.43141 A0A8I3P9H1 A0A8I3P9H1_CANLF Dystrophin DMD Canis lupus familiaris (Dog) (Canis familiaris) muscle cell development [GO:0055001]; neuron development [GO:0048666]; regulation of muscle system process [GO:0090257]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536] postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383] zinc ion binding [GO:0008270] FLSTSVQGPWE;KDLRQWQINVDVANDL;KVHMITENINASW;LEDSKGVREL;LVESMMNSHLQGA;VAIEDRIRQLHEAH 6 6.1 0.98523 -0.25864 0 0 0 8.87995 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9H2 A0A8I3P9H2_CANLF Chromobox 5 CBX5 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122] "chromocenter [GO:0010369]; chromosome, telomeric region [GO:0000781]; histone deacetylase complex [GO:0000118]; histone methyltransferase complex [GO:0035097]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]; ribonucleoprotein complex [GO:1990904]; site of DNA damage [GO:0090734]; transcription repressor complex [GO:0017053]" chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; ribonucleoprotein complex binding [GO:0043021] PQIVIAFYEERLTWHAYPEDAE;SSSEDEEEYVVE 2 17.8 0.989 -0.21797 0 0 0 0 0 0 0 0 0 0 0 0 9.1752 9.70765 0 A0A8I3P9I7 A0A8I3P9I7_CANLF "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3)" ST6GALNAC2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] GEQRSQLPTPVPTR 1 2.4 0.99323 -0.1499 0 0 0 0 0 0 0 0 0 0 0 0 10.3461 10.5064 0 A0A8I3P9K0 A0A8I3P9K0_CANLF ADP-ribosylation factor 4 ARF4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GAEELQKMLQEDELRDAVLLLFA 1 15 0.97618 0.04644 0 0 0 0 0 7.25729 0 0 0 0 0 0 0 0 0 A0A8I3P9K5 A0A8I3P9K5_CANLF N-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase) NAGK Canis lupus familiaris (Dog) (Canis familiaris) N-acetylglucosamine kinase activity [GO:0045127] AALYGGVEGGGSRS;INPDGSESGCGGWGHMMG;QDGGIVLISGTGSNCRLI;SGCGGWGHMMGDE 4 14.8 0.97379 0.036725 0 5.82957 19.4935 4.5645 0 0 7.02425 19.9321 0 0 0 19.8964 4.62696 0 0 A0A8I3P9L3 A0A8I3P9L3_CANLF Discs large MAGUK scaffold protein 4 DLG4 Canis lupus familiaris (Dog) (Canis familiaris) AMPA glutamate receptor clustering [GO:0097113]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970] basolateral plasma membrane [GO:0016323]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] kinase binding [GO:0019900] HIGDDPSIFITKIIPGGA;IGFIPSKRRV;IVEGDSFEEIYHKVKRV;VTHSAAVEALKEAGS 4 8.6 0.97405 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 6.43937 0 A0A8I3P9L4 A0A8I3P9L4_CANLF Tetraspanin TSPAN1 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] ALVYTTMAEHFL;GALELAAMIVSMYLYC;GIWVSVDGP;VAAAVVALVYTT 4 17.8 1.0024 -0.99087 10.1334 0 0 8.99263 0 0 12.3548 0 0 0 0 0 0 0 0 A0A8I3P9M0 A0A8I3P9M0_CANLF Phosphopantothenoylcysteine synthetase PPCS Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA biosynthetic process [GO:0006085]; coenzyme A biosynthetic process [GO:0015937]; heart process [GO:0003015] phosphopantothenate--cysteine ligase activity [GO:0004632]; protein homodimerization activity [GO:0042803] AAAGTFLAVEFTT;IVDDLQSRHTVF;NALEVYRHQVVVANSLESH;RARNALEVYRHQVVVANSLESHG;VPLEARPVRFL;YLAAAVSDFYVP 6 22.8 1.0011 -0.64523 9.48764 0 0 0 0 10.6964 0 0 0 0 0 0 0 0 0 A0A8I3P9M4 A0A8I3P9M4_CANLF Collagen type XX alpha 1 chain COL20A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] ALGSPARVFL;ASFQLQMLQIVCNDSWADEDVCCE;CPDPEPLG;EAWVHGCMGEDVSF;EGARAYREAWVH;EVMLTTKTPKATVGGLSP;IVCNDSWADEDVCC;IVCNDSWADEDVCCE;VGKAGVGEGLRGLVTTAPLPP;VGSSPSLL 10 9.3 1.0039 -1.0739 0 8.19249 0 0 0 0 0 11.4919 0 0 9.8289 0 0 0 0 A0A8I3P9M5 A0A8I3P9M5_CANLF PHD finger protein 1 PHF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] APGAKGAG;TDGLLYLGTIKK;TPKGERSSKLLSALNSHKDR 3 8.8 0.98961 -0.26592 0 0 0 0 0 0 12.2029 0 0 0 0 0 0 0 0 A0A8I3P9M7 A0A8I3P9M7_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) MINDY1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] nuclear body [GO:0016604] cysteine-type carboxypeptidase activity [GO:0016807]; cysteine-type deubiquitinase activity [GO:0004843]; histone deubiquitinase activity [GO:0140934]; K48-linked deubiquitinase activity [GO:1990380]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435] NHFSTMTKHKSHLYLLVTDQGFL;NVDGDSCFCDSD;VTDQGFLQEEQ 3 8.4 0.98898 -0.52436 0 0 8.91749 0 0 0 0 11.8406 6.90749 0 0 9.09273 8.99164 8.75792 0 A0A8I3P9M8 A0A8I3P9M8_CANLF Cytochrome P450 family 4 subfamily V member 2 CYP4V2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid omega-oxidation [GO:0010430] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FAIMEEKTVLSCVLRHFW;IAERSSELKRDE;LGSYPEVQKQVDS;YPEVQKQVDSE 4 8.4 0.98788 -0.49624 9.33715 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9N3 A0A8I3P9N3_CANLF carbamoyl-phosphate synthase (ammonia) (EC 6.3.4.16) CPS1 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; glutamine metabolic process [GO:0006541] ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; metal ion binding [GO:0046872] LAAGAKTY;LDRFHGTSSRIGS;SAVLDELKVAQAPWKAVN;VGEVMAIGRTFEESLQ;VHSGDATL;VVRDADDNCVTVCNMENVDA 6 5.5 1.0022 -1.3914 0 0 0 0 0 0 0 9.9275 0 8.86814 11.6105 8.9116 0 0 0 A0A8I3P9N4 A0A8I3P9N4_CANLF Protein tyrosine phosphatase non-receptor type 9 PTPN9 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron projection development [GO:0010977]; positive regulation of protein localization to plasma membrane [GO:1903078] cytoplasm [GO:0005737]; neuron projection terminus [GO:0044306] protein tyrosine phosphatase activity [GO:0004725] KCGQYWPLERD;VLNLLKGAFPARLKKVLIVGAPI;WRPPGLSA 3 5.5 1.0024 -1.0226 0 3.58785 0 0 0 0 0 0 7.88826 0 0 0 0 14.2028 7.88332 A0A8I3P9N9 A0A8I3P9N9_CANLF 1-acylglycerol-3-phosphate O-acyltransferase 5 AGPAT5 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] KLQSYMNAGTPMYLVIFP;LLSAFLPARLYQAVDDRLY;LVLHMYSMRCVLPAAVLLGSAPTY;RNKFPGESVNSKLSLKKTLPSL 4 17.5 0.86939 0.18717 0 9.19582 0 2.85196 7.79045 0 9.0724 0 0 0 0 0 0 0 0 A0A8I3P9P0 A0A8I3P9P0_CANLF Uncharacterized protein LOC485485 Canis lupus familiaris (Dog) (Canis familiaris) LWEEAQALREENMALREE;NRGLKAQI 2 10.2 0.98937 -0.21489 0 13.1171 10.1551 0 0 11.0966 0 0 0 0 0 0 0 0 0 A0A8I3P9P1 A0A8I3P9P1_CANLF Vasoactive intestinal peptide receptor 1 VIPR1 Canis lupus familiaris (Dog) (Canis familiaris) "cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]" plasma membrane [GO:0005886]; receptor complex [GO:0043235] peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999] GGGGGGGA;LVNFILFIRIIRILVQK;WQGGFLEEVALE 3 6.5 0.98977 -0.21148 0 0 0 0 0 0 0 0 0 0 0 10.6743 0 0 5.42139 A0A8I3P9P2 A0A8I3P9P2_CANLF Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) HOOK3 Canis lupus familiaris (Dog) (Canis familiaris) CAAX-protein geranylgeranyltransferase complex [GO:0005953]; protein farnesyltransferase complex [GO:0005965] CAAX-protein geranylgeranyltransferase activity [GO:0004662]; protein farnesyltransferase activity [GO:0004660] AIELNAANYTVW;LVDIYEDMLENQ;TYVLYRDRAEWADIDP;VLYRDRAEWADIDPV 4 10.8 0.98807 -0.47141 0 0 0 12.5635 0 0 0 8.2891 4.80178 0 0 0 0 0 0 A0A8I3P9P5 A0A8I3P9P5_CANLF Zinc finger and BTB domain containing 42 ZBTB42 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] VPGHGARLL 1 2.3 1.0046 -0.80421 9.15879 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9P6 A0A8I3P9P6_CANLF Protein arginine methyltransferase NDUFAF7 (EC 2.1.1.320) NDUFAF7 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] mitochondrion [GO:0005739] methyltransferase activity [GO:0008168] LTADVDFSYLRRMAEGQVAS 1 5.8 0.98376 -0.24292 0 8.83245 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9P7 A0A8I3P9P7_CANLF Myristoylated alanine-rich C-kinase substrate MARCKS Canis lupus familiaris (Dog) (Canis familiaris) actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; apoptotic process [GO:0006915]; mitochondrion organization [GO:0007005]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; response to endoplasmic reticulum stress [GO:0034976] actin filament bundle [GO:0032432]; cell cortex [GO:0005938]; centrosome [GO:0005813]; germinal vesicle [GO:0042585]; membrane [GO:0016020] actin filament binding [GO:0051015]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; protein kinase C binding [GO:0005080] AAEQAAAGGPQEAQPR;AEAAGEAAEAAEPR;AEPGEAAGEAAGEA;EDGAAPSPSGETPK;GEAAEAAEPRAAE;PGEAAGEAAGEAAE;RFSFKKSFKLSGFS 7 20.8 0.85935 0.16287 7.6074 0 10.5384 0 8.53555 7.44079 10.4743 8.61353 8.66494 7.97183 9.09814 9.10192 7.05452 8.51239 0 A0A8I3P9Q5 A0A8I3P9Q5_CANLF High mobility group protein B2 (High mobility group protein 2) HMGB2 Canis lupus familiaris (Dog) (Canis familiaris) cell chemotaxis [GO:0060326]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; DNA metabolic process [GO:0006259]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; response to steroid hormone [GO:0048545]; spermatid nucleus differentiation [GO:0007289] chromatin [GO:0000785]; condensed chromosome [GO:0000793]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] "chemoattractant activity [GO:0042056]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor binding [GO:0140297]; protein domain specific binding [GO:0019904]; RAGE receptor binding [GO:0050786]; transcription coactivator activity [GO:0003713]" EEEEEDEDDEEEE;HPDSSVNFAEFSKKCSERWKT;PDSSVNFAEFSKKCSERWK 3 16.2 0.98775 -0.23432 0 0 7.03199 0 0 0 0 0 0 0 0 7.90983 0 0 0 A0A8I3P9R1 A0A8I3P9R1_CANLF "Sprouty-related, EVH1 domain-containing protein 2" SPRED2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658] EDYRHAPVRG;RQVSFPDDDEEIVRINP 2 6.5 0.99645 -0.57537 0 0 10.8801 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9S1 A0A8I3P9S1_CANLF Mitochondrial ribosomal protein L57 MRPL57 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrial large ribosomal subunit [GO:0005762] structural constituent of ribosome [GO:0003735] PPHRFVADQLDH;QWIGKHRRP;TALLLRNRI 3 29.4 1.0015 -0.91754 0 10.0991 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3P9T2 A0A8I3P9T2_CANLF Phospholipid scramblase PLSCR4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lipopolysaccharide [GO:0071222] plasma membrane [GO:0005886] CD4 receptor binding [GO:0042609]; enzyme binding [GO:0019899]; phospholipid scramblase activity [GO:0017128] CCCFCCPS;CSCCCFCCPSTRQ;RCSCCCFCCPS;SCCCFCCPS 4 4.2 1.0031 -2.151 4.10986 0 0 0 0 0 4.78073 0 0 0 9.10654 0 0 0 0 A0A8I3P9T6 A0A8I3P9T6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] NSKYIQLYVLHTE 1 5.9 0.94198 0.059729 0 0 0 0 0 0 7.73268 0 0 0 0 0 0 0 0 A0A8I3P9T9 A0A8I3P9T9_CANLF Protocadherin 1 PCDH1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] cell junction [GO:0030054]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ESETPSSKSSSGPR;GVASYELQAGP;KPPRYGTALVHLYVNE;STFVPYQDRGGQ 4 4.3 0.9876 -0.40224 0 0 0 0 0 0 0 0 0 0 0 0 9.51519 0 9.44684 A0A8I3P9W0 A0A8I3P9W0_CANLF Olfactory receptor OR4D9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ESHLHTPMYFL;GADVFSLSVMAF;PKVLVDLLSKRKTI;SLVLASWVG;VILMMLRSHA 5 17.9 1.0028 -1.5373 0 0 0 0 0 11.2394 0 0 8.59679 0 0 0 0 0 0 A0A8I3P9W4 A0A8I3P9W4_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (EC 3.1.4.11)" PLCG2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; phospholipid catabolic process [GO:0009395] phosphatidylinositol phospholipase C activity [GO:0004435] VEDISTVDVEELEKQI 1 1.3 0.95575 0.049233 0 0 0 0 0 8.5022 0 0 0 0 0 0 0 0 0 A0A8I3P9W8 A0A8I3P9W8_CANLF Protein phosphatase 1 regulatory subunit 14 PPP1R14C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] protein serine/threonine phosphatase inhibitor activity [GO:0004865] LEEWIVEQLGQLYGCEEEE;VDCYKPTEEFIQ 2 18.7 0.99078 -0.13568 12.2483 0 0 0 0 0 0 0 0 0 0 0 0 0 9.46377 A0A8I3P9W9 A0A8I3P9W9_CANLF 2'-5' oligoadenylate synthase (EC 2.7.7.84) OAS1 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; defense response to bacterium [GO:0042742]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; interleukin-27-mediated signaling pathway [GO:0070106]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of IP-10 production [GO:0071659]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of tumor necrosis factor production [GO:0032760]; surfactant homeostasis [GO:0043129]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142] cytosol [GO:0005829]; nucleoplasm [GO:0005654] 2'-5'-oligoadenylate synthetase activity [GO:0001730]; double-stranded RNA binding [GO:0003725] HRTYSYHDYGWRPV;REETFEVYFEV;VGSWDVLLEEDYEDN 3 10 0.84964 0.15013 9.56379 7.36492 0 0 0 0 0 9.05572 0 0 0 0 0 0 0 A0A8I3P9X0 A0A8I3P9X0_CANLF Coiled-coil domain containing 154 CCDC154 Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization involved in bone maturation [GO:0035630]; bone resorption [GO:0045453]; odontogenesis of dentin-containing tooth [GO:0042475]; tooth eruption [GO:0044691] ELAAYVQESLAAMQLAGE;FEAMRQEL;NPGRKIAEIQG 3 7.1 0.98626 -0.42136 0 0 0 0 0 10.1919 0 0 0 0 0 0 0 0 11.3961 A0A8I3P9X7 A0A8I3P9X7_CANLF POU domain protein POU6F2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] HSPFQRQH;KAFKIRRLSL;PPPQPQNHNHNHSRASPPQ 3 5.3 0.95055 0.049546 0 0 0 0 0 0 0 0 0 8.04947 0 0 0 0 0 A0A8I3P9X9 A0A8I3P9X9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RTEPSLHK 1 2.5 0.989 -0.26285 0 0 0 0 0 0 0 0 0 0 9.84591 0 0 0 0 A0A8I3P9Z5 A0A8I3P9Z5_CANLF EPS8 like 2 EPS8L2 Canis lupus familiaris (Dog) (Canis familiaris) EKIRQRQSVLP;EQSKPDIHFFYCDEVEAD;NQRKKGKKKGKKG;PWCLCQEHLATF;SELEELMSKFHS;VGFLRGHL 6 10.4 1.0034 -2.0874 5.54074 0 11.0818 10.786 0 0 13.8543 0 12.6369 4.32301 0 0 0 0 0 A0A8I3PA02 A0A8I3PA02_CANLF Charged multivesicular body protein 5 (Chromatin-modifying protein 5) CHMP5 Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; vesicle budding from membrane [GO:0006900] multivesicular body [GO:0005771] WELSSAPCHPARLPP 1 3.1 0.99469 -0.154 0 0 0 0 0 0 8.95341 0 0 0 0 0 0 0 0 A0A8I3PA03 A0A8I3PA03_CANLF LIM domain and actin binding 1 LIMA1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of actin filament depolymerization [GO:0030835]; ruffle organization [GO:0031529] brush border membrane [GO:0031526]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle [GO:0001726]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; actin monomer binding [GO:0003785] NTENLPQHC 1 1.2 0.9852 -0.25937 0 0 0 9.83602 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PA06 A0A8I3PA06_CANLF Bone morphogenetic protein 3 BMP3 Canis lupus familiaris (Dog) (Canis familiaris) osteoblast differentiation [GO:0001649] extracellular space [GO:0005615] BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083] IEPRNCARRYLKVDFADIGW;KTLQTQAPEKTKNKKKQRK;QLPKKRLPFPEPYI 3 11.2 0.85833 0.16039 0 0 0 0 0 0 0 0 0 0 0 0 10.664 3.49365 0 A0A8I3PA15 A0A8I3PA15_CANLF Transportin 3 TNPO3 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; nuclear envelope [GO:0005635] identical protein binding [GO:0042802]; small GTPase binding [GO:0031267] DVTSLPFLLEIL;HFNGLLEIARSLDSF;SVDPKKPFSNDLSHCSL;TAVRYTSIELVGE;VIPILQWAI 5 6.9 1.0027 -0.72266 0 9.66345 7.45401 0 9.17228 0 8.90421 0 0 0 0 0 0 0 0 A0A8I3PA19 A0A8I3PA19_CANLF "Necdin, MAGE family member" NDN Canis lupus familiaris (Dog) (Canis familiaris) axon extension [GO:0048675]; axonal fasciculation [GO:0007413]; central nervous system development [GO:0007417]; genomic imprinting [GO:0071514]; glial cell migration [GO:0008347]; multicellular organismal-level homeostasis [GO:0048871]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; respiratory system process [GO:0003016]; sensory perception of pain [GO:0019233] cell projection [GO:0042995]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] gamma-tubulin binding [GO:0043015]; promoter-specific chromatin binding [GO:1990841] ILRRTSLILARVFGLHLR 1 5.5 0.98093 0.048313 0 0 6.54976 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PA23 A0A8I3PA23_CANLF NK6 homeobox 1 NKX6-1 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system neuron differentiation [GO:0021953]; negative regulation of oligodendrocyte differentiation [GO:0048715]; oligodendrocyte differentiation [GO:0048709]; pancreatic A cell differentiation [GO:0003310]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of axon extension [GO:0030516]; regulation of neuron migration [GO:2001222]; smoothened signaling pathway [GO:0007224]; type B pancreatic cell differentiation [GO:0003309] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAVGRYPKP;TESQVKVWFQ 2 5.2 1.0043 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.2601 A0A8I3PA25 A0A8I3PA25_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2" SMARCD2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SWI/SNF complex [GO:0016514] transcription coregulator activity [GO:0003712] DIDVEVDDPLKAQMSNFLASTTNQQ;GDTAGTAGP;RRGLKRRKMADKVL 3 10.5 1.0029 -1.0241 17.0771 11.4374 6.98993 0 0 0 11.6746 0 11.8421 0 0 0 0 0 0 A0A8I3PA27 A0A8I3PA27_CANLF Olfactory receptor OR4D11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VASWVGGFVHSIVQISLL;VLKLACTDTFAL 2 9.6 0.99366 -0.075929 0 0 3.52857 11.8235 0 0 0 0 0 0 0 0 10.4356 0 0 A0A8I3PA28 A0A8I3PA28_CANLF Zinc finger protein 473 ZNF473 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CRSHELKT;GAKTCPLAEDYLEGL;LDQNQQEGIQEGE;SFRQSSCLS;TLEDWEHLG;VETPYECQECGE;YVCQECGKAFTQSSCLSV 7 9.6 1.0012 -2.7134 9.39633 10.4071 0 0 0 0 9.8627 0 0 9.23477 0 0 0 0 8.45722 A0A8I3PA32 A0A8I3PA32_CANLF PHD finger protein 2 PHF2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of rDNA heterochromatin formation [GO:0061188]; transcription initiation-coupled chromatin remodeling [GO:0045815] kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] histone H3K9 demethylase activity [GO:0032454]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] DDYEEEQDHLDAC;DSGGASAWYH 2 2.1 0.99167 -0.20833 0 0 0 0 0 0 8.39515 0 0 0 0 0 0 6.76527 0 A0A8I3PA36 A0A8I3PA36_CANLF DR1 associated protein 1 DRAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] negative cofactor 2 complex [GO:0017054]; RNA polymerase II transcription regulator complex [GO:0090575] core promoter sequence-specific DNA binding [GO:0001046]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TBP-class protein binding [GO:0017025] AEDEEDYD;LVSPQHPFRGWRRQGPS;PGRTSLVSPQHPFRGWRRQG 3 10.4 1.0028 -1.3512 0 10.3244 0 11.8621 0 7.45047 11.7885 12.0301 0 0 0 0 0 10.47 0 A0A8I3PA37 A0A8I3PA37_CANLF Phospholipid scramblase LOC100688853 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid scramblase activity [GO:0017128] LTQINQLLVCQRFDLL 1 6.8 0.96289 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 9.52564 0 A0A8I3PA39 A0A8I3PA39_CANLF Uncharacterized protein LOC492181 Canis lupus familiaris (Dog) (Canis familiaris) CWYEGALRDEEVRA;FYVLVNSLELTHEEMLSNNQSMPK;GVSDSSGE;PITKVEVLKVVIKRYKKQFPVIF;VLKVVIKRYK 5 21.5 1.0048 -1.0506 0 0 8.74967 8.7097 8.43813 9.43018 0 0 0 6.5821 9.04772 9.10839 0 9.08484 9.33575 A0A8I3PA47 A0A8I3PA47_CANLF Multiple EGF like domains 6 MEGF6 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CECQHGAS;CQYDVNECASGNGGCEDQCYNTV;CSGSCYCGGAPCN;DCADSPCCQQVCTNSP;DCSHPCTCSPGHGSCDA;DGCGCEDVDECASGRGGCEHHC;EPGTGACLCRPGYVGSRCQ;FYGKQCHKKCHC;GDDCGADC;GPGCAHVC;GPGWMGSTCLE;GVCDCAAG;GVNCEHVCSCR;HYGAACRLE;MRCSCANDGLCHPVTGR;PDCSHPCTCSPG;PDCSHPCTCSPGHGSCDAVSGLCV;PGLDGCDCPEGWTGL;PVTGSCACPPGTT;QCPPGAACHHVTGECR;VDECASGRGGCEHH 21 15.8 0.99682 -5.6956 14.7323 0 9.29048 0 4.59329 10.1235 11.024 5.27691 12.5936 10.0338 6.95478 8.92291 7.26697 5.46359 8.08762 A0A8I3PA52 A0A8I3PA52_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CDC42BPB Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032]; cell migration [GO:0016477] actomyosin [GO:0042641]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] AETAPLPPRPDA;DMARAPQRPPTVPLPTTQPLTL;DWWSLGVCMY;EKEDFHKQLVEAS;ELEKKVLF;EQSKRPLGV;PLRSMSDPDQDFDKEP;SLGVCMYEML;VQRTRPFHRKVN 9 6.1 1.0025 -1.4005 0 0 0 0 0 8.32486 0 0 0 0 7.34926 0 9.21291 0 6.32998 A0A8I3PA53 A0A8I3PA53_CANLF GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) POFUT2 Canis lupus familiaris (Dog) (Canis familiaris) fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; positive regulation of protein folding [GO:1903334]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794] peptide-O-fucosyltransferase activity [GO:0046922] LNRNIPVIEYEQFIA;VLVLPPWGR 2 5.6 1.0037 -1.1081 0 0 0 0 0 0 0 0 2.3854 0 0 0 0 0 0 A0A8I3PA54 A0A8I3PA54_CANLF Gfo/Idh/MocA-like oxidoreductase domain containing 1 GFOD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide binding [GO:0000166] DGRPLTMA;PEKAFSDIPSP 2 4.9 1.0029 -1.3528 0 0 0 0 0 0 0 0 0 0 0 0 0 9.44104 8.82063 A0A8I3PA68 A0A8I3PA68_CANLF Inhibitor of growth protein ING1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606]; regulation of programmed cell death [GO:0043067] nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] HLVNYVEDYLD;KKKKRSKAKAE 2 7.9 0.94151 0.070982 0 0 0 0 0 0 0 0 0 0 0 0 6.09392 8.96402 0 A0A8I3PA74 A0A8I3PA74_CANLF Chromosome 3 open reading frame 18 C20H3orf18 Canis lupus familiaris (Dog) (Canis familiaris) DPTEEQDELEQEL;MVLYIRKKKRLE 2 15.4 0.99082 -0.14685 0 0 0 0 0 0 4.22288 10.318 0 9.80536 10.1549 0 0 0 0 A0A8I3PA81 A0A8I3PA81_CANLF Olfactory receptor family 51 subfamily AI member 5 OR51AI5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LFILLSYAVI;SIKTQQIRRAILKV;VLWFDARR 3 10.1 1.003 -1.7265 0 0 0 0 0 9.00341 0 0 0 0 6.3438 0 0 0 0 A0A8I3PA82 A0A8I3PA82_CANLF SECIS binding protein 2 SECISBP2 Canis lupus familiaris (Dog) (Canis familiaris) selenocysteine insertion sequence binding [GO:0035368] AKKPTSLKKIILKERQERKQQRLQ;DTKALFKKKT;LREVLKHLKLRKLK;PVKAKTKRRLVLGLREVLKHLKLR;SSELALHPCS;TAEGEGVVRSTDAVE;VGIFSYDGAQVSTERLQSPTRPCW;VLGLREVLKHLKLRKLK;VLKHLKLRKLK 9 12.9 1.0036 -1.6369 0 0 5.51393 0 0 0 0 0 0 0 0 0 6.54865 8.32993 10.1482 A0A8I3PA87 A0A8I3PA87_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FSGSKSGSTATLTITG;GWSPLLLTLLAR;VLTQPPSVSAAL;VLTQPPSVSAALG 4 28.1 0.32624 0.61116 0 0 6.64587 8.9867 0 0 0 0 0 0 8.3844 10.1595 0 0 0 A0A8I3PA89 A0A8I3PA89_CANLF polynucleotide adenylyltransferase (EC 2.7.7.19) TENT5D Canis lupus familiaris (Dog) (Canis familiaris) poly(A) RNA polymerase activity [GO:1990817] ACEAEIKTLERYM;QIVLDPMLEFY;VTCFYQPAPYFAA 3 9.5 0.98657 -0.42763 0 0 0 0 0 0 0 9.57363 0 0 0 10.2092 0 8.64613 0 A0A8I3PA94 A0A8I3PA94_CANLF Teneurin transmembrane protein 3 TENM3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] ENEAVMSPEHAM;GVCEPATRRGLAFCAEMGLPHRGYS;KSDSENGV;LVHRETDEYTRQGQN;LYGNRVKDLVHRETDEYT 5 37.4 1.0048 -1.1044 0 0 0 0 0 0 0 0 7.78588 6.88631 0 0 0 0 0 A0A8I3PA95 A0A8I3PA95_CANLF Sodium/potassium-transporting ATPase subunit beta ATP1B4 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transport [GO:0006813]; regulation of DNA-templated transcription [GO:0006355]; sodium ion transport [GO:0006814] nuclear inner membrane [GO:0005637]; sodium:potassium-exchanging ATPase complex [GO:0005890] DLEEEEEEEEEEEEEEEEEEIEEEE 1 6.9 0.9789 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.91313 A0A8I3PA98 A0A8I3PA98_CANLF Nudix hydrolase 16 like 1 NUDT16L1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] snoRNA binding [GO:0030515] LTEGPHRVVAHLYARQLTLEQ 1 10 0.9535 0.050564 8.22603 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PAA5 A0A8I3PAA5_CANLF Actin related protein 1B ACTR1B Canis lupus familiaris (Dog) (Canis familiaris) CAKHPLVGSGVIKAG;DVSRYLRLLLR 2 7 0.99069 -0.2111 0 0 0 0 0 0 0 9.66108 0 0 0 1.66698 0 0 0 A0A8I3PAB4 A0A8I3PAB4_CANLF Lipoyltransferase 1 LIPT1 Canis lupus familiaris (Dog) (Canis familiaris) KIGRTTAY 1 2.1 0.98992 -0.2636 0 0 0 0 0 0 0 0 7.97579 0 0 0 0 0 0 A0A8I3PAD9 A0A8I3PAD9_CANLF Armadillo repeat containing X-linked 4 ARMCX4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEAVFGARVDDKGNT;DEAYAKPKAE;DNSSVLSKTGVGPDTVGS;ESWFRRGE;FCACSESQANARG;FEDLANVEASL;GAENKVNIGSWIRSEEA;NIGSWIRSEEAACMDSCVGAG;NPNTVSRAEVGVDMRSCAPSQAVTK;QAGGGPMLGPEDQS;SNVQLAGLRLIKHLTIISE;TDTKAQSQAATKSQ;VDSGCNTN;VGTGDLYGESKPRF;VLAAEYSDPEVKE 15 8.4 0.99667 -4.3203 10.2037 3.43069 11.8726 0 0 8.93926 8.66452 7.9747 0 8.56331 10.9974 8.14583 2.85957 0 9.16388 A0A8I3PAE2 A0A8I3PAE2_CANLF Uncharacterized protein AQP7 Canis lupus familiaris (Dog) (Canis familiaris) polyol transmembrane transport [GO:0015791] plasma membrane [GO:0005886] channel activity [GO:0015267] LFAITDKENNPALQGTQ 1 5 0.99109 -0.13522 0 0 0 0 10.7561 0 0 0 0 0 0 0 0 0 0 A0A8I3PAE6 A0A8I3PAE6_CANLF Nucleoporin 160 NUP160 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] ARAVDLMTHNYYELLYAFHVFRH;EYAWIVHPASGAVYDRPG;LQDLVEFPYVNLHNEVV;PEKAAEQI;SVTMDMAAVMEMSCYNL;VGLPELVI;YNLQSPEKAAEQILED 7 6.7 1.0029 -0.83779 0 0 9.12817 0 0 0 0 0 0 6.74012 0 5.06096 6.78411 7.66938 0 A0A8I3PAE9 A0A8I3PAE9_CANLF S-arrestin (48 kDa protein) (Retinal S-antigen) (Rod photoreceptor arrestin) SAG Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor internalization [GO:0002031]; signal transduction [GO:0007165] photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] G protein-coupled receptor binding [GO:0001664] EIYFHGEPITVTVTVTNNT;QEETQEKVPPNST 2 8.6 0.99011 -0.2206 0 0 0 0 0 0 0 0 9.86569 0 0 0 0 0 0 A0A8I3PAG3 A0A8I3PAG3_CANLF MGAT4 family member D MGAT4D Canis lupus familiaris (Dog) (Canis familiaris) EFKEKMLLLKN;IKQVLDFCFLM;TDFVRFFLMFYKDK 3 9.6 0.98741 -0.36307 0 0 9.91527 0 0 8.29016 0 0 10.2131 0 0 0 0 0 0 A0A8I3PAG5 A0A8I3PAG5_CANLF Claudin CLDN17 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transport [GO:0015698] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] channel activity [GO:0015267]; structural molecule activity [GO:0005198] EGLWMNCVRQAKIRLQC 1 7.6 0.97589 0.046227 0 0 0 0 0 0 5.33942 0 0 0 0 0 0 0 0 A0A8I3PAG8 A0A8I3PAG8_CANLF Tetraspanin TSPAN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYVFITYDDYDHFFEDV;FLKSQKKKKKKKKKK;FLKSQKKKKKKKKKKK;ILLLVFVTEVVVV;KKKKKKKAGIL;KKKKKKKK;KKKKKKKKAGIL;KKKKKKKKKAGI;KKKKKKKKKAGIL;KKKKKKKKKKA;KKKKKKKKKKAGI;KKKKKKKKKKK;KKKKKKKKKKKA;KKKKKKKKKKKAGIL;KSQKKKKKKKKKKKAG;KSQKKKKKKKKKKKAGI;QKKKKKKK;QTFLKSQKKKKKKKKKKK;SQKKKKKKKKKKKAGIL;TFLKSQKKKKKKKKKKKA 20 19.1 0.53107 0.45204 0 9.76162 5.70041 5.27832 4.14421 0 10.3346 8.58143 0 9.2888 6.72656 3.16891 4.47405 6.42109 6.07528 A0A8I3PAG9 A0A8I3PAG9_CANLF HtrA serine peptidase 1 HTRA1 Canis lupus familiaris (Dog) (Canis familiaris) chorionic trophoblast cell differentiation [GO:0060718]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; placenta development [GO:0001890]; proteolysis [GO:0006508] cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] HDRQAKGKAITKKK;PDTPAEAGGLKEND;PLLLLPLLLL;PLLLLPLLLLAAPAPAPAQPSRAGR 4 10.9 0.99252 -0.17162 0 7.91779 0 0 0 0 0 6.5709 0 0 0 0 0 0 0 A0A8I3PAH5 A0A8I3PAH5_CANLF Solute carrier family 12 member 5 SLC12A5 Canis lupus familiaris (Dog) (Canis familiaris) cell volume homeostasis [GO:0006884]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573] plasma membrane [GO:0005886]; synapse [GO:0045202] potassium:chloride symporter activity [GO:0015379] GSREHEEAENNE;LLRHHKVWRKCKMRIFTVAQMDDN;SPGEEPEGEGEGDP 3 4.5 0.99525 -0.56458 0 0 0 0 0 0 0 0 9.65473 0 0 8.455 0 0 0 A0A8I3PAH7 A0A8I3PAH7_CANLF Armadillo like helical domain containing 3 ARMH3 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020] GEEHPIRVVN;IILTCIAEDQY;IINMLMGFDKAELCMKNLMESLDSL;IRAIINHFNPK;IVDDEATLNYKDKEEEHQSGFFS;LEYLEGKLESLDGEELMKIKDNIN;SGFDIINMLMGFD 7 16 0.9786 0.046279 9.40829 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PAI7 A0A8I3PAI7_CANLF Ubiquinol-cytochrome c reductase complex assembly factor 4 UQCC4 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] VVWCFLRQETGTDRW 1 11.8 0.95143 0.053904 0 0 0 0 0 0 0 0 0 0 0 5.21855 0 0 0 A0A8I3PAK8 A0A8I3PAK8_CANLF Developing brain homeobox 1 DBX1 Canis lupus familiaris (Dog) (Canis familiaris) ventral spinal cord interneuron specification [GO:0021521] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" FSDSEDEEEGEDE;PSDFSDSEDEE;YLPRSLPTASMSP 3 8.5 0.99279 -0.14129 0 0 6.16509 0 0 7.47184 7.85137 9.85915 7.93334 0 0 8.34643 0 0 0 A0A8I3PAK9 A0A8I3PAK9_CANLF NFKB inhibitor interacting Ras like 1 NKIRAS1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical NF-kappaB signal transduction [GO:0043124] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VGGARPGL 1 2.6 0.98992 -0.26592 0 0 0 0 0 0 16.3427 0 0 0 0 0 0 0 0 A0A8I3PAM1 A0A8I3PAM1_CANLF LDL receptor related protein 2 LRP2 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] AYVCDHYLDCEDGSDE;CDDVDDCGDHFDET;CDEDNDCGDMSDE;CDEDNDCGDMSDESP;CDGDADCTDGYDEHQNC;CDGDDDCGDGSDEE;CDGDDDCGDGSDEEL;CDGDDDCGDGSDEELHLCL;CDGDNDCGDM;CDGDNDCGDMSD;CDGDNDCGDMSDE;CDGDNDCGDMSDED;CDGDNDCGDMSDEDE;CDGENDCQ;CIPQDWKCDVDNDCGDY;CNGFDDCRDNSDEQGCE;DEDERHHCESHNCSS;DEPMPECMSHRC;DGDDDCGDGS;DGDDDCGDGSDE;DGDNDCGDM;DHYNDCGDNSDEAGCLF;DHYNDCGDNSDEAGCLFRE;DNDCADGSDEKNCQFTET;DNDCGDYSDEPMPECM;DNDNDCGDGSDELESVCAFHT;DTDNDCADGSD;DVDDCGDHFDETGCNTG;DWKCDVDNDCGDYSDE;DWLCDGDNDCRDMSDEKDCPTQ;DYCDYDGQH;DYSDEPMPECMSHRCDNHTEF;EAWRCDSENDC;ENLCEQNCTQLNEGGFICSC;EQWKCDNDNDCG;ESLTFDWISKNLYWT;ESPINMPPPCRC;GEGQCIPN;GENDCQDN;HCIVDNGTRCDSSKFTCLNGHCI;HDSVTCLKDDQPFL;HFYLCDEDNDCGD;HGVAVGVD;HVYHPYRQ;HYLDCEDG;HYRCDHYNDCGDNSDEAGCL;IDWGALRL;IVVDWVGRNLYWTDYALETI;LDPEVHSPPFQAISV;LDSYLDYIDYCDYDG;LEQWKCDNDNDCG;LLLVASQNQIVADN;LSKGVPPG;LVCDDVDDCGDHFDE;MTHPFGLTVFEDHV;NDTSDEKNCSDRTCQ;NSDERDCE;NSWECDGERDCEDGSDEH;PQDWKCDVDNDCGDYSDEPMPECM;QPIIFENPMYAS;RCIPEAWRCDSENDCG;SSSCSHLCLLSSQRP;SVLSCEYQCHMSPSGGMCYCP;TAFHPFSLTLYGQYIYWTD;TTVAVLLTIILIIIVGALA;TTVAVLLTIILIIIVGALAAL;VLSCEYQCHMSPSGGMC;VLSCEYQCHMSPSGGMCY;WVCDGDADCTDGYDE;YCNRPTHPNGDCSHFC;YLCDEDNDCGDMSDESP 71 13.8 0.99669 -10.514 9.6226 6.63057 10.2477 12.5554 11.209 13.5823 9.63481 10.4997 9.54784 7.00955 10.8388 9.99407 8.71644 11.1464 9.8816 A0A8I3PAM7 A0A8I3PAM7_CANLF Ceramide synthase 6 CERS6 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] GVRFLKKTPWLWNTRHCWYNYP;LSHSEDFGIMFLHH;LTTDLHYYYIL;VLNTTLFESWEIVG 4 9.6 0.9922 -0.54095 9.11476 0 0 0 11.3289 9.10305 14.5903 0 0 0 0 0 0 0 0 A0A8I3PAN0 A0A8I3PAN0_CANLF Centrosomal protein 83 CEP83 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278] centriole [GO:0005814]; ciliary transition fiber [GO:0097539]; Golgi apparatus [GO:0005794] QERITDREEKYNQAK 1 2.1 0.95354 0.053887 0 7.13791 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PAN4 A0A8I3PAN4_CANLF Family with sequence similarity 78 member A FAM78A Canis lupus familiaris (Dog) (Canis familiaris) MPSFLWDCWPSL;PSALVKPNANDAQVL;VLMWRPKYGQPLVVI 3 14.1 0.98749 -0.4623 0 0 9.34032 0 0 0 0 0 9.73383 0 14.1129 0 0 0 9.31936 A0A8I3PAQ5 A0A8I3PAQ5_CANLF Heterogeneous nuclear ribonucleoprotein L like HNRNPLL Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] RNA binding [GO:0003723] FAPRGWKQRRRRRERLNVG;GDGGGGGG;GGDGGGGG;GGGDGGGG;GGGGGGGA;LSGLLEWEC;VLTFIKYKVFD 7 7.6 1.0026 -1.0049 0 9.395 0 0 0 0 10.3636 0 0 5.98092 0 0 2.81576 7.47671 0 A0A8I3PAR1 A0A8I3PAR1_CANLF PDZ and LIM domain protein 3 PDLIM3 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061] adherens junction [GO:0005912]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371] AGSTQKMP;ETLQGQVS;KAHPFKINLESEPQDVNYFEHKH;LPGVKIVH 4 12.9 1.002 -1.4262 0 0 12.3963 0 9.75062 0 0 10.3814 7.6037 0 0 0 8.84266 0 8.56708 A0A8I3PAR4 A0A8I3PAR4_CANLF Insulin receptor substrate 4 IRS4 Canis lupus familiaris (Dog) (Canis familiaris) insulin receptor signaling pathway [GO:0008286] insulin receptor binding [GO:0005158] AAVPALIP;DSAIRYDAETG;EDDPYVPMRPGV;EDEDDPYVPMR;GGKGSGGG;GPKHAVSK;NDDDDDDD;NDDDDDDDDTY;NDDDDDDDDTYVR;QSSGGNQCSGGGQGSG;SDSPRRDCQK;TVIGPGELWMQVD;VAENESEQESW;YSISIGAH 14 9.4 0.99692 -5.5577 0 9.64775 11.5456 8.74039 0 8.15031 13.9688 14.0295 0 10.2103 9.76674 10.7057 10.0836 0 6.0312 A0A8I3PAS1 A0A8I3PAS1_CANLF Sperm associated microtubule inner protein 1 SPMIP1 Canis lupus familiaris (Dog) (Canis familiaris) DMPEMRYLFPITTNFTYGWQL 1 11.9 0.97759 0.047846 0 0 7.89682 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PAS6 A0A8I3PAS6_CANLF Aladin WD repeat nucleoporin AAAS Canis lupus familiaris (Dog) (Canis familiaris) EAHSMVWDPSGE;FAQVTNCTIV;GGVTNLLW 3 5.8 0.99964 -0.61146 8.80142 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PAT5 A0A8I3PAT5_CANLF Innate immunity activator INAVA Canis lupus familiaris (Dog) (Canis familiaris) adherens junction maintenance [GO:0034334]; innate immune response [GO:0045087]; intestinal epithelial structure maintenance [GO:0060729]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of stress-activated MAPK cascade [GO:0032874]; reactive oxygen species biosynthetic process [GO:1903409]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494] cytoplasm [GO:0005737]; nuclear body [GO:0016604] AGGAGAPWDSWGNCRP;KDEVSDTDSGIILQSGPDSPV;WDSWGNCRPPPHPGS 3 6.5 0.98495 -0.4397 0 0 6.55948 0 0 0 0 0 8.7387 10.1893 0 0 0 0 0 A0A8I3PAT8 A0A8I3PAT8_CANLF Dehydrogenase/reductase 9 DHRS9 Canis lupus familiaris (Dog) (Canis familiaris) 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; progesterone metabolic process [GO:0042448] endoplasmic reticulum membrane [GO:0005789] "all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase activity [GO:0047044]; androsterone dehydrogenase activity [GO:0047023]; testosterone dehydrogenase (NAD+) activity [GO:0047035]" APTDWLTVEDYR;GVLAPTDWL 2 4.7 1.0017 -0.75377 0 0 0 0 4.18055 0 0 0 0 0 0 0 0 8.01413 0 A0A8I3PAV4 A0A8I3PAV4_CANLF Stathmin STMN3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of microtubule polymerization or depolymerization [GO:0031110] cytoplasm [GO:0005737]; neuron projection [GO:0043005] tubulin binding [GO:0015631] EAAEERRKTQEA;SPSDLSPESPVL 2 13.3 0.9841 -0.2445 0 0 0 0 7.34527 0 0 0 0 0 0 0 0 0 0 A0A8I3PAV5 A0A8I3PAV5_CANLF Transcobalamin-2 (Transcobalamin II) TCN2 Canis lupus familiaris (Dog) (Canis familiaris) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] cargo receptor ligand activity [GO:0140355]; cobalamin binding [GO:0031419]; metal ion binding [GO:0046872] EYTPKNGE;SIYIGLRLSSL 2 4.4 0.99304 -0.5561 0 0 0 0 0 9.5169 0 0 0 0 0 0 0 0 0 A0A8I3PAX1 A0A8I3PAX1_CANLF Eukaryotic translation initiation factor 5B (Translation initiation factor IF-2) EIF5B Canis lupus familiaris (Dog) (Canis familiaris) regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255] mitochondrion [GO:0005739]; synapse [GO:0045202] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743]; tRNA binding [GO:0000049] AAVEVVEQGVPE;APVICVLGHVDT;DEMQKSDWQLIVELK;EVKENPEEEEEEEEEESEEEESEEE;LEQEKRERKKQKEKERKERLKK;QAQGVEVPSKDSL;QKREEEERIKRLEELEAKRKEEERL;QTMLSKRLAHCEE;VEMYSGSDDDDD;VEMYSGSDDDDDDFN;YEKHKEVE 11 13 1.0019 -1.2894 11.3922 8.53087 0 0 0 8.51239 10.3174 5.55142 5.96461 11.9332 0 6.14578 5.77421 6.28742 5.81806 A0A8I3PAX9 A0A8I3PAX9_CANLF Olfactory receptor LOC119864884 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGIPGLQAFH 1 3.4 0.99964 -0.61146 4.14143 0 0 0 0 0 5.52885 5.89191 0 0 0 0 0 0 0 A0A8I3PAY1 A0A8I3PAY1_CANLF Alpha-galactosidase (EC 3.2.1.-) GLA Canis lupus familiaris (Dog) (Canis familiaris) glycosphingolipid catabolic process [GO:0046479]; oligosaccharide metabolic process [GO:0009311] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764] alpha-galactosidase activity [GO:0004557]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102] MLVIGNFGLSWDQQVTQMALWAIMA;PGARALDNGLAMTPTMGW 2 10.2 0.94342 0.083851 0 6.47246 0 0 0 7.26115 0 0 0 0 0 0 0 0 0 A0A8I3PAY2 A0A8I3PAY2_CANLF Cytochrome P450 family 26 subfamily C member 1 CYP26C1 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; central nervous system development [GO:0007417]; neural crest cell development [GO:0014032]; organelle fusion [GO:0048284]; retinoic acid catabolic process [GO:0034653] endoplasmic reticulum [GO:0005783] heme binding [GO:0020037]; iron ion binding [GO:0005506]; retinoic acid 4-hydroxylase activity [GO:0008401]; retinoic acid binding [GO:0001972] GPWPDCGCEPD;HYIPFGGGARSCLGQELA;IPKGWSVMYSIRD 3 8 0.98393 -0.25349 0 0 0 0 0 10.9231 0 0 0 0 0 0 0 0 0 A0A8I3PAY5 A0A8I3PAY5_CANLF Ig-like domain-containing protein SIGLEC11 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] FLLCAADSNPPAELS;VLAGEGAVLV 2 4.4 0.58333 0.37418 0 0 0 8.48204 8.84599 6.97842 0 0 8.5263 9.45931 0 9.55378 8.93452 9.88477 0 A0A8I3PAZ3 A0A8I3PAZ3_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCL2 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; regulation of synaptic transmission, GABAergic [GO:0032228]" "GABA receptor binding [GO:0050811]; inositol 1,4,5 trisphosphate binding [GO:0070679]; phosphatidylinositol phospholipase C activity [GO:0004435]" AGTEVTKEEFVEVFHELC;GGGGGGGG;GVAHINEEISLEIINK;GVSGDEARASPARGPRG;KSVQFKEFQVSFQVQ;NCSGVEGDVTDEDEG;PKGSGAKG;SNCSGVEG;SYLPSPDV;TYLIEDQFRG;VLKGRILIKAKK;VLKGRILIKAKKL;VLKGRILIKAKKLS;VLKKIVTT 14 13.6 0.99927 -3.078 8.75057 5.1786 16.0336 14.3428 14.4136 0 6.16902 0 9.20415 0 15.642 8.70625 6.73715 0 0 A0A8I3PAZ7 A0A8I3PAZ7_CANLF Collagen type V alpha 3 chain COL5A3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] DNLDPIATGVPQSEPE;GIPTWELFPDGH;GTVIMMPFQFA;IPGEKGLPGLQGPPGFPGPK;KGPPGNPG;MGPHGAPG;PGFPGDPG;PSGRVGREGREGE;VGFLPLWDVAAADFGQT;VLGTQDLGEETFEGDVQELLISPDP 10 8 0.99966 -2.849 0 0 0 6.67412 7.31904 0 12.4042 9.2932 8.46642 0 0 0 0 8.76971 0 A0A8I3PB10 A0A8I3PB10_CANLF Protein phosphatase 1 regulatory subunit 7 PPP1R7 Canis lupus familiaris (Dog) (Canis familiaris) GQQQSQEMMEVDRRVESEESGDEEG;VGCRERGQERSPG;VLSMQSNRLTKMEGLQ 3 10.3 0.91028 0.111 0 0 0 0 7.40344 0 8.51916 5.96248 0 0 0 0 0 0 0 A0A8I3PB13 A0A8I3PB13_CANLF MORC family CW-type zinc finger 2 MORC2 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CSRLIKMYEKVGPQLEG;QRGIIKFWDEFGYLS;TDNVEKFAIETE;YAERREDLRG 4 5.2 0.99704 -0.087415 0 0 9.76353 8.7126 0 0 0 0 0 0 13.9255 0 14.9109 0 0 A0A8I3PB16 A0A8I3PB16_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) DTX1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; glial cell differentiation [GO:0010001]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of T cell differentiation [GO:0045581]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; T cell differentiation [GO:0030217] cytosol [GO:0005829]; nuclear body [GO:0016604] Notch binding [GO:0005112]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270] EKQHPWLDL;NEHSRWRPYTATVCHHIENVLKED 2 5.3 0.99158 -0.27674 0 0 0 0 0 4.60431 0 0 0 0 0 0 0 0 0 A0A8I3PB17 A0A8I3PB17_CANLF Nuclear Testis protein N-terminal domain-containing protein LOC119870860 Canis lupus familiaris (Dog) (Canis familiaris) AEALSCFLIPVLRTLARLK;EDEELPSL;GSPRRPEPPAPWASPP 3 6.3 0.99286 -0.29027 11.6457 0 0 0 0 0 0 4.45595 0 0 0 9.08672 0 0 0 A0A8I3PB27 A0A8I3PB27_CANLF Pleckstrin homology domain containing N1 PLEKHN1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] cardiolipin binding [GO:1901612] LSVFKKGRRRVPVRNLGK;VFKKGRRRVPVRNLGKVIHYAKVQL 2 4.4 0.98484 -0.23902 0 0 0 3.48594 5.99467 0 5.66684 0 0 0 0 0 0 0 6.83857 A0A8I3PB31 A0A8I3PB31_CANLF Mannosidase alpha class 2C member 1 MAN2C1 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GAEGGMRGSAWFLLQISPNSRLSQE;GAQFLYPAAQ;QEPRHSSACALP;VEEVLKTMVKNRDK;VLSLSLLPPG 5 6.6 1.0041 -1.0523 0 9.01237 8.93322 0 0 0 0 0 0 8.95536 0 0 11.0208 11.4695 9.63675 A0A8I3PB32 A0A8I3PB32_CANLF Guanylate cyclase (EC 4.6.1.2) GUCY2C Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of cell population proliferation [GO:0042127]; response to toxic substance [GO:0009636] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; protein kinase activity [GO:0004672] AVVLLLLIALLVLRK;IFPLETNETNHI;ILPPKKDLWTA;LEYLQLNT;TLPPEYSI;VLLLLIALLVLRKYK;VLLLLIALLVLRKYKKEYEL;VVLLLLIALLVLR;VVLLLLIALLVLRKYK 9 5.7 1.0024 -1.3704 8.72028 6.26324 3.98121 0 9.45949 0 0 2.88213 0 0 0 4.29756 0 0 0 A0A8I3PB42 A0A8I3PB42_CANLF Growth differentiation factor 15 GDF15 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to chemical stress [GO:0062197]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; negative regulation of appetite [GO:0032099]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; reduction of food intake in response to dietary excess [GO:0002023]; response to metformin [GO:1901558]; SMAD protein signal transduction [GO:0060395] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803] LVMLSWLPS 1 2.9 0.98261 -0.25143 0 0 0 0 0 10.069 0 0 0 0 0 0 0 0 0 A0A8I3PB48 A0A8I3PB48_CANLF Aldose 1-epimerase (EC 5.1.3.3) GALM Canis lupus familiaris (Dog) (Canis familiaris) galactose metabolic process [GO:0006012] cytoplasm [GO:0005737] carbohydrate binding [GO:0030246]; isomerase activity [GO:0016853] QFYTGNFLDGTL;VLGFAELEGYLQKQPYFG 2 8.8 0.9915 -0.26974 0 0 0 0 0 7.08937 0 0 0 0 0 0 0 0 0 A0A8I3PB52 A0A8I3PB52_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP8 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; dorsal/ventral neural tube patterning [GO:0021904]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; neuron fate specification [GO:0048665]; positive regulation of BMP signaling pathway [GO:0030513]; protein localization to mitochondrion [GO:0070585]; regulation of gene expression [GO:0010468]; regulation of mitophagy [GO:1901524]; smoothened signaling pathway [GO:0007224] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial envelope [GO:0005740]; protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183] ALDLSVPLMDVG;DFEVLDGVED;GVEDAEGEEEEEEEEEEE 3 7.6 0.98831 -0.26453 0 0 10.9096 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PB55 A0A8I3PB55_CANLF Ovo like transcriptional repressor 1 OVOL1 Canis lupus familiaris (Dog) (Canis familiaris) "epidermis development [GO:0008544]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; keratinocyte proliferation [GO:0043616]; kidney development [GO:0001822]; meiotic cell cycle phase transition [GO:0044771]; mesoderm development [GO:0007498]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of meiotic cell cycle phase transition [GO:1901994]; negative regulation of stem cell proliferation [GO:2000647]; skin development [GO:0043588]; spermatogenesis [GO:0007283]; stem cell proliferation [GO:0072089]" nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QKAFTYQRMLNRHMK;TLGDGPSG 2 8.6 0.98949 -0.52995 0 0 0 0 0 0 0 8.2055 10.0362 0 0 0 0 0 0 A0A8I3PB58 A0A8I3PB58_CANLF "B(0,+)-type amino acid transporter 1-like" LOC482987 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; protein-containing complex [GO:0032991] amino acid transmembrane transporter activity [GO:0015171] IDHPQIEFLYI;LPRPYKVPTVI;MKKKNLPRPY;SGIPVYFLLVHFQCQPKWLQ;VVWAVCGLLAMMGAL 5 12.7 1.0044 -1.0919 0 0 8.70995 0 0 0 0 0 0 0 8.45734 0 7.3984 0 0 A0A8I3PB65 A0A8I3PB65_CANLF Coiled coil protein 74 C-terminal domain-containing protein LOC608483 Canis lupus familiaris (Dog) (Canis familiaris) GPAKDEEVETFSTVATSAAGG 1 8.3 0.9844 -0.23989 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.1573 A0A8I3PB66 A0A8I3PB66_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLRLLLVLLLVLLLVLL;GLRLLLVLLLVLLLVLLL;LLFEEPLG;LLLVLLLVLLLVLLL;LLLVLLLVLLLVLLLVRH;LLLVLLLVLLLVLLLVRHG;LLVLLLVLLLVLLLVLLLVRHG;LLVLLLVLLLVLLLVR;LPSSGAASPWTSPPRTP;LRLLLVLLLVLLLVL;LRLLLVLLLVLLLVLLL;LRLLLVLLLVLLLVLLLV;LVLLLVLLLVLLL;LVLLLVLLLVLLLVLLL;LVLLLVLLLVLLLVLLLVRH;LVLLLVLLLVLLLVRH;PGLRLLLVLLLVLLLVLLLVL;PHPPGLRLLLVLLLVLLLVLL;RLLLVLLLVLLLV;RLLLVLLLVLLLVLLL;RLLLVLLLVLLLVLLLV;RLLLVLLLVLLLVLLLVLL;VLLLVLLLVLL;VLLLVLLLVLLL;VLLLVLLLVLLLVLL;VLLLVLLLVLLLVLLL;VLLLVLLLVLLLVLLLV;VLLLVLLLVLLLVLLLVRH;VLLLVLLLVLLLVLLLVRHG;VLLLVLLLVLLLVLLLVRHGH;VLLLVLLLVLLLVR 31 22.6 0.98515 -0.25894 0 0 0 0 15.2209 0 0 0 0 0 0 0 0 0 0 A0A8I3PB68 A0A8I3PB68_CANLF RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] protein serine/threonine phosphatase activity [GO:0004722] PLTQNRSMEVHKIL 1 7.7 0.93722 0.060924 0 0 0 0 0 0 0 0 0 9.23702 0 0 0 0 0 A0A8I3PB86 A0A8I3PB86_CANLF Fibroblast growth factor (FGF) FGF8 Canis lupus familiaris (Dog) (Canis familiaris) dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; limb morphogenesis [GO:0035108]; neuron differentiation [GO:0030182]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] KSNGKGKDCVFTEIVLENN;RVRGAETGLYIC;TEQSLRFEFLNYPP;TYQLYSRTSG 4 25.6 0.98776 -0.35009 0 12.9763 0 0 0 0 10.4116 0 0 0 0 0 0 0 0 A0A8I3PB87 A0A8I3PB87_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCE1 Canis lupus familiaris (Dog) (Canis familiaris) diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; glomerulus development [GO:0032835]; lipid catabolic process [GO:0016042]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of lamellipodium assembly [GO:0010592]; Ras protein signal transduction [GO:0007265] cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435]; small GTPase binding [GO:0031267] ANNEEEEDEEDEYDYDYESLSD;CDDYDALDDKYLCFEDSCQ;DLQLPLSYYYIES;DTKPIVTDYFLMEEK;DYDYESLSDADVL;EDEEDEYDYDYESL;EEDEEDEYDYDYESLSD;EEEDEEDEYDYDYESLSDAD;EEEEDEEDEYDYDYE;GLTSSQVLASESVQ;INSDLPIIISI;KHTAKMLF;LIDLQPLIQ;LRRKVLLKNKKLKAHQTPV;MKLCPRYNSQE;NNEEEEDEEDEYDYDYESL;NNEEEEDEEDEYDYDYESLSD;PSPDQLRRKVLLKNKKLKAH;QLRRKVLLKNKKLKAHQT;TKKKKKILI;VDYLYFLTRD 21 7.3 0.92857 0.10781 0 10.2691 0 0 4.89322 0 0 0 0 0 0 0 0 0 0 A0A8I3PB91 A0A8I3PB91_CANLF Olfactory receptor LOC119864130 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DLFPLLKLSCTDTHIFGL;SFIDSCCSS 2 8.1 1.0029 -0.7559 0 0 0 0 12.0623 13.2204 0 0 0 0 0 0 0 0 10.1694 A0A8I3PB93 A0A8I3PB93_CANLF Vacuolar protein sorting-associated protein 54 VPS54 Canis lupus familiaris (Dog) (Canis familiaris) "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; GARP complex [GO:0000938] DIVMKLADQMRMLNF;DLLPEEQTQ;LVDSISGGKIALP;SSDSVSEPECTTDS;SSSATPGG;VGLKTITT;VVGTVLLLIRIIL 7 8.3 0.99731 -3.4315 0 0 8.61154 0 5.1162 0 0 10.9761 0 9.00276 5.21645 9.70527 0 2.88104 0 A0A8I3PB96 A0A8I3PB96_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AASSYLSLTPDK;ASSYLSLTPDK;GVETTKPSKQSNNKYAASSY;KADGSPITQGVE;KADGSPITQGVETTK;KYAASSYLSLTPDK;NKYAASSY;NKYAASSYL;NKYAASSYLSLTPDK;NNKYAASSY;NNKYAASSYL;QSNNKYAASSYLSLTPDK;SNNKYAASSY;SNNKYAASSYL;SNNKYAASSYLSLTPDK;SPITQGVETTK;SPITQGVETTKPSKQ;SPITQGVETTKPSKQSNNKYAASSY;SSYLSLTPDK;STVEKKVAPA;SYLSLTPDK;TTKPSKQSNNKYAASSY;TTKPSKQSNNKYAASSYLSLTPDK;VETTKPSKQSNNKYAASSY;VETTKPSKQSNNKYAASSYL;YAASSYLSLTPDK;YLSLTPDK 27 43.4 0 1.4517 10.4951 10.0481 11.0655 0 0 0 0 0 0 8.47257 8.37912 8.37578 9.17844 0 9.90845 A0A8I3PBA0 A0A8I3PBA0_CANLF Carboxylic ester hydrolase (EC 3.1.1.-) BCHE Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nuclear envelope lumen [GO:0005641] acetylcholinesterase activity [GO:0003990]; identical protein binding [GO:0042802] GFSKDNDSIITRKEFQEGLKMYFP;TILSIRLLLWFLLLW;WRAGFYRWNNYMMDWKNQFNDYTS 3 10.5 0.86767 0.13648 0 7.84204 0 0 0 0 0 7.70922 0 0 0 0 0 0 7.72799 A0A8I3PBA6 A0A8I3PBA6_CANLF SH3 domain-binding glutamic acid-rich-like protein SH3BGRL Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886] SSSGSTAI 1 7 1.0036 -1.1044 0 0 0 0 0 10.1874 0 0 0 0 0 0 0 0 0 A0A8I3PBB7 A0A8I3PBB7_CANLF HAUS augmin like complex subunit 7 HAUS7 Canis lupus familiaris (Dog) (Canis familiaris) EEEKVMELARQ;ELGECCQRPGPYLHPC;GGGGGHKA;GGGGHKAG;VECFAQQKQGAAVSGADTSTL;VLASHTAP 6 16.5 1.003 -2.4251 0 0 0 0 0 0 9.84926 0 0 11.2776 9.74265 12.8268 0 0 0 A0A8I3PBC6 A0A8I3PBC6_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) QELKEYVTSEPA 1 3.9 0.94546 0.05044 0 0 0 0 7.34003 0 0 0 0 0 0 0 0 0 0 A0A8I3PBD1 A0A8I3PBD1_CANLF Zinc finger MYND-type containing 8 ZMYND8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] AADIAKYTSKIRRLRIEI;EEEIKTEQEV;EGDWFCPECE;EVNTETLNKSSQ;LGLDSDSESELVI;SPVKKQRPLLPKE;TAGSQSPPETPLLTRSSSQTPTAG;VIDLGEDHSG;YCWVCHREGQVLCCELC 9 11.2 0.99084 -0.2747 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.49538 A0A8I3PBE4 A0A8I3PBE4_CANLF G protein-coupled receptor 17 GPR17 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of inflammatory response to antigenic stimulus [GO:0002862] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] FLMHLAVADLSCVLVLPTRLV;LDPVMYFFVAE;LVCFVPYHVHRA 3 13 0.99023 -0.20104 0 0 0 0 0 0 0 0 9.68449 0 0 0 0 0 0 A0A8I3PBE8 A0A8I3PBE8_CANLF WWC family member 3 LOC119868748 Canis lupus familiaris (Dog) (Canis familiaris) AQAIMSELHTI;GVSHLHGHTCAGQADPYNPKI;LHKMCEDDSRSY;PPPTPPELPVLS;QRKARQVREVPREPPPT;VLQDEQFQSLLKEAERQ 6 7.6 1.0001 -0.6153 0 0 0 0 10.9289 0 10.5594 5.4614 0 0 0 4.90029 0 0 0 A0A8I3PBE9 A0A8I3PBE9_CANLF Spondin-1 (F-spondin) SPON1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of protein processing [GO:0010954]; protein processing [GO:0016485] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] LBD domain binding [GO:0050693]; metal ion binding [GO:0046872] AALAFSDETLDK;ADLAPEEKDED;CSDEDGSTCTMSEW;DCCACGTAK;EETQFMSNCPVAVTEST;ELTEWSQWSECNKSC;GGAPCPET;LDCCACGT;PWDAGTDSGVTYES;WSDCSVTCGK 10 13.8 0.99662 -4.2204 0 0 13.2948 7.20604 8.96547 11.8714 10.6199 0 13.577 14.0436 7.96174 0 0 20.2482 20.3804 A0A8I3PBF5 A0A8I3PBF5_CANLF IKAROS family zinc finger 2 IKZF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] HCTLTMETEAIDGYITC;LDSTDSESSHDDHQSYQG;RKSSTPQKFV 3 8.5 0.99406 -0.17431 0 0 0 0 7.1916 2.97772 0 0 12.0963 0 0 0 0 0 0 A0A8I3PBG2 A0A8I3PBG2_CANLF Rho-GAP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] SFASFPSRRFNT 1 2.7 0.99268 -0.14398 10.4598 0 0 0 0 0 0 0 0 0 0 0 0 0 9.94484 A0A8I3PBH4 A0A8I3PBH4_CANLF Kelch like family member 17 KLHL17 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ASCSPYFHAMFTNEMSE;HDIDPQALD;RSERPAGRTQ;SMSTRRARVGV 4 7.3 1.0028 -1.3414 0 10.8532 9.1821 0 0 0 0 8 0 0 0 0 0 0 7.40463 A0A8I3PBH5 A0A8I3PBH5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] TLTEMRGTVQSLEINLDSMRK 1 9.6 0.98515 -0.24044 0 0 0 0 0 0 0 0 10.0896 0 0 0 0 0 0 A0A8I3PBI3 A0A8I3PBI3_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PQTQGLNRYHDDTKLISFNSNSERE;SETVLSPTELQNLD 2 11.6 0.99217 -0.29502 0 9.67689 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PBJ7 A0A8I3PBJ7_CANLF Uncharacterized protein LPCAT4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] O-acyltransferase activity [GO:0008374] LGKVLRKAGLSPGRVDAG;VAGLTEEQLQEPITG 2 6.8 0.86935 0.13708 0 0 0 0 12.9228 0 5.87234 0 0 3.32625 0 0 0 0 0 A0A8I3PBK4 A0A8I3PBK4_CANLF 5'-AMP-activated protein kinase subunit gamma-1 PRKAG1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] cytoplasm [GO:0005737]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634] AMP binding [GO:0016208]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887] RSHYFEGVLKCYLHETLE 1 6.5 0.97961 0.048313 0 0 0 0 0 0 0 8.58984 0 0 0 0 0 0 0 A0A8I3PBN4 A0A8I3PBN4_CANLF von Willebrand factor C domain containing 2 like VWC2L Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of BMP signaling pathway [GO:0030514] AMPA glutamate receptor complex [GO:0032281]; extracellular space [GO:0005615] PKCTKVEH 1 6.1 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 10.5928 0 0 0 A0A8I3PBN6 A0A8I3PBN6_CANLF NFKB activating protein NKAP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of alpha-beta T cell differentiation [GO:0046638] cytosol [GO:0005829]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729] KDSQEEFLEN;RRSKKAKKKEK 2 5 0.98678 -0.23151 0 0 0 0 2.62831 0 0 0 0 0 0 9.19153 0 0 0 A0A8I3PBP9 A0A8I3PBP9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) "proton-transporting V-type ATPase, V0 domain [GO:0033179]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" FYLFWLIVI 1 15 0.99031 -0.26748 0 0 0 0 0 0 0 0 10.5869 0 0 0 0 0 0 A0A8I3PBR4 A0A8I3PBR4_CANLF Kinesin family member 13B KIF13B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AAGAPGDGGP;DDEHDISMKNETSSEQLDVDGDSS;DERVYLIVRVTVQLS;DESVREKYAGQD;DFIEHLSEGALAI;ELKDRLEESEKLIQEMT;KKADREDDEHDI;LESLFYDVKLQ;MVKILQATGLPQ;QDLIPSYSLGSNKGRWE;SEVSSEINFNYEYAQM;SVNITEDFIE;TFHEEEEDMDSYQDRD;TKCVVDVDEN 14 9.4 1.0031 -1.7265 8.87341 6.29098 14.2111 4.31687 0 0 0 10.2953 9.71258 15.4548 8.17453 0 0 9.76944 0 A0A8I3PBR5 A0A8I3PBR5_CANLF Meiosis 1 associated protein M1AP Canis lupus familiaris (Dog) (Canis familiaris) meiosis I [GO:0007127]; spermatogenesis [GO:0007283] DIRSNLCEALQNFFSL;LLVKAVATRELLLP;SLYVVQNQH 3 7.4 0.98781 -0.46221 0 0 0 0 0 0 10.906 0 0 0 0 0 5.43706 0 0 A0A8I3PBR8 A0A8I3PBR8_CANLF Uncharacterized protein LOC102157101 Canis lupus familiaris (Dog) (Canis familiaris) EDSGMKLLCEG;GRFDYLIYVNCREIN;LKKVKGSA;VLFEVSDLRRH;VLQGCAGI;YLFYFSKCLKTL 6 6.2 0.9871 -0.35544 11.245 0 10.1126 0 9.99421 0 9.47602 10.8007 0 0 0 0 0 0 0 A0A8I3PBS0 A0A8I3PBS0_CANLF Sidoreflexin SFXN3 Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300] mitochondrial membrane [GO:0031966] L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075] GVVTPGLTEDQLW;SLHVSRLEPELRAQIREQNPDIEVV;VFATPLCCALFP 3 15.4 0.9906 -0.51126 10.5852 0 0 0 0 0 0 0 0 0 0 6.00054 0 0 0 A0A8I3PBS5 A0A8I3PBS5_CANLF Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) FAIM2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic signaling pathway [GO:2001234] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] EATSGEGLKAGPF;RRVFIRKVYTILLIQLLVT;VRRVFIRKVYTILLIQL 3 11.5 0.99155 -0.54487 0 0 4.75216 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PBU1 A0A8I3PBU1_CANLF Olfactory receptor OR2W11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVALLLVPLSLILIS;TIIYMYLQ 2 7.3 0.95315 0.053874 0 0 4.67486 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PBU8 A0A8I3PBU8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LVLLIMPLLVP;VGLLVLLIMPLLVPPVAAE;VPPVAAELPGG 3 18 0.98823 -0.49096 0 0 3.97214 0 0 0 0 0 9.93084 0 0 0 0 0 0 A0A8I3PBV4 A0A8I3PBV4_CANLF "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" COQ2 Canis lupus familiaris (Dog) (Canis familiaris) glycerol metabolic process [GO:0006071]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] mitochondrial inner membrane [GO:0005743] 4-hydroxybenzoate decaprenyltransferase activity [GO:0002083] AVVNSAPRPLQPYLRL 1 4.3 0.98323 -0.24801 0 0 0 0 0 0 0 0 11.1197 0 0 0 0 0 0 A0A8I3PBV7 A0A8I3PBV7_CANLF Potassium voltage-gated channel subfamily C member 3 KCNC3 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] GPLFEEELGFWG;KATGAPPL;LTIAMPVPVIV;VVRFVRILRIFKLTRHFV 4 6.4 1.0024 -0.7673 0 0 0 0 0 0 10.1935 0 0 0 0 0 0 0 0 A0A8I3PBV8 A0A8I3PBV8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SNRK Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGPGPGEL;EALETNRYNHITATYFLLAE;EEGESDDEFDMDE;HEEGLNEDLAKKYFAQIVHAISYCH;QGRGSSCSSSETSDDDSES 5 11.2 0.99381 -0.072721 0 0 10.6178 0 0 0 0 9.62863 0 0 0 5.61727 0 0 0 A0A8I3PBX3 A0A8I3PBX3_CANLF Nucleolar protein 4 like NOL4L Canis lupus familiaris (Dog) (Canis familiaris) DDDDDDHDDHEDNDK;EQDETSVSSEDFDMNDS;MKLRVMNSQE;PTADDDDDDHDDH;PTADDDDDDHDDHEDND;VSGIIDYNMPL 6 8.5 0.99535 -0.018169 0 0 0 9.39731 0 4.93683 8.48728 8.80626 0 0 0 7.9472 0 5.77017 0 A0A8I3PBX5 A0A8I3PBX5_CANLF Frizzled class receptor 5 FZD5 Canis lupus familiaris (Dog) (Canis familiaris) "angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic camera-type eye morphogenesis [GO:0048596]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; Spemann organizer formation [GO:0060061]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]" bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] AGCSPLMRQYGFAWPER;CACPGPDA;PSLLLLLLAQL;VPILKESH;YTVPASIVVACYLYEQ 5 10.2 1.0031 -2.2646 0 0 0 0 0 0 9.07508 0 5.66829 3.34255 0 0 0 10.6426 6.12195 A0A8I3PBX6 A0A8I3PBX6_CANLF Gamma-sarcoglycan SGCG Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle tissue development [GO:0048738]; heart contraction [GO:0060047] cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] FVLLLLIILLVNFALTIWIL;GRTRGWTRGWTRGWTRGW;LFVLLLLIILLV;VLLLLIILLVNFALTIWILKV 4 8.1 0.9976 -0.098677 0 3.789 0 0 0 5.80067 12.399 0 0 0 0 0 0 4.24937 0 A0A8I3PBX9 A0A8I3PBX9_CANLF Ragulator complex protein LAMTOR5 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764]; Ragulator complex [GO:0071986] KLTPDPTDIPVVC;PIAGVLCTDSQG 2 28.7 0.9827 -0.24852 0 0 0 0 0 0 0 0 0 0 0 2.51879 0 0 0 A0A8I3PBY0 A0A8I3PBY0_CANLF Lysosome-associated membrane glycoprotein 2-like luminal domain-containing protein LAMP3 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765] FDFEDDHFGNVDECSSD;MGIELMVQDTKSVF;PSTLSHKTRKTTHFGNQTTLPATL;VVMFETGV 4 14.7 0.99273 -0.55497 0 0 0 0 6.84285 0 0 0 0 0 0 0 10.6758 0 10.6519 A0A8I3PBY1 A0A8I3PBY1_CANLF Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19) MED19 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] PERKRKKKEKKKKK;STELTGSTNLITHYNLE 2 11.9 0.86389 0.17482 0 5.11203 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PBY3 A0A8I3PBY3_CANLF Golgi associated kinase 1A GASK1A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CDAESPGMLTSL;CVEERLREKCRNP;GPPWHDDPIGE 3 6.8 0.98908 -0.50713 0 0 0 0 0 0 0 0 0 0 0 8.65675 0 0 0 A0A8I3PBY5 A0A8I3PBY5_CANLF Armadillo repeat containing X-linked 2 ARMCX2 Canis lupus familiaris (Dog) (Canis familiaris) PGAHTGAI 1 1.3 0.98996 -0.26592 0 11.8043 0 0 0 0 0 0 0 0 0 0 12.1312 0 0 A0A8I3PBY8 A0A8I3PBY8_CANLF Uncharacterized protein TEX13B Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EAKEACAWSSL 1 2.6 0.98383 0.035491 8.02436 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PBY9 A0A8I3PBY9_CANLF Glycine N-acyltransferase-like protein (EC 2.3.1.-) GLYAT Canis lupus familiaris (Dog) (Canis familiaris) response to toxic substance [GO:0009636] mitochondrion [GO:0005739] glycine N-acyltransferase activity [GO:0047961] LLDVKKLAPGGGKPKPI 1 5.8 0.97745 0.046227 0 0 0 3.8487 0 0 0 0 0 0 0 5.28995 5.51229 0 0 A0A8I3PC07 A0A8I3PC07_CANLF Serine rich and transmembrane domain containing 2 SERTM2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] VISPITSESTESVPQ 1 16.9 0.99581 -0.08549 0 0 0 0 0 0 0 0 12.7618 0 0 0 0 0 0 A0A8I3PC11 A0A8I3PC11_CANLF Carboxypeptidase B1 CPA3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] FMDCGIHAREWISP;ILIHDLQEEIEKQFDVK 2 7.4 0.87734 0.12642 9.21415 0 0 0 0 0 10.425 0 0 0 0 0 0 0 0 A0A8I3PC14 A0A8I3PC14_CANLF inorganic diphosphatase (EC 3.6.1.1) LOC481394 Canis lupus familiaris (Dog) (Canis familiaris) phosphate-containing compound metabolic process [GO:0006796] cytoplasm [GO:0005737] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] PGYLEATLNWFRFYKVPEG;QENNTEDQMWHFL;TIWQYGQHP 3 13.3 0.9919 -0.18484 0 0 0 0 0 0 8.38828 0 0 0 0 0 0 9.31338 0 A0A8I3PC22 A0A8I3PC22_CANLF Gamma-aminobutyric acid type A receptor subunit alpha5 GABRA5 Canis lupus familiaris (Dog) (Canis familiaris) "associative learning [GO:0008306]; behavioral fear response [GO:0001662]; cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" cell body [GO:0044297]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507] AAKVKKKRELI;LLFCISMNLASHFG;TVILSQVSFWLNRESVP 3 9.1 0.99248 -0.19223 0 0 0 3.94851 6.7086 0 0 0 0 0 0 0 0 0 0 A0A8I3PC28 A0A8I3PC28_CANLF Uncharacterized protein SOWAHD Canis lupus familiaris (Dog) (Canis familiaris) PGPKASLVA;RLSEERAEEQSP 2 6.4 0.99311 -0.04542 0 6.12747 0 7.5741 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PC30 A0A8I3PC30_CANLF Zic family member 2 ZIC2 Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GAGGGGGG;GGGGGGGA;GGGGGGGG;GGGGGGSG;SGGGGGGA;SSPAASSGYE;THPSSLRKHMK 7 8.9 0.99043 -0.53509 0 0 0 0 10.4223 0 0 0 0 0 0 0 0 0 0 A0A8I3PC31 A0A8I3PC31_CANLF Septin 12 SEPTIN12 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] QINNDKCLRPLDIE 1 4.5 0.98996 -0.21988 0 0 0 0 0 0 0 0 0 0 9.35533 0 0 0 0 A0A8I3PC44 A0A8I3PC44_CANLF Round spermatid basic protein 1 like RSBN1L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] FENSNKDLKEELCPGSL;KKVKKKKKKK;KKVKKKKKKKHKENEKR;LQIKKVKKKK;LQIKKVKKKKKK;LQIKKVKKKKKKK;LQIKKVKKKKKKKH;QIKKVKKKKKK;QIKKVKKKKKKK;TLSSLKLESRKD 10 5.9 1.0038 -1.1042 0 4.9182 5.21109 0 0 0 9.36295 5.75918 7.11103 0 7.08746 10.5402 6.35 4.51526 0 A0A8I3PC47 A0A8I3PC47_CANLF BCL2 interacting protein like BNIPL Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; regulation of growth rate [GO:0040009] cytosol [GO:0005829]; nucleus [GO:0005634] identical protein binding [GO:0042802] ETPSDSEQLDSGHEFEWED 1 5.3 0.95485 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.03617 A0A8I3PC48 A0A8I3PC48_CANLF V(D)J recombination-activating protein 1 (EC 2.3.2.27) (EC 3.1.-.-) RAG1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; chromatin organization [GO:0006325]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151] nucleus [GO:0005634] endonuclease activity [GO:0004519]; histone binding [GO:0042393]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AEFYKIFQLE;KYRYEGKITNYFHKTLAHVPEI 2 3.1 0.99524 -0.56453 0 0 0 6.68566 9.89822 0 0 0 0 0 0 0 0 0 0 A0A8I3PC60 A0A8I3PC60_CANLF C-type lectin domain-containing protein LOC102156778 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] DIVRLEGS;GTEDDPEEEGAVECDS 2 10.9 0.86288 0.14572 0 0 11.351 0 11.4601 0 5.16475 0 0 0 11.4982 11.2566 0 0 10.9667 A0A8I3PC61 A0A8I3PC61_CANLF Galactose mutarotase (Aldose 1-epimerase) GALM Canis lupus familiaris (Dog) (Canis familiaris) galactose metabolic process [GO:0006012] carbohydrate binding [GO:0030246]; isomerase activity [GO:0016853] QFYTGNFLDGTL;SDVVLGFAELEGEVA 2 13.9 0.9515 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.26259 A0A8I3PC62 A0A8I3PC62_CANLF Small ribosomal subunit protein eS10 (40S ribosomal protein S10) Canis lupus familiaris (Dog) (Canis familiaris) cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] EQFAWRHFYCYLTNEGIQYLRDYLH 1 15.2 0.97874 0.035538 0 9.23532 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PC67 A0A8I3PC67_CANLF 5-hydroxytryptamine receptor 2B (Serotonin receptor 2B) HTR2B Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cellular response to temperature stimulus [GO:0071502]; cGMP-mediated signaling [GO:0019934]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor internalization [GO:0002031]; heart morphogenesis [GO:0003007]; intestine smooth muscle contraction [GO:0014827]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; neural crest cell migration [GO:0001755]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; phosphorylation [GO:0016310]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell division [GO:0051781]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; protein kinase C signaling [GO:0070528]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; vasoconstriction [GO:0042310] cytoplasm [GO:0005737]; G protein-coupled serotonin receptor complex [GO:0098666]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] G-protein alpha-subunit binding [GO:0001965]; Gq/11-coupled serotonin receptor activity [GO:0001587]; GTPase activator activity [GO:0005096]; serotonin binding [GO:0051378] DTLLITENEGDKT;HLIFANWSGLQTE;ITCVLTKDRFG;RASKVLGIVFFLFLLMWC 4 11.5 0.98754 -0.4663 0 0 5.29771 0 8.3466 0 0 0 0 0 0 0 0 0 8.05284 A0A8I3PC77 A0A8I3PC77_CANLF Monoglyceride lipase MGLL Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol metabolic process [GO:0006639] GERMVVSDFHVFIRDVLQHVDFMQK;MWVSQRIGAAAGTGSP;SAIAILTAAERPSHF 3 18.4 0.95567 0.053881 0 0 0 0 0 0 8.55857 0 0 0 0 0 0 0 0 A0A8I3PC82 A0A8I3PC82_CANLF Uncharacterized protein ACAD9 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] EAAMVKVFSSE;EINQFVGPLE;IRVGLRNHDHEVLL 3 6 1.0045 -0.81962 0 0 0 0 0 0 9.5049 0 6.05617 0 0 0 0 0 0 A0A8I3PC84 A0A8I3PC84_CANLF Keratin-associated protein LOC100855866 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CHTSCSEGCQPACC 1 9.7 0.93257 0.060769 0 0 0 0 5.17756 0 0 0 0 0 0 0 0 0 0 A0A8I3PC89 A0A8I3PC89_CANLF "Proteoglycan 3, pro eosinophil major basic protein 2" PRG3 Canis lupus familiaris (Dog) (Canis familiaris) basophil activation [GO:0045575]; histamine biosynthetic process [GO:0001694]; immune response [GO:0006955]; leukotriene biosynthetic process [GO:0019370]; negative regulation of translation [GO:0017148]; neutrophil activation [GO:0042119]; positive regulation of interleukin-8 production [GO:0032757]; superoxide anion generation [GO:0042554] DPLLLLLLLL;LLLLLLLL 2 4.4 0.99993 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.45667 A0A8I3PC90 A0A8I3PC90_CANLF Cilia- and flagella-associated protein 97 CFAP97 Canis lupus familiaris (Dog) (Canis familiaris) EGEDDYYTDGEESSDD 1 3.1 0.95552 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 7.52176 0 A0A8I3PC91 A0A8I3PC91_CANLF Dedicator of cytokinesis 6 DOCK6 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] DEMEHEAL;EQHKRKTLLS;ETQRERQKGL;FAEGPGQRSRLAS;LDMKARLE;LSAAYSPITTETQ;LVDGNLATEASL;PAREVYAPH;QEAERLSDEDLFKFL;SECCEPYMVM;TILTYAEEDVGLRDSTFAEQVQ;TLIPILEAHRDYK;TTQSFSEEHLRRSL;TTQSFSEEHLRRSLKTILT 14 7.5 1.0035 -2.2554 11.7897 0 9.29902 8.81868 0 0 13.6256 10.8897 10.7228 0 0 0 0 0 6.43884 A0A8I3PC94 A0A8I3PC94_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DECHIKNPPA;LRSKILILLIS 2 15.9 0.99025 -0.21698 0 0 0 0 0 0 0 0 0 0 10.4684 0 3.96033 0 0 A0A8I3PC96 A0A8I3PC96_CANLF NUT midline carcinoma family member 1 NUTM1 Canis lupus familiaris (Dog) (Canis familiaris) AEKFLEFE;PRAVQEWEHTSNFDRMIFYEMAEKF;SHSGSDEDEDGG;SRGDVTLKPG 4 9.8 0.99166 -0.27577 0 0 0 0 0 0 0 0 0 0 0 9.21121 0 0 0 A0A8I3PCA4 A0A8I3PCA4_CANLF Glycine N-acyltransferase-like protein (EC 2.3.1.-) GLYAT Canis lupus familiaris (Dog) (Canis familiaris) glycine metabolic process [GO:0006544] mitochondrion [GO:0005739] glycine N-acyltransferase activity [GO:0047961]; glycine N-benzoyltransferase activity [GO:0047962] IVYTMPERAR;SSLDVTHAALVNKFWYFGGN 2 10.2 0.99426 -0.56147 0 0 0 0 0 0 7.0258 0 10.1047 0 0 0 0 0 0 A0A8I3PCA5 A0A8I3PCA5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VGAKVLLKCSQNMDHERMFWYRQDP 1 22.1 0.97948 0.035538 0 0 0 0 0 0 0 0 7.72288 0 0 0 0 0 0 A0A8I3PCB7 A0A8I3PCB7_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) PPIB Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] HVVFGKVLEGMEV;RFPDENFKLKHYGPG 2 13 0.98924 -0.26556 0 0 0 0 0 0 12.1656 0 0 0 0 0 0 0 0 A0A8I3PCD7 A0A8I3PCD7_CANLF CD86 molecule CD86 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLTLRKRKKKQ;FLTLRKRKKKQPGPSH;KGLYQCFVHHKGP;SDLSVLANFSQ;YHETERSDEAQCV 5 16.8 0.98788 -0.34212 0 0 9.15284 0 0 0 0 0 0 10.3404 0 9.54861 10.5032 0 0 A0A8I3PCE0 A0A8I3PCE0_CANLF XK-related protein XKR7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CALLVFFSDGATDLW;GATDLWLAASYYLQG;YELRDCCWV 3 5.7 1.0019 -0.99343 9.94859 5.47392 0 0 0 0 0 7.34616 0 0 0 0 0 0 0 A0A8I3PCE5 A0A8I3PCE5_CANLF Proteasome subunit alpha type PSMA2 Canis lupus familiaris (Dog) (Canis familiaris) proteasomal protein catabolic process [GO:0010498]; response to virus [GO:0009615]; ubiquitin-dependent protein catabolic process [GO:0006511] "nucleus [GO:0005634]; P-body [GO:0000932]; proteasome core complex, alpha-subunit complex [GO:0019773]" RGYSFSLTTFSP;RVLVHRARKLAQQYYLV 2 12.4 0.9902 -0.53361 0 0 0 0 0 0 9.94845 0 0 0 0 0 0 0 0 A0A8I3PCE6 A0A8I3PCE6_CANLF Uridine-cytidine kinase (EC 2.7.1.48) UCKL1 Canis lupus familiaris (Dog) (Canis familiaris) CTP salvage [GO:0044211]; UMP salvage [GO:0044206] ATP binding [GO:0005524]; kinase activity [GO:0016301] ETMEPALRAVCKD;FDQYIQPTMRVADIVVPW 2 5.8 0.9927 -0.20649 8.41671 0 0 0 0 0 0 0 0 10.9044 0 0 0 0 0 A0A8I3PCG1 A0A8I3PCG1_CANLF Fibrinogen C-terminal domain-containing protein FGL2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of defense response to virus [GO:0050687]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of macrophage antigen processing and presentation [GO:0002617]; negative regulation of memory T cell differentiation [GO:0043381]; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:0002291] ETYRVTPDPKNSSF;PAGWCWLGPVLA 2 5.9 0.99403 -0.079469 0 0 0 0 0 0 0 0 0 0 0 0 0 9.75581 10.2651 A0A8I3PCG4 A0A8I3PCG4_CANLF Activating transcription factor 7 interacting protein ATF7IP Canis lupus familiaris (Dog) (Canis familiaris) DLVETISEN;GPSQTTIHL;NSVTVRVPQ;QPVSRPLQPIQP;RSCATVDSYHLYAYH;SDLPPENEKKVKEDA;SLPALPNP;SLVTPPTVVSS;TDEIIPIL 9 7.6 0.99703 -3.6395 9.02389 0 0 0 0 0 0 0 9.34276 7.3679 9.66926 0 9.94553 11.8313 0 A0A8I3PCJ0 A0A8I3PCJ0_CANLF Immunoglobulin V-set domain-containing protein LOC119873404 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] LFLPVVRGSPAL 1 6.6 0.99634 -0.086024 0 12.2533 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PCJ1 A0A8I3PCJ1_CANLF Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) PAMR1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] FLQLLLISSLPREYTVI;GAEWNIMCRECCEYDQIECVC;GVYCAECRAGWYGGDCMPC;YGGDCMPCSSSPCF;YVLSGNEKRTCQQ 5 12.5 0.98627 -0.42154 0 0 0 0 0 8.36383 0 0 0 0 8.75639 0 11.124 0 0 A0A8I3PCK7 A0A8I3PCK7_CANLF Pyroglutamylated RFamide peptide QRFP Canis lupus familiaris (Dog) (Canis familiaris) grooming behavior [GO:0007625]; locomotory behavior [GO:0007626]; neuropeptide signaling pathway [GO:0007218]; positive regulation of blood pressure [GO:0045777]; regulation of feeding behavior [GO:0060259] extracellular region [GO:0005576] neuropeptide hormone activity [GO:0005184]; orexigenic neuropeptide QRFP receptor binding [GO:0031854] SGRQRAGFRFRFGRQDDGSEAT 1 16.2 0.97486 0.047062 0 0 0 0 0 0 0 0 0 0 7.78477 0 0 0 0 A0A8I3PCL1 A0A8I3PCL1_CANLF Exosome complex component RRP45 (Exosome component 9) EXOSC9 Canis lupus familiaris (Dog) (Canis familiaris) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; positive regulation of cell growth [GO:0030307]; rRNA catabolic process [GO:0016075]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; nuclear chromosome [GO:0000228]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] mRNA 3'-UTR AU-rich region binding [GO:0035925] EGIENSWGDLEE;LVDPNEREERV;QEKAPSKKPVKKRKKKR;SKKPVKKRKKKRA 4 9.7 0.99381 -0.073785 4.07895 0 0 9.52032 9.84751 2.19525 4.3365 0 0 0 3.8509 0 2.38758 0 4.15623 A0A8I3PCL5 A0A8I3PCL5_CANLF Ubiquitin-protein ligase E3A (EC 2.3.2.26) UBE3A Canis lupus familiaris (Dog) (Canis familiaris) androgen receptor signaling pathway [GO:0030521]; negative regulation of TORC1 signaling [GO:1904262]; ovarian follicle development [GO:0001541]; positive regulation of Golgi lumen acidification [GO:1905528]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; prostate gland growth [GO:0060736]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to progesterone [GO:0032570]; sperm entry [GO:0035037] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; proteasome complex [GO:0000502] transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] GTWGYHQFLALLSET;IIAKNGPDTERLPTSHTCFNVLLL;LDCRKPLIPF;LVRLEMIAMENPAD;VLEMDKDYTFF 5 8.1 0.99262 -0.15101 0 0 0 9.38256 0 0 9.29935 0 8.47379 0 0 0 7.11624 0 0 A0A8I3PCL6 A0A8I3PCL6_CANLF Coiled-coil domain containing 62 CCDC62 Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835]; cellular response to estradiol stimulus [GO:0071392]; positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; nucleus [GO:0005634] nuclear estrogen receptor binding [GO:0030331]; nuclear receptor coactivator activity [GO:0030374] ESRQMVTDLE;GGKMPVEPENQRTL;LSNTLVELSAQV 3 5.2 0.99714 -0.59264 10.4638 0 0 0 0 0 0 0 0 0 12.2166 0 12.0605 12.378 0 A0A8I3PCL9 A0A8I3PCL9_CANLF Uncharacterized protein PPIA Canis lupus familiaris (Dog) (Canis familiaris) PVKAGTFVTESLLSSTQ;VLVIKLLPV 2 18.7 0.98802 -0.22572 0 0 0 0 0 0 0 0 0 9.91489 0 0 9.98826 0 0 A0A8I3PCM1 A0A8I3PCM1_CANLF Galanin receptor 2 GALR2 Canis lupus familiaris (Dog) (Canis familiaris) galanin-activated signaling pathway [GO:0090663]; neuron projection development [GO:0031175]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944] cilium [GO:0005929]; membrane [GO:0016020] galanin receptor activity [GO:0004966]; peptide hormone binding [GO:0017046] RAMDLCTFVFSYLLPM;YASSFTLAAVSLD 2 7.5 0.99339 -0.16079 0 0 0 0 0 0 9.56125 0 0 0 8.81951 0 0 0 0 A0A8I3PCN5 A0A8I3PCN5_CANLF POZ/BTB and AT hook containing zinc finger 1 PATZ1 Canis lupus familiaris (Dog) (Canis familiaris) male gonad development [GO:0008584]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of DNA-templated transcription [GO:0045893]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217] male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin protein ligase binding [GO:0031625]" LSDASDLKTPEKQ;NFCSICNRGFSSASY;YHVRSHDGSVGKP 3 6 0.98774 -0.48032 0 0 0 0 0 0 10.6516 0 0 0 0 0 0 5.62246 0 A0A8I3PCP6 A0A8I3PCP6_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASLQNVLCPGP;TYNKWWCQGAEWKSCH;WNNADTYWCGIERSGTDLG 3 34.1 0.98514 0.035491 0 0 0 6.76341 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PCP8 A0A8I3PCP8_CANLF OTU deubiquitinase 7A OTUD7A Canis lupus familiaris (Dog) (Canis familiaris) EGCPNWESKKKQK 1 9 0.9913 -0.27278 0 0 0 0 0 0 0 7.33637 0 0 0 0 0 0 0 A0A8I3PCQ0 A0A8I3PCQ0_CANLF Ras-related protein Rab-8B RAB8B Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; Golgi vesicle fusion to target membrane [GO:0048210]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904] endosome [GO:0005768]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; trans-Golgi network transport vesicle [GO:0030140] GTP binding [GO:0005525]; GTPase activity [GO:0003924] NWIRNIEEHASSDVE 1 7.2 0.95051 0.056437 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7777 A0A8I3PCQ5 A0A8I3PCQ5_CANLF POZ/BTB and AT hook containing zinc finger 1 PATZ1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LVMKIRCPARCVGSTCGQR;YHVRSHDGSVGKP 2 6.2 0.95005 0.049902 0 0 0 8.0648 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PCR0 A0A8I3PCR0_CANLF Olfactory receptor OR52H7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NPIIYGVKTKQ;PLRYTNILTRQIITKIVV 2 9.2 0.97231 0.048313 0 0 0 0 0 0 0 0 8.42652 0 0 0 0 0 0 A0A8I3PCR3 A0A8I3PCR3_CANLF SIN3 transcription regulator family member A SIN3A Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; cellular response to glucose stimulus [GO:0071333]; cerebral cortex neuron differentiation [GO:0021895]; DNA replication [GO:0006260]; hematopoietic progenitor cell differentiation [GO:0002244]; heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; protein localization [GO:0008104]; regulation of axon extension [GO:0030516]; response to methylglyoxal [GO:0051595]; type I interferon-mediated signaling pathway [GO:0060337] kinetochore [GO:0000776]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053] chromatin binding [GO:0003682]; DNA binding [GO:0003677]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416] CTTTCDTETLHFVSINKYRVKYGTV;DKAADIIDGLRKNP;EAYENFLRC;EQLMSDENCFK;EQNEKYYLKSLDHQGINFKQ;GPTIAAVH;VIHRKALQRIYADKAA 7 7.8 0.98726 -0.37912 0 0 9.12926 0 11.5229 0 0 9.7708 0 0 0 9.79615 0 9.05631 7.64364 A0A8I3PCR6 A0A8I3PCR6_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EIGFDSCMAQMF;VVIHGFCMVF 2 7.4 0.98562 -0.44961 0 0 0 0 9.53644 0 0 0 9.78161 0 0 0 0 0 0 A0A8I3PCS1 A0A8I3PCS1_CANLF Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) CARM1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634] protein-arginine N-methyltransferase activity [GO:0016274] ERMLESYLHAKKYLRPG;QFYGYLSQQQNMMQDY 2 5.6 0.99008 -0.20489 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.33383 A0A8I3PCS4 A0A8I3PCS4_CANLF N-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase) Canis lupus familiaris (Dog) (Canis familiaris) N-acetylglucosamine kinase activity [GO:0045127] INPDGSESGCGGWGHMMG;LFIPGLDP;QDGGIVLISGTGSNCRLI;SGCGGWGHMMGDE 4 16 1.0042 -1.1044 0 0 0 5.17728 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PCT0 A0A8I3PCT0_CANLF PWWP domain containing 3B LOC119868546 Canis lupus familiaris (Dog) (Canis familiaris) GGILPSPP;ILLRRLRKRRNLKPRL;ILLRRLRKRRNLKPRLV;KGILLRRLRKRRNLKPR;KGILLRRLRKRRNLKPRL;KRSLKDYRKAKGILLRRLRKRRNLK;LLRRLRKRRNLKPRLV;RKAKGILLRRL;RLRKRRNLKPRLV;RRAKSSPSS;VLSRSGVSPKNK 11 8.6 1.0021 -1.8818 6.84499 5.21587 6.43679 4.80844 0 5.30539 0 0 9.21104 12.1873 0 0 8.5477 0 0 A0A8I3PCT1 A0A8I3PCT1_CANLF SEL1L2 adaptor subunit of ERAD E3 ligase Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] endoplasmic reticulum membrane [GO:0005789] AFIGKMYLEG;DLFVIGLIIVVLIFL;GVPSLNHSEIWINW;IVVLIFLLRNRYG;LPFKDIHLARRL 5 13.8 0.98386 -0.25538 0 0 9.85767 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PCT7 A0A8I3PCT7_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SETVLSPTELQNLD;VLNEKNMQPRILS 2 9 0.94033 0.059756 0 0 0 0 0 7.14629 0 0 0 0 0 0 0 0 0 A0A8I3PCU1 A0A8I3PCU1_CANLF Tubulin gamma complex associated protein 3 TUBGCP3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule nucleation [GO:0007020] centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; polar microtubule [GO:0005827] gamma-tubulin binding [GO:0043015] ADAALFSELH;AEMLLETVFT;FEVLECSWDELWNKVQ;ILGRSEADVAQQFQYAVR;LGQGDFIRH;LVWTYDPKIRLKTL;VHFIHQMQYYITFEVLECSW;WTYDPKIRLK;YLLDVLNRKY;YQHNLTGILE;YYITFEVLECSWDE 11 11.9 0.99736 -3.5635 10.4984 0 0 0 0 8.45273 0 9.0765 8.72554 0 8.916 8.86892 8.11702 7.84869 11.6027 A0A8I3PCU2 A0A8I3PCU2_CANLF Kininogen 1 KNG1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of blood coagulation [GO:0030195]; positive regulation of cytosolic calcium ion concentration [GO:0007204] blood microparticle [GO:0072562] cysteine-type endopeptidase inhibitor activity [GO:0004869] AEPEPAPESEVS;AGAEPEPAPESEVS;ASPELEPV;EAGAEPEPAPESEVS;EPEPAPESEVS;ESLSEEIDCNDE;GAEPEPAPESEVS;GFSPFRSSFMEKTEK;GRPQEAGAEPEPAPESEVS;GTTRRLRLCEY;KGRPQEAGAEPEPAPESEVS;PEPAPESEVS;PQEAGAEPEPAPESEVS;RPPGFSPF;RPPGFSPFRSSF;RPQEAGAEPEPAPESEVS;TFYSFKYQI 17 19.8 0 23.389 12.9746 13.1182 13.242 13.4467 13.9133 13.5017 14.2212 14.1442 14.1283 14.314 13.721 13.7846 13.2554 13.089 13.1158 A0A8I3PCU9 A0A8I3PCU9_CANLF Zinc finger CCHC-type containing 9 ZCCHC9 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; nucleoplasm [GO:0005654] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GEMIATDS 1 3 0.99002 -0.26349 0 0 0 0 0 0 0 0 10.6304 0 0 0 0 0 0 A0A8I3PCV4 A0A8I3PCV4_CANLF Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) PPP1R42 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] DIRDLEILENLNQLIAVDNQL;NFSDKNIDAIEDLSPCKNLT 2 18 0.93297 0.099282 0 0 0 0 0 0 0 0 0 0 0 0 6.72833 0 0 A0A8I3PCW2 A0A8I3PCW2_CANLF Small integral membrane protein 43 SMIM43 Canis lupus familiaris (Dog) (Canis familiaris) mesendoderm development [GO:0048382]; positive regulation of glucose transmembrane transport [GO:0010828] plasma membrane [GO:0005886] transmembrane transporter binding [GO:0044325] LALFFFLLFLLFLLLFVVI;LFFFLLFLLFLLLFV;LFLLFLLLFVVIKQL 3 34.9 0.9922 -0.14423 0 0 0 8.32656 3.79971 0 0 0 0 0 8.2605 0 0 0 0 A0A8I3PCW4 A0A8I3PCW4_CANLF Beta-transducin repeat containing E3 ubiquitin protein ligase BTRC Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] DEFQIVSSSHDDTIL;LIHHCEAVLH;NTLIHHCEAVL;TKLANGTS 4 6.4 1.0022 -0.98864 9.90632 0 0 0 0 0 0 0 0 0 0 0 0 7.22342 0 A0A8I3PCY5 A0A8I3PCY5_CANLF ATE1 opposite strand ATE1OS Canis lupus familiaris (Dog) (Canis familiaris) KKIKSLGG 1 2.1 1.0033 -1.1044 0 0 0 0 0 0 0 9.15289 0 0 0 0 0 0 0 A0A8I3PCY6 A0A8I3PCY6_CANLF "Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1)" ADSS1 ADSSL1 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' AMP biosynthetic process [GO:0044208] cytoplasm [GO:0005737] adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287] IDFGTYPFVTSS;IGPAYSSKA;NNAGHTVVVDGREYDFHL;PYFPANQE;VGVSYKLNGKR 5 12.7 1.0033 -1.0345 10.5834 0 0 0 0 10.0673 0 0 0 5.47641 0 0 0 9.53019 0 A0A8I3PCY9 A0A8I3PCY9_CANLF YTH domain-containing family protein LOC119865722 Canis lupus familiaris (Dog) (Canis familiaris) mRNA destabilization [GO:0061157] cytoplasm [GO:0005737] mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247] FIIKSYSEDDIHRSI;GVLSGNGGTNVNMPV;VPKAPAPQQA 3 7.9 0.9878 -0.5047 0 0 0 0 0 0 0 9.82456 8.82279 9.00487 0 0 11.6199 9.40472 0 A0A8I3PCZ5 A0A8I3PCZ5_CANLF TBC1 domain family member 12 TBC1D12 Canis lupus familiaris (Dog) (Canis familiaris) LWWQGLPPSVRGKVWSL;QDGKMIRATGGFGGGVG;SRNTFEVSRDHLPP;VGNELNITPELY 4 7.8 0.9865 -0.39293 0 0 0 0 0 6.80168 0 0 0 0 7.71108 0 0 9.78885 0 A0A8I3PCZ7 A0A8I3PCZ7_CANLF P-type Cu(+) transporter (EC 7.2.2.8) ATP7A Canis lupus familiaris (Dog) (Canis familiaris) copper ion transmembrane transport [GO:0035434] membrane [GO:0016020]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; copper ion binding [GO:0005507] GFDAALSGIYSVLV;GVYHIKVSLE;LEVVLMTGDNSRTARS;LVLQPWMGS;VGIPIAAGV 5 4.1 1.0026 -0.76068 0 0 0 9.09054 0 0 0 0 10.3 0 5.31738 0 0 0 0 A0A8I3PD00 A0A8I3PD00_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) PPIL4 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723] AACCGGGA 1 1.5 0.99057 -0.26592 0 0 0 0 0 0 0 0 0 0 0 7.92481 0 0 0 A0A8I3PD01 A0A8I3PD01_CANLF Uncharacterized protein CCDC163 Canis lupus familiaris (Dog) (Canis familiaris) AEGQQAQAHSWKVGRGSDLSL;GGQAQQSRVETPF;WKVGRGSDLSL 3 10.3 0.93829 0.071348 0 0 0 0 0 0 0 0 0 7.20955 0 0 9.13835 0 0 A0A8I3PD03 A0A8I3PD03_CANLF Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K11 Canis lupus familiaris (Dog) (Canis familiaris) cell cycle G1/S phase transition [GO:0044843]; JNK cascade [GO:0007254]; microtubule-based process [GO:0007017]; positive regulation of JNK cascade [GO:0046330] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein homodimerization activity [GO:0042803] DLQPPGGP;EKELLSREEE;LFDELRAKEKE;RDLQPPGG;TFPRFRAIQ;VLLWELLTGEV;WGPSSPKPGEAQ 7 6.9 1.0035 -2.2355 8.87498 0 0 0 0 0 0 9.04136 7.19131 0 8.7151 0 0 0 0 A0A8I3PD05 A0A8I3PD05_CANLF BTB/POZ domain-containing protein 16 BTBD16 Canis lupus familiaris (Dog) (Canis familiaris) AQLCGSVQ;FNQEYTTH;ILQFSSLFQRC;MSFLFFPSSL;RLHGIIKG;SLPPHLFF;VGRQIHLRKIPQELLHRVLRSPRL 7 14 0.99709 -4.0306 4.86567 0 0 0 0 0 9.91081 10.6188 4.69655 0 0 0 0 0 3.25706 A0A8I3PD06 A0A8I3PD06_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PVETTAVMHQPTL 1 13.7 0.98425 -0.24484 0 0 0 0 0 0 0 0 0 0 0 0 0 15.6811 0 A0A8I3PD12 A0A8I3PD12_CANLF Cytokine-inducible SH2-containing protein CISH Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein ubiquitination [GO:0016567] plasma membrane [GO:0005886] PFVRRSSARSL;SGWYWGSITASEARQHLQKMPEGTF 2 14 0.98951 -0.21788 0 0 12.0336 0 0 0 0 9.49522 0 0 0 0 0 0 0 A0A8I3PD26 A0A8I3PD26_CANLF ATP synthase c subunit lysine N-methyltransferase ATPSCKMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] mitochondrial membrane [GO:0031966] protein-lysine N-methyltransferase activity [GO:0016279] LWKMLRLKEKLALEL;YSRYRAWREGVQDSAKF 2 15 0.93925 0.1001 0 8.2281 0 0 0 0 0 0 0 0 0 0 0 7.88277 0 A0A8I3PD31 A0A8I3PD31_CANLF Kinetochore associated 1 KNTC1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly checkpoint signaling [GO:0007094] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; kinetochore microtubule [GO:0005828]; plasma membrane [GO:0005886]; RZZ complex [GO:1990423]; spindle pole [GO:0000922] AKHVFEKKLKPQLLK;DIQKDNLQKKDEC;ELVYKVKS;ELVYKVKSNDILERL;FCELSTDAR;FITEYSKHRG;GQKILAKWLEQAARNLEL;IPSVLEKFV;MKAYEVTQSKHKSW;QAATICSPDFLLDAL;SLYQEIEMELKFCELST;TSLPYCSINEGDN;VDLEYQYMLEHVISL 13 7.1 1.0028 -0.79858 0 0 8.18075 0 10.487 9.66832 0 0 9.39461 8.27612 8.54624 10.8691 8.52642 9.94844 8.93165 A0A8I3PD42 A0A8I3PD42_CANLF INO80 complex subunit D INO80D Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] Ino80 complex [GO:0031011] CTQKHQLD;FGHQLGSHSGIPKDLQ;KKKRRRGPRRPQKPIPP;SRQQYSSDHSHSSPHG;SVSLPVEAAQIRSPS;VAKYNSQR;VCKSPPPPNTSLPMQG 7 9.3 1.003 -2.4615 10.5082 10.2657 0 6.74295 0 9.65388 0 0 0 8.26045 0 0 6.09843 0 0 A0A8I3PD46 A0A8I3PD46_CANLF Chromosome 14 open reading frame 180 C8H14orf180 Canis lupus familiaris (Dog) (Canis familiaris) LEDLRARLLVLALRLRHTALS 1 13.3 0.97683 0.047914 0 8.11171 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PD57 A0A8I3PD57_CANLF Zinc finger protein 169 ZNF169 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] DEPWREENECFLDLCPGE 1 15.1 0.98456 -0.25716 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.7312 A0A8I3PD69 A0A8I3PD69_CANLF 4'-phosphopantetheine phosphatase (EC 3.1.3.-) PANK4 Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] cytoplasm [GO:0005737] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] AEKFRQKYWSKLQTLRHQPF;DEIFRNLENAKRFAID;EVTARLHFVKFE;LDRVYFGGFFIRG;TITYSINFFSKGEVQ 5 10.1 0.69611 0.28707 0 7.05409 7.2213 0 6.89045 0 9.99449 0 0 0 0 0 6.90038 5.21502 0 A0A8I3PD76 A0A8I3PD76_CANLF Zinc finger protein 512B SAMD10 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AGAVRAGFGERRDVDAT;EDKSRMHRAKKPEG;KHRIWNHMDRPVP;KKVLAPAS;LSLMNQWKDE;PGLPTLNP 6 6.6 0.99942 -2.8696 0 0 0 9.00124 0 7.92267 8.42748 0 0 0 0 10.7768 7.89615 0 0 A0A8I3PD87 A0A8I3PD87_CANLF Nuclear receptor coactivator 5 NCOA5 Canis lupus familiaris (Dog) (Canis familiaris) glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of insulin receptor signaling pathway [GO:0046627] actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] DLRDFRDLRDSRDFRDHRDP;IVVNKQTKDY;QAGSARNMGPRPGA;TGINFDNPSVQKALDTLIQS 4 11.1 1.0016 -0.74763 0 0 0 0 0 0 0 12.042 6.63706 0 0 0 0 0 0 A0A8I3PDA9 A0A8I3PDA9_CANLF Mitochondrial import inner membrane translocase subunit TIMM9 Canis lupus familiaris (Dog) (Canis familiaris) protein insertion into mitochondrial inner membrane [GO:0045039] mitochondrial intermembrane space protein transporter complex [GO:0042719]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721] membrane insertase activity [GO:0032977]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087] KLTETCFLDCVKDFTTREVKP 1 23.6 0.98486 -0.24692 0 0 0 0 0 9.9479 0 0 0 0 0 0 0 0 0 A0A8I3PDB9 A0A8I3PDB9_CANLF Contactin associated protein family member 4 CNTNAP4 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; membrane [GO:0016020] calcium ion binding [GO:0005509] FGYLDLDHEGNV;GAVLKLLLLL;GLIAVVIFILLCIAAIAIRI;SGGTYYFGGCPDNSFGSK;TYWGGSLPDPQKCTCGLE;VTPGVEPGCRGHCSS 6 7.4 0.99405 -0.17378 0 0 0 0 0 0 5.78293 11.1438 10.5793 0 0 0 0 0 0 A0A8I3PDC6 A0A8I3PDC6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GASILPFYLIRLELVK;SPAASLIT;VGSRNSAS 3 9 1.0022 -1.282 11.9037 0 0 0 0 0 0 0 0 0 0 0 0 7.6811 6.66917 A0A8I3PDC9 A0A8I3PDC9_CANLF "Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive)" SLC2A4 Canis lupus familiaris (Dog) (Canis familiaris) amylopectin biosynthetic process [GO:0010021]; brown fat cell differentiation [GO:0050873]; cellular response to osmotic stress [GO:0071470]; cellular response to tumor necrosis factor [GO:0071356]; glucose homeostasis [GO:0042593]; glucose import in response to insulin stimulus [GO:0044381] cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; sarcolemma [GO:0042383]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140] glucose transmembrane transporter activity [GO:0005355] EKQAPCTGSPTWDLIPDL;RFLIGAYSGLTSGL;WQPGRKSSVQSQKQ 3 8.8 0.99474 -0.12798 0 0 7.38422 0 0 0 10.2524 0 0 0 0 0 0 9.15246 0 A0A8I3PDD6 A0A8I3PDD6_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRR Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] PALCLLLRLHAA;YSGKEKAF 2 3.1 0.94653 0.05044 7.36484 0 0 0 0 0 8.76603 0 0 0 0 0 0 0 0 A0A8I3PDE2 A0A8I3PDE2_CANLF GC-rich promoter binding protein 1 like 1 GPBP1L1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] CRPIGTPSGVWEN;TEDELREFH;TTPPIEIS 3 6.3 0.98545 -0.44842 0 0 0 0 0 0 0 0 0 11.1164 7.95693 0 0 0 0 A0A8I3PDE4 A0A8I3PDE4_CANLF Euchromatic histone lysine methyltransferase 1 EHMT1 Canis lupus familiaris (Dog) (Canis familiaris) facultative heterochromatin formation [GO:0140718]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995] chromosome [GO:0005694]; nuclear body [GO:0016604] C2H2 zinc finger domain binding [GO:0070742]; histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; p53 binding [GO:0002039]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270] DDCSSSNCMCGQ;DLEQRSKAE;EEDESEELDEDE;GRLLPEFNMAEPP;IDDCSSSNCMC;KPARKRRRRNKKKQ;KRRRRNKKKQ;NICLHWAAFS;QDGQENGLP;QESAGTGEEDEDGDESDLSSES;SIKKKFLKRKGK;SLVPKKKTKVL;TYSLVPKKKT 13 9.7 1.003 -2.2673 0 5.34167 0 0 6.41856 5.41849 0 3.59717 10.4177 9.87827 0 0 6.74967 0 4.60567 A0A8I3PDF3 A0A8I3PDF3_CANLF MLX interacting protein MLXIP Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" FDTVNKQTCQ;LMSEFSDTLFST 2 2.4 0.98759 -0.40126 0 8.93911 0 14.3859 0 0 0 0 0 0 0 0 0 0 14.6817 A0A8I3PDG4 A0A8I3PDG4_CANLF Uncharacterized protein SMKR1 Canis lupus familiaris (Dog) (Canis familiaris) SPAAMLNLYYIAHNVAD 1 25.8 0.97626 0.046227 6.50394 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDH2 A0A8I3PDH2_CANLF Fibronectin leucine rich transmembrane protein 3 FLRT3 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560] axonal growth cone [GO:0044295]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; postsynaptic membrane [GO:0045211] chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein homodimerization activity [GO:0042803] ELRLDDNRIS;FLQVAPLSV;PVNLPGTN 3 4.2 0.99028 -0.53591 0 0 0 0 0 10.4682 0 0 0 0 0 0 0 0 10.6475 A0A8I3PDH8 A0A8I3PDH8_CANLF Centrosome and spindle pole associated protein 1 CSPP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cytokinesis [GO:0032467] centrosome [GO:0005813]; microtubule [GO:0005874]; spindle pole [GO:0000922] DDMKHMGDDGSDSAAAEPWL;DLDAIPSAKVRDHRMSREDSDDFLK;DYERKKHKLKEELRQDYRRYLT;EVSEEMDERFRYESDF;FSVAPRHFEEMIPP;GKGGGGAP;KYRLELLEQMA;MYGNRRGNVPPKDYGG;PLSAPSAPPIPSI;SLQSYQEALQQ;STEKNQRNKKPICQG;VSLDQNLATSNAENLEDSTNKN 12 16.9 1.0027 -1.1825 13.392 9.75607 9.8824 6.18822 6.03716 0 0 8.8099 0 0 8.37639 0 8.03227 0 11.9276 A0A8I3PDJ0 A0A8I3PDJ0_CANLF F-actin-capping protein subunit alpha CAPZA3 Canis lupus familiaris (Dog) (Canis familiaris) barbed-end actin filament capping [GO:0051016] cortical cytoskeleton [GO:0030863]; F-actin capping protein complex [GO:0008290]; membrane [GO:0016020] actin binding [GO:0003779] VLSRKEKERVIRRLLIQ;VTGRIFVQAHFFRAVNL 2 11.4 0.93436 0.093287 0 0 6.62477 0 8.59261 0 0 0 0 0 0 0 0 0 0 A0A8I3PDJ5 A0A8I3PDJ5_CANLF Fetuin B FETUB Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869]; metalloendopeptidase inhibitor activity [GO:0008191] AQENSPVEAFPVKLDLTTD;ATSVPMPVLPLPVL;ATSVPMPVLPLPVLSRD;LDVLETDCHVL;NSPVEAFPVKLDLTTD;PAQQGNLLILPP;PGPAQQGNLLILPP;PRVLEAAL;PVKLDLTTD;SPVEAFPVKLDLTTD;SVPMPVLPLPVL;TSVPMPVLPL;TSVPMPVLPLPVL;TSVPMPVLPLPVLS;TSVPMPVLPLPVLSR;TSVPMPVLPLPVLSRD;VGEFQQKNTAPTNS;YFVEYLIKESPCTKSQVS 18 26.2 0 24.764 13.7638 14.0531 13.5354 11.6448 11.6488 12.2368 14.3073 14.635 14.2257 12.9399 12.9796 14.0601 13.0891 12.463 13.3934 A0A8I3PDK2 A0A8I3PDK2_CANLF Olfactory receptor OR51B9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGVFMRGFVL 1 3.2 0.98983 -0.26397 0 0 0 0 0 0 0 0 10.3261 0 0 0 0 0 0 A0A8I3PDL1 A0A8I3PDL1_CANLF Glucocorticoid receptor (Nuclear receptor subfamily 3 group C member 1) NR3C1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] centrosome [GO:0005813]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; spindle [GO:0005819] nuclear glucocorticoid receptor activity [GO:0004883]; sequence-specific DNA binding [GO:0043565]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270] PCMYDQCKHML;PSKEEISSSVLGRERGNVMDFYKT 2 4.8 0.99714 -0.58814 0 0 10.5974 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDL3 A0A8I3PDL3_CANLF Uncharacterized protein LOC119869194 Canis lupus familiaris (Dog) (Canis familiaris) AMFVESFIYKHPQEAKYVFVEPLEW;CDRQGDRSVHSEH;EIAMFVESFIYKHPQEAK;EMNMECDRQGDR;PIQDSFQKPLD;REPEMNMECDRQGD;TTQNEDSDSNDPGLSIME;VFLNGGKTEDEGEI 8 8.5 1.0043 -1.0871 0 0 0 0 0 0 4.7016 7.34855 0 0 0 0 10.4188 0 0 A0A8I3PDL5 A0A8I3PDL5_CANLF Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) VPS72 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of cell cycle [GO:0051726]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815] NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleosome [GO:0000786] ATP-dependent H2AZ histone chaperone activity [GO:0140849]; histone binding [GO:0042393] DTEDEVDSDFDIDEGD;EVCPVTHRPALYRDPVTDIP;FYQTTYGGFTEESGDDEYQ;LEAEEEDEFYQ;YQGDQSDT 5 18.4 1.0023 -0.96994 0 0 13.4449 0 0 0 0 0 0 0 0 0 9.59203 0 0 A0A8I3PDL8 A0A8I3PDL8_CANLF SRY-box transcription factor 18 SOX18 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell maturation [GO:0048469]; embryonic heart tube development [GO:0035050]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; establishment of endothelial barrier [GO:0061028]; hair follicle development [GO:0001942]; in utero embryonic development [GO:0001701]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of stem cell proliferation [GO:0072091]; stem cell fate specification [GO:0048866]; vasculogenesis [GO:0001570] chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EKRPFVDEAERLRVQHLRDHPNYKY;LEPGEAAFFPAPE;NYKYRPRRKKQARKARRL;PEDCALRAFRAPYGPAE;RPRRKKQARKARRLEPGLLL;SPAGRGERPAADE;WAPGPAAAA 7 26 0.68182 0.30195 0 0 0 0 6.91085 0 4.95317 0 5.31227 0 0 0 7.77123 7.16269 11.6557 A0A8I3PDL9 A0A8I3PDL9_CANLF Transmembrane protein with EGF like and two follistatin like domains 2 TMEFF2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TSTCDICQFGAECDEDAEDVWCV;VSEGSCATDAGSGSGDGV 2 11.8 0.92862 0.094566 9.88865 0 0 0 0 0 0 0 0 6.71287 0 0 0 6.87725 0 A0A8I3PDM2 A0A8I3PDM2_CANLF Ring-box 1 RBX1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SIKLNCSVIHLMT 1 16.7 0.93502 0.065297 8.75662 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDN3 A0A8I3PDN3_CANLF 40S ribosomal protein S7 RPS7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural crest cell differentiation [GO:0014033]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] centrosome [GO:0005813]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; synapse [GO:0045202] mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein kinase binding [GO:0019901]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948] RTPFPLEGRSGFAVWAESEFSAFV 1 11.2 0.9741 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 8.5972 0 A0A8I3PDQ6 A0A8I3PDQ6_CANLF Transmembrane emp24 domain-containing protein 1 (p24 family protein gamma-1) TMED1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] DEEVEGWAEAVEPEEM;GAGLDVDFTLESPQ 2 13.2 0.91621 0.11878 0 0 0 0 0 0 0 0 8.68839 0 0 4.73211 0 0 0 A0A8I3PDR0 A0A8I3PDR0_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) ATXN3 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] TSEDYRTFLQ;YKEHWFTVRKLGKQ 2 8 0.99211 -0.55054 0 8.89863 0 0 0 0 0 0 0 0 0 6.57454 0 0 0 A0A8I3PDR4 A0A8I3PDR4_CANLF T cell receptor beta variable 25-1 TRBV25-1 Canis lupus familiaris (Dog) (Canis familiaris) GVNTTEKAELSSGSTV 1 13.1 0.96186 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 8.60984 0 A0A8I3PDR9 A0A8I3PDR9_CANLF Tetraspanin TSPAN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILLLVFVTEVVVV;LIFWFVIILLLVFV 2 10.6 0.93706 0.060769 0 0 0 0 4.46159 0 0 0 0 0 0 0 0 0 0 A0A8I3PDS4 A0A8I3PDS4_CANLF Splicing factor 3a subunit 1 SF3A1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; U2-type prespliceosome assembly [GO:1903241]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004] RNA binding [GO:0003723] AAIPKVMQQQQQAT;DTQVQDMDEGSDDEE;DTQVQDMDEGSDDEEE;EEGQKVPPPPETPMPPPLPPTPD;MQKEQRNYQFDFLRPQ;PPPEFEFIAD;VCYRVEWAKFQ;VSVIKVKIHE;WAKFQERERKKEEE 9 13.5 1.0019 -1.3024 0 8.76132 9.57242 9.3735 8.77245 0 0 0 0 0 0 7.75429 4.44347 0 5.79753 A0A8I3PDS7 A0A8I3PDS7_CANLF Uncharacterized protein LOC609833 Canis lupus familiaris (Dog) (Canis familiaris) AQVGDEAVQ;VLLVARCFSGNVLFNSPEFVD 2 7 0.92388 0.095426 0 0 0 0 0 10.0251 0 0 0 0 0 0 0 0 0 A0A8I3PDS9 A0A8I3PDS9_CANLF TNF superfamily member 13 TNFSF13 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576]; membrane [GO:0016020] tumor necrosis factor receptor binding [GO:0005164] AALGAVAC;LGAVACAMALLTQQTELQN 2 9.4 0.99444 -0.059849 0 11.3044 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDU0 A0A8I3PDU0_CANLF "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" RABL3 Canis lupus familiaris (Dog) (Canis familiaris) L-phenylalanine catabolic process [GO:0006559]; tyrosine metabolic process [GO:0006570] "homogentisate 1,2-dioxygenase activity [GO:0004411]; metal ion binding [GO:0046872]" RSWLYRILPSVCHKPFESIDQG;SSSCLDENYYK;TVLTAKSVRPGVA 3 10.4 0.99158 -0.18335 0 10.8881 7.75295 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDU1 A0A8I3PDU1_CANLF "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta)" ACAP1 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] CELGNVVINQIYEARVE;DGNAQCCDCRE;DGNAQCCDCREPAPEWASI;DPGGAGHV;DSEDKDPLTI;GAGHVAAQ;LDIFRDFSLMAS;QSVDGNAQCCDCRE;QVQSVDGNAQCCDC 9 9.9 1 -2.8413 4.63488 8.38982 0 6.92588 9.44186 0 10.124 8.62589 0 0 0 9.57469 0 0 0 A0A8I3PDU8 A0A8I3PDU8_CANLF Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (EC 1.14.18.2) (CMP-N-acetylneuraminate monooxygenase) (CMP-Neu5Ac hydroxylase) (CMP-NeuAc hydroxylase) CMAH Canis lupus familiaris (Dog) (Canis familiaris) N-acetylneuraminate metabolic process [GO:0006054] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" DKYIKETNIK 1 1.8 0.99847 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 5.74607 0 A0A8I3PDV2 A0A8I3PDV2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MRALITSLWLQVNYELRV 1 11.3 0.98071 0.048313 0 0 0 0 0 11.1425 0 0 0 10.5607 0 0 0 0 0 A0A8I3PDV4 A0A8I3PDV4_CANLF Fragile X messenger ribonucleoprotein 1 FMR1 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of translation [GO:0017148]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of filopodium assembly [GO:0051489]; regulation of mRNA stability [GO:0043488]" cytoplasmic ribonucleoprotein granule [GO:0036464]; dendritic filopodium [GO:1902737]; dendritic spine neck [GO:0044326]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; presynapse [GO:0098793] mRNA 3'-UTR binding [GO:0003730]; protein homodimerization activity [GO:0042803]; translation regulator activity [GO:0045182] PGVTAIDLD;VRVRIEAENEKS 2 3.9 0.99009 -0.20098 0 0 0 0 7.13607 9.71089 0 0 0 0 0 0 0 0 0 A0A8I3PDW2 A0A8I3PDW2_CANLF ADP-ribosylation factor ARF3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] IVTTIPTIVEY 1 6.3 0.98618 -0.24596 9.66463 0 0 0 0 0 10.3028 0 10.4378 0 0 0 0 10.4864 0 A0A8I3PDW3 A0A8I3PDW3_CANLF Chondroitin sulfate proteoglycan 4 CSPG4 Canis lupus familiaris (Dog) (Canis familiaris) glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; substrate-dependent cell migration [GO:0006929] nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726] coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901] CVPEPGLPPV;EHTQKPLGPEVFQAYDP;GVRLHRPVLPARPLRRPGPRAGRQR;LQTPAETPLSDSAV;LSAEHLFVKSLN;LTMWEGATVPFPPEALRGADS;RYLSTDPQHRTEDAVERVALEVQVG;TLAPEAWSAVELP 8 5.7 0.97362 0.035538 0 0 0 5.28199 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDX2 A0A8I3PDX2_CANLF U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) SNRPC Canis lupus familiaris (Dog) (Canis familiaris) mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; U1 snRNA binding [GO:0030619]; zinc ion binding [GO:0008270] PMGGHMPMMPGPPMMRPPA;PPAEAMIPPPPSLPGPP 2 22.8 0.99233 -0.1844 0 0 0 0 0 0 8.75619 0 0 0 0 0 0 0 12.3844 A0A8I3PDY3 A0A8I3PDY3_CANLF Calcitonin CRSP-3 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of cytosolic calcium ion concentration [GO:0051480] extracellular space [GO:0005615] calcitonin receptor binding [GO:0031716]; hormone activity [GO:0005179] EAKRCSNLSTCVL;GVGAPGKK;VGAPGKKR 3 16.7 1.0027 -2.5198 0 0 0 0 0 0 0 0 0 4.09441 0 0 10.4425 0 0 A0A8I3PDY8 A0A8I3PDY8_CANLF GID complex subunit 8 homolog GID8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cell junction [GO:0030054]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151] protein homodimerization activity [GO:0042803] HVQRADMNRLIMNYLVTEGFKEAAE;LAKLLKLLL;NRYLYFHLQ;PFGDLLHMM 4 22.8 1.0027 -1.4057 0 7.02658 0 3.27522 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PDZ4 A0A8I3PDZ4_CANLF Solute carrier family 15 member 1 SLC15A1 Canis lupus familiaris (Dog) (Canis familiaris) dipeptide import across plasma membrane [GO:0140206]; peptide transport [GO:0015833]; protein transport [GO:0015031] membrane [GO:0016020] dipeptide transmembrane transporter activity [GO:0071916]; symporter activity [GO:0015293] AQFDDDEKKNLE;EQGHRHTL;LLILYFRRFIGWDDNLS 3 5.6 1.0027 -1.5852 0 11.0965 0 0 0 0 0 0 0 0 0 8.70791 0 0 0 A0A8I3PDZ5 A0A8I3PDZ5_CANLF SECIS binding protein 2 like SECISBP2L Canis lupus familiaris (Dog) (Canis familiaris) selenocysteine insertion sequence binding [GO:0035368] DETIQQKLSSKVLDDL;DTGLSMPS;EDDEDEEEEEDYTHE;EEEEDYTHEPISVEV;ELNENGNTKDE;EVEPFIPQKKNPDT;KHMKLNKIKCVIISPNCEKI;VEPTPIPS 8 9.1 1.0037 -1.9685 10.4199 7.7385 0 0 6.56406 0 8.85496 0 0 0 0 0 0 7.18943 10.0088 A0A8I3PE00 A0A8I3PE00_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CPSCEDLITYGP;QDILEDLY 2 4.7 0.98896 -0.5224 0 0 0 0 0 0 0 8.35288 0 0 9.01987 0 0 0 0 A0A8I3PE10 A0A8I3PE10_CANLF Torsin TOR1B Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763] endoplasmic reticulum lumen [GO:0005788]; nuclear envelope [GO:0005635] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802] LEEKLFGQHLAT;YTDLFCRFAECCLEEQRL 2 8.9 0.98832 -0.26455 0 0 0 0 0 0 6.8268 0 0 0 0 0 0 0 0 A0A8I3PE12 A0A8I3PE12_CANLF "NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)" NOL7 SIRT5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of reactive oxygen species metabolic process [GO:2000378] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634] NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] NMADFRKLFAKAK;SYLAVRLKDQDLR;SYLAVRLKDQDLRD;WQAQDLATPQ 4 8.9 0.98705 -0.40817 0 0 0 0 0 12.6741 0 0 0 0 7.26153 0 0 11.1836 0 A0A8I3PE21 A0A8I3PE21_CANLF Olfactory receptor OR6C1L Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIIILSYIYILRTILKIP 1 5.8 0.97022 0.048313 3.85977 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PE36 A0A8I3PE36_CANLF Mpv17-like protein 2 MPV17L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] DPAPVCCLM;LMAAGDGV;TAGGWGAG 3 11.1 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 0 7.27398 0 0 0 A0A8I3PE51 A0A8I3PE51_CANLF Protocadherin 9 PCDH9 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ETPLDRNIGDSSQPY;KKHHVIQELPL;KKKKRKKRKSPK;LVRCRHASRFK;NSDPNSDGPLGPR;QESCSDSGLGDHEPV;SLPAELEEQSIGRFDW 7 7.7 0.99773 -0.60113 0 0 9.41371 0 0 8.08561 0 0 0 0 0 10.8425 9.49947 3.35769 16.5002 A0A8I3PE56 A0A8I3PE56_CANLF Pleckstrin homology domain containing A6 PLEKHA6 Canis lupus familiaris (Dog) (Canis familiaris) EQLNLDVQNEVL;LSPFSLVSGSQGS;NRMVENSSPRAQI;NSVPKPEPEAKT;QGSPTKPGSSEEPGPPR;SLTPPANP 6 5.5 0.98815 -0.49096 0 10.4846 0 0 0 0 10.8473 9.39298 0 0 9.74255 8.71757 0 0 0 A0A8I3PE59 A0A8I3PE59_CANLF Paternally expressed 10 PEG10 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] DYSNAFQMIAQD;IDGRPIASG;LVPFMAQCQL;QPSFYYPV;VGGARMRLTQEEK 5 6.6 1.0035 -2.3828 14.8928 15.0444 14.988 14.0748 14.2552 14.1091 14.7653 14.7175 14.7919 14.9775 14.9163 0 15.0699 15.04 14.9579 A0A8I3PE62 A0A8I3PE62_CANLF Semaphorin 3F SEMA3F Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165]; system development [GO:0048731] semaphorin receptor binding [GO:0030215] CQAYGAACADCCLARD;HFFNFLLNTTDYRILLKDEDH;PGAGPPTPPY;QATVKWLFQRDPSDRRR 4 8.5 0.99327 -0.16261 7.02381 0 0 0 0 0 9.09879 0 9.3014 0 0 0 0 0 0 A0A8I3PE64 A0A8I3PE64_CANLF Legumain LGMN Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] HVIDTAVRKMVSLMASSDA;MVFYIEACESGSMM;PQNFLAVLRGDEEA;STGVVICGRFPNGWYNYRHQ 4 16.5 0.98766 -0.40004 0 0 0 0 11.4728 0 0 8.8539 0 0 0 0 7.98652 0 9.23175 A0A8I3PE72 A0A8I3PE72_CANLF Titin TTN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; organelle [GO:0043226] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AENDHGIAKAPCTV;AGEGGVGEAQEAEGSAVG;AGETFVLEADIRGKPIPDIV;AGTRSMAV;AKFECEVSREPKTFRW;AKIRNYYLEK;APLNDGCAPITHYIIE;APSESTGTVICKDEYEAPTIVL;ATSTATLYVEARHIE;CPEVKDKT;CSISKENFEVQW;DLRFRVTGLTEGHSYEF;DPTMVVEWL;DTMRLLERPPEFTL;DVDKTEVSLVWNKPD;EASVEVTWTHQGV;EDPKGPPSPPLD;EMREKDTDQWY;ENAAGPGK;EPLEVALGHLAK;EVSETDTIKLVCEVS;EVTEITEI;EYKIRVSA;FDVTEVTN;GEEEEWTVVSTKGE;GENKLSWTVKDLIPNGEYFF;GEPVQSEPVKMVD;GEVSLGWEEPLTDGGSKII;GKPQNPRV;GTDVVFLAEL;GVELTNSEE;GVRQLENSEKYEITYQ;IDNNGHYQ;IEKQHAVVEF;IEPDVRPAFSNYSVQ;IERVSTKVIRTLKHR;IPGQEYIFRVRAENRF;ITKNTADLKW;IVHRCVETSSKKT;KDCRLDDECEYACGVE;KFEGPCPPYFLKEFKPIHCARG;KNVAGTRSMAVNCKVLDKP;KRDLPEGRWMKA;KTLEEEVTVVKGQ;KVAEHPQRPAS;KVSEPPLPPGRVTLVDVTR;LDQAGEVLYQ;LEEGKEYQFRV;LEGNEYIFRI;LEILDCQAEDSGTY;LKGADVII;LLLPVLIK;LSWTKPDFDGGSV;LVAEQLQSTVTLEQNM;LVRPLHSVEVMETETARFETEIS;MVVVWERPASDGGSEI;NEGQNAVFSCEISGEPSPEIEW;NFEVQWKRDDKTL;NSVGIGPFTE;NWEEPEYDGGSP;PEPVKVPEIKPAIPLP;PEVQASDTLSKESLLSGIP;PLDNGGSPITGYWLEKR;PLYDGGSKIMGYIIEKI;PPENDGGV;PPIKLKIGLITKNTVHLSW;PPSGISRLIKCREPV;PSRFFRMTQFED;PVETIQRTTARD;PVVAEYPF;QEPESQVILSE;QFRVKAYNEKG;SIPGPPETLQIFDVSRDGMTLTWY;SLKGPAVE;SSITNAKE;SVQVGQDLKIEVPISGR;TATVSWKRP;TDGLRRILKIKKAELK;TDGRKRILII;TEMLEYPDYELDERYQEG;TFTVERLVENTEYEFR;TTKLGEAAQLSCQIVGRPLPD;TVKDQTCPPSI;VEEDQRIKQ;VEEVSCFH;VEKPGKIVPGVI;VGESLESTAVKALNP;VGQKTASIEVITLDKPDPPKGPV;VIAKAGEDVQVLIPFKGRPPPTVT;VIHEGLDYYAL;VNVCGRATAVVEVNVLDKPGP;VPDAPKAP;VQPIKEPSPN;VTSSYTML;VYYVSANAMSIRWEEP;WNPPLQDG;YESLMKSQ;YMCDCGTD;YNLTLENNSGSKTAFVNVRVLDSPS 100 5 0.99664 -23.868 12.9792 11.7327 11.6313 11.3544 9.8252 11.0839 14.0542 13.1956 13.6157 10.0447 10.1699 10.5231 12.233 12.9844 14.5938 A0A8I3PE86 A0A8I3PE86_CANLF Tropomodulin 4 TMOD4 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] striated muscle thin filament [GO:0005865] tropomyosin binding [GO:0005523] EEVNLNNIQDIP;VRFGYHFTQQGPRARAAQAMTRN 2 10.1 0.93358 0.096693 0 0 0 5.45427 0 0 0 0 0 0 9.2123 0 0 0 0 A0A8I3PE87 A0A8I3PE87_CANLF Large ribosomal subunit protein eL30 (60S ribosomal protein L30) Canis lupus familiaris (Dog) (Canis familiaris) cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KAKLVILADNCPA;NTELGTACGK;YKQTLKMIRHGKAKLVIL 3 29.6 0.99094 -0.21083 0 0 0 0 0 0 7.64652 0 13.2091 0 0 0 0 0 0 A0A8I3PEA3 A0A8I3PEA3_CANLF T-complex protein 1 subunit epsilon (CCT-epsilon) CCT5 Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein folding [GO:0061077]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein stabilization [GO:0050821]; response to virus [GO:0009615] cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; unfolded protein binding [GO:0051082] DVDHQIAKLMVELS;TKLIKGVIVDKDFSHPQMPKQVEN;TLAFDEYGRPFLI;VANTMRTSLGP 4 11.5 0.98645 -0.42425 6.91803 0 0 0 0 0 12.7064 6.8125 0 0 0 0 0 0 0 A0A8I3PEA6 A0A8I3PEA6_CANLF Chondroitin sulfate proteoglycan 4 CSPG4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGRAHFLQ;CVPEPGLPPV;EHTQKPLGPEVFQAYDP;IIPVCLVLLLLALLLPLLFYLRKRN;LQTPAETPLSDSAV;LSAEHLFVKSLN;LTMWEGATVPFPPEALRGADS;LVLLLLALLLPLLFYLRK;LVLLLLALLLPLLFYLRKR;PEPVEQFTQRDL;RVPAALRARH;RYLSTDPQHRTEDAVERVALEVQVG;TLAPEAWSAVELP 13 7.2 1.0034 -1.5711 0 6.09299 9.34452 0 5.14653 0 0 0 11.0867 11.1139 9.92865 0 5.69916 10.0824 11.7657 A0A8I3PEB7 A0A8I3PEB7_CANLF GID complex subunit 4 homolog GID4 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin ligase complex [GO:0000151] SLLYSGSKF;VEAPREPVPA 2 5 1.0019 -1.4157 0 0 8.44869 8.57418 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PEB9 A0A8I3PEB9_CANLF MutS homolog 3 MSH3 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910] MutSbeta complex [GO:0032302] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; dinucleotide repeat insertion binding [GO:0032181]; enzyme binding [GO:0019899]; single guanine insertion binding [GO:0032142]; single-stranded DNA binding [GO:0003697] AAAAAAVSPAPARQ;KYRFFGEDAEIAARELN;RRKLKKWVVQPLLKLREINARLDA;STNLSGDSERVM 4 6 1.0032 -0.78913 0 0 10.8801 0 0 0 0 0 0 6.84147 0 0 0 0 0 A0A8I3PEC1 A0A8I3PEC1_CANLF Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8) MED8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] core mediator complex [GO:0070847]; mediator complex [GO:0016592] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712] LVLSPDRDEDLMRQT;VLSPDRDEDL 2 5.6 0.99581 -0.084988 0 0 12.2221 5.61356 0 0 0 0 0 0 0 0 0 12.6109 0 A0A8I3PEC9 A0A8I3PEC9_CANLF Calcium release activated channel regulator 2A CRACR2A Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] ARKDMQRLHEELP;GIDYQVKMVRVDDSYVALQLWDTA;NELECALKKKIAAYDEEIQHLYEE;NSLGLSGYPFPE;VGHMDDDEETQ 5 12.1 0.98694 -0.38286 7.51735 0 0 4.08398 9.99223 0 12.3103 0 0 0 0 8.38046 0 0 0 A0A8I3PED1 A0A8I3PED1_CANLF Dynein regulatory complex subunit 3 DRC3 Canis lupus familiaris (Dog) (Canis familiaris) axoneme [GO:0005930]; sperm flagellum [GO:0036126] ETINMFERNIIDL;LVEQLEETINMFERN 2 3.6 0.98966 -0.22242 0 0 0 0 8.37295 0 0 0 0 0 0 0 0 0 0 A0A8I3PED5 A0A8I3PED5_CANLF Cysteinyl leukotriene receptor 1 CYSLTR1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935]; establishment of localization in cell [GO:0051649]; inflammatory response to antigenic stimulus [GO:0002437] plasma membrane [GO:0005886] leukotriene receptor activity [GO:0004974] EPPQDNQAK;HVLVLHYVSLFVG;SAFQVYMINLAV 3 10 1.0026 -0.75831 0 8.40973 0 0 0 0 8.72253 0 0 0 0 9.09376 14.6984 0 0 A0A8I3PEE0 A0A8I3PEE0_CANLF Olfactory receptor OR51B4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DLGMTLTTMPTVL;SIPFFMIY;VHITMSYVYFLF 3 10.6 1.002 -1.2693 0 0 0 0 9.55445 0 0 0 0 0 0 8.65335 10.5831 0 0 A0A8I3PEE7 A0A8I3PEE7_CANLF Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DUSP6 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of apoptotic process [GO:0043065]; regulation of heart growth [GO:0060420]; response to nitrosative stress [GO:0051409] cytosol [GO:0005829]; nucleoplasm [GO:0005654] MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine/threonine phosphatase activity [GO:0008330] GISRSVTV;LEGGFSKFQAEFA;LPVLGLGGLRISSDSSSDIESDLDR 3 12.1 0.93923 0.059747 0 0 0 0 0 0 0 9.75632 0 0 0 0 0 0 0 A0A8I3PEF0 A0A8I3PEF0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APTDEEQSVTETDA;FNHKRFWHLT 2 28.9 0.99195 -0.54951 0 8.60207 0 0 0 0 0 0 0 0 0 0 0 11.2127 0 A0A8I3PEF3 A0A8I3PEF3_CANLF Olfactory receptor OR51K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVQEDPVLHEP;KLNSILGLAIVLATFGLDSLL;VLILYTVLGI 3 13.4 1.0025 -0.72648 0 0 0 0 0 0 0 0 5.62273 0 0 0 0 0 3.75905 A0A8I3PEF8 A0A8I3PEF8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AVLARGFVW 1 10.3 1.0046 -0.80421 0 0 0 0 0 0 0 0 9.84704 0 0 0 0 0 0 A0A8I3PEG6 A0A8I3PEG6_CANLF Solute carrier family 17 member 9 SLC17A9 Canis lupus familiaris (Dog) (Canis familiaris) ATP export [GO:1904669]; lysosomal protein catabolic process [GO:1905146]; purine nucleotide import into lysosome [GO:0141013] chromaffin granule membrane [GO:0042584]; lysosomal membrane [GO:0005765]; mucin granule [GO:0098594] ADP transmembrane transporter activity [GO:0015217]; ATP transmembrane transporter activity [GO:0005347]; guanine nucleotide transmembrane transporter activity [GO:0001409]; purine nucleotide uniporter activity [GO:0160042] IGGEKVIL;VGSLLLDWYGWPSV 2 5 1.0027 -1.3513 0 0 0 9.20486 0 0 0 0 0 0 0 0 0 0 13.0344 A0A8I3PEH5 A0A8I3PEH5_CANLF Exocyst complex component 7 (Exocyst complex component Exo70) EXOC7 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; protein transport [GO:0015031] exocyst [GO:0000145] "phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]" ALSAIFLHNNYNY;DPLSSSACHSQYG;DVETDAYI;FLHRYGSVPFTKNP;GGAKGGSG;GGSRWAEAMIP;GRDDTLDVETDAY;ILRHLKQTKPEFDQVLQ;IPEHHQKK;LDRSIKGLK;RSYREHIE;TDAYIHCVSAF 12 15.6 0.99671 -4.2915 9.32825 0 0 12.0718 0 0 10.3904 0 11.5358 0 3.04154 8.29912 10.2035 0 0 A0A8I3PEJ3 A0A8I3PEJ3_CANLF Calmodulin regulated spectrin associated protein family member 2 CAMSAP2 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection development [GO:0031175] microtubule [GO:0005874] calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; spectrin binding [GO:0030507] ALSPCPSTV;ESVHSGKRTP;ETQLRKQQL;GVSFDISFDKENTVHRST;KRPVTPKKLLPNK;LVENLLKDGTDGCA;MEDMDTVI;QEFCQEYLNQCCHFTLEDML;RDLHKKPIQMVNEHLKD;SIEEELNIDSHSD;TSQSDHIANG;VTDQEKLVTERDLHKKPIQMVN 12 10.5 0.99908 -3.0642 9.82829 0 4.47288 0 0 12.4957 0 9.45109 8.8351 0 8.55409 0 8.10805 8.2717 6.04928 A0A8I3PEJ4 A0A8I3PEJ4_CANLF B-related factor 1 BRF1 Canis lupus familiaris (Dog) (Canis familiaris) transcription preinitiation complex assembly [GO:0070897] nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550] RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025] CKRREPIQASTAGE;GGSRPPAL;LDGAGKTPTL;NDYGCDGEEDDG;SVEDTTSS 5 7.7 1.002 -1.241 0 0 2.58535 0 0 0 7.12578 0 0 0 0 0 0 0 0 A0A8I3PEL7 A0A8I3PEL7_CANLF Olfactory receptor OR8S2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DFCEAQNIHHFSCEL 1 4.9 0.98267 -0.24817 0 9.77327 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PEM2 A0A8I3PEM2_CANLF Family with sequence similarity 234 member B FAM234B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDTTPKIGRGELRRF;RSWTLSLHSLHSQ 2 4.5 0.91758 0.11805 0 0 0 0 0 0 0 9.71829 0 0 0 0 7.55674 0 0 A0A8I3PEM5 A0A8I3PEM5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] early endosome [GO:0005769]; endosome membrane [GO:0010008] EIILWRNASEKLRKQRTNLHQRFE;NLVKGYDLIV 2 11.9 0.99147 -0.27584 0 0 0 0 0 0 0 0 0 0 0 8.97714 9.23216 0 0 A0A8I3PEN6 A0A8I3PEN6_CANLF Tyrosine-protein kinase (EC 2.7.10.2) ABL1 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154]; regulation of apoptotic process [GO:0042981]; regulation of cellular component organization [GO:0051128]; signaling [GO:0023052] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] AAVVVDAVNSDTVKPG;DLQSTGRQFDSSTFG;GWVPSNYITPVNSLEKHSWY;HYRINTASDGKLY;LEKDYRMERPEGCPEKVYELMRAY;PSQSLSQEAAGEA;TSNGVPALTTL;VQLLGVCTREPPF 8 11.7 1.003 -0.87358 0 0 12.7417 0 0 8.33642 0 0 0 0 12.4238 0 0 8.99941 0 A0A8I3PEN8 A0A8I3PEN8_CANLF High mobility group protein B1 (High mobility group protein 1) Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; chemotaxis [GO:0006935]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; immune system process [GO:0002376] endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] DDDDESSPEAM;DDDESSPEAMCHTEH;DEDEGEDDDDES;DEEDEEEGEEDEDEGEDDDDESSPE;EDEGEDDDDESSP;EDEGEDDDDESSPEAMC;EEDEDEGEDDDDESSPEAMCH;EEDEEEGEEDEDEGEDDDDES;EEEGEEDEDEGEDDDDESSP;GEEDEDEGEDDDDES;RSSSAPATG 11 18.4 0.9897 -0.22344 0 0 0 6.36473 8.10386 4.05233 6.83428 0 9.33416 0 0 0 0 0 6.99299 A0A8I3PEN9 A0A8I3PEN9_CANLF Leucine rich repeat containing 34 LRRC34 Canis lupus familiaris (Dog) (Canis familiaris) EAFVVDGHVYLAEVSNGLKKHYYW;GGSEAAPAGPPPLPPAPAPAPAAT;NLMFNDIG;PAPAPAATRAVLGEAP 4 14.8 1.0022 -0.65938 0 0 0 0 0 0 0 0 0 0 0 0 0 9.98014 10.6217 A0A8I3PEP2 A0A8I3PEP2_CANLF Sushi domain containing 2 SUSD2 Canis lupus familiaris (Dog) (Canis familiaris) DVVSFYHCCL;EDQLPNFL;KDVQALWSNEHALAWHL;SGHVHCVSPL;TRMAHQWHQ 5 6.6 1.002 -1.8313 0 0 0 0 0 0 0 0 0 0 0 9.86075 8.67299 0 0 A0A8I3PEP5 A0A8I3PEP5_CANLF Chromosome 14 open reading frame 39 C14orf39 Canis lupus familiaris (Dog) (Canis familiaris) meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] central element [GO:0000801] HKHEDYMQDQFAVYQE;IDFRQKENKMQV 2 4.8 0.99206 -0.54201 0 0 0 0 0 0 0 0 0 0 0 0 13.0631 13.3856 0 A0A8I3PEQ1 A0A8I3PEQ1_CANLF Small nuclear ribonucleoprotein polypeptide B2 LOC100686524 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" cytoplasmic ribonucleoprotein granule [GO:0036464]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005] U1 snRNA binding [GO:0030619] EQTATTASKKPGQ 1 5.8 0.93917 0.059836 0 0 0 0 0 8.94921 0 0 0 0 0 0 0 0 0 A0A8I3PEQ2 A0A8I3PEQ2_CANLF Eukaryotic translation initiation factor 4E family member 2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] ISIWNKTASDQATIAHI 1 9.2 0.98299 0.046227 0 0 0 0 8.59746 0 0 0 0 0 0 0 0 0 0 A0A8I3PER7 A0A8I3PER7_CANLF Large ribosomal subunit protein eL22 (60S ribosomal protein L22) RPL22 Canis lupus familiaris (Dog) (Canis familiaris) alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181]; translation at presynapse [GO:0140236] cytosolic large ribosomal subunit [GO:0022625]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; presynapse [GO:0098793] heparin binding [GO:0008201]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] APVKKLVAKGGKKKKQVLKFT;KKLVAKGGKKKKQVL;PVKKLVAKGGKKKKQVLK 3 16.4 0.85201 0.14935 0 0 0 0 0 6.53506 0 0 0 0 0 3.57616 0 5.47952 0 A0A8I3PES1 A0A8I3PES1_CANLF RNA binding motif protein 45 RBM45 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] FLQFGGNSGSQLPQIQ;LVSGKNVGYAKYADR 2 6.5 0.9932 -0.061185 0 0 0 0 0 0 0 0 10.4299 0 0 0 0 0 0 A0A8I3PES6 A0A8I3PES6_CANLF Semaphorin 5A SEMA5A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] AGCNVEYQPCNTNPCPE;ETDTSQCQ;LIYGIFTTNVNSI;PCPESWSEWSDWS;SLIQAVEWECD 5 5.9 1.0022 -1.2287 9.57323 0 0 0 0 0 0 0 0 9.93779 4.1112 0 0 3.99059 0 A0A8I3PEU3 A0A8I3PEU3_CANLF Ropporin-1-like protein ROPN1L Canis lupus familiaris (Dog) (Canis familiaris) motile cilium [GO:0031514] MDSDIHEV 1 3.7 1.0043 -1.1044 0 0 0 0 0 0 9.70016 0 0 0 0 0 0 0 0 A0A8I3PEV3 A0A8I3PEV3_CANLF Hypoxia-inducible factor 1-alpha HIF1A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] DAARSRRSKESE;EVFYELAHQLPLP;ISDNVNKYMGLTQFEL;SNDTETDDQQLEE;TELMGYEPEELL 5 8.9 1.0025 -1.1655 0 0 0 0 0 6.34012 0 0 0 0 0 0 10.4958 0 0 A0A8I3PEV4 A0A8I3PEV4_CANLF Ankyrin repeat domain 37 ANKRD37 Canis lupus familiaris (Dog) (Canis familiaris) GVTPSPAPRWAGLR;KMQLLDCNPEVDGVQHLLEA 2 11.3 0.98527 -0.25901 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2331 0 A0A8I3PEW5 A0A8I3PEW5_CANLF Neural EGFL like 1 NELL1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CTEHDECGSGQHNCDENA;FSCTEHDECGSGQHNCDEN;HCECRSGFHDDGTYSLSGE;LFCCPECDTRVT;PSCSGDCPH;SGLRDEIRYH;TDPDLQMDI 7 9.9 1.003 -2.3062 4.35346 0 0 0 0 9.2241 0 0 8.16682 0 8.72683 0 2.76035 0 11.6191 A0A8I3PEX8 A0A8I3PEX8_CANLF Apoptosis inhibitor 5 API5 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] nucleus [GO:0005634] RNA binding [GO:0003723] KLETNLRKLFDKL;KSTVTLSWKPVQ 2 5.6 0.99089 -0.22098 0 0 0 0 0 0 9.78714 0 10.216 0 0 0 0 0 0 A0A8I3PEY4 A0A8I3PEY4_CANLF Exosome component 2 EXOSC2 Canis lupus familiaris (Dog) (Canis familiaris) "CUT catabolic process [GO:0071034]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]" cytoplasmic exosome (RNase complex) [GO:0000177]; nuclear exosome (RNase complex) [GO:0000176] RNA binding [GO:0003723] QRMMLYDTSI 1 3.8 0.98417 -0.24367 0 0 0 0 0 0 12.2038 0 0 0 0 0 0 0 0 A0A8I3PEZ3 A0A8I3PEZ3_CANLF Fibulin 2 FBLN2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell-substrate adhesion [GO:0010811] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840] AGPHLPAQEGT;CEDVNECETQ;GACCATCVQQGCACEGYQYYDC;GVHQCGEGQVCHNLPG;GVSCEDQDECLM;LEPGACCATC;PEVRRPPEP;PGPPALGV;QDDGRTCRPESDP;RKYAAGHTAH;TELPNSLPGD 11 9.7 0.99761 -3.7496 7.54504 13.699 7.69216 0 5.59583 0 5.24291 9.64532 0 0 0 8.16174 0 0 10.2937 A0A8I3PF02 A0A8I3PF02_CANLF V-type proton ATPase subunit G Canis lupus familiaris (Dog) (Canis familiaris) vacuolar proton-transporting V-type ATPase complex [GO:0016471] "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" ATRRQMQGMQSSQQRN 1 17.6 0.98214 -0.25112 0 0 0 0 0 0 0 0 8.62245 0 0 0 0 0 0 A0A8I3PF03 A0A8I3PF03_CANLF Cyclic nucleotide binding domain containing 2 CNBD2 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] cytosol [GO:0005829] cAMP binding [GO:0030552] DLVRLLVKPRQRPPF;ESESESESEEGEEEEEEEEEQEEE;FEESESESESEEGEEEEEEEEEQ;GHFPPKAMQITQ;LVRLLVKPRQRPPFIPVRPKKKE;RGFREYQIIETS;SWRTESEIQALCNLLQ;VERFKEFQIKSYPVQDFSS 8 16.7 0.99142 -0.301 0 12.0929 6.5086 0 11.4573 4.73915 0 0 5.78319 0 6.94462 0 0 0 0 A0A8I3PF11 A0A8I3PF11_CANLF Olfactory receptor OR7C19 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLKLACSNTFTNNV 1 4.5 0.93957 0.075435 0 0 0 0 0 0 0 0 0 0 0 0 0 6.05845 0 A0A8I3PF13 A0A8I3PF13_CANLF Armadillo repeat-containing domain-containing protein GPRASP1 Canis lupus familiaris (Dog) (Canis familiaris) DEDDPCMYT;DEIIFESWFWSGKK;ETIIGPWLWATEEV;FCNKSSPE;RHLTTTTDYHTLVAKYMSGFL;VGFPSPIPF;VIFGSWFWAEEDD 7 6.4 1.0028 -2.468 9.5652 11.2602 11.66 0 0 0 0 0 7.45615 0 0 0 0 0 8.71304 A0A8I3PF16 A0A8I3PF16_CANLF MCF.2 cell line derived transforming sequence-like 2 MCF2L2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] DLQIYFKYHKN;KDIYEDEENGKQI 2 2.4 0.99394 -0.1298 0 0 8.96601 0 6.6632 0 0 0 0 0 0 0 0 0 0 A0A8I3PF22 A0A8I3PF22_CANLF Coatomer subunit epsilon (Epsilon-coat protein) COPE Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] LAVDSGHPETLINL;VDSGHPETLINLIVL 2 6.6 0.86443 0.13571 0 8.22023 0 4.53966 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PF32 A0A8I3PF32_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] GVELWREGRGFPQ;GVELWREGRGFPQG 2 10.8 0.99261 -0.19146 9.13389 0 0 0 0 0 8.97633 0 0 0 0 0 0 0 0 A0A8I3PF34 A0A8I3PF34_CANLF Debranching RNA lariats 1 DBR1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleoplasm [GO:0005654] metal ion binding [GO:0046872]; RNA lariat debranching enzyme activity [GO:0008419] FQAVRNEA;IVSSDDTLGS;IYETLALAERRGPGPID;QTAKATKFLALDKCLPHR;SHDYRKGHFECPPYNPATIRSI 5 13.8 1.0022 -0.68595 0 0 0 0 10.411 0 0 0 10.1452 12.2633 0 0 2.88341 0 0 A0A8I3PF42 A0A8I3PF42_CANLF Coiled-coil domain containing 150 CCDC150 Canis lupus familiaris (Dog) (Canis familiaris) AEAKEDNCKVTIMLENVLASH;AERIEALRKQFQTE;ALKESQKL;ARIIADHQAILQVEQKMMTQTFQE;ELSQAVKCRDVALKESQ;ELTHNLQT;ESVNIISP;IAGLKKERALNQQRVQKLEAEVDQW;LDHLILEHNQ;LELQQVTSDYNGIKVK;SLLGEKER;VLHRWENKQNLKLMPKKC 12 16.2 1.0008 -2.7424 11.8767 0 0 6.21673 0 0 12.2385 12.8322 12.223 0 4.43229 12.9851 0 0 0 A0A8I3PF51 A0A8I3PF51_CANLF Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (Peptidase M) (p67) (p67eIF2) METAP2 Canis lupus familiaris (Dog) (Canis familiaris) protein processing [GO:0016485] cytosol [GO:0005829]; plasma membrane [GO:0005886] initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] ATGKKKKKKKKKR;ATGKKKKKKKKKRGPK;ERDDDDEDGD;GATGKKKKKKKKKRG;GATGKKKKKKKKKRGPKVQT;GKKKKKKKKKRGPKVQ;KKKKKKKK;KKKKKKKKKRGP;KKKKKKKKKRGPK 9 6.3 1.0001 -0.61653 0 4.60259 4.84604 7.31216 6.15257 0 0 0 0 0 0 0 4.54275 0 0 A0A8I3PF54 A0A8I3PF54_CANLF Netrin receptor UNC5 UNC5C Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; brain development [GO:0007420]; chemorepulsion of axon [GO:0061643]; dorsal root ganglion development [GO:1990791]; ectopic germ cell programmed cell death [GO:0035234]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental process [GO:0051094]; positive regulation of reproductive process [GO:2000243]; regulation of neuron migration [GO:2001222] dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] netrin receptor activity involved in chemorepulsion [GO:0005043]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631] MQSFLYPISTEQR;RVDETSGLIVRE 2 2.6 0.59809 0.37801 0 0 12.9118 8.88277 0 0 0 0 11.9979 0 0 0 0 0 11.8022 A0A8I3PF61 A0A8I3PF61_CANLF Semaphorin 3B SEMA3B Canis lupus familiaris (Dog) (Canis familiaris) semaphorin receptor binding [GO:0030215] FDQLRPFPTEDVFLLSLRDRWS;LVEPGGGGAGSL;PGAEGDTHFDQLRP;RKVFGVEGGSAF;VYSMNDVRRAFLGPFAHKEGPMHQ 5 10.4 0.94416 0.05044 0 0 0 0 0 0 0 0 0 0 0 5.28566 7.50589 0 6.79312 A0A8I3PF69 A0A8I3PF69_CANLF Empty spiracles homeobox 1 EMX1 Canis lupus familiaris (Dog) (Canis familiaris) brain morphogenesis [GO:0048854]; cerebral cortex neuron differentiation [GO:0021895]; cerebral cortex regionalization [GO:0021796]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; neuron projection extension [GO:1990138]; post-embryonic development [GO:0009791]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; response to xenobiotic stimulus [GO:0009410] chromosome [GO:0005694]; nucleolus [GO:0005730] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PESEQKKKGSH;RKPKRIRTAFSPSQLLRLE 2 10.3 0.94661 0.084971 0 4.57495 0 0 0 0 6.77017 0 0 0 0 0 0 0 0 A0A8I3PF71 A0A8I3PF71_CANLF Myelin transcription factor 1 like MYT1L Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DDDDDEEE;DDDDDEEEDNEDHQMSCHNS;DDDDEEEDNEDH;DEEEDEEEEDDDDDEEEDNEDH;DEEGDREEEEELEEEEDDDDED;EDDDDDEEE;EDEEEDEEEEDDDDDEEEDNEDH;EDEEEEFSEDED;EEEDDDDE;EEEEDDDDDEEEDNEDHQ;ESDEEVCLSSLECLRNQCFD;LEEEEDDDDEDG;QELKCPTPGC;RQEDDFAGRTPDRNYSDMMNLMRL;SETNPQDRSQQQ;TAILNLSTRCREM 16 12.8 0.98747 -0.33433 0 5.26236 0 0 5.2021 7.75422 0 10.7163 3.33814 5.06987 0 10.3493 11.0226 7.8069 5.20504 A0A8I3PF81 A0A8I3PF81_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] DQEILNIIQEKLKACQQQE 1 11.9 0.95437 0.05194 0 0 0 0 8.66807 0 0 0 0 0 0 0 0 0 0 A0A8I3PF89 A0A8I3PF89_CANLF Dynein axonemal assembly factor 8 (Dynein axonemal-associated protein 1) DNAAF8 Canis lupus familiaris (Dog) (Canis familiaris) dynein axonemal particle [GO:0120293] dynein complex binding [GO:0070840] GGDPGGPVE;LPSLDSDSSLSDCGTEELFI;PSEPSDVGALESPS 3 8.2 0.98668 -0.35732 0 0 0 0 0 0 8.77291 9.02178 0 0 0 0 0 0 9.17983 A0A8I3PF91 A0A8I3PF91_CANLF Mortality factor 4-like protein 2 MORF4L2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355] NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; plasma membrane [GO:0005886] EDWDLVTRQ;LAYTPLDEKSLALL;SGKKTAGPQQ 3 11.5 1.0039 -1.1025 0 0 9.71709 0 0 0 0 0 0 9.29809 0 0 0 0 0 A0A8I3PF97 A0A8I3PF97_CANLF Fatty acyl-CoA reductase (EC 1.2.1.84) FAR1 Canis lupus familiaris (Dog) (Canis familiaris) ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] peroxisomal membrane [GO:0005778] alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019] AGQTPQERVEEVI;ENLRDAVQLNV;GQKPWMMKTI;PAGGGGGA;RLHKAMVF;YSNNLLLHYWK 6 9.6 1.0032 -1.1165 0 0 0 0 0 0 10.0367 0 0 0 0 0 0 8.56556 0 A0A8I3PFA4 A0A8I3PFA4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ETVSKDVPQTGWGYWGSWGKCLLSS;HGQKQEVTAIE;LSHLEALEML;VLHGQKQEVTAIERSR 4 11.3 0.99025 -0.20163 0 0 8.47001 0 5.70592 8.78477 0 0 0 0 0 7.24698 0 0 0 A0A8I3PFB2 A0A8I3PFB2_CANLF Transmembrane protein 102 TMEM102 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell adhesion [GO:0045785]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to cytokine [GO:0034097]; signal transduction [GO:0007165] cell surface [GO:0009986]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991] EGARSHSW;LLGLVHRR 2 3.2 1.0026 -0.77615 0 0 0 0 0 0 0 0 0 0 0 0 0 9.06902 0 A0A8I3PFC9 A0A8I3PFC9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQPSCCNSSPCQEGC;EASPCCQQSSCQPSC;PCCQQSSCQPSCCNSSPCQEGCC;PPVCCTPVCCKPLCCESSPCC;PSCCNSSPCQEGCCVSVCC;QPSCCNSSPCQEGCC;QPSPCRPS;SCGSCSPCQEGCCM;SPCQEGCCMSVCC;VCCTPVCCKPVCCE 12 25.9 0.99127 -0.27586 0 0 0 0 0 0 0 0 0 0 0 0 0 6.48099 0 A0A8I3PFD5 A0A8I3PFD5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KLLKCEQNLGHNAMYWYK;VGSKKLLK 2 15.6 1.0036 -1.0561 8.64476 0 3.29016 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PFD7 A0A8I3PFD7_CANLF Vascular endothelial growth factor C VEGFC Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cellular response to leukemia inhibitory factor [GO:1990830]; glial cell proliferation [GO:0014009]; induction of positive chemotaxis [GO:0050930]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] extracellular space [GO:0005615]; membrane [GO:0016020] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; vascular endothelial growth factor receptor 3 binding [GO:0043185] VSVYRCGGCCNSEG 1 3.3 0.93333 0.060848 0 9.23326 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PFE1 A0A8I3PFE1_CANLF Myelin transcription factor 1 like MYT1L Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DDDDDEEE;DEEEEDDDDDEEEDND;DEEEEDDDDDEEEDNDPS;DEEGDREEEEELEEEEDDDDED;EDDDDDEEE;EDEEEDEEEEDDDDDEEEDNDPS;EDEEEEFSEDED;EEEDDDDDEEEDNDPS;EEEDDDDE;EEEEDDDDDEEEDNDP;LEEEEDDDDEDG;QELKCPTPGC;TAILNLSTRCREM 13 9.8 0.74085 0.24226 9.65252 0 0 8.63967 3.834 0 5.87386 0 0 7.60444 0 0 5.16394 0 5.45602 A0A8I3PFE7 A0A8I3PFE7_CANLF Pogo transposable element derived with ZNF domain POGZ Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] EELIASLEEQL;GVPQVFSQMTPVRP;KPTVGVPQVF;RQFSTPFQLQ 4 3 1.0036 -1.1076 0 0 0 0 0 0 12.0673 0 10.2871 0 0 0 0 0 0 A0A8I3PFF0 A0A8I3PFF0_CANLF Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) ASMT Canis lupus familiaris (Dog) (Canis familiaris) melatonin biosynthetic process [GO:0030187]; methylation [GO:0032259] O-methyltransferase activity [GO:0008171] ETKTGKALYQNTELSST 1 5.7 0.98394 0.046227 0 0 0 0 8.50668 0 0 0 0 0 0 0 0 0 0 A0A8I3PFF2 A0A8I3PFF2_CANLF Kelch like family member 6 KLHL6 Canis lupus familiaris (Dog) (Canis familiaris) EAQVFETVMSWVRH 1 2.5 0.93513 0.060938 0 0 0 0 0 0 0 0 0 0 0 0 6.87061 0 0 A0A8I3PFF9 A0A8I3PFF9_CANLF Insulin like growth factor 2 mRNA binding protein 2 IGF2BP2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; regulation of translation [GO:0006417] cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932] RNA binding [GO:0003723] DDEQALHREPE;EEEEEEEEEEEEEEEEEEEEKRRGQ;EEEEEEEEEEEEEK;EGALARSLSAAHTPVQ;EGRNLKKIEHETGTKITIS;GAEEEEEEEEEEEEEEEEEEEEK;GQEAAPGGTGPA;KEADETKLAEEI 8 12.2 0.64609 0.3268 0 0 0 6.56802 6.87566 11.2916 6.61343 9.88226 0 7.88649 0 0 0 0 6.32515 A0A8I3PFG7 A0A8I3PFG7_CANLF tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) ADAT1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] EVKIQQSG;GDASIIPMLEFEDQ;SPGRLVPCGAAISW 3 7.8 0.98527 -0.43944 0 0 0 11.1892 0 0 0 0 11.5891 11.3597 0 0 0 0 0 A0A8I3PFG8 A0A8I3PFG8_CANLF Orofacial cleft 1 candidate gene 1 protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLIQDLKFEGEGLNQ;VILPLVLIR 2 2.8 0.98915 -0.30603 0 0 0 0 0 0 10.6581 0 0 0 0 0 0 0 0 A0A8I3PFH0 A0A8I3PFH0_CANLF E74 like ETS transcription factor 2 ELF2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893] cytosol [GO:0005829]; nuclear body [GO:0016604] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" GVENQEESEKVSEYPAVIVEPVPS;KKPREGKG;VEGQRLVYQFK;YDDETYMMQDVAEE 4 9.6 0.99436 -0.16385 0 8.25333 0 0 0 0 12.9753 0 0 0 0 0 0 8.85786 0 A0A8I3PFH2 A0A8I3PFH2_CANLF Zona pellucida-like domain-containing protein 1 (Cupulin) ZPLD1 Canis lupus familiaris (Dog) (Canis familiaris) vestibular reflex [GO:0060005] cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; extracellular space [GO:0005615] DPQTTVIENGRSQ;PGLLYKFSCSYPLEYL;RFSFEVFRFV;SLLLCSLALLQRKTPT;WNVLMDYCYTTPSG 5 16.6 0.98953 -0.51815 0 10.2461 0 0 12.3319 0 9.83234 0 0 0 0 0 0 14.5182 0 A0A8I3PFH3 A0A8I3PFH3_CANLF Arrestin domain containing 1 ARRDC1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular transport [GO:0006858]; extracellular vesicle biogenesis [GO:0140112]; negative regulation of Notch signaling pathway [GO:0045746]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasmic vesicle [GO:0031410]; extracellular vesicle [GO:1903561]; plasma membrane [GO:0005886] arrestin family protein binding [GO:1990763]; identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] CLSHGRVVYSPGEPLVGA 1 4.2 0.99217 -0.18397 0 0 0 0 0 0 0 10.6264 0 0 0 0 0 0 0 A0A8I3PFI3 A0A8I3PFI3_CANLF phospholipase A2 (EC 3.1.1.4) PLA2G3 Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; arachidonic acid secretion [GO:0050482]; cell maturation [GO:0048469]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288] centriole [GO:0005814]; extracellular region [GO:0005576]; recycling endosome [GO:0055037] calcium-dependent phospholipase A2 activity [GO:0047498] QQIGPQETKFQ;VGTGEGQV 2 3.7 1.0036 -1.0689 0 0 0 9.64936 0 0 0 0 0 0 0 10.2184 0 0 0 A0A8I3PFI9 A0A8I3PFI9_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DLVDAQLSG 1 2 0.98555 -0.23614 0 0 0 0 0 0 0 0 0 0 0 0 0 9.71053 0 A0A8I3PFJ4 A0A8I3PFJ4_CANLF Tyrosine-protein kinase (EC 2.7.10.2) BTK Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; intracellular signal transduction [GO:0035556]; T cell receptor signaling pathway [GO:0050852] cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] EAEDSIEMYEW;FQTQQLLEMCKDVCEAMEYL;ITEYMANG;WSPPEVLMY 4 7.8 1.0023 -0.72729 0 0 0 0 0 0 7.904 9.36262 0 0 10.1471 0 0 0 0 A0A8I3PFJ9 A0A8I3PFJ9_CANLF High mobility group protein B1 (High mobility group protein 1) Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; chemotaxis [GO:0006935]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; immune system process [GO:0002376] endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DNA binding [GO:0003677] DEDEGEDDDDEP;DEDEGEDDDDEPCPGG;EDEDEGEDDDDEPCPG;EDEDEGEDDDDEPCPGG;EDEGEDDDDEPCPG;EEDEDEGEDDDDEPCPGG;EEGEEDEDEGEDDDDEPCPG;EGEEDEDEGEDDDDEPCP 8 10.1 0.565 0.40073 0 0 4.84097 6.01422 0 4.04247 4.0173 0 3.53568 0 3.21496 0 0 8.61996 0 A0A8I3PFK4 A0A8I3PFK4_CANLF Tyrosine-protein kinase (EC 2.7.10.2) FRK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] AGAKIHLN;MLGQNYRLPQPP 2 5.1 0.98941 -0.52127 0 0 0 0 0 0 0 0 0 0 0 0 0 9.78454 9.14034 A0A8I3PFL0 A0A8I3PFL0_CANLF Semaphorin 4C SEMA4C Canis lupus familiaris (Dog) (Canis familiaris) cell migration in hindbrain [GO:0021535]; cerebellum development [GO:0021549]; muscle cell differentiation [GO:0042692]; neural tube closure [GO:0001843]; positive regulation of stress-activated MAPK cascade [GO:0032874]; semaphorin-plexin signaling pathway [GO:0071526] postsynaptic density [GO:0014069]; synaptic vesicle membrane [GO:0030672] semaphorin receptor binding [GO:0030215] LVLLLLVLSLRRRL;PPSPPPGIPGQPLPSP;PSVTLEARAPL;VGGHSGSL 4 5.9 1.0024 -0.9589 8.59354 0 0 4.5579 0 6.60403 0 0 0 0 0 0 6.91157 0 0 A0A8I3PFL5 A0A8I3PFL5_CANLF Olfactory receptor OR9G10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LPPLVKLACDVK;TAMYFFIGNLSFL 2 8 0.98924 -0.50775 0 0 0 6.85773 0 6.23565 0 0 0 0 10.4791 0 0 10.9533 0 A0A8I3PFL8 A0A8I3PFL8_CANLF Zinc finger protein 638 ZNF638 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] APLVNSLNLGIANP;ESAQSMYSFLKQ;EVYNLVKP;GVPDVPEDLDFL;KIFQPFGKVNDVLI;LVTVDEIQDDSSDL;SEKSNMDEKEENEFNS;SELDYRDITKQ;TDEVKNEFRS;TEQSPQVQSRYTKE;YTCFPISMDGNQL 11 6.6 0.98491 -0.25482 0 0 0 0 0 0 0 0 9.81591 0 0 0 0 0 0 A0A8I3PFL9 A0A8I3PFL9_CANLF Microtubule associated scaffold protein 2 MTUS2 Canis lupus familiaris (Dog) (Canis familiaris) ALLLPVLRPLRI;LANIRDEVAFNTAKCEKLQKEK;LASQPAGMGHCCCKPYNCL 3 12.3 0.93949 0.099986 0 0 0 6.18963 0 0 0 0 0 0 0 0 0 4.29638 0 A0A8I3PFM9 A0A8I3PFM9_CANLF Anion exchange protein SLC4A5 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] FLAPILKILGLIIVRRLLDLIFS;GISVFLAPILKILGLIIVRRLLDL;INMDFKPDSITTYKCECVAPDT;IVLPPGEW;LAPILKILGLI;LAPILKILGLIIV;LAPILKILGLIIVRRLLDLI;PILKILGLIIVRRLLDLI;PSADKRKSVFSLMELRQ;QPFIAFVRLIQ 10 8.2 1.0015 -0.69616 6.2218 5.33439 0 9.61677 0 0 7.58436 0 0 0 7.58045 4.09753 0 0 0 A0A8I3PFP5 A0A8I3PFP5_CANLF tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1) DTWD1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] nucleus [GO:0005634] tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432] EQMPLVKLPLK;QNVRDKNDDPDRPSIK;SVSIKDISFHLQKR 3 13.7 0.98826 -0.37509 0 0 9.10923 0 0 0 10.3271 0 0 0 8.3051 0 9.80752 9.47011 9.41646 A0A8I3PFP7 A0A8I3PFP7_CANLF Coiled-coil domain containing 150 CCDC150 Canis lupus familiaris (Dog) (Canis familiaris) AEAKEDNCKVTIMLENVLASH;AERIEALRKQFQTE;ALKESQKL;ARIIADHQAILQVEQKMMTQTFQE;ELSQAVKCRDVALKESQ;ELTHNLQT;ESVNIISP;IAGLKKERALNQQRVQKLEAEVDQW;KNKLAYEKGKLQIKVKQLE;LDHLILEHNQ;SLLGEKER;VLHRWENKQNLKLMPKKC 12 16.7 0.95126 0.04941 0 0 0 0 0 0 0 0 5.88465 0 0 0 0 0 0 A0A8I3PFQ1 A0A8I3PFQ1_CANLF [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) UTY Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GVKGLSNH;LNFLMSSWWP;SLQNKTKLLPSIEE;SSGPFAGG 4 3.1 1.0032 -2.4506 0 0 0 0 0 0 0 0 0 4.94664 0 0 9.84167 0 0 A0A8I3PFQ3 A0A8I3PFQ3_CANLF Cyclic AMP-dependent transcription factor ATF-4 (Activating transcription factor 4) ATF4 Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282]; cellular response to glucose starvation [GO:0042149]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; circadian regulation of gene expression [GO:0032922]; embryonic hemopoiesis [GO:0035162]; gluconeogenesis [GO:0006094]; HRI-mediated signaling [GO:0140468]; intracellular calcium ion homeostasis [GO:0006874]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; L-asparagine metabolic process [GO:0070982]; lens fiber cell morphogenesis [GO:0070309]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of transcription by RNA polymerase II [GO:0000122]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of osteoblast differentiation [GO:0045667]; regulation of synaptic plasticity [GO:0048167] ATF1-ATF4 transcription factor complex [GO:1990590]; ATF4-CREB1 transcription factor complex [GO:1990589]; centrosome [GO:0005813]; CHOP-ATF4 complex [GO:1990617]; cytoplasm [GO:0005737]; Lewy body core [GO:1990037]; neuron projection [GO:0043005]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654] "cAMP response element binding protein binding [GO:0008140]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" DAPSDNDSG;IPQCIKEEDAPSDNDSGICMSPESY;LETMPDEL 3 9.4 1.0022 -1.8731 0 0 0 0 0 0 0 0 5.28051 0 0 8.94096 6.59699 0 0 A0A8I3PFR8 A0A8I3PFR8_CANLF IgG receptor FcRn large subunit p51 (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) FCGRT Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008] IgG binding [GO:0019864] LGHLERGRGN;TAVSAPPPGTPAF;VGALLPTP 3 8.8 1.0031 -1.6561 0 0 0 0 0 10.6816 0 13.6547 0 0 4.88538 0 0 8.97016 0 A0A8I3PFS1 A0A8I3PFS1_CANLF Cohesin subunit SA (SCC3 homolog) (Stromal antigen) STAG1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; localization [GO:0051179]; mitotic spindle assembly [GO:0090307]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]" chromatin binding [GO:0003682] AEPIFEDVMM;ALVNVALNLSIHQ;HNPQMQISWLGQPKL;LSIHQDNTQRQYEAERNKMIGKRAN;PVTLFEVVKLG;VNVKLILLFIY;YSIIYDEYMMD 7 7.1 0.99706 -0.58949 0 9.38722 0 9.75889 13.4263 0 7.03133 16.3141 0 0 0 2.72607 9.58114 0 0 A0A8I3PFS4 A0A8I3PFS4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142] ILVIVVCFIPHH;INTTALPNASNT;VILRLLIYFQKL 3 12.2 0.98686 -0.45796 0 0 0 0 0 0 0 10.4936 0 0 0 0 0 0 4.33242 A0A8I3PFS9 A0A8I3PFS9_CANLF BAG family molecular chaperone regulator 5 (Bcl-2-associated athanogene 5) BAG5 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; protein stabilization [GO:0050821]; regulation of inclusion body assembly [GO:0090083] cytosol [GO:0005829]; inclusion body [GO:0016234]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] adenyl-nucleotide exchange factor activity [GO:0000774]; protein kinase binding [GO:0019901]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625] PAELYLSSKTELQ 1 2.9 0.94004 0.059697 0 8.86031 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PFT0 A0A8I3PFT0_CANLF Interferon regulatory factor 5 IRF5 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of type I interferon production [GO:0032481]; response to muramyl dipeptide [GO:0032495]; response to peptidoglycan [GO:0032494] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; transcription cis-regulatory region binding [GO:0000976]" AWGLGWGVSYSSCRSPD;DPLAMNQPAPRAPPP;GELSWSADSIRLQ;GPSQEGDNTIFKAWAKE;LEPTQDQV 5 11.6 1.002 -1.2288 9.8104 10.761 0 0 0 0 0 0 0 0 0 0 9.0175 0 0 A0A8I3PFT5 A0A8I3PFT5_CANLF RISC-loading complex subunit TARBP2 TARBP2 Canis lupus familiaris (Dog) (Canis familiaris) global gene silencing by mRNA cleavage [GO:0098795]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of defense response to virus by host [GO:0050689]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; regulation of miRNA processing [GO:1903798]; regulation of siRNA processing [GO:0070921]; regulation of translation [GO:0006417]; regulation of viral transcription [GO:0046782]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422] nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; siRNA binding [GO:0035197] HVSYLDIEELSL;LDIEELSLSGLCQCLVELSTQ;PLDSSLPEDIPVFTAAAAATPV 3 12.8 0.86495 0.15352 0 0 0 7.24793 0 0 0 0 9.85012 0 10.1007 0 0 0 0 A0A8I3PFU0 A0A8I3PFU0_CANLF Olfactory receptor LOC119863894 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] ITPTVLILASYLFIIGAILRIR 1 7.2 0.97341 0.046699 0 0 0 0 0 0 0 0 5.77976 0 0 0 0 0 0 A0A8I3PFU9 A0A8I3PFU9_CANLF CUB and Sushi multiple domains 1 CSMD1 Canis lupus familiaris (Dog) (Canis familiaris) conditioned place preference [GO:1990708]; female gonad development [GO:0008585]; glucose homeostasis [GO:0042593]; male gonad development [GO:0008584]; mammary gland branching involved in pregnancy [GO:0060745]; memory [GO:0007613]; oviduct epithelium development [GO:0035846]; startle response [GO:0001964] membrane [GO:0016020] EEDFDILSVYDGQLQQ;FFRCRKGY;FVVFGQFAYFQTALNDLAEL;GASISYSCVDGFQPS;GSSFLHGDTL;GTSSTISSPHFPSEYGNNADC;GYTLVGSH;ILSGFAFYLYKH;KDCVWLITVP;LTVDWFNATSSKVNAT;PAPYDNNLHCT;PPTCIAACGGNLTGPAGVI;PSCNAPCGGQYAGSEGV;RLLLLLRVLLLL;SGNSLFLAFRSDAS;SHWSGTLPHCTGNDPG;SIEAQLSEH;TQGSESITCILQ;VISCGDPGTLANGIQFGT;VLSGNHTE 20 7.6 0.99687 -5.5908 9.535 13.4502 10.6261 14.7037 7.32984 9.54637 11.2847 0 0 8.75238 0 11.3507 0 0 0 A0A8I3PFV2 A0A8I3PFV2_CANLF "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)" RSAD2 Canis lupus familiaris (Dog) (Canis familiaris) "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of protein secretion [GO:0050709]; negative regulation of viral genome replication [GO:0045071]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]" endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741] "4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]; metal ion binding [GO:0046872]" HVENLQKLRTWCR;IEGENSGEDALREAQRFVIS;VPESNQKMRD 3 11.9 0.98762 -0.5016 0 0 0 0 0 0 0 9.04139 6.69558 0 0 6.76195 0 0 0 A0A8I3PFV4 A0A8I3PFV4_CANLF PLAC8 like 1 PLAC8L1 Canis lupus familiaris (Dog) (Canis familiaris) SEDEQHLISSL 1 6.2 0.99369 -0.18839 0 0 0 0 0 0 0 0 0 0 0 0 0 11.8172 0 A0A8I3PFW0 A0A8I3PFW0_CANLF Frizzled class receptor 3 FZD3 Canis lupus familiaris (Dog) (Canis familiaris) "canonical Wnt signaling pathway [GO:0060070]; cell proliferation in midbrain [GO:0033278]; commissural neuron axon guidance [GO:0071679]; dopaminergic neuron axon guidance [GO:0036514]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; inner ear morphogenesis [GO:0042472]; motor neuron migration [GO:0097475]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; neural tube closure [GO:0001843]; positive regulation of neuroblast proliferation [GO:0002052]; post-anal tail morphogenesis [GO:0036342]; serotonergic neuron axon guidance [GO:0036515]; sympathetic ganglion development [GO:0061549]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" apical plasma membrane [GO:0016324]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium tip [GO:0032433]; lateral plasma membrane [GO:0016328]; neuronal cell body [GO:0043025]; presynaptic active zone [GO:0048786] PDZ domain binding [GO:0030165]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] FTFLTFLIDVTRFRYPE;GVPWPEDMECSRFPDCDE;LTDHSRHSSSHR 3 7.1 0.98914 -0.19785 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3321 A0A8I3PFW5 A0A8I3PFW5_CANLF XLR/SYCP3/FAM9 domain-containing protein LOC119868547 Canis lupus familiaris (Dog) (Canis familiaris) KWDTDMRKAQEQEAELAHMFQEQ;PREEDVGNEIQEMLQ 2 9.7 0.93866 0.10015 0 0 0 0 8.6915 0 0 0 0 0 0 0 0 0 4.08338 A0A8I3PFW6 A0A8I3PFW6_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF144A Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CIFCTLCLKQYV;CSCDTFSSGRTMSP;YPVEQMTTIAQ 3 10.6 0.93263 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.22677 A0A8I3PFX7 A0A8I3PFX7_CANLF Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) PTPN12 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229] non-membrane spanning protein tyrosine phosphatase activity [GO:0004726] CEAEQARTDY;GKIPEEFNVFN;KQLQLYEIHGAQKLADGVQ;PKPVLHMVSSEQHSTDL 4 7.9 1.003 -0.78404 0 0 8.27882 6.98345 0 0 0 9.05042 9.30067 6.76235 0 6.95942 7.1372 0 6.77123 A0A8I3PFY5 A0A8I3PFY5_CANLF Cytochrome P450 family 8 subfamily B member 1 CYP8B1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" FHKALSVKRNLEK;ICPGRFLATNEMKLFVLLMV 2 6.6 0.99064 -0.27471 0 0 0 0 6.16285 0 0 0 0 0 0 0 0 0 0 A0A8I3PFY9 A0A8I3PFY9_CANLF SPRY domain containing 3 SPRYD3 Canis lupus familiaris (Dog) (Canis familiaris) CTFWGLLPHHRD;EEEEEEEEEDGEEIEQEHEG;HYRFLNWRRRIREIREVRAFRYQER;ILDSEGDSDDSCDT;PGWLPDSV;QEGEEEEEEEEEEEDGEEIEQEH;VDSRTRFSPRAVQVERSGPRLSCYL 7 17 0.98428 -0.24185 0 0 10.1649 0 0 0 0 6.91001 0 0 7.47711 7.74813 0 6.50856 6.85262 A0A8I3PFZ3 A0A8I3PFZ3_CANLF Ubiquitin-ribosomal protein eS31 fusion protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] FAGKQLEDGRT;KNKHKRKKVKLAVLKYYKVDENGKI;LVLRLRGGAKKRKKK;SHFDRHYCGKCC;TTPKKNKHKRK;TTPKKNKHKRKKVKLAVLK 6 42.9 0.99419 -0.076985 8.49281 0 9.20557 8.33789 0 5.16418 0 6.64904 5.31488 0 0 0 0 0 0 A0A8I3PFZ6 A0A8I3PFZ6_CANLF Leucine rich repeat containing 31 LRRC31 Canis lupus familiaris (Dog) (Canis familiaris) IPELEELSLSWN;QPSNDAKETTT;VGDLLPMMQ;VGGNLKLLL 4 8.2 1.0034 -1.646 0 0 0 0 0 0 0 0 9.79824 0 0 0 0 3.45207 0 A0A8I3PG00 A0A8I3PG00_CANLF Protein kinase N2 PKN2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] GAENMIQMYSNGS;KIEVIRMQI;PKLQRQKKIFSK;TSEAPILTP;VIERRPKLQRQKK;VISPLELRMEE 6 6.3 1.0032 -1.515 5.92084 0 0 0 0 6.8627 0 0 9.70132 12.7787 0 0 0 13.4135 4.81619 A0A8I3PG01 A0A8I3PG01_CANLF G protein-coupled receptor 160 GPR160 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; receptor complex [GO:0043235] FVLLQVIILLLKVQ;GTWLPFVLLQVIILLLKVQIPAYI;LIILGKILLNILTLGM;LLFLIILGKILL 4 12.7 0.81306 0.20174 0 0 0 0 0 0 0 5.05181 0 0 5.59042 0 4.77852 0 6.37163 A0A8I3PG02 A0A8I3PG02_CANLF Ventricular zone expressed PH domain containing 1 VEPH1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] plasma membrane [GO:0005886] ENTKGGEVDVGSMAEMAQEADD;QPLIEGKLKEKQVRWKFIKRWKTRY;SLALHTVLTKSL 3 6.9 0.99427 -0.18884 0 0 0 4.45582 4.24283 0 0 0 0 0 0 0 0 0 8.92264 A0A8I3PG18 A0A8I3PG18_CANLF Olfactory receptor family 7 subfamily A member 67 OR7A67 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVVMYFATVL;IFFFPCSHHH 2 5.9 0.99438 -0.12524 0 0 0 0 0 0 0 0 9.47559 0 3.67987 12.0643 0 0 0 A0A8I3PG30 A0A8I3PG30_CANLF Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) LOC102152884 SNRPD3 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal snRNP assembly [GO:0000387] catalytic step 2 spliceosome [GO:0071013]; commitment complex [GO:0000243]; cytosol [GO:0005829]; pICln-Sm protein complex [GO:0034715]; precatalytic spliceosome [GO:0071011]; SMN-Sm protein complex [GO:0034719]; spliceosomal tri-snRNP complex [GO:0097526]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U4 snRNP [GO:0005687]; U5 snRNP [GO:0005682] RNA binding [GO:0003723] CSSCTVNICVC;GVPIKVLH 2 9.5 0.99548 -0.56779 0 0 0 0 0 0 0 0 0 0 0 0 0 13.2075 0 A0A8I3PG31 A0A8I3PG31_CANLF Suppressor of cytokine signaling 2 SOCS2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567] EAACCGGG 1 2.8 1.0037 -1.1044 9.30902 0 0 0 0 0 0 8.69905 8.65585 0 0 0 0 0 0 A0A8I3PG33 A0A8I3PG33_CANLF "Phosphatase, orphan 2" PHOSPHO2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; phosphatase activity [GO:0016791] HLTVENYHAHSCN;PMESSVIVWSSGVEI 2 11.6 0.87883 0.13821 0 0 0 0 0 0 0 0 0 0 0 0 7.28864 6.27583 0 A0A8I3PG39 A0A8I3PG39_CANLF "Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U2AF complex [GO:0089701] metal ion binding [GO:0046872]; RNA binding [GO:0003723] EAECRAALSLFNGRWYA;EEHERKLREEWDAQQRRQRQEQEQR;KAKRKKRRQEL;KPSREKYRAALRKAKRKKRR;LRKAKRKKRRQ 5 15 0.81292 0.20095 0 0 0 0 11.8858 0 0 0 8.47861 0 0 0 5.28876 0 9.38057 A0A8I3PG40 A0A8I3PG40_CANLF Family with sequence similarity 227 member B FAM227B Canis lupus familiaris (Dog) (Canis familiaris) CWKMQQPPRNIEEFLK;EFLASLSSSSSI;IHGTKKAPSTSIKD;YDCKEEECQEQPEMNCV 4 11.5 0.99187 0.0056463 0 9.14423 0 0 3.30482 0 0 0 0 9.97799 0 0 0 0 0 A0A8I3PG41 A0A8I3PG41_CANLF Casein kinase I isoform gamma-1 (EC 2.7.11.1) CSNK1G1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] APITAHAEVEVVEEAKYVMLFH;VGSVHVDS 2 6.3 1.0034 -1.0561 0 0 8.6462 0 8.25621 0 0 0 0 0 0 0 0 7.01324 0 A0A8I3PG49 A0A8I3PG49_CANLF Protein Wnt WNT9B Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] ARVDAHNTHMGIKAVKSGLRTT;CSREASCSSLCCG 2 9.8 0.92889 0.10679 0 0 0 0 0 0 0 0 7.38431 0 0 0 0 8.55854 0 A0A8I3PG66 A0A8I3PG66_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GPSSAYLVHVGYLCLAIGCITVLL;GYLCLAIGCITVLLGFS;PPRKVLFV 3 17 1.0028 -1.3468 0 0 0 0 0 0 9.70872 0 6.23896 0 0 0 0 0 0 A0A8I3PG68 A0A8I3PG68_CANLF Cortexin 2 CTXN2 Canis lupus familiaris (Dog) (Canis familiaris) VGILCIFLGLLII 1 16 0.95081 0.059561 0 0 0 0 0 0 0 0 4.46884 0 0 0 0 0 0 A0A8I3PG74 A0A8I3PG74_CANLF Cyclin B1 interacting protein 1 CCNB1IP1 Canis lupus familiaris (Dog) (Canis familiaris) reciprocal meiotic recombination [GO:0007131] synaptonemal complex [GO:0000795] ubiquitin protein ligase activity [GO:0061630] PLGNNSKFPLD;SAMSLCEDMLLCNY;VLDISSRALAFWTYQVHQERLYQEY 3 15.7 0.98987 -0.19863 10.4009 0 8.68499 11.5648 0 12.236 0 0 0 4.25217 0 0 10.2097 0 0 A0A8I3PG77 A0A8I3PG77_CANLF "SET domain containing 1B, histone lysine methyltransferase" SETD1B Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nuclear speck [GO:0016607]; Set1C/COMPASS complex [GO:0048188] histone H3K4 methyltransferase activity [GO:0042800]; RNA binding [GO:0003723] DDDDDDEDSEDQD;DDDDEDSEDQDES;DDDDEDSEDQDESENDDEDV;DDDEDSEDQDESENDDEDVAL;DEGQQSSGEDMEISDDEMPSA;EDDDDDDD;EDDDDDDDEDSE;EDDDDDDDEDSEDQDES;EEEDDDDDDDEDSEDQ;EEEEAAADESMAPVV;EEEEDDDDDDDEDSE;EEEEEDDDD;EEEEEDDDDDDD;EEEEEEDDDDD;EEEEEEDDDDDDD;EEEEEEDDDDDDDEDSEDQD;EEEGEEEEEEEDDDDDDDE;EFRRAPVPPPLPPTEPL;EGEEEEEEEDDDDD;ESSESSEFESSSESSSSSSEDEE;ISSSSSQLSPLAPFGTNSQ;KGETRMRFYELLVTGRYTP;LFAMEPIAAD;PISSSSSQLSPL;SEAIPPGP;SERESTEEEEEGEEEEEEEDD;SSESSEFESSSESSSSSSE;SSESSESSEFESSSESSSSSSE;STEEEEEGEEEE;TDEPPADTQGMSIPAQP;TGLPLPLPLPLPLPLALPV;VEELASCKEPPEE;VMQVDMSHVLGGQWGGMPMSFQMQ 33 13.1 1.0031 -0.78354 8.04297 6.47625 0 6.6389 8.64497 10.5356 10.4544 12.716 6.36128 0 10.0034 0 7.3779 9.39234 5.82772 A0A8I3PGA5 A0A8I3PGA5_CANLF Single stranded DNA binding protein 2 SSBP2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] single-stranded DNA binding [GO:0003697] GGMESHHM;VGPVPPGFFQALGGVPGS 2 7.6 0.98092 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 10.5056 0 0 A0A8I3PGA6 A0A8I3PGA6_CANLF Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 LINGO1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] epidermal growth factor receptor binding [GO:0005154] PLFTHPQP;SFKRLYRLKVL 2 2.5 0.99022 -0.26176 0 0 0 0 0 0 0 0 0 0 0 0 11.0988 0 0 A0A8I3PGA7 A0A8I3PGA7_CANLF X-prolyl aminopeptidase 3 XPNPEP3 Canis lupus familiaris (Dog) (Canis familiaris) manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006] APEKFRGLGVRIEDDVVVT;SNPTYYMSNDIPYT;VGHYLGMDVHDTPDM 3 10.2 0.99109 -0.2154 0 6.96174 0 0 0 0 0 8.95026 0 0 0 0 0 0 0 A0A8I3PGB1 A0A8I3PGB1_CANLF Uncharacterized protein LOC100684236 Canis lupus familiaris (Dog) (Canis familiaris) SIIIYYTSVSG;TPKALPPQ 2 20.4 1.0025 -1.1696 0 0 0 10.3015 0 0 0 0 0 0 8.91716 9.76432 0 0 10.024 A0A8I3PGB9 A0A8I3PGB9_CANLF Solute carrier family 18 member A3 SLC18A3 Canis lupus familiaris (Dog) (Canis familiaris) acetylcholine uptake [GO:0051630]; serotonin uptake [GO:0051610] synaptic vesicle membrane [GO:0030672] acetylcholine:proton antiporter activity [GO:0005278]; monoamine:proton antiporter activity [GO:0015311] FLVDVRHVSVYGS;LDALLLLVVAKPFS 2 5.3 0.99252 -0.065135 0 0 0 0 9.06811 0 0 0 0 0 0 0 10.7274 0 0 A0A8I3PGC4 A0A8I3PGC4_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP7 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] CSRTQNEGHPKWFVLG 1 7.2 0.96102 0.049233 0 0 0 0 0 0 0 0 9.74233 0 0 0 0 0 0 A0A8I3PGC5 A0A8I3PGC5_CANLF Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel development [GO:0001568]; intracellular signal transduction [GO:0035556]; negative regulation of cellular senescence [GO:2000773]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of p38MAPK cascade [GO:1900745] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] RSSSMKSLRILL 1 2 0.95322 0.05044 0 0 0 0 0 0 0 0 0 0 9.47322 0 0 0 0 A0A8I3PGD0 A0A8I3PGD0_CANLF ATP synthase lipid-binding protein (ATPase protein 9) (ATPase subunit c) LOC100685007 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial membrane [GO:0031966]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] EALGLFCLMV 1 7.1 0.99927 -0.61146 9.47583 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PGD1 A0A8I3PGD1_CANLF DExD-box helicase 39A DDX39A Canis lupus familiaris (Dog) (Canis familiaris) "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] PSEVQHECIPQ;QDRFEVNVAELP 2 5.4 0.94103 0.085931 0 0 0 0 0 8.43271 0 0 0 0 0 3.96791 0 0 0 A0A8I3PGD4 A0A8I3PGD4_CANLF F-box protein 36 FBXO36 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] LDLEDIARLSQT;VGQGPAPS 2 10.6 0.94646 0.080476 0 0 0 0 0 11.4649 11.6768 0 0 0 0 0 0 0 0 A0A8I3PGD7 A0A8I3PGD7_CANLF WW domain binding protein 11 WBP11 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] spliceosomal complex [GO:0005681] DDSDTDRSDGESEGDEFVHRDDNER;EDDSDDSE;EFSEDDDEDDSDDSEAE;EVEEFSEDDDEDDSD;QDKHDDSTDDSDTDRSD;QDKHDDSTDDSDTDRSDGE;SEDDDEDDSDDSEA;SEDDGYPEDMDQDKHDDSTDDSD 8 10.6 0.93213 0.107 0 4.08772 0 0 0 0 0 5.96574 0 0 0 0 0 0 0 A0A8I3PGD8 A0A8I3PGD8_CANLF rhomboid protease (EC 3.4.21.105) PARL Canis lupus familiaris (Dog) (Canis familiaris) signal peptide processing [GO:0006465] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] GCAFGSAA 1 2.7 1.004 -1.1044 0 0 0 0 0 0 0 0 8.10601 0 0 0 0 0 0 A0A8I3PGE5 A0A8I3PGE5_CANLF Retinoic acid receptor beta (Nuclear receptor subfamily 1 group B member 2) RARB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] LKACFSGLTQTEWQHRHTA 1 4.2 0.94983 0.049964 0 0 0 0 0 0 0 0 7.17971 0 0 0 0 0 0 A0A8I3PGF4 A0A8I3PGF4_CANLF Uncharacterized protein ZNF445 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EHQRIHTQEKPYK;GVALAGGE;NKFVLKHEPLEE;SIPIGKKCHKCSTCGKIFSKSSQ;TKCRKTFRWRSNFTRHMRMHQEENF;VGPFAKPI;YHYDYKEYGKGLRHIVGGFSL 7 10.8 1.0023 -1.4511 6.1131 9.88734 0 0 0 0 0 9.70129 9.88719 0 0 0 0 9.28378 3.6036 A0A8I3PGF7 A0A8I3PGF7_CANLF ADCYAP receptor type I ADCYAP1R1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] vasoactive intestinal polypeptide receptor activity [GO:0004999] GDQDYYYLSV;NDNTALWWVIKGP;TAMVILCRFRKLHCTRN;TTMHSDCI;VECKAIMVF 5 12.7 1.0033 -2.4368 0 0 0 9.50474 0 0 10.5915 0 0 0 9.13945 0 3.67593 7.0091 0 A0A8I3PGG2 A0A8I3PGG2_CANLF Tetratricopeptide repeat domain 39A TTC39A Canis lupus familiaris (Dog) (Canis familiaris) EECCEAQQHWKQFHHMCYWELMWC;FLTFVLGTGHVN;KDSLYPCERT;QTLCQRHRKK;RAVPALKLKIAGK 5 12 1.0037 -1.1074 8.84153 9.8573 0 0 0 0 5.59765 5.68207 0 0 0 0 0 0 0 A0A8I3PGG7 A0A8I3PGG7_CANLF High mobility group protein 20A (HMG box-containing protein 20A) HMG20A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] DNA binding [GO:0003677]; identical protein binding [GO:0042802] APQNTQLRREMETLM;AYKVFSRKTQDRQ 2 6.9 0.98822 -0.22762 0 0 0 0 9.15125 0 0 0 0 0 0 0 0 0 0 A0A8I3PGG8 A0A8I3PGG8_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) LOC100688437 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] AYHCSKCLEKVP;LVYVLYAVLV;SPASKTLSSPTDTLAP 3 7 0.95438 0.05188 0 9.65907 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PGH1 A0A8I3PGH1_CANLF Uncharacterized protein MTHFD2 Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrofolate interconversion [GO:0035999] mitochondrion [GO:0005739] methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] HVINVGRM;VISAAGVRKKAGYITP 2 9 0.99205 -0.18498 0 0 0 0 0 0 7.91211 8.82133 0 0 0 0 0 0 0 A0A8I3PGH2 A0A8I3PGH2_CANLF Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (Phosphotyrosyl phosphatase activator) PTPA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase activator activity [GO:0019211] GVKGKKLT;IDEIPPVDQPSRF;SSQLIDHPFLEPRHF 3 11.1 0.98978 -0.26592 0 0 0 0 0 0 0 0 0 10.5967 10.1649 0 0 0 0 A0A8I3PGH5 A0A8I3PGH5_CANLF LIM domain only protein 3 LMO3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AGVLINPP;NIKLLQAQGQTECIQM 2 7.3 1.004 -1.0552 0 0 0 0 0 0 10.304 10.5856 10.3876 0 0 0 0 0 0 A0A8I3PGI5 A0A8I3PGI5_CANLF Tuftelin 1 TUFT1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] HDRMEHLIE 1 2.7 1.0044 -0.80421 0 0 0 0 0 8.93263 0 0 0 0 0 0 0 0 0 A0A8I3PGI8 A0A8I3PGI8_CANLF Rho family-interacting cell polarization regulator 2 RIPOR2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; muscle organ development [GO:0007517]; negative regulation of signal transduction [GO:0009968]; sensory perception of sound [GO:0007605] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; stereocilium membrane [GO:0060171] DAFSGLFLALE;FLNTSDFDEEEEEDGDEVCN;FSSKTPFMVSNL;MLYLDAASRNEHFREKALLYYCE;TLEDVMEL 5 7.2 0.94412 0.077358 5.83547 0 10.6246 0 0 0 0 0 8.07494 9.51863 9.10135 9.74893 0 9.68496 0 A0A8I3PGJ2 A0A8I3PGJ2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LSRYLITQDAFGSLIL;QPNKRAFVAHSP 2 26.7 0.98832 -0.47245 0 0 0 0 0 0 0 0 0 12.7598 0 0 0 11.4661 8.93952 A0A8I3PGJ4 A0A8I3PGJ4_CANLF LamG-like jellyroll fold domain-containing protein PTX3 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] GGSGSPGP 1 1.1 0.99016 -0.26592 0 0 0 0 0 0 0 0 0 0 13.2367 0 0 0 0 A0A8I3PGK7 A0A8I3PGK7_CANLF Proline-serine-threonine phosphatase interacting protein 1 PSTPIP1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886] identical protein binding [GO:0042802] EDGWWTVERNGQ;PKASAVGASAETPSAAT 2 6.1 0.9421 0.10094 0 0 0 0 10.4285 10.5553 0 0 0 0 0 0 0 0 0 A0A8I3PGL7 A0A8I3PGL7_CANLF Uncharacterized protein ACTL11 Canis lupus familiaris (Dog) (Canis familiaris) AGEGKAPAKVL;EESSDHVQE;ENRTLTLPVDTRSD;GQPPLTGTPLARQLSLT;LVCTSRPGS 5 4.8 1.0021 -1.2764 0 6.63871 0 0 3.79442 0 0 9.49292 0 0 0 7.95722 0 5.04841 0 A0A8I3PGL8 A0A8I3PGL8_CANLF Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) MED9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] core mediator complex [GO:0070847]; mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] CMDKDSPDIHQDL 1 8.8 0.93979 0.059825 0 0 0 0 0 0 0 0 0 0 0 0 7.4054 0 0 A0A8I3PGM3 A0A8I3PGM3_CANLF STE20-related kinase adapter protein alpha (STE20-related adapter protein) STRADA Canis lupus familiaris (Dog) (Canis familiaris) protein export from nucleus [GO:0006611] cytoplasm [GO:0005737]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539] EQCLQRNPDV;PHFHHFVEQCLQRNP 2 4.8 1.0018 -0.91405 0 0 0 0 0 0 0 10.1419 0 0 0 0 0 0 0 A0A8I3PGM5 A0A8I3PGM5_CANLF Uncharacterized protein PSMC3 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome regulatory particle, base subcomplex [GO:0008540]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402] DELDAIGTKRFDSEKAGDREVQRTM;DGIGEEVLKMSTEEIIQ;DIGGLDKQ 3 12.6 0.98832 -0.47237 11.7151 0 0 0 0 0 0 10.3054 0 0 0 0 0 0 0 A0A8I3PGP5 A0A8I3PGP5_CANLF Intraflagellar transport associated protein IFTAP Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport particle A binding [GO:0120160] AVGGLDKQIEETL;LRVSSQCSEEEQIVID 2 11.9 0.99551 -0.092864 0 0 12.5666 0 0 0 0 0 0 0 0 0 7.56278 0 0 A0A8I3PGR2 A0A8I3PGR2_CANLF N-acetylaspartylglutamate synthase (EC 6.3.2.41) LOC119869240 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590] TERELLTKLP 1 3.5 0.99921 -0.61146 0 7.94656 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PGR3 A0A8I3PGR3_CANLF Inhibitor of growth family member 5 ING5 Canis lupus familiaris (Dog) (Canis familiaris) EGSDFESSGG;EYISTVKTLSPDQ;VDPNEPTYCLCHQVSYGEMIGCDN 3 20.8 0.98825 -0.47337 0 0 0 0 5.75788 0 0 0 0 0 0 0 0 8.81221 0 A0A8I3PGR6 A0A8I3PGR6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PGGTLTLTCGLSSGSVTTS 1 15.7 0.9494 0.04956 0 0 0 0 0 0 0 0 0 0 0 0 0 5.99829 0 A0A8I3PGR7 A0A8I3PGR7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SQIWDYSLPL 1 5.3 0.99548 -0.11707 0 0 0 0 0 0 11.3337 0 0 0 0 0 0 0 0 A0A8I3PGS3 A0A8I3PGS3_CANLF "Ras homolog family member F, filopodia associated" RHOF Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytosol [GO:0005829] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] APSVFEKYTAS;KAQRQKQHRLCLLL 2 12.1 0.92716 0.09626 0 0 0 0 0 8.04379 5.1199 0 0 0 0 0 0 0 0 A0A8I3PGT3 A0A8I3PGT3_CANLF Fuzzy planar cell polarity protein FUZ Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] PQSPTHGLRGLAT;VGSLPPQAA 2 5.7 0.93979 0.069697 9.55587 0 0 0 0 0 0 0 10.2945 0 0 0 0 0 0 A0A8I3PGU1 A0A8I3PGU1_CANLF Leucine-rich glioma-inactivated protein 1 LGI1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; synapse [GO:0045202] FTQVYNWDAEKA;NKRNFLFASSFKG;VISLLFTSNSFDVI;YSHQSLHAWYRDTDVE 4 10.8 0.98972 0.021288 0 0 0 0 12.0599 0 0 0 0 0 0 0 7.65012 9.73106 0 A0A8I3PGU2 A0A8I3PGU2_CANLF Filamin C FLNC Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] intracellular non-membrane-bounded organelle [GO:0043232] actin filament binding [GO:0051015] AEIAFEDRKDGSCGV;AGEAATFTVDCSEAGE;DIDFDIIKNDND;DMSGRYTIT;EGPHTVHVAF;GLGLADEV;HVLATEEPVVPAEPME;LAEDAPWKKIQ;LDSDKHTIRFIPHEN;LEFLEREHIKLVS;MWEDEDDEDARK;SIAVEGPSKAEIAFEDRKDG;VDCSEAGE;VDCSKAGTNMMMVGV;VHFAGAAKGEAVRD;VLFANQEIPASPFHI;YDGHPVPGSPFA 17 7.5 0.96319 0.049233 0 0 0 0 0 0 0 9.55447 0 0 0 0 0 0 0 A0A8I3PGU6 A0A8I3PGU6_CANLF Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) ORAI1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; store-operated calcium entry [GO:0002115] plasma membrane [GO:0005886] store-operated calcium channel activity [GO:0015279] PPPPAAVTYPDWI;VHLFALMISTCIL 2 9.3 0.9872 -0.23035 0 0 5.76152 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PGU7 A0A8I3PGU7_CANLF Amino acid transporter SLC1A2 Canis lupus familiaris (Dog) (Canis familiaris) L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712] plasma membrane [GO:0005886] glutamate:sodium symporter activity [GO:0015501]; L-glutamate transmembrane transporter activity [GO:0005313]; neutral L-amino acid transmembrane transporter activity [GO:0015175] IAQMNGVI;KQLGPGKKNDEVSSLDAF;LVIMIMWYSPLGI;MIMWYSPLGIACLICGK;RQLGMYMITVIVGLII;VANNMPKQ;VEFFNILNEIVM;VILVLAIHPG 8 15.8 0.98833 -0.26074 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.55359 A0A8I3PGV1 A0A8I3PGV1_CANLF "N-alpha-acetyltransferase 25, NatB auxiliary subunit" NAA25 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatB complex [GO:0031416] IFVSVLLKVIVFP;KLNLQKKKKKKKE;LFDRAQEQ;LRPYKLNLQKKKKKKKETSIIM;QKKKKKKK;SLLEIGELLKKRLETTKKLKI;VLRPYKLNLQKKKKKK;VLRPYKLNLQKKKKKKKET 8 6.5 0.98401 -0.25457 0 0 0 5.08245 0 6.56136 11.2973 0 5.49787 0 5.16659 11.0572 6.4614 0 0 A0A8I3PGX6 A0A8I3PGX6_CANLF Uncharacterized protein BEX5 Canis lupus familiaris (Dog) (Canis familiaris) LRRKIRELQLRYSLRIL 1 15.2 0.98633 0.046227 0 0 0 0 0 5.14029 0 0 0 0 0 0 0 0 0 A0A8I3PGX7 A0A8I3PGX7_CANLF TSPY LOC119868772 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283] nucleus [GO:0005634] EADDQEADEKKTDPEESD;EEEECEHEEDSGEESE;GAAADNREEAEEEGQ;GEEEECEHEEDSGE;GESQAVGEEEECEHEEDSG;PEVDDDSEQDDAE;VGEEEECEHEED;YVVSAAGYRASHSTPIQ 8 20 0.98638 -0.42551 8.02031 8.15598 0 8.48394 0 0 0 15.4902 11.2256 3.256 4.26664 0 4.91791 0 5.67773 A0A8I3PGX8 A0A8I3PGX8_CANLF Myosin light chain 4 MYL4 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048] A band [GO:0031672]; myosin II complex [GO:0016460] actin monomer binding [GO:0003785]; calcium ion binding [GO:0005509] EQGTYEDFV;LPRSLRNPDTRLAS 2 7.7 0.98781 -0.49652 0 0 0 0 0 0 9.12789 0 0 0 0 9.81362 0 0 0 A0A8I3PGY4 A0A8I3PGY4_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD7A Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] EAGPPAVG;ESLARAGPGALPGAAGAAGAAGAAE;LVYTEEEWERE;SGRGGPGP;STSPSEKTTPS 5 6.6 1.0028 -1.5863 0 0 10.6178 0 0 0 0 0 9.19609 0 0 9.39071 0 0 6.84474 A0A8I3PGY8 A0A8I3PGY8_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCE1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol phospholipase C activity [GO:0004435] ANNEEEEDEEDEYDYDYESLSD;CDDYDALDDKYLCFEDSCQ;DEEDEYDYDYESLSDDLPL;DLQLPLSYYYIES;DTKPIVTDYFLMEEK;EDEEDEYDYDYESL;EEDEEDEYDYDYESLSD;EEEEDEEDEYDYDYE;GLTSSQVLASESVQ;INSDLPIIISI;KHTAKMLF;LIDLQPLIQ;LRRKVLLKNKKLKAHQTPV;MKLCPRYNSQE;NNEEEEDEEDEYDYDYESL;NNEEEEDEEDEYDYDYESLSD;PSPDQLRRKVLLKNKKLKAH;QLRRKVLLKNKKLKAHQT;TKKKKKILI;VDYLYFLTRD 20 8.1 0.95394 0.04941 0 0 0 0 0 0 0 9.67294 0 0 0 0 0 0 0 A0A8I3PGY9 A0A8I3PGY9_CANLF Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) PRKCH Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; regulation of bicellular tight junction assembly [GO:2000810] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] DLMFHIQKSRRFDE;PTYNEEFCANVTDGGHLELA;TGILKSFMT;TPDYIAPEILQEMLYGP;VGLQPTRWSLRHSLFKKGY;VLTPIDEGHLPMINQDEFRNFSF 6 14.9 1.0019 -1.2087 0 9.0112 0 0 0 0 12.2494 9.74655 9.92679 0 0 0 0 0 0 A0A8I3PGZ2 A0A8I3PGZ2_CANLF "Trans-2,3-enoyl-CoA reductase" TECR Canis lupus familiaris (Dog) (Canis familiaris) fatty acid elongation [GO:0030497]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum membrane [GO:0005789] very-long-chain enoyl-CoA reductase activity [GO:0102758] LETLFVHRFSHGTM;PSSPPQIRSGTLLASP 2 7.9 0.9868 -0.23485 0 0 0 0 0 8.1982 0 0 0 0 0 0 0 0 0 A0A8I3PGZ6 A0A8I3PGZ6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GRVSGSWGA;LLSISSGRSLLRVRH 2 26.4 1.0017 -0.75034 0 0 0 0 0 0 0 0 0 4.07391 0 0 0 6.85162 0 A0A8I3PGZ9 A0A8I3PGZ9_CANLF Zinc finger MYND domain-containing protein 10 ZMYND10 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]; protein localization to cilium [GO:0061512] apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; dynein axonemal particle [GO:0120293] metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; protein folding chaperone [GO:0044183] DYCHRKLTMLVAR;LRYITDCVDSLS 2 5.7 0.99652 -0.57236 0 8.7738 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PH08 A0A8I3PH08_CANLF Zinc finger protein (EC 2.1.1.-) PRDM5 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; transcription cis-regulatory region binding [GO:0000976] QCDSSFTSEEILAE;SDMEADEEEQQ 2 5 0.92705 0.09626 0 0 0 0 5.98507 0 9.62379 0 0 0 0 0 0 0 0 A0A8I3PH12 A0A8I3PH12_CANLF PHD finger protein 20 PHF20 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965] metal ion binding [GO:0046872] DKEKNKEKKFKEFVRVKPKKKKKKK;DLTRRRSSRLSTNGTHEILD;EKNKEKKFKEFVRVKPKKKKKK;EWFCWDSPYLRPLEKIQL;KEFVRVKPKKKKKKKKK;KKFKEFVRVKPKKKKKKKKKTK;KKKKKKKK;KPKKKKKKKKKTKPE;NWYPAHIEDIDYEEGKVLIHFKR;PKKKKKKKKKTKPECPC;RVKPKKKKKKKKKT;SENDREYSGDAQ;SQEKSKTYSENTD;VKPKKKKKK;VKPKKKKKKKKK;VKPKKKKKKKKKTKP;VRVKPKKKKKKKK 17 11.8 0.98956 -0.52176 5.56955 5.73869 12.7893 0 0 11.7344 0 0 2.43568 0 0 3.73509 9.07371 3.23915 8.91157 A0A8I3PH14 A0A8I3PH14_CANLF N-arachidonyl glycine receptor (G-protein coupled receptor 18) GPR18 Canis lupus familiaris (Dog) (Canis familiaris) "CD8-positive, alpha-beta intraepithelial T cell differentiation [GO:0002300]; CD8-positive, gamma-delta intraepithelial T cell differentiation [GO:0002305]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of tumor necrosis factor production [GO:0032720]" cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FAFLMLEGD;KTSKLKPKVKEKSIRIIITL;LMNLSTCLD 3 11.5 1.0033 -1.5602 0 0 0 0 0 8.67465 0 0 0 8.05994 0 0 6.1456 4.77784 0 A0A8I3PH23 A0A8I3PH23_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EVGVGEPV;GPCVPPLE;LPSAVGAMSLATPQLPSPPLGP;QEHVSTSSASAG;QQLKVVASSTGWTVYHP;REESRQSQANAPVYQQNVLH;SELQSQQKQEIEALYR;SGDECPRRR 8 5.1 1.0019 -1.4338 0 0 9.39951 0 0 0 0 8.16466 7.30825 11.6488 9.5866 0 0 9.45826 0 A0A8I3PH27 A0A8I3PH27_CANLF RNA binding motif protein 39 RBM39 Canis lupus familiaris (Dog) (Canis familiaris) KKSKGPAQWTIYFN 1 14.9 0.93545 0.060932 0 0 0 0 0 0 0 0 0 0 0 0 5.27053 0 0 A0A8I3PH36 A0A8I3PH36_CANLF Solute carrier family 7 member 11 SLC7A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] YAGWFYLNF;YIRHTQGVLQNTGSVGMSL 2 6 0.98699 -0.23366 0 0 0 0 0 0 0 0 0 0 0 9.10842 0 0 0 A0A8I3PH42 A0A8I3PH42_CANLF Inositol-3-phosphate synthase 1 (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) ELL Canis lupus familiaris (Dog) (Canis familiaris) inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654] inositol-3-phosphate synthase activity [GO:0004512] RSSAKATRMT;VYGPNAIEAQYEYR 2 3.5 0.98791 -0.26083 0 8.1819 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PH49 A0A8I3PH49_CANLF DNA replication fork stabilization factor DONSON DONSON Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAGGGGGG;EQVISDEDEDESFSWLE;GGGGGGGG;MGVQDKIKKPDILSIKLRKEKH;PEPAPRRAALAAGLLLR;RGIREAMKNEGI;VDSNQENDSLW 7 19.1 0.97447 0.042226 8.95411 0 4.79764 0 0 0 0 7.72908 0 0 4.77057 0 11.7434 0 11.6829 A0A8I3PH55 A0A8I3PH55_CANLF RNA helicase (EC 3.6.4.13) DDX54 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ARAGLTEPVLI;DTKAAVLLHLL;GLDIPLLDNVINYSF;MSTGGGAPGAPGSLEAAQA;PQDQTVVFVATKHH;SELLTTQGVSCTHIYSAL 6 8.8 1.0033 -1.5617 9.38666 0 0 0 0 0 0 0 9.20026 0 0 0 0 10.673 0 A0A8I3PH59 A0A8I3PH59_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN22 Canis lupus familiaris (Dog) (Canis familiaris) non-membrane spanning protein tyrosine phosphatase activity [GO:0004726] DEFLKLKRQSTKYKADKI;LNTSDDSVR;RYKDILPYDHSRVE;SREWSGTSELNTSDDSVRLRPT 4 8.1 1.0018 -0.67544 0 0 0 0 0 0 9.26735 0 0 0 10.9612 0 11.5226 0 0 A0A8I3PH64 A0A8I3PH64_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) "canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]" 6-phosphofructokinase complex [GO:0005945]; membrane [GO:0016020] 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029] LKLRPILKIL;LKLRPILKILAK;QWRLKLRPILKILAKY;TDFDHHIPKEQWRL 4 23.2 0.98985 -0.528 0 0 0 9.71884 0 7.45582 0 0 0 0 0 0 0 0 0 A0A8I3PH72 A0A8I3PH72_CANLF FAST kinase domains 3 FASTKD3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitochondrial mRNA stability [GO:0044528] DWDTPEQNPSRVDEQT;LIDLLGARLYFASKVLTPYCYTI;LYQEGFCFLLKTFLRKY;NHLTSSEEVLSFVSTLQ;PYCYTIDVECI 5 12.2 0.99428 -0.026209 0 0 11.3008 0 0 12.0872 11.4511 0 0 0 0 9.87334 0 6.41865 9.8194 A0A8I3PH83 A0A8I3PH83_CANLF STARD3 N-terminal like STARD3NL Canis lupus familiaris (Dog) (Canis familiaris) cholesterol transport [GO:0030301]; vesicle tethering to endoplasmic reticulum [GO:0099044] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] cholesterol binding [GO:0015485] RFKVLILAYAVCRLR 1 6.9 0.9506 0.053874 0 0 0 0 0 0 0 0 0 0 7.96895 0 0 0 0 A0A8I3PH95 A0A8I3PH95_CANLF Solute carrier family 25 member 17 SLC25A17 Canis lupus familiaris (Dog) (Canis familiaris) peroxisomal membrane [GO:0005778] ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; NAD transmembrane transporter activity [GO:0051724] FHQIIRDE;VLSYESLVHA 2 7.7 1.003 -0.85343 0 0 0 8.47683 0 0 0 0 9.43085 0 0 0 0 0 0 A0A8I3PHA1 A0A8I3PHA1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TSNYPGWYQQ;TVVTQEPSL;TVVTQEPSLSVSPG 3 23.5 0.98861 -0.26445 0 0 0 0 0 9.8697 0 0 0 0 0 0 0 0 0 A0A8I3PHA5 A0A8I3PHA5_CANLF Oxidoreductase NAD-binding domain-containing protein 1 OXNAD1 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] PWGERGAPLVGLR 1 3.3 0.99002 -0.27352 0 0 0 0 0 0 0 0 0 0 0 0 12.4357 0 0 A0A8I3PHB2 A0A8I3PHB2_CANLF Tau tubulin kinase 2 TTBK2 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of protein localization to microtubule [GO:1902817]; regulation of cell migration [GO:0030334]; signal transduction [GO:0007165] centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; kinesin binding [GO:0019894]; protein serine/threonine kinase activity [GO:0004674] DLPGQQGDLSTF;IHSVGFLH;LRKIGGGG;NSIKTFGVIESD;SPQDEKLLLGPWAES;SQKSRSTTQCKSPGSPHNPKTP;VGILVKERWKVLRKIG;VLHKPCVPAV 8 7.9 1.0044 -2.0031 0 4.91169 0 0 0 11.8646 0 5.66332 9.74292 9.9969 10.3321 0 0 0 0 A0A8I3PHC8 A0A8I3PHC8_CANLF Casein kinase I isoform gamma-1 (EC 2.7.11.1) CSNK1G1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] KRKRKKTAQRH;VGSVHVDS 2 4.5 0.98075 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.67378 A0A8I3PHD4 A0A8I3PHD4_CANLF ATP binding cassette subfamily D member 1 ABCD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524] IAGLVVFLTANVLR;VVFLTANVLRAF 2 3.1 0.98498 -0.25929 0 0 0 0 0 0 7.46434 0 0 0 0 0 0 0 0 A0A8I3PHD8 A0A8I3PHD8_CANLF Solute carrier family 40 member SLC40A1 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] iron ion transmembrane transporter activity [GO:0005381]; metal ion binding [GO:0046872]; peptide hormone binding [GO:0017046] GVQNSMNYLLDLLHFIM;TIQGDRMWHFAVS;TQLLQENVIESERG;VILAPNPEAFG 4 9.8 0.99589 -0.10007 0 5.1311 8.17513 8.58553 9.16209 8.95603 0 0 0 0 7.62044 0 0 0 0 A0A8I3PHF0 A0A8I3PHF0_CANLF Gamma-crystallin C (Gamma-C-crystallin) CRYGC Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cytoplasm [GO:0005737]; nucleus [GO:0005634] structural constituent of eye lens [GO:0005212] DHKGLMVELSEDCSC;GFQGRCYE 2 12.9 0.9871 -0.2305 0 0 0 10.025 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHG1 A0A8I3PHG1_CANLF Vesicle amine transport 1 like VAT1L Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] IVEALGDSVKGYEIGDRVMAFVNY;VTGETKSFFSFAKSWWQVEKVN 2 11.8 0.99013 -0.53548 0 0 10.2159 0 0 0 0 0 0 0 0 0 9.77918 0 0 A0A8I3PHG4 A0A8I3PHG4_CANLF UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488] hexosyltransferase activity [GO:0016758] VTVGTTSFDDL 1 5.9 0.98534 -0.25862 0 0 0 0 0 0 0 0 0 0 0 11.4493 0 0 0 A0A8I3PHG9 A0A8I3PHG9_CANLF "Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2" PREX2 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; dendrite morphogenesis [GO:0048813]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; regulation of signaling [GO:0023051] plasma membrane [GO:0005886] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EIHRPEEGV;EVGTCFLHFKDKFRIYDE;IGEIHRPEEGVHL;LFDLEKVSFYFKPSE;LLVYCKRKHRRLK;LVSAFLHRM;SETQLRRDMV;VCSNINEAKRQMEKLE 8 5.8 1.0022 -1.1544 0 7.98356 0 0 5.06975 12.5472 0 0 0 0 0 0 10.2907 7.81429 11.6289 A0A8I3PHH2 A0A8I3PHH2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK24 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] DTDNQASGGSDSGDWIFTI;EDSDTETD 2 6.3 0.98738 -0.46076 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1243 A0A8I3PHH3 A0A8I3PHH3_CANLF TCDD inducible poly(ADP-ribose) polymerase TIPARP Canis lupus familiaris (Dog) (Canis familiaris) androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570] nucleus [GO:0005634] cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803] EQVVPIQDHSFPPE;LSTPPSSNVNSVYHTVWKF;NPENDRMRM;QNQFLWEKYKRKKEYMNRKMF 4 9.6 1.0007 -0.92876 0 0 0 6.37787 8.05398 0 11.5701 0 0 7.15198 6.13459 0 0 0 0 A0A8I3PHH6 A0A8I3PHH6_CANLF Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (Glutaminyl-tRNA cyclotransferase) QPCT Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270] SSSLRQVAEGTNISEMWENDLRPLL 1 6.9 0.99234 -0.17739 0 0 0 0 0 0 0 12.0547 0 0 0 0 0 0 0 A0A8I3PHI1 A0A8I3PHI1_CANLF EEF1A lysine methyltransferase 1 (EC 2.1.1.-) (N(6)-adenine-specific DNA methyltransferase 2) (Protein-lysine N-methyltransferase N6AMT2) EEF1AKMT1 N6AMT2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; protein-lysine N-methyltransferase activity [GO:0016279] GIIEENWQLSQFWY 1 6.5 0.98998 -0.21362 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.14423 A0A8I3PHI5 A0A8I3PHI5_CANLF Uncharacterized protein LIPI Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular region [GO:0005576] carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298] EKFKKKSCPRLGYQAELWKDAL;SISRIGLTYF;SLNVNFSTN 3 9.7 0.9843 -0.24019 0 0 10.7977 0 8.63292 0 0 9.02674 0 0 0 0 0 0 0 A0A8I3PHI6 A0A8I3PHI6_CANLF Olfactory receptor OR52AB3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIIIPAERSLHQ;LSTIYLLVPPALN;LVGILPVLIKR;LVTLVLVVAIRAMVLVGILPVLIK;TLVLVVAIRAMVLVGILPVLIKRLH;VLVGILPVLIKRL 6 16.5 0.99553 -0.014999 0 8.93937 4.71727 0 0 7.15239 0 0 6.01188 0 0 0 0 0 0 A0A8I3PHI8 A0A8I3PHI8_CANLF Uncharacterized protein SMPD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sphingomyelin phosphodiesterase D activity [GO:0050290] EYLEKALEYLCQMFRLSEAQLAQL;IAMEFLDPGGPMMKLVYKLQAEDYK;VLVVRLLLKHL 3 7.2 0.98985 -0.21363 0 0 0 0 0.929034 0 10.8842 0 0 0 0 0 8.11338 0 0 A0A8I3PHJ8 A0A8I3PHJ8_CANLF Negative elongation factor complex member B NELFB Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleus [GO:0005634] EQFQTENGVLLPSLQ;LHNFFSPSPKARRQ;QETLPRDS 3 6.1 0.98918 0.018015 0 0 0 0 0 0 0 0 0 0 0 0 10.4253 0 0 A0A8I3PHK0 A0A8I3PHK0_CANLF Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015] kinase activity [GO:0016301]; phosphatidylinositol binding [GO:0035091] EATYIQRTFEEFQ;FVFTSDMA;RIPITWAT;RMAVQWIGSLSDAELLDYLPQ;TYFTRLIESSLG;VGDFVLKPCGL;VLCDSLQEP;VYTFFHPL 8 5.6 1.003 -2.4233 0 9.83082 0 0 9.49317 11.2003 0 13.6754 11.6432 0 11.2694 0 11.3651 0 10.4117 A0A8I3PHK9 A0A8I3PHK9_CANLF Interleukin 3 receptor subunit alpha IL3RA Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] cytokine receptor activity [GO:0004896] EWKVLSHFNHRF;QSPKLVGPGTCWGGGVREE 2 7.2 0.98406 -0.25514 0 0 0 0 0 9.03837 0 0 0 0 0 0 0 0 0 A0A8I3PHL7 A0A8I3PHL7_CANLF Growth differentiation factor 5 GDF5 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; chondroblast differentiation [GO:0060591]; chondrocyte differentiation [GO:0002062]; embryonic limb morphogenesis [GO:0030326]; forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; mesenchymal cell apoptotic process [GO:0097152]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of multicellular organism growth [GO:0040014]; SMAD protein signal transduction [GO:0060395] extracellular region [GO:0005576] BMP binding [GO:0036122]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802] EAGLANTITSFIDKG;FSQRRKRRAPLATRQGKR;TVYEYLFSQRR 3 7.8 0.87817 0.13769 8.80925 0 0 0 7.45269 0 0 7.57221 0 0 7.49498 0 0 0 0 A0A8I3PHL8 A0A8I3PHL8_CANLF Single-pass membrane protein with coiled-coil domains 2 SMCO2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] QTDFLRETETTKWNTLELEAEHRQ;YILFFDAT 2 9.3 0.99468 -0.15281 0 11.7515 11.6407 0 0 0 0 0 11.1562 0 0 0 0 9.36192 0 A0A8I3PHM0 A0A8I3PHM0_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP3CC Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-mediated signaling [GO:0097720] calcineurin complex [GO:0005955]; cytoplasm [GO:0005737] calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872] CCGTECERGNLCYSETH;GCSYFYSYPA;LVNILNICSDDELI;TTVRKEIIKNKIRAI;VLFLWSLKINH 5 14.1 0.97678 0.046227 0 0 0 0 0 0 0 0 0 7.87627 0 0 0 0 0 A0A8I3PHM6 A0A8I3PHM6_CANLF Claudin CLDN1 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell junction maintenance [GO:0034331]; establishment of skin barrier [GO:0061436]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of wound healing [GO:0090303]; protein complex oligomerization [GO:0051259] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; virus receptor activity [GO:0001618] RKTTSYPTPRPYPKPAPS 1 8.5 0.97511 0.048313 0 0 5.83585 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHN7 A0A8I3PHN7_CANLF Platelet and endothelial cell adhesion molecule 1 PECAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AVSCQSINGTTPIS;EVTSPEPYQDFMENRYSR;GTYKCTVILNNKEKTSL;NHAMKPINENKEP 4 7.9 0.9933 -0.14321 0 0 0 0 9.75854 9.37771 0 0 0 0 0 0 0 8.58763 0 A0A8I3PHP3 A0A8I3PHP3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] actin binding [GO:0003779]; ATP binding [GO:0005524] LSLSPAGPGAVS;NAAVPAPCILAVN 2 3.2 0.99199 -0.54376 0 0 0 8.15436 0 0 0 9.56841 0 0 0 0 0 0 0 A0A8I3PHR7 A0A8I3PHR7_CANLF Zinc finger MYND-type containing 8 ZMYND8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] EGDWFCPECE;EVNTETLNKSSQ;LGLDSDSESELVI;PEGDWFCPECETD;SPVKKQRPLLPKE;TAGSQSPPETPLLTRSSSQTPTAG;VAADIAKYTSKMM;VIDLGEDHSG;YCWVCHREGQVLCCELC 9 10.4 0.93999 0.059561 4.27605 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHS0 A0A8I3PHS0_CANLF "MPL proto-oncogene, thrombopoietin receptor" MPL Canis lupus familiaris (Dog) (Canis familiaris) cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] thrombopoietin receptor activity [GO:0038164] AFEEVEPSPLEI;EDLTCFWDEEE;PFGTRYVCQFPAQEEVRLFFP;RFSRCHFKSRNDSI;RVLYVDSVGLPAPP 5 11.5 0.98712 -0.38316 0 0 0 7.96214 0 0 0 0 11.1262 0 0 0 9.13145 0 8.17817 A0A8I3PHS2 A0A8I3PHS2_CANLF Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) LOC607384 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleus [GO:0005634] LVMRLETKEQEVQE 1 8.4 0.98422 -0.25448 0 0 0 0 8.6207 0 0 0 0 0 0 0 0 0 0 A0A8I3PHS4 A0A8I3PHS4_CANLF DNA-binding protein SATB (Special AT-rich sequence-binding protein) SATB1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DLPPEQWSHTTV;EDPSPENRTLWE;MLPVFCVVEHYE;PPQAQAQQPSGP 4 6.3 0.98793 -0.32548 0 0 0 0 0 10.1704 0 0 0 0 0 0 4.85843 14.877 0 A0A8I3PHS5 A0A8I3PHS5_CANLF Profilin PFN2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779] AAGGGGGG;GGGGGGGE;GGGGGGGG;LVSQRRGGRR 4 4.8 0.99811 -0.097954 0 0 0 0 0 0 9.54427 0 0 0 0 0 0 0 0 A0A8I3PHS7 A0A8I3PHS7_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT15 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139]; transport vesicle [GO:0030133] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] CLQQPPWDSLPT;EDELTPLSLEE 2 3.6 0.99661 -0.57841 0 0 0 0 0 0 0 0 0 7.85006 0 0 0 0 0 A0A8I3PHT3 A0A8I3PHT3_CANLF "phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" PIP4P2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" PAAPPPLLLLPPLLLPL 1 3.3 0.97606 0.046227 0 0 4.75002 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHT8 A0A8I3PHT8_CANLF Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) IPPK Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838] nucleolus [GO:0005730] ATP binding [GO:0005524]; inositol pentakisphosphate 2-kinase activity [GO:0035299]; molecular adaptor activity [GO:0060090] FEHLQNIVDFS;GRQGRGEAVADRGSSPDGGGWCPG;HVITRVLLSGSDKG;MDEGKMDENEWGYHGEGN 4 11.5 0.92409 0.10823 9.16294 10.5331 9.22456 0 14.3686 0 0 9.39135 0 12.4011 12.1681 11.7129 9.79219 15.3006 15.1724 A0A8I3PHT9 A0A8I3PHT9_CANLF LisH domain-containing protein ARMC9 ARMC9 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] ESDDDEDEDDEFFCP;LESDDDEDEDDEFFC;LLDGVLESDDDED;SDDDEDEDDEFFC;SEVVRQYMARLI 5 5.5 0.85512 0.16731 4.55453 0 0 5.3548 0 0 6.08387 3.60715 0 0 0 4.34063 0 0 0 A0A8I3PHU4 A0A8I3PHU4_CANLF Semaphorin 6C SEMA6C Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] RHAGSPWEWNQN;RSCLASQDPYCG;RSQDMENCAVRGK;VLLEEINAYSPSRCNGKR 4 6 1.0022 -0.76376 0 0 0 0 0 6.42067 0 0 0 0 0 9.16123 0 0 11.5353 A0A8I3PHV0 A0A8I3PHV0_CANLF F-box protein 40 FBXO40 Canis lupus familiaris (Dog) (Canis familiaris) muscle cell differentiation [GO:0042692] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EGPPVNGEAGREE;PGGAVGGPHAGL;PLPGRHRHCEKCFNRH;SSSAFTFTCNKF 4 7.4 1.0018 -0.68275 0 8.53644 0 0 0 0 9.90916 0 0 0 0 0 10.536 0 9.54425 A0A8I3PHV1 A0A8I3PHV1_CANLF SIVA1 apoptosis inducing factor SIVA1 Canis lupus familiaris (Dog) (Canis familiaris) CGQCERALCGRCVHVCSSCG 1 18.2 0.97353 0.048206 0 6.0336 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHV9 A0A8I3PHV9_CANLF Profilin PFN2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; positive regulation of actin filament bundle assembly [GO:0032233]; regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737] actin binding [GO:0003779] YCGLGCLVMNFFHMCSVPY 1 10.1 0.95 0.049902 0 0 0 0 0 0 0 0 0 7.3427 7.65055 0 0 0 0 A0A8I3PHW1 A0A8I3PHW1_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP11 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] APRRRRLLLLLLLLLGGA;DPLVIELGQ;LLLLLLLGGAVGRAE;LLLLLLLL;LLLLLLLLGGAVGRAEAE;LLLLLLLLL;PKVSKKKLKEEKRNKSK;PRRRRLLLLLLLLL;RLLLLLLL;RLLLLLLLL;RPSAPRRRRLLLLLLL;RPSAPRRRRLLLLLLLLLG;RRLLLLLLLLLGGAVG;RRRLLLLLLLL;RRRRLLLLLLLLL;RRRRLLLLLLLLLGGAVGRAE 16 26.5 0.99254 -0.068287 9.82362 9.48087 9.20609 6.80193 0 5.46005 9.57314 9.19999 9.18026 9.56281 0 9.75564 10.0052 10.3516 10.9434 A0A8I3PHW5 A0A8I3PHW5_CANLF Uncharacterized protein UBE2R2 Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; ubiquitin-dependent protein catabolic process [GO:0006511] ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631] ADCYDDDDSGNEE;DCYDDDDSGNEE;DDEDEEEEDADCYDDDDS;DDEDEEEEDADCYDDDDSG;DDEDEEEEDADCYDDDDSGN;DDEDEEEEDADCYDDDDSGNE;DIDDEDEEEEDADCYDDDDS;DLYDDDIDDEDE;EDADCYDDDDSGN;EDADCYDDDDSGNEE;EDEEEEDADCYD;EEDADCYDDDDSGNE;EEDADCYDDDDSGNEE;EEEDADCYDDDDSGNE;EEEEDADCYDDDDSGN;ELKSLQEEPV;IDDEDEEEEDADCYDD 17 16.4 0.49091 0.48278 7.65928 0 8.22516 6.61708 0 5.35804 7.99209 6.17746 5.69916 5.76431 8.45376 0 7.19574 9.23161 0 A0A8I3PHW9 A0A8I3PHW9_CANLF F-box and leucine rich repeat protein 12 FBXL12 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] SCF ubiquitin ligase complex [GO:0019005] EQDPTVLPLLE;ISMAWLLKEQD;VTETGLDAGLQELSYLQ;WHLLRRYMASRLYS 4 15.3 0.8668 0.17803 9.41005 0 0 0 0 8.34243 9.40073 0 0 0 0 0 0 4.80503 0 A0A8I3PHX1 A0A8I3PHX1_CANLF Mitochondrial ribosomal protein S35 MRPS35 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543] mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] EADMEEYIWENSSSEKN;ISELTFSFQ 2 8.5 1.0024 -0.75799 9.98428 0 0 0 0 0 0 6.69711 0 0 0 0 0 0 0 A0A8I3PHX2 A0A8I3PHX2_CANLF SPEM family member 2 SPEM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALVPRGSR;NVGCCNQH;PSSALVPHSSQ;SHHHSRKMSQLRPVPFFDGE;TSYQRAPAPSSA 5 11.1 1.0031 -2.3021 0 0 8.42295 0 0 0 8.99297 0 0 9.62578 9.31915 9.31343 5.95789 0 0 A0A8I3PHX4 A0A8I3PHX4_CANLF 60S ribosomal protein L7a Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723] IKRRPVLGAGVNTVT 1 9.9 0.95222 0.053874 0 0 0 0 0 0 6.64049 0 0 0 0 0 0 0 0 A0A8I3PHY0 A0A8I3PHY0_CANLF Leucine-rich repeat-containing protein 37 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ELPQIPEEGEP;EVTVAPPG;LVTQDAPAGPAELPE;PAELSEDAGPTLVT;PSSTQQEAPTQY;TQELPAGPAELPEDAGPT;VTQEPPAGPAELPEDAVP 7 11.9 1.003 -1.728 0 0 0 0 0 0 0 0 9.89862 0 0 0 13.4097 0 11.0119 A0A8I3PHY2 A0A8I3PHY2_CANLF Phosphodiesterase (EC 3.1.4.-) PDE6C Canis lupus familiaris (Dog) (Canis familiaris) "phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; visual perception [GO:0007601]" "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" VERQFHKALYTVRTYL 1 1.9 0.96004 0.049233 0 7.39369 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PHY4 A0A8I3PHY4_CANLF Early growth response protein EGR1 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509]; cellular response to gamma radiation [GO:0071480]; cellular response to interleukin-8 [GO:0098759]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; estrous cycle [GO:0044849]; interleukin-1-mediated signaling pathway [GO:0070498]; locomotor rhythm [GO:0045475]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of post-translational protein modification [GO:1901875]; regulation of apoptotic process [GO:0042981]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of protein sumoylation [GO:0033233]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; skeletal muscle cell differentiation [GO:0035914]; T cell differentiation [GO:0030217] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; histone acetyltransferase binding [GO:0035035]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" GGGGGGGG;GGGGGGSG;LQYPPPTYP;LVETSYPSQTTRLP;PAAKGGFQVPMIPD 5 8.7 0.9931 -0.17054 0 0 0 0 2.2032 0 0 9.93409 0 0 0 0 0 0 0 A0A8I3PHZ3 A0A8I3PHZ3_CANLF XK-related protein XKR6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GGGCGGGGDG;VGFAQLHNLD 2 3.1 1.0023 -1.2229 0 0 0 8.56678 0 0 0 5.63358 0 0 0 0 2.68652 0 0 A0A8I3PHZ5 A0A8I3PHZ5_CANLF Ankyrin repeat and SOCS box containing 14 ASB14 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] LALKLLVPVTDLAAIKQS;MLDQRIRKHYDDHRKSALYFA 2 6.6 0.92556 0.095904 0 0 0 5.17848 0 5.48462 7.75489 0 0 0 0 0 0 0 0 A0A8I3PHZ6 A0A8I3PHZ6_CANLF BCL2 like 15 BCL2L15 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; nucleus [GO:0005634] AAPMTNMINGNNA;NGELEASA 2 12.9 1.002 -1.3645 0 0 0 0 0 0 0 0 0 9.6047 9.46056 0 0 0 12.3553 A0A8I3PI07 A0A8I3PI07_CANLF Metal transporter CNNM4 Canis lupus familiaris (Dog) (Canis familiaris) enamel mineralization [GO:0070166]; intracellular monoatomic cation homeostasis [GO:0030003]; magnesium ion homeostasis [GO:0010960] basolateral plasma membrane [GO:0016323]; protein-containing complex [GO:0032991] magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081] LISEKILLRLLKY;LRLLKYPDVIQELKF;NKTCGMNPDGI;RALMDLQYIKITRQQY;SLLSWLSDHSPSHPTTLSRSASLSY;TQLQDCFMIRSDAILDFN;VLGQEIRTVYNRE 7 13.2 0.98888 -0.21831 0 4.47534 8.5322 7.05268 0 0 0 0 4.43563 0 10.0402 0 0 10.3798 9.78449 A0A8I3PI12 A0A8I3PI12_CANLF Uncharacterized protein LOC100856762 Canis lupus familiaris (Dog) (Canis familiaris) EQYSAHNEITAISPSKPDKGS 1 5.6 0.97735 0.047551 0 0 5.04321 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PI15 A0A8I3PI15_CANLF Gigaxonin GAN Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] EIVRECNNIPL;FGAVACGVAMEL;IAAENCIGIRDFALHYCLHHVHY;MVMREILDYIFSG 4 10.7 1.0032 -0.78903 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3706 0 A0A8I3PI27 A0A8I3PI27_CANLF Family with sequence similarity 228 member B FAM228B Canis lupus familiaris (Dog) (Canis familiaris) SNSRHFMTPNKWLKVPTTYIESE 1 12.7 0.99148 -0.27211 0 0 0 0 0 0 8.73671 0 0 0 0 0 0 0 0 A0A8I3PI28 A0A8I3PI28_CANLF Tripartite motif-containing protein 10 TRIM10 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597] cytoplasm [GO:0005737] zinc ion binding [GO:0008270] HNYCRACL;LAHGGSCTVGVVREDVKRKGE;VGVVREDVKRKGELK 3 6.5 1.0022 -1.0007 0 0 0 0 0 5.59834 0 0 4.90569 0 0 0 0 0 9.55497 A0A8I3PI35 A0A8I3PI35_CANLF Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) ASNS Canis lupus familiaris (Dog) (Canis familiaris) glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981] asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524] EEESERLLKE;LDEVIFSLETYDI;VASVEMVKYHHCRDEPLHA 3 7.5 0.98637 -0.32249 9.79643 0 0 9.84806 0 0 0 0 10.3716 0 0 10.2335 0 0 0 A0A8I3PI38 A0A8I3PI38_CANLF Epidermal growth factor receptor pathway substrate 15 EPS15 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; endosomal transport [GO:0016197] clathrin coat of coated pit [GO:0030132] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] EKDPDMFCDSFTSTTTTTTTT;TDPVADTNLDF 2 4.2 0.946 0.082657 0 0 0 6.11497 0 0 0 0 0 0 0 0 11.1898 0 0 A0A8I3PI43 A0A8I3PI43_CANLF Nucleolar complex protein 3 homolog (NOC3 protein homolog) NOC3L Canis lupus familiaris (Dog) (Canis familiaris) fat cell differentiation [GO:0045444] mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730] RKLLKTSKVKLENKLKNKQFKQQ 1 2.9 0.97884 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 5.15822 0 0 A0A8I3PI49 A0A8I3PI49_CANLF RNA helicase (EC 3.6.4.13) DDX42 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] DDIEEEDDQEAYFRYMAENPTAG;EEEDDQEAYFRYMAENPT;GVNNTASG;KMDSKTDKTADG;LVFDEADRMFD 5 5.9 1.0025 -0.99061 0 0 0 8.92964 0 0 0 0 0 0 15.0479 0 0 0 10.6022 A0A8I3PI52 A0A8I3PI52_CANLF Small ribosomal subunit protein uS11 (40S ribosomal protein S14) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ESSPYAYMSAAQD;TFASFNDT 2 14.4 1.0018 -1.2536 11.1184 0 0 0 0 0 0 0 0 9.66156 9.61851 0 0 0 0 A0A8I3PI53 A0A8I3PI53_CANLF Solute carrier family 51 subunit beta SLC51B Canis lupus familiaris (Dog) (Canis familiaris) bile acid secretion [GO:0032782]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of protein stability [GO:0031647] basolateral plasma membrane [GO:0016323]; protein-containing complex [GO:0032991] bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982] LKEKDVSLVF 1 7.6 0.99131 -0.26992 0 0 0 0 0 8.36457 12.0028 0 13.5269 0 0 0 0 0 0 A0A8I3PI58 A0A8I3PI58_CANLF Microspherule protein 1 MCRS1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545] G-quadruplex RNA binding [GO:0002151] AKGASGVE;DEVLEHELTVAD;LTKRVKKSKQPLQVTKDL 3 8.2 0.98592 -0.41259 10.2832 0 0 4.98605 0 0 0 0 0 0 0 10.1929 0 0 0 A0A8I3PI64 A0A8I3PI64_CANLF TBC1 domain family member 4 TBC1D4 Canis lupus familiaris (Dog) (Canis familiaris) EVEYHVLQDELQ;ISPSLYAA;QFSLHEQQRLRL;SQKFEVLYC 4 4 1.0038 -0.80885 0 0 0 0 0 10.404 0 0 0 0 10.266 0 0 0 0 A0A8I3PI65 A0A8I3PI65_CANLF Uncharacterized protein PDCD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] IAPIWISGQNIPQE;LDWRCGHKQ;VGSMGEAPE 3 10.7 1.002 -0.90835 0 0 0 6.83908 0 7.83384 0 10.8394 0 8.28485 0 0 0 0 0 A0A8I3PI67 A0A8I3PI67_CANLF Telomerase associated protein 1 TEP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGELLARYRQALETA;AKPESESSFLVAGADG;EVKLWERPSMQLLG;IPEEETRRNRQLEVC;KLWERPSMQLLGLFQCEG;KSLVSGCDG;LSGPLSRGAKRLS;LYASSGPAEEQ;MSRNAKQDKTWT;NPNDVTLSGYSDGIL;PEPADQALKDKKLVLMS;PGAQPEEPAPTPEDNS;RTAGVLQAQAQAQLDRVVLFG;SEEKMPETELVE;TAHVLIAAQLWK;VLSLENRCLAMLPD 16 8.5 0.94294 0.059672 0 0 0 7.84987 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PI70 A0A8I3PI70_CANLF Glycerol-3-phosphate acyltransferase 3 GPAT3 Canis lupus familiaris (Dog) (Canis familiaris) glycerol-3-phosphate metabolic process [GO:0006072]; phospholipid biosynthetic process [GO:0008654]; regulation of TOR signaling [GO:0032006]; triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366] YMKILVKTLEWAT 1 3 0.93745 0.059576 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.10999 A0A8I3PI88 A0A8I3PI88_CANLF Armadillo repeat containing X-linked 6 LOC119868218 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] DFTTMARPW;EEEWDDDQE 2 6 1.0034 -1.6084 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.03205 A0A8I3PI97 A0A8I3PI97_CANLF Protein phosphatase 2 regulatory subunit B''alpha PPP2R3A Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EEYETLVAEESAQ;FEDYETEE;IAKLCGCPLYWKAPMFRAA;KDADLDSMFLPHE;LDSMFLPHEN;LSEKCGKL;QADLSRYNDQASSNRII;QLQSQSLTMNSLENV;YTVNRSWSGKITS 9 9.5 1.0005 -2.7759 0 9.87984 9.8767 8.01262 0 7.67659 7.89203 7.91862 0 0 11.4924 0 9.32937 0 0 A0A8I3PIA7 A0A8I3PIA7_CANLF cysteine desulfurase (EC 2.8.1.7) NFS1 Canis lupus familiaris (Dog) (Canis familiaris) [2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572] centrosome [GO:0005813]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654] cysteine desulfurase activity [GO:0031071]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170] AEGFQVTYLPV;RLREMSPLWEMVQ;VLDAMLPYLVNYYGN 3 8.5 1.003 -0.7558 0 0 0 0 0 9.00135 0 0 7.766 0 0 11.5361 0 0 9.75467 A0A8I3PIB8 A0A8I3PIB8_CANLF Rho GTPase activating protein 20 LOC119864445 Canis lupus familiaris (Dog) (Canis familiaris) regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] GTPase activator activity [GO:0005096] DYWCEERDCRWEG;EVTEEEKINAAQ 2 2.3 0.99077 -0.269 0 0 0 9.47306 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PIB9 A0A8I3PIB9_CANLF Microsomal glutathione S-transferase 2 MGST2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSACQQSYF 1 11.7 1.0034 -0.80421 0 0 9.7203 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PIC6 A0A8I3PIC6_CANLF Armadillo repeat-containing domain-containing protein GPRASP3 Canis lupus familiaris (Dog) (Canis familiaris) learning or memory [GO:0007611]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of synapse assembly [GO:0051965] protein homodimerization activity [GO:0042803] AMKAKSRNKIVTERRERAL;IELHVKHMCKETMSFPLNSP;LNSPGQQSGLRILG;QQSGLRILGQLTTDFDHH 4 10.5 0.99655 -0.095015 10.4405 11.0662 8.63749 0 0 0 10.4689 10.4613 6.19363 0 0 8.29788 0 0 8.96737 A0A8I3PID2 A0A8I3PID2_CANLF BTB domain containing 6 BTBD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GGGPGRPT;IHIPDVEP;PRPRPRPREPEP;RPPRPHAAAPGLPARPGGAVPHG;RSNQWRYRGRCDSIQ 5 8.3 0.98911 -0.2652 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1085 10.0208 A0A8I3PIF6 A0A8I3PIF6_CANLF SHC adaptor protein 3 SHC3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] phosphotyrosine residue binding [GO:0001784]; receptor tyrosine kinase binding [GO:0030971] CHILECCDGLAQD;SLDEPWTEEEGDGS;SLTISTASLNLRTPDSK 3 7.7 0.94319 0.088541 0 0 11.0316 9.82193 0 10.1158 10.566 0 10.7458 11.3098 11.22 0 10.1567 11.0604 10.9042 A0A8I3PIF7 A0A8I3PIF7_CANLF Integrator complex subunit 9 INTS9 Canis lupus familiaris (Dog) (Canis familiaris) snRNA processing [GO:0016180] integrator complex [GO:0032039] HFMELWGKSSLNTVIFTEPDFSYL;LSGHPTLPCNVLKF;QIEEDSTHIICD;SSGYALGSSNWIIQSHYE;VILISNYHCMMAL;VLRVRLRDLVLKFLQKF 6 15.4 1.0028 -0.71878 0 0 0 0 4.08057 0 9.35407 0 0 0 0 8.75535 0 10.423 0 A0A8I3PII7 A0A8I3PII7_CANLF Proteasome subunit beta PSMB4 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex, beta-subunit complex [GO:0019774]" VLSQTEARELVE;VLSQTEARELVERCMRVLY 2 7.2 0.98506 -0.25914 0 0 0 11.4381 0 0 0 0 0 0 0 12.4949 0 0 0 A0A8I3PIJ0 A0A8I3PIJ0_CANLF Uncharacterized protein RNF17 Canis lupus familiaris (Dog) (Canis familiaris) spermatid development [GO:0007286] cytoplasm [GO:0005737] identical protein binding [GO:0042802] EVEIHIMELPENP;KYLIKKGLALRERRIKK;LDHGFTEKIPQC;SDTDDSGVSWESESESL;SDVHLEAEDFQP 5 4.4 1.0009 -0.63135 11.6831 0 0 0 0 0 0 8.82257 5.14918 0 0 0 0 0 0 A0A8I3PIJ4 A0A8I3PIJ4_CANLF Transmembrane 9 superfamily member TM9SF4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular monoatomic cation homeostasis [GO:0030003]; protein localization to membrane [GO:0072657] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] FSDYRWWWRN;GVVFGICFVLNCF;YSLPFCQPSKIT 3 5.8 0.99347 -0.074363 11.0701 0 0 0 7.50446 0 0 0 0 0 0 0 11.9556 0 0 A0A8I3PIJ7 A0A8I3PIJ7_CANLF "DNA polymerase gamma 2, accessory subunit" POLG2 Canis lupus familiaris (Dog) (Canis familiaris) EQLYSKLCFRRE;FRLVSAETLREIL;LTENSFTR 3 7.2 1.0025 -0.80028 0 0 0 0 9.10876 0 0 0 0 0 0 0 9.32308 0 0 A0A8I3PIK4 A0A8I3PIK4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LGPLETTDTWALCL 1 18.2 0.93736 0.063716 0 0 0 0 0 0 0 9.13753 0 0 0 0 0 0 0 A0A8I3PIK8 A0A8I3PIK8_CANLF Alpha-2-HS-glycoprotein (Fetuin-A) AHSG Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; negative regulation of bone mineralization [GO:0030502]; ossification [GO:0001503]; positive regulation of phagocytosis [GO:0050766]; regulation of inflammatory response [GO:0050727] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] cysteine-type endopeptidase inhibitor activity [GO:0004869] AGPVVHPCPG;DPGVTVPEASPDLPAAAL;GVTVPEASPDLPAAAL;LVVGPVVVAIPEAPLPEH;LVVGPVVVAIPEAPLPEHRAHYDL;PETEQAAL;PETEQAALVAVDYINNHVLRG;PGVTVPEASPD;PGVTVPEASPDL;PGVTVPEASPDLPA;PGVTVPEASPDLPAA;PGVTVPEASPDLPAAA;PGVTVPEASPDLPAAAL;PGVTVPEASPDLPAAALVVG;PGVTVPEASPDLPAAALVVGP;PVGPALVYR;PVGPALVYRE;PVGPALVYREL;PVGPALVYRELD;PVVVAIPEAPLPEH;PVVVAIPEAPLPEHRAHYDL;SASGEAFHVG;SVESASGEAFHVG;VAVDYINNH;VAVDYINNHVL;VAVDYINNHVLRG;VESASGEAFHVG;VGPALVYRELD;VPVGPALV;VPVGPALVYR;VPVGPALVYRE;VPVGPALVYREL;VPVGPALVYRELD;VPVGPALVYRELDCDDPE;VTVPEASPDLPA;VTVPEASPDLPAA;VTVPEASPDLPAAA;VTVPEASPDLPAAAL;VVGPVVVA;VVGPVVVAIPE;VVGPVVVAIPEA;VVGPVVVAIPEAPLPE;VVGPVVVAIPEAPLPEH;VVGPVVVAIPEAPLPEHR;VVGPVVVAIPEAPLPEHRA;VVGPVVVAIPEAPLPEHRAHYDL;VVVAIPEA;VVVAIPEAPL;VVVAIPEAPLPE;VVVAIPEAPLPEH;VVVAIPEAPLPEHR;VVVAIPEAPLPEHRA;VVVAIPEAPLPEHRAHYD;VVVAIPEAPLPEHRAHYDL 54 27.7 0 118.66 16.2238 16.5881 16.6486 14.9332 14.8032 14.817 17.1108 16.8041 16.9284 15.9641 16.1061 16.1012 15.4362 16.1417 16.1501 A0A8I3PIL7 A0A8I3PIL7_CANLF Gamma-glutamylaminecyclotransferase (EC 4.3.2.8) GGACT Canis lupus familiaris (Dog) (Canis familiaris) cellular modified amino acid catabolic process [GO:0042219] gamma-glutamylaminecyclotransferase activity [GO:0061929] LVIAGEHNIP 1 6.1 0.99184 -0.27072 0 0 0 0 0 0 0 0 0 0 0 0 0 9.35933 0 A0A8I3PIL9 A0A8I3PIL9_CANLF Uncharacterized protein CETN4 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; ciliary basal body [GO:0036064] calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; heterotrimeric G-protein binding [GO:0032795] TQKQEIKEAFDLF 1 7.7 0.93928 0.059826 0 8.27729 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PIM0 A0A8I3PIM0_CANLF SPRY domain containing 3 SPRYD3 Canis lupus familiaris (Dog) (Canis familiaris) EEEEEEEEEDGEEIEQEHEG;ILDSEGDSDDSCDT;LVFVWCGLDPGWRQQE;PGWLPDSV;QEGEEEEEEEEEEEDGEEIEQEH 5 14.6 0.96455 0.049233 0 0 0 0 10.1714 0 0 0 0 0 0 0 0 0 0 A0A8I3PIM8 A0A8I3PIM8_CANLF Protein phosphatase 1 regulatory subunit 9A PPP1R9A Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DENNYYQPDMEYSE;DEQEDSDENNYYQPDMEYSE;GTEQDEQEDSDENNYYQPD;HEILGTGEYATDEEED;LDDGQSPKHSQCQN;NDDFSPSSTSSAD;VELEKDEDG;VGSEAAMHQKKELAGG;YDGPSYSKFTETRKMFE 9 8.1 0.9635 0.049233 0 0 0 0 0 0 0 0 0 0 0 8.10696 0 0 0 A0A8I3PIP8 A0A8I3PIP8_CANLF NFE2 like bZIP transcription factor 2 NFE2L2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EVFDFSQRRK 1 7.4 0.98851 -0.26445 0 0 0 0 0 0 0 0 12.723 0 0 0 0 0 0 A0A8I3PIR3 A0A8I3PIR3_CANLF RD3 like RD3L Canis lupus familiaris (Dog) (Canis familiaris) ELKWHLKERERLI;SDVVTKTLLRELKWHLK;TEQRQLEVLCSQIQPCQTGTILS 3 23.2 0.98758 -0.40064 0 0 9.95226 0 0 0 0 0 0 0 0 0 6.18923 9.02034 0 A0A8I3PIR7 A0A8I3PIR7_CANLF Myosin IH MYO1H Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] GVERLIKYIGYT;GVSTSSLS;NQPFANSRIDEGDINP;SINDKNDW 4 4.2 1.0033 -1.5148 0 0 0 0 0 0 8.09466 0 7.19771 0 0 0 0 8.85449 0 A0A8I3PIS3 A0A8I3PIS3_CANLF WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) SMU1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; precatalytic spliceosome [GO:0071011] HGLKSGKTLKEFRGHSS;LSRHIKFGQ;SLLRQTDPMIML;TVSLNTVDSIESFVADI;VHEKDVIGIAHHPHQ 5 14 0.99139 -0.27237 5.23389 8.57588 0 8.25238 9.82228 0 0 11.0806 0 7.98265 0 0 9.59787 0 9.54649 A0A8I3PIT6 A0A8I3PIT6_CANLF Lipid-binding serum glycoprotein N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] NALTQGLLGMNVLSTLQTI 1 9 0.98411 -0.24277 0 0 0 10.0511 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PIU2 A0A8I3PIU2_CANLF UDP-glucuronosyltransferase (EC 2.4.1.17) UGT1A6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] UDP-glycosyltransferase activity [GO:0008194] EVASEILQKAVTPYDLYS;GVPMVMLPLFGDQMDNAKR;SILSDVMSFRERVRN;YCHYLEEATQC 4 11.9 0.98819 -0.47634 0 0 0 0 0 7.97062 0 6.63615 0 0 0 0 0 0 0 A0A8I3PIU9 A0A8I3PIU9_CANLF SIX homeobox 6 SIX6 Canis lupus familiaris (Dog) (Canis familiaris) eye development [GO:0001654] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IVAFHGGNYREL;RLQQQVLSQGSGRALRAEEE 2 13 0.98667 -0.23457 0 0 8.30529 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PIW4 A0A8I3PIW4_CANLF Ciliary microtubule inner protein 2A CIMIP2A Canis lupus familiaris (Dog) (Canis familiaris) axonemal A tubule inner sheath [GO:0160111]; ciliary basal body [GO:0036064] LIQRKAISGYAG 1 3.9 0.98326 -0.25621 0 0 0 0 0 0 0 0 0 0 7.926 0 0 0 0 A0A8I3PIW6 A0A8I3PIW6_CANLF Proline and glutamate rich with coiled coil 1 PERCC1 Canis lupus familiaris (Dog) (Canis familiaris) digestive tract morphogenesis [GO:0048546]; enteroendocrine cell differentiation [GO:0035883] AVETGPELPGGGAPA;DEDEEEEDEEEDEEQPQ;EDEDEEEE;EDEEEDEEQPQAEG;EPQGPSEDEDEDEEEEDEEED;EPQGPSEDEDEDEEEEDEEEDEEQ;GPSEDEDEDEEEEDEEEDEE;GVIRPLCDFQ;PLQLLRFS;PSEDEDEDEEEEDEEED 10 24 1.003 -0.86061 7.41532 7.98254 10.2634 0 3.78409 0 6.21099 0 5.16346 0 9.98613 0 0 7.82362 6.85425 A0A8I3PIX9 A0A8I3PIX9_CANLF Somatostatin receptor 5 SSTR5 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucocorticoid stimulus [GO:0071385]; positive regulation of cytokinesis [GO:0032467]; regulation of insulin secretion [GO:0050796] neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] AEDAEATEPQPDKSS 1 4.1 0.94882 0.053908 0 0 0 18.7834 0 0 0 19.9533 0 0 9.46426 10.0539 13.5285 9.54682 0 A0A8I3PIY0 A0A8I3PIY0_CANLF Uncharacterized protein LOC102155967 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DVFLFECSEL;EIFFYWHSNH;GVSMGAHIIST;NLIDVFLFECSELRECSLVKSFIT;YTMNGSEM 5 22.4 1.003 -1.9537 0 0 0 0 0 2.72683 0 9.86106 0 9.69066 6.97602 9.22516 0 0 0 A0A8I3PJ01 A0A8I3PJ01_CANLF "Sodium leak channel, non-selective" NALCN Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]" plasma membrane [GO:0005886] voltage-gated sodium channel activity [GO:0005248] INRHANFSSAGK;LFFLLLYGILG;PTFRVKFLLRLL;QEEELRENHPYFDK;VGPMHGIYIHVFVFLGCM;VGREHRFRNFCR;VLRCLRPL 7 4.9 1.0017 -1.8145 9.14552 0 8.50827 5.87189 0 8.1396 0 0 0 0 0 7.27128 0 0 0 A0A8I3PJ05 A0A8I3PJ05_CANLF Relaxin family peptide receptor 2 RXFP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] CDGVDDCGNGADEDNCGDTS;KQLLHKHRRKSI;PDKVFTKYT;PVFVIKILSLFRV;SFEDLLANNIL;VDDCGNGADEDNC 6 9.2 0.85036 0.17046 9.46708 5.78133 0 0 0 6.52144 5.00648 0 0 0 0 6.09635 0 4.88733 0 A0A8I3PJ08 A0A8I3PJ08_CANLF Corticotropin releasing hormone receptor 1 CRHR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GRRPQLRLVKALLLLGL;HLPGGPPGGLCPLS;LVQVGDSCLQLLPRDQLLL 3 32.5 0.91566 0.11063 0 0 8.14246 0 0 0 0 0 9.7362 0 0 0 0 0 0 A0A8I3PJ15 A0A8I3PJ15_CANLF RING finger protein 207 RNF207 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628] perinuclear region of cytoplasm [GO:0048471] Hsp70 protein binding [GO:0030544]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270] EPRGNSRTLNSLTE;RLACPLCQHQT;VGKTLGSLVQK 3 5.7 0.98727 -0.49816 0 0 0 0 0 0 8.88255 4.08066 3.9314 0 0 0 9.54568 0 0 A0A8I3PJ18 A0A8I3PJ18_CANLF Solute carrier family 10 member 6 SLC10A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] GVLLLVVAVAGVVLAK;KIILKIGAIVGGVLLLVVAVAGV;SEEELPVGPEVQGNL 3 11.1 0.85281 0.14939 0 0 6.08837 0 0 0 0 0 0 0 0 0 0 8.66078 7.21442 A0A8I3PJ33 A0A8I3PJ33_CANLF LIM zinc-binding domain-containing protein ZNF185 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EQLVELDSQASSILAGS;RVEVVDEDRPSEKSQDPPAL 2 8 0.93642 0.097688 0 0 7.30816 0 0 0 0 0 0 0 0 8.33047 0 0 0 A0A8I3PJ42 A0A8I3PJ42_CANLF Centrosomal protein 170B CEP170B Canis lupus familiaris (Dog) (Canis familiaris) EDPAAKAAAAVVAG;PGAGTQEGKPALTPPSPQG;TGGSSGPQ;VAILAREIHDVAG 4 3.3 0.9914 -0.27741 0 0 0 0 0 0 0 0 0 0 0 0 0 12.8649 0 A0A8I3PJ52 A0A8I3PJ52_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] AGSCCAGN;AGSCCAGNCCA;AGSCCVRSCCASCCAWSCCAWSCC;ASCCAWSCCAWSCCAGNCCAGNCW;ASCCGWSCCAWSC;ASCCGWSCCAWSCCAGSC;CAGSCCAGNCCARSCCAG;CASCCAWSCCAWSCCAGN;CAWSCCAGSCCAG;CCAGNCCA;CCAGNCCARSCCAGTY;CCARSCYASCCGWSCCAWSCCAGSC;CCASCCAWSCCAWSCCA;CCASCCAWSCCAWSCCAGNCCA;CCASCCAWSCCAWSCCAGNCCAG;CCAWSCCAGN;CCAWSCCAGNCCAGN;CCAWSCCAGSCC;CCAWSCCAGSCCAGNC;CCAWSCCAWSCCAGNCC;PSCCAWSCCAWSCCA;RSCYASCCGWSCCAWSCCAGSC;SCCAGSCCA;SCCASCCA;SCCASCCAWSCCAWSCCAG;SCCAWSCCAGSCCAGN;SCCAWSCCAGSCCAGNC;SCCAWSCCAGSCCAGNCCARSCCA;SCCAWSCCAGSCCVRSCCASCC;SCCGWSCCAWSC;SCYASCCGWSCCAWSCCAGSC 31 66.2 0.99695 -4.1815 7.1151 6.37773 9.9911 10.5981 7.5809 10.6375 6.05905 6.62275 7.62556 8.82302 7.99061 6.56207 6.67976 8.51971 6.85711 A0A8I3PJ53 A0A8I3PJ53_CANLF Microtubule associated scaffold protein 2 MTUS2 Canis lupus familiaris (Dog) (Canis familiaris) AADLKKASGSNAAKSN;DGHVSFIPYDLPDS;DTNANQIMLEVSS;ERASSSAVVAGSL;GVENHQVEKVEERTE;LANIRDEVAFNTAKCEKLQKEK;LSNESTSHSAHPEPGL;PSVGENSPGVPEPLG;QEVTERPGK;QTPRSVQGPS;RLQPAPLDSPEALRPEPSGREGPQ;SCYAQLRDNRNGV 12 13.1 1.0025 -1.1324 8.78771 12.1177 0 9.07288 0 0 8.3881 9.14845 13.0899 0 10.1463 0 10.3258 10.0374 0 A0A8I3PJ54 A0A8I3PJ54_CANLF Cyclin-L1 CCNL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nuclear speck [GO:0016607] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] RHHNHGSPHLKAKHTRDD 1 3.6 0.97392 0.048313 0 0 0 4.98149 0 0 0 0 0 0 0 0 5.39318 0 0 A0A8I3PJ55 A0A8I3PJ55_CANLF MBL associated serine protease 1 MASP1 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, lectin pathway [GO:0001867]; proteolysis [GO:0006508]" extracellular space [GO:0005615] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ADCGAPAE;CDHYCHNYIGGYYCSCRFG;ESPVLNDFVMPI;LRPSDFKVIMG;PEGFRIKLYFMHF;TFCGRETTDTEQ;VETEEQVLAT;VYTQRTGVITSP 8 13.7 0.93721 0.071339 0 0 0 0 0 0 0 9.52785 0 0 0 0 0 0 0 A0A8I3PJ60 A0A8I3PJ60_CANLF SET domain bifurcated histone lysine methyltransferase 1 SETDB1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; protein-lysine N-methyltransferase activity [GO:0016279]; zinc ion binding [GO:0008270] APPVPPLSPQAGDNDSL;CLDPYVLVDR;DSSDDNFCKDEDFS;EDFSTSSVWRSYATR;EDPEESNDDSSDD;GKILTDDFADKEGL;LVRILFLDDKRCEWIYRG;NDDSSDDNFCKDEDFSTS;VNEIDTTPPP;YSKLGLQYRDSS 10 8.8 1.0032 -1.5931 5.50814 10.7169 9.49061 0 0 0 4.01739 8.58875 0 0 10.2184 12.1647 5.7574 0 0 A0A8I3PJ67 A0A8I3PJ67_CANLF PHD finger protein 11 SETDB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DGAPWTRRWPGHPT;EDGRHTDATVKIDFL;LSAAFHPQD;QLKEELEALQDLN 4 15.4 1.003 -1.6319 0 0 9.14555 0 0 0 11.3611 0 0 7.98168 8.91594 0 8.80629 0 8.46923 A0A8I3PJ68 A0A8I3PJ68_CANLF Transmembrane protein 59 like TMEM59L Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] CMSRAPSLDPGLLPLPFC 1 4.2 0.98364 -0.25538 0 0 0 0 0 0 0 0 0 0 0 0 0 8.80758 0 A0A8I3PJ89 A0A8I3PJ89_CANLF BTB domain containing 18 BTBD18 Canis lupus familiaris (Dog) (Canis familiaris) male meiosis I [GO:0007141]; piRNA transcription [GO:0140541]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DLEITSSQPLDGQR;GEAVPAHCCIL;LDFMLCGS;VLSVGGSWTPDLEIT 4 5.9 0.99185 0.010998 0 0 14.2186 0 8.77732 0 0 4.66914 0 0 0 13.2994 0 9.04286 7.91755 A0A8I3PJ93 A0A8I3PJ93_CANLF Spermatid maturation 1 SPEM1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291] cytoplasm [GO:0005737]; membrane [GO:0016020] QDAVEPAP;SPQTLSHKNSGAGP 2 7.1 0.98636 -0.42378 7.36999 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PJB3 A0A8I3PJB3_CANLF Transient receptor potential cation channel subfamily C member 3 TRPC3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] cation channel complex [GO:0034703]; plasma membrane [GO:0005886] "inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]" EEEEEEEEEEEEGEDGGSEPQ;EEEEEEEEEEEEGEDGGSEPQRR;EIKQDISSLRYELLED;EVVHMLLMKGA;PEEEEEEEEEEEEEEGEDGGS;PVLTALEL;VLTALELSN 7 7.2 1.0015 -1.809 0 7.27006 0 0 0 0 7.87633 9.07874 0 0 0 0 0 6.72806 0 A0A8I3PJB5 A0A8I3PJB5_CANLF Cellular tumor antigen p53 TP63 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262] centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" STELKKLY;TDCSLVRIW 2 3.1 0.98572 -0.24599 0 0 0 0 0 0 0 0 9.72627 0 0 0 0 0 0 A0A8I3PJC6 A0A8I3PJC6_CANLF BPI fold-containing family A member 1 (Palate lung and nasal epithelium clone protein) BPIFA1 Canis lupus familiaris (Dog) (Canis familiaris) antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to virus [GO:0051607]; immune response in nasopharyngeal-associated lymphoid tissue [GO:0002395]; innate immune response [GO:0045087]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of single-species biofilm formation in or on host organism [GO:1900229]; regulation of sodium ion transmembrane transport [GO:1902305]; surfactant homeostasis [GO:0043129] extracellular space [GO:0005615] lipid binding [GO:0008289] ALSLPLEHTLFL;FLEVTPGQDPSPTD;LILGDCTHSPG;LVQGEVSGGGGQGVAAPDLWVS 4 17.9 0.99053 -0.21023 0 8.70207 0 0 7.68426 0 0 0 12.6369 0 0 8.26214 0 0 0 A0A8I3PJD2 A0A8I3PJD2_CANLF TBC1 domain family member 17 TBC1D17 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] LLNDILLTYCMYHFDLGY;PLCDFLDSQDSGS 2 5 0.92416 0.10814 0 0 0 0 0 0 7.7185 0 0 7.34234 0 0 0 0 0 A0A8I3PJD6 A0A8I3PJD6_CANLF Rho GTPase activating protein 24 ARHGAP24 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AERAKEDAEKRN;GVSNNNNEIQKKAT;LAPMLVEQCVDF;VQSYSGVN;YLRELPEPVIPYAKY 5 9.3 0.98678 -0.45859 0 0 0 0 0 4.45187 6.69725 0 0 0 0 7.99588 0 0 7.97854 A0A8I3PJD8 A0A8I3PJD8_CANLF Endoplasmic reticulum-Golgi intermediate compartment protein ERGIC3 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] DPDSLNPDRCESCYGAETEDIKCCN;EDIKCCNTCE;PTVYMKVDGEVLRTNQFSV 3 12.3 1.003 -0.86006 0 0 0 0 0 0 0 5.2282 6.56438 0 0 0 0 0 8.9453 A0A8I3PJE7 A0A8I3PJE7_CANLF Tubulin tyrosine ligase like 10 TTLL10 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] AALQVKAQSIEDDPIYR;AGVRQSHPRGPGWAHERPMGSIQ;LHSLSQLGQ;LIDENFKVWLL;RLDIRDDREAFFTLFDENQIWICK;VNLRVPFV 6 11.2 0.98489 -0.23782 0 0 13.6818 0 0 0 7.92089 0 0 0 0 0 0 0 6.15981 A0A8I3PJF0 A0A8I3PJF0_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT13 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] CNDSPLQK;EDRKTVVCPIIDVISDDTFEY;KTVVCPIIDVISDDTFE;LENIYPDSQIPRRYYSLGEIRNVET;SWYLENIYPDSQ;SWYLENIYPDSQIPRRYYSL;VISDDTFEYMAGSDMTYGG;VISRNQEGPGEMG;YTRMEVFR 9 15.7 1.0032 -1.9232 5.78196 8.85751 6.59069 0 0 0 10.1214 0 10.9459 0 0 0 0 11.8079 9.11494 A0A8I3PJF7 A0A8I3PJF7_CANLF "Raftlin, lipid raft linker 1" RFTN1 Canis lupus familiaris (Dog) (Canis familiaris) B cell receptor signaling pathway [GO:0050853]; dsRNA transport [GO:0033227]; membrane raft assembly [GO:0001765]; positive regulation of growth rate [GO:0040010]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138] endosome [GO:0005768]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] double-stranded RNA binding [GO:0003725] GVEGARGP;QLLELYQQGFSLV;SLHSLTDGVFIFEAVST;TPIAEQPSLSS;TPIAEQPSLSSG 5 7.2 1.003 -0.86358 11.9919 0 12.0989 11.1468 12.009 12.0654 11.7392 11.7565 12.0989 0 12.3144 12.208 11.6805 11.3747 11.5336 A0A8I3PJG2 A0A8I3PJG2_CANLF Oxysterol-binding protein OSBPL10 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] cytoplasm [GO:0005737] lipid binding [GO:0008289] AGLGGGGS;FMGMSVGVSMIGEGV;GVSSRSAAAGLGGG;IVSLSDEAPHMLV;LLEMYADFMAHPDLL;VEGQQKNLVHAIESL 6 10.6 1.0025 -1.3567 0 0 9.77418 0 8.07103 0 0 0 0 0 9.24391 9.26073 0 0 9.50398 A0A8I3PJG3 A0A8I3PJG3_CANLF HTH CENPB-type domain-containing protein LOC102155295 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] NLAFRILLILDN;TDEKFAGKAGP;TEVLFMPPNTASLIQP 3 11.5 0.99438 -0.12529 0 9.10436 5.59541 0 0 0 0 0 0 0 0 0 0 9.23907 0 A0A8I3PJG5 A0A8I3PJG5_CANLF Protein kinase C and casein kinase substrate in neurons 3 PACSIN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of endocytosis [GO:0045806]; plasma membrane tubulation [GO:0097320]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044] cytosol [GO:0005829]; endosome [GO:0005768]; plasma membrane [GO:0005886] calcium channel inhibitor activity [GO:0019855]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] EAGNYRRTV;GREGQSRN;LEVREKLQGQ;LVSCFQERA;QSPGSPGGGQDEEWSDEENP;RKWRGTVEKGPQ;TIPCCGDTMAPEED;VRSWQRGAFHRPVLGGF 8 17.2 1.0017 -2.6281 0 0 0 0 0 9.36768 0 9.71915 0 8.88225 0 3.78429 6.28096 0 0 A0A8I3PJG8 A0A8I3PJG8_CANLF Pejvakin PJVK Canis lupus familiaris (Dog) (Canis familiaris) detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; stereocilium maintenance [GO:0120045] ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044] AATKSFVKQ;KKKRCFLFPRY;MESIRTTRQCSLSVH 3 9.9 0.98897 -0.52244 0 0 0 0 0 0 0 0 10.4579 0 0 0 9.20823 0 0 A0A8I3PJH2 A0A8I3PJH2_CANLF Microtubule-associated protein MAPT Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175] axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; plasma membrane [GO:0005886] microtubule binding [GO:0008017] EGQATPPEFTFH;TPNLEDQAAGHVTQEI 2 4.6 0.98776 -0.22549 0 0 10.5808 0 0 0 0 0 0 0 0 0 0 6.03402 0 A0A8I3PJH6 A0A8I3PJH6_CANLF Spermatid nuclear transition protein 1 Canis lupus familiaris (Dog) (Canis familiaris) NTKRWKKRKSPSRSRSRGVL;RWKKRKSPSRSRSRGVLKIYKKVKR;VLKIYKKVKRS 3 38.2 0.91787 0.11923 6.16962 0 0 2.83988 0 0 0 0 0 5.43606 0 0 0 0 0 A0A8I3PJI8 A0A8I3PJI8_CANLF Collagen type IV alpha 2 chain COL4A2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; DNA-templated transcription [GO:0006351]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; negative regulation of angiogenesis [GO:0016525] collagen type IV trimer [GO:0005587]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] APGIFGLEG;EGGGQSLV;GAPSPPAG;GVPGLKGDDGVPGRDGLDGFP;LDGFPGLPGP;PGSPGADI;PPGPPGPAALP;PSADTLKAGL;PVAEDDIKPYISR;QTDQEPMCPVGMNKLWSGYSLLYF;WPGIPGSPGFPG 11 6.2 0.99947 -2.9165 8.88163 9.61267 0 0 0 0 0 0 0 0 8.29834 8.91477 0 9.48519 10.5422 A0A8I3PJJ5 A0A8I3PJJ5_CANLF FAT atypical cadherin 3 FAT3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] catenin complex [GO:0016342] cadherin binding [GO:0045296]; calcium ion binding [GO:0005509] AESTPLRTSVAQVTATDA;AVVLLVILVLVVLFVVFRKK;AVVLLVILVLVVLFVVFRKKV;EELIGIAVVLLVIL;EGANGEIESISIVAGDPLDQ;ELIGIAVVLLVILVL;ELIGIAVVLLVILVLVVLFVV;ELIGIAVVLLVILVLVVLFVVFR;IAVVLLVILVLVVLFVVFRKKVFR;IDPKTGMVSSRKQFTAGSYDILTI;IVDGNDDGKFFIDPKTG;KQSTIWVVVQ;KVKKKLDRERVSGY;KVLLPMDREHT;LDHEVSPAFH;LILLLLKLLATVSQGLP;LSNIEYGVTVL;LVHEMLQNTVTI;LVILVLVVLFVVFRKKV;LVILVLVVLFVVFRKKVF;LVILVLVVLFVVFRKKVFRKNY;MEAFNIDSNTGWI;NCSGLDCQEQHCEQGLS;QVRAIDMDWGA;SEVNVTIRIGNVNDNSPLFEK;SIDSVSMRKFRI;SSDVSASCGFDDSE;TASINEDIRMDTPI;VEQLVHEML;VGELSLASLHIPF;VGKEELIGIAVVLLVILVLVVLFVV;VGPPAACEFSTFAVSLN;VIQIQAEDPD;VLLVILVLVVLFVVFRKK;VLLVILVLVVLFVVFRKKVFRK;VSLSLHNSRGTSSS 36 7.7 1.0036 -2.2446 12.0026 7.08012 11.7675 8.61802 9.59115 8.09566 15.5904 12.1509 10.9864 8.6436 0 7.75074 10.3676 11.1271 6.52132 A0A8I3PJJ6 A0A8I3PJJ6_CANLF Tripartite motif containing 13 TRIM13 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] ETPLPPSNLPTSPLMKNFDT 1 5.3 0.98378 -0.24771 9.84975 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PJK3 A0A8I3PJK3_CANLF Rab proteins geranylgeranyltransferase component A CHM Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; small GTPase-mediated signal transduction [GO:0007264] Rab-protein geranylgeranyltransferase complex [GO:0005968] GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096] DLEPVVQKLFTPYT;LVEDSYFSEN;SEEETSKNVPT 3 5.5 0.99792 -0.089412 0 0 0 0 0 0 0 0 11.6858 0 0 0 0 9.99294 0 A0A8I3PJK4 A0A8I3PJK4_CANLF "Interacts with SUPT6H, CTD assembly factor 1" IWS1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleoplasm [GO:0005654] EEEFTGFNQEDL;ELQRQKDSD;ESDDDSDG;ESEEPQQHQASD;PKSPASDSETED;PQKGPASDSE;SRPGILKKGLSRLEKHKRRFAE 7 10 0.97297 0.046699 0 0 6.05981 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PJL0 A0A8I3PJL0_CANLF TBCC domain-containing protein 1 TBCCD1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle pole [GO:0000922] NYWDNPMIV;WNDYSHQAFVCDHL 2 5 0.98835 -0.4766 0 9.97341 0 0 0 0 0 0 3.69187 0 0 0 9.39322 0 4.9479 A0A8I3PJL4 A0A8I3PJL4_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) LOC119869187 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783] cysteine-type deubiquitinase activity [GO:0004843] AGDVAKLPH;AGDVAKLPHV;AYHCSKCLEKVP;LDLQHYLSEQR;LVYVLYAVLV;VAGDVAKLPH 6 8.1 1.0041 -1.0844 0 0 8.80558 0 9.58015 0 0 0 0 0 0 0 0 0 0 A0A8I3PJL6 A0A8I3PJL6_CANLF Nuclear receptor coactivator NCOA3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to estradiol stimulus [GO:0071392]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] disordered domain specific binding [GO:0097718]; histone acetyltransferase activity [GO:0004402]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; protein dimerization activity [GO:0046983] DLLGPPSNLDGQSDERALLDQLH;DVQKADVSSTGQGVID;EAYIHGHAETPVYRFS;GVHSPMGSS;GVLPLTFLRVF;NLQGQSPSFNSMMNQMNQQGNFP;NPESFITRHDLSGKVV;NSLDDLLGPPS;SLDSPVSVGSSPPVKN;TSVYSILHEEDRKD;VGSSPPVK;VTQYLQYKQEDLVN;VVNIDTNSLRSSMR 13 12.1 1.0031 -2.2877 0 11.9018 12.1541 0 8.95829 0 0 8.86824 11.0774 0 6.2704 0 8.6894 9.96242 12.0117 A0A8I3PJM0 A0A8I3PJM0_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) CTDNEP1 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; gamete generation [GO:0007276]; mesoderm development [GO:0007498]; nuclear envelope organization [GO:0006998]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein localization to nucleus [GO:0034504] endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear membrane [GO:0031965] protein serine/threonine phosphatase activity [GO:0004722] ADKLDNSRSILKRR;VLSRNLHQHRL 2 10.2 0.66148 0.31204 10.147 0 0 0 0 0 0 0 0 0 0 0 8.64533 9.03185 0 A0A8I3PJM2 A0A8I3PJM2_CANLF Lysophosphatidic acid receptor 4 LPAR4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Rho protein signal transduction [GO:0035025] nuclear body [GO:0016604]; plasma membrane [GO:0005886] lysophosphatidic acid binding [GO:0035727]; lysophosphatidic acid receptor activity [GO:0070915] IVDDSFKYNL;KISGTAFLTNIYGSML 2 7 0.98214 -0.24855 7.68755 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PJN5 A0A8I3PJN5_CANLF Ig-like domain-containing protein IGHE Canis lupus familiaris (Dog) (Canis familiaris) DLSVFPLASCCKDNIAST;SVTLGCLV 2 6.5 1.0033 -1.3355 0 0 0 7.61868 0 0 0 0 0 0 0 0 0 9.48718 9.46404 A0A8I3PJP7 A0A8I3PJP7_CANLF Tumor protein 63 (p63) TP63 Canis lupus familiaris (Dog) (Canis familiaris) cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; cranial skeletal system development [GO:1904888]; determination of adult lifespan [GO:0008340]; ectoderm and mesoderm interaction [GO:0007499]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of stem cell proliferation [GO:2000648]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein tetramerization [GO:0051262]; proximal/distal pattern formation [GO:0009954]; regulation of epidermal cell division [GO:0010482]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; stem cell proliferation [GO:0072089]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366] centrosome [GO:0005813]; chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654] "damaged DNA binding [GO:0003684]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; metal ion binding [GO:0046872]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; WW domain binding [GO:0050699]" DEWNDFNFDMDAR;FDMDARRNKQQ;STELKKLY 3 3.8 0.99303 -0.16671 8.8889 0 0 0 0 0 0 0 9.74477 0 0 10.2583 5.61636 0 0 A0A8I3PJQ1 A0A8I3PJQ1_CANLF Extended synaptotagmin 3 ESYT3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum-plasma membrane tethering [GO:0061817]; lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] lipid binding [GO:0008289] DLQICYIGDCEIS;ELASRTVDPHWEVL;LDAPGINEISDSL;LGEFISGTPCRNSD 4 6.1 0.99704 -0.087548 0 0 0 0 12.1074 0 0 0 10.5642 0 0 0 0 0 10.2495 A0A8I3PJR3 A0A8I3PJR3_CANLF Nuclear nucleic acid-binding protein C1D C1D Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460] cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053] DNA binding [GO:0003677]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714] KLDPLEQAKVDLV 1 9.2 0.93639 0.072359 0 0 0 0 0 9.46871 0 0 0 0 0 0 0 0 7.60452 A0A8I3PJR7 A0A8I3PJR7_CANLF Pseudouridine 5'-phosphatase PUDP Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine 5'-phosphatase activity [GO:1990738] EAALEAGM 1 3.5 1.004 -1.1044 0 0 0 0 0 0 10.5984 0 0 0 0 0 0 0 0 A0A8I3PJS6 A0A8I3PJS6_CANLF Keratin 18 KRT18 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] EVKGLQNQIANSGLTVE;GGWGSGGLAAGMAGGLAGIGG;NQIANSGLTVELDAPK;NSLREVETRYAMQMEQL;YDELAQKNREELDKYWSQ 5 19.9 0.93736 0.073 0 0 0 0 0 0 9.31481 10.5908 0 7.47743 0 0 5.39951 6.18497 0 A0A8I3PJU0 A0A8I3PJU0_CANLF "Abhydrolase domain containing 6, acylglycerol lipase" ABHD6 Canis lupus familiaris (Dog) (Canis familiaris) long-term synaptic depression [GO:0060292]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178] AMPA glutamate receptor complex [GO:0032281]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; postsynaptic membrane [GO:0045211] acylglycerol lipase activity [GO:0047372]; phospholipase activity [GO:0004620] PSILMLHG 1 2.4 0.99023 -0.20517 0 0 0 0 0 0 6.12137 0 0 0 0 0 0 9.64575 0 A0A8I3PJU2 A0A8I3PJU2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGLQAEDEADYYCSSYDSS;FTGSWAQSALTQ 2 22.5 0.99442 -0.18948 0 0 0 0 0 0 7.27975 0 0 0 0 0 10.5248 0 0 A0A8I3PJU3 A0A8I3PJU3_CANLF Single-pass membrane and coiled-coil domain-containing protein 4 SMCO4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VVLLIVVFVYVATRP 1 25.4 0.95309 0.053888 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.93551 A0A8I3PJU4 A0A8I3PJU4_CANLF Zinc finger CHCC-type domain-containing protein NDUFS6 Canis lupus familiaris (Dog) (Canis familiaris) AASTAGYRIPAPAGA;ALVHPGAAPV;ASPTGEKITHT;DGGGGALGH;GTCGYCGL;PTARAHNESI;PTCAPRRGLD 7 12.7 0.99947 -3.0965 0 0 0 0 0 0 12.1023 0 0 0 0 0 0 10.5019 9.03535 A0A8I3PJU5 A0A8I3PJU5_CANLF Paraspeckle component 1 PSPC1 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; negative regulation of DNA-templated transcription [GO:0045892]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511] fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; paraspeckles [GO:0042382] RNA binding [GO:0003723] VSGGPGGFG 1 1.7 0.98908 -0.20318 0 0 0 0 0 0 0 11.4212 11.4556 0 0 0 0 0 0 A0A8I3PJV4 A0A8I3PJV4_CANLF Leukotriene A4 hydrolase LTA4H Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] LAAGSWGA 1 1.2 0.98957 -0.2632 0 0 8.02719 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PJW0 A0A8I3PJW0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proteasomal protein catabolic process [GO:0010498] "cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" YKYGIADISQVYTQNAEMRPLGCC 1 11.1 0.97169 0.041303 0 0 0 0 0 0 0 0 0 5.27344 0 0 0 0 0 A0A8I3PJW4 A0A8I3PJW4_CANLF Calpain 6 CAPN6 Canis lupus familiaris (Dog) (Canis familiaris) microtubule bundle formation [GO:0001578]; proteolysis [GO:0006508]; regulation of cytoskeleton organization [GO:0051493] perinuclear region of cytoplasm [GO:0048471]; spindle microtubule [GO:0005876] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; microtubule binding [GO:0008017] LVEEKYKLFG;PHLIVGNISNHQLIQ;SEVPVQLRE;WQQLTVADRKNLGLVMSDDGE;YAGIFRFRFWHFGEWTEVVIDDLL 5 12.3 1.0022 -1.8806 0 0 0 7.18903 0 0 14.8709 0 8.95989 0 0 5.60783 0 0 0 A0A8I3PJW7 A0A8I3PJW7_CANLF dTMP kinase (EC 2.7.4.9) DTYMK Canis lupus familiaris (Dog) (Canis familiaris) dTDP biosynthetic process [GO:0006233] ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798] GAGPSSCW;LFSANRWEQVSR;PGRCQPIRARL 3 5.3 1.0032 -0.87344 0 0 0 0 0 0 0 0 0 0 0 0 0 11.6105 0 A0A8I3PJW8 A0A8I3PJW8_CANLF Fatty acyl-CoA reductase (EC 1.2.1.84) FAR1 Canis lupus familiaris (Dog) (Canis familiaris) long-chain fatty-acyl-CoA metabolic process [GO:0035336] peroxisomal membrane [GO:0005778] alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019] AGQTPQERVEEVI;ENLRDAVQLNV;NPFHWGEVEYHVIS;RLHKAMVF;SLGLKNVRMCWF 5 10.7 0.94352 0.05044 0 0 0 0 0 0 0 0 0 0 9.13265 0 0 0 0 A0A8I3PJX4 A0A8I3PJX4_CANLF Isopropylmalate dehydrogenase-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrion [GO:0005739] DYLQLHSYATS 1 3.5 0.99075 -0.19613 0 0 0 0 0 0 0 0 0 0 9.95466 0 0 0 0 A0A8I3PJX8 A0A8I3PJX8_CANLF Eukaryotic translation initiation factor 2A (eIF-2A) EIF2A Canis lupus familiaris (Dog) (Canis familiaris) translation initiation factor activity [GO:0003743] ELWQVSWQPFLDGIFPVKTI;QEARNEKSPDLAPTPAPQSTPRNT 2 8.4 0.98623 -0.23524 0 0 0 0 9.55273 0 0 0 0 0 0 0 7.97562 0 0 A0A8I3PJY0 A0A8I3PJY0_CANLF SRY-box transcription factor 15 SOX15 Canis lupus familiaris (Dog) (Canis familiaris) myoblast development [GO:0048627]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle tissue regeneration [GO:0043403]; trophoblast giant cell differentiation [GO:0060707] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" LPGGYGSSHCKPEA 1 6 0.98332 -0.25549 0 0 0 0 0 0 0 0 0 0 10.4984 0 0 0 0 A0A8I3PJY3 A0A8I3PJY3_CANLF Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha PIP5K1A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524] DTVSVHRPGFYAERFQ;SLLMSIHNIDHAQRE;TVQHKEAEFLQKL 3 8.8 0.91869 0.11404 6.73308 0 0 0 0 0 0 10.2071 0 0 0 0 0 0 0 A0A8I3PJZ8 A0A8I3PJZ8_CANLF Acetylcholine receptor subunit beta CHRNB1 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to nicotine [GO:0035095]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941] acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; postsynaptic specialization membrane [GO:0099634] acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] EVVSSISY;SGWGRGTDEYFIR;SYDSSEVS;TKVYLDLEWTDYRL 4 8.5 1.0022 -1.8802 0 0 0 0 0 0 0 7.66924 6.75275 0 0 0 5.95924 0 0 A0A8I3PK08 A0A8I3PK08_CANLF Capping protein regulator and myosin 1 linker 1 CARMIL1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament network formation [GO:0051639]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] cytosol [GO:0005829]; filamentous actin [GO:0031941]; lamellipodium [GO:0030027]; macropinosome [GO:0044354]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] protein-containing complex binding [GO:0044877] DEPSSPKGAMRSPALDM;EEVNAIGHRKSQPTNVSR;EQGPCGGFSQMYACVCDWLG;ETLESMAGEV;IGRKIKIAVKKKVKL;IGRKIKIAVKKKVKLEVKGDKV;KIKIAVKKKVKL;KSIKDVIGRKIKIAVKKKV;NAIAHLDLS;PIHIEDPPFPSGRQ;QEQKPWSSSKDGHQGSKSSDSGEEA;RKIKIAVKKKVKLEVK;VIGRKIKIAVKKKVKL;VIGRKIKIAVKKKVKLE;VIGRKIKIAVKKKVKLEV;VIGRKIKIAVKKKVKLEVKG;VLDSLVQMIQ 17 10.3 0.99832 -0.60468 6.7237 0 0 3.85629 6.01759 3.72705 9.45354 7.27268 12.3532 0 0 10.5669 9.19059 5.09246 7.71411 A0A8I3PK15 A0A8I3PK15_CANLF F-box and leucine rich repeat protein 2 FBXL2 Canis lupus familiaris (Dog) (Canis familiaris) modulation by host of viral RNA genome replication [GO:0044830]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; protein monoubiquitination [GO:0006513]; regulation of autophagy [GO:0010506]; regulation of inflammatory response [GO:0050727]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005] phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein phosphatase binding [GO:0019903]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756] ELLLRIFSFLDI 1 2.7 0.9523 0.05044 0 8.86564 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PK16 A0A8I3PK16_CANLF Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) ZCCHC8 Canis lupus familiaris (Dog) (Canis familiaris) catalytic step 2 spliceosome [GO:0071013]; nuclear body [GO:0016604]; TRAMP complex [GO:0031499] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AEEVEERFGRFKPGVISEELQDA;DDGDEEDEHGA;ELRERLRQCE;LHVDTSPS;TLEELEEQQRRI;VPEGKPSE 6 10.2 1.0033 -2.141 0 0 10.637 0 0 8.61776 0 0 0 9.69045 0 0 7.65557 0 0 A0A8I3PK19 A0A8I3PK19_CANLF Glucose-6-phosphatase (EC 3.1.3.9) G6PC2 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; regulation of insulin secretion [GO:0050796] endoplasmic reticulum membrane [GO:0005789] glucose-6-phosphatase activity [GO:0004346] AEHLFYVLSFCKSA 1 3.9 0.98349 -0.25628 0 0 8.42177 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PK28 A0A8I3PK28_CANLF Vacuolar fusion protein MON1 homolog MON1B Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] Mon1-Ccz1 complex [GO:0035658] GAPAFAAG;PPPAPAAS 2 4 0.98962 -0.26592 10.0947 0 0 0 0 0 9.59515 0 0 0 0 0 0 0 0 A0A8I3PK29 A0A8I3PK29_CANLF E2F transcription factor 1 PXMP4 Canis lupus familiaris (Dog) (Canis familiaris) anoikis [GO:0043276]; cellular response to xenobiotic stimulus [GO:0071466]; DNA damage checkpoint signaling [GO:0000077]; DNA-templated transcription [GO:0006351]; forebrain development [GO:0030900]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lens fiber cell apoptotic process [GO:1990086]; mRNA stabilization [GO:0048255]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045] centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; Rb-E2F complex [GO:0035189] "DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PEESAGGISPGKTPSQGTAS 1 4.6 0.94876 0.055366 0 0 8.27137 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PK40 A0A8I3PK40_CANLF UBC core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] LTKGPNDSP;TIHFLTDYPFKPP 2 21.6 1.0019 -0.74201 0 0 0 9.37175 7.3906 0 0 0 0 7.72042 7.26697 0 0 0 0 A0A8I3PK46 A0A8I3PK46_CANLF DRBM domain-containing protein PRKRA Canis lupus familiaris (Dog) (Canis familiaris) regulation of regulatory ncRNA processing [GO:0070920]; siRNA processing [GO:0030422] nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] double-stranded RNA binding [GO:0003725]; siRNA binding [GO:0035197] CLAELSTSPITV;HNALQYLKI;TNVVGHSLGCTWHSLRNSPGE 3 13.9 0.85744 0.18948 0 0 0 0 0 0 0 0 0 0 0 11.7571 0 0 15.8936 A0A8I3PK51 A0A8I3PK51_CANLF Calponin-homology (CH) domain-containing protein CFAP47 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] EHITINCQVGNIT;ENSPESDCHSPN;ESSTFLSLPSQ;FGDVCVNS;FKASELYTQYCSSNSPM;HRLCKESMKDALIAFPND;IMLVATEPDVDDV;LEPEDYKKWIEITEKHY;LGVTFPKGIVI;PTYLPKKVVP;VGEELGTNIHQKT;VGLYNHQNYFAKFEWQPV;VNPCFSSSNIYSN;VPNYTKTIQ 14 6 0.9995 -0.61146 0 0 0 0 0 0 0 0 0 0 7.18418 0 0 0 0 A0A8I3PK60 A0A8I3PK60_CANLF Nuclear factor kappa B subunit 2 NFKB2 Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; non-canonical NF-kappaB signal transduction [GO:0038061]; spleen development [GO:0048536] Bcl3/NF-kappaB2 complex [GO:0033257]; cytosol [GO:0005829]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DFSPTDVHKQY;LDGMIEYDD;LKRKRGGD;PGAQGSWAELAERLGLRSLVD;SHMGGGSGGSAGGYGGAGGGGGS 5 8 1.0019 -1.2615 0 9.6264 0 0 0 0 0 8.9971 0 9.10037 0 0 0 4.53363 0 A0A8I3PK65 A0A8I3PK65_CANLF Dynein light chain Tctex-type 3 DYNLT3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleus [GO:0005634] dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802] RGARRAVAPPL;VGATMEEYHRHC 2 15.9 0.9925 -0.55387 0 0 0 0 0 0 0 11.6899 11.6973 0 0 11.4385 0 0 0 A0A8I3PK66 A0A8I3PK66_CANLF ATM interactor ATMIN Canis lupus familiaris (Dog) (Canis familiaris) APGAVHILPLSV;FESVHPSY;KLLLPKPKVALVKLPVMQF;NIQTQTEESELNTMTTEPVLE;SLPISVHTQTF;TFQCTCGCP 6 12 1.0034 -2.0789 0 8.35125 0 0 0 7.4559 0 0 0 0 0 0 12.9466 0 0 A0A8I3PK79 A0A8I3PK79_CANLF mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) GMPPB Canis lupus familiaris (Dog) (Canis familiaris) GDP-mannose biosynthetic process [GO:0009298] cytoplasm [GO:0005737] GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase (GTP) activity [GO:0004475] ALAAAGVDHVILA;YLNGASVLPHKS 2 6.9 0.99411 -0.13137 0 0 8.42211 10.5225 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PKB2 A0A8I3PKB2_CANLF Thioesterase superfamily member 5 THEM5 Canis lupus familiaris (Dog) (Canis familiaris) long-chain fatty-acyl-CoA metabolic process [GO:0035336] mitochondrial matrix [GO:0005759] long-chain fatty acyl-CoA hydrolase activity [GO:0052816] HRALFGGPQVLPRLN;SDKSDWRIFTRCIQVEG 2 13 0.93826 0.10428 0 0 0 6.65807 6.72233 3.79421 0 0 0 0 0 0 0 0 0 A0A8I3PKB4 A0A8I3PKB4_CANLF Solute carrier family 34 member 3 SLC34A3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular phosphate ion homeostasis [GO:0030643]; sodium-dependent phosphate transport [GO:0044341] apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526] sodium:phosphate symporter activity [GO:0005436] LVLIVKLLNSVLRGRVAQ;NVVLSNPVAGLVIGVLVTV;STVLAAVG;VEQLPCHHL 4 9 0.99022 -0.26592 16.219 0 0 0 0 0 12.3177 0 16.2384 0 0 1.47264 0 0 0 A0A8I3PKD3 A0A8I3PKD3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EIYCQVIKQ;FDNPTYITTHYKQVS 2 4.7 1.0019 -0.74155 0 0 0 0 0 9.09877 8.7897 0 0 0 0 0 0 0 0 A0A8I3PKD5 A0A8I3PKD5_CANLF Cilia and flagella associated protein 92 (putative) CFAP92 Canis lupus familiaris (Dog) (Canis familiaris) DKPTAKYRRYYHIEYFLLPDDGE;GVAQVSFADLL;INVIFLGAMQPSDLREYLEGPP;LCTPVYCKYQFFKTPVH;MSLHAWEWEDE;RERWSWDQRHQDFDLYKQPP;RHQDFDLYKQPPLF;TEEQKQDLNP;TKSLHDSHPAES;VLDRERWSWD 10 12 1.0027 -0.73415 0 10.0062 0 5.7054 12.3775 0 13.3718 0 0 0 6.95861 7.02181 10.9823 8.2949 8.83712 A0A8I3PKE8 A0A8I3PKE8_CANLF RRM domain-containing protein LOC119868776 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; syntaxin binding [GO:0019905] EEKLAALCKK;ENNNRVLLQMAEEK;ERLEKLCRALQAERNELR;EVLLMRDQ;IAMVVDVIEIILN;LEQYALREEHI;QFTLNEIQAQLE;SLKEENVQQAQ 8 12.6 1.0029 -0.78714 0 0 0 0 0 6.2461 8.59276 0 9.26838 0 0 9.56948 0 10.5334 0 A0A8I3PKE9 A0A8I3PKE9_CANLF PR/SET domain 14 PRDM14 Canis lupus familiaris (Dog) (Canis familiaris) cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ-line stem cell population maintenance [GO:0030718]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome by genomic imprinting [GO:0060818]; inner cell mass cell fate commitment [GO:0001827]; methylation [GO:0032259]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459] nucleoplasm [GO:0005654] chromatin DNA binding [GO:0031490]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] EDEGWSCS;IPVSLQVTEQGK 2 3.5 0.99206 -0.2078 0 0 10.3968 0 0 0 0 0 11.1376 10.9796 0 5.17193 10.0812 6.43774 10.319 A0A8I3PKF2 A0A8I3PKF2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] PIKKSPCP;PRVNPRRFRVKQPNLQYRWD 2 18.9 1.0032 -1.0562 0 0 6.39204 0 9.54102 5.97989 0 0 0 7.27435 0 7.00854 6.70708 7.13576 0 A0A8I3PKG3 A0A8I3PKG3_CANLF G protein-coupled receptor 151 GPR151 Canis lupus familiaris (Dog) (Canis familiaris) response to acidic pH [GO:0010447] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802] STTRLHAGVEVCLMD 1 3.6 0.98718 -0.22981 0 0 0 0 0 9.15125 0 0 0 0 0 0 0 0 0 A0A8I3PKH2 A0A8I3PKH2_CANLF Single-pass membrane protein with coiled-coil domains 3 LOC100686619 Canis lupus familiaris (Dog) (Canis familiaris) MKRDGTIKENCDIIIQ 1 7.1 0.99213 -0.035498 0 0 0 0 9.94509 0 0 0 0 0 0 0 0 0 0 A0A8I3PKI7 A0A8I3PKI7_CANLF Purine nucleoside phosphorylase (EC 2.4.2.1) (Inosine-guanosine phosphorylase) PNP Canis lupus familiaris (Dog) (Canis familiaris) purine ribonucleoside salvage [GO:0006166] purine-nucleoside phosphorylase activity [GO:0004731] FHMYEGYSLSK;YSEIPNFP 2 6.6 1.0026 -0.77627 0 0 0 0 0 0 0 0 0 0 0 0 8.81564 0 0 A0A8I3PKJ4 A0A8I3PKJ4_CANLF DNA-directed RNA polymerase subunit (EC 2.7.7.6) POLR2A Canis lupus familiaris (Dog) (Canis familiaris) "euchromatin [GO:0000791]; RNA polymerase II, core complex [GO:0005665]" core promoter sequence-specific DNA binding [GO:0001046]; metal ion binding [GO:0046872]; RNA polymerase II activity [GO:0001055] DLVKDVLSNAHIQN;EDQEWVNVYYEMPDFDV;GVPRSIAANM;KLGGLMDPRQGVIE;LRSTLCSRRMAEEFRLS;QLRYGEDGLAGE;VEQPEGDED;VLSPDELKR;VLSPDELKRMSV;YSPTSPAYEPRSP 10 6 1.0029 -1.5251 0 0 0 10.2708 10.3784 11.4136 9.2999 0 0 0 0 8.64393 9.47115 7.45541 9.11525 A0A8I3PKJ7 A0A8I3PKJ7_CANLF Netrin 4 NTN4 Canis lupus familiaris (Dog) (Canis familiaris) neuron remodeling [GO:0016322]; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling [GO:0060668] basement membrane [GO:0005604]; extracellular region [GO:0005576] laminin-1 binding [GO:0043237] AEVNVKIKKVLKSTKLKIL;GQNATELYCSYSENTD;IPDFHSTHNKSEPTWEWED;KGSHAEVNVKIKKVLKSTKLKILRG;NVKIKKVLKSTKLKILRGK;VGYWGFGDYGCRPCDCAGSCDP;VKIKKVLKSTKLKIL;VKIKKVLKSTKLKILR;VLGNSKAFCG 9 14.8 1.0014 -0.64016 0 8.53255 0 4.80105 7.12019 6.88203 0 0 0 0 9.10693 5.37705 6.69613 6.74457 5.9483 A0A8I3PKJ9 A0A8I3PKJ9_CANLF Membrane spanning 4-domains A5 MS4A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFSIMRRHFYCYDCDCC 1 8.5 0.98316 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 8.57012 0 A0A8I3PKK9 A0A8I3PKK9_CANLF Potassium voltage-gated channel subfamily E regulatory subunit 5 KCNE5 Canis lupus familiaris (Dog) (Canis familiaris) atrial cardiac muscle cell action potential [GO:0086014]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005] voltage-gated potassium channel complex [GO:0008076] potassium channel regulator activity [GO:0015459]; transmembrane transporter binding [GO:0044325]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008] ESQRLRTLLNR 1 8 0.9885 0.035491 0 0 0 0 0 0 0 0 6.20688 0 0 0 0 0 0 A0A8I3PKL1 A0A8I3PKL1_CANLF Claudin CLDN7 Canis lupus familiaris (Dog) (Canis familiaris) apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328] structural molecule activity [GO:0005198] GIIFIVGGLAAL;QIVTDFYNPLVPMNIKY;QIVTDFYNPLVPMNIKYEFGPA 3 16.1 0.9931 -0.17922 0 0 9.98014 0 0 0 0 0 0 0 4.16438 0 0 0 0 A0A8I3PKL4 A0A8I3PKL4_CANLF Uncharacterized protein LOC119864915 Canis lupus familiaris (Dog) (Canis familiaris) establishment of mitotic spindle localization [GO:0040001]; mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] ARTPSSRCCSQ 1 2.6 0.98328 -0.25374 0 0 0 0 9.77279 0 0 0 0 0 0 0 0 0 0 A0A8I3PKM6 A0A8I3PKM6_CANLF "FYVE, RhoGEF and PH domain containing 3" FGD3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] QTFKAFSSSF;TVSVLDPAEMP;VEAGIPSE;VYERLGGEE 4 5.2 1.0025 -2.1763 0 0 8.87599 0 0 0 0 13.2312 0 0 0 0 0 0 8.56148 A0A8I3PKN4 A0A8I3PKN4_CANLF Transglutaminase 5 TGM5 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] APPHMGQDISFVL;PGIIINVLGAAIV;TLYFRNRGFQPG 3 6 1.0015 -0.69717 0 0 0 13.1763 13.2996 13.3573 0 0 0 0 0 0 0 0 0 A0A8I3PKN5 A0A8I3PKN5_CANLF cAMP-responsive element-binding protein-like 2 CREBL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] SEIKALLT;VGGKVKKPGKRGRKPAK 2 20.8 1.0035 -1.0582 0 0 0 0 0 0 5.31375 0 0 0 0 0 0 0 7.06781 A0A8I3PKN6 A0A8I3PKN6_CANLF Solute carrier family 25 member 53 SLC25A53 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] TAIHDFLQRK 1 3 0.99818 -0.61146 0 0 4.82497 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PKP1 A0A8I3PKP1_CANLF Intersectin 2 ITSN2 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085] FFIKDLYQDVL;KLLKALRVRKK;LELEKRLEKQRELE;LIMSNTKLLKALRVRKKTGG;LIQKKKLEDEAIRKAKQGKE;LQSLDTMQPV;LSHMQAYIRF;PGQLILIL;QQQREAERKAQ;VLDKQCDLEIMEIKQ 10 7.2 1.0014 -2.6904 0 0 8.88512 0 0 0 4.88572 0 0 0 0 0 0 11.7774 7.08874 A0A8I3PKQ1 A0A8I3PKQ1_CANLF Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) PRKCI Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872] DNVLLDSEGHIK;DTTSTFCGTPNYIAPE;EMPTQRDSSAMSHAI;LFQVILEKQIRI;MPSDHVQTV;VLLVRLKKTDRIYAMK 6 12 0.9869 -0.23138 4.94734 0 0 0 7.7862 8.58101 0 0 0 0 10.9677 0 0 9.02492 9.82504 A0A8I3PKQ7 A0A8I3PKQ7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EIDQHIKKFLLRCR;GRPGCPLES 2 18.7 0.99194 -0.20855 0 11.4605 0 0 0 0 0 0 0 0 0 5.0694 0 0 0 A0A8I3PKR4 A0A8I3PKR4_CANLF "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (EC 2.7.1.159) (Inositol 1,3,4-trisphosphate 5/6-kinase)" ITPK1 Canis lupus familiaris (Dog) (Canis familiaris) inositol trisphosphate metabolic process [GO:0032957] "ATP binding [GO:0005524]; inositol tetrakisphosphate 1-kinase activity [GO:0047325]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]" AGPGCCGS;DWSGRHHVIP;GPDPPWTSEADAGGMGAGGT;NLSRPIEEQGPLDVIIHKLTDVILE;SGDDTMRLLEQN;VGYWLSEKKIKKLN;VIDINAFPGY 7 21.4 0.99035 -0.26822 0 0 0 0 0 0 0 9.55764 0 0 0 0 0 0 0 A0A8I3PKR6 A0A8I3PKR6_CANLF RPGR interacting protein 1 RPGRIP1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929] AEIPTEAGQYQ;AEIPTEAGQYQA;CRGHHRPAGV;FTFSDHDTAIIPAS;IKRARTALLRLTAARR;LEAVMTKADND;PLDDEKECQE;SEKMCIEVISL;SRMSREEL;VEQQREHPAER 10 8.6 1.002 -1.8348 8.01156 7.38767 0 0 10.0454 11.5094 9.43808 0 10.2974 0 0 0 6.22166 10.0464 10.4041 A0A8I3PKT3 A0A8I3PKT3_CANLF KIAA2026 KIAA2026 Canis lupus familiaris (Dog) (Canis familiaris) CLLMPQCN;DNHDISDEMDVKSSCEIRIH;EQSHKKIKLTK;ETCYRLHGVDHWI;HKKIKLTKMRAKKKKKKKKKLKDVL;IQNKLLIIKKKAKHKKHKSGK;KKKKKKKK;KKKKKKKKKL;KKKKKKKKKLKDVLNENLQRKRE;KKKKKKKKLKDV;KKKKKKKKLKDVLNENLQ;KLLIIKKKAKHK;KLTKMRAKKKKKKKKKL;KMRAKKKKKKKKKLK;KSPTVPEFQGKWYHR;LPKNFVIQHKEGK;LTKMRAKKKKKKKKKLKDVLNENLQ;NRSRLKKDYDDFRRQPDHDKFTREL;QKVWLLKGLCDFVYETQKE;RAKKKKKKKKKLK;SLTSVIKSPPAPLLAK;TKMRAKKKKKKKKKLKDVL 22 9 1.0011 -0.64412 0 7.36658 8.05284 2.88358 0 10.4393 0 7.7786 8.85244 8.89987 10.5421 0 5.14547 11.2329 6.58344 A0A8I3PKT4 A0A8I3PKT4_CANLF Complement C1s C1S Canis lupus familiaris (Dog) (Canis familiaris) complement activation [GO:0006956]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] DVFTTLTGEITSPNYPNP;PETRKNFNNDIAL;TCEEPYYYLEDEE;TVRREDFDVESADSNGHCPD;VIIHPDWEFLDDPETRKNFNNDIAL 5 11.6 0.98954 0.020188 8.92443 10.3903 0 6.7267 0 0 0 3.63204 0 0 0 0 0 4.8679 0 A0A8I3PKT6 A0A8I3PKT6_CANLF Leucine rich repeat transmembrane neuronal 2 LRRTM2 Canis lupus familiaris (Dog) (Canis familiaris) long-term synaptic potentiation [GO:0060291]; negative regulation of receptor internalization [GO:0002091]; positive regulation of synapse assembly [GO:0051965]; synapse organization [GO:0050808] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; postsynaptic specialization membrane [GO:0099634] GRWEHSILCHS;ITELERDQFASFS 2 4.7 0.59242 0.37748 9.10103 0 0 0 0 0 0 0 0 9.25607 0 0 0 0 0 A0A8I3PKU0 A0A8I3PKU0_CANLF TBC1 domain family member 15 TBC1D15 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] ESEKQQIMEKHY;GSGRIIYEQEGVYIHSSCGKTNDQ;QEKRNSRLRDYR;VITRIDLGERPVVQRREPVSLE;VVLPALHF 5 11.6 1.0041 -1.0989 7.20261 7.46606 0 0 0 0 0 0 9.98371 10.6897 0 0 0 11.4604 0 A0A8I3PKU6 A0A8I3PKU6_CANLF Nuclear receptor subfamily 5 group A member 2 NR5A2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] MVNYSYDE;PDEPQVQAK 2 3.4 1.003 -0.88404 9.45576 9.69936 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PKV2 A0A8I3PKV2_CANLF Transmembrane protein 94 TMEM94 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLLLLLNLLLIGRQDRLK;HSNRCSCFHWPG;KVLDFYQRACL;LLLIGRQDRLKRKEVERRLR;QEMLRCIWGHF;QSSIFTMC;VGGPWPGLHPAGCVQ;VIDNIRWCLDMALSRPVTALDNE;WKELWRSSFL 9 8.9 1.0027 -2.1846 0 0 10.5455 0 11.0286 0 10.7347 7.08204 0 10.7977 0 0 9.87929 0 7.24451 A0A8I3PKV3 A0A8I3PKV3_CANLF Tripartite motif containing 38 TRIM38 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of viral entry into host cell [GO:0046598] transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270] DTAHHELILSED;EHEMSCEEHGEHLHLFCEDESQL;EMEHEMSCEEHGE;ERSPRHKGHHTAL;GEATCAICLQLMSEP 5 14.1 1.0016 -0.75202 0 0 0 0 0 0 0 0 0 3.4769 0 0 9.24248 0 11.2133 A0A8I3PKV8 A0A8I3PKV8_CANLF GA binding protein transcription factor subunit beta 2 GABPB2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976] RVITIVTDGVPL 1 2.9 0.98338 -0.25372 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.92264 A0A8I3PKW6 A0A8I3PKW6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DTETECIC 1 5.1 1.0048 -1.1044 0 0 0 0 0 0 0 4.96343 0 0 0 0 0 0 0 A0A8I3PKX0 A0A8I3PKX0_CANLF Alanine--glyoxylate aminotransferase (AGT) (SPT) (EC 2.6.1.44) (EC 2.6.1.51) (Serine--pyruvate aminotransferase) AGXT Canis lupus familiaris (Dog) (Canis familiaris) "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; L-serine metabolic process [GO:0006563]" peroxisomal matrix [GO:0005782] alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine-pyruvate transaminase activity [GO:0004760] DPGDYYTL;LENSWRQH;QTKNPLTLAVSGS 3 7.5 0.98408 -0.24736 0 0 0 0 0 0 0 0 0 9.48325 0 0 0 0 0 A0A8I3PKX1 A0A8I3PKX1_CANLF Latent transforming growth factor beta binding protein 3 LTBP3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ENTRGGYRCAC;GPAPSQHLLPHPKPQH;LAPLLLLLLLGPGGG;LTFDDCCCRQ;PLLLGKPPREED;QPGYECYCKQ;RCTCAQGYAP;RTQCIADKPEEKSL;SEEDSDECRCVS 9 8.9 0.95476 0.053874 0 0 0 0 0 0 0 0 0 0 0 3.94505 0 0 0 A0A8I3PKX8 A0A8I3PKX8_CANLF Transmembrane protein 131 TMEM131 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAAGLLGA;AAARAEKEAFIQSESIIEV;AAGLLGALHLV;FSPIINIHNPHS;GFCGAGGS;HHVHSPLEQ;INCQEFALSANASK;IRFEPPMLDFHEQPVGMPK;LFINTSNHGV;LKRTFKVENTG;PFTTPASTLPSI;PRHLKFPL;SPPLEVFTEQP;VGMPKMEKVYL 14 8.3 1.0033 -2.1419 13.3267 12.4495 12.3756 12.6774 9.86318 7.90929 12.7671 14.4862 11.4449 11.3181 0 9.16895 12.9488 10.3278 12.0082 A0A8I3PKZ9 A0A8I3PKZ9_CANLF Mevalonate kinase MVK Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299] cytoplasm [GO:0005737] ATP binding [GO:0005524]; mevalonate kinase activity [GO:0004496] DTSFLGGPWRIWN;VLLVSAPG 2 25.3 0.98891 -0.2642 0 0 0 0 0 0 0 0 0 12.9927 0 0 0 0 0 A0A8I3PL11 A0A8I3PL11_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGG;EVQLVESGGELVKPG;EVQLVESGGELVKPGG;EVQLVESGGELVKPGGSLRL 6 24.6 0.68512 0.28525 10.7405 8.70936 13.4517 0 0 10.0916 13.4533 13.5744 0 0 0 0 10.1544 0 9.02176 A0A8I3PL13 A0A8I3PL13_CANLF Progestin and adipoQ receptor family member 5 PAQR5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] IFYRLFLV;LSLKLPRLF;WTHLLPFWFFVWRFVTAL 3 10.6 1.0023 -1.8603 0 0 9.79977 0 0 0 7.49265 0 0 0 0 0 0 8.85512 0 A0A8I3PL22 A0A8I3PL22_CANLF Transglutaminase 7 TGM7 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] DKIWNFHVWNECW;QMAALELRSVDLQSPRNNKEHH 2 4.9 0.98973 -0.19864 0 0 0 0 0 0 0 0 0 0 0 0 0 3.8268 9.09832 A0A8I3PL25 A0A8I3PL25_CANLF Zinc finger protein 317 ZNF317 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FTEKEWPLLDSSQRKLYKDVMLENY;YGRSCHLIAHKR;YHRRDCGAAFKN 3 8.7 0.98738 -0.22844 0 0 0 0 0 0 0 13.0419 0 0 0 0 0 0 0 A0A8I3PL31 A0A8I3PL31_CANLF Methylcrotonyl-CoA carboxylase subunit 1 MCCC1 Canis lupus familiaris (Dog) (Canis familiaris) "3-methylcrotonyl-CoA carboxylase complex, mitochondrial [GO:0002169]; mitochondrial matrix [GO:0005759]" ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methylcrotonoyl-CoA carboxylase activity [GO:0004485] AVTYNHDGSYSMQI;KKSFNDDAMLIEKFVD;QGDEVSVHYDPM;YLSSMSSGGTQG 4 7.4 0.935 0.10585 0 0 8.64559 0 0 0 0 0 0 9.2854 0 0 10.0211 0 0 A0A8I3PL38 A0A8I3PL38_CANLF Ig-like domain-containing protein TTN Canis lupus familiaris (Dog) (Canis familiaris) ATSTATLYVEARHIE;DPTMVVEWL;HYLGKKVKHRII;IDLEVFEMPPRFIMPIC;IEKQHAVVEF;ISELDQFYT;KLGDRNLPLPG;KTEIGASSRYITAINKNEELYET;KVAEHPQRPAS;LLSSQTWKEYEVEEREQE;PSRFFRMTQFED;VLCSREEIEGRFVSD;VTWFQNGLLLKQDQ;YESLMKSQ 14 3.3 0.98915 -0.51836 6.04361 0 7.08055 0 0 9.51031 0 0 8.29439 0 9.28623 10.1064 0 0 0 A0A8I3PL43 A0A8I3PL43_CANLF Nucleolar and spindle associated protein 1 LOC100683373 Canis lupus familiaris (Dog) (Canis familiaris) establishment of mitotic spindle localization [GO:0040001]; mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] HVNRVSFHKKTY 1 3.3 0.95347 0.05044 0 0 0 8.79305 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PL53 A0A8I3PL53_CANLF Integrator complex subunit 11 INTS11 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LPDGSVTV;VGISLGLLKREMAQG 2 4.6 1.0048 -1.0505 8.00017 0 5.21797 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PL61 A0A8I3PL61_CANLF Adhesion G protein-coupled receptor E3 ADGRE3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;ETFFEEANEK;HAYCVNGTQCTCD;LVIFLLILWILKKKL;SLHLQLSICLFLAHLLF;TTLPGMGEKGEV;VIFLLILWILKKK 7 11.7 0.9185 0.11343 0 0 7.28253 0 6.37827 0 0 0 0 0 0 0 0 0 0 A0A8I3PL71 A0A8I3PL71_CANLF Dystrotelin DYTN Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DVLHSIENSIYRT;RSCFQGVLSSTI 2 4.3 0.98263 -0.25035 0 0 0 0 0 0 0 0 9.48591 0 0 0 0 0 0 A0A8I3PL72 A0A8I3PL72_CANLF Dolichyldiphosphatase (EC 3.6.1.43) DOLPP1 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] endoplasmic reticulum membrane [GO:0005789] dolichyldiphosphatase activity [GO:0047874] SRVYLLYHTW;VGFVTLIIF 2 8 1.0026 -0.87874 0 0 0 8.07286 0 0 3.95615 0 0 0 0 0 9.92566 0 0 A0A8I3PL78 A0A8I3PL78_CANLF Nucleolar protein 9 NOL9 Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460] intermediate filament cytoskeleton [GO:0045111]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404] PLCSIVMLEQLKT;PLEQGFTFSGICRVTCLY;SAYTHSRLAINAVHYSMPEKSK 3 7.7 0.99316 -0.16506 6.63964 0 0 8.14262 6.0365 0 0 0 0 0 0 0 0 0 0 A0A8I3PL81 A0A8I3PL81_CANLF Small acidic protein C21H11orf58 Canis lupus familiaris (Dog) (Canis familiaris) DHDGEGDVAGDDDDDD;DHDGEGDVAGDDDDDDDS;EGDVAGDDDDDDDSPDPESPD;EVEDHDGE;GDVAGDDDDDDDSPDPESPDDSESD 5 18.1 1.001 -0.92414 0 8.98738 0 0 0 0 0 7.82712 6.82998 0 0 0 0 0 0 A0A8I3PL90 A0A8I3PL90_CANLF Ig-like domain-containing protein PALLD Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] axon guidance receptor activity [GO:0008046] AAQNLGPASGHGS;ADFFPELSAFLSQEE;LERKLRFK;PRGVPPPGF;PTKEPPPLLAKPK;SENLAFKSN;SPLLASPSYIRSL;SSSPDSGYLSPKNQPSTLMSASASQ;TNNISHPQP;VPTNNISHPQP 10 8.4 0.99717 -3.6229 0 9.224 8.28021 0 10.5871 7.77406 0 8.11837 7.81012 8.12366 7.05842 0 0 0 0 A0A8I3PL97 A0A8I3PL97_CANLF G protein-coupled receptor 143 GPR143 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-tyrosine binding [GO:0072545] EGGAHPVPVWL;LRVGVSRGLQRAAQE;TTWFIMVPMPAQLK 3 6.2 0.98977 -0.21146 0 0 0 0 0 7.76182 0 0 0 0 0 0 0 0 10.7595 A0A8I3PLA0 A0A8I3PLA0_CANLF Sulfotransferase (EC 2.8.2.-) HS3ST5 Canis lupus familiaris (Dog) (Canis familiaris) "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; regulation of viral entry into host cell [GO:0046596]" [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity [GO:0008467] ERIYKMNSSI;LHDLVQQLP;LVQQLPKAIIIGVRKGGTRALL;VGSLDRLQ 4 12.5 1.0024 -1.2271 5.33421 12.7236 0 0 0 0 0 0 9.71383 3.95065 0 0 0 0 13.0925 A0A8I3PLB2 A0A8I3PLB2_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP50 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck organization [GO:0035063]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]; regulation of cell cycle G2/M phase transition [GO:1902749] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] TAVRASISKAPKIIIF;TDIHYPLTNLDL;VSEIPDTSVQT 3 10.5 0.99444 -0.13111 0 0 0 0 5.63166 0 0 14.6657 0 0 0 0 0 0 0 A0A8I3PLB3 A0A8I3PLB3_CANLF Leucine rich repeat containing 75B LRRC75B Canis lupus familiaris (Dog) (Canis familiaris) VDLGNNVDVASL 1 3.9 0.99603 -0.092686 0 10.8553 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLB7 A0A8I3PLB7_CANLF Thyroid hormone receptor interactor 4 TRIP4 Canis lupus familiaris (Dog) (Canis familiaris) estrogen receptor signaling pathway [GO:0030520]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] activating signal cointegrator 1 complex [GO:0099053]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; RQC-trigger complex [GO:0180022] histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270] DQYPDMSQESDSPF;FRHMSRLSKKITIDF;IVCEQEGSGPCFFCGTLVCTREEQ;KGRNRQEVPAFAELDTTKE;QGNEDKKGQFIEEL 5 14.8 0.99241 -0.05131 0 0 0 0 5.86765 8.53586 10.9708 0 7.66661 0 0 0 0 2.58479 9.76832 A0A8I3PLB9 A0A8I3PLB9_CANLF NFKB repressing factor NKRF Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] GEAVKTLKKTQPTVINNLK;LDQLLALSAAWTNHVF;TELTNDERKQI 3 5.9 0.99148 -0.18525 0 8.85078 0 0 0 5.19109 0 0 9.9147 0 0 0 0 0 0 A0A8I3PLC8 A0A8I3PLC8_CANLF Protocadherin 18 PCDH18 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CVIFEYAESVTSTAMTSV;GDPVDTFVALVRVQDKDSGL;IPENYEEDDFDNV;SSNHVPENFSLELTHATPAV;SVQPSSKWLPAMEEIPENYEE;VPTMNGTLPIRSHHRS 6 8.9 0.99428 -0.024702 0 13.9173 0 0 6.98117 0 7.65585 0 0 0 0 0 0 0 6.28077 A0A8I3PLD1 A0A8I3PLD1_CANLF NTF2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] VEQTKVMQTQDYLLIASSGLL;YNNWSEQVSSGI 2 6.1 0.95424 0.050482 0 0 0 0 0 0 10.5153 0 0 0 0 0 0 0 0 A0A8I3PLE2 A0A8I3PLE2_CANLF Tetraspanin TSPAN11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MYYQRLSEE;TRTLAENYRQP;VLAHMYYQRLSE 3 10.2 1.0019 -1.2606 0 7.23199 0 0 0 0 0 0 0 9.49607 0 0 0 0 8.46185 A0A8I3PLE3 A0A8I3PLE3_CANLF Mitochondrial elongation factor 1 MIEF1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314] mitochondrial outer membrane [GO:0005741] ADP binding [GO:0043531]; GDP binding [GO:0019003]; identical protein binding [GO:0042802] GAAMLGIA;SSYWDRCVVGGYLSPK;VPGFYLVR 3 6.9 1.002 -1.3211 9.13119 5.13068 0 0 0 0 0 0 9.49037 0 0 0 0 9.40041 10.1236 A0A8I3PLE7 A0A8I3PLE7_CANLF Glutamate receptor GRIK1 Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" kainate selective glutamate receptor complex [GO:0032983]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734] kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] MTEYYHYFF;NQKKLKKKSRTKG;VSSLQCHRHKPW;WRGNGCPEE 4 4.7 1.0011 -0.93643 0 0 0 0 0 8.45035 0 0 0 9.66347 0 0 4.13529 0 0 A0A8I3PLE9 A0A8I3PLE9_CANLF Golgi SNAP receptor complex member 2 GOSR2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; membrane [GO:0016020] SNAP receptor activity [GO:0005484] EIQASIDQIFNHL;TLKVGLPG 2 10.8 0.99006 -0.26592 0 0 11.9959 11.8308 11.8024 11.9725 0 0 0 0 0 12.9042 12.4845 12.618 12.4471 A0A8I3PLF0 A0A8I3PLF0_CANLF S-phase cyclin A associated protein in the ER SCAPER Canis lupus familiaris (Dog) (Canis familiaris) antral ovarian follicle growth [GO:0001547]; retina development in camera-type eye [GO:0060041]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nuclear speck [GO:0016607]; ooplasm [GO:1990917]; sperm head [GO:0061827] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AALDLPAFQSIVGA;ADQIAFQVAGGLTAL;AESKKKHE;AESKKKHEEKQ;ANDVLSSEKAGI;ASAIAEEEQLTREIEAEENNDINI;DEIYETCESDQSVV;DESIQKGEFAG;DTRAHQPKGKSLGS;EAMEELQKKIQLKHDESIR;KTDAQSRPT;QARDEAVQE;TCNNCSENCTDVL;WETVQRGRPVRSR 14 12.7 1.002 -0.91029 10.9135 0 0 7.71143 11.8312 7.34616 0 11.7899 11.8083 6.55946 7.94093 0 11.3076 7.98356 12.426 A0A8I3PLF3 A0A8I3PLF3_CANLF Matrix remodeling associated 5 MXRA5 Canis lupus familiaris (Dog) (Canis familiaris) GNPWSCDCE;HGNPWSCDC;NYEKLWKLIAYYSEVPVKLNQELT;PSSTESETPVRAQDHHAT;SPATTLVSSVQA;SWTLPNTMLLEG;TVLEGSPCQLSCNVKAS;TVQQPQILASHYQ 8 3.8 1.002 -1.8373 7.32076 0 0 0 0 0 0 11.0081 14.8087 0 14.4033 4.25648 0 0 0 A0A8I3PLF4 A0A8I3PLF4_CANLF Chromosome 1 open reading frame 185 C1orf185 Canis lupus familiaris (Dog) (Canis familiaris) ISRNFHTGGFQLQR 1 12.3 0.94191 0.061072 0 8.3298 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLG5 A0A8I3PLG5_CANLF KANL3/Tex30 alpha/beta hydrolase-like domain-containing protein KANSL3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] NSL complex [GO:0044545] APGALHTLQSRLVATSPG;VIGQNSLQCHPEAMEDFREK 2 4.3 0.93529 0.097032 0 0 0 4.42915 0 0 0 0 0 0 0 0 0 7.52215 0 A0A8I3PLG8 A0A8I3PLG8_CANLF Potassium voltage-gated channel interacting protein 2 KCNIP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459] SLEDSVEDEFE 1 4.8 0.98383 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 7.62183 0 0 A0A8I3PLH1 A0A8I3PLH1_CANLF Uncharacterized protein TP53I3 Canis lupus familiaris (Dog) (Canis familiaris) NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; quinone binding [GO:0048038] LAVHFDEP;PIPAGLTLSQAAA;TSTAGAGQG 3 12 1.002 -1.2154 0 0 0 0 0 0 0 0 0 8.41007 9.71492 0 0 0 6.57853 A0A8I3PLI3 A0A8I3PLI3_CANLF WW domain-containing oxidoreductase WWOX Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; hippo signaling [GO:0035329]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Wnt signaling pathway [GO:0016055] Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634] transcription coactivator activity [GO:0003713] LSTFLPIENNLI;PSKSDYWAMLAYNRSKLC 2 7.4 0.93462 0.098753 0 9.33201 0 0 0 0 0 0 0 0 0 0 0 0 6.13902 A0A8I3PLI5 A0A8I3PLI5_CANLF AVL9 cell migration associated AVL9 Canis lupus familiaris (Dog) (Canis familiaris) recycling endosome [GO:0055037] DLVLHFRHKVLILFKLIL;DLVLHFRHKVLILFKLILL;DYGTTFVT;FRHKVLILFKLI;HFRHKVLILFKLI;KVLILFKLILLEKKVLFYISPVNK;LILFKLILLEKKVL;PSDSPPITVQPQ;VLHFRHKVLILFKLILL;VLHFRHKVLILFKLILLEKKVL;VRHVTENRDDVFLDGT 11 11.3 0.99098 -0.00039796 0 0 0 6.84046 9.42828 3.68751 6.04736 0 6.22907 5.15813 0 0 9.18522 0 5.92557 A0A8I3PLK1 A0A8I3PLK1_CANLF Bifunctional purine biosynthesis protein ATIC (EC 2.1.2.3) (EC 3.5.4.10) (AICAR transformylase/inosine monophosphate cyclohydrolase) ATIC Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643] LFSVSDKTGLVE;SYNPDENE;TVVCEPEDYVA;WVDKLSEVSISSDAFFP 4 8.1 1.0027 -1.7644 9.59352 0 0 2.70494 0 0 0 0 7.71713 0 0 0 0 13.4101 0 A0A8I3PLK3 A0A8I3PLK3_CANLF Eukaryotic translation initiation factor 5A-1 (Eukaryotic initiation factor 5A isoform 1) (eIF-4D) EIF5A Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; synapse [GO:0045202] ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746] CGSGGMGL 1 4.3 0.98941 -0.26592 0 0 0 0 0 0 0 0 0 0 0 9.03111 0 0 0 A0A8I3PLL0 A0A8I3PLL0_CANLF TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TAB1 Canis lupus familiaris (Dog) (Canis familiaris) aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of MAPK cascade [GO:0043410]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear speck [GO:0016607] molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine phosphatase activity [GO:0004722] DVVERSFLESIDDALAE;LVMPSQGQLVNGAHSASTLDEAT;PRHEDMTLL;SGGAMAVV 4 11.3 1.0032 -2.071 0 5.47978 0 0 7.96434 8.22125 0 0 4.54955 0 9.1152 0 0 0 11.1923 A0A8I3PLN5 A0A8I3PLN5_CANLF Adenosine deaminase like ADAL Canis lupus familiaris (Dog) (Canis familiaris) adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103] adenosine deaminase activity [GO:0004000] HQLTTSPEDILM;QMFQIIHQLTTSPEDIL;SLELVDFVRQHQI 3 9.4 0.99219 -0.20779 8.41414 0 0 0 0 8.63343 0 0 0 0 0 0 0 0 0 A0A8I3PLN6 A0A8I3PLN6_CANLF Chromosome 19 open reading frame 38 C20H19orf38 Canis lupus familiaris (Dog) (Canis familiaris) EDPIHIACVA;VLLLAGLVTVAVVVRKVKV;VLLLAGLVTVAVVVRKVKVRNLQKK 3 15.3 0.98961 -0.52651 0 0 0 0 6.91648 0 0 8.00871 0 0 0 8.81012 0 0 0 A0A8I3PLN7 A0A8I3PLN7_CANLF Gem nuclear organelle associated protein 6 GEMIN6 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; SMN complex [GO:0032797] RNA binding [GO:0003723] ENCSSPNEIILSRV 1 8.4 0.93787 0.060873 0 0 0 0 0 0 0 0 0 0 7.53885 0 0 0 0 A0A8I3PLN9 A0A8I3PLN9_CANLF "Alcohol dehydrogenase 4 (class II), pi polypeptide" ADH4 Canis lupus familiaris (Dog) (Canis familiaris) alcohol catabolic process [GO:0046164]; cellular aldehyde metabolic process [GO:0006081]; ethanol metabolic process [GO:0006067]; fatty acid omega-oxidation [GO:0010430]; quinone metabolic process [GO:1901661]; retinol metabolic process [GO:0042572] cytosol [GO:0005829]; nucleoplasm [GO:0005654] "alcohol dehydrogenase (NAD+) activity, zinc-dependent [GO:0004024]; aldose reductase (NADPH) activity [GO:0004032]; all-trans retinal binding [GO:0005503]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; benzaldehyde dehydrogenase [NAD(P)+] activity [GO:0019115]; NAD binding [GO:0051287]; NADPH:quinone reductase activity [GO:0003960]; retinol binding [GO:0019841]; zinc ion binding [GO:0008270]" TAKVTPGSTCAVFGLG 1 4.2 0.67893 0.27984 0 0 0 0 0 0 0 0 0 12.8219 0 0 7.63481 0 0 A0A8I3PLP4 A0A8I3PLP4_CANLF Coiled-coil domain containing 124 CCDC124 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; plasma membrane [GO:0005886] transcription coactivator activity [GO:0003713] AADRHPERRMRAAFTAFEEAQL 1 9.9 0.9876 -0.26472 0 0 0 0 0 0 0 0 0 0 10.1478 0 0 0 0 A0A8I3PLP8 A0A8I3PLP8_CANLF Chromosome 29 C8orf34 homolog C29H8orf34 Canis lupus familiaris (Dog) (Canis familiaris) PSGSKFNQGRATHPAEPQ 1 4.2 0.98797 -0.22767 0 0 0 0 0 0 0 0 0 0 0 0 9.25226 0 0 A0A8I3PLQ0 A0A8I3PLQ0_CANLF Ras related dexamethasone induced 1 RASD1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DAYTPTIE;FHRKFYSIRGE;LTGRFEDAYTPTIEDF;SGGGDPGD 4 12.2 1.0021 -1.798 0 10.0308 0 0 0 0 0 0 0 0 0 4.59729 0 0 6.504 A0A8I3PLQ2 A0A8I3PLQ2_CANLF Poly(A) binding protein cytoplasmic 4 like PABPC4L Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] RLFVGRFQSRQARE;VGRAQRKAERQAELRRAFEQRQQDG 2 10.5 0.99256 -0.28328 0 0 0 0 0 0 0 0 0 0 0 5.58814 0 0 0 A0A8I3PLQ5 A0A8I3PLQ5_CANLF PHD finger protein 14 PHF14 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CDNCGITVHEGCY;CSECDQAGS;DEDEGSGSDEDENDEGNDEDHSS;DNEDDEDEGSGSDEDENDEGNDE;EDPSKDSGEGSCSDSE;GSDEDENDEGNDEDHSSPASEG;LDFVSMEELNDMDDYDSEDDNDW;NDMDDYDSEDDND;NEDDEDEGSGSDEDENDEGNDE;NENLVRCDECRLCYHFG;SDEDENDEGNDEDHSSPASEGGC;WQCSECDQAGS;WQCSECDQAGSSDM 13 12.4 1.0015 -0.91697 0 11.0681 7.35244 4.09626 7.51246 0 5.68815 11.3415 0 0 3.34369 0 6.12207 5.80126 0 A0A8I3PLR6 A0A8I3PLR6_CANLF DNA/RNA-binding protein Alba-like domain-containing protein LOC486757 Canis lupus familiaris (Dog) (Canis familiaris) tRNA 5'-leader removal [GO:0001682] nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172] RNA binding [GO:0003723] KRRVPGLHQL;TSSSSCGP 2 11 1.0022 -1.4254 0 9.4544 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLR9 A0A8I3PLR9_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VTVSGNLLIVVTIIR 1 5.2 0.95069 0.053874 0 0 0 0 0 0 0 0 4.50309 0 0 0 0 0 0 A0A8I3PLS5 A0A8I3PLS5_CANLF SREBP regulating gene protein LOC119869843 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of SREBP signaling pathway [GO:2000640] Golgi membrane [GO:0000139] ENTYRDPIAK 1 4.9 0.99435 -0.16328 0 11.3594 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLS6 A0A8I3PLS6_CANLF Glutathione hydrolase (EC 2.3.2.2) (EC 3.4.19.13) (Gamma-glutamyltransferase) (Gamma-glutamyltranspeptidase) GGT1 Canis lupus familiaris (Dog) (Canis familiaris) glutathione catabolic process [GO:0006751] membrane [GO:0016020] acyltransferase activity [GO:0016746]; glutathione hydrolase activity [GO:0036374] IQAAGGIVTAKDLNNYRAN;NMFNSSEQSQTG;TMPRLAETYKTLA;VGVAIVLILIIGL;VVGASGGT 5 11.4 1.002 -1.4771 10.4083 13.2768 0 0 0 0 11.6649 0 9.10596 0 0 0 0 0 0 A0A8I3PLU0 A0A8I3PLU0_CANLF Interferon regulatory factor 3 IRF3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to virus [GO:0098586]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; programmed necrotic cell death [GO:0097300]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; type I interferon-mediated signaling pathway [GO:0060337] chromatin [GO:0000785]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GLALWRAGQQLWARR;VGEPWPQDQPWTKK 2 6.8 0.99221 -0.54185 0 0 0 0 0 0 0 0 0 0 0 0 9.19338 0 0 A0A8I3PLU5 A0A8I3PLU5_CANLF Golgi SNAP receptor complex member 2 GOSR2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794]; membrane [GO:0016020] SNAP receptor activity [GO:0005484] EIQASIDQIFNHL;TNVSQAWGGDLQVLGGSL 2 21.7 0.86278 0.17422 0 0 0 0 0 0 0 10.5116 0 0 0 3.92552 14.2555 0 5.40231 A0A8I3PLU9 A0A8I3PLU9_CANLF H6 family homeobox 3 HMX3 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; embryo implantation [GO:0007566]; inner ear morphogenesis [GO:0042472]; maternal process involved in female pregnancy [GO:0060135]; neuromuscular process controlling balance [GO:0050885] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" TFPHPVYYSHPV 1 3.4 0.95445 0.05044 9.11894 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLV2 A0A8I3PLV2_CANLF Protein AAR2 homolog (AAR2 splicing factor homolog) AAR2 Canis lupus familiaris (Dog) (Canis familiaris) FRGVKMIP;GGGGGGGG;HWGGGGGG;NLQELDQFLGPYPYATLKK;VEQNLPRCGTECK;WGGGGGGG 6 10.8 1.0021 -2.6197 0 13.3659 0 0 12.3026 0 0 0 11.9228 0 0 0 0 0 0 A0A8I3PLV8 A0A8I3PLV8_CANLF Leucine rich repeats and IQ motif containing 4 LRRIQ4 Canis lupus familiaris (Dog) (Canis familiaris) DIQHLKNLRILYLNK;VPREITDLEELEEVHLE;YVENNHLEYLPTSLG 3 8.3 0.85845 0.15402 13.088 0 0 0 0 0 0 9.90654 0 0 0 6.08748 0 0 0 A0A8I3PLW0 A0A8I3PLW0_CANLF Trichohyalin like 1 TCHHL1 Canis lupus familiaris (Dog) (Canis familiaris) transition metal ion binding [GO:0046914] DQQNPAKKGYDVSV;LDLQVTSSTGQQTEQTP 2 3.4 0.99166 0.011463 0 0 0 0 12.3141 0 0 0 0 0 10.9447 0 0 0 0 A0A8I3PLW4 A0A8I3PLW4_CANLF Sex hormone-binding globulin SHBG Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] steroid binding [GO:0005496] ATLPGWLLILLLLL;FELRTWDPEGV;TWDPEGVIFYGDTNSKDDWFVLGLR 3 14.8 0.88364 0.1318 0 7.66952 0 0 0 0 0 0 0 0 0 0 0 0 8.5735 A0A8I3PLX1 A0A8I3PLX1_CANLF Signal peptide peptidase like 2A SPPL2A Canis lupus familiaris (Dog) (Canis familiaris) membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; regulation of immune response [GO:0050776] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; Golgi-associated vesicle membrane [GO:0030660]; late endosome membrane [GO:0031902]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]" FTVALGGYWSG;LAALIRKIPCGQCT;QPSAPHEKLPVVIRV 3 7.6 0.99203 -0.55012 0 0 0 0 10.722 11.4888 0 0 0 0 0 0 0 11.1684 0 A0A8I3PLY3 A0A8I3PLY3_CANLF "5',3'-nucleotidase, mitochondrial" NT5M Canis lupus familiaris (Dog) (Canis familiaris) deoxyribonucleotide catabolic process [GO:0009264] 5'-nucleotidase activity [GO:0008253] LFTACHNRHLQ 1 4.7 0.9909 -0.20961 0 0 11.09 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PLY8 A0A8I3PLY8_CANLF P2Y receptor family member 10 P2RY10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] HINFIFYTMVKETII;NVTFQNSLYATTYIL;YISHHWPFPK 3 10.3 1.0018 -0.71089 0 0 0 0 0 0 10.1736 0 0 0 8.05842 0 12.736 0 0 A0A8I3PLZ7 A0A8I3PLZ7_CANLF Short stature homeobox 2 SHOX2 Canis lupus familiaris (Dog) (Canis familiaris) cardiac right atrium morphogenesis [GO:0003213]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte development [GO:0002063]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal joint morphogenesis [GO:0060272]; mesenchymal cell proliferation [GO:0010463]; muscle tissue morphogenesis [GO:0060415]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of axonogenesis [GO:0050772]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of skeletal muscle fiber development [GO:0048743]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of chondrocyte differentiation [GO:0032330]; regulation of heart rate [GO:0002027]; sinoatrial node cell development [GO:0060931]; sinoatrial valve development [GO:0003172]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAGGGGGG;GGGAGGGR;GGGGGGGA;GGGGGGGG;HYPDAFMREELSQRLGLSEARVQVW 5 16.9 0.99053 -0.2982 0 9.2075 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PM00 A0A8I3PM00_CANLF Hermansky-Pudlak syndrome 3 protein homolog HPS3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RCSAAAAREEDPYV;SSYVLADDIKLHSLQ 2 3.5 0.99233 -0.18444 9.69665 0 0 11.5716 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PM03 A0A8I3PM03_CANLF Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) DPH3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein secretion [GO:0050709]; protein histidyl modification to diphthamide [GO:0017183] cytosol [GO:0005829]; nucleoplasm [GO:0005654] EVEIEDFQYDED;SCSLIIKVIYDK 2 29.3 0.98871 -0.26432 0 0 0 0 10.2298 0 0 0 0 0 0 0 0 0 0 A0A8I3PM09 A0A8I3PM09_CANLF Cation channel sperm associated 2 CATSPER2 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] CatSper complex [GO:0036128] calcium-activated cation channel activity [GO:0005227] EVSRAFSSI 1 1.7 0.99191 -0.17092 9.33642 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PM36 A0A8I3PM36_CANLF Kininogen 1 KNG1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion [GO:0007162]; negative regulation of proteolysis [GO:0045861]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; vasodilation [GO:0042311] extracellular space [GO:0005615] cysteine-type endopeptidase inhibitor activity [GO:0004869]; hormone activity [GO:0005179] ASPELEPV;ESLSEEIDCNDE;GFSPFRSSFMEKTEK;RPPGFSPF;RPPGFSPFRSSF;TESDDDWIPDIQ;TFYSFKYQI 7 9.2 0.94199 0.05044 0 0 0 0 7.10852 0 0 0 0 0 0 0 0 0 0 A0A8I3PM43 A0A8I3PM43_CANLF Large ribosomal subunit protein eL36 (60S ribosomal protein L36) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KRALKFIKKWVG 1 10.8 0.99234 -0.2874 0 0 0 0 0 4.45372 0 0 0 0 0 0 0 0 0 A0A8I3PM44 A0A8I3PM44_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;EVKAAVRRTLGKYLL 2 8.5 0.98382 -0.24378 0 0 0 0 0 0 0 0 0 0 0 6.13268 0 0 0 A0A8I3PM45 A0A8I3PM45_CANLF Zinc finger and SCAN domain containing 29 ZSCAN29 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837] AEETIEEDSEDDEEDT;TILPGEIQNWVQEQCPE;VGSDPETEEPGQGGWQ;VTKKERARSPD 4 7 0.86497 0.18018 0 5.4162 6.26029 0 0 6.70708 0 5.615 0 0 0 0 0 0 0 A0A8I3PM46 A0A8I3PM46_CANLF Guanylate cyclase (EC 4.6.1.2) GUCY2F Canis lupus familiaris (Dog) (Canis familiaris) detection of light stimulus involved in visual perception [GO:0050908]; intracellular signal transduction [GO:0035556] membrane [GO:0016020]; rod photoreceptor outer segment [GO:0120200] ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; protein kinase activity [GO:0004672] GTIYNSIYFIA;LEIEKQKTEK;MTDGTYVFVPY;SPIRVLVTVMK;VDLLNDLYTLFDA 5 5.1 1.0017 -1.2561 0 0 0 0 0 0 0 0 0 7.34669 0 0 0 9.90293 0 A0A8I3PM51 A0A8I3PM51_CANLF ANTXR cell adhesion molecule 1 ANTXR1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; blood vessel development [GO:0001568]; negative regulation of extracellular matrix assembly [GO:1901202]; reproductive process [GO:0022414]; substrate adhesion-dependent cell spreading [GO:0034446] external side of plasma membrane [GO:0009897]; filopodium membrane [GO:0031527]; lamellipodium membrane [GO:0031258] actin filament binding [GO:0051015]; collagen binding [GO:0005518]; transmembrane signaling receptor activity [GO:0004888] DLGAIVYCVGVKDFNETQLAR;GDTGRCINFTRVKNNQ;SILAIALLILFLLLALAL;TDGELHED 4 11.2 1.0022 -1.2231 0 0 0 0 0 7.18041 0 0 9.14687 0 0 0 5.6975 9.80452 0 A0A8I3PM53 A0A8I3PM53_CANLF Inactive ribonuclease-like protein 10 RNASE10 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; single fertilization [GO:0007338] extracellular region [GO:0005576] nucleic acid binding [GO:0003676] DEVVGNKVGG;EDEVVGNK;TFIFEKYIIISCNDM 3 12.1 1.0026 -0.79952 0 8.05208 0 0 0 0 0 0 0 0 7.70632 8.36054 0 0 0 A0A8I3PM58 A0A8I3PM58_CANLF Erythrocyte membrane protein band 4.1 like 1 EPB41L1 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] actin binding [GO:0003779]; structural molecule activity [GO:0005198] GAGSPENHVRPDGLEASVEQLG;GGASLAAGCTPA;GRPAASGSRS;PEERLKVATMQQ;QVLPPPLEKREEHSDALPV;SEDQVLPPPLEK;TEPVSPDSGCETALE 7 5.9 1.0033 -0.86719 0 6.42269 0 0 11.0924 0 0 11.5325 0 0 0 0 0 0 13.1076 A0A8I3PM67 A0A8I3PM67_CANLF Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) ADCY5 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] cilium [GO:0005929]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] DDDPPLGGDDPLA;EQQQHVQQQQRL;LVMAVLCNRAAFHQDH;NPPHWGAERP;VLCNRAAFHQDHM 5 4.5 1.0033 -1.0565 0 0 0 0 6.34433 0 9.58978 0 0 0 0 0 0 9.57465 9.18532 A0A8I3PM73 A0A8I3PM73_CANLF Pre-mRNA-splicing factor SPF27 BCAS2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" centrosome [GO:0005813]; DNA replication factor A complex [GO:0005662]; nuclear speck [GO:0016607]; precatalytic spliceosome [GO:0071011]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] LVSKNYEIERT 1 4.9 0.98415 -0.25342 0 0 0 8.41895 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PM75 A0A8I3PM75_CANLF PDZ and LIM domain 5 PDLIM5 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ANANLSADQHSSALSAGKPAVNVP;GEPYCETDYYA;MEDTEDWRPRTGTTQSRSFRILAQ;TWHDTCFVCSVCCESL 4 12.6 0.99339 -0.28609 0 0 0 0 0 0 0 9.99195 0 0 0 0 0 0 0 A0A8I3PM76 A0A8I3PM76_CANLF Dynactin subunit 3 DCTN3 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent cytokinesis [GO:0061640] dynactin complex [GO:0005869] ARLQRLAQIHIQQQALVFTLTCY;LDPEYIDRI 2 18.2 1.0042 -1.0866 0 0 0 0 0 0 0 0 0 0 9.70439 0 0 0 11.7756 A0A8I3PM94 A0A8I3PM94_CANLF AMP deaminase (EC 3.5.4.6) AMPD1 Canis lupus familiaris (Dog) (Canis familiaris) GMP salvage [GO:0032263]; IMP salvage [GO:0032264] AMP deaminase activity [GO:0003876]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] LPEIDDTLRSFAEKVFASE;LPHFGKMLENVFMPVFEATI;LSHIDEYI;LSTWFVRNRIYCHNMT;MHPYDLTVDSLDVHAGRQTFQRF 5 11.5 0.98492 -0.24055 0 0 0 0 0 0 0 0 0 9.20193 0 0 0 0 0 A0A8I3PM97 A0A8I3PM97_CANLF Centrosomal protein 295 CEP295 Canis lupus familiaris (Dog) (Canis familiaris) DSFATLPSARAE;EKSGEELSDRQTQL;EVTTTVSETESKAPTVESGAT;EWQKQVAQERMEQHE;KPLSMDTDSEREQVQP;LNQHELSAIPEVESPAS;LQGQLNTQRDSLQARRE;SESGRIQEPCSTKS;SQDSRDFYQNSDSSCESH;TELLLHRQRDLGNGK 10 7 0.95608 0.049233 0 0 4.74803 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PMA8 A0A8I3PMA8_CANLF BPI fold containing family B member 6 BPIFB6 Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] DAVLVYVNKKW;KIQYSVHENRLQM;SSSIGAFNEKKLTDFITDYLREAYV 3 10.9 0.88235 0.13065 0 0 0 0 0 9.08722 0 0 8.94037 0 0 0 4.5903 8.93198 0 A0A8I3PMB6 A0A8I3PMB6_CANLF Suppressor of cytokine signaling 2 SOCS2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567] QTLEGRWKQ;QTLEGRWKQNLP 2 4.5 0.98555 -0.44161 0 0 0 0 0 0 9.80729 0 0 0 0 0 0 0 0 A0A8I3PMC8 A0A8I3PMC8_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] TVNNEKVWTLVNE;YHLNRNQNFCSTVNNE 2 20.2 0.99291 -0.16853 0 0 0 0 0 0 0 0 0 0 9.08728 0 0 13.5486 0 A0A8I3PMD4 A0A8I3PMD4_CANLF Nuclear autoantigenic sperm protein AKR1A1 Canis lupus familiaris (Dog) (Canis familiaris) CENP-A containing chromatin assembly [GO:0034080]; DNA replication-dependent chromatin assembly [GO:0006335]; nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleoplasm [GO:0005654] histone binding [GO:0042393]; oxidoreductase activity [GO:0016491] AAPEGLNEAKVAS;AAVNAFQEAASL;EEGKSVCGTDVQDEC;GLAYGYNSQYDEAV;LGSSDRAWRDPD;VEQQTNVEELTETKDGS 6 8.1 0.99163 -0.1483 0 0 0 0 0 0 0 0 0 0 0 0 11.4167 0 0 A0A8I3PMD5 A0A8I3PMD5_CANLF Uncharacterized protein CETN2 Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289] centriole [GO:0005814]; centrosome [GO:0005813] calcium ion binding [GO:0005509] EVNEQEFL 1 4.7 0.99162 -0.18525 0 0 0 0 0 0 0 0 0 0 0 0 10.0364 0 0 A0A8I3PMD6 A0A8I3PMD6_CANLF Matrix metallopeptidase 11 MMP11 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane organization [GO:0071711]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; negative regulation of fat cell differentiation [GO:0045599]; proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] ALRALLLPLLLLLLPPPPLLAWAPR;APLEPEAPPDACEI;EDAQGHIWFFQ;LLLPLLLLL;LLLPLLLLLL;LRGAALRALLLPLLLLLLPPPPL;VHFDYDETWTIGNNQ 7 14.1 1.0018 -0.67529 11.1362 0 7.20271 0 0 0 0 0 0 0 7.18824 7.17503 8.048 0 0 A0A8I3PMD7 A0A8I3PMD7_CANLF Regulator of G protein signaling 21 RGS21 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]; transmission of nerve impulse [GO:0019226] ISKNIAEPTL;KMIYSEFIEAD;NIAEPTLKCFDEAQKLIYSLMAKDS;RFLKSEIY 4 30.9 1.0043 -1.0787 0 0 0 0 0 0 11.2282 0 0 0 0 0 0 0 16.9519 A0A8I3PME0 A0A8I3PME0_CANLF Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 Canis lupus familiaris (Dog) (Canis familiaris) intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031] Golgi membrane [GO:0000139]; Golgi transport complex [GO:0017119] LQFQIEAHLDTLINEQASY;VKSLAWFPESL 2 4.6 0.98949 -0.52204 0 0 0 0 0 0 0 0 10.2305 0 0 0 0 0 0 A0A8I3PME4 A0A8I3PME4_CANLF Transporter SLC6A5 Canis lupus familiaris (Dog) (Canis familiaris) "glycine import across plasma membrane [GO:1903804]; synaptic transmission, glycinergic [GO:0060012]" plasma membrane [GO:0005886]; synapse [GO:0045202] glycine:sodium symporter activity [GO:0015375] FIMGFPMITQ;FLAQHRGE;RFPYLAFQNGGGAFLIPY;VLGTDGITSVLPGSVASAAAQE;YFITPKWE;YVVLVILLIRGVTLPGAGA 6 11.1 1.003 -2.3522 8.01731 0 0 0 9.12993 0 8.97648 0 0 0 0 0 0 0 0 A0A8I3PMF6 A0A8I3PMF6_CANLF Glutamate rich 2 ERICH2 Canis lupus familiaris (Dog) (Canis familiaris) DDDGEDDTNDEDDEDSN;DDTNDEDDEDSNPN;ELSEESSDECED;ESEGESSEELSEESSDECEDE;FQDIDDKLSESTDDDGEDDTNDED;GEDDTNDEDDEDSNP;SESTDDDGEDDTN;TDDDGEDDTNDEDDEDSNPNKDTHA 8 37 0.9292 0.094747 7.30268 0 0 0 0 0 0 6.06904 0 0 7.37539 0 7.16189 0 10.4616 A0A8I3PMG6 A0A8I3PMG6_CANLF Acyl-coenzyme A oxidase ACOX1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; very long-chain fatty acid metabolic process [GO:0000038] peroxisome [GO:0005777] FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; palmitoyl-CoA oxidase activity [GO:0016401] EAYKLRAAR;LETTATYD;LPGCITVGDIGPKFGYDEMDNGY;NAAIEACRMACGGHGY;NVYEHLFEWAKKSPL;PLLATAYAFQFV;VSYLNDLPTQ 7 14 0.9774 0.046348 0 0 0 0 0 0 0 0 0 0 0 0 8.79022 0 0 A0A8I3PMJ2 A0A8I3PMJ2_CANLF Tetratricopeptide repeat domain 21B LOC119869086 Canis lupus familiaris (Dog) (Canis familiaris) LEMHQNYSGALEAV;TLAPEQQEAL;YKITLAFSRTCGRSQLILQKIQ 3 4.3 0.98874 0.030083 0 0 0 0 0 0 0 0 0 0 11.2627 0 0 0 0 A0A8I3PMJ5 A0A8I3PMJ5_CANLF "Methionyl-tRNA formyltransferase, mitochondrial (EC 2.1.2.9)" MTFMT Canis lupus familiaris (Dog) (Canis familiaris) methionyl-tRNA formyltransferase activity [GO:0004479] DRFAREALRALHA;TSCIKWEEQTSEQI;VLFFGTDRFAREA 3 7.2 0.99138 -0.13387 0 0 0 0 0 8.71781 0 0 8.51365 9.56505 0 0 0 0 0 A0A8I3PMK8 A0A8I3PMK8_CANLF Uncharacterized protein ROPN1 Canis lupus familiaris (Dog) (Canis familiaris) sperm capacitation [GO:0048240] cytoplasm [GO:0005737]; motile cilium [GO:0031514] QEVIGPDGLIKVN;RQANMHPPRAAGAAE 2 14.5 0.99591 -0.016961 0 8.15997 0 0 10.0721 0 8.70867 0 0 0 0 0 0 0 0 A0A8I3PML4 A0A8I3PML4_CANLF Patatin like phospholipase domain containing 4 PNPLA4 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] retinyl-palmitate esterase activity [GO:0050253]; triglyceride lipase activity [GO:0004806] LTAPEKLEECNEFTYK;SFSSREDLIKVL 2 11.5 0.99153 -0.27068 0 0 0 0 0 0 0 9.29366 0 0 0 0 0 0 0 A0A8I3PML7 A0A8I3PML7_CANLF Ig-like domain-containing protein LOC119868806 Canis lupus familiaris (Dog) (Canis familiaris) DSIGSKSVYWYQQKLG;GLPHVLHKNISLHPP;PSMSVTLRQT;YVLTQLPSM 4 31.1 0.94087 0.10312 0 0 0 0 0 0 0 9.54547 0 0 5.61545 0 0 0 0 A0A8I3PML9 A0A8I3PML9_CANLF Arylsulfatase L ARSL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787] GMPFSMMGDC;GVLLGARPSACRDLSGSR;KGGKGMGG 3 6.4 1.0027 -1.3787 0 0 0 0 0 0 0 8.04199 9.608 0 0 0 0 0 0 A0A8I3PMM4 A0A8I3PMM4_CANLF Histone H2A/H2B/H3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] SHTVSPPA 1 6.6 1.0044 -1.1044 0 0 0 0 0 0 0 0 5.51033 0 0 0 0 0 0 A0A8I3PMN4 A0A8I3PMN4_CANLF Metal transporter CNNM4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular manganese ion homeostasis [GO:0030026]; magnesium ion homeostasis [GO:0010960] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095]; sodium ion transmembrane transporter activity [GO:0015081] GGGSRRAL;LISEKILLRLLKY;LRLLKYPDVIQELKF;NKTCGMNPDGI;TQLQDCFMIRSDAILDFN;VLGQEIRTVYNRE 6 10.3 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 0 6.46547 0 0 0 0 A0A8I3PMN7 A0A8I3PMN7_CANLF Developmentally regulated GTP binding protein 2 DRG2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosol [GO:0005829]; nucleoplasm [GO:0005654] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723] CIPGVIEYKGAN;HEYKIFNAE;SASSKGEG 3 8 1.0032 -1.6293 0 0 0 0 0 8.99317 0 0 0 0 0 9.58472 0 10.0583 0 A0A8I3PMN9 A0A8I3PMN9_CANLF E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) TRIM71 Canis lupus familiaris (Dog) (Canis familiaris) 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube closure [GO:0001843]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] P-body [GO:0000932] miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] FCQQHDDEVLHLYCD;FGFVSSGAFAPLTKATGD;GGGGGGPG;IVADSRNHRVQ;VADSRNHRVQ 5 6 1.0019 -1.365 0 0 0 0 0 11.1518 7.68762 0 0 0 0 0 0 0 9.51325 A0A8I3PMP7 A0A8I3PMP7_CANLF DUF4587 domain-containing protein PRR29 Canis lupus familiaris (Dog) (Canis familiaris) GADVPPASDYYG;PRVTVLQPVAW 2 12.4 0.99143 -0.20935 0 0 0 0 0 0 12.3457 0 0 0 0 0 0 4.66209 0 A0A8I3PMP8 A0A8I3PMP8_CANLF Ubiquitin like modifier activating enzyme 7 UBA7 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ATP binding [GO:0005524]; ubiquitin-like modifier activating enzyme activity [GO:0008641] FCYSIMQLLNHFP;FSRYLRGGAVTE;RKETDDHYFCDGDLVTF 3 4.3 0.99028 -0.53412 6.63212 0 0 0 0 0 0 0 8.95341 0 0 0 0 0 0 A0A8I3PMQ2 A0A8I3PMQ2_CANLF Coiled-coil domain containing 54 CCDC54 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ISSAEPENVPSYPELTDHL 1 5.8 0.98492 -0.25339 0 0 10.5773 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PMQ7 A0A8I3PMQ7_CANLF ESF1 nucleolar pre-rRNA processing protein homolog ESF1 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] DEEEDEDEDSDNDDE;DEEEDEDEDSDNDDES;DEEEDEDEDSDNDDESD;DGNESDEEEDEDEDSDN;DGNESDEEEDEDEDSDNDD;DSDNDDESDSG;EEDEDEDSDNDDESDS;EEEDEDEDSDNDDESDS;EEEDEDEDSDNDDESDSG;EKKRLKKKQKALAE;ESDEEEDEDEDSDND;ESDEEEDEDEDSDNDDES;ESDEEEDEDEDSDNDDESD;GNESDEEEDEDEDSD;KKPLTNNKIESN;NESDEEEDEDEDSDNDDESD;SKKKKKQLMKKKELLE;WEQFLEKKKEKKRLKKKQKALA 18 9.4 0.8578 0.15418 0 7.79623 0 6.4746 6.03338 5.7727 0 4.27806 0 9.36886 8.50795 0 4.82105 6.89458 6.0537 A0A8I3PMS3 A0A8I3PMS3_CANLF Testis expressed 51 TEX51 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATAKLFNHIDET;LEPQYLDQDHM;LFLKRDRVF 3 15.5 0.99142 -0.1823 0 0 0 0 0 7.1151 0 9.92319 0 6.68692 8.85453 10.9286 9.18458 0 0 A0A8I3PMS6 A0A8I3PMS6_CANLF Phosphodiesterase 12 PDE12 Canis lupus familiaris (Dog) (Canis familiaris) "antiviral innate immune response [GO:0140374]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to type II interferon [GO:0071346]; mitochondrial mRNA catabolic process [GO:0000958]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]" mitochondrial matrix [GO:0005759] poly(A)-specific ribonuclease activity [GO:0004535] LIQKELTGYNADLIC;LYYREEAVAEDVLNV 2 4.9 0.9493 0.05391 9.01279 0 0 0 0 0 0 10.1706 0 0 0 0 0 0 0 A0A8I3PMT3 A0A8I3PMT3_CANLF LanC like family member 3 LANCL3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179] plasma membrane [GO:0005886] LCAVCAPVSFLE;LFTEEFKAGSRVLESIYSLYEGFSG;LVHWCHGAP 3 11 1.0021 -0.66916 0 0 0 0 0 0 0 0 11.8741 0 0 0 0 0 12.1648 A0A8I3PMT6 A0A8I3PMT6_CANLF POU domain protein POU4F3 Canis lupus familiaris (Dog) (Canis familiaris) axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PAALTSHPHH 1 3 0.99818 -0.61146 2.83831 0 0 0 0 0 0 0 0 0 4.63674 8.89072 0 0 0 A0A8I3PMU7 A0A8I3PMU7_CANLF G protein-coupled receptor 107 GPR107 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLAAGLQLLPLLGLLQLLA 1 3.4 0.95259 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 6.50187 0 0 A0A8I3PMV6 A0A8I3PMV6_CANLF Transient receptor potential cation channel subfamily M member 8 TRPM8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ligand-gated calcium channel activity [GO:0099604] DTLLRNCDAEVWV;IAAWGMVS 2 10.9 0.98383 -0.25255 0 9.08167 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PMV8 A0A8I3PMV8_CANLF "Mucin 15, cell surface associated" MUC15 Canis lupus familiaris (Dog) (Canis familiaris) LLLIGSHG;NTMTVTPMATEPDEWLTT 2 6.2 0.98948 -0.52093 7.93729 0 0 0 0 0 0 0 0 0 9.45804 0 0 0 0 A0A8I3PMV9 A0A8I3PMV9_CANLF Elongation of very long chain fatty acids protein 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL3) (ELOVL fatty acid elongase 3) (ELOVL FA elongase 3) (Very long chain 3-ketoacyl-CoA synthase 3) (Very long chain 3-oxoacyl-CoA synthase 3) ELOVL3 Canis lupus familiaris (Dog) (Canis familiaris) "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum membrane [GO:0005789] fatty acid elongase activity [GO:0009922] TAEHFFWSLILYATYF;YHHSTVLVYTSFGYKNKVPSGGWFM 2 15.2 0.94507 0.084771 0 0 0 0 0 0 0 10.9169 0 0 0 0 0 0 9.04641 A0A8I3PMW1 A0A8I3PMW1_CANLF G protein-coupled receptor 12 GPR12 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210] VTIGLIVASFSA 1 3.6 0.98494 -0.2577 0 0 0 0 0 0 0 0 13.5269 0 0 0 0 0 0 A0A8I3PMW4 A0A8I3PMW4_CANLF "Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver)" SLC2A2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737] dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]; galactose transmembrane transporter activity [GO:0005354]; glucose transmembrane transporter activity [GO:0005355] FLFVSFFEIGPGPIPWFMV 1 3.6 0.94879 0.04956 0 0 8.29545 0 0 0 0 0 0 0 0 0 0 7.97705 8.16234 A0A8I3PMX5 A0A8I3PMX5_CANLF Protein LLP homolog (Protein LAPS18-like) Canis lupus familiaris (Dog) (Canis familiaris) LKMDGDVLMKD;RAVTGLRVSRF 2 14.2 0.98932 -0.19887 0 0 0 0 0 0 0 0 0 0 0 7.64559 0 0 0 A0A8I3PMY1 A0A8I3PMY1_CANLF Intracisternal A particle-promoted polypeptide IPP Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779] PPQRLLKYI;VLAASSPYFA 2 3.6 1.0036 -1.0639 0 8.48035 0 0 0 0 0 9.67981 0 0 0 0 0 0 0 A0A8I3PMY9 A0A8I3PMY9_CANLF Claudin 18 CLDN18 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cellular response to estrogen stimulus [GO:0071391]; digestive tract development [GO:0048565]; epithelial cell proliferation [GO:0050673]; epithelial fluid transport [GO:0042045]; lung alveolus development [GO:0048286]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast development [GO:2001205]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; organ growth [GO:0035265]; protein localization to nucleus [GO:0034504] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] GIMFIISGLCAIV;VFQYEGLWRSCVRQ 2 10.3 0.90795 0.12068 10.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PMZ4 A0A8I3PMZ4_CANLF Chordin like 1 CHRDL1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; negative regulation of BMP signaling pathway [GO:0030514] extracellular space [GO:0005615] BMP binding [GO:0036122] GLFQNRQPNQCTQCSCSEGN;KRMFEELH;VGERWHPYLEPYGL;WEHSDGDIFRQPANRE 4 13.6 0.98751 -0.35096 0 0 0 0 0 5.36692 0 0 7.47362 0 0 0 0 8.60073 0 A0A8I3PMZ9 A0A8I3PMZ9_CANLF "Carboxypeptidase X, M14 family member 2" CHST15 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] metallocarboxypeptidase activity [GO:0004181]; sulfotransferase activity [GO:0008146]; zinc ion binding [GO:0008270] EDFQKEDGTVNGASWH;MVRSMWKTQEHSPTPDDHVFRWLAY;RIVRLVEETRIHILPSLNPD;RLKLRGRK;SDGKEHHHQPSVNN;YEGGSELGGWSLGRWTHDGI 6 8.9 0.99781 -0.59966 7.01892 10.318 10.0013 0 0 0 0 0 0 0 0 0 0 0 7.85929 A0A8I3PN03 A0A8I3PN03_CANLF Sterile alpha motif domain containing 7 SAMD7 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of gene expression, epigenetic [GO:0045814]; retinal rod cell development [GO:0046548]" cytoplasm [GO:0005737]; PRC1 complex [GO:0035102] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]" FNSWGDNTLDIPCSHD;VLPNANMPNML 2 6 0.98806 -0.48943 0 8.94977 0 12.1096 0 0 9.79635 0 0 0 0 0 0 0 0 A0A8I3PN12 A0A8I3PN12_CANLF Phospholipid scramblase PLSCR5 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid scramblase activity [GO:0017128] SLPNPGNQVW 1 3.7 0.98891 -0.26139 0 0 0 0 0 0 9.78598 0 0 0 0 0 0 0 0 A0A8I3PN21 A0A8I3PN21_CANLF Homeobox protein PITX3 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASLPGGSPEDGSL;QELEATFQ;VPGPPPAA 3 9.6 0.94057 0.059797 0 0 0 0 0 0 0 0 0 10.9565 0 0 0 0 0 A0A8I3PN24 A0A8I3PN24_CANLF Epithelial cell transforming 2 ECT2 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; nervous system development [GO:0007399]; regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431]" cell cortex [GO:0005938]; nucleus [GO:0005634] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] RPPASLKHVHLMPL;SVFNELHKMDH 2 2.9 0.99442 -0.56255 0 0 0 0 0 10.1378 0 0 0 0 0 0 0 0 0 A0A8I3PN28 A0A8I3PN28_CANLF KLF transcription factor 5 KLF5 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell-cell signaling via exosome [GO:0099156]; cellular response to leukemia inhibitory factor [GO:1990830]; intestinal epithelial cell development [GO:0060576]; microvillus assembly [GO:0030033]; myotube differentiation involved in skeletal muscle regeneration [GO:0014908]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by transcription factor localization [GO:0061586]; regulation of microvillus assembly [GO:0032534]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell differentiation [GO:0014816] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; MRF binding [GO:0043426]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IFSHQSETTAPPPAPTQA;TEPVTIFSHQS;TGEKPYKCTWEGC;VLGAANPARDAALFP 4 11.2 0.995 -0.154 0 0 0 0 0 0 0 0 11.0319 0 0 0 0 0 0 A0A8I3PN32 A0A8I3PN32_CANLF G protein subunit alpha z GNAZ Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188] heterotrimeric G-protein complex [GO:0005834] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] KIRRIPLTICFPE;YEDNQTSRMAES 2 7 0.91626 0.11016 8.43208 0 8.12841 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PN50 A0A8I3PN50_CANLF Chromosome 4 open reading frame 17 C32H4orf17 Canis lupus familiaris (Dog) (Canis familiaris) NDDENALGTLWG;TAGSCSSE 2 7 1.0021 -1.239 0 11.2152 0 0 0 0 5.11378 0 0 0 0 0 0 0 0 A0A8I3PN54 A0A8I3PN54_CANLF BLOC-1-related complex subunit 7 CNNM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YGCGLVIPECL;YQQEAIQKKYYGC 2 4.9 0.94432 0.059632 0 0 0 0 0 0 0 0 0 0 0 9.37184 0 0 0 A0A8I3PN72 A0A8I3PN72_CANLF Calcipressin-1 (Regulator of calcineurin 1) RCAN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722] nucleic acid binding [GO:0003676] ESETRAKFE;GPGEKYELH;VHVCESDQENEEDDEAE 3 17.8 1.0026 -0.75799 9.35445 0 0 0 0 0 0 0 8.89303 0 0 0 0 0 0 A0A8I3PN76 A0A8I3PN76_CANLF Ras protein specific guanine nucleotide releasing factor 2 RASGRF2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DIKKIKKVQ;SETIMFLHEIF;SGRPAGMYLLE;SKLHSDWTLFLSGPDIL 4 8.5 0.97763 0.046227 0 0 0 0 0 0 0 7.50795 0 0 0 0 0 0 0 A0A8I3PN88 A0A8I3PN88_CANLF DDB1 and CUL4 associated factor 15 DCAF15 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; regulation of natural killer cell activation [GO:0032814] Cul4-RING E3 ubiquitin ligase complex [GO:0080008] small molecule binding [GO:0036094] EVPPALPSPCPEAAP;LVPESSGRYVNRM;LVRQVRLFQDEEIYSDLYLTVCEW;MLMNMMMMSDENHRDIYI;SRCRLPSEPLAPGGE 5 14.2 0.99233 -0.19166 0 11.3292 0 0 0 0 0 0 0 10.1015 4.37518 5.23688 0 0 9.04325 A0A8I3PNA4 A0A8I3PNA4_CANLF ADAM metallopeptidase domain 8 ADAM8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AGAECAQGACCREC;CWKGLCQQL;LEGGGEEVQ;PASPPCPRQL;QPARPMASTATPKQP;YQELDFRVFLV 6 8.2 1.0032 -1.5598 0 0 0 0 0 0 8.16988 10.4019 8.89057 0 0 0 0 0 0 A0A8I3PNB1 A0A8I3PNB1_CANLF Olfactory receptor family 6 subfamily C member 3I LOC119871298 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TISYNDSAVQLFFFILM;VALLFTLALVILSYLYIIRTILRI 2 13.1 0.99488 -0.12605 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.0848 A0A8I3PNB2 A0A8I3PNB2_CANLF Family with sequence similarity 98 member B FAM98B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; tRNA-splicing ligase complex [GO:0072669] identical protein binding [GO:0042802]; protein methyltransferase activity [GO:0008276] GGGGGGSG;GGRGGGGG;KDRLKKKDDCL;WGGGGGGG 4 6.8 0.98014 0.035491 0 0 0 0 0 0 0 8.25555 8.17173 0 0 0 0 0 0 A0A8I3PNB7 A0A8I3PNB7_CANLF Potassium voltage-gated channel subfamily C member 2 KCNC2 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] EPCCWMTYRQHRDAEEALDIFE;GAGGGGGG;GGGGGGGG;GVCVVWFTFEFLV;LTIAMPVPVIV;VVRFVRILRIFKLTRHFV 6 12.8 0.93879 0.059719 0 0 0 0 0 0 0 9.7526 0 0 0 0 0 0 0 A0A8I3PNB9 A0A8I3PNB9_CANLF Potassium voltage-gated channel subfamily H member 8 KCNH8 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] voltage-gated potassium channel activity [GO:0005249] DLIAALPFDLL;ELLKDFPDELRSDIT;HLLKTVRLLRLLRLL;IVEDEEEEEEGEDEE;KRLESPYYGNNTL;KTVRLLRLLRLLQKLD;LVHLLKTVRLLRLLRLLQKL;PSIVEDEEEEEEGED;RLLRLLRLLQK;SLVHLLKTVRLLRLLRL;TVRLLRLLRLLQ;TVVSLVHLLKTVRLLRLLR;TVVSLVHLLKTVRLLRLLRL;VHLLKTVRLLRLLRLLQKLDRYSQ 14 7.7 0.51445 0.4596 0 5.76447 8.03941 0 8.30811 6.08326 9.97943 10.633 3.45457 0 0 4.36485 5.945 0 9.6025 A0A8I3PNC0 A0A8I3PNC0_CANLF Rho GTPase activating protein 25 ARHGAP25 Canis lupus familiaris (Dog) (Canis familiaris) "actin filament organization [GO:0007015]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; phagocytosis, engulfment [GO:0006911]; signal transduction [GO:0007165]" phagocytic cup [GO:0001891] GTPase activator activity [GO:0005096] DPFECILE;DSFSNTVRCRENS;TPSGAVFGQRLDETVAY 3 8.5 1.0016 -0.70905 0 0 0 4.42808 0 0 0 0 0 0 0 0 0 11.0069 0 A0A8I3PNC4 A0A8I3PNC4_CANLF C-type lectin domain-containing protein LOC119868927 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] carbohydrate binding [GO:0030246] INFNDIQELC;LPASLDEELQTTLHDL;SGDFQYMDGAPVN;TPGSHGLPGRDGRDGVKGDP 4 23.9 1.0015 -0.64101 0 0 0 0 9.96412 0 0 0 0 8.16435 0 0 0 0 6.90653 A0A8I3PND5 A0A8I3PND5_CANLF Basic helix-loop-helix family member e41 BHLHE41 Canis lupus familiaris (Dog) (Canis familiaris) circadian regulation of gene expression [GO:0032922]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by competitive promoter binding [GO:0010944] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; MRF binding [GO:0043426]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" EQQHQKIIALQNGERS;FGGGGGAP;FYFLSPSA;GGGGGGGG;GLGGGGGGL;HRLIEKKRRD;KGKGSGAG;LDAFHSGFQTCAKEVLQ;SRGGGGGGG 9 17.2 0.95581 0.049233 0 0 0 0 0 0 0 0 10.744 0 0 0 0 0 0 A0A8I3PND7 A0A8I3PND7_CANLF "Alpha-1,4-N-acetylglucosaminyltransferase" A4GNT Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell proliferation [GO:0050673]; negative regulation of epithelial cell proliferation [GO:0050680]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] acetylglucosaminyltransferase activity [GO:0008375] PFLWECMENFVEHYNSEI 1 5 0.97118 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.07 0 0 A0A8I3PND8 A0A8I3PND8_CANLF IF rod domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ERKVESLQEEIAFL;ESLQEEIAFL;KRTLLIKRLKLGMDRL;LSEAASRNN;QIDMDNLQEGAEWYRPE;VQIDMDNLQ 6 13.9 1.0031 -2.338 12.5934 0 0 0 0 5.91064 0 13.3509 6.7416 8.49121 0 0 0 0 12.9436 A0A8I3PND9 A0A8I3PND9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;IQPFKIFGMQQK;MDAFLESHKL;MNEKGEITTNT 4 6.3 0.99147 -0.27579 0 0 15.0585 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PNE4 A0A8I3PNE4_CANLF XK-related protein XKR4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AAGGGCCPDGGGCSRCCCCCAGSG;AEDEEAAGGGCCPDGGGCSRCCCCC;AGGGCCPDGGGCSRCCCCCAGSG;CCCCAGSGGSGG;CCCCCAGS;CCCCCAGSGGS;CCCCCAGSGGSGGGSGGGSGGG;CCPDGGGCSRCCCC;CCPDGGGCSRCCCCC;CCPDGGGCSRCCCCCA;CPDGGGCSRCCCCC;CPDGGGCSRCCCCCA;CSRCCCCCAGSGGSGGGSGG;DEEAAGGGCCPDGGGCSRCCCCCA;DGGGCSRCCCCCAGSGGSGGGSGG;EAAGGGCCP;EDEEAAGGGCCPDGGGCSRCCCCC;EDEEAAGGGCCPDGGGCSRCCCCCA;GCCPDGGGCSRCCCCCAGSG;GCCPDGGGCSRCCCCCAGSGG;GGCCPDGGGCSRCCC;GGCCPDGGGCSRCCCCC;GGCSRCCCCCAGSGGSGGGSGGG;GGGCCPDGGGCSRCCCC;GGGCSRCCCCCAGSGGSGGGSGG;PGGPGGGG;RCCCCCAGSGGSGGGSG;SRCCCCCAGSGGSGGGSGG;TDIWLAVDYY;VLHWCIMTF;VQGLAPGLPSGSGAED 31 12.4 0.99691 -4.3817 0 7.30898 0 8.44108 10.4464 10.3594 7.23869 8.1821 6.3957 9.03012 5.62337 9.19552 10.2201 6.44346 6.44554 A0A8I3PNE7 A0A8I3PNE7_CANLF Eukaryotic initiation factor 4A-II (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) EIF4A2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830] perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] DIETFYLNLV 1 2.5 0.99847 -0.61146 0 0 0 0 0 0 0 0 0 0 0 11.9637 0 0 0 A0A8I3PNF2 A0A8I3PNF2_CANLF Podocan like 1 PODNL1 Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] LDLQVFPDNITRAAQHLSLQNN;LDQLRELSLAHN;LLLLLLLL;LLLLLLLLP;LLLLLLLP;PEAFLGLLHLR;RNRIRWVEAARL 7 11.5 0.99399 -0.11867 0 0 0 0 8.14843 0 0 0 11.4468 0 0 0 0 11.568 0 A0A8I3PNF4 A0A8I3PNF4_CANLF Solute carrier family 43 member 3 SLC43A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] LVSTYTNAFAI 1 2.3 0.98139 0.035491 0 0 0 0 9.14858 0 0 0 0 0 0 8.60433 0 0 0 A0A8I3PNG1 A0A8I3PNG1_CANLF Protein arginine methyltransferase 3 PRMT3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] metal ion binding [GO:0046872]; protein-arginine N-methyltransferase activity [GO:0016274] AAWEDDDEDEDG;DSGDEAAWEDDDEDEDGAGA;LPELSDSG;NCHSRVVFSTGP 4 6.9 0.98972 -0.27371 0 0 8.52904 6.32422 0 0 5.31575 0 0 0 0 0 0 0 0 A0A8I3PNH1 A0A8I3PNH1_CANLF NK6 homeobox 2 NKX6-2 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system myelination [GO:0022010]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of oligodendrocyte differentiation [GO:0048715]; neuromuscular process controlling balance [GO:0050885]; neuron fate commitment [GO:0048663]; pancreatic A cell differentiation [GO:0003310]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PPIFWPGVVQGSPWRDP;TESQVKVWFQ 2 9.8 0.9843 -0.23816 0 0 0 0 0 0 0 0 10.1783 0 0 0 0 0 0 A0A8I3PNH5 A0A8I3PNH5_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein LOC119869220 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EPSPTQQEGPAH;FHKIRSRIVQRTPKTKKSKKFRK;NNKLILAISVTVVVMILIIV;PKAKNVRRGRFRKNRVLKGPK 4 7.7 0.97605 0.047166 0 0 0 0 0 0 6.13683 0 0 0 0 0 0 0 0 A0A8I3PNI6 A0A8I3PNI6_CANLF WD repeat and FYVE domain containing 3 WDFY3 Canis lupus familiaris (Dog) (Canis familiaris) aggrephagy [GO:0035973] Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; inclusion body [GO:0016234]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; PML body [GO:0016605] 1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872] DEDSSDSEADEQSTSQDPKDV;DEGGDSCSGC;EAQIGQEAQDEDSS;EQEEKLYMMLPVFNRVFGNA;GEKIQHMYRCARVQ;GRSTVREINRDACHFPGFPVLQ;LITSMEGLGS;NLILLRNRLLDILLKL;QEEKLYMMLP;QLLIKAVNRVWTELIHSKKQALE;QPEHALDLQLAV;QVSVPVISSRCKQGCQFDLDSIWTF;SMDTVSPTLRHCSKLFIYL;VISMDTVSPTLRHC;VLTVNRNLILGPG 15 6.1 1.0018 -1.4081 0 11.8383 0 8.70193 0 0 7.71363 7.23879 10.0677 0 0 4.61565 0 11.3388 5.11765 A0A8I3PNI8 A0A8I3PNI8_CANLF Eukaryotic initiation factor 4A-I (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] VGTPGHVFDMLNR 1 4.5 0.98727 -0.23439 0 0 0 0 0 0 0 0 10.3096 0 0 0 0 0 0 A0A8I3PNJ3 A0A8I3PNJ3_CANLF Reticulocalbin 3 RCN3 Canis lupus familiaris (Dog) (Canis familiaris) collagen biosynthetic process [GO:0032964]; ERAD pathway [GO:0036503]; lung epithelium development [GO:0060428]; phospholipid homeostasis [GO:0055091]; protein secretion [GO:0009306]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; surfactant homeostasis [GO:0043129] endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509] LLLLLLLL;PSLLLLLLLLR 2 3.4 0.98122 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 4.32459 0 A0A8I3PNJ4 A0A8I3PNJ4_CANLF Lysosomal-associated transmembrane protein 4B LAPTM4B Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886] PNSIQEYIRQLPPN 1 6.9 0.93741 0.060873 0 0 0 0 9.76265 0 0 0 0 0 0 0 0 0 0 A0A8I3PNK5 A0A8I3PNK5_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WYQQQQPGKAPRYLM 1 15.6 0.9505 0.053874 0 0 0 8.34833 9.01762 0 0 0 0 10.4834 4.36695 0 0 0 4.24481 A0A8I3PNK6 A0A8I3PNK6_CANLF 60S ribosomal protein L29 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VEASVCQCEDGRTGMTPGL 1 25.7 0.98938 -0.19666 0 0 0 0 0 0 0 0 9.45896 0 0 0 0 0 0 A0A8I3PNL6 A0A8I3PNL6_CANLF Tetratricopeptide repeat domain 39D TTC39D Canis lupus familiaris (Dog) (Canis familiaris) KNLDNIKN;LVLEQCIFIQNEWKQ;LVLEQCIFIQNEWKQFHHLCYW 3 5.1 1.0022 -1.3073 0 11.6137 0 0 0 0 0 0 0 0 0 0 0 7.47086 0 A0A8I3PNM2 A0A8I3PNM2_CANLF Keratin associated protein 22-1 KRTAP22-1 Canis lupus familiaris (Dog) (Canis familiaris) CCYGRFWSSGFF;GGLGCGYG 2 45.5 0.9459 0.05044 0 0 0 0 0 0 0 0 0 0 8.12717 0 0 0 0 A0A8I3PNM4 A0A8I3PNM4_CANLF Neuropeptides B and W receptor 1 NPBWR1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of metabolic process [GO:0019222] plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188] ADELFTLVLPINIADFLLQQW;CLLCWTPYHLSTVV 2 10.6 0.99281 -0.17924 0 0 0 0 0 0 0 0 0 0 0 11.2797 0 5.54201 0 A0A8I3PNM6 A0A8I3PNM6_CANLF Ornithine decarboxylase antizyme 3 OAZ3 Canis lupus familiaris (Dog) (Canis familiaris) viral translational frameshifting [GO:0075523] ornithine decarboxylase inhibitor activity [GO:0008073] AFSAPESLA;DRGALLRAFSYMGFELVRPD;QDPVQLDFHFRLTPQ;VEEKTNVDSV 4 28.1 0.98961 -0.52608 9.45306 0 0 0 0 0 0 0 0 0 0 12.2395 0 0 0 A0A8I3PNM7 A0A8I3PNM7_CANLF Retinoic acid receptor RXR (Nuclear receptor subfamily 2 group B member) RXRG Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear steroid receptor activity [GO:0003707]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] QSERLMLDIFLSLAEDEVARQ 1 3.7 0.94893 0.050165 0 0 0 0 0 0 0 0 8.87458 0 0 0 0 0 0 A0A8I3PNM9 A0A8I3PNM9_CANLF Armadillo repeat containing X-linked 5 ARMCX5 Canis lupus familiaris (Dog) (Canis familiaris) AEHSDPEIHLQ;EDDIKFRAEAGDRA;IPPYKGPYFQTLA;LVAPFNKNE;PLGIRPLTKIPP;QEKPKPIPKPELTIK 6 14.4 1.002 -0.67823 0 0 9.78885 0 0 0 8.75064 0 9.10596 5.77442 9.32679 0 0 0 0 A0A8I3PNN3 A0A8I3PNN3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IVLRILKIFSVN;LETMGYIS;TYIVLRIL 3 10.1 0.95576 0.05044 0 0 0 0 6.60477 0 0 0 0 0 0 0 0 0 0 A0A8I3PNP0 A0A8I3PNP0_CANLF Basic helix-loop-helix family member e41 BHLHE41 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] FGGGGGAP;FYFLSPSA;GGGGGGGG;GLGGGGGGL;HRLIEKKRRD;KGKGSGAG;LDAFHSGFQTCAKEVLQ;LVNRSLKSPIQ;SRGGGGGGG 9 17.4 0.99731 -3.444 8.07066 0 0 10.5094 0 0 0 9.35632 10.7314 11.945 11.775 0 9.74357 10.2719 14.4061 A0A8I3PNP2 A0A8I3PNP2_CANLF "Proteasome 26S subunit, non-ATPase 9" PSMD9 Canis lupus familiaris (Dog) (Canis familiaris) proteasome regulatory particle assembly [GO:0070682] cytoplasm [GO:0005737]; nucleus [GO:0005634] WAGKGLLGCNI 1 9.3 0.98583 -0.24596 0 0 0 0 0 0 0 0 0 10.253 0 0 0 0 0 A0A8I3PNP3 A0A8I3PNP3_CANLF Keratin 75 KRT75 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] EIDNLKKQC;EVKAQYEDIANRS;GACGGAGF;GGFGLGGG;GGYGGRVGGGF;GVGPVNISVVSSSGGTGYS 6 12.3 1.0032 -2.1316 10.0366 0 7.70736 0 0 0 0 0 0 10.1217 0 0 0 0 0 A0A8I3PNP4 A0A8I3PNP4_CANLF RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) ALKBH5 Canis lupus familiaris (Dog) (Canis familiaris) gamma-delta T cell proliferation [GO:0046630]; mRNA destabilization [GO:0061157]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; non-membrane-bounded organelle assembly [GO:0140694]; regulation of translation [GO:0006417]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; paraspeckles [GO:0042382] metal ion binding [GO:0046872]; molecular condensate scaffold activity [GO:0140693]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931] ITHCIRPQDIKERRAVIIL;YESGEDCSEAAGSP 2 8.4 0.99311 -0.27984 0 0 0 0 0 0 0 0 0 0 0 3.49031 0 0 0 A0A8I3PNP5 A0A8I3PNP5_CANLF Piwi-like protein 2 PIWIL2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] cytoplasm [GO:0005737] RNA binding [GO:0003723] GPAQRESVGFV;TRDLSILTVPMHFWALF;VGRNFYDP;VGSLKKFY;VLDVMHAIYQQNKENFQ 5 6.5 1.0031 -2.413 0 0 0 0 0 0 0 0 10.6633 7.43979 0 0 11.5551 8.56285 0 A0A8I3PNQ0 A0A8I3PNQ0_CANLF Placenta enriched 1 PLAC1 Canis lupus familiaris (Dog) (Canis familiaris) placenta development [GO:0001890] extracellular region [GO:0005576] LASVFSAC;QPHVYQFTYRV 2 9 0.98779 -0.22947 0 0 0 0 0 0 0 0 12.6064 0 0 0 0 0 9.35746 A0A8I3PNR8 A0A8I3PNR8_CANLF Cysteine-rich protein 2 CRIP2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GVWGGTAG;LGARGGAAPRGAA;TVLLLLPLPV 3 4.5 1.0034 -1.0698 0 0 0 4.80364 0 0 9.84224 0 0 0 0 9.65923 0 0 0 A0A8I3PNS2 A0A8I3PNS2_CANLF C-type lectin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YYSPEEMNNQ 1 3.6 0.99928 -0.61146 0 0 0 0 5.55281 0 0 0 0 0 0 0 0 0 0 A0A8I3PNS4 A0A8I3PNS4_CANLF Proline rich 12 PRR12 Canis lupus familiaris (Dog) (Canis familiaris) AAAYATGKASGAGGAG;CGETDEEAGESGGEG;CPSPCKRLDEELKRNL;GAGGGGGG;GHGGGWGP;PAGEPYNR;PLTSICFPDSL;PWLEQLFDSFSDLLAQ;VLGPAGLGP 9 5.4 0.99428 -0.025768 0 0 0 0 0 0 0 0 0 10.3224 0 0 0 0 0 A0A8I3PNT1 A0A8I3PNT1_CANLF mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] mRNA 5'-cap (guanine-N7-)-methyltransferase activity [GO:0004482]; RNA binding [GO:0003723] HYNELQEVGLENVLIGEFLEKVRQ;KDEPSTGDDTQK;VVDVPEFLVYFPLLNE 3 11.9 0.98751 -0.37789 0 0 10.4611 0 0 0 0 0 9.42826 0 0 0 0 0 0 A0A8I3PNU5 A0A8I3PNU5_CANLF Kinase (EC 2.7.-.-) IP6K1 Canis lupus familiaris (Dog) (Canis familiaris) inositol phosphate biosynthetic process [GO:0032958]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854] cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] inositol hexakisphosphate kinase activity [GO:0000828] EAGPSSPP;ESETVEQDDTPEREQPRRKHSRR;LENVVHHFKYP;STSATLGVRVCGMQV 4 12.9 0.98657 -0.41044 9.16506 0 0 0 0 10.6016 0 8.35103 0 0 7.89639 0 0 9.25635 0 A0A8I3PNW6 A0A8I3PNW6_CANLF Hemicentin 2 HMCN2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AQDAGAYICT;ASQHYIVQ;GEILDLNCMAEGSPEP;GVALQGGGP;GVSNIDFRAGFSTQ;KDHEGNPL;LDCEAQGSPPPLVT;VLSAVPYNLTWIRDWR;VTNTAGSQHRDVEL;VVTVSQTSLRPST 10 8.5 0.99663 -0.11283 0 0 0 0 0 0 0 0 0 0 0 0 9.78836 0 0 A0A8I3PNX1 A0A8I3PNX1_CANLF Neurofascin NFASC Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AGAAGAAAAAAAADGTDCARGRS;GAAAAAAAADGTDC;LTDLAERSVRLTWIPGN;RQQASFPGDRPRG;RTSGAPPESNPA;SLQWNRVYPDTVQ 6 6.1 1.0039 -1.0602 0 6.96151 0 0 0 0 0 9.38647 7.94498 0 0 0 0 0 0 A0A8I3PNX5 A0A8I3PNX5_CANLF Ankyrin repeat and EF-hand domain containing 1 ANKEF1 Canis lupus familiaris (Dog) (Canis familiaris) HEKVRGGG;ITSGHTKKVDI;KLKGKPPPKVKSEG;LATIAQFHEKVRGGGVNI;NVNATDNFL;TCLTFLEKGANPN 6 8.4 1.0018 -0.64806 0 7.28522 8.23036 10.0412 0 0 10.5262 0 0 0 0 0 0 8.25857 0 A0A8I3PNX7 A0A8I3PNX7_CANLF Nucleolin NCL Canis lupus familiaris (Dog) (Canis familiaris) "angiogenesis [GO:0001525]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to leukemia inhibitory factor [GO:1990830]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of translation [GO:0017148]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]" cell cortex [GO:0005938]; chromosome [GO:0005694]; cornified envelope [GO:0001533]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681] DNA topoisomerase binding [GO:0044547]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; mRNA 5'-UTR binding [GO:0048027]; PH domain binding [GO:0042731]; telomeric DNA binding [GO:0042162] AAAPASDEEEDDE;AAAPASDEEEDDEEDDDE;AAAPASDEEEDDEEDDDEDDDEE;AAPASDEEEDDEEDDDEDDDE;DDDEDDDEEDEDEDEDDSE;DDEDDDEEDEDEDEDDS;DDEEDEDEDEDDSEEAAMET;DDSEEEDEEDEDEDEDEFE;DEDDDEEDEDEDEDDSEEA;DEDEEDDDEEEEDEDDDEE;DEEDDDDS;DSEDEEMSEDEDDDSSGE;EDDDEDDDEEDEDEDEDDSE;EDDDEEDEDEDEDDSEEAAME;EDDEDEEDDDEEEEDEDDDEE;EDSDEEDDDDSEEEDEE;EDSEDEEMSEDEDDDSS;EEDDDDSEEEDEEDEDE;EEDDDDSEEEDEEDEDEDEDEF;EEDEEDEDEDEDEF;EEDEEEEEEEEEEEPVKEAPG;IVTDRETGSSKGF;KEDSDEEDDDDSEEE;KEDSDEEDDDDSEEEDEEDEDEDE;KGIAYIEFKTEADA;PASDEEEDDEEDDDE;PASDEEEDDEEDDDEDDDEEDED;PPPKEVEEDSEDEEMSEDEDDDSS;SDEEEDDEEDDDEDDD;SEEEDEEDEDEDEDEFE;TAEDEDEEEDDED;TAEDEDEEEDDEDEE 32 23.6 0.86438 0.14478 0 0 0 0 0 0 0 0 0 0 0 4.18015 3.84358 0 7.91187 A0A8I3PNY5 A0A8I3PNY5_CANLF SUMO specific peptidase 1 SENP1 Canis lupus familiaris (Dog) (Canis familiaris) protein desumoylation [GO:0016926]; proteolysis [GO:0006508] nucleus [GO:0005634] deSUMOylase activity [GO:0016929] IADRMRMDAGE;LHQPQHHHSLLYQPD;NSRSLYLET;QEHSVHDSVELHLR 4 7.6 1.0025 -1.1291 0 0 0 11.33 0 9.32688 0 0 0 0 0 0 7.46508 0 0 A0A8I3PNY7 A0A8I3PNY7_CANLF Neurofascin NFASC Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AGAAGAAAAAAAADGTDCARGRS;GAAAAAAAADGTDC;LRVYSRDKEGISSTVIT;LTDLAERSVRLTWIPGN;RTSGAPPESNPA 5 5.5 0.97748 0.046227 0 0 7.46703 0 0 0 0 0 0 0 0 0 0 0 7.25323 A0A8I3PNY9 A0A8I3PNY9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MAEVAGPT 1 2.8 1.0042 -1.1044 0 0 0 0 0 0 0 10.1495 0 0 0 0 0 0 0 A0A8I3PNZ3 A0A8I3PNZ3_CANLF Ig-like domain-containing protein LOC119868972 Canis lupus familiaris (Dog) (Canis familiaris) ELTASQTIVYPDE;LEVSQHPTARDQ;NFTCKSHGFSPRNITL 3 10.2 0.91762 0.11333 0 8.81279 9.38681 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PNZ4 A0A8I3PNZ4_CANLF Membrane bound O-acyltransferase domain containing 2 MBOAT2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] NFRHYFIEPPQLK;TQKITSLAYEIHD 2 3.1 0.87588 0.12687 0 0 9.79946 0 0 0 0 0 6.47709 0 0 0 0 0 9.98157 A0A8I3PP26 A0A8I3PP26_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] RNRVMPCHFSRGSKSLARRVPQALE 1 35.2 0.98998 -0.21374 9.96665 10.0001 0 10.0614 0 0 11.132 11.1128 11.3476 0 0 0 0 10.7625 0 A0A8I3PP46 A0A8I3PP46_CANLF Vacuolar fusion protein MON1 homolog MON1A Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192] Mon1-Ccz1 complex [GO:0035658] guanyl-nucleotide exchange factor activity [GO:0005085] EEEQERLLGL;KRSSECPDGTLAPS;RKEEDRLFILT 3 6.3 0.99454 -0.15457 10.8323 10.1008 4.47138 0 0 0 0 0 0 8.07184 11.0906 0 0 0 0 A0A8I3PP66 A0A8I3PP66_CANLF Insulin-like growth factor-binding protein 5 IGFBP5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of insulin-like growth factor receptor signaling pathway [GO:0043567] extracellular space [GO:0005615] fibronectin binding [GO:0001968]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995] EPGCGCCMTCA;GAENTAHPRVISAPE;KEPGCGCCMTC 3 10 0.99458 -0.12881 7.5227 0 0 0 0 0 0 0 0 0 5.4455 0 0 0 0 A0A8I3PP67 A0A8I3PP67_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] ANLWTQTEDDLITQWT;ASKVMPWTQSEPPTLNPWTDI;EVDATRLPSWTQTAT;EVSPWRDTVSNSVTQG;KSERDKVRTWT;LLSIYPGINSVNTWSLPKFET;LQVSTCAQFWPKLNEF;LSWMRWLI;LVNSWSEADVS;MWTEPVTQTIHHRIQ;PKGPLGPG;PWTETIGSRFTPWTQPLPP;SETHTLTTWTLTESLVEN;SETLVLSG;SPAVNPWIEPV;TENQVVKPPTLPEIDTITSWLQ;TLTESTEVSPWRDTV;TPIAGTSETLVLSGPP;TTWTLTESLVEN;VIPWNQAESTTI;VTIWTQEETPGVNLWKQ;WKEDFSSRLMPWNQAVPPVVNP 22 6.5 0.99704 -4.0536 10.613 12.1436 8.33333 0 10.9814 8.13535 0 9.64573 9.37467 9.10881 9.05501 9.29877 8.0393 10.2054 8.02431 A0A8I3PP68 A0A8I3PP68_CANLF Solute carrier organic anion transporter family member 5A1 SLCO5A1 Canis lupus familiaris (Dog) (Canis familiaris) sodium-independent organic anion transport [GO:0043252] membrane [GO:0016020] sodium-independent organic anion transmembrane transporter activity [GO:0015347] DNVKKENASLYLAIMYVMGAL;IFLAWYSIKYKEDE;ISPPYQIQ;RYSLKSSESGLLVSCFDIGSL;VIFPMFTFPKKLPPRHKKKKKKKF;VLTDSRCFLVCMCFLTFIQALMVSG 6 14.2 0.98618 -0.45472 0 0 0 7.52356 0 0 0 10.1903 0 0 0 0 10.1908 10.8463 0 A0A8I3PP75 A0A8I3PP75_CANLF Cytochrome P450 family 2 subfamily R member 1 LOC119865014 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" AASGELAHVYM;DQGKNDPSCTFSKENLIFSVGE;IETYKGRPFDLK;VYMRKQSRVYGEIFSLD 4 12.3 0.98823 -0.3419 0 0 6.19592 0 0 0 0 0 6.44392 8.81548 0 0 0 0 0 A0A8I3PP79 A0A8I3PP79_CANLF Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DUSP9 Canis lupus familiaris (Dog) (Canis familiaris) MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] NLPNLFEKNGDFHYKQIPISD;VALPALLLRRLRRGSL 2 9.7 0.93324 0.096991 0 0 0 0 0 0 0 6.41515 0 0 0 0 0 8.98701 0 A0A8I3PP85 A0A8I3PP85_CANLF peptidyl-tRNA hydrolase (EC 3.1.1.29) PTRHD1 Canis lupus familiaris (Dog) (Canis familiaris) aminoacyl-tRNA hydrolase activity [GO:0004045] EQPENIATCIALR 1 9.3 0.94358 0.061776 0 0 0 0 0 0 0 0 0 0 6.04505 0 0 0 0 A0A8I3PP98 A0A8I3PP98_CANLF Protein NDNF NDNF Canis lupus familiaris (Dog) (Canis familiaris) cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of neuron apoptotic process [GO:0043524]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]; response to ischemia [GO:0002931]; vascular wound healing [GO:0061042] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] heparin binding [GO:0008201] CIYKKEVDDNYNEDQKKRE;SATVAWLGTQERNKFCIYKKEVDD 2 6 0.93417 0.091146 0 0 0 8.06156 8.39253 0 0 0 0 0 0 0 0 0 0 A0A8I3PPA0 A0A8I3PPA0_CANLF Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase) PTGIS Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; prostaglandin-I synthase activity [GO:0008116]" AALLLLLLLSRRRTRRP;PTLLHKDLQALTDSM;RRTRRPGEPPL;TTLPQKLLDNMPVLDS;YAISSIKQFV 5 12.6 0.98007 0.046227 0 0 0 5.29241 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PPA2 A0A8I3PPA2_CANLF Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP) NOSIP Canis lupus familiaris (Dog) (Canis familiaris) regulation of nitric oxide biosynthetic process [GO:0045428] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] molecular sequestering activity [GO:0140313]; ubiquitin protein ligase activity [GO:0061630] EREAILEYILHQKKEI;MECVEKLIRKDMVDPVN 2 7.9 0.92644 0.09546 8.89309 0 0 0 0 0 0 0 0 0 0 0 0 6.07769 0 A0A8I3PPA3 A0A8I3PPA3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) KALRN Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; habituation [GO:0046959]; lactation [GO:0007595]; maternal behavior [GO:0042711]; maternal process involved in parturition [GO:0060137]; memory [GO:0007613]; negative regulation of growth hormone secretion [GO:0060125]; neuromuscular junction development [GO:0007528]; positive regulation of dendritic spine morphogenesis [GO:0061003]; social behavior [GO:0035176] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine/threonine kinase activity [GO:0004674] DAEKMFDWIS;DLELAIHHH;DNKTVLKASNIETKQEW;DQNILDTDNSSATY;DWHKDFFLAE;ELRLSLEEFFN;EQDRLAQLFIKHERKLH;EVFLKYIHRNNVSMPS;KDFLRYSEK;LFHERKIKLDIFLQLRIF;LLIDLRIPVPRVKLIDLEDAVQI;SSEESECDDLDPNTS;VGKSLHRA;VGKSLHRARAL;VLETQRDFLNALQSP;VRLHQRLQLCVF 16 7.1 0.9999 -2.8243 10.9039 13.9349 14.1863 13.2658 9.58214 9.72894 14.2971 11.1621 0 14.4975 6.92754 11.732 13.9612 0 11.1229 A0A8I3PPA9 A0A8I3PPA9_CANLF 40S ribosomal protein S8 RPS8 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" cytosolic small ribosomal subunit [GO:0022627] structural constituent of ribosome [GO:0003735] VRTKTLVKNCIVLID;YHKKRKYELGRPAANTKIGPRRIH 2 18.8 0.99151 -0.27003 0 0 0 0 0 0 0 0 6.19763 0 0 0 0 0 0 A0A8I3PPB1 A0A8I3PPB1_CANLF Olfactomedin like 3 OLFML3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular space [GO:0005615] DTEQQWDTPCPRENAEAAFVIC;GPGIKGKG;PGGPGGGG 3 9.3 1.0036 -1.0577 0 0 0 0 0 0 8.142 0 9.74928 11.912 0 0 0 0 0 A0A8I3PPC8 A0A8I3PPC8_CANLF Transporter SLC6A8 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] symporter activity [GO:0015293] EAWPSLHHH;FMATEQGVHISKVAESGPGLAFI;PLVYNNTY;PYVVLVVLLVRGVLLP 4 8 1.0019 -1.2486 3.56218 8.83393 0 0 0 0 0 0 0 0 0 0 0 0 8.63836 A0A8I3PPD2 A0A8I3PPD2_CANLF [histone H3]-dimethyl-L-lysine(36) demethylase (EC 1.14.11.27) KDM2B Canis lupus familiaris (Dog) (Canis familiaris) embryonic camera-type eye morphogenesis [GO:0048596]; fourth ventricle development [GO:0021592]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of stem cell population maintenance [GO:1902459]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678] nucleoplasm [GO:0005654]; PcG protein complex [GO:0031519] histone H3K36 demethylase activity [GO:0051864]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270] EEKEEEEEEEE;ESCEQQPQEEEK;ETPEAQRDKLY;FSSDSWLEMEEESCE;GVSAKWTHLTEF;IDGFSSDSWLEMEEESCEQ;KKKVKIRRKRRLP;KKKVKIRRKRRLPTKE;KVKIRRKRRLP;LPLDDGAAHVMHR;LPNCWECPKCNHAGKT;LVDVMDVNTQKGTE;PPPDSLPLDDGAAH;PPTDNRPGQMDNRSK;VGTTTRDSLTEINLS;VLPHTAVC 16 11 1.0044 -2.0116 12.2915 10.6621 0 6.34079 0 5.62924 6.61439 0 10.1805 0 0 12.5526 0 11.3431 10.2957 A0A8I3PPD8 A0A8I3PPD8_CANLF Transmembrane protein 120B TMEM120B Canis lupus familiaris (Dog) (Canis familiaris) fat cell differentiation [GO:0045444]; protein heterooligomerization [GO:0051291] nuclear inner membrane [GO:0005637] LSNQAKFAYKDEYE;YLTIILLL 2 6.5 0.98622 -0.45169 0 0 0 0 0 0 0 0 0 0 0 7.97711 0 0 0 A0A8I3PPE0 A0A8I3PPE0_CANLF Cysteine protease (EC 3.4.22.-) ATG4B Canis lupus familiaris (Dog) (Canis familiaris) microautophagy [GO:0016237]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; protein transport [GO:0015031]; proteolysis [GO:0006508] autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] cysteine-type endopeptidase activity [GO:0004197]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]; scaffold protein binding [GO:0097110] LVEQQPSHLACPDVLNLSLDS;RLAPWRPLVLLIPLRLGL 2 9.9 0.93604 0.098105 0 0 0 0 0 4.59837 0 0 0 0 0 0 0 0 8.16043 A0A8I3PPE3 A0A8I3PPE3_CANLF THAP domain-containing protein 1 THAP10 Canis lupus familiaris (Dog) (Canis familiaris) endothelial cell proliferation [GO:0001935] nucleoplasm [GO:0005654] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] RGGAGPPADPAAQPAPPPSP;SVLQKNLRFSQRLRLV;VICSDHFAPA 3 17.9 0.99161 -0.039103 0 0 0 0 0 6.22949 0 0 0 10.9012 0 8.62593 0 0 0 A0A8I3PPE8 A0A8I3PPE8_CANLF Histone deacetylase (EC 3.5.1.98) HDAC7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] histone deacetylase complex [GO:0000118] histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872] CFFNSVAIACRQLQQ;NGTQQTFYQDPSVL;SAPPPPPFSFN;SEPNLKLRYKPKKSLERRKNPLLRK 4 5.9 1.0025 -0.77182 4.40926 8.37994 0 0 0 0 8.94331 9.23838 9.82423 0 0 0 0 0 0 A0A8I3PPF0 A0A8I3PPF0_CANLF Metal cation symporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) SLC39A14 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lateral plasma membrane [GO:0016328]; lysosomal membrane [GO:0005765] metal ion transmembrane transporter activity [GO:0046873] CSSENQENEEDEQI;FTIMLLLTMYSGQIQ;TIMLLLTMYSGQIQ;VGRDNVTHTLH 4 8.2 0.68657 0.29871 0 0 10.1523 12.4589 0 0 0 6.67285 0 0 0 0 0 0 0 A0A8I3PPG0 A0A8I3PPG0_CANLF Cysteine sulfinic acid decarboxylase CSAD Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] LGAFDPLEAIADVCQRHG;LGTDSVRIV;SEQILARCRAV 3 8.2 1.0006 -0.92687 0 6.70888 0 0 0 0 0 0 0 0 8.36868 0 5.32261 0 0 A0A8I3PPG3 A0A8I3PPG3_CANLF Fin bud initiation factor homolog FIBIN Canis lupus familiaris (Dog) (Canis familiaris) protein kinase C signaling [GO:0070528]; response to dexamethasone [GO:0071548]; response to manganese ion [GO:0010042] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] protein homodimerization activity [GO:0042803] LWVGVLWHLCGGYFDGPLYPEMS;YFVPDGDYEENDD 2 17.1 0.98966 -0.22229 0 0 0 0 8.02459 0 0 0 5.67061 0 0 0 0 0 0 A0A8I3PPG7 A0A8I3PPG7_CANLF Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901] EGEFIPESMD;GVHYLHSN;SIIGPTSRDR;SLSTSSGSSIFTPEYD 4 7.1 1.0031 -1.9332 7.93834 0 0 0 0 0 0 0 0 0 0 8.1397 0 13.2375 0 A0A8I3PPG9 A0A8I3PPG9_CANLF RNA helicase (EC 3.6.4.13) DHX40 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723] IEKSCELLFQM;KCALGSKV 2 2.4 1.0037 -1.0689 0 0 12.1107 0 0 4.5114 0 0 0 0 0 0 0 0 0 A0A8I3PPH3 A0A8I3PPH3_CANLF Dystrobrevin binding protein 1 DTNBP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; melanosome membrane [GO:0033162]; nucleus [GO:0005634]; synaptic vesicle membrane [GO:0030672] LLADLESMTANLTN;PRYEDTWAALHRRAKECAS;TQKALEMEH;VPSPVSGPGSGD 4 16.7 1.0032 -1.0572 8.22062 9.30063 6.61444 0 0 0 0 0 0 0 0 0 9.39004 0 0 A0A8I3PPH4 A0A8I3PPH4_CANLF E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) ZNRF1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936] cytosol [GO:0005829]; endosome [GO:0005768]; lysosome [GO:0005764]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GVSTDDSAVPPPGGA;LPCLCIYHKSCIDS;LYTPASRGTGDSERAPG 3 20.3 0.86655 0.16126 0 8.84768 0 8.7239 0 0 0 0 0 7.48374 0 0 0 0 0 A0A8I3PPH7 A0A8I3PPH7_CANLF Adrenomedullin 5 (putative) ADM5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] PWLENKLAQCPA 1 7.9 0.95227 0.05044 8.65374 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PPH8 A0A8I3PPH8_CANLF Uncharacterized protein CCDC78 Canis lupus familiaris (Dog) (Canis familiaris) EWKRVLEQ;LPMERAAATRPGPSPGAAE;LSACQGQL;QHKAPEQGH;WRQRARRRGGPPLGWPQF 5 10.5 1.0029 -1.5253 0 8.86944 0 0 0 10.8694 10.6629 0 0 0 0 0 0 0 0 A0A8I3PPI6 A0A8I3PPI6_CANLF Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) DMRTA2 Canis lupus familiaris (Dog) (Canis familiaris) cerebral cortex regionalization [GO:0021796]; dopaminergic neuron differentiation [GO:0071542]; neuroblast proliferation [GO:0007405]; neuron fate specification [GO:0048665]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of DNA-templated transcription [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]; stem cell fate specification [GO:0048866] nucleus [GO:0005634] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] SSPEVRPGSGSENGDGESFSGSP 1 4.3 0.97834 0.046253 0 0 0 0 5.03281 0 0 0 0 0 5.36328 0 0 0 0 A0A8I3PPI8 A0A8I3PPI8_CANLF Olfactory receptor OR7G13 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLFSLFLSIYLATIL 1 4.8 0.95441 0.053874 0 0 0 0 0 0 0 0 10.1511 0 0 0 0 0 0 A0A8I3PPK9 A0A8I3PPK9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GSTPWRPRLVGSAP;LVGSWRPRLVGSA 2 16.7 0.98949 -0.5298 0 0 0 0 0 0 12.4615 0 12.6356 0 0 0 0 0 0 A0A8I3PPL4 A0A8I3PPL4_CANLF Zinc finger protein 605 ZNF605 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGMAYCGCS;KSQISFEDVAVDFTL;PNANHITHTGVHLC;SLKMWHQDNQDKLRSM;TGEKNYQCN 5 9.8 1.0034 -1.5515 0 4.96611 0 8.73836 0 0 0 4.48414 10.0254 0 0 0 5.2639 0 7.46361 A0A8I3PPL7 A0A8I3PPL7_CANLF "Membrane associated guanylate kinase, WW and PDZ domain containing 2" MAGI2 Canis lupus familiaris (Dog) (Canis familiaris) DIVKLIKDAGLSVTLRI;EVVDILKDCPIGSETSLIIHRG;PEDGPPPLAPSHP;QKGSVDHELQQIIRDNLYLRTVP;SQPYPAPVYSQPEELKEQMDDA;VGDQIIEINGESTR;YRQPPLLDYRQHSPDTRQYPLAD 7 9.5 0.9784 0.046253 0 0 0 0 0 0 0 0 0 0 7.36597 0 0 0 0 A0A8I3PPM0 A0A8I3PPM0_CANLF Serine/threonine kinase 32C STK32C Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DDALPVAHSP;ESRPLHKKKKR;FELEEMIL;IEHVFLVNLW;LDEQGHAHL;SRPLHKKKKRLAKN;VGVLAYELL;VLWQDLSE 8 13.6 1.0029 -2.5684 11.825 0 7.80142 0 0 0 0 0 0 0 0 9.15439 12.3787 0 0 A0A8I3PPN5 A0A8I3PPN5_CANLF Olfactory receptor OR13A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLADAFYGI 1 2.7 0.98971 0.026168 13.2617 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PPN6 A0A8I3PPN6_CANLF DnaJ heat shock protein family (Hsp40) member B14 DNAJB14 Canis lupus familiaris (Dog) (Canis familiaris) GGNEGGKGYTKDQIDGVLRGL 1 19.3 0.98511 -0.23705 4.91136 0 0 0 0 0 0 0 0 0 0 0 5.72844 10.4392 0 A0A8I3PPP0 A0A8I3PPP0_CANLF Major facilitator superfamily domain containing 6 MFSD6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AWGVSSSPWVTFVYALYQIKE;DLVQQQTED;EPPSNATPTSTETAAIPEEEIDW;LLVGIRYFIEF;LVQQQTEDV;VQQQTEDVLP;VSELTAYFFSHK 7 10.7 1.0017 -0.9119 8.91815 9.26812 15.0604 0 0 0 13.9532 0 0 0 9.36547 0 0 9.98271 0 A0A8I3PPR0 A0A8I3PPR0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TTSNYTSWYQQTQGQSPRML 1 14.1 0.96156 0.048782 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1625 0 A0A8I3PPR3 A0A8I3PPR3_CANLF Kinase non-catalytic C-lobe domain containing 1 KNDC1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AAQALLPRGPV;AELQSCSPGWCSAFYEADCFG;DQRRPQVE;EDPRDRPDLESI;ELPGPGCH;EPATDTAQGSPCP;GLDAPCPAQPPRSKATE;MARRSAQERPCPAE;NFEVGFRPQ;PDRVQHPAALQ;PLGLMAYLYSSDAFLEGYVQQFLYT;PPPSLSDV;RPLQRGRRL;SPLPRTACPSLQ;VGFRPQKS 15 9.3 1.0027 -2.1215 0 9.07738 0 8.84304 0 7.07767 0 0 0 0 0 0 10.5289 0 10.4022 A0A8I3PPR6 A0A8I3PPR6_CANLF LEM domain containing 1 LEMD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NIILSSEKNKALKKNPVFEI 1 9.5 0.94777 0.054659 0 0 0 0 0 0 0 10.7377 0 0 0 0 0 0 0 A0A8I3PPR7 A0A8I3PPR7_CANLF Sodium channel modifier 1 SCNM1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] enzyme binding [GO:0019899]; metal ion binding [GO:0046872] ELRQSEIKAEAP 1 5.2 0.95235 0.05044 0 0 0 0 0 0 9.94033 0 0 0 0 0 0 0 0 A0A8I3PPR8 A0A8I3PPR8_CANLF RRM domain-containing protein LOC119866711 RBMX Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]" spliceosomal complex [GO:0005681] RNA binding [GO:0003723] GGSYRDSYESYGNS;LYSSGRDRVG;SGMGGRAP 3 8.2 0.98708 -0.50258 0 0 9.80348 0 7.36072 0 0 0 0 0 0 0 0 0 0 A0A8I3PPS2 A0A8I3PPS2_CANLF Uncharacterized protein LOC100686146 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] GEDEEDPDEGDDDS;GVTEFCRQT;HIESSLLSMSSLPTEK;INGKYCCPKIYFN;ITAVRGSYLWLQLEVH;SEQQDELQEESEM;VHKKKRSSASVDNTP 7 20.5 1.0031 -1.1136 0 0 8.45323 0 0 0 0 0 9.61174 10.0207 5.0347 0 0 6.33222 10.2104 A0A8I3PPT6 A0A8I3PPT6_CANLF DUF4587 domain-containing protein PRR29 Canis lupus familiaris (Dog) (Canis familiaris) AGDAGGSQ;PRVTVLQPVAW 2 7.3 1.0046 -1.1044 8.68811 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PPU2 A0A8I3PPU2_CANLF Sorting nexin 27 SNX27 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] early endosome [GO:0005769]; membrane [GO:0016020] phosphatidylinositol-3-phosphate binding [GO:0032266] GGGGGGGG;GGGGGGSG;GGGGSGLHC;SITHFKLHACTEEGQLENQVI;VEGATHKQVVDLI 5 9.1 1.0022 -0.90664 12.6233 0 0 0 0 0 0 0 0 0 0 9.49869 10.8169 0 0 A0A8I3PPU7 A0A8I3PPU7_CANLF Olfactory receptor family 52 subfamily AC member 1 OR52AC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIEPTLHSPMYL;VGRLGLLALAKGVILILPMP;VILILPMPLLLRRL 3 12.8 0.85567 0.1893 0 0 0 0 4.22936 0 0 0 0 9.57822 9.93851 0 0 9.92853 6.74335 A0A8I3PPV0 A0A8I3PPV0_CANLF Zinc finger protein 358 ZNF358 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ATAHIYHVN;QSSNLQHHLRIHTG;SEDLDPDADPDAE;SPEWVQEQGALLGPD 4 5.7 1.0026 -0.77796 9.64128 0 0 5.22153 0 0 0 0 0 0 9.1581 0 0 8.80793 0 A0A8I3PPW2 A0A8I3PPW2_CANLF Tuberoinfundibular peptide of 39 residues (Parathyroid hormone 2) PTH2 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] LLLLLLLL;LLLLLLLLL;LLLLLLLLLV;LLLLLLLLLVPW;RLLLLLLL;RLLLLLLLL;RMRLLLLLLLLLV 7 15.2 0.91723 0.11 0 0 0 0 0 3.74211 0 0 0 0 4.21622 0 0 0 0 A0A8I3PPW3 A0A8I3PPW3_CANLF Arp2/3 complex 34 kDa subunit ARPC2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament polymerization [GO:0030041]; Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737] actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200] TNASARDNTINLIHTFRDYLHYHI 1 8 0.99277 -0.2909 0 0 0 0 0 8.86412 0 0 0 0 0 0 0 0 0 A0A8I3PPW7 A0A8I3PPW7_CANLF Lysosomal associated membrane protein 1 LAMP1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; lysosomal lumen acidification [GO:0007042]; positive regulation of natural killer cell degranulation [GO:0043323]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513] autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; cytolytic granule membrane [GO:0101004]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; melanosome [GO:0042470]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagolysosome membrane [GO:0061474]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021] enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein domain specific binding [GO:0019904] AAFGGARPRPLLLLLLAGL;RPLLLLLLA 2 4.6 0.98929 -0.22254 0 0 0 4.13002 0 0 0 0 0 0 0 0 0 9.59208 0 A0A8I3PPX7 A0A8I3PPX7_CANLF Uncharacterized protein DNAJB3 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082] EAIKKAYRKLALRWHPD;GGSGPCHD 2 10.5 0.98996 -0.21969 0 0 0 0 0 0 11.4287 0 11.6747 0 0 0 0 0 4.6597 A0A8I3PPY2 A0A8I3PPY2_CANLF A-kinase anchoring protein 17A AKAP17A Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] cytosol [GO:0005829]; nuclear speck [GO:0016607] nucleic acid binding [GO:0003676]; protein kinase A binding [GO:0051018] EERQRAEERKQKELEE;IPMLDPYREEMTGRNF;SPLRRSASPDH;VHNHQFSTLRISKSTMDFIRFEGE 4 9.4 0.86312 0.17526 0 7.52521 0 7.8885 0 0 0 7.75962 0 0 11.8504 0 0 0 0 A0A8I3PPY4 A0A8I3PPY4_CANLF ADAM metallopeptidase domain 17 ADAM17 Canis lupus familiaris (Dog) (Canis familiaris) "cell adhesion mediated by integrin [GO:0033627]; cellular response to high density lipoprotein particle stimulus [GO:0071403]; commissural neuron axon guidance [GO:0071679]; defense response to Gram-positive bacterium [GO:0050830]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; Notch receptor processing [GO:0007220]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of chemokine production [GO:0032722]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein processing [GO:0016485]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; wound healing, spreading of epidermal cells [GO:0035313]" actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; ruffle membrane [GO:0032587] integrin binding [GO:0005178]; interleukin-6 receptor binding [GO:0005138]; metal ion binding [GO:0046872]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; Notch binding [GO:0005112]; PDZ domain binding [GO:0030165]; tumor necrosis factor binding [GO:0043120] DEGEECDPGIMYLNNDTCCSSDCML;DLQASTHIE;DLVTTHELGH;FFSGHVVGEPDS;FQQKILYFLGVNNHLTFISENL;HLESCACNETDNSC;VHCVDKKLDKQYESL;VTTHELGHNFGAEHDPD 8 14.1 0.97431 0.048094 0 0 0 0 0 0 0 0 0 0 0 0 0 9.61616 0 A0A8I3PPZ1 A0A8I3PPZ1_CANLF "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial" NFU1 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]" EDGGDVIYKGFED;EELDWNLLKPDIYAT;RAPRLWDLY;TIKKQPLHQFVQRPL 4 19.7 1.0019 -1.2729 0 0 8.68306 0 0 0 0 0 0 9.55631 0 0 0 0 0 A0A8I3PQ09 A0A8I3PQ09_CANLF "PMS1 homolog 1, mismatch repair system component" PMS1 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] mismatch repair complex [GO:0032300]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] GEAVRLSRQLPMYLSKE;HKLPAQPLEKPIILTESL;KPTSAWNLAQKHKLK;KSGKNTNY;SEIKECVHGRPFF;TASDNFSTQYVLDG 6 10.1 1.0028 -1.4922 0 0 0 0 13.2311 0 0 0 9.60666 0 0 0 9.26945 10.4463 0 A0A8I3PQ16 A0A8I3PQ16_CANLF "5',3'-nucleotidase, mitochondrial" NT5M Canis lupus familiaris (Dog) (Canis familiaris) dUMP catabolic process [GO:0046079] 5'-nucleotidase activity [GO:0008253] VLGLLQPSAEPLPY;YWGDKVILSIQAQKGCCWESRE 2 12.9 0.92108 0.11244 6.01165 0 7.86876 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQ21 A0A8I3PQ21_CANLF Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (Phosphotyrosyl phosphatase activator) PTPA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase activator activity [GO:0019211] IDEIPPVDQPSRF;QAIEKLVALLNTLDRWIDEI;SSQLIDHPFLEPRHF 3 15 0.98842 -0.34319 0 0 7.15826 0 0 10.1037 10.2909 0 0 0 0 0 0 0 0 A0A8I3PQ22 A0A8I3PQ22_CANLF Uncharacterized protein CST8 Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type endopeptidase inhibitor activity [GO:0004869] CLWFAMQEY;VGALPWNGEF 2 13.4 1.0019 -0.90704 0 0 8.76065 0 0 0 0 0 0 0 0 0 0 0 9.2159 A0A8I3PQ24 A0A8I3PQ24_CANLF "Protein preY, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) VSFCAFMC 1 7.5 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 4.39979 0 8.02923 0 0 A0A8I3PQ38 A0A8I3PQ38_CANLF Adenine nucleotide translocase lysine methyltransferase ANTKMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] mitochondrial membrane [GO:0031966] protein-lysine N-methyltransferase activity [GO:0016279] GQSPLGQAEGWGAGEGVG;GVGALSSGCWSCWGGH;VLGEGLDRVWAYDV;WVWALYFLGLKVEMERGPSPL 4 10.5 0.99409 -0.025611 9.59636 9.67643 9.49446 0 9.92782 0 10.624 6.93263 0 0 11.101 7.48083 0 8.02253 0 A0A8I3PQ39 A0A8I3PQ39_CANLF Keratin 75 KRT75 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424] extracellular space [GO:0005615]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] EFVVLKKD;EIDNLKKQC;EVKAQYEDIANRS;GRLSSAGAAFGSRSLYN;GVGPVNISVVSSSGGTGYS 5 11.3 0.97687 0.046227 0 0 0 0 0 8.32504 0 0 0 0 0 0 0 0 0 A0A8I3PQ43 A0A8I3PQ43_CANLF TNF receptor superfamily member 25 TNFRSF25 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] plasma membrane [GO:0005886] AGSPFRCHPCSDCRALHRHTRVP;EAEIEAVEVEVGRFRDQQYEMLKRW;PAGHYLKGPCL;VGRFRDQQ;VMDAVPARRWKEF 5 17.3 1.0026 -1.1819 0 0 9.32674 5.93546 0 0 5.84664 0 9.94892 0 0 0 0 0 0 A0A8I3PQ47 A0A8I3PQ47_CANLF TIAM Rac1 associated GEF 1 TIAM1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EICPKVTQNIQIEKS;KMQHYVPKPEEDIYELLYKEIEICP;LDQIFVWEQ;LFALTDAESEEHYHL;LSRCLFSSMAIEW;LSTCQRANSLGDL;QMDLFRYRCYLASLQ 7 6.4 1.0024 -0.76246 0 4.71798 0 0 0 0 0 0 0 0 8.94734 0 10.4353 11.5801 0 A0A8I3PQ56 A0A8I3PQ56_CANLF Multidrug resistance-associated protein 1-like ABCC13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ISTIGLHDLRGK;LLRKTKILILDEATASIDFK;LVATRVKKLKILKL;NMNKEAPWIM;PIFEKQWRKEV;VATRVKKLKILKL;VIPVNALVATRVKKLKILKL;YYVASSRQIRRLAGASRSPI 8 7.3 0.98898 -0.302 9.34946 0 0 3.83956 0 0 8.33945 0 8.17861 0 0 6.83845 4.61324 4.95713 0 A0A8I3PQ59 A0A8I3PQ59_CANLF Nuclear receptor subfamily 2 group C member 1 NR2C1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of retinoic acid receptor signaling pathway [GO:0048386] PML body [GO:0016605] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" FGMRQDSVQCERKP;LLTDNSSPD 2 3.8 1.0037 -1.0603 0 0 0 0 0 0 0 0 0 0 0 0 7.79383 9.47923 0 A0A8I3PQ62 A0A8I3PQ62_CANLF Ankyrin repeat and SOCS box containing 12 ASB12 Canis lupus familiaris (Dog) (Canis familiaris) LDVKAQTPLFTAVSHGHLDCV;LLAHGADV 2 9.3 0.96483 0.048716 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.96023 A0A8I3PQ69 A0A8I3PQ69_CANLF Olfactomedin 2 OLFM2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of smooth muscle cell differentiation [GO:0051152]; protein secretion [GO:0009306]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; synapse [GO:0045202] QSMEVLELRTYRDLQ;VLSTMAMVTNWMS;VPLLKIGAVLSTMA 3 7.5 0.98754 -0.3238 0 0 0 0 11.4076 9.70188 0 0 0 0 0 0 0 0 0 A0A8I3PQ82 A0A8I3PQ82_CANLF Uncharacterized protein LOC111092404 Canis lupus familiaris (Dog) (Canis familiaris) ELERMKCPL 1 3.8 1.0035 -0.80421 0 0 0 0 0 0 0 8.58124 0 0 0 0 0 0 0 A0A8I3PQA0 A0A8I3PQA0_CANLF Prolyl endopeptidase (EC 3.4.21.-) PREPL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794] serine-type endopeptidase activity [GO:0004252] DEEADNDNYE;HVIEDSHKKITAQ;LADLEACIKTL;LEAPFLDVLNTMM 4 7.4 1.0047 -1.0515 0 6.26082 0 0 5.18492 6.28251 0 0 0 0 0 0 9.69399 9.6453 0 A0A8I3PQA2 A0A8I3PQA2_CANLF Bromodomain PHD finger transcription factor BPTF Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] NURF complex [GO:0016589] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AEETQDSEDDEEDEMEEDDDDSD;CCETCSAVYHLE;CDYQDGLDTLPSTKES;DAEETQDSEDDEEDEMEEDDDD;DDEEDEMEEDDDD;DDEEDEMEEDDDDSD;DEEDEMEEDDDD;DEEDEMEEDDDDS;DEEDEMEEDDDDSDY;DEEDEMEEDDDDSDYPEEMEDDDD;DIDIVKSPEEIEKDKNETE;DSDYPEEMEDDDDD;DSEDDEEDEMEEDDDDSDYP;DSEDDEEDEMEEDDDDSDYPE;DVYICNDC;EDDDDDASYCTE;EDDDDSDY;EDDDDSDYPEEMEDDDDD;EDDEEDEMEEDD;EDDEEDEMEEDDD;EDDEEDEMEEDDDDSDYPEE;EDEMEEDDDDSD;EDEMEEDDDDSDYPEEMEDDD;EEDDDDSDYPEEMEDD;EEDDDDSDYPEEMEDDDDDASY;EEEEEEEDMVSEEEEEEEEED;EEEEEEEDMVSEEEEEEEEEDGDA;EMEDDDDDASYCTE;ETQDSEDDEEDEMEED;GGRGGGGG;GPADLKDSVNSTLYF;GPVIIETWVAEEEL;IDGMTWPEV;IREVPYFNYNAKPA;NENRESEKK;PNTSGSGG;PQSPAQPEVQT;RTETSETEITTTEII;SEDDEEDEME;SEDDEEDEMEEDDDD;SKLSQLKSQ;SLPSVPKST;TQDSEDDEEDEMEE;TQDSEDDEEDEMEEDDDD 44 7.7 0.99755 -3.536 11.2396 10.107 8.39506 8.56159 10.0253 3.40409 6.23536 9.25106 9.47176 4.55072 10.807 10.1604 11.1867 10.6747 10.6016 A0A8I3PQB2 A0A8I3PQB2_CANLF SEC7 domain-containing protein IQSEC3 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] GAQVDPQLKQGSPTAK;GVLTRRPENETVL;LHQFCCPAADAE;PEQPPLQH;PGAARAENTCAEAGARGSPRAH;SLPPTLAGTLTELE;SSSSDSCGST;VGLLGMQFHLFENEYYSHGITLVTP;YSPNIKPDRKMMLE 9 11.1 1.0014 -0.9377 0 10.4229 0 12.5637 0 8.01044 11.0973 0 11.1296 0 0 0 0 0 13.8273 A0A8I3PQC1 A0A8I3PQC1_CANLF Calponin-homology (CH) domain-containing protein CFAP47 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] DIQILLKNP;EHITINCQVGNIT;ENSPESDCHSPN;ESSTFLSLPSQ;FGDVCVNS;FKASELYTQYCSSNSPM;HRLCKESMKDALIAFPND;IMLVATEPDVDDV;LEPEDYKKWIEITEKHY;LGVTFPKGIVI;VGEELGTNIHQKT;VGLYNHQNYFAKFEWQPV;VNPCFSSSNIYSN;VPNYTKTIQ 14 5.9 0.99893 -2.9307 0 6.6476 0 10.427 9.6325 8.19131 8.7951 0 8.99271 9.22863 0 9.05891 8.32481 0 0 A0A8I3PQC9 A0A8I3PQC9_CANLF 5-hydroxytryptamine receptor 3C LOC478649 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888] ATGTPLIS;IYTVENMVLGMEKKVQEISDTSRNL 2 7.5 0.9898 -0.21213 0 0 0 0 0 9.83813 10.3822 0 0 11.3883 11.2659 11.198 0 0 0 A0A8I3PQE3 A0A8I3PQE3_CANLF Cyclic nucleotide-gated channel alpha-2 (Olfactory cyclic nucleotide-gated channel subunit 1) CNGA2 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of smell [GO:0007608] ciliary membrane [GO:0060170] monoatomic ion channel activity [GO:0005216] FVIAMPVLYNWCL;GYSDLFCL;IDAVKHYMQFRK;ITDPEYGYLAREYIYCLY;SSRPQSAADDDTSSEL;YILVIIHWNACIYYAISKSIGFGV 6 13.7 0.98785 -0.46568 0 0 0 0 10.9816 7.52959 10.8032 8.07959 0 0 0 0 13.1412 0 0 A0A8I3PQE7 A0A8I3PQE7_CANLF Zinc finger protein 711 ZNF711 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DDDDDDDDDVKSTSEDYL;DISCAEIADEVYM;EDDDDDDD;EDDDDDDDDDDD;ICDTINTNKVLKQ;PQAFGDERELQRHLDLFQGHKTHQ;TEDDDDDDDDDDD;VTNSDTETVIQAAG 8 10.6 0.98957 -0.22372 0 0 10.1326 0 0 0 0 0 11.3406 0 0 0 8.4845 8.5012 12.3307 A0A8I3PQF2 A0A8I3PQF2_CANLF Helicase like transcription factor HLTF Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767] nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575] "ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]" ELRKKLIRKMKLILS;KLFEDLKEDDKTHEME;NEGTVLAHYADVL;QEVIITKFIVKDSVE;TDTEDRPRTTLIICP 5 7.3 1.0004 -0.61821 8.54794 0 0 0 0 0 0 12.08 0 0 5.91179 0 0 0 4.50437 A0A8I3PQF9 A0A8I3PQF9_CANLF Uncharacterized protein LOC102156375 Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type endopeptidase inhibitor activity [GO:0004869] KFTMIYLMELELGQT 1 10.7 0.9518 0.053888 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.53084 A0A8I3PQG4 A0A8I3PQG4_CANLF RNA polymerase II-associated protein 3 RPAP3 Canis lupus familiaris (Dog) (Canis familiaris) ESDFRQLKNSPD;FMRDLENWEKDIKQKDMELRRQNGV;KIKKKPLKKVII;KIKKKPLKKVIIEETGN;LSKIKKKPLKKV;VLELEPNNFEATNEL;VLKVEEISDTSTQPP 7 13.7 0.93852 0.075291 0 6.69098 0 0 11.0769 11.3374 0 0 0 3.72312 0 0 0 9.22603 4.70332 A0A8I3PQG5 A0A8I3PQG5_CANLF Family with sequence similarity 53 member B FAM53B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein import into nucleus [GO:0006606] nucleus [GO:0005634] MEDCGPHSPFALHVSS 1 3.8 0.98742 -0.22956 0 0 0 0 12.2609 0 0 0 0 0 0 0 0 0 0 A0A8I3PQH2 A0A8I3PQH2_CANLF "phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)" PIK3CG Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737] kinase activity [GO:0016301] CQRRTSPKLFTEEV;DPTALSNETIGIIF;ELIPIEFVLPT;ETSAAADFYQRLGP;LVDDCTGVTGYHEQLTIH;QAAVERFVYSC;TESLDLYLLPYGCI;VGNTGAFKDEVL 8 10 1.0024 -1.1327 0 8.73498 0 9.39296 0 10.8369 0 10.0812 0 0 9.54986 5.10614 0 0 4.47457 A0A8I3PQH4 A0A8I3PQH4_CANLF ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) MMGT1 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; EMC complex [GO:0072546]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] inorganic cation transmembrane transporter activity [GO:0022890] SNQDALSSNTSLKLRKLESL;VTCYGIVHIAGE 2 8.2 0.99395 -0.13159 0 0 0 5.50868 0 0 0 12.1729 0 0 0 0 0 0 0 A0A8I3PQH6 A0A8I3PQH6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) APPVLTQPPSA;APPVLTQPPSASA;APPVLTQPPSASASL;APPVLTQPPSASASLEA;EADYYCFTPDDSN 5 16.8 0 11.221 10.9218 11.685 11.5122 9.05591 0 10.0251 10.038 9.72758 0 10.7234 10.5961 8.50938 11.9405 11.6502 11.849 A0A8I3PQH7 A0A8I3PQH7_CANLF Hypoxia inducible lipid droplet associated HILPDA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of lipid storage [GO:0010884] membrane [GO:0016020] GGILESSWTTRG 1 18.2 0.99371 -0.12424 0 10.5546 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQH9 A0A8I3PQH9_CANLF Nucleophosmin Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of centrosome duplication [GO:0010824]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit biogenesis [GO:0042274]; ribosomal small subunit export from nucleus [GO:0000056] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] chromatin binding [GO:0003682]; histone binding [GO:0042393]; RNA binding [GO:0003723] AADEDDDEDDDDD;AADEDDDEDDDDDDDED;AADEDDDEDDDDDDDEDDDNF;DDDDEDDDNFDDE;DDDEDDDDDDDE;DDEDDDDD;DEDDDDDD;DEDDDDDDDEDDDNFDDE;DEDDDEDDDDDDDEDDD;EDDDDDDD;EDDDDDDDEDDDNFDDEEA;EDDDDDDDEDDDNFDDEEAKE;EDDDEDDDDDDDEDDDNFD;LAADEDDDEDDDDDDDE;VEEDAESEDEEEDV 15 24.9 0.74148 0.24377 0 7.66121 4.6522 6.20314 6.94883 7.0387 7.64053 6.71039 6.42487 0 6.56675 5.10606 12.6769 8.04521 0 A0A8I3PQI2 A0A8I3PQI2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CTGSWAQSVLTQPASVSGS;DEADYYCSSWDRS;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 8 24.8 0.94955 0.059561 0 0 0 0 0 0 0 6.54085 0 0 0 0 0 0 0 A0A8I3PQJ0 A0A8I3PQJ0_CANLF 4-hydroxyphenylpyruvate dioxygenase HPDL Canis lupus familiaris (Dog) (Canis familiaris) aromatic amino acid metabolic process [GO:0009072] mitochondrion [GO:0005739] 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; metal ion binding [GO:0046872] AARALVARGCSVPVP 1 3.8 0.98399 -0.24758 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.64171 A0A8I3PQJ1 A0A8I3PQJ1_CANLF Inactive ADP-ribosyltransferase ARH2 (ADP-ribosylhydrolase-like protein 1) ([Protein ADP-ribosylarginine] hydrolase-like protein 1) ADPRHL1 Canis lupus familiaris (Dog) (Canis familiaris) sarcomere [GO:0030017] ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287] ERLETLVEVSIECGRMTHNHPTGFL 1 7.1 0.98762 -0.23426 0 0 11.0074 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQJ3 A0A8I3PQJ3_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DMQDAWPEI;VSSPPYLLGADL 2 8.7 0.99316 -0.17407 0 0 0 8.35434 13.6081 0 0 0 0 0 0 0 0 0 0 A0A8I3PQJ7 A0A8I3PQJ7_CANLF "Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5)" OPA1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; mitochondrial fusion [GO:0008053] microtubule [GO:0005874]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; lipid binding [GO:0008289]; microtubule binding [GO:0008017] AHQVTTRNLSLAVSD;DTWHQVYRRHFLKTALNHCNLC;IDQLQEELLHTQ 3 5.3 0.86398 0.17686 0 0 0 0 7.98897 0 0 10.0024 0 0 0 0 0 0 0 A0A8I3PQJ9 A0A8I3PQJ9_CANLF "Protein kinase domain containing, cytoplasmic" PKDCC Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501] extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] HGGCLLSVFNLAEA;LGSVTLLDFRPRQFVLVD;RNLYNAYRFFF 3 8.6 0.99201 -0.18295 2.55351 0 0 0 0 0 0 5.11977 0 0 0 0 0 8.29057 0 A0A8I3PQK3 A0A8I3PQK3_CANLF Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC 3.6.1.1) LHPP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] phosphatase activity [GO:0016791] DGGSPIPGSVEA;GGEDGGSPIPGS;LDISGVLY 3 10.9 1.003 -0.85023 0 0 0 0 0 0 0 0 9.53064 0 0 0 0 0 0 A0A8I3PQK9 A0A8I3PQK9_CANLF Macrophage stimulating 1 MST1 Canis lupus familiaris (Dog) (Canis familiaris) embryo implantation [GO:0007566]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of epithelial cell apoptotic process [GO:1904036]; positive regulation of gene expression [GO:0010628]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; proteolysis [GO:0006508]; regulation of macrophage chemotaxis [GO:0010758]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425] vacuole [GO:0005773] receptor tyrosine kinase binding [GO:0030971]; serine-type endopeptidase activity [GO:0004252] FTAISAPDAH;RWDAQKPHQHRF;VISNQECNIKHRGRIRENEM 3 5.8 0.99803 -0.60635 0 0 0 0 0 12.6032 11.7725 0 0 0 0 0 0 0 0 A0A8I3PQL4 A0A8I3PQL4_CANLF Metalloendopeptidase (EC 3.4.24.-) BMP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cartilage development [GO:0061036]; proteolysis [GO:0006508] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] FMEMDIESQPECA;GVARLPLPLLLWLLLLPRPGRPLD;HMHCVWRISVTPGEKI;ITKKGFHLRYTSTKFQ;PDDYRPSKVCIWRIQ;SIKTAAPGNSSAFNCQS;SSPEYPNGYSAHMHCVWRIS 7 11.3 0.62174 0.34823 0 0 6.91767 7.34012 6.57812 0 8.55236 0 0 0 0 6.31038 0 0 9.39365 A0A8I3PQL5 A0A8I3PQL5_CANLF Crystallin zeta like 1 CRYZL1 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] EDPGLCEVVRVHEH 1 4.2 0.93307 0.060832 0 8.78516 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQL9 A0A8I3PQL9_CANLF CASK interacting protein 2 CASKIN2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EAPVPAGL;KPGHRKKI;SPPPGQGP;VHYRSGEQLFTQD 4 3.1 1.003 -2.4605 0 0 0 0 0 0 10.0382 0 0 0 0 0 10.1542 0 9.57331 A0A8I3PQN0 A0A8I3PQN0_CANLF Cystatin like 1 CSTL1 Canis lupus familiaris (Dog) (Canis familiaris) signaling receptor ligand precursor processing [GO:0140448] cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type peptidase activity [GO:0008234] SQMQLTTGVEYMVT 1 10.1 0.98971 -0.21988 0 0 0 0 0 0 0 0 9.98028 0 0 0 0 0 0 A0A8I3PQN4 A0A8I3PQN4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EKLLKCPYDKK;EYTWQCPPCDKDWDKDLWEQTS 2 18.3 0.94555 0.082333 0 0 0 0 0 5.34184 0 0 0 10.6705 0 0 0 0 0 A0A8I3PQN6 WWTR1_CANLF WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) WWTR1 TAZ Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; SMAD protein signal transduction [GO:0060395]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894] cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; tight junction [GO:0070160]; transcription regulator complex [GO:0005667] protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] KILPESFFKEP;VPTTPEDFLS 2 5.2 1.0015 -0.91294 0 0 4.34575 3.39012 0 0 9.2542 0 0 0 0 0 0 0 0 A0A8I3PQN7 A0A8I3PQN7_CANLF Translocon-associated protein subunit delta (Signal sequence receptor subunit delta) SSR4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] SVDHRGTWNG;TVSVDHRGTW 2 8.1 1.0023 -1.2229 0 0 0 0 0 0 0 0 0 9.26875 0 0 10.3056 0 0 A0A8I3PQN9 A0A8I3PQN9_CANLF Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) MAP4K3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349] FIGTPYWMAPE;GVSRGRDFNQVVR;LDKVNNPDHSTYHDFDDDD 3 5.2 0.91459 0.10926 0 0 0 0 0 0 0 0 9.82083 0 0 0 0 0 0 A0A8I3PQP7 A0A8I3PQP7_CANLF Peptidase S1 domain-containing protein LOC478844 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] PDVQINQTV;VLCQNQLQ 2 6.5 1.0016 -1.3138 0 0 0 0 0 0 0 0 0 0 10.8375 0 0 0 0 A0A8I3PQQ7 A0A8I3PQQ7_CANLF UDP-N-acetylglucosamine pyrophosphorylase 1 UAP1 Canis lupus familiaris (Dog) (Canis familiaris) uridylyltransferase activity [GO:0070569] AELGSSGR;EKYHGNKCVI;GAARSGRVCGSGAALGAGAGEGGG;QDQLQAWESEGL;RTMESTKEFFTKHKYFG 5 10.2 0.97405 0.041303 0 0 0 0 0 9.06045 0 0 0 0 0 0 0 0 0 A0A8I3PQQ8 A0A8I3PQQ8_CANLF Uncharacterized protein LAS1L Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] Las1 complex [GO:0090730] endonuclease activity [GO:0004519] DEDEDEDEEEEEDRME;DLEDQVEEEEEENDD;DQVEEEEEENDDQKWEEEDEDDEDE;EDEDEEEE;EDQVEEEEEENDDQKWEEEDED;EEEEENDDQ;EEEEENDDQKWEEED;EEEEENDDQKWEEEDE;EEQFKVLEKFRRLPQAIK;EEQGSLNDLKKDEKDE;KDEKDLEDQVEEEEEENDDQKWEEE;NDDQKWEEEDEDDEDEDEDEEEEED;QFWQPLLRGLHS;SEDVRWNTFPLGLMP;TEVQRGEGTDPKL;VLDWLQKTYWCRQ;WEEEDEDDEDEDEDE;WEEEDEDDEDEDEDEEEE 18 17.3 1.0033 -0.89159 10.4189 9.04215 0 0 8.55612 7.70155 9.89339 10.4529 6.34024 9.27417 0 0 7.89664 6.79468 8.84521 A0A8I3PQR1 A0A8I3PQR1_CANLF Synaptic vesicle 2-related protein SVOP Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] FRRTGESARSEDDTASGE;LWIIDRLGRKKTM;SVLTGLAWMA 3 7.5 0.94239 0.059626 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.97528 A0A8I3PQR2 A0A8I3PQR2_CANLF Testis expressed 51 TEX51 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AELSQNQDHMEE;ATAKLFNHIDET 2 14.2 0.957 0.05044 0 7.88001 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQR3 A0A8I3PQR3_CANLF Tripartite motif containing 33 TRIM33 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] DNLQHSKK;EDSDEDFIQPRRKRL;GAAGPDDGG;HNTTINPTSPTTAT;SESVGASGQRPV;SGAAGPDDGGV;SSKDDDPNEDWCAV;VGFCVECGEWLCKT 8 7.9 1.0027 -1.5848 0 3.95949 0 0 7.87646 10.124 0 0 9.80768 9.08709 0 0 0 0 0 A0A8I3PQR5 A0A8I3PQR5_CANLF Surfactant protein C (Pulmonary surfactant-associated protein C) SFTPC Canis lupus familiaris (Dog) (Canis familiaris) respiratory gaseous exchange by respiratory system [GO:0007585] extracellular region [GO:0005576] FPSSLKRLLIIVVVIVLVVVVIV;GRLGIPCFPSSLKRLLIIVVVIVLV;KRLLIIVVVIVLVVVVI;KRLLIIVVVIVLVVVVIVGA;LKRLLIIVVVIVLVV;LKRLLIIVVVIVLVVVV;SLKRLLIIVVVIVLVVV;SLKRLLIIVVVIVLVVVVIV;SLKRLLIIVVVIVLVVVVIVG;SLKRLLIIVVVIVLVVVVIVGAL;SSLKRLLIIVVVIVLVVVVIVGALL;VGALLMGLHM 12 24.2 0.9898 -0.31095 7.0227 8.87446 6.46308 0 3.6011 4.19417 0 4.81537 0 9.78106 5.05329 0 0 8.5004 0 A0A8I3PQS1 A0A8I3PQS1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] aldose reductase (NADPH) activity [GO:0004032] VGLAIQKKLK 1 10.5 0.99884 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 4.30546 0 A0A8I3PQS4 A0A8I3PQS4_CANLF oxoglutarate dehydrogenase (succinyl-transferring) (EC 1.2.4.2) PARG Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [GO:0016624]; thiamine pyrophosphate binding [GO:0030976]" ALVLWEAQFGDF;GAELVWCQEEH;HVLRRQVLLPFRKPLIIFTPKSLLR;LEQIFCQFDPKLEAA;LVEDHLAVQ;PGVMQFSSEEKRTL;RRQVLLPFRK;VVVDLVCYRRRGH 8 10.8 0.98753 -0.35399 10.0705 8.33042 0 5.4225 0 0 8.39292 0 7.35209 0 6.4019 0 0 0 0 A0A8I3PQT0 A0A8I3PQT0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane translocase complex [GO:0005742] NVILSLGLAAAGLW 1 13 0.98608 -0.25837 0 0 0 0 0 0 12.7366 0 0 0 0 0 0 0 0 A0A8I3PQT1 A0A8I3PQT1_CANLF Zinc finger protein 358 ZNF358 Canis lupus familiaris (Dog) (Canis familiaris) ATAHIYHVN;RSSSPAPA 2 3.5 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.52058 0 0 0 A0A8I3PQT2 A0A8I3PQT2_CANLF COP9 signalosome complex subunit 3 COPS3 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] LILLGKVQQLPKYTS 1 4.3 0.95171 0.053874 0 4.05745 0 0 0 0 0 0 0 0 0 0 0 0 4.60086 A0A8I3PQT6 A0A8I3PQT6_CANLF Nuclear autoantigenic sperm protein AKR1A1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAPEGLNEAKVAS;EEGKSVCGTDVQDEC;GLAYGYNSQYDEAV;LVSADKGKKYGE;VEQQTNVEELTETKDGS 5 9.7 0.98427 -0.25511 0 0 0 10.079 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQT7 A0A8I3PQT7_CANLF Potassium voltage-gated channel modifier subfamily G member 1 KCNG1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] CDDYDVTCNEFFFDRHPGAFG;LREEEEQGQCSQM;LVLRVLRAL;VGLVLRVLRALRILYV;VGLVLRVLRALRILYVM;VLRVLRALRIL;VLRVLRALRILYV 7 9.8 1.0014 -0.6423 4.50862 11.3449 0 5.0468 0 0 0 0 3.16504 0 0 0 0 0 0 A0A8I3PQU1 A0A8I3PQU1_CANLF Dachshund family transcription factor 2 Canis lupus familiaris (Dog) (Canis familiaris) NHHPGSQASSHP;TPTGITAAAMAEAMKLQ;VQGGNYYCLA 3 9.2 0.99472 -0.12622 0 0 0 9.14218 0 10.3912 10.9419 10.5394 4.29146 0 0 8.66505 0 0 0 A0A8I3PQU2 A0A8I3PQU2_CANLF Dishevelled segment polarity protein 1 DVL1 Canis lupus familiaris (Dog) (Canis familiaris) axon extension [GO:0048675]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; negative regulation of protein phosphorylation [GO:0001933]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prepulse inhibition [GO:0060134]; presynapse assembly [GO:0099054]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle exocytosis [GO:2000300]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synaptic vesicle exocytosis [GO:0016079] clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; neuronal dense core vesicle [GO:0098992]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; Wnt signalosome [GO:1990909] beta-catenin binding [GO:0008013]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901] PRYGTSPCSSAVTR 1 2 0.98485 -0.24673 0 0 0 0 0 0 12.2933 0 0 0 0 0 0 0 0 A0A8I3PQV2 A0A8I3PQV2_CANLF ATP binding cassette subfamily F member 3 ABCF3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EGGFDQYRALL 1 1.6 0.97883 0.035491 0 0 0 0 0 0 0 0 0 0 0 9.89892 0 0 0 A0A8I3PQW2 A0A8I3PQW2_CANLF T-cell leukemia translocation-altered gene protein homolog TCTA Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of osteoclast differentiation [GO:0045671]; osteoclast fusion [GO:0072675] membrane [GO:0016020] RVTLFKLLLLWLVISLLGIQ 1 19 0.97378 0.048206 0 0 0 0 0 0 8.33208 0 0 0 0 0 0 0 0 A0A8I3PQW9 A0A8I3PQW9_CANLF chymotrypsin (EC 3.4.21.1) LOC479649 Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] DAVPGSWPWQVSL;GDSGGPLVCQKDGA;IAKVFKNPK;SGGPLVCQKDGAWTLVGIVSWGS;SSCFSCCG 5 21.4 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 6.77663 0 0 0 A0A8I3PQX2 A0A8I3PQX2_CANLF Ermin (Juxtanodin) ERMN Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; morphogenesis of a branching structure [GO:0001763]; regulation of cell projection organization [GO:0031344]; regulation of cell shape [GO:0008360] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; glial cell projection [GO:0097386]; internode region of axon [GO:0033269]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; paranode region of axon [GO:0033270] actin filament binding [GO:0051015] EQEVWDEEINDDDDDCNDDEDEV;NDDDDDCNDDEDE 2 8.1 0.93505 0.10581 0 0 4.89433 0 8.24774 0 0 0 0 0 0 0 0 0 0 A0A8I3PQX6 A0A8I3PQX6_CANLF Uncharacterized protein LOC119868495 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] GVRDLPSPSSA;PTLCQKQQ;YNNWSEQVSSGI 3 5.3 1.0019 -1.3108 0 10.214 0 0 7.82439 0 0 0 0 0 0 0 0 0 0 A0A8I3PQY1 A0A8I3PQY1_CANLF Zinc finger protein 219 ZNF219 Canis lupus familiaris (Dog) (Canis familiaris) limb bud formation [GO:0060174]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PLHTRPAEGP;PLRAAGSASAAARAPQPP;TLRNGRGGEAEPLDLSL 3 6.3 0.99451 -0.1643 7.59552 0 0 0 0 0 9.34236 0 0 0 0 10.971 0 11.7426 0 A0A8I3PQY4 A0A8I3PQY4_CANLF Mitochondria localized glutamic acid rich protein MGARP Canis lupus familiaris (Dog) (Canis familiaris) anterograde axonal transport [GO:0008089] axon cytoplasm [GO:1904115]; mitochondrion [GO:0005739] ACAGDDLQEEARG;KLPGPSGSNMIYY 2 11.5 0.92094 0.11928 0 0 4.83167 10.166 0 0 0 0 0 0 0 3.91695 0 0 0 A0A8I3PQZ0 A0A8I3PQZ0_CANLF Adhesion molecule with Ig like domain 3 AMIGO3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; positive regulation of synapse assembly [GO:0051965] APLSRLRALRL;HGLGTTHLRTL;KNGLYLHNNP 3 6.3 0.99059 -0.53678 0 4.19085 0 0 0 0 0 0 0 0 9.86564 0 0 0 0 A0A8I3PQZ1 A0A8I3PQZ1_CANLF Mitotic checkpoint protein BUB3 BUB3 Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; meiotic cell cycle [GO:0051321]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501] bub1-bub3 complex [GO:1990298]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654] ubiquitin binding [GO:0043130] LSSIEGRVAVEY;TEHPEDGIFIRQVTDAETKPN 2 9.7 0.93591 0.098902 0 0 0 0 0 0 0 4.48382 0 0 0 0 0 6.57303 0 A0A8I3PQZ7 A0A8I3PQZ7_CANLF Replication protein A3 RPA3 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] nuclear lumen [GO:0031981] DNA binding [GO:0003677] TPCFRDLAGRQPPTRP 1 4.6 0.95086 0.0566 5.66818 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PQZ9 A0A8I3PQZ9_CANLF TRAF interacting protein TRAIP Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; signal transduction [GO:0007165] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; site of DNA damage [GO:0090734] identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630] KKDLFSSKNKLQTVYSEL;RCVGEPDEELASAFPVFIRN 2 8.1 0.98926 -0.20454 0 0 0 9.94018 0 0 0 0 0 0 0 7.5472 0 0 0 A0A8I3PR16 A0A8I3PR16_CANLF Nuclear receptor subfamily 1 group H member 3 NR1H3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] KGFFRRSVIKGA;VLLPGVDTPPESA 2 6.5 0.9935 -0.12034 0 9.83821 0 0 0 8.80361 0 0 0 0 0 0 0 0 0 A0A8I3PR19 A0A8I3PR19_CANLF Zinc finger protein 654 ZNF654 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" CEDDYEEEED;CEDDYEEEEDEEGD;DYEEEEDEEGDYEEDDYDLNQ;DYEEEEDEEGDYEEDDYDLNQET;EEEEDEEGDYEE;ICEDDYEEEEDE;ISLIDQKMPDIE;LEAHLAQK;LKKGLFFDPEF;LSKTPESSTQPS;LTICEDDYEEEEDEEGDYEEDDY;YEEEEDEEGDYEEDDYDL;YEEEEDEEGDYEEDDYDLNQETS;YNEGTSSVQNRVRFELLPIL 14 8.6 1.0021 -1.3081 10.676 7.84097 0 0 7.89191 0 11.179 4.49691 0 0 4.62211 9.55196 7.14364 4.36429 5.74798 A0A8I3PR23 A0A8I3PR23_CANLF Sorbin and SH3 domain containing 1 SORBS1 Canis lupus familiaris (Dog) (Canis familiaris) GVHVPPPG;KAQTLKELPLQ;PITYVDVIKRPL;SASMKDSESPRHFIPADYL;SEDDDSDLYSPRYS;SLSDPVSERRVGEQD;SPPPPLVPPIPEGLR;SPSPEISSELPGYLYS;SSLYVPCLSNNIC;TASPQFASHSKLFMPAPSSL 10 10.2 1.0032 -1.5546 12.2668 12.1638 0 5.75817 0 0 11.1362 0 0 0 0 0 0 7.7095 0 A0A8I3PR27 A0A8I3PR27_CANLF Fms related receptor tyrosine kinase 3 ligand FLT3LG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine activity [GO:0005125] LLLLLLLP;LLLLLLSPGLRAT;PAPQAPRLLLLLLLPVALLL;RLLLLLLL 4 11.2 0.9921 -0.27822 0 0 0 0 0 0 0 0 0 0 9.49967 0 0 0 0 A0A8I3PR30 A0A8I3PR30_CANLF ETS variant transcription factor 1 ETV1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" FDESMAYMPE;FDESMAYMPEGGCCNPHPY 2 4.3 0.98738 -0.22537 0 10.8308 0 0 0 0 0 0 0 0 0 0 0 6.60397 0 A0A8I3PR45 A0A8I3PR45_CANLF Sushi domain containing 5 SUSD5 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] hyaluronic acid binding [GO:0005540] DNCNLQQSTPES;LDGYPVTDGAWRKIEA;PSFPHTILQGRTGLEMGDELLYVCA;TVAPEVQDSF 4 10.2 0.98827 -0.47625 0 8.02142 0 0 0 0 0 0 6.84046 0 8.45742 0 0 0 8.36597 A0A8I3PR64 A0A8I3PR64_CANLF SplA/ryanodine receptor domain and SOCS box containing 2 SPSB2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] TDGARGKKG 1 3.4 1.0034 -0.80421 0 10.1925 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PR65 A0A8I3PR65_CANLF Macrophage stimulating 1 MST1 Canis lupus familiaris (Dog) (Canis familiaris) PPGLRPASV 1 2 0.99036 -0.26866 10.3311 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PR68 A0A8I3PR68_CANLF AT-rich interactive domain-containing protein 3 (ARID domain-containing protein) ARID3C Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634] chromatin binding [GO:0003682]; DNA binding [GO:0003677] EQFKQLYE;GSGISSINMALEINGV;GTEEEEDAEEDEEGEEA;PEGALGEVGTEEEED;PGQISTPGA;PHPHEWTYE;VGTEEEEDAEEDEEGEE 7 16.3 1.0019 -0.90895 12.9737 13.0034 5.95254 0 7.88118 7.41024 13.5788 13.5691 13.5095 0 0 0 0 4.36506 0 A0A8I3PR75 A0A8I3PR75_CANLF Centrosomal protein of 70 kDa CEP70 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; regulation of microtubule cytoskeleton organization [GO:0070507] centrosome [GO:0005813]; cytoplasm [GO:0005737] gamma-tubulin binding [GO:0043015] DLLFIVDTMLEEV;HHYKKKRMEQQE;IVHNPRAPVI;KTLQAIVSHFQKLFD;TVGKLCRVINENMNE 5 14.6 1.0029 -0.89439 9.54394 0 0 0 0 9.50966 0 0 0 5.87804 0 0 9.61045 7.98556 0 A0A8I3PR99 A0A8I3PR99_CANLF Kelch like family member 42 KLHL42 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of microtubule-based process [GO:0032886] Cul3-RING ubiquitin ligase complex [GO:0031463] ubiquitin-protein transferase activity [GO:0004842] WTLFETCDVHIRKQQM 1 3.2 0.95641 0.049233 0 0 0 0 0 0 0 0 9.19626 0 0 0 0 0 0 A0A8I3PRA1 A0A8I3PRA1_CANLF Glutamate receptor GRIA3 Canis lupus familiaris (Dog) (Canis familiaris) "modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]" AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; postsynaptic density membrane [GO:0098839] AMPA glutamate receptor activity [GO:0004971]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] EAFRYLRRQRV;EFRRIIEEMDRRQEKRYLIDCE;FSFLDPLAYEIWM;HYMLANLGFTDILLERVM;PPNEFGIFNSLWFS;VLRAVFLLVL 6 10.7 0.99543 -0.19038 0 0 0 7.05897 0 0 0 0 9.1749 0 0 0 0 4.79379 0 A0A8I3PRB0 A0A8I3PRB0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SSILNSDLANLGAECLQM 1 39.1 0.98003 0.048313 0 0 0 0 0 0 0 0 0 0 0 8.82464 0 0 0 A0A8I3PRB8 A0A8I3PRB8_CANLF Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) IKZF5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] LHHCQHCDMYFAD;SLSSKKMWGVL 2 5.7 0.92355 0.095052 0 9.34654 0 0 0 0 5.8716 0 0 0 0 0 0 0 0 A0A8I3PRB9 A0A8I3PRB9_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF144A Canis lupus familiaris (Dog) (Canis familiaris) pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein K6-linked ubiquitination [GO:0085020]; ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; ubiquitin ligase complex [GO:0000151] ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CIFCTLCLKQYV;RNQLNAQKPI;YPVEQMTTIAQ 3 9 1.0041 -0.81008 8.67885 0 0 0 0 0 0 0 10.7398 0 0 0 0 0 0 A0A8I3PRF0 A0A8I3PRF0_CANLF Chromosome 3 open reading frame 20 C3orf20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESSKEEHESVSVSPTR;IAKMNRAL;KKVIKLHYTFYD;KVSKKVIK;LFNDTPNFFL;PTPHQPLVYHHPHFSRHSQDWKV;STYIPGPEDPD 7 9.4 1.0019 -1.4688 12.3538 0 0 8.44265 0 0 0 0 0 0 0 0 0 5.51561 0 A0A8I3PRG4 A0A8I3PRG4_CANLF Cilia and flagella associated protein 46 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] PCATNSTSP;VGHLGNKHLPSQAEWEQL 2 7.8 1.0029 -0.7559 0 0 0 0 0 4.53094 0 0 6.9982 0 0 0 0 0 0 A0A8I3PRH7 A0A8I3PRH7_CANLF Double PHD fingers 2 DPF2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] LDDLDDEDYEE;SILEDRDKPYACDNSF;TPKRRGKG 3 8.6 0.98682 -0.50019 0 0 5.26592 0 11.0004 0 0 0 0 0 0 0 8.83627 0 0 A0A8I3PRI0 A0A8I3PRI0_CANLF Chromosome 28 C10orf95 homolog C28H10orf95 Canis lupus familiaris (Dog) (Canis familiaris) LPYAYLTG 1 3.7 1.0047 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 9.14843 0 0 A0A8I3PRI1 A0A8I3PRI1_CANLF Zinc finger protein 687 ZNF687 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAARDSPEVPAQASDHGL;AGALTSPKA;FPERDEYVAHMK;KGGGGGPG;KGGGGGPGG;LHLSRRVG;PGAGGGTV;PKTMAKNVL;REHKDKGLVMQCSHLVMRPVAL;SPKSPQSPSSGAEAADEDSNDS;STPHSPAPLSGGTWK 11 11.2 0.99736 -3.5076 0 8.0964 7.32346 0 9.16837 0 10.2642 10.6618 0 0 9.77373 8.62231 12.8778 0 0 A0A8I3PRI3 A0A8I3PRI3_CANLF Eukaryotic translation initiation factor 3 subunit M EIF3M Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translational initiation [GO:0002183] eukaryotic translation initiation factor 3 complex [GO:0005852] AASKVMVELLGSYTE 1 6.2 0.99673 -0.09619 0 0 8.51381 8.57509 7.19712 0 0 0 0 0 0 8.51735 8.46467 0 0 A0A8I3PRI7 A0A8I3PRI7_CANLF Cell division cycle 73 CDC73 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; transcription elongation by RNA polymerase II [GO:0006368] Cdc73/Paf1 complex [GO:0016593] RNA polymerase II complex binding [GO:0000993] LRVHRLVRLRLLQ;PLRVHRLVRLRLLQ;SAPLEIGLQRSTQ;SHVPLRVHRLVRLRLLQHSQ 4 8.6 0.99259 -0.049924 0 0 0 0 0 4.42055 10.0337 6.31341 0 0 0 0 0 0 0 A0A8I3PRJ1 A0A8I3PRJ1_CANLF Transmembrane protein 184B TMEM184B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IVRILFIVPIYAF;PATRTSSSVWRCS 2 5.8 0.99178 -0.27205 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.84106 A0A8I3PRJ3 A0A8I3PRJ3_CANLF "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] metal ion binding [GO:0046872] IIDAALPAVRI 1 8 0.98473 0.035491 0 0 0 0 0 0 0 0 0 6.98687 0 0 0 0 0 A0A8I3PRJ6 A0A8I3PRJ6_CANLF Uncharacterized protein LOC111092907 Canis lupus familiaris (Dog) (Canis familiaris) CDGHVIDEHF;HVIDEHFLVSR 2 8.8 1.0029 -0.86396 0 0 0 6.79779 0 0 0 0 0 0 0 0 0 10.9522 0 A0A8I3PRK6 A0A8I3PRK6_CANLF Cytoplasmic dynein 2 light intermediate chain 1 DYNC2LI1 Canis lupus familiaris (Dog) (Canis familiaris) determination of left/right symmetry [GO:0007368]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of cilium assembly [GO:1902017] apical part of cell [GO:0045177]; axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; microtubule [GO:0005874]; motile cilium [GO:0031514] dynein heavy chain binding [GO:0045504] SEKRKVICKTLRFV 1 4 0.93269 0.060773 0 0 0 0 0 0 0 0 5.40095 0 0 0 0 0 0 A0A8I3PRL1 A0A8I3PRL1_CANLF Chromosome 17 open reading frame 58 C17orf58 Canis lupus familiaris (Dog) (Canis familiaris) AAPPPEPAPAPAPA;ARRDNFERPCA;SRYIVMGHIY 3 10 0.99228 -0.54094 10.019 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PRM7 A0A8I3PRM7_CANLF Triosephosphate isomerase (EC 5.3.1.1) TPI1 Canis lupus familiaris (Dog) (Canis familiaris) canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563] cytosol [GO:0005829] lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; triose-phosphate isomerase activity [GO:0004807]; ubiquitin protein ligase binding [GO:0031625] GAPDLQCVAPSAMAPSRKF;GGEEAEFRLAALYISGQWQ 2 13.3 0.98874 -0.21799 0 0 8.70712 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PRM8 A0A8I3PRM8_CANLF Methanethiol oxidase (MTO) (EC 1.8.3.4) (Selenium-binding protein 1) SELENBP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] methanethiol oxidase activity [GO:0018549]; selenium binding [GO:0008430] PNFLVDFGKEPLGP;RQYDISDPQRPRL;VGCALSST 3 8.5 1.0034 -1.5712 0 0 0 0 0 0 0 10.5512 7.87609 9.54541 0 0 0 0 0 A0A8I3PRN0 A0A8I3PRN0_CANLF Uncharacterized protein PPP1R3F Canis lupus familiaris (Dog) (Canis familiaris) regulation of glycogen biosynthetic process [GO:0005979] membrane [GO:0016020] glycogen binding [GO:2001069]; protein phosphatase binding [GO:0019903] ADEDDDGEDGDEGEEEEEACPAPSP;AGQDGDGGGADEDDDGEDGDE;DDDGEDGDEGEEEEE;DGDGGGADEDDDGEDGDEGEEEE;EDDDGEDGDEGEEEEEACPA;GGGGEGPTDGGV;SPPGAGAG 7 6.7 0.87771 0.13814 9.15193 0 0 5.74198 0 0 0 0 6.0654 3.0668 9.7471 0 9.36779 0 0 A0A8I3PRN8 A0A8I3PRN8_CANLF H6 family homeobox 2 HMX2 Canis lupus familiaris (Dog) (Canis familiaris) "brain development [GO:0007420]; epithelial cell proliferation [GO:0050673]; inner ear morphogenesis [GO:0042472]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of stem cell proliferation [GO:2000648]; stem cell proliferation [GO:0072089]" nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" FPCLGTPKGGGGAGPASS 1 6.6 0.99321 -0.031763 0 0 0 0 0 0 0 0 10.6558 0 0 0 0 0 0 A0A8I3PRN9 A0A8I3PRN9_CANLF Alcohol dehydrogenase E chain LOC100856533 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] EAAGIVESIGEG;GVPPNSQSLSMNPML;VVPLPIIL 3 10.4 0.9876 -0.46485 9.19508 0 0 0 0 0 0 0 0 0 6.96509 0 0 0 8.41587 A0A8I3PRQ5 A0A8I3PRQ5_CANLF Uncharacterized protein HIC2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AYETGSGGAEEEAE;DEGEGLGDRVPN;HSKQLLLQLN;TEEELFIKEEGAYETG 4 7.6 0.98779 -0.4673 7.08704 0 0 0 0 0 0 0 0 0 10.8752 0 0 0 9.33007 A0A8I3PRQ6 A0A8I3PRQ6_CANLF Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) LOC100855486 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] mitochondrial outer membrane [GO:0005741] PVVFETEKLQMEQQQ 1 10.7 0.956 0.053874 7.55896 0 0 0 0 8.21902 0 8.26674 0 0 0 0 9.2999 0 0 A0A8I3PRS3 A0A8I3PRS3_CANLF Gamma-aminobutyric acid type A receptor subunit alpha3 GABRA3 Canis lupus familiaris (Dog) (Canis familiaris) "gamma-aminobutyric acid signaling pathway [GO:0007214]; nervous system process [GO:0050877]; regulation of postsynaptic membrane potential [GO:0060078]; signal transduction [GO:0007165]; synaptic transmission, GABAergic [GO:0051932]" dendrite membrane [GO:0032590]; GABA-A receptor complex [GO:1902711]; postsynapse [GO:0098794] benzodiazepine receptor activity [GO:0008503]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; inhibitory extracellular ligand-gated monoatomic ion channel activity [GO:0005237] IPSVVWYPLMFSSRSL 1 4.6 0.99762 -0.10445 0 0 0 0 0 0 0 0 0 0 0 8.88457 0 0 0 A0A8I3PRS5 A0A8I3PRS5_CANLF D-amino acid oxidase DAO Canis lupus familiaris (Dog) (Canis familiaris) D-amino acid metabolic process [GO:0046416] D-amino-acid oxidase activity [GO:0003884]; FAD binding [GO:0071949] FRRLTRRELDMFP;HQWQRISLDPRSCLYVKTKPAL;LEVDVVCW;LLSHIHSPN 4 12.8 1.002 -1.8021 0 0 10.095 0 7.52724 0 0 8.0641 0 0 0 0 0 0 0 A0A8I3PRS9 A0A8I3PRS9_CANLF BCL6 corepressor LOC119868783 Canis lupus familiaris (Dog) (Canis familiaris) ILNDPTLQLDRKRKLSGN;IMNMTHSELMKM;LCTDEKDRQAASVLQK;LEKWSPSHETAPY;LEVSTPFLEPA;LYPRSYIPF;NISHASYLQLPW;NMNKTLQPQQSCNLARPL;SPDISPLVHC;VGDQFKCVTTELY 10 8.2 1.0021 -1.4075 8.77212 0 0 11.3608 0 0 0 0 10.7231 14.1363 8.86805 8.67811 0 0 0 A0A8I3PRT2 A0A8I3PRT2_CANLF SH2 domain containing 1B SH2D1B Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376] SESLPGVLCLCVSFKN 1 11.1 0.96178 0.049233 0 0 0 0 0 0 7.23419 0 0 0 0 0 0 3.92657 0 A0A8I3PRU8 A0A8I3PRU8_CANLF Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113] cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644] DGLLCTSLPVWLDN;DLAGFAVG;DLTEQILKDIKQHK;EAQALGLEVFHAGTA;GVTVTGCTVHFVAEDV;KDIKQHKEEAW 6 7 1.0032 -2.149 0 14.0678 0 0 9.65732 0 10.538 9.15386 0 0 0 0 0 0 0 A0A8I3PRV7 A0A8I3PRV7_CANLF "Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] TLYFGSGL 1 11.8 1.0039 -1.1044 7.11738 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PRW4 A0A8I3PRW4_CANLF MID1 interacting protein 1 MID1IP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of fatty acid biosynthetic process [GO:0045723]; protein polymerization [GO:0051258] cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634] identical protein binding [GO:0042802] EAGEEDLEQQFHYHLRGLHSV;EDLEQQFHYH;EERTPPAP;SIRNDIEWGVL 4 21.9 1.0038 -1.0382 0 0 0 6.79077 0 0 0 9.85647 0 0 0 0 0 7.54982 7.56384 A0A8I3PRW6 A0A8I3PRW6_CANLF small monomeric GTPase (EC 3.6.5.2) MTFMT Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] KLVTVKSSRAQSKRK;TPRNCERYLNWAHAF 2 12.1 0.92963 0.10778 0 0 7.15066 0 8.27771 0 0 0 0 0 7.85156 0 0 0 0 A0A8I3PRW7 A0A8I3PRW7_CANLF Centromere protein P CENPP Canis lupus familiaris (Dog) (Canis familiaris) CENP-A containing chromatin assembly [GO:0034080] "chromosome, centromeric region [GO:0000775]" ANTQTQSRLH;MGVRSACQPGFELVVVW 2 8.9 0.98529 -0.44043 0 0 10.2178 0 11.352 0 0 0 0 0 0 0 0 0 0 A0A8I3PRX3 A0A8I3PRX3_CANLF Sodium- and chloride-dependent GABA transporter 2 (Solute carrier family 6 member 13) SLC6A13 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] ALVDMYPHIFR;RWELALCLLVAWVICYFCIWKG;TSENATSPVIEFWER 3 9.4 0.98921 -0.3039 10.8433 10.5496 0 0 8.65832 8.39836 11.4559 11.7794 12.0685 0 0 0 9.96434 0 9.2525 A0A8I3PRZ1 A0A8I3PRZ1_CANLF UBC core domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPLVGSIATHYLTNRA 1 17.4 0.95985 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.18884 A0A8I3PRZ3 A0A8I3PRZ3_CANLF Isthmin 1 ISM1 Canis lupus familiaris (Dog) (Canis familiaris) AELLLLLGLLLLTLHITV;GHRTFEAKEQP;QPFPRQRFQQEPG;WMSCKSEFLQ 4 12 1.004 -1.1001 0 0 0 4.06695 0 0 9.32355 0 0 0 0 0 8.67733 0 0 A0A8I3PS19 A0A8I3PS19_CANLF Zinc finger protein 609 ZNF609 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291] nucleoplasm [GO:0005654] promoter-specific chromatin binding [GO:1990841] AALKEEWKQKPS;AHTDDDSKPEADGDSEYGEEP;GSCSSVGG;GVDANPVE;GVNTCDVA;KEVQGRSGDGANAGSL;LDDSSKLPSQ;LEGIVWQETEDGMLVVNVTWRNKT;NCPSPVLIDCPHPNCNKKY 9 8.9 0.99709 -3.9599 8.6697 0 10.9593 0 0 0 0 9.70974 11.7091 0 0 6.23728 6.55963 9.77255 0 A0A8I3PS26 A0A8I3PS26_CANLF Granzyme A GZMA Canis lupus familiaris (Dog) (Canis familiaris) cytotoxic T cell pyroptotic cell death [GO:1902483]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; positive regulation of apoptotic process [GO:0043065]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603] cytoplasm [GO:0005737] protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252] DLKLLQLKKKAKVNKKVSILR;LKKKAKVNKKVSILRLPKRGD 2 10 0.93248 0.094332 0 0 0 0 0 0 7.60311 0 0 0 0 0 5.4649 0 0 A0A8I3PS31 A0A8I3PS31_CANLF MSL complex subunit 3 MSL3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] MSL complex [GO:0072487]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H4K16 acetyltransferase activity [GO:0046972]; methylated histone binding [GO:0035064] DEKGRKIPEYLIHFN;NAAFSANER;RRLQRKLARKAVARLRSTGR;SEYLGRWWTFF;VLSWKLVPD;YLIHFNGWNRSWDRW 6 13.8 0.98915 -0.51842 9.9579 9.23175 7.56217 0 0 10.4283 0 10.4289 10.3794 2.77275 9.57582 5.2474 9.11941 8.67497 4.04492 A0A8I3PS37 A0A8I3PS37_CANLF Galanin peptides LOC119868797 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] hormone activity [GO:0005179] SDLPDLPSAVS 1 3.5 0.99167 0.008402 0 0 3.34355 0 0 0 0 9.99901 0 0 9.67255 0 0 0 0 A0A8I3PS39 A0A8I3PS39_CANLF Metalloendopeptidase (EC 3.4.24.-) TLL2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of skeletal muscle tissue growth [GO:0048632]; proteolysis [GO:0006508] extracellular space [GO:0005615] calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270] ADCGYDYMEAYDGYDS;EAGKDGEENAMLLHSP;EATCGGDI;EEEADCGYDYME;EFEIEQHQ;GGDINKDAGQIQ;MRVEFKSDNTVSKRGFRAHFFS;TDEESFIVFSY;VVASGSSL 9 9.8 1.0034 -2.2255 6.61789 0 0 0 8.21018 8.31529 14.2323 13.9452 13.9623 0 11.4063 0 13.4666 0 0 A0A8I3PS49 A0A8I3PS49_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EVGEVGAQPPGQ 1 16.4 0.98854 -0.26067 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.239 A0A8I3PS50 A0A8I3PS50_CANLF "Mucin 13, cell surface associated" MUC13 Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] NSYHHISSY;SLNSTYFCLCFFG;WSCIFVFNVV 3 5.5 1.004 -0.80421 0 0 0 0 0 0 0 0 0 0 0 6.30685 0 0 0 A0A8I3PS62 A0A8I3PS62_CANLF Inka box actin regulator 1 INKA1 Canis lupus familiaris (Dog) (Canis familiaris) neural tube development [GO:0021915] nucleus [GO:0005634] protein serine/threonine kinase inhibitor activity [GO:0030291] RSPREHALDW 1 3.6 0.99892 -0.61146 0 0 0 0 0 0 5.71504 0 0 0 0 0 0 0 0 A0A8I3PS67 A0A8I3PS67_CANLF T-box transcription factor 5 TBX5 Canis lupus familiaris (Dog) (Canis familiaris) atrial septum morphogenesis [GO:0060413]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular valve morphogenesis [GO:0003181]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; cardiac left ventricle formation [GO:0003218]; cardiac muscle cell proliferation [GO:0060038]; cell-cell signaling involved in cardiac conduction [GO:0086019]; embryonic forelimb morphogenesis [GO:0035115]; endocardial cushion development [GO:0003197]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; pattern specification process [GO:0007389]; pericardium development [GO:0060039]; positive regulation of cardiac conduction [GO:1903781]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; sinoatrial node development [GO:0003163]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281] cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" AGMANHGS;ASSNLGSQYQCENGV;LEDISCNT;TQLKIENNPFAKGF 4 8.7 1.0014 -1.81 8.6864 0 0 0 0 0 8.09861 0 0 0 10.5018 0 0 0 11.1229 A0A8I3PS72 A0A8I3PS72_CANLF Prohibitin PHB2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005] mitochondrial inner membrane [GO:0005743] DYEERVLPSI;LDYEERVLPSIVNE;VLSRPNAMELPSMYQRL 3 11.9 0.99417 -0.55867 11.8263 11.7329 8.64126 0 0 0 10.4187 0 13.0177 0 0 0 0 0 0 A0A8I3PS85 A0A8I3PS85_CANLF Stromal cell derived factor 2 like 1 SDF2L1 Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] endoplasmic reticulum chaperone complex [GO:0034663]; protein folding chaperone complex [GO:0101031] misfolded protein binding [GO:0051787] AGAMWSAGRGRAAGP;GVEASDDA;IGYLHWFCQ 3 9.8 1.003 -1.6601 0 0 0 0 8.69077 0 0 0 0 0 0 7.54512 0 0 0 A0A8I3PS88 A0A8I3PS88_CANLF Solute carrier family 5 member 5 SLC5A5 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] LPSSSAGCAVPSANA;VLSAAGCGIIMFAIYIDCDPLLAG 2 6.3 0.98941 -0.22244 0 0 0 0 0 0 0 0 12.0217 0 8.286 0 0 0 0 A0A8I3PS91 A0A8I3PS91_CANLF Tensin 1 TNS1 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925] phosphoprotein phosphatase activity [GO:0004721] HYFSGLLSGSIKM;KVSSSPVASGMSSPSGG;PAPLRRRAA;PGLERHAAYGGY;PSSHELVGT;PSTANEENFRS 6 3.9 1.0039 -0.80421 0 0 13.1885 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PS94 A0A8I3PS94_CANLF E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313) RNF114 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283] cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] VATCSKYQNYIMEGVKA 1 7.5 0.97876 0.046227 0 0 0 0 0 0 0 6.12897 0 0 0 0 0 0 0 A0A8I3PS95 A0A8I3PS95_CANLF Aconitate decarboxylase 1 ACOD1 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; positive regulation of antimicrobial humoral response [GO:0002760]; tolerance induction to lipopolysaccharide [GO:0072573] aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803] ALSEALPSSQKFS;VLTTLLKGP 2 4.7 1.0034 -1.1197 0 0 0 0 0 0 0 0 0 0 0 3.79202 0 0 0 A0A8I3PS99 A0A8I3PS99_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) ZRANB1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872] FTLPADIEDLPPTVQEKLF;LREWLDCCVTEGGVLVAMQKS;QSFGLHFSLREEQWQEDWAFILS;SLSDGEEDEDEED;WACEYCTYENWPSAI 5 12.4 0.99486 -0.19049 12.7243 0 0 0 0 0 0 9.80366 0 0 0 0 0 0 11.6083 A0A8I3PSA4 A0A8I3PSA4_CANLF tRNA-dihydrouridine synthase (EC 1.3.1.-) DUS4L Canis lupus familiaris (Dog) (Canis familiaris) flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150] PYMCFHQHLMYMMEKITSRQEKRVF 1 7.9 0.9791 0.035538 0 0 5.71959 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PSB1 A0A8I3PSB1_CANLF GRIP and coiled-coil domain containing 1 GCC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ELQALREEKNRPD;ENQISEVSELL;GLTGVQPPGLSFP;LEASIKVLSVSHE;VGLTGVQP;VLSVSHEADVGLTGVQPPGLS 6 6.8 1.0025 -1.7651 9.62901 0 0 9.78485 0 0 0 11.3246 0 0 0 8.82101 0 0 10.7645 A0A8I3PSB6 A0A8I3PSB6_CANLF Lysosomal acid phosphatase (EC 3.1.3.2) ACP2 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765] GSILFLLIVLLLT;LFPPNGMQRFNPNISWQPIPV;LLTVLFRMQAQPPG;TLEGMLQHWELGQALRQ 4 15.9 0.9736 0.03573 0 0 8.91722 0 0 0 0 0 7.18963 4.72699 0 0 0 0 0 A0A8I3PSB9 A0A8I3PSB9_CANLF Kelch-like protein 21 KLHL21 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465] Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; polar microtubule [GO:0005827] cullin family protein binding [GO:0097602]; ubiquitin-protein transferase activity [GO:0004842] CDQDCDELVTVDCYNPQ;GGCDQDCDE;GGCDQDCDELVTVDCYN;STERYDHTTDSWEA;VGGCDQDCD;YLAEFPDHLGGGYS 6 8 1.0024 -1.1697 0 9.46369 0 0 0 0 8.72018 0 0 6.808 0 0 7.12329 7.83977 5.33289 A0A8I3PSC8 A0A8I3PSC8_CANLF Wiskott-Aldrich syndrome protein family member (WASP family protein member) WASF3 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601] cytoskeleton [GO:0005856]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209] actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237] EVSLQDINMKKAF;QQPPPPPPPQ;SYTAPPHPP;YSDSDDDSEF 4 8.4 1.0027 -1.005 0 8.50728 0 0 0 0 0 0 0 0 0 10.6181 0 3.03951 0 A0A8I3PSD1 A0A8I3PSD1_CANLF Secreted phosphoprotein 24 (Secreted phosphoprotein 2) SPP2 Canis lupus familiaris (Dog) (Canis familiaris) bone remodeling [GO:0046849] extracellular region [GO:0005576] QSLSPYLFRAFR 1 6 0.99094 -0.26791 0 0 0 0 0 0 10.2109 0 0 0 0 0 0 0 0 A0A8I3PSD9 A0A8I3PSD9_CANLF Zinc finger PHD-type domain-containing protein PHF13 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DSCSGWDSD;GPVVRVPRRN;LKKKKKRKR;RKKTDKLKKKKKRKRRDS;SNFLLDRKKTDKLKKKKKRKRRDSD;TDKLKKKKKRKR;VTCFCMKPF 7 15.1 0.99107 -0.27591 0 0 0 0 0 0 0 0 0 0 11.2972 0 0 0 0 A0A8I3PSE0 A0A8I3PSE0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF34 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872] ANTEEEDDEDDDEDDEDDDDEE;CCDCKKDFCSVCS;DDDEDDEDDDDEENL;DEDDEDDDDEENLE;EDDEDDDEDDEDDDD;EEDDEDDDEDDEDDDD;IASANTEEEDDEDDDEDDEDDDDE;NTEEEDDEDDDEDDED;NTEEEDDEDDDEDDEDDDD;SANTEEEDDEDDDEDD;TEEEDDEDDDEDD;VQSEIASANTEEEDDEDDDEDDEDD 12 12.1 0.97326 0.046767 9.21216 8.99822 7.35641 7.91379 4.59126 0 6.89567 0 0 6.53966 0 6.54588 7.72458 8.13181 0 A0A8I3PSE2 A0A8I3PSE2_CANLF E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (RING-type E3 ubiquitin transferase MARCHF8) MARCHF8 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DTGTEIVH;FCSDEMGDDD;HVIAITCVVWSLY;LYVLIDRTTEEI;PVSTSGDACRICHCEGDEES 5 10.7 1.0026 -1.3249 0 0 0 6.36345 0 14.6353 0 0 8.60685 7.46923 0 0 7.23343 0 0 A0A8I3PSE4 A0A8I3PSE4_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A2 Canis lupus familiaris (Dog) (Canis familiaris) ligase activity [GO:0016874] GNGLREDVWREF;IPESWRSEVTFSAPALYIYTSGTTG 2 6.5 0.98808 -0.22412 0 0 0 0 0 0 7.51215 0 0 0 7.6737 0 0 0 8.72976 A0A8I3PSE7 A0A8I3PSE7_CANLF polo kinase (EC 2.7.11.21) PLK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AGCQSPRPFPRAAAPPA;EQNPAPLAQPEPLVWVSKWVDYSNK;TERESPQRASRSPGR;VGAVPPAL 4 8.9 0.99258 -0.55335 0 0 11.0666 11.969 0 11.9183 0 0 0 0 0 0 0 7.38629 12.0106 A0A8I3PSF1 A0A8I3PSF1_CANLF CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) MNAT1 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289] transcription factor TFIIH holo complex [GO:0005675] cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; metal ion binding [GO:0046872] LEEALEVERQENEQRRLF 1 6.7 0.98314 -0.25599 0 0 0 0 9.80142 0 0 0 0 0 0 0 0 0 0 A0A8I3PSH0 A0A8I3PSH0_CANLF Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) PPIP5K1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate kinase activity [GO:0000828] DVVIPQEYGIS;EVYRILQE;GNCPFGFSDQPSVSSH;GRRRRRSGDLP;LDLIPLRGRRRRRSG;LPLLRKILLDLQ;QDAPFGPEDYDQLAP;QEFPGEDDLQVQEVPE;QFQIPWSIPTEAEDIP;QLAPTGSTSLLNSMAV;RHGDRTPKQKMK;TAVDGNCPFGFSD;VIPQEYGISREEKLEIA;VSTTHLASCT 14 10.5 0.99884 -2.9816 0 0 10.4324 10.6316 0 2.72792 0 6.76752 0 7.16922 0 13.3582 0 8.01714 0 A0A8I3PSH1 A0A8I3PSH1_CANLF ADP ribosylation factor like GTPase 4C ARL4C Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886] cytosol [GO:0005829]; plasma membrane [GO:0005886] alpha-tubulin binding [GO:0043014]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] EMILKRRKSLKQKKKRARSS;PVAEIEKQLALHELIPATTYHVQP 2 21.3 0.98554 -0.24102 0 0 0 0 9.39763 0 0 0 0 0 0 0 0 0 5.56888 A0A8I3PSH2 A0A8I3PSH2_CANLF Cleavage stimulation factor subunit 3 CSTF3 Canis lupus familiaris (Dog) (Canis familiaris) "co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]" mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654] mRNA binding [GO:0003729] FAYADYEESRMKYE;MIFKKAREDTRTRHHVY;PEYPKPDTQ;QNTPQEAQQVDMW 4 7.4 1.0011 -0.63749 4.20273 3.91485 0 0 0 6.73944 0 0 9.91102 9.02918 0 0 9.7685 0 0 A0A8I3PSJ3 A0A8I3PSJ3_CANLF Tubulin delta chain (Delta-tubulin) TUBD1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030]; microtubule-based process [GO:0007017] centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200] ISFSDINQVLAHQLG;QCGNQIGFEVFDALYSDSHCPQGLC 2 11.4 0.9163 0.11855 0 8.81813 0 0 0 0 0 9.56729 0 0 0 0 0 0 0 A0A8I3PSJ6 A0A8I3PSJ6_CANLF TBC1 domain family member 13 TBC1D13 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] GTPase activator activity [GO:0005096] ELSFSGIPCEGGLRCL 1 5.8 0.98407 -0.25535 0 0 0 0 0 0 0 9.71493 0 0 0 0 0 0 0 A0A8I3PSJ7 A0A8I3PSJ7_CANLF Transmembrane protein 266 TMEM266 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated channel activity [GO:0022832] ATILKEEEG;DLLSSPLEGPCP;GVPEPAACVVTTAAID;LSSPLEGPCP 4 5.8 0.98405 -0.24367 0 0 0 0 0 13.0812 0 0 0 0 0 0 0 0 0 A0A8I3PSK0 A0A8I3PSK0_CANLF Zinc finger protein 699 ZNF699 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LGYPLHTPYLISQWKQE;YHDTYYQNKSH 2 4.4 0.97715 0.04739 0 0 0 0 0 0 0 0 10.9033 0 0 0 0 0 0 A0A8I3PSK4 A0A8I3PSK4_CANLF Prothymosin alpha Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DSEVDEEEEEGGEEEEEEGDGEE 1 20.9 0.97836 0.046253 0 0 0 0 5.84461 0 0 0 0 0 0 0 0 0 0 A0A8I3PSM1 A0A8I3PSM1_CANLF Uncharacterized protein TEX13D Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] MVHLGASGS 1 1.3 0.98272 -0.25143 0 0 0 0 0 0 8.69519 0 0 0 0 0 0 0 0 A0A8I3PSM5 A0A8I3PSM5_CANLF Bestrophin BEST4 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; intracellularly calcium-gated chloride channel activity [GO:0005229] IEEASVGS;LPDQLMCVIS;TQVVTIAVYSFFG 3 6.6 1.0034 -1.1156 0 9.09816 0 8.65435 0 0 0 0 0 0 0 12.0325 0 0 0 A0A8I3PSM7 A0A8I3PSM7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) QSAGCPGAPTQSAGCPGAPSQ;VGGVSPVC 2 3.5 0.98948 -0.21714 11.6298 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PSN7 A0A8I3PSN7_CANLF Importin subunit alpha KPNA1 Canis lupus familiaris (Dog) (Canis familiaris) NLS-bearing protein import into nucleus [GO:0006607]; postsynapse to nucleus signaling pathway [GO:0099527]; regulation of apoptotic process [GO:0042981]; regulation of canonical Wnt signaling pathway [GO:0060828]; satellite cell activation involved in skeletal muscle regeneration [GO:0014901]; skeletal muscle satellite cell proliferation [GO:0014841] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] DSTMCRDYVL;EEAYGLDKIEFLQSHENQEIY;EQKKKKKKKKKRIMKLFKRR;EQKKKKKKKKKRIMKLFKRRNV;ETEEEVMSDGGFHEAQ;KKKKKKKK;KKKKKKKKKRI;KKKKKKKKKRIMKLFK;KKKKKKKKKRIMKLFKR;KKKKKKKKRIMK;KREEQKKKKKKKKKRIMKLFKRRNV;LADACWALSYLSDG;LSKEPNPPID;QKKKKKKK;QKKKKKKKKKRI;QKKKKKKKKKRIMKLFKRRN;QKREEQKKKKKKKKKRIM;RKQKREEQKKKKKKKKKRIMKLFK;SDGGFHEAQINNMEM 19 19.1 0.98731 -0.3988 0 0 8.07211 0 7.50661 3.13281 4.75782 9.58308 8.85203 0 8.0468 10.6332 6.95594 8.41777 0 A0A8I3PSN8 A0A8I3PSN8_CANLF Glutamate metabotropic receptor 8 GRM8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] GVEAFTQISREIGGV;IIKRLLETPNARAVI;KRSASCPC;TAKFYWILTMMQ 4 5.8 0.98931 -0.30478 7.03991 7.7666 0 0 0 0 0 0 7.13072 0 7.59373 6.50322 0 9.4709 0 A0A8I3PSP2 A0A8I3PSP2_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP9 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GVSGVIPP;PPLLLLLL 2 3.5 1.0048 -1.1044 0 0 8.65928 0 0 0 0 0 11.3946 8.00388 7.99966 8.00748 0 0 0 A0A8I3PSP6 A0A8I3PSP6_CANLF "Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" PREX1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] AALHCLGV;EINTQSLEKVQQYY;GVAITGATGLEK;LPSRLEGGASL;SILIWDSELWNLGM 5 4.4 1.002 -1.0156 0 0 0 0 0 6.63011 7.28771 0 0 0 0 0 0 0 0 A0A8I3PSQ8 A0A8I3PSQ8_CANLF E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) MID1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of microtubule cytoskeleton organization [GO:0070507] cytoplasm [GO:0005737]; microtubule [GO:0005874] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] AQQIANCKQCIER;EDPLLLPCAHSLCFN;QPVCPTFTVWNKCLT;TVHWTSDDEF;WEVVISGSTWYA 5 10.2 1.0033 -1.0568 0 8.84718 0 0 7.51861 0 0 0 0 0 0 0 0 7.20438 0 A0A8I3PSR7 A0A8I3PSR7_CANLF Aldehyde dehydrogenase LOC119868887 Canis lupus familiaris (Dog) (Canis familiaris) cellular aldehyde metabolic process [GO:0006081]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" GVEETTELLKQRFDHI;IAAGNAVIIKP;MLDEAYVQPEPLG;PATHGKGP 4 10.2 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 8.69867 0 0 0 0 A0A8I3PSS1 A0A8I3PSS1_CANLF Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) SIGMAR1 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; protein homotrimerization [GO:0070207]; regulation of neuron apoptotic process [GO:0043523] cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; postsynaptic density membrane [GO:0098839] signaling receptor activity [GO:0038023] RRWAWAALLLAAAAVLAQVVWL;SEVFYPGE 2 13.5 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.04663 0 0 0 A0A8I3PSS2 A0A8I3PSS2_CANLF Sodium channel and clathrin linker 1 SCLT1 Canis lupus familiaris (Dog) (Canis familiaris) clustering of voltage-gated sodium channels [GO:0045162] KQLHVTKE;NVEIEQLRKQLRSEL 2 8.1 0.95051 0.053897 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.25792 A0A8I3PSS3 A0A8I3PSS3_CANLF E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (RING finger and transmembrane domain-containing protein 1) RNFT1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERAD pathway [GO:1904294] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] VGITDFILKFL 1 2.8 0.98262 -0.25153 0 0 0 0 0 0 0 14.4024 0 0 0 0 0 0 0 A0A8I3PSS6 A0A8I3PSS6_CANLF Plasmanylethanolamine desaturase 1 PEDS1 Canis lupus familiaris (Dog) (Canis familiaris) ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789] plasmanylethanolamine desaturase activity [GO:0050207] GVVAGALI;PRWVTLLQDWHIILPRKHHRIHH 2 11.4 1.0035 -1.0581 0 0 0 0 0 0 0 0 0 0 0 0 8.28313 4.10534 0 A0A8I3PST2 A0A8I3PST2_CANLF Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) MAPRE1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225] centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; microtubule plus-end [GO:0035371]; spindle midzone [GO:0051233]; spindle pole [GO:0000922] microtubule plus-end binding [GO:0051010] DMLAWINESL;VEDLEKERDFYFGKLRNIELICQ;VQWFKKFF 3 15.3 0.99279 -0.27864 0 0 0 0 0 0 0 10.195 0 0 0 0 0 0 0 A0A8I3PST7 A0A8I3PST7_CANLF Programmed cell death 7 PDCD7 Canis lupus familiaris (Dog) (Canis familiaris) U12-type spliceosomal complex [GO:0005689] GEARRRLERVRRRRLRLRERA;GGGGGGSG;HHLQRLRKLIKKRS;LVPSDHPKGNSVPQG;MCFLSQTRSFTR;VDILRALEKLRKLRKEAA;VGEARRRLERVRRRRLRLRERARER 7 16 0.99572 -0.016357 0 0 0 8.78113 0 0 0 0 0 0 4.14853 13.6607 6.10144 3.96172 10.1328 A0A8I3PSU3 A0A8I3PSU3_CANLF Solute carrier family 49 member 4 SLC49A4 Canis lupus familiaris (Dog) (Canis familiaris) pyridoxine transport [GO:0031923] lysosomal membrane [GO:0005765] GVLLFFLTFYHTELSWFNWCLPGS;VPEGITCGVVTFLSNMFMG;WGPIGFLPCFAFMWL 3 12 0.99207 -0.54334 0 0 10.1335 0 0 10.2238 0 0 0 0 0 0 0 0 0 A0A8I3PSU5 A0A8I3PSU5_CANLF Hyperpolarization activated cyclic nucleotide gated potassium channel 4 HCN4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] AAGPRRRDG;FTKILSLLRLLRLSRLIRY;GAGGGGGG;IVRFTKILSLLRLLRL;LRIVRFTKILSLLRLLRLSRLIRYI;PPPASCEPR;VAAFPPAPRAGA;VDYIFLIV 8 7.5 1.0034 -0.83536 0 0 0 0 0 0 11.5381 0 10.3261 0 0 0 0 0 0 A0A8I3PSV3 A0A8I3PSV3_CANLF CDGSH iron-sulfur domain-containing protein 2 CISD2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422]; regulation of autophagy [GO:0010506] endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" EWLRLLPFLGVLALLGYL 1 13.3 0.97335 0.048313 0 0 0 0 0 0 0 3.68818 0 0 0 0 3.62234 8.44104 0 A0A8I3PSW1 A0A8I3PSW1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457] cytoplasm [GO:0005737]; prefoldin complex [GO:0016272] protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] TENNIVKEELALLDGSN 1 16.5 0.95411 0.050683 0 0 0 0 7.0881 0 0 0 0 0 0 0 0 0 0 A0A8I3PSW2 A0A8I3PSW2_CANLF Uncharacterized protein DDX11 Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] nucleus [GO:0005634] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]" DLVDRLKEE;GVDEDEDDPEEEH;LVENLCMK;MLAAGTGAK;TVTGALLLS 5 5.6 1.0007 -2.7459 0 0 0 0 0 0 0 0 0 0 0 0 0 6.61347 11.2706 A0A8I3PSX2 A0A8I3PSX2_CANLF BPI fold containing family A member 3 BPIFA3 Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] DISPKMKHFLH;VGWLIGSMSLQHQ 2 10.1 0.9841 -0.25688 0 0 0 0 0 0 0 0 0 0 0 7.99577 0 0 0 A0A8I3PSX9 A0A8I3PSX9_CANLF 3-hydroxyisobutyryl-CoA hydrolase (HIB-CoA hydrolase) (HIBYL-CoA-H) (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) HIBCH Canis lupus familiaris (Dog) (Canis familiaris) valine catabolic process [GO:0006574] mitochondrion [GO:0005739] 3-hydroxyisobutyryl-CoA hydrolase activity [GO:0003860] AGEVLLERRGCAGVITLN;DIRVISEG;DIRVISEGG 3 8.1 0.33333 0.60654 0 12.5519 12.2014 11.2124 12.5437 0 11.5741 0 0 11.3597 0 0 0 0 0 A0A8I3PSZ4 A0A8I3PSZ4_CANLF DNA topoisomerase (EC 5.6.2.1) TOP3B Canis lupus familiaris (Dog) (Canis familiaris) DNA topological change [GO:0006265] "DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]" AELVLPTIR;DPAELFSQAPTEKKEA;VISPGFTEIMPWQSV 3 4.6 1.0024 -0.97048 0 8.45409 0 0 5.3111 0 0 0 0 0 0 0 0 0 0 A0A8I3PSZ5 A0A8I3PSZ5_CANLF Villin 1 VIL1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament binding [GO:0051015] EAMKMVPVPSSTF;FQQLFQKWTLPN 2 3.3 0.99235 -0.55235 0 0 0 0 0 0 8.0607 0 0 0 0 0 0 0 0 A0A8I3PSZ8 A0A8I3PSZ8_CANLF Uncharacterized protein GLRA4 Canis lupus familiaris (Dog) (Canis familiaris) response to amino acid [GO:0043200] cell projection [GO:0042995]; chloride channel complex [GO:0034707]; glycinergic synapse [GO:0098690]; postsynaptic specialization membrane [GO:0099634] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824] DIQTCTMQLESFGYTMNDLVFEW;KGPQPMSP;YSIRLTLIL 3 8.8 1.0023 -1.0178 0 0 5.58655 0 0 0 0 11.8551 11.9035 0 5.59577 0 0 4.9568 6.32898 A0A8I3PSZ9 A0A8I3PSZ9_CANLF Small integral membrane protein 29 SMIM29 Canis lupus familiaris (Dog) (Canis familiaris) DLSSGAAW;LFHVPPSTAQR;YQHKRMPLL 3 10.7 1.0021 -1.8731 9.2465 0 0 7.22872 0 0 0 8.89561 0 0 9.65855 0 9.55419 0 0 A0A8I3PT05 A0A8I3PT05_CANLF Transmembrane and coiled-coil domain family 1 TMCC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; endosome fission [GO:0140285]; endosome membrane tubulation [GO:0097750]; membrane fission [GO:0090148] cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791] identical protein binding [GO:0042802] AVGASSSK;DEATAERIERLEVS;ERIERLEVSSLAQTSSAV;LENINVIGQGLKHLFQHQRRRSSV;MQSGRPRSSSTTDA;QEERYRCERL 6 12.2 1.0023 -0.95817 0 0 10.2492 7.63641 0 0 9.96939 8.64724 0 0 0 0 0 7.85891 0 A0A8I3PT07 A0A8I3PT07_CANLF Major facilitator superfamily domain containing 8 MFSD8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] GVLNIILILIL;GVLNIILILILLREHH;GVTWDTIKLQ;GVTWDTIKLQIN;ILILILLREHHVD;VEALIIFMGIKLLSKK 6 9.6 0.99335 -0.023133 0 0 0 0 4.86953 14.4315 0 0 4.96412 0 0 0 7.17313 0 0 A0A8I3PT10 A0A8I3PT10_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908] cytosol [GO:0005829]; nucleus [GO:0005634] fatty acid binding [GO:0005504] ALRKIVLLLKPD 1 11.8 0.95278 0.05044 0 0 0 0 0 0 5.53335 0 0 0 0 0 0 0 0 A0A8I3PT17 A0A8I3PT17_CANLF "Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (Nitric oxide synthase, brain) (Peptidyl-cysteine S-nitrosylase NOS1)" NOS1 Canis lupus familiaris (Dog) (Canis familiaris) multicellular organismal response to stress [GO:0033555]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; vasodilation [GO:0042311] dendritic spine [GO:0043197]; nucleoplasm [GO:0005654]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529] calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517] AAVRDSQQRSYKVR;AFGHAVDTLLEEL;ALMERLEDAPPVNQL;EDAPPVNQLVKVELLE;FSGWYMGTEI;LVLEVPIRHPKFEWFK;VEVLEEFPSIQ;VHLTVAIVSYRTGDGE;VLEVPIRHP;VLSLLTSGNKGING 10 7.9 0.9847 -0.25494 0 0 0 10.1261 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PT28 A0A8I3PT28_CANLF "DEP domain containing 5, GATOR1 subcomplex subunit" DEPDC5 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508] GATOR1 complex [GO:1990130]; lysosomal membrane [GO:0005765] GTPase activator activity [GO:0005096] EAIQIHHQTRQNMAELQGSGQRD;EDFSLIESLKFWR 2 2.3 0.93028 0.1076 0 8.11484 0 0 0 0 0 0 8.52705 0 0 0 0 0 0 A0A8I3PT46 A0A8I3PT46_CANLF Potassium voltage-gated channel modifier subfamily S member 2 KCNS2 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] perinuclear region of cytoplasm [GO:0048471]; voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] DFLKFFKNALNLIDLMSIV;DNPGYSVLSRIFSVLSI;LELCDDYDDAQREFYFDRNPELFPY;MASLTNMSRSSPSE;NEFFIDSCCSYSYHGR;PEQEKWDEQSDQEST;VLHFYHTGKLH 7 24.5 0.98733 -0.32658 0 0 10.7547 9.59178 0 14.8698 11.2352 15.5944 0 12.7598 0 0 0 15.3268 7.03815 A0A8I3PT52 A0A8I3PT52_CANLF G protein-coupled receptor 82 GPR82 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] VKRHLLVIQVLLVVCFLPYS;YFLKGFQWEYRSAQ 2 10.1 0.91715 0.10931 4.76346 0 0 0 0 0 0 0 0 0 0 0 0 0 9.6768 A0A8I3PT55 A0A8I3PT55_CANLF Vesicle-associated membrane protein 3 (Synaptobrevin-3) VAMP3 Canis lupus familiaris (Dog) (Canis familiaris) SNARE complex assembly [GO:0035493] early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synapse [GO:0045202] SNAP receptor activity [GO:0005484]; syntaxin-1 binding [GO:0017075] IGIVVVVIIIIIIIV;VVVIIIIIIIV 2 14.4 0.9379 0.089365 0 6.87578 0 0 0 0 0 0 2.96285 0 0 0 0 0 0 A0A8I3PT56 A0A8I3PT56_CANLF Leucine rich repeat containing 23 LRRC23 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] EAEVEHDSELE;LVQIAHLERLDKDFYE;SEEWMPTPLTE 3 11.1 1.0018 -0.67082 0 0 0 0 0 0 12.4981 0 10.0066 0 0 0 0 11.7279 0 A0A8I3PT58 A0A8I3PT58_CANLF Phosphodiesterase (EC 3.1.4.-) Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" EAAGWLCRHL;PLWESRDRYEELKQ;PSAAACGA;VRPMEVAEPWVDCLL 4 9 1.0019 -1.4179 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2366 A0A8I3PT60 A0A8I3PT60_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) DDR2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of neuron projection development [GO:0010976] membrane [GO:0016020]; receptor complex [GO:0043235] ATP binding [GO:0005524]; collagen binding [GO:0005518]; protein tyrosine kinase collagen receptor activity [GO:0038062] ILIGCLVAIIFILLAIIVIIL;LDGNSNPYDIFLKDL;LVAIIFILLAIIVIILWRQ;LVGTQGRHAGGHGIEFAPMYKIN 4 7.3 0.99436 -0.12259 0 0 0 0 0 0 0 0 11.3735 0 6.5905 0 0 0 0 A0A8I3PT61 A0A8I3PT61_CANLF F-box protein 3 FBXO3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DDDDDDSADMDESDEDDEEER;DDDDDSADMDESDEDDEEE;DDDSADMDESDEDDEE;DEYEEMEEEEEEEEEDDDDDD;EDDDDDDSADMDESDE;EDDDDDDSADMDESDEDDEEER;EEDDDDDDSADMDESDE;EEEEDDDDDDSADMD;EEEEDDDDDDSADMDESDED;EEEEEDDDD;EEEEEDDDDDDSADMDESD;EEEEEDDDDDDSADMDESDED;EEEEEEDDDDD;EEEEEEEDDDDDDSADMDESDED;EEEEEEEEDDDDDDS;EEEEEEEEDDDDDDSADMDESD;EMGPDEYEEMEEEEEEEEEDDDD;LEMGPDEYEEMEEEEEEEEEDDDDD;YVNNVVSGG 19 10.6 0.68231 0.28999 4.82365 10.6554 10.2969 10.1888 6.12485 6.50913 6.89215 7.95396 0 10.8688 5.6334 10.3242 7.99379 7.23026 7.78392 A0A8I3PT68 A0A8I3PT68_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] AGNCCSCYAGSC;AGNCCSCYAGSCCAGSCCAR;AGSCCVWSCCAGNCCERSCC;AQSCCVWSCCARSCCAWSCCSGSCC;AWSCCAWSCCAGNCCSC;AWSCCSGSCCAESCCA;CAGNCCSCYAGSCCAGSCCA;CAGSCCARSCCAWSCC;CAGSCCGRGCWSCCAGSCC;CARSCCGWSCCA;CAWSCCAWSCCAGNCCSCYAG;CAWSCCSGSCCAESCC;CCAGNCCSCYAGSC;CCAGNCCSCYAGSCCA;CCAGSCCARSCCAWSCCAG;CCAGSCCARSCCAWSCCAGSCCG;CCAGSCCARSCCAWSCCAGSCCGR;CCAGSCCGRGCWSCCAGSC;CCAGSCCVWSCCAGN;CCAGSCCVWSCCAGNCCERSCCV;CCARSCCAWSCCAGSCCGRGCWSCC;CCAWSCCAGN;CCAWSCCAGNCCSCYAGSCC;CCAWSCCAGNCCSCYAGSCCAG;CCAWSCCAGSCC;CCAWSCCAWSCCAGNCC;CCAWSCCAWSCCAGNCCSCYAGSC;CCAWSCCSGSC;CCAWSCCSGSCCAESCC;CCGWSCCAGSCCAG;CCSCYAGS;CCSCYAGSCCAGSCCA;CCSGSCCAESCC;CCSGSCCAESCCAGP;CCVWSCCAGNCCE;CCVWSCCAGNCCERSCCV;CGRGCWSCCAGSCCVWSCCAGNCC;CGWSCCAGSCCAG;CYAGSCCAGSCCARSCCAWSCCA;GCWSCCAGSCCVWSCCAGNCC;GNCCSCYAGSCCAGSCCARSCC;GTYCAQSCCVWSCCARSCCAW;GTYCERSCCARSCCGWSCCAGSCC;NCCSCYAGSCCAGSC;NCCSCYAGSCCAGSCCARSCC;RGCWSCCAGSCCVWSCCAGNCC;RSCCARSCCAWSCCAWSCC;SCCAESCC;SCCAGNCCSCYAGSC;SCCAGNCCSCYAGSCCAGS;SCCAGNCCSCYAGSCCAGSCC;SCCAGNCCSCYAGSCCAGSCCA;SCCAGSCCA;SCCAGSCCARSCCAWSCCAGSCC;SCCAGSCCGRGCWSCCAGS;SCCAWSCCAGNCCSC;SCCAWSCCAGNCCSCYAG;SCCAWSCCAGNCCSCYAGSCC;SCCAWSCCAGNCCSCYAGSCCAGS;SCCAWSCCAWSCCAGNCCS;SCCAWSCCSGSCCAESCC;SCCGRGCWSCCAGSCCVWSCC;SCCVWSCCARSCCAWSCCSGSCC;SGSCCAESCCAG;TYCAQSCCVWSCCARSCC;VGTYCERSCCARSCCGWSCCAGSC;VWSCCAGNCCERSCCVGTYC;WSCCAGNCCSCYAGSCCAGS;WSCCAGNCCSCYAGSCCAGSC;WSCCAGSCCARSCC;WSCCAWSCCAGNCCSCYAGSCC;WSCCAWSCCAGSCCARSCCAWSC;WSCCSGSCCAE;WSCCSGSCCAESCC;WSCCSGSCCAESCCA;YCERSCCARSCCGWSCCAGSCC 76 87.2 1.0028 -2.51 7.98885 8.96087 9.94918 8.22598 7.91833 9.173 6.68566 10.8456 7.9367 8.6786 7.96463 9.5386 9.144 12.4466 10.5195 A0A8I3PT73 A0A8I3PT73_CANLF Mannose-P-dolichol utilization defect 1 protein MPDU1 Canis lupus familiaris (Dog) (Canis familiaris) dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312] membrane [GO:0016020] DLLHVPCL;VTFLACYALV 2 7.3 1.0024 -0.76887 0 0 0 0 0 9.06302 0 0 0 0 0 0 0 0 0 A0A8I3PT76 A0A8I3PT76_CANLF Latexin LXN Canis lupus familiaris (Dog) (Canis familiaris) detection of temperature stimulus involved in sensory perception of pain [GO:0050965] metalloendopeptidase inhibitor activity [GO:0008191] VIWQNSTENTWY 1 5.4 0.9832 -0.25665 0 0 0 0 0 0 0 0 0 0 0 0 7.77755 7.44236 0 A0A8I3PT84 A0A8I3PT84_CANLF "G protein-activated inward rectifier potassium channel 1 (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)" KCNJ3 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] parallel fiber to Purkinje cell synapse [GO:0098688]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] G-protein activated inward rectifier potassium channel activity [GO:0015467] EGEFLPLD 1 1.6 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0688 A0A8I3PT94 A0A8I3PT94_CANLF XK-related protein XK Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] protein-macromolecule adaptor activity [GO:0030674] LILQLLIGYCTAILFMLVFYQ;LQLYISTLQ;LSSTYRSGGD 3 9 0.51724 0.4582 9.38444 8.83791 0 0 0 0 0 0 0 0 0 0 11.3854 0 0 A0A8I3PT95 A0A8I3PT95_CANLF peptidylprolyl isomerase (EC 5.2.1.8) PPIG Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] EESQSRNKEKYRNQESKSSHRK;RKIKGRGPRRYRTPSRSRSRDRFRR;SSSSSSDSDSSSDSQSSSD 3 8.9 0.88471 0.13185 6.03861 0 0 0 0 0 0 5.55655 0 0 0 0 7.11624 0 0 A0A8I3PTA0 A0A8I3PTA0_CANLF Family with sequence similarity 133 member A FAM133A Canis lupus familiaris (Dog) (Canis familiaris) EKATEKAKKKKKRKKKQHKK;ENKKKGSKALAEFEEKMNENWKKE;KAKKKKKRK;KAKKKKKRKKKQHKKHSKKKK;KKKKKKKK;KKKKKRKKKQ;KKRGKKKKKKKK;LSKKRKKT;RSSKKRGKKKKKKKK;TEKAKKKKKRKKKQHKK 10 29.2 1.0029 -2.5537 6.59107 1.82574 0 2.30658 4.95089 0 7.80678 2.33837 0 4.301 3.698 0 11.7239 0 8.50811 A0A8I3PTA9 A0A8I3PTA9_CANLF Hes family bHLH transcription factor 3 HES3 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] LWPVPGGVEFPSGFRS 1 9.1 0.95998 0.049233 0 0 0 0 0 0 9.10392 0 0 0 0 0 0 0 0 A0A8I3PTC3 A0A8I3PTC3_CANLF Calmodulin binding transcription activator 1 CAMTA1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255]; regulation of primary metabolic process [GO:0080090] DNA binding [GO:0003677] GGGLSPSTTLEQM;HRVKELRKAKE;IGQLKPMFHGIKWTCSN;LSPDASQGLVLAV;MQFQANFQA;NGGSQAQC;PTTGPNHHLLSPDAS;SPVSEIAFEKPSLPS;VEQLVQQIL 9 7.2 1.0024 -2.5814 0 11.6695 0 0 8.8219 7.38111 0 0 2.23781 10.7023 8.13909 0 0 8.89184 0 A0A8I3PTD3 A0A8I3PTD3_CANLF "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase)" BPNT2 Canis lupus familiaris (Dog) (Canis familiaris) chondrocyte development [GO:0002063]; chondroitin sulfate metabolic process [GO:0030204]; embryonic digit morphogenesis [GO:0042733]; endochondral ossification [GO:0001958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; post-embryonic development [GO:0009791] cytosol [GO:0005829]; nuclear body [GO:0016604]; trans-Golgi network membrane [GO:0032588] "3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]" KPVLGVIH;SPLGVAVF;TEEHVDAADQEVILWDHKIP 3 10 1.0018 -1.3184 12.4666 12.4938 0 0 0 0 8.84053 0 0 0 0 0 13.1097 0 6.42425 A0A8I3PTD7 A0A8I3PTD7_CANLF 40S ribosomal protein S17 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EERERRDNYVP;SSYVTHLM 2 15.1 0.98834 -0.47509 0 0 0 0 0 0 0 0 11.9902 0 0 0 0 0 0 A0A8I3PTE4 A0A8I3PTE4_CANLF Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) GABARAPL1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; cellular response to nitrogen starvation [GO:0006995] autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794] GABA receptor binding [GO:0050811]; ubiquitin protein ligase binding [GO:0031625] LDKRKYLVPS;TSATMGQLYEVSVLV 2 17.6 1.0041 -0.82672 8.3716 0 0 0 0 0 0 0 0 0 0 0 9.21169 9.96275 0 A0A8I3PTE5 A0A8I3PTE5_CANLF BTG anti-proliferation factor 3 BTG3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930] cytoplasm [GO:0005737]; nucleus [GO:0005634] LKACENSC;PSPVYQISELIF;VTSDYHSGSSSSDE 3 13.5 0.99073 -0.51558 0 0 0 0 0 10.8022 0 10.2498 0 9.74425 0 0 0 0 0 A0A8I3PTF5 A0A8I3PTF5_CANLF Trimethylguanosine synthase TGS1 Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine cap hypermethylation [GO:0036261] methyltransferase activity [GO:0008168] DTKEEWEQHYSQLYWYYLEQFQYWE;ESKKKKKKKKNK;ESKKKKKKKKNKSKKV;ESKKKKKKKKNKSKKVIG;IDENPDSDFDDN;KKKKKHQKKYLDEI;KKKKKKKK;KKKKKKKN;KKKKKKKNKSKKV;KKKKKKKNKSKKVI;KKKKKKKNKSKKVIGLPPEIA;KKKKNKSKKVIGLPPEIAAVP;KKSKTLTKVEKFLKWI;KVKIKKKKKKHQKKYLDEI;NTRNKVKIKKKKKKHQKK;RNKVKIKKKKKKHQKK;RNKVKIKKKKKKHQKKYLDEI;SKKKKKKKKNKSKKV;YYLEQFQYWEAQGWTFDVSQTCET 19 14.8 0.10811 0.84793 0 9.08638 6.66633 6.16854 6.70404 6.07256 6.93923 3.59765 6.0998 0 4.58676 0 8.26754 5.10693 0 A0A8I3PTF7 A0A8I3PTF7_CANLF Forkhead box M1 FOXM1 Canis lupus familiaris (Dog) (Canis familiaris) G2/M transition of mitotic cell cycle [GO:0000086] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] LDEPEPELLFSQGP;PLILKRRRLPLPV;RRPLILKRRRLPLPV 3 3.9 0.86252 0.17455 0 0 6.63156 0 0 0 0 0 0 5.80413 9.59707 9.95469 0 0 0 A0A8I3PTF9 A0A8I3PTF9_CANLF Uncharacterized protein KRT81 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] GVGSCASSC;LEPLFEGYIETL;VGSCASSC 3 4.1 0.9934 -0.17045 0 0 0 0 0 0 15.214 0 15.3901 0 0 0 0 0 0 A0A8I3PTG0 A0A8I3PTG0_CANLF Tripartite motif containing 77 TRIM77 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EDIFLLLCI;HYREKLLMQMRSIWKNKQ;LQCSSDHQ;TGMSERLNN 4 9.8 1.0022 -1.8792 0 0 0 0 4.81757 0 0 10.1353 0 0 0 0 0 0 10.7334 A0A8I3PTH3 A0A8I3PTH3_CANLF NK2 homeobox 4 NKX2-4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAGDFGGGV;LSPIEETYKK;SPIEETYKKFGGAMDG 3 7.3 1.0011 -0.92187 0 0 0 0 0 0 0 10.3827 0 0 0 11.0966 0 0 11.9353 A0A8I3PTH5 A0A8I3PTH5_CANLF Signal transducer and activator of transcription STAT4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ENQDWEAASNNETMATILLQNLLI;EQLGRVSKE;EQLGRVSKEKNLLLIHNLKRIRKVL;IQFTVKLRLLIKLPELNYQVKV;NLLLIHNLKRIRKVLQG;PMVLKTLIQFTVKLRLLIKL;QRPMVLKTLIQFTVKLRLLIKLP;QVDQFYDDNFP;SLPVVMISN;VDQFYDDN 10 14.9 1.0039 -0.80939 9.4957 9.00728 0 4.53269 0 9.82416 9.03906 6.25884 0 6.37591 5.89719 0 5.41525 7.08119 0 A0A8I3PTI3 A0A8I3PTI3_CANLF RING-type domain-containing protein RNF220 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] KMKRRKQDEGQVCPLCNRPLA 1 6.3 0.97797 0.047716 0 7.03144 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PTI8 A0A8I3PTI8_CANLF Gliomedin GLDN Canis lupus familiaris (Dog) (Canis familiaris) clustering of voltage-gated sodium channels [GO:0045162]; microvillus organization [GO:0032528] cell surface [GO:0009986]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] protein binding involved in heterotypic cell-cell adhesion [GO:0086080] GDKGDVSNDVLLTGAKGDQGP 1 3.8 0.95042 0.049568 0 0 0 0 0 0 0 0 0 0 0 0 0 7.92374 0 A0A8I3PTJ1 A0A8I3PTJ1_CANLF Rho guanine nucleotide exchange factor 3 ARHGEF3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DYERMEQTDSSC;EQMDQSDS;LREILRHTPN;PRSRLVKYPLLLREILR;QCVFRGMEENKERPRR;QMDQSDSESDCS;SETFDVCVNQMLPSKEI;SEVSLDYERMEQTDSSCGNS 8 15.6 1.0031 -1.7255 0 0 0 0 6.41572 0 3.09746 11.403 0 0 0 0 8.97304 0 9.10617 A0A8I3PTJ2 A0A8I3PTJ2_CANLF N-terminal EF-hand calcium binding protein 3 NECAB3 Canis lupus familiaris (Dog) (Canis familiaris) protein metabolic process [GO:0019538]; regulation of amyloid precursor protein biosynthetic process [GO:0042984] endoplasmic reticulum membrane [GO:0005789]; Golgi cis cisterna [GO:0000137] calcium ion binding [GO:0005509] EGASDTLEAQAQGPR;KLEYERASKVDQFVTRFLLRETV;SFTLYEFWRDEASWRRHQH;WPPELAPGRSLWSRS 4 14.5 0.99233 -0.14217 0 0 0 0 0 5.33803 0 0 0 0 0 8.25304 0 7.41481 0 A0A8I3PTJ5 A0A8I3PTJ5_CANLF Cysteinyl leukotriene receptor 2 CYSLTR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] leukotriene receptor activity [GO:0004974] FLPYHILRTLHLMEWK;VSHKKALITVIIALIIFLL 2 10.1 0.93328 0.098643 8.68029 0 0 0 0 0 0 6.43219 0 0 0 0 0 0 0 A0A8I3PTJ6 A0A8I3PTJ6_CANLF Uncharacterized protein BMP15 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] FIEKDSSLLRRARQA;GSEILELQWHGTSSLDT;IQNLVNELVDQSVP 3 11.7 0.99216 -0.14154 0 0 10.5 0 0 0 10.6671 0 0 0 0 0 0 0 0 A0A8I3PTK2 A0A8I3PTK2_CANLF Caspase recruitment domain family member 8 LOC102153616 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] LVSSSRAPARPGRQ;STVDHSTT 2 3.4 0.99557 -0.19031 0 0 0 0 12.3044 0 13.2942 0 0 0 0 0 0 0 0 A0A8I3PTK4 A0A8I3PTK4_CANLF Chromosome 21 open reading frame 91 C31H21orf91 Canis lupus familiaris (Dog) (Canis familiaris) IDLNDDNICSVCKL;QKKEELISNPEANV 2 12.7 0.99264 -0.17786 0 0 0 0 0 0 0 0 0 0 7.11437 0 0 0 0 A0A8I3PTK6 A0A8I3PTK6_CANLF Forkhead box D2 FOXD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific double-stranded DNA binding [GO:1990837]" AAAAAPCQLSV;ADAAEDEEESGGCSDGEP;AGQRPSFSID;DAAEDEEESGGC;DAAEDEEESGGCSDG;EADAAEDEEESGGC;EKFPAWQNSIRHNLS;GGGGGGGA;GGGGGGGE;GGGGGGGG;SCCCEIMSSESSPAALSEADAD;VGGGGGGG;VGGGGGGGG 13 19.5 0.9892 -0.26511 0 0 10.895 5.03435 0 0 6.2093 0 10.3492 6.06044 0 0 0 6.89033 0 A0A8I3PTL5 A0A8I3PTL5_CANLF Cyclin-T1 CCNT1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation by host of viral transcription [GO:0043923]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968] cytosol [GO:0005829]; P-TEFb complex [GO:0070691] 7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; DNA-binding transcription factor binding [GO:0140297]; molecular condensate scaffold activity [GO:0140693]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription cis-regulatory region binding [GO:0000976] DELTHEFL;PRLPPLPSEPPPPLPP;QQDGSNAFISQ;TLELLDELTHEFLQILE 4 6.1 0.9895 -0.50926 0 0 0 0 0 0 12.0448 0 0 0 0 0 0 0 0 A0A8I3PTL9 A0A8I3PTL9_CANLF Sad1 and UNC84 domain containing 5 SUN5 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nuclear inner membrane [GO:0005637] FQFQPENIIQMFQLQ 1 4.1 0.93728 0.073479 0 0 0 0 0 0 10.0444 0 0 0 0 0 0 0 0 A0A8I3PTN2 A0A8I3PTN2_CANLF Poly(rC) binding protein 1 PCBP1 LOC491817 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] QDRCGDAAGYPHAT 1 3.9 0.98877 -0.26245 0 0 8.72833 0 0 0 0 0 0 0 0 0 0 0 8.50494 A0A8I3PTN6 A0A8I3PTN6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] AEDTAMYYC;EVQLVEYGGELVKPGGSLR;SVLAWVFLIAILKGV;VRQAPGKGLQ 4 35.1 0.95678 0.050867 0 0 0 6.32515 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PTN7 A0A8I3PTN7_CANLF Suppressor of fused homolog SUFU Canis lupus familiaris (Dog) (Canis familiaris) aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; heart looping [GO:0001947]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural tube closure [GO:0001843]; skin development [GO:0043588]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; ventricular septum development [GO:0003281] cilium [GO:0005929]; GLI-SUFU complex [GO:1990788]; nucleoplasm [GO:0005654] beta-catenin binding [GO:0008013]; protein kinase binding [GO:0019901] EDPQMQPVQTPFGVVT;GRHFTYKSI;MRRGETIFE 3 7 1.0036 -1.0636 12.0416 0 0 0 0 0 0 0 0 0 11.075 0 0 11.9153 11.2478 A0A8I3PTN8 A0A8I3PTN8_CANLF Hydroxyacylglutathione hydrolase like HAGHL Canis lupus familiaris (Dog) (Canis familiaris) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] AEEPVRKFTGKAAPAEVLEA;PVLEDNYMY;STALQMYES;YFLWEEECPDPPAVFSGDA 4 20.1 0.9917 -0.5443 9.63731 0 9.2734 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PTP5 A0A8I3PTP5_CANLF "Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase)" ECHS1 Canis lupus familiaris (Dog) (Canis familiaris) hydro-lyase activity [GO:0016836] ATEDRKEGMTAF;PGTSPLLHP;TDGGGAGA 3 4.5 0.98356 -0.24785 0 0 0 0 0 0 0 0 8.7488 0 0 0 0 0 0 A0A8I3PTQ0 A0A8I3PTQ0_CANLF WT1 transcription factor WT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nuclear speck [GO:0016607] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" SLGGGGGCALPV;TVHFSGQFTGT 2 4.5 0.99242 -0.55244 0 0 0 0 0 0 0 0 0 0 0 0 7.77294 0 0 A0A8I3PTQ5 A0A8I3PTQ5_CANLF Proline rich and Gla domain 3 PRRG3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] calcium ion binding [GO:0005509] KRFPRANEFL;TAPQESSSEEASVSYSD 2 11.7 0.99577 -0.56523 0 0 0 0 0 0 0 0 0 0 8.42063 0 0 0 8.19343 A0A8I3PTQ7 A0A8I3PTQ7_CANLF Myosin phosphatase Rho interacting protein MPRIP Canis lupus familiaris (Dog) (Canis familiaris) CWYWGSMQ;EAPTAPLPDTSA;EQSQKEASDLLEQ;YWGSMQLQEVQPTTL 4 4.4 1.003 -1.3311 0 0 0 0 0 0 0 0 9.84599 0 0 4.53431 0 0 0 A0A8I3PTQ9 A0A8I3PTQ9_CANLF CXXC-type zinc finger protein 4 CXXC4 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] AAGGGGGG;GGGGGGGG;GVCSSCRNRKTGHQICKFRKCE;LPAGGGGGG 4 15.3 0.9749 0.046969 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.72457 A0A8I3PTR6 A0A8I3PTR6_CANLF RUNX family transcription factor 1 RUNX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FNDLRFVGRSGRG;VDASTSRR 2 8.4 0.98814 -0.26496 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.9065 A0A8I3PTR8 A0A8I3PTR8_CANLF Tubulin/FtsZ GTPase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525] PGTLDSVRSGAFGHLFRPD 1 15.6 0.95321 0.049843 0 0 0 0 0 7.55075 0 0 0 0 0 0 0 0 0 A0A8I3PTR9 A0A8I3PTR9_CANLF Ankyrin repeat and SOCS box containing 18 ASB18 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GLARLLLRHGADPGALDYGGASP;HGADPDLLSAEG;PESLQNYL;VTGDLSRLEQ 4 12.1 1.0018 -0.9116 0 6.80452 0 0 0 9.33076 0 7.82369 7.73125 0 0 10.6314 0 0 0 A0A8I3PTT5 A0A8I3PTT5_CANLF C1GALT1 specific chaperone 1 C1GALT1C1 Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; platelet morphogenesis [GO:0036344]; protein O-linked glycosylation [GO:0006493] membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263] GLTPNQMHVMMYGVYRLRAFGHIFH;VEGCCSDMAVTFNGLT;WLMMRKAYKYAFDKYRDQYNWFFL 3 19.5 0.99204 -0.20708 0 0 0 0 6.47513 4.73221 7.20477 0 0 0 0 0 0 0 0 A0A8I3PTT6 A0A8I3PTT6_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEHHLRDY;VAVGMAITDLVM 2 8.7 0.94239 0.05044 0 10.0532 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PTT9 A0A8I3PTT9_CANLF Tripartite motif containing 8 TRIM8 Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein localization to nucleus [GO:1900182]; protein K63-linked ubiquitination [GO:0070534]; stem cell population maintenance [GO:0019827]; suppression of viral release by host [GO:0044790] cytosol [GO:0005829]; membrane [GO:0016020]; PML body [GO:0016605] metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] QTLRDELTPR;RCEAPCCQSHVQ 2 3.8 1.0026 -0.8951 0 0 0 0 0 10.1799 0 0 0 0 3.77863 0 3.15814 0 0 A0A8I3PTU0 A0A8I3PTU0_CANLF Uncharacterized protein AMER1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEQDMDSMTDS;ALPDDEEEEEEEDEVELEEEEED;AMKLFGGK;AYAREAQVREAHAQEAQVREVQ;DQQESAPNSDEGYYDSTTPG;DSYSGDALYEFYE;EEDEVELEEEEEDVKEEE;EPEEEEAEKEGNA;EPQQPQPIH;LPRVQPEPQ;MLLPIDEPN;PNSDEGYYDSTTP;QESAPNSDEGYYDSTTPGFEDDS;QQEDSNEEEEE;SPLSLYTEPP 15 14.6 1.0018 -1.8032 0 9.01488 10.0174 9.32773 0 5.33099 0 0 0 0 7.96382 12.9104 0 8.98581 8.21898 A0A8I3PTU2 A0A8I3PTU2_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP9A Canis lupus familiaris (Dog) (Canis familiaris) "endocytosis [GO:0006897]; phospholipid translocation [GO:0045332]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endosome [GO:0005768]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AALSQFVIHRS;EAEKQYEDSC;EAEKQYEDSCRVY;EGLRVLVVAKK;GDSLEVCLKYYEYE;KYLRRRFSPPSYS;LAADFSITQFKH 7 8.1 1.0031 -1.9394 0 4.47781 0 0 0 0 0 9.82647 0 0 8.29838 8.52572 7.59991 0 0 A0A8I3PTU8 A0A8I3PTU8_CANLF von Willebrand factor A domain-containing protein 1 VWA1 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to pain [GO:0048266]; extracellular matrix organization [GO:0030198]; protein homooligomerization [GO:0051260] basement membrane [GO:0005604]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]; membrane [GO:0016020] microfibril binding [GO:0050436]; protein homodimerization activity [GO:0042803] LVWVTDGGSSDPV;VLVWVTDGG 2 3.4 0.94037 0.064145 0 0 9.69446 0 12.5437 0 0 0 0 0 0 0 0 0 0 A0A8I3PTV2 A0A8I3PTV2_CANLF Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] QAMSVFIVSFYRN 1 7.3 0.93972 0.059797 0 0 0 0 0 0 0 8.42454 0 0 0 0 0 0 0 A0A8I3PTW2 A0A8I3PTW2_CANLF Large ribosomal subunit protein uL23 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] PPKAKAKAKALKAKKAVLKGVHS 1 14.8 0.97865 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 6.52286 0 A0A8I3PTW3 A0A8I3PTW3_CANLF Myosin phosphatase Rho interacting protein MPRIP Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton [GO:0015629]; cytosol [GO:0005829] ASERAQRLMEEKLQA;DEMPTTLPQGTINMNQ;DREQQMEVLQK;EALPAPSSPP;EAPTAPLPDTSA;EHGLLRYALDEMPT;EQSQKEASDLLEQ;GEVLSHQKAAGSQEPFF;GIEDNVQASWDLSP;LQCYKESWQSRGA;PATSDSDT;QKDFENLKATCERG 12 6.3 1.0031 -2.1578 13.0262 0 0 0 9.08164 8.45426 0 0 7.39643 10.014 9.33932 0 0 0 0 A0A8I3PTX5 A0A8I3PTX5_CANLF Signal peptide peptidase like 2C SPPL2C Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; intracellular calcium ion homeostasis [GO:0006874]; membrane protein intracellular domain proteolysis [GO:0031293] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; lumenal side of endoplasmic reticulum membrane [GO:0098553] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; molecular adaptor activity [GO:0060090]; protein homodimerization activity [GO:0042803]" AHDTGLPWMG;EVASGPVD;MRGNCSLH;QELTLFWTGQARAKTPAQ;STLLTSLA 5 7.9 1.0039 -1.0601 0 12.4723 10.195 0 0 11.2003 12.5472 12.5427 3.29346 12.1361 11.9659 12.3149 0 0 0 A0A8I3PTX8 A0A8I3PTX8_CANLF GATOR2 complex protein WDR24 WDR24 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; positive regulation of TORC1 signaling [GO:1904263]; protein K6-linked ubiquitination [GO:0085020]; regulation of autophagy [GO:0010506] cytosol [GO:0005829]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] FTAHNGPVFCCDWHPED;KQDQLFTEHKR;KRKLDPSEPFVGLASSALSVFE;PEHAHAEEPEYV 4 7.8 1.0025 -0.80018 0 0 0 0 9.11267 0 0 0 9.46037 0 0 0 0 0 0 A0A8I3PTY0 A0A8I3PTY0_CANLF HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) HBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] DDSGVFDTFKS;ESVSFGES;QNTSDISENTYGE;SSGTVSATSPNKC 4 8.8 1.003 -1.5229 3.34113 14.9968 0 0 0 10.4533 0 0 0 0 0 0 9.382 0 0 A0A8I3PTY1 A0A8I3PTY1_CANLF Structural maintenance of chromosomes protein SMC4 Canis lupus familiaris (Dog) (Canis familiaris) chromosome organization [GO:0051276] chromosome [GO:0005694]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GFSKSVNEARSKM;LDLEDVQVREK;LEKFTASIQRLSEQEEYLNIQ;LLEENVSVF;LLEENVSVFKTEY;LSVLIHNSD;NKMTKIQTPEN;PDGPSSDAEPEPPPGR;PSEEIDNRSLEEILN;SEKIITEMTTRNSALE;VIDSMLFVFG 11 11 1.0017 -1.8047 0 8.26435 0 9.19148 0 6.72165 0 0 11.7846 10.6944 7.71672 0 10.0979 0 7.67532 A0A8I3PTY8 A0A8I3PTY8_CANLF Dishevelled segment polarity protein 3 DVL3 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; intracellular signal transduction [GO:0035556]; planar cell polarity pathway involved in neural tube closure [GO:0090179] cytosol [GO:0005829] frizzled binding [GO:0005109] LMRRHKRRRRKQKVSRIERSSSFS;LVKLPLPA;LVSAEGSHPEAAP 3 6.3 1.0025 -1.0032 0 0 3.39383 0 0 0 7.59425 0 0 7.73464 0 0 0 0 0 A0A8I3PTZ4 A0A8I3PTZ4_CANLF Minichromosome maintenance 8 homologous recombination repair factor CRLS1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid biosynthetic process [GO:0008654] plasma membrane [GO:0005886] cardiolipin synthase (CMP-forming) [GO:0043337]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] SLAAPVFNYADSIYLQ;YRTLPTPRTLSKY 2 14.3 0.98703 -0.38357 0 10.6755 0 0 0 0 0 8.42429 0 0 0 0 0 0 0 A0A8I3PU01 A0A8I3PU01_CANLF Coiled-coil domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AIQNQGFYEARFTSQVQQFVNNQES;CVTSTHLKWNAIK;DIPLNLKEQ;EDIISEPWQ;EECSAPEAQ;ELPATVPESLDLS;ESEHLPQEKKDGENVV;FERKQNQPFFYACIPAD;GSNLKAKMQQMSQSKNVADTF;HSSMDVLQIKLPCVKKIL;HWDCDYSYTQ;IDTIELNFK;IGLKAKKSPLLLILKTKKL;IGLKAKKSPLLLILKTKKLQ;IPFQIEELSKNIPSQKAIPHR;IPMRLPVNPWRKEQ;KAKTDKTTTGSSHSVVK;KIRKKLSGAKRLLSPKSVIRKVKKS;KKRDTSNTIDMNIPSL;KMQQMSQSKNVAD;KYIGLKAKKSPLLLILKTKK;LDLHQSEG;LIFEEKSLHQIDLDLQYKY;LNRPKIIFPEKLRVKQPHSSTQD;LPSMEIASTE;LSLEGIDTIELNFKQKY;LVEEKEHPECIHQISP;LVNVSYSVETQDSIKGLESD;MDITVFDTIGGE;NRIKAESDVSWKMRFSH;QESLPSMEIASTEV;SGKKTYTKSFDG;TKTQKGLKYA;VIEQDISHRM;VKTTYVETTDTEL;VPKRKNRVLLIF 36 7.2 0.99687 -5.7779 10.9522 0 11.2806 11.4773 7.73877 9.58598 11.2003 11.7477 12.8429 9.17033 3.70454 10.3624 0 10.2944 10.454 A0A8I3PU04 A0A8I3PU04_CANLF Uncharacterized protein SGSM1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] GTPase activator activity [GO:0005096] ERHNTKHILK;ESTRNQIQGLQ;FPPAEELSHK;LENNMDFTDIIKFFN;MDEFMSLT;TADHFWTDPSAD;YDDVFSVWETIWAAKHV 7 7.8 1.0037 -2.0303 9.45964 0 0 0 9.76305 11.1649 0 0 0 0 11.6227 0 0 0 0 A0A8I3PU06 A0A8I3PU06_CANLF Nanos C2HC-type zinc finger 3 NANOS3 Canis lupus familiaris (Dog) (Canis familiaris) "apoptotic signaling pathway [GO:0097190]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of cell cycle [GO:0051726]; spermatogenesis [GO:0007283]" cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] AAACAGGW;VENLEGYSTR 2 8 1.0029 -1.7158 9.54965 0 0 0 0 0 0 0 0 0 0 8.30346 0 0 10.2623 A0A8I3PU21 A0A8I3PU21_CANLF PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) PICK1 Canis lupus familiaris (Dog) (Canis familiaris) dendritic spine maintenance [GO:0097062]; intracellular protein transport [GO:0006886]; monoamine transport [GO:0015844]; positive regulation of receptor internalization [GO:0002092]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588] actin binding [GO:0003779]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080] LDIVLKKVK;QDEFTDGEDEEDEDDEDTAT;SQDEFTDGEDEEDEDDEDTATGE 3 7.7 1.0013 -0.70976 0 0 0 4.0552 0 3.91025 4.56541 0 0 0 0 0 0 0 0 A0A8I3PU27 A0A8I3PU27_CANLF Sortilin related VPS10 domain containing receptor 1 SORCS1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APGACGGA;ASRDTAPSIIVASGNIGSELSDSDI;EPCVCTEADFDCDYGYERH;GAPRDGARPEPGTP;GVYFTLALENVQ;LGEPGEETLIM;LIDEKVESQLIGE;NAILQDTKTIA;RCPEPPSGPAPRWAPA;YSSAEFGRRWQLIQEG 10 12.3 0.93718 0.069299 0 0 0 0 0 0 0 0 0 0 5.93579 0 0 0 0 A0A8I3PU31 A0A8I3PU31_CANLF Fibrosin like 1 FBRSL1 Canis lupus familiaris (Dog) (Canis familiaris) DLEPACDR;PEHPGPPKPSLLG;QSRRSRAQRDRGRRREAARD 3 7.2 0.9499 0.059561 0 0 0 0 0 0 0 0 0 0 0 6.66917 0 0 0 A0A8I3PU33 A0A8I3PU33_CANLF DOP1 leucine zipper like protein B DOP1B Canis lupus familiaris (Dog) (Canis familiaris) Golgi to endosome transport [GO:0006895] cytosol [GO:0005829] EIYDRTDAL;ELLTYLCLSF;EQELLNDYRYRNYSSV;LRLSLVVGKEVFYAALWGSVLV;LSTLQTDT;PASLFVVG;PESELSNSYED;QENSAEDLHRW;RVLLLRISPQ;SYLDMEPT 10 5 0.9969 -4.1269 0 9.96342 7.54102 4.97554 0 0 8.48527 0 0 4.54207 0 10.4148 0 7.3156 9.28725 A0A8I3PU34 A0A8I3PU34_CANLF Trafficking protein particle complex subunit TRAPPC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008] FVSKMSPLDMKDGFLAF 1 11.7 0.98832 -0.224 0 0 0 0 0 0 0 0 0 9.45125 0 0 0 0 0 A0A8I3PU39 A0A8I3PU39_CANLF Neuropeptide S receptor 1 NPSR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] neuropeptide receptor activity [GO:0008188] TQRHEMQVL 1 2.9 0.9859 -0.23588 0 0 0 0 9.6635 0 0 0 0 0 0 0 0 0 0 A0A8I3PU51 A0A8I3PU51_CANLF G protein-coupled receptor 176 GPR176 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] CSVPYATLVVYQT;VIYINMGNFMVLW;VTDVADIYAMSTCT 3 8.5 1.0015 -0.64275 0 0 0 0 0 0 11.0904 0 0 12.909 12.6917 0 0 0 0 A0A8I3PU56 A0A8I3PU56_CANLF Chromosome 3 open reading frame 84 C20H3orf84 Canis lupus familiaris (Dog) (Canis familiaris) GPYCLLQGIGRRKDL 1 7.5 0.95268 0.053901 0 0 9.15722 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PU60 A0A8I3PU60_CANLF Cytochrome P450 2E1 (EC 1.14.13.n7) (EC 1.14.14.1) CYP2E1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743] aromatase activity [GO:0070330]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506] GVGSRPQVLLSATVKHLPR;LDNIAVTVADLFF;VLFDKQEFPDPEKFKPEHFLNENGK;YNIFPSYLHYL 4 14.6 0.99109 -0.2693 7.86555 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PU66 A0A8I3PU66_CANLF ethanolamine kinase (EC 2.7.1.82) CHKB Canis lupus familiaris (Dog) (Canis familiaris) ADWAEPWS;AERSLGPQLYGVFPE;LLEMYSLKDEMGNLRK;LVLESVMFAILAE;LVSNADEGAAGGQS;PGASRAGP;PPPGGAGA;RTSEPRQRAEPAP 8 14.6 0.99722 -3.5732 0 10.4893 0 0 0 7.84593 9.5805 12.0464 0 9.80058 0 0 0 8.46361 0 A0A8I3PU70 A0A8I3PU70_CANLF procollagen-proline 3-dioxygenase (EC 1.14.11.7) P3H3 Canis lupus familiaris (Dog) (Canis familiaris) collagen biosynthetic process [GO:0032964]; negative regulation of cell population proliferation [GO:0008285] catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" EEEEEEEEEEMP;LLLLLLLL;LLLLLLLLP;LLLLLLLLPPPGSPEPPGLAPLSP;LLLLLLLP;LRLLRLLLLLLLLPPPGSP;LRLLRLLLLLLLLPPPGSPEPP;MLRLLRLLLLLLLLPP;RLLLLLLL;RLLLLLLLL;RLLLLLLLLPPPGS;RLLRLLLLLLLLP;SGLLYLNDDFHGGDLFFTEPNAL 13 8.8 0.98874 0.029011 7.17103 0 6.09552 0 0 0 10.5994 0 0 0 0 0 0 10.7275 7.97825 A0A8I3PU76 A0A8I3PU76_CANLF ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) PFKM Canis lupus familiaris (Dog) (Canis familiaris) fructose 6-phosphate metabolic process [GO:0006002] cytoplasm [GO:0005737] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] ADWVFIPECPPDD;DDDWEEHLC;GLVGSIDNDFCGTDMTIGTDSA;LKLRPILKIL;LKLRPILKILAK;NWMSGKIKESYRRIFANTPDSGCVL;TFRSEWSDLLSDLQK;TTCDRIKQSAAGT 8 13.7 1.0036 -2.0452 0 3.42048 12.9859 6.96324 0 8.215 8.49237 0 3.48091 0 8.84361 0 9.84304 0 0 A0A8I3PU82 A0A8I3PU82_CANLF ERI1 exoribonuclease family member 3 ERI3 Canis lupus familiaris (Dog) (Canis familiaris) "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" 3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676] FGASMAAMVPF;VDGQPSLQ 2 4.1 1.0036 -1.0689 0 0 0 0 0 0 7.10811 8.36715 0 0 0 0 0 0 0 A0A8I3PU89 A0A8I3PU89_CANLF Arachidonate 15-lipoxygenase type B ALOX15B Canis lupus familiaris (Dog) (Canis familiaris) lipid oxidation [GO:0034440] cytoplasm [GO:0005737] "iron ion binding [GO:0005506]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" EYTLEHWQEDTFFASQ;KTWVRNAE;VGPLLLLRV 3 5.5 0.96081 0.049233 0 0 4.99684 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PU96 A0A8I3PU96_CANLF Calumenin CALU Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509] DGFIDLEEYIGDMYSHDGNADEPEW;GAEEAKTFDQ;IVSKIDGDKDGFVTVDE 3 16.5 0.98963 -0.52886 0 0 0 0 0 7.06641 0 0 0 0 7.45088 7.14078 0 0 0 A0A8I3PU98 A0A8I3PU98_CANLF 60S ribosomal protein L36a-like LOC610388 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] DSLYAQGKRRY;VLRFECVEPNCR 2 21.7 0.94174 0.085931 0 0 0 0 0 8.64793 0 0 0 0 0 0 0 11.2976 0 A0A8I3PUA0 A0A8I3PUA0_CANLF Cytochrome P450 (EC 1.14.14.1) LOC100688697 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" LLILLKHPEVE;NTLRLALLILLK 2 3.4 0.9825 -0.25145 0 0 0 0 0 0 0 0 0 0 3.91255 0 0 0 0 A0A8I3PUA3 A0A8I3PUA3_CANLF SIM bHLH transcription factor 2 SIM2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; lung development [GO:0030324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399] nuclear body [GO:0016604] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein heterodimerization activity [GO:0046982] HSNMFMFRASLDLKLIFL;HYANPLVPSSP;LTDIEYKELQ 3 5.8 0.98655 -0.38794 0 0 0 0 9.78493 0 0 0 9.63932 0 11.3951 0 0 0 0 A0A8I3PUA5 A0A8I3PUA5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] APGKGLQWVAYN;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLQ 26 31.6 0.98736 -0.23077 0 0 0 0 0 0 0 9.69462 0 0 0 0 0 0 0 A0A8I3PUB3 A0A8I3PUB3_CANLF FKBP prolyl isomerase 4 FKBP4 Canis lupus familiaris (Dog) (Canis familiaris) GVLKIRNLKLF 1 23.9 0.98177 0.035491 0 0 0 0 0 0 0 0 0 0 3.25805 0 0 6.4641 0 A0A8I3PUC6 A0A8I3PUC6_CANLF Putative homeodomain transcription factor 2 PHTF2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] EDLLHCAEC;IKLGLRNKPKKTAH;LILGLTPFVF;QDSESTRP;SYSVGAVFRDL;TRPESETEDVLWEDLLH 6 8.1 1.0029 -1.9037 0 4.54838 0 0 0 9.96217 0 3.98878 7.62337 0 4.18642 0 0 0 10.46 A0A8I3PUD5 A0A8I3PUD5_CANLF "phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)" PIK3CB Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-mediated signaling [GO:0048015] cytoplasm [GO:0005737]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005] EAGLDLRMLPYGCLATGDRSG;FKNGDDLRQDMLT;LYGGKLIVAV;PHFMLVEC;QCCEDAYL 5 6 1.0045 -1.0535 0 0 0 0 9.32629 0 0 0 0 0 7.43654 0 0 0 0 A0A8I3PUE9 A0A8I3PUE9_CANLF TIA1 cytotoxic granule associated RNA binding protein TIA1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AENAIQQMGG;PDKGYSFVRQTQSSAP 2 9.1 0.96276 0.049233 0 0 0 0 0 0 8.33967 0 0 0 0 0 0 0 0 A0A8I3PUF7 A0A8I3PUF7_CANLF Erythrocyte membrane protein band 4.1 like 1 EPB41L1 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] LVGASALVNGRAFLLPPL 1 2.2 0.97706 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.05028 0 0 A0A8I3PUG0 A0A8I3PUG0_CANLF Hexosyltransferase (EC 2.4.1.-) CSGALNACT2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] EDEEQEDEDGPL;FREEIETHL;IEAGLEVINNPDEDEEQED;LLLGLALLCSLVLFLYLLE;NNPDEDEEQEDEDGPL;QIAQLKQELQEMSEKMRSL;TRTHWLLLGL 7 20.2 0.98497 -0.25927 0 0 0 0 0 0 10.0489 0 0 0 0 0 0 0 0 A0A8I3PUH5 A0A8I3PUH5_CANLF "SPT20 homolog, SAGA complex component" SUPT20H Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] EAKCPVKMSHSSS;EDEENDSQMSPSHSST;IPSEVDVEKYA 3 5.4 0.9922 -0.17741 0 8.52074 0 9.79201 0 0 0 0 0 10.3645 5.77858 5.20077 10.5686 0 4.98258 A0A8I3PUI3 A0A8I3PUI3_CANLF "Ferredoxin-2, mitochondrial (Ferredoxin-1-like protein)" FDX2 Canis lupus familiaris (Dog) (Canis familiaris) P450-containing electron transport chain [GO:0140647] mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]" EREEDMLDMAP 1 5.9 0.99176 -0.034699 0 0 0 8.74937 0 0 0 0 0 0 0 9.4661 9.29664 9.27991 0 A0A8I3PUJ4 A0A8I3PUJ4_CANLF KIAA1549 like KIAA1549L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATRLPPVP;AVETTSRKLA;IAEPLEYP;IDEVRQQMHMLL;KNDFKPDTMM;QAPAKNTQDLIGTPHLGFSGP;QQKVTKEEARKRNVP;RPLLGLLLL;STINSSDLRATAG 9 5.2 1.0018 -2.6276 0 8.48949 0 0 10.4126 11.1697 0 0 6.24829 0 8.5651 0 0 9.36696 0 A0A8I3PUK2 A0A8I3PUK2_CANLF Tripartite motif containing 59 TRIM59 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of viral entry into host cell [GO:0046597] endoplasmic reticulum [GO:0005783] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] TCPEHYRQPLNVYCLLDK;TEIGQIKKLL;VSNLINQEY 3 9.2 1.0032 -0.85885 9.10858 0 0 3.17311 0 0 0 0 0 3.28079 0 0 0 0 0 A0A8I3PUN1 A0A8I3PUN1_CANLF Nucleolar complex associated 4 homolog NOC4L Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nuclear membrane [GO:0031965] AEGVGEGPRGS;LGHELDSDPFDPEEGNPAE;QESVPLQFIPAQGLLGLQDDLCA;SEDSEEIREAVRAC 4 13.1 0.99378 -0.13025 0 0 0 0 0 0 0 12.8122 0 0 9.36019 0 8.53111 0 0 A0A8I3PUQ0 A0A8I3PUQ0_CANLF Somatomedin B and thrombospondin type 1 domain containing SBSPON Canis lupus familiaris (Dog) (Canis familiaris) LAGCADAG 1 3 0.98968 -0.26592 0 0 0 0 0 0 0 11.3709 0 0 0 0 0 0 0 A0A8I3PUQ7 A0A8I3PUQ7_CANLF "WD repeat, sterile alpha motif and U-box domain containing 1" WDSUB1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842] KDPVIASDGYSY;QDCQIKIWVVSFTHILARNTDDQV 2 9.4 0.98635 -0.23524 0 0 0 0 0 0 10.6511 0 0 0 0 0 0 0 6.83517 A0A8I3PUR3 A0A8I3PUR3_CANLF Transmembrane protein 107 TMEM107 Canis lupus familiaris (Dog) (Canis familiaris) craniofacial suture morphogenesis [GO:0097094]; detection of nodal flow [GO:0003127]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; regulation of gene expression [GO:0010468]; roof of mouth development [GO:0060021] membrane [GO:0016020]; MKS complex [GO:0036038] LSFFIFERWECTTYWYIFVF 1 14.3 0.95356 0.049514 0 0 0 0 0 0 0 0 6.63313 0 0 0 0 9.2666 0 A0A8I3PUS2 A0A8I3PUS2_CANLF G1 to S phase transition 2 GSPT2 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation release factor activity [GO:0003747] AKEKNRETWYLSWA;CWDQVDMEAPGSAPS;KNRETWYLSWALDTN;RLGRGAPVEHSKEEQ;TEKKHFTI;VPNVHAAEFVPSF 6 11 0.98912 -0.19689 9.71649 0 0 0 0 0 0 0 0 0 0 0 0 0 9.46693 A0A8I3PUT8 A0A8I3PUT8_CANLF Stereocilin STRC Canis lupus familiaris (Dog) (Canis familiaris) auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910] kinocilium [GO:0060091]; stereocilium tip [GO:0032426] AGLQAVPPSNQAWVQ;EGLLRVTDSLRNEVFS;FLGHQAGVL;FLGQLQVPPSEEQ;LAHLNQLQGFCLGE;LLPLLPLKLL;LLPLLPLKLLQ;LVAGVVRPTAEDL;QALVQVQPS;VLWDLLQREKSVWA;VRGSLRACIWAEL;VRRAPEQLLALTPLHRVALAE 12 8.4 1.0031 -2.367 0 5.40228 6.83958 8.05224 0 0 7.96509 11.4945 9.28566 3.93546 5.40187 0 10.6326 0 9.11634 A0A8I3PUU0 A0A8I3PUU0_CANLF Prokineticin receptor 2 PROKR2 Canis lupus familiaris (Dog) (Canis familiaris) circadian rhythm [GO:0007623] plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] DLKTSGMPATE;EQIRKRLRCRRK;LRNLTNLLIANLAISDFLV;YYKSYFLLIFGVE 4 14.3 0.9957 -0.095365 9.48349 9.46934 0 9.7828 10.0319 10.065 0 0 10.7124 10.9105 10.1366 10.1788 9.71795 0 0 A0A8I3PUV6 A0A8I3PUV6_CANLF GLI family zinc finger 2 GLI2 Canis lupus familiaris (Dog) (Canis familiaris) smoothened signaling pathway [GO:0007224] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ACTREQKPFKAQYMLVVHMRRHTGE;ALASQVKPSAFPQGNLAVVQQKPA;EPHSVHSVHGLGPLP;ESSGLCQSSPGAQSSCSSE;GGGGGGGA;GGGGGGGG;IVIHKRSKV;LTALDDTPPGADT;LVVHMRRHTGEKPHKCT;VGDMSSMLTSLAEES 10 9.3 0.95621 0.053877 0 0 0 0 0 0 9.40084 0 0 0 0 0 0 0 0 A0A8I3PUW3 A0A8I3PUW3_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)" PLCB4 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; phosphatidylinositol-mediated signaling [GO:0048015]; release of sequestered calcium ion into cytosol [GO:0051209] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] DLKRKILIKNKRLKP;HYNMSSFNESV 2 2.2 0.93734 0.089365 0 4.47612 0 5.65022 0 0 0 0 6.27316 0 0 0 0 0 0 A0A8I3PUW4 A0A8I3PUW4_CANLF Uncharacterized protein MZT2B Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737]; spindle [GO:0005819] LQKLALRRKKV;LQKLALRRKKVL;PDVFKILVDLLKL 3 16 0.8595 0.14551 0 0 0 3.78775 0 4.96315 0 0 0 0 0 0 3.75894 3.98968 0 A0A8I3PUX1 A0A8I3PUX1_CANLF Holliday junction recognition protein HJURP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] CCDVSGESP;DASGQKAD;DPASPRGPQAL;KVNKLKVCKLDPSWRE;PATPAHGCCD 5 7.1 1.003 -2.4797 4.14405 0 0 0 0 0 6.58091 0 0 0 0 9.8803 0 0 5.71246 A0A8I3PUX2 A0A8I3PUX2_CANLF Uncharacterized protein TMEM240 Canis lupus familiaris (Dog) (Canis familiaris) synaptic membrane [GO:0097060] EEPQGPLQ;GGAGRGGQ;SGRGRGGAGAGGRRSGP 3 7.7 1.0031 -1.5635 0 0 0 0 10.1186 0 0 0 0 0 0 11.8511 0 0 0 A0A8I3PUY3 A0A8I3PUY3_CANLF TATA box-binding protein-associated factor RNA polymerase I subunit B (TATA box-binding protein-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) TAF1B Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668] metal ion binding [GO:0046872]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164] LAFCYLSLLWQRE;SDLLRFVEEGHIPYIHAFQRFPEEM;VTTYEESN 3 7.8 1.0022 -0.65075 0 0 0 0 0 8.0114 0 0 0 0 0 8.68783 0 0 0 A0A8I3PUY5 A0A8I3PUY5_CANLF Protein naked cuticle homolog NKD2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] EDMSSLMHT;GDSSVVPAFA;PFWEDQCPLE 3 6.6 1.0031 -1.7345 7.22805 0 0 0 0 0 0 0 0 0 0 0 9.47314 0 0 A0A8I3PUZ1 A0A8I3PUZ1_CANLF Transmembrane 4 L six family member 1 TM4SF1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CCGCCGHENCG;EDDCCGCCGHENCG;EEDDCCGCC;EEDDCCGCCGHE;EEDDCCGCCGHEN;EEDDCCGCCGHENCG;FSSSQMLSSVLAALIGIAGS;TDGQYLLDTSTWS 8 20.7 1.0019 -1.4318 6.26894 0 7.53115 0 4.48562 3.12449 6.37931 0 9.01803 0 0 5.5246 0 6.93357 3.8845 A0A8I3PUZ2 A0A8I3PUZ2_CANLF DH domain-containing protein ARHGEF10 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] ALLSAVRGVQCQR;DPNNNEDDEGEQ;DVENGEEG;EQFDFDSGDE;MGQVAIVSFQNCNPKVIECF;SRRARQQRAAGAPG;VYVGPGQLY;WSVPLGHVE 8 6.6 0.99951 -2.8865 0 0 0 0 8.80732 0 9.95107 0 5.20656 6.4747 0 7.96492 0 7.72751 5.11636 A0A8I3PUZ6 A0A8I3PUZ6_CANLF Uncharacterized protein ARL4A Canis lupus familiaris (Dog) (Canis familiaris) brown fat cell differentiation [GO:0050873]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] QTSILSSLPSF;VDSVDVERMEEAKTELHKITRISEN 2 18 0.98857 -0.26114 0 0 0 0 0 0 11.7367 0 0 0 0 1.25556 0 0 0 A0A8I3PV04 A0A8I3PV04_CANLF Small ribosomal subunit protein mS33 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] FKDKQLRLKKLRGKGK 1 15.2 0.96102 0.049233 0 0 0 0 0 4.15955 0 0 0 0 0 0 0 0 0 A0A8I3PV05 A0A8I3PV05_CANLF Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) GNB5 Canis lupus familiaris (Dog) (Canis familiaris) dark adaptation [GO:1990603]; G protein-coupled dopamine receptor signaling pathway [GO:0007212]; light adaption [GO:0036367] cytosol [GO:0005829]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634]; presynapse [GO:0098793] G-protein gamma-subunit binding [GO:0031682]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087]; signaling receptor complex adaptor activity [GO:0030159] DVELHQVAERVE;GAGGGGGG;INSVRYYPSGDAFASGSDDA 3 7.7 0.9908 -0.51476 0 0 0 0 0 9.38096 0 0 0 0 0 0 0 0 11.6892 A0A8I3PV10 A0A8I3PV10_CANLF WW domain binding protein 1 like WBP1L Canis lupus familiaris (Dog) (Canis familiaris) CXCL12-activated CXCR4 signaling pathway [GO:0038160]; hemopoiesis [GO:0030097]; positive regulation of protein ubiquitination [GO:0031398] membrane [GO:0016020] ubiquitin protein ligase binding [GO:0031625] CCNYYYELW;CDTGHCCGQ;CDTGHCCGQSQC;ERVERVERQPSR;GPLDFCDSCHVRSPG;TNNQSYICDTGHCCG;VGTNNQSYICDTGHCCGQ 7 14.8 1.0042 -2.0214 0 0 5.9562 8.65524 7.55888 0 0 5.72391 0 0 0 0 0 9.07692 3.42747 A0A8I3PV16 A0A8I3PV16_CANLF Cytochrome P450 family 7 subfamily A member 1 CYP7A1 Canis lupus familiaris (Dog) (Canis familiaris) bile acid biosynthetic process [GO:0006699]; cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" KYLDWKKFHF;MDKWMLKLFNWKMNLCGYFLENV 2 6.6 0.98916 -0.21888 0 0 0 0 0 0 6.74658 0 0 0 0 0 9.66294 0 0 A0A8I3PV26 A0A8I3PV26_CANLF Potassium voltage-gated channel subfamily A regulatory beta subunit 3 KCNAB3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] oxidoreductase activity [GO:0016491]; voltage-gated potassium channel activity [GO:0005249] VGSVTWSPLSCGLIT;VLSQLTPQTVMEID 2 7.2 0.98687 -0.33613 0 0 14.2186 0 0 0 10.9064 0 0 0 0 0 14.4087 11.4389 14.288 A0A8I3PV37 A0A8I3PV37_CANLF Cytochrome P450 3A (EC 1.14.14.-) LOC119868939 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" DMKCFNPDMI 1 2.1 0.9876 -0.26469 8.48466 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PV38 A0A8I3PV38_CANLF DNA ligase (EC 6.5.1.1) LIG4 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to ionizing radiation [GO:0071479]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DN2 thymocyte differentiation [GO:1904155]; DNA biosynthetic process [GO:0071897]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; fibroblast proliferation [GO:0048144]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; stem cell proliferation [GO:0072089]; T cell receptor V(D)J recombination [GO:0033153]" condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; magnesium ion binding [GO:0000287] AAPKIKKII;AFNPNTQTFMQK;EVYIEPCNSVIVQV;KKRKAAPKIKKIIGII;KLAKHWKPFHKKAL;LGFSEQSVFSAFH;LKRKFKILQQ;TALELRFHGAKVVSCLAQGV 8 10.9 1.0024 -0.97057 7.5016 0 7.89075 0 0 7.84862 6.67821 10.5498 0 0 7.7211 0 3.29731 0 0 A0A8I3PV40 A0A8I3PV40_CANLF Synaptic Ras GTPase activating protein 1 SYNGAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096] DLQGDGPGGRL;EPKKRLLDAQRGSFP;FLELEWGSMQ;HSHESLLS;VLPQLSKEALLKLG 5 4.5 0.95608 0.053879 0 0 0 0 0 0 0 0 0 5.97145 0 0 0 0 0 A0A8I3PV49 A0A8I3PV49_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LHQLSQSD;TLSSVPLAQFGGQFF 2 20 1.005 -1.0499 0 0 0 11.8939 0 0 0 0 0 0 0 0 0 0 8.89415 A0A8I3PV50 A0A8I3PV50_CANLF Transmembrane protein 187 TMEM187 Canis lupus familiaris (Dog) (Canis familiaris) transport vesicle [GO:0030133] QALLHVAV 1 3 0.98942 -0.50887 7.21762 0 10.3867 10.7421 10.8289 0 0 0 0 9.06918 9.02495 9.01614 0 0 0 A0A8I3PV52 A0A8I3PV52_CANLF glutaminase (EC 3.5.1.2) GLS Canis lupus familiaris (Dog) (Canis familiaris) glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543] glutaminase activity [GO:0004359] FMSKFGFAMLC;SVRSRRRRRRLEEQQRRQERRRRR 2 4.9 0.98985 -0.22023 0 0 0 0 12.4114 0 8.46352 0 0 0 0 0 0 0 0 A0A8I3PV60 A0A8I3PV60_CANLF WASH complex subunit 3 (Coiled-coil domain-containing protein 53) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; WASH complex [GO:0071203] SLCTPHSLSPFS 1 8.8 0.94295 0.05044 0 9.55819 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PV72 A0A8I3PV72_CANLF Zinc finger protein 239 ZNF239 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDLVSPLV;SKLHIHQR;VIDLVSPLVS;VTEESTEKKVLRGESPS 4 11 0.99547 -0.5643 11.6251 0 0 0 0 0 13.414 0 11.5694 0 0 12.4432 0 0 9.74771 A0A8I3PV75 A0A8I3PV75_CANLF DEPP autophagy regulator 1 DEPP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] mitochondrion [GO:0005739]; peroxisome [GO:0005777] QQPAPTRDCTADPLDWLFGD 1 9.6 0.95357 0.050462 0 0 0 0 0 0 0 0 0 4.338 0 0 0 0 0 A0A8I3PV81 A0A8I3PV81_CANLF TSPY LOC119868780 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283] nucleus [GO:0005634] LTRKRGRLRRRPS;YVVSAAGYRASHSTPIQ 2 10.9 0.95169 0.059561 0 0 0 0 0 0 7.5988 0 0 0 0 0 0 0 0 A0A8I3PV89 A0A8I3PV89_CANLF DNA-directed RNA polymerases I and III subunit RPAC2 (DNA-directed RNA polymerase I subunit D) LOC111092404 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase I activity [GO:0001054]; RNA polymerase III activity [GO:0001056] EVEFCGYTTT 1 7.5 0.98907 -0.22689 0 0 0 0 0 0 0 0 9.03392 0 0 0 0 0 0 A0A8I3PVA0 A0A8I3PVA0_CANLF Somatoliberin (Growth hormone-releasing factor) (Growth hormone-releasing hormone) GHRH Canis lupus familiaris (Dog) (Canis familiaris) adenohypophysis development [GO:0021984]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; growth hormone secretion [GO:0030252]; multicellular organism growth [GO:0035264]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of multicellular organism growth [GO:0040018]; regulation of protein localization [GO:0032880]; response to food [GO:0032094] extracellular space [GO:0005615]; terminal bouton [GO:0043195] growth hormone-releasing hormone activity [GO:0016608]; growth hormone-releasing hormone receptor binding [GO:0031770]; neuropeptide hormone activity [GO:0005184] ILASLLQKRRNSQG 1 13.2 0.94179 0.061094 0 0 0 0 0 0 0 0 0 0 0 4.19794 0 0 0 A0A8I3PVA7 A0A8I3PVA7_CANLF Prothymosin alpha PTMA Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] histone binding [GO:0042393] AGDAAVDTSSEITTKDL;NEENGEQEADNEVDEEEEEG 2 28.7 0.97692 0.046227 0 0 0 0 0 0 0 0 0 6.48304 0 0 0 0 0 A0A8I3PVB3 A0A8I3PVB3_CANLF Slit guidance ligand 1 SLIT1 Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495] AMCSCSNG;CEGTECQNGANCVDQG;LNSECNSD;TCTGATVDCHGAGLQ;VGDNCSENQDDCRDH;VGDNCSENQDDCRDHRCQHG;VPSCTLSSGS;YTCQCPLQ 8 5.7 0.99714 -4.0788 0 0 0 0 0 0 0 4.51431 10.8556 0 0 8.04963 13.7641 8.75969 0 A0A8I3PVB8 A0A8I3PVB8_CANLF Cilia- and flagella-associated protein 251 CFAP251 Canis lupus familiaris (Dog) (Canis familiaris) DILFQKDYSANVYPLTMT;EMEEDYNYRGMESMQQE;ETEEDGETEMEEDYNYRGM;IMSGTFLPSSEP;IVNWYSHFKLSSI;LGQERRDLEP;LTKGEHMTEEE;LVAGGREGKFYRELEDY;PVYYIRDENQ;SELPFVMRAIG 10 10.9 1.003 -0.78495 9.99195 11.5184 0 8.99628 6.44196 0 0 11.4556 0 0 0 0 10.7951 4.56291 0 A0A8I3PVC2 A0A8I3PVC2_CANLF Moesin (Membrane-organizing extension spike protein) MSN Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; cytoskeleton [GO:0005856]; microvillus membrane [GO:0031528] actin binding [GO:0003779] HAENMRLGRDKYKTLRQI;HVAEPAENEQDEQDENGAEA;LAGDKLLPQRVLEQHKL;QDITQRLFFLQ 4 12.1 0.99214 -0.14042 0 0 0 0 9.15795 0 0 0 0 5.95852 3.81352 0 0 0 0 A0A8I3PVD0 A0A8I3PVD0_CANLF Aurora kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic spindle organization [GO:0007052]; regulation of cytokinesis [GO:0032465] chromosome passenger complex [GO:0032133]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; neuron projection [GO:0043005]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] KENCIAGPVKTTIALDFEI;REVEIQSHLKHPNILWLYGI 2 42.4 0.99091 -0.18545 0 0 0 0 0 0 0 5.29734 0 0 0 0 0 0 10.8279 A0A8I3PVD2 A0A8I3PVD2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AGNATASASACEGLP;GGGGMALG;IAALRWGPGGPAALH 3 11 0.98646 -0.32872 0 0 0 0 0 8.6004 0 12.2557 0 0 0 0 0 0 0 A0A8I3PVD3 A0A8I3PVD3_CANLF Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65) CCDC65 Canis lupus familiaris (Dog) (Canis familiaris) axonemal dynein complex assembly [GO:0070286]; regulation of cilium movement [GO:0003352] axonemal dynein complex [GO:0005858]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514] LSQENLVKLTVESNAAL;SEDQNQYIRKDKEL;WRTVLREVKTRE 3 8.7 0.98632 -0.41124 11.5572 0 0 0 0 0 0 0 0 0 0 12.5808 0 9.64571 0 A0A8I3PVD7 A0A8I3PVD7_CANLF "Leucine, glutamate and lysine rich 1" LEKR1 Canis lupus familiaris (Dog) (Canis familiaris) EEKVCKYC;LVEPESKYIYI;RMWETKEINRYECPGTP 3 21.7 0.98737 -0.46599 0 0 0 0 0 0 9.67046 0 0 0 0 0 0 0 9.35423 A0A8I3PVD8 A0A8I3PVD8_CANLF Periostin POSTN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; regulation of Notch signaling pathway [GO:0008593]; tissue development [GO:0009888] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; trans-Golgi network [GO:0005802] cell adhesion molecule binding [GO:0050839]; heparin binding [GO:0008201]; metal ion binding [GO:0046872] AGNQQTTFTDLVAQ;EETLKKLL;GDTPVKKI;IMGDKVASEALM;KIITKVVEPKIKVIEGSLQ 5 7.3 1.0034 -2.2499 0 0 0 0 0 0 0 0 0 13.9014 0 5.78492 5.92412 0 6.07972 A0A8I3PVE8 A0A8I3PVE8_CANLF MAGE domain-containing protein LOC119868340 Canis lupus familiaris (Dog) (Canis familiaris) KTAELVMFLLLKYRTK 1 3.4 0.96338 0.049233 0 0 0 0 0 0 7.01179 0 0 0 0 0 0 0 0 A0A8I3PVF0 A0A8I3PVF0_CANLF Acyl-CoA thioesterase 7 ACOT7 Canis lupus familiaris (Dog) (Canis familiaris) acyl-CoA metabolic process [GO:0006637]; palmitic acid biosynthetic process [GO:1900535] cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654] fatty acyl-CoA hydrolase activity [GO:0047617] EVAGIVAARHC;EVAGIVAARHCKT;TASVDAINFHDKI 3 7.9 0.66154 0.30817 0 12.7152 0 12.2242 12.2623 0 12.899 0 12.8482 12.8271 12.4883 12.5883 10.0764 0 11.996 A0A8I3PVF2 A0A8I3PVF2_CANLF Fatty acid 2-hydroxylase (EC 1.-.-.-) FA2H Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] endoplasmic reticulum membrane [GO:0005789] fatty acid alpha-hydroxylase activity [GO:0080132]; heme binding [GO:0020037]; iron ion binding [GO:0005506] YHMKAHHAKHH 1 3 0.98087 0.035491 0 0 0 0 0 0 0 0 9.66564 0 0 0 0 0 0 A0A8I3PVF8 A0A8I3PVF8_CANLF EF-hand domain-containing protein MCFD2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EQSPLCWDWPAGALQPGRGS;SPQELQLHYFKMHD;VGLDKNTVHDQ 3 15.9 0.96554 0.048658 7.51041 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVG5 A0A8I3PVG5_CANLF Motile sperm domain-containing protein 1 MOSPD1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] AALMLPTLGDVE;MHQQKRQPELVEGN 2 12.1 0.98902 -0.26309 0 0 0 0 0 0 0 9.27244 0 0 0 0 0 0 0 A0A8I3PVI4 A0A8I3PVI4_CANLF Coiled-coil domain containing 38 CCDC38 Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; intraciliary anterograde transport [GO:0035720]; sperm flagellum assembly [GO:0120316] centrosome [GO:0005813]; manchette [GO:0002177]; perinuclear region of cytoplasm [GO:0048471]; sperm flagellum [GO:0036126]; sperm head [GO:0061827] ubiquitin-modified histone reader activity [GO:0061649] VGSLNPVQKLV 1 1.9 0.98516 0.035491 9.23879 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVJ2 A0A8I3PVJ2_CANLF Protocadherin 10 PCDH10 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEPGYLLTRVAAVDA;ASDCCLCCCCC;ASDCCLCCCCCG;ASDCCLCCCCCGG;ASDCCLCCCCCGGGGS;CCCCCGGGGSACC;CCCCCGGGGSACCGRQ;CCCCCGGGGSACCGRQA;CCCCGGGG;CCCCGGGGSACCGRQARAR;CCCGGGGSAC;CCLCCCCCGGGGSAC;CCLCCCCCGGGGSACC;CLASDCCLCCCCCGG;CLASDCCLCCCCCGGGGSAC;CLCCCCCGGGGSACC;DCCLCCCCC;DCCLCCCCCG;DCCLCCCCCGGGG;DCCLCCCCCGGGGS;DCCLCCCCCGGGGSACCGRQARAR;GGGGGGGE;GGGGGGGG;GGGGGGPG;LASDCCLCCCCCGG;LASDCCLCCCCCGGGGSACCGRQ;LDSNDNVPAF;PGGGGGGG;PPGGGGGGG;SDCCLCCCCC;SDCCLCCCCCG;SDCCLCCCCCGG;SDCCLCCCCCGGG;SDCCLCCCCCGGGGS;SDCCLCCCCCGGGGSACCG;SDCCLCCCCCGGGGSACCGR;SFKNYYTIVTEA;TCLASDCCLCCCCCGGGG;TCLASDCCLCCCCCGGGGSACCGR;VYVTENNVPG;YTCLASDCCLCCCCCGGGGSACC;YTCLASDCCLCCCCCGGGGSACCG;YTCLASDCCLCCCCCGGGGSACCGR 43 10.1 0.99683 -7.6639 8.47917 8.79867 12.188 5.70219 8.39176 9.07438 9.27417 5.01038 10.4066 11.7901 12.2155 11.5531 12.1747 12.0645 12.2701 A0A8I3PVL0 A0A8I3PVL0_CANLF Carnitine O-acetyltransferase CRAT Canis lupus familiaris (Dog) (Canis familiaris) "carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]" mitochondrion [GO:0005739]; peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092] AFVQMALQLAYYRIYKQACATYES;DTIRSASMDSLTFVKAMDDP;ERRARKTENWLSEWWLKT 3 9.9 0.87581 0.13977 0 0 0 0 0 0 0 6.97005 8.71963 0 0 0 9.05962 0 0 A0A8I3PVL2 A0A8I3PVL2_CANLF Prothymosin alpha PTMA Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AVEASRGPE;NEENGEQEADNEVDEEEEEG;VPRPARKA 3 10.4 1.0028 -1.3483 0 0 0 0 0 0 0 0 0 2.51382 0 0 0 0 0 A0A8I3PVL3 A0A8I3PVL3_CANLF BLOC-1-related complex subunit 5 BORCS5 Canis lupus familiaris (Dog) (Canis familiaris) lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]; positive regulation of anterograde synaptic vesicle transport [GO:1903744] BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; synaptic vesicle membrane [GO:0030672] RRIQMGIDQTVPL 1 8.8 0.93728 0.059741 0 0 10.0666 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVL8 A0A8I3PVL8_CANLF PIG-P domain-containing protein PIGP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAGSCGGC;PVYLLIIILIGYVLLFGIN;SPLPERAIY 3 8.8 1.0039 -1.1044 0 0 0 5.80465 6.44946 0 0 0 0 0 0 0 0 0 0 A0A8I3PVM4 A0A8I3PVM4_CANLF Paired box 6 PAX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KKKKKKKK;KKKKKKKKNKY;KKKKKKKN;LLEALQFCSCVLCCTTGMD;SKKKKKKKKK 5 10.7 0.98889 0.035491 0 0 0 0 0 0 0 0 0 0 0 6.96359 0 0 0 A0A8I3PVP2 A0A8I3PVP2_CANLF SS nuclear autoantigen 1 SSNA1 Canis lupus familiaris (Dog) (Canis familiaris) axon arborization [GO:0140060]; axon extension [GO:0048675]; cell division [GO:0051301]; intraciliary transport [GO:0042073]; microtubule nucleation [GO:0007020]; receptor clustering [GO:0043113] axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; midbody [GO:0030496]; plasma membrane [GO:0005886]; supramolecular fiber [GO:0099512] identical protein binding [GO:0042802]; microtubule binding [GO:0008017] LCQKREELCRQIQQEEDEKQ;MTQQGAALQ 2 24.4 0.99123 -0.037162 0 0 0 0 8.989 0 0 0 7.77551 0 0 0 0 0 0 A0A8I3PVQ0 A0A8I3PVQ0_CANLF WD repeat domain 72 WDR72 Canis lupus familiaris (Dog) (Canis familiaris) enamel mineralization [GO:0070166]; extracellular matrix disassembly [GO:0022617]; protein localization to plasma membrane [GO:0072659] endosome [GO:0005768]; nucleus [GO:0005634] EGKRCLLHAR;ESKFLDSVNCRTIRFC;ISCWRDQSVQVTEVIQ;KIYDYCDFS;LFLSCFLPWGVDKELDNL;LLEGGSLLKGSL;QDTEDMPDRCVLEESE;TIRFCTYTE 8 9.1 1.0029 -1.7238 0 0 10.1906 4.65753 5.11844 12.0557 0 0 8.70328 0 0 0 0 8.90427 0 A0A8I3PVQ5 A0A8I3PVQ5_CANLF Uncharacterized protein LOC111094789 Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on ester bonds [GO:0016788]" LHDQSSSTI;SEEDQSQNYHPFHFSRNLEMEE 2 5 0.99563 -0.56824 0 0 0 0 0 0 10.704 0 0 0 0 0 0 0 0 A0A8I3PVR0 A0A8I3PVR0_CANLF "SPG11 vesicle trafficking associated, spatacsin" SPG11 Canis lupus familiaris (Dog) (Canis familiaris) AAGCSSCGAE;ARIDFWKKCHE;CHENFKKNSISSKAASS;CKRAQAFISTQ;CSRSPQELQRNKE;DLLHKKHY;EAYDFVPD;EDSHNGSS;EIIKSSKWEVPCCAPW;ELLKNMGFDVKDQL;ETAATRVHT;FTSLKVSQDLDV;GFVHEASRVCRY;GPFRHFIWE;GVSQVVQDDE;ILFVLSSLGW;LDYIKRCRPGDSE;LMMEMYELCMFFK;LVQCRQVSSNLTDPKLIF;PGTPLTQVTGSG;QDEIHSHYKFPQ;QQMFAPAEESRTFL;QVGNEAYVLGLS;SCLQDASTI;VLASCLQDASTI;WEKLSIEEVIANAILN 26 12.4 0.99682 -5.6624 5.43346 12.4032 10.7424 0 10.0817 8.08028 10.8092 12.6203 10.2577 0 14.255 11.7861 11.1281 11.3425 10.9643 A0A8I3PVR2 A0A8I3PVR2_CANLF Matrix AAA peptidase interacting protein 1 MAIP1 Canis lupus familiaris (Dog) (Canis familiaris) calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial membrane [GO:0051204] mitochondrial matrix [GO:0005759] AGLCCFCRRRLGSGA;LAVRLRPRLLLSL;VRLRPRLLLSLP 3 10.1 0.9944 -0.15549 4.47346 0 0 0 0 0 0 0 0 0 0 0 0 0 5.63323 A0A8I3PVR3 A0A8I3PVR3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP22 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] DAGKHIPG;IDPFWDISL;PGSEGSVVNGESHVA;SSCLVCEMSSLFQEFY 4 8.9 0.98457 -0.25722 9.50414 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVR9 A0A8I3PVR9_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TTC3 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; transferase activity [GO:0016740] AENAPGNQIVPKTQ;ALKKVALRLKKKRK;ALKKVALRLKKKRKK;ALKKVALRLKKKRKKKNI;ALRLKKKRKKKNIKT;CIALKKVALRLKKKRKKK;DNCIALKKVALRLKKKRKKKNIK;EVNPEKNNEVTNTPHTQMVAIQ;GYKIENKILAMEEALNWVKYT;HQEVNTEPYDPFE;IALKKVALRLKKKRKKKNI;IDNCIALKKVALRLKKKR;KEIQESLKALTKKMRKVL;KKVALRLKKKRKKKN;LKKVALRLKKKRKKK;LKKVALRLKKKRKKKNIK;LKKVALRLKKKRKKKNIKT;LNFVETEKDSRKTNREMA;LRLKKKRKKKNIK;SEISLKKLQHLELMEDI;SISTSHEAGN;TEDYTTCFS;VLNANEINTFTNEK 23 9.1 0.98494 -0.24635 0 0 0 8.2512 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVS0 A0A8I3PVS0_CANLF Voltage-dependent L-type calcium channel subunit alpha CACNA1D Canis lupus familiaris (Dog) (Canis familiaris) calcium ion import across plasma membrane [GO:0098703] voltage-gated calcium channel complex [GO:0005891] high voltage-gated calcium channel activity [GO:0008331]; metal ion binding [GO:0046872] AFRVLRPLRL;AISVVKILRVLRVLRPLR;AVIGMQMF;DPTESENVPVPTATPGNSE;GPVSHRQDYELQ;ISVVKILRVLRVLRPL;ISVVKILRVLRVLRPLRAI;KRLVAMNMPLNSDG;NRNNNFQTFPQAV;SAISVVKILRVLRVLRPLRA;SVVKILRVLRVL;SVVKILRVLRVLRPLRAINRA;VGKYPAKNT;VIFGSFFVLNLV;VIKKIWKKTSMKLLDQV;VLRVLRPLRAINRAKG;VVQCVFVAIR;YIPKNPYQYKFWYVVN 18 7.7 1.0004 -0.93097 0 0 0 8.86 8.66527 0 0 0 5.72077 7.26716 0 0 0 0 0 A0A8I3PVS1 A0A8I3PVS1_CANLF Calpain 15 CAPN15 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; metal ion binding [GO:0046872] IVVVENRHP;LNAPRAKHCAACHTPQ;LSVEEQKWP;SCSACGGP;VGRPGGQGGGRAPGGRGRGTPP 5 5.4 1.0035 -1.6213 0 7.50239 0 0 8.06711 2.88458 0 8.48281 0 0 0 0 2.78058 0 0 A0A8I3PVT1 A0A8I3PVT1_CANLF Jumonji domain containing 8 JMJD8 Canis lupus familiaris (Dog) (Canis familiaris) DTGDGGWY;KVDLPFQDYVEHLLHPQD;LECTVQAGEVLYFPDRWWHATLNL 3 21.1 1.0025 -1.3423 0 0 0 0 0 8.30907 0 6.05656 5.72585 0 0 0 0 0 12.9805 A0A8I3PVT3 A0A8I3PVT3_CANLF Cilia and flagella associated protein 54 CFAP54 Canis lupus familiaris (Dog) (Canis familiaris) cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; sperm flagellum assembly [GO:0120316] extracellular region [GO:0005576] DVKVSWYCILGCKA;ELQAEFLMQA;IMFLWQKCKLGIQRVNLSRNDYAK;IVNKFEMYTSLAWIVIRAA;IYHNIVLVPVIQILIKCV;KKNKLSKAI;LVYAQRQLLLRISK;QTKVDITWILLLRYYIH;QVLQTPTD;SEEFLSKVGIWGCLQGA;SIPAGCKA;SVSPGASATE;VFSTLRLLQDSKLFKKKVVQ;VIHCYKMEDIDIVMVAEV;VLKGSVDVLPILKKKPVEQLFLA;YTAVCQCYY 16 7.7 0.99709 -4.0791 12.1657 5.75668 7.46671 0 8.05523 14.6095 15.1573 15.2266 4.20203 0 0 0 14.6421 0 11.3741 A0A8I3PVU2 A0A8I3PVU2_CANLF Espin ESPN Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] stereocilium [GO:0032420] actin binding [GO:0003779] AENGELECC;EERQKQEELQREKE;PLPAGPGMAHSEEVRA;REQRRKEEERQKQEELQ 4 5.4 0.91789 0.11381 8.34292 0 10.6703 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PVU5 A0A8I3PVU5_CANLF Histone PARylation factor 1 HPF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974] chromosome [GO:0005694]; nucleus [GO:0005634] histone binding [GO:0042393] AAIKLFLMK;GGGKRKPG;HYKLSLPEDFYHFWKFCEE 3 10.4 0.98988 -0.26592 0 9.66267 0 0 0 0 0 0 0 0 9.00722 0 0 0 0 A0A8I3PVU6 A0A8I3PVU6_CANLF 40S ribosomal protein S6 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] PKIQRLVTPRVLQHKRRRIAL;RLVTPRVLQHKRRRIALKKQ;VLRRVGPKRASRI 3 14.9 0.94398 0.059561 0 0 0 0 5.31701 0 0 0 0 0 0 0 0 0 0 A0A8I3PVW5 A0A8I3PVW5_CANLF Ubiquitin conjugating enzyme E2 E3 UBE2E3 Canis lupus familiaris (Dog) (Canis familiaris) EITFMNGDRLYLVHQVLYMK 1 10.4 0.9854 -0.23555 0 0 9.1879 0 0 0 0 0 0 0 0 0 0 0 9.05028 A0A8I3PVX0 A0A8I3PVX0_CANLF Thymosin beta LOC102152706 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin monomer binding [GO:0003785] EKNPLPSKETIEQE;EKNPLPSKETIEQEKQAGES;ETIEQEKQAGES;KNPLPSKETIEQEKQAGES;KTETQEKNPLPSKETIEQEKQAGES;NPLPSKETIEQEKQAGES;PLPSKETIEQEKQAGES;SDKPDMAEIE;SDKPDMAEIEK;SDKPDMAEIEKF;SDKPDMAEIEKFD;SDKPDMAEIEKFDKS;SDKPDMAEIEKFDKSKL;SDKPDMAEIEKFDKSKLKKTET;SKETIEQEKQAGES;TETQEKNPLP;TETQEKNPLPSKETIEQEKQAGES;TQEKNPLPSKETIEQEKQAGES 18 97.7 0 34.607 14.9339 14.8407 14.6587 14.8161 15.0974 15.1867 16.0067 15.8689 15.8587 13.6717 13.5169 13.4206 15.2197 15.4237 15.3253 A0A8I3PVX1 A0A8I3PVX1_CANLF ADP dependent glucokinase ADPGK Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" SLWSSLQLAPAPPG;VLSGLHMME;VSSLEEFQPDLVVLS 3 7.4 1.0018 -0.67547 0 0 0 0 0 0 0 8.08151 10.1144 9.52135 0 0 0 0 0 A0A8I3PVX4 A0A8I3PVX4_CANLF Dynein light chain Tctex-type family member 5 DYNLT5 Canis lupus familiaris (Dog) (Canis familiaris) TVSYMDEPSQWD 1 5.9 0.9495 0.05044 0 0 0 0 0 0 0 0 0 9.62901 0 0 0 0 0 A0A8I3PVX6 A0A8I3PVX6_CANLF Small integral membrane protein 11 SMIM11 Canis lupus familiaris (Dog) (Canis familiaris) NWKVLEHVPLLLYILAAK 1 31 0.96575 0.048313 0 0 0 0 0 0 0 0 8.72697 0 0 0 0 0 0 A0A8I3PVY3 A0A8I3PVY3_CANLF Protein YIPF YIPF6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] IVMFAWSIVASTAFLADSQPPN 1 11.4 0.96096 0.048954 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.45992 A0A8I3PVY8 A0A8I3PVY8_CANLF Homeodomain interacting protein kinase 1 HIPK1 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; smoothened signaling pathway [GO:0007224] cytoplasm [GO:0005737]; PML body [GO:0016605] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] CFQHKNHTCLVFEMLEQNLY;DSPDSDSSLSSPYST;ETGIKSKEARK;ISQTQGLPAEYLL;KRSTKEIVAIKILKNHPSYA;PTGYRVPRGGT;SLLEPYQKCGLKRKS;TSSIAHLFSPQGSSRHAAA;VGPSLLTS;VPGVAQQG 10 12 0.99769 -3.3705 0 0 10.6128 6.76911 0 14.4376 10.5846 0 9.13127 9.92638 9.68519 11.2898 10.7368 10.3625 7.7998 A0A8I3PVZ0 A0A8I3PVZ0_CANLF "Centrobin, centriole duplication and spindle assembly protein" CNTROB Canis lupus familiaris (Dog) (Canis familiaris) centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410]; regulation of cilium assembly [GO:1902017] centriole [GO:0005814]; centrosome [GO:0005813] protein domain specific binding [GO:0019904] DLLSDPSDVPGLNQ;QETVTHLEQ;REEDSFDSDSTATLL;RKGGHSGP 4 5.1 0.9944 -0.12712 0 12.1659 0 10.8225 0 7.83137 0 9.36842 0 0 12.0111 0 0 11.8953 0 A0A8I3PW08 A0A8I3PW08_CANLF Mitochondrial thiamine pyrophosphate carrier (Solute carrier family 25 member 19) SLC25A19 Canis lupus familiaris (Dog) (Canis familiaris) thiamine diphosphate biosynthetic process [GO:0009229] mitochondrial inner membrane [GO:0005743] antiporter activity [GO:0015297]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422] FQLQIERLSRS;MYRTEGPLV;YDARDFSVHFVCG;YPLDLFKKRLQVG 4 14.5 0.99126 -0.54692 0 0 0 10.1403 7.76215 0 0 0 0 11.9395 0 0 11.9556 12.5202 0 A0A8I3PW14 A0A8I3PW14_CANLF Ring finger protein 13 RNF13 Canis lupus familiaris (Dog) (Canis familiaris) EDGDKLRI;EDTDSSDAENEINAHSVV;ITKFVQDRHRA;TESSDYEEEDNEDTDSSDAENE 4 20.3 0.98726 -0.37903 0 0 0 0 0 0 5.25535 0 5.301 0 0 0 8.69314 0 0 A0A8I3PW20 A0A8I3PW20_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EDILPYTSTDQVPIQ;WRRLVYLRCQNRM 2 8.5 0.94238 0.059561 0 0 0 0 0 0 0 2.66485 0 0 0 0 0 0 0 A0A8I3PW33 A0A8I3PW33_CANLF Metalloprotease TIKI (EC 3.4.-.-) (TRAB domain-containing protein 2) TRABD2B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oxidation [GO:1904808]; positive regulation of protein-containing complex assembly [GO:0031334]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] organelle membrane [GO:0031090]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147] AFGAGHFL;AVERVEEQCHPLNGLN;DVLPRDLYWRLKR;LGNLRSQSRPHRLPSLPLQQ;TPAGQTIHSPA 5 14.5 0.94939 0.050109 0 0 8.51365 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PW34 A0A8I3PW34_CANLF Paired box 4 PAX4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of epithelial cell differentiation [GO:0030858]; type B pancreatic cell differentiation [GO:0003309] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CPLLPVTF 1 2.3 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 9.07436 0 A0A8I3PW37 A0A8I3PW37_CANLF Vacuole membrane protein 1 VMP1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagosome membrane docking [GO:0016240]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; lipoprotein transport [GO:0042953]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; vacuolar membrane [GO:0005774] phospholipid scramblase activity [GO:0017128] DLAGITCG;DQIICPDEDGIEGTI;PPYPDQIICPDEDGIEG 3 6.7 0.98499 -0.44397 12.2602 0 0 12.6666 0 0 0 0 0 13.4647 0 0 6.09576 0 0 A0A8I3PW39 A0A8I3PW39_CANLF RING-type domain-containing protein PCGF6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] PRC1 complex [GO:0035102] metal ion binding [GO:0046872] EEEEEEEEEEMSHFSLRLEG;GANEGTGH;GVGKAEGAGAMPPPPAVS 3 14.6 1.0028 -1.0079 0 0 0 0 0 0 10.0676 7.69711 0 0 0 8.3651 0 0 0 A0A8I3PW42 A0A8I3PW42_CANLF Collagen type II alpha 1 chain COL2A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201] EAGAPGLV;GAPGFPGP;KGASGPAGPPGAQGPP;PGTPGLPGV;VGPSGAPGE 5 3.5 1.0031 -2.1259 0 8.32035 0 0 10.4986 10.0411 0 0 0 11.589 10.5151 0 0 10.9198 0 A0A8I3PW46 A0A8I3PW46_CANLF Fascin FSCN3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674] PEELRVGLI 1 1.8 0.99217 -0.27195 0 0 0 0 0 0 0 0 0 0 0 10.7596 0 0 0 A0A8I3PW49 A0A8I3PW49_CANLF Transmembrane protein with metallophosphoesterase domain TMPPE Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hydrolase activity [GO:0016787] DVSNWFALLESLNVRP;PGGGEGDD;SMIVSRSYLAGSLELG 3 8.9 0.98957 -0.2632 0 0 0 0 7.4733 0 0 0 0 0 0 0 0 0 0 A0A8I3PW53 A0A8I3PW53_CANLF Apoptosis inducing factor BLCAP (Bladder cancer-associated protein) BLCAP Canis lupus familiaris (Dog) (Canis familiaris) apoptotic nuclear changes [GO:0030262] membrane [GO:0016020] LPESAHDP 1 9.2 0.98946 -0.2632 0 0 0 0 0 0 8.2034 0 0 0 0 0 0 0 0 A0A8I3PW54 A0A8I3PW54_CANLF Myosin XVIIIB MYO18B Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAWKAGEP;AGDAERSQAASALSRART;ATFEELCHNYAHERL;EEVVSSDS;FSSCESLFESGQNVG;KDKESVLPSKAEK;MRIEYLEQ;PAHLGSLAK;PATDPGGEKKGGTPGTPRGPQ;PLGLEDWPTLPIYQTTG;RFAMVMSLDFNATGRVTAAQLQ;SLATDTMRSPSR;SPLCLRRQKYYH;SPQRSRIHFETE;VLESERAERQRAFREV 15 8.2 0.98897 -0.26225 0 8.57716 0 0 0 0 8.66523 0 8.55313 0 0 0 0 0 0 A0A8I3PW56 A0A8I3PW56_CANLF 2-hydroxyacyl-CoA lyase (EC 4.1.2.63) LOC608697 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] GVCLVVSGPGLIHALGGMANA;KGDLGVMGLPGSRGPMGFKGYP;LEQFDKTPWQYPPESSWWQT;PTNVNNPSYRESMFG;WCFPSGQVTNT 5 8.4 0.76454 0.23545 9.09146 0 0 0 0 14.0077 7.28263 0 0 0 0 0 8.33557 0 0 A0A8I3PW60 A0A8I3PW60_CANLF Protein ABHD8 (Alpha/beta hydrolase domain-containing protein 8) ABHD8 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] EVELADPA;GSGEPPAA 2 3.7 1.0029 -0.84802 0 0 0 0 7.38612 0 0 9.39448 0 9.88673 3.42331 0 0 0 3.32099 A0A8I3PW68 A0A8I3PW68_CANLF CD99 antigen-like protein 2 CD99L2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GGRGTEPAGPPATRSRST;SPLENWGGGRGTE 2 5.6 0.91658 0.11182 8.74843 0 0 0 0 0 0 7.5274 0 0 0 0 0 0 0 A0A8I3PW69 A0A8I3PW69_CANLF Nuclear casein kinase and cyclin dependent kinase substrate 1 NUCKS1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297] cytoplasm [GO:0005737] double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697] DEDFLMEDDDDSDYG;EDDDDSDY;EMLMEDVGSEEEQEEEDEAPFQ;FQEKDSGSDEDFLMEDDDDSDYG;KSKPERKEKKMP 5 22.6 0.99728 -0.10609 0 0 0 0 0 7.55697 5.47975 11.634 0 6.08049 0 0 0 0 0 A0A8I3PW74 A0A8I3PW74_CANLF DENN domain containing 2C DENND2C Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] FRAGEVANRKKKNLPRLVLKI;LCRPLDSRLEHVDFE;LIRVCASL;MPCKERNCDRKYCEN;SELKSETFSFVLTGED 5 8 0.98747 -0.33453 0 10.8771 0 0 0 0 9.84923 0 0 0 0 0 6.47826 11.6395 0 A0A8I3PW75 A0A8I3PW75_CANLF Ciliary microtubule associated protein 1A CIMAP1A Canis lupus familiaris (Dog) (Canis familiaris) KLGSFSDDLHKTP 1 5.1 0.94497 0.059647 0 0 0 0 0 0 0 0 0 0 0 10.4028 0 0 0 A0A8I3PW76 A0A8I3PW76_CANLF "SEC22 homolog A, vesicle trafficking protein" SEC22A Canis lupus familiaris (Dog) (Canis familiaris) TPAGGMSN 1 8.1 1.0041 -1.1044 0 0 0 0 9.4191 0 0 0 0 0 0 0 0 0 0 A0A8I3PW78 A0A8I3PW78_CANLF Metastasis associated 1 family member 3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] TATGNVEAKVVCFY;TPNHTSLSILGKRNYSHH;TVKQTWGGP;YKPNPNQISASNGKPG 4 9.6 0.99164 -0.14837 0 0 0 0 9.44706 0 0 0 0 0 0 0 0 0 0 A0A8I3PW79 A0A8I3PW79_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP22 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] IDPFWDISL;PGSEGSVVNGESHVA;SSCLVCEMSSLFQEFY;VLDSEGYLLFYHKQFL 4 10.7 0.98719 -0.35515 0 0 0 0 9.63078 7.07136 0 0 3.92733 0 0 8.92211 12.6905 0 0 A0A8I3PW81 A0A8I3PW81_CANLF "H1.4 linker histone, cluster member" H1-4 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] heterochromatin [GO:0000792]; nucleosome [GO:0000786]; nucleus [GO:0005634] chromatin DNA binding [GO:0031490]; histone deacetylase binding [GO:0042826]; structural constituent of chromatin [GO:0030527] TPKKSAKKTPKKAKKPAAAAG 1 9.6 0.97555 0.047166 0 0 0 0 0 0 0 0 0 0 3.90487 0 0 0 0 A0A8I3PW84 A0A8I3PW84_CANLF EF-hand domain-containing protein FLG Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914] DQAHDNTRHSGSHE;EDSERQYGSGPGNQGESAHGHAR;QERSRSSQRR 3 2.7 1.0037 -0.8127 0 4.34248 0 0 0 0 0 0 10.0297 0 0 9.57932 0 0 0 A0A8I3PWB2 A0A8I3PWB2_CANLF MIF4G domain containing MIF4GD Canis lupus familiaris (Dog) (Canis familiaris) regulation of translational initiation [GO:0006446] cytosol [GO:0005829] translation activator activity [GO:0008494] LLLLEIIE 1 4.7 0.98998 -0.26592 7.76228 0 0 0 0 0 0 7.79461 0 0 0 0 0 0 0 A0A8I3PWB7 A0A8I3PWB7_CANLF EF-hand domain-containing protein TCHH Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] AKPAEREQLREE;EEQRRDSKWQWQ;EQELRGEQGRREQL;EQRLEQELGREQELRHEQELRREEQ;ERDRKFREEEQLLQEREEQLRRQER;LQDPRQKEDQ;LQREEQVRRLEAEE;PHDPETVDLI;PLYEYIQEQRSQYR;REQLRREEQRLEQQQRREQQLA;RNEQRLEQELRREQE;RNEQRLEQELRREQEERREQELRRE 12 34.2 1.0022 -1.3706 9.53572 5.17437 8.38284 0 5.65598 0 8.31198 8.00377 10.2879 0 9.02384 0 10.882 0 0 A0A8I3PWC7 A0A8I3PWC7_CANLF Adrenomedullin 2 ADM2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628] extracellular region [GO:0005576] protein-containing complex binding [GO:0044877] LSRSLGGSQQPAPPREPP 1 12.7 0.98494 -0.23869 0 0 0 9.7415 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWD5 A0A8I3PWD5_CANLF Cytosolic iron-sulfur assembly component 3 CIAO3 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244]; intracellular oxygen homeostasis [GO:0032364]; iron-sulfur cluster assembly [GO:0016226]; regulation of gene expression [GO:0010468]; response to hypoxia [GO:0001666] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361] LCSSMSAQEPSSH;PGRPENDEVQDCIKPVKV;YVEVMACPAGCL 3 7.8 0.99707 -0.59403 0 0 0 0 0 0 0 0 0 0 7.17961 0 0 0 0 A0A8I3PWE0 A0A8I3PWE0_CANLF Signal transducer and activator of transcription STAT1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ACIGGPPNACL;EERKILENAQ;HDLLSQLDDQYS;IWMSQWYELQQLDSKFLEQVHQLYD;LVLKTGVQFTVKLRLLVKL;NMLVTEPRNLSFFLNPPCARWSQL;TVKLRLLVKLQ;VLKTGVQFTVKLRLLVKLQELN;VTFPDIIRNY 9 16.1 0.97863 0.035538 0 0 0 0 0 5.06919 0 0 0 5.57413 0 0 0 0 0 A0A8I3PWF5 A0A8I3PWF5_CANLF Zinc finger protein 750 ZNF750 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; establishment of skin barrier [GO:0061436]; membrane biogenesis [GO:0044091]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of gene expression [GO:0010628] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PPGPVPKHLNPPSAYDH 1 2.4 0.9862 -0.25964 11.8358 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWG0 A0A8I3PWG0_CANLF "Small ribosomal subunit protein mS25 (28S ribosomal protein S25, mitochondrial)" MRPS25 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KQLSHPAHFGPRKYCLRECICEV 1 13.3 0.99061 -0.27329 10.482 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWG3 A0A8I3PWG3_CANLF RUN and FYVE domain containing 4 RUFY4 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; cellular response to interleukin-4 [GO:0071353]; positive regulation of macroautophagy [GO:0016239] autophagosome [GO:0005776] phosphatidylinositol-3-phosphate binding [GO:0032266] KDYWDFLCT;VDYKKRERRCPPCSQKGE 2 4.8 0.99021 -0.2735 0 0 0 0 0 0 0 0 8.78218 0 0 0 0 0 0 A0A8I3PWG6 A0A8I3PWG6_CANLF Serine rich and transmembrane domain containing 1 SERTM1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] LFPTSLSTSVDPSSGH;LSLLAFLLLLLII;LSLLAFLLLLLIIALQRLK;SLLAFLLLLLIIALQRL;YVSIFLSLLAFLLLLLI 5 37.4 0.99322 -0.064314 3.29732 0 0 0 5.33117 0 0 0 7.53458 0 0 0 0 5.69279 0 A0A8I3PWH1 A0A8I3PWH1_CANLF Solute carrier family 39 member 2 SLC39A2 Canis lupus familiaris (Dog) (Canis familiaris) cadmium ion transmembrane transport [GO:0070574]; keratinocyte differentiation [GO:0030216] cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] zinc ion transmembrane transporter activity [GO:0005385] KIGCLLALLLLTL;LLLTLGCG;VGNASEDSDSAQMGYPYG 3 11 0.98802 -0.49474 0 0 0 0 0 0 0 0 9.91064 9.41011 0 0 0 0 0 A0A8I3PWH4 A0A8I3PWH4_CANLF COP9 signalosome subunit 7B COPS7B Canis lupus familiaris (Dog) (Canis familiaris) COP9 signalosome assembly [GO:0010387] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] LANVQECIPYSVLL 1 6.7 0.98913 -0.26313 0 9.83308 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWI1 A0A8I3PWI1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FGEGRHFLFYFFA 1 7.5 0.93994 0.059754 0 0 0 0 0 0 0 0 0 0 0 0 6.09104 0 0 A0A8I3PWI5 A0A8I3PWI5_CANLF "Acrosin-binding protein (Acrosin-binding protein, 60 kDa form) (Proacrosin-binding protein sp32)" ACRBP Canis lupus familiaris (Dog) (Canis familiaris) acrosome assembly [GO:0001675]; fertilization [GO:0009566] acrosomal vesicle [GO:0001669] AGLQTDPELKFQSEF 1 2.9 0.94868 0.053909 0 0 0 8.07922 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWI9 A0A8I3PWI9_CANLF Uncharacterized protein WDR13 Canis lupus familiaris (Dog) (Canis familiaris) centriolar satellite [GO:0034451]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] DRMEDFEDDPRALGARG;QSSHPVRSIFCPLM;VFDQHVDEAV 3 8.5 0.98573 -0.43574 0 0 0 5.5477 0 10.4779 0 0 0 0 0 4.63238 0 0 0 A0A8I3PWJ9 A0A8I3PWJ9_CANLF SEC14 and spectrin domain containing 1 SESTD1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878] calcium channel complex [GO:0034704]; intermediate filament cytoskeleton [GO:0045111] "phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]" GVSWSPMDD;SELQQRRFN 2 2.6 1.0034 -1.1109 0 0 0 0 0 5.61035 0 0 0 0 0 0 0 0 0 A0A8I3PWK0 A0A8I3PWK0_CANLF Immunoglobulin superfamily member 10 IGSF10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of neuron migration [GO:2001222] extracellular region [GO:0005576] DYNHIQQVWQVL;ETSTKPSIFAFTHSPLE;FIKYLYLSDNFLN;FPLLPEAMQ;KYTLHENGTLVIKE;LSTMHIQYSSD;NPSLLFENKPNVNI;NTTARPRPIVTQLLKIPGEEI;RPFPSSARRIDPQ 9 4.7 1.0043 -1.0916 9.67342 0 11.2764 10.2369 12.4114 13.2354 8.48418 0 9.22644 9.76507 8.87636 0 10.0272 13.6912 9.23446 A0A8I3PWK2 A0A8I3PWK2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GALVPPSFVTK;GSLPITVTWLKDNDE;LYVVKTSD;PPIKITWFAND;VTTEDSGEYMCEAQNEA 5 10.9 0.98733 -0.3381 0 0 8.16837 0 8.42244 0 0 0 3.05055 6.95093 0 0 0 0 0 A0A8I3PWM2 A0A8I3PWM2_CANLF Ankyrin repeat and sterile alpha motif domain containing 1A ANKS1A Canis lupus familiaris (Dog) (Canis familiaris) AARNGHKAVVQVLLDAGMDSNYQTE;EQNNDNETALHCA;GGGGGGGG;GGGGGGSG;GVHAPGASP;GVHAPGASPPSVLDQASQHPGGAE;TASEVLAM 7 7.9 1.0025 -0.76227 0 0 8.78803 0 8.12138 0 0 9.05607 7.98311 0 0 0 3.78816 0 9.28485 A0A8I3PWN2 A0A8I3PWN2_CANLF Potassium inwardly rectifying channel subfamily J member 13 KCNJ13 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] LTYYHSIIPSSPLAT 1 4.2 0.95691 0.053878 0 0 0 0 0 0 6.60066 0 0 0 0 0 0 0 0 A0A8I3PWN4 A0A8I3PWN4_CANLF Choline transporter-like protein SLC44A2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228] CVFLLLAIVGYVA;FNYLHWVVTSYWYWTLF;GGEAGDGGGG;VIAMLMSLLFIVLLRFLAG 4 8.6 0.99577 -0.56523 0 0 0 0 0 0 0 0 0 0 0 0 8.56381 0 0 A0A8I3PWN7 A0A8I3PWN7_CANLF Uncharacterized protein RPRM Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] VRCCTQAA 1 7.1 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.71273 0 0 0 A0A8I3PWP2 A0A8I3PWP2_CANLF Microfibril associated protein 1 MFAP1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U2-type spliceosomal complex [GO:0005684] RNA binding [GO:0003723] AAGVRDVFER;EEEEEIDDEEIERR;NTDDENDEEEYEAWK;QEAKRMAEER;QKELEQEA 5 12.3 1.0031 -1.1145 0 0 0 14.4061 0 0 0 0 0 0 0 0 14.2423 5.19908 0 A0A8I3PWP6 A0A8I3PWP6_CANLF Keratin 82 KRT82 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] ESELCSLQDALE;VGSGEVYI;VLSPGVLKSSGGCSVV;VLYEPCTVSTPVLSPG 4 9 0.9439 0.084093 0 13.1017 0 0 0 0 0 10.4574 13.3919 10.3287 11.1544 0 13.2663 0 0 A0A8I3PWP8 A0A8I3PWP8_CANLF N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A) NTMT1 Canis lupus familiaris (Dog) (Canis familiaris) methyltransferase activity [GO:0008168] GIGRITKRLLLPLFGVVD;LGGYGHIS;VILDDVDSSVCRD 3 17.5 1.0025 -0.7265 0 0 0 12.594 4.87563 0 0 0 0 0 0 0 0 0 0 A0A8I3PWR3 A0A8I3PWR3_CANLF Component of oligomeric golgi complex 5 COG5 Canis lupus familiaris (Dog) (Canis familiaris) "glycosylation [GO:0070085]; Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" Golgi transport complex [GO:0017119]; nucleoplasm [GO:0005654] DECYSDFLNEDFDVKTY;FQRAEWSHARFSQ;GAAAATVRELLQDECYSDFLNEDF;TTDLYVDLQQMDD;VHQPSAPPNSVL 5 6.7 0.93801 0.06475 0 11.458 0 0 0 4.9521 0 8.8662 0 0 0 0 0 10.2563 9.77228 A0A8I3PWR7 A0A8I3PWR7_CANLF G protein-coupled receptor class C group 5 member A GPRC5A Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; plasma membrane [GO:0005886]; vesicle [GO:0031982] G protein-coupled receptor activity [GO:0004930] LLTKQRNPMDYPV;VGAVTSMAFMFAL;WKRHGTHIFL 3 10.1 0.98662 -0.45814 0 8.97679 0 0 0 0 9.71125 7.6401 0 0 0 0 0 0 0 A0A8I3PWS4 A0A8I3PWS4_CANLF TGF-beta-induced transcription factor 2-like protein TGIF2LX Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EETPAGNQSLTEGT;RMLSEQTNLSFLQISN 2 12.8 0.9852 -0.44823 0 0 0 0 0 0 0 0 10.6684 0 0 0 0 0 0 A0A8I3PWT2 A0A8I3PWT2_CANLF Uncharacterized protein NEURL3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HDGIVFSQRPVRPG;LLLRKGVL;RKGVLMGAPLWAV 3 11.2 1.0018 -1.2939 7.39077 0 10.2832 0 0 0 0 0 12.7756 0 0 0 0 0 0 A0A8I3PWU1 A0A8I3PWU1_CANLF Transient receptor potential cation channel subfamily C member 4 TRPC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium channel activity [GO:0005262] LNPRESWDMWHPTL;RAESELSPSEKAYLNAVEK;YYKRNVNA 3 5.1 1.0018 -0.99351 0 0 0 7.29407 0 0 0 0 0 8.72792 0 3.49697 6.5027 0 0 A0A8I3PWW8 A0A8I3PWW8_CANLF Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) HACD3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid elongation [GO:0030497]; JNK cascade [GO:0007254]; negative regulation of intracellular signal transduction [GO:1902532]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rho protein signal transduction [GO:0007266]; very long-chain fatty acid biosynthetic process [GO:0042761] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] enzyme binding [GO:0019899]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158] ENQVLTPHVYWAQRHRELY;FHLEFLDLVKPEP;GLYINFRHLYKQRRRRFGQKKKKI;LSCIDMDWKVLTW 4 19.1 0.99744 -0.10231 0 0 5.26416 0 0 3.97021 0 7.99921 0 9.56148 0 0 9.95526 3.74524 0 A0A8I3PWX1 A0A8I3PWX1_CANLF Sorting nexin 31 SNX31 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] phosphatidylinositol binding [GO:0035091] EDCKVGLRKWY;SRWAGRRSATGRGGGS;WYMDPSLDSVLMDS 3 8.6 0.99373 -0.17224 0 0 0 0 0 0 10.6935 0 0 0 0 0 0 0 0 A0A8I3PWX8 A0A8I3PWX8_CANLF Neural cell adhesion molecule 2 NCAM2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] EVKGQHGSSSLHIK;FIEENEKY;GYEVQITAANR;NETTPLTEPEKLPLKEENG;TAKVSFNKPDSHGGV;VLSNLEPNTTYEIRVAAV;VTDVSCFFIRQCG 7 11.8 1.0044 -1.0946 0 10.8365 7.87891 8.87477 9.39311 0 0 7.16531 0 0 0 0 6.56337 0 7.05875 A0A8I3PWZ2 A0A8I3PWZ2_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO1 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] EVILPVPA;KSPDDPSRYITPDQLAD;VYHNLKNVI 3 7.8 1.0035 -1.7005 0 0 8.1871 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PWZ5 A0A8I3PWZ5_CANLF TGFB induced factor homeobox 2 TGIF2 Canis lupus familiaris (Dog) (Canis familiaris) amacrine cell differentiation [GO:0035881]; nodal signaling pathway [GO:0038092]; positive regulation of amacrine cell differentiation [GO:1902871]; regulation of gastrulation [GO:0010470] centrosome [GO:0005813]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AEMELQKQQDPS 1 5.1 0.99116 -0.20939 0 0 0 0 0 0 0 0 9.98911 0 0 0 0 0 0 A0A8I3PX00 A0A8I3PX00_CANLF Signal transducer and activator of transcription STAT1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ACIGGPPNACL;EERKILENAQ;HDLLSQLDDQYS;ISVSEVHPSRLQ;LVLKTGVQFTVKLRLLVKL;NMLVTEPRNLSFFLNPPCARWSQL;TVKLRLLVKLQ;VLKTGVQFTVKLRLLVKLQELN;VTFPDIIRNY 9 13.6 0.99273 -0.55504 0 0 11.263 0 4.72928 0 0 0 0 0 6.58525 0 0 13.1931 5.69404 A0A8I3PX06 A0A8I3PX06_CANLF Potassium channel tetramerization domain containing 12 KCTD12 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] identical protein binding [GO:0042802] EDKIWTSYTESIYGACCF;GGGGGGSG;RSPSGGAAGPL 3 10.6 0.98234 -0.24828 0 0 0 4.74846 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PX17 A0A8I3PX17_CANLF BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) BABAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; hematopoietic stem cell proliferation [GO:0071425]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytosol [GO:0005829]; nuclear body [GO:0016604] ETASCSTFNLE;IAWLSGLTSDPRE;PNPPGAGP;PNSPTEEEEEEEEEEEEE;TEEEEEEEEEEEEEEEQSAEPR 5 17.3 1.0032 -1.5721 0 0 7.13597 0 0 0 0 8.66956 10.9057 0 3.55974 0 0 0 0 A0A8I3PX29 A0A8I3PX29_CANLF Proteasome subunit alpha type Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" IPIQRYGRRPY;VGLKSKTHAVL 2 8.4 0.9863 -0.41672 0 16.8663 0 0 16.8463 0 14.8215 14.678 0 0 0 0 16.4909 0 16.4082 A0A8I3PX43 A0A8I3PX43_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP44 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; chromosome segregation [GO:0007059]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulatory T cell differentiation [GO:0045066] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] VSPFAMLH;VYQMNECQE 2 2.4 1.0037 -0.80421 0 9.40542 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PX65 A0A8I3PX65_CANLF endothelin-converting enzyme 1 (EC 3.4.24.71) ECE2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] Golgi apparatus [GO:0005794]; transport vesicle membrane [GO:0030658] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DSKSSNSNVIQVDQ;GGGGNVGF;GVSPCEDFY;TFNSTSEAERKTQ;WNITGPWDQDNFME 5 7.9 1.0026 -1.7452 12.95 13.2208 0 0 0 7.72349 0 0 0 12.9877 0 13.1503 6.93404 0 13.2572 A0A8I3PX66 A0A8I3PX66_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of sodium ion transport [GO:0010766]; positive regulation of potassium ion import across plasma membrane [GO:1903288] cytosol [GO:0005829] ATP binding [GO:0005524]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674] DLEAAFLSRDVDDGSGSP;ELRRLREKHLKEIQ;FQVSVAMDDVQK;GVSVAAPQSAPPEPP;HYRKSVRSRSRHEKTSRPKLRI;IPVSTALASAVGSV;NTVGGTVN;PESQIFFPTIHE;PPPTGGAA;SGSTVSSIGTLPS;VAAQPSVVPVHSGAHFLPVGQ 11 5.8 0.98822 -0.34164 6.92932 7.99707 0 0 0 10.7912 8.97215 6.62743 10.4109 0 4.37858 0 5.86693 9.2774 0 A0A8I3PX71 A0A8I3PX71_CANLF Inhibitor of nuclear factor kappa B kinase subunit epsilon IKBKE Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of gene expression [GO:0010628] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EMMLRGLHWFVETLQATCR;EYCSSGSLLSVLESP;FVSVYGTE;KLNHQNIVKLFAV;QRLQDRTKE 5 9.8 1.0002 -0.61646 0 5.95599 0 0 0 0 0 0 8.48864 0 0 0 0 0 8.83864 A0A8I3PX72 A0A8I3PX72_CANLF Zinc finger protein 449 ZNF449 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357]; spermatogonial cell division [GO:0007284] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EEETYKCLECGKS 1 2.5 0.98992 -0.27352 0 0 0 8.00107 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PX73 A0A8I3PX73_CANLF nucleoside-diphosphate kinase (EC 2.7.4.6) Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] nucleoside diphosphate kinase activity [GO:0004550] GTIRGDFSVHISRN;GVGHHCVV 2 12.8 0.98876 -0.2623 0 0 0 0 0 0 8.87716 0 0 0 0 0 0 0 0 A0A8I3PX78 A0A8I3PX78_CANLF Small ribosomal subunit protein mS38 AURKAIP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of proteolysis [GO:0045862] mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654] KVREGRLRRKQIKFERDLRRIWLKA;LKIRRRKMNHHKYRKLVKRT;LVKRTRFLRRKVR;YRKLVKRTRFLRRKVREGRLRR 4 25.3 0.85833 0.19 0 4.09862 0 0 0 0 0 6.12679 9.93612 0 0 0 0 0 0 A0A8I3PX84 A0A8I3PX84_CANLF Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to mechanical stimulus [GO:0071260] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270] ACAKPPWNAEKHSNHL;DLAEPWIQVF;EECRRNREPLI;GLHKMDDRPEERMI;HTKAKQPYREDTEWLKGQQIG;MSASQDALPIVPQLQVENGE;SVGLPSSTMEQ;TSQLSISTLL;TYVRNTSSEQEEVVE;VGCAIIEMACAKP;VGCAIIEMACAKPPWNAE;WLERRNRRGPVVVKPIPTK;WQELLGRLC 13 10.9 1.0025 -1.7935 13.88 14.0632 0 0 0 6.75302 7.94726 13.5752 9.76668 0 4.31223 0 9.71983 0 0 A0A8I3PX90 A0A8I3PX90_CANLF "Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (Telokin)" MYLK Canis lupus familiaris (Dog) (Canis familiaris) aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of wound healing [GO:0090303] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; myosin light chain kinase activity [GO:0004687] DTGTYTCE;EPQVTWHRNG;GDGGGGGG;GDGGGGGGMG;GVAELHIQDALPEDDGIYT;IEKALPEDRGFYK;IQEVFPEDTGTYTCEAWNS;ISNAKPAE;LDLKPENIMCVNKTG;LVKRLAVMEVAP;RAIGRLSSMAMI;SGLSPFMGDNDNETLA;VIHAVREEDQGKYT;VINYEPIGY;VLKDCAVIEGQDFVLQCSVQG;WTLLVKRL 16 8.7 0.9969 -4.1829 0 9.98028 0 0 6.34332 0 10.1087 11.1999 10.8383 0 10.5202 9.08624 10.0037 6.73037 9.81301 A0A8I3PX91 A0A8I3PX91_CANLF procollagen galactosyltransferase (EC 2.4.1.50) COLGALT1 Canis lupus familiaris (Dog) (Canis familiaris) procollagen galactosyltransferase activity [GO:0050211] ECRLVEAVDGKAMNTSQV;EPLLIYPT;RRWRPRPVLLLLLLLALPPPG 3 7.9 0.99056 -0.21126 0 0 0 0 0 0 8.42089 0 0 0 0 0 6.07878 0 0 A0A8I3PX98 A0A8I3PX98_CANLF LDL receptor related protein 4 LRP4 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta clearance by cellular catabolic process [GO:0150094]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; enzyme-linked receptor protein signaling pathway [GO:0007167]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; proximal/distal pattern formation [GO:0009954]; receptor-mediated endocytosis [GO:0006898]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synaptic assembly at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; neuromuscular junction [GO:0031594]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; coreceptor activity [GO:0015026]; hormone binding [GO:0042562]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971] AEHWYCDGDTDC;ANLNGSNVEE;APPCNLEEFQCAY;AQWQCDGDNDCGDHSDEDGCM;ASPKIERAGMDASSRQV;CDGDADCD;CDGDDDCGDWS;CDGDDDCGDWSDES;CDGDDDCGDWSDESD;CDGDDDCGDWSDESDCS;CDGDDDCGDWSDESDCSSHQ;CDGDDDCGDWSDESDCSSHQPC;CDGDNDCEDD;CDGDNDCEDDS;CDGDNDCEDDSDE;CDGDNDCEDDSDEQDC;CDGDNDCGDNSDEQC;CDGDNDCGDNSDEQCDMR;CDGEDDCAD;DDCADNSDEENCEN;DDCGDWSDESDC;EQDCPPRECEEDEFPCQNGYC;ESDCSSHQPCRSGEFMCDSGL;GDDDCGDWSDESDCSS;GDDDCGDWSDESDCSSH;GDNDCEDDSDEQDC;GSMRKVLVWENLDSP;GVNDCGDNSDES;GVVPPAPK;HCDGDDDCGDWSD;HCDGDDDCGDWSDESDCSSHQ;HCDGDDDCGDWSDESDCSSHQP;IDYAGHRMYW;PFALTQQDRW;QWQCDGDNDCGDHSDE;RCDGEDDCADNSD;RLSWRCDGEDDCADNSDEENC;SLWHCDGDNDCGDNSDEQCD;SWVCDGDNDCEDDSDEQ;VIPLADVRSAVALDW;WQCDGDNDCGD;WQCDGDNDCGDHSDEDGCMLP;WVCDGDNDCEDDSDEQDCPPRECEE;WVDAHLDRIE;YHCDGDDDCGDWSDESDCS 45 14.6 0.99686 -4.1859 10.4229 13.4919 13.4413 9.38351 10.1021 9.5273 10.5193 13.1495 10.9385 10.5159 9.48611 8.85247 9.65575 9.67303 9.74239 A0A8I3PXA2 A0A8I3PXA2_CANLF IF rod domain-containing protein KRT83 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] CITAAPYRGISCYRGL;LEPLFEGYIETL 2 5.7 0.95629 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.51161 A0A8I3PXA3 A0A8I3PXA3_CANLF Serine/arginine repetitive matrix 4 SRRM4 Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; sensory perception of sound [GO:0007605]" nucleus [GO:0005634] identical protein binding [GO:0042802]; mRNA binding [GO:0003729] EALGTNSWERDKACRE;LTGQSKTAGE 2 4.1 0.99434 -0.56222 7.58519 0 0 0 0 0 8.38853 0 0 0 0 0 0 8.36968 0 A0A8I3PXC0 A0A8I3PXC0_CANLF Protein NDRG3 (N-myc downstream-regulated gene 3 protein) NDRG3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] LSTEPVPSASMTRLARS 1 4.4 0.9788 0.046227 0 0 0 4.3059 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PXC2 A0A8I3PXC2_CANLF G-protein coupled receptors family 1 profile domain-containing protein OXER1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] ALNRYLKVVWPH 1 3 0.9921 -0.27838 0 0 10.9731 0 6.6038 0 0 0 0 0 0 0 0 0 0 A0A8I3PXD7 A0A8I3PXD7_CANLF Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) HVCN1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated proton channel activity [GO:0030171] GDDYHAWNVNYKK;LFQKHEFE;LLILLRLWRVARI;YHAWNVNYKKWENEEDDEEEEQP 4 17.5 0.99407 -0.057544 0 0 0 0 0 0 5.48049 0 0 0 0 0 11.8182 0 6.8658 A0A8I3PXD8 A0A8I3PXD8_CANLF Ras-related protein Rab-2A (EC 3.6.5.2) LOC100683203 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] acrosomal vesicle [GO:0001669]; autophagosome membrane [GO:0000421]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LESRREVNKEEG;TSAKTASN 2 9.4 1.0041 -1.0539 8.63543 8.40041 0 0 0 0 0 8.61589 8.62957 0 0 0 0 0 9.05837 A0A8I3PXE2 A0A8I3PXE2_CANLF Glutamate decarboxylase 1 (EC 4.1.1.15) GAD1 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid biosynthetic process [GO:0009449] cytoplasm [GO:0005737]; presynaptic active zone [GO:0048786] glutamate decarboxylase activity [GO:0004351]; pyridoxal phosphate binding [GO:0030170] EQILVDCRDTLKYGVRTG;FENQINKCLELAEYLYAK;GVRTGHPRFFNQ;VKEKGILQGCNQMCAGYLFQPDKQY 4 11.6 0.99425 -0.1289 0 0 7.23793 0 9.83618 0 0 0 10.276 0 0 0 0 0 0 A0A8I3PXE5 A0A8I3PXE5_CANLF T cell receptor associated transmembrane adaptor 1 TRAT1 Canis lupus familiaris (Dog) (Canis familiaris) EPVDENCYEQMKAR 1 9.3 0.93263 0.060775 0 0 0 4.89356 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PXF2 A0A8I3PXF2_CANLF Vomeronasal type-1 receptor LOC106560070 Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] ITLSPRSSY;SFIDVKNASFSEIGI 2 7.8 0.98222 -0.2483 0 0 0 0 0 0 0 0 0 0 0 0 7.84543 0 0 A0A8I3PXF7 A0A8I3PXF7_CANLF Odontogenesis associated phosphoprotein ODAPH Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of enamel mineralization [GO:0070175] DNGGATDCQVFTLTP 1 8.6 0.95402 0.053902 0 0 0 0 0 0 0 0 0 0 0 7.09244 0 0 0 A0A8I3PXG1 A0A8I3PXG1_CANLF Transmembrane protein 40 TMEM40 Canis lupus familiaris (Dog) (Canis familiaris) QEQPKRHKSSTSSSSSSSSSSS 1 10.9 0.9757 0.046904 0 0 5.24857 0 0 0 0 0 0 0 0 6.33455 0 0 0 A0A8I3PXG9 A0A8I3PXG9_CANLF Carbonic anhydrase (EC 4.2.1.1) CA6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] LAALVKEQQWSLT 1 4.3 0.99727 -0.1028 0 0 0 0 0 0 0 0 11.9158 9.24341 0 0 0 0 0 A0A8I3PXH3 A0A8I3PXH3_CANLF Adenine DNA glycosylase (EC 3.2.2.31) MUTYH Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; negative regulation of necroptotic process [GO:0060546] nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; MutSalpha complex binding [GO:0032407]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]" ETQPEWSYLS;NWYDREKRDLP;TLQDLAGASLEE;TRRAARRAAGGTRHFRLRSPR 4 8.5 0.97698 0.047166 0 0 0 0 0 0 0 0 0 0 8.11286 0 0 0 0 A0A8I3PXI6 A0A8I3PXI6_CANLF MORC family CW-type zinc finger 3 MORC3 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cellular senescence [GO:2000774]; post-embryonic development [GO:0009791]; protein stabilization [GO:0050821] chromatin [GO:0000785]; PML body [GO:0016605] ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; protein-macromolecule adaptor activity [GO:0030674]; zinc ion binding [GO:0008270] EDIQKRPDQTW;IAPESDYSLRAYCSILYLKPRMQ;LLAMIVPD;LVTQEKENY;MVVQLDDVFRQLDKCTVERDQYK;SATEFDFDKDK;STETDAVFLLESING;VHPTYEKTYKKKDK 8 12.1 1.0032 -2.3599 8.791 9.58073 0 0 13.5258 0 10.5136 0 0 10.8414 0 0 0 5.19566 6.7021 A0A8I3PXJ5 A0A8I3PXJ5_CANLF DNA helicase (EC 3.6.4.12) CHD7 Canis lupus familiaris (Dog) (Canis familiaris) adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; cognition [GO:0050890]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; in utero embryonic development [GO:0001701]; innervation [GO:0060384]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AEVTKAFEE;EADVWIPEPFHA;EGLKMMDLEHKV;ELDIDALNGRNNLV;EPVTHYLVKWCSLPYEDST;HNADSPDFQLQAM;KEDALNLSVPRQRRRRRRKI;KYKNFSYLH;LEENPEFAVAP;LITAYQRSY;LSVPRQRRRRRRKI;QAMIQAAGKLVLIDKLL;QEVIGDQADKILEGA;RDETRDGFYMEDGDPS;RENATNGV;SVPRQRRRRRRKIE;VPRQRRRRRRKIEI 17 6.1 0.95062 0.058308 0 10.5783 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PXJ9 A0A8I3PXJ9_CANLF Vestigial like family member 3 VGLL3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DLVPSVGFETGL;EDEDEEEE;KQEEEEDEDEEEEEEE;QEEEEDEDEEEEEEEK;SKQEEEEDEDEEEEEEEKD;SVGFETGLQHQDKNK;TTVTTATSAWAGAFH 7 16.1 0.98571 -0.44224 0 0 0 0 0 0 0 0 8.63949 0 3.90814 0 0 0 12.9363 A0A8I3PXK3 A0A8I3PXK3_CANLF Collagen alpha-4(VI) chain-like LOC610614 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] serine-type endopeptidase inhibitor activity [GO:0004867] AADVLVEENR;ATLELSALDI;EKNGYGAERNR;GNSGHKGL;GVDGLVGEQGNRGAPGS;GVKVMSVGVQDFD;GVPGPPGPVGAKGKV;ITDDVQKVYYE;LEDLEVAAQPGVSPHGSR;LSVGIDISTSTRQ;NIENFNILQDFSG;QGEEGCPG;QQVCDTLAKAAQPVDSVF;VFVEERGSRSKQ;VYVVGVNVQDVQELQ 15 8.2 1.0023 -2.585 11.862 9.27153 0 5.77363 4.18309 7.88246 0 7.99373 9.85507 6.90809 0 0 8.54686 10.4011 6.18573 A0A8I3PXK5 A0A8I3PXK5_CANLF Zinc finger protein 518A ZNF518A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HIHRHNEIHYKC;KDERPHCE;LILKRYRIDASRKTFWKRKK 3 2.7 0.98633 -0.41135 0 5.08589 0 0 0 0 0 0 0 0 0 4.76591 0 0 0 A0A8I3PXK7 A0A8I3PXK7_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP16 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213] endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635] kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+- protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+- protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; protein serine/threonine kinase activator activity [GO:0043539] ADASKLPNLNELLQSSG;TVMLSLYLLLLLIVSA 2 10.2 0.96056 0.049233 0 0 0 0 0 0 0 0 0 0 6.39886 0 0 0 0 A0A8I3PXL0 A0A8I3PXL0_CANLF Interleukin 23 receptor IL23R Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of interleukin-10 production [GO:0032693]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of type II interferon production [GO:0032729]; response to lipopolysaccharide [GO:0032496]; response to type II interferon [GO:0034341] interleukin-23 receptor complex [GO:0072536] interleukin-12 receptor binding [GO:0005143]; interleukin-23 binding [GO:0042019]; interleukin-23 receptor activity [GO:0042020] EDIPNMENSKVV;IKRRILLLIPKW;LGIMNEELPSI;QISNFLTGGNH;WVEPATIFKMGMN 5 9.4 0.98751 -0.40251 0 0 0 0 0 0 0 0 11.9497 0 3.58484 0 0 0 9.20753 A0A8I3PXM2 A0A8I3PXM2_CANLF Ankyrin repeat domain 65 ANKRD65 Canis lupus familiaris (Dog) (Canis familiaris) protein localization to ciliary inversin compartment [GO:1904108] ciliary inversin compartment [GO:0097543] GEQELRWVELGSEEALGA;GSLRVAELLLRRGALA;PLVRLLLQRGAAVGAADH;VGAADHAGRTPLHEAAWHGS 4 16.1 0.99271 -0.067346 0 0 0 3.89627 0 0 7.20222 0 9.0281 0 0 3.45536 0 0 0 A0A8I3PXM3 A0A8I3PXM3_CANLF Protein TEX261 TEX261 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] COPII-coated ER to Golgi transport vesicle [GO:0030134]; membrane [GO:0016020] COPII receptor activity [GO:0097020] HVLAWAQAGRV;HVLAWAQAGRVLPWAH;PGGGAGGG 3 5.9 0.99242 -0.16576 0 0 0 0 0 13.4551 0 0 8.58365 0 0 0 0 0 0 A0A8I3PXN5 A0A8I3PXN5_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] non-membrane spanning protein tyrosine phosphatase activity [GO:0004726] RTLTWLPSSSLL 1 4.7 0.94839 0.05044 0 0 0 0 0 0 0 0 0 15.3768 0 0 0 0 0 A0A8I3PXN7 A0A8I3PXN7_CANLF Coiled-coil domain containing 34 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAGTCGGG;PQSPAARTRRHG;VGKEKEERDRLQ 3 5 1.0025 -1.0035 0 11.314 10.8881 0 0 0 0 0 0 0 0 0 0 7.41287 0 A0A8I3PXN9 A0A8I3PXN9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] VAYINSGGSSTYYADAVKGQFTISR;VRQAPGKGLQ 2 43.8 0.97892 0.035538 0 0 0 0 0 0 0 0 0 6.19574 0 0 0 0 0 A0A8I3PXP3 A0A8I3PXP3_CANLF Nuclear receptor subfamily 4 group A member 2 NR4A2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; central nervous system neuron differentiation [GO:0021953]; dopaminergic neuron differentiation [GO:0071542] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270] CLLLHCCPGYGHR 1 2.6 0.93845 0.059745 0 0 0 0 0 0 0 0 0 0 0 0 0 8.08868 0 A0A8I3PXQ4 A0A8I3PXQ4_CANLF GCF C-terminal domain-containing protein PAXBP1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]" nucleus [GO:0005634] DNA binding [GO:0003677] EKSKIKTELN;ESAIHQLYKQ;IDCIKSQFEAWRSKYYLSYKDAY;VLESFYSIDCIKSQFEAWRSKY 4 5.4 1.0021 -1.1362 0 0 0 0 9.97499 0 12.8832 0 0 0 0 0 0 0 0 A0A8I3PXQ9 A0A8I3PXQ9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESGGDLVKPG;ESGGDLVKPGG;ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;RQAPRKGLQ;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG 26 29.3 1.0038 -0.80421 0 9.11158 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PXT3 A0A8I3PXT3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] blood microparticle [GO:0072562]; immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] EVQLVESG;EVQLVESGG;EVQLVESGGNLVKP;EVQLVESGGNLVKPG;EVQLVESGGNLVKPGG;QGEVQLVESGGNLVKPGG 6 13.5 0 10.906 12.4313 12.9588 12.6286 11.5001 11.745 11.6376 13.1037 12.7588 12.8487 12.1063 12.0175 12.2231 12.1433 12.1808 12.0272 A0A8I3PXT5 A0A8I3PXT5_CANLF MKRN2 opposite strand MKRN2OS Canis lupus familiaris (Dog) (Canis familiaris) DLHVGITNTNGIVY;KYLEDFSSTGAWLPQRYQ;TQGTFLREYDGRSDL 3 20.2 0.98622 -0.4258 0 0 0 0 7.88716 0 11.1438 0 0 0 0 0 9.49051 0 0 A0A8I3PXT7 A0A8I3PXT7_CANLF SH2 domain-containing protein 1A SH2D1A Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; humoral immune response [GO:0006959]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954] cytoplasm [GO:0005737] ATGLDGSY;LDGSYLLRDSESVPG 2 14.1 1.0021 -1.2784 0 11.1346 0 0 0 0 10.3209 11.3354 0 0 0 0 0 0 0 A0A8I3PXT9 A0A8I3PXT9_CANLF Calcium voltage-gated channel auxiliary subunit gamma 5 CACNG5 Canis lupus familiaris (Dog) (Canis familiaris) "neurotransmitter receptor internalization [GO:0099590]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; transmission of nerve impulse [GO:0019226]" AMPA glutamate receptor complex [GO:0032281]; postsynaptic density membrane [GO:0098839] channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245] EERGRCFTIEYV;FMFIGFIL 2 7.3 0.98977 -0.21512 9.45376 0 0 0 0 0 0 10.3346 0 0 0 0 0 0 0 A0A8I3PXU9 A0A8I3PXU9_CANLF NEDD1 gamma-tubulin ring complex targeting factor NEDD1 Canis lupus familiaris (Dog) (Canis familiaris) KAPASGIC 1 1.2 0.99027 -0.26592 0 0 0 0 0 0 0 0 8.45142 0 0 0 0 0 0 A0A8I3PXV0 A0A8I3PXV0_CANLF Semaphorin 3A SEMA3A Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] semaphorin receptor binding [GO:0030215] EVIDTEHLEELLHKDDDGDGSKTK;FFFRENAID;KETWHDLEEVLLEEMTVFREPT;RLYVGAKDHI 4 8.9 1.0017 -1.4088 0 0 0 0 0 0 13.1934 0 0 0 10.0013 0 6.04142 0 0 A0A8I3PXV2 A0A8I3PXV2_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of receptor catabolic process [GO:2000646]; regulation of endocytosis [GO:0030100]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of intracellular protein transport [GO:0033157] cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; early endosome [GO:0005769]; endosome lumen [GO:0031904]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sorting endosome [GO:0097443] ephrin receptor binding [GO:0046875]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; zinc ion binding [GO:0008270] PSSLRTKTETGTE 1 3.3 0.93506 0.065262 0 0 0 0 0 0 6.89373 0 0 0 0 0 0 0 0 A0A8I3PXV7 A0A8I3PXV7_CANLF Cilia and flagella associated protein 210 CFAP210 Canis lupus familiaris (Dog) (Canis familiaris) axonemal B tubule inner sheath [GO:0160112] ESRKLFFEH;SRKLFFEHMNDKNII;VIELESESTNKY 3 5.3 0.9925 -0.19316 0 0 0 3.06134 0 0 9.19118 8.51013 0 0 0 0 0 0 8.30323 A0A8I3PXW0 A0A8I3PXW0_CANLF FAU ubiquitin like and ribosomal protein S30 fusion FAU Canis lupus familiaris (Dog) (Canis familiaris) modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein tag activity [GO:0031386]; ubiquitin protein ligase binding [GO:0031625] EKEEEDRPS 1 10.2 1.0037 -0.80421 7.47395 0 0 0 0 0 0 7.37086 7.16732 0 0 0 0 0 0 A0A8I3PXX0 A0A8I3PXX0_CANLF Uncharacterized protein LOC102152005 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MKVLISLGGIIP 1 4.4 0.98962 -0.27359 0 0 0 0 0 0 8.24603 0 0 0 0 0 0 0 0 A0A8I3PXX6 A0A8I3PXX6_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) MST1R Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; response to virus [GO:0009615] plasma membrane [GO:0005886]; stress fiber [GO:0001725]; vacuole [GO:0005773] ATP binding [GO:0005524]; enzyme binding [GO:0019899]; protein tyrosine kinase activity [GO:0004713] DSTTWGHKASSSDSGDGS;GFSFMEPV;GVLLALLVLVAVLA;GVLLALLVLVAVLATVLIFNYRRR;LLLLLLLL;LLLLLLLLL;LLLLLLLLP;LLLLLLLP;NVTVAHMGTAD;PSRERVPQRLLLGVLLALLV;PVLTAVKPHFGPRAGGTRLTLEGKG;RLLLGVLLALLVLVAVLATVLI;RVPQRLLLGVLLALLVL;SQPSLLLLLLLLLP;SVTAAPGALHT;VGGAVVPG 16 9.7 1.0029 -1.5844 9.88676 7.84844 4.10526 0 5.27098 5.63935 5.61073 13.8739 0 0 4.82523 0 9.24911 9.55656 4.32517 A0A8I3PXX9 A0A8I3PXX9_CANLF catechol O-methyltransferase (EC 2.1.1.6) COMT Canis lupus familiaris (Dog) (Canis familiaris) catecholamine metabolic process [GO:0006584]; methylation [GO:0032259] O-methyltransferase activity [GO:0008171] PARPGGCPSGAPAGPAGTAR;TVLLADNVICP 2 7.5 0.98431 -0.24729 0 0 0 0 0 0 0 9.36951 0 0 0 0 0 0 0 A0A8I3PXY2 A0A8I3PXY2_CANLF Interactor of HORMAD1 1 IHO1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283] condensed nuclear chromosome [GO:0000794] HSSLSDSQFLFG;IKNTCQKCQGVFP 2 4.2 0.98674 -0.23352 0 0 0 0 0 0 0 0 9.44512 0 0 0 0 0 0 A0A8I3PXZ4 A0A8I3PXZ4_CANLF "Voltage-dependent calcium channel gamma-1 subunit (Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma)" CACNG1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of localization in cell [GO:0051649]; sarcoplasmic reticulum calcium ion transport [GO:0070296] sarcolemma [GO:0042383]; voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] AAIAVFSLGFIIMG 1 6.2 0.93553 0.06094 0 0 0 0 0 0 0 0 0 0 4.0798 0 0 0 0 A0A8I3PY06 A0A8I3PY06_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial intermembrane space [GO:0005758] EATITMKTISL 1 13.1 0.98995 -0.20106 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6095 0 A0A8I3PY11 A0A8I3PY11_CANLF Abhydrolase domain containing 18 ABHD18 Canis lupus familiaris (Dog) (Canis familiaris) LYRRLLLTKLFI;YEEEIIHMLE 2 4.7 0.99041 -0.26744 0 0 0 0 0 0 6.52088 0 0 0 0 0 0 0 0 A0A8I3PY23 A0A8I3PY23_CANLF FERM domain containing 5 FRMD5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334] adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; membrane [GO:0016020] cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901] EGKTFYLYVSQKEE;FYPADPAA;LLFVLLLLLI;RLLLVTMGLLFVLLLLLIILT;SSNLFFKGSRFRY;VLRLLLVTMGLLFVLLLLLII 6 10.2 1.0016 -0.95386 0 0 0 0 8.51909 10.4323 9.8631 0 0 0 0 0 0 7.46508 3.66369 A0A8I3PY52 A0A8I3PY52_CANLF Putative nuclease HARBI1 (Harbinger transposase-derived nuclease) HARBI1 Canis lupus familiaris (Dog) (Canis familiaris) centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; nuclease activity [GO:0004518] DSSFFLRTWLMTPLHIPETPAEYRY;EQPPEEEFEHME;LYGRGHRTLDRFKLD 3 14.9 0.98795 -0.49578 10.6966 0 0 0 0 0 0 0 0 0 11.6525 0 6.21607 6.69919 0 A0A8I3PY55 A0A8I3PY55_CANLF "SET domain containing 1B, histone lysine methyltransferase" SETD1B Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; Set1C/COMPASS complex [GO:0048188] histone H3K4 methyltransferase activity [GO:0042800]; RNA binding [GO:0003723] DDDDDDEDSEDQD;DDDDEDSEDQDES;DDDDEDSEDQDESENDDEDV;DDDEDSEDQDESENDDEDVAL;DEGQQSSGEDMEISDDEMPSA;DKDDDDDDDEDSEDQ;EEEEAAADESMAPVV;EFRRAPVPPPLPPTEPL;ESSESSEFESSSESSSSSSEDEE;ISSSSSQLSPLAPFGTNSQ;KDDDDDDDEDSE;KGETRMRFYELLVTGRYTP;LFAMEPIAAD;PISSSSSQLSPL;SEAIPPGP;SSESSEFESSSESSSSSSE;SSESSESSEFESSSESSSSSSE;STEEEEEGEEEE;TDEPPADTQGMSIPAQP;TGLPLPLPLPLPLPLALPV;VEELASCKEPPEE;VMQVDMSHVLGGQWGGMPMSFQMQ 22 12.6 0.93892 0.10431 0 0 6.05702 4.36653 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PY63 A0A8I3PY63_CANLF SV2 related protein SVOP Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle membrane [GO:0030672] transmembrane transporter activity [GO:0022857] FRRTGESARSEDDTASGE;LSWSLRLWDAGSWWSQLGHR;RDQRPRTAR;SVLTGLAWMA 4 10.2 1.0033 -0.83536 8.88926 0 0 0 0 0 0 6.0358 0 0 0 0 9.3413 0 0 A0A8I3PY69 A0A8I3PY69_CANLF Regulatory factor X1 RFX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGG;GGGGGGSG;KDEEEEEEEESEDEL;PQAQPPGSQKQYVT;VFEPLPGL 5 4.6 1.0032 -1.6238 8.24322 0 0 0 0 6.25287 0 0 0 0 0 0 9.02048 0 0 A0A8I3PY78 A0A8I3PY78_CANLF MINDY family member 4B MINDY4B Canis lupus familiaris (Dog) (Canis familiaris) protein K48-linked deubiquitination [GO:0071108] cysteine-type deubiquitinase activity [GO:0004843]; K48-linked deubiquitinase activity [GO:1990380] ELVEKEATEKFIY;VHLTVDTHSH 2 5 1.0024 -0.76715 0 0 9.60544 0 0 0 0 12.0251 0 0 0 0 0 0 0 A0A8I3PY96 A0A8I3PY96_CANLF "Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial)" Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; ribosome [GO:0005840] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] PASPPPGRRRKAW 1 3.1 0.94375 0.059642 0 0 0 0 2.57318 0 0 0 0 0 0 0 0 0 0 A0A8I3PYA6 A0A8I3PYA6_CANLF Synaptonemal complex protein 1 SYCP1 Canis lupus familiaris (Dog) (Canis familiaris) synaptonemal complex assembly [GO:0007130] synaptonemal complex [GO:0000795] EKLKTTEL;EQHYSKQVKELKTELENEKL;LQENRKIIEAQRKAIQELQ;MIIAFEELRVQAENSRLEMHFKLKE;NENLKESNEKQNHLISELED;TKKYEYEREETRQVYV 6 11 1.0018 -0.91391 0 0 8.06674 0 0 8.09924 10.3813 0 0 0 11.3929 0 0 0 9.97885 A0A8I3PYA9 A0A8I3PYA9_CANLF Neutral amino acid transporter 9 (Solute carrier family 38 member 9) SLC38A9 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid stimulus [GO:0071230]; positive regulation of TORC1 signaling [GO:1904263] FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; Ragulator complex [GO:0071986] cholesterol binding [GO:0015485]; guanyl-nucleotide exchange factor activity [GO:0005085]; L-arginine transmembrane transporter activity [GO:0061459]; L-asparagine transmembrane transporter activity [GO:0015182]; L-glutamine transmembrane transporter activity [GO:0015186]; L-leucine transmembrane transporter activity [GO:0015190]; metal ion binding [GO:0046872]; sterol sensor activity [GO:0032935] LEFHWFMQTEYFVPEIRFQFPQL;VICPSAGSGGSP;VICPSAGSGGSPE 3 6.5 1.0029 -0.84036 0 11.4921 0 0 0 0 0 0 0 0 0 0 11.1064 0 8.56727 A0A8I3PYE1 A0A8I3PYE1_CANLF Sp5 transcription factor SP5 Canis lupus familiaris (Dog) (Canis familiaris) bone morphogenesis [GO:0060349]; cellular response to organic cyclic compound [GO:0071407]; post-anal tail morphogenesis [GO:0036342] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" PLAATARR;QYQSQIAALLQTKAPL 2 5.5 0.9905 -0.21351 13.5427 0 0 0 0 11.8701 0 0 0 13.1972 0 0 0 0 13.4629 A0A8I3PYE9 A0A8I3PYE9_CANLF Endoribonuclease LACTB2 (Beta-lactamase-like protein 2) LACTB2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] ILGEGTTIFEDL;QEIIVTHW;TQQYVYLQ 3 9.7 1.0029 -1.9038 0 0 8.73799 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PYG7 A0A8I3PYG7_CANLF DNA-binding protein SATB (Special AT-rich sequence-binding protein) SATB2 Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; chromatin remodeling [GO:0006338]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; roof of mouth development [GO:0060021] histone deacetylase complex [GO:0000118]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HHSERMQHVVQ;KAVGGLMIPVFCVVEQLDGS;KCQEFGRWYKKYKKIKVERV;QEFGRWYKKYKKIKV;RVERENLSDYCVLGQ 5 8.7 0.99389 -0.05759 0 0 0 0 0 8.35711 0 10.6556 0 0 0 0 7.51901 0 8.80455 A0A8I3PYG8 A0A8I3PYG8_CANLF Mitochondrial nucleoid factor 1 (Mitochondrial protein M19) UQCC2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial nucleoid [GO:0042645] YLRQRVAQAFR 1 9.9 0.9814 0.035491 0 0 0 0 0 0 0 0 0 9.431 0 0 0 0 0 A0A8I3PYH1 A0A8I3PYH1_CANLF Acrosin (EC 3.4.21.10) ACR Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; penetration of zona pellucida [GO:0007341]; proteolysis [GO:0006508] acrosomal vesicle [GO:0001669]; protein-containing complex [GO:0032991] D-mannose binding [GO:0005537]; serine-type endopeptidase activity [GO:0004252] IIIHESYVPSLEYNDIALM;SGGPLMCRDN 2 7 0.9905 -0.26719 0 0 8.57244 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PYH2 A0A8I3PYH2_CANLF Protein sprouty homolog 2 SPRY2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to vascular endothelial growth factor stimulus [GO:0035924]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] actin cytoskeleton [GO:0015629]; microtubule end [GO:1990752]; ruffle membrane [GO:0032587] protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539] CSNDDEDNCADNPCS;DEDNCADNPC;NDDEDNCADNPCSC;RVPLSRSISTVS;SNDDEDNCADNPCSCS;SNDDEDNCADNPCSCSQSHC;VGRQRGEPDPRDAL 7 14.9 1.0004 -0.61807 4.18118 0 5.25746 6.72219 6.95396 0 0 11.3083 0 0 0 10.9765 0 0 6.28581 A0A8I3PYI1 A0A8I3PYI1_CANLF ferroxidase (EC 1.16.3.1) HEPH Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322] EAFQESNRMHAI;IDMLASVLISMSAILLL;LKNFATRPYTIHP;QPLWPQWTDGATRVYYL;SFLKSDKNRIGS;SLYPDGSSGQLKAD 6 8.8 0.99677 -0.59014 0 0 11.0895 8.62968 0 0 10.1016 8.14741 0 6.58903 0 0 0 0 0 A0A8I3PYI5 A0A8I3PYI5_CANLF ATPase H+ transporting V1 subunit E2 ATP6V1E2 Canis lupus familiaris (Dog) (Canis familiaris) "acrosomal vesicle [GO:0001669]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DLLLVEAAVL;VSNTLESRLDLL 2 9.7 1.0009 -0.92432 0 0 0 0 0 0 10.9182 0 0 0 0 0 0 0 0 A0A8I3PYK6 A0A8I3PYK6_CANLF N-terminal E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) (EC 2.3.2.25) UBE2W Canis lupus familiaris (Dog) (Canis familiaris) GVTRARRLRPLRLWPR;LWPRRPWGDGSIM 2 13.9 0.91889 0.11924 0 7.30122 0 0 0 0 0 0 0 0 9.49456 0 0 0 0 A0A8I3PYN1 A0A8I3PYN1_CANLF Gametogenetin-binding protein 2 (Protein ZNF403) GGNBP2 Canis lupus familiaris (Dog) (Canis familiaris) DDTLTMVMEFP;HCEDKEDDGDSCVECWANSEE;KNKKKKKKAKML;LVAVCRDGEEEFPFERRQIPLYID;SCVHHCEDKEDDGDSCVECWA;SPHCNGSDCGYSSSMEGS 6 12.8 0.69032 0.26988 2.90506 0 7.31832 0 7.89348 7.40684 0 0 0 5.79901 10.1762 0 4.43536 7.42164 0 A0A8I3PYN9 A0A8I3PYN9_CANLF Selectin P ligand SELPLG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPSTAPASTGHLTTV 1 3.4 0.93484 0.065857 0 8.82308 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PYP3 A0A8I3PYP3_CANLF Zinc finger BED-type containing 2 ZBED2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of keratinocyte differentiation [GO:0045618] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" HGQVGQRK 1 3.7 1.0047 -1.1044 0 15.9243 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PYQ3 A0A8I3PYQ3_CANLF Spalt like transcription factor 4 SALL4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AAGEPGRSSLPSTF 1 5.1 0.99048 -0.1963 0 0 0 0 0 0 0 10.7328 0 0 0 0 0 0 0 A0A8I3PYS0 A0A8I3PYS0_CANLF Metal transporter CNNM2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular manganese ion homeostasis [GO:0030026]; magnesium ion homeostasis [GO:0010960] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] magnesium ion transmembrane transporter activity [GO:0015095] CCCGAGGCA;FNDTKLDAMLE;LEDVIEEIIKSEILDETDLYTDNR;LLSCCCGAGGCAAAGE;LRKMEKSKSYYL;MLRVTDPYNDLVKEELNIIQ;SCCCGAGGCA;VSKLLDCVLGQE 8 11.1 1.0026 -2.1796 6.77558 0 8.89839 0 8.83048 9.53294 8.18973 8.11837 11.258 0 7.89014 10.4935 8.95794 9.21172 7.94445 A0A8I3PYS3 A0A8I3PYS3_CANLF Telomere repeat binding bouquet formation protein 2 TERB2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair involved in meiotic recombination [GO:1990918]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] "chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]" DTLRIYQSLDYIEDNATVFH 1 9 0.9486 0.050192 0 0 0 0 0 0 0 0 0 0 0 0 8.45142 0 0 A0A8I3PYT9 A0A8I3PYT9_CANLF Zinc finger protein 76 ZNF76 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVQTEVGLE;SVIPLCLLPLLFTT 2 3.3 0.98924 -0.26547 0 0 0 0 0 0 0 0 13.1027 0 0 0 0 0 0 A0A8I3PYU2 A0A8I3PYU2_CANLF "Serine peptidase inhibitor, Kunitz type 1" SPINT1 Canis lupus familiaris (Dog) (Canis familiaris) serine-type endopeptidase inhibitor activity [GO:0004867] EELQNIHF;FINYLTREV;ILGYCFFKNQRKSFYRHRHSHH;LECDDTPDCPDASDEATCEKY;QNIHFPSDKGH;TEFRCRNGCCIDSFLECDDTPDCP 6 15.7 1.0014 -0.93908 0 0 7.27668 0 10.332 0 9.53984 13.2917 0 0 0 0 7.67694 0 0 A0A8I3PYW1 A0A8I3PYW1_CANLF "XPC complex subunit, DNA damage recognition and repair factor" XPC Canis lupus familiaris (Dog) (Canis familiaris) mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to UV-B [GO:0010224]; UV-damage excision repair [GO:0070914] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; site of DNA damage [GO:0090734]; XPC complex [GO:0071942] damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; protein-containing complex binding [GO:0044877]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; single-stranded DNA binding [GO:0003697]; transcription coactivator activity [GO:0003713] AAVDKGSCEEDDEEESED;CEEDDEEESEDEWEE;DGDGSVRD;DKGSCEEDDEEES;DKGSCEEDDEEESEDEWE;GTYKNHPLYALKRHLLKYEA;IDGDGSVRDVTQRYDPA;NWKLLARGLLIRERL;NWKLLARGLLIRERLKLRYG 9 8.3 1.0031 -1.026 0 9.86669 7.4536 10.8545 0 0 0 0 11.361 3.04499 8.77985 0 5.25546 0 0 A0A8I3PYW4 A0A8I3PYW4_CANLF Uncharacterized protein CFAP97D2 Canis lupus familiaris (Dog) (Canis familiaris) LSLSHLHLKFKKLKL;VIDRDNRLLLE 2 26.5 0.99514 -0.19043 0 0 0 0 0 0 0 0 0 11.6347 5.63697 0 0 0 0 A0A8I3PYW5 A0A8I3PYW5_CANLF Cilia and flagella associated protein 61 CFAP61 Canis lupus familiaris (Dog) (Canis familiaris) sperm flagellum assembly [GO:0120316] membrane [GO:0016020] AHSLTSAL;DLFSAVQSG;DTLLKETYGEY;EIPCTPLNTLFMHLFVAV;GSEIVTGNAKNG;HYTKFFLKEILRL;ISLKEKPRKYLKRVF;SLVEKSILDYLHYNHYHLPMYAWPG;VIRDEMDIEYIRSHYNIEDFIY 9 10.8 1.0028 -2.5407 0 9.28068 0 0 0 10.0573 4.61912 11.3716 7.19417 0 0 0 0 9.57654 9.24926 A0A8I3PYX2 A0A8I3PYX2_CANLF Keratin 80 KRT80 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] ERAACAAGFGSSL;ETRWRFLQGQDSGTF;IVEEVKVQYD;LTMWADNT;LVPLDLKVDPA;QEELRKVSQERGQ;SVVQSRSRP 7 15.6 1.0037 -1.6508 8.54094 0 0 8.86545 5.63238 0 0 9.05317 0 0 0 9.14756 0 0 0 A0A8I3PYY4 A0A8I3PYY4_CANLF Potassium voltage-gated channel subfamily B member 2 KCNB2 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] dendrite [GO:0030425]; perikaryon [GO:0043204]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] QIFRIMRILRILKL;SPQDTSHN;STKDSADD;VIDLLAILPY;VLVIALPIPIIVN 5 5.8 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.43463 A0A8I3PYZ9 A0A8I3PYZ9_CANLF Microtubule associated protein 1S MAP1S Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule [GO:0005874] microtubule binding [GO:0008017] ATPSQESSLEL;GGLGDAAF;PEPLKFPPPLP;RSWDIDPSICS;VISGQDQRKEEGMRAI;VTTPSLPAEVGSPHSTE 6 7.3 0.997 -0.59738 0 11.1846 15.3586 0 0 0 9.75579 0 0 0 0 6.72451 0 5.98108 6.16651 A0A8I3PZ01 A0A8I3PZ01_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HIPLSEDEHGRWYLELM;STLKCFVKEEDKP 2 16 0.91913 0.11707 0 0 0 0 0 0 7.31985 0 0 0 0 0 0 8.2213 0 A0A8I3PZ21 A0A8I3PZ21_CANLF Growth hormone regulated TBC protein 1 GRTP1 Canis lupus familiaris (Dog) (Canis familiaris) ETVFRIWDCLF;LPAVAALMDGHGVLW 2 7.7 0.99258 -0.55385 0 0 0 0 0 9.34645 0 0 0 0 0 0 0 0 0 A0A8I3PZ22 A0A8I3PZ22_CANLF Tropomodulin 3 TMOD3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] striated muscle thin filament [GO:0005865] tropomyosin binding [GO:0005523] LSYLEKEALEHKDREDYVPYT;VLDDLDPENAL 2 11.4 0.98961 -0.52624 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7333 0 A0A8I3PZ34 A0A8I3PZ34_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2C1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] AVDLSIDESSLTGETTPCSK;LYSKTSQSVSG;NLILKILVSSIIIVCG;QEYRSEKSL;VIWDCVLSNEEYLSA 5 7.2 0.95185 0.053904 0 0 0 0 0 9.38774 0 0 0 0 0 0 0 0 0 A0A8I3PZ45 A0A8I3PZ45_CANLF Syntrophin gamma 1 SNTG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] structural molecule activity [GO:0005198] DILMIQEQDVICV 1 3.5 0.9942 -0.12376 0 0 0 0 0 11.2279 0 0 0 0 0 0 0 0 0 A0A8I3PZ48 A0A8I3PZ48_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CYDDDDSGNEDNNAIIDG;DDEDEEEDADCYDDDDSGNE;DEEEDADCYDDDD;DEEEDADCYDDDDSGNE;DEEEDADCYDDDDSGNEDNNA;DGVAKCLALCLVCRSH;EDADCYDDDDSGN;EEDADCYDDDDSGNE;EEDADCYDDDDSGNEDN;EEEDADCYDDDDSGNE;ELKSLQEEPV;IDDEDEEEDADC;LVDESYLYNWEVAIFRPPNTLYE;YEGDIDDEDEEEDADCYDDD;YLYNWEVAIFRPP 15 32.8 0.40136 0.55955 8.84251 0 8.32733 0 0 4.99684 10.2603 0 0 0 6.31575 8.73961 5.06178 7.181 0 A0A8I3PZ49 A0A8I3PZ49_CANLF Tubulin delta 1 TUBD1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200] EENGGINWQVRP;QCGNQIGFEVFDALYSDSHCPQGLC 2 18.6 0.94549 0.05044 6.63134 0 0 0 0 0 7.0237 0 6.65935 0 0 0 0 0 0 A0A8I3PZ51 A0A8I3PZ51_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) DZIP3 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630] DDDDDEEE;IKDLQEVKSKPKKKKK;IQEDSATEDKFYSLDELHILD;LDDDDDEEEPC;NMEPSSSDLSKS;QRIELEELQNEEEELSPPL;VTHMAASNLESL 7 8.2 0.99212 -0.034349 0 0 0 8.48868 0 0 0 0 7.65828 0 0 7.08651 0 6.61633 11.7383 A0A8I3PZ60 A0A8I3PZ60_CANLF Mesenchyme homeobox 2 MEOX2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; limb development [GO:0060173]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; roof of mouth development [GO:0060021]; skeletal muscle tissue development [GO:0007519]; somite specification [GO:0001757] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDSHDSDHSSE;GAACAPGD 2 6.3 0.98153 0.035491 6.40725 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PZ67 A0A8I3PZ67_CANLF "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)" PLCB1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] ADTESDDDDDDDDC;ADTESDDDDDDDDCKKS;AGEADTESDDDDDDDDC;DKQQQQLLNLRQEQYYSE;DTESDDDDDDDD;DTESDDDDDDDDC;DTESDDDDDDDDCKKSSMDE;EADTESDDDDD;FVKWDDDSTIVT;GAGEADTESDDDDDDDDC;GEADTESDDDDDDDD;GEADTESDDDDDDDDCKKSSMD;LAQNMSRDAF;SDDDDDDD;SDDDDDDDD;SDDDDDDDDC;SDDDDDDDDCKKSSMDE;SDDDDDDDDCKKSSMDEGTAGS;SEAPSEAGTNPAENGVNHTTS;TESDDDDDDDDC;VDGFMRYLSGEENGV 21 9 1.0017 -0.96309 5.29682 0 5.35861 0 0 10.2215 9.46677 0 6.72506 0 0 4.83274 9.98114 7.29398 10.4273 A0A8I3PZ87 A0A8I3PZ87_CANLF Schwannomin interacting protein 1 C-terminal domain-containing protein LOC478678 Canis lupus familiaris (Dog) (Canis familiaris) EARCLLRIWMRFRQKQDYREDGMDL;GGGGGGGG;GGGGGGGGK;VIDEWAPEE;VIDEWAPEED 5 9.2 0.97912 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 9.91824 0 A0A8I3PZA8 A0A8I3PZA8_CANLF Olfactory receptor family 6 subfamily C member 87 OR6C87 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FCDSNMID;ISLGDKSITYHACVSQL;VFSTCSSH;WLKEQMVIVC 4 14.2 1.0033 -1.5802 0 0 11.2236 0 9.12758 0 0 0 0 7.59984 0 0 0 0 0 A0A8I3PZB3 A0A8I3PZB3_CANLF Uncharacterized protein RANBP6 Canis lupus familiaris (Dog) (Canis familiaris) AAAVSAGGPATVSG 1 20.6 0.90183 0.12112 0 0 12.4305 0 11.4932 0 0 0 0 0 12.7201 0 0 8.37478 0 A0A8I3PZC7 A0A8I3PZC7_CANLF IQ motif and Sec7 domain ArfGEF 2 IQSEC2 Canis lupus familiaris (Dog) (Canis familiaris) ESREEEEEEETEEEEEEDA;ESREEEEEEETEEEEEEDAHQFC 2 30.7 0.92782 0.095663 0 0 5.58087 0 0 0 0 0 0 0 0 0 0 6.33287 7.79993 A0A8I3PZD2 A0A8I3PZD2_CANLF AP-2 complex subunit mu AP2M1 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] AP-2 adaptor complex [GO:0030122] clathrin adaptor activity [GO:0035615]; lipid binding [GO:0008289] AEIELLPTNDKK;PFRVIPLVREVGRTKLEVKV;QCVRLSKFDSERSISFIPP;RSISFIPPD;VGRTKLEVKVVIK 5 12.7 0.98816 -0.31967 0 0 0 6.29135 0 0 4.28177 0 0 0 0 0 0 7.83592 0 A0A8I3PZD7 A0A8I3PZD7_CANLF PNKD metallo-beta-lactamase domain containing PNKD Canis lupus familiaris (Dog) (Canis familiaris) "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]" membrane [GO:0016020]; mitochondrion [GO:0005739]; presynaptic cytosol [GO:0099523] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] GNRDLSRRHQDC;GVLLASPRSRRARRTLRGL;LDTVLGLE;RQRMERKSTCPSTLGEERSYNPFL 4 12.5 1.0017 -0.69552 0 0 0 0 0 5.36356 0 10.1697 0 0 0 0 0 0 0 A0A8I3PZF2 A0A8I3PZF2_CANLF N-acylglucosamine 2-epimerase (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) RENBP Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] isomerase activity [GO:0016853] LEWAMKLWWPHSEAMIAFL 1 4.4 0.95012 0.049713 0 0 0 0 0 0 0 0 0 0 0 0 0 8.63681 0 A0A8I3PZF9 A0A8I3PZF9_CANLF C-type lectin domain family 4 member G CLEC4G Canis lupus familiaris (Dog) (Canis familiaris) alpha-beta T cell proliferation [GO:0046633]; immature T cell proliferation in thymus [GO:0033080]; negative regulation of alpha-beta T cell proliferation [GO:0046642]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; negative regulation of T cell mediated immunity [GO:0002710]; positive regulation of viral life cycle [GO:1903902]; T cell mediated immunity [GO:0002456] plasma membrane [GO:0005886] carbohydrate derivative binding [GO:0097367]; D-mannose binding [GO:0005537]; fructose binding [GO:0070061]; polysaccharide binding [GO:0030247]; virus coreceptor activity [GO:0120274]; virus receptor activity [GO:0001618] VGDLEEQGFLSRNT 1 4.6 0.93392 0.10501 0 0 0 8.44186 0 0 0 0 0 0 6.92434 0 0 0 0 A0A8I3PZH4 A0A8I3PZH4_CANLF TELO2 interacting protein 1 TTI1 Canis lupus familiaris (Dog) (Canis familiaris) ATSAMMDICHTCGYY;DLNKVADACLIYLSAKQP;HTLAFKLQ;ILEEYTSQENWY;LDELEQKQLGDLFA;LNELVAGAAGLEVEN;RLIQSVVECL;TMGQGNPY 8 9.8 1.0033 -2.2826 0 0 0 0 0 0 0 8.39348 9.54009 0 0 0 12.0671 0 11.0916 A0A8I3PZH7 A0A8I3PZH7_CANLF Testis expressed 36 TEX36 Canis lupus familiaris (Dog) (Canis familiaris) EKRQHVSRN;ISYVYQEVV;QRGYTEFLKKKPKVRFAI 3 19.4 1.0031 -0.87264 0 7.12278 0 0 0 0 0 0 0 0 0 0 0 12.3768 0 A0A8I3PZI3 A0A8I3PZI3_CANLF MCF.2 cell line derived transforming sequence like MCF2L Canis lupus familiaris (Dog) (Canis familiaris) DTLPRQEPG;EEEGRVGPRKLVPGKY 2 6.2 0.98497 -0.24135 0 0 0 0 0 0 0 0 11.9605 0 0 0 0 0 0 A0A8I3PZI6 A0A8I3PZI6_CANLF Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLKRSPNDCHQPRTIP;ENCGGGSFGS;SPNDCHQPR 3 3.6 0.98793 -0.37674 0 0 0 10.5832 0 0 0 0 0 0 0 0 0 0 0 A0A8I3PZI8 A0A8I3PZI8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] AEDEADCHCATDH 1 10.4 0.95209 0.059561 0 0 0 0 0 3.8265 0 0 0 0 0 0 0 0 0 A0A8I3PZK6 A0A8I3PZK6_CANLF Oligophrenin-1 OPHN1 Canis lupus familiaris (Dog) (Canis familiaris) "actin cytoskeleton organization [GO:0030036]; cell junction assembly [GO:0034329]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cerebellar granule cell differentiation [GO:0021707]; cerebral cortex neuron differentiation [GO:0021895]; establishment of epithelial cell apical/basal polarity [GO:0045198]; negative regulation of proteasomal protein catabolic process [GO:1901799]; neuron projection development [GO:0031175]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488]" actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; terminal bouton [GO:0043195] actin binding [GO:0003779]; GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543] DSFSKARP 1 1 0.99464 -0.17368 0 0 0 0 0 0 0 11.1496 0 0 0 0 0 0 0 A0A8I3PZL7 A0A8I3PZL7_CANLF IF rod domain-containing protein KRT127 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] QGLGGSGGFPLSI;TASSDQRACIKY;VLEAKWCLLQEQSATS 3 7.1 0.98329 -0.2539 9.05183 0 0 0 0 7.61846 0 0 0 0 0 0 0 0 0 A0A8I3PZM9 A0A8I3PZM9_CANLF "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.57) (3'-phosphoadenosine 5'-phosphate phosphatase) (Bisphosphate 3'-nucleotidase 1) (Inositol-polyphosphate 1-phosphatase)" BPNT1 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] "3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; metal ion binding [GO:0046872]" DPLDGTKEYTEGLLDNVTVLI;GVLATLRNYDYYASRV 2 13.6 0.99289 -0.19138 0 0 0 7.64472 0 0 0 0 0 0 0 8.98362 10.8947 0 9.2076 A0A8I3PZP2 A0A8I3PZP2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] CTGSWAQSVLTQPASVSGS;DYYCSTYDSSLSGGTVLQAC;LQAEDEADYYCSTYDS;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 35.8 0.97346 0.048206 0 0 8.46062 0 0 0 0 0 0 0 0 0 0 0 7.92671 A0A8I3PZP3 A0A8I3PZP3_CANLF PNKD metallo-beta-lactamase domain containing PNKD Canis lupus familiaris (Dog) (Canis familiaris) QNMRASNTGEYES;VGLAWAIGFPCGIL 2 19 0.984 -0.25452 0 0 0 0 0 0 0 0 0 0 0 7.79539 0 0 0 A0A8I3PZQ2 A0A8I3PZQ2_CANLF Solute carrier family 16 member 6 SLC16A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ELTTSPKNVPSQANVELEP;FLPTVTILSQYFD 2 6.1 0.99391 -0.17449 0 0 0 0 0 0 10.7772 0 9.57682 0 0 0 0 0 0 A0A8I3PZQ5 A0A8I3PZQ5_CANLF Phosphatidylinositol-glycan biosynthesis class W protein (EC 2.3.-.-) PIGW Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506]; protein localization to plasma membrane [GO:0072659] endoplasmic reticulum membrane [GO:0005789] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]" GGFIFGTAMVCPEVRRK;NLAFCIWIVASSL 2 6 0.9843 -0.24385 0 0 0 0 0 0 0 0 6.56159 0 0 0 0 0 0 A0A8I3PZQ8 A0A8I3PZQ8_CANLF Nuclear factor of activated T cells 2 NFATC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ELIDTHLSWIQ;GHPVVQLHGYMENKPLGLQ;LGSQPYYPQHPMVAESP 3 5.3 0.98638 -0.4256 0 10.1458 0 0 0 0 9.76553 0 0 0 0 0 8.3447 0 0 A0A8I3PZR9 A0A8I3PZR9_CANLF SplA/ryanodine receptor domain and SOCS box containing 1 SPSB1 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] SCF ubiquitin ligase complex [GO:0019005] DLLLDMPPVS;IVPDSFLVALDMDDGTL 2 9.9 0.99455 -0.15492 0 0 0 0 0 0 8.51361 0 0 0 0 8.91871 0 0 0 A0A8I3PZS8 A0A8I3PZS8_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) PPM1B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine/threonine phosphatase activity [GO:0004722] EQLVSPEPEVYEIL;LNPHRENDGASEEAEE;LPPGGGLAGK 3 8.4 1.003 -0.85273 0 0 0 0 3.77252 0 0 0 0 0 0 0 0 0 6.80374 A0A8I3PZT3 A0A8I3PZT3_CANLF palmitoyl-protein hydrolase (EC 3.1.2.22) LYPLAL1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cGAS/STING signaling pathway [GO:0160049] cytosol [GO:0005829] palmitoyl-(protein) hydrolase activity [GO:0008474] CQVLTDLIDD;GVLPELFQCH;VLPELFQCHGT 3 9.3 1.0026 -0.8983 0 0 0 0 0 0 0 5.47538 0 0 0 0 0 5.84977 0 A0A8I3PZT6 A0A8I3PZT6_CANLF Mitogen-activated protein kinase (EC 2.7.11.24) MAPK1 Canis lupus familiaris (Dog) (Canis familiaris) caveolin-mediated endocytosis [GO:0072584]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] caveola [GO:0005901]; centrosome [GO:0005813]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; nucleus [GO:0005634]; spindle [GO:0005819] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EQALAHPYLE 1 3.2 0.99899 -0.61146 0 0 0 0 0 9.2848 0 0 0 0 0 0 0 0 0 A0A8I3PZT9 A0A8I3PZT9_CANLF Zinc finger protein 408 ZNF408 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DGSMDEEDPAQT;HCPHCADA;SYSSEESFK 3 3.9 1.0024 -1.8582 0 0 0 0 0 0 0 7.60043 0 7.55536 0 4.58352 0 0 0 A0A8I3PZU5 A0A8I3PZU5_CANLF RNA polymerase-associated protein LEO1 LEO1 Canis lupus familiaris (Dog) (Canis familiaris) endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368] Cdc73/Paf1 complex [GO:0016593]; centrosome [GO:0005813]; fibrillar center [GO:0001650] RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269] DEKQNSDDEERPQ;KEEERLRASIRRESQQRRMR;KKLTSDEEGEPSGKRK 3 7.4 0.99436 -0.12289 0 0 0 0 0 0 0 4.50329 6.68692 0 0 0 0 0 0 A0A8I3PZV4 A0A8I3PZV4_CANLF Protein Wnt WNT5A Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] ARPKDLPRDWLWG;VQTERCHCKFHWCCY 2 7.7 0.9192 0.1136 0 0 0 0 6.66135 0 8.18105 0 0 0 0 0 0 0 0 A0A8I3PZV6 A0A8I3PZV6_CANLF Peroxisomal membrane protein PEX16 PEX16 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome organization [GO:0007031] peroxisomal membrane [GO:0005778] ILRKELRKKLPVPLSQ;LSDRKGLTRRERLELRRRTILLLY;LYYLLRSPFYDR 3 14.9 0.98869 -0.22388 5.78824 0 0 0 0 0 0 0 0 4.2163 0 0 0 6.81186 0 A0A8I3PZW8 A0A8I3PZW8_CANLF Internexin neuronal intermediate filament protein alpha INA Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; neurofilament cytoskeleton organization [GO:0060052]; postsynaptic modulation of chemical synaptic transmission [GO:0099170] cytoplasmic ribonucleoprotein granule [GO:0036464]; neurofilament [GO:0005883]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685] structural constituent of postsynaptic intermediate filament cytoskeleton [GO:0099184] ACSSAASLGLGLAYRRTPASDGLDL;WYKSKFANLNEQAA 2 7.8 0.98735 -0.23061 7.37756 0 0 0 0 0 0 11.0825 0 0 0 0 0 0 0 A0A8I3PZX1 A0A8I3PZX1_CANLF Protein FAM72A FAM72A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] QIKLTFSG;TFSGIFLVE 2 8.2 1.0013 -1.3158 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.3706 A0A8I3PZY6 A0A8I3PZY6_CANLF Huntingtin interacting protein K HYPK Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821] cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] protein folding chaperone [GO:0044183] DLELIVSSNAKISIWAEF 1 14.8 0.95087 0.04967 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 A0A8I3PZY7 A0A8I3PZY7_CANLF Toll like receptor 8 TLR8 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165] membrane [GO:0016020] APFPCTPCEGGASIQIHPLA;IVSLELTTCISDTL;NHNANPQHLSENP;SLEELVFSGNRLDILWNAEG;TDVICSSPGDQRGK;VLCIFTSFITVTVM;YVFQELRAGDF 7 10.2 0.997 -0.59364 0 6.4956 0 0 8.4271 11.7426 0 0 0 0 0 0 0 0 5.64815 A0A8I3PZZ5 A0A8I3PZZ5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) gamete generation [GO:0007276]; regulation of DNA-templated transcription [GO:0006355] cytosol [GO:0005829]; nucleoplasm [GO:0005654] methylated histone binding [GO:0035064] LDQLRLLESVMHT;VGCRIQPG 2 22.6 1.0018 -1.2607 0 0 0 0 0 6.83895 0 0 0 0 10.5373 0 0 0 0 A0A8I3PZZ6 A0A8I3PZZ6_CANLF Transforming growth factor beta TGFB2 Canis lupus familiaris (Dog) (Canis familiaris) cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cardioblast differentiation [GO:0010002]; cell morphogenesis [GO:0000902]; cell-cell junction organization [GO:0045216]; collagen fibril organization [GO:0030199]; embryonic digestive tract development [GO:0048566]; epithelial cell differentiation [GO:0030855]; extrinsic apoptotic signaling pathway [GO:0097191]; eye development [GO:0001654]; glial cell migration [GO:0008347]; hair follicle development [GO:0001942]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of macrophage cytokine production [GO:0010936]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell division [GO:0051781]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of heart contraction [GO:0045823]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of timing of catagen [GO:0051795]; regulation of transforming growth factor beta2 production [GO:0032909]; response to hypoxia [GO:0001666]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] amyloid-beta binding [GO:0001540]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein homodimerization activity [GO:0042803]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] VLCGYLDAIP 1 2.3 0.99928 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.51207 A0A8I3Q019 A0A8I3Q019_CANLF Armadillo repeat-containing protein 8 ARMC8 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] cytoplasm [GO:0005737]; GID complex [GO:0034657] FCISNLIWNEE;GAIRTDDN;SPVTPEELLY 3 4.8 1.0036 -1.0682 0 0 0 0 0 0 9.38094 0 0 0 0 0 0 0 9.15684 A0A8I3Q020 A0A8I3Q020_CANLF "Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (Fatty acid-binding protein, epidermal)" Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] lipid binding [GO:0008289] LVQHQEWDEKESTITRKLEDGK 1 20.8 0.97669 0.047387 0 0 0 0 0 0 0 8.74325 0 0 0 0 0 0 0 A0A8I3Q026 A0A8I3Q026_CANLF Collagen type VI alpha 3 chain COL6A3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; neuron apoptotic process [GO:0051402]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; response to UV [GO:0009411] collagen trimer [GO:0005581]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; sarcolemma [GO:0042383] serine-type endopeptidase inhibitor activity [GO:0004867] AAKPEATKTATVKPAVAVKPAAA;AVAQYADTVRPEFYFN;DEISQPAQELKRNSIM;DSKKKSVLLDKIKNLQVAL;DVFFKLLDKPTELNEEPLM;EHFQLVREFLYDVIK;FLKDFSTKQQIID;GGPPGPKG;GVSGSPGDP;GVTPAPPGV;LFTSSAGY;LTTYVSGGVEEVPLA;LVDSSWSIGKE;TVPEFRSFGDLQEQLLPY;VLETLHDAMHET;VPQLLIVL 16 6.9 0.99899 -3.1388 9.4508 9.95239 8.64627 0 10.1579 3.65844 9.10845 8.35874 13.5119 7.49993 0 0 5.4633 11.5357 8.97622 A0A8I3Q029 A0A8I3Q029_CANLF Lysine rich nucleolar protein 1 Canis lupus familiaris (Dog) (Canis familiaris) KKKKKKKV;KKKKKKKVVK;KKKKKRKSL;LLSMDILAVSIFCCWKQ 4 8.7 1.0028 -0.87842 0 3.53941 0 0 0 0 0 0 0 5.60309 0 0 0 2.57306 0 A0A8I3Q037 A0A8I3Q037_CANLF Delta-like protein JAG1 Canis lupus familiaris (Dog) (Canis familiaris) aorta morphogenesis [GO:0035909]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; inhibition of neuroepithelial cell differentiation [GO:0002085]; inner ear auditory receptor cell differentiation [GO:0042491]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; neuroendocrine cell differentiation [GO:0061101]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation [GO:0050678]; regulation of reproductive process [GO:2000241]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] adherens junction [GO:0005912]; apical plasma membrane [GO:0016324] calcium ion binding [GO:0005509]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543] DDCSPNNCSHGGTCQDLV;DGAKWDDDCNTCQC;EGYSGPNCEIAEHAC;TNDCSPHPCYNSGTCVDGD;VGECRSSSLQPVKTKCT;YYCDCLPGWTGQNCDI 6 8.1 0.97957 0.048313 0 0 0 5.84273 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q062 A0A8I3Q062_CANLF Sodium/hydrogen exchanger SLC9A7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] ALPPRLLLLPLLPLLLGR;HVFSPVFIIGAF;LLLLPLLPLLLGRGLRAA;LLLPLLPLLL;PRLLLLPLLPLLLGRGLRAAA;RALPPRLLLLPLLPLLLGR;RALPPRLLLLPLLPLLLGRGLRA 7 5.2 0.98917 -0.22629 0 0 0 4.95592 0 3.52155 0 0 0 5.26397 6.04302 0 5.32218 3.84599 0 A0A8I3Q068 A0A8I3Q068_CANLF Pleckstrin homology like domain family B member 2 PHLDB2 Canis lupus familiaris (Dog) (Canis familiaris) APPLGACA;GAPPLSPP;HQKASLHDADLPVFGSIGQSSASL;NNLIMMLQREKENLCNLEKKYS;RGYNHQQMSEGQRQK;SIPASPRVARK;SLDSSDSMETS;TLSIPASPRVARKMLL 8 8.8 0.98819 -0.47671 0 0 0 10.7544 0 0 0 10.4767 0 0 0 10.2283 0 0 0 A0A8I3Q071 A0A8I3Q071_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FCWTRSCF 1 5.4 1.0047 -1.1044 0 5.70744 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q075 A0A8I3Q075_CANLF 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) PSMD13 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] "cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome regulatory particle, lid subcomplex [GO:0008541]" structural molecule activity [GO:0005198] VERFQTLKTA;VFNFGELLMHPVLE 2 6.9 1.003 -0.8778 0 7.7185 0 9.18297 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q081 A0A8I3Q081_CANLF Pro-thyrotropin-releasing hormone TRH Canis lupus familiaris (Dog) (Canis familiaris) hormone-mediated signaling pathway [GO:0009755] extracellular region [GO:0005576] thyrotropin-releasing hormone activity [GO:0008437] AQMSWEAEEEEGEEGEL 1 7.1 0.98307 0.046227 0 0 9.605 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q093 A0A8I3Q093_CANLF RIB43A-like with coiled-coils protein 1 RIBC1 Canis lupus familiaris (Dog) (Canis familiaris) LDVKWENQAL 1 4.2 0.97509 0.043828 0 0 12.759 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q097 A0A8I3Q097_CANLF Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DUSP5 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] RPAYDQGGPVEILPFLYLGSAYH 1 6 0.97663 0.046444 0 0 3.61377 0 0 0 0 0 8.54144 0 0 0 0 0 0 A0A8I3Q0A5 A0A8I3Q0A5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RLFLAPSPLLLTTVIKSL 1 4.6 0.97706 0.048313 0 0 0 0 0 0 0 0 0 6.10047 0 0 0 0 0 A0A8I3Q0A9 A0A8I3Q0A9_CANLF P2X purinoceptor P2RX4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic signaling pathway [GO:0097190]; cellular response to ATP [GO:0071318]; membrane depolarization [GO:0051899]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of endothelial cell chemotaxis [GO:2001028]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; relaxation of cardiac muscle [GO:0055119]; response to fluid shear stress [GO:0034405] lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; cadherin binding [GO:0045296]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; identical protein binding [GO:0042802]; ligand-gated calcium channel activity [GO:0099604]; purinergic nucleotide receptor activity [GO:0001614] CEVAAWCPVEDDTHVPEPA 1 4.9 0.98737 -0.23109 0 0 0 0 0 0 12.5077 0 0 0 0 0 0 0 0 A0A8I3Q0B9 A0A8I3Q0B9_CANLF Chloride channel protein 2 CLCN2 Canis lupus familiaris (Dog) (Canis familiaris) acinar cell differentiation [GO:0090425]; cell differentiation involved in salivary gland development [GO:0060689]; regulation of aldosterone biosynthetic process [GO:0032347]; retina development in camera-type eye [GO:0060041] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] voltage-gated chloride channel activity [GO:0005247] EPRALQYEQ;VGEDWIFLVL;WGPRSHHGLPREGSPS 3 3.9 0.98946 -0.52664 0 0 0 0 0 9.58716 0 0 0 0 0 0 0 0 12.8593 A0A8I3Q0C0 A0A8I3Q0C0_CANLF "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2)" DECR2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid catabolic process [GO:0009062] peroxisome [GO:0005777] "2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]" DIPLQRLGNKTEVAH;SEDECLPEYRH 2 8.9 0.98983 -0.19762 0 0 0 0 0 0 0 9.39157 0 7.45311 0 0 0 0 0 A0A8I3Q0C2 A0A8I3Q0C2_CANLF Ubiquitin-like modifier-activating enzyme 5 (UFM1-activating enzyme) UBA5 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; localization [GO:0051179]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709] cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270] GGGDGGGG;LSCVDNFEARMTINTAC;VGGGDGGG;VGRRRRRRRL 4 8.4 0.99319 -0.27882 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.90869 A0A8I3Q0C4 A0A8I3Q0C4_CANLF Cilia- and flagella-associated protein 43 CFAP43 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; mucociliary clearance [GO:0120197]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288] 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; extracellular region [GO:0005576] DGQNILVNGKDDGTLVHLRWRRFGG;ELENFQLL;ETGRSRLDIFTLPKIL;FMAKADTLWSE;HEMEQQLL;LHELTVLQEEKVRFQ;PSAVTVWTI;QEAIKNEVKLFSKK;RRTKLKGNVLLDYTLL;TDEELKELKRVLWQKKI 10 8.3 1.0031 -1.5554 5.25995 0 0 12.3951 0 0 0 9.93678 8.2374 9.2971 3.41143 0 0 3.42116 0 A0A8I3Q0C5 A0A8I3Q0C5_CANLF Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10) OPALIN Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CGPSLGLAAGIPSL 1 11.9 0.99401 -0.12105 0 0 0 0 0 0 0 0 0 9.26489 0 0 0 0 0 A0A8I3Q0C6 A0A8I3Q0C6_CANLF Chromosome 2 open reading frame 50 C2orf50 Canis lupus familiaris (Dog) (Canis familiaris) PLFSDTVPSSTNQVVGS 1 7.1 0.98314 0.046227 0 0 0 0 0 0 0 0 10.8077 0 0 0 0 0 0 A0A8I3Q0C9 A0A8I3Q0C9_CANLF 5-azacytidine-induced protein 2 AZI2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] KDNSESLKVLNEQLQSKE;VLSEKAVLQSWTDN;YEDIKKRLK 3 11.7 1.0015 -0.69442 0 13.0302 0 0 9.72212 0 0 0 0 0 0 0 0 0 0 A0A8I3Q0D2 A0A8I3Q0D2_CANLF Proteasome assembly chaperone 1 PSMG1 Canis lupus familiaris (Dog) (Canis familiaris) proteasome core complex assembly [GO:0080129] endoplasmic reticulum [GO:0005783] proteasome binding [GO:0070628] EDREVRRQLARKREVRLFRRQTKT 1 9 0.97416 0.041303 0 0 6.73742 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q0D8 A0A8I3Q0D8_CANLF Protein Wnt WNT5B Canis lupus familiaris (Dog) (Canis familiaris) chondrocyte differentiation [GO:0002062]; positive regulation of cell migration [GO:0030335]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] EDLVYVDSSPD;GVVHAVSRACREGE;VGAPLQKP;WGGCGDNVEYGYRF 4 9.1 1.0022 -1.2701 0 0 0 0 0 8.91552 7.43463 0 7.88234 9.41722 8.82899 0 10.2729 8.24184 8.13525 A0A8I3Q0F8 A0A8I3Q0F8_CANLF "Mucin 4, cell surface associated" MUC4 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] AWMFGDPHITTLDG;DMLYREHNLLVQQVESWINK;LFHYGMTW;LPAEYRGRTEGLL;RCLVAGNPFTPAAPA 5 6.2 1.0019 -1.7985 4.06402 0 0 0 0 6.24662 0 0 8.5901 0 8.83042 0 0 0 0 A0A8I3Q0I7 A0A8I3Q0I7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] chromatin binding [GO:0003682] HAYSETHQECDNTI 1 5.1 0.93907 0.060769 9.22533 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q0L4 A0A8I3Q0L4_CANLF Progestin and adipoQ receptor family member 9 PAQR9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] HQLFHIFTFLSIYD;LEAPPAAPTFSG;LEAPPAAPTFSGTV;WCSYPFALRTFVFV 4 11.1 0.98692 -0.23492 0 0 8.89084 0 0 11.4888 0 0 0 0 0 0 8.70839 0 0 A0A8I3Q0L6 A0A8I3Q0L6_CANLF "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase)" ALG3 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] "alpha-1,3-mannosyltransferase activity [GO:0000033]" EALFLHRAFHVALLAAH;FSRSLHYQFYVWYFHTLPYLLWA 2 9.1 0.99349 -0.28615 0 0 0 0 0 0 0 0 0 0 0 0 9.17498 0 0 A0A8I3Q0M1 A0A8I3Q0M1_CANLF FAM20A golgi associated secretory pathway pseudokinase FAM20A Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activator activity [GO:0043539] IIDMAIFDFL;SPLSQCCR;YRRKVARWNRRHKMYK 3 6.3 1.0034 -1.6859 7.83567 7.08502 0 0 0 0 9.38262 0 6.90147 0 0 0 6.44571 6.89978 0 A0A8I3Q0N1 A0A8I3Q0N1_CANLF Spermatosis and oosis specific basic helix-loop-helix 2 SOHLH2 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" KTYFSNTVKNEYSMKPEEPGLP;PSYDAAAITNQNI;TASILEAT 3 10.1 0.98209 -0.25061 11.4509 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q0P4 A0A8I3Q0P4_CANLF Dickkopf WNT signaling pathway inhibitor 1 DKK1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of mesodermal cell fate specification [GO:0042662]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly [GO:1904723]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of endodermal cell fate specification [GO:0042663]; regulation of receptor internalization [GO:0002090] extracellular space [GO:0005615]; plasma membrane [GO:0005886] co-receptor binding [GO:0039706]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] AEDEECSPEEYC;EETILESG;GGARSPGRSRAGAASSGHPRP;MCCPGNYCKNGICMPSD;PYPCAEDEECSPEEYC 5 16.8 1.0023 -1.2273 7.17562 8.88338 0 0 0 0 6.01801 0 0 0 0 7.94093 0 0 9.90536 A0A8I3Q0Q2 A0A8I3Q0Q2_CANLF Calcium/calmodulin dependent protein kinase kinase 2 CAMKK2 Canis lupus familiaris (Dog) (Canis familiaris) CAMKK-AMPK signaling cascade [GO:0061762] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LIKGIEYLHYQKI;PGPRARMHPLRP;VGTPAFMAPESL 3 6.9 1.0034 -0.83592 0 0 0 0 0 0 12.9576 0 0 0 0 0 0 9.56238 0 A0A8I3Q0Q3 A0A8I3Q0Q3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ALILINHPKKIKKLKTRN;FVALILINHPKKIKKLK;PRVGSGSPSVTRPR;PSVTRPRVGSGSPSVTRPRA 4 20.7 0.82529 0.20351 0 6.24717 0 0 0 3.40966 0 5.41193 11.0858 0 0 0 0 0 0 A0A8I3Q0Q6 A0A8I3Q0Q6_CANLF Voltage-dependent L-type calcium channel subunit beta-3 (Calcium channel voltage-dependent subunit beta 3) CACNB3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] DACEHLAEY;SLEHVPPYDV;VLNNPGKRTIIE 3 6.5 0.99639 -0.58237 0 0 0 0 0 0 0 13.9393 0 0 0 0 0 0 0 A0A8I3Q0R2 A0A8I3Q0R2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEDEADCYCST;EDEADCYCSTYDK;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 8 22.7 0.9235 0.095052 0 0 9.16211 0 0 0 6.71397 0 0 0 0 8.67941 6.76075 0 0 A0A8I3Q0S2 A0A8I3Q0S2_CANLF "Mago homolog B, exon junction complex subunit" Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] exon-exon junction complex [GO:0035145]; spliceosomal complex [GO:0005681] HDYVGHKGKFGHE 1 8.8 0.98643 -0.25984 0 0 0 0 0 0 0 0 9.74512 0 0 0 0 0 0 A0A8I3Q0S5 A0A8I3Q0S5_CANLF B-cell receptor-associated protein (BCR-associated protein) BCAP31 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein targeting to mitochondrion [GO:0006626]; response to endoplasmic reticulum stress [GO:0034976]; spermatogenesis [GO:0007283]" endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886] MHC class I protein binding [GO:0042288]; protein-containing complex binding [GO:0044877] VVLIVILVLL 1 4.1 0.9995 -0.61146 0 8.3927 0 0 0 0 0 0 0 0 7.87418 7.53029 0 3.86344 0 A0A8I3Q0S6 A0A8I3Q0S6_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of opsin-mediated signaling pathway [GO:0022400]; signal transduction [GO:0007165]; visual perception [GO:0007601] ATP binding [GO:0005524]; rhodopsin kinase activity [GO:0050254] ASPLFKDINWRQL;CKKLNKKRLKKRK;LNKKRLKKRK;LSKCEGLRESL;VGAFSTVK;VLSEAIKYPD;VSLAYAFETKTDLCLVM 7 12.8 1.0035 -2.3875 0 0 0 4.59586 9.92883 0 0 0 6.89057 8.1818 0 0 4.58171 0 10.7278 A0A8I3Q0T4 A0A8I3Q0T4_CANLF Metallophosphoesterase domain containing 2 MPPED2 Canis lupus familiaris (Dog) (Canis familiaris) LGLPSEVKKFNDWLDLVSH;PYGDILLHTGDFTELGLPSEVK 2 28.2 0.99134 -0.20628 0 0 0 0 0 0 10.343 0 0 0 0 0 0 0 10.5571 A0A8I3Q0T8 A0A8I3Q0T8_CANLF Sortilin related VPS10 domain containing receptor 1 SORCS1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APGACGGA;ASRDTAPSIIVASGNIGSELSDSDI;EPCVCTEADFDCDYGYERH;GAPRDGARPEPGTP;GVYFTLALENVQ;LAVFVIYKFKRRSSPPR;LGEPGEETLIM;NAILQDTKTIA;RCPEPPSGPAPRWAPA;VIYKFKRRSSPPRLGLIGKP;YSSAEFGRRWQLIQEG 11 13.6 0.98615 -0.4108 0 6.62172 9.72652 0 9.34418 0 9.63608 0 10.8858 0 2.47964 0 0 0 5.66104 A0A8I3Q0U4 A0A8I3Q0U4_CANLF Uncharacterized protein LOC607038 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] CQYSTVQFPSALQ;LPEQINYQLHDTDFQESPYCQY;RLSETVVLHLQGLIDFTKELPGF;YHYNALTCEGCKGFF 4 14.3 0.98675 -0.23369 0 10.6353 7.83099 0 0 8.46246 0 12.2628 0 5.76919 0 11.8568 12.0065 0 0 A0A8I3Q0U5 A0A8I3Q0U5_CANLF mRNA m(6)A methyltransferase (EC 2.1.1.348) METTL3 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of cap-independent translational initiation [GO:1903679]; primary miRNA processing [GO:0031053]; RNA methylation [GO:0001510]" cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; S-adenosyl-L-methionine binding [GO:1904047] IDACMDSEAP 1 1.7 0.99833 -0.61146 0 0 0 0 0 0 0 8.17218 0 0 0 0 0 0 0 A0A8I3Q0U9 A0A8I3Q0U9_CANLF Bombesin receptor subtype-3 BRS3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] bombesin receptor activity [GO:0004946] VGVSVFTLTI 1 2.5 0.98267 -0.24826 0 0 0 0 0 0 0 0 9.53064 0 0 0 0 0 0 A0A8I3Q0V4 A0A8I3Q0V4_CANLF BRCA2 and CDKN1A-interacting protein LOC100688306 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634]; spindle pole [GO:0000922] AEEEEEDGVEDED;DEDEDEEDSDEDEDEDDES;DEDEDEEDSDEDEDEDDESVDE;DEDEEDSDEDEDEDDESV;DGVEDEDEDEED;EDGVEDEDEDEEDSDEDEDEDDESV;EDSDEDEDEDDE;EEDSDEDEDEDDE;EEEDGVEDEDEDEEDSDEDED;EEEEEDGV;GVEDEDEDEE;GVEDEDEDEEDSD;GVEDEDEDEEDSDED;GVEDEDEDEEDSDEDE;GVEDEDEDEEDSDEDEDE;GVEDEDEDEEDSDEDEDED;VEDEDEDEEDSDED;VEDEDEDEEDSDEDEDEDDESV 18 10.2 0.98613 -0.41576 7.12578 6.35996 0 4.07279 0 6.89433 9.97885 9.13835 0 7.2212 7.89664 0 6.71136 0 0 A0A8I3Q0V7 A0A8I3Q0V7_CANLF MSL complex subunit 3 MSL3 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] MSL complex [GO:0072487]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634] NAAFSANER;NSCDNQNC;NTNSCDNQNCLQ 3 13.3 1.0041 -1.0539 0 0 5.7487 0 0 0 0 7.80652 0 0 0 0 0 0 0 A0A8I3Q0W3 A0A8I3Q0W3_CANLF Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) YJU2B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; response to virus [GO:0009615]" CHLCVNYIEMQTDP 1 3.5 0.984 -0.24769 0 0 12.0177 0 0 0 0 9.01589 9.37528 0 0 0 0 0 0 A0A8I3Q0W5 A0A8I3Q0W5_CANLF Intraflagellar transport 81 IFT81 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316] centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; intraciliary transport particle B [GO:0030992]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228] tubulin binding [GO:0015631] DSCAAGLESNRSKL;YKPPGNAT 2 3.3 0.99505 -0.15802 0 0 10.7006 0 9.63098 0 0 0 0 0 0 0 0 0 0 A0A8I3Q0X3 A0A8I3Q0X3_CANLF Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GAATLENC;RHQGRTAELSPA 2 5.3 1.0028 -1.3474 0 0 0 0 0 0 9.38498 0 9.67096 0 0 0 0 0 0 A0A8I3Q0Y8 A0A8I3Q0Y8_CANLF Divergent protein kinase domain 2B DIPK2B Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] TPDLVQGLPSPFLRCPSQ;VQDEIDAALAQCGDDA 2 7.9 0.99153 0.00027987 0 0 0 0 6.42742 0 0 0 11.4271 0 0 0 0 0 0 A0A8I3Q0Z9 A0A8I3Q0Z9_CANLF L antigen family member 3 Canis lupus familiaris (Dog) (Canis familiaris) GVSGGGGH;RWTAEDPVFFRISVNAFLDQ 2 20.1 0.98961 -0.21723 0 0 0 5.67268 0 0 0 0 0 0 0 6.19012 0 0 0 A0A8I3Q106 A0A8I3Q106_CANLF RAD51 recombinase RAD51 Canis lupus familiaris (Dog) (Canis familiaris) chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA recombinase assembly [GO:0000730]; DNA strand invasion [GO:0042148]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131] condensed nuclear chromosome [GO:0000794] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697] AKLVPMGFTTATEFHQR;LVPMGFTTATEFHQR;QITTGSKELDKLLQ 3 11.1 0.98503 -0.43981 13.9676 0 0 0 0 0 0 11.7316 0 0 0 0 13.874 13.9597 0 A0A8I3Q110 A0A8I3Q110_CANLF glutamate--tRNA ligase (EC 6.1.1.17) EPRS1 Canis lupus familiaris (Dog) (Canis familiaris) glutamyl-tRNA aminoacylation [GO:0006424]; prolyl-tRNA aminoacylation [GO:0006433] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; proline-tRNA ligase activity [GO:0004827] AEKASKDQVDVAVQE;EDVAMLHIKPDQFTYTSD;EYHDRDEQFY;FFFFFFYDSSFKYY 4 4 1.0039 -1.0434 9.79943 10.5607 0 0 0 0 0 9.24129 0 0 0 0 0 0 10.9571 A0A8I3Q112 A0A8I3Q112_CANLF Uncharacterized protein SET Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDEEE;DDEEGEGEEDDDDDEEEEGLE;DMDDEEGEGEEDDDDDEE;DMDDEEGEGEEDDDDDEEE;EDDDDDEEE;EDDDEGEEG;GDEDEGEEDEDDDEGEEGEED;IDEEGDEDEGEEDEDDDEGEEGE;IDEEGDEDEGEEDEDDDEGEEGEED;LEDIDEEGDEDE;MDDEEGEGEEDDDDDEEEEGL 11 18.4 0.93311 0.094332 0 0 0 0 0 0 0 6.60349 0 0 0 0 7.56697 0 0 A0A8I3Q117 A0A8I3Q117_CANLF Solute carrier family 6 member 9 SLC6A9 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] plasma membrane [GO:0005886] amino acid:sodium symporter activity [GO:0005283] AIVDEVGNEWIL;GGGAFMFPYFIM;RNGGGAFM 3 4.1 1.0033 -1.5819 0 0 10.5826 8.79064 8.68222 0 0 0 0 0 0 0 0 8.94495 9.86468 A0A8I3Q121 A0A8I3Q121_CANLF Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) NGLY1 Canis lupus familiaris (Dog) (Canis familiaris) glycoprotein catabolic process [GO:0006516] cytoplasm [GO:0005737] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] PSQAPPLPSQ;YVRVSNNNQTISGW 2 3.5 0.99064 -0.20965 0 0 0 0 0 0 9.3409 0 0 0 0 5.28474 0 0 0 A0A8I3Q127 A0A8I3Q127_CANLF Double-stranded RNA-binding protein Staufen homolog 2 STAU2 Canis lupus familiaris (Dog) (Canis familiaris) anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; protein localization to synapse [GO:0035418] cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; messenger ribonucleoprotein complex [GO:1990124]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729] KEPEESCPVCHFW;KKLPPLPVVEKPKLFF;LLMNGTSPTAE;RELLMNGTSPTAEAIGL;TVGNNEFFGEGKTRQAA;VEKPKLFFKK 6 10.6 0.94045 0.059849 0 0 0 0 0 0 0 0 0 0 0 9.92597 0 0 0 A0A8I3Q136 A0A8I3Q136_CANLF dual-specificity kinase (EC 2.7.12.1) CLK1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of RNA splicing [GO:0043484] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713] GLSTYDFI;TVFPTHDSKEH;YFSFLDEIVDTLGEGAF 3 10.5 0.99521 -0.15825 8.23228 0 0 0 0 0 0 9.44944 0 0 0 0 0 0 0 A0A8I3Q160 A0A8I3Q160_CANLF Zinc finger protein 76 ZNF76 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVQTEVGLE;ITQDGAQQVTIITSGAVVA 2 5.4 0.98263 -0.25396 0 0 8.44836 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q174 A0A8I3Q174_CANLF Solute carrier family 10 member 3 SLC10A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] GDGSVLEFEFPE 1 2.5 0.95542 0.05044 0 4.20711 0 0 0 0 0 0 4.81301 0 0 0 0 0 0 A0A8I3Q184 A0A8I3Q184_CANLF Uncharacterized protein LOC477391 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ENPYKCPLCG;LCGKAFIT;LVSVGCQFFQ;QKQEIISMEDIC 4 8.5 1.003 -1.918 0 0 0 7.93068 6.91133 0 12.2687 0 0 0 0 0 0 0 5.34905 A0A8I3Q187 A0A8I3Q187_CANLF protein kinase C (EC 2.7.11.13) PRKCD Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872] LFCTFQTKDHLFF 1 2 0.94028 0.05986 0 0 0 5.82873 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1A0 A0A8I3Q1A0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CTGSWAQSVLTQPASVSGS;LQAEDEADYYCSTYDS;RPLGVPDRFSGSRSGSTATLTI;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 34.5 0.97716 0.047387 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.56907 A0A8I3Q1A9 A0A8I3Q1A9_CANLF Docking protein 2 DOK2 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068] KNSAPPGP 1 2 0.98952 -0.26592 0 0 0 11.2487 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1B2 A0A8I3Q1B2_CANLF Histidine ammonia-lyase (EC 4.3.1.3) HAL Canis lupus familiaris (Dog) (Canis familiaris) L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557] cytoplasm [GO:0005737] histidine ammonia-lyase activity [GO:0004397] AAISERRIERLC;FLHKKSTKIPES;INVLAKGYSG;RCRMLLALRINVLAKG;YIEKYRMEHIP 5 8.2 0.98365 -0.2542 0 0 10.6474 0 0 0 0 5.76099 0 6.47662 0 10.1649 6.45124 0 10.5046 A0A8I3Q1B5 A0A8I3Q1B5_CANLF Septin-5 SEPTIN5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of exocytosis [GO:0017157] plasma membrane [GO:0005886]; septin complex [GO:0031105]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; identical protein binding [GO:0042802] EGLGLLIRPLLSRFSRHLPL;IHVYQFPECDSDEDED 2 8.6 0.9822 -0.2506 0 0 0 0 0 0 0 0 9.11814 0 0 0 0 0 0 A0A8I3Q1C1 A0A8I3Q1C1_CANLF Dynein axonemal assembly factor 4 DNAAF4 Canis lupus familiaris (Dog) (Canis familiaris) determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; heart development [GO:0007507]; inner dynein arm assembly [GO:0036159]; learning or memory [GO:0007611]; nervous system development [GO:0007399]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136] cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886] nuclear estrogen receptor binding [GO:0030331] DSIPAPRSIGSIKI;GTAFCQLELYIEG;SGVDKEMMQR 3 8.8 0.98617 -0.42046 0 0 9.76406 0 0 0 0 0 0 8.51167 0 0 0 0 0 A0A8I3Q1C2 A0A8I3Q1C2_CANLF BHLH domain-containing protein MXD1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] protein dimerization activity [GO:0046983] APGARGSPRLGFPRS;LSLLTKAKLHIKKL 2 6.5 0.99087 -0.2689 0 0 0 0 0 0 0 0 0 0 0 0 0 5.49336 0 A0A8I3Q1C4 A0A8I3Q1C4_CANLF H1.8 linker histone H1-8 Canis lupus familiaris (Dog) (Canis familiaris) chromosome condensation [GO:0030261]; negative regulation of DNA recombination [GO:0045910]; nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; nucleosomal DNA binding [GO:0031492] GPKAKAAA;GRQRAVLPSGA 2 5.5 1.0037 -1.0689 0 0 0 0 0 0 0 0 9.87623 12.139 12.025 12.0906 0 0 10.7454 A0A8I3Q1C6 A0A8I3Q1C6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MARCHF4 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] Golgi stack [GO:0005795]; membrane [GO:0016020]; trans-Golgi network [GO:0005802] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] CCCCCAWY;CCCCCCCAW;CCCCCCCAWYRC;CCCCCCCAWYRCG;DDWGGPATE;DLCYYKYHVIAI;HILSHLRPHEQRS;LWWWWWCCCCCCCAWYRCG;VGRETTPLPPAPPLPPSSVEDDWGG;WCCCCCCCA;WCCCCCCCAWY;WCCCCCCCAWYR;WWCCCCCCC;WWWCCCCCCC;WWWCCCCCCCA;WWWWWCCCCCCCAWYRCGLCAPAP 16 19 0.99663 -4.7535 3.84026 0 6.28838 4.26776 6.56479 0 8.02868 0 7.46344 0 4.99213 5.34437 6.31268 0 5.63802 A0A8I3Q1C8 A0A8I3Q1C8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WFQQTPGQAPRRIIYDTS 1 14.9 0.98617 -0.24591 0 3.90814 0 10.0311 0 0 0 0 0 0 0 0 5.12916 0 3.87303 A0A8I3Q1D2 A0A8I3Q1D2_CANLF Midkine (MK) LOC491316 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083]; heparin binding [GO:0008201] QLRGFLLLALPTLLALPAAVAK 1 15.4 0.97396 0.046699 0 6.8062 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1D6 A0A8I3Q1D6_CANLF GTP-binding nuclear protein Ran RAN Canis lupus familiaris (Dog) (Canis familiaris) nucleocytoplasmic transport [GO:0006913]; protein transport [GO:0015031] nuclear envelope [GO:0005635] GTP binding [GO:0005525]; GTPase activity [GO:0003924] PAPPGARRRRLRLRAFELRFRHL 1 4.9 0.9792 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 8.78647 0 0 A0A8I3Q1E6 A0A8I3Q1E6_CANLF Kelch like family member 34 KLHL34 Canis lupus familiaris (Dog) (Canis familiaris) ADGQALAS;EEEEEEEQVEEEEDWE;GSGEGGASSL;HRWRSLTRLPAPLL;QEEEEEEEEEEEQVEEEEDWELTQD 5 8.8 1.0034 -1.1107 0 0 0 7.88838 0 0 8.66633 0 0 13.2363 0 0 7.2521 0 0 A0A8I3Q1F6 A0A8I3Q1F6_CANLF Uncharacterized protein PPP1R2C Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] PDVVAKKLAASGTSRWS 1 8.2 0.97304 0.046736 0 0 0 0 9.52544 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1F8 A0A8I3Q1F8_CANLF Integrin subunit alpha 9 ITGA9 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EELVVMGAPGSFYWAGTVKV;EETCHHYVAHVKRRVQD;GILIFLLLAVLLWKH;GPAGSFFGYAVL;GSFSRPFTTDVVGGAPQDEG;VGQITEKLQLVYMEET 6 9.6 0.87646 0.14053 0 0 10.5582 0 0 0 9.28017 0 5.27943 0 0 0 8.72775 0 0 A0A8I3Q1G0 A0A8I3Q1G0_CANLF Caudal type homeobox 4 CDX4 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; labyrinthine layer development [GO:0060711]; negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IDAEAADASS 1 3.5 0.99985 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.75679 A0A8I3Q1G1 A0A8I3Q1G1_CANLF SAC3 domain containing 1 SAC3D1 Canis lupus familiaris (Dog) (Canis familiaris) AAVLEAALAV;FEVAPGCRSDPPRADPRRAVKEYQ;TCPDMCPAAE;TPKGQTLPLGFIV 4 15.9 1.0029 -1.1609 8.56029 6.40141 0 0 0 0 9.92307 0 0 0 0 0 0 0 0 A0A8I3Q1G4 A0A8I3Q1G4_CANLF Adipogenin ADIG Canis lupus familiaris (Dog) (Canis familiaris) brown fat cell differentiation [GO:0050873]; positive regulation of fat cell differentiation [GO:0045600]; spermatogenesis [GO:0007283]; white fat cell differentiation [GO:0050872] cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleus [GO:0005634] ENDSDLCFDWEPWS;VGLLLVLLIIWL;VGLLLVLLIIWLR;VGLLLVLLIIWLRF 4 35 0.78142 0.23154 0 0 7.55834 0 0 4.28924 4.4098 0 0 0 0 0 0 4.63401 4.621 A0A8I3Q1G7 A0A8I3Q1G7_CANLF G protein-coupled receptor 157 GPR157 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019] ciliary membrane [GO:0060170] G protein-coupled receptor activity [GO:0004930] ADKKLILIPLI;DLLSAASYFYGVL;LPVLYLLIRKHI;LSAASYFYGVL;PKPPSPTKWVHP;VTLPVLYLLIRK 6 14 0.99295 -0.049401 0 0 0 0 0 0 3.3835 4.81696 9.07898 0 3.40177 0 5.13278 0 0 A0A8I3Q1G8 A0A8I3Q1G8_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4B Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]" DHPGVSNQFL;LVLHATFPGHSQRRES;VFTDLEILATIFA;YMMTLEDHYHSD 4 7.1 0.68385 0.28418 0 0 0 0 7.57289 8.52038 12.3381 0 0 7.27798 0 0 0 0 0 A0A8I3Q1G9 A0A8I3Q1G9_CANLF Keratin 72 KRT72 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EFVVLKKD;ELLSTKLA;SFKPAAVDVK 3 5 0.99228 -0.5406 0 0 0 0 0 0 0 0 0 0 0 0 10.3964 0 0 A0A8I3Q1H1 A0A8I3Q1H1_CANLF "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (Complex I-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" NDUFS2 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; response to oxidative stress [GO:0006979]" mitochondrial respiratory chain complex I [GO:0005747]; nucleoplasm [GO:0005654] "4 iron, 4 sulfur cluster binding [GO:0051539]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; NADH dehydrogenase activity [GO:0003954]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]" PTKETAHW 1 1.7 0.98274 -0.25034 0 0 0 0 0 8.32233 0 0 0 0 0 0 0 0 0 A0A8I3Q1I2 A0A8I3Q1I2_CANLF IKBKB interacting protein IKBIP Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730] QSLNEKFQNVSDFWKRSLE 1 5.1 0.98687 -0.23366 0 0 0 0 0 0 0 0 0 0 0 0 13.3626 0 0 A0A8I3Q1J5 A0A8I3Q1J5_CANLF SET domain containing 9 SETD9 Canis lupus familiaris (Dog) (Canis familiaris) TLGFSVARATSSLISAGKGVF 1 7 0.9494 0.050014 0 9.3799 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1K8 A0A8I3Q1K8_CANLF "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)" COQ5 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial matrix [GO:0005759]; ubiquinone biosynthesis complex [GO:0110142] "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]" ALWSYCGRR;EVIAGDWKSY;LDVAGGTGDI;LSQEKPATE;LVESIRQFPSQEEFREMIEDAGFEK;VLGDAEELPFDDDKFD 6 24.2 1.0023 -0.7633 9.01153 0 9.51432 0 0 10.62 0 0 0 8.76736 0 8.50518 0 0 0 A0A8I3Q1L6 A0A8I3Q1L6_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G1B Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] CKFLLDNPYTKIYS;DYNDYGCYCGL;TPVDELDKCCQTHDHC;VDELDKCCQTHDHCY 4 30.4 0.77807 0.22971 0 6.07146 0 0 3.63796 0 8.44456 0 0 0 0 0 0 0 9.13525 A0A8I3Q1M3 A0A8I3Q1M3_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4A Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]" DHPGVSNQFL;DLLKKFRIP;DTCWHPPGRSVSFEA;LPALRTLPP;TDRIMAEFFQQGDRER 5 7.3 0.95257 0.053902 0 0 0 0 0 0 0 0 0 8.51527 0 0 0 0 0 A0A8I3Q1P3 A0A8I3Q1P3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESGGDLVKPG;ESGGDLVKPGG;ESVLGWVFLVAILQ;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VEGPGADADGGSGQVS;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG;VRQAPGKGLQ 27 29.9 0.98436 -0.23917 0 0 0 9.48613 0 0 0 0 0 12.3765 0 0 0 0 9.17911 A0A8I3Q1P9 A0A8I3Q1P9_CANLF PR/SET domain 11 PRDM11 Canis lupus familiaris (Dog) (Canis familiaris) CELKVVDQYMNEGDCQI;DFWFCESCQEYFVDECPN;DYYTKNGFKDL;ELRSTASTLCEETEFL;LDGQSDDLLAD;RFKQEWLKKFWF 6 7.2 1.0014 -0.70088 6.06234 0 0 0 9.39118 0 12.6078 0 0 0 8.18918 0 0 0 0 A0A8I3Q1Q2 A0A8I3Q1Q2_CANLF Bromodomain and WD repeat domain containing 1 PSMG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] CSSFSVGGMFLATGSTDHVIR;ELGASISVTSDE;IEAVRRNNIYEL;LSPPKRRRKRKKENKPK;LSVDDNDW;LSVDDNDWEDLDY;SESSSDSSSRYSDW;SFSVGGMFLAT;SIRNIKQKRLKSQTKVIP;TLEAGNYDSPLEFC;VLLSQSRQRSCRRKYPNYG;VTSDELEKLLYK;VTSDELEKLLYKP;YGLRRWNGRRLRTYGKA 14 7.2 1.0017 -2.6281 0 10.7783 0 0 8.73623 9.89729 11.359 0 0 8.75348 9.5796 14.1058 0 10.6654 0 A0A8I3Q1Q6 A0A8I3Q1Q6_CANLF Rho GDP dissociation inhibitor gamma ARHGDIG Canis lupus familiaris (Dog) (Canis familiaris) blastocyst hatching [GO:0001835]; regulation of protein localization [GO:0032880]; Rho protein signal transduction [GO:0007266] cytosol [GO:0005829]; plasma membrane [GO:0005886] Rho GDP-dissociation inhibitor activity [GO:0005094] AALQGQVFVLK 1 4.9 0.98963 -0.26608 12.2351 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1R3 A0A8I3Q1R3_CANLF Ubiquitin-related modifier 1 URM1 Canis lupus familiaris (Dog) (Canis familiaris) protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829]; nucleus [GO:0005634] protein tag activity [GO:0031386]; sulfur carrier activity [GO:0097163] DWELLVST 1 5.8 0.41333 0.55102 0 0 8.77929 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1T0 A0A8I3Q1T0_CANLF Uncharacterized protein LHFPL7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FAKGACGA 1 4 1.0042 -1.1044 0 0 0 0 8.61478 0 0 0 0 0 0 0 0 0 0 A0A8I3Q1T3 A0A8I3Q1T3_CANLF Tetratricopeptide repeat domain 7A TTC7A Canis lupus familiaris (Dog) (Canis familiaris) AGEITNNTTSRHL;HPVDYELTYFLEAALQ;PTSHSVLYMRGRLAE;PTVPLMAAKVCIG;VINMAITEYP;VRQISSAIEQLQEALK 6 10.2 0.98972 -0.21682 0 0 0 0 0 0 0 13.0472 0 0 0 0 0 0 0 A0A8I3Q1U3 A0A8I3Q1U3_CANLF Cytochrome P450 (EC 1.14.14.-) CYP2U1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" GGGGGGGG;LLYMSLNPDIQEK;PGAGHPPG;RTCKLCALH 4 5.4 1.0027 -1.0103 0 0 0 7.10591 9.34671 10.3393 0 0 0 0 0 0 0 0 0 A0A8I3Q1V0 A0A8I3Q1V0_CANLF Chromosome 1 open reading frame 141 C1orf141 Canis lupus familiaris (Dog) (Canis familiaris) DIVPSTSKKVPRITEDKSYSI;SSLTKKFV 2 6.5 0.99076 -0.21357 0 0 0 0 0 0 0 13.0859 0 5.84315 0 0 0 0 0 A0A8I3Q1V9 A0A8I3Q1V9_CANLF Dehydrogenase/reductase 11 DHRS11 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] 17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; 17-beta-ketosteroid reductase (NADPH) activity [GO:0072555]; 3-keto sterol reductase activity [GO:0000253]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303] VLSTPPHVQIGDIQMRPT 1 6.6 0.9459 0.061173 0 0 0 0 0 0 0 10.7535 11.0323 0 0 0 0 0 0 A0A8I3Q1W9 A0A8I3Q1W9_CANLF Thyrotropin releasing hormone degrading enzyme TRHDE Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] AWKFFRDKWKILNTR;GAEAGGSP;IVYCTGVSLLDEDVWEFI;KKKKRRKKEEEE;LISGVTEFLNTEGELKELKNFMKT;NWRLLIDQLIRN 6 8.7 1.0022 -0.66782 10.8991 0 0 0 9.6927 0 0 0 0 4.62375 0 0 7.77261 2.90275 0 A0A8I3Q1X4 A0A8I3Q1X4_CANLF Ribonuclease/angiogenin inhibitor 1 RNH1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LLCESLLE;LQLLCEGLLDPQCHLEKLQLE 2 6.8 1.0048 -1.0494 0 0 0 0 8.86031 0 0 0 7.2267 0 0 0 0 0 8.38797 A0A8I3Q1Z7 A0A8I3Q1Z7_CANLF Uncharacterized protein NPM2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; single fertilization [GO:0007338] nucleus [GO:0005634] EDDDDDDVDVSL;EEDPEEEEEEEEEDDDDDDVD;EEEEEDDDD;EEEEEDDDDDDVDVSLEETP;EEEEEEDDDDD;EEEEEEDDDDDDVDVSLEET;EVEEDPEEEEEEEEEDD;LKDQSPVKKAKPTLKPKKP 8 23 0.99177 -0.036771 0 0 4.46382 0 0 5.62831 0 8.70397 6.21859 6.87406 7.43829 7.79941 0 4.30932 0 A0A8I3Q1Z8 A0A8I3Q1Z8_CANLF Uncharacterized protein NUSAP1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of mitotic spindle localization [GO:0040001]; mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] PSLEELDSFKYSDLQNLAK 1 4.3 0.94853 0.050076 0 9.802 0 0 0 0 0 0 0 0 0 9.1631 0 0 0 A0A8I3Q200 A0A8I3Q200_CANLF "Boule homolog, RNA binding protein" BOLL Canis lupus familiaris (Dog) (Canis familiaris) 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; meiotic cell cycle [GO:0051321]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; translation activator activity [GO:0008494] KGYGFVTFETQEDAQKI;RSISSSPVMVAQPVYQQ 2 11.5 0.6375 0.33355 0 0 7.63923 0 0 0 0 0 0 0 0 0 0 0 11.5988 A0A8I3Q201 A0A8I3Q201_CANLF Centromere protein P CENPP Canis lupus familiaris (Dog) (Canis familiaris) CENP-A containing chromatin assembly [GO:0034080] inner kinetochore [GO:0000939]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ALESLITSLCPADNQFPANTQR;MGVRSACQPGFELVVVW 2 12.8 0.97632 0.047975 0 0 0 0 0 0 0 0 0 0 0 0 0 8.39172 0 A0A8I3Q202 A0A8I3Q202_CANLF Small ribosomal subunit protein eS6 (40S ribosomal protein S6) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KPRTKAPKIQRLVTPRVLQHKRWRI;RLVTPRVLQHKRWRIALKKQ;YRFLWGHKISFLWDKCP 3 23.7 0.87962 0.12997 0 0 0 6.83188 0 0 0 0 0 0 5.63613 0 6.82464 0 0 A0A8I3Q205 A0A8I3Q205_CANLF Rab GDP dissociation inhibitor GDI1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein targeting to membrane [GO:0090315]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; midbody [GO:0030496] GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093] GSESQVSRLSWPQL;NSCQIIIPQ;QNQVNRKSDIYVCMISY;YGGESSSI 4 10.2 1.003 -1.6644 0 0 0 5.39565 0 0 8.0077 0 0 0 0 0 0 0 0 A0A8I3Q216 A0A8I3Q216_CANLF DNA methyltransferase 1 associated protein 1 DMAP1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of cell cycle [GO:0051726] cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; replication fork [GO:0005657]; Swr1 complex [GO:0000812] RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714] KSSETLTFKRP;LVHMFNELRS;QEYQLYLHDD;SASSSSSVK 4 8.5 0.99206 -0.27195 0 0 0 0 0 0 9.43492 0 0 0 0 0 0 0 0 A0A8I3Q224 A0A8I3Q224_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD6A Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type deubiquitinase activity [GO:0004843] AETQHLASFRREEEEKL;PRLSRARRRRERR 2 10.5 0.93357 0.10579 0 0 7.61353 0 0 0 0 0 0 6.68902 0 0 0 8.70096 9.09574 A0A8I3Q225 A0A8I3Q225_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] LSSNSSQSN 1 11.5 0.99018 -0.26688 0 0 0 8.52258 0 0 0 6.24916 0 0 0 0 7.7057 5.46881 6.1429 A0A8I3Q237 A0A8I3Q237_CANLF Aspartate beta-hydroxylase ASPH Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101] AGAGTSGG;AKGGGGGS;SSSPGARRETKHGGHKN 3 15.9 1.0029 -2.1626 0 0 0 9.27247 0 0 0 9.36914 0 0 0 0 0 0 0 A0A8I3Q239 A0A8I3Q239_CANLF Ankyrin repeat domain 33 ANKRD33 Canis lupus familiaris (Dog) (Canis familiaris) skeletal muscle cell differentiation [GO:0035914] TVQRIRKLLRRPRI 1 3.6 0.98944 -0.26547 0 0 4.11203 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q240 A0A8I3Q240_CANLF Actin-related protein 8 ACTR8 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723] centrosome [GO:0005813]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654] ATP binding [GO:0005524] DIEVIWSHAIQKYLEIP;IDCCSSDD;RHKQQGQPLY 3 5.6 1.0019 -1.272 0 0 0 9.56327 0 0 0 5.89772 10.2501 0 0 0 0 0 0 A0A8I3Q249 A0A8I3Q249_CANLF "Carnitine O-palmitoyltransferase 1, muscle isoform (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (Carnitine palmitoyltransferase 1B)" CPT1B Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] mitochondrial outer membrane [GO:0005741] acyltransferase activity [GO:0016746] APRLQKYLVLKSWWATNYVSDWWEE;VGWGRALGCRD 2 4.5 0.99722 -0.59631 0 0 0 0 0 0 0 0 11.0631 0 0 0 0 0 0 A0A8I3Q252 A0A8I3Q252_CANLF Tetratricopeptide repeat domain 28 TTC28 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346] midbody [GO:0030496] kinase binding [GO:0019900] DLHDKLSQAKAYCNLGLA;EQLISRAVKNMVGMLHQV;HQLDLQIAEETNNPTCQG;IASSMSFVSKPEAGSEAGGA;LSVAQSLNRMQD;MRDSLEPTYQ;VGQELLTAGHHGASVVVL;VLTPSVDSN 8 5 1.0028 -0.7336 10.022 0 10.2859 0 0 0 11.1293 9.15886 6.86777 0 10.7347 0 0 0 7.57372 A0A8I3Q264 A0A8I3Q264_CANLF Mtr4 exosome RNA helicase MTREX Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460]; RNA catabolic process [GO:0006401] nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] KALFATETF;VGLMTGDVTI 3 3.2 1.0031 -1.9247 9.3912 0 4.2135 8.37803 2.92184 0 0 0 0 0 5.0041 0 0 0 8.94509 A0A8I3Q266 A0A8I3Q266_CANLF Phosphorylase b kinase regulatory subunit PHKA1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516] DRFQAALE;EVDASLLSVI;QVSILAETEE;TPQFIDQQQFYLALD;VLADEVQHCQSI;VPPDKVDEEYQNPHTVDRVPMGKLP 6 8.1 1.0036 -1.1044 0 0 0 0 0 9.15821 0 0 0 0 0 0 0 0 0 A0A8I3Q267 A0A8I3Q267_CANLF Methylcytosine dioxygenase TET (EC 1.14.11.80) TET2 Canis lupus familiaris (Dog) (Canis familiaris) 5-methylcytosine catabolic process [GO:0006211]; chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166] nucleus [GO:0005634] 5-methylcytosine dioxygenase activity [GO:0070579]; zinc ion binding [GO:0008270] ELFAGNKTQNLHH;LFDHKALTLKS;QQQKLQMKNKEQMPQTFSQSQ;RCFQEQEQKPQQ;SILVKKAKVLRDVLL 5 6.1 0.95257 0.053874 0 0 0 0 0 0 0 0 0 0 5.96726 1.71506 0 0 0 A0A8I3Q270 A0A8I3Q270_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) ACVR2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] FCCCEGNFCNERFTHL;PPRYARVGRPPA;QVYFCCCEGNFC;YFCCCEGNFCNE;YPTSGFPRWLG 5 4.8 0.98941 -0.31007 0 10.9582 0 0 0 0 0 9.7545 4.85494 4.53804 0 0 0 0 2.90633 A0A8I3Q277 A0A8I3Q277_CANLF N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB catalytic subunit) NAA20 Canis lupus familiaris (Dog) (Canis familiaris) NatB complex [GO:0031416] peptide alpha-N-acetyltransferase activity [GO:0004596] INLDPLTETYGIPFYL;KAEGSVAREEWHG 2 26.1 0.99234 -0.065186 0 0 0 9.20247 0 7.78038 11.2836 0 0 0 0 0 0 0 0 A0A8I3Q278 A0A8I3Q278_CANLF ORC ubiquitin ligase 1 OBI1 Canis lupus familiaris (Dog) (Canis familiaris) protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275] chromatin [GO:0000785] chromatin binding [GO:0003682]; ubiquitin-protein transferase activity [GO:0004842] ESQIAQLKNSSEEKEAMNSICQR;LNSIRSFE;LTLPITCHICLGK;TSYAQNLDFESSEGNTIANSV 4 9.1 1.0021 -1.2714 0 0 5.34017 0 0 5.78743 0 0 0 0 0 0 9.65916 0 9.2755 A0A8I3Q282 A0A8I3Q282_CANLF Dynein 2 intermediate chain 2 DYNC2I2 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; filopodium [GO:0030175] dynein light chain binding [GO:0045503] DDTHTDPVYQV;EDLEQLAAEV;EGGFPLKCSL;PSAVVEVPSAVMCL;VLSAATDGKVLLW 5 10.8 1.0031 -1.5224 11.4659 0 0 0 0 0 12.4816 9.02992 0 0 0 0 0 0 0 A0A8I3Q293 A0A8I3Q293_CANLF Musashi RNA binding protein 1 MSI1 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; regulation of translation [GO:0006417] cytoplasm [GO:0005737]; nucleus [GO:0005634] identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; poly(U) RNA binding [GO:0008266] PSRTGGFLGTTSPGP;RTGGFLGTTSPGPM;STPSRTGGFLGTTSP;VTFESEDIVEKVCEIHF 4 9.7 0.98592 -0.42862 0 0 0 0 6.60196 8.70449 9.886 0 0 0 0 0 0 0 0 A0A8I3Q294 A0A8I3Q294_CANLF Mitochondrial chaperone BCS1 (BCS1-like protein) BCS1L Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial cytochrome c oxidase assembly [GO:0033617]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551] mitochondrial inner membrane [GO:0005743] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] PLSDFILALKDNPYFGAGFGLVG;VAFRRHYMITLE 2 8.4 0.93197 0.096823 0 0 0 0 0 0 0 0 0 0 0 0 0 9.51895 9.48063 A0A8I3Q2A4 A0A8I3Q2A4_CANLF Transmembrane protein 117 TMEM117 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] FLIFAEDPVSHSQTE;MDGNMGAYI;VGWRILKVLLWLLAI;VGWRILKVLLWLLAILIGLI 4 16.4 1.0036 -0.80421 0 6.69139 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2B0 A0A8I3Q2B0_CANLF Sodium/glucose cotransporter 1 (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) SLC5A1 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324] transmembrane transporter activity [GO:0022857] DIEVPEEKKG;YTEKVACTVPS 2 3.3 0.99034 -0.20009 0 11.4438 0 0 0 0 0 0 0 0 0 10.742 0 0 0 A0A8I3Q2B4 A0A8I3Q2B4_CANLF Septin-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; regulation of exocytosis [GO:0017157] cell division site [GO:0032153]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940]; synaptic vesicle [GO:0008021] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090] EFTLMLVGEWG 1 10.8 0.98327 -0.25374 10.5284 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2B9 A0A8I3Q2B9_CANLF Armadillo repeat containing 7 ARMC7 Canis lupus familiaris (Dog) (Canis familiaris) KEHILQTGGIPLI 1 6.6 0.9375 0.059848 0 0 6.61243 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2C0 A0A8I3Q2C0_CANLF Doublecortin domain containing 1 DCDC1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] microtubule binding [GO:0008017] HQRWMHKEDSRTFHLVSNPDLVL;KTPEVCVPV;LSMTAKEYHKAQEEV;QEEIKLMELIRHTEA;SLDPNAVLLPGCDNW;TEAHLSAVQE;TKSIARRQSSLYK;VIKTMEDYL;VISDSLDGIDKSLLT;VSKGEGFSP 10 7 1.0037 -2.0335 0 11.4521 9.86217 0 0 11.3446 10.7062 10.6194 11.7872 8.10952 0 9.79941 12.0113 10.9537 10.7524 A0A8I3Q2C2 A0A8I3Q2C2_CANLF Cytosolic fatty-acid binding proteins domain-containing protein RBP1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908]; retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776] cytosol [GO:0005829]; nucleus [GO:0005634] all-trans-retinol binding [GO:1904768]; fatty acid binding [GO:0005504] PPPPPPPPLLLPPPLSLLLLLLPP 1 7.2 0.97376 0.041303 0 0 0 0 0 0 0 8.47338 0 0 0 0 0 0 0 A0A8I3Q2C5 A0A8I3Q2C5_CANLF STIM activating enhancer STIMATE Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of calcineurin-NFAT signaling cascade [GO:0070886] cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268] calcium channel regulator activity [GO:0005246] IFEKSVVFIVLLILQWKKVALL;VGVRAVSVLVEWQQWESLR 2 13.9 0.99147 -0.20624 0 0 0 0 0 0 0 6.95652 0 0 0 0 0 0 0 A0A8I3Q2D0 A0A8I3Q2D0_CANLF Condensin-2 complex subunit H2 (Non-SMC condensin II complex subunit H2) NCAPH2 Canis lupus familiaris (Dog) (Canis familiaris) female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; mitotic sister chromatid separation [GO:0051306]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; T cell differentiation in thymus [GO:0033077] cell junction [GO:0030054]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654] ARFAHLLQPI;DEVEKNVSPLYSCQGEVL;EILIIPLLP;MEVSACCPI;WYVAGPAGGRVSPP 5 9.9 1.003 -1.7101 0 0 0 0 0 0 0 0 0 0 5.33432 0 0 4.0221 7.59746 A0A8I3Q2D5 A0A8I3Q2D5_CANLF Calreticulin CALR3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788]; nuclear envelope [GO:0005635] calcium ion binding [GO:0005509]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] IGHFRLSSGKFYGHKEK 1 4.4 0.98094 0.046227 0 0 0 0 0 0 0 0 9.47484 0 0 0 0 0 0 A0A8I3Q2E3 A0A8I3Q2E3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAQPEDEADYYC 1 10.1 0.95293 0.05044 0 6.897 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2E7 A0A8I3Q2E7_CANLF Gastrulation brain homeobox 2 GBX2 Canis lupus familiaris (Dog) (Canis familiaris) autonomic nervous system development [GO:0048483]; axon guidance [GO:0007411]; branching involved in blood vessel morphogenesis [GO:0001569]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellum development [GO:0021549]; forebrain neuron development [GO:0021884]; inner ear morphogenesis [GO:0042472]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; neural crest cell migration [GO:0001755]; regulation of nervous system development [GO:0051960]; rhombomere 2 development [GO:0021568]; thalamus development [GO:0021794] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" IPSLPTGFCSSL;SGGAAGST 2 5.7 1.0017 -1.3189 14.6142 9.16458 3.72857 0 0 0 0 0 0 0 2.9961 0 3.38446 14.5296 4.07262 A0A8I3Q2F2 A0A8I3Q2F2_CANLF C3a anaphylatoxin chemotactic receptor C3AR1 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of vascular endothelial growth factor production [GO:0010575] membrane [GO:0016020] complement component C3a receptor activity [GO:0004876]; G protein-coupled receptor activity [GO:0004930] LDNSIVQLPG;MYRETFTENNHDRCGYNFYLYSSFD;TIDLLDNGSLDNSIVQ;YGWLLCKLIPSI 4 11.6 1.0019 -1.4345 8.64631 0 0 0 0 0 0 0 9.40861 12.5349 0 0 12.3297 0 0 A0A8I3Q2F6 A0A8I3Q2F6_CANLF Nitric oxide synthase 1 adaptor protein NOS1AP Canis lupus familiaris (Dog) (Canis familiaris) NGEVSLSVP;RNGLKLSLS;VLSHPSPFLGPCKGSPRPSV 3 10.6 0.94349 0.059931 0 0 0 0 0 0 0 0 10.5847 0 0 0 0 0 0 A0A8I3Q2G0 A0A8I3Q2G0_CANLF Ribonuclease P/MRP protein subunit POP5 POP5 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364]; tRNA 5'-leader removal [GO:0001682] nucleolus [GO:0005730]; ribonuclease P complex [GO:0030677] ribonuclease P RNA binding [GO:0033204] QKFLIRYNRRQLLILLQN 1 15 0.97416 0.048313 0 0 6.91433 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2H4 A0A8I3Q2H4_CANLF Centrosomal protein 72 CEP72 Canis lupus familiaris (Dog) (Canis familiaris) LVDRYWSGCKSLHGNEVFQAQARH;SLDLSRNSLVSLEG;WSYKELKKTLA 3 8 0.87913 0.1378 0 0 0 0 0 0 0 0 9.89709 0 9.71699 0 0 0 0 A0A8I3Q2H7 A0A8I3Q2H7_CANLF Phospholipase A2 group XIIA PLA2G12A Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] EQAQTTDWRATL;PYLDSQRAACR 2 12.1 0.9829 -0.25099 0 0 0 0 0 0 0 0 0 8.60755 0 0 0 0 0 A0A8I3Q2H8 A0A8I3Q2H8_CANLF LIM/homeobox protein Lhx1 (Homeobox protein Lim-1) LHX1 Canis lupus familiaris (Dog) (Canis familiaris) branching involved in ureteric bud morphogenesis [GO:0001658]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; cervix development [GO:0060067]; comma-shaped body morphogenesis [GO:0072049]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic viscerocranium morphogenesis [GO:0048703]; endoderm formation [GO:0001706]; forebrain regionalization [GO:0021871]; lateral motor column neuron migration [GO:0097477]; mesendoderm development [GO:0048382]; metanephric renal vesicle morphogenesis [GO:0072283]; metanephric S-shaped body morphogenesis [GO:0072284]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct elongation [GO:0035849]; paramesonephric duct development [GO:0061205]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; pronephros development [GO:0048793]; retina layer formation [GO:0010842]; somite rostral/caudal axis specification [GO:0032525]; spinal cord association neuron differentiation [GO:0021527]; telencephalon development [GO:0021537]; transcription by RNA polymerase II [GO:0006366]; ureter morphogenesis [GO:0072197]; urogenital system development [GO:0001655]; uterine epithelium development [GO:0035847]; vagina development [GO:0060068]; ventral spinal cord development [GO:0021517] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]" SPSDLVRR 1 2 1.0043 -1.1044 0 0 0 0 0 0 0 0 7.17173 0 0 0 0 0 0 A0A8I3Q2I0 A0A8I3Q2I0_CANLF Uncharacterized protein PCP4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516] IDMDAPETERAAV 1 21 0.94316 0.059683 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.84486 A0A8I3Q2J7 A0A8I3Q2J7_CANLF Cytoplasmic polyadenylation element binding protein 3 CPEB3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-UTR binding [GO:0003730]; translation regulator activity [GO:0045182] CGGKFAPFFCANVTCLQYYCEYCWA;DAFLDDSHGD;DQMCDECQ;IFVGGVPRPL;KFPRAAPL;VCYAGIDTDPELK;VGGVPRPLRAVELAMI 7 11.6 0.99169 -0.54397 0 0 0 5.42479 0 0 0 0 0 0 0 0 0 13.3132 0 A0A8I3Q2K4 A0A8I3Q2K4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815] chromatin [GO:0000785] DEPLLDPKVSCKA 1 10.2 0.98323 -0.25207 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14.9032 A0A8I3Q2K8 A0A8I3Q2K8_CANLF Leucine rich repeat containing 27 LRRC27 Canis lupus familiaris (Dog) (Canis familiaris) EEVRQATQDL;LDPLEEVRQATQDLE;TDSPEDWPSEEEI;VISPVPTMN 4 6.9 1.0029 -0.87784 0 0 0 0 0 10.1248 0 0 0 0 0 0 0 9.88493 0 A0A8I3Q2M2 A0A8I3Q2M2_CANLF Gap junction protein GJA9 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] CQLEQRKLNKAP 1 2.3 0.99048 -0.26683 0 0 0 0 0 12.6025 0 0 0 0 0 0 0 0 0 A0A8I3Q2M8 A0A8I3Q2M8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SWI/SNF complex [GO:0016514] ALGVPPSP;PAALCHLLDHQKG 2 17.5 1.0028 -1.3857 0 0 0 0 0 12.391 0 0 0 0 0 0 0 0 0 A0A8I3Q2P0 A0A8I3Q2P0_CANLF Calcium binding protein 1 CABP1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306] AFGQDRSLRPE;ARGRDGEERGLFPALGLRGSL 2 8.7 0.99168 -0.18127 0 0 0 0 0 0 11.4816 0 0 0 0 0 0 0 5.65655 A0A8I3Q2Q2 A0A8I3Q2Q2_CANLF Cleavage stimulation factor 50 kDa subunit CSTF1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] GVSNRCITTFEK 1 2.8 0.94597 0.05044 0 0 0 0 0 9.76603 0 0 0 0 0 0 0 0 0 A0A8I3Q2Q7 A0A8I3Q2Q7_CANLF Phospholipase C delta 4 PLCD4 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] AEVQELFENFSAD;EELRRKILVKGKKL;PEELRRKILVKGKKL;RRKILVKGKKLR 4 3.8 0.78297 0.23265 0 6.17289 0 0 0 0 0 0 4.67288 0 0 7.85593 0 3.99747 4.6557 A0A8I3Q2R0 A0A8I3Q2R0_CANLF Neurobeachin Canis lupus familiaris (Dog) (Canis familiaris) protein localization [GO:0008104] cytosol [GO:0005829]; membrane [GO:0016020] protein kinase binding [GO:0019901] LLVGGEFD;LVSYNCFCT;MLGVLASYSITVK;NDSYDKCFL;PGPSPFSSFPF;TDLLFALETDVHVW;VGGENGALVEVES;VINPADSSGITPKGLD;VPIRNIRMKFAVLIG 9 6.4 1.0035 -1.1058 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.6703 A0A8I3Q2R2 A0A8I3Q2R2_CANLF Mitogen-activated protein kinase binding protein 1 MAPKBP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of interleukin-8 production [GO:0032717]; positive regulation of JNK cascade [GO:0046330] cytoplasm [GO:0005737]; mitotic spindle pole [GO:0097431]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AEHSQVAELQ;DGQVRMISCGADKSI;EDSESTEPLSV;FTRTHHVVRKTTL;TLDTSEFQ;TTLYDMDV;VGYQHDMIVNV;YPDTIALTFDPTNQ 8 7.1 1.0032 -2.0899 0 0 0 0 0 0 8.9354 0 0 0 0 0 7.90135 8.88829 9.57331 A0A8I3Q2R6 A0A8I3Q2R6_CANLF Uncharacterized protein LOC100684432 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex II assembly [GO:0034553] mitochondrion [GO:0005739] PGAKARAQ 1 7.3 0.98949 -0.26592 0 0 8.22612 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2S9 A0A8I3Q2S9_CANLF Mitochondrial amidoxime reducing component 2 (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) MTARC1 Canis lupus familiaris (Dog) (Canis familiaris) nitrate metabolic process [GO:0042126] mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; peroxisome [GO:0005777] molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; pyridoxal phosphate binding [GO:0030170] SPIMILSEASLADLNT 1 6.2 0.67105 0.27888 0 0 0 0 0 0 0 10.2893 0 0 0 0 0 0 0 A0A8I3Q2T0 A0A8I3Q2T0_CANLF "Alpha-1,4 glucan phosphorylase (EC 2.4.1.1)" PYGM Canis lupus familiaris (Dog) (Canis familiaris) glycogen catabolic process [GO:0005980] glycogen phosphorylase activity [GO:0008184]; pyridoxal phosphate binding [GO:0030170] DTHPSLAIPELM;FSSDRTIAQYAREIWGI;GVENVTELKKNFNR;LFDIQVKRIH;TQQHYYEKDPKRIYYLSLEFYMGRT 5 9.3 1.0006 -0.92929 0 0 0 0 0 0 8.47261 0 0 0 11.2022 0 0 10.4251 10.1033 A0A8I3Q2T4 A0A8I3Q2T4_CANLF Period circadian regulator 1 PER1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] KYFGSIDSSEAEAGAAQ;LVEVTESS;SSSDSNGG 3 2.6 1.0029 -2.1626 9.34864 0 0 0 0 0 9.79602 0 0 0 10.3295 0 11.7202 0 0 A0A8I3Q2T6 A0A8I3Q2T6_CANLF Alpha-carbonic anhydrase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] APPGPWTLEN;DLHLVQQDP;IFQGYHSAP;SAGTWCYDSQDPK 4 12.5 1.0026 -1.1985 0 0 0 0 0 0 0 0 0 12.7239 0 0 0 0 0 A0A8I3Q2T9 A0A8I3Q2T9_CANLF Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) UBA1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974] cytosol [GO:0005829]; desmosome [GO:0030057]; endosome membrane [GO:0010008]; heterochromatin [GO:0000792]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; rough endoplasmic reticulum membrane [GO:0030867] ATP binding [GO:0005524]; ubiquitin activating enzyme activity [GO:0004839] FQVVVLTNTPLEDQLRVGE;GKNRAEVSQPRLAE;KMYPIDFEKDDD;PLTFDVNNVSL;VLGPYTFSIC;YVLGHEAMKRL 6 7.2 0.98949 -0.2146 0 0 0 10.5428 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q2U1 A0A8I3Q2U1_CANLF 5'-3' exoribonuclease (EC 3.1.13.-) XRN2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] 5'-3' RNA exonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] ATYQGNLY;DQIVCSPVPMLR;EPEPEDNVRL;QRYYKNKFD;VLKPSDWEKSSNGRQWK;YYPFHYAPFA 6 7.6 0.99898 -2.9694 0 0 9.26803 0 0 9.17729 9.31696 0 6.80387 0 0 0 0 0 0 A0A8I3Q2V9 A0A8I3Q2V9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLFVELENGFILVFFLMNYFRS 1 23.9 0.95432 0.052079 0 0 0 0 0 0 0 0 0 0 0 0 8.91528 0 0 A0A8I3Q2X3 A0A8I3Q2X3_CANLF Phosphatidate cytidylyltransferase (EC 2.7.7.41) CDS2 Canis lupus familiaris (Dog) (Canis familiaris) CDP-diacylglycerol biosynthetic process [GO:0016024]; lipid droplet formation [GO:0140042] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] phosphatidate cytidylyltransferase activity [GO:0004605] EPRWRRCACA;FRTLSWYFLLCVNY;HNLFEGMIWFIVPISC;PGSPSMTELRQR;VIHNLFEGMIWFIVPISCVICND 5 10.3 1.0032 -1.7161 0 0 0 10.619 0 0 9.9747 0 0 0 0 0 0 0 10.1097 A0A8I3Q2X7 A0A8I3Q2X7_CANLF Myocardial zonula adherens protein MYZAP Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; maintenance of ER location [GO:0051685] "I band [GO:0031674]; nuclear envelope [GO:0005635]; RNA polymerase II, holoenzyme [GO:0016591]" ESLKKKVQQKQLLILQLL;SLKKKVQQKQLLILQLLE;THPAPLAPPPLAPP 3 5.2 0.98956 -0.21614 0 0 0 4.8775 0 0 0 0 0 4.07596 0 0 0 0 0 A0A8I3Q2X8 A0A8I3Q2X8_CANLF Parathymosin PTMS Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] histone binding [GO:0042393] AEDGEEEDEGEEEDEEEEEDDD;DEGEEEDEEEEEDDDEGPAL;EDGEEEDEGEEEDEEEEEDDDEG;EEEDEGEEEDEEEEEDDDE;EGEEEDEEEEEDDDEGPA;ETAEDGEEEDEGEE 6 28.4 0.68539 0.29965 0 3.97416 0 7.22535 0 0 0 0 0 0 0 7.56087 0 5.67347 4.25225 A0A8I3Q2Z1 A0A8I3Q2Z1_CANLF Intercellular adhesion molecule 5 ICAM5 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] integrin binding [GO:0005178] CTLDELFPASEAGV;STESPPQMDESTCPS 2 3.4 0.98639 -0.38857 0 0 9.62282 0 0 0 0 0 0 0 0 0 0 0 12.0816 A0A8I3Q2Z2 A0A8I3Q2Z2_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCD1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] GVGRDMASRQTAVVTNNGFNP;LDGVTTSLPSPEEDK 2 4.5 0.99115 -0.22142 0 0 0 0 0 0 0 0 0 0 0 10.744 0 0 0 A0A8I3Q2Z3 A0A8I3Q2Z3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TQGKAPRMLIYNTN;TVVTQEPSL;TVVTQEPSLSVSPG 3 27.5 0.98517 -0.25912 0 10.6621 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q303 A0A8I3Q303_CANLF Clathrin heavy chain CLTCL1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439] clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198] AETGQFQKIVLY;IDMSEPMVPI;IVLYAKKVGYVP;LDRAYEFAER;LVDLAMPYFIQVMREYL;NPEWLISFFGSLS;TWKEVCFACVD;VGQPAAGN;WSMEGDSQPVKMFDRH 9 6.6 0.99865 -3.0168 11.675 8.65385 0 0 0 10.8424 0 9.69511 0 0 10.1989 0 11.0366 0 4.21808 A0A8I3Q307 A0A8I3Q307_CANLF Bet1 golgi vesicular membrane trafficking protein like BET1L Canis lupus familiaris (Dog) (Canis familiaris) LDRENKRMAD;VEEILDRENKRM 2 15.2 0.94866 0.081495 0 14.3455 0 0 8.19972 14.545 0 0 0 0 0 0 0 0 0 A0A8I3Q328 A0A8I3Q328_CANLF Claudin CLDN5 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; establishment of blood-retinal barrier [GO:1990963]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of gene expression [GO:0010629]; negative regulation of vascular permeability [GO:0043116]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of gene expression [GO:0010628]; transforming growth factor beta receptor signaling pathway [GO:0007179] apicolateral plasma membrane [GO:0016327]; bicellular tight junction [GO:0005923]; cortical actin cytoskeleton [GO:0030864] structural molecule activity [GO:0005198] STEVQAARAL 1 4.6 0.98384 -0.25261 0 0 0 0 0 0 0 0 10.1887 0 0 0 0 0 0 A0A8I3Q333 A0A8I3Q333_CANLF Uncharacterized protein LOC100687968 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] EDNTCSED;LWAMLGFPRKF 2 10.1 0.9908 -0.51391 10.0771 0 6.14853 0 0 0 0 0 0 0 0 10.858 10.5881 0 0 A0A8I3Q335 A0A8I3Q335_CANLF DALR anticodon binding domain containing 3 DALRD3 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] DLLWWKLDD;EWLLLFNGVLPFP;VGETLGAL 3 5.5 1.0029 -1.0068 10.9292 10.9629 0 7.88978 0 0 10.8488 0 10.8848 0 0 0 9.53128 0 0 A0A8I3Q336 A0A8I3Q336_CANLF Plakophilin 3 PKP3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] GPARGHYHTLQPGFSSRSQ;LDLGAGPG;LLYFDGLRKLVFIKKKR;LRKLVFIKK;RRLRELPLT;VNIIAVLNNLVVA 6 8.2 0.99884 -2.942 0 9.53202 0 0 6.73931 0 0 0 9.43402 0 0 4.84875 7.16702 0 0 A0A8I3Q337 A0A8I3Q337_CANLF Vang-like protein VANGL1 Canis lupus familiaris (Dog) (Canis familiaris) pigmentation [GO:0043473] lateral plasma membrane [GO:0016328] YLSAGPTLQY 1 1.9 0.99942 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5994 A0A8I3Q347 A0A8I3Q347_CANLF Kinase (EC 2.7.-.-) IP6K2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to flavonoid [GO:1905396]; inositol phosphate biosynthetic process [GO:0032958]; negative regulation of cell growth [GO:0030308]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821] cell junction [GO:0030054]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] flavonoid binding [GO:0097243]; inositol hexakisphosphate 5-kinase activity [GO:0000832] EKMKSHKLEEEFEWL;NETTLCKPLV 2 5.9 0.99126 -0.18169 8.83086 0 0 0 0 0 0 0 0 0 0 9.2979 0 0 0 A0A8I3Q356 A0A8I3Q356_CANLF SAP30 binding protein SAP30BP Canis lupus familiaris (Dog) (Canis familiaris) modulation by host of symbiont transcription [GO:0052472]; regulation of DNA-templated transcription [GO:0006355]; response to virus [GO:0009615] intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654] IDELGTNYPKD;QSEDDDSETEKP 2 7.5 0.9879 -0.47083 0 0 10.0147 0 0 0 0 0 0 9.47098 0 0 0 0 0 A0A8I3Q361 A0A8I3Q361_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] GEGIPHHPGL;LCHLVSTSSNSSCGSAE;STSSNSSCGSAEDPG 3 25.4 0.99469 -0.56052 0 10.0853 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q386 A0A8I3Q386_CANLF RAS p21 protein activator 3 RASA3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] LYIQANNCVE;TVYHPSAY;VVYTEDHVFSSDYY 3 4 1.0017 -1.41 0 0 0 0 0 0 0 0 8.64238 0 0 0 0 0 0 A0A8I3Q3A1 A0A8I3Q3A1_CANLF C-type lectin domain-containing protein CLEC2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] VLCVIFFILNILLIIV 1 8.6 0.9606 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.40088 A0A8I3Q3A5 A0A8I3Q3A5_CANLF Zinc fingers and homeoboxes 3 ZHX3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669] nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] AALPEGPPQ;CEPEEEGPG;EEGPGKPAE;GAVPVLPA;IVEQSVPESTCTPD;PGPGACEPEEEGPG;SQAFLDASIYKNKK 7 6.6 0.99889 -2.9704 0 0 0 0 0 8.82031 0 7.52152 0 0 4.00585 3.62246 7.30268 8.70373 10.6083 A0A8I3Q3B1 A0A8I3Q3B1_CANLF Single-pass membrane protein with coiled-coil domains 1 SMCO1 Canis lupus familiaris (Dog) (Canis familiaris) RALCTFFIAHGNKTEYYVAKV 1 9.8 0.94979 0.049792 0 0 0 0 0 0 7.83504 0 0 0 0 0 0 0 0 A0A8I3Q3B2 A0A8I3Q3B2_CANLF Histone PARylation factor 1 HPF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302] chromatin [GO:0000785]; nucleus [GO:0005634]; site of DNA damage [GO:0090734] chromatin binding [GO:0003682]; histone binding [GO:0042393]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] AAIKLFLMK;EDAEIMCECEKT;HYKLSLPEDFYHFWKFCEE 3 11.4 0.99302 -0.031932 0 0 0 0 0 0 0 0 0 7.49745 0 0 11.8773 0 10.1672 A0A8I3Q3C2 A0A8I3Q3C2_CANLF Tyrosine-protein kinase (EC 2.7.10.2) SRC Canis lupus familiaris (Dog) (Canis familiaris) bone resorption [GO:0045453]; cell adhesion [GO:0007155]; epidermal growth factor receptor signaling pathway [GO:0007173]; innate immune response [GO:0045087]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoclast development [GO:0036035]; progesterone receptor signaling pathway [GO:0050847] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; signaling receptor binding [GO:0005102] IVNNTEGDWWLAHSLSTGQTGYIP;YLQAFLEDYFT 2 6.5 0.99009 -0.20531 0 0 0 0 0 7.06781 9.28836 0 0 0 0 0 0 0 0 A0A8I3Q3C4 A0A8I3Q3C4_CANLF MAGE family member D1 MAGED1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] LDYRRVPNSN 1 1.3 0.99899 -0.61146 5.14771 0 0 0 0 0 0 0 0 0 9.04933 0 0 0 0 A0A8I3Q3C9 A0A8I3Q3C9_CANLF tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) WDR6 Canis lupus familiaris (Dog) (Canis familiaris) G1 to G0 transition [GO:0070314]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; wobble position ribose methylation [GO:0002130] COP9 signalosome [GO:0008180]; cytosol [GO:0005829]; plasma membrane [GO:0005886] enzyme regulator activity [GO:0030234]; tRNA binding [GO:0000049] CVGDRLLAGEGPDVL;GAGSGSGG;GTLKAVTLAGS;LDHGSGALEPPADP;LSSHRLDEYWDRQRNRHRMVKVDP;LYDPVVGCMLQEV 6 7.6 1.0026 -0.72801 0 0 0 0 0 0 0 10.6098 0 0 0 9.70872 0 0 7.71589 A0A8I3Q3D9 A0A8I3Q3D9_CANLF 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248] "nucleus [GO:0005634]; proteasome regulatory particle, lid subcomplex [GO:0008541]" AGLDEDEDAHVWEDN;EDEDAHVWEDN;EDEDAHVWEDNWDDDNEED;LDEDEDAHVWEDNWDDDNEE;LLEEDDEFEEFPGEDWAGLDEDE 5 55.7 0.86658 0.14389 0 0 0 0 0 0 7.27938 0 0 4.29924 0 0 4.26784 0 0 A0A8I3Q3E6 A0A8I3Q3E6_CANLF Coiled-coil domain containing 194 CCDC194 Canis lupus familiaris (Dog) (Canis familiaris) PRDLAPEVEDLQRR 1 5.9 0.98991 -0.26354 0 0 0 0 0 0 0 0 0 9.11985 0 0 0 0 0 A0A8I3Q3E9 A0A8I3Q3E9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TPSPMETLGP 1 11.1 0.99993 -0.61146 0 0 0 0 0 0 0 0 0 9.82663 0 0 0 0 0 A0A8I3Q3F9 A0A8I3Q3F9_CANLF BCAS3 microtubule associated cell migration factor BCAS3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; response to starvation [GO:0042594] cytoplasm [GO:0005737] PGSPGPIT;QCQQPSVREQPNSNKAGVRDGGRTT 2 3.6 0.97911 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 9.86984 0 0 A0A8I3Q3G0 A0A8I3Q3G0_CANLF Selenoprotein I SELENOI Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylethanolamine biosynthetic process [GO:0006646] membrane [GO:0016020] ethanolaminephosphotransferase activity [GO:0004307] NWLLVPLFLVVLVV;VLFSFILSHWE 2 6.5 0.98477 -0.23792 0 0 0 0 0 0 0 7.34651 0 0 0 0 0 0 0 A0A8I3Q3G1 A0A8I3Q3G1_CANLF Zinc-finger domain-containing protein CDCA7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] ESEVQDVLDHCGFLQK;KFRYVKLIS;LISMETSSSSDDSCDSFASD 3 9.3 1.0028 -0.9799 0 5.96837 10.922 7.672 0 0 0 0 0 0 0 0 0 10.9879 0 A0A8I3Q3G4 A0A8I3Q3G4_CANLF Jumonji domain containing 7 JMJD7 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; methylated histone binding [GO:0035064]; monooxygenase activity [GO:0004497]; peptidyl-lysine 3-dioxygenase activity [GO:0106155] NYSQARALCCTVQAGEMLYLPALWF;VLEGQAQHPG 2 11.1 0.98943 -0.27382 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.40829 A0A8I3Q3H1 A0A8I3Q3H1_CANLF Sp3 transcription factor SP3 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] GAAAATGDLASAQLGGAP;HTGEKKFVC;VEAARDDTL;YVLPLQNL 4 6.1 1.0017 -1.3091 0 0 0 0 10.247 0 0 0 0 0 8.14858 0 0 11.9899 0 A0A8I3Q3H7 A0A8I3Q3H7_CANLF Syntaxin 10 STX10 Canis lupus familiaris (Dog) (Canis familiaris) "Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982] SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905] CAIVVLLGVLLLVLILLF;VVLLGVLLLVLILLF 2 7.2 0.98495 -0.23901 0 0 0 0 0 0 0 0 0 0 4.17528 0 0 0 7.73857 A0A8I3Q3I2 A0A8I3Q3I2_CANLF Microfibril associated protein 5 MFAP5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] LVNEPSTDETVLADIE 1 15.1 0.98258 -0.25112 0 0 9.17138 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q3J9 A0A8I3Q3J9_CANLF MAGE domain-containing protein MAGEE2 Canis lupus familiaris (Dog) (Canis familiaris) PEEYNKALEADKAKER;PEILRRAS 2 4.6 0.98554 -0.44934 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0326 A0A8I3Q3K6 A0A8I3Q3K6_CANLF Synapse differentiation-inducing gene protein 1 (Dispanin subfamily C member 2) (Transmembrane protein 90B) SYNDIG1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of synapse assembly [GO:0051965] dendritic spine [GO:0043197]; intracellular membrane-bounded organelle [GO:0043231]; postsynaptic density membrane [GO:0098839] KIHTLSYDVEEEEEFQELESDYSSD;LDPNTLQQS;SLEYPDGKFIDLSADDIKI 3 19.8 0.99103 -0.20939 0 0 0 0 7.08768 0 0 0 0 0 0 0 0 7.41718 7.61449 A0A8I3Q3L3 A0A8I3Q3L3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EKQREYLICVPNRKS 1 7.3 0.95183 0.053888 0 0 0 0 0 0 9.09903 9.44425 0 0 0 0 0 0 0 A0A8I3Q3L6 A0A8I3Q3L6_CANLF Signal recognition particle receptor subunit beta SRPRB Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794] GTP binding [GO:0005525] IDSMSLKNTP 1 3.7 0.9902 -0.20012 0 0 10.8935 0 0 0 0 0 0 0 0 0 12.6905 0 0 A0A8I3Q3Q3 A0A8I3Q3Q3_CANLF Methionine aminopeptidase (EC 3.4.11.18) METAP1D Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] mitochondrion [GO:0005739] initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] ANDCDLLMEEGMAF;IEVKNEDQIQGLR;SAQFEHTVLITSEGV 3 9.3 0.98855 -0.30814 0 0 12.3568 0 0 11.8936 0 0 0 0 9.34988 0 0 0 0 A0A8I3Q3Q7 A0A8I3Q3Q7_CANLF Uncharacterized protein RETN Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] hormone activity [GO:0005179] IQDDTSSLILETIRN 1 13.8 0.95154 0.053899 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.62518 A0A8I3Q3S1 A0A8I3Q3S1_CANLF PDZ domain containing ring finger 4 PDZRN4 Canis lupus familiaris (Dog) (Canis familiaris) EAKEKASESCSRLSDQDRPSGEQRI;EDFEYEEVELCRVS;WSREERKQ 3 6.1 0.93167 0.096307 0 0 0 0 0 5.25267 0 7.73471 0 0 0 0 0 0 0 A0A8I3Q3S8 A0A8I3Q3S8_CANLF Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) ZCRB1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] KDTRKSKGVAFILFLDK 1 7.8 0.98441 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 4.9472 0 A0A8I3Q3V1 A0A8I3Q3V1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ADYYCQSYDESLGVH;DYYCQSYDESL;QHHPLCVSL;YQQLPGKAPSL 4 18.3 1.0026 -0.71485 0 0 0 0 0 0 0 0 6.71328 0 8.30478 0 8.41223 0 0 A0A8I3Q3V7 A0A8I3Q3V7_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" B4GALT3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; galactosylceramide biosynthetic process [GO:0006682]; protein glycosylation [GO:0006486] cytosol [GO:0005829]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] galactosyltransferase activity [GO:0008378]; metal ion binding [GO:0046872] YRPAGCEPRSRT 1 3 0.98411 -0.24456 0 0 0 0 7.85593 0 0 0 0 0 0 0 0 0 0 A0A8I3Q3W3 A0A8I3Q3W3_CANLF [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) KDM5C Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872] EGSGKDMPKVQGL;LEQVEGYQ;LEVTLDENHSI;LLTIAERWEEKA;VGALQCDLCQDWFHGSP;YHSGFNQGYNFAEAVNFC 6 5.2 1.0021 -1.4419 0 0 0 10.9272 8.57992 0 0 0 0 7.55697 0 9.82236 0 0 10.357 A0A8I3Q3W9 A0A8I3Q3W9_CANLF MMS19 nucleotide excision repair protein MMS19 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654] enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; transcription coactivator activity [GO:0003713] AADGFSLLMSDCTDVLTR;EAPQVMSLHVDTL;GACAQRPVP;IQLLSQVLLQCQSLL 4 4.5 0.98665 -0.40981 0 0 9.44892 0 0 0 0 0 9.05572 0 0 0 0 0 9.87845 A0A8I3Q3X2 A0A8I3Q3X2_CANLF Olfactory receptor OR6B2D Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AMIFMYVRPQ;IDGTPWHSTLLEHNLKK 2 8 0.98927 -0.21817 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.2722 A0A8I3Q3X5 A0A8I3Q3X5_CANLF Melanophilin MLPH Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] GDSEQTDEDGELGTV;NSPKSQGRAADS;QRDFDLRRKEEER;SAHLNETHC;TPAESQIIGLGLSK 5 9.9 1.0032 -1.5651 9.91907 0 0 0 8.36724 0 0 0 0 0 0 9.93736 0 10.2254 0 A0A8I3Q3Y5 A0A8I3Q3Y5_CANLF Ubiquitin domain-containing protein 1 UBTD1 Canis lupus familiaris (Dog) (Canis familiaris) EANDHELAQAILDGASITLP 1 8.8 0.97495 0.048228 0 0 0 0 0 6.28832 0 0 0 0 0 0 0 0 0 A0A8I3Q3Y8 A0A8I3Q3Y8_CANLF "Troponin C, slow skeletal and cardiac muscles" TNNC1 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; regulation of muscle filament sliding speed [GO:0032972]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] cardiac Troponin complex [GO:1990584] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; troponin I binding [GO:0031013]; troponin T binding [GO:0031014] DIYKAAVEQLTEE 1 8.1 0.933 0.068553 0 0 0 0 0 7.57879 0 0 0 0 0 0 0 0 0 A0A8I3Q403 A0A8I3Q403_CANLF Developmental pluripotency associated 3 DPPA3 Canis lupus familiaris (Dog) (Canis familiaris) epigenetic programing of female pronucleus [GO:0044726] nucleus [GO:0005634] methylated histone binding [GO:0035064] QLAAKKAKDPTDH;VQTMSEVLVKNLSKL;VYLSLWSYFPHHLQ;WSYFPHHLQQVEP 4 20.7 0.9886 0.018965 0 0 0 0 0 9.34425 0 0 7.73782 0 0 0 0 0 10.246 A0A8I3Q408 A0A8I3Q408_CANLF ETS transcription factor ELK1 ELK1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; gene expression [GO:0010467]; liver development [GO:0001889]; lung development [GO:0030324] nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; nuclear receptor coactivator activity [GO:0030374]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" GSAQVHIPSISVDGLS;PEVSITSTVAN;VHIPSISVDGLS;VLLTPSSLPPSI 4 9 0.98668 -0.35636 0 0 8.45681 0 0 8.64158 0 0 0 0 0 0 10.5194 10.3154 0 A0A8I3Q414 A0A8I3Q414_CANLF Adducin 3 ADD3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AGIVVDKPPSTMQFED;KCVIHIHTLATA;LNSPNTYMKVN;MPHKERYFDR 4 7.3 0.98755 -0.46826 9.74265 6.19834 0 0 0 0 13.1507 6.59734 0 0 12.2737 7.98971 10.7139 13.0474 7.59619 A0A8I3Q416 A0A8I3Q416_CANLF Dynein regulatory complex protein 9 (IQ domain-containing protein G) IQCG Canis lupus familiaris (Dog) (Canis familiaris) sperm axoneme assembly [GO:0007288] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; manchette [GO:0002177]; sperm flagellum [GO:0036126] calmodulin binding [GO:0005516]; Hsp70 protein binding [GO:0030544] DIIAREEKGKKQ;LKKEQQKLEEKLEFWMEKFDKDTE;NRYMKRNTDLQISQ;VEPLSILDVLRI 4 14.2 0.97401 0.041303 0 0 0 0 0 0 0 4.20938 0 0 0 0 0 0 0 A0A8I3Q418 A0A8I3Q418_CANLF Jade family PHD finger 3 JADE3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] LVRVEDVAA;RYDLDDMDIFWLQELNEDLA;VLERHCHENMNHAIE 3 5.3 1.0021 -0.68771 9.28351 0 0 0 0 0 0 0 4.95652 0 0 0 11.4436 0 0 A0A8I3Q422 A0A8I3Q422_CANLF Eukaryotic translation initiation factor 4E Canis lupus familiaris (Dog) (Canis familiaris) nuclear body [GO:0016604] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] HPLQNRWLSSN 1 6.5 0.97925 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 8.90406 0 A0A8I3Q433 A0A8I3Q433_CANLF RAS like family 10 member A RASL10A Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] GGGRGGRGGPAVTS;GSVTARQQ;HVLRLFRELLRCALVRAR 3 8.6 0.98739 -0.46758 0 0 6.80219 0 9.4433 0 0 0 13.0715 0 0 0 0 0 0 A0A8I3Q490 A0A8I3Q490_CANLF Olfactory receptor OR7R1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LILLIPFLLILLSYAF;LVCMLILLIPFLLI;STCAGHLL;TLIFLLPFCRSHE 4 12.8 0.99099 -0.0028 0 0 0 9.26505 0 0 5.32977 0 5.79616 0 0 0 0 0 8.71346 A0A8I3Q493 A0A8I3Q493_CANLF Visual system homeobox 1 VSX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] TSDEDSPSEDRSGLKASPS 1 8.1 0.95149 0.049806 0 0 0 0 0 0 6.57571 0 0 0 0 0 0 0 0 A0A8I3Q4A0 A0A8I3Q4A0_CANLF Deoxyribonuclease DNASE1L1 Canis lupus familiaris (Dog) (Canis familiaris) DNA catabolic process [GO:0006308] endoplasmic reticulum [GO:0005783] DNA nuclease activity [GO:0004536]; endonuclease activity [GO:0004519] LLLLLLLL;LLLLLLLLL;LLLLLLLLP;PRVQPLGLAALLLLLLLLL;YDRIVLHGER 5 10.2 1.002 -0.90589 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.09202 A0A8I3Q4A3 A0A8I3Q4A3_CANLF Calsequestrin CASQ2 Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; cellular response to caffeine [GO:0071313]; protein polymerization [GO:0051258]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of heart rate [GO:0002027]; sequestering of calcium ion [GO:0051208] sarcoplasmic reticulum lumen [GO:0033018]; Z disc [GO:0030018] calcium ion binding [GO:0005509]; calcium ion sequestering activity [GO:0140314]; calcium-dependent protein binding [GO:0048306] DDDDDDGNNSDEESNDDS;DDDEDDDDDDGNNSDEE;DDDGNNSDEESNDDSDDDD;DDDNEEGDDGDDDEDDDDDD;DDEDDDDD;DDGDDDEDDDDDDGN;DDGDDDEDDDDDDGNN;DDGNNSDEESNDDSDDD;DEDDDDDD;DEESNDDSDDDD;DGDDDEDDDDDDGNN;DNEEGDDGDDDEDDDDDDG;DNEEGDDGDDDEDDDDDDGNN;EDDDDDDGNNSDEES;EDDDNEEGDDGDDDEDDDDDDGNN;EGDDGDDDEDDDD;EGDDGDDDEDDDDDD;EGDDGDDDEDDDDDDGNNSDE;GDDDEDDDDDDGNNSDEES;GDDGDDDEDDDDDDG;GKINTEDDDNEEGDDGDDDED;INTEDDDNEEGDD;LPTAEELEDWI;LSGKVKGDF;NEEGDDGDDDEDDDDDDGNNS;NEEGDDGDDDEDDDDDDGNNSD;NTEDDDNEEGDDGDDDED;VAFAERSDPD 28 14.2 0.93735 0.09985 0 0 5.27131 0 0 0 0 0 5.01252 0 0 0 0 0 0 A0A8I3Q4A4 A0A8I3Q4A4_CANLF NHL repeat containing 2 NHLRC2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] PLREPPLARGRRPPL 1 1.7 0.94964 0.053911 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.17303 A0A8I3Q4A8 A0A8I3Q4A8_CANLF Sodium channel protein SCN11A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] DNFNQQQK;ILRLVRAARGIRTLLFAL;IVRLARIGRILRLVRAARGI;LVTEMKRGPETREE;MWECMQETNQ;NPDYNYTNFDNFG;PFNPIRSLAIKISVHSL;RIVRLARIGRILRLVRAARGIRTLL;SCFEKKNSSEFRMCGIWM;SVTSLIDLK;VFDVIIIILI;VIGKLVVLNLFIALLL;VLRVFKLA 13 8.9 0.99942 -3.0972 0 7.09085 8.70006 6.69516 0 10.9353 0 7.07264 7.34669 0 0 0 0 6.16802 8.17652 A0A8I3Q4B6 A0A8I3Q4B6_CANLF Regulatory factor X-associated protein RFXANK-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASLEDLEDEETHSGGE;GSGGARRRGGG;LVMHPCGGQDDSA 3 11.3 0.98966 -0.53222 0 0 0 0 9.56073 0 0 0 0 0 0 0 8.90764 0 0 A0A8I3Q4D8 A0A8I3Q4D8_CANLF E1A binding protein p400 EP400 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] AKRQEWTEPNSFNVCIAPYKQFFRG;EEEEEEEEEEEEEK;EHVLKCRLSSRQ;HKVVIRLHRVTQPFILRRT;IAPKIARPFIEPLALDSGW;LTAVREWEA;NDLDLEEEEEEEEEEEEEE;PNSFNVCIAPYKQFFRGYASFMR;PPIKPLLG;QFQGNKFT;QHLQGNMMDFLAFKKKHYAPLQAY;QVELEEKRKKALTLQK;REERGRKE;YQVQQLMNRSPVTGQNVNIALQ 14 6.9 0.94959 0.049747 0 0 0 0 0 0 0 0 0 0 4.18816 0 0 0 0 A0A8I3Q4E1 A0A8I3Q4E1_CANLF Pleckstrin homology domain containing S1 PLEKHS1 Canis lupus familiaris (Dog) (Canis familiaris) EHHYMSMKSCFFRETS;GDKRPSSDPSPLFDPSSTLEAVTR;RSLCLSYYKNQHHRGSIKI;TTNREYFLIGHD 4 19.4 0.99401 -0.12138 6.83074 8.41079 0 0 6.77965 6.18228 9.886 6.92148 0 0 7.52513 0 0 0 0 A0A8I3Q4E2 A0A8I3Q4E2_CANLF "MAX interactor 1, dimerization protein" MXI1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" RSTHNELEKNRRAHLRLCLERLKVL 1 11 0.97874 0.035538 7.76699 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q4E7 A0A8I3Q4E7_CANLF Uncharacterized protein GORASP1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] ALLKANVEKPVKLEVFNM;HLHGVQEN 2 6 1.0036 -1.0561 0 0 0 0 0 0 0 0 7.15076 0 0 0 0 0 5.02998 A0A8I3Q4F1 A0A8I3Q4F1_CANLF EGF like domain multiple 6 EGFL6 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] basement membrane [GO:0005604]; membrane [GO:0016020] calcium ion binding [GO:0005509] GVCDWKQDIEDDF;HVEQEQSL;LPDLQAQSNL;NTPGSFKC 4 7 1.0023 -1.4466 0 9.53123 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q4F4 A0A8I3Q4F4_CANLF Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) MBTPS2 Canis lupus familiaris (Dog) (Canis familiaris) bone maturation [GO:0070977]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein maturation [GO:0051604]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976] cytoplasm [GO:0005737]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; transcription regulator activator activity [GO:0140537] ALLGILALVLLPVILLP;GVVHEIGHGIAAI;KDLIGFFILLGGSVLLAANVTLGLW;LVLKSSVYFKHSYEDWLENNGLSIS;QDWNECLDTIA;SSSSSFCIIPSL;VPGINLPVNQLTY;WHNFVLALLGILALVL;YPGAFVDL 9 24.6 1.002 -1.8367 13.2759 0 9.23836 0 5.80944 0 0 0 7.7066 0 0 0 0 13.069 5.68507 A0A8I3Q4F7 A0A8I3Q4F7_CANLF Muscarinic acetylcholine receptor CHRM4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; regulation of locomotion [GO:0040012] postsynaptic membrane [GO:0045211] G protein-coupled acetylcholine receptor activity [GO:0016907] VGKRTVPD 1 1.7 1.0043 -1.1044 0 0 0 4.78283 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q4F8 A0A8I3Q4F8_CANLF Lysine demethylase 1B KDM1B Canis lupus familiaris (Dog) (Canis familiaris) FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; zinc ion binding [GO:0008270] DSVAAPLLSAYYPDCVG;SCGEHFCNE;VLSVGTDQYLL 3 4.5 0.98649 -0.4282 0 0 0 0 0 0 11.2831 0 8.12293 0 0 0 0 0 0 A0A8I3Q4H3 A0A8I3Q4H3_CANLF CHD1 helical C-terminal domain containing 1 CHCT1 Canis lupus familiaris (Dog) (Canis familiaris) MLWRFVSLFSE;RKLPHKTKPKRKRIKE 2 11.5 0.94579 0.084724 0 0 0 0 0 0 0 8.92547 0 0 0 0 5.7498 0 0 A0A8I3Q4H6 A0A8I3Q4H6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) YYDRSRPSGVPDRFSG 1 10.7 0.94125 0.059617 7.95146 0 0 0 0 0 0 0 0 0 0 0 0 0 8.34199 A0A8I3Q4I2 A0A8I3Q4I2_CANLF Tectonic family member 1 TCTN1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] CCCDPDCSSM;CDVNCCCDPDC;DVNCCCDPDCSSMDFS;KYKYGVHLQTSDSF;NCCCDPDCSS;NCCCDPDCSSMD;NSAEAARTTLRPALSPRPPGT;PAQCDVNCCCDPDCSSMDF;PSPLTSSLC;QCDVNCCCDPDCSS;SGNERTVLISTAVTFVDAS;TVMLNQTLVEA;VCDLTPAQCDVNCCC;VHLQTSDSFL 14 17.2 1.0025 -2.1745 0 2.76118 9.40367 0 8.02497 9.24451 5.50985 0 7.36763 9.55674 9.31587 10.1902 0 0 9.12239 A0A8I3Q4J2 A0A8I3Q4J2_CANLF Voltage-dependent L-type calcium channel subunit alpha CACNA1C Canis lupus familiaris (Dog) (Canis familiaris) dendrite [GO:0030425]; perikaryon [GO:0043204]; postsynaptic density membrane [GO:0098839]; T-tubule [GO:0030315]; voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AFRVLRPLRL;AINVVKILRVLRVLRP;ATGEAWQDIMLACMPG;DIDPENEDEGMDEEKPRNM;GIQSSAINVVKILRVLRVLR;INVVKILRVLRVLRPLRA;NRNNNFQTFPQAV;PGAALSWQAAIDAARQAKLM;QHQYKVWYVVN;RVEISIFFIIYIIIIAF;SETESVNTENVAG;TQELADACDMTIEEMENAAD;VIFGSFFVLNLV;VLRVLRPLRAINRAKG;VMLFFIYAVIGMQVFG;VVQCVFVAIR 16 9.7 1.0023 -1.2458 5.55431 0 9.84493 7.14486 0 0 0 0 9.28921 0 4.7981 12.3054 0 0 11.292 A0A8I3Q4J3 A0A8I3Q4J3_CANLF Uncharacterized protein NANOG Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" HSWNSQTWCPQAWNNQAWNNP;SSQAWNNPNWSSQ 2 11.2 0.99324 -0.18735 0 0 0 0 0 0 0 0 0 0 0 0 6.70155 7.30076 0 A0A8I3Q4J4 A0A8I3Q4J4_CANLF Ankyrin repeat and LEM domain containing 1 ANKLE1 Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519] EERREEGLGGPLLT;LLMDPRETQ;PDIQSSQRMPRS 3 4.7 1.0038 -1.054 0 0 0 0 0 0 9.24 0 0 0 0 0 0 10.9379 0 A0A8I3Q4K8 A0A8I3Q4K8_CANLF Uncharacterized protein IGSF5 Canis lupus familiaris (Dog) (Canis familiaris) AIVLLAVSLSLLLILIIILI;AIVLLAVSLSLLLILIIILIII;EINLKSGSENSAYSPDEPRTA;IVLLAVSLSLLLILIIILIII;LAVSLSLLLILIIILI;LIIIFCCCYISGKEKKES;LLAVSLSLLLILIIILI;LLAVSLSLLLILIIILII;LLAVSLSLLLILIIILIII;LSLLLILIIILIIIFC;NLTVVQPS;SLSLLLILIIILIIIF;VLLAVSLSLLLILIIILIII 13 17.6 0.89186 0.12475 0 6.11566 6.557 2.64323 7.44112 2.00281 4.62959 6.07664 9.08956 0 7.72731 7.01581 8.49185 8.37751 5.6339 A0A8I3Q4M8 A0A8I3Q4M8_CANLF Uncharacterized protein FAM216A Canis lupus familiaris (Dog) (Canis familiaris) PTAVAGTE;STNDSESYMNEE 2 7.9 0.99118 -0.54631 0 0 0 0 9.09424 0 0 0 9.67154 0 0 0 0 0 0 A0A8I3Q4N2 A0A8I3Q4N2_CANLF Hyccin PI4KA lipid kinase complex subunit 2 HYCC2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GASLSSQPIGTKPSSSSQR;GVVEEWLSEFKAL;GVVEEWLSEFKALPDTQI;ITTASIRRHRWRREGAEGVN;TISLQEDRLGQAGEG;YSTISLQEDRLGQAGE 6 14.7 0.9639 0.048688 0 0 0 7.1822 0 0 0 0 0 0 0 0 7.55811 0 0 A0A8I3Q4R8 A0A8I3Q4R8_CANLF Haloacid dehalogenase like hydrolase domain containing 5 ADA2 Canis lupus familiaris (Dog) (Canis familiaris) SNGNPGTG;SPGLMEASHIVND 2 4.6 0.98871 -0.20414 0 0 0 0 0 0 0 10.5762 0 0 0 0 0 0 9.50273 A0A8I3Q4S1 A0A8I3Q4S1_CANLF isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) IARS2 Canis lupus familiaris (Dog) (Canis familiaris) isoleucyl-tRNA aminoacylation [GO:0006428] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049] AARNFWARPR;AEEVFQHVPYAKE;ATAKELLK;ESSYKVIVMPT;FNPETDSIPVNNMHVID;HIGHALNKILKDIANRYHM;KDIANRYH;VLPGTDQRADLYLE 8 8.9 0.99822 -3.3043 0 0 0 0 9.88214 13.0778 7.91265 10.7271 14.1801 6.66406 9.08095 0 0 9.65569 0 A0A8I3Q4S2 A0A8I3Q4S2_CANLF Synaptopodin 2 SYNPO2 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] EAGDTGLP;ESASTSYFVA;GTGELERQAHEEEEEEEEGDKEE;PVGIPTSPKQESAS;YVEVSRGLGQLPQQ 5 5.9 1.002 -1.4635 8.93174 0 8.69561 8.63267 0 10.8365 8.92662 0 0 9.07839 0 0 0 0 0 A0A8I3Q4S5 A0A8I3Q4S5_CANLF Uncharacterized protein MCFD2 Canis lupus familiaris (Dog) (Canis familiaris) LCWDWPAGEG;SPQELQLHYFKMHD;VGLDKNTVHDQ 3 17.5 0.9992 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.17597 A0A8I3Q4S6 A0A8I3Q4S6_CANLF Uncharacterized protein CHIC1 Canis lupus familiaris (Dog) (Canis familiaris) EDEEEEEDEEEEEEETPPP;EEETPPPPRVVSEEHL;PDDDEEDEEDEEEEEDEEE;PDDDEEDEEDEEEEEDEEEEEEE 4 18.3 0.84267 0.19431 5.22886 0 0 5.73211 5.55311 0 0 8.32486 0 0 4.55127 0 0 0 0 A0A8I3Q4S8 A0A8I3Q4S8_CANLF thioredoxin-disulfide reductase (EC 1.8.1.9) TXNRD2 Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979] flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] EATSVPHIY;EPSPRGTKWGLGGTCVN;MSSLVTEYMT;PITGDRAACPLEI;RVRRLPDGQL;VEVYHAYYKPLE 6 13.2 1.0029 -2.1877 9.30608 8.48933 0 0 0 0 9.06848 0 0 0 8.82493 8.72622 0 9.02992 0 A0A8I3Q4T5 A0A8I3Q4T5_CANLF FAM21/CAPZIP domain-containing protein LOC119868814 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; plasma membrane [GO:0005886] DDDDDDDDDFF;DEDEESDLFT;EDDDGCDIFADSEKEE;EEEDDDGC;GVFQDEELLFSHK;LSSEGILFDEEEDDDGCDI;PAKSQPLISEKKRLVK;VEGAVESSEL 8 7 0.94988 0.04975 0 0 0 0 0 0 0 0 0 0 0 0 10.8865 0 0 A0A8I3Q4T6 A0A8I3Q4T6_CANLF Osteocrin OSTN Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; endochondral bone growth [GO:0003416]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of dendrite extension [GO:1903860]; negative regulation of glucose import [GO:0046325]; negative regulation of osteoblast differentiation [GO:0045668] extracellular space [GO:0005615] signaling receptor binding [GO:0005102] HSVDVATEAF 1 7.6 0.98812 -0.26075 9.58916 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q4V3 A0A8I3Q4V3_CANLF Discs large MAGUK scaffold protein 1 DLG1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; receptor clustering [GO:0043113] basolateral plasma membrane [GO:0016323]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; postsynaptic density membrane [GO:0098839] kinase binding [GO:0019900] GGAAAQDGRLRVNDCI;VGPKQKHWAKKGSSD 2 3.9 0.9479 0.054534 0 0 0 8.74201 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q4W0 A0A8I3Q4W0_CANLF Coiled-coil domain containing 32 CCDC32 Canis lupus familiaris (Dog) (Canis familiaris) head development [GO:0060322]; regulation of clathrin-dependent endocytosis [GO:2000369] clathrin-coated pit [GO:0005905] LEKKLRRIKGL 1 6.1 0.9847 0.035491 0 0 0 0 0 5.80859 0 0 0 0 0 0 0 0 0 A0A8I3Q4Y0 A0A8I3Q4Y0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) WKDTTERQ 1 9 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 8.3637 0 0 A0A8I3Q4Z1 A0A8I3Q4Z1_CANLF DS cell adhesion molecule DSCAM Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060] dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202] cell-cell adhesion mediator activity [GO:0098632]; netrin receptor binding [GO:1990890]; protein tyrosine kinase binding [GO:1990782] AFTRAGDGVRSE;GVLLLFVLLLVVRRRRREQR;GVLLLFVLLLVVRRRRREQRLK;HLKGNNPYAKSYT;ILVGVLLLFVLLLVVRR;ISCILVGVLLLFVLLLVVRRRRR;MLMSKNTRT;NISSSQVRDGGV;QWQQGTVATLPQRE;SPAVKWMKDSNGTPSLVTIDG;TAKVIGRLY;VGADVSKSMYL;VGVLLLFVLLLVVRRRRRE;VLLLFVLLLVVRRRR;VLLLFVLLLVVRRRRRE;VLLLFVLLLVVRRRRREQRLKR;VLLLVVRRRRREQRLKRLRDAKSL;YVTVVSWEKD 18 7.3 1.003 -1.0314 0 7.95838 10.3534 8.35204 0 11.4145 6.41393 0 0 9.03881 9.57658 0 7.41083 7.6923 0 A0A8I3Q4Z7 A0A8I3Q4Z7_CANLF KIAA1671 KIAA1671 Canis lupus familiaris (Dog) (Canis familiaris) DNAWMFKDSTEEK;EPSPQWLKE;GVRTQASFAEANHS;GVSVQERI;LEEKAMTLRSSRS;LVSLNHEEPLEAKGSN;PVNYRGESSV;QDLEKEDALQDKEQPLW;SEAISTALEEKAMT;TEKWGWTALSNG;VGPGMARTW;VGSLTSLTGV;VGSVQRVSLI 13 8.1 0.99699 -3.6728 8.7361 13.2314 0 0 8.62297 13.1374 11.2963 0 0 0 0 0 5.94965 0 0 A0A8I3Q501 A0A8I3Q501_CANLF Chromatin modification-related protein MEAF6 MEAF6 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] kinetochore [GO:0000776]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730] SQEDPEDLDGSVQGV 1 8.3 0.92616 0.095934 0 0 0 18.9326 0 0 0 0 0 20.1674 0 19.8753 20.2934 0 0 A0A8I3Q514 A0A8I3Q514_CANLF Zinc finger protein 630 ZNF630 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CMECGRAFSLKSHL;PGIIFKLEHEEDPWIKKSE;YSDSCSVPEKIYTGMKP 3 7.6 0.85285 0.15674 0 0 0 6.66846 0 0 0 0 0 8.24522 8.86487 0 0 0 0 A0A8I3Q522 A0A8I3Q522_CANLF Uncharacterized protein FLNA Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] intracellular non-membrane-bounded organelle [GO:0043232] actin filament binding [GO:0051015] AEIVEGENHTY;AKHGGKAA;AVRDVDIIDHHDNTYTVK;EHLKCVSK;LAEDAPWKKIQ;LHSVDVTYDGSPV;LPTHDASKV;LVSAYGAGLEGGVTGSPA;NVGAGSHPN;PMAPGSYL;QQGPVGINVTYGGDPIP;VDVVENEDGTF;YTVTITWGG 13 5.7 1.0017 -2.646 7.79585 12.7334 11.4179 9.48049 0 0 3.82049 8.18874 11.2786 9.94182 0 11.2897 12.5859 11.5371 2.9119 A0A8I3Q523 A0A8I3Q523_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] PDESNARYFHVVIA;VESFLQEKAC 2 16.9 0.99203 -0.55036 0 0 0 0 10.2581 0 0 0 0 0 0 0 0 0 8.48732 A0A8I3Q524 A0A8I3Q524_CANLF Polyadenylate-binding protein (PABP) PABPC1 Canis lupus familiaris (Dog) (Canis familiaris) "CRD-mediated mRNA stabilization [GO:0070934]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of viral genome replication [GO:0045070]" catalytic step 2 spliceosome [GO:0071013]; cell leading edge [GO:0031252]; cytoplasmic stress granule [GO:0010494]; mCRD-mediated mRNA stability complex [GO:0106002] mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266] GGGVEVGGVG;GGGWGVGG;NPQQHLNAQPQ;VGGGGGGV;VGWGGGGG;WGGWGGGG 6 5 0.98693 -0.50271 7.35147 0 0 0 0 0 0 0 10.2816 0 0 0 0 0 0 A0A8I3Q525 A0A8I3Q525_CANLF "phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153)" PIK3CD Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation of cell migration by vascular endothelial growth factor signaling pathway [GO:0038089]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031] "cytoplasm [GO:0005737]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005] DSLRDPEVNDFRTKMRQ;FKNGDDLRQDMLT;QPFLPVLRLVAR 3 4 0.93064 0.096667 0 0 0 0 0 0 0 6.33119 0 0 0 0 8.26242 8.09756 0 A0A8I3Q526 A0A8I3Q526_CANLF BCL2 like 13 BCL2L13 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] membrane [GO:0016020] DCLAHLGEKVSQELK;EVIPVLEPSETLLS;TLLVELGEEENLMKTKAA 3 10.1 0.98674 -0.41904 0 0 0 0 0 0 0 9.33222 9.03681 0 0 0 0 0 0 A0A8I3Q528 A0A8I3Q528_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) MARCHF5 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140] mitochondrial outer membrane [GO:0005741] ubiquitin protein ligase activity [GO:0061630] EDYVLRLWRKYSNK;SIYWTAVTY;VMERADPLFLLIGL 3 21.3 0.99419 -0.12268 0 0 0 0 0 0 9.49229 0 10.8463 0 4.32747 0 0 0 0 A0A8I3Q543 A0A8I3Q543_CANLF ABC transmembrane type-1 domain-containing protein LOC119869278 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; very long-chain fatty acid catabolic process [GO:0042760] peroxisomal membrane [GO:0005778] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; long-chain fatty acid transmembrane transporter activity [GO:0005324] ESEWNMDRWVPGWQ;SEWNMDRWVP 2 5.6 0.9921 -0.55035 7.73444 0 0 7.52755 0 0 0 0 7.94287 0 0 0 0 0 7.65928 A0A8I3Q548 A0A8I3Q548_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) QVSGSLGQR;YQQLPGKAPKLLI 2 17.6 1.0038 -1.041 0 8.43642 8.73843 0 0 0 0 0 0 0 9.85929 0 0 0 0 A0A8I3Q558 A0A8I3Q558_CANLF Solute carrier family 16 member 12 SLC16A12 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] transmembrane transporter activity [GO:0022857] CLKNYQYVCYLFAVGLDGLCYLCL;LVPFSCTFGYFDGAYVTLIPVVT 2 10.6 0.94462 0.087678 9.09482 0 0 0 0 0 0 0 9.35509 0 0 0 0 0 0 A0A8I3Q562 A0A8I3Q562_CANLF Acyltransferase (EC 2.3.1.-) DGAT2L6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] PLSYLAMFWIL;VDKYHALYMDALCKLFDQHKTQYG 2 10 0.99532 -0.56366 0 0 0 0 0 0 0 0 0 9.98428 0 0 0 0 0 A0A8I3Q569 A0A8I3Q569_CANLF Carbonic anhydrase (EC 4.2.1.1) CA5B Canis lupus familiaris (Dog) (Canis familiaris) carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] EDNYRLKQFHFHWGA;EFGSFDPSCLMPA;GEKEKRMVDNFRPL;GSFDPSCLMPACPDYWTYSG;WRRFQIPTFMPARPCSLYTCTYK 5 25.5 0.9933 -0.04828 0 8.91334 8.98334 0 0 0 0 0 0 0 9.9847 9.15411 0 0 0 A0A8I3Q586 A0A8I3Q586_CANLF Heparanase 2 (inactive) HPSE2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] FQNLRNPAKSRGGPGPDYY;INLHRSRKKIKL;LFIINLHRSR;LFIINLHRSRKKIKLAG;LPVDRAPGLKEKTLILLDVSTK;LVDQNFNPLPD;PKVLAVHV;QKVVNTYTPGKK 8 18.5 1.0031 -0.83828 7.48502 12.2177 0 0 8.35363 0 0 7.96284 0 0 0 11.3555 6.03547 0 5.38004 A0A8I3Q591 A0A8I3Q591_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VGTFTGIY 1 7.8 1.0041 -1.1044 0 0 0 0 0 0 0 0 6.30767 0 0 0 0 0 0 A0A8I3Q592 A0A8I3Q592_CANLF Endonuclease/exonuclease/phosphatase family domain containing 1 EEPD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] catalytic activity [GO:0003824]; DNA binding [GO:0003677] EALEKGAGFSGFLW;KEKFYHLV 2 4.1 1.0027 -1.3544 0 0 0 0 0 9.71593 0 0 0 0 0 0 10.3159 0 0 A0A8I3Q594 A0A8I3Q594_CANLF "Collectrin, amino acid transport regulator" CLTRN Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GVIFCIVIVAVVL;PDAENAFKVRLSI 2 11.7 0.92085 0.11931 0 0 3.73097 0 9.80835 0 0 0 0 0 0 0 0 0 0 A0A8I3Q5A9 A0A8I3Q5A9_CANLF Transcription elongation factor A N-terminal and central domain containing TCEANC Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DEEMMTYVI;EDLGNHLTDLETL 2 6.3 1.0018 -0.74435 0 0 0 0 0 0 5.61742 0 0 0 0 0 0 0 7.74052 A0A8I3Q5B6 A0A8I3Q5B6_CANLF Malectin MLEC Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] oligosaccharyltransferase complex [GO:0008250] carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899] AAVALLRLLLLL;ALLRLLLLLLLPALR;GAAVALLRLLLLLLLPALRG;LDIFDRVGHSTAHDEI;LLLLLLLP;LRLLLLLLLPALRGPG;RLLLLLLL;VALLRLLLLLLL 8 13.1 0.65882 0.3144 10.9061 0 4.22674 5.19105 0 0 0 0 0 0 0 0 0 0 6.4469 A0A8I3Q5B9 A0A8I3Q5B9_CANLF Aristaless related homeobox ARX Canis lupus familiaris (Dog) (Canis familiaris) axon guidance [GO:0007411]; cell proliferation in forebrain [GO:0021846]; cerebral cortex GABAergic interneuron migration [GO:0021853]; cerebral cortex tangential migration [GO:0021800]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; epithelial cell fate commitment [GO:0072148]; globus pallidus development [GO:0021759]; lipid digestion [GO:0044241]; organ growth [GO:0035265]; positive regulation of gene expression [GO:0010628]; positive regulation of organ growth [GO:0046622]; regulation of epithelial cell proliferation [GO:0050678] nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEEDEDEEEELLEDDEEE;DRSPLPAGS;EAELHPPP;EDEDEEEE;GAEDDEEELLEDEEDEDEEE;GPGGAAHP;LDELGGPG;PLSPYLDASPFPPHHP 8 13.2 1.0031 -1.6682 8.82852 0 0 0 0 0 0 8.1396 7.8515 0 9.27184 10.6123 5.44738 5.32603 5.09727 A0A8I3Q5C5 A0A8I3Q5C5_CANLF NK2 homeobox 3 NKX2-3 Canis lupus familiaris (Dog) (Canis familiaris) "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; gland morphogenesis [GO:0022612]; leukocyte homeostasis [GO:0001776]; leukocyte migration [GO:0050900]; lymph node development [GO:0048535]; macrophage differentiation [GO:0030225]; odontogenesis of dentin-containing tooth [GO:0042475]; Peyer's patch development [GO:0048541]; plasma cell differentiation [GO:0002317]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic digestive tract morphogenesis [GO:0048621]; regulation of epithelial cell proliferation [GO:0050678]; spleen development [GO:0048536]; transcription by RNA polymerase II [GO:0006366]; triglyceride metabolic process [GO:0006641]" nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" AAGAACAQ;GAACAQGT;GGGGGGGA;GGGGGGGG;PKPRSRRKPRVLFS;VTPGAQAYGAPYSVGAG 6 14 0.98654 -0.42484 5.13118 0 0 0 0 7.99243 8.92567 0 0 0 8.0167 8.37221 0 0 0 A0A8I3Q5C6 A0A8I3Q5C6_CANLF Uncharacterized protein PRAME Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell population proliferation [GO:0008284] LHLGRLAH;VLIDLCLK 2 3.1 1.0035 -1.6165 0 0 0 0 0 4.63686 0 0 0 0 0 0 0 0 0 A0A8I3Q5D1 A0A8I3Q5D1_CANLF Uncharacterized protein CST7 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; negative regulation of microglial cell activation [GO:1903979]; positive regulation of myelination [GO:0031643] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; multivesicular body [GO:0005771] cysteine-type endopeptidase inhibitor activity [GO:0004869]; protein homodimerization activity [GO:0042803] PSLDNCDF 1 5.6 1.004 -1.1044 0 0 4.75793 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q5D9 A0A8I3Q5D9_CANLF Procollagen C-endopeptidase enhancer 2 PCOLCE2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830] collagen binding [GO:0005518]; heparin binding [GO:0008201]; peptidase activator activity [GO:0016504] ESNYCSSN;FFCSVGWHCDHNCH;GVTCMWHIVA;LTFAFPVILFPNV;SSGNKMMVQMISDA;TLESNYCS 6 15.2 1.0022 -1.8729 9.81131 0 0 0 0 0 0 0 10.8807 0 0 10.925 0 0 5.58538 A0A8I3Q5E7 A0A8I3Q5E7_CANLF Uncharacterized protein MAP7D1 Canis lupus familiaris (Dog) (Canis familiaris) SPTPAQPQKEQPTAIPAAPAPTP 1 4.1 0.97685 0.046444 0 0 0 9.79355 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q5F7 A0A8I3Q5F7_CANLF Alpha-centractin ACTR1A Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; centrosome [GO:0005813] IHEVLVFAIQKSDMD;IVKDWNDMERIWQYVYSKDQLQ 2 11.1 0.98343 -0.25548 0 0 0 0 0 0 9.85297 0 0 0 0 0 0 0 0 A0A8I3Q5H0 A0A8I3Q5H0_CANLF POC1 centriolar protein homolog A DUSP7 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; spindle pole [GO:0000922] CEDCWPEVDFPVPP 1 2.6 0.93254 0.060769 0 0 0 0 5.38736 0 0 0 0 0 0 0 0 0 0 A0A8I3Q5H2 A0A8I3Q5H2_CANLF Gastrin releasing peptide receptor GRPR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528] INGNICHEGSQRSCCWRVA 1 4.8 0.95231 0.049882 0 0 0 0 0 0 0 0 0 0 0 10.2842 0 0 0 A0A8I3Q5H3 A0A8I3Q5H3_CANLF Transcription factor 7 like 2 TCF7L2 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; maintenance of DNA repeat elements [GO:0043570]; myoblast fate commitment [GO:0048625]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hormone metabolic process [GO:0032350]; regulation of smooth muscle cell proliferation [GO:0048660] beta-catenin-TCF7L2 complex [GO:0070369]; chromatin [GO:0000785]; nucleoplasm [GO:0005654] armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; gamma-catenin binding [GO:0045295]; nuclear receptor binding [GO:0016922]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] KDEGEQEE;PAALQPPVLPS;PQPQPQPQPQPQPQPQPLS;PRSESFRDKSRESLE;QPQPQPQPLSL;VSNKVPVVQHPHH 6 9.4 1.0024 -1.7569 0 8.6878 13.5401 10.5675 0 0 12.3114 12.6835 12.3089 12.0716 0 0 0 5.51355 0 A0A8I3Q5H8 A0A8I3Q5H8_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042]; exocytosis [GO:0006887] cytoskeleton [GO:0005856] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] ADVHWTHIRERE;ASKSFGPGHEEDEEEEEYEEEEEE;DEQNVEKNNQ;EDEEEEEYEEE;EDEEEEEYEEEEEEEEEEY;EDEEEEEYEEEEEEEEEEYEEEE;EDEEEEEYEEEEEEEEEEYEEEEEE;GEAGMGKKDDPKL;HEEDEEEEEYEEEEEEEEEEYEEEE;QLSFSEDSDLSSDD;STSRVPFDENDLEED 11 4.9 0.98598 -0.4518 0 0 10.309 9.74751 5.71284 0 8.65789 0 0 7.17951 0 0 6.69042 3.46454 0 A0A8I3Q5K2 A0A8I3Q5K2_CANLF Cadherin EGF LAG seven-pass G-type receptor 3 CELSR3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ALAPRGAGAGAAGPWFSSE;ASASTLFRPI;GDFCETEL;HYLHAALSGLQVPGTPSHPGPG;ILQLRATDGDAP;ILVIVVSVFTQ;LAVFTHVVMAV;NEKHDFLALE;PTCGPCNCD;RMRSRALFRRRFL;RPHTVVLRVTAT;RWHDLRLELQEEPGGRR;TGHTEHYF;VGGTVLNVS;VGLVTPNISMEEIP 15 6.6 1.001 -2.7226 12.8367 10.9324 5.94028 7.88984 9.1047 0 10.9715 0 9.41075 0 0 10.919 0 0 10.5575 A0A8I3Q5K9 A0A8I3Q5K9_CANLF REST corepressor 2 RCOR2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] enzyme binding [GO:0019899]; transcription corepressor activity [GO:0003714] GPGCPGAG;VGTNYQAVIPECKPESPA;YRRRFNLE 3 6.1 1.0046 -1.0535 0 0 0 0 0 8.55953 0 0 0 0 0 8.86567 0 0 0 A0A8I3Q5N7 A0A8I3Q5N7_CANLF Scm polycomb group protein like 2 SCML2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] EKEGDLLQPPLGYQMNA;IVMSTVCVYVNKHGDSGP;VLKQGFSKDPSTWSVDEVIQF 3 8.2 0.9863 -0.41673 0 0 0 0 12.6465 0 0 9.86346 0 0 0 0 0 0 8.82975 A0A8I3Q5P9 A0A8I3Q5P9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ASAKLTCTLSSEHSSYYIYWYQQQQ;IQSEDEADYYCGAPA 2 29.9 0.93677 0.089419 0 0 0 0 0 0 0 0 0 8.36151 0 0 0 0 8.43359 A0A8I3Q5Q2 A0A8I3Q5Q2_CANLF Potassium inwardly rectifying channel subfamily J member 10 KCNJ10 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] HSDSGSIQI;LVPLRAEPRRPRLAPLAP;QLGASLLPAPSVRPAAH;TWHPGRTQGGEGGG;VGPGVRRRRVLTK 5 9.9 0.98805 -0.34065 0 0 0 8.93967 0 0 4.25437 7.56232 0 0 0 0 0 9.40024 7.85879 A0A8I3Q5Q6 A0A8I3Q5Q6_CANLF Coiled-coil domain containing 63 CCDC63 Canis lupus familiaris (Dog) (Canis familiaris) LRLLKLTKDGNLNQ;RYEKAAYDNAYQKLQ 2 5.2 0.99388 -0.17255 0 0 0 0 0 0 0 0 0 0 0 0 0 3.93007 10.0863 A0A8I3Q5R2 A0A8I3Q5R2_CANLF Multiple inositol-polyphosphate phosphatase 1 MINPP1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] HGTRYPTAKQIRRLRQLHGLLQ;RGAGGGAG 2 7.8 0.97458 0.046883 0 0 0 0 0 0 0 0 5.09542 0 0 0 0 0 0 A0A8I3Q5R8 A0A8I3Q5R8_CANLF ATPase 13A3 ATP13A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type ion transporter activity [GO:0015662] ALVKENGSCQIIT;LVSIMVENF;TCIVNESMLTGESV;VIASLCKPETVPV 4 4 1.0026 -1.143 0 9.35894 0 11.4468 0 0 10.4453 0 0 0 0 0 11.1808 0 0 A0A8I3Q5R9 A0A8I3Q5R9_CANLF Zinc finger protein 26 ZNF26 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GIHTGNNPYQCSECG;IVHQEIHTGGKP;PDKFHGYEESYF 3 7.4 0.98738 -0.46638 0 0 0 0 0 0 0 8.33163 9.97556 0 0 0 10.7156 0 0 A0A8I3Q5S8 A0A8I3Q5S8_CANLF Pro-epidermal growth factor EGF Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] GNYTCMCAGSL;IPGSYYCTCP;NLDGSKRQRLAQNDVGHPFA;PGSVKRTSWRNEHQLYK;SWRNEHQLYKDT;WAPDQKLCKWKQGNCR;WNHGCTLGCENIPGSYYCTC 7 7.5 1.003 -1.5834 9.36752 0 0 0 0 0 0 0 9.79217 0 11.6416 8.45566 4.77299 0 0 A0A8I3Q5V1 A0A8I3Q5V1_CANLF Peroxiredoxin 4 PRDX4 Canis lupus familiaris (Dog) (Canis familiaris) antioxidant activity [GO:0016209]; oxidoreductase activity [GO:0016491] HHSKAKIS 1 3.1 1.004 -1.1044 0 0 0 0 0 0 0 6.31227 0 0 0 0 0 0 0 A0A8I3Q5V2 A0A8I3Q5V2_CANLF Alpha-2-macroglobulin like 1 A2ML1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] ANRLVLQQETLPSIPGVY;DVVEPKQLSTVE;EFIFIDDK;ITFEDTKNFYYPNF;NKNFQHTFSI;NYLKDCIRVQ;TAYITAALLE;TVGLTAFKPFF;VVALQALAKYATAA;YRMFSFWYGHYPYQV 10 8.4 0.98631 -0.25963 0 0 0 0 0 0 0 0 0 0 0 0 0 11.5126 0 A0A8I3Q5W3 A0A8I3Q5W3_CANLF Transgelin TAGLN2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] actin cytoskeleton [GO:0015629] actin filament binding [GO:0051015] FQNWLKDGTVLCELINGLYPE;VGEAEGCS 2 9.6 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 5.07921 0 0 0 0 0 A0A8I3Q5W5 A0A8I3Q5W5_CANLF Catechol O-methyltransferase (EC 2.1.1.6) COMT Canis lupus familiaris (Dog) (Canis familiaris) catecholamine metabolic process [GO:0006584]; methylation [GO:0032259] plasma membrane [GO:0005886] catechol O-methyltransferase activity [GO:0016206]; magnesium ion binding [GO:0000287] AALSLGLVLLVLLCLRHL;TVLLADNVICP 2 10.8 0.98027 0.048313 0 6.10343 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q5X1 A0A8I3Q5X1_CANLF UAP56-interacting factor (Forty-two-three domain-containing protein 1) Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] nucleoplasm [GO:0005654] mRNA binding [GO:0003729] ESNRIESN;PVTQKPRLTRT 2 6.4 1.0037 -1.0689 0 0 0 0 0 0 0 0 7.63256 0 0 7.22014 0 0 0 A0A8I3Q5Z1 A0A8I3Q5Z1_CANLF "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1" PFKFB1 Canis lupus familiaris (Dog) (Canis familiaris) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex [GO:0043540]" "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" NFIQSQGINSL;VGTRYMVNRVQDHIQSRTVYYLM 2 8.4 0.94414 0.081767 0 9.21077 0 0 0 0 10.3492 0 0 3.46074 3.30973 0 0 3.43429 3.99594 A0A8I3Q600 A0A8I3Q600_CANLF UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 LOC607011 Canis lupus familiaris (Dog) (Canis familiaris) uridylyltransferase activity [GO:0070569] GVVCQADGVPQVVEY;VIMFEQRMLPAVNFDG 2 6.2 0.94012 0.10312 0 0 0 0 7.65914 0 0 0 0 0 0 0 7.26407 0 0 A0A8I3Q606 A0A8I3Q606_CANLF AarF domain containing kinase 2 ADCK2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ubiquinone biosynthetic process [GO:0010795] mitochondrion [GO:0005739] AGIPVDLKKKIARLGINMLLK;DLKKKIARL;LNVNSVKFPTPLRPFV;VAVKVLHPGL 4 7.5 1.0032 -1.0263 5.87544 0 0 5.51995 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q615 A0A8I3Q615_CANLF Prolactin releasing hormone receptor PRLHR Canis lupus familiaris (Dog) (Canis familiaris) feeding behavior [GO:0007631]; hormone metabolic process [GO:0042445] cilium [GO:0005929]; membrane [GO:0016020] neuropeptide Y receptor activity [GO:0004983] AAVHTYHVEL;LSDVLMCTAC;VLVIARVRRLH 3 8.4 1.0031 -0.89394 0 0 0 10.8004 0 0 0 0 0 0 0 0 0 0 3.98468 A0A8I3Q646 A0A8I3Q646_CANLF Clarin 3 CLRN3 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of sound [GO:0007605] membrane [GO:0016020] AATYGGATHSYGY;LVILLNVVTVVIIFFFQ;LVTILFLVLSLCASLLSSGL 3 21.8 0.98967 -0.51699 0 0 11.3008 0 6.3627 0 0 0 0 0 0 0 0 0 0 A0A8I3Q654 A0A8I3Q654_CANLF 60S ribosomal protein L31 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] AINEVVTREYPIN 1 11 0.94015 0.070297 0 0 0 0 0 0 0 0 0 0 5.7941 0 0 0 0 A0A8I3Q668 A0A8I3Q668_CANLF Ryanodine receptor 3 RYR3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AWKEILNLLYKLLAALIR;CCRFLCYFCRISRQNQKAMFEH;EEEEDEDSSYMLEIE;EEEEEDEDSSYM;EGTREKVLQNDEFTR;GGEGWGGNGVGDDLYSYGF;GLGDIMNNKVFY;IEECLLAICNH;IISTVDYL;IRNTTALFSQF;KLLLVLPLVLPA;LINDVTSIRPNIFLGVAEGSAQYKK;LSVSNGNIQ;LVPYALLDEPTKKSNRDS;NALTERRSGKLPEKKLIFPYLIF;NGNIQVDASFMQTLWNVHP;NILKIINN;PEEEEEEDEDSSYMLEIEG;QCLEPLQMMALH;SEIIGKDEP;SHKKYDPD;VDVLELCEQEDLMYFHYHTLR;VFHLEQCAPTCVISVQV;YHILCSLYSLGTGKNIYVER;YMLEIEGEEEDS 25 7 0.87101 0.14292 0 0 0 0 0 3.36835 0 0 0 0 0 6.2107 0 7.1812 9.69733 A0A8I3Q672 A0A8I3Q672_CANLF Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Protein kinase minibrain homolog) DYRK1A Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; transcription coactivator activity [GO:0003713] EWVAIKII;IVDFGSSCQLGQRIYQY;SDRRQPNINDQQVSALSYSDQIQQP 3 9.6 1.002 -0.69137 12.2154 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q685 A0A8I3Q685_CANLF RNA helicase aquarius AQR Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013] helicase activity [GO:0004386]; RNA binding [GO:0003723] EVQIIKNMPQMANFVYNMYMHL;HGEEELET;TIQFTHTQIEA 3 3 1.0034 -1.6169 10.482 0 0 8.10108 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q687 A0A8I3Q687_CANLF Solute carrier family 24 member 3 SLC24A3 Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628] plasma membrane [GO:0005886] "calcium, potassium:sodium antiporter activity [GO:0008273]" AGLRIMIT;DVVAEAGNETENENEDNENNEND;EAGNETENENEDNENNENDEEEE;EDNENNENDEEEEEDEDDD;EEEEEDEDDDEG;ENENEDNENNENDEEEEEDEDD;IVARQGMGDMAV;LHLSEDVAGATFMAAG;NEDNENNENDEEEEEDEDDDEGP;TEPALHEFPNDIFTNEDRRQGAVVL;TWPLSFVLYFT;VTFASSTLWIAAF 12 18.8 0.97951 0.035538 0 10.9341 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q689 A0A8I3Q689_CANLF Lysine demethylase 7A KDM7A Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] DEIIVKMHGSQLTQ;YHVLWGEKIFYL 2 3 0.99432 -0.11767 0 0 9.28575 0 11.075 0 0 0 0 0 0 0 0 0 0 A0A8I3Q698 A0A8I3Q698_CANLF "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase)" Canis lupus familiaris (Dog) (Canis familiaris) tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737] aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524] VIYEAPLGV 1 2.2 1.0047 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 7.59126 0 0 A0A8I3Q6A3 A0A8I3Q6A3_CANLF Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) IFT56 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary anterograde transport [GO:0035720]; intraciliary transport involved in cilium assembly [GO:0035735] ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; intraciliary transport particle B [GO:0030992] intraciliary transport particle B binding [GO:0120170] SEGEEVFLLIQSEKMKNDYIYLSW 1 5.7 0.99425 -0.28554 0 0 0 0 0 0 9.98982 8.69954 0 0 0 0 0 0 0 A0A8I3Q6A8 A0A8I3Q6A8_CANLF Replication factor C subunit 3 RFC3 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; response to organophosphorus [GO:0046683] Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663] ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; single-stranded DNA helicase activity [GO:0017116] TANAIVSEQT;TANAIVSEQTPQRL;THCIPPEI 3 6.2 1.003 -1.0312 0 0 0 0 0 0 10.5466 0 0 0 0 0 0 0 0 A0A8I3Q6B4 A0A8I3Q6B4_CANLF Pseudouridine synthase 7 like PUS7L Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] LDFFKYLDAKKE;VSPERLKN 2 3 0.88067 0.12998 10.3997 10.6046 10.6737 0 0 0 11.2336 11.3337 11.1547 10.7996 10.3851 10.6379 11.0276 11.1039 10.9746 A0A8I3Q6B9 A0A8I3Q6B9_CANLF Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) LOC106558049 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; transferase activity [GO:0016740] EAGIALNDHFVKLI;VNGFGHIGCLV 2 7.5 0.9924 -0.18091 0 0 9.93304 0 0 0 0 0 0 0 8.59865 0 0 0 0 A0A8I3Q6E3 A0A8I3Q6E3_CANLF Fetal and adult testis expressed 1 FATE1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562] endoplasmic reticulum [GO:0005783]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane [GO:0005741] identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625] GKSQEHLVIAE 1 6 0.99214 -0.0070217 0 0 0 10.4416 0 0 0 10.925 0 0 0 0 0 0 0 A0A8I3Q6F0 A0A8I3Q6F0_CANLF Beta-hexosaminidase (EC 3.2.1.52) HEXA Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] lysosome [GO:0005764] beta-N-acetylhexosaminidase activity [GO:0004563] ESYYIQTLLNIVSAYDK;LVDDSSFPYD 2 5.5 0.9887 -0.22392 0 0 0 8.87092 0 0 0 0 0 0 0 0 0 9.11676 0 A0A8I3Q6G6 A0A8I3Q6G6_CANLF Microtubule associated tyrosine carboxypeptidase 2 MATCAP2 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] DSKRSISHLSSGI;FSKDQVYLDGILQI 2 5.2 0.33099 0.60894 0 0 6.09297 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q6H4 A0A8I3Q6H4_CANLF Glycerophosphodiester phosphodiesterase domain containing 2 GDPD2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] phosphoric diester hydrolase activity [GO:0008081] SLLLLLALLLRL;TDPLLPQHTR;VTTNDCQLLQQMRYPV;WLFSLLWCAG 4 8.6 0.99599 -0.086162 0 7.69181 0 0 0 0 0 0 0 0 0 0 0 4.066 10.0147 A0A8I3Q6H5 A0A8I3Q6H5_CANLF Translocase of outer mitochondrial membrane 40 like TOMM40L Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150] mitochondrial outer membrane translocase complex [GO:0005742] protein transmembrane transporter activity [GO:0008320] LGGELVYHRRPGEE 1 5.1 0.87544 0.12725 0 0 0 9.72429 0 0 0 0 0 0 0 0 9.69033 9.99901 0 A0A8I3Q6H8 A0A8I3Q6H8_CANLF Chromosome 3 open reading frame 52 C3orf52 Canis lupus familiaris (Dog) (Canis familiaris) GVPSEDDSFM;MMNEELVRGVLLQSLHDEGV;VGLIVVIIVSLCLSGVTYIDE 3 23.5 1.0027 -0.79737 0 10.7448 0 0 0 0 0 0 11.7549 0 0 0 0 0 0 A0A8I3Q6H9 A0A8I3Q6H9_CANLF dolichol kinase (EC 2.7.1.108) DOLK Canis lupus familiaris (Dog) (Canis familiaris) dolichyl monophosphate biosynthetic process [GO:0043048] endoplasmic reticulum membrane [GO:0005789] dolichol kinase activity [GO:0004168] EVIEVLEVLLI;GIVVAATGMAVALF;GVGDTVASIFGS;VLPWLHRLIRKNPLLWLLQ 4 10.4 0.99404 -0.16304 0 0 0 0 0 4.6104 0 0 9.92388 6.59262 0 7.34323 8.14975 0 0 A0A8I3Q6J2 A0A8I3Q6J2_CANLF Uncharacterized protein LOC100682826 Canis lupus familiaris (Dog) (Canis familiaris) IKGIDSISFSHWYEKA;SPQSSCSF 2 6.9 1.0038 -1.0552 8.32854 8.99557 0 0 0 0 9.15851 9.56029 9.17443 0 0 0 0 0 0 A0A8I3Q6J7 A0A8I3Q6J7_CANLF Plastin 1 PLS1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; auditory receptor cell stereocilium organization [GO:0060088]; intestinal D-glucose absorption [GO:0001951]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896]; vestibular receptor cell stereocilium organization [GO:0060121] brush border [GO:0005903]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; terminal web [GO:1990357] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509] DINLLEGESKEE;EDLEELMKLSPEE;ERTFRNWMNSLGVNPY;FVNWINKALEDD;GKITFEEFVSLM 5 10.2 1.0035 -0.8763 0 0 0 0 0 0 12.3809 0 0 0 0 9.1696 0 9.61427 0 A0A8I3Q6L1 A0A8I3Q6L1_CANLF Protein kinase C-binding protein NELL2 (NEL-like protein 2) NELL2 Canis lupus familiaris (Dog) (Canis familiaris) commissural neuron axon guidance [GO:0071679] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] DENALCFNTVGGHNCVCKP;FTGPSCETD;GWYHCECRDGYHDNGMF;LKNVLSLKRPKKKKKV;NVLSLKRPKKKKKVK 5 7.4 0.99416 -0.073202 6.25113 0 0 0 0 0 7.91534 6.77939 4.04054 7.23582 0 0 0 3.62656 0 A0A8I3Q6L2 A0A8I3Q6L2_CANLF Leptin receptor LEPR Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] GYWSNWSSPAYTVIMDIKVPTR;RKYVVKHHTSRNGTWSEDVGNHTKF;TSWKNKDEMVPTTMVSLLL;YECIFQPIFLLSGYTMWIKI;YVLPEVLE 5 8.8 0.99883 -0.61086 0 0 0 0 0 0 10.7103 0 7.44526 0 0 0 8.28221 0 5.851 A0A8I3Q6L5 A0A8I3Q6L5_CANLF EH domain containing 4 EHD4 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; protein homooligomerization [GO:0051260] endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525] DCDCDGML;LADCDCDG;VYDELFYT 3 3.3 0.99817 -3.3132 4.7194 0 0 0 0 0 0 0 0 0 5.54062 0 7.76693 0 4.52688 A0A8I3Q6L9 A0A8I3Q6L9_CANLF aldehyde oxidase (EC 1.2.3.1) AOX4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; NAD binding [GO:0051287]; oxidoreductase activity [GO:0016491]" EKTKTYSALLKH;GGGCGACT;ITAEDVPGSNNHR;KTYSALLKHL;KYSCGGGGCGA;RVTLVHSRNPIA;VHILIFYCT;VIRKNPKG 8 5.1 1.0031 -2.3462 0 0 0 0 7.08821 0 10.0909 13.6151 0 6.56512 7.03375 7.5499 0 5.90222 0 A0A8I3Q6M6 A0A8I3Q6M6_CANLF Kyphoscoliosis peptidase KY Canis lupus familiaris (Dog) (Canis familiaris) ELKVQLPQAGKFALKIFVKKRLEP;ENANHNFYSYILKYK;LCCTNTKVNWPM;QIFAKGNSDIYSS;TFLYNEFYFLTHPALFIEDHFP 5 13.4 0.99254 -0.067798 0 0 10.5188 0 7.15714 0 0 0 0 0 9.30722 7.20447 7.03969 0 6.87787 A0A8I3Q6P9 A0A8I3Q6P9_CANLF PBX homeobox 1 PBX1 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IERMVSIIHRKFSSIQMQLKQST 1 7.6 0.97888 0.046273 0 0 0 0 0 0 5.0165 0 0 0 0 0 0 0 0 A0A8I3Q6Q5 A0A8I3Q6Q5_CANLF MIER family member 3 MIER3 Canis lupus familiaris (Dog) (Canis familiaris) FETGFYHSEL;VAFYYMWK 2 3.2 0.98544 -0.25858 0 9.9691 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q6R0 A0A8I3Q6R0_CANLF Peptidase inhibitor 15 PI15 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] peptidase inhibitor activity [GO:0030414] CQNMNVWGAVW 1 4.3 0.98349 -0.2525 0 0 0 0 0 0 14.0745 0 0 0 0 0 0 0 0 A0A8I3Q6R7 A0A8I3Q6R7_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT8 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] HLDEKIKLYN;LSVALKRNALR;VGYGRMKNT 3 5 1.0026 -1.129 0 8.14883 0 0 0 0 0 0 0 5.62021 0 0 0 0 13.9102 A0A8I3Q6S5 A0A8I3Q6S5_CANLF Chromosome 1 open reading frame 122 Canis lupus familiaris (Dog) (Canis familiaris) GEAAGVDRAKAG 1 10.9 0.94125 0.05044 0 0 0 0 7.87449 0 0 0 0 0 0 0 0 0 0 A0A8I3Q6T2 A0A8I3Q6T2_CANLF LRAT domain containing 1 LRATD1 Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; cell motility [GO:0048870] AELVVQNACGHLGL;GVAYFFSDEEEDLDERGQPD 2 11.3 0.98491 -0.25877 0 6.33958 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3Q6T3 A0A8I3Q6T3_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] DEHYTPIRTYQVCN;ETFNLYYME;GFVCQACRPGFYKASDGNMKCAKCP;HYTPIRTYQVCN;LETQSKNGP;SPNVRFLP;VGPVNKKGFYLAFQDVGACVALV 7 10.6 0.66135 0.31784 0 0 0 0 9.35271 0 10.5769 0 0 0 0 0 0 0 0 A0A8I3Q6W6 A0A8I3Q6W6_CANLF Cysteine rich secretory protein LCCL domain containing 1 CRISPLD1 Canis lupus familiaris (Dog) (Canis familiaris) face morphogenesis [GO:0060325] extracellular region [GO:0005576] EWLRVTTVLFMARAIP 1 3.2 0.96179 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.04849 A0A8I3Q6X0 A0A8I3Q6X0_CANLF Nicastrin NCSTN Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein processing [GO:0016485] plasma membrane [GO:0005886] EALQKAPDVATLP;RANNSWFQSILR;SINVSYPES;VSGDTGVIHVVE 4 7.4 0.98564 -0.44351 10.8379 0 8.57546 0 0 0 0 0 0 7.69126 0 7.90479 0 0 0 A0A8I3Q6Y9 A0A8I3Q6Y9_CANLF NIF3-like protein 1 NIF3L1 Canis lupus familiaris (Dog) (Canis familiaris) TVNTLFLTNDLT 1 4.2 0.98854 -0.26071 0 0 0 0 0 0 0 0 0 10.6758 0 0 0 0 0 A0A8I3Q6Z0 A0A8I3Q6Z0_CANLF Kinesin family member 4A KIF4A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DCGMDCSCDST;DSAGDDDDGADEEW;LQKEKEELVF;YNATVLAYGQ 4 3.8 0.9939 -0.17381 0 0 0 0 0 0 13.0326 4.77526 0 5.77418 0 0 5.20167 0 0 A0A8I3Q6Z7 A0A8I3Q6Z7_CANLF SIN3 transcription regulator family member B SIN3B Canis lupus familiaris (Dog) (Canis familiaris) autosome [GO:0030849]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; X chromosome [GO:0000805]; XY body [GO:0001741]; Y chromosome [GO:0000806] chromatin binding [GO:0003682]; transcription corepressor activity [GO:0003714] DLIVGFNAF;DSVEFNNAISYVN;GTLCRAKQVQPLVL;QKEQLSTKGRPFR;QYEDTLREMFTIHAY;VELEEYYPAFLDMVRSL 6 7.2 0.99125 -0.51311 8.96653 0 9.5108 0 0 0 0 0 6.35313 0 0 0 0 0 0 A0A8I3Q708 A0A8I3Q708_CANLF Rhomboid domain containing 3 RHBDD3 Canis lupus familiaris (Dog) (Canis familiaris) liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of protein catabolic process [GO:0045732]; regulation of acute inflammatory response [GO:0002673]; regulation of protein secretion [GO:0050708]; response to xenobiotic stimulus [GO:0009410] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ATGRVEGAVSLLVGGEV;LPTPGSLAEL;VGAVWAGPSFPPGTPL 3 11.1 0.99111 -0.13591 0 0 9.3168 0 8.39921 0 0 0 0 0 0 0 0 0 0 A0A8I3Q721 A0A8I3Q721_CANLF Vasculin (GC-rich promoter-binding protein 1) GPBP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] DSENDETCAPLTEDEMREFQVISE 1 5.1 0.97447 0.041303 0 0 0 0 5.62273 0 0 0 0 0 0 0 0 0 0 A0A8I3Q739 A0A8I3Q739_CANLF Actin beta like 2 ACTBL2 Canis lupus familiaris (Dog) (Canis familiaris) glutamatergic synapse [GO:0098978] DEHPILLTEAPLNPK;KDLYANIVL;LSTFQQMWISKQEYDEAGPPIV;LTEAPLNPK;TEAPLNPK;VAPDEHPILLTEAPLNPK;YASGRTTGIVMDSGDG 7 17.3 0.27559 0.68169 10.4147 8.66484 0 0 0 0 0 0 11.7024 0 0 0 0 0 0 A0A8I3Q779 A0A8I3Q779_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1M" PPM1M Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] ANTLHSCLRRQLE;FLRGSGSGP;LRRQLEAVVEGM;RRPGRARAPPQ;VLDTNIQL 5 7.1 1.0022 -1.8623 0 0 0 4.77831 0 0 9.27491 0 0 0 0 0 0 0 0 A0A8I3Q7C6 A0A8I3Q7C6_CANLF NAD(P)(+)--arginine ADP-ribosyltransferase (EC 2.4.2.31) (Mono(ADP-ribosyl)transferase) ART3 Canis lupus familiaris (Dog) (Canis familiaris) NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779] DPGMKNQESTVLPGMMSHE;LPMSFKDN;RRPCEDSYKNAV 3 9.7 1.0018 -1.3118 0 0 10.2494 0 0 7.62512 0 0 0 0 0 0 0 0 0 A0A8I3Q7H0 A0A8I3Q7H0_CANLF Plexin A3 PLXNA3 Canis lupus familiaris (Dog) (Canis familiaris) axon extension involved in axon guidance [GO:0048846]; branchiomotor neuron axon guidance [GO:0021785]; facial nerve structural organization [GO:0021612]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; hippocampus development [GO:0021766]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; olfactory nerve formation [GO:0021628]; positive regulation of cytoskeleton organization [GO:0051495]; pyramidal neuron development [GO:0021860]; trigeminal nerve structural organization [GO:0021637] plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] DRGSKMVSEIYL;DTVGGKGG;GATRTVRL;GDSEFYSYVEFPI;GPSKLFVGTAVDGKSE;IVCEMEESLV;LAPNLTEL;RQAAGQGTELWL;TCQVINDTAML;VAGVRCNSIPSEYV;VDGSQYAHLYETVP;VEVQVRGT;VGSPYPCHWCKYRHV;VLDVKPGSHVVLKG 14 8.4 0.99713 -3.6333 6.04763 10.6835 9.95345 0 0 0 10.5625 0 11.6494 8.76732 0 0 0 0 4.05866 A0A8I3Q7H7 A0A8I3Q7H7_CANLF SHOC2 leucine rich repeat scaffold protein SHOC2 Canis lupus familiaris (Dog) (Canis familiaris) LSMLSIRENKIKQLPAEIG;PLDFGTWTSMVELNLA;WTSMVELNLATNQ 3 7.1 0.85481 0.15858 0 0 0 0 6.9659 0 0 5.21175 0 0 0 0 0 0 4.67226 A0A8I3Q7I0 A0A8I3Q7I0_CANLF Sodium/hydrogen exchanger SLC9A8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular pH [GO:0051453] Golgi membrane [GO:0000139] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] FAVFGTAI 1 1.4 0.98932 -0.21659 0 14.7337 0 0 0 0 0 0 0 0 13.6159 0 0 0 0 A0A8I3Q7I5 A0A8I3Q7I5_CANLF ATP binding cassette subfamily A member 8 ABCA8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cholesterol efflux [GO:0010875]; sphingomyelin biosynthetic process [GO:0006686] basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EIIQVIFTNTFSYHLKFTL;IDDYKNKIQSQLRI;RVRFLKLKHER;VGSFLVFLIPFLHFI;VGSFLVFLIPFLHFIIFLFTLR;VYTLPLERT 6 4.7 1.0028 -0.89425 0 6.2745 5.33846 0 7.43654 3.25178 0 0 0 9.29094 6.65607 0 0 0 0 A0A8I3Q7I7 A0A8I3Q7I7_CANLF Kinase (EC 2.7.-.-) ITPKA Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of synaptic plasticity [GO:0048167] cytoskeleton [GO:0005856] "inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]" SEFFRRHEVIGSS 1 2.8 0.94357 0.059878 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.17812 A0A8I3Q7J8 A0A8I3Q7J8_CANLF TAP binding protein like TAPBPL Canis lupus familiaris (Dog) (Canis familiaris) GAILEPEQLLLAGDASLTLPSL;GVAPTENEESPQ 2 6 0.93601 0.098773 0 0 0 7.92979 0 0 0 0 8.29586 0 0 0 0 0 0 A0A8I3Q7L4 A0A8I3Q7L4_CANLF Taste 1 receptor member 1 TAS1R1 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of umami taste [GO:0050917] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527] EAGTFLNKSDLHSCQPCGKEEW;ESSPDFSLPG;HCCFECVPCEAG;LDCTEANSPGFMVAF;MYHLDRARTTV 5 8 1.0045 -0.81969 0 0 0 0 0 0 0 9.8194 0 0 0 7.81871 0 0 0 A0A8I3Q7M7 A0A8I3Q7M7_CANLF W2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] GLKELSEYKELQ;VMSTVEWN 2 7.8 0.94298 0.05044 0 0 0 0 0 0 0 0 8.77033 0 0 0 0 0 0 A0A8I3Q7P7 A0A8I3Q7P7_CANLF Partial AB-hydrolase lipase domain-containing protein LIPJ Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] NSRGTTWSRKHTYLN;PPARGSSRTPGAS;SQIISYWGYPDEVYDIVT 3 5.3 0.99403 -0.079825 0 0 0 0 0 0 0 0 9.2426 0 0 0 0 0 8.96754 A0A8I3Q7Q1 A0A8I3Q7Q1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VHISVCASMRVC 1 10.3 0.94811 0.05044 0 0 0 0 0 0 6.43321 0 0 0 0 0 0 0 9.04966 A0A8I3Q7Q6 A0A8I3Q7Q6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDEADYYCATDH;VGDYDMYWYQ 2 16.5 0.94794 0.05044 0 0 0 0 0 5.49083 0 0 0 0 0 0 0 0 0 A0A8I3Q7R1 A0A8I3Q7R1_CANLF Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) IMPDH2 IMPDH Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' XMP biosynthetic process [GO:0097294]; cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; lymphocyte proliferation [GO:0046651] cytosol [GO:0005829]; nucleus [GO:0005634] IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] DTVTEAGMAIA;EQGFITDPVVL;TVMMGSLLAATTEAPG;VLDSSQGNSIFQINM 4 10.3 0.99564 -0.086371 0 0 0 0 0 0 0 7.91205 0 0 0 0 0 0 0 A0A8I3Q7S7 A0A8I3Q7S7_CANLF SH3 domain-containing protein PRMT2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] protein-arginine N-methyltransferase activity [GO:0016274] LEECDPEDTWQDEEY;LFEFMIESILYARDVWL;QELVHPEEF;QNGFADIITVFQQK;VLSGDVVTGSVVLQ;VLSTGPFHPTTHWK 6 19.1 0.99192 -0.0024072 0 8.09998 0 0 10.0987 0 0 3.6427 12.1852 9.63959 9.33958 9.3779 0 9.90254 16.5002 A0A8I3Q7U0 A0A8I3Q7U0_CANLF 5-hydroxytryptamine receptor 3E HTR3E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888] LLGMEKEVWE;RWLHSLLLYWANPRT;TTQPPPMPRWLHSL 3 7.5 1.0037 -0.80358 0 0 0 0 0 0 8.30424 0 11.751 0 0 8.82365 0 0 0 A0A8I3Q7W4 A0A8I3Q7W4_CANLF Selenocysteine lyase (EC 4.4.1.16) SCLY Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] FPGTERLPNTCNF 1 3.7 0.94161 0.070839 0 0 0 0 0 0 0 0 6.32566 0 0 0 0 0 0 A0A8I3Q7Y6 A0A8I3Q7Y6_CANLF MAGE family member B18 MAGEB18 Canis lupus familiaris (Dog) (Canis familiaris) ITEDLVQLRYLEYRQAPDSF 1 5.8 0.98932 -0.19891 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.74901 A0A8I3Q7Z0 A0A8I3Q7Z0_CANLF Nucleoporin 54 NUP54 Canis lupus familiaris (Dog) (Canis familiaris) NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; protein localization to nuclear inner membrane [GO:0036228] nuclear pore central transport channel [GO:0044613] structural constituent of nuclear pore [GO:0017056] GAPSGTSGTAAAPA;GTGKGYFNN;IWEQAKVDNPDSEKL;KIAQYKRKLM;TSGTAAAPAAPAGGFGGF 5 12.4 1.0016 -0.74447 0 0 8.1573 0 0 0 0 0 9.52599 0 8.11072 0 0 0 0 A0A8I3Q7Z3 A0A8I3Q7Z3_CANLF Protoporphyrinogen oxidase (EC 1.3.3.4) PPOX Canis lupus familiaris (Dog) (Canis familiaris) heme A biosynthetic process [GO:0006784]; heme B biosynthetic process [GO:0006785]; heme O biosynthetic process [GO:0048034]; protoporphyrinogen IX biosynthetic process [GO:0006782] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758] oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729] AAPLAHALSA 1 2.1 0.99117 -0.27591 0 0 0 0 0 9.07922 0 0 0 0 0 0 0 0 0 A0A8I3Q7Z4 A0A8I3Q7Z4_CANLF EVA1 domain-containing protein EVA1B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EELERAQRLEERE;GTEAELHPHYYYYHYF;LEPDDDDDDDD;LEPDDDDDDDDEDTVT 4 8.4 0.84582 0.19368 0 0 0 0 8.0936 2.14499 9.33573 0 0 0 0 0 4.52995 0 9.75872 A0A8I3Q802 A0A8I3Q802_CANLF HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 HPS4 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] AAIEEVYHSSL;ATPQDRRFLQA;DLENIMPAKPHHPSR;EQFLDQLVGVFNFYN;GVEQCIGVHDSS;KGLIVSTQ;LDQLVGVFNFYN;RLRKLKFAI;STEPTSASWWNYF;WNLDRTKVEPLLLLKAALIL 10 17.3 1.0026 -1.3421 9.34501 6.34211 0 0 9.24899 0 0 0 14.5484 4.04745 0 0 0 0 15.6552 A0A8I3Q804 A0A8I3Q804_CANLF TruB pseudouridine synthase family member 1 TRUB1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400] mitochondrion [GO:0005739] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] VEAKPARP 1 2.4 1.0034 -1.1044 0 0 0 0 0 0 0 0 6.39123 0 0 0 0 0 0 A0A8I3Q807 A0A8I3Q807_CANLF Polycomb group ring finger 5 PCGF5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] PRC1 complex [GO:0035102] metal ion binding [GO:0046872] DPQIAICLDCLRNN;KFLSLKLKLPSSY;LVPGLREQEL 3 15.7 1.003 -0.85035 0 4.12681 0 0 0 0 8.12174 0 0 0 0 0 0 0 0 A0A8I3Q823 A0A8I3Q823_CANLF Vesicular inhibitory amino acid transporter (Solute carrier family 32 member 1) (Vesicular GABA transporter) SLC32A1 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid import [GO:0051939] cell surface [GO:0009986]; cell tip [GO:0051286]; cone cell pedicle [GO:0044316]; dendrite terminus [GO:0044292]; inhibitory synapse [GO:0060077]; membrane [GO:0016020]; presynaptic active zone [GO:0048786] gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; glycine:proton antiporter activity [GO:0140799] AATDEEAVGFAHCDDLDF 1 3.4 0.97271 0.048313 6.0674 0 0 0 0 6.2997 0 0 0 0 0 0 0 0 0 A0A8I3Q844 A0A8I3Q844_CANLF Serine protease 37 PRSS37 Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339]; germ cell migration [GO:0008354]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of protein processing [GO:0070613] acrosomal vesicle [GO:0001669] serine-type endopeptidase activity [GO:0004252] EDHAPYLAYLRS 1 5.1 0.94488 0.05044 0 0 0 0 8.73176 0 0 0 0 0 0 0 0 0 0 A0A8I3Q850 A0A8I3Q850_CANLF Chromosome 3 open reading frame 70 C34H3orf70 Canis lupus familiaris (Dog) (Canis familiaris) HYVESCDEDTEEGAELSSEEDY;LSSEEDYSPESSWEPDEC;VESCDEDTEEGA 3 13.4 0.99273 -0.1748 0 0 0 0 0 9.45648 2.43256 0 0 0 0 7.43887 0 0 0 A0A8I3Q881 A0A8I3Q881_CANLF Ras homolog family member Q RHOQ Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; small GTPase-mediated signal transduction [GO:0007264] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901] AADPPGGL;AAGGGGGG;GGGGGGGG;GGGGGGSG;VGKTCLLMSYAND 5 11 0.99668 -0.57835 0 0 0 8.11374 0 0 0 6.17375 0 0 0 0 0 9.83919 0 A0A8I3Q8B2 A0A8I3Q8B2_CANLF Sodium/potassium-transporting ATPase subunit beta-1-interacting protein (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein) NKAIN3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] LHIIVVILGL;PSAHGMMD;VISIFMEEEDTYSC 3 16.3 0.98418 -0.24712 10.2371 0 0 0 0 0 11.9839 0 0 12.0474 0 0 0 0 0 A0A8I3Q8C9 A0A8I3Q8C9_CANLF Zinc finger PHD-type domain-containing protein PHF13 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] APPPPAGT;DSCSGWDSD;ETRAELGVRSGSGSGSRSLPPP;LKKKKKRKR;RKKTDKLKKKKKRKRRDS;SNFLLDRKKTDKLKKKKKRKRRDSD;TDKLKKKKKRKR;VTCFCMKPF 8 11.1 1.0032 -2.3232 7.17901 0 5.63665 0 0 5.1756 0 10.9604 0 0 7.2484 0 0 7.3435 0 A0A8I3Q8E6 A0A8I3Q8E6_CANLF Family with sequence similarity 83 member D FAM83D Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cell population proliferation [GO:0008283]; epithelial to mesenchymal transition [GO:0001837]; metaphase chromosome alignment [GO:0051310]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; protein localization to mitotic spindle [GO:1902480]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein catabolic process [GO:0042176]; regulation of TOR signaling [GO:0032006] cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle pole [GO:0097431] kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] YFPEQSDLEPPPLELGW 1 2.9 0.98517 0.046227 0 0 0 0 6.66178 0 0 0 0 0 0 0 0 0 0 A0A8I3Q8F3 A0A8I3Q8F3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AASASCCGCCGDSSGCG;AASASCCGCCGDSSGCGCC;AASASCCGCCGDSSGCGCCSGC;AASASCCGCCGDSSGCGCCSGCG;AASASCCGCCGDSSGCGCCSGCGCF;ASASCCGCC;ASASCCGCCGD;ASASCCGCCGDS;ASASCCGCCGDSSGCGCC;ASASCCGCCGDSSGCGCCS;ASASCCGCCGDSSGCGCCSG;ASASCCGCCGDSSGCGCCSGCG;ASASCCGCCGDSSGCGCCSGCGC;ASASCCGCCGDSSGCGCCSGCGCF;ASCCGCCGDSSGCG;ASCCGCCGDSSGCGC;ASCCGCCGDSSGCGCCSGC;ASCCGCCGDSSGCGCCSGCG;ASCCGCCGDSSGCGCCSGCGCF;ASCCGCCGDSSGCGCCSGCGCFP;CCGCCGDSSGCG;CCGCCGDSSGCGCC;CCGCCGDSSGCGCCS;CCGCCGDSSGCGCCSG;CCGCCGDSSGCGCCSGCGCF;CCGCCGDSSGCGCCSGCGCFP;CCGDSSGCGCCSGCGCF;CGCCSGCGC;CGCCSGCGCF;DSSGCGCCS;FPRRRRRQ;GCCGDSSGCGCCSGCGCF;GCCSCCGG;GCCSGCGC;GDSSGCGCC;GDSSGCGCCSGCGC;PAASASCCGCCGDSSGCGCCS;PAASASCCGCCGDSSGCGCCSGC;PAASASCCGCCGDSSGCGCCSGCGC;PEPAASASCCGCCGDSSGCGC;PEPEPAASASCCGCCGDSSGCGCC;SASCCGCCGDSSGCGCC;SASCCGCCGDSSGCGCCSG;SASCCGCCGDSSGCGCCSGCG;SASCCGCCGDSSGCGCCSGCGC;SASCCGCCGDSSGCGCCSGCGCF;SASCCGCCGDSSGCGCCSGCGCFP;SCCGCCGDSSGCGCCS;SCCGCCGDSSGCGCCSG;SCCGCCGDSSGCGCCSGC;SCCGCCGDSSGCGCCSGCG;SCCGCCGDSSGCGCCSGCGC;SGCCSCCG;SGCGCCSG;SSGCGCCSGCGCFP 55 48.9 0.99711 -6.721 9.54264 8.57452 8.01491 8.80313 9.55317 7.95664 9.36606 10.4604 8.12655 7.32787 8.10229 8.47444 12.3297 9.71608 6.52924 A0A8I3Q8F7 A0A8I3Q8F7_CANLF Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) G6PD Canis lupus familiaris (Dog) (Canis familiaris) glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098] glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661] AQREREQKAPGGRAARAES;RIFTPLLHKIEREKPQ;YQGNAFHQSDTHIFIIM 3 8.6 0.98556 -0.43478 10.2826 0 0 0 0 7.98874 0 0 0 0 0 0 0 0 0 A0A8I3Q8G8 A0A8I3Q8G8_CANLF Zinc finger protein 280C ZNF280C Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DDNDNPSQSKIS;MKHHLELEKQNSESWE;NSKMAELFMECE;VTPKKPKTNESVSEI 4 7.2 0.94325 0.05044 0 0 5.49172 7.5932 8.15208 0 0 0 0 0 0 0 0 0 0 A0A8I3Q8H8 A0A8I3Q8H8_CANLF WD repeat domain phosphoinositide-interacting protein 4 (WD repeat-containing protein 45) WDR45 Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422]; nucleophagy [GO:0044804]; protein localization to phagophore assembly site [GO:0034497] cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site membrane [GO:0034045] "phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]" CFCCAMETGV;EISVLIWDD;LAVRMRHDKIV 3 11.7 1.0031 -1.117 0 14.2305 0 0 0 0 10.2146 0 5.65673 0 0 0 2.44763 0 0 A0A8I3Q8J0 A0A8I3Q8J0_CANLF Ig-like domain-containing protein LOC119868806 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] DTGTWGSETETLSHIC 1 11.5 0.98478 -0.25713 0 0 0 0 0 9.46283 0 0 0 0 0 0 0 0 0 A0A8I3Q8J8 A0A8I3Q8J8_CANLF Transcription factor 12 (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] DINEAFKELGRMCQL;HSVSPTDINTSLPPMSS;NSLMYYYN;SLNSNYGGS;TDINTSLPPMSSFHRGS;TENKEKDENLH 6 12.1 1.003 -2.2953 11.1907 0 6.68804 7.65992 0 7.12784 0 0 3.85758 0 0 0 0 11.8802 0 A0A8I3Q8L7 A0A8I3Q8L7_CANLF Junctional adhesion molecule A (Junctional adhesion molecule 1) F11R Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032]; cellular response to mechanical stimulus [GO:0071260]; establishment of endothelial intestinal barrier [GO:0090557]; intestinal absorption [GO:0050892]; leukocyte cell-cell adhesion [GO:0007159]; memory T cell extravasation [GO:0035683]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of Rho protein signal transduction [GO:0035025]; protein localization to bicellular tight junction [GO:1902396]; protein localization to plasma membrane [GO:0072659]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell shape [GO:0008360]; regulation of cytokine production [GO:0001817]; regulation of membrane permeability [GO:0090559] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integrin binding [GO:0005178]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803] LKKLFLKDFMYLF;SEPEVRVAENKPAKLS 2 7.3 0.99277 -0.19254 0 0 0 0 0 0 0 9.31479 9.60615 0 0 0 0 0 0 A0A8I3Q8M9 A0A8I3Q8M9_CANLF "Prolyl 4-hydroxylase, transmembrane" P4HTM Canis lupus familiaris (Dog) (Canis familiaris) regulation of erythrocyte differentiation [GO:0045646] endoplasmic reticulum [GO:0005783] calcium ion binding [GO:0005509]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] DDVDLRDTRRHCDKG;GVLSLQEFSDMDLRDFHKYM;HYHAHVDSGP;VLSLQEFSDMDLRDFHKYMRSHK 4 9.9 1.0025 -0.7614 8.49765 0 0 0 0 0 9.99181 0 0 9.37223 0 0 0 0 8.02564 A0A8I3Q8Q6 A0A8I3Q8Q6_CANLF Ryanodine receptor 3 RYR3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AWKEILNLLYKLLAALIR;CCRFLCYFCRISRQNQKAMFEH;EEEEDEDSSYMLEIE;EEEEEDEDSSYM;EGTREKVLQNDEFTR;GGEGWGGNGVGDDLYSYGF;GLGDIMNNKVFY;IEECLLAICNH;IISTVDYL;IRNTTALFSQF;LINDVTSIRPNIFLGVAEGSAQYKK;LSVSNGNIQ;LVPYALLDEPTKKSNRDS;NALTERRSGKLPEKKLIFPYLIF;NGNIQVDASFMQTLWNVHP;NILKIINN;PEEEEEEDEDSSYMLEIEG;PTTLKELISQTMI;QCLEPLQMMALH;SHKKYDPD;TEWVSHSYSL;VDVLELCEQEDLMYFHYHTLR;YHILCSLYSLGTGKNIYVER;YMLEIEGEEEDS 24 6.7 0.99811 -0.61146 0 0 0 0 0 0 0 9.19825 0 0 0 0 2.84022 0 0 A0A8I3Q8T5 A0A8I3Q8T5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CFSCSCCC;SCSCCCHH;TPGRSPRMLIYNT 3 9.5 1.0031 -2.1492 0 0 5.22516 0 0 0 4.80674 4.53026 0 0 0 8.18339 0 0 0 A0A8I3Q8V7 A0A8I3Q8V7_CANLF Chromosome 10 open reading frame 62 C10orf62 Canis lupus familiaris (Dog) (Canis familiaris) MLWIQRKKRRKASLESV 1 7.9 0.98159 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 7.29976 0 A0A8I3Q8X6 A0A8I3Q8X6_CANLF Phosphatidylinositol transfer protein beta isoform PITPNB Canis lupus familiaris (Dog) (Canis familiaris) "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transfer activity [GO:0008526] EDIRRMEDETQKELETLRNQGQVR;HGLDPNTWKTV;HIDIADRSQVEPAD 3 18 0.88 0.13937 0 0 7.52262 0 0 8.0965 9.30895 0 0 0 0 0 9.04655 8.07291 8.83156 A0A8I3Q8Z9 A0A8I3Q8Z9_CANLF U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) UTP11 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040] KGVTQQIRLKRIA;KQDYLRALRKKAL 2 10.3 0.91704 0.11912 0 0 0 0 5.41806 0 0 0 0 0 0 0 0 2.71728 0 A0A8I3Q914 A0A8I3Q914_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) DUSP10 Canis lupus familiaris (Dog) (Canis familiaris) dephosphorylation [GO:0016311]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelium regeneration [GO:1905042]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; negative regulation of stress-activated MAPK cascade [GO:0032873]; oligodendrocyte differentiation [GO:0048709]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of adaptive immune response [GO:0002819]; regulation of brown fat cell differentiation [GO:0090335]; response to lipopolysaccharide [GO:0032496]; stress-activated MAPK cascade [GO:0051403] cytosol [GO:0005829]; nucleoplasm [GO:0005654] JUN kinase binding [GO:0008432]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; mitogen-activated protein kinase p38 binding [GO:0048273]; protein tyrosine/threonine phosphatase activity [GO:0008330] ALNCGCSTASCCTVATYD;GVGSPVAG;SKEIIVYDENTNEPSR 3 8.7 0.98764 -0.46872 16.596 16.561 4.58424 0 0 0 17.0259 17.0084 16.9624 0 3.31979 3.96172 0 0 0 A0A8I3Q929 A0A8I3Q929_CANLF von Willebrand factor A domain-containing protein 9 INTS14 Canis lupus familiaris (Dog) (Canis familiaris) integrator complex [GO:0032039] DIADISSPPV;PRPEPFVVDEEIDPI;TVWIKPSG;VGTGITDDNEDEN;YQRKHLAAHGLT 5 12 1.0021 -1.8238 0 0 8.84869 0 3.75958 9.73278 12.5865 10.5831 0 0 0 0 0 0 0 A0A8I3Q952 A0A8I3Q952_CANLF Coagulation factor IX F9 Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; zymogen activation [GO:0031638] extracellular space [GO:0005615] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ENSTEVEKILDNVTQP;IVAGEHNTEKREH;STEVEKILDN 3 6.9 0.98951 -0.3169 0 0 0 9.38946 0 0 0 0 9.90709 0 0 0 0 0 0 A0A8I3Q986 A0A8I3Q986_CANLF Thiosulfate sulfurtransferase like domain containing 1 TSTD1 Canis lupus familiaris (Dog) (Canis familiaris) "sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]" thiosulfate-thiol sulfurtransferase activity [GO:0050337] EENLIFFCQMGKR;EPAAFQALYAA;PAAFQALYAAEKPKLQEE 3 40.5 0.86729 0.14351 0 0 0 9.04821 8.75976 0 0 0 0 0 0 0 0 0 0 A0A8I3Q989 A0A8I3Q989_CANLF C2 calcium dependent domain containing 2 C2CD2 Canis lupus familiaris (Dog) (Canis familiaris) DAGRASPL;KGGILRKGAKLFFRRRHQ;QEPQESELDSWDLDK;SSLSVSEPG;VGAGPGSPEDTGRQLYGARLS;VLSTKPVDVREI 6 12.2 1.0025 -1.1461 4.64829 0 8.59585 0 0 0 11.4175 9.07988 0 0 0 0 0 0 0 A0A8I3Q9B0 A0A8I3Q9B0_CANLF Lipocalin 2 LCN2 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742] extracellular space [GO:0005615] enterobactin binding [GO:1903981]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron ion sequestering activity [GO:0140315] ALVYFRKVY;KSQEYFKITLY 2 10.1 0.99282 -0.28722 0 0 16.2229 0 0 0 0 0 0 14.9383 0 0 0 0 0 A0A8I3Q9B2 A0A8I3Q9B2_CANLF Tetratricopeptide repeat and ankyrin repeat containing 1 TRANK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] CYKDAFRCFEQI;ECEFGQDETDEL;GEGGWQGEGP;IGFNFLSHLLDLFWSNP;LAVCSKDLSGLNNG;LWKKFHIYWEKA;PAFKYFMRRDFVQ;QQVELDTSILE;RASAQTECFQEETREPGA;SQFYLEAAAKY;VAEALQDLL;VLALAPGGLEVL;VQRNFIELSKSTKATSHYK;VVDLLQFYFPESFDRLPRDSG 14 5.3 1.0033 -1.623 9.61794 0 0 0 0 0 8.55424 12.1362 8.82836 0 8.39785 10.0204 9.50154 0 11.2766 A0A8I3Q9B3 A0A8I3Q9B3_CANLF YY1 associated factor 2 YAF2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] LAPGRRRNIV 1 8.5 0.98544 -0.25858 7.91648 0 0 0 18.1141 0 0 0 0 0 0 0 0 0 0 A0A8I3Q9C1 A0A8I3Q9C1_CANLF Uncharacterized protein TRIAP1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid translocation [GO:0045332] cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] phosphatidic acid transfer activity [GO:1990050] EACTDMKREYDQCFN 1 19.7 0.95326 0.053884 0 0 0 0 0 0 0 0 0 0 7.21247 0 6.78856 0 0 A0A8I3Q9E7 A0A8I3Q9E7_CANLF Unc-119 lipid binding chaperone B UNC119B Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; lipoprotein transport [GO:0042953] ciliary transition zone [GO:0035869] lipid binding [GO:0008289] EQELLALDTIRPEH;GGGVLNRLKARRQA;HVLRLSRVTE 3 14.7 0.98749 -0.47775 0 0 0 0 0 0 0 13.5354 0 10.3256 0 0 0 0 0 A0A8I3Q9I8 A0A8I3Q9I8_CANLF Elastin microfibril interfacer 3 EMILIN3 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012] identical protein binding [GO:0042802] AEVHAIQEQVSSQ;GVELHLHLHLLLLLLLL;GVELHLHLHLLLLLLLLLTLSL;LAWRCCPGLTGEGCPEHLTD;LHLHLLLLLLLLLTLSLTL;LLLLLLLL;LLLLLLLLL;PSGQLGPGP;YVDRRLQRLWGS 9 10 1.0027 -0.86161 5.22655 11.2442 0 0 0 0 0 7.83618 0 0 0 0 8.99107 7.79546 10.7215 A0A8I3Q9K1 A0A8I3Q9K1_CANLF Transmembrane protein 237 TMEM237 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AVWNIVFIY;GFLAGCAVWNIV;PGMDLSEELMFCS 3 6.9 1.0018 -1.3059 0 0 0 0 0 0 0 9.08553 0 0 11.512 9.66759 0 0 0 A0A8I3Q9N2 A0A8I3Q9N2_CANLF NCK interacting protein with SH3 domain NCKIPSD Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; positive regulation of neuron projection development [GO:0010976] COP9 signalosome [GO:0008180] Arp2/3 complex binding [GO:0071933] AAMRDGGKYSLE;ALNLHLPAP;GSSSSELG;TTDEKVVAEPAVP 4 5.8 1.0032 -2.4122 8.52595 0 0 9.47511 0 0 0 0 0 0 0 0 6.57331 3.96763 0 A0A8I3Q9R2 A0A8I3Q9R2_CANLF Olfactory receptor OR1AB3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IGVYFSPMSSHTAQKD;VTGLGNLLIIL 2 8.6 0.99161 -0.5425 0 0 0 0 0 0 0 0 0 12.5535 0 0 0 0 0 A0A8I3Q9R4 A0A8I3Q9R4_CANLF Fibroblast growth factor (FGF) FGF14 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634] growth factor activity [GO:0008083]; sodium channel regulator activity [GO:0017080] LVDIFSKVRIFGLKKRRLR 1 7.7 0.95482 0.04941 0 0 0 0 0 0 0 0 5.25501 0 0 0 0 0 0 A0A8I3Q9U5 A0A8I3Q9U5_CANLF Caspase-6 (EC 3.4.22.59) CASP6 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type endopeptidase activity [GO:0004197] AAQEAEVAGVGAAPGA;ITLPRKARLLVLL;SSGVAGGL 3 7.4 1.0029 -0.97818 0 0 0 6.15166 0 0 0 4.374 0 0 8.53224 0 0 13.3665 0 A0A8I3Q9X9 A0A8I3Q9X9_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] KKFWLIPIGS;LSWVPVLVIVL 2 6.4 0.97947 0.035491 0 0 0 0 0 4.2709 0 0 0 0 0 0 0 0 0 A0A8I3Q9Y0 A0A8I3Q9Y0_CANLF DNA topoisomerase II binding protein 1 TOPBP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EVGSKKYLVAANLKKPILL;EYKHLPESL;GPRASLSRSGC;PENKTALLKK 4 3.4 0.98549 -0.43625 0 8.05767 0 0 0 8.49446 0 0 0 0 7.05181 0 9.00991 0 0 A0A8I3Q9Y9 A0A8I3Q9Y9_CANLF RAB3 GTPase activating non-catalytic protein subunit 2 RAB3GAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] DTIIDHASIGIMTL;EELVLQLKCRTY;GRPAGVPGAMACSIVQ;GSVKTVNVPFHLAL;IPRHPGVTEQNEELSI;PGAMACSIVQFCYF;QDKEVLASQLLVLTGQRLAH;SWQPQTYQICLVDPVSGS;VLLRLDEKELLKLQ 9 9 0.988 -0.34639 0 0 0 0 0 8.22487 10.3861 10.3765 10.602 0 0 0 0 4.47638 0 A0A8I3QA04 A0A8I3QA04_CANLF Dynein axonemal heavy chain 1 DNAH1 Canis lupus familiaris (Dog) (Canis familiaris) inner dynein arm assembly [GO:0036159]; sperm axoneme assembly [GO:0007288] inner dynein arm [GO:0036156]; microtubule [GO:0005874]; sperm flagellum [GO:0036126] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] EAVNYYVLNPKSITMGQLYGEFDLL;EERPDLEE;EFLYNLSTEDFND;EGKQIAWVKWMD;EVFRARLRQFPSLVNCCTIDWFNEW;FIDDLNMPALETYGAQ;GAPTIAHFTDPLVEATIMVY;GLVRDEMGKPILN;LVAAGFVAYLGPFT;LVSEEDRGWFDKLLE;MDSSTPFTMMPDTNYCN;MFLDEYEDIP;NQINTAKLKLVLF;QKDLDEAL;SEDINRQLPVESKRY;VERFMFEGVEIPL;VGVLDYDKEKKLYLV;VSVPKYPFQ 18 6.1 0.99667 -4.5515 6.07534 0 0 6.76633 6.69766 0 12.9208 11.0509 9.67053 0 8.37256 10.4835 0 8.58207 0 A0A8I3QA27 A0A8I3QA27_CANLF VTT domain-containing protein TMEM41A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KVSLLQRKVEENRNSL;TVFKLLAIALVALVPGTLIK;VFKLLAIALVALVPGTL 3 14.3 0.99085 -0.26818 0 0 0 0 8.63343 0 0 10.7942 0 0 0 8.89379 0 0 0 A0A8I3QA39 AMOL2_CANLF Angiomotin-like protein 2 AMOTL2 Canis lupus familiaris (Dog) (Canis familiaris) hippo signaling [GO:0035329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein localization [GO:1903829]; Wnt signaling pathway [GO:0016055] recycling endosome [GO:0055037] ENARLQRDNERLQREL;GESHLAENTLYRLCP;HRLIQEQLRY;RNKMDSEMRRLQDFNRDLRERLES;SPQPSPSS 5 9.4 1.0033 -1.5714 0 0 9.20982 0 0 0 6.80323 0 0 6.21411 5.91998 0 0 7.02481 0 A0A8I3QA55 A0A8I3QA55_CANLF RNA helicase (EC 3.6.4.13) IFIH1 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; type I interferon-mediated signaling pathway [GO:0060337] mitochondrion [GO:0005739] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; ribonucleoprotein complex binding [GO:0043021]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270] DETHVAFPSI;DSDESGEDGD;DSGTMGSDSDEENVAE;GDGDGDGD;MRRYLKQKLKNNKLKKEYKPVIPL;NMTPVFKELYIVRENKAL;NVSLHMVGSPSLRSLQQ;PELADLPS;QEGDSDESGEDGDGDGDGDEAED 9 11.2 1.0044 -1.0882 0 4.18975 7.44807 0 0 0 9.08725 0 10.3647 7.55036 8.71366 3.93555 9.15598 0 4.03659 A0A8I3QA86 A0A8I3QA86_CANLF Malectin MLEC Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] carbohydrate binding [GO:0030246] AAVALLRLLLLL;ALLRLLLLLLLPALR;GAAVALLRLLLLLLLPALRG;LLLLLLLP;LRLLLLLLLPALRGPG;RLLLLLLL;SLIQAWRRKRRKKKKK;VALLRLLLLLLL 8 17.8 0.95744 0.049233 0 0 0 0 0 0 5.84034 0 0 0 0 0 0 0 0 A0A8I3QA95 A0A8I3QA95_CANLF Tyrosine-protein kinase (EC 2.7.10.2) BMX Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytosol [GO:0005829] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713] DLAARNCLVD;EENLEDYDWFAGNIS;GLEASQLLEMCYDVCE;SMSEDEFFQEAQTM;VGTHNLPEPAP 5 10.2 0.93613 0.069145 11.4578 11.1161 11.2993 0 4.92989 0 11.1814 11.2253 11.2728 10.3579 10.3684 11.4413 10.7323 10.8911 11.0329 A0A8I3QAA3 A0A8I3QAA3_CANLF Coiled-coil domain containing 158 CCDC158 Canis lupus familiaris (Dog) (Canis familiaris) ALDKASLQFAECQDIIQ;DKVIEILRQQIENMTQLVGQHG;GKPEEEGRAPSLGVSYVAVSNNS;LQELRSVINEEPAV;QEKRIQKVKDQEKM;QSQLEIIQEQARNQ;TEGSKSSDTLSREP 7 11.6 0.97378 0.046511 0 0 0 6.90893 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QAA7 A0A8I3QAA7_CANLF Uncharacterized protein EXOG Canis lupus familiaris (Dog) (Canis familiaris) endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] DDSFMSRYK;EAIGFQPQLNEFQVSLQD;LGGSGRSLGVFVAGAAVG 3 14.2 1.0027 -0.80102 0 0 0 0 0 8.91199 0 5.63541 0 0 0 9.59559 0 7.55842 0 A0A8I3QAG3 A0A8I3QAG3_CANLF PHD finger protein 7 PHF7 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] LSVHYFCLIL;RMGIHIPDRDAAWELE 2 6.8 0.98705 -0.40705 0 0 0 0 10.0987 0 0 0 0 10.8445 0 0 0 0 0 A0A8I3QAI1 A0A8I3QAI1_CANLF Trafficking kinesin protein 2 TRAK2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] ELRSRSGPSAHLYLSQSYGAFSGE;FFAEEWERKIQVLA;QLDMLQEKLKELEEE;STITFSSTMS 4 7.1 1.004 -0.8289 7.75995 0 0 0 0 8.91091 0 0 9.58222 0 0 0 0 0 0 A0A8I3QAJ9 A0A8I3QAJ9_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP2 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] endoplasmic reticulum [GO:0005783] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] PGGGGGDL 1 2.1 1.0041 -1.1044 0 0 0 0 0 0 0 9.39345 0 0 0 0 0 0 0 A0A8I3QAK3 A0A8I3QAK3_CANLF MAX dimerization protein MGA MGA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] MLL1 complex [GO:0071339] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EDQLKEKKRRKKLEYTIC;EEYGVRNENSSK;ESTFHKLKMKDLKDS;GKRGRPRKLKLSKAGRP;LENPEKKSNEFP;LKRHNKVDNLE;PASEPDVLK;PGKNLKAFV;PSLSPSFQQPGSCQSNPENC;PVVSSEPVQVCSPV;SEQQPLKP;SPDLRMVQ 12 5 0.99709 -3.9635 10.2896 9.91111 0 4.70565 8.81951 9.15525 0 0 10.2701 0 9.98613 2.08716 10.5881 0 9.07508 A0A8I3QAL4 A0A8I3QAL4_CANLF Starch binding domain 1 STBD1 Canis lupus familiaris (Dog) (Canis familiaris) glycophagy [GO:0061723]; intracellular transport [GO:0046907]; substrate localization to autophagosome [GO:0061753] endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; T-tubule [GO:0030315] cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; starch binding [GO:2001070] LVGGGLAG;LYSSNLVIDRAKEVSL 2 6.9 0.96507 0.049233 0 0 0 0 0 0 0 0 9.98356 0 0 0 0 0 0 A0A8I3QAP4 A0A8I3QAP4_CANLF Ras-related GTP-binding protein RRAGC Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of autophagy [GO:0010507]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657] FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654] enzyme-substrate adaptor activity [GO:0140767]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; protein heterodimerization activity [GO:0046982]; protein-membrane adaptor activity [GO:0043495] ALVCILREE;GVGAGAGG;PTLENLLNIFISNSGIEKA;VIDAQDDYMEA 4 11.8 1.0028 -1.1615 7.4545 0 0 9.10431 0 10.069 0 7.86913 0 0 3.8505 0 0 0 9.7363 A0A8I3QAQ7 A0A8I3QAQ7_CANLF Frizzled class receptor 7 FZD7 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; non-canonical Wnt signaling pathway [GO:0035567] endosome membrane [GO:0010008]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] ALPAGAGA;GGGGEQSL;GGGGGGGE;GGGGGGGG;LPAGGGGGG;LSGCYFMVAVAHVA;RKGGGGGG;RSLCERARQGCEA 8 7 0.99908 -3.2179 11.4011 0 10.9896 0 11.3175 0 4.00504 10.8009 0 0 11.2635 11.4751 0 11.821 0 A0A8I3QAR5 A0A8I3QAR5_CANLF Normal mucosa of esophagus specific 1 C30H15orf48 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex IV [GO:0005751] ETVDPSVP;GGGGGGGA;GGGGGGGG 3 7.5 1.004 -1.1044 0 0 0 0 6.92564 0 0 0 0 0 0 0 6.80645 0 0 A0A8I3QAS6 A0A8I3QAS6_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP1A4 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cellular response to steroid hormone stimulus [GO:0071383]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; L-ascorbic acid metabolic process [GO:0019852]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization [GO:0051899]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neuronal action potential propagation [GO:0019227]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; potassium ion import across plasma membrane [GO:1990573]; regulation of blood pressure [GO:0008217]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to potassium ion [GO:0035864]; sodium ion export across plasma membrane [GO:0036376]; visual learning [GO:0008542] cell projection [GO:0042995]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; potassium ion binding [GO:0030955]; protein-folding chaperone binding [GO:0051087]; sodium ion binding [GO:0031402]; steroid hormone binding [GO:1990239] EDSPQSHVLVMKGAPE;EEVVVGDLVEVKGGD;ETRNICFFSTNCVEG;FLGVSFFVLS;LEFTCQTAFF 5 6.3 0.98978 -0.52818 0 0 9.7262 0 0 0 0 0 0 0 0 9.83763 9.78419 10.7729 0 A0A8I3QAU9 A0A8I3QAU9_CANLF RNA helicase (EC 3.6.4.13) DHX37 Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] CLVPWAESELQ;EVQVSEAEMRLFYTTSKLGTGDR;IGLLSRIVSLRAKRHLPLKL;LSRIVSLRAKRHLPLKLL;LSRIVSLRAKRHLPLKLLI;VLPGKKKKK;WPLPAVQVDFPEGIDCYKHFARFL 7 8.5 1.003 -0.86082 8.90156 0 9.90775 0 0 8.94717 0 9.44549 7.60296 0 7.48478 0 0 7.1234 0 A0A8I3QAV8 A0A8I3QAV8_CANLF Vitamin K-dependent protein S PROS1 Canis lupus familiaris (Dog) (Canis familiaris) fibrinolysis [GO:0042730] extracellular space [GO:0005615] calcium ion binding [GO:0005509] FAGLPRKVENVLI;GDRCEYDINECKDPSN;IMPDICGA;KGNTSRRRRSS;SFRAGLFTAA;TAVTAGHSRHSGLQ;VDECSENLCAQLCVNY 7 11.2 0.99225 -0.18048 0 5.96751 0 0 0 0 0 10.8232 0 0 0 0 0 0 0 A0A8I3QAY2 A0A8I3QAY2_CANLF Tudor domain containing 1 TDRD1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DLEDVGKMTAEN;DPLGVEEKL;DYGNLETLPLS;NVGNSSPP;QADSSVSSNPNSISGE;YRALVKEILADG 6 6.2 1.003 -0.73687 0 0 0 0 0 11.1228 0 0 11.7437 0 7.58459 0 12.3469 0 10.9682 A0A8I3QAZ0 A0A8I3QAZ0_CANLF Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) SQOR Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] BLOC-1 complex [GO:0031083]; transport vesicle [GO:0030133] EDLTVEDKAVE;KTSKLKKRALKLQ;SKLKKRAL 3 14 1.0029 -1.3316 0 0 0 0 5.49892 0 0 0 0 9.58397 10.3952 0 0 0 0 A0A8I3QAZ3 A0A8I3QAZ3_CANLF "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1" PFKFB1 Canis lupus familiaris (Dog) (Canis familiaris) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex [GO:0043540]" "6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]" EHGYKGVCEEMTYEEIQE 1 6.6 0.9721 0.048313 0 0 0 0 0 6.42978 0 0 0 0 0 0 0 0 0 A0A8I3QAZ6 A0A8I3QAZ6_CANLF cholestenol Delta-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) EBP Canis lupus familiaris (Dog) (Canis familiaris) sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789] cholestenol delta-isomerase activity [GO:0047750] WGGGPPAL 1 3 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 9.32321 0 0 0 0 0 A0A8I3QB03 A0A8I3QB03_CANLF Family with sequence similarity 43 member A FAM43A Canis lupus familiaris (Dog) (Canis familiaris) AGPVPPGA;ALAAALHL;DGCTEGCTEGSIEGCA;EADEDQDEDEDEDEE;EADEDQDEDEDEDEEEGEDG;GGSAGPVP;QEEEADEDQDEDEDEDEEE;QEQRLQEEEADEDQDEDEDED;VPLVPLRKL 9 16 0.99733 -3.8695 0 11.0432 0 7.11873 3.6049 0 0 0 0 4.80178 0 0 10.8741 5.06815 0 A0A8I3QB07 A0A8I3QB07_CANLF Cyclin O CCNO Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; mitotic cell cycle [GO:0000278]; multi-ciliated epithelial cell differentiation [GO:1903251] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; nucleolus [GO:0005730] LVSPAARAGKRDN;SLARQPQVTAE 2 6.8 0.98771 -0.46097 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.02931 A0A8I3QB13 A0A8I3QB13_CANLF Borealin (Cell division cycle-associated protein 8) CDCA8 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic metaphase chromosome alignment [GO:0007080] "chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; intercellular bridge [GO:0045171]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]" GSRVAKTS;HYSTVTPA;PEALGNIKKLSSRLAQ;QTPLKSAKTRKIIK 4 16.5 1.0019 -1.2603 8.09998 0 0 0 0 0 0 0 12.1994 0 0 0 0 6.2331 0 A0A8I3QB27 A0A8I3QB27_CANLF MAGE domain-containing protein LOC119868268 Canis lupus familiaris (Dog) (Canis familiaris) RAQLLPRALRRG;VGVAAAAA;VPRAALQK 3 5.9 0.98787 -0.4609 0 0 0 0 0 3.95271 0 0 0 0 0 0 0 0 0 A0A8I3QB30 A0A8I3QB30_CANLF Zinc finger protein 277 ZNF277 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EDDRELLDHQEDDWSDWEEH;FPMDEQDKLLK;IEKLCVHMEDAH;QEDDWSDWEEHP;WDQPEYYFPTYEND 5 12 0.99637 -0.091737 0 0 0 0 5.35917 0 0 9.40825 7.0765 0 0 0 0 0 4.43856 A0A8I3QB57 A0A8I3QB57_CANLF TP53 induced glycolysis regulatory phosphatase TIGAR Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EQCSQGAPSNSL;PGLVASVLVV 2 8.2 1.0027 -0.89503 0 0 0 0 0 0 0 0 0 0 0 0 8.56468 0 0 A0A8I3QB59 A0A8I3QB59_CANLF Leucine rich repeat containing 15 LRRC15 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] apical plasma membrane [GO:0016324]; collagen-containing extracellular matrix [GO:0062023] collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; protein sequestering activity [GO:0140311] ACSLVACICCCCCK;GLMTIQLQ;GVFDHLVGLTKLNLGKN;LAYYGCPSECTCS;PMHNLRELWLYDN;YLLLLVGCQAWSA;YPETPQYPDTP 7 15.3 0.99296 -0.18794 0 0 11.1506 0 0 0 0 8.56917 0 6.81301 0 6.49621 0 5.79849 0 A0A8I3QB60 A0A8I3QB60_CANLF Lysine-specific demethylase (EC 1.14.11.65) HR Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] AWHRAQKDFLSGLDGEGLW;EGLRWKEAMLTHPLAL;GLSKGLAKHLLSGL;GPLPCPSL;GTPGCCYLDAGLRRRLREEWGVN;LVSSLPPER;PSHHTKLK;QLWAAYGVSPHRG;RCHRGLFNT;VGCCSSHPRARDGG 10 11.2 0.99908 -3.2242 6.42734 10.3205 10.3818 0 0 0 0 9.66292 8.95318 0 10.2503 0 0 9.12228 10.0532 A0A8I3QB66 A0A8I3QB66_CANLF Tektin-2 ADPRS Canis lupus familiaris (Dog) (Canis familiaris) cilium movement involved in cell motility [GO:0060294] cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815] "hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]" GDTDTIATMAGAIAGA;PESWQQSCEGYEET;PWGPRTPCPDGH 3 6 0.98972 -0.27359 0 0 0 0 7.71431 8.6004 0 0 0 0 0 0 0 0 0 A0A8I3QB72 A0A8I3QB72_CANLF Tubulin alpha chain TUBA8 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017]; spermatid development [GO:0007286] acrosomal vesicle [GO:0001669]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] CFEPNSQM;DIERPTYTNL;DYGDDCRMWNE;EFAIYPAP;THTTLEHSDC;TVVPGGDLAKVQ 6 11.9 1.0036 -1.0689 0 0 0 0 0 0 0 0 0 0 7.97407 0 0 0 0 A0A8I3QBA4 A0A8I3QBA4_CANLF Smad nuclear interacting protein 1 SNIP1 Canis lupus familiaris (Dog) (Canis familiaris) "miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]" cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U2-type precatalytic spliceosome [GO:0071005] mRNA binding [GO:0003729]; transcription regulator inhibitor activity [GO:0140416] DVVAAAMV;GVVIKYSEPP 2 4.5 1.0036 -0.8763 6.75622 0 0 0 0 0 7.87154 0 0 0 0 0 0 0 0 A0A8I3QBC2 A0A8I3QBC2_CANLF Argonaute RISC component 1 AGO1 Canis lupus familiaris (Dog) (Canis familiaris) miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of angiogenesis [GO:0016525]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pre-miRNA processing [GO:0031054]; RISC complex assembly [GO:0070922]; RNA secondary structure unwinding [GO:0010501] cytosol [GO:0005829]; P-body [GO:0000932]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578] core promoter sequence-specific DNA binding [GO:0001046]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727] GADVTHPPAG;GNGGCGGS;LDVAMRHLASMR;NGGCGGSG;VGSMDAHPSRYCATVRV 5 4.6 1.003 -2.4807 5.75721 5.37083 0 0 0 0 0 6.85674 0 0 0 0 0 0 0 A0A8I3QBF9 A0A8I3QBF9_CANLF Angiotensin-converting enzyme (EC 3.4.-.-) ACE2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241] DYWRGDYEEEWENGYNYSRNQ;FEDSETEINFL;PFGQKPNIDVT;RCCCSDSYPEVFCPSL 4 8.4 0.95623 0.049233 0 0 0 0 0 0 0 0 6.9384 0 0 0 0 0 0 A0A8I3QBG1 A0A8I3QBG1_CANLF Centrosomal protein of 63 kDa CEP63 Canis lupus familiaris (Dog) (Canis familiaris) centriolar satellite [GO:0034451] EKAVEHKEILDQMES;QIDIMVAHKKSEW 2 5.1 0.99454 -0.12491 0 0 0 0 0 0 0 0 0 0 0 0 0 14.9484 0 A0A8I3QBG5 A0A8I3QBG5_CANLF Splicing factor 3b subunit 1 SF3B1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase III [GO:0045945]; spliceosomal complex assembly [GO:0000245] B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; U11/U12 snRNP [GO:0034693]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; splicing factor binding [GO:1990935] AATELEDDDDDY;AGELKVVN;GWAETPRTDRGG;LMNEYRVPEL;LVEIIEHG;PAGAATPGRGDTPG;PKTERDTP;QTPGATPKKLSSWD;RVKPYLPQ;VLKPLWKGIRQHRGKGL 10 8.5 0.99981 -2.8461 7.5004 0 0 0 12.743 12.9197 0 13.5609 12.4826 7.24726 8.79399 0 0 7.21907 10.1224 A0A8I3QBH1 A0A8I3QBH1_CANLF Angiotensin-converting enzyme (EC 3.4.-.-) ACE2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] apical plasma membrane [GO:0016324]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241] DYWRGDYEEEWENGYNYSRNQ;FEDSETEINFL;KFWKPRNFEESEIE;PFGQKPNIDVT 4 8.6 0.98759 -0.46423 8.84847 0 0 0 0 0 6.76739 0 0 0 0 0 0 0 0 A0A8I3QBH7 A0A8I3QBH7_CANLF RNA binding motif protein X-linked 2 RBMX2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; U2-type precatalytic spliceosome [GO:0071005] RNA binding [GO:0003723] KEKKRRKKDKE;PYELTEGDIICVFSQYGEIVNINLV;RREEREEKNRERERQRERERDRDRD 3 17.9 0.98775 -0.46401 0 9.92736 0 0 0 0 0 16.3907 0 0 0 0 0 0 3.0679 A0A8I3QBJ4 A0A8I3QBJ4_CANLF Cyclin dependent kinase 15 CDK15 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] DIIHTKETLTFV;HHQHVLHRDLKPQNLLISHLGE;LVHDYFSALPSQLHQLPDEES 3 12.6 1.0025 -0.76161 9.57537 0 0 0 0 0 0 0 11.0926 10.4038 0 0 0 0 0 A0A8I3QBK2 A0A8I3QBK2_CANLF Kinesin family member 21A KIF21A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoskeleton [GO:0005856]; cytosol [GO:0005829] ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ACVSPSDRDFM;DESDSSLSEV;DKAFTFDYVFDIDSQQ;DLFDTTRDIDAKN;EVSDHEEEEEEEEEEEDDI;GRLKQTEIT;GVVPGHPVLL;IDLAKKDLEKLKRKEKKKKK;KLKRKEKKKKKRLQ;KLKRKEKKKKKRLQKLEE;LEKLKRKEKKKKKR;QEVSDHEEEEEEEE;RKLSSSDTPVQDMGSTAAAVEA;SPLQCIHIAEGHT 14 9 0.98973 -0.26397 0 0 0 7.66498 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QBM1 A0A8I3QBM1_CANLF Coiled-coil domain containing 88B RPS6KA4 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent intracellular transport [GO:0030705]; defense response to protozoan [GO:0042832]; positive regulation of cytokine production [GO:0001819]; positive regulation of T cell proliferation [GO:0042102] centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLTLQESGPTVATQKCPEN;EEKERTFSFCGTIEYM;ELEQAALERQEF;EQAALERQEFLRE;HIVLTDFGLSKEFL;LSEELAQARKT;MRRAQSSLCLRDETLAG;QEFQHQRYQ;QRYQGLEQRLETE;QTWQGPISGEISS;VRGRELGARLEHLQSELEQAA 11 8 1.0024 -0.90059 10.2755 11.823 0 7.82763 0 0 12.2214 0 0 0 0 0 11.1563 9.54686 0 A0A8I3QBM7 A0A8I3QBM7_CANLF Uncharacterized protein ZRSR2 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245] U12-type spliceosomal complex [GO:0005689]; U2AF complex [GO:0089701] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628] EQQRREREEEEQKLQEKRE;KAKRKKRRQEL 2 6.5 0.98314 -0.25597 0 0 0 0 0 9.76906 0 0 0 0 0 0 0 0 0 A0A8I3QBS0 A0A8I3QBS0_CANLF Teneurin transmembrane protein 1 TENM1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] ATAITVTLALLLAYVIAVHLF;AVNLIYTFAWN;CDMEAQAG;DDCSTNCNGNGECISGHCHCF;DPEGHLTNATFP;EQCIDPTCFGHGTCIMGVCICVP;GDGLTDCVDPDCCQQ;GDQCLPFDQSHCGD;GVCICVPG;GVNVSFLHHSDYGFTISR;ISLPGEHNA;IVLQISEN;KQLNLLPKPF;LHHSDYGF;LSDSANNIHF;PSPAAPAPPTSTQDSVHLH;SSGEEYYV;VGKIQDVAKYTTDIGSWLELF;VHIRRDAGGMPL 19 8.8 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 5.22311 0 0 0 A0A8I3QBX3 A0A8I3QBX3_CANLF Exocyst complex component 3 EXOC3 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] exocyst [GO:0000145] DWIKETEPEADQD;KESIVSLKRKY;MDGILDAIAKAGC;WIKETEPEADQDGYYQTT 4 5.8 0.99385 -0.078117 7.07393 12.871 0 0 8.77854 0 0 0 10.0196 0 0 0 0 0 0 A0A8I3QBX9 A0A8I3QBX9_CANLF Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 PYROXD2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] oxidoreductase activity [GO:0016491] GQPLPHHQCSIHLNCEDTLLLHQAF;VERISRLDTKSP 2 6.8 0.9408 0.085978 0 6.55683 0 0 0 0 0 9.03738 0 0 0 0 0 0 0 A0A8I3QBZ4 A0A8I3QBZ4_CANLF Taxilin gamma TXLNG Canis lupus familiaris (Dog) (Canis familiaris) syntaxin binding [GO:0019905] EEKLAALCKK;LNEIQAQLEQHDLHNAKLRQE;RDKEYKAFQIKLDRLEKLCR;TKKIKKLEKETIIWR 4 13.3 0.99216 -0.14171 0 6.43331 0 0 0 9.17774 0 4.72503 6.33677 0 0 0 0 0 0 A0A8I3QC03 A0A8I3QC03_CANLF Cytosolic purine 5'-nucleotidase (EC 2.7.1.77) (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic nucleoside phosphotransferase 5'N) NT5C2 Canis lupus familiaris (Dog) (Canis familiaris) allantoin metabolic process [GO:0000255]; dGMP metabolic process [GO:0046054]; GMP metabolic process [GO:0046037]; IMP catabolic process [GO:0006204]; negative regulation of defense response to virus by host [GO:0050689]; protein K48-linked ubiquitination [GO:0070936] cytosol [GO:0005829] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; metal ion binding [GO:0046872]; nucleoside phosphotransferase activity [GO:0050146]; ubiquitin protein ligase activity [GO:0061630] CHDEDDDEEEEEEEE;GSQVAAQKRPETREQYPNKFI 2 6.3 0.92017 0.11505 0 0 0 0 5.60285 0 0 0 0 0 0 0 0 7.30989 0 A0A8I3QC24 A0A8I3QC24_CANLF Dystrobrevin DTNB Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] DSITNTMSSL;EPRTKVEADHNSHLCVLD;PEKAQQNPTL 3 6.7 0.97176 0.048313 0 0 0 0 0 0 0 0 0 6.43558 0 0 0 0 0 A0A8I3QC63 A0A8I3QC63_CANLF Uncharacterized protein SERBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA 3'-UTR binding [GO:0003730] KSSASAPDVDDPE;PERRPPRERRF;TDKSSASAPDVDDPE 3 6.4 0.99186 -0.28746 0 0 0 8.86904 0 0 0 5.66925 11.0629 0 0 0 0 0 0 A0A8I3QC91 A0A8I3QC91_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LHHNCISFPIWIPLQ 1 14.7 0.95223 0.053902 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.3993 A0A8I3QC92 A0A8I3QC92_CANLF Uncharacterized protein LOC611145 Canis lupus familiaris (Dog) (Canis familiaris) AAQEEACAED;LSPLRYFDL 2 7.8 1.0009 -0.92602 0 0 0 0 6.3579 0 0 0 0 0 0 0 0 0 0 A0A8I3QCH1 A0A8I3QCH1_CANLF Src homology 2 domain containing F SHF Canis lupus familiaris (Dog) (Canis familiaris) ENLLRLCKEASYLVRNSETSKNDF;GGGGGGGG;GGGGGGGGK;SLPDGDRDIS 4 9.5 0.99073 -0.51518 0 0 10.0432 0 0 0 0 10.2401 0 0 0 0 0 0 0 A0A8I3QCI6 A0A8I3QCI6_CANLF Uncharacterized protein RAB33A Canis lupus familiaris (Dog) (Canis familiaris) Rab protein signal transduction [GO:0032482] GTP binding [GO:0005525]; GTPase activity [GO:0003924] CDLREQIQVPSN;CGGTFPDKTEATIGV 2 11.4 0.98812 -0.49601 0 0 0 0 0 0 0 0 0 0 0 12.438 0 0 0 A0A8I3QCJ0 A0A8I3QCJ0_CANLF Fibronectin type-III domain-containing protein IFNGR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGGGGGG;LCLPGHPRKG;LRNVTVGPPENVWVTPGEG;PPENVWVTPGEG 4 6.9 0.99985 -0.61146 0 0 0 0 0 0 0 0 0 9.91117 0 0 0 0 0 A0A8I3QCJ7 A0A8I3QCJ7_CANLF Integrin beta ITGB5 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] cell surface [GO:0009986]; integrin alphav-beta5 complex [GO:0034684] DALHLLVFTTDD;EANEYTVSNQMD;GECSCNQCSCFESE;GVLCSGHGECHCGECKCHAGY;LCSGRGECSCNQCSC;LPSGKSNLTVLKEPEC 6 10 1.0017 -0.69282 0 0 0 0 0 0 0 0 0 13.8606 0 0 8.4463 0 4.55373 A0A8I3QCK4 A0A8I3QCK4_CANLF Fibronectin type-III domain-containing protein FANK1 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGGGGGSAL;PGTGTGIS;SGGSRVRGGRE 4 4.6 1.0022 -1.3609 0 0 0 0 0 0 10.7457 0 0 0 9.55382 0 0 0 0 A0A8I3QCL1 A0A8I3QCL1_CANLF Empty spiracles homeobox 2 EMX2 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; cell proliferation in forebrain [GO:0021846]; cerebral cortex regionalization [GO:0021796]; dentate gyrus development [GO:0021542]; forebrain cell migration [GO:0021885]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; response to xenobiotic stimulus [GO:0009410]; ureter morphogenesis [GO:0072197] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QRDPSTFYPWLIHRYRYLGHRFQGN;RKPKRIRTAFSPSQLLRLE 2 17.4 0.97874 0.035538 11.2654 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QCN1 A0A8I3QCN1_CANLF Aquaporin 12 AQP12 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] channel activity [GO:0015267] ACSPRTWCRHGAGCP;CSSALRTSVPHGT;PEEQVPNPEKEAGPGAGSHP;PVYRVPAVA;VTVMAYAAGP 5 18.3 0.93753 0.059573 0 0 0 0 0 0 0 0 0 0 0 9.62662 0 0 0 A0A8I3QCQ3 A0A8I3QCQ3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP26 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] DAQWYMQNLRRPTNLGPQQARVN;DGKSLLQMLSEKIYLTF;EKKKLRLKLLKKNQK;KKKLRLKLL;KKKLRLKLLKK;KKKLRLKLLKKNQKL;KKKSQTNPLRYV;KKLRLKLLKKNQKLE;QQARVNSQGASCSTKNP;STVAEIFSGNIQND;VHLKRYIFNEF;YVSHDEKKKLRLKLLKKNQKL 12 11.7 0.98792 -0.37521 11.4547 11.2084 0 0 5.86644 0 5.56325 0 8.35447 0 0 0 7.17981 9.54286 0 A0A8I3QCQ6 A0A8I3QCQ6_CANLF Zinc finger protein 485 ZNF485 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" IHTGEKPYECNV;QGAEPWMEVQQIPSDNYSVQE 2 7.4 0.96591 0.048523 0 0 0 0 7.1372 0 0 0 0 0 0 0 0 0 0 A0A8I3QD12 A0A8I3QD12_CANLF COP9 signalosome complex subunit 9 LOC119863900 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein neddylation [GO:2000435] COP9 signalosome [GO:0008180] ADEMFPEGPGPYVDLD 1 28.1 0.96081 0.049233 0 0 0 0 0 0 0 8.1005 0 0 0 0 0 0 0 A0A8I3QD37 A0A8I3QD37_CANLF ASXL transcriptional regulator 2 ASXL2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; peroxisome proliferator activated receptor binding [GO:0042975] EGSERQPHPA;GCGAFCHDDC;GVPSAAHTNAPPP;IPAGKVIS;ISSNQPLSLK;KSRWKRKVS;LSSASNTH;QEEAPVSWEKRPRVTENRQHQQP;TSVGGTIPGPGPGGGQGPG;VGGTIPGPGPGGGQGPG 10 7.6 0.99713 -3.6166 6.9528 0 10.1153 0 0 11.3947 0 0 13.2353 6.92695 0 0 11.3318 0 0 A0A8I3QD39 A0A8I3QD39_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PAK2 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cellular response to organic cyclic compound [GO:0071407]; dendritic spine development [GO:0060996]; negative regulation of apoptotic process [GO:0043066]; negative regulation of stress fiber assembly [GO:0051497]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein localization to cell-cell junction [GO:0150105] cell-cell junction [GO:0005911]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activator activity [GO:0030296]; small GTPase binding [GO:0031267] FLNRCLEMDV;HTKSIYTRSVIDPIPAPVGDSNV;KKKEKERPEISPPSDFEH;VDIWSLGIMAIEMIEGEPPYLNENP;VGNQGPCCRSRALPGMR;VIDPIPAPVGDSNVDSG;VIVGGVVH;VLAVIVGG 8 14.9 1.0027 -2.5753 0 9.59835 10.2736 10.9921 0 11.1986 6.71864 0 8.78061 0 8.81829 8.95396 0 10.0149 10.1935 A0A8I3QD72 A0A8I3QD72_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) (Phosphatidylinositol-3-phosphate phosphatase) MTMR3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] cytoplasm [GO:0005737]; membrane [GO:0016020] metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721] APYPAPGT;CECPEYYPN;ETENKALEQ;GENSDDLNERCPV;LCTQMPDPGNW;PDPGNWLSALESTKW;PGTSPDDP;RNCGNVFCSSCCNQ;SLVNTASQSAASEIPV 9 8 0.99951 -2.8926 0 6.69335 9.26868 0 0 9.25927 8.82034 10.6389 0 0 0 0 0 0 0 A0A8I3QD98 A0A8I3QD98_CANLF Cadherin EGF LAG seven-pass G-type receptor 3 CELSR3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] ALAPRGAGAGAAGPWFSSE;ASASTLFRPI;GDFCETEL;ILQLRATDGDAP;LAVFTHVVMAV;LLVRLPRPGPALKTLR;NEKHDFLALE;PTCGPCNCD;RMRSRALFRRRFL;RPHTVVLRVTAT;RWHDLRLELQEEPGGRR;TGHTEHYF;VGGTVLNVS 13 5.7 0.9565 0.049233 5.32855 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QDC3 A0A8I3QDC3_CANLF Poly(rC) binding protein 4 PCBP4 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of mRNA splicing, via spliceosome [GO:0048025]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] KAERQKFSPY;VTITGSPV 2 5 0.94121 0.075664 12.0909 0 0 0 0 0 0 11.7975 10.8215 0 0 0 0 11.8956 0 A0A8I3QDI3 A0A8I3QDI3_CANLF Triacylglycerol lipase (EC 3.1.1.3) (Pancreatic lipase) PNLIPRP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular space [GO:0005615] metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806] IDKGEESWLANMCKKM;TDCAPIIPFLGFGMSQK;TDRKTRFIIHGFIDKGEESW;VIHTDCAPI;WAPKDVNTRLLLYTN 5 13.5 0.99389 -0.16316 0 0 13.4188 6.59947 8.90289 0 6.40931 0 0 0 0 0 0 8.89763 0 A0A8I3QDK9 A0A8I3QDK9_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC9 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation by host of viral process [GO:0044794]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; protein targeting to membrane [GO:0006612] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; palmitoyltransferase complex [GO:0002178] Ras palmitoyltransferase activity [GO:0043849] LAVQLSPAIP;LKETPGTVLEVLICF 2 6.9 0.98957 -0.53051 0 0 0 0 0 0 10.3911 0 0 0 0 0 0 0 10.0876 A0A8I3QDM4 A0A8I3QDM4_CANLF Small ribosomal subunit protein mS33 MRPS33 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] RDEHQDFKDEQLRLKKLRGKGKPRK 1 23.6 0.97465 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 4.84001 0 0 A0A8I3QDV1 A0A8I3QDV1_CANLF Ryanodine receptor 3 RYR3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AWKEILNLLYKLLAALIR;CCRFLCYFCRISRQNQKAMFEH;CQSGEDEEEEEDK;EEEEDEDSSYMLEIE;EEEEEDEDSSYM;GAPGAHAC;GGEGWGGNGVGDDLYSYGF;GLGDIMNNKVFY;IEECLLAICNH;IISTVDYL;IRNTTALFSQF;ISLAKARY;LINDVTSIRPNIFLGVAEGSAQYKK;LSVSNGNIQ;LVPYALLDEPTKKSNRDS;NGNIQVDASFMQTLWNVHP;NILKIINN;PEEEEEEDEDSSYMLEIEG;PLIRPFKT;PTTLKELISQTMI;QCLEPLQMMALH;SEIIGKDEP;SHKKYDPD;SKEIKEKLDSSHKRDIEG;VDVLELCEQEDLMYFHYHTLR;YHILCSLYSLGTGKNIYVER;YMLEIEGEEEDS 27 7 1.0025 -1.3585 0 0 0 0 9.73385 0 0 0 0 0 7.65671 0 0 0 0 A0A8I3QE22 A0A8I3QE22_CANLF Solute carrier family 45 member 1 SLC45A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glucose:proton symporter activity [GO:0005356] ADNPSHAYMMDVC;FWRSQVSGYSGSVTRHISH;GVTMGCWGMCIYA;LEPQEHPPAPPTMIPPASSTPP;MKSPSLPLPPSPPALCEE;YEIPPSDATEEEH 6 12.2 1.003 -0.85656 10.7398 0 8.91555 0 0 0 0 0 10.8869 0 0 0 0 0 9.32807 A0A8I3QE80 A0A8I3QE80_CANLF Protein FAM110B FAM110B Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytosol [GO:0005829]; mitochondrion [GO:0005739] CEQSQDSNSDLRNDDSAND;ISSDCEQSQDSNSDL;KRALGSPT;MISSDCEQSQDSNSDL 4 8.5 0.98678 -0.35879 8.65978 0 0 0 0 0 0 9.03108 0 7.42962 0 0 0 0 0 A0A8I3QE86 A0A8I3QE86_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPEG;LVESGGDLVK;SYWISWVCQFP;WISWVCQFPEKGLQ 10 18.6 0.9944 -0.12733 0 0 0 0 0 0 0 0 0 0 8.92113 0 0 0 0 A0A8I3QF47 A0A8I3QF47_CANLF DGCR8 microprocessor complex subunit DGCR8 Canis lupus familiaris (Dog) (Canis familiaris) primary miRNA processing [GO:0031053] microprocessor complex [GO:0070877] heme binding [GO:0020037]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] LAPSGEVSPV;LPDGWIMTFHNS;VRPVYNFFECARATLEILIPD 3 5.8 0.98891 -0.5245 0 0 0 0 0 0 0 9.39806 0 0 0 0 0 0 9.83294 A0A8I3QFD0 A0A8I3QFD0_CANLF Importin subunit alpha KPNA4 Canis lupus familiaris (Dog) (Canis familiaris) NLS-bearing protein import into nucleus [GO:0006607] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] WALSYLTDAGNE 1 2.5 0.988 -0.26453 0 0 0 0 0 0 0 0 0 8.40058 8.76703 0 0 0 0 A0A8I3QFJ6 A0A8I3QFJ6_CANLF Uncharacterized protein SCGB1C1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] VGSPEELYEGPLGK 1 14.7 0.99078 -0.21011 0 0 0 0 0 0 0 10.9277 0 0 0 0 0 0 0 A0A8I3QFL9 A0A8I3QFL9_CANLF Acyl-CoA thioesterase 9 ACOT9 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] ESMLYLDGKRH;LEDLDSLGVLICYMH;NIFNRIFGGFL 3 8.4 1.0009 -0.62849 0 9.99294 0 0 10.3327 0 0 0 0 0 0 0 0 9.5072 0 A0A8I3QFP0 A0A8I3QFP0_CANLF RNA binding motif protein 26 RBM26 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DADPSALAKYVLALV;EITKEEER;ESDREDLLPHFAAA;SRYRENRSRDERKKD;TESWSEFHED;TSPKVMQPLV;VSKPSVSATEKV 7 8.6 0.94282 0.07627 0 0 0 0 0 0 0 0 8.57988 0 0 0 0 0 0 A0A8I3QFQ7 A0A8I3QFQ7_CANLF Uncharacterized protein RCHY1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] FKVKEVQCINCEKIQ;NVSRQNCPICLEDI;TVQFHILGMKCNICE;VLPCGHLLHRTCYEEMLKE 4 24.3 0.98706 -0.22981 0 0 0 0 0 0 10.8586 0 0 0 0 0 0 0 0 A0A8I3QG09 A0A8I3QG09_CANLF Uncharacterized protein SRGAP2 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; signal transduction [GO:0007165] AEIEMDYSRNLEKLAE;AKRRANQQETEQFYFTK;EEKQIGKSVKQEDRQTPRSPD;KRESRDHTTLSDIYLN;TSPAKFKK;YIVVQDTEDGVVERSSP 6 9.8 1.0022 -1.1551 0 0 0 0 0 0 9.31211 4.9348 11.2543 0 0 0 9.47527 0 0 A0A8I3QG26 A0A8I3QG26_CANLF Transmembrane protein 230 TMEM230 Canis lupus familiaris (Dog) (Canis familiaris) synaptic vesicle transport [GO:0048489] autophagosome [GO:0005776]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] LPGFYHLRIAYY;PKIPYKAIALATVLFLIGAFLIII 2 30 0.93519 0.091743 0 0 0 0 0 0 0 0 9.68126 6.26976 0 0 0 0 0 A0A8I3QG55 A0A8I3QG55_CANLF Fc receptor like B FCRLB Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of immune response [GO:0050777] cytoplasm [GO:0005737] PEPEVDEL;PWLQLAGRGSALP;RCDGYHPLLL;VDELESYWCEAAT 4 9.5 0.98814 -0.47022 10.6388 0 0 7.99701 0 0 0 0 10.1601 12.0369 0 0 0 0 0 A0A8I3QGB2 A0A8I3QGB2_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD9 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CEFPFGSKQKEVCINPYHYRR;SLVKKLKK 2 8.4 0.97783 0.047846 9.69507 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QGG9 A0A8I3QGG9_CANLF Receptor like tyrosine kinase RYK Canis lupus familiaris (Dog) (Canis familiaris) axon extension involved in axon guidance [GO:0048846]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of axon extension involved in axon guidance [GO:0048843]; positive regulation of MAPK cascade [GO:0043410]; skeletal system morphogenesis [GO:0048705] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; frizzled binding [GO:0005109]; protein kinase activity [GO:0004672]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] LLPLLPAPGAAAAP;LVQCLTEFH;PPPLPLLLLLALLPLL;QTTQYLRADTPNNA 4 8.5 1.0022 -0.76649 0 0 9.70587 0 8.04352 0 0 0 0 0 0 0 0 0 0 A0A8I3QGL7 A0A8I3QGL7_CANLF Large ribosomal subunit protein uL4m MRPL4 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] NAVAEEAVPQAAKPEAVGSAGPQ 1 10.5 0.97641 0.04644 0 0 0 0 0 0 0 0 0 6.73742 0 0 0 0 0 A0A8I3QGM8 A0A8I3QGM8_CANLF Double-stranded RNA-binding protein Staufen homolog 2 STAU2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule [GO:0005874] RNA binding [GO:0003723] GGGGGGGA;GGGGGGGG;KKLPPLPVVEKPKLFF;LLMNGTSPTAE;RELLMNGTSPTAEAIGL;TVGNNEFFGEGKTRQAA;VEKPKLFFKK 7 7.7 0.9885 -0.475 0 10.4653 9.60079 0 0 0 0 0 0 0 4.62211 9.52264 0 5.84187 5.5735 A0A8I3QGT3 A0A8I3QGT3_CANLF HHIP like 2 HHIPL2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] GDERGFLGLAFHPKFQCNRKFYIYY 1 3.6 0.97949 0.035538 0 0 0 0 0 0 0 0 9.18239 0 0 0 0 0 0 A0A8I3QH24 A0A8I3QH24_CANLF Interferon induced transmembrane protein 5 IFITM5 Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282]; bone morphogenesis [GO:0060349]; in utero embryonic development [GO:0001701] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] KCYNILATMWAL;LVPPLLLLALVVTGALHLSRLA 2 24.6 0.93589 0.097139 0 8.71973 0 0 0 0 0 0 8.94281 0 0 0 0 0 0 A0A8I3QHA2 A0A8I3QHA2_CANLF "Mannose-6-phosphate receptor, cation dependent" M6PR Canis lupus familiaris (Dog) (Canis familiaris) protein targeting to lysosome [GO:0006622] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020] protein domain specific binding [GO:0019904] AAPFARDTMFPFFSRWRT;GVGDDQLGEESEER;LTRVPGPGSAA 3 10.9 0.99378 -0.17583 0 7.25597 0 8.32296 0 0 0 0 0 0 0 0 0 0 4.81008 A0A8I3QHX9 A0A8I3QHX9_CANLF Junctophilin JPH1 Canis lupus familiaris (Dog) (Canis familiaris) muscle organ development [GO:0007517] junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018] structural constituent of muscle [GO:0008307] EGVDAKENPEEK;HADAELAGK;KNNILVRGIRKQLIP;RGEWSHGFKGRYGV 4 7.6 1.0018 -0.68497 0 9.49388 0 8.55259 0 0 0 0 0 0 9.77362 0 0 0 0 A0A8I3QI81 A0A8I3QI81_CANLF Crooked neck pre-mRNA splicing factor 1 CRNKL1 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245] post-mRNA release spliceosomal complex [GO:0071014]; precatalytic spliceosome [GO:0071011]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007] ADDGSDAGWEEYYD;DYLRLVESDAEAETVREVY;TLPRVNQFWYKYTY;VVGNPWDSVQP;YAQWEESLK 5 10.3 1.0043 -0.81713 0 0 0 0 0 0 11.7298 0 9.04772 0 0 0 7.57092 0 3.89879 A0A8I3QIC9 A0A8I3QIC9_CANLF cAMP responsive element binding protein 3 like 1 CREB3L1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of sprouting angiogenesis [GO:1903671]; positive regulation of collagen biosynthetic process [GO:0032967] chromatin [GO:0000785]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]" VLGSLVPC 1 1.5 1.0042 -1.1044 0 0 0 0 5.05198 0 0 0 0 0 0 0 0 0 0 A0A8I3QIM6 A0A8I3QIM6_CANLF AP-1 complex subunit mu-1 AP1M1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; Golgi apparatus [GO:0005794] clathrin adaptor activity [GO:0035615] LDELMDFGYPQTT;VIIYELLDELMDFGYPQTTDSKI 2 6.6 0.99073 -0.19551 0 0 0 0 0 10.5039 0 0 0 0 10.1711 0 0 0 0 A0A8I3QIR1 A0A8I3QIR1_CANLF NALCN channel auxiliary factor 1 NALF1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] TRDKEQQQQQQQQQRQQQRQQQR 1 5.1 0.97864 0.046253 0 0 0 7.45516 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QIR9 A0A8I3QIR9_CANLF Chromosome 22 open reading frame 31 C26H22orf31 Canis lupus familiaris (Dog) (Canis familiaris) KGKGPVGQ;LIKLVLRRQLK 2 6.4 0.9875 -0.22529 15.9075 0 0 6.68496 6.50892 7.04188 0 0 0 15.6627 15.7737 15.8554 16.1293 16.1332 16.3683 A0A8I3QIS9 A0A8I3QIS9_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) ITGA9 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] AAGGGGGG;GGGGAPPR;GGGGGGGA;GGGGGGGG;GGGGGRSP;LDLIPFFEGLSR;VLDYGKKCVVID 7 7.6 1.0033 -2.1079 9.92302 5.17153 0 0 4.01141 7.74409 6.00767 9.40928 10.2085 7.86944 0 0 5.56989 5.46989 0 A0A8I3QJ22 A0A8I3QJ22_CANLF LARGE xylosyl- and glucuronyltransferase 2 LARGE2 Canis lupus familiaris (Dog) (Canis familiaris) protein O-linked mannosylation [GO:0035269] membrane [GO:0016020] metal ion binding [GO:0046872]; UDP-glycosyltransferase activity [GO:0008194] AAALLLLLLLLLLLL;AAALLLLLLLLLLLLVG;AAALLLLLLLLLLLLVGF;AALLLLLLLLLLLLVG;ALLLLLLLLLLLLV;EDACFEFRQQQ;GAAALLLLLLLLLLL;LGAAALLLLLLLLLLLLV;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLVG;LLLLLLLLLLLV;LLLLLLLLLLLVG;LLLLLLLLLLVGF;LLLLLLLLLV;LSDIDFLPAFSL;TLVAQLSMDRLQ 20 7.6 0.98869 -0.34437 3.56584 9.50835 7.75215 4.08899 0 0 10.3966 6.43773 2.86969 0 5.316 4.4444 7.57864 5.43132 13.5928 A0A8I3QJ76 A0A8I3QJ76_CANLF Ras and Rab interactor 2 RIN2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904906]; positive regulation of vasculogenesis [GO:2001214]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AELHSRPQ;DLGRTVVESRACSR;EAMLRDFHMADGSW;EDCEEESDQE;EKKVMLLLR;YLSQSSELDPPIESLIPE 6 7.7 1.0018 -1.2731 0 0 0 0 0 0 8.80822 10.9917 0 0 0 0 9.49845 13.7234 0 A0A8I3QJ90 A0A8I3QJ90_CANLF Anaphase-promoting complex subunit 13 (Cyclosome subunit 13) ANAPC13 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein K11-linked ubiquitination [GO:0070979] anaphase-promoting complex [GO:0005680] ESVKEQEMKWT;SVKEQEMKWTDLALQ 2 21.6 0.94164 0.070797 0 0 0 0 0 0 0 0 11.9743 0 0 3.78952 0 0 0 A0A8I3QJA9 A0A8I3QJA9_CANLF Doublecortin domain containing 1 DCDC1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412] microtubule binding [GO:0008017] DISKGDQNIGPNTQYIQ;VIKTMEDYL 2 6.7 0.85894 0.14603 0 0 0 0 0 11.8661 0 0 0 0 0 0 0 0 0 A0A8I3QJD8 A0A8I3QJD8_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] RLCWHFFYSHWNLILIVFHYYQAI;VGHYNHRYFF;VYCSYGSWDLFREAY 3 13.6 0.98778 -0.48443 0 8.65739 0 0 0 0 11.5285 0 8.22569 0 0 0 0 0 10.0537 A0A8I3QJL1 A0A8I3QJL1_CANLF G protein-coupled receptor 101 GPR101 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; receptor complex [GO:0043235] G protein-coupled receptor activity [GO:0004930] CCIHPYIYG;CMPLSKMPISL 2 4 0.98765 -0.46195 0 0 0 0 0 0 0 0 0 8.89464 0 0 0 12.5133 0 A0A8I3QJQ7 A0A8I3QJQ7_CANLF Peroxisome biogenesis factor 2 (EC 2.3.2.36) (Peroxin-2) PEX2 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; pexophagy [GO:0000425]; protein destabilization [GO:0031648]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein monoubiquitination [GO:0006513]; response to amino acid starvation [GO:1990928]; very long-chain fatty acid metabolic process [GO:0000038]" Cdc73/Paf1 complex [GO:0016593]; peroxisomal membrane [GO:0005778] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] LVWAQFTQCFHG 1 3.9 0.94675 0.05044 0 0 0 5.82454 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QJR7 A0A8I3QJR7_CANLF Cell division cycle 45 CDC45 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977] DNA replication preinitiation complex [GO:0031261] chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697] CNTCYTAARFKLWS;LHNHFDLSV;MKRRQRREWEARRRDILFDYEQYEY;VGILQRHVSR 4 11.1 1.0027 -1.1917 0 0 6.24112 0 0 0 7.21315 0 0 0 0 0 0 0 0 A0A8I3QJV1 A0A8I3QJV1_CANLF "Renalase, FAD dependent amine oxidase" RNLS Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on NAD(P)H [GO:0016651]" GAQYITRSPQRAGP;QLQGDVANCRTYLLHMDTVSFWRQ 2 19.8 0.99287 -0.2909 0 0 9.66156 0 0 0 0 0 0 0 0 0 0 9.58862 0 A0A8I3QJW1 A0A8I3QJW1_CANLF Ubiquitin-like-conjugating enzyme ATG3 (Autophagy-related protein 3) ATG3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] cytoplasm [GO:0005737] Atg8-family conjugating enzyme activity [GO:0141046] ESKFKETGVI;GEDAILQTRTYD;SAVCEEEEEEDEGEAADMEEYEESG 3 15 0.98915 -0.52548 6.24688 8.37143 5.24435 0 0 0 9.41686 0 11.9316 0 0 0 0 12.1927 0 A0A8I3QJY0 A0A8I3QJY0_CANLF "Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)" AK4 AK3L1 Canis lupus familiaris (Dog) (Canis familiaris) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; GTP metabolic process [GO:0046039] mitochondrial matrix [GO:0005759] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899] DFNPPHVHG;VITRLMMSELENR;VLHQFSGTETNKIWPYVYTLFS;YTLFSNKITPI 4 22.4 1.0019 -1.2061 7.37964 0 0 10.1932 0 0 14.8704 4.43823 5.39393 0 0 0 0 0 0 A0A8I3QKA9 A0A8I3QKA9_CANLF Lipase LIPN Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] "hydrolase activity, acting on ester bonds [GO:0016788]" AYDWGSEAENMHHYNQS;PEVWMNISEIITYNG;TIPQIRNLRYFHL;TQDGYILSINRIP 4 14.6 0.9921 -0.27843 0 0 8.95553 0 0 0 0 0 0 0 8.09851 8.86654 5.6065 0 0 A0A8I3QKG1 A0A8I3QKG1_CANLF ATPase H+ transporting V1 subunit B1 ATP6V1B1 Canis lupus familiaris (Dog) (Canis familiaris) adult behavior [GO:0030534]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; chloride ion homeostasis [GO:0055064]; inner ear morphogenesis [GO:0042472]; olfactory behavior [GO:0042048]; ossification [GO:0001503]; pH reduction [GO:0045851]; potassium ion homeostasis [GO:0055075]; prostaglandin metabolic process [GO:0006693]; regulation of gene expression [GO:0010468]; renal sodium excretion [GO:0035812]; renal sodium ion transport [GO:0003096]; renal water homeostasis [GO:0003091]; sensory perception of sound [GO:0007605]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] "apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microvillus [GO:0005902]; presynapse [GO:0098793]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]" "ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]" AAGPLIRHRALAAP;KSKAVLDYHDDNFAI;LAYQCEKHVLV;LPDGTQRSGQVLEV;NFAIVFAAMGVNMETARFFKSDFEQ;PGGAAAGP 6 13.7 1.002 -1.3634 9.04655 0 10.1047 0 0 0 0 8.51877 8.68587 10.0823 0 0 8.83067 0 0 A0A8I3QKJ7 A0A8I3QKJ7_CANLF Mitochondrial ribosomal protein S28 MRPS28 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543] mitochondrion [GO:0005739] PEVDGEKYQKGTRVRLRLL 1 10.5 0.95245 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.80266 A0A8I3QKP9 A0A8I3QKP9_CANLF Ras association domain family member 7 RASSF7 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] SEHTTCQE;VSRALEAAEHALQDL 2 5.8 1.0048 -1.0505 0 6.37558 0 0 0 0 0 0 0 0 0 6.15431 0 0 0 A0A8I3QKQ9 A0A8I3QKQ9_CANLF Connector enhancer of kinase suppressor of Ras 2 CNKSR2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; membrane [GO:0016020] AKSLLAWLDRSP;QQYIKNFEREKISGDQ;RILKSTLKA;SSALQDLYIPP;VLYCYEYEKGR 5 5.9 0.98742 -0.26014 0 7.21907 0 8.22738 0 0 12.2357 11.4831 11.5809 0 0 12.0885 7.47784 0 7.40803 A0A8I3QKX9 A0A8I3QKX9_CANLF Uncharacterized protein FOXR2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837] PLNYSHLIALA 1 3.5 0.97839 0.035491 4.34241 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QKZ4 A0A8I3QKZ4_CANLF Uncharacterized protein GPR141 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; oxysterol binding [GO:0008142] GIISILFLLVKMN;VGIISILFLLVKM 2 4.7 0.91991 0.11926 0 0 0 0 0 0 0 0 0 0 0 0 0 5.12788 0 A0A8I3QL01 A0A8I3QL01_CANLF DNA topoisomerase (ATP-hydrolyzing) (EC 5.6.2.2) SPO11 Canis lupus familiaris (Dog) (Canis familiaris) meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; reciprocal meiotic recombination [GO:0007131] nuclear chromosome [GO:0000228] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]" DSLKSVKKFALILK;DSLKSVKKFALILKILSKIYKLVQ;VKKFALILKILSKIYKLVQSNTYAT 3 8.4 0.87595 0.13761 5.23009 0 0 0 4.57779 0 0 0 6.76421 0 0 0 6.41596 0 0 A0A8I3QLL6 A0A8I3QLL6_CANLF Pre-rRNA-processing protein TSR2 homolog TSR2 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] AATDGVCP 1 4.2 0.99042 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.3099 A0A8I3QLP6 A0A8I3QLP6_CANLF Uncharacterized protein ZNF280B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] KTDQVLLQHMKDN 1 2.4 0.99081 -0.21084 9.59789 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QLW8 A0A8I3QLW8_CANLF Dual specificity phosphatase 21 DUSP21 Canis lupus familiaris (Dog) (Canis familiaris) axonemal A tubule inner sheath [GO:0160111]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein tyrosine phosphatase activity [GO:0004725] DHIHSVEMQQ 1 5.3 0.99942 -0.61146 0 3.96375 0 0 0 0 0 0 0 0 0 0 0 8.56343 3.60205 A0A8I3QLZ0 A0A8I3QLZ0_CANLF BRCA1 associated protein BRAP Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] EERVLKETCDQKDLQ;NHLPAETRQEIQEGQ 2 5.3 0.99277 -0.15026 11.0283 0 0 0 0 0 0 0 0 0 0 0 0 8.46708 0 A0A8I3QMQ6 A0A8I3QMQ6_CANLF Uncharacterized protein LOC102153873 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] VGVKQLIVGV;VTFALVNVTTEI 2 4.8 1.0025 -0.84185 0 12.1874 0 0 0 0 0 0 13.009 0 5.29979 0 9.75362 0 0 A0A8I3QMU8 A0A8I3QMU8_CANLF Striated muscle enriched protein kinase SPEG Canis lupus familiaris (Dog) (Canis familiaris) muscle structure development [GO:0061061] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AEAPRFESIM;DELVRSHESLRATLQ;EGEEQVRICDFGNAQELTPGE;GVSLPLAHPHRAFL;LSPTQNRRSSD;NTSQSATLFLRKVLSV;PALPPPSKS;PSGGLSSSSDSEEEELEELPS;PTAEETLEHPWFKT;QEGAAVPQ;SEDDVATYVVQ;SLDERTRQRSPASDLE;SYTATATNE;TARNLAGEVSCKAELAVR;TPAPAAPTLATL;TPLSEASGRLSAPGR;VLYFHEAF 17 7 1.0028 -2.536 9.56607 0 0 0 0 11.1624 12.0407 10.1525 13.8125 0 3.90323 10.0419 11.3971 0 12.0112 A0A8I3QMZ7 A0A8I3QMZ7_CANLF Protein FAM32A LOC611221 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] AELGVTKRKKKK;GVAELGVTKRKKKKK;VTKRKKKKK 3 16 1.0017 -0.6999 7.51428 0 0 0 0 0 0 0 0 6.11155 6.36182 0 7.58308 0 5.03042 A0A8I3QN72 A0A8I3QN72_CANLF Coiled-coil domain containing 158 CCDC158 Canis lupus familiaris (Dog) (Canis familiaris) HYWLCRFGFTLNFRFLTTKISHDL;QSQLEIIQEQARNQ 2 9.4 0.97435 0.041303 0 0 0 0 0 0 0 0 9.59023 0 0 0 0 0 0 A0A8I3QNA0 A0A8I3QNA0_CANLF GRAM domain containing 1C GRAMD1C Canis lupus familiaris (Dog) (Canis familiaris) TPWKVEPGGDQLRTMTYTI 1 4.1 0.9521 0.049872 7.19604 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QNJ1 A0A8I3QNJ1_CANLF Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29) VPS29 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; endosome membrane [GO:0010008]; retromer complex [GO:0030904] LIHGHQVIPWGD;VLMDIQASTVVTYVYQL 2 15.9 0.98267 -0.24818 0 0 0 0 0 0 0 0 0 0 6.32998 0 0 0 0 A0A8I3QNL4 A0A8I3QNL4_CANLF EWS RNA binding protein 1 EMID1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] EKSQWAPSLQSFLQQQ;LLPRDDRVGGQGLPGPTGPKG;PMGIPGSPGHMGPPGPTGPKG;RNWCSYVVTRTISCHVQNG 4 16.8 0.81432 0.20113 0 0 0 0 7.4591 6.27006 0 0 0 0 7.58699 0 0 0 6.23953 A0A8I3QNP2 A0A8I3QNP2_CANLF Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) TIMP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] growth factor activity [GO:0008083]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] LVAGEAPP;YLHRSQNRSEEFLVA 2 15.4 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.95954 A0A8I3QNP3 A0A8I3QNP3_CANLF Uncharacterized protein LOC607874 Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type endopeptidase inhibitor activity [GO:0004869] YHSRALRVLRARKQVV 1 10.5 0.96391 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 4.28577 0 0 A0A8I3QNU6 A0A8I3QNU6_CANLF Small ribosomal subunit protein eS1 RPS3A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730] structural constituent of ribosome [GO:0003735] GCVFEVSLADLQ;MMEIMTREVIRKDIE 2 12.2 0.9958 -0.0848 0 0 0 0 0 11.6699 0 0 0 0 0 0 0 0 0 A0A8I3QNZ8 A0A8I3QNZ8_CANLF NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) DUOX2 Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; peroxidase activity [GO:0004601] GSGPGFGI;GVYMRNASCHFQM;IREVEENDHQDLVSVHIYITQLAE;KDGNGYLSFREFL;LESHGDPGS;LVQRYDGWFNN;TQGLPQCVPLTV 7 5.9 0.9801 0.035491 0 0 0 0 0 0 0 0 0 0 0 8.44948 0 0 0 A0A8I3QPA3 A0A8I3QPA3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; monoatomic ion homeostasis [GO:0050801]; negative regulation of sodium ion transport [GO:0010766]; positive regulation of potassium ion import across plasma membrane [GO:1903288] cytosol [GO:0005829] ATP binding [GO:0005524]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674] DLEAAFLSRDVDDGSGSP;ELRRLREKHLKEIQ;FQVSVAMDDVQK;GVSVAAPQSAPPEPP;HYRKSVRSRSRHEKTSRPKLRI;IPVSTALASAVGSV;NSHCCCCP;NTVGGTVN;SGSTVSSIGTLPS;VAAQPSVVPVHSGAHFLPVGQ 10 6.2 1.0033 -1.1044 0 0 4.42163 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QPB8 A0A8I3QPB8_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2C1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613] AVDLSIDESSLTGETTPCSK;LYSKTSQSVSG;NLILKILVSSIIIVCG;QEYRSEKSL;RARAPLAAEVVATKLGPRRA 5 6.7 1.002 -1.2431 0 11.0929 13.9858 10.1619 0 0 0 11.8602 9.62044 10.466 13.9535 0 0 13.1471 13.3341 A0A8I3QPC2 A0A8I3QPC2_CANLF Calpain 10 CAPN10 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to insulin stimulus [GO:0032869]; positive regulation of glucose import [GO:0046326]; positive regulation of insulin secretion [GO:0032024]; proteolysis [GO:0006508]; type B pancreatic cell apoptotic process [GO:0097050] cytosol [GO:0005829]; mitochondrion [GO:0005739] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] EAGHLQSLY;EQVWQEEAG 2 2.5 1.0036 -1.1064 0 0 9.13906 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QPF8 A0A8I3QPF8_CANLF Calpain 10 CAPN10 Canis lupus familiaris (Dog) (Canis familiaris) EDITWRRPQVPVDGGGP 1 12.8 0.98384 -0.25521 0 0 0 0 0 0 8.53275 0 0 0 0 0 0 0 0 A0A8I3QPJ3 A0A8I3QPJ3_CANLF BH3-interacting domain death agonist BID Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] CSYSWMVGREVDSESQ 1 8.2 0.95551 0.049233 0 0 0 7.84235 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QPJ6 A0A8I3QPJ6_CANLF Mannosyltransferase (EC 2.4.1.-) PIGB Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506]; mannosylation [GO:0097502] endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] IMMPCHSTPYYSHV;LHLLGKDSV;YGYLTWEWTERLRGYTYPLIFASI 3 8.8 0.99391 -0.1645 0 0 10.257 0 0 0 0 11.1144 0 0 0 0 0 0 7.27826 A0A8I3QPL0 A0A8I3QPL0_CANLF CST complex subunit CTC1 CTC1 Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" single-stranded DNA binding [GO:0003697] CVKTVWLSQGKNQGF;DGQLALCLAYQ;EILEEPHHCPLQKYTRLQTPC;PLQKYTRL;RHHQLLQHSSP;VGPGPPTPLLFEEGGP 6 6.2 0.98675 -0.37981 0 8.40173 9.34132 0 0 0 0 0 0 0 0 0 10.2879 8.97854 0 A0A8I3QPP2 A0A8I3QPP2_CANLF DNA polymerase (EC 2.7.7.7) POLA1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic DNA replication initiation [GO:1902975] nuclear lumen [GO:0031981] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] ALWMNSQGGRKM;DIDQEDDSSFSAQ;GAMDFEDGDFDEPME;GVFKSLLLL;GVFKSLLLLKKKKYGALVVEPTS;ICEEPTCQNRTRRL;IDDKEDSGAMDFEDGDFDEPMEAE;LLLKKKKYGALV;NICFTTVQRVASE;TVSYVICQDGSNLT 10 8.2 1.002 -1.3016 6.23364 0 9.66197 0 7.81737 0 8.73488 0 0 0 0 0 8.90078 7.19997 0 A0A8I3QPW1 A0A8I3QPW1_CANLF cGMP-dependent protein kinase (EC 2.7.11.12) PRKG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692] DCMYPVEYGKD;ELEEDFAQVLMLKEE;SNFDSFPEDNDEPPPD 3 6.3 0.98958 -0.50915 0 0 0 0 0 0 9.80624 0 0 0 0 0 0 0 8.71569 A0A8I3QPY0 A0A8I3QPY0_CANLF Ectonucleoside triphosphate diphosphohydrolase 7 ENTPD7 Canis lupus familiaris (Dog) (Canis familiaris) CTP catabolic process [GO:0006254]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; regulation of immune response [GO:0050776]; T-helper 17 cell differentiation [GO:0072539]; UTP catabolic process [GO:0046052] cytoplasmic vesicle membrane [GO:0030659] CTPase activity [GO:0043273]; GTPase activity [GO:0003924] VVLLAIILYLLRLRR 1 2.5 0.95119 0.053874 0 0 0 3.50348 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QQ29 A0A8I3QQ29_CANLF Nuclear receptor subfamily 2 group F member 6 NR2F6 Canis lupus familiaris (Dog) (Canis familiaris) detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; entrainment of circadian clock by photoperiod [GO:0043153]; neuron development [GO:0048666] nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AQAALPLHTAPLLAAAGL;GGGGGGGD;NGVDKAGG;PAAAGRFG;PGGGGGGG;SGKHYGVFTCEGC 6 13.5 0.98658 -0.4192 0 9.36608 0 0 12.9467 0 0 0 0 0 8.46895 0 0 0 0 A0A8I3QQ58 A0A8I3QQ58_CANLF Uncharacterized protein LOC491793 Canis lupus familiaris (Dog) (Canis familiaris) LEEWVTSETST;SHMLWFLMRHL;TCLVYSHDGTELLA 3 6.1 0.988 -0.2252 0 0 0 0 0 12.62 0 0 0 0 0 0 0 0 0 A0A8I3QQ61 A0A8I3QQ61_CANLF NALCN channel auxiliary factor 2 NALF2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLAVVASPG;PFILPDNEEMVYGGLPGFIC;PGKDAAALTICCCCCCW 3 9.7 1.0013 -0.70792 0 0 0 0 0 0 6.69891 5.64178 4.38087 0 0 0 0 0 0 A0A8I3QQ76 A0A8I3QQ76_CANLF Teneurin transmembrane protein 1 TENM1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] ATAITVTLALLLAYVIAVHLF;AVNLIYTFAWN;DDCSTNCNGNGECISGHCHCF;DPEGHLTNATFP;EQCIDPTCFGHGTCIMGVCICVP;GDGLTDCVDPDCCQQ;GDQCLPFDQSHCGD;GVCICVPG;GVNVSFLHHSDYGFTISR;ISLPGEHNA;IVLQISEN;KQLNLLPKPF;LHHSDYGF;LSDSANNIHF;SSGEEYYV;TQGMFSLMEFCETP;VFCTNWLWHFLFK;VGKIQDVAKYTTDIGSWLELF;VHIRRDAGGMPL 19 8.7 0.94689 0.061408 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.3208 A0A8I3QQD8 A0A8I3QQD8_CANLF Dickkopf WNT signaling pathway inhibitor 2 DKK2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263] extracellular space [GO:0005615] co-receptor binding [GO:0039706] AFGGSKKG 1 3.1 1.0031 -1.1044 0 0 0 0 0 11.3907 0 0 0 0 0 0 0 0 0 A0A8I3QQE4 A0A8I3QQE4_CANLF DENN domain-containing protein 11 (Protein LCHN) DENND11 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] EDLFVLFFLEQNNRI;KFALLRKRILI;MKFFGEQILILWKFALLRKRILI 3 10.8 0.86335 0.13565 0 7.62512 0 4.26888 0 0 0 0 0 0 0 0 0 0 6.82248 A0A8I3QQE6 A0A8I3QQE6_CANLF Brain enriched myelin associated protein 1 BCAS1 Canis lupus familiaris (Dog) (Canis familiaris) myelination [GO:0042552] EVDLGISVKEDNVATSSPKT;SSPKTMEISAVADAN;SSPKTMEISAVADANGKNL;TSSPKTMEI;VEPAVVEANSLQ;VGKSKCMGKCVFS 6 9.2 1.0026 -1.3752 0 0 0 4.14348 0 0 0 7.96999 0 8.61375 0 0 0 13.1274 9.79175 A0A8I3QQG7 A0A8I3QQG7_CANLF Fc receptor like 6 FCRL6 Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897] MHC class II protein binding [GO:0042289]; protein phosphatase binding [GO:0019903] NVTWQDEDEEA 1 2.8 0.9868 -0.23498 9.0886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QQI3 A0A8I3QQI3_CANLF Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cilium assembly [GO:1902017] centriole [GO:0005814]; centrosome [GO:0005813]; motile cilium [GO:0031514]; spindle pole [GO:0000922] PSCGKNGV;VNVRRSVRVKTKNPP 2 3.6 0.98796 -0.48707 0 0 0 0 0 0 0 0 9.39635 0 0 0 0 10.4316 0 A0A8I3QQK8 A0A8I3QQK8_CANLF GDNF family receptor alpha-2 GFRA2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] IVVVVVIIIIFFYPREKDKK;IVVVVVIIIIFFYPREKDKKKKK;LAIIIVVVVVIIIIF;SYEDKEKPN;SYISICNREISPTER 5 8.1 0.98808 -0.34556 3.01334 8.87802 0 0 5.30925 7.25635 10.0693 0 0 0 0 0 5.58009 0 0 A0A8I3QQP1 A0A8I3QQP1_CANLF Solute carrier family 18 member A2 SLC18A2 Canis lupus familiaris (Dog) (Canis familiaris) histamine secretion by mast cell [GO:0002553]; histamine uptake [GO:0051615]; locomotory behavior [GO:0007626]; neurotransmitter loading into synaptic vesicle [GO:0098700]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; response to toxic substance [GO:0009636]; serotonin secretion by mast cell [GO:0002552]; serotonin uptake [GO:0051610] centrosome [GO:0005813]; dopaminergic synapse [GO:0098691]; synaptic vesicle membrane [GO:0030672] monoamine:proton antiporter activity [GO:0015311]; xenobiotic transmembrane transporter activity [GO:0042910] KLILFIVFL;NRIGYPIPMFAGFCIMFVSTI;SRKLILFIVFLALLLDNML 3 7.7 1.0021 -1.0013 1.57512 0 5.17548 5.35607 0 0 0 0 0 0 0 0 10.0111 0 5.04045 A0A8I3QQS3 A0A8I3QQS3_CANLF Immunoglobulin superfamily member 1 IGSF1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] EETEIIMPTPKPELWAETNFP;GDDSGVYS;IDDESFFLNNVT;LQDLVFMLFKEG;LVALLLVVLWIRWKCRR;LVALLLVVLWIRWKCRRLRIREAWL;QLVALLLVVLWIRWKCRRL;QQLHAVGREA;SEGVYICRTHIQMLPT;VDGVGLAL;VGTDILPKPVI;YWKETGWSEPSKVL 12 11.1 0.98821 -0.26453 0 0 0 0 0 0 0 9.01145 0 0 0 0 0 0 0 A0A8I3QQT3 A0A8I3QQT3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) STK26 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] NGAQDENNASRNQAIE 1 4.2 0.9887 -0.22389 0 10.8155 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QQT9 A0A8I3QQT9_CANLF protein disulfide-isomerase (EC 5.3.4.1) PDIA2 Canis lupus familiaris (Dog) (Canis familiaris) platelet aggregation [GO:0070527] endoplasmic reticulum lumen [GO:0005788] protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035] LLLALLLLLLGASG;LLTHSMHLV 2 4.4 1.0018 -0.74345 0 0 3.79473 0 0 0 0 0 0 0 0 0 0 0 10.4889 A0A8I3QQX2 A0A8I3QQX2_CANLF Formin 1 FMN1 Canis lupus familiaris (Dog) (Canis familiaris) actin nucleation [GO:0045010] actin filament [GO:0005884]; nucleus [GO:0005634] microtubule binding [GO:0008017] FKDKLEEFFQKAKKEHKMEESHLEN;FRAGQPQLVPG;HILGITMGNQEG;KKNKVKKIIKLL;NKVKKIIKLLD;TAERERLLANLLS;VGCLNKRNAH;VGPSSQCPRKPAIEPSCPMKPLY 8 8.1 1.0014 -0.91972 7.15947 0 11.0745 0 10.8085 0 0 5.35484 2.44755 0 0 9.49773 0 0 10.3144 A0A8I3QQZ4 A0A8I3QQZ4_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKZ Canis lupus familiaris (Dog) (Canis familiaris) "diacylglycerol metabolic process [GO:0046339]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of synaptic transmission, glutamatergic [GO:0051966]" nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143] DLPTPTSPLPTSPCSPTL;ESATYGEHIW;MEPRDGSPEARSS;SGSRNIREGFQQ 4 5.8 0.99712 -0.10874 0 0 0 0 0 5.89416 0 0 0 0 0 0 0 10.7439 6.91707 A0A8I3QR44 A0A8I3QR44_CANLF BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein) BROX Canis lupus familiaris (Dog) (Canis familiaris) KYASRLAGKENITEDEAKE;VHRSLKIAAGIFK 2 9.5 0.99158 -0.1832 0 0 0 0 0 0 0 0 11.4613 0 0 0 0 0 0 A0A8I3QR45 A0A8I3QR45_CANLF Matrix metallopeptidase 17 MMP17 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] KDQLYWRFDEHTR;LDDAMCWSD 2 3.8 0.99051 -0.27336 0 0 0 0 0 0 10.281 0 0 0 0 0 0 0 0 A0A8I3QRD1 A0A8I3QRD1_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] GGMVLLKVKAKVRRYLREQRTV;HSRYYRMAALVYYGFRM;KLVLKLPWTQVGF;LDMTDVAVYGVEVPG;YGATECNCSVGNFD 5 12.6 0.99713 -0.11038 0 6.6064 0 0 8.80109 0 0 11.1711 9.65281 0 0 0 10.3673 0 12.5941 A0A8I3QRI2 A0A8I3QRI2_CANLF Uncharacterized protein GPM6B Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix assembly [GO:0085029]; positive regulation of bone mineralization [GO:0030501]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893] membrane [GO:0016020] RDRKVNSRAEMEIG 1 4.6 0.93588 0.060932 0 0 0 0 0 7.40922 0 0 0 0 0 0 0 0 0 A0A8I3QRK1 A0A8I3QRK1_CANLF CD101 molecule CD101 Canis lupus familiaris (Dog) (Canis familiaris) NMEDSDQGKYLC 1 1.3 0.9416 0.05044 0 0 0 0 0 0 0 0 6.80491 0 0 0 0 0 0 A0A8I3QS28 A0A8I3QS28_CANLF Glycine receptor alpha 2 GLRA2 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200] chloride channel complex [GO:0034707]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211] extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] ALFAFFLE 1 1.8 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.48961 0 0 0 A0A8I3QS56 A0A8I3QS56_CANLF Vestigial like family member 1 VGLL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleoplasm [GO:0005654] PSSAHYKKIYFP;QGADVILRNDS 2 9.3 0.98572 -0.23242 7.96249 0 0 0 8.35918 0 0 0 0 0 0 0 0 0 0 A0A8I3QS63 A0A8I3QS63_CANLF Lymphoid enhancer binding factor 1 LEF1 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070] beta-catenin-TCF complex [GO:1990907]; membrane [GO:0016020] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AVSTTGMMMMMMMMMMMM;GAGGGGGG;GGGGGGGD;GVGQITPPLGW;MMMMMMMMMIAFVWLFV;SVDTSFHPAVSTTGMMMMMMMMMMM;TTGMMMMMMMMMM;VSTTGMMMMMMMMMMMMMI 8 12.8 0.95388 0.04941 0 0 0 0 7.09476 0 0 0 0 0 0 0 0 0 0 A0A8I3QSJ6 A0A8I3QSJ6_CANLF Lipoprotein lipase (EC 3.1.1.34) LPL Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] chylomicron [GO:0042627]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361] heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; metal ion binding [GO:0046872] VDQLVKCSHERSI 1 3 0.99405 -0.16355 0 10.9139 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QSS9 A0A8I3QSS9_CANLF "Mucin 20, cell surface associated" MUC20 Canis lupus familiaris (Dog) (Canis familiaris) hepatocyte growth factor receptor signaling pathway [GO:0048012] ARVPAARLTGASGSVWK;ETQTLSPQ;GGEGGGAAWACPPVARVPA;LVSVSVNPLE;VGTGMTTVET 5 9.5 1.0023 -0.71665 0 0 0 4.81727 10.5465 0 0 10.0755 10.4476 9.59025 0 0 9.47115 5.12209 0 A0A8I3QT29 A0A8I3QT29_CANLF von Willebrand factor A domain containing 2 VWA2 Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023] calcium ion binding [GO:0005509] AGTALLHVY;DLLRSLDG;EDATNGLLSTLSKS;NMPSVPWLEV;VGTEAVRAELEEL;YHQDTLIHWIC 6 8.2 0.98766 -0.40058 0 0 11.5086 0 0 11.5076 9.03403 0 0 0 0 0 0 0 11.254 A0A8I3QT85 A0A8I3QT85_CANLF Dual oxidase maturation factor 1 DUOXA1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] LGTPVQQLNETINYNEEFTWRLGE 1 8.1 0.97408 0.041303 0 0 0 0 9.22992 0 0 0 0 0 0 0 0 0 0 A0A8I3QTE3 A0A8I3QTE3_CANLF Testis expressed 9 TEX9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEKYKLELSKSR;YLFSVFFL 2 4.8 0.98907 -0.26225 9.60454 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QTI1 A0A8I3QTI1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EADYYCLSIGPTLGV 1 12.7 0.95106 0.053887 0 0 0 0 9.04568 0 0 0 0 0 0 0 0 0 0 A0A8I3QTJ1 A0A8I3QTJ1_CANLF V-type proton ATPase subunit E 1 (V-type proton ATPase subunit e 1) (Vacuolar proton pump subunit E 1) ATP6V1E1 Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; synaptic vesicle membrane [GO:0030672]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" IATKKDVDVQIDQ;IATKKDVDVQIDQESYLP;LSDADVQKQI 3 14.3 0.99521 -0.158 11.2853 0 0 0 8.32148 0 0 12.7336 0 0 0 0 0 0 0 A0A8I3QTN2 A0A8I3QTN2_CANLF Mucin-4 Canis lupus familiaris (Dog) (Canis familiaris) MTSEVPTTPPIATDTSAGT;SPTVSQVLTTLMATDT;TLSPSSVSHTPS;TTPITIDTPAST 4 4.8 0.98807 -0.31963 0 0 0 0 10.0869 0 10.0137 6.14627 0 0 0 0 9.68164 0 0 A0A8I3QTY0 A0A8I3QTY0_CANLF Autophagy-related protein 9 ATG9A Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422]; lipid transport [GO:0006869]; protein localization to phagophore assembly site [GO:0034497] autophagosome membrane [GO:0000421]; late endosome membrane [GO:0031902]; mitochondrion [GO:0005739]; phagophore assembly site membrane [GO:0034045] GVTVTVCRSFIPDQHMVFCPEQLL;IDFFRNFTVE;TEASVYQQAEDGK;VPEGSKSPWHHIENLD 4 7.5 1.0012 -0.74534 0 0 0 0 8.4439 0 0 0 0 8.25743 0 0 10.9355 0 0 A0A8I3QUB6 A0A8I3QUB6_CANLF Opa interacting protein 5 OIP5 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" AQCHAVLADSVHLAWDLSR;RGHFCLSSDEMVC 2 15.2 0.98764 -0.22858 0 8.69721 0 0 0 9.34379 0 0 0 0 0 0 0 0 0 A0A8I3QUU3 A0A8I3QUU3_CANLF TRAF family member associated NFKB activator TANK Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical NF-kappaB signal transduction [GO:0043124] LFKPQAKDDINRGAQCVT 1 4.4 0.97307 0.048313 0 0 0 0 0 6.22481 0 0 0 0 0 0 0 0 0 A0A8I3QV90 A0A8I3QV90_CANLF Guided entry of tail-anchored proteins factor 1 (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein) GET1 Canis lupus familiaris (Dog) (Canis familiaris) tail-anchored membrane protein insertion into ER membrane [GO:0071816] endoplasmic reticulum membrane [GO:0005789]; GET complex [GO:0043529] protein-membrane adaptor activity [GO:0043495] AEQEAQMRAEI 1 7.9 0.98938 -0.21789 0 0 0 0 0 0 0 9.76853 0 0 0 0 0 0 0 A0A8I3QVG5 A0A8I3QVG5_CANLF T-box brain transcription factor 1 TBR1 Canis lupus familiaris (Dog) (Canis familiaris) amygdala development [GO:0021764]; cell fate specification [GO:0001708]; cerebral cortex development [GO:0021987]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; conditioned taste aversion [GO:0001661]; gene expression [GO:0010467]; hindbrain development [GO:0030902]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon guidance [GO:1902667]; specification of animal organ identity [GO:0010092] nucleus [GO:0005634] "chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GFRDNYDTIYTGCDMDRLT;LVLHDHPIISTTDNLERS 2 5.4 0.94062 0.10324 7.89833 0 0 0 0 0 0 0 0 0 0 0 0 0 5.99401 A0A8I3QVU0 A0A8I3QVU0_CANLF Trafficking protein particle complex subunit 3 TRAPPC3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891] cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; TRAPP complex [GO:0030008] DFVELPDNHSSLIYSNLL;PDNHSSLI 2 15.8 1.0029 -1.3408 11.6221 0 0 0 0 0 0 8.3156 0 0 0 0 0 0 0 A0A8I3QVU2 A0A8I3QVU2_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) TNKS2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] NAD+ ADP-ribosyltransferase activity [GO:0003950]; nucleotidyltransferase activity [GO:0016779] ADVHAKDK;DPTKKNRDGNTPLD;GRRCAGGGAA;LVSADDVSALLTAAMP;PGLLLRLLALLL;SALPSCYKPQ;TSLHRAAHCGH 7 7.4 1.002 -1.2142 0 0 0 0 6.2093 0 0 0 12.7618 0 0 0 0 4.73352 0 A0A8I3QVV2 A0A8I3QVV2_CANLF GATA binding protein 1 GATA1 Canis lupus familiaris (Dog) (Canis familiaris) basophil differentiation [GO:0030221]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; dendritic cell differentiation [GO:0097028]; eosinophil fate commitment [GO:0035854]; erythrocyte development [GO:0048821]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; myeloid cell apoptotic process [GO:0033028]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of myeloid cell apoptotic process [GO:0033033]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast proliferation [GO:0033687]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; primitive erythrocyte differentiation [GO:0060319]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of primitive erythrocyte differentiation [GO:0010725]; transcription by RNA polymerase II [GO:0006366] nucleoplasm [GO:0005654]; protein-DNA complex [GO:0032993]; transcription repressor complex [GO:0017053] "C2H2 zinc finger domain binding [GO:0070742]; chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; p53 binding [GO:0002039]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]" RPLIRPKKRLIVSKRAGTQC;VFQVYPLLNCMEGIPGGS 2 9.2 0.93237 0.096519 6.85 0 0 0 0 0 0 0 0 6.59314 0 0 0 0 0 A0A8I3QVX9 A0A8I3QVX9_CANLF Teneurin transmembrane protein 1 TENM1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] ATAITVTLALLLAYVIAVHLF;AVNLIYTFAWN;DDCSTNCNGNGECISGHCHCF;DPEGHLTNATFP;EQCIDPTCFGHGTCIMGVCICVP;GDGLTDCVDPDCCQQ;GDQCLPFDQSHCGD;GVCICVPG;GVNVSFLHHSDYGFTISR;ISLPGEHNA;IVLQISEN;KQLNLLPKPF;LENLELTYELLHP;LHHSDYGF;LSDSANNIHF;PSPAAPAPPTSTQDSVHLH;SSGEEYYV;VASYFPAMEAEIQ;VGKIQDVAKYTTDIGSWLELF;VHIRRDAGGMPL 20 9.7 0.997 -4.099 11.8889 0 11.6049 0 9.53702 8.42681 0 13.2586 12.7322 12.4472 9.58722 0 12.8135 0 14.0175 A0A8I3QVY1 A0A8I3QVY1_CANLF PHD finger protein 8 PHF8 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] DKCYKCSVKQGQTLFI;DSPDLDLDGNEGPLALLVSNGS;EIRLVEFNITGTCLNDS;IPTGWIHAVLTPV;KAQKKKYIKKKPLLK;KATLIIRPKFPRKLPRAKP;KCSVKQGQTL;KKKYIKKKPLL;RFMIECDMCQD 9 11.8 0.987 -0.231 7.05192 0 4.77072 0 10.3332 5.66854 12.8658 0 0 0 0 7.30232 0 7.01714 4.07459 A0A8I3QVZ9 A0A8I3QVZ9_CANLF Sodium/potassium-transporting ATPase subunit beta-1-interacting protein (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein) NKAIN3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of sodium ion transport [GO:0002028] plasma membrane [GO:0005886] LHIIVVILGL;LVPCGPGL;PSAHGMMD 3 12.3 1.0002 -2.8202 0 2.43095 0 0 0 0 0 10.7621 0 0 0 8.31931 0 0 0 A0A8I3QW07 A0A8I3QW07_CANLF Solute carrier family 25 member 20 LOC119864695 Canis lupus familiaris (Dog) (Canis familiaris) carnitine transmembrane transport [GO:1902603]; mitochondrial transport [GO:0006839] membrane [GO:0016020]; mitochondrial envelope [GO:0005740] acyl carnitine transmembrane transporter activity [GO:0015227] LVREGITGLYRGM 1 4.3 0.99521 -0.15831 0 0 0 0 0 0 0 0 0 0 0 0 12.2959 0 0 A0A8I3QW14 A0A8I3QW14_CANLF Death effector domain containing DEDD Canis lupus familiaris (Dog) (Canis familiaris) decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; regulation of apoptotic process [GO:0042981] cytoplasm [GO:0005737]; nucleolus [GO:0005730] DNA binding [GO:0003677] DKYLEETSIRYVTPR;DPLERQFERFNQANTILK 2 10.4 0.92896 0.10675 0 0 0 0 0 0 0 9.40045 0 0 0 0 8.28054 0 0 A0A8I3QW15 A0A8I3QW15_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVLGLFLIIMLIIILTTGPLI 1 15.7 0.97559 0.047166 8.25611 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QW23 A0A8I3QW23_CANLF Potassium sodium-activated channel subfamily T member 2 KCNT2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] intracellular sodium-activated potassium channel activity [GO:0005228]; outward rectifier potassium channel activity [GO:0015271] DYYVVILCP;HFLDAICWFPMVYYMVG;MDDAEACF;YYEDAKAYGFKNKL 4 4.3 1.0026 -0.72029 0 0 0 0 4.70127 0 0 0 0 0 0 0 0 0 0 A0A8I3QW31 A0A8I3QW31_CANLF "RTF1 homolog, Paf1/RNA polymerase II complex component" RTF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] DENLDQWTFGSNKNKKKGK;EKEREQELFNRIE;GGQEGSPG;IEKREVLKKRFEIRKKLKT;QELFNRIEKREVLKKRFEIRKKLKT;SSEDEEFHDGYGEDLMGDEEDR;VLKKRFEIRKKLKTAKKK;VYSDDEEEEED 8 13.9 0.95054 0.059456 0 11.0815 9.16498 7.75455 7.08247 4.94696 6.62656 0 0 0 0 0 0 0 0 A0A8I3QW49 A0A8I3QW49_CANLF Triacylglycerol lipase (EC 3.1.1.3) (Pancreatic lipase) PNLIPRP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular space [GO:0005615] metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806] IDKGEESWLANMCKKM;TDRKTRFIIHGFIDKGEESW;TVQKGEEKTVYVY;VGRDWCLYWQLTPGK;WAPKDVNTRLLLYTN 5 14.4 0.99125 -0.54553 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5881 0 A0A8I3QW65 A0A8I3QW65_CANLF "Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase)" AGK Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; sphingosine biosynthetic process [GO:0046512] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758] acylglycerol kinase activity [GO:0047620]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729]; D-erythro-sphingosine kinase activity [GO:0017050] EAQVFGNQLIP;EETPPRPSL;LSGMDVTVVKTDY 3 9.5 1.0018 -0.67703 0 0 0 3.07442 0 0 0 0 9.51013 11.1466 0 0 0 0 0 A0A8I3QW75 A0A8I3QW75_CANLF Hyccin PI4KA lipid kinase complex subunit 2 HYCC2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] GASLSSQPIGTKPSSSSQR;GVVEEWLSEFKAL;GVVEEWLSEFKALPDTQI;PEPNSAAATTEGAEGVN;TISLQEDRLGQAGEG;YSTISLQEDRLGQAGE 6 12.7 0.98702 -0.35587 0 10.8186 11.1087 9.31 9.50938 0 9.10876 8.46275 10.6899 0 0 0 11.3368 10.882 0 A0A8I3QWD5 A0A8I3QWD5_CANLF Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) MBTPS2 Canis lupus familiaris (Dog) (Canis familiaris) membrane protein intracellular domain proteolysis [GO:0031293]; regulation of response to endoplasmic reticulum stress [GO:1905897] cytoplasm [GO:0005737]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] GVVHEIGHGIAAI;LVLKSSVYFKHSYEDWLENNGLSIS;SSSSSFCIIPSL;TLRKSLRWHIFS;VPGINLPVNQLTY;YPGAFVDL 6 23.2 0.94671 0.05044 0 0 0 0 0 0 0 0 0 0 0 8.22723 0 0 0 A0A8I3QWH4 A0A8I3QWH4_CANLF Uncharacterized protein IMMP2L Canis lupus familiaris (Dog) (Canis familiaris) protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465] mitochondrial inner membrane peptidase complex [GO:0042720] serine-type endopeptidase activity [GO:0004252] DIVSLVSPKNPEQKIIKRVIAL 1 12.6 0.97499 0.046904 0 0 0 0 0 0 0 0 0 0 0 0 7.28401 0 0 A0A8I3QWI4 A0A8I3QWI4_CANLF PABS domain-containing protein SMS Canis lupus familiaris (Dog) (Canis familiaris) spermine biosynthetic process [GO:0006597] spermine synthase activity [GO:0016768] DEVVYDEDSPYQ;LQSYDGDSQGQEVD 2 7.3 0.98409 -0.24249 0 0 0 0 0 0 0 0 0 6.75596 0 0 0 0 0 A0A8I3QWP4 A0A8I3QWP4_CANLF Dynein light chain Tctex-type 2B DYNLT2B Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; regulation of cilium assembly [GO:1902017]; regulation of intraciliary retrograde transport [GO:1905799] axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasmic dynein complex [GO:0005868]; interphase microtubule organizing center [GO:0031021]; spindle pole [GO:0000922] dynein intermediate chain binding [GO:0045505] DADTDNYTHDIFMNDSLFC 1 13.2 0.9852 -0.24126 13.4756 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QWQ0 A0A8I3QWQ0_CANLF "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (EC 4.1.1.32) (Serine-protein kinase PCK1)" PCK1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to potassium ion starvation [GO:0051365]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol biosynthetic process from pyruvate [GO:0046327]; oxaloacetate metabolic process [GO:0006107]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to bacterium [GO:0009617]; tricarboxylic acid metabolic process [GO:0072350] cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] carboxylic acid binding [GO:0031406]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264] FGENSRVLEWMFNRINGEA;FWEKEVEDIQKYL;IMHDPFAMRPFFGYNFGK;NWFRKDKEG;PKIFHVNWFRK;QLQNGLNFSAK 6 12.2 1.0017 -1.2497 9.12391 0 0 0 0 7.03408 0 0 0 0 0 0 0 0 8.48301 A0A8I3QX20 A0A8I3QX20_CANLF Clathrin heavy chain like 1 CLTCL1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] LVDLAMPYFIQVMREYL;TRTVGFFSKDAMQHAA;TWKEVCFACVD;VGFFSKDAMQH 4 12.7 0.94645 0.084724 0 0 0 0 0 8.32053 3.45088 0 0 0 0 0 0 0 0 A0A8I3QX44 A0A8I3QX44_CANLF Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) SPICE1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle assembly [GO:0090307] cytoplasm [GO:0005737]; spindle [GO:0005819] DNSELINKLWTDIQ;KEISKHIF;RGGGRKVLKVRKKKTSLK;VLKVRKKKTSLK 4 4.6 0.99403 -0.079885 0 0 0 0 9.27015 0 0 8.482 0 5.38991 0 3.95996 0 0 0 A0A8I3QX50 A0A8I3QX50_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 20 ADAMTS20 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DLSPCNFTMWHPQ;HQYHVMAPTLNYHTS 2 3.5 0.98856 -0.26259 0 15.9615 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QX63 A0A8I3QX63_CANLF Rhomboid-related protein 2 (EC 3.4.21.105) RHBDL2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] EMIPAFGIVRLLIIILII;GVYALMGG;SSIFDPLRYL 3 11.9 1.0032 -1.6675 6.15032 0 6.49702 6.59192 7.02026 0 0 0 0 6.3215 0 6.50107 6.14162 9.04721 0 A0A8I3QX76 A0A8I3QX76_CANLF Protein CUSTOS C12orf43 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] AKKKKKLKKKAK;DLVAATTT;DQASLGTKKKRRKKKAKK;GEAKKKKKLKKKAKKE;GGEAKKKKKLKKKAKKE;TKSAMAAP;VGGEAKKKKKLKKK;VGGEAKKKKKLKKKAKK 8 17.3 0.98446 -0.25728 5.22528 4.138 5.12462 4.59419 6.3865 0 0 0 0 0 0 0 0 0 0 A0A8I3QXD3 A0A8I3QXD3_CANLF Insulin degrading enzyme IDE Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta metabolic process [GO:0050435]; hormone catabolic process [GO:0042447]; peptide catabolic process [GO:0043171]; proteolysis involved in protein catabolic process [GO:0051603] cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EVQLPDSYIVFSGP;EYLLEEFRPDL;LMTEVAWT;QPEVIQNMTEFKR;VLTAEYLLE;YIQKLRAEGPQ 6 5.4 1.0024 -1.1332 0 11.8914 0 0 0 0 7.17911 0 4.7194 0 10.2155 0 0 5.1888 10.9078 A0A8I3QXG9 A0A8I3QXG9_CANLF 5'-nucleotidase domain containing 2 NT5DC2 Canis lupus familiaris (Dog) (Canis familiaris) 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872] GISRRGCCAVR;GKQLFLITN 2 2.3 0.99039 -0.26687 0 0 0 0 0 0 0 0 0 0 10.3099 0 0 0 0 A0A8I3QXP6 A0A8I3QXP6_CANLF 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-ALA synthase) (Delta-aminolevulinate synthase) ALAS2 Canis lupus familiaris (Dog) (Canis familiaris) protoporphyrinogen IX biosynthetic process [GO:0006782] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] 5-aminolevulinate synthase activity [GO:0003870]; pyridoxal phosphate binding [GO:0030170] LGMSRHPRVLQA;LQDGKSKIVQK;SPQMMEDFVQKLL 3 6.5 0.99247 -0.19165 0 0 0 0 0 0 9.8831 0 9.59574 0 0 0 0 0 0 A0A8I3QXR9 A0A8I3QXR9_CANLF Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) KCNA5 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] intercalated disc [GO:0014704]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] ACPSKAEFS;DTSRETDLWLGGLD;HHQRVLINI;IFFLFIGVILFS;LDTSRETDLWLGGLD;LDTSRETDLWLGGLDG;LRRPVNVSLDVFADE;SLAILRVIRLVRVFRI;SLAILRVIRLVRVFRIFKLSRHSK 9 13.1 1.0025 -1.1727 0 13.3156 9.88975 0 12.8122 0 13.8865 0 12.441 5.72618 0 9.16463 0 0 0 A0A8I3QXZ9 A0A8I3QXZ9_CANLF Syntaxin 10 STX10 Canis lupus familiaris (Dog) (Canis familiaris) Golgi vesicle transport [GO:0048193] membrane [GO:0016020] GGCKASRESPLLWQ 1 8.5 0.93675 0.060945 0 0 0 0 0 0 0 0 0 0 9.11027 0 0 0 0 A0A8I3QY70 A0A8I3QY70_CANLF Acetoacetyl-CoA synthetase (EC 6.2.1.16) AACS Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] cytosol [GO:0005829] acetoacetate-CoA ligase activity [GO:0030729]; ATP binding [GO:0005524] IPNSVFLDDFL;KKVVLIPYISSK;LKKVVLIPYISSK;MAVEAWNEEGKAVWGESGELVCT;WNWMVSALATG 5 8.6 0.98527 -0.43074 0 0 0 0 0 0 0 0 0 0 6.45781 2.5523 0 0 5.1861 A0A8I3QY97 A0A8I3QY97_CANLF Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) TRMT112 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]; transcription initiation-coupled chromatin remodeling [GO:0045815]; tRNA methylation [GO:0030488] nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991] protein heterodimerization activity [GO:0046982]; protein methyltransferase activity [GO:0008276]; tRNA methyltransferase activator activity [GO:0141106] PNMLLSDEETET 1 9.6 0.95426 0.05044 0 11.2714 0 0 0 0 0 0 0 0 0 11.7803 0 0 0 A0A8I3QYD0 A0A8I3QYD0_CANLF Ubiquitin-like domain-containing protein UBC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] FAGKQLEDGRT;KSSPFSAFL 2 7.2 1.0035 -0.80421 8.90391 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3QYS0 A0A8I3QYS0_CANLF Uncharacterized protein LOC612524 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] PIPITPGFEQAQKVLCLPGK 1 10.6 0.95908 0.049084 0 0 0 0 0 0 0 0 8.06684 0 0 0 0 0 0 A0A8I3QYW7 A0A8I3QYW7_CANLF G protein-coupled receptor 35 GPR35 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GTCARPHPTWVE;HYPAARFPG;RPWTETRVYMV 3 5.2 0.98981 -0.22289 0 0 0 0 0 0 0 0 0 0 0 4.39985 0 0 10.6793 A0A8I3QYZ1 A0A8I3QYZ1_CANLF Kinesin family member 21A KIF21A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ACVSPSDRDFM;DKAFTFDYVFDIDSQQ;DLFDTTRDIDAKN;EVSDHEEEEEEEEEEEDDI;GRLKQTEIT;GVVPGHPVLL;IDLAKKDLEKLKRKEKKKKK;LDALLGHALQENVEDST;LKRKEKKKKKSV;QEVSDHEEEEEEEE;RKLSSSDTPVQDMGSTAAAVEA;SPLQCIHIAEGHT 12 9.3 0.95236 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.40674 A0A8I3QZ05 A0A8I3QZ05_CANLF Stress-induced-phosphoprotein 1 (Hsc70/Hsp90-organizing protein) LOC119875949 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] Hsp90 protein binding [GO:0051879] HVLYSNRSAAYA;LDLDSNCKEAADGY 2 4.8 0.98985 -0.2022 0 0 0 0 0 0 0 0 0 6.9241 0 0 7.88454 0 0 A0A8I3QZ52 A0A8I3QZ52_CANLF "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor" NF2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of organelle assembly [GO:1902115] adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; microvillus [GO:0005902]; plasma membrane [GO:0005886] actin binding [GO:0003779]; integrin binding [GO:0005178] AEMEYLKIAQDL;DILHNENSD;EEPVTFHFLAKFYPENAEEELV;EVLDHDVS;LAQEELLPKRVINLY 5 12 1.0011 -0.92591 0 0 0 0 0 0 10.7424 0 0 0 0 0 0 9.5775 0 A0A8I3QZE3 A0A8I3QZE3_CANLF Attractin like 1 ATRNL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAEQTEFLRGPLEPQRSDSAQEIE;GGGGGGGA;GGGGGGGG;GHSTCINNNVCEQC;IEGYPNAVLRLRF;LDEIQKYTQQ;QSWSTKTPTVL;TAGTISGEETPI;VGGGGGGG;VGGGGGGGG;WSFIQCPACQCN 11 8.1 0.974 0.041303 0 0 0 0 0 0 8.16902 0 0 0 0 0 0 0 0 A0A8I3QZF5 A0A8I3QZF5_CANLF Argonaute RISC catalytic component 3 AGO4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] P-body [GO:0000932]; RISC complex [GO:0016442] miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] DLVPECRKWW;EACISLEKDYQPGIT;FPLQLENGQTVERTVAQ;GADVTHPPAG;TVRVQRPRQEIIQDLASMV;VGSMDAHPSRYCATVRV 6 10.3 0.99899 -0.61146 0 0 0 0 0 0 11.2161 0 0 0 0 0 0 0 0 A0A8I3QZH0 A0A8I3QZH0_CANLF NHS actin remodeling regulator NHS Canis lupus familiaris (Dog) (Canis familiaris) AHPESVDVLTAQSNSP;APTDQAQPPHGEAPA;DCSEAPSSPSAQEHQPALGLA;DIQLTHRRV;GGSADPPPPLQPPGRRDEAV;GHRANSFTSTVAD;LHVFTHSKQ;QRRRKLRRRKTISGIPRR;QWLCRQRR;VLQRRRKLRRRKTISGIPRRV 10 8.1 1.0031 -2.2863 0 11.3584 0 0 3.30829 8.16677 0 9.69685 8.78129 16.1108 0 0 7.54967 6.01527 0 A0A8I3RNX3 A0A8I3RNX3_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FTIWLFRFPFCGPRGIRHFFCDIA;LVCADTRVFEANVLAATVL 2 14 0.99121 -0.18587 0 0 9.67502 0 11.476 0 0 0 0 0 0 0 0 0 0 A0A8I3RNY5 A0A8I3RNY5_CANLF Tetraspanin CD37 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HLPRRPRERAYAK;VLPGRWVFR 2 5.4 0.98999 -0.19829 0 0 9.41811 0 0 0 0 0 0 0 4.95075 0 0 0 0 A0A8I3RNZ9 A0A8I3RNZ9_CANLF CNKSR family member 3 CNKSR3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] cytoplasm [GO:0005737]; membrane [GO:0016020] QLCLDLTTT 1 1.7 1.0047 -0.80421 0 0 0 0 0 0 0 0 0 0 9.95776 0 0 0 0 A0A8I3RP01 A0A8I3RP01_CANLF Uncharacterized protein EDDM13 Canis lupus familiaris (Dog) (Canis familiaris) CHHCNTEMD;DWCYCHHCNTE 2 8.2 1.0023 -0.76872 0 3.46074 0 0 0 0 5.72173 0 0 0 0 0 0 0 0 A0A8I3RP16 A0A8I3RP16_CANLF Calpain small subunit 1 CAPNS1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] GAGGGGGG;GGGGGGGG;ISAISEAAAQYNPEPP;SLDKNGTGQIQVNIQEWL 4 27.2 0.98599 -0.23536 0 0 0 0 0 0 7.7765 0 0 0 0 0 0 0 0 A0A8I3RP23 A0A8I3RP23_CANLF Long-chain-fatty-acid--CoA ligase SLC27A5 Canis lupus familiaris (Dog) (Canis familiaris) ligase activity [GO:0016874] AAPDDGGDGDEETDDETDG;DGGDGDEETDDETDGEDGE;EDVFQESYVPAWQDE;GEAGLLLTQVLRHQPFLGYRGAREL;PGHTGAAH;SDCCASQV 6 10.3 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 5.10631 0 A0A8I3RP55 A0A8I3RP55_CANLF Peroxisomal biogenesis factor 11 alpha PEX11A Canis lupus familiaris (Dog) (Canis familiaris) brown fat cell differentiation [GO:0050873]; peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165] peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991] protein homodimerization activity [GO:0042803] AFTRFTNQTQ;MDAFTRFTNQTQG;SLSQDPLEYNVADE;YEISLQMEKIAHNR 4 16.6 0.98648 -0.42724 0 0 12.5599 0 0 8.08071 0 3.48787 0 0 0 0 0 0 0 A0A8I3RP62 A0A8I3RP62_CANLF Splicing factor U2AF subunit (U2 snRNP auxiliary factor large subunit) U2AF2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of RNA splicing [GO:0033120]" commitment complex [GO:0000243]; nuclear speck [GO:0016607]; Prp19 complex [GO:0000974]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701] C2H2 zinc finger domain binding [GO:0070742]; enzyme binding [GO:0019899]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628] PTPVPVVG;VLPEELLDDE 2 3.8 0.9957 -0.57013 0 0 0 0 0 0 0 12.2474 0 0 0 0 0 0 0 A0A8I3RP66 A0A8I3RP66_CANLF Histone H2A H2AX Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via homologous recombination [GO:0000724]; spermatogenesis [GO:0007283] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; male germ cell nucleus [GO:0001673]; nuclear speck [GO:0016607]; nucleosome [GO:0000786]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; XY body [GO:0001741]" damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] VGPKAPAG 1 5.6 0.9896 -0.26592 0 0 0 0 0 10.9073 0 9.99067 10.0902 0 0 0 0 0 0 A0A8I3RP89 A0A8I3RP89_CANLF Uncharacterized protein ZMYND11 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966]; regulation of transcription elongation by RNA polymerase II [GO:0034243] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; transcription corepressor activity [GO:0003714] KDNKHPMY;NCEEEAMYHCCWNTSYCSI;VDVPTIQEVNEGK;WCYNCEEEAMYH 4 7 1.003 -1.5338 0 0 7.52927 0 0 0 6.93121 0 0 0 10.7158 0 0 0 0 A0A8I3RPA9 A0A8I3RPA9_CANLF AT-rich interaction domain 1B ARID1B Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] brahma complex [GO:0035060]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677] AAGGGGGG;CVDEEDEEDE;DEEDEEDEDEDEEDSGKPE;DEEDEEDEDEDEEDSGKPET;DLSGSIDDLPTG;EDEEDEDEDEEDS;ELLVEYFRKCL;ERPSSLPDLSGSI;GGGAAQPG;GGGGAASL;GGGGDGGG;GGGGGGGA;GGGGGGGG;GGGGGGSG;GPSQPCGA;LVLILGKLILL;NVGTSSSA;PGGGGGGG;PGQGPPSGQPPYGGHQP;QSQAAAAA;QVTGPPPQPPPIRREITFP;QYLPSQSQQRY;TECVDEEDEEDEDEDEEDSGKPET;VDEEDEEDEDEDEEDS;VGEAPAAA;YYNQQPQPPHLPPQAQ 26 10.9 0.99691 -5.0919 4.33707 0 0 0 9.61804 0 6.23674 11.7112 7.97985 0 0 11.131 11.2505 9.12539 6.52122 A0A8I3RPB1 A0A8I3RPB1_CANLF Uncharacterized protein LOC100682666 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] CQYEAESEEQFVH;LRNHFPRKVYTCGKCNYFSDRKNNY;QMAELMPAG;RESGSPTAEEGDFSKG 4 20 1.0023 -0.65962 0 0 13.9615 0 6.87418 0 0 0 9.475 0 0 0 0 0 0 A0A8I3RPB8 A0A8I3RPB8_CANLF Zinc finger protein 407 ZNF407 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" DDKGRPSPEDALGRLPGQ;LKEISVSCTIGNV;VEELPEGGA;VGSAQNPEDLKDS;VGSKFKDFRGNISK;VGTPKERKFTCHLCDRSFTE;VSGNGRIEGH 7 4.4 1.0024 -1.1874 0 0 0 8.02564 11.5751 0 0 0 0 0 8.22911 8.21854 0 13.8616 0 A0A8I3RPC3 A0A8I3RPC3_CANLF Aminopeptidase (EC 3.4.11.-) ANPEP Canis lupus familiaris (Dog) (Canis familiaris) peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270] DQSKPWNHYRLP;FSRHYDTPYPLNK;SEFKNVQENTPSNVLI;VISTLSSIASNVIGQSLAWD 4 6.7 0.99278 -0.052284 0 0 7.2502 0 0 0 0 0 0 12.3602 0 0 0 6.12329 11.6364 A0A8I3RPD9 A0A8I3RPD9_CANLF Branched-chain-amino-acid aminotransferase (EC 2.6.1.42) BCAT2 Canis lupus familiaris (Dog) (Canis familiaris) amino acid biosynthetic process [GO:0008652]; branched-chain amino acid biosynthetic process [GO:0009082]; lipid metabolic process [GO:0006629] mitochondrion [GO:0005739] branched-chain-amino-acid transaminase activity [GO:0004084] PAFIRAWVGG;VLELVTPS;WTHEDGVLELVTPS 3 8 1.0026 -1.1985 0 0 12.3858 0 0 0 0 0 0 0 0 0 12.611 9.90052 8.10565 A0A8I3RPE3 A0A8I3RPE3_CANLF Arpin ARPIN Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin nucleation [GO:0051126] QYQERGGRGSPHSPTPSPQP 1 5.5 0.96157 0.048782 0 0 0 0 0 0 0 0 0 0 0 6.37893 0 0 0 A0A8I3RPG5 A0A8I3RPG5_CANLF Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) GABRB2 Canis lupus familiaris (Dog) (Canis familiaris) cochlea development [GO:0090102]; gamma-aminobutyric acid signaling pathway [GO:0007214]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384] chloride channel complex [GO:0034707]; cytoplasmic vesicle [GO:0031410]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; postsynaptic specialization membrane [GO:0099634] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315] SEVNMDYTLT;WIYTTVMTL 2 4 1.0032 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 9.62797 0 A0A8I3RPG7 A0A8I3RPG7_CANLF Endoplasmic reticulum-Golgi intermediate compartment protein ERGIC1 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] PFLTWGCSTHRKR;QRYSYQYTVANKEYV 2 8.6 0.99211 -0.18108 0 0 0 0 0 0 0 0 0 0 9.1178 0 0 0 7.22236 A0A8I3RPI6 A0A8I3RPI6_CANLF Globin domain-containing protein HBQ1 Canis lupus familiaris (Dog) (Canis familiaris) hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ADALTTAVAHLD;AHGKKVADALTTAVAHLD;ALSALSDLHA;ALSALSDLHAYKL;ALTTAVAH;ALTTAVAHL;ALTTAVAHLD;ALTTAVAHLDDLPSAL;AVAHLDDLPSAL;DALTTAVAHL;DALTTAVAHLD;DKFFTAVSTVLTSKY;DKFFTAVSTVLTSKYR;DKIGGHAGDYG;DKIGGHAGDYGGEAL;DLPSALSALSDLHAYKL;DPVNFKLL;DRTFQSFPTTKTYFPHF;DRTFQSFPTTKTYFPHFDLSPG;DRTFQSFPTTKTYFPHFDLSPGSA;EALDRTFQ;FDLSPGSAQV;FFTAVSTVLTSKY;FPHFDLSPG;FPHFDLSPGSA;FPHFDLSPGSAQV;FPTTKTYFPHFD;FPTTKTYFPHFDLSPGSAQV;FTAVSTVLTSKY;FTAVSTVLTSKYR;GEALDRTF;GEALDRTFQ;GEALDRTFQSF;GGEALDRTFQ;GGEALDRTFQSF;GHAGDYGGEAL;GHAGDYGGEALD;GHAGDYGGEALDRTFQ;HAGDYGGEAL;HAGDYGGEALD;HFDLSPGSA;HFDLSPGSAQV;IGGHAGDYGGEALD;KIGGHAGDYGGEALD;KKVADALTT;LPSALSALSDLHAYKLRVD;LSPADKTNIK;LSPADKTNIKS;LSPADKTNIKST;LTTAVAHLD;LTTAVAHLDDLPSAL;PADKTNIK;PADKTNIKST;PHFDLSPGSAQV;PTTKTYFPHFDLSPGSAQV;PVNFKLLSH;RTFQSFPTT;RTFQSFPTTKTYFPHFDLSPGSAQV;SALSDLHA;SALSDLHAYKLRVD;SDLHAYKLRVD;SFPTTKTYFPHFDLSPG;SFPTTKTYFPHFDLSPGSAQV;SLDKFFTAV;SLDKFFTAVST;SPADKTNIK;SPADKTNIKS;SPADKTNIKST;SPADKTNIKSTWDK;SPADKTNIKSTWDKIG;SPADKTNIKSTWDKIGG;SPADKTNIKSTWDKIGGHA;TAVAHLDDLPSAL;TAVSTVLTSKY;TAVSTVLTSKYR;TFQSFPTTKTYFPHFD;TPAVHASLDKFFTAVSTVLTSKYR;TTAVAHLD;TTKTYFPHFDLSPGSAQV;TYFPHFDL;TYFPHFDLSPG;TYFPHFDLSPGSAQV;VDPVNFKLL;VLSPADKT;VLSPADKTN;VLSPADKTNI;VLSPADKTNIK;VLSPADKTNIKS;VLSPADKTNIKST;VLSPADKTNIKSTW;VLSPADKTNIKSTWD;VLSPADKTNIKSTWDK;VLSPADKTNIKSTWDKIG;VLSPADKTNIKSTWDKIGG;VLSPADKTNIKSTWDKIGGH;VLSPADKTNIKSTWDKIGGHA;VLSPADKTNIKSTWDKIGGHAG;VLSPADKTNIKSTWDKIGGHAGD;VLSPADKTNIKSTWDKIGGHAGDY;VLSPADKTNIKSTWDKIGGHAGDYG;VSTVLTSKY;VSTVLTSKYR;YFPHFDLSPGSAQV;YGGEALDRTF 104 88.7 0 9.9462 0 10.2082 0 9.54635 9.9056 8.55348 13.5569 13.0761 13.5325 0 0 2.32849 10.6721 10.551 0 A0A8I3RPJ3 A0A8I3RPJ3_CANLF Leucine rich repeat transmembrane neuronal 3 LRRTM3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of amyloid-beta formation [GO:1902004]; regulation of presynapse assembly [GO:1905606] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978] LDLSGNEIEAFSGP;LVSLQNLYL 2 4 0.91845 0.10983 0 10.0049 0 0 0 0 6.95722 0 0 0 0 0 0 0 0 A0A8I3RPJ5 A0A8I3RPJ5_CANLF Sorting nexin 9 SNX9 Canis lupus familiaris (Dog) (Canis familiaris) cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; plasma membrane tubulation [GO:0097320] cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886] phosphatidylinositol binding [GO:0035091] AGLVAEQGAIEKVKESDKLVATSKI;AMDDGVKE;DDDEWDEDWDDP;DEWDEDWDDP;DKQVTGRFEEEFIKMRMERLQAWMT;QVTGRFEEEFIKM;TGDDDEWDEDWDDPKS 7 12.4 0.97947 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 7.22381 0 0 A0A8I3RPK0 A0A8I3RPK0_CANLF Major facilitator superfamily domain containing 6 like MFSD6L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APLEQVADDSL;LVGAATSAVQ 2 3.7 0.9839 -0.24779 0 0 0 0 8.55036 0 0 0 0 0 0 0 0 0 0 A0A8I3RPK2 A0A8I3RPK2_CANLF Matrix metallopeptidase 20 MMP20 Canis lupus familiaris (Dog) (Canis familiaris) amelogenesis [GO:0097186]; extracellular matrix disassembly [GO:0022617]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] AALEFCTAAPSVS;DEYYSYDERK;GEGLGGDTHFDNAE 3 7.7 1.0027 -0.79759 14.8928 0 0 0 8.94202 0 0 0 0 9.26714 0 0 0 0 0 A0A8I3RPK9 A0A8I3RPK9_CANLF Uncharacterized protein CENPBD1P Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EDVPPALRQ;EEWKMQVSRAINDAINCYRELYK;KLKPLLVYHL;VYPEMLRSIIEEG 4 10.1 1.0019 -0.74121 0 8.75789 0 0 0 4.85175 0 0 0 0 0 0 0 4.67248 8.12065 A0A8I3RPL6 A0A8I3RPL6_CANLF Uncharacterized protein LOC102152013 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FLYHDVMLE;FRDSSQFSQHR;FSIKFQQQQEEHVGEKLLRN;GCCCGAEDVEAPCEQSISVGV;GERPYECSECGKTFSQ;HAGDRPYGCSECGKS;SFTTSSALRYHQRVHTGERPYEC 7 11.7 0.93696 0.092383 14.9322 0 14.9408 0 12.1993 0 9.75947 0 11.6844 15.6143 15.5211 11.5136 15.6353 14.7991 15.8149 A0A8I3RPS9 A0A8I3RPS9_CANLF "RB binding protein 6, ubiquitin ligase" RBBP6 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511] centrosome [GO:0005813]; nuclear speck [GO:0016607]; protein-containing complex [GO:0032991] nucleic acid binding [GO:0003676]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] CCGNSYCDECI;EEEKKKSKLDEFTNDFAKELM;EKERYREWERKYREWYEKYYKIGYA;EQRRLKEE;ERRRSFSRSKSPYS;ETDEAAFEPDYNESDS;KLESTSSK;LVSPPQQIRRGERSCYR;PAAALAPEHS;PIGGVKSTSKTYVISRTE;QDSKKKKKKKEKKKHKKHKKH;RDPFEKERYREWERKYREWYEKYYK;RSVDFRDPFEK;SLLGQSLLH;SVDFRDPFEKERYREWERKYREWYE;VIPCCGNSYCDEC;YVISRTEPVMGTS 17 10.8 1.0038 -2.0262 7.61655 10.2421 9.22867 0 10.4214 9.17729 6.44482 8.76802 0 9.27435 0 0 0 11.0871 6.3826 A0A8I3RPT2 A0A8I3RPT2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor binding [GO:0019838] EQLVVEETTTTQPTTTTET;IKIKQKTIQDTYQNI;QIAQNLHWQNNIC 3 9.3 0.98607 -0.45305 10.942 0 8.49633 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RPT8 A0A8I3RPT8_CANLF DNA-directed RNA polymerase subunit POLR3K Canis lupus familiaris (Dog) (Canis familiaris) termination of RNA polymerase III transcription [GO:0006386] RNA polymerase III complex [GO:0005666] nucleic acid binding [GO:0003676]; RNA polymerase III activity [GO:0001056]; zinc ion binding [GO:0008270] CPGCGNGLI 1 8.3 0.98975 -0.26542 0 0 0 0 0 0 0 0 0 0 0 0 10.3452 0 0 A0A8I3RPU1 A0A8I3RPU1_CANLF Fibronectin type-III domain-containing protein LOC611642 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] VGVGHGERQDPAER 1 2.8 0.93769 0.060951 0 0 0 0 0 8.28323 0 0 0 0 0 0 0 0 0 A0A8I3RPU5 A0A8I3RPU5_CANLF Coronin 7 LOC102152446 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150] TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] GVPSASGDSLRFTPQPSYP 1 13.1 0.95305 0.049471 0 0 0 0 0 0 0 0 0 9.38087 0 0 0 0 0 A0A8I3RPW3 A0A8I3RPW3_CANLF Motile sperm domain containing 3 MOSPD3 Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507] membrane [GO:0016020] SEEGAEGRVVGR 1 5.1 0.94358 0.05044 8.37199 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RPZ6 A0A8I3RPZ6_CANLF Chromosome 16 open reading frame 92 C16orf92 Canis lupus familiaris (Dog) (Canis familiaris) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] membrane [GO:0016020] EAEVCWILDVDFASLAPRRENANV 1 18.3 0.97389 0.041303 0 0 0 0 0 0 0 0 9.91019 0 0 0 0 0 0 A0A8I3RQ03 A0A8I3RQ03_CANLF F-box protein 24 FBXO24 Canis lupus familiaris (Dog) (Canis familiaris) EVYLQSSG;LVEHIISFLPVRDVVALGQ;QTCHYFHEVCDAEG 3 7 0.9222 0.11237 0 0 0 0 0 9.44808 0 0 0 0 0 10.1934 0 0 8.99817 A0A8I3RQ09 A0A8I3RQ09_CANLF Sphingosine-1-phosphate phosphatase 1 SGPP1 Canis lupus familiaris (Dog) (Canis familiaris) ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingosine metabolic process [GO:0006670] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] sphingosine-1-phosphate phosphatase activity [GO:0042392] FSFTLDTWSTSR;ILIPCWCSLVCLSRIYMGM;PGGGRNQCP 3 9 0.99085 -0.5119 0 0 0 0 0 0 9.12872 0 0 0 7.89972 0 0 0 0 A0A8I3RQ13 A0A8I3RQ13_CANLF Zn regulated GTPase metalloprotein activator 1A ZNG1 ZNG1A Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; hydrolase activity [GO:0016787] IETKLREEEEKSG;LINEASRQV;QHVPTTQP 3 8 1.0031 -1.7184 0 0 9.80106 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RQ25 A0A8I3RQ25_CANLF Guanine nucleotide-binding protein subunit gamma GNG5 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; G protein-coupled receptor signaling pathway [GO:0007186] heterotrimeric G-protein complex [GO:0005834] "chitin binding [GO:0008061]; G-protein beta-subunit binding [GO:0031681]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" GILGLTLLLLPLLLPF;VGNKTWKFYDWS 2 7.8 0.98495 -0.24644 0 0 0 0 0 0 0 0 8.63216 0 0 0 0 0 0 A0A8I3RQ29 A0A8I3RQ29_CANLF Phosphodiesterase (EC 3.1.4.-) PDE6B Canis lupus familiaris (Dog) (Canis familiaris) retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165] photoreceptor outer segment membrane [GO:0042622] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" ALADEYEAKL;ETRRGQVL;ETTRKEIVMAMMMTA;IDHRGTNNLYQMKSQNPL;TRERLGKEPADCEEDELGIL;VLYHVRCDKD 6 9.5 1.0019 -1.2619 5.40674 0 10.3707 0 0 0 0 0 9.30957 0 0 0 0 0 10.1998 A0A8I3RQ58 A0A8I3RQ58_CANLF Natriuretic peptide receptor 3 NPR3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; negative regulation of cold-induced thermogenesis [GO:0120163]; osteoclast proliferation [GO:0002158]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; response to ischemia [GO:0002931]; skeletal system development [GO:0001501] membrane [GO:0016020]; protein-containing complex [GO:0032991] chloride ion binding [GO:0031404]; natriuretic peptide receptor activity [GO:0016941]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803] GGGGGGGA;GGGGGGGG;LFNSSSYGDGSWKRGDK;LGAGLLMAFYFFRKKYR;LVGSSGGG;TVKPEFEKFSMEVKSS;VLVLLPQDDSYLFS 7 14.5 0.98691 -0.36492 0 0 0 9.84483 0 0 5.25081 0 0 0 0 0 0 0 10.6352 A0A8I3RQ60 A0A8I3RQ60_CANLF Coatomer subunit delta ARCN1 Canis lupus familiaris (Dog) (Canis familiaris) "protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] AKGKEVDNFVDKL;RFSTETTFLVD 2 5.7 0.92324 0.095108 0 0 0 0 0 0 11.1053 0 0 9.43411 0 0 0 0 0 A0A8I3RQ88 A0A8I3RQ88_CANLF cAMP-responsive element modulator CREM Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] IPTLTQVATI;NSGAPPPG;QNSIPTLTQVATI;VAENESAHMQNQTG 4 11.7 1.0021 -1.8277 0 0 7.44667 0 0 0 11.6189 0 1.41083 0 0 0 0 3.88587 11.5199 A0A8I3RQ96 A0A8I3RQ96_CANLF TNF receptor associated protein 1 TRAP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cellular respiration [GO:1901856]; translational attenuation [GO:0009386] cell periphery [GO:0071944]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein kinase binding [GO:0019901]; unfolded protein binding [GO:0051082] EAGSRGPSAGLD;MGAARHFLRMQQL;QEVKEDIA;RINTLQAVWMMDPKDVGEWQHE;TVQGSVSKHEFQA;VQGSVSKHEFQAE 6 8.2 1.0026 -1.7445 0 10.7819 0 0 0 0 0 0 7.30706 0 0 0 8.1533 0 0 A0A8I3RQA3 A0A8I3RQA3_CANLF Gamma-glutamyltransferase 6 GGT6 Canis lupus familiaris (Dog) (Canis familiaris) GAALCLAVVHPHATGLGATFW 1 4.2 0.94991 0.04991 0 10.4493 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RQA5 A0A8I3RQA5_CANLF "Abhydrolase domain containing 4, N-acyl phospholipase B" ABHD4 Canis lupus familiaris (Dog) (Canis familiaris) ATSYSIKYPE;DSLSARRTLHTFDL;LFTMADDLEQ;MVHGFGGGV;RFRPDFKRKFADFFEDDTISEYIYH;RVKHLILV 6 21.4 1.0016 -1.4663 9.61027 3.33585 10.5768 0 0 0 10.5779 0 0 0 0 10.7639 0 0 10.7731 A0A8I3RQB5 A0A8I3RQB5_CANLF "Transcription factor A, mitochondrial" TFAM Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial nucleoid [GO:0042645]; nucleus [GO:0005634] DNA binding [GO:0003677] ILQKRLKKKALIKKRV;ILQKRLKKKALIKKRVKL;IMSLEKEILQKRLKKKALIKKRVKL;KALIKKRVKLKT;KEILQKRLKKKALIKKRVK;KRLKKKALIKK;KRLKKKALIKKRVKL;KRLKKKALIKKRVKLK;LKKKALIKKRVKLKT;QIMSLEKEILQKRLKKKALIKKRVK;QKRLKKKALIK;QKRLKKKALIKKRVKLKTI;RLKKKALIKKRVKL;RLKKKALIKKRVKLKT;RLKKKALIKKRVKLKTI;RLKKKALIKKRVKLKTIN 16 14 0.93628 0.072896 7.40173 7.2075 7.35023 5.80212 6.73931 3.63366 4.71287 6.5882 0 8.31551 3.6241 8.80255 1.50304 6.42677 7.72731 A0A8I3RQE2 A0A8I3RQE2_CANLF "Large ribosomal subunit protein mL52 (39S ribosomal protein L52, mitochondrial)" MRPL52 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543] mitochondrial large ribosomal subunit [GO:0005762]; nucleoplasm [GO:0005654] structural constituent of ribosome [GO:0003735] DGRPAPPM 1 6.5 0.99013 -0.2636 0 9.34321 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RQF5 A0A8I3RQF5_CANLF WD repeat domain 7 WDR7 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244] TCLSKACASSDK;VISPGVSAEAMQTIST 2 1.9 0.94012 0.075523 11.1025 0 11.2107 9.96167 0 0 10.8017 0 11.2196 10.1927 10.4897 10.5452 11.0307 10.9503 11.0941 A0A8I3RQG0 A0A8I3RQG0_CANLF Myosin heavy chain 8 MYH13 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AEVENSLQESRN;DEQVHSLQ;DLQVEEDKVNGL;EAMQSMLDAEIRSRN;EDMAMMTHLHEPAVLY;EQEKKLRADLERIKKKLEGD;KDEEIEQL;TLTLNSDQVFPMNPPKFD;TVVGLYQK 9 6.1 0.99653 -0.57651 0 0 0 0 0 10.2251 0 0 0 0 0 0 0 10.4995 10.4077 A0A8I3RQG8 A0A8I3RQG8_CANLF "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase)" HDDC3 Canis lupus familiaris (Dog) (Canis familiaris) DTTLDEVELHFGTQVRRLVEEVTD 1 16.8 0.97422 0.041303 0 0 0 0 0 0 0 9.02079 0 0 0 0 0 0 0 A0A8I3RQI4 A0A8I3RQI4_CANLF Phytanoyl-CoA 2-hydroxylase interacting protein like PHYHIPL Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ISNITCDSFKISWEMD 1 4.6 0.95846 0.049233 0 0 6.68818 0 0 0 0 0 0 0 0 7.67638 0 0 0 A0A8I3RQJ6 A0A8I3RQJ6_CANLF Uncharacterized protein IL15RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] interleukin-15 receptor activity [GO:0042010] EDTAENYPHNLE;GPPLRGRRLP;LLLLLLPL;LVCYQKMRQTSQTPQVE;RLPALPALPALLLLLLPLR;VCYQKMRQTSQTPQVEMESMEEV 6 35.4 1.0026 -0.72004 7.22651 9.52585 0 0 7.83156 0 0 7.10633 0 0 0 0 0 11.0965 0 A0A8I3RQL4 A0A8I3RQL4_CANLF Uncharacterized protein ZIM2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GEYSPDDP 1 1.4 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.42206 A0A8I3RQL6 A0A8I3RQL6_CANLF Nucleolar protein 8 NOL8 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] RNA binding [GO:0003723] GASHFQDSSSGEEDV;SFLHRLAQ;TQQEAAQEVP;VLGNEINYDSG;VSPSSLEVERRNP 5 5.2 1.0032 -2.4025 0 0 0 0 0 0 11.2657 0 0 11.6509 6.14262 0 0 0 9.67177 A0A8I3RQM1 A0A8I3RQM1_CANLF Tyrosine-protein kinase (EC 2.7.10.2) FES Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] ISGIFRPKFSNLY;IVMELVQGGD;RHSTSSSEQERE;SPYPNLSNQ 4 5.9 0.99437 -0.077474 0 0 0 0 5.43162 0 12.4039 12.1662 0 0 12.0694 11.9094 0 0 11.2859 A0A8I3RQN0 A0A8I3RQN0_CANLF DNA polymerase epsilon subunit (DNA polymerase II subunit 2) POLE2 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated DNA replication [GO:0006261] epsilon DNA polymerase complex [GO:0008622] DNA binding [GO:0003677] IKYLTEALE;LHQRTHRHELFTPPV;PFTLTNTECLCINP 3 7.6 0.99475 -0.1294 0 7.77985 0 0 0 0 0 0 0 0 0 0 8.26374 6.98425 0 A0A8I3RQN1 A0A8I3RQN1_CANLF Autocrine motility factor receptor AMFR Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; regulation of SREBP signaling pathway [GO:2000638]; ubiquitin-dependent protein catabolic process [GO:0006511] Derlin-1 retrotranslocation complex [GO:0036513]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471] BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450] DQEEGEASVQTERVPLDLSPRLE;LNSPVERPNG 2 5.1 1.0032 -0.89364 0 0 0 9.48927 0 0 0 0 0 0 0 0 0 0 11.0119 A0A8I3RQN4 A0A8I3RQN4_CANLF Solute carrier family 25 member 16 SLC25A16 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743] DGGGGGGGGSGSGRPPSR;GGGGGGGG;GGGGGGSG 3 5 0.99091 -0.1854 0 0 0 0 0 0 0 0 0 0 12.4826 0 0 0 0 A0A8I3RQP2 A0A8I3RQP2_CANLF Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) CDC123 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] SGRNLKGD 1 2.7 0.98792 -0.26481 13.4401 13.4525 0 0 0 0 0 13.5785 13.504 0 13.278 12.8303 0 13.3606 13.3236 A0A8I3RQP5 A0A8I3RQP5_CANLF SKI family transcriptional corepressor 2 SKOR2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] cytoplasm [GO:0005737]; nucleus [GO:0005634] sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332] DDEEEEQEV;DEEEDEEAGV;GAGGGGGG;GGSSPGSP;HKKEDAGAAAEALG;MFWPPRTPGGLP;PGGSGGDC;PGGTSCSYPSEDSSEDEDDEEEEQ;PHAAPAHPHPHP;PSEDSSEDEDDEEEEQEVDVE;SEDEDDEEEEQEV;SEDSSEDEDDEEEEQE;VGAGAGAG;YPSEDSSEDEDDE 14 10.8 1.0016 -2.648 9.54421 4.91174 0 5.03584 0 0 9.80042 8.26496 12.6132 8.19288 0 0 4.58988 9.11405 0 A0A8I3RQP7 A0A8I3RQP7_CANLF Small ribosomal subunit protein uS4 (40S ribosomal protein S9) RPS9 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] KSIHHARVLIRQRHI;VFKLGLAKSIHHARVLIRQ 2 15.8 0.93707 0.10337 0 0 0 0 0 5.1495 0 0 0 0 0 2.90685 0 0 0 A0A8I3RQQ6 A0A8I3RQQ6_CANLF tRNA methyltransferase 11 homolog TRMT11 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737] nucleic acid binding [GO:0003676]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102] FGRWIADGQRELIES;LPVYTPEYTEEM;QGHNSFREKYFSGV;VGTGKASR;VSLSYHLSDMFFDLLNFAAETL 5 16.4 1.0026 -1.1894 4.43236 0 0 0 0 0 8.63238 0 8.70418 0 0 8.42647 9.1052 0 0 A0A8I3RQR0 A0A8I3RQR0_CANLF Centromere protein W CENPW Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278] inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982] LRRLFRRQKPRLRL 1 15.9 0.94068 0.060769 0 0 0 0 4.58574 0 0 0 0 0 0 0 0 0 0 A0A8I3RQS0 A0A8I3RQS0_CANLF E3 SUMO-protein ligase EGR2 (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) EGR2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] PSPKPATD;RVPPPLTPLST;SQCQRDLHG 3 5.9 1.0037 -0.81548 0 0 0 0 0 0 0 13.5338 0 0 0 0 8.58665 0 0 A0A8I3RQS1 A0A8I3RQS1_CANLF "Calcium-activated potassium channel subunit beta (BKbeta) (BK channel subunit beta) (Calcium-activated potassium channel, subfamily M subunit beta) (Charybdotoxin receptor subunit beta) (K(VCA)beta) (Maxi K channel subunit beta) (Slo-beta)" KCNMB1 Canis lupus familiaris (Dog) (Canis familiaris) detection of calcium ion [GO:0005513] voltage-gated potassium channel complex [GO:0008076] calcium-activated potassium channel activity [GO:0015269]; potassium channel regulator activity [GO:0015459] TTVLYRRL;YHTEDTRDRNQQC;YHTEDTRDRNQQCS 3 11.5 1.0031 -1.5064 0 14.6514 10.4756 0 0 0 11.3177 0 0 0 14.3742 12.0573 14.4673 11.0303 0 A0A8I3RQS4 A0A8I3RQS4_CANLF Glutathione S-transferase (EC 2.5.1.18) GSTM3 Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802] PHSLSAPDYDKSQWLDVKF;QIMDFRIQLVQLCYSP 2 15.1 0.94777 0.049553 0 0 0 0 0 0 0 0 0 0 0 0 0 9.65832 0 A0A8I3RQS9 A0A8I3RQS9_CANLF Nuclear receptor binding factor 2 NRBF2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] EEQATKIADL;GVFDRDPDTLLFL;SLELQRDSHMKQL;STEKHLPEIQGVFD 4 16.5 0.99455 -0.56111 0 0 0 10.6338 10.7581 10.8369 0 0 0 0 0 9.72426 0 0 0 A0A8I3RQT1 A0A8I3RQT1_CANLF Nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) (EC 2.7.7.18) NMNAT1 Canis lupus familiaris (Dog) (Canis familiaris) ATP generation from poly-ADP-D-ribose [GO:1990966]; NAD biosynthetic process [GO:0009435]; negative regulation of DNA-templated transcription [GO:0045892]; response to wounding [GO:0009611] chromatin [GO:0000785]; nuclear body [GO:0016604] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768] SLQKEWVET 1 3.2 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 9.63702 0 A0A8I3RQT3 A0A8I3RQT3_CANLF R-spondin 3 RSPO3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] heparin binding [GO:0008201] CDTCFNKNFCTK;CKADCDTCFN;PAGGGGGA;PRVVPGDAP 4 5.6 1.0018 -1.3652 0 0 0 0 0 0 10.9713 0 0 0 0 0 5.75972 0 7.30177 A0A8I3RQV0 A0A8I3RQV0_CANLF Rho guanine nucleotide exchange factor 15 ARHGEF15 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] CDCSQELCSEPSAPA;ELTELGCRRGGVLF;PLPCSPDTVYEDCDCSQ;PQVNLGSSGSQENGTL;SRLMDTNVRFS;TQRLRFHKVKALPL;VGRMKQTEELIRL;VLSEELWGV;VRNQQYQEETYSRLMDT;YEDCDCSQE 10 14.4 1.0032 -1.6445 10.3484 0 0 0 8.99639 8.5619 11.4409 11.1251 7.10266 9.47519 0 6.95303 0 0 0 A0A8I3RQV3 A0A8I3RQV3_CANLF Hyaluronan mediated motility receptor HMMR Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] hyaluronic acid binding [GO:0005540] ELSSSLQQKLCSFQEEMMKERNLF;ENLKEKNH;ETEKLLEYIEEI;KTLGLKIRVLVQ;SLQQKLCSFQEEMMKERNLFEEEL;SPGAYDVKTSE 6 10 1.0031 -1.5829 0 0 0 0 0 0 11.4407 9.00523 0 0 8.28369 0 0 10.0356 0 A0A8I3RQW0 A0A8I3RQW0_CANLF "Short chain dehydrogenase/reductase family 42E, member 2" SDR42E2 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LGLLLLLGLLALALRLLG;LLLLGLLALALRLLGLQPLPAS;LLRLLLGLLLLLGLLALALRLLGL;RLLLGLLLLLGLLALALR;RLLLGLLLLLGLLALALRL;RLLLGLLLLLGLLALALRLL;RLLLGLLLLLGLLALALRLLGL;RLLLGLLLLLGLLALALRLLGLQ;RLLLGLLLLLGLLALALRLLGLQP;TLLRLLLGLLLLLGLLALAL;VGGTKLVINVCVRRRVPR 11 11.6 0.84549 0.19405 7.64703 6.57959 0 0 6.12425 6.49808 0 8.30378 6.10869 6.79818 3.53269 0 9.4707 9.82979 6.23615 A0A8I3RQW6 A0A8I3RQW6_CANLF "MEFV innate immunity regulator, pyrin" MEFV Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of interleukin-1 beta production [GO:0032731]; pyroptosome complex assembly [GO:1904270]; response to type II interferon [GO:0034341] canonical inflammasome complex [GO:0061702]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654] actin binding [GO:0003779]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] AALEYKVKI;MINHYGEENAVRLTLQ 2 2.9 0.98966 -0.3129 0 0 0 0 0 0 0 0 10.2883 0 0 0 0 12.0041 0 A0A8I3RQY5 A0A8I3RQY5_CANLF SOS Ras/Rho guanine nucleotide exchange factor 2 SOS2 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982] EPEMRRFF;FLFDGLMISCKPNHSQSRL;KTEEGNNDF;LKTEEGNNDFL;RFRKEYVQPVQLRI;SLKEVLGYKVDYHVSLY;TFLTTYRSFCK 7 6.6 1.0022 -1.7522 0 0 9.90289 0 0 9.80462 0 0 0 0 8.38418 0 0 0 0 A0A8I3RQY9 A0A8I3RQY9_CANLF Small ribosomal subunit protein uS17 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KKKKKKKK;KKKKKKKV;KKKKKKKVA;PLKKIKLFSQSKKKKKKKKV 4 11.3 0.97198 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.11051 A0A8I3RQZ3 A0A8I3RQZ3_CANLF Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) ADPRM Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] QYKASEKSLELVMNTFQML 1 4.8 0.98288 -0.25198 0 0 0 8.35892 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RQZ6 A0A8I3RQZ6_CANLF TM2 domain-containing protein 3 TM2D3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DRSYSSYNGNCQDS;PETDYECSNST 2 10 0.94018 0.060769 0 0 0 5.36894 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RR00 A0A8I3RR00_CANLF Hydroxysteroid 17-beta dehydrogenase 14 NTN5 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; tissue development [GO:0009888] extracellular region [GO:0005576] GVRGRCQCHGHAARCAAR;GVTGLTCNR;LAVRVLAVYKQRARP;SAAGGPDP;VLSAAWAN 5 11.9 1.0032 -2.317 6.07912 7.5404 0 0 0 0 0 0 0 0 0 9.50287 8.24389 0 0 A0A8I3RR02 A0A8I3RR02_CANLF Tetratricopeptide repeat domain 33 TTC33 Canis lupus familiaris (Dog) (Canis familiaris) NKTMVIVSASGTVE 1 5.3 0.93612 0.060949 0 0 0 0 0 0 8.51302 0 0 0 0 0 0 0 0 A0A8I3RR08 A0A8I3RR08_CANLF "Alpha-2-glycoprotein 1, zinc-binding" AZGP1 Canis lupus familiaris (Dog) (Canis familiaris) HSSLSQPLTVLWDKRQGA;QETKSGGA 2 8.3 1.0036 -1.0561 0 0 0 0 6.32423 0 0 3.93452 0 0 0 0 8.69387 0 0 A0A8I3RR11 A0A8I3RR11_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G2C Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] RCCLVHDCCY 1 5.8 0.99935 -0.61146 0 0 0 0 0 0 0 2.36924 0 0 0 0 0 0 0 A0A8I3RR19 A0A8I3RR19_CANLF Zinc finger protein 628 ZNF628 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; spermatogenesis [GO:0007283] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GVAGGQAFRCGSCDGAFPQL;PAPTPACTERPYK 2 3.2 0.91928 0.10905 11.0862 0 0 0 0 0 0 0 0 0 0 0 0 9.30948 0 A0A8I3RR27 A0A8I3RR27_CANLF Serpin domain-containing protein LOC111097149 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] KYWSGALNCETPL 1 9.6 0.9848 -0.2548 0 0 0 0 0 0 12.2933 0 0 0 0 0 0 0 0 A0A8I3RR42 A0A8I3RR42_CANLF Neuronal PAS domain protein 1 NPAS1 Canis lupus familiaris (Dog) (Canis familiaris) maternal behavior [GO:0042711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; startle response [GO:0001964] nucleus [GO:0005634] protein heterodimerization activity [GO:0046982] FFIRMKSTLTKRG;GGGGGGGE;HRGPMALVSEVFEQH;PGGGGGGG;SAAEAPPFSRVQ 5 8.2 0.99275 -0.16807 0 0 0 0 0 0 0 0 11.2979 0 0 0 0 0 0 A0A8I3RR47 A0A8I3RR47_CANLF BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (Coiled-coil domain-containing protein 64B) BICDL2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase binding [GO:0031267] NQMLQSRRQDLEAQ;RVSELEEESRLRD;SLSFSCCP 3 5.7 1.0025 -1.2002 0 8.93204 0 0 0 0 8.46107 0 0 4.40824 0 0 0 0 0 A0A8I3RR57 A0A8I3RR57_CANLF Solute carrier family 25 member 2 SLC25A2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial L-ornithine transmembrane transport [GO:1990575]; ornithine metabolic process [GO:0006591] membrane [GO:0016020]; mitochondrion [GO:0005739] L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] YHGLSSTLLQEVPGY 1 5 0.95172 0.053885 0 0 0 0 0 0 0 0 7.94146 0 0 0 0 0 0 A0A8I3RR65 A0A8I3RR65_CANLF Ring finger protein 186 RNF186 Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; regulation of autophagosome assembly [GO:2000785] endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625] AHLLLLLGLIILILPFIYPG;HLLLLLGLIILILPFI;RRLAAHLLLLLGLIILILPF 3 10.3 0.8605 0.14564 0 0 0 0 0 0 0 5.11203 3.00547 0 0 0 0 0 8.20428 A0A8I3RR67 A0A8I3RR67_CANLF DnaJ heat shock protein family (Hsp40) member B4 DNAJB4 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018] ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082] GAGGTDGQ;PQAEEKFKEVAEAYE;RTIPMSINDIVKPG 3 11 1.0016 -1.3121 0 0 0 0 8.12076 0 0 8.64839 0 0 0 0 0 0 0 A0A8I3RR71 A0A8I3RR71_CANLF 40S ribosomal protein S25 RPS25 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069] structural constituent of ribosome [GO:0003735] AQVIYTRNTKGGDA;DKLCKEVPNYKLITPAVVSERL;KWSKGKVRDK;RAALQELLSKGLIKLV 4 49.6 0.9894 -0.5205 0 0 0 4.356 0 0 7.73877 0 0 0 0 0 0 0 0 A0A8I3RR78 A0A8I3RR78_CANLF "NBL1, DAN family BMP antagonist" NBL1 Canis lupus familiaris (Dog) (Canis familiaris) determination of dorsal identity [GO:0048263]; negative regulation of monocyte chemotaxis [GO:0090027]; neuron projection morphogenesis [GO:0048812]; positive regulation of neuron differentiation [GO:0045666]; sequestering of BMP from receptor via BMP binding [GO:0038098]; sequestering of BMP in extracellular matrix [GO:0035582] extracellular space [GO:0005615] BMP binding [GO:0036122]; identical protein binding [GO:0042802]; morphogen activity [GO:0016015] PPGAPHAEEEGAED 1 8 0 1.6507 6.10578 8.37738 0 0 6.54266 6.91157 7.58481 0 0 7.92535 7.93681 7.95507 0 0 8.50657 A0A8I3RR79 A0A8I3RR79_CANLF Neuralized E3 ubiquitin protein ligase 1B NEURL1B Canis lupus familiaris (Dog) (Canis familiaris) DTVIYTCGHMCLC;QRPIRLYEQV;SGSQDDSDSDMA;SPPVSPAFSPPEPA;VGGPLWALIDVYGITDEVQ 5 21.6 1.0026 -1.1453 0 9.62324 0 0 0 0 8.17413 0 0 0 0 0 0 0 0 A0A8I3RR88 A0A8I3RR88_CANLF Angiotensinogen (Serpin A8) AGT Canis lupus familiaris (Dog) (Canis familiaris) angiotensin-activated signaling pathway [GO:0038166]; kidney development [GO:0001822]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein metabolic process [GO:0051247]; regulation of cardiac conduction [GO:1903779]; vasoconstriction [GO:0042310] extracellular space [GO:0005615] hormone activity [GO:0005179]; serine-type endopeptidase inhibitor activity [GO:0004867]; type 1 angiotensin receptor binding [GO:0031702]; type 2 angiotensin receptor binding [GO:0031703] MSGISPDSTLL;RVANPLSGV 2 4.1 0.85854 0.14625 0 0 0 0 9.025 0 0 0 0 0 0 0 0 0 0 A0A8I3RR91 A0A8I3RR91_CANLF Ninein NIN Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] calcium ion binding [GO:0005509] EDKVHHYEKQLDET;GFHNQQQRLTWDKMDHLVKEEQQ;HAWDLQLRQQQACPTV;HYEKQLDE;LSLEKSYDEVRRE;MEASEASIESFS;PKVQNQVILEEDTA;QELKQLLEQQL;RTSETNTPQALLPEPRAVH;TLRSLESHYHQ;VLKKKLKML;VLKKKLKMLERIP;YGLQNIDGEIL 13 7.6 1.002 -2.6101 3.35868 0 15.7223 0 3.02098 6.27105 11.4191 4.33543 11.5007 0 10.3799 7.23525 9.26418 0 0 A0A8I3RR92 A0A8I3RR92_CANLF Iroquois homeobox 3 IRX3 Canis lupus familiaris (Dog) (Canis familiaris) atrioventricular bundle cell differentiation [GO:0003167]; energy homeostasis [GO:0097009]; mesoderm development [GO:0007498]; metanephros development [GO:0001656]; negative regulation of neuron differentiation [GO:0045665]; neuron differentiation [GO:0030182]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuron differentiation [GO:0045666]; Purkinje myocyte development [GO:0003165]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; specification of loop of Henle identity [GO:0072086] axon [GO:0030424]; cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GYQYIRPLYPPERPGA;SEREEEDEEEDEED;TDEEGNAYGSEREEED;TSPDNPRRSPPGAGG;VAAVPPSP;YGSEREEEDEEEDEEDSKREL 6 13.3 1.003 -1.385 8.06985 0 0 0 12.3261 8.08539 0 0 0 0 0 0 0 0 4.67271 A0A8I3RR95 A0A8I3RR95_CANLF Peroxisomal membrane protein PEX14 (Peroxin-14) PEX14 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003]" fibrillar center [GO:0001650]; peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991] beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein transmembrane transporter activity [GO:0008320]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714] DEEDEEDEDVSHVD;PEGSTAAY;PEGSTAAYHLLGPQEEGQG 3 8.8 0.98767 -0.4014 0 4.43683 10.8246 0 0 0 0 0 0 0 0 0 13.9444 13.9087 13.9061 A0A8I3RRA1 A0A8I3RRA1_CANLF DLG associated protein 1 DLGAP1 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] postsynaptic density [GO:0014069] CAADDDFDADFDP;EDSGDSDTS;GVIAMKGLSGS;PPPDPWIDSI;RYGKRSKS;SQHMNNNPTT;TVTTTTTIATVT;YHACAADDDFDADFDPS 8 6.8 1.0021 -1.2026 9.26845 0 10.3968 0 0 6.90857 10.3004 0 10.2374 0 10.9695 10.2583 9.41304 0 9.50387 A0A8I3RRA3 A0A8I3RRA3_CANLF Piezo type mechanosensitive ion channel component 1 PIEZO1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] mechanosensitive monoatomic ion channel activity [GO:0008381] DHATVIHSGDYFLFESD;DPKEMLSRDRDCLLPVEE;EEWQHMAGV;ELDDDDDGEV;EQARQDQTGQ;FWLLLRRFVKEKLLKKGKVPAALT;GLEQFSVSELFSSI;LDDDDDGEVDTGSPV;LDHATVIHSGDYFLF;RDIKRISLRFRKR;TEEWQHMAGVNTD;VGLQGAPV;VLLRRLLELHILKLVA;VLTRVQVLLRRLLELHILKL;VTKYLFQFGFFP;VYYSLWRKL;YLFQFGFFPWNTHTVLR 17 7.5 0.99904 -3.1982 11.4574 11.3842 0 0 7.86882 3.97792 8.11712 11.3983 0 9.61712 9.82314 10.331 0 4.28799 5.07823 A0A8I3RRB0 A0A8I3RRB0_CANLF Gastrotropin (Fatty acid-binding protein 6) (Ileal lipid-binding protein) FABP6 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid transport [GO:0015908] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] fatty acid binding [GO:0005504] ISTIGNVTYERV;SEVVGDKLVEI 2 17.2 0.98515 -0.24608 0 0 0 0 0 0 0 10.9783 0 0 0 0 0 0 0 A0A8I3RRB2 A0A8I3RRB2_CANLF Pleckstrin homology and FYVE domain containing 1 PLEKHF1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AEGCNTCC;DGDWPSHVEFYASGVS;SSGDDEDSDEDKEGGGDGD 3 8.6 1.0017 -1.2872 0 0 0 5.71617 0 0 7.19663 0 0 0 0 0 10.0437 0 0 A0A8I3RRB8 A0A8I3RRB8_CANLF Ankyrin repeat and sterile alpha motif domain containing 4B ANKS4B Canis lupus familiaris (Dog) (Canis familiaris) brush border assembly [GO:1904970]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; response to endoplasmic reticulum stress [GO:0034976] brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; microvillus [GO:0005902]; plasma membrane [GO:0005886] LTSLAAFV;SKGIKDTFKLKLKKNKDT 2 5.2 0.98999 -0.217 6.40842 0 0 0 0 0 0 0 0 0 0 0 11.8483 0 0 A0A8I3RRD5 A0A8I3RRD5_CANLF Glutaredoxin 5 GLRX5 Canis lupus familiaris (Dog) (Canis familiaris) [2Fe-2S] cluster assembly [GO:0044571]; protein maturation by [2Fe-2S] cluster transfer [GO:0106034]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035] iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759] DGGGRSAA;SGGDGGGR 2 5.9 1.0022 -1.3703 10.5962 0 0 0 0 0 0 0 0 0 0 0 0 0 8.13422 A0A8I3RRF1 A0A8I3RRF1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FPDALEDTPPHPGGPPLPQAEPL;SQSHPPPQTPVVSLYDP 2 10.2 0.99185 -0.18194 0 0 0 0 0 0 0 0 0 0 0 0 7.77076 0 9.99605 A0A8I3RRF9 A0A8I3RRF9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LTDGTTDENPGGEG 1 4.5 0.98388 -0.24769 9.01204 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRG5 A0A8I3RRG5_CANLF GATA zinc finger domain containing 2B GATAD2B Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122] "chromosome, telomeric region [GO:0000781]; NuRD complex [GO:0016581]" sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] AVCARWPPRDA;LLPPYPCRGCNVV;RLVLLKKLRQS;SSSRMEERLKAANLE 4 7.5 0.98686 -0.3578 0 0 0 0 4.7844 0 0 0 0 0 0 6.34667 0 8.77093 0 A0A8I3RRG8 A0A8I3RRG8_CANLF Zinc finger CCCH-type containing 18 ZC3H18 Canis lupus familiaris (Dog) (Canis familiaris) ANPWGGPVVDEILPPPP;EDDEEKGEGAPGE;EEWERERAKRDDKDRQHRDRDREKE;ERERERERENRQRERERERERDRE;VVTALSTPLPPI 5 9.4 0.98983 -0.26594 0 6.91767 0 0 0 0 11.8343 5.61259 0 0 0 0 7.13812 0 0 A0A8I3RRG9 A0A8I3RRG9_CANLF HCLS1 associated protein X-1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066] SEGWTETTVTHQEAD 1 9.9 0.98496 -0.24657 0 0 0 0 0 0 0 9.66871 0 0 0 0 0 0 0 A0A8I3RRI6 A0A8I3RRI6_CANLF Uncharacterized protein CASTOR2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TORC1 signaling [GO:1904262] cytosol [GO:0005829] IVDEEGFLELPSSEHLSVADATWL;SLVMDVQTQQRFPSNLLFTS;YISTFKFD 3 15.8 0.98771 -0.48536 0 0 0 0 0 9.65118 0 8.14451 0 0 0 0 0 12.1774 0 A0A8I3RRI9 A0A8I3RRI9_CANLF "RAB39A, member RAS onco family" RAB39A Canis lupus familiaris (Dog) (Canis familiaris) phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482] Golgi apparatus [GO:0005794]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GQERFRSITRSYYRNSVGGFLVFD 1 11.1 0.97136 0.041303 0 0 0 0 0 0 0 0 8.13689 0 0 0 0 0 0 A0A8I3RRJ5 A0A8I3RRJ5_CANLF Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit PPP2R5E Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase activator activity [GO:0072542] ELKRGCFCLLWTWQ;LVKVLIPLHTVRSLS;RQREKKKEKEREELWKKLEDLELKR;RSTLNELVDYITISRGCLTEQ;TLNELVDYI 5 15.2 0.99825 -0.60337 0 0 0 6.49536 0 8.09048 9.66809 0 0 0 0 0 7.77624 10.5837 0 A0A8I3RRK1 A0A8I3RRK1_CANLF 17beta-estradiol 17-dehydrogenase (EC 1.1.1.62) HSD17B3 Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" GVALFPWPLYSMYSASKAFVC 1 8.2 0.98159 -0.2488 0 10.019 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRK3 A0A8I3RRK3_CANLF Proton-activated chloride channel (Transmembrane protein 206) PACC1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] LDQVVENS;LSVKWMIKIRKRY;VVFEWKDPF 3 8.6 0.095238 0.87973 0 3.32912 0 9.39616 9.62427 11.6871 0 0 0 0 9.12469 0 0 8.81282 0 A0A8I3RRK9 A0A8I3RRK9_CANLF Rho guanine nucleotide exchange factor 1 ARHGEF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] EFCHLRLL;EVHSLFLDRLMK;LDELIEVHSL;STEDLQNIFPS 4 4.1 1.0037 -1.1044 0 5.36138 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRL5 A0A8I3RRL5_CANLF DENN domain containing 2D DENND2D Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] guanyl-nucleotide exchange factor activity [GO:0005085] CIGCFGLFSKIL;GAAPSRTRVS;GVQMRFQQ;TFSFVLTNVDG;VGLRAVVHKVVVLL 5 8.6 0.93416 0.060769 0 0 0 4.87627 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRM4 A0A8I3RRM4_CANLF Spire type actin nucleation factor 2 SPIRE2 Canis lupus familiaris (Dog) (Canis familiaris) actin nucleation [GO:0045010]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] actin binding [GO:0003779] CEDSSCGAADEG;DLMANNDCEDSSCGAADE;PSQRRDAFQSLQ;VLSPASSEAQMVQSLGFAIYRA 4 7.4 0.98702 -0.38189 0 0 0 0 4.50919 11.97 0 0 0 0 0 0 3.38805 0 9.14929 A0A8I3RRM6 A0A8I3RRM6_CANLF SRY-box transcription factor 30 SOX30 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EPASNGLVHGSKEV;KKGRLEAEAVTRDAPKGGE;NTITHPVGDAPPAIQLPTPAVQ;YPDERTHSEDS 4 8.5 0.98554 -0.44131 8.29733 0 0 8.96275 0 0 12.193 8.86412 0 0 0 0 0 0 0 A0A8I3RRM8 A0A8I3RRM8_CANLF Peptidylglycine alpha-amidating monooxygenase PAM Canis lupus familiaris (Dog) (Canis familiaris) peptide metabolic process [GO:0006518] transport vesicle membrane [GO:0030658] "copper ion binding [GO:0005507]; L-ascorbic acid binding [GO:0031418]; lyase activity [GO:0016829]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]" DDGSESEEEYSAPLPAAS;DPNSKGGP;EGRTEATHIGGTSSDEMC;GVPIVLITTLLVIPVVVLLAI;GVPIVLITTLLVIPVVVLLAIA;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLGL;MGRPPRPLLLLLLLLLLLGLA;PLLLLLLLLL;PLLLLLLLLLLLGLARAL;PPRPLLLLLLLLLLLGLARALGFRG;PRPLLLLLLLLLLLGLAR;PSSTGSYWFCDEGTCTDKANI;RPLLLLLLLLLL;RPLLLLLLLLLLLGLAR;RPLLLLLLLLLLLGLARALG;RPLLLLLLLLLLLGLARALGFRGP;RPPRPLLLLLLLLLLLGLARAL;RPPRPLLLLLLLLLLLGLARALG;SSTGSYWFCDEGTCTDK;VLQVHYGDISAFRDN;VPIVLITTLLVIPVVVLLAI;VPIVLITTLLVIPVVVLLAIALYI 26 13.9 0.56345 0.40802 0 3.21366 3.38336 0 0 9.27589 2.9583 8.38647 2.61157 0 5.90571 0 0 8.09761 0 A0A8I3RRM9 A0A8I3RRM9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DQKYPDELQE;LVSIPCTSSRRR 2 26.2 0.99399 -0.073741 0 0 9.73667 0 11.5515 0 0 12.1778 0 0 0 0 0 0 0 A0A8I3RRP1 A0A8I3RRP1_CANLF Centrin 1 CETN1 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; centrosome [GO:0005813]; spindle pole [GO:0000922] calcium ion binding [GO:0005509] EAFDLFDADGSGTI;IDEADRDGDGEVNEEEFL 2 18.6 0.99173 -0.27052 6.66491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRP6 A0A8I3RRP6_CANLF CCR4-NOT transcription complex subunit 1 CNOT1 Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" CCR4-NOT core complex [GO:0030015]; nucleus [GO:0005634]; P-body [GO:0000932] molecular adaptor activity [GO:0060090] AALGLLQKAVEGL;AGSVSQELSETILTM;NKQITRLPQLMEVVRSNYEAMIDR;VGTQAIAHIHNKGS;VQELVHPVVDRSIKIA 5 3.6 0.97349 0.041303 0 0 0 0 0 0 0 0 8.1102 0 0 0 0 0 0 A0A8I3RRP8 A0A8I3RRP8_CANLF EPS8 like 1 EPS8L1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ruffle assembly [GO:1900029]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587] actin binding [GO:0003779]; guanyl-nucleotide exchange factor activity [GO:0005085]; T cell receptor binding [GO:0042608] ASPDLGPRGPD;IVDTSGGPRFASDVQ;KVEGDLETE;RLPPNQVPSQSMHLV;RVSPDHVT 5 8.1 0.99818 -0.60693 0 11.3046 11.4933 0 0 0 0 0 0 0 0 0 0 12.318 0 A0A8I3RRQ4 A0A8I3RRQ4_CANLF Immunoglobulin like domain containing receptor 2 ILDR2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; homeostasis of number of cells within a tissue [GO:0048873]; insulin secretion [GO:0030073]; negative regulation of T cell activation [GO:0050868]; pancreas development [GO:0031016]; regulation of RNA splicing [GO:0043484]; response to glucose [GO:0009749] bicellular tight junction [GO:0005923]; membrane [GO:0016020] AFRKGYRIQADKERDSM;CPCCPDSCCCPQAF;CPDSCCCPQ;CQCCPHSCCCYIRCPCCPDS;CQCCPHSCCCYIRCPCCPDSC;DDDDDDDDSAD;DDDDDDDSAD;DDDDDDDSADD;FRKGYRIQADK;GGGGGGGG;LFFVLVGICWCQCCPHSCCCYI;PDSCCCPQAFR;PQDDDDDDDDDS;QDDDDDDDDD;VGGGGGGG;VGGGGGGGG;VGICWCQCCPHSCCCYIRCPCCPD 17 11 1.003 -1.5918 0 7.54241 6.31475 0 6.43676 7.68601 0 4.60478 3.01826 0 5.04019 0 9.14832 8.64861 0 A0A8I3RRQ7 A0A8I3RRQ7_CANLF T-box transcription factor TBX6 TBX6 Canis lupus familiaris (Dog) (Canis familiaris) mesodermal cell fate specification [GO:0007501]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; somite rostral/caudal axis specification [GO:0032525] chromatin [GO:0000785]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] ARYLFLLDVVPVDGARYRWQ;EQPPAPRE;PIAAEAYG 3 8.3 1.0025 -0.77426 12.0658 11.6524 0 0 0 0 11.9758 12.057 11.9598 0 0 0 11.3269 11.4392 0 A0A8I3RRR2 A0A8I3RRR2_CANLF V-type proton ATPase proteolipid subunit ATP6V0C Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Wnt signaling pathway [GO:0030177] "clathrin-coated vesicle membrane [GO:0030665]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; synaptic vesicle membrane [GO:0030672]; vacuolar membrane [GO:0005774]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ubiquitin protein ligase binding [GO:0031625]" VRGTAQQPRLFV 1 7.7 0.99059 -0.26683 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.31061 A0A8I3RRR3 A0A8I3RRR3_CANLF Unc-45 myosin chaperone A UNC45A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; muscle organ development [GO:0007517] perinuclear region of cytoplasm [GO:0048471] ALVNCTNSYDYEEPDPKMVE;DKAETEASKAIE;DTGTRRWAVEG;LCNDQIDTGTRRWAVE;LLHLNCSGLQNFEALMALTNL;LVNCTNSYDYEE;PEQHPKDKPG;VEGLAYLTFD;VPMIEGYMFEEHEMIRRAATECM 9 11.6 1.001 -0.62994 0 8.91088 6.57853 0 7.80665 0 8.49265 8.96287 12.6529 9.31402 7.79889 14.7278 0 0 0 A0A8I3RRR4 A0A8I3RRR4_CANLF Solute carrier family 25 member 46 SLC25A46 Canis lupus familiaris (Dog) (Canis familiaris) cristae formation [GO:0042407]; mitochondrial membrane fission [GO:0090149]; phospholipid homeostasis [GO:0055091]; respiratory chain complex IV assembly [GO:0008535] mitochondrial outer membrane [GO:0005741] protein-containing complex binding [GO:0044877] AASLCSDVILYPLE;CHPPLPSSSIPSPV;HYHLTPFT;LHGVLHYIIS;LILKRKTY;VSHPLLFPPP 6 10.6 0.9922 -0.5413 0 8.92184 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RRS2 A0A8I3RRS2_CANLF "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1)" PLOD1 Canis lupus familiaris (Dog) (Canis familiaris) epidermis development [GO:0008544]; response to hypoxia [GO:0001666] catalytic complex [GO:1902494]; rough endoplasmic reticulum membrane [GO:0030867] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475] EGRRDPAPGA;GAGGGGGG;GGGGGGGA;GGGGGGGG;ITLDHRCRIFQN;LDEVVLKFEMGHVRA;PGAAPAPGEPAGKAF;PLLLLAPLGWLL;PTKLQLNYL;VEQFLAEHGSEYQSVKLVGPEV 10 11.3 1.0027 -0.84508 0 11.5505 0 0 12.3581 0 0 11.0606 12.4003 0 0 5.1903 0 5.67522 9.62148 A0A8I3RRT0 A0A8I3RRT0_CANLF Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) PIK3C3 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; endocytosis [GO:0006897]; phosphatidylinositol-mediated signaling [GO:0048015] "endosome [GO:0005768]; peroxisome [GO:0005777]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]" 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524] FLISRACKNSTLANYLYWYYVIVEC;VELIPLPL 2 3.7 0.97694 0.035538 0 0 0 0 0 0 12.5035 0 0 0 0 0 0 0 0 A0A8I3RRU5 A0A8I3RRU5_CANLF Zinc finger homeobox 2 ZFHX2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]" ALAQAPLGSLAPFSSGP;APPPAVAEEEEGGVG;HYKYQQTLDVHMREKHPE;KTELAEQEWER;LCPPLNQSSPASKEG;LLKLQQQQLLLPFYLH;LPEQLEILYRWYMQDSNPTR;MAPPPAVAEEEEGGVG;MQSDKHLANLQGFQA;PEALGGGD;PLGAQRTDCPYC;PPPPTPPP;PTGGGNGG;QEQLVGRPALHF;SAGGAHPRLARGESYN;SRVVVVWFQNARQKARK;TVFCCPYCSFLSPEPDQ;VGLKKRVVQVWFQNT;VGTEKKGP;YHCSMGRSLPEAEW 20 10.4 0.99676 -4.2099 0 9.46805 8.38245 4.7812 0 0 10.4437 7.43488 10.7262 7.17113 10.4252 6.28125 8.22125 0 11.1703 A0A8I3RRV5 A0A8I3RRV5_CANLF Sushi domain containing 6 SUSD6 Canis lupus familiaris (Dog) (Canis familiaris) ALILLLVVLFVLLQP;ASSVALILLLVVLFVLLQ;TSEDYTDD 3 8.9 1.0022 -1.0022 0 0 0 0 0 0 0 0 3.26203 0 0 0 0 4.81645 3.14683 A0A8I3RRW7 A0A8I3RRW7_CANLF IK cytokine IK Canis lupus familiaris (Dog) (Canis familiaris) "mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]" mitotic spindle pole [GO:0097431]; nuclear chromosome [GO:0000228]; nuclear speck [GO:0016607]; U2-type precatalytic spliceosome [GO:0071005] identical protein binding [GO:0042802] ERERDRERDRERERDRDREREREEE;FSNPLAPDGHDVDDPHS;GVNKDYEETELIST;ISAIIEKRKK;RHHEMPREYNEDED 5 14.6 0.99382 -0.11879 0 0 0 0 0 6.03115 6.92172 7.33056 0 0 8.34487 0 0 0 0 A0A8I3RRX2 A0A8I3RRX2_CANLF WD repeat-containing protein 55 WDR55 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ACEERPAEDGSDEEDP;VACGSSEGTIYL 2 7.3 0.93465 0.099673 0 0 0 0 0 0 0 5.55775 0 9.42618 0 0 0 0 0 A0A8I3RRZ2 A0A8I3RRZ2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of immune system process [GO:0002682]; signal transduction [GO:0007165] cell surface [GO:0009986]; plasma membrane [GO:0005886] protein tyrosine kinase binding [GO:1990782] CLPFREEPRS;DPFTLNVLSEL;NITTTVKAIT 3 13.5 1.0027 -0.75893 10.501 0 0 0 0 8.6252 0 0 0 0 0 0 0 0 0 A0A8I3RRZ6 A0A8I3RRZ6_CANLF MAM domain containing glycosylphosphatidylinositol anchor 2 MDGA2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EERYSERVYTIRE;REALVQLIVQYPPA;VDGAVGILVHL;VGNPAKKST 4 5.3 1.0035 -1.601 0 7.88935 10.5014 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RS04 A0A8I3RS04_CANLF Enolase superfamily member 1 ENOSF1 Canis lupus familiaris (Dog) (Canis familiaris) amino acid catabolic process [GO:0009063] hydro-lyase activity [GO:0016836] DHLHEHFRYPVIIKK 1 4.2 0.95097 0.053874 0 0 0 0 0 0 0 0 0 0 5.01979 0 0 0 0 A0A8I3RS06 A0A8I3RS06_CANLF Tubulin tyrosine ligase like 7 TTLL7 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; protein modification process [GO:0036211] cilium [GO:0005929] tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740] ELQNYQRINHFPG;HVLHAYRMCRPGQP;MKRKVRKKKKKGTI;STQFFMRTPTYTLK 4 6.6 0.9863 -0.45143 0 5.78505 0 0 8.59223 8.49733 0 0 0 0 0 0 0 0 0 A0A8I3RS16 A0A8I3RS16_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) YSLSLSFHSQA 1 6.5 0.95088 0.056521 9.98513 10.3848 10.1403 0 0 0 10.0135 10.0661 0 0 9.02059 0 10.1883 10.128 10.0067 A0A8I3RS22 A0A8I3RS22_CANLF DNA replication complex GINS protein PSF3 GINS3 Canis lupus familiaris (Dog) (Canis familiaris) DNA unwinding involved in DNA replication [GO:0006268] CMG complex [GO:0071162]; GINS complex [GO:0000811] FDNKRRII 1 3.7 0.98981 -0.26592 10.0142 9.46177 0 0 0 8.6252 0 3.60656 0 10.7598 0 0 10.724 10.882 10.838 A0A8I3RS28 A0A8I3RS28_CANLF Clusterin associated protein 1 CLUAP1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995] DLLNNVASDEAN;DSEIDMEGDEEDDDLEDESV;SVLYNAMK;VGTMQGGDSDDDEDSE;VGTMQGGDSDDDEDSEDSE 5 12.1 0.98773 -0.37301 5.66539 8.2673 0 0 0 3.77768 0 0 11.3555 0 0 0 10.4823 0 0 A0A8I3RS33 A0A8I3RS33_CANLF Fibronectin type III domain containing 9 FNDC9 Canis lupus familiaris (Dog) (Canis familiaris) EAEGEADQDDAADEDAANQ;PNWNSIFSGYLRY;PNWNSIFSGYLRYSFHHEEKVPR 3 17.7 0.99227 -0.1661 0 0 0 4.26814 0 0 0 10.1005 0 3.69131 0 0 0 9.46561 0 A0A8I3RS41 A0A8I3RS41_CANLF Uncharacterized protein METTL9 Canis lupus familiaris (Dog) (Canis familiaris) protein-L-histidine N-pros-methyltransferase activity [GO:0106370] VENVGGKWEKPSE 1 4.1 0.98483 -0.2577 0 0 8.42681 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RS47 A0A8I3RS47_CANLF Transcription elongation factor SPT5 SUPT5H Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation-coupled chromatin remodeling [GO:0140673] DSIF complex [GO:0032044]; organelle membrane [GO:0031090] mRNA binding [GO:0003729] AGSEKEEEPE;DEYEDEDQWEDGAEDILEKASNI;EEEEEEEEEEYDEEEEEEDD;EEEEEEEEEEYDEEEEEEDDD;EEEEEEEEEYDEEEEEEDD;EEEEEEEYDEEEEEEDDD;EEEEEYDEEEEEEDD;EEPEEEEEEEEEEEY;EEYDEEEEEEDDDRP;EPEEEEEEEEEEEYDEEEEEEDD;EYEDEDQWEDGAEDIL;FAVALDSEQN;KEEEPEEEEEEEEEEEYDEEEEEE;KRKKFKRPPQRLF;MSDSEDSNFSEEEDSE;PEEEEEEEEEEEYDEEEEE;PEEEEEEEEEEEYDEEEEEE;PMSPRISSPMHPSA;TMHELKVLPRDL 19 11.2 0.99329 -0.04536 0 0 0 7.65835 5.95942 0 7.42492 7.43763 11.2966 4.45246 5.69638 4.04177 14.0458 3.31441 8.72625 A0A8I3RS54 A0A8I3RS54_CANLF RNA binding motif protein 7 RBM7 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] RNA binding [GO:0003723] AEADRTLFVGNLETK;HYSREQRYSDHGSDHHYR;RYSDHGSDHHYRGSRDDYFYEDRNP;YRGSRDDYFYEDRNPEGWSHDYDNR 4 21.4 0.86007 0.17328 7.80193 0 7.20614 0 0 0 0 0 0 0 4.47748 0 8.62797 0 0 A0A8I3RS64 A0A8I3RS64_CANLF Serpin B5 SERPINB5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] NENTSDFSGMSETKGVALS 1 5.1 0.95208 0.049872 0 0 7.17473 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RS77 A0A8I3RS77_CANLF Spectrin beta chain SPTB Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693]; modification of postsynaptic actin cytoskeleton [GO:0098885] cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731] actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200] AEGKQLMEEKAQYAARVSQ;DETLWVEERL;DNLELQNFLQNCQELTLWINDK;EQEVTAAWQAL;ERQWPQDLQ;GDYQQVKASGENV;IETEKMIEKYSG;LDACAGRRTQLVDTA;LDLLEPLERRKKQL;LEDLEVAQHRFDI;LEVLLFTI;QRELALRHELIRQE;TEILGLIDEKHRELPEE;VLSPVDSGNKLVADE 14 8.3 1.0021 -1.308 9.70727 13.6319 10.1524 0 0 0 14.143 9.28198 7.97774 7.011 0 0 10.7366 0 0 A0A8I3RS79 A0A8I3RS79_CANLF U6 snRNA phosphodiesterase (EC 3.1.4.-) USB1 Canis lupus familiaris (Dog) (Canis familiaris) U6 snRNA 3'-end processing [GO:0034477] nucleus [GO:0005634] "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends [GO:1990838]" PLVGYSSS 1 3.2 0.99009 -0.20517 0 0 9.2042 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RS82 A0A8I3RS82_CANLF Basic leucine zipper nuclear factor 1 BLZF1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001] intracellular membrane-bounded organelle [GO:0043231] NITFNCCNHCQGE 1 3.2 0.93721 0.059566 9.04543 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RS85 A0A8I3RS85_CANLF Transmembrane channel-like protein TMC3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] EMYHPRTTLRFQLAR;ETYVGQEMLK;EVVEWSFHPQ;QDQCWETYVGQE;VVDRSQKLEQSKKELTLWEKNEQV 5 5.8 1.003 -0.83793 0 0 0 0 0 0 0 0 0 0 0 5.06156 0 0 0 A0A8I3RS90 A0A8I3RS90_CANLF WAP four-disulfide core domain 1 WFDC1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] KQRRQAELPIV;LNMWEEMP;VAEGIPNRGQCVKQ;VTGPPQPE 4 15.4 1.0023 -1.1875 0 0 0 0 0 11.9583 0 9.13786 0 0 0 0 0 0 0 A0A8I3RS96 A0A8I3RS96_CANLF Dermatopontin DPT Canis lupus familiaris (Dog) (Canis familiaris) collagen fibril organization [GO:0030199]; negative regulation of cell population proliferation [GO:0008285] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] MISYNYDYYMRG;YSCWLTTEYPGHY 2 12.4 0.91683 0.11003 0 0 0 0 0 0 2.96767 0 0 0 0 0 12.7034 0 0 A0A8I3RSA1 A0A8I3RSA1_CANLF Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) LOC479795 EIF3C EIF3S8 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732] "eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]" RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369] CVYLVSAMLLEIPYM;EDDEEDSEDSEDDEDWDTG;HITNYKQNPEQ;KKMEDDEEDSEDSEDDED;LADLEDYLNELWE;MEDDEEDSEDSEDDED;MEDDEEDSEDSEDDEDWD;MIINEELMASL;NLATYMKPEMWQK;PPAAVSDS;VEHLKDEAQVCAIIER;VFDHKQGT 12 12.2 1.0028 -2.5547 11.2102 0 0 5.75478 10.0055 7.18061 7.60748 0 0 0 0 16.0395 10.0027 10.105 10.1224 A0A8I3RSA4 A0A8I3RSA4_CANLF Adenosine deaminase domain containing 2 ADAD2 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] IPNTCHSLSLNWS;IPNTCHSLSLNWSLG;LADPCHDP;VLAPQPGPGPPFAL;VSVPPAGL 5 7.6 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 12.6792 0 0 0 A0A8I3RSA8 A0A8I3RSA8_CANLF Uncharacterized protein TSEN15 Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" nucleus [GO:0005634] nucleic acid binding [GO:0003676] GGGGGGGA;GGGGGGGG;NRSGPQKEDLH;PGGGGGGG 4 16.7 0.98536 -0.23727 0 0 0 0 0 0 0 0 0 0 10.5052 0 0 0 0 A0A8I3RSB1 A0A8I3RSB1_CANLF Phosphorylase b kinase regulatory subunit PHKB Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] plasma membrane [GO:0005886] calmodulin binding [GO:0005516] DLEQQPDVAIAEWKHKPT;FLRSGSTFYLLYV;IVVELLMVVSIVLERNPEL;LSDMTMYEMNFSLL;LSLGATVPG 5 6.4 0.98715 -0.32717 8.69825 0 0 0 0 0 0 11.629 0 0 0 9.30449 5.19594 0 0 A0A8I3RSC1 A0A8I3RSC1_CANLF Integrin alpha FG-GAP repeat containing 1 ITFG1 Canis lupus familiaris (Dog) (Canis familiaris) AGQLSQSAHLA;LLGVGPVP;RVYWELMDLNQIRDAMVATFFDI 3 7 1.0028 -1.1979 0 8.89197 0 12.3766 0 0 0 9.78857 0 0 0 0 0 0 0 A0A8I3RSC2 A0A8I3RSC2_CANLF Cadherin domain-containing protein LOC119863934 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;LEVNLQNGILFV;LVTVLDVNDNAPSFEQTEYEVRIF;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK 9 13.6 0.99395 -0.2851 0 0 0 0 0 0 0 0 11.6988 0 0 0 0 0 0 A0A8I3RSD1 A0A8I3RSD1_CANLF AMP deaminase (EC 3.5.4.6) AMPD2 Canis lupus familiaris (Dog) (Canis familiaris) IMP salvage [GO:0032264] AMP deaminase activity [GO:0003876]; metal ion binding [GO:0046872] EEYSIATQVWKLSSCDMCE;IFLPLFEATVHPA;RVPPPSPRR 3 5.1 0.99046 -0.26866 0 0 0 0 0 0 0 0 0 10.7598 10.5453 0 0 0 0 A0A8I3RSF9 A0A8I3RSF9_CANLF IQ motif containing C IQCC Canis lupus familiaris (Dog) (Canis familiaris) CERAGSQTSPPPKN;NSKGGSSRASSLERSETV 2 5.2 0.98943 -0.53118 0 0 0 0 0 0 0 10.9789 0 0 0 0 0 0 0 A0A8I3RSG1 A0A8I3RSG1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RCPLRQAKA 1 7.7 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 4.91476 0 0 0 0 0 A0A8I3RSG8 A0A8I3RSG8_CANLF "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)" L2HGDH Canis lupus familiaris (Dog) (Canis familiaris) small molecule metabolic process [GO:0044281] membrane [GO:0016020]; mitochondrion [GO:0005739] 2-hydroxyglutarate dehydrogenase activity [GO:0047545] GNIYPVPDSRFP;PDSRFPFLGVHFT 2 4.1 0.98994 -0.26396 0 0 0 5.52863 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSH2 A0A8I3RSH2_CANLF Uncharacterized protein CASP16 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] TVAVLEAVFRTLGFECCQRTEA 1 4.8 0.97761 0.04742 0 0 0 0 7.93958 0 0 0 0 0 0 0 0 0 0 A0A8I3RSH5 A0A8I3RSH5_CANLF Cadherin domain-containing protein LOC106557821 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DIQLVKYLNYEV;GVWAHNGEVRTARL;IDVNDHSPVFL;SPETVVAVFSVSDP 4 6.5 0.10714 0.83931 10.5456 12.2863 12.401 0 0 0 10.9233 0 10.429 10.1311 9.97298 0 9.86494 9.83864 0 A0A8I3RSH8 A0A8I3RSH8_CANLF Adrenal ferredoxin (Ferredoxin-1) FDX1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; steroid biosynthetic process [GO:0006694] mitochondrial matrix [GO:0005759] "2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]" EQLSDLLLSCS;VCLTKAMDNMTVRVPDVVAD 2 17.3 0.99035 -0.51595 9.77551 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSI9 A0A8I3RSI9_CANLF Synaptophysin like 2 SYPL2 Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507]; intracellular calcium ion homeostasis [GO:0006874]; T-tubule organization [GO:0033292] membrane [GO:0016020]; synaptic vesicle [GO:0008021] VLQWLFAIFAF 1 4.1 0.9907 -0.21542 0 0 0 0 0 0 0 0 0 0 0 0 0 13.0341 0 A0A8I3RSJ0 A0A8I3RSJ0_CANLF Conserved oligomeric Golgi complex subunit 4 (Component of oligomeric Golgi complex 4) COG4 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] Golgi apparatus [GO:0005794]; membrane [GO:0016020] AENVSSKVRQL;DLAAVSNKFRDL;FSEYLCKQ;LQQGKFDTKGIESTDEAKLSFL;STELIRSL;STELIRSLTELQE 6 8.6 1.0032 -2.0975 0 6.17983 8.44079 0 0 0 0 9.40248 0 0 0 0 8.0284 0 11.6031 A0A8I3RSJ3 A0A8I3RSJ3_CANLF Uncharacterized protein UCN3 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755] extracellular space [GO:0005615] corticotropin-releasing hormone receptor 2 binding [GO:0051431]; hormone activity [GO:0005179] LLLLLLLL;LLLLLLLLP;LLLLLLLLPGI;LLLLLLLLPGIPQ;LLLLLLLP;LQAKAAANAHL 6 14.4 0.99531 -0.15333 0 5.23622 0 0 0 3.334 0 5.96765 0 0 0 10.0181 0 0 0 A0A8I3RSK2 A0A8I3RSK2_CANLF Spermidine synthase SRM Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; spermidine biosynthetic process [GO:0008295] protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766] GVIQCTERDEFSYQE;LFKESYYQ 2 7.6 0.99409 -0.15583 0 0 0 0 0 0 0 0 0 11.3335 0 0 0 0 6.2058 A0A8I3RSK9 A0A8I3RSK9_CANLF G protein-coupled receptor 137B GPR137B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506] lysosomal membrane [GO:0005765] IVPSHGFSPRSYFFDNPRRY;LSPFVFWLLYC;TVFYSLLFAFIY;YFTQVIFKAKSKY 4 14.1 0.99704 -0.088195 7.17812 0 0 0 9.62507 0 9.92631 0 10.0547 0 0 0 0 0 0 A0A8I3RSL4 A0A8I3RSL4_CANLF Galactosidase beta 1 like 2 LOC607396 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" DDIYIGILDHST 1 3.1 0.94632 0.05044 0 10.1992 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSM6 A0A8I3RSM6_CANLF Actin maturation protease (Actin aminopeptidase ACTMAP) ACTMAP Canis lupus familiaris (Dog) (Canis familiaris) protein processing [GO:0016485] cysteine-type aminopeptidase activity [GO:0070005]; initiator methionyl aminopeptidase activity [GO:0004239] EDPELPGL;VKRLLKLHKDRFRSD 2 6.8 0.99204 -0.20686 0 0 0 0 0 0 4.4363 0 11.1063 0 0 0 0 0 0 A0A8I3RSP2 A0A8I3RSP2_CANLF "Dynein heavy chain, cytosolic" DYNC1H1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of spindle localization [GO:0051293]; microtubule-based movement [GO:0007018]; P-body assembly [GO:0033962]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic spindle organization [GO:0060236]; stress granule assembly [GO:0034063] centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; filopodium [GO:0030175]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AANDKLKKMVKD;AEPLTAAMVEF;AIGSAEGFNQADKAIN;AIHRLLLIQAFRPDRLLAMAHMFVS;DEGEIAENLPEQ;DTVDTWLDDTAKG;EAIVNSCVFVHQTLHQ;ERERWEKTSETFKN;ETRITARLRDQ;GLRAWTQVLL;HYCEYRRTPNGV;NAIEEVNLAY;NLHSYSNL;PIHPIITNV;PLDLTHIVDTEV;PLRRRKLEHLITELV;RWTDENIDMVALKHFPNI;STSDGRPAWMRT;TFAMLLARIK;TQINHGLMMVGPSGSGKSMAWRVL;VLCGPPGSGKTMTLF;VLQKHLRKLVP;VLSNVEVTLNVLADSVLMEQP;VVYVDYPGPAS;YITWIDKYQAQL 25 7.3 0.9988 -3.2671 9.47334 8.41773 11.9087 0 9.4952 4.8801 11.9116 11.7766 9.74003 9.32497 8.28388 10.8517 10.4339 10.8488 8.75866 A0A8I3RSP9 A0A8I3RSP9_CANLF RNA polymerase II subunit C POLR2C Canis lupus familiaris (Dog) (Canis familiaris) "RNA polymerase II, core complex [GO:0005665]" DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055] PDNALRHTVYPKPEE;PKSEYSELDEDESQAPYDP 2 12.4 0.93626 0.10335 0 0 0 0 0 0 0 0 0 0 6.73417 0 7.2651 0 0 A0A8I3RSS6 A0A8I3RSS6_CANLF Cilia- and flagella-associated protein 206 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288] axoneme [GO:0005930]; ciliary basal body [GO:0036064] ATPPHVGSAHKAPWVG 1 7 0.95598 0.049233 0 0 8.71692 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSS7 A0A8I3RSS7_CANLF Malic enzyme ME2 Canis lupus familiaris (Dog) (Canis familiaris) "malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" DEFMKAITDRYGQNT;FMKAITDRYGQN;GLYQKRDRSQRYDDLIDEFMKA;YTPTVGLACSQYGHIFRRP 4 10.4 0.99134 0.0010834 9.39468 0 8.0143 0 0 0 0 0 0 0 0 10.5669 0 0 0 A0A8I3RST6 A0A8I3RST6_CANLF Transmembrane protein 229B TMEM229B Canis lupus familiaris (Dog) (Canis familiaris) macrophage activation [GO:0042116]; response to bacterium [GO:0009617] membrane [GO:0016020] AAWEFVVNFNWKFPGVTSVWA;CPWDYSQFDFDFMG 2 20.8 0.92283 0.11577 0 0 0 2.45289 0 0 0 0 0 0 0 0 0 10.8816 0 A0A8I3RST8 A0A8I3RST8_CANLF MOK protein kinase MOK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] PDERITAHQALQHPYFHEQR 1 5.2 0.95006 0.049989 9.24757 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSU1 A0A8I3RSU1_CANLF Gem-associated protein 2 GEMIN2 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] SMN complex [GO:0032797]; spliceosomal complex [GO:0005681] GLKTMAWM 1 3.2 1.0048 -1.1044 0 5.18229 0 0 9.10612 0 0 0 0 0 0 11.0912 0 4.25807 0 A0A8I3RSU3 A0A8I3RSU3_CANLF Cytoplasmic tRNA 2-thiolation protein 2 CTU2 NCS2 Canis lupus familiaris (Dog) (Canis familiaris) protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737] nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] DSCTRLAIKLMT 1 2.4 0.98483 -0.2577 0 0 0 0 0 0 0 0 0 0 10.4487 0 0 0 0 A0A8I3RSV4 A0A8I3RSV4_CANLF TBC1 domain family member 19 TBC1D19 Canis lupus familiaris (Dog) (Canis familiaris) AVNLMEVTSLAAAEAVL;GEQKELLNKWNEMGTDEPDLS;ISSHPSGIV;LKVKDIPELKEFFVELGL;VIPFHGFSMYVAPL;VNLMEVTSLAAAEAVLA 6 17.4 0.98509 -0.43823 11.2852 11.8296 10.9524 8.93443 8.98976 8.83254 12.1483 11.6522 11.4688 9.66995 9.19279 9.0571 11.2678 11.2274 0 A0A8I3RSW1 A0A8I3RSW1_CANLF Axonemal dynein light chain domain containing 1 AXDND1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DLVTQRMMDQRIL;DQIARQMIDFYKDLVTQRMMDQRI;EDFVKELIERE;EETRPLEHSQ;LMAERDLWSSA 5 5.6 1.0018 -0.96488 0 0 9.08584 9.51779 9.13632 0 0 0 13.3224 0 0 0 0 0 0 A0A8I3RSW2 A0A8I3RSW2_CANLF Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30 kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit) CPSF4 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654] RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270] TEQPPLPQQTQPATKQS 1 6.3 0.98337 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 8.19923 0 A0A8I3RSW8 A0A8I3RSW8_CANLF Uncharacterized protein VTI1B Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] DVPPPSPESP;LVAGGGGGG;TAPASAGPRSP 3 7.4 1.0031 -0.88693 0 0 0 0 0 0 0 0 0 0 0 8.37764 0 0 0 A0A8I3RSX0 A0A8I3RSX0_CANLF Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) TOMM20 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; tRNA import into mitochondrion [GO:0016031] cell periphery [GO:0071944]; migrasome [GO:0140494]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial outer membrane translocase complex [GO:0005742]; sperm midpiece [GO:0097225] mitochondrion targeting sequence binding [GO:0030943]; protein-transporting ATPase activity [GO:0015450]; unfolded protein binding [GO:0051082] PNFKNRLRERRKKQKLAK 1 12.4 0.97978 0.048313 0 0 0 0 0 0 0 0 0 0 0 4.58862 0 0 0 A0A8I3RSY3 A0A8I3RSY3_CANLF Cholecystokinin receptor type A (Cholecystokinin-1 receptor) CCKAR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] cholecystokinin receptor activity [GO:0004951] NNQTANMCRFLLPN;VIATTWCLSFTIMT 2 7 0.85119 0.15149 0 7.45335 9.05466 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RSZ6 A0A8I3RSZ6_CANLF "Spectrin beta, non-erythrocytic 4" Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693] membrane [GO:0016020]; organelle [GO:0043226] actin binding [GO:0003779]; phospholipid binding [GO:0005543] RPVSPPDR;SNQKFANSLSGVQQQLQ;VGARRTRLEQNLALQK;VLTVSLPT 4 5.8 1.0023 -1.3684 0 0 0 0 0 0 0 7.11207 0 10.0355 0 0 0 0 0 A0A8I3RT14 A0A8I3RT14_CANLF Serine incorporator 5 SERINC5 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; lipid metabolic process [GO:0006629]; myelination [GO:0042552] centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886] AGQLACCCGSAGCSLCCGC;CCAGQLACCCGSAGCSLCCGCC;CCCGSAGCSLCCGCCP;DQETFLNAW;FYEDICKG;LACCCGSAGCSLCCGCC 6 8.7 0.98649 -0.32044 0 3.23718 0 7.89282 0 0 5.88455 6.99356 0 0 8.84552 0 0 5.92412 0 A0A8I3RT23 A0A8I3RT23_CANLF Hook microtubule tethering protein 1 HOOK1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi organization [GO:0007030]; lysosome organization [GO:0007040]; manchette assembly [GO:1905198]; protein localization to perinuclear region of cytoplasm [GO:1905719] FHF complex [GO:0070695]; HOPS complex [GO:0030897]; microtubule [GO:0005874] actin binding [GO:0003779]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803] AWYNKSLAFQK;EILNSPTNDTVGE;FNTAAPCQDVKQLTNGV 3 5.6 0.98751 -0.33848 0 7.13556 0 0 0 0 0 0 0 0 11.878 0 0 0 0 A0A8I3RT25 A0A8I3RT25_CANLF POM121 transmembrane nucleoporin like 12 LOC119876219 Canis lupus familiaris (Dog) (Canis familiaris) AALQRIDRALR;AAPPVPCQMKNQ;ELGFRVTAEDLDGEKKAAL;VGAAPAGL;VPSSPSSGTSAGLAPQPASDGQVTP 5 8.2 1.0024 -1.2009 12.7269 0 8.25408 0 0 8.27547 9.21269 0 0 8.41857 0 0 0 13.2202 0 A0A8I3RT26 A0A8I3RT26_CANLF Periaxin PRX Canis lupus familiaris (Dog) (Canis familiaris) peripheral nervous system myelin maintenance [GO:0032287]; regulation of RNA splicing [GO:0043484] cytoplasm [GO:0005737]; nucleus [GO:0005634] ASFGEAGPG;EFGIKLPKMTM;FTAPQVELVGPRL;KGPVPAAP;RVRLPSVG;RVRVRLPRVGLATP;VSEMRLPEM 7 5.1 0.99942 -2.919 10.5735 0 0 0 0 0 8.17687 0 10.5071 0 9.63154 0 4.88064 0 10.2457 A0A8I3RT29 A0A8I3RT29_CANLF WASH complex subunit 4 WASHC4 Canis lupus familiaris (Dog) (Canis familiaris) endosomal transport [GO:0016197]; endosome organization [GO:0007032] endosome [GO:0005768]; WASH complex [GO:0071203] AKLLDRKSLQAIKIHR;ETLKAARHLDSVLS;IMNTTVNFTYQ;SVSHITQHLQHQ;THYLDKTFYNL;VETLSPDWEFDRVDDG;VFVSSWMMKMESILSKEQKM;VISDKKYSEQR 8 10.4 1.0026 -0.97359 0 0 0 7.97396 0 0 0 0 0 7.92226 0 0 7.1236 0 0 A0A8I3RT30 A0A8I3RT30_CANLF Olfactory receptor OR5M3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILLAILRMHSA;LSFCGNIEINHF 2 7.5 0.99257 -0.55209 0 0 0 0 0 0 0 0 0 0 9.3258 0 0 0 0 A0A8I3RT39 A0A8I3RT39_CANLF Proteasome subunit beta PSMB6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; proteasome core complex [GO:0005839] threonine-type endopeptidase activity [GO:0004298] KEMCYRYREDLMAGIIIAGWDPQEG;YREDLMAGIIIAGWDP 2 10.5 0.98776 -0.46448 0 0 0 0 10.3648 0 0 0 0 0 0 0 0 10.6628 0 A0A8I3RT43 A0A8I3RT43_CANLF Janus kinase and microtubule-interacting protein C-terminal domain-containing protein JAKMIP1 Canis lupus familiaris (Dog) (Canis familiaris) kinase binding [GO:0019900]; microtubule binding [GO:0008017] EFDSQVLRERMELLQ;FRVLELEERERR;HVIDDLSLKHVVE;NELLKRSRETEVQLK 4 8.5 0.93315 0.068155 0 0 0 10.1422 0 13.6328 0 0 0 5.70172 0 0 0 0 0 A0A8I3RT50 A0A8I3RT50_CANLF Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) ACTN1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; focal adhesion assembly [GO:0048041]; muscle cell development [GO:0055001]; platelet formation [GO:0030220] actin filament [GO:0005884]; brush border [GO:0005903]; cortical actin cytoskeleton [GO:0030864]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; nuclear receptor coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; structural constituent of postsynapse [GO:0099186]; transmembrane transporter binding [GO:0044325]; vinculin binding [GO:0017166] CQRKTAPYKN;IDQLEGDHQ;IDQLEGDHQL;IDQLYLEYA;IENIEEDFRDGLK;NLNTAFDVAEKYLDIP 6 6.2 0.92832 0.10641 0 12.0127 0 0 11.5505 11.6288 12.2687 12.5074 0 12.1184 9.80742 12.0247 11.7146 11.6411 0 A0A8I3RT60 A0A8I3RT60_CANLF Ras-related protein Rab RAB38 Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; phagosome-lysosome fusion [GO:0090385] late endosome [GO:0005770]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; trans-Golgi network [GO:0005802] GTP binding [GO:0005525]; GTPase activity [GO:0003924] CAGGGAPA 1 1.9 1.0031 -1.1044 0 0 0 0 9.52605 0 0 0 0 0 0 0 0 0 0 A0A8I3RT79 A0A8I3RT79_CANLF Transcriptional adapter 1 (Transcriptional adapter 1-like protein) TADA1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124] transcription coactivator activity [GO:0003713] DAEQQAAL;VIPTHTVYAL 2 5.4 1.0019 -1.4187 0 0 9.51389 0 0 0 0 0 0 0 0 9.66269 0 0 0 A0A8I3RTA1 A0A8I3RTA1_CANLF Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709] FQMPLESFHSLQEDWKLEI;RAVSRGHRRTPSD;TAKEWGTTP;TPIAPGFA;VLLWELLTGEV 5 6.5 1.0032 -1.1127 0 0 0 0 0 0 0 0 0 0 0 9.46367 0 8.28188 8.82582 A0A8I3RTA5 A0A8I3RTA5_CANLF Cytochrome c oxidase subunit Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] PISWVSAWDDCWAEGTFP 1 22 0.97465 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 5.07378 0 A0A8I3RTB2 A0A8I3RTB2_CANLF Elongation factor 1-gamma (eEF-1B gamma) Canis lupus familiaris (Dog) (Canis familiaris) translation elongation factor activity [GO:0003746] LKQIINKNKRQPTEW;QELAFPLSPD 2 4.9 0.95235 0.053874 7.30278 6.66448 0 0 0 0 0 8.79198 0 0 0 0 0 9.25659 0 A0A8I3RTB7 A0A8I3RTB7_CANLF Protein-arginine deiminase (EC 3.5.3.15) PADI4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668] DDVTCYDQDNCDRH;DLEDMSVMVL;VCRVRNNTCFVDAVAEL;YVCRVRNNTCFVDA 4 6.2 1.0035 -1.1098 0 0 0 0 0 0 6.63636 0 0 9.19783 0 0 0 0 0 A0A8I3RTC6 A0A8I3RTC6_CANLF SEL1L family member 3 SEL1L3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AIEWYAKG;AKRYLGVN;ALIYDYAIVL;ATKTPLDQHTLQGD;IEVSQTNLAH;LGGRPACALLLLCYLNVV;QTKEDGDVFMWLKHE 7 7.5 1.0006 -2.7976 8.72206 0 10.5795 0 0 0 9.1132 0 0 9.2954 0 2.32608 10.169 0 8.92374 A0A8I3RTD2 A0A8I3RTD2_CANLF Translation machinery-associated protein 16 TMA16 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] preribosome binding [GO:1990275] AAQITREVHKQEKKEKLKNEK;LEQIELHNSIKDRQGRRHYSRETVI;VIKQTMERERQQYEGYG 3 30 0.97697 0.047166 0 0 0 0 0 0 0 0 0 0 0 0 6.50928 0 0 A0A8I3RTD6 A0A8I3RTD6_CANLF Solute carrier family 10 member 1 SLC10A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] symporter activity [GO:0015293] DKRNTKEE 1 2 0.98543 -0.25845 0 0 0 0 0 0 9.84762 0 0 0 0 0 0 0 0 A0A8I3RTE8 A0A8I3RTE8_CANLF Arginase (EC 3.5.3.1) ARG1 Canis lupus familiaris (Dog) (Canis familiaris) arginine metabolic process [GO:0006525]; urea cycle [GO:0000050] arginase activity [GO:0004053]; metal ion binding [GO:0046872] HNTRRKRKPRREARV 1 3.4 0.95302 0.053874 0 0 0 0 0 0 7.65019 0 0 0 0 0 0 0 0 A0A8I3RTE9 A0A8I3RTE9_CANLF RAN binding protein 3 like RANBP3L Canis lupus familiaris (Dog) (Canis familiaris) intracellular transport [GO:0046907] CLGATSVG;VERVLDTQN 2 3.6 1.0034 -1.0701 0 0 0 0 0 0 0 9.02741 9.81898 0 0 0 0 0 0 A0A8I3RTF1 A0A8I3RTF1_CANLF TGF-beta family profile domain-containing protein NODAL Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] SSGSMVLEVT;TFAFDFSF 2 5.2 1.003 -1.7158 9.08332 0 0 0 0 0 0 0 8.70867 0 0 0 0 0 0 A0A8I3RTG0 A0A8I3RTG0_CANLF Myosin light chain 6B MYL6 Canis lupus familiaris (Dog) (Canis familiaris) myosin II complex [GO:0016460] calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307] AKNKDQGTYEDYVEGLRVFDKEG;CINYEGEGLGALVEEAVVQAA 2 32.4 0.98596 -0.23232 7.60822 0 0 0 0 0 0 0 0 0 0 0 0 11.3842 0 A0A8I3RTG5 A0A8I3RTG5_CANLF Uncharacterized protein SOWAHC Canis lupus familiaris (Dog) (Canis familiaris) EPAEPAEPAEPAEPAEPE;GAPFTPHHLQTLT 2 6.4 0.99103 -0.27426 0 0 0 0 0 0 0 0 0 0 0 6.47143 0 0 0 A0A8I3RTG6 A0A8I3RTG6_CANLF Nuclear receptor coactivator 5-like LOC487290 Canis lupus familiaris (Dog) (Canis familiaris) EDMLSIKELWR;ERDRERPSDCVIVYINNEQR;PQTTQLDDASI;VIMLHESI 4 12.3 1.0036 -1.6067 0 8.37508 0 0 9.51877 0 0 0 0 0 0 0 5.99288 0 0 A0A8I3RTG8 A0A8I3RTG8_CANLF Transmembrane protein 120A TMEM120A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244] mitochondrion [GO:0005739] protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; pseudophosphatase activity [GO:0001691] GAEAAAESGAGR 1 2 0.99568 -0.092786 0 0 0 0 0 0 11.7797 0 0 0 0 0 0 0 0 A0A8I3RTH0 A0A8I3RTH0_CANLF Olfactory receptor OR10AG63 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVFLIIYVIILMGNSLIII 1 6 0.95292 0.04941 0 0 8.55666 0 0 0 0 0 0 0 0 0 8.05907 0 0 A0A8I3RTI1 A0A8I3RTI1_CANLF Uncharacterized protein TPGS2 Canis lupus familiaris (Dog) (Canis familiaris) LDRALYWHFLTD;RVFKSKNKTLIPKKKGPVQPPG 2 13.7 0.9902 -0.19632 0 0 0 0 0 0 0 0 0 8.46385 0 0 6.27195 0 0 A0A8I3RTJ3 A0A8I3RTJ3_CANLF Glucose-fructose oxidoreductase domain-containing protein 2 GFOD2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] DDFCFFQMLMGGGV;EEAKQLAE;EGFTVEALWGKTEE 3 9.1 1.0022 -0.95577 0 0 0 8.16717 0 0 0 0 13.9626 0 9.7467 0 0 0 0 A0A8I3RTK2 A0A8I3RTK2_CANLF Zinc finger protein 383 ZNF383 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] KPQVISLLEQGKE;PFECKECGKAFSCSSYLSQHQ 2 7.2 0.98955 -0.21266 0 0 9.61563 0 0 0 0 0 5.78694 0 0 0 0 0 0 A0A8I3RTL6 A0A8I3RTL6_CANLF Calcium and integrin-binding family member 2 CIB2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] APPCRKSPPRPAGSP 1 5.1 0.95126 0.053901 0 0 0 0 7.72485 0 0 0 0 0 0 0 0 0 0 A0A8I3RTM0 A0A8I3RTM0_CANLF Centrosomal protein 85 like CEP85L Canis lupus familiaris (Dog) (Canis familiaris) neuron migration [GO:0001764] pericentriolar material [GO:0000242] APWQQQQIEE;EQLRTNPLESRT;IDQLFKEMSYC;LTSQLRTIGP;YLADLPTLDDVQSQSLQ 5 7.4 1.0029 -0.9837 5.4139 0 0 0 0 0 11.3845 6.40271 10.1153 0 0 6.45784 0 0 0 A0A8I3RTM4 A0A8I3RTM4_CANLF NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (NADH-ubiquinone oxidoreductase B17 subunit) Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial respiratory chain complex I [GO:0005747] QELSPWEPVLP;YRHSIFAFTHVLIPAWIVHYYIKYH 2 28.1 0.98438 -0.2551 7.46695 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RTN3 A0A8I3RTN3_CANLF BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BTB/POZ domain-containing protein TNFAIP1) TNFAIP1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; immune response [GO:0006955]; negative regulation of Rho protein signal transduction [GO:0035024]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; stress fiber assembly [GO:0043149] Cul3-RING ubiquitin ligase complex [GO:0031463]; endosome [GO:0005768]; nucleus [GO:0005634] identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin-protein transferase activity [GO:0004842] FCSSTQRHDRK;ISWTLCSPFLTGSCFCPWGKW;KWTDLPTTYENNLLNS;VQLNVGGSLYYTT 4 16.4 0.98781 -0.46923 0 0 10.4341 0 9.08122 0 0 8.29283 0 0 0 0 0 0 0 A0A8I3RTN9 A0A8I3RTN9_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] trace-amine receptor activity [GO:0001594] GVKAKKKKKKKK;GVKAKKKKKKKKK;GVKAKKKKKKKKKK;GVKAKKKKKKKKKKE;KAKKKKKKKKKK;KKKKKKKK;KKKKKKKKKKE;KKKKKKKKKKEETSTIYV;VKAKKKKKK;VKAKKKKKKKK 10 8.6 0.99609 -0.016913 2.42266 5.44371 5.75654 6.29315 0 4.92229 0 0 0 5.53176 7.39369 0 0 0 5.92548 A0A8I3RTP5 A0A8I3RTP5_CANLF T-box transcription factor T (Brachyury protein) (Protein T) TBXT Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AQARLIASWTPVSP;MEEPGDSQQSGYSQSYSDNP;QYDASAQARLIA 3 10.3 0.97307 0.048206 0 0 0 0 0 0 0 0 0 0 0 6.94673 0 0 0 A0A8I3RTQ8 A0A8I3RTQ8_CANLF LYR motif-containing protein 2 LYRM2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrion [GO:0005739] LTLKQFLRRQQVLLLYRRIL;LTLKQFLRRQQVLLLYRRILQAIRQ;LYRRILQAIRQ;VLLLYRRIL 4 28.4 1.0018 -0.68498 6.61102 11.1554 0 0 0 5.50303 0 0 0 0 0 0 0 0 0 A0A8I3RTQ9 A0A8I3RTQ9_CANLF Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) SLC39A6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] metal ion transmembrane transporter activity [GO:0046873] GCKNKCHSHFH;VMIAHAHPQ 2 2.8 1.0035 -1.1058 0 0 0 7.97304 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RTR4 A0A8I3RTR4_CANLF Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 APOBEC4 Canis lupus familiaris (Dog) (Canis familiaris) CIGKMYNFLITYPDVTL;KDLRSPPMGMPVDGV;LDCSNCPY;MSFQETKDLRSPPMGM;THPESMLFEMNGYFDSAVHNNNT;YNFLITYPDVTLSIYFS 6 20.2 1.003 -0.85576 0 0 0 0 5.89954 0 0 10.0914 0 5.80916 10.206 0 0 8.06507 0 A0A8I3RTS2 A0A8I3RTS2_CANLF Collagen beta(1-O)galactosyltransferase 2 COLGALT2 Canis lupus familiaris (Dog) (Canis familiaris) EPLLIYPT;HYVEWRPMDEPESYP;HYVEWRPMDEPESYPDE;QLDWELIYIGRKRMQVK 4 6.7 1.003 -1.5068 10.3793 0 0 0 10.1167 0 0 11.6278 13.5663 0 0 11.6495 0 7.13124 0 A0A8I3RTV1 A0A8I3RTV1_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 19 ADAMTS19 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AEDCEDYS;AEDCEDYSKCYV;EAGVWSEC;GAGGGGGG;GGGGGGGA;GGGGGGGG;IMSGEWIKGQN;IQLNEDFIFIEPLNDTMAI;LTFKCLGDQWPVYCRVIR;MSTSWGEDMTSVDA;PCSRTCGK;RPREAEDCEDY;YVRRGLWEKI 13 9.4 0.99836 -3.2977 11.4886 11.4294 10.7339 7.34917 7.18765 6.6308 0 0 7.73586 0 0 11.3194 0 10.0163 0 A0A8I3RTV2 A0A8I3RTV2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TSSK3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; spermatogenesis [GO:0007283] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FDDTDIPKMLW 1 4.1 0.98521 -0.24689 0 0 0 0 0 0 0 0 10.0771 0 0 0 0 0 0 A0A8I3RTW7 A0A8I3RTW7_CANLF Sphingomyelin phosphodiesterase (EC 3.1.4.12) SMPD1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; cellular response to UV [GO:0034644]; ceramide biosynthetic process [GO:0046513]; cholesterol metabolic process [GO:0008203]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of viral entry into host cell [GO:0046598]; response to interleukin-1 [GO:0070555]; response to ionizing radiation [GO:0010212]; response to tumor necrosis factor [GO:0034612]; response to type I interferon [GO:0034340]; response to virus [GO:0009615]; sphingomyelin catabolic process [GO:0006685]; symbiont entry into host cell [GO:0046718]; termination of signal transduction [GO:0023021] endolysosome [GO:0036019]; extracellular space [GO:0005615]; plasma membrane [GO:0005886] "acid sphingomyelin phosphodiesterase activity [GO:0061750]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; zinc ion binding [GO:0008270]" LLWVGLALALPHALV;MNFCSRENFWLL;SPALCRHLVPDGS 3 6.4 0.99364 -0.074042 0 0 0 0 0 10.7893 8.9479 0 0 0 0 0 0 0 6.54796 A0A8I3RTX9 A0A8I3RTX9_CANLF Importin subunit alpha KPNA6 Canis lupus familiaris (Dog) (Canis familiaris) entry of viral genome into host nucleus through nuclear pore complex via importin [GO:0075506]; maternal process involved in female pregnancy [GO:0060135]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral life cycle [GO:1903902]; transcription by RNA polymerase II [GO:0006366]; viral genome replication [GO:0019079] cytoplasm [GO:0005737]; host cell [GO:0043657]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654] nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139] DLIEHYFGVEDDDSSL;EEAYGLDKIEFLQSHENQEIY;GVVDRFVEFLKRN;LADACWALSYLSDG;VEMLFSDDSDLQLAT 5 14.7 0.9963 -0.11294 0 0 0 0 0 0 0 0 4.84413 7.29352 0 0 11.1624 0 0 A0A8I3RTZ1 A0A8I3RTZ1_CANLF Olfactory receptor OR4P6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HYAILMNRQR 1 3.2 0.99964 -0.61146 0 8.32382 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RTZ3 A0A8I3RTZ3_CANLF Uncharacterized protein ADAM21 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] axon [GO:0030424]; neuronal cell body [GO:0043025] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DLPEWCNGTSHQCP;TLKQNSNDKLWTH 2 3.8 0.8655 0.13576 0 9.42721 0 0 0 0 8.04811 0 0 0 0 0 0 0 0 A0A8I3RTZ6 A0A8I3RTZ6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FGCPFCQKKMSLWSCTCCFF 1 7.3 0.96545 0.048368 5.77729 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RTZ7 A0A8I3RTZ7_CANLF Nuclear apoptosis-inducing factor 1 NAIF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] EQRVTNLHVKEI;TGGGSGSG;VLIQVLRPMIKDFRRYL 3 11.3 0.93188 0.096667 5.38408 0 9.42444 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RU01 A0A8I3RU01_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LVDEAVREQGHAPLVHCDILP 1 9.8 0.94921 0.050031 0 0 0 0 0 0 9.19849 10.5528 0 0 0 0 0 0 0 A0A8I3RU02 A0A8I3RU02_CANLF Transmembrane protein 243 TMEM243 Canis lupus familiaris (Dog) (Canis familiaris) TACILIYWYRQ 1 9.3 0.98854 -0.26069 0 0 0 9.7912 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RU17 A0A8I3RU17_CANLF Protein unc-119 homolog A UNC119 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; protein transport [GO:0015031]; visual perception [GO:0007601] centrosome [GO:0005813]; spindle pole [GO:0000922] lipid binding [GO:0008289] PEPQLQAESESGSESEP 1 7.7 0.97989 0.046227 0 0 0 0 0 0 0 0 0 0 0 6.27737 0 0 0 A0A8I3RU21 A0A8I3RU21_CANLF Olfactory receptor OR4P30 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MKKAMRKVW 1 2.9 0.99207 -0.27195 0 0 0 0 0 0 0 0 12.0963 0 0 0 0 0 0 A0A8I3RU31 A0A8I3RU31_CANLF Metallothionein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] LLLLPGGL 1 11.3 1.0044 -1.1044 0 0 0 0 0 4.5225 0 0 0 0 0 0 0 0 0 A0A8I3RU34 A0A8I3RU34_CANLF Protein phosphatase 1 regulatory subunit 18 PPP1R18 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] actin binding [GO:0003779]; phosphatase binding [GO:0019902] AQPDDDDDDDDDDD;DDDDDDDDDDDD;DDDDDDDDEELLL;EAWDWRQSPGE;EEERKDCLE;EWSLRLAEPAEQSPRRKEV;GAPSPPAAQPDDDDDDDDDDD;PAAQPDDDDDDDDDDDD;PDDDDDDDDDDDD;PDDDDDDDDDDDDE;PDDDDDDDDDDDDEE;PPAAQPDDDDDDDDDDDDEEL;QPDDDDDDDDDD;QPDDDDDDDDDDDDEE;SPGEPSPA;SSRLSEARKW 16 13.6 0.98744 -0.4649 4.57846 7.27612 3.10923 10.2367 5.21746 0 13.3478 6.98048 5.83059 10.9907 3.31623 0 4.93121 10.7886 8.77426 A0A8I3RU37 A0A8I3RU37_CANLF Solute carrier family 36 member 2 SLC36A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPFLVLLVLIRNLRVLTI;PLFFGTAIFSFESIGVSQVC 2 11.7 0.98993 -0.20048 0 0 0 0 0 0 9.42582 0 0 0 0 6.44897 0 0 0 A0A8I3RU38 A0A8I3RU38_CANLF Gap junction protein GJC2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; response to toxic substance [GO:0009636] connexin complex [GO:0005922]; myelin sheath [GO:0043209] gap junction channel activity involved in cell communication by electrical coupling [GO:1903763] AERARPHEPDLA;GADDAEAE;LVVRGGPG;NHSTFVGKVW;VISTPSVMYLGYAVHRLA 5 10.6 0.99865 -3.2718 0 0 0 9.5203 0 8.44746 0 0 0 7.73356 0 0 4.62895 0 0 A0A8I3RU39 A0A8I3RU39_CANLF Uncharacterized protein EGFL7 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ACSTYRTIYRTAYRHSSGPASPRPR;TLGSCSCC 2 6.7 1.0037 -1.0689 0 0 0 0 0 0 0 9.00475 0 7.24003 0 0 0 0 0 A0A8I3RU41 A0A8I3RU41_CANLF Vesicle-trafficking protein SEC22b (SEC22 vesicle-trafficking protein homolog B) Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle fusion with Golgi apparatus [GO:0048280]" endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; melanosome [GO:0042470]; SNARE complex [GO:0031201] SNAP receptor activity [GO:0005484] FQSGRDLQ;IEFDTYIQKTKKLYI 2 11.1 0.98708 -0.50262 0 0 0 8.27044 0 0 0 0 10.9218 0 0 0 0 0 0 A0A8I3RU43 A0A8I3RU43_CANLF Sp8 transcription factor SP8 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AHLRWHTGERPFVCNWLFCGKRFTR;GGGGGGGG;GPSAPLGGSPRSSAR;RYSGRATCDC 4 11.8 0.98934 -0.52205 0 0 9.24648 0 0 0 0 0 7.77406 0 0 7.78005 0 8.14787 0 A0A8I3RU51 A0A8I3RU51_CANLF Tripartite motif containing 41 TRIM41 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nuclear body [GO:0016604] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] EEDEEDGEEEEVEAVGA;EEEGVFWTSGMGGSNWDNMDYVWE;EFGRLTRFLA;EVEVGGRRGWAVGAA;RDELDREEDEEDGEEEEVEAVGA;VLGAQGFRSGRHYWE 6 15 0.985 -0.44449 0 5.42851 0 7.38931 7.63728 0 9.10523 0 0 0 10.2051 0 0 0 6.43823 A0A8I3RU71 A0A8I3RU71_CANLF "Failed axon connections homolog, metaxin like GST domain containing" FAXC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DDDNTIYESEESSE 1 3.4 0.93476 0.060769 0 0 0 9.10058 0 9.27968 0 0 0 0 0 0 0 0 0 A0A8I3RU73 A0A8I3RU73_CANLF Uncharacterized protein ZNF19 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ESSYLCDEC;HTKLTRHQRVH;PFECNECGKAFNGNS;PWGLEAQNNP;VLDICHFGLPEFFT 5 12.9 1.0021 -1.2774 0 8.57969 0 0 0 0 0 9.5853 0 0 9.03941 0 0 0 0 A0A8I3RU75 A0A8I3RU75_CANLF Pleckstrin homology and RUN domain containing M1 PLEKHM1 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029] endosome [GO:0005768]; lysosome [GO:0005764] metal ion binding [GO:0046872] DLCTQRGFICQICHHHDIIFPF;ETIRDILP;IPFDVPAEPLLAQAS;VGHPACHPTPIHSWPQLSR;VIKKKLVGSVKALQK;YQKPLNGKIHPPN 6 7.7 1.003 -1.5917 5.54077 9.25767 0 6.21692 6.33602 0 6.09236 8.61419 0 0 0 0 0 0 0 A0A8I3RU82 A0A8I3RU82_CANLF Ankyrin repeat domain 54 ANKRD54 Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular signal transduction [GO:1902531] cytoplasm [GO:0005737]; nucleus [GO:0005634] protein kinase regulator activity [GO:0019887] AADGGADD 1 2.8 1.0032 -1.1044 0 0 0 0 0 0 0 0 0 9.25529 0 0 0 0 0 A0A8I3RUA2 A0A8I3RUA2_CANLF FA complementation group G FANCG Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297]; mitochondrion organization [GO:0007005]; ovarian follicle development [GO:0001541]; response to radiation [GO:0009314]; spermatid development [GO:0007286] chromatin [GO:0000785]; cytosol [GO:0005829]; Fanconi anaemia nuclear complex [GO:0043240]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plasma membrane [GO:0005886] GVGAGTESPRESI 1 1.6 0.98421 -0.24753 0 0 0 0 0 0 10.1499 0 0 0 0 0 0 0 0 A0A8I3RUB4 A0A8I3RUB4_CANLF Tetraspanin 13 TSPAN13 Canis lupus familiaris (Dog) (Canis familiaris) regulation of calcium ion transmembrane transport [GO:1903169] plasma membrane [GO:0005886] calcium channel regulator activity [GO:0005246] GVWLTYRYRNQKD;VGIFLFLIAL 2 11.3 1.0028 -0.87045 0 0 0 0 10.0072 0 0 0 3.95578 0 0 0 0 0 0 A0A8I3RUB9 A0A8I3RUB9_CANLF Premelanosome protein PMEL Canis lupus familiaris (Dog) (Canis familiaris) LVSLIYRRRLLK;PSGATAVQMTTT;PTAEVISTTPGQVP;TAEIPGTTAGRVPTAE;TGKAVLGTHTMEVTVYHRRESQSYV 5 13.1 0.94251 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 5.74031 0 A0A8I3RUC1 A0A8I3RUC1_CANLF Uncharacterized protein LOC100684769 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] APTGVVKTTQ;LETCEVTPLLS 2 4.5 1.0038 -0.82546 0 0 0 0 0 0 0 0 10.2783 7.6844 2.3138 0 0 0 0 A0A8I3RUC5 A0A8I3RUC5_CANLF Nucleolar protein 12 NOL12 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] identical protein binding [GO:0042802] ERHQEYLKMLAEREEALEEADELER 1 11.7 0.99053 -0.2978 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.92521 A0A8I3RUC7 A0A8I3RUC7_CANLF Kinesin family member 27 KIF27 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of localization in cell [GO:0051649]; ventricular system development [GO:0021591] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AIEALEAAIEYKNESIQS;EQEEALKLKPEDPDAFKMKK;LHNHQACVRVIPN;TCIKPLVLSLIEGYNATVF;TSFTRSHGIGSLEDGPPHI;VLERDNMVCELESALES;VLFQLEEAIEALEAAIEYKNE 7 8.1 0.98907 -0.52492 7.92517 0 8.17193 0 7.06975 0 7.92523 3.48556 10.0896 8.37665 0 0 0 0 0 A0A8I3RUD5 A0A8I3RUD5_CANLF Regulatory factor X6 RFX6 Canis lupus familiaris (Dog) (Canis familiaris) glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; type B pancreatic cell differentiation [GO:0003309] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" AMETQFNNDKEQELQNLLDKYMKN;CQGATLPPNSPNGYYGS;DTVVEQRVIKTS;GTSSQYPAQETLD;ISPAMASRGSVINQGP;SPQASPEA 6 9.8 1.0034 -1.6149 10.5304 0 0 8.94676 0 0 12.5136 0 0 0 9.61568 10.0018 0 0 0 A0A8I3RUE1 A0A8I3RUE1_CANLF FANCD2 opposite strand FANCD2OS Canis lupus familiaris (Dog) (Canis familiaris) PPKWTGTFRVSDKSA;PSDLEVQLCFQEVTLV;SILLLYATYK 3 23 0.98917 -0.50789 0 0 0 0 8.92455 0 0 0 0 0 0 0 0 6.95524 0 A0A8I3RUE4 A0A8I3RUE4_CANLF Angel homolog 1 ANGEL1 Canis lupus familiaris (Dog) (Canis familiaris) 3'-5'-RNA exonuclease activity [GO:0000175] AESCENGNRTDRRLYQDGTL;ANLMQEFQHWDP;EDALEPEPVFPR;EDHYWEQLEPS;NLMQEFQHWDPDILCLQ;PLGLGTTVDYIFFSA;RGDVKLAQ 7 13.4 1.0015 -0.70042 6.31786 9.25892 4.36884 0 0 0 6.00421 0 0 0 0 0 0 8.41912 8.64893 A0A8I3RUG2 A0A8I3RUG2_CANLF KIAA1217 KIAA1217 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813] ASAYCNPSLQAEMH;ASPRSLLVLDEAPTA;EQSLYRQKSRKYPES;ETSGDSLEAMSE;FQSPTHAGKGHHL;KCSQADSPGAESKAD;QYGDETKQLRMPN;RMMTEDKIEEEEEEEEE;SLSDASRTSEYK;VLSSGEVRDIVSKKGEDVQ 10 7.2 1.0027 -0.77335 0 0 0 12.0761 6.39386 7.31714 6.58486 0 8.6743 8.56148 11.7559 7.11114 0 0 0 A0A8I3RUG4 A0A8I3RUG4_CANLF tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) DTWD2 Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] transferase activity [GO:0016740] QETLLRPLQALCSF;TLLRPLQALCSFQLQ;VISLYFEHLQDFFFFLPFSRPQEV 3 16.7 0.99374 -0.16358 0 0 0 0 0 9.7132 0 0 9.92606 0 0 0 0 0 8.37278 A0A8I3RUI3 A0A8I3RUI3_CANLF Protein tyrosine kinase 7 (inactive) PTK7 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808] axon [GO:0030424]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] HYMVLEYVDLGDLKQ;QQCMEFDK;TVYQGHTAL 3 3.2 1.0031 -1.0306 0 0 0 9.63769 0 9.6591 0 0 0 0 0 0 0 0 0 A0A8I3RUI8 A0A8I3RUI8_CANLF Pecanex-like protein PCNX1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALKYVLYALV;ASQSSYCYSS;DFPLYQQRRGLD;EDEGFCCC;EDEGFCCCE;EGFCCCEP;HSSVSQGSAGN;KLEEWLANETMQEGLRLCAD;MSCTSNNATSASDP;RRYLSFRVI;TEEAAQKVK;VASLVPLHSH;VGMGSQTL 13 5 0.99658 -4.9436 0 16.8665 16.8306 16.8202 16.8416 16.821 7.51861 14.678 9.36643 14.7088 14.5794 14.4282 16.5141 16.471 0 A0A8I3RUJ0 A0A8I3RUJ0_CANLF MDM2 binding protein MTBP Canis lupus familiaris (Dog) (Canis familiaris) regulation of protein ubiquitination [GO:0031396] ECFEEEDSNS;FFTSDGLPIGDL;FVLPCTIS;TSDGLPIGDL 4 3.6 1.004 -1.9912 0 0 0 0 0 8.22757 11.1365 0 0 0 0 0 0 0 8.21791 A0A8I3RUJ2 A0A8I3RUJ2_CANLF X-ray radiation resistance associated 1 XRRA1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nuclear body [GO:0016604] EQRLMNQKQ;FRIPYLQQ;KGSQQENQEDIPGH;KSFLQERLGIHLIRRKIVKAK;PVEGLEGLS 5 7.6 1.0019 -1.2556 11.3045 6.19129 0 0 0 0 0 0 0 0 10.1854 0 0 5.88345 0 A0A8I3RUJ8 A0A8I3RUJ8_CANLF Neurotrimin NTM Canis lupus familiaris (Dog) (Canis familiaris) EPTSSTLLQGPG;LPTLGIVWR;NVSEHDYGNYTC;YGNYTCVASNKLGHTNASITLFE;YTCVASNKLG 5 13.9 0.98248 -0.2498 11.9919 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RUL0 A0A8I3RUL0_CANLF AP-1 complex subunit gamma PHLPP2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886] AP-1 adaptor complex [GO:0030121] clathrin adaptor activity [GO:0035615] GVLHTSVVLLTEMCERSP;RKVRILRLLRIL;TLGCMGSSEMCRDLA;VDCLKDLDVSI 4 7.1 0.94439 0.05044 0 0 0 0 0 0 5.64426 0 0 0 0 0 0 0 0 A0A8I3RUL4 A0A8I3RUL4_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC22 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] palmitoyltransferase activity [GO:0016409] LAFLTLLPTSI;LILRGQTRHQVRK;VLVIQNSPEDLDACQ 3 14.8 0.98739 -0.23443 0 0 0 6.28755 0 0 0 0 0 7.27771 0 0 0 0 0 A0A8I3RUM3 A0A8I3RUM3_CANLF VWFD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix [GO:0031012]; extracellular space [GO:0005615] LSWDRKTSVFIRLRQDYKGRVCGL;QCGCYDEDGNYHDVG;TAVAAYAQACRDVGVCVS;VGDACACDLGGDCEC;VSDGSGGCVAEEDCP;VTENVPCGTTGVTCSKAIK 6 23.7 0.83921 0.19737 0 0 0 0 9.99788 0 0 8.96298 0 0 0 0 0 4.9986 5.79834 A0A8I3RUM4 A0A8I3RUM4_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; phosphatidylcholine catabolic process [GO:0034638]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; sphingolipid catabolic process [GO:0030149] extracellular space [GO:0005615] alkylglycerophosphoethanolamine phosphodiesterase activity [GO:0047391]; calcium ion binding [GO:0005509]; lysophospholipase activity [GO:0004622]; nucleic acid binding [GO:0003676]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; zinc ion binding [GO:0008270] EDNACHCSEDCLAKGDC;ESCNSSEDESQ;GSGLGNVP;GVPEYLTNCVRPD;HRPDNEESCNSSEDES;LNHLLRTHTFR;LTILQWLTLP;PEEVTRPNYPGIMYLQ;SYSSCCHDFD;TRYDILYHTD;YLQSDFDLGCNCDD 11 12.8 0.99019 -0.26592 0 11.2178 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RUM9 A0A8I3RUM9_CANLF Ataxin 1 like ATXN1L Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; extracellular matrix organization [GO:0030198]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; social behavior [GO:0035176]; transcription by RNA polymerase II [GO:0006366] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; POZ domain binding [GO:0031208]; RNA binding [GO:0003723] AEGATPPPQASSP;AQLPSTSLQFIGSPYSLPYAVPPN;GASPILTP;GSARNPAEMAEKNQARGFYP;PAEMAEKNQARGF 5 9.5 0.98713 -0.33586 0 0 10.3225 0 9.61844 0 0 8.47297 0 10.376 0 0 0 7.18051 0 A0A8I3RUN9 A0A8I3RUN9_CANLF Transmembrane protease serine (EC 3.4.21.-) LOC119881700 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] VVAGVVILAVTIALLIHFLA 1 5 0.97337 0.048206 0 7.57478 0 0 0 0 0 10.6935 0 0 0 0 0 0 0 A0A8I3RUP9 A0A8I3RUP9_CANLF Uncharacterized protein MLX Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] LFQSFNASISVASFQ;RCPSLWVAH;TDDEDSDYHQ;VPPPFGPRGCRE 4 9.2 1.0045 -1.0954 0 0 0 5.42596 0 0 0 0 0 0 0 0 10.5903 10.9968 0 A0A8I3RUQ1 A0A8I3RUQ1_CANLF DDB1 and CUL4 associated factor 13 DCAF13 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" nucleolus [GO:0005730]; small-subunit processome [GO:0032040] AVFATCGQQVDIWDE 1 8.1 0.98747 -0.2305 0 0 0 0 0 0 0 0 0 0 8.83933 0 0 0 0 A0A8I3RUQ2 A0A8I3RUQ2_CANLF Transmembrane protein 63C TMEM63C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium-activated cation channel activity [GO:0005227] EQASIRFQC;IHMAAVYQAIF;KTYSVRNRERK;LFFSILRLGTLH;VTRTLMITYVPKDIQDPE 5 7.8 0.98918 -0.2606 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8407 A0A8I3RUR2 A0A8I3RUR2_CANLF Pleiotrophin (PTN) PTN Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083]; heparin binding [GO:0008201] SRMQSQQYVQQRRK 1 6.9 0.99094 -0.26796 0 0 10.8976 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RUR3 A0A8I3RUR3_CANLF Lutropin-choriogonadotropic hormone receptor LHCGR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] luteinizing hormone receptor activity [GO:0004964] ALLPVLLPVLPVLLLLLLL;ALLPVLLPVLPVLLLLLLLP;LLLLLLLP;LLPVLLPVLPVLLLLLLL;LPVLLLLLLLPPRARPG;LPVLLPVLPVLLLLLLLP;LPVLPVLLLLLLL;PALLPVLLPVL;PVLLPVLPVLLLLLL;PVLLPVLPVLLLLLLLPPRA;RGPALLPVLLPVLPVLLLLLLLPP;VLLPVLPVLLLLL;VLLPVLPVLLLLLLLPPRAR;VTVLFVLLTSRYKLTVPR 14 6.9 0.98677 -0.39538 6.5456 7.15015 8.00804 0 0 6.21115 0 5.49429 5.52754 0 0 4.96735 0 0 0 A0A8I3RUR5 A0A8I3RUR5_CANLF Interleukin 20 receptor subunit alpha IL20RA Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124] interleukin-20 binding [GO:0042015] DSEGCSHPEYEEFT;GVPAPGRQALRLLLLLLLLAAA;LLLLLLLL;LYSYVPQLRDLDQRQWEHPDTRKEP;MKFMEEWGLY;RLLLLLLL;RLLLLLLLL 7 12.7 1.0019 -0.67584 0 0 0 0 0 8.6962 0 0 6.36126 4.54195 0 0 0 0 0 A0A8I3RUR8 A0A8I3RUR8_CANLF Atlastin GTPase 3 ATL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GGMSFLDKRLQ 1 2.2 0.98905 -0.19891 0 13.108 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RUS6 A0A8I3RUS6_CANLF Muscarinic acetylcholine receptor CHRM2 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of heart contraction [GO:0008016]; regulation of smooth muscle contraction [GO:0006940]; response to virus [GO:0009615]" cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793] arrestin family protein binding [GO:1990763]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993] HYKNIGATSE;NSSSNGLA;QNIVARKIVKM 3 6 1.0013 -0.9195 10.0164 5.70282 0 8.12283 0 2.78756 0 4.38757 0 9.06687 0 4.43863 0 8.20208 8.30948 A0A8I3RUT9 A0A8I3RUT9_CANLF Cell division control protein CDC6 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA replication initiation [GO:0006270] nucleus [GO:0005634] ATP hydrolysis activity [GO:0016887] SLLLLIRQLKIKEVTLGKL;TAVPDRLPAREKEM 2 6.1 0.91343 0.11035 0 0 0 0 0 7.03529 0 0 0 0 6.25569 0 6.27568 0 0 A0A8I3RUV9 A0A8I3RUV9_CANLF "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; male meiotic nuclear division [GO:0007140]; regulatory ncRNA-mediated gene silencing [GO:0031047]; retrotransposon silencing [GO:0010526]; spermatogenesis [GO:0007283] pi-body [GO:0071546] DGWEIGYLDRAV;EKNETFKKAL;ERDITLRHLL 3 6.7 0.9867 -0.45859 0 8.43605 0 0 0 13.2149 0 12.4296 0 12.1803 0 0 0 0 0 A0A8I3RUW0 A0A8I3RUW0_CANLF "Thioredoxin reductase 1, cytoplasmic (EC 1.11.1.2) (EC 1.8.1.9) (Peroxidase TXNRD1) (Thioredoxin reductase TR1)" TXNRD1 Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454] flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791] HGVKFIRQFV;SGSTSTSLLDP;TDEEQTNVPYI 3 4.9 0.98547 -0.4348 0 0 0 0 0 0 0 0 11.2016 0 5.09525 0 0 0 0 A0A8I3RUW7 A0A8I3RUW7_CANLF Olfactory receptor family 56 subfamily A member 1 OR56A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFIVTRNALLTAP;CTFMVMAY;QLHYCGKNVIENCICANL 3 12.3 0.94292 0.059672 0 0 0 0 0 0 0 0 0 0 0 0 0 4.73861 0 A0A8I3RUW9 A0A8I3RUW9_CANLF PML-RARA regulated adaptor molecule 1 PRAM1 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229]; protein localization to plasma membrane [GO:0072659]; T cell receptor signaling pathway [GO:0050852] plasma membrane [GO:0005886] KPPKPEFNKLLKKFPPP;LPKKPPLPGSVSES;LPPTDLKSLKQIRKAEKAEREFRK;PEVSVFPKRPRQS;QDILQDPDE;TEFFGDLP 6 14.1 1.0021 -1.2407 0 6.47455 0 0 0 0 0 0 9.28353 0 7.16098 7.26885 0 0 10.4298 A0A8I3RUX3 A0A8I3RUX3_CANLF Essential for reactive oxygen species protein CYBC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSQSSDSEADG 1 6.4 0.98121 0.035491 0 0 0 0 0 0 0 0 0 0 0 10.1118 0 0 0 A0A8I3RUX5 A0A8I3RUX5_CANLF BICRA like chromatin remodeling complex associated protein BICRAL Canis lupus familiaris (Dog) (Canis familiaris) PANHDQFHLVPNHIV 1 1.4 0.98387 -0.24442 0 0 0 8.77027 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RUX9 A0A8I3RUX9_CANLF Galectin LGALS12 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] DEAAHVPVTLRASFADR;LQHGHWQAEARWPHLTLQ 2 11.5 0.99462 -0.018973 0 0 5.82512 0 10.2713 0 0 0 0 0 0 0 0 0 0 A0A8I3RUY1 A0A8I3RUY1_CANLF IST1 homolog (Charged multivesicular body protein 8) IST1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] LGSGFKAERLRVNLRLVINRLKLL;VEHIIREDYLVEAMEIL;VGGPDGTV 3 14.6 1.0018 -1.2882 9.88573 0 5.48546 0 8.06926 0 0 0 0 0 0 0 0 0 0 A0A8I3RUZ0 A0A8I3RUZ0_CANLF Homer scaffold protein 1 HOMER1 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to cocaine [GO:0048148]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; positive regulation of calcium ion transport [GO:0051928]; regulation of calcium ion import [GO:0090279]; regulation of store-operated calcium entry [GO:2001256]; response to calcium ion [GO:0051592]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741] apical part of cell [GO:0045177]; axon [GO:0030424]; costamere [GO:0043034]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; Z disc [GO:0030018] G protein-coupled glutamate receptor binding [GO:0035256]; transmembrane transporter binding [GO:0044325] HHLSKFAEKFQ;QNEQEAFRNNL 2 6.2 0.98922 -0.2033 0 0 0 0 11.843 0 0 9.8883 0 0 0 0 0 0 0 A0A8I3RUZ2 A0A8I3RUZ2_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2J1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DFCCEGCGCAMKDV;MSPRQRRAQQQSQRRSS;QPRDNHTDHGGSAV 3 14.4 0.85714 0.16813 0 0 0 0 0 0 9.07098 5.3455 0 0 0 0 0 0 0 A0A8I3RUZ3 A0A8I3RUZ3_CANLF Sodium/hydrogen exchanger SLC9A5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of intracellular pH [GO:0051453] focal adhesion [GO:0005925]; neuron spine [GO:0044309]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202] arrestin family protein binding [GO:1990763]; sodium:proton antiporter activity [GO:0015385] AEEPQPFHLPYDPRP;APRVQASFLD;EDAQERQDKEVF;EDDEGIIFVARATNEV;ELPWKSGQGDL;FFTVIVQG;GVVLQTWVLNQFRLVPLDK;HYWRDRWEQFDKKYLSQLLMRRSAY;LPLAGAAATEEPTREPGSPGE;VLDSGYFMPSRLFFDNLGAI;VYVSSETTKIVPVDMQAGWN;YQLEPGTFFL 12 20.8 1.0006 -2.7586 9.09024 0 0 0 0 9.70776 0 0 9.16418 5.06682 9.32791 0 3.13368 9.2502 0 A0A8I3RV02 A0A8I3RV02_CANLF Upregulator of cell proliferation URGCP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525] LAFCDPEKQH;QHVWHIPG;WRDMDADDCEFYCGNGTN 3 3.7 1.0023 -1.3724 0 0 8.57682 0 0 0 8.5409 0 0 0 0 0 0 0 0 A0A8I3RV11 A0A8I3RV11_CANLF Ribonuclease P/MRP subunit p21 RPP21 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] ETSLLEAGASAASTAAALE;KQLQAVKRK 2 5.7 1.0016 -0.75228 0 0 0 0 0 9.21106 0 0 0 0 0 0 0 0 2.91938 A0A8I3RV28 A0A8I3RV28_CANLF "Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (Nucleoside diphosphate-linked moiety X motif 1)" NUDT1 Canis lupus familiaris (Dog) (Canis familiaris) DNA protection [GO:0042262] nucleus [GO:0005634] "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; metal ion binding [GO:0046872]" AGPLTCPLRSPQP;EESGLTVDTLHKVGQIMFE;GVQPHWPIVQ;INKTLKKKKKKKL;INKTLKKKKKKKLKGPP;KKKKKLKG;KTLKKKKKKKL;KTLKKKKKKKLK;KTLKKKKKKKLKGPPGRS;LKKKKKKKLKGP;NKTLKKKKKKKLK;RPQWFQLDQ;TLKKKKKKKLKG;TLKKKKKKKLKGP;TLKKKKKKKLKGPP 15 12 1.0022 -1.2367 6.61706 6.10226 14.259 0 0 0 6.23471 11.0491 0 0 0 9.60246 4.10827 0 0 A0A8I3RV33 A0A8I3RV33_CANLF Tight junction associated protein 1 TJAP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALGSPIPQPNGECHSLGTAGASPE;ELEIGQDCLELEL;GRAWALPS;LAEDVFVH;LSPTDRDEEVLAPSPPGESG;NSYTASQRTNQELEDKL;PHREPSPLPPALHA;PVPSSPASAQASPHREPSP;RHFALSPTDRD;RKDSLTQAQEQGN 10 24.1 0.98809 -0.47424 0 0 0 5.70625 10.8882 0 10.1219 8.4463 8.29366 0 0 12.4166 0 0 0 A0A8I3RV36 A0A8I3RV36_CANLF Glycine N-methyltransferase (EC 2.1.1.20) GNMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; regulation of gluconeogenesis [GO:0006111]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethionine metabolic process [GO:0046500]; sarcosine metabolic process [GO:1901052] cytosol [GO:0005829] folic acid binding [GO:0005542]; glycine binding [GO:0016594]; glycine N-methyltransferase activity [GO:0017174]; identical protein binding [GO:0042802]; S-adenosyl-L-methionine binding [GO:1904047] DVPQPPGGAFDAV;LDYTVQVPGAGQ;PGQASIPCYFIHV;VICLGNSFAHLPDC 4 17.3 0.99152 -0.29572 0 0 0 0 0 0 0 9.57518 10.774 0 0 8.38085 0 14.6548 8.77403 A0A8I3RV51 A0A8I3RV51_CANLF Olfactory receptor OR2D37 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GEGNQTTVAEFILLGLSQDPK;HLTVVVLYYGSG;PKIQILLFCV 3 13.4 0.99195 -0.1802 0 0 0 11.4666 11.6334 0 11.0537 4.96804 0 9.65573 0 0 0 10.8788 0 A0A8I3RV75 A0A8I3RV75_CANLF Uncharacterized protein ZNF775 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] AAEPQRPGQAARDAAPRS;LQELLRDAATRRSCR;VLSEKDKENIFQQ 3 8.7 0.99426 -0.059277 0 0 9.50898 0 0 0 0 0 0 0 9.54272 0 6.2762 0 0 A0A8I3RV79 A0A8I3RV79_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] SPAGDGEE 1 8.6 1.0044 -1.1044 0 0 0 0 0 0 0 0 7.89748 0 0 0 0 0 0 A0A8I3RV83 A0A8I3RV83_CANLF Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) PPP1R10 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; positive regulation of telomere maintenance [GO:0032206] "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; PTW/PP1 phosphatase complex [GO:0072357]" metal ion binding [GO:0046872]; protein phosphatase inhibitor activity [GO:0004864] EGKLREYFYFELDET;GIKIKKKKKVLSPTAAKPSPFEG;IKIKKKKKVL;LFLNKESPHE;LVTPGSNSQERYIQ;PGIKIKKKKKVL;PVPGIKIKKKKKVLSP;QGPGGGGI;TPGSNSQERYIQAE;VTWPEEGK 10 8.5 1.0035 -2.2465 11.3331 7.57456 7.93463 0 0 9.46144 4.9364 0 11.0774 8.80352 9.41504 11.0715 0 2.62237 5.31219 A0A8I3RV84 A0A8I3RV84_CANLF Docking protein 3 DOK3 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] cytoplasm [GO:0005737] VEASKRGLVPMEEN 1 3.1 0.94224 0.061052 9.51704 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RV91 A0A8I3RV91_CANLF POU domain protein POU3F2 Canis lupus familiaris (Dog) (Canis familiaris) cerebral cortex radially oriented cell migration [GO:0021799]; epidermis development [GO:0008544]; forebrain astrocyte development [GO:0021897]; forebrain ventricular zone progenitor cell division [GO:0021869]; hypothalamus cell differentiation [GO:0021979]; myelination in peripheral nervous system [GO:0022011]; negative regulation of gene expression [GO:0010629]; neuroendocrine cell differentiation [GO:0061101]; neurohypophysis development [GO:0021985]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of multicellular organism growth [GO:0040018]; regulation of axonogenesis [GO:0050770]; regulation of cell differentiation [GO:0045595] nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AAHLPPSM;EPHHADHHPHPH;GGGGGGGD;GGGGGGGG;HHDPHSDE;QQPPPPPPPQ 6 13.5 1.0027 -2.5264 0 5.02622 10.1874 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVA6 A0A8I3RVA6_CANLF GPALPP motifs-containing protein 1 GPALPP1 Canis lupus familiaris (Dog) (Canis familiaris) DDDDDDDDDDEGFFGPAL;DDDDDDDDEGFFG;DDDDDDDDEGFFGP;HVLSGREKRLAE;KRSESLMD;NQDDDDDDDDDD;QDDDDDDDDD;YEEENQESEEDDTG 8 15.3 0.93323 0.098753 0 0 7.07489 0 0 0 0 6.14889 0 0 0 0 0 0 0 A0A8I3RVA9 A0A8I3RVA9_CANLF Muscarinic acetylcholine receptor CHRM1 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of monoatomic ion transport [GO:0043270]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of locomotion [GO:0040012]; regulation of postsynaptic membrane potential [GO:0060078]; saliva secretion [GO:0046541]" cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685] G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993] FGTAMAAFYLPV;LVLISFKVNTELKTVNNY;PETLWELGYWL;WALGTLACDLW 4 11.3 0.99144 -0.13681 0 0 0 9.46756 0 0 8.37491 0 0 8.19668 8.6844 0 0 0 0 A0A8I3RVB1 A0A8I3RVB1_CANLF Olfactory receptor family 10 subfamily A member 5D OR10A5D Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TQMYFSFFF 1 3 1.0041 -0.80421 0 0 8.60903 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVC5 A0A8I3RVC5_CANLF RanBP2-type domain-containing protein RYBP Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] GAGGGGGG;KNVDRSTAQQLAV;KSARFLRPPRPFPGRRRRRRRRRLP;PEKDKEIS 4 11.5 0.9877 -0.36679 0 0 0 0 0 0 0 11.1319 0 0 0 0 6.87811 0 0 A0A8I3RVD0 A0A8I3RVD0_CANLF phenylalanine 4-monooxygenase (EC 1.14.16.1) PAH Canis lupus familiaris (Dog) (Canis familiaris) L-phenylalanine catabolic process [GO:0006559] iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505] EDNIPQLEEVSQFL;FREDNIPQL;SPRPAVLGWPAPPNP;VLEHRGSGSKLSD 4 8.1 1.0038 -0.80613 0 0 0 0 0 6.66121 0 0 0 0 0 0 0 0 0 A0A8I3RVD1 A0A8I3RVD1_CANLF Cyclin D binding myb like transcription factor 1 DMTF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DINWDLLAEG;GVPNSNSNSSVQHVQIR;PVQITHVSSSESPAATVDSETI;RVLRMYDDRNHV;SPAATVDSETITLNSGTLQ;VIIQTVATED 6 11 1.002 -1.2718 0 0 16.9536 0 8.24512 8.82232 0 0 0 0 0 0 6.72547 0 0 A0A8I3RVD6 A0A8I3RVD6_CANLF asparagine--tRNA ligase (EC 6.1.1.22) NARS2 Canis lupus familiaris (Dog) (Canis familiaris) asparaginyl-tRNA aminoacylation [GO:0006421] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] TFTPEWGVDLHTEHEKYLV 1 4.4 0.95329 0.049489 0 0 10.0619 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVE5 A0A8I3RVE5_CANLF Integrin beta ITGB8 Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; cell adhesion [GO:0007155]; ganglioside metabolic process [GO:0001573]; hard palate development [GO:0060022]; immune response [GO:0006955]; integrin-mediated signaling pathway [GO:0007229]; Langerhans cell differentiation [GO:0061520]; negative regulation of gene expression [GO:0010629]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; response to virus [GO:0009615]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570] cell surface [GO:0009986]; integrin alphav-beta8 complex [GO:0034686] extracellular matrix protein binding [GO:1990430] DLSRKMAYFSRDFR;GHGECEAGRCQCFSGWEGDRC;IVTFLIGLLKVLIIRQVIL;KISGNIDTPEG;LNAHETFSHRR;SYLRIFFIIFIVTFLIGLLKVLII;TSCALMEQHYME;VSPYISIHP 8 13.7 1.0036 -1.0678 0 0 0 0 9.00422 8.96229 0 8.50577 0 0 9.66064 0 0 6.78934 7.19869 A0A8I3RVE6 A0A8I3RVE6_CANLF LHFPL tetraspan subfamily member 4 LHFPL4 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid receptor clustering [GO:0097112]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of inhibitory synapse assembly [GO:1905702]; sensory perception of sound [GO:0007605] GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572] GABA receptor binding [GO:0050811] RPGGDVSGWGVL;TDLLQEELKQ;TVYKICAWMQL 3 13.4 1.0028 -0.78606 11.6309 0 0 0 0 0 0 0 0 10.1866 0 0 0 0 0 A0A8I3RVG0 A0A8I3RVG0_CANLF Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) NR1D1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; circadian temperature homeostasis [GO:0060086]; glycogen biosynthetic process [GO:0005978]; intracellular glucose homeostasis [GO:0001678]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of DNA-templated transcription [GO:0045893]; proteasomal protein catabolic process [GO:0010498]; protein destabilization [GO:0031648]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of fat cell differentiation [GO:0045598]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to leptin [GO:0044321] chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; nuclear body [GO:0016604] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; heme binding [GO:0020037]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]" EQLQETLLRALRALVLKNRP;FDFSEKLNSL;PLVGFSQFPQQLTPP;QDPARSFG;SRTTYSLQE 5 10.1 0.97278 0.048206 5.99209 0 0 0 11.6637 0 6.62756 6.97016 0 0 0 0 0 0 6.33179 A0A8I3RVG6 A0A8I3RVG6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NLSPPSAAFLPWMPTPV 1 10.6 0.98518 -0.24084 0 10.2511 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVI1 A0A8I3RVI1_CANLF Leucine rich repeats and calponin homology domain containing 1 LRCH1 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;LSPEFQPEPSLLG;PFCMHIFKYLSI;RNLESIDPQFT;VLRSEFITYIKDRTEDCEELLRIEE 5 11.1 0.98766 -0.3998 0 7.89815 0 0 0 0 0 0 0 0 0 10.7393 0 10.0505 9.85594 A0A8I3RVI5 A0A8I3RVI5_CANLF Phosphatidylinositol glycan anchor biosynthesis class S PIGS Canis lupus familiaris (Dog) (Canis familiaris) attachment of GPI anchor to protein [GO:0016255] GPI-anchor transamidase complex [GO:0042765] PILLSLVKIFL;VISEHSSLLPQDMMSYIG;WDIEGAVQ;YLAAHSLP 4 8.2 1.002 -0.65505 11.0916 10.9209 0 0 0 0 11.0733 11.2831 11.2827 0 0 9.31188 0 0 0 A0A8I3RVJ2 A0A8I3RVJ2_CANLF Coiled-coil domain containing 149 CCDC149 Canis lupus familiaris (Dog) (Canis familiaris) EVSGLWSLPG;GVARRHQMACRGDAPKSRPGS 2 6.1 1.003 -0.85812 0 0 0 0 0 0 0 0 8.53493 0 0 10.2434 0 0 0 A0A8I3RVJ7 A0A8I3RVJ7_CANLF Inhibitor of Bruton tyrosine kinase IBTK Canis lupus familiaris (Dog) (Canis familiaris) APRQVSALHHKD;DILEVILDYLYT;DILEVILDYLYTD;DSIHDVTFQVGNRI;EEYQGTMNSHSNKMH;ESMFKKAKTKAKKKPRKR;IFPAHKYILAV;LVSGGRMEYKVDPE;MNSHSNKMHCHEDNQ;PEEYQGTMNSHS;TDVYTWGDNTNFT;VIKVTLKNATMVL 12 9.8 0.67766 0.29284 9.21531 13.7978 8.55896 0 9.01106 0 0 10.0565 0 6.40995 8.19131 0 10.0358 0 13.3571 A0A8I3RVK4 A0A8I3RVK4_CANLF "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B" MGAT4B Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]" RLHAAEQE 1 1.5 0.98718 -0.2351 0 0 0 9.65937 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVL8 A0A8I3RVL8_CANLF Cathepsin D (EC 3.4.23.5) CTSD Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] aspartic-type endopeptidase activity [GO:0004190] YYTVFDRDQNRVG 1 3.3 0.98812 -0.26074 0 0 0 0 0 0 0 0 0 0 8.57069 0 0 0 0 A0A8I3RVM7 A0A8I3RVM7_CANLF Receptor activity modifying protein 2 RAMP2 Canis lupus familiaris (Dog) (Canis familiaris) AALRLLLLLGAVL;PAALRLLLLL;YSIAWSILQKHL 3 23 0.98746 -0.50142 0 4.23726 0 0 0 0 8.21854 8.83102 0 0 0 0 7.2791 0 0 A0A8I3RVP5 A0A8I3RVP5_CANLF SLIT-ROBO Rho GTPase activating protein 1 SRGAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] DLIDCCDL;MAGDDYCDSPYSEHG;TIQDMVTIEDYDV;TTRPPNVPPKPQ;VNDIKNSFERGENP 5 5.7 1.0032 -0.86783 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.24679 A0A8I3RVQ1 A0A8I3RVQ1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DQCQSHIC;ICMDFYGDCWFG;VLHSTFINGKTTCKWQFV;VLHSTFINGKTTCKWQFVEEWHTQP 4 7.6 1.0023 -1.3002 0 12.0823 0 0 0 0 8.56777 0 0 0 0 0 0 9.19328 0 A0A8I3RVQ4 A0A8I3RVQ4_CANLF aldehyde dehydrogenase (NAD(+)) (EC 1.2.1.3) ALDH7A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] aldehyde dehydrogenase (NAD+) activity [GO:0004029] LAAVEDAKKEGGTVV;SIESFRGFAWIFFFFFFFFFFLNFL;TAMAKDERVN 3 8.8 0.97463 0.035538 0 0 0 0 0 0 0 0 6.89276 0 0 0 0 0 0 A0A8I3RVQ5 A0A8I3RVQ5_CANLF Canopy FGF signaling regulator 2 CNPY2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of gene expression [GO:0010629]; regulation of low-density lipoprotein particle clearance [GO:0010988] LTELLEEVCDRMK 1 7.1 0.94361 0.061702 0 0 0 0 0 0 11.3892 0 0 0 0 0 0 0 0 A0A8I3RVR2 A0A8I3RVR2_CANLF "FOS like 2, AP-1 transcription factor subunit" FOSL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" TEELEEEKSGLQKEIAEL;WMVQPTVITSMS;YGEEPLHTPI 3 12.3 1.0013 -0.64338 0 14.1096 0 10.1724 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVR9 A0A8I3RVR9_CANLF Radial spoke head protein 9 homolog RSPH9 Canis lupus familiaris (Dog) (Canis familiaris) axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; radial spoke assembly [GO:0062177] kinocilium [GO:0060091]; radial spoke head 1 [GO:0120336]; radial spoke head 3 [GO:0120338]; sperm flagellum [GO:0036126] ADLDPSLDFMDSLEHD;PSLDFMDSLEHD;SLLWPGLT;YRYSRVLFWGRILGLVADYYI 4 16.3 0.94864 0.050031 0 0 0 7.93038 7.56879 0 0 0 0 0 0 0 0 0 0 A0A8I3RVS0 A0A8I3RVS0_CANLF PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) PAN2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606] nucleus [GO:0005634]; P-body [GO:0000932]; PAN complex [GO:0031251] metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; poly(A)-specific ribonuclease activity [GO:0004535] AELRSDGTKSTIKPSQ;AVETPGVTIMRQTN;CLACELGFLFHMLDL;GPNEGIPFIDDYI;IGYAPNPRTRLRN;LFSCEMENCSLCRCGSE;WSQDLLPL 7 8 0.99524 -0.56367 0 11.0318 6.0098 0 0 0 7.93003 0 9.12298 0 0 0 4.79753 12.8634 0 A0A8I3RVT3 A0A8I3RVT3_CANLF Mitochondrial ribosomal protein S18A MRPS18A Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GMLPRRITGLCQEE;RWNLKHKYSYEDVLL 2 22.8 0.9172 0.11499 0 0 0 0 0 8.33686 0 8.54071 0 7.25635 0 0 0 0 0 A0A8I3RVT6 A0A8I3RVT6_CANLF GRB2 associated binding protein 2 GAB2 Canis lupus familiaris (Dog) (Canis familiaris) CGFNQAEESTDSLR;SQSVYIPMSPG;TEFRDSTYDLPRSL;VSHSQWHQQSSPEE;YVPMSSVCVSHSQWH 5 10 0.98874 -0.52314 0 5.24952 10.5917 0 0 0 0 0 0 0 8.35451 8.60507 10.3295 0 0 A0A8I3RVT7 A0A8I3RVT7_CANLF Epithelial stromal interaction 1 EPSTI1 Canis lupus familiaris (Dog) (Canis familiaris) PQSSTWKLPVLPGNHSWA 1 6.1 0.98456 -0.25716 0 7.94451 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVU1 A0A8I3RVU1_CANLF Vacuolar-sorting protein SNF8 SNF8 Canis lupus familiaris (Dog) (Canis familiaris) protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] ESCRT II complex [GO:0000814] LIRAIKKLKALGTGFGIIPVGG 1 8.5 0.97373 0.046699 0 0 0 0 0 0 0 0 0 6.45301 0 0 0 0 0 A0A8I3RVV7 A0A8I3RVV7_CANLF WD repeat domain 97 WDR97 Canis lupus familiaris (Dog) (Canis familiaris) DVLVRLLNLDRPPSLE;EEEEEEEEEEEEEEEEEEEEEEER;EEEEEEEEEEEEEEEEEEEEEERN;EEEEEEEEEEEEEERNLDWASDYL;EEMIHWLQMES;ESQQESTV;GEEEEEEEEEEEEEEEEEEE;LDCTVRIWTAENR;LIQWLGEEEEEEEEEEEEEEEEEE;LNFFCEQQRV;LPAAPRALLPT;LTHGLELLRHL;LVHSSLSSSLGLSLDLQLQ;NDLFPEPVPPLFTSS;RPPSLEDPTQ;RYHQKLIQWLGEEEEEEE;SETLLHFSLSE 17 11.4 0.99741 -3.4945 7.46475 9.45728 11.0629 9.23776 9.31583 11.5755 11.8964 12.399 7.97361 10.7053 0 7.40523 0 0 11.5031 A0A8I3RVW0 A0A8I3RVW0_CANLF Uncharacterized protein LOC102152723 Canis lupus familiaris (Dog) (Canis familiaris) ETISCVQGIAPSQS 1 2.7 0.99571 -0.014874 10.8258 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVW4 A0A8I3RVW4_CANLF "Alpha-(1,3)-fucosyltransferase (EC 2.4.1.-)" FUT11 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] alpha-(1->3)-fucosyltransferase activity [GO:0046920] YLNGFECFVCDH 1 2.4 0.99315 -0.28317 0 9.74836 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVW6 A0A8I3RVW6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534] Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] AEPLYGPQG;PEDPHPLSAVAGR;TMEFYCEACETAMCGEC 3 5.2 0.99339 -0.18754 9.73064 0 0 0 0 0 8.25611 0 0 0 0 0 0 0 0 A0A8I3RVX5 A0A8I3RVX5_CANLF Cell cycle checkpoint control protein RAD9A Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231] checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737] LDDFASDDIDSYMIA 1 3.8 0.98713 -0.2283 0 0 0 9.35687 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RVX7 A0A8I3RVX7_CANLF Protein Wnt WNT7B Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182]; positive regulation of JNK cascade [GO:0046330]; tissue development [GO:0009888] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] ADGCDTMCCGRG;ARRLMNLHNNEAGRKV;GADGCDTMCCG;NCKFHWCCF;SPGADGCDTMCC 5 11.5 1.0036 -0.83027 0 8.54315 0 0 0 0 9.94975 0 0 0 0 0 9.69378 0 0 A0A8I3RVY8 A0A8I3RVY8_CANLF VWFA domain-containing protein ANTXRL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] signaling receptor activity [GO:0038023] EITNLEPSTF;GVPGPALLLLLVLP;WMDIYNLVED 3 6 0.99181 -0.55069 0 0 0 0 0 0 10.5064 0 0 5.74087 0 0 0 0 0 A0A8I3RVZ3 A0A8I3RVZ3_CANLF Leucine-rich repeat-containing protein 51 LRTOMT Canis lupus familiaris (Dog) (Canis familiaris) AWIDLSFNDLTSIDPVLTT;DLSFNDLTSIDPV;DPVLTTFFNLS;LTSIDPVL 4 15.5 1.0021 -0.65477 0 0 9.91362 0 0 0 0 0 0 0 0 5.02152 0 7.84637 9.79355 A0A8I3RVZ9 A0A8I3RVZ9_CANLF "Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial)" MRPL14 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] YCHPHYTGEESQEHQ 1 8.3 0.95217 0.053874 0 0 0 0 7.88765 0 0 0 0 0 0 0 0 0 0 A0A8I3RW13 A0A8I3RW13_CANLF Stromal cell derived factor 2 SDF2 Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] endoplasmic reticulum [GO:0005783]; protein folding chaperone complex [GO:0101031] misfolded protein binding [GO:0051787] VLRHFRLPVT 1 4.5 0.99985 -0.61146 0 0 0 0 0 0 0 6.45016 0 0 0 0 0 0 0 A0A8I3RW26 A0A8I3RW26_CANLF Rap guanine nucleotide exchange factor 6 RAPGEF6 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] HCRECKNFNS;IVVENSKDNEDSILQ;KESQLSMLQLSTIE;KKILQITR;LCSDEDAQELVKESQ;TLSRERLANSK;VEPSSKAADAGLKRGDQIMEVNGQ 7 6.7 1.0032 -1.9159 10.1834 14.4929 0 0 0 0 0 0 10.5753 0 8.81526 0 0 0 0 A0A8I3RW27 A0A8I3RW27_CANLF Potassium calcium-activated channel subfamily N member 2 KCNN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calmodulin binding [GO:0005516]; small conductance calcium-activated potassium channel activity [GO:0016286] EIQLFMVDNGADD;GGGGGGGG;GGGGGGSG;LSGSSCCCCC;NSCASSGAPAAGAGAGDNL;PCPPFASLPHPQHHPHLAHQQP;PQHHPHLAH;SGGGGGGA;SGSSCCCC;SSCCCCCS;TSSPLSGSSCCC;YNGGVMRPLSN 12 11.4 0.99667 -4.7528 0 9.50299 7.13597 0 9.69223 0 9.28561 0 0 7.38379 0 0 0 0 10.019 A0A8I3RW36 A0A8I3RW36_CANLF J domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082] GGGGGGGG;GGVGGGGG;SEARVVVLRLQWICVFCEA;SLQRELWR;VGGGGGGG;VGGGGGGGG 6 19.3 0.99054 -0.51201 0 0 0 0 0 0 8.76709 10.0642 0 0 0 0 0 0 0 A0A8I3RW55 A0A8I3RW55_CANLF PBX homeobox 3 PBX3 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; dorsal spinal cord development [GO:0021516]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; respiratory gaseous exchange by respiratory system [GO:0007585] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ALPPPPHGHEGADGDGRKQ;ASGGSSDNSIEHSDY;PNSGSSGS 3 9.7 1.0021 -1.363 0 0 0 0 0 0 10.1427 0 0 0 6.69418 0 0 0 0 A0A8I3RW61 A0A8I3RW61_CANLF Zinc finger CCCH-type containing 13 ZC3H13 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DRRDERARERDRERERDRERERERE;DTESQKRNTE;DTESQKRNTEE;ERERERERDREREKERELERERARE;ERERERERERARERDKERERQRDWE;ERERERERERDREREKERELERE;GPELPEKGSRG;KEREREREERERERERERERERERA;LVEISNGKNGTLED;RAREREREREREKERDRERERDR;RDERARERDRERERDRERERERERE;SPSHLTEDRQGRW;SSYPERDRYPERDNRDQARDSSFER;SVQGFEDISKAERTESVEG;VEISNGKNGTLEDSQK;YVHELSLE 16 12.5 0.98826 -0.34523 0 5.80426 10.3475 8.63448 0 0 13.7571 14.0785 8.42244 11.5515 12.3461 9.86702 10.6071 13.6807 9.74774 A0A8I3RW63 A0A8I3RW63_CANLF E3 UFM1-protein ligase 1 (E3 UFM1-protein transferase 1) UFL1 Canis lupus familiaris (Dog) (Canis familiaris) protein ufmylation [GO:0071569] UFM1 ligase activity [GO:0061666] SLNEKSIEDF 1 1.3 0.9852 -0.2413 0 0 0 0 0 0 0 0 0 0 0 8.96076 0 0 0 A0A8I3RW67 A0A8I3RW67_CANLF NADH:ubiquinone oxidoreductase complex assembly factor 8 NDUFAF8 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex I assembly [GO:0032981] mitochondrion [GO:0005739] AEAAAYGR 1 10.8 1.0044 -1.1044 0 0 7.17782 7.39283 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RW76 A0A8I3RW76_CANLF Mitochondrial translational initiation factor 2 MTIF2 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743] EFKVGDEIICYEE;HVDHGKTTLLD;IICYEEKEVPG;VHISAVTGDNLMALAE;VIKKTRMKLKWSKLK 5 9 0.98664 -0.3291 0 10.9659 0 0 0 0 0 5.06432 0 0 8.97307 0 0 10.5696 0 A0A8I3RW80 A0A8I3RW80_CANLF Regulator of G protein signaling 12 RGS12 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] GTPase activator activity [GO:0005096] AEAGGVQTLEGEH;ESIAKIGKKKYQ;FDSYTRFLKSQLYQECILAEVEGRS;FSIGPENPEDF;LADDILSAPHPD;LNELVARLSGEKEP;PADRYRVEGSLAQPP;QFVSVLYRDMGELIEGV;TSELPSLS;VEGRSLPDAQQVPSSPAS;VLQEWQCGHASD 11 10.7 1.0018 -0.96527 6.19503 11.3767 8.65492 0 10.4551 0 0 0 0 8.52293 4.33714 0 10.9318 6.62051 0 A0A8I3RW86 A0A8I3RW86_CANLF Cell adhesion molecule 4 CADM4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; regulation of cell motility [GO:2000145]; regulation of cell population proliferation [GO:0042127]; regulation of Rac protein signal transduction [GO:0035020]; regulation of wound healing [GO:0061041] cell leading edge [GO:0031252]; cell-cell contact zone [GO:0044291]; membrane [GO:0016020] protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184] EAQNQALPSGHSKQTQYVLDVQYS;LVSADNGTYTCEA;QAVEGGEVE 3 11.9 0.85174 0.14989 0 0 0 0 0 0 9.39345 0 0 0 0 0 7.30278 0 0 A0A8I3RW88 A0A8I3RW88_CANLF UBX domain protein 1 UBXN1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of ERAD pathway [GO:1904293]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein K48-linked deubiquitination [GO:1903094]; negative regulation of protein ubiquitination [GO:0031397] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098] ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; proteasome regulatory particle binding [GO:1904855]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625] CAFCCSYCGQEMS;QGIEAAMDWLMEHE 2 7.5 0.98659 -0.3929 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.80038 A0A8I3RWA0 A0A8I3RWA0_CANLF Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) MAFG Canis lupus familiaris (Dog) (Canis familiaris) adult behavior [GO:0030534]; in utero embryonic development [GO:0001701]; positive regulation of gene expression [GO:0010628]; regulation of cell population proliferation [GO:0042127]; regulation of epidermal cell differentiation [GO:0045604] RNA polymerase II transcription regulator complex [GO:0090575] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PARGPLAAGLGPLVPG;RRTLKNRGYAAS 2 17.3 0.95656 0.049233 0 0 0 0 0 0 0 0 0 0 3.83086 0 0 0 0 A0A8I3RWA8 A0A8I3RWA8_CANLF HMG-box containing 3 HMGXB3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EAEEEGEEEEVA;QECWLLTASRL;SSMGLPRARQPFPLSDKTPSV;TLVNGSPDLPSGSL 4 4.6 0.66 0.31913 12.5532 0 0 0 0 5.86545 0 0 9.40024 0 0 12.2448 0 0 0 A0A8I3RWB9 A0A8I3RWB9_CANLF "KH RNA binding domain containing, signal transduction associated 3" KHDRBS3 Canis lupus familiaris (Dog) (Canis familiaris) "cell differentiation [GO:0030154]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" nucleus [GO:0005634] mRNA binding [GO:0003729] GCSGQYPQCLEQC;GVGVPRGT 2 6.7 0.99192 -0.27023 0 0 0 0 0 0 10.314 0 0 0 0 0 0 0 0 A0A8I3RWC0 A0A8I3RWC0_CANLF Rho guanine nucleotide exchange factor 39 ARHGEF39 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] LKKNKRFRRFVRLQ;LPLQRLQQYENL;WHHSLTLAISSQK 3 11.6 0.86628 0.1788 0 0 6.35785 0 0 0 10.5886 0 0 8.9222 0 0 0 0 0 A0A8I3RWC2 A0A8I3RWC2_CANLF Peroxisomal biogenesis factor 11 beta PEX11B Canis lupus familiaris (Dog) (Canis familiaris) peroxisome fission [GO:0016559] peroxisomal membrane [GO:0005778] GTPGGGLPQLALKLQLRVLLL;HLSLGRKLLRLGN;QLALKLQLRVLLLARVLRGHPPLLL 3 18.8 0.87302 0.14273 0 0 0 5.08712 0 0 0 0 0 2.74898 0 0 0 0 8.44332 A0A8I3RWC4 A0A8I3RWC4_CANLF Splicing regulatory glutamic acid and lysine rich protein 1 SREK1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear speck [GO:0016607] RNA binding [GO:0003723] DHISERRERERSSSTRK;IDEKRKKD;PDNAPLAFS;RERERSSSTRKSS 4 5.8 0.99707 -0.59731 0 0 0 6.95652 0 0 0 0 0 0 0 9.14374 0 10.0282 0 A0A8I3RWE4 A0A8I3RWE4_CANLF Olfactory receptor OR5E1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VIQTVLTFQLSFCDS 1 4.8 0.87239 0.13405 0 0 6.86999 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RWE9 A0A8I3RWE9_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) NEK8 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of hippo signaling [GO:0035330] ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] RGAGGALGALARSHHPYLGQAPP;SLVPGPPM 2 4.3 0.9875 -0.46307 0 0 0 0 0 0 0 11.5814 0 0 0 0 0 0 0 A0A8I3RWF3 A0A8I3RWF3_CANLF Cysteine rich protein 3 CRIP3 Canis lupus familiaris (Dog) (Canis familiaris) HPRQWPKVWNVGLWGCVDNFP 1 9.9 0.9782 0.047716 3.35614 0 0 0 0 0 0 0 0 0 8.31985 0 0 0 0 A0A8I3RWF4 A0A8I3RWF4_CANLF Uncharacterized protein ASCL4 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] LPRLPPADP 1 5.1 0.99697 -0.11182 0 0 0 0 0 0 0 0 12.5215 0 0 0 0 12.7988 0 A0A8I3RWG4 A0A8I3RWG4_CANLF Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) NR2E1 Canis lupus familiaris (Dog) (Canis familiaris) aggressive behavior [GO:0002118]; amygdala development [GO:0021764]; angiogenesis [GO:0001525]; anterior commissure morphogenesis [GO:0021960]; apoptotic process [GO:0006915]; astrocyte cell migration [GO:0043615]; astrocyte differentiation [GO:0048708]; behavioral fear response [GO:0001662]; cell fate commitment [GO:0045165]; cerebral cortex neuron differentiation [GO:0021895]; dentate gyrus development [GO:0021542]; extracellular matrix organization [GO:0030198]; forebrain generation of neurons [GO:0021872]; layer formation in cerebral cortex [GO:0021819]; long-term synaptic potentiation [GO:0060291]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; neuroblast proliferation [GO:0007405]; olfactory bulb development [GO:0021772]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of dendrite morphogenesis [GO:0048814]; regulation of timing of neuron differentiation [GO:0060164]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic stem cell population maintenance [GO:0035019]; visual perception [GO:0007601] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" SISPSTIEEVFFKKTIGNVP 1 5.2 0.95677 0.050944 0 0 0 0 0 0 7.76547 0 0 0 0 0 0 0 0 A0A8I3RWH3 A0A8I3RWH3_CANLF NSA2 ribosome biogenesis factor LOC102151399 Canis lupus familiaris (Dog) (Canis familiaris) maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" AQGETEVLKVIRTGKRKKKAWKRM 1 13 0.97375 0.041303 0 0 0 0 0 4.51368 0 0 0 0 0 0 0 0 0 A0A8I3RWI1 A0A8I3RWI1_CANLF Zinc finger protein 462 ZNF462 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; positive regulation of transcription by RNA polymerase II [GO:0045944] membrane [GO:0016020]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEEDYYGS;DLETNSMLNDSSSD;DNEVEIEVELD;EAQEMEWLPFR;EVELDREEEPTE;GVCNGYQKKKKKKKKKKKKK;GVCNGYQKKKKKKKKKKKKKKKTK;HYQKRHDIDAYYTHCLAASRTI;KFCVRYFRSK;KKKKKKKK;KKKKKKKKKKK;KKKKKKKKKKKK;KKKKKKKKKKKKK;KKKKKKKKKKKKKK;KKKKKKKKKKKKKKK;KKKKKKKKKKT;KKKKKKKKKTKKKKKRKKE;KKKKKKTKKKKKRK;KKKKKKTKKKKKRKK;KKKKTKKKKK;KKKTKKKKKRKKERKKK;LLNTQTPIYGTE;MNRFQCPFCPF;PAEEVEDSNDSSYSEPPDVQQ;PLCLYHTKY;QKKKKKKK;QKKKKKKKKKKKKK;QKKKKKKKKKKKKKK;QKKKKKKKKKKKKKKKTK;QQEDAVINVEDDEEEEEDN;TKKKKKRKKERKKKEK;TPIYGTEHNNENTD;VGVLVHYQ;YCSFVSAFRHNLD;YQKKKKKKKKKKKKKK;YQKKKKKKKKKKKKKKK;YQKKKKKKKKKKKKKKKTKKKK;YTNPIRKGLAAHYQKRH 38 9.1 0.99695 -4.1124 9.80695 10.9016 7.19269 11.817 8.01909 6.98277 9.41583 11.168 0 9.86831 12.57 8.82836 11.1585 8.33472 7.09128 A0A8I3RWI6 A0A8I3RWI6_CANLF Kelch repeat and BTB domain-containing protein 8 KBTBD8 Canis lupus familiaris (Dog) (Canis familiaris) neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; protein monoubiquitination [GO:0006513]; regulation of translation [GO:0006417] Cul3-RING ubiquitin ligase complex [GO:0031463]; Golgi apparatus [GO:0005794]; spindle [GO:0005819] ENDFWMYD;HLFVRATQVTVEEHVFRT 2 4.3 1.0036 -1.0561 0 0 0 5.56529 0 0 9.08616 0 0 0 0 0 0 0 0 A0A8I3RWJ1 A0A8I3RWJ1_CANLF Glutamate metabotropic receptor 6 GRM6 Canis lupus familiaris (Dog) (Canis familiaris) detection of light stimulus involved in visual perception [GO:0050908]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; locomotory behavior [GO:0007626]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; retina development in camera-type eye [GO:0060041] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; protein homodimerization activity [GO:0042803] AGTPVMFNENGDAPGRYDIF;FVPIFFGTAQ;GVMAWLGAQPPHSVI;GVPCCWHCEPCDGYRF;NIWFAEFWEENFN 5 8.4 0.99796 -0.10407 0 0 0 0 6.75128 0 8.19328 4.66278 9.61625 0 0 0 0 5.37006 0 A0A8I3RWJ2 A0A8I3RWJ2_CANLF Post-GPI attachment to proteins 2 PGAP2 Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] VYFRHNMYCEAGVYTIFAILEYTV 1 9.4 0.97408 0.041303 0 0 0 0 0 0 0 0 8.58706 0 0 0 0 0 0 A0A8I3RWL1 A0A8I3RWL1_CANLF PCNA-interacting partner (PARP-1 binding protein) (PARP1-binding protein) PARPBP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair via homologous recombination [GO:2000042] cytoplasm [GO:0005737]; nucleus [GO:0005634] EDIKKTYDD;LARKIIYSYLN;RQYEVADETD;SIAGGRILSVIKMQLIKG 4 8.3 1.0041 -0.81054 0 0 0 0 0 0 12.8646 0 0 0 3.12345 0 0 0 0 A0A8I3RWL4 A0A8I3RWL4_CANLF Leucine rich repeats and immunoglobulin like domains 1 LRIG1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CGDCNTDSDGYSK;DEESLADLSSLSILRLSHNSISH;LLLLLLLL;LLLLLLLLL;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPLLLLLLLLLRP;PPPPLLLLLLLLL;RPVLPPPPPPLLLLLLLLLRPGS;SLVWVCIIYQTRKKS 12 6.7 0.98543 -0.43034 5.9232 0 3.36737 0 7.19564 0 0 0 0 0 0 0 0 0 10.2147 A0A8I3RWL5 A0A8I3RWL5_CANLF Delta like non-canonical Notch ligand 2 DLK2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Notch signaling pathway [GO:0045746]; regulation of fat cell differentiation [GO:0045598] membrane [GO:0016020] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802] YDGGGEYHCVCPPSFHGHDC 1 5.2 0.97276 0.048206 0 0 0 0 0 0 0 0 0 0 0 4.44407 0 0 0 A0A8I3RWM4 A0A8I3RWM4_CANLF Protein SREK1IP1 SREK1IP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] HHKKEKKKRKKEKHS;KIKLKKKRKR;SSTSSEESDEE 3 23.2 0.98919 -0.52209 0 0 0 1.0285 0 0 0 0 0 0 0 8.53776 0 7.19614 0 A0A8I3RWM5 A0A8I3RWM5_CANLF Myelin regulatory factor MYRF Canis lupus familiaris (Dog) (Canis familiaris) protein autoprocessing [GO:0016540] membrane [GO:0016020] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AKNSPSLSLHGRTRRGA;GIGHSKHPKSSEPLASPA;HFQVTVYIGMLGE;LVHYRYKPEF;RCHCPFTPCHDIN;SGPPIKAEPKAPYAPG;YPVLQRDLYMKAEP 7 9.4 0.94166 0.059618 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 A0A8I3RWN5 A0A8I3RWN5_CANLF Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GVHIHKKKKIRTSP;LKAKKAVLKGVHIHKKKKIR;VHIHKKKKIRTS;VLKGVHIHKKKKIRTSPTFRR 4 17.4 0.99172 -0.18305 0 0 0 0 0 0 0 2.93068 0 0 0 0 0 4.40524 4.27531 A0A8I3RWN8 A0A8I3RWN8_CANLF Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase (EC 2.4.1.135) B3GAT3 Canis lupus familiaris (Dog) (Canis familiaris) chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; positive regulation of intracellular protein transport [GO:0090316]; protein glycosylation [GO:0006486] cis-Golgi network [GO:0005801]; Golgi membrane [GO:0000139] galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; metal ion binding [GO:0046872]; protein phosphatase activator activity [GO:0072542] ELFEEMRWT;YSRELFEEMRWTRGVSVWPVGLVGG 2 7.5 0.99203 -0.5501 0 0 0 0 0 0 0 0 0 0 0 0 12.2012 0 0 A0A8I3RWP1 A0A8I3RWP1_CANLF Tachykinin precursor 4 TAC4 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of flagellated sperm motility [GO:1902093] extracellular space [GO:0005615] GLMGKRVGGMPPIQ;LGRVGPSPEGR 2 22.1 0.99193 -0.20805 0 10.7412 0 0 0 0 0 0 0 0 0 0 0 9.40797 0 A0A8I3RWP7 A0A8I3RWP7_CANLF X-ray repair cross complementing 2 XRCC2 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; mitotic cell cycle [GO:0000278]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; positive regulation of neurogenesis [GO:0050769]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756] centrosome [GO:0005813]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; four-way junction DNA binding [GO:0000400] FYWIDRVNGGESVNLQ;QVVKHRIFFSKQEDFKTN;TVVCSHPSLCL 3 16.1 0.98717 -0.37917 0 0 12.2221 0 0 0 0 0 7.03397 0 0 0 9.20122 0 0 A0A8I3RWQ3 A0A8I3RWQ3_CANLF Transforming acidic coiled-coil containing protein 1 TACC1 Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ALADLNSVE;GPEAKTQESQEVDEQL;GPEGDPEDEDSQAETKSL;GRKLGSKLPPKVQK;QRYQALKIHA;RKVGRKLGSKLPPKVQKDS;SKLRKPKPVPLRKKTI 7 11.4 1.0023 -0.73852 0 0 7.81493 0 0 0 0 0 4.95243 0 0 0 0 4.13947 8.97404 A0A8I3RWQ5 A0A8I3RWQ5_CANLF Distal-less homeobox 3 DLX3 Canis lupus familiaris (Dog) (Canis familiaris) blood vessel development [GO:0001568]; BMP signaling pathway [GO:0030509]; gene expression [GO:0010467]; hair cell differentiation [GO:0035315]; hair follicle cell proliferation [GO:0071335]; hair follicle morphogenesis [GO:0031069]; odontoblast differentiation [GO:0071895]; odontogenesis of dentin-containing tooth [GO:0042475]; placenta development [GO:0001890]; Wnt signaling pathway [GO:0016055] cytoplasm [GO:0005737]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PALWDTSSHSTPA;YRQYGAYREQPLPAQ 2 9.8 0.99205 -0.20747 10.2505 9.69098 0 0 0 0 9.74626 0 0 0 0 0 0 0 0 A0A8I3RWQ7 A0A8I3RWQ7_CANLF Transmembrane protein 151B TMEM151B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDEDDDEEEEAGPPP;EAGPPPPYHDAL;GGGGGGGG;GGGGGGPG;HYHVEKLFGLEGPG;LSLLIAYQGNSLMYHDSPC;LSSQASMGDDEDDDEEEEAG;PAREEQRPIQ;TVDSTELE 9 16.5 0.94949 0.049977 8.22004 0 0 0 0 0 0 0 7.66342 0 0 0 0 8.44344 0 A0A8I3RWQ8 A0A8I3RWQ8_CANLF RNA binding protein fox-1 homolog 2 RBFOX2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] GADLYGGYAAYRYAQ;YIPLIIPGFPYP 2 7.5 0.95236 0.053901 0 0 0 0 0 0 0 0 0 0 0 7.80697 0 0 0 A0A8I3RWS4 A0A8I3RWS4_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) SSH2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721] DLCKNCLSER;ELNLNDINGCSSGCC;EVARMHNYYPGSLFLTWVSYYESHI;FSVSTDNRVHI;NPSFMRQLEEY;PEDNIRLAVRLESTYQ;PLRRLKKA;RATLEFEERLRQEQE;SEGSYAAQ;SLHKACEVARMHN;WRSHSDSDLSD 11 9.8 0.99879 -2.9731 0 0 8.68092 0 0 0 0 0 0 10.9106 13.1583 8.11718 11.1388 0 8.48828 A0A8I3RWT1 A0A8I3RWT1_CANLF Uncharacterized protein AIG1 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] GCPAPGVL;NHGMHTTVLPFILIEM 2 10.2 1.0028 -1.3878 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4479 0 A0A8I3RWT4 A0A8I3RWT4_CANLF Molecule interacting with CasL protein 1 (EC 1.14.13.225) (EC 1.6.3.1) MICAL1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoskeleton [GO:0005856]; endosome membrane [GO:0010008]; midbody [GO:0030496] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] EHFTEEPPVPESGVPPTPPS;EKQWHLDQELRGYLNQEGALKTPAD;QEELLRWCR 3 5.5 0.98962 -0.19938 0 0 0 0 9.46371 0 0 0 10.901 10.6598 0 10.1389 0 0 0 A0A8I3RWT7 A0A8I3RWT7_CANLF Ring finger protein 38 RNF38 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleoplasm [GO:0005654] ubiquitin protein ligase activity [GO:0061630] ANSTPLPG;GAQAGGAC;PGQFVPFQTQ;QEVSFGVPYPPFMPRRL;QHLPVCSVPPPMLQ 5 9.1 0.98762 -0.23421 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1887 0 A0A8I3RWT8 A0A8I3RWT8_CANLF Ring finger protein 175 RNF175 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] CPYCKEKVDLKRMINNPWERTHFLY;GVVGYLAIMFTMCG;VGKKQTCPYCKEK;VVPLYFTIKLYWWRFL 4 20.3 0.86528 0.14575 0 8.88338 0 0 0 0 0 0 7.20398 5.20992 0 0 0 0 0 A0A8I3RWU0 A0A8I3RWU0_CANLF Nuclear transcription factor Y subunit gamma NFYC Canis lupus familiaris (Dog) (Canis familiaris) CCAAT-binding factor complex [GO:0016602] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DELKPPKRQEEVRQSVTPA;QEEVRQSVTPAEPVQYYFTLA;QLNAGQLQYIRLAQPVSGT 3 16.2 0.99347 -0.1746 0 0 8.87557 0 0 0 0 0 7.70155 0 0 0 0 0 0 A0A8I3RWU8 A0A8I3RWU8_CANLF TTK protein kinase TTK Canis lupus familiaris (Dog) (Canis familiaris) VCYIYRANGAWHL 1 16.7 0.99021 -0.26164 0 0 0 0 0 0 0 0 0 0 0 0 0 9.21449 0 A0A8I3RWV9 A0A8I3RWV9_CANLF ECRG4 augurin precursor ECRG4 Canis lupus familiaris (Dog) (Canis familiaris) anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular senescence [GO:0090398]; G1 to G0 transition [GO:0070314] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020] DITYWLNRDRNGHDYDYYQRHYDED 1 17.1 0.97903 0.035538 0 0 0 0 0 0 0 5.0408 0 0 0 0 0 5.56007 0 A0A8I3RWW5 A0A8I3RWW5_CANLF Follistatin like 4 FSTL4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] EEGLSVGNMFYV;PSDLLRFDDYNND;VTDSVVGPNGDV 3 4.4 0.58937 0.38854 0 0 0 9.52299 0 0 0 0 0 9.51613 12.4433 9.4476 9.28214 0 4.32135 A0A8I3RWX4 A0A8I3RWX4_CANLF Large ribosomal subunit protein uL2 (60S ribosomal protein L8) RPL8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic translation [GO:0002181] cytosolic large ribosomal subunit [GO:0022625]; organelle membrane [GO:0031090] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KKRTELFIAAEG 1 4.7 0.94561 0.05044 0 0 0 0 0 0 0 0 0 0 7.78901 0 0 0 0 A0A8I3RWY8 A0A8I3RWY8_CANLF Histone acetyltransferase (EC 2.3.1.48) KAT8 Canis lupus familiaris (Dog) (Canis familiaris) myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy [GO:0010506]; regulation of mRNA processing [GO:0050684]; transcription initiation-coupled chromatin remodeling [GO:0045815] kinetochore [GO:0000776]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; nuclear matrix [GO:0016363] enzyme binding [GO:0019899]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713] KQPKLWLCEYCLKYMKF;KYMKFEKS;LDHKTLYFDVEPFVFYIL 3 8.3 1.0027 -0.7192 9.45364 0 0 0 6.76845 0 0 0 0 0 0 0 0 0 0 A0A8I3RWZ6 A0A8I3RWZ6_CANLF C-X-C chemokine receptor type 6 CXCR6 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935]; inflammatory response [GO:0006954] membrane [GO:0016020] C-X-C chemokine receptor activity [GO:0016494]; coreceptor activity [GO:0015026] FHYAIIITEAIAYLR;LVIYLFYQKL 2 7.3 0.99092 -0.20568 0 0 9.87719 0 0 0 7.44029 0 0 0 0 0 0 0 0 A0A8I3RX08 A0A8I3RX08_CANLF Leucine zipper transcription factor-like protein 1 LZTFL1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; negative regulation of protein localization to ciliary membrane [GO:1903568]; spermatogenesis [GO:0007283] cilium [GO:0005929]; cytosol [GO:0005829]; manchette [GO:0002177] identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877] VEETFTVDEVSEV 1 4.3 0.99232 -0.14186 0 0 0 0 0 0 0 0 0 0 0 0 0 9.84604 0 A0A8I3RX09 A0A8I3RX09_CANLF Tetratricopeptide repeat protein 39B TTC39B Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] LEFIGFSGN;RIAGKSIP 2 2.8 1.0029 -0.85466 9.66183 0 0 0 0 0 0 0 0 8.77057 8.61633 0 0 0 9.19118 A0A8I3RX17 A0A8I3RX17_CANLF Transmembrane protein 79 TMEM79 Canis lupus familiaris (Dog) (Canis familiaris) cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055] lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588] identical protein binding [GO:0042802] AMLVWNLYYMFLVEPERM 1 4.6 0.97392 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 9.52211 0 0 A0A8I3RX20 A0A8I3RX20_CANLF "Papilin, proteoglycan like sulfated glycoprotein" PAPLN Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] CCPDGVSAAE;CQQSRYGCCPDGV;DMGGLGAI;GTSLDPHARWQ;PEVPSMQDVHTSPRDPW;STHGAGAGAGGGGGPGGRQEG;VGCDHNLDSSKEEDK 7 6.6 1.0029 -0.83928 9.59777 0 0 12.5364 13.0209 13.0254 0 0 0 0 0 6.07451 0 9.2567 0 A0A8I3RX22 A0A8I3RX22_CANLF Olfactory receptor OR2AT2B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERK1 and ERK2 cascade [GO:0070374] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LDFHIMGNV;PLDFHIMGNVAYA 2 4.1 0.99023 -0.26194 0 0 9.98584 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RX27 A0A8I3RX27_CANLF Coiled-coil domain containing 126 CCDC126 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] ELIESWSKLAEDEEYTILEK;HYTFQQPRHQ 2 13.6 0.98802 -0.22559 0 0 0 0 0 0 0 0 8.89966 0 0 0 0 0 6.77584 A0A8I3RX29 A0A8I3RX29_CANLF tRNA-dihydrouridine(47) synthase [NAD(P)(+)] (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3) DUS3L Canis lupus familiaris (Dog) (Canis familiaris) flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; tRNA dihydrouridine synthase activity [GO:0017150] AELGERPQV;EDVFGVQLEGAFP;IEVDFVDI;KRARGQNKGRPHM;NGLDRALQQQL 5 8.5 1.0018 -0.96119 0 0 0 0 0 7.90081 0 0 0 8.97739 0 0 0 0 10.3449 A0A8I3RX32 A0A8I3RX32_CANLF Transmembrane p24 trafficking protein 6 TMED6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] YEGPEMDHKQK 1 4.6 0.99041 -0.26734 0 0 0 0 0 0 0 0 0 0 0 0 8.81564 0 0 A0A8I3RX51 A0A8I3RX51_CANLF Cleavage and polyadenylation specific factor 7 CPSF7 Canis lupus familiaris (Dog) (Canis familiaris) mRNA alternative polyadenylation [GO:0110104] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] mRNA binding [GO:0003729] ASAGDYSDAIETLLTA;LVPSSARVDKPPSVLP;QIDLYDDVLTA 3 10.6 0.99081 -0.1461 0 0 8.99283 0 0 0 0 0 11.8307 0 0 0 9.55922 0 0 A0A8I3RX55 A0A8I3RX55_CANLF Progestin and adipoQ receptor family member 6 PAQR6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] LLVFLLPA;RRPTSSARDCV 2 5.5 1.0022 -1.3611 0 0 0 8.75952 0 0 0 0 0 0 0 0 0 8.40416 0 A0A8I3RX57 A0A8I3RX57_CANLF MICOS complex subunit Canis lupus familiaris (Dog) (Canis familiaris) cristae formation [GO:0042407] MICOS complex [GO:0061617] RFFFNYYYLRFYLFIHERQRERVQS;TVSGLAGL 2 14.3 0.98849 -0.22505 4.06281 3.10578 16.16 0 0 5.87659 0 0 0 0 0 16.1797 16.6919 0 0 A0A8I3RX58 A0A8I3RX58_CANLF Nucleolar pre-rRNA processing protein NIP7 NIP7 Canis lupus familiaris (Dog) (Canis familiaris) GENLQLLVDRPDGTYCFRLHNDR 1 17.3 0.974 0.046523 0 0 0 0 0 0 0 0 0 0 0 0 0 8.25833 0 A0A8I3RX63 A0A8I3RX63_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DIVMTQTPL;DIVMTQTPLS;DIVMTQTPLSL;DIVMTQTPLSLS;DIVMTQTPLSLSVS;DIVMTQTPLSLSVSP;DIVMTQTPLSLSVSPG;DIVMTQTPLSLSVSPGE;DIVMTQTPLSLSVSPGEPA;IVMTQTPLSL;PGVPDRFSG;PGVPDRFSGSG;PGVPDRFSGSGSG;PGVPDRFSGSGSGTDF;QSLLHSNGNTYLFWF 15 47.2 0 119.52 16.6825 16.8712 16.8287 14.3485 14.1542 14.3315 16.7693 16.7879 16.8813 16.9946 16.8908 16.9035 16.1739 16.3604 16.3873 A0A8I3RX64 A0A8I3RX64_CANLF Zinc finger protein 853 ZNF853 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DKAQPRQQELQLQQSEQQPEQQPQ;EVELELMPVDL;SGGSESQEEEEAQEKNSSPPPP 3 7.8 0.8542 0.15692 0 11.4255 0 0 0 0 0 0 7.1531 5.26941 0 0 11.3765 0 0 A0A8I3RX69 A0A8I3RX69_CANLF leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) LARS2 Canis lupus familiaris (Dog) (Canis familiaris) leucyl-tRNA aminoacylation [GO:0006429] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] FYVLSMFPYP;PALARVQK;QDALADLPEWY;RFRFRFGSRGFLRLEQ;RGMQVINPMGWDAFGL;SLKETLRKALVPGKDCLT 6 9.2 0.98931 -0.21643 0 0 0 0 6.46348 0 0 0 0 0 0 0 8.90406 0 0 A0A8I3RX70 A0A8I3RX70_CANLF "5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)" COQ7 Canis lupus familiaris (Dog) (Canis familiaris) ubiquinone biosynthetic process [GO:0006744] extrinsic component of mitochondrial inner membrane [GO:0031314] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]" SAFRAEDRWRTGKCRKMWDQEKD 1 9.1 0.97909 0.046276 0 0 0 0 7.62337 0 0 0 0 0 0 0 0 0 0 A0A8I3RX85 A0A8I3RX85_CANLF Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 12) CDK12 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; RNA splicing [GO:0008380] cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nuclear speck [GO:0016607] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] DLLDHMLTLD;IKSFMKQLMEGL;KVITLWYR;MAPEESLKEAPPA;PAGSLEENNSDKNSGP;QSSTRSPSPYSRRQ;SSISPVRLPLNSSLGAELSRK 7 6.7 1.0024 -0.66652 0 5.71474 0 0 0 0 0 0 9.40561 0 0 0 9.77294 9.44679 0 A0A8I3RX95 A0A8I3RX95_CANLF F-box protein 28 FBXO28 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] kinetochore [GO:0000776] identical protein binding [GO:0042802] EEGGGGHG;GGGHGDGG;IVPILKRKLP 3 5.7 1.0001 -2.8202 0 0 9.05064 0 0 3.82894 0 0 0 0 0 0 5.14539 6.78581 0 A0A8I3RXA4 A0A8I3RXA4_CANLF Junctional cadherin complex regulator JHY Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cerebrospinal fluid circulation [GO:0090660]; establishment of localization in cell [GO:0051649]; motile cilium assembly [GO:0044458]; regulation of establishment of planar polarity [GO:0090175] extracellular region [GO:0005576] ESPQQESLSETEEET;HLSQYESAKSNSVPRGQ;SLEEESPQQE;SQLNQIMEQHQQALIQ;TLSHVDLNYLH 5 8.1 0.98537 -0.44846 12.4522 0 12.8883 0 0 0 0 11.4858 0 0 6.93334 0 12.736 0 0 A0A8I3RXB3 A0A8I3RXB3_CANLF Leukocyte cell-derived chemotaxin 1 (Chondromodulin) CNMD Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; cell differentiation [GO:0030154] endomembrane system [GO:0012505]; extracellular region [GO:0005576] AIGAFYFWKG;YHQQEGESMTFDPRLD 2 7.8 0.99162 -0.54467 0 0 0 0 0 0 9.46856 0 0 0 0 0 0 13.7807 0 A0A8I3RXC0 A0A8I3RXC0_CANLF Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to nicotine [GO:0035095]; presynaptic modulation of chemical synaptic transmission [GO:0099171] acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] GVLGLGPSPLRLLLLLQLVAGRW;HEDSLFKDLFQD 2 7.4 0.9817 -0.24874 0 0 0 5.88294 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RXC3 A0A8I3RXC3_CANLF Schlafen family member 14 SLFN14 Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402]; platelet maturation [GO:0036345]; rRNA catabolic process [GO:0016075] cytoplasm [GO:0005737]; nucleus [GO:0005634] ribosome binding [GO:0043022]; RNA endonuclease activity [GO:0004521] KDYVTQQTTCQAVTRKI;VAERCHNLFQC;YVCMVQVEPFCCV 3 4.4 0.9852 -0.44019 0 0 0 0 0 0 0 0 0 0 0 0 10.2769 0 0 A0A8I3RXD6 A0A8I3RXD6_CANLF Coiled-coil-helix-coiled-coil-helix domain containing 2 CHCHD2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxidative stress [GO:0034599]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037] mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] DNA-binding transcription factor binding [GO:0140297]; sequence-specific DNA binding [GO:0043565] VGSPAAPRQPGLMAQMA 1 11.2 0.9856 0.046227 0 0 0 0 11.8829 0 0 0 0 0 0 0 0 0 0 A0A8I3RXE0 A0A8I3RXE0_CANLF Tetratricopeptide repeat protein 29 TTC29 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ARVRSLSWLQRP;DDDLSLGRAYEAI;EYKQAIRIL;GLLFEEEGQLLE;LCQIPENLEE;LDDDLSLGRAYEA;PENLEEELSGFPDN 7 13.7 0.99654 -0.5798 0 0 0 0 0 0 0 0 0 0 9.17478 0 0 0 0 A0A8I3RXE7 A0A8I3RXE7_CANLF Solute carrier family 30 member 6 SLC30A6 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion transport [GO:0006829] Golgi apparatus [GO:0005794]; membrane [GO:0016020] monoatomic cation transmembrane transporter activity [GO:0008324] FVALSFNLFTMLSVRNK;QLDKLIREVST;RPALLSGPV;SPVYSFGFERLEVLAVFA 4 12.7 0.99261 -0.16856 9.43746 7.36519 0 0 5.07733 0 0 0 0 0 0 0 0 0 0 A0A8I3RXF1 A0A8I3RXF1_CANLF Olfactory receptor OR13D3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVLLAVMAYDR;LIMTVASIVLLVLPLLLIFI;LLIFISYVFILSSILR 3 13.4 0.98857 -0.22395 0 0 9.70484 0 0 0 0 0 0 0 0 0 7.5074 0 0 A0A8I3RXF8 A0A8I3RXF8_CANLF F-box only protein 32 FBXO32 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] cytoplasm [GO:0005737]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005] SKTKTQYFHQEKWIYVHKGS;YFKLVRCYPRKEQ;YVHKGSTKERH 3 14.5 0.99103 -0.51435 0 0 0 0 8.54384 0 0 0 8.02791 0 0 0 0 0 0 A0A8I3RXH3 A0A8I3RXH3_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK6 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] LNEKQILEKVN;VGTVGYMAPEVV 2 4.1 0.98301 -0.25572 0 0 0 0 0 0 10.346 0 0 0 0 0 0 0 0 A0A8I3RXH8 A0A8I3RXH8_CANLF Uncharacterized protein GPR89A Canis lupus familiaris (Dog) (Canis familiaris) intracellular pH reduction [GO:0051452] Golgi cisterna membrane [GO:0032580]; monoatomic ion channel complex [GO:0034702] voltage-gated monoatomic anion channel activity [GO:0008308] FYIGYFIVSNIRL;SFILVGIIIVTSIRGLLITL 2 7.3 0.98584 -0.23239 0 0 0 0 0 0 0 0 0 0 0 0 0 8.13273 0 A0A8I3RXI3 A0A8I3RXI3_CANLF GH3 domain containing GHDC Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] EAVAAGNPGRAA;LLLLLLLL;LLLLLLLLGLLLPLASL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLGLLLPL;LLLLLLLLLLGLLLPLA;LLLLLLLLLLGLLLPLASLR;LLLLLLLLLLL;LLLLLLLLLLLGL;LLLLLLLLLLLGLLLPLASL;LLLLLLLLLLLL;LLLLLLLLLLLLGLLLP;LLLLLLLLLLLLGLLLPL;LLLLLLLLLLLLGLLLPLA;LLLLLLLLLLLLGLLLPLASLRQ;LLLLLLLLLLLLL;LLLLLLLLLLLLLGLLLPLA;LLLPLASLRQRQLQGARPS;MLLLLLLLLLLLLLGLL;MLLLLLLLLLLLLLGLLLP;MLLLLLLLLLLLLLGLLLPL;PWHALGQVSTPGAKHPGTLLQ 23 12.7 0.55376 0.42919 4.29719 6.52879 3.50779 5.5812 6.17523 7.31723 0 0 8.2529 0 9.06628 0 6.147 7.58391 9.46115 A0A8I3RXK2 A0A8I3RXK2_CANLF "Proteasome 26S subunit, non-ATPase 6" PSMD6 Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex [GO:0032991] LEDAEKNLGE;YYVREMRIHAYSQLLESY 2 7.7 0.99487 -0.56314 0 0 0 0 0 0 0 0 10.6308 0 0 0 0 10.165 0 A0A8I3RXK3 A0A8I3RXK3_CANLF Scratch family transcriptional repressor 1 SCRT1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of neuron migration [GO:2001222] nuclear body [GO:0016604] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FKGGAGGG;SGAGARGGARAGVSTE 2 6.9 0.96178 0.049233 0 7.68699 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RXL1 A0A8I3RXL1_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GGRGGGVGGNDSFGRGGN;GGSGDDCH;GGSGDDCHG;GNFSGRGGFGGSRGGGGYGGSGDDC;GYGGSGDD;SGSGNFGG 6 19.6 0.99899 -3.194 8.61835 5.80666 0 0 0 0 0 0 0 0 0 10.2439 7.072 5.2187 7.38172 A0A8I3RXL2 A0A8I3RXL2_CANLF Small ribosomal subunit protein mS39 PTCD3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] ribosomal small subunit binding [GO:0043024]; rRNA binding [GO:0019843] DVYTFNALIEATALNMNEKS;ELEEDTGENDKKSKKA;ESQDARQTAPD;FNALIEATALNMNEKSE;KERIKLKK 5 8.2 1.0017 -1.4128 0 0 0 5.23093 0 0 0 11.6016 4.85743 0 0 0 0 11.2632 0 A0A8I3RXL6 A0A8I3RXL6_CANLF Transmembrane protein 41B TMEM41B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] YFATYIFLQTFA 1 6.1 0.94595 0.05044 0 0 9.04502 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RXL9 A0A8I3RXL9_CANLF "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.35)" PDE6G Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]" VGLGPCAP 1 4.7 0.99052 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 7.16219 9.41867 A0A8I3RXM3 A0A8I3RXM3_CANLF Uncharacterized protein LOC111096978 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] DSPNKLCMLVTYVPV;VGFKKRAPRALKEIQK 2 24.8 0.991 -0.19519 0 0 0 0 0 0 9.43715 0 0 4.13414 0 0 0 0 0 A0A8I3RXN1 A0A8I3RXN1_CANLF Epithelial cell transforming 2 like ECT2L Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] RLYKQTCDLSL 1 1.2 0.98473 0.035491 0 0 0 0 0 0 0 0 0 0 8.74062 0 0 0 3.77136 A0A8I3RXN2 A0A8I3RXN2_CANLF Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (Prostaglandin H2 synthase 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 Canis lupus familiaris (Dog) (Canis familiaris) cyclooxygenase pathway [GO:0019371]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750] dioxygenase activity [GO:0051213]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666] AQFQYRNRIAMEFNQLYH;LTGEKEMAAELEELYGDI;LYHWHPLMPDSFWV;NSLRPSPS;RRFLLRRKFIPDPQG;SLLAGEGCGQEL;TDEGCFLARGRQRG 7 13.3 0.99008 -0.20483 0 0 0 7.09043 0 0 0 0 12.046 0 0 0 0 0 0 A0A8I3RXN5 A0A8I3RXN5_CANLF Transmembrane protein 268 TMEM268 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LAAANGALLRHRVLLGVTDT;VLLGVTDTVEGCQSVIQLWFVYFD;WFVYFDLEDCVQFLSEH 3 13.6 0.94167 0.087529 0 0 0 0 0 7.10171 0 0 0 0 0 0 0 7.35764 0 A0A8I3RXP8 A0A8I3RXP8_CANLF HYLS1 centriolar and ciliogenesis associated HYLS1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DESIISESESG;EERMLAAATAFTH;KASVTPGKRLALPVQLQYP;RWGVRCDLAN;VMKRKVLR 5 19.5 1.0024 -0.76329 9.67 0 0 0 0 0 0 0 11.5809 0 0 0 0 11.6529 12.4289 A0A8I3RXP9 A0A8I3RXP9_CANLF Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B PPP2R2A Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] ELTEVITAAEFHPN;SEIISSISDVK 2 5.6 0.94118 0.061082 0 0 0 0 0 0 9.52611 0 0 0 0 0 0 0 0 A0A8I3RXQ2 A0A8I3RXQ2_CANLF Zinc finger protein 689 ZNF689 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] KPFPCLECGRCFRQRWSLAVH 1 4.2 0.96531 0.04865 0 0 0 0 0 0 0 0 0 0 0 0 9.02633 0 0 A0A8I3RXQ4 A0A8I3RXQ4_CANLF Alpha-S1-casein CSN1S1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] LTQNELDSREPTPREL;VGAIHDQQQLRRVNENN 2 19.5 0.99444 -0.058985 0 0 0 0 0 0 9.05357 0 0 0 0 0 0 0 0 A0A8I3RXQ6 A0A8I3RXQ6_CANLF TBC1 domain family member 16 TBC1D16 Canis lupus familiaris (Dog) (Canis familiaris) regulation of receptor recycling [GO:0001919] cytosol [GO:0005829]; early endosome [GO:0005769] GTPase activator activity [GO:0005096] GAPNPLQV;LTPGGGGGPPSVLDGE;RWLLLCFKRE 3 4.1 1.0033 -1.5819 0 0 0 0 0 0 8.64447 9.3075 0 0 0 0 0 8.76168 0 A0A8I3RXR2 A0A8I3RXR2_CANLF Cation channel sperm associated 3 CATSPER3 Canis lupus familiaris (Dog) (Canis familiaris) establishment of localization in cell [GO:0051649]; flagellated sperm motility [GO:0030317]; sodium ion transport [GO:0006814]; sperm capacitation [GO:0048240] acrosomal vesicle [GO:0001669]; CatSper complex [GO:0036128]; endoplasmic reticulum [GO:0005783] voltage-gated calcium channel activity [GO:0005245] ASFVFLSMFVGV;IDVYLSTLDNQ;LDSRNLPLS;RQQEEVSKLMQ;VLWTDYNTKYNLF 5 14 1.0021 -0.68078 0 10.9582 0 7.59253 0 0 0 9.91718 0 0 0 0 0 0 0 A0A8I3RXR4 A0A8I3RXR4_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KB2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EVELTETSVNL;KKFLKRNPSQRIGG;LVKKFLKR 3 5.6 1.0019 -1.2322 0 4.37288 0 9.09666 0 0 5.05142 0 0 0 0 0 0 0 0 A0A8I3RXR6 A0A8I3RXR6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;RPRIARGILKKKTIIW 4 6.3 0.96299 0.049233 0 0 0 0 6.64616 0 0 0 0 0 0 0 0 0 0 A0A8I3RXS4 A0A8I3RXS4_CANLF tRNA methyltransferase 10 homolog B (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10B) TRMT10B Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] LAINQVFDILSTYF 1 6.3 0.98413 -0.24778 0 0 0 0 0 0 8.94848 0 0 0 0 0 0 0 0 A0A8I3RXT2 A0A8I3RXT2_CANLF LIM and SH3 domain protein 1 LASP1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925] actin filament binding [GO:0051015]; metal ion binding [GO:0046872] PSGKQMVSGPG 1 3.5 0.98156 0.035491 0 0 0 0 0 0 0 0 0 0 8.30401 0 0 0 0 A0A8I3RXU1 A0A8I3RXU1_CANLF CWC25 spliceosome associated protein homolog CWC25 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nuclear speck [GO:0016607]; U2-type catalytic step 1 spliceosome [GO:0071006] KKIKELLQMSLEKKEKKKKKEKKKK;PSGANSLLDMASK 2 9 0.99156 -0.18249 0 10.0391 0 0 0 0 0 0 5.35861 0 0 0 0 0 0 A0A8I3RXU6 A0A8I3RXU6_CANLF Phosphatidylinositol-5-phosphate 4-kinase type 2 beta PIP4K2B Canis lupus familiaris (Dog) (Canis familiaris) "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of autophagosome assembly [GO:2000786]" autophagosome [GO:0005776]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; protein homodimerization activity [GO:0042803] DEECENDGLGGN;EQEEMEVEERAE;MSSNCTSTTAVAV 3 8.9 0.99251 -0.19367 0 0 0 0 0 4.97099 0 3.61306 0 0 0 0 0 0 0 A0A8I3RXU8 A0A8I3RXU8_CANLF MAD2L1 binding protein MAD2L1BP Canis lupus familiaris (Dog) (Canis familiaris) deactivation of mitotic spindle assembly checkpoint [GO:1902426]; regulation of exit from mitosis [GO:0007096] cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AAEMSSRKCQQALAELESVLSHLEG;EETHAPQIELLETTSTQEPP 2 16.4 0.97893 0.035538 6.83378 0 0 0 0 0 6.47159 0 0 0 0 0 0 0 0 A0A8I3RXV3 A0A8I3RXV3_CANLF Proteasome subunit beta PSMB3 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] "cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex, beta-subunit complex [GO:0019774]" GVIVHIIEK 1 4.4 0.99187 -0.27195 0 0 0 0 0 0 0 0 0 0 0 7.63096 0 0 0 A0A8I3RXV4 A0A8I3RXV4_CANLF WD repeat domain 38 WDR38 Canis lupus familiaris (Dog) (Canis familiaris) SIWDLRMATPVIFHQELE;VGTVSFSPDSTQLAS 2 11.3 0.99419 -0.17377 0 0 0 0 0 0 0 10.2563 0 0 0 0 0 0 0 A0A8I3RXW1 A0A8I3RXW1_CANLF Zinc finger protein 771 ZNF771 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEEEEEMQEEM 1 3.5 0.98158 0.035491 0 0 0 0 0 0 0 0 0 0 7.82693 0 0 0 0 A0A8I3RXW3 A0A8I3RXW3_CANLF Sarcoglycan zeta SGCZ Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] AVFGHSVETPHIRAEPSQ 1 6.8 0.97095 0.048313 0 0 0 0 0 0 6.44869 0 0 0 0 0 0 0 0 A0A8I3RXW5 A0A8I3RXW5_CANLF "Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2" LAMTOR2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to amino acid stimulus [GO:0071230]; fibroblast migration [GO:0010761]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to cell junction [GO:1902414]; regulation of cell growth [GO:0001558]; regulation of cell-substrate junction organization [GO:0150116] FNIP-folliculin RagC/D GAP [GO:1990877]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Ragulator complex [GO:0071986] guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090] GMLKAKAAYGPDFSSPLAG;TAAIASNIWAAYDRN 2 22.8 0.98675 -0.33136 0 0 0 0 0 0 0 0 0 0 0 0 10.2674 8.84731 0 A0A8I3RXX3 A0A8I3RXX3_CANLF NDUFA4 mitochondrial complex associated like 2 NDUFA4L2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex IV [GO:0005751] PNDQYKFLAVSTD 1 14.9 0.93594 0.09711 0 0 0 11.2791 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RXX9 A0A8I3RXX9_CANLF Fibulin 7 FBLN7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] LLLLLAGPASRAS;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PASRASQNCFNKQQL;PGRPRALLLLLLLLLLA;RALLLLLLLLLL;RALLLLLLLLLLA;RHLPKTISFHYLSLPSNL;RPRALLLLLLLLLL;VPGRPRALLLLLLLLLLA 11 16.9 0.94319 0.10158 0 7.72792 0 3.48104 4.28251 0 3.74728 0 7.44178 0 0 0 0 6.73647 0 A0A8I3RXY4 A0A8I3RXY4_CANLF Small ribosomal subunit protein uS10 (40S ribosomal protein S20) LOC106559752 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic ribosome [GO:0022626]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] CGEGSKTW;TPVEPEVVIH 2 18.2 1.0033 -0.87466 0 0 0 9.1702 0 6.99831 0 0 0 0 0 0 0 0 0 A0A8I3RXZ0 A0A8I3RXZ0_CANLF Chromosome 17 open reading frame 113 C17orf113 Canis lupus familiaris (Dog) (Canis familiaris) FLGSVELQEGEATAAQ 1 2.4 0.98995 -0.21961 0 0 0 0 0 0 0 0 0 0 0 0 0 8.75318 0 A0A8I3RXZ7 A0A8I3RXZ7_CANLF TNF receptor superfamily member 21 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] membrane [GO:0016020] ALRTVEPSPLG;ESEPLLRCDSTS;HPEHMESHEVPSSTYVPKG;PIFDDMLHILNPEEL;RLDPCDLQPI 5 11.3 0.98137 0.035491 0 0 0 0 0 0 0 0 0 8.11998 0 0 0 0 0 A0A8I3RY01 A0A8I3RY01_CANLF "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1" ST8SIA1 Canis lupus familiaris (Dog) (Canis familiaris) N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]" EFLYSFTI;NSPMGKSMW 2 5.2 1.0025 -1.3558 5.63633 5.88352 0 0 0 10.3703 4.93291 0 0 0 0 5.29337 11.2221 0 10.4717 A0A8I3RY05 A0A8I3RY05_CANLF Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) DUSP3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893] cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654] cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor tyrosine kinase binding [GO:0030971] GCYSLPSQPCNEVTPRI;IPKLQKLGITHVL 2 16.2 0.93274 0.10579 0 0 0 0 7.23812 9.27065 0 0 0 0 0 0 0 0 0 A0A8I3RY06 A0A8I3RY06_CANLF Fast skeletal myosin light chain 2 MYL11 Canis lupus familiaris (Dog) (Canis familiaris) muscle contraction [GO:0006936]; skeletal muscle tissue development [GO:0007519] calcium ion binding [GO:0005509]; structural constituent of muscle [GO:0008307] YVITHGDAKDQ 1 6.5 0.98096 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.83042 A0A8I3RY08 A0A8I3RY08_CANLF Uncharacterized protein EVI2B Canis lupus familiaris (Dog) (Canis familiaris) myeloid cell development [GO:0061515]; negative regulation of apoptotic process [GO:0043066]; positive regulation of neutrophil differentiation [GO:0045660]; regulation of cell cycle [GO:0051726]; regulation of stem cell division [GO:2000035] IIIILLWKCLRKPV;SLDCLNQVCEDHNSEF 2 6.6 0.91512 0.11 0 0 0 0 0 0 0 0 0 0 0 0 9.66167 0 0 A0A8I3RY20 A0A8I3RY20_CANLF Uncharacterized protein HMX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" DEEDDDDDPEDED;EDDDDDPE;EDDDDDPEDEDA;EDEEDDDDDPEDEDAE;EDEEDDDDDPEDEDAEQ 5 4.9 1.0026 -0.89893 0 4.53717 0 0 6.82222 0 6.98687 0 0 0 0 3.47703 5.34014 0 0 A0A8I3RY21 A0A8I3RY21_CANLF WD repeat-containing protein 18 WDR18 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] dynein axonemal particle [GO:0120293]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AAQLGKNYISA;AEQLHAVMSSTMEKSVL;EPSHLERAEQLH 3 8.1 0.88672 0.13216 7.35509 0 0 0 0 0 0 0 0 8.69397 0 5.52525 0 6.90328 9.33002 A0A8I3RY22 A0A8I3RY22_CANLF Polo like kinase 5 (inactive) PLK5 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LPTAACAPG;SDPDPMEWGSEATL;TAACAPGGV 3 8.2 1.0023 -1.0029 0 10.2011 0 0 0 9.05539 10.9286 10.9929 0 0 7.94994 0 0 0 0 A0A8I3RY50 A0A8I3RY50_CANLF ADAM metallopeptidase domain 33 ADAM33 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AGDAHGNC;EECDCGASQECQDACCLAHNCSL;EEGEECDCGASQECQD;EEGEECDCGASQECQDACCLAH;EQCQQLWGPGS;GACPTLEEQCQQLWGPGS;GEECDCGASQECQDACC;GVCNSNKNCHCAPGWA;GVPCRRAVGDCDLP;IVNSAGDA;IVNSAGDAHGNCGQD;LVEEGEECDCGASQECQ;LVEEGEECDCGASQECQD;PDIYLLDGSPCASGRG;QDGKGGFVPCAQRD;VGGGGGSL;VPCAQRDAQ 17 13.4 0.98449 -0.25761 0 10.7698 0 0 0 0 0 0 9.33255 0 10.4666 0 0 0 0 A0A8I3RY51 A0A8I3RY51_CANLF Transmembrane protein 183A TMEM183A Canis lupus familiaris (Dog) (Canis familiaris) regulation of protein stability [GO:0031647] membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005] GVGEPCDVIDSSDEMD;LVFQDSPVHGGRKLRSEQ;NPDQDCCL 3 11.2 1.0029 -1.0068 0 0 0 0 0 8.53029 0 9.95862 0 0 0 0 0 0 0 A0A8I3RY55 A0A8I3RY55_CANLF Uncharacterized protein CEACAM18 Canis lupus familiaris (Dog) (Canis familiaris) ALYCEIDTIMEIP;LVSSNDRMTISPDL 2 7.2 0.99211 -0.18094 0 0 0 0 0 6.45983 0 0 0 0 0 0 0 0 0 A0A8I3RY60 A0A8I3RY60_CANLF Non-SMC condensin II complex subunit G2 NCAPG2 Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; inner cell mass cell proliferation [GO:0001833]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]; transcription by RNA polymerase II [GO:0006366] condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796] bHLH transcription factor binding [GO:0043425] EVQGEDIMETEHE;ILARLESDSRP;ISQEEQHTFASTVVHL;LDELKVCV;NELLDELSRKQKEE;PIRDPNFNAI;VLSYFHHQKKV 7 7.1 0.98252 -0.25039 0 0 0 0 0 0 0 0 0 0 0 0 0 9.57363 0 A0A8I3RY64 A0A8I3RY64_CANLF ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) ABCC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AGWPLQGEVE;CGKSSLVSALLGEMEKLE;ESCTVLTIAH;ESCTVLTIAHR;GQRQLVCLARALLRKSRILVLDEA;LVLHQYFHCIFEMAL;VGRTGAGKSSMTLC;WWFTKMAILGYRRPLEEQDL 8 7.6 1.0025 -1.1462 0 5.76107 0 0 0 5.35258 10.3838 8.09255 11.6727 4.86785 0 0 0 0 0 A0A8I3RY70 A0A8I3RY70_CANLF Protein Wnt WNT11 Canis lupus familiaris (Dog) (Canis familiaris) adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; atrial septum development [GO:0003283]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial cell apoptotic process [GO:1904019]; epithelial to mesenchymal transition [GO:0001837]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesenchymal cell proliferation [GO:0010463]; mesonephric duct development [GO:0072177]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of stem cell proliferation [GO:2000647]; neuroendocrine cell differentiation [GO:0061101]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transforming growth factor beta2 production [GO:0032915]; primary heart field specification [GO:0003138]; protein localization to cell surface [GO:0034394]; secondary heart field specification [GO:0003139]; secondary palate development [GO:0062009]; somite development [GO:0061053]; stem cell proliferation [GO:0072089]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295] LEMKCKCHGVSGSCSIRT;LLFALALQTGVCYGIKWLALS;PVPGEPPG;QCNKTSHGSDSCDLMCCG;QCNKTSHGSDSCDLMCCGRGYNPY;SHGSDSCDLMCC;VVERCHCKYHWCC 7 23.7 1.003 -0.97674 0 0 9.76646 0 0 0 0 14.7192 3.93904 0 8.82283 0 0 14.2597 0 A0A8I3RY74 A0A8I3RY74_CANLF CDK5 regulatory subunit-associated protein 2 CDK5RAP2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815] calmodulin binding [GO:0005516] AAEGDTLRFTNQ;AIITVLCGTEGGQD;DVLSKPKGSA;EGFQEQLNQCAGL;GELGHLAHVD;QMIRSLRGS;VAPHAEGV 7 4.3 1.0039 -1.1044 0 7.92119 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RY76 A0A8I3RY76_CANLF Glucosaminyl (N-acetyl) transferase 1 GCNT1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte tethering or rolling [GO:1903238]; tissue morphogenesis [GO:0048729] Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]" DLNCMQDLHRM;TKYYCLLLVF 2 4.9 0.98713 -0.22823 0 0 0 0 0 0 0 0 0 0 0 9.30741 0 0 12.5025 A0A8I3RY86 A0A8I3RY86_CANLF RAB GTPase activating protein 1 like RABGAP1L Canis lupus familiaris (Dog) (Canis familiaris) GVPCPAPA;LLLTKQRLVETEE;YRAEENARRLMEQAC 3 9.7 0.99052 -0.26592 0 0 0 0 0 9.53277 0 0 0 0 0 0 0 0 0 A0A8I3RY98 A0A8I3RY98_CANLF Host cell factor C2 HCFC2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] histone methyltransferase complex [GO:0035097] transcription coactivator activity [GO:0003713] DLWQLDLETMSWSKPE;DLWYLDTEKPP;GMCGARLDDLWQL;SKETPSNPVATMKAG;TSPHDCEWRCTSSFSY 5 8.4 0.98762 -0.36906 0 0 0 0 0 9.59963 0 3.77758 10.84 0 0 0 0 0 0 A0A8I3RYA2 A0A8I3RYA2_CANLF Uncharacterized protein PROX2 Canis lupus familiaris (Dog) (Canis familiaris) cell development [GO:0048468]; nervous system development [GO:0007399] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QMEKFARQAISDGVTNPK;VLRNSELY 2 7.1 1.0022 -0.76615 0 0 0 0 9.82574 0 0 0 0 0 0 0 0 0 0 A0A8I3RYA5 A0A8I3RYA5_CANLF EGF domain specific O-linked N-acetylglucosamine transferase EOGT Canis lupus familiaris (Dog) (Canis familiaris) glycosyltransferase activity [GO:0016757] DLARLRGVHYITWRRQ;GVNMYHHFCDF;HPTLGEHP;IEKPTYFMKLDAGVNMY;KLLVLGVLLH;TLEVQIVDYKY;VGLKVAMLKLLVLGVLL 7 15.4 0.98395 0.046227 0 0 0 0 0 0 0 0 5.32416 0 0 0 0 0 0 A0A8I3RYB0 A0A8I3RYB0_CANLF NAC-A/B domain-containing protein NACAD Canis lupus familiaris (Dog) (Canis familiaris) nascent polypeptide-associated complex [GO:0005854] AGGGGWGG;APAGDTHA;EAPGHLEPAT;EAPGHLEPATE;GEAPGGES;GGGGGGGG;GSVADEQELPYTGPPGP;GVQPAQCPAQAPAAG;MEAPEHLEPA;PGPRTAPAGDTHAK;QQADQDSPEEDSP;SSPSCSLSLLAPAEGLDVP;VIAKPDVFKSPASDTYVVFGE 13 6 1.0038 -1.1044 4.45009 0 0 0 0 0 0 0 0 0 0 0 0 0 7.63241 A0A8I3RYC5 A0A8I3RYC5_CANLF UPAR/Ly6 domain-containing protein LY6H Canis lupus familiaris (Dog) (Canis familiaris) APPPPAGT;PSDTVCASVRITD;TDPSSSRK 3 6.2 0.98662 -0.45057 0 0 0 8.55029 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYC8 A0A8I3RYC8_CANLF Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) AFMID Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; tryptophan catabolic process to kynurenine [GO:0019441] cytosol [GO:0005829]; nucleus [GO:0005634] arylformamidase activity [GO:0004061] GSKDTSAFMVNPLTEQ;LRQGGWNASFEEIHDMDHFEIIWN;PILFDLATHR;RQGGWNASFEEIHDMDHFEII 4 16.1 0.98798 -0.47036 0 0 0 0 0 0 7.31841 12.9 6.09704 0 0 0 0 3.74093 0 A0A8I3RYC9 A0A8I3RYC9_CANLF KH-type splicing regulatory protein KHSRP Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634] mRNA binding [GO:0003729] GVRIQFKQ;KQLIEEKIEGPLCPVGPGPG;PAGGGGGA;PPGAPPHAGGPPPHQYPPQ;QPPGGGGP;RGGGGPGG 6 10 1.0031 -1.5317 0 0 10.7127 5.93218 0 0 0 0 9.76954 0 0 0 11.4942 10.4497 0 A0A8I3RYD0 A0A8I3RYD0_CANLF Single stranded DNA binding protein 3 SSBP3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] single-stranded DNA binding [GO:0003697] YSSSSPGT 1 2.2 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.3579 A0A8I3RYD8 A0A8I3RYD8_CANLF Uncharacterized protein OTULIN Canis lupus familiaris (Dog) (Canis familiaris) protein linear deubiquitination [GO:1990108] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] LFARDTSNDPGQ 1 3.4 0.99255 -0.043241 0 0 0 0 0 0 0 0 0 0 0 13.2828 0 0 0 A0A8I3RYE9 A0A8I3RYE9_CANLF Divergent protein kinase domain 1A DIPK1A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] GPACNSLC;LYFGKCLSTKPN 2 5.4 1.0041 -1.0539 11.5946 10.784 0 0 0 0 11.2779 0 0 0 0 0 0 0 0 A0A8I3RYF1 A0A8I3RYF1_CANLF Tensin 3 TNS3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] CQGRGEGTGKEPAVGG;GVDPVYER;GVGPTPHLPDAQRPPPG;LDPQDRKWI;VIFCALDP 5 3.7 0.9589 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 8.84317 0 0 A0A8I3RYF2 A0A8I3RYF2_CANLF Otogelin OTOG Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; L-arabinose metabolic process [GO:0046373]; sensory perception of sound [GO:0007605] cytosol [GO:0005829]; extracellular matrix [GO:0031012] alpha-L-arabinofuranosidase activity [GO:0046556]; structural molecule activity [GO:0005198] CCPSYSCECDP;DSCCPSYSCECDPDLCEAE;DSCCTSYFCACGDCPDPI;DVTWFYSNCLTDTCGCSRGGDC;GDCECFCASVSAYAHQCCQHGVAVD;HPCASTCTAYGDRHY;LCVPRNQCSCHFQGMDYPPGDSD;LDEVTQRCVYLE;LGHCHCKDGV;LQVDQRWADDTVG;LVLRLYEHT;NKALGKGP;PFLCSSDSIYQACVA;PPDTYLDT;PRFGEVALLLPTEDP;PSLGHCHC;PVTCGAGG;QEDSCCPSYSC;RTFSACHRFVPPESFCELWIR;SCSVLTGELFAPCSAYLSP;SGSPSPESFLDEK;SLHPCASTCTAY;SPGEAEVL;TSYFCACGDC;VIFDDDSG;VLDSLAMSSWERR;VPACALSCEATKEYSPCVALCG;VTASNLPAHPTEPPA;WIRDTKYVQQPCVALTV 29 12.2 0.98467 -0.25713 0 0 0 0 0 0 0 0 0 0 0 8.13304 0 0 0 A0A8I3RYF4 A0A8I3RYF4_CANLF Centrosomal protein POC5 (Protein of centriole 5) POC5 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; cytoplasm [GO:0005737] SISSHADVHEIV;SPPMSSVVVEKHHPVT;SSPVSSPRKPS 3 7.1 0.98664 -0.32917 0 9.12397 0 0 0 11.1906 0 9.34669 0 0 0 0 0 0 0 A0A8I3RYG6 A0A8I3RYG6_CANLF Transmembrane protein 218 TMEM218 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; membrane [GO:0016020] EVEMKIVDSFFIG;LGVGAGVF 2 18.3 0.98811 -0.47627 0 0 10.4088 0 0 0 0 9.45411 0 0 0 0 0 0 0 A0A8I3RYH9 A0A8I3RYH9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VVSTTDTQHGHSR 1 10.2 0.94456 0.059647 0 0 4.3454 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYI4 A0A8I3RYI4_CANLF Alkaline ceramidase (EC 3.5.1.-) ACER1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; ceramide catabolic process [GO:0046514]; keratinocyte differentiation [GO:0030216]; regulation of lipid metabolic process [GO:0019216]; response to alkaline pH [GO:0010446]; sebaceous gland development [GO:0048733]; sphingosine biosynthetic process [GO:0046512] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] dihydroceramidase activity [GO:0071633] GQLLDEIAILWLLASS;IVFQEYKKTSN;VINAYALNSIAVHI;WMPRCYFPTFLGENRPHFIC 4 23.2 0.81473 0.20097 0 0 9.19237 7.72076 8.13689 0 0 0 0 0 5.38505 0 0 0 0 A0A8I3RYJ1 A0A8I3RYJ1_CANLF Protein arginine N-methyltransferase (EC 2.1.1.321) PRMT7 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; methylation [GO:0032259]; spliceosomal snRNP assembly [GO:0000387] cytosol [GO:0005829]; nucleus [GO:0005634] histone H4R3 methyltransferase activity [GO:0044020]; protein-arginine omega-N monomethyltransferase activity [GO:0035241] EEDEHYDYHQ;GVYPARPVCDCQAHLL;HDDYCVWYSLQRTSAEKNG;HYDYHQEIA;TVGYTVEF 5 8.7 1.0018 -0.71125 0 12.5104 0 0 13.0177 13.0339 0 13.2813 5.8201 12.7808 12.9601 12.9027 13.1776 13.2106 13.094 A0A8I3RYJ3 A0A8I3RYJ3_CANLF Protein misato homolog 1 MSTO1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion distribution [GO:0048311] cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741] CDYLQGFQ;LEDRLHFYLEECDYLQGF;VRSSAHLLLAPCQ 3 5.6 0.98735 -0.40355 0 7.74059 0 7.57297 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYJ8 A0A8I3RYJ8_CANLF Lysine demethylase 2A KDM2A Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; histone demethylase activity [GO:0032452]; metal ion binding [GO:0046872]; transcription coregulator activity [GO:0003712] GLGKTCRSLPSLKKTLSG;HNLELYENWLLSGK;HTNKYNANF;ISDDEIEGKRTF;LGGEEEEEEEEEEEDDSAEE;LLNEELPNCWECP;LTPPPHSPTSMLQL;NGDEEAVDREP;QCSPRKDRQ;SLEFSHTRLENM;VFRYLSRRELCECMRVCKTWYKW;YTFVIPSG 12 15.2 1.0037 -1.0663 0 0 0 0 9.55286 0 0 7.09761 9.93748 10.5524 7.48776 9.08218 10.8379 9.15368 0 A0A8I3RYL3 A0A8I3RYL3_CANLF DNA 3'-5' helicase (EC 5.6.2.4) RECQL4 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; telomeric D-loop disassembly [GO:0061820] "chromosome, telomeric region [GO:0000781]; nucleoplasm [GO:0005654]" ATP binding [GO:0005524]; bubble DNA binding [GO:0000405]; DNA/DNA annealing activity [GO:1990814]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; oxidized purine DNA binding [GO:0032357]; telomeric D-loop binding [GO:0061821]; zinc ion binding [GO:0008270] GVAEELVLRGP;LEADLGLLPRPCPRAAAP;LSGYFEEEEEEG;PSCGPCLEQ;VGPAEDCP;VGPAEDCPGEP;VPFQRGAGRPETLE 7 6 1.0021 -0.90555 0 8.10889 0 0 6.3109 8.43179 9.5708 8.27389 8.24831 0 8.03386 0 12.6275 0 7.95385 A0A8I3RYL8 A0A8I3RYL8_CANLF Elongin-A RPL11 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367] elongin complex [GO:0070449] DEADMDDEFEQP;DEADMDDEFEQPTMSF;GAAPPGPRVPAHAAAE;RCHRISPV;TMSFESYLSYDQPRKKKKKM;VGSFARDLVAQW 6 6.9 0.99382 -0.074596 0 8.38392 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYM0 A0A8I3RYM0_CANLF Myb/SANT DNA binding domain containing 7 MSANTD7 Canis lupus familiaris (Dog) (Canis familiaris) DLEDSWDESSGAGCSQ;EDTAWAKHCDQNL;VEEATGAFQLGL 3 11.4 0.98801 -0.49272 0 0 0 0 0 0 0 4.24732 0 0 9.25974 9.86422 0 0 3.37393 A0A8I3RYM7 A0A8I3RYM7_CANLF D(3) dopamine receptor (Dopamine D3 receptor) DRD3 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195] plasma membrane [GO:0005886]; synapse [GO:0045202] dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled receptor activity [GO:0004930] FGVTVLVYARIYVVLRQRRRKRIL;GVTVLVYARIYVVLRQRRRKRILT;LLFGFNTTGDPTVCSISNP;RPSFPQQPLSP 4 15 0.98449 -0.23924 0 9.62626 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYN5 A0A8I3RYN5_CANLF Ribonucleoside-diphosphate reductase (EC 1.17.4.1) RRM1 Canis lupus familiaris (Dog) (Canis familiaris) 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; DNA repair [GO:0006281]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185] mitochondrion [GO:0005739]; ribonucleoside-diphosphate reductase complex [GO:0005971] "ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]" DLFFALWI;DWSLMCPNECPGLDEVWG;EKLYESYE;GALEASCD;MRYPFESPEAQLLNK;TAAMVCSLENR 6 8.6 0.99736 -3.5055 0 7.95809 3.92818 9.33807 9.26458 0 0 9.63381 8.29893 0 7.59909 0 0 0 0 A0A8I3RYN9 A0A8I3RYN9_CANLF Actin-like protein 7B ACTL7B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] KAKARKVRRIKALVI;LKAKARKVRRIKALV;LLRLLNESGHAFTDDHL;RKVRRIKALVIDLGSQYCKCGYAGE 4 11.4 0.85921 0.18951 0 0 0 0 0 8.02531 4.26025 3.31136 0 0 0 5.95729 0 0 0 A0A8I3RYP5 A0A8I3RYP5_CANLF GTP-binding protein 10 GTPBP10 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EIPVPVGISVTDENGKVIGE;FTRGGTGGMGYPRL 2 9.8 0.99436 -0.16387 0 0 0 0 9.05162 0 0 0 0 9.53204 0 0 0 0 0 A0A8I3RYQ2 A0A8I3RYQ2_CANLF Kallikrein related peptidase 8 KLK8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CFRPKHEEFQVPTT;SLPSLDPESRS 2 5.5 0.8514 0.16568 0 0 0 0 0 0 9.1949 0 0 0 0 0 0 0 0 A0A8I3RYQ4 A0A8I3RYQ4_CANLF Vir like m6A methyltransferase associated VIRMA Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleus [GO:0005634] DTMGCCGDDS;DVEEEEDEDEDDRHTVDSIPEEEE;EEEDDEEEEGEEDEEGEGD;EEEEDEDEDDRHTVD;EEGEDDEDDVDVEEEEDEDED;EVEEEQQEEGEDDE;GEVEEEQQEEGEDDEDDVD;INLLEEVFHLM;IPEEEEDDEEEEG;NSDTMGCCGDD;SELLPLPL;SSGDPLPL;TPFQAEEID;VISHDRDSPPPPPPP;VVTAGSAI 15 7.5 0.99903 -3.0654 12.0385 11.8716 12.1803 0 7.289 11.4728 16.128 11.0495 11.2494 0 16.2058 16.1797 12.2326 11.465 11.4581 A0A8I3RYS9 A0A8I3RYS9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AGAWGAPCSVAASGAPS;ASAAWASPFFSP 2 16.6 0.99571 -0.013222 0 0 11.554 0 0 0 0 0 0 0 0 0 0 8.17278 0 A0A8I3RYT1 A0A8I3RYT1_CANLF Ceramide transfer protein (Collagen type IV alpha-3-binding protein) CERT1 Canis lupus familiaris (Dog) (Canis familiaris) ER to Golgi ceramide transport [GO:0035621] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794] lipid binding [GO:0008289] HRFVQKVEEMVQN;NTLSYYKSEDETEY 2 4.8 0.91638 0.12045 0 0 0 0 7.32112 0 0 0 6.49606 0 0 0 0 0 0 A0A8I3RYT2 A0A8I3RYT2_CANLF G1/S-specific cyclin-D1 CCND1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear membrane [GO:0031965] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] LPRRGERRPRAICISM;PPPARSHSLPRFDLC;QEQIEALLESSLRQAQQQ 3 10.2 0.98786 -0.45997 10.4245 0 0 0 0 0 7.17742 0 0 0 0 0 0 0 0 A0A8I3RYT8 A0A8I3RYT8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CTRKCSRALRCSN 1 15.1 0.93888 0.059775 0 0 0 0 0 0 0 0 0 0 0 0 0 12.2139 0 A0A8I3RYU3 A0A8I3RYU3_CANLF Olfactory receptor OR51R1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CLHCDLVGLACSDTQIN 1 5.4 0.99091 -0.21009 0 0 0 0 0 0 0 0 0 0 8.49077 0 0 0 0 A0A8I3RYU5 A0A8I3RYU5_CANLF Lysocardiolipin acyltransferase 1 LCLAT1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] HRRWEEKEERLRSFYQGEKN;LEKICLKASLKSVPGFGW;LWCHRRWEEKEERLRSFYQGEK 3 10.9 0.86711 0.14358 0 0 0 8.35861 0 0 0 0 0 5.79252 0 0 0 8.5806 0 A0A8I3RYV0 A0A8I3RYV0_CANLF Rho GTPase-activating protein 29 (Rho-type GTPase-activating protein 29) ARHGAP29 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] metal ion binding [GO:0046872] GNVNSDKFCRNL;KKWPSTCIEINRI;LIKSKDLLRQLPVSNFNSLHYL;LKLYLRQLPEPFILF;QDIVVCSTGGV;SISSNSIFDPD 6 6.9 0.98176 -0.24931 0 9.89473 9.40914 9.53658 0 0 0 6.28878 0 0 0 9.2688 0 0 0 A0A8I3RYV2 A0A8I3RYV2_CANLF glycerophosphocholine cholinephosphodiesterase (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) ENPP6 Canis lupus familiaris (Dog) (Canis familiaris) choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042] extracellular region [GO:0005576]; plasma membrane [GO:0005886] glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889] IPSRFYYKKGKFVS;MWDPNTNKSFDI;PLWVTLTKAKRKV;VIIFSDHGMTDIFWMDK;VVSLWPAPGKHSEV 5 15.9 0.9876 -0.40334 0 10.8718 0 0 0 0 0 7.41642 0 0 0 9.66231 8.68513 0 0 A0A8I3RYV4 A0A8I3RYV4_CANLF Gap junction protein GJB5 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154]; labyrinthine layer morphogenesis [GO:0060713]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707] connexin complex [GO:0005922] VLMHVAYREAQ;VLMHVAYREAQEK;YTLPRVVKC 3 8.1 0.98564 -0.43475 0 0 0 15.0978 8.47042 0 0 0 0 0 0 0 0 0 0 A0A8I3RYV7 A0A8I3RYV7_CANLF Collagen type IV alpha 4 chain COL4A4 Canis lupus familiaris (Dog) (Canis familiaris) collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; glomerular basement membrane development [GO:0032836] collagen type IV trimer [GO:0005587]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] APVVALHS;DLGLPGWIGEKGHPGPPGAEG;EAGCPGAP;EPGLTGAPGHPGRPG;GDCGPPGP;GFDGPPGP;PPGHQGFPGCD;VPGLTGPPG 8 5.6 1.0037 -2.2333 0 10.9615 0 0 8.68853 0 10.1785 6.69014 11.1056 0 0 0 9.06816 9.25399 11.0464 A0A8I3RYW2 A0A8I3RYW2_CANLF Bone morphogenetic protein 5 BMP5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] DLGWQDWIIAPEGYAAFYCDGECS;LVHLMFPDHV;RFENETIKISI 3 9.9 0.98442 -0.24014 9.55974 0 0 0 0 0 0 0 0 0 0 0 0 7.81935 0 A0A8I3RYW4 A0A8I3RYW4_CANLF Dynein axonemal heavy chain 14 DNAH14 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cilium [GO:0005929]; cytoplasm [GO:0005737]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AILIKNGLQWPL;DAVTLEELEEKMLNV;DEEIMAEEVRI;DENEDMCSPVNFP;DITNLSKEPKLESEK;DRRCLNTLLYKYCN;DSQVVEKVQVLVKQDEEIMA;DTRTLCLANSERITL;DVKYGSILGEVLLYNEI;EIEYNPRFRLYVATEI;EIVDILRKSKMTSN;ETLKHKTF;FIDDLNVPESDTYGTQPP;FITMSPTGP;FLAPNRLE;FPRFYFLSNAELLDILA;HSKVSVKFKNTKKS;HYYITPSSYLQFMDTFAHILRSR;ILILPDFNPNKIALVSVAC;KSQGISIDALTFTHHVTS;LFNNSARMPFSMEKRN;NIYELASKQLSQQAHY;NVLSLNYQSECLPYVETVI;PWEKLTPFQRLILIKILR;RLILIKILRP;RLQELSIKDSSYIQ;SETDETLIIIE;SLAHKAKMYSSYQNCFEEIQ;SLIEVMAQKHEV;TPFQRLILIKILRP;TVTFQGLQ;TWAKMAYTAI;YVSQGDASFMYGY 33 9.9 0.99736 -3.4312 0 9.65562 11.2207 5.46744 0 9.02608 10.6616 13.1447 13.1601 6.53319 6.99797 9.95207 9.88991 10.9416 0 A0A8I3RYW6 A0A8I3RYW6_CANLF WAP four-disulfide core domain 3 WFDC3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] peptidase inhibitor activity [GO:0030414] GPEAGRRCGPRGGGF;VPVPKPKLE 2 10.8 1.0016 -0.96266 0 0 9.47903 8.59347 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RYY1 A0A8I3RYY1_CANLF Transcription factor 15 TCF15 Canis lupus familiaris (Dog) (Canis familiaris) ear development [GO:0043583]; establishment of epithelial cell apical/basal polarity [GO:0045198]; mesenchymal to epithelial transition [GO:0060231]; muscle organ morphogenesis [GO:0048644]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; neuromuscular process controlling posture [GO:0050884]; paraxial mesoderm development [GO:0048339]; positive regulation of stem cell differentiation [GO:2000738]; post-anal tail morphogenesis [GO:0036342]; regulation of extracellular matrix organization [GO:1903053]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell population maintenance [GO:0019827] RNA polymerase II transcription regulator complex [GO:0090575] "bHLH transcription factor binding [GO:0043425]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" ENRSESDASDQSFGCCEG;GGGGGGGA;LASSYIAHLA;VVVVRQRQAANARER 4 25.2 0.99312 -0.16271 0 0 0 0 0 10.8481 0 0 8.44576 0 0 0 0 0 0 A0A8I3RYY4 A0A8I3RYY4_CANLF Tripartite motif-containing protein 72 (Mitsugumin-53) TRIM72 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383] zinc ion binding [GO:0008270] GIYLSFGDGVLSFY;GSLDREAERVRGEAG;HLDPLSIYCE;LSCPLCLQL 4 10.1 0.98651 -0.45567 9.42997 8.53644 0 0 0 0 0 0 9.3524 0 0 0 0 0 0 A0A8I3RYZ2 A0A8I3RYZ2_CANLF Sp6 transcription factor SP6 Canis lupus familiaris (Dog) (Canis familiaris) epithelial to mesenchymal transition [GO:0001837]; odontogenesis [GO:0042476]; regulation of odontogenesis [GO:0042481] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AGDYPSPLQ;DAPHASPPRLDLQPL 2 6.4 0.67541 0.27786 0 9.21018 0 0 0 0 0 0 0 0 0 0 0 0 5.05515 A0A8I3RYZ7 A0A8I3RYZ7_CANLF Dentin matrix acidic phosphoprotein 1 DMP1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of enamel mineralization [GO:0070173] cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; nucleus [GO:0005634] extracellular matrix binding [GO:0050840] CFLIEETVKK;DKDDDEDDSGDDTFGDDDNGPG;ESQSEQDSQSEE;GDGSEFGDEEMQND;GDGSEFGDEEMQNDDP;NSKETGLSQ;QEVDLPSQENSSESQEE;SASAESQSEESQSEQDSQSEE;SEESQSEQDSQSEEDDASDSQ;SQSEESQSEQDSQSEEDDASD;VSSEEQANEDSSDSAESEDSLDD;VSSEEQANEDSSDSAESEDSLDDH 12 21.9 1.0023 -1.2203 4.48549 5.83656 6.11699 0 0 0 12.0854 5.71598 11.2917 0 8.22848 14.8404 0 5.639 7.86555 A0A8I3RZ05 A0A8I3RZ05_CANLF Translocase of outer mitochondrial membrane 6 TOMM6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane translocase complex [GO:0005742] GVGVSAAGAPNEAPEIPDNVGDWL 1 32.4 0.97128 0.041303 0 0 0 0 0 0 0 0 7.5588 0 0 0 0 0 0 A0A8I3RZ12 A0A8I3RZ12_CANLF Integrin-binding sialoprotein (Bone sialoprotein 2) (Bone sialoprotein II) (Cell-binding sialoprotein) IBSP Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; ossification [GO:0001503] extracellular region [GO:0005576] ATKEEESDEEEEEEDEE;DEYSYYKGHSYDSYDGQ;EEEYEQTGTNEYDNGYEVYESEN;ESDEEEEEEDEENEENEA;ETSNEEENNEENANSDENEDESD;KGHSYDSYDGQDYYY 6 30.5 0.69858 0.28715 5.41082 9.81354 0 0 7.48462 0 0 0 0 5.08508 0 0 0 3.639 0 A0A8I3RZ16 A0A8I3RZ16_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FEEGFKIN 1 8.5 0.9939 -0.16356 0 0 0 0 0 0 0 0 0 0 8.61633 0 0 0 0 A0A8I3RZ18 A0A8I3RZ18_CANLF pyridoxal 5'-phosphate synthase (EC 1.4.3.5) PNPO Canis lupus familiaris (Dog) (Canis familiaris) pyridoxamine metabolic process [GO:0042818]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829] FMN binding [GO:0010181]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; pyridoxamine phosphate oxidase activity [GO:0004733] GVVMDLGP;LVFYWEPLNRQVRVEG;PSARMVLLKGFG 3 13.8 1.0023 -1.1863 0 5.08878 0 0 11.2883 0 0 0 0 7.25663 0 0 0 0 0 A0A8I3RZ19 A0A8I3RZ19_CANLF Large ribosomal subunit protein uL1m MRPL1 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934]; mitochondrion [GO:0005739] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] LNPLKKKLKKR 1 3.4 0.98135 0.035491 0 0 0 0 0 0 0 0 7.61243 0 0 0 0 0 0 A0A8I3RZ21 A0A8I3RZ21_CANLF RALY RNA binding protein like RALYL Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; RNA binding [GO:0003723] VGCSVHKGYAFVQ;VGGYVFDYDYYREDFYNRLFDYHG 2 12.1 0.97288 0.041303 0 0 0 0 0 0 0 7.21684 0 0 0 0 0 8.74709 8.61184 A0A8I3RZ26 A0A8I3RZ26_CANLF Uncharacterized protein SPECC1 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure formation involved in morphogenesis [GO:0048646] cytoplasm [GO:0005737]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; microfilament motor activity [GO:0000146] ASSGMKSSKSSTSLAFESR;SVTVSRERTVPRGPSNPR 2 4.7 0.99046 -0.19585 0 0 0 0 8.87064 0 0 0 10.1737 0 0 0 0 0 0 A0A8I3RZ27 A0A8I3RZ27_CANLF Meiotic double-stranded break formation protein 1 MEI1 Canis lupus familiaris (Dog) (Canis familiaris) EALLDYLHARSPD;FLRTALQQSFSSAF;IPEFLFEHLSSSSEVLVWSSYNCLI;LPLVLKKLLLS;SPADVDIL 5 5.6 1.0027 -1.1831 0 0 0 0 0 8.04281 7.9735 0 0 4.94205 0 5.59509 0 0 10.127 A0A8I3RZ30 A0A8I3RZ30_CANLF Transcription factor JunB (Transcription factor AP-1 subunit JunB) JUNB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; decidualization [GO:0046697]; embryonic process involved in female pregnancy [GO:0060136]; labyrinthine layer blood vessel development [GO:0060716]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; positive regulation of cell differentiation [GO:0045597]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; trophectodermal cell differentiation [GO:0001829]; vasculogenesis [GO:0001570] nucleoplasm [GO:0005654]; transcription factor AP-1 complex [GO:0035976] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EARSRDATPP;FYPRGGGSGGGAGGAGGGV 2 8.4 1.0035 -0.8352 0 0 11.4784 0 0 0 0 0 0 9.29687 0 0 0 0 0 A0A8I3RZ37 A0A8I3RZ37_CANLF CUB and Sushi multiple domains 2 CSMD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DFHLLLQVYQ;EISCVKIEN;FPEPYLNSLNCVWKIMVPEGA;GFQTVSSKVNATMID;GRPVNTAREPPLTQASVPGDV;GVQQGSTFNL;LHFYSDISVS;QAFALEED;SAGLYGNFTAQVRF;SEMTGVTLNSTSSSLWL;SHACGNPG;SLFLAFRSDASVSSAGFVIDYTENP;SLPAVLTCEGNGSWT;TWDRPRPQ;VHCPTNELL;VTVPKDYVVFGQ;VVFSDGLGFASSVV;YALQGHAH;YQLSLPAVLTCEGN 19 7.1 0.99658 -4.8414 6.75275 3.61718 10.4156 0 9.61099 0 9.35039 11.4691 13.8557 10.6758 8.60441 0 8.58173 9.64169 10.239 A0A8I3RZ40 A0A8I3RZ40_CANLF Zinc finger protein 517 ZNF517 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872] LSTSLGVLEDKQRASGR 1 3.6 0.53409 0.45241 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9443 A0A8I3RZ45 A0A8I3RZ45_CANLF Uncharacterized protein LOC102153485 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] QKNYTTGGQRE 1 2.8 0.98417 -0.24198 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16.2773 A0A8I3RZ49 A0A8I3RZ49_CANLF Tectonin beta-propeller repeat containing 2 TECPR2 Canis lupus familiaris (Dog) (Canis familiaris) APGSETRLRGSSVASSVASEP;DAVQQVAVSPSG;DTINQATIAGLEGSGD;EESCPTDDGPSSGQSPCQ;EFHVAKGN;ETSVTELGGSRSLQDLSQ;FIRTLSKSCPTGMHW;KVKKRRKKKT;LAVSEKYIWCLDYK;LVVKPLKVKKRR;LVVKPLKVKKRRKK;LVVKPLKVKKRRKKKT;LYPRLESSNRGSCSLPE;NFEGKTEPITV;SQRFSVISSEDFD;TESPDQDSNLSGEVN 16 15.1 1.0035 -2.0489 8.33579 12.6834 11.3753 12.129 12.1788 0 13.3299 14.2896 0 6.07223 0 10.1513 10.7807 0 12.1104 A0A8I3RZ53 A0A8I3RZ53_CANLF Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) CDK14 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] AAEPGYSAFLGTP;AAFPGMKDIQ;GVGCIFVEMI;GVGCIFVEMIQ;NEDTWPGV;VHTDLCQYMDKHPGG 6 12.6 1.0013 -0.70442 19.5317 0 0 0 10.9816 0 0 5.525 10.3664 0 0 0 0 20.2441 0 A0A8I3RZ56 A0A8I3RZ56_CANLF DUF4283 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IMLNEVSQSFP 1 12.4 0.99312 -0.04916 0 0 0 0 0 0 0 0 0 0 13.9255 0 0 0 0 A0A8I3RZ58 A0A8I3RZ58_CANLF Bestrophin BEST2 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; plasma membrane [GO:0005886] bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly ligand-gated monoatomic ion channel activity [GO:0005217]; ligand-gated monoatomic cation channel activity [GO:0099094] EAGFMTREERKKFENLNSSYNKY;ETSTATSCAC;LAKEDMQFQRLDGVDGPLG 3 10.2 1.004 -0.80706 0 0 10.8616 9.90167 10.0658 0 0 10.6302 9.19064 11.2143 0 0 10.9448 10.874 10.6381 A0A8I3RZ59 A0A8I3RZ59_CANLF Megakaryocyte and platelet inhibitory receptor G6b MPIG6B Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; integrin-mediated signaling pathway [GO:0007229]; megakaryocyte development [GO:0035855]; platelet formation [GO:0030220] plasma membrane [GO:0005886] FCRGRHEEESRTVLH;GLSKGRRPILW;KVDSQRPVKEEEP;VLQLLLLL 4 21.9 0.98492 -0.44548 5.98846 0 0 0 0 0 0 0 0 0 7.4297 0 0 9.61283 0 A0A8I3RZ70 A0A8I3RZ70_CANLF Methyl-CpG binding domain protein 6 MBD6 Canis lupus familiaris (Dog) (Canis familiaris) chromocenter [GO:0010369]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] chromatin binding [GO:0003682] AEGGVEPKDPSPP;GAPAPPAA;GDGGGGGG;GGDGGGGG;GGGDGGGG;GGGGDGGG;GGGGGDGG;GGGGGGDGGG;GGGGGGGD;GGGGGGGG;GPACPLPPLAGGEAF;GPLGGAPTVEGPGAPPFLASSL;PGSPDRLWLWKGP;PLACLLQSLQIPP;PSGTELSSLE;TDPGASSLGKAPSNSGRPPQ 16 11.5 1.0032 -2.0811 12.7478 10.6612 0 9.33929 0 6.11815 9.84762 0 0 0 12.8172 12.8047 8.28919 0 0 A0A8I3RZ75 A0A8I3RZ75_CANLF MD-2-related lipid-recognition domain-containing protein LY86 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] YQSCDPLQ 1 5 1.0044 -1.1044 0 0 0 0 0 0 0 0 7.91988 0 0 0 0 0 0 A0A8I3RZA2 A0A8I3RZA2_CANLF "N-alpha-acetyltransferase 16, NatA auxiliary subunit" NAA16 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HNATSLQHL;KWMDEAQSLDTADRF;LEHIETYEKQ;YYEGLEKALQLSEKF 4 6.1 0.95019 0.053889 0 8.09476 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZA3 A0A8I3RZA3_CANLF Adenylate kinase 8 (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8) AK8 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane-bounded organelle [GO:0043227] (d)CMP kinase activity [GO:0004127]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] EQIKLKLDLFYRNF;LDGIPATREQALMIQTI;LDPVTGERYHLM 3 9.8 0.84912 0.15761 6.26371 0 0 0 5.73852 0 0 0 0 0 0 0 7.01279 0 8.96417 A0A8I3RZB3 A0A8I3RZB3_CANLF DEAD-box helicase 56 DDX56 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] DVSAAEDSASQRAVLMEK;KKRKKLASKKVKKAKTQNPL;LVRPHKKRK;LVRPHKKRKKLASKKVKK;LVRPHKKRKKLASKKVKKAK;LYFHIGETEKRCFIEEIPDETMVI 6 9.1 1.0026 -0.89564 4.85624 0 0 0 9.13265 0 8.3082 0 0 7.81903 0 0 4.55145 0 11.1883 A0A8I3RZC3 A0A8I3RZC3_CANLF Fas associated factor family member 2 FAF2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] ubiquitin binding [GO:0043130] DHRIYSYVVSRPQP;LTFIMDANQTYLV;MLFWACSTNKP;TVIHDFLFSLKESPE;VLRQQQDE 5 13.9 1.0025 -0.84217 0 0 0 0 8.48901 0 11.1186 0 0 9.81444 0 0 0 8.49265 0 A0A8I3RZC5 A0A8I3RZC5_CANLF "ATP synthase subunit d, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] YPYYPHKPIEN 1 6.9 0.98367 0.035491 0 0 0 0 0 8.47013 0 0 0 0 0 0 0 0 0 A0A8I3RZD9 A0A8I3RZD9_CANLF ADRM1 26S proteasome ubiquitin receptor ADRM1 Canis lupus familiaris (Dog) (Canis familiaris) proteasome assembly [GO:0043248]; transcription elongation by RNA polymerase II [GO:0006368] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502] endopeptidase activator activity [GO:0061133]; protease binding [GO:0002020]; proteasome binding [GO:0070628] ARSEQEGDGKDKKDEEE;GSGGHELSALGGEG;VSAPPPPTHTHTKAE 3 8.9 0.93965 0.070092 0 0 0 0 0 0 0 0 0 0 9.78465 0 0 0 0 A0A8I3RZE2 A0A8I3RZE2_CANLF DNA-directed RNA polymerase III subunit POLR3G Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; transcription by RNA polymerase III [GO:0006383] RNA polymerase III complex [GO:0005666] DDDAAEQEEYDEEEQE;NSYFEDGDDFGADSDDN;NSYFEDGDDFGADSDDNMDE;QEEYDEEEQEEENDYINSYFEDGDD;YDEEEQEEENDYINSYFEDGDDF 5 18.8 0.7878 0.22546 0 0 0 0 0 0 4.11453 0 6.94883 3.60774 6.28324 0 0 0 0 A0A8I3RZF0 A0A8I3RZF0_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD3 Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179] cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PVTYCEPA;SLVKKLKK 2 4.1 0.98914 -0.2632 0 0 0 0 0 0 0 0 0 0 0 7.81461 0 0 0 A0A8I3RZF2 A0A8I3RZF2_CANLF TATA-box binding protein associated factor 9 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] nucleus [GO:0005634] protein heterodimerization activity [GO:0046982] EEEEEEEEEEEEEEEEEEEEEEEE;EEEEEEEEEEEGEGEGEGEGEED;LPPDRYCLTAPNYRFK 3 18.8 0.92748 0.095486 0 0 0 0 0 0 0 9.38005 0 0 0 0 8.34407 0 0 A0A8I3RZG9 A0A8I3RZG9_CANLF "Complex I assembly factor TIMMDC1, mitochondrial (Translocase of inner mitochondrial membrane domain-containing protein 1)" TIMMDC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESGWDRLRDLF;GDQELPDYAESGWD;GFLCGRLSPFPRVFAAGAV;GWAYGGIPAF 4 17.6 0.99445 -0.15903 0 0 0 0 0 0 8.24403 0 0 0 7.72322 0 5.82952 0 0 A0A8I3RZH7 A0A8I3RZH7_CANLF Protein Wnt WNT8B Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; neuron differentiation [GO:0030182] extracellular space [GO:0005615] cytokine activity [GO:0005125]; frizzled binding [GO:0005109] CSLGDFDNCGCDDSRNGQ 1 5.1 0.97344 0.048313 9.04974 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZI6 A0A8I3RZI6_CANLF Deoxyhypusine synthase DHPS Canis lupus familiaris (Dog) (Canis familiaris) glucose homeostasis [GO:0042593]; positive regulation of T cell proliferation [GO:0042102]; spermidine metabolic process [GO:0008216] deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802] DATLVFPLLVAETF;LEQNTEGVKW 2 6.5 1.0022 -0.90264 0 0 0 0 0 0 0 0 5.83673 0 0 0 0 0 0 A0A8I3RZI9 A0A8I3RZI9_CANLF Tax1 binding protein 1 TAX1BP1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; protein localization to phagocytic vesicle [GO:1905161] autophagosome [GO:0005776]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407] kinase binding [GO:0019900]; metal ion binding [GO:0046872]; protein-macromolecule adaptor activity [GO:0030674] ALCGPGLIAVRLL;EQVQATRQE;LDGNKESMITHFKEEIGRLQ;LLVVHLLLV;PGLIAVRLLVVHLLLVVL;QEVPLQTSNFAHVI;VEELLTMEDEGN 7 8.4 1.0044 -2.0142 0 0 0 5.72244 0 0 0 9.62275 12.0945 10.7181 0 0 9.99181 0 10.5236 A0A8I3RZJ1 A0A8I3RZJ1_CANLF Mitochondrial translation release factor 1 MTRF1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] translation release factor activity [GO:0003747] LNKNYPRRYC;PLAAIYQEIQ;VPKEKYDK 3 6.9 1.0031 -0.97458 8.77324 0 8.80558 10.3722 9.68893 0 0 0 9.91355 9.93157 9.49729 11.1918 0 0 0 A0A8I3RZJ4 A0A8I3RZJ4_CANLF UBX domain protein 11 UBXN11 Canis lupus familiaris (Dog) (Canis familiaris) FEIFSTFPPTV;KQPGVWCVIPQQGDMRG;QVYPENGLDPFPGEGRVVG;SDLRNQVYPENG 4 10.2 0.98748 -0.47769 5.95659 6.61254 0 0 0 0 0 0 0 0 4.56084 0 9.36315 0 9.77982 A0A8I3RZJ7 A0A8I3RZJ7_CANLF Proline rich 22 PRR22 Canis lupus familiaris (Dog) (Canis familiaris) HGPSEPLAFPSKELHG;LDEEPPPRPGP;PALPDSRGGGDDSSSD;PHYQPAPGGPQYFLPYFPPE;VGSSNLYQP 5 16.5 1.0021 -0.66349 10.3704 12.6492 0 0 0 0 0 0 0 0 0 0 11.0296 5.07686 0 A0A8I3RZJ9 A0A8I3RZJ9_CANLF Uncharacterized protein LOC102155374 Canis lupus familiaris (Dog) (Canis familiaris) ASQNKVAILKMKLRSQFTRAEEA;GDTPASPVP;LEAHIIRFRVRHKWDLPS;PNRAEWIPGRDSRWEG 4 4.6 1.0017 -0.9625 0 0 0 0 0 0 0 7.49297 0 0 6.29559 6.5658 0 0 0 A0A8I3RZL6 A0A8I3RZL6_CANLF Protein amnionless AMN Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] plasma membrane [GO:0005886] LLLLLLALAAGLLLLR;LLLLLLALAAGLLLLRRAPRL;PRMWGRLPLE;SRAGLAGGV;VPTTDFEAAANWSQNRTPCA;YKLWVPTTDF 6 10 1.0021 -1.8825 0 0 0 0 0 8.05848 10.5064 5.53085 0 0 0 0 7.42777 9.77793 0 A0A8I3RZL8 A0A8I3RZL8_CANLF U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) PRPF3 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal tri-snRNP complex assembly [GO:0000244] Cajal body [GO:0015030]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540] identical protein binding [GO:0042802] GNANMVGLA;RKVKKIKKLKED;VKKIKKLKEDISQGVHIS 3 4.7 1.0011 -0.70546 0 9.00784 0 0 0 0 9.96622 0 9.92501 0 0 0 0 0 5.70689 A0A8I3RZM4 A0A8I3RZM4_CANLF Calcium/calmodulin dependent protein kinase II beta CAMK2B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LEMALPPDLQ 1 7.7 0.98973 -0.20269 0 0 10.1033 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZM5 A0A8I3RZM5_CANLF Amyloid-beta A4 protein APP Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; endocytosis [GO:0006897]; Notch signaling pathway [GO:0007219] cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886] heparin binding [GO:0008201]; serine-type endopeptidase inhibitor activity [GO:0004867]; transition metal ion binding [GO:0046914] DTEEYCMAVCGS;EDDEDGDEVEEEA;EEEEAEDDEDDE;EQKDRQHTLKH;MAVCGSVIPT;SDNIDSADAEEDDSDVWWGG;VADVEEEEAEDDEDDEDGDEVEE;VEEEEAEDDEDDED;YADGSEDKVVEVAEEEEVAD 9 11.9 1.0037 -0.87629 0 4.15591 0 6.7654 0 0 0 9.16279 5.65231 0 7.1467 1.71114 0 0 0 A0A8I3RZN1 A0A8I3RZN1_CANLF Cadherin 13 CDH13 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AVLDRESPFVHNSV;EVCDDAKNLSVVILGASDKDL;LVPDVSYGPSST;RPEGSKFRL;SCKNSKVDCNAAG 5 10.2 1.0012 -0.70695 10.0381 0 0 0 4.42901 0 0 0 0 0 0 0 0 0 0 A0A8I3RZN3 A0A8I3RZN3_CANLF Cancer antigen 1 CAGE1 Canis lupus familiaris (Dog) (Canis familiaris) DVQQEIARLRQ;EKLEGVFKADSMNFSS;ETLQLELKRI;ETSPAKSAATEAAL;LDFLVRKTFYCLSK;NELKAKVEELIE;QEKYMTAVQQRDKT;VQLQEHPGEAVE 8 13.3 1.0023 -1.859 11.3801 0 0 8.63001 9.95194 0 0 0 9.71303 0 0 0 0 0 5.17453 A0A8I3RZN4 A0A8I3RZN4_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDLWPSEGEFP;EVHTSKNHC;FYAKSNFNHHQRTHTGE;KSFCMKSHLTVHQRT;KSFCYKSALTIHQRTHTEE;LHVHQGKHTEEKPYKC;SEGEFPDQGDQDRSEEDQNEHLW;VKSNLTKHQ 8 13.2 1.0033 -1.5599 0 5.49953 0 5.44192 0 0 0 0 0 0 8.77827 7.18031 9.54898 11.7861 9.4169 A0A8I3RZP0 A0A8I3RZP0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) IENFSLLKDTKKKKKKK;KDTKKKKKKKKKK;KDTKKKKKKKKKKK;KKKKKKKK;KKKKKKKKKDTTPPP;KKKKKKKKKKK;KKKKKKKKKKKD;LETLYWASKEYILK;LKDTKKKKKKKKKK;LKDTKKKKKKKKKKK;LLKDTKKKKKKKKKKK;LLKDTKKKKKKKKKKKDTTP;TKKKKKKKK;TKKKKKKKKK;TKKKKKKKKKK;TKKKKKKKKKKKDTTPPP 16 35 0.81406 0.20237 2.96626 4.72296 10.2135 0 0 0 0 6.32454 0 6.2639 5.24747 5.42861 4.68347 8.25077 3.4695 A0A8I3RZP4 A0A8I3RZP4_CANLF "Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7" HSD3B7 Canis lupus familiaris (Dog) (Canis familiaris) B cell chemotaxis [GO:0035754]; steroid biosynthetic process [GO:0006694] lipid droplet [GO:0005811] "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity [GO:0047016]" GPCGLRLVETRPLV;LVYTSSMEVVGPNIKGHHF;MEFLGPCGLRLVETRPLV;VGPNIKGHHFYRGNEDTPYEA 4 13 0.98516 -0.44387 0 7.73247 9.49448 0 0 9.02528 0 0 0 0 0 0 0 0 0 A0A8I3RZQ7 A0A8I3RZQ7_CANLF GATA binding protein 5 GATA5 Canis lupus familiaris (Dog) (Canis familiaris) aortic valve morphogenesis [GO:0003180]; cellular response to BMP stimulus [GO:0071773]; endocardial cushion fusion [GO:0003274]; heart induction [GO:0003129]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of gene expression [GO:0010629]; positive regulation of cardiac endothelial to mesenchymal transition [GO:0062000]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]" AGLCCTNC;GTGHYLCNACGLYHKMNGVNR;PAATLKPKPS;YHKMNGVNR 4 9.8 1.0029 -2.4663 0 0 0 0 0 7.95239 0 0 0 0 0 0 5.80766 11.915 6.93227 A0A8I3RZR3 A0A8I3RZR3_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8A2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FIALLQQI;IDGHTLKYALSFE;LKDRAQRLEECYEII;TYVVVTVC;YGRIPPPPSDS 5 4.7 0.99714 -0.59292 9.83091 0 9.6576 7.49617 0 7.01235 10.351 0 0 9.57096 0 0 9.46406 0 10.0111 A0A8I3RZR8 A0A8I3RZR8_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) DTX3 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] SKMAACGG 1 2.3 1.0041 -1.1044 0 0 0 9.45691 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZT5 A0A8I3RZT5_CANLF Paired box 3 PAX3 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]" DPVPGYQYGQYGQ;IVEMAHHGIRPCVI;VPRMMRPG 3 7.2 0.98599 -0.45321 0 0 0 7.68335 0 0 0 0 0 0 12.4826 0 0 0 10.8953 A0A8I3RZT6 A0A8I3RZT6_CANLF Methyltransferase like 24 METTL24 Canis lupus familiaris (Dog) (Canis familiaris) DPSVKSAHILE 1 3.1 0.98391 0.035491 0 0 8.31533 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZT8 A0A8I3RZT8_CANLF DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) POLR3B Canis lupus familiaris (Dog) (Canis familiaris) nuclear lumen [GO:0031981]; RNA polymerase III complex [GO:0005666] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA polymerase III activity [GO:0001056] ELAGQGNWSLKRFK;LDPGGYFI;LRHNTLSE 3 2.8 0.99022 -0.20505 0 0 0 0 0 0 10.1118 0 0 0 0 0 9.07251 0 0 A0A8I3RZU3 A0A8I3RZU3_CANLF Olfactory receptor OR4D6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALELLMISNNGLVTLLWFLL;VTLHFVPCVYIYCR 2 10.9 0.99723 -0.090702 8.84138 0 0 0 0 0 0 0 0 0 0 0 13.072 0 0 A0A8I3RZU6 A0A8I3RZU6_CANLF Beta-defensin Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular region [GO:0005576] LILIIAILLFQKSKVT 1 16.8 0.96328 0.049233 0 0 0 5.03131 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZV0 A0A8I3RZV0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ALQNHYTDLSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;DLSLSHSPG;EALQNHYTDLSLSHSPG;EDGSYFLYSKL;ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;FLYSKLSVDKSR;FPSVLQSSGL;GPSVFIFPPKPKD;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HTFPSVLQSSGL;HYTDLSLSHSPG;IFPPKPKD;ISSDGSSTSYADA;KLSVDKSR;LPSPIERTISKARG;LQNHYTDL;LQNHYTDLSLSHSPG;LSLSHSPG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTDLSLSHSPG;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;QLVESGGDLVKPG;QNHYTDLSLSHSPG;QSSGLYSLSSM;SGGDLVKPG;SGGDLVKPGG;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TDLSLSHSPG;TFPSVLQSSGL;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TYRVVSVL;VESGGDLVKPG;VESGGDLVKPGG;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VQLVESGGDLVKPG;VTVPSSRWPSET;VTVSSASTTA;VTVSSASTTAPSVF;VTVSSASTTAPSVFPL;VTVSWNSGSLTSGVHTFPSVL;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSKLSVDKSRWQQ;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTDLSLSHSPG 111 37.1 0 47.207 14.884 14.9115 15.0608 11.9196 12.162 11.3455 13.9597 13.9663 13.2254 14.6449 13.7426 14.5064 13.6575 13.4682 13.6059 A0A8I3RZV1 A0A8I3RZV1_CANLF CUB domain containing protein 1 CDCP1 Canis lupus familiaris (Dog) (Canis familiaris) DKQPGNMAGN;ESNKIYLVDLSN;FVIPAHLRASV;LVQHPQNESNKIYLV 4 4.8 0.98973 0.020482 7.95501 6.34332 0 0 0 0 0 0 0 0 0 11.7562 0 0 0 A0A8I3RZW2 A0A8I3RZW2_CANLF Cytotoxic and regulatory T cell molecule CRTAM Canis lupus familiaris (Dog) (Canis familiaris) "cell recognition [GO:0008037]; detection of tumor cell [GO:0002355]; establishment of T cell polarity [GO:0001768]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; lymphocyte migration into lymphoid organs [GO:0097021]; negative regulation of activated T cell proliferation [GO:0046007]; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002860]; positive regulation of type II interferon production [GO:0032729]; regulation of CD8-positive, alpha-beta T cell activation [GO:2001185]; regulation of T cell differentiation [GO:0045580]" immunological synapse [GO:0001772] signaling receptor binding [GO:0005102] SVLNVSQRDEGV 1 3.1 0.99135 -0.18576 0 10.7383 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3RZX6 A0A8I3RZX6_CANLF Large ribosomal subunit protein uL4 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GVPGKKPMVGKKGKKAVGVKKQKKT;KEAVLLLKKLK;NPYAKTMRWN;VGKKGKKAVGVKKQKKTLV 4 12.2 0.99258 -0.04865 8.0751 0 0 0 0 0 19.8763 8.02536 0 0 0 0 0 0 7.90551 A0A8I3RZX7 A0A8I3RZX7_CANLF DEAF1 transcription factor DEAF1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599] fibrillar center [GO:0001650]; nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" ASCTCAACCDDMTLSGP;CTCAACCD;GVMGTWRVQW;LSRDEDSEEDGDS;NPHAASCTCAACCDDMT;SCTCAACCDDMT;TLFKSRLG;VLSRDEDSEEDG 8 6.4 1.0036 -1.6371 0 4.23266 0 0 12.2909 3.87243 0 0 0 8.70127 0 0 0 9.72528 6.56878 A0A8I3RZY6 A0A8I3RZY6_CANLF Cyclin dependent kinase 6 CDK6 Canis lupus familiaris (Dog) (Canis familiaris) cell dedifferentiation [GO:0043697]; G1/S transition of mitotic cell cycle [GO:0000082]; gliogenesis [GO:0042063]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of erythrocyte differentiation [GO:0045646]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to virus [GO:0009615]; signal transduction [GO:0007165]; type B pancreatic cell development [GO:0003323] centrosome [GO:0005813]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ruffle [GO:0001726] ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770] IEKFVTDIDEQG;VDLWSVGCIFAEMFRRK 2 8.9 0.99121 -0.20631 0 0 0 0 0 0 10.9267 10.4065 0 0 0 0 0 0 0 A0A8I3RZY7 A0A8I3RZY7_CANLF Cytochrome P450 1A (EC 1.14.14.1) CYP1A2 Canis lupus familiaris (Dog) (Canis familiaris) retinol metabolic process [GO:0042572] endoplasmic reticulum membrane [GO:0005789] aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; lyase activity [GO:0016829] LASTIFCL;NFNQMFVQSLQKIVQ;VTTAISWSLMYLVA 3 7.7 1.0021 -1.204 6.97039 0 0 0 0 0 0 0 0 0 0 10.9227 7.67009 0 0 A0A8I3RZY9 A0A8I3RZY9_CANLF Phenylalanine--tRNA ligase beta subunit B1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] phenylalanine-tRNA ligase complex [GO:0009328] phenylalanine-tRNA ligase activity [GO:0004826] GEIQKLIITEEVIKDRFLFSF;SEKEIISKEQGN 2 25.4 0.97579 0.048037 0 0 0 0 0 0 0 6.27694 0 0 0 0 0 0 0 A0A8I3S008 A0A8I3S008_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCVSSCCQPSCCGSSG;CVSSCCQPCCCRPTCCQT;CVSSCCQPSCCGSSGCGSSC;KPACCVSSCCQPCCCRPTCCQT;PTCCRTTCCEPACSVSSCCQPCCR;TTCCKPACCVSSC;VSSCCQPCCCRPTTCC 7 85.3 0.98396 -0.25264 0 0 0 0 0 0 0 0 0 0 0 0 4.26281 0 0 A0A8I3S015 A0A8I3S015_CANLF Neurotensin receptor 1 NTSR1 Canis lupus familiaris (Dog) (Canis familiaris) adult locomotory behavior [GO:0008344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of gene expression [GO:0010628] membrane raft [GO:0045121]; plasma membrane [GO:0005886] G protein-coupled neurotensin receptor activity [GO:0016492]; identical protein binding [GO:0042802] AFGDAVCRGYYFL;HYFYMLTNALFYVS;MRLNGSAPGPRGAAPGAKPFPLP;QWTPFLYDFYHYFYM 4 14.3 0.98938 0.015329 0 0 0 0 7.19032 0 0 11.1509 8.81407 0 9.21184 0 3.14631 0 0 A0A8I3S018 A0A8I3S018_CANLF Uncharacterized protein ASAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] CCDCGSSE;DLKGVKGD;EITGAEIA;FSSRDSLWNRMP;GSAKTALGPRVLPKLPQKV;KPTELAPKPQI;LDIAKRLKATQCEDLL;VLPKLPQKVAL 8 7.9 1.0001 -2.8336 0 0 6.45172 0 0 7.68004 14.2527 8.14425 8.71194 8.26557 0 0 0 0 0 A0A8I3S022 A0A8I3S022_CANLF PNMA family member 2 PNMA2 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] EEEEEEASFENENIEEP 1 4.7 0.98177 0.046227 0 0 4.15413 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S023 A0A8I3S023_CANLF "Major histocompatibility complex, class II, DQ alpha 1" DLA-DQA1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; positive regulation of T cell differentiation [GO:0045582]; response to type II interferon [GO:0034341] external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]; MHC class II protein complex [GO:0042613] peptide antigen binding [GO:0042605] MIIYSFLLSFHC;MLGQPNTL;NKVLFSLCFLLPAPHPCCSADHVAY 3 13.2 0.99096 -0.14549 0 0 0 0 0 0 9.1443 0 0 0 0 0 0 0 9.67386 A0A8I3S024 A0A8I3S024_CANLF Uncharacterized protein LOC100685322 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCRDPCCCR;CCQPCCCRDPCCC;CGTECCQPSCCQPS;CSSQGCGTECCQPSCCQ;GCGTECCQPSCCQPSCQPS;PCCCRPVSCQTTVCRPVT;PVCCDPCS;QPSCCQPCCC;QPSCQPSCCQPCCCRDPCC;TECCQPSCCQPSCQPSCC 10 40.6 0.80383 0.2079 9.00621 0 0 0 4.53549 0 0 0 5.68148 0 4.31549 0 0 0 0 A0A8I3S039 A0A8I3S039_CANLF "RAB37, member RAS oncogene family" RAB37 Canis lupus familiaris (Dog) (Canis familiaris) regulation of exocytosis [GO:0017157] GTP binding [GO:0005525]; GTPase activity [GO:0003924] VELAFLAI;WLTEIHEYAQRD 2 10.8 1.0022 -1.246 6.79597 0 0 0 0 0 0 0 0 0 0 0 0 9.55105 0 A0A8I3S068 A0A8I3S068_CANLF Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) PPAT Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113] amidophosphoribosyltransferase activity [GO:0004044]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] DDSIVRGN;DINDKEKKSSETEG;DMELEESG;ITQLLAYTPPQE;MELEESGMREECGV 5 9.2 1.0036 -1.0641 0 0 8.07671 0 10.3502 0 0 0 0 0 10.3352 0 14.0707 0 0 A0A8I3S074 A0A8I3S074_CANLF "FYVE, RhoGEF and PH domain containing 4" FGD4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] ISTAASHSNSAIRK;RACGHVVCWKC;VNGEGEEEATTRPA;VNKIFSNISSINAFH;VSQQPPQKQEN;YAKECRPATQ 6 10.4 0.9932 -0.17609 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.6788 A0A8I3S088 A0A8I3S088_CANLF BRF2 RNA polymerase III transcription initiation factor subunit BRF2 Canis lupus familiaris (Dog) (Canis familiaris) NEQVSRSQQRE;VDDSHYSQSQ 2 29.2 0.99675 -0.57597 0 0 0 0 0 0 0 0 0 7.42408 0 0 6.87271 0 0 A0A8I3S090 A0A8I3S090_CANLF Zinc finger protein 410 ZNF410 Canis lupus familiaris (Dog) (Canis familiaris) PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" DEAEDSGN;LSDELESKPELL 2 4.9 1.0028 -1.3433 0 0 0 0 0 0 0 0 11.9323 0 0 8.27747 6.69822 0 0 A0A8I3S095 A0A8I3S095_CANLF Selenoprotein N SELENON Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ELSVFTGYLSNNRF;KALGTEGLFLFSSL;RVGGDLPGGAA;SEPPDFPFWF 4 9.7 1.0017 -0.74999 0 9.06391 0 0 0 0 9.95909 0 0 0 0 0 0 0 5.84341 A0A8I3S097 A0A8I3S097_CANLF C2H2-type domain-containing protein KLF16 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APSPLNHPART;SPAPGPGQ 2 2.6 1.0029 -1.3528 0 0 0 0 0 0 0 0 0 6.93133 0 0 9.40846 0 0 A0A8I3S0A2 A0A8I3S0A2_CANLF Transcription elongation factor 1 homolog ELOF1 Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] transcription elongation factor complex [GO:0008023] metal ion binding [GO:0046872]; RNA polymerase II complex binding [GO:0000993] LEEFQTPITYLSEPVDV 1 20.5 0.97968 0.046227 0 0 6.63185 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0A4 A0A8I3S0A4_CANLF Calcium-transporting ATPase (EC 7.2.2.10) ATP2A3 Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388] EGRAIYNNMKQ;LPRNPHEALISGWLFFR;LVPPLPLIFQV;LVTDGLPAT;PVILLDEALKYLSRNHMDAC;SGTTYAPEGEVRQ;SPVERASA;VYVGLATVAAA;WFEEGEETTTA 9 10.5 1.0028 -0.79044 0 10.3836 4.88411 10.1721 0 0 0 0 0 8.94433 0 9.13786 0 0 0 A0A8I3S0A5 A0A8I3S0A5_CANLF Chromosome 3 open reading frame 49 C20H3orf49 Canis lupus familiaris (Dog) (Canis familiaris) SVSRGASTNHK 1 3.8 0.9868 -0.23178 0 0 0 0 0 0 0 0 0 0 0 10.4635 0 0 0 A0A8I3S0A6 A0A8I3S0A6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) IYVTCQVEKFYPQ;STEQRLIFP 2 4.7 0.99009 -0.26572 0 0 0 0 0 0 0 0 0 0 0 0 0 9.60198 0 A0A8I3S0A8 A0A8I3S0A8_CANLF Tripartite motif containing 25 TRIM25 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to leukemia inhibitory factor [GO:1990830]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; ERAD pathway [GO:0036503]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; regulation of protein localization [GO:0032880]; response to estrogen [GO:0043627]; response to oxidative stress [GO:0006979]; suppression of viral release by host [GO:0044790]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral release from host cell [GO:0019076] cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear body [GO:0016604] metal ion binding [GO:0046872]; RIG-I binding [GO:0039552]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630] ESRLGRNSASWCVEW;PKRFTYCSQVLGLHCYK 2 5.1 0.9382 0.10011 0 8.14603 0 0 0 0 0 0 0 0 0 0 0 0 5.54377 A0A8I3S0E4 A0A8I3S0E4_CANLF Olfactory receptor OR4F63 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QMFFIHTVGGTEMVL;VFFFGPCI 2 7.1 0.99181 -0.20839 7.5735 4.81127 0 0 4.94734 0 0 0 0 0 7.3222 0 0 0 0 A0A8I3S0G7 A0A8I3S0G7_CANLF EPH receptor B6 EPHB6 Canis lupus familiaris (Dog) (Canis familiaris) activated T cell proliferation [GO:0050798]; positive regulation of T cell costimulation [GO:2000525]; type IV hypersensitivity [GO:0001806] cell surface [GO:0009986]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] CRRCRDEVHFDPRQRGLTESRVL;EAPCTGPPSAPRE;GAGQRAGLQLN;GNILDYQLRYYDQAE;LHFSVRACASL;LVSSVLALEEVLLDTTGET;VLDDQRRLTRT 7 10.2 0.98645 -0.42371 0 0 0 12.7226 0 13.0646 7.16189 9.77841 0 0 0 8.87833 0 8.35522 0 A0A8I3S0I0 A0A8I3S0I0_CANLF SKI3 subunit of superkiller complex SKIC3 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled ribosome [GO:0072344]" cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; Ski complex [GO:0055087] EVAEYHYQL;GWYHLAEAQIKMHRPKEAVLSCN;HLAEAQIK;QNYAPAFTMLGYLNEHLQLKKEAAD;QQGSWSGKLSSLLKLALLAL;TLQDKSNRDTELYRYNIVQMNAI;VHSNPADPA;YLASENIEQAHEAFKM 8 8 1.0013 -0.95018 6.97579 0 6.34846 5.80318 0 0 0 0 10.6051 9.71466 0 0 8.39249 10.0411 9.94544 A0A8I3S0I9 A0A8I3S0I9_CANLF IQ motif containing F2 IQCF2 Canis lupus familiaris (Dog) (Canis familiaris) EITELKKRRKQKLKKKS;ITELKKRRKQKLKKKSLKKK;IVIEDVEEITELKKRRKQKLKKKS;KKRRKQKLKKKSLKKK;KQKLKKKSLKKKTKA;LKKKSLKKKTKA;LKKRRKQKLKKKSLKKK;QKLKKKSLKKK;RRKQKLKKKSLKKKT 9 19.1 0.54211 0.42487 9.31404 0 10.8385 3.55287 0 8.12872 0 9.07551 9.73166 7.24384 8.19446 9.11465 10.0828 7.79422 10.2322 A0A8I3S0J0 A0A8I3S0J0_CANLF PPIase cyclophilin-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) peptidyl-prolyl cis-trans isomerase activity [GO:0003755] LFWDFCARIP 1 12.3 0.98418 -0.23816 0 9.84987 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0K5 A0A8I3S0K5_CANLF Purinergic receptor P2Y11 P2RY11 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; neuronal signal transduction [GO:0023041] plasma membrane [GO:0005886] G protein-coupled ATP receptor activity [GO:0045031]; neurotransmitter receptor activity [GO:0030594] CPMLVVEFLVAVASN;GCCHQSCCSCSN;SLGCCHQSCCSCSNSQMPED 3 9.5 0.85973 0.15252 0 3.56888 0 3.06247 0 0 0 0 0 5.59839 0 0 0 5.43293 0 A0A8I3S0L9 A0A8I3S0L9_CANLF Peter pan homolog PPAN Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364] "nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]" rRNA binding [GO:0019843] AQNVQRKREQREAH;VAVAGPLGVTHF 2 5.5 0.91624 0.11136 0 0 0 0 0 9.28628 0 4.74233 0 0 0 0 0 0 0 A0A8I3S0M3 A0A8I3S0M3_CANLF Cathepsin B (EC 3.4.22.1) CTSB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis involved in protein catabolic process [GO:0051603]; symbiont entry into host cell [GO:0046718]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosome [GO:0005764]; peptidase inhibitor complex [GO:1904090]; perinuclear region of cytoplasm [GO:0048471] collagen binding [GO:0005518]; cysteine-type endopeptidase activity [GO:0004197]; proteoglycan binding [GO:0043394] AEDMLTCCGDQCGDGC;CEPGYSPSYKEDKH;CGDGCNGG;CGDQCGDGCN;GIESEIVAGIPCSAP;MLTCCGDQCGDGCN;YQHVTGEMMGG 7 17 1.0032 -2.1364 5.96993 0 7.45393 5.40565 0 0 0 0 0 0 5.99695 0 0 6.09436 0 A0A8I3S0M9 A0A8I3S0M9_CANLF PRELI domain containing protein 3B (Protein slowmo homolog 2) PRELID3B Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial intermembrane space [GO:0005758] WVIHKLNAEIEELAASARGSIRTP 1 14.6 0.97392 0.041303 8.15391 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0N2 A0A8I3S0N2_CANLF V-set and immunoglobulin domain-containing protein 1 VSIG1 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell morphogenesis [GO:0003382]; maintenance of gastrointestinal epithelium [GO:0030277] plasma membrane [GO:0005886] KTTTELEPMTKVN;LEPMTKVNQ;MTKVNQSTEFEAM 3 5.5 0.98742 -0.37836 7.97659 11.757 8.11067 0 0 0 0 0 0 0 0 8.22968 0 0 9.45337 A0A8I3S0P5 A0A8I3S0P5_CANLF Xin actin binding repeat containing 2 XIRP2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281] focal adhesion [GO:0005925]; stress fiber [GO:0001725]; Z disc [GO:0030018] actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393] AEPGKGGL;APAPVPEG;ASPEIQKEEI;EAPLPGTESGVT;EASAWRREAATPR;ETQPLEKIKEES;FETTPLYAIQ;GAAPCPAA;GNVKRSIKCFETQ;GVPSSRQAEFS;IDQFDESIHKFQIIRGISAQEIQ;KELIRDDLEI;KGDVKACTWLFETKPLDT;MARYQAAV;MIAEEKYRQQ;NCRWLFENQPIDMIK;NLQEEKGLE;PLPGTESGVTLAQPDPNP;SAAEKYYHLPKREKRVTITLPT;SLDERKQLSMDSMRS;SNGVPSSR;SVKSPRSTPNLKIP;TLGDHSSG;VLKKIKALK;VLKKIKALKT 25 8.4 0.99664 -8.6444 6.99084 12.097 0 9.81802 0 10.6433 0 10.4737 10.622 9.246 11.7024 9.70028 11.1761 11.1747 6.55957 A0A8I3S0P6 A0A8I3S0P6_CANLF Transmembrane protein 61 TMEM61 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGLEDRASGDALLGAQCPP 1 9.1 0.94966 0.049903 0 0 0 0 0 0 0 0 0 0 6.07245 0 0 0 0 A0A8I3S0Q0 A0A8I3S0Q0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLMKPG;EVQLVESGGDLMKPGG;ISSDGSSTSYADA;LKGAQGEVQLVESGGD;VRQAPGKGLQ 9 36 0 3.4008 0 10.1573 10.4773 8.10926 0 0 11.1548 0 10.3569 9.00371 0 10.6745 0 0 9.82203 A0A8I3S0Q7 A0A8I3S0Q7_CANLF Uncharacterized protein LOC100686813 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LDCGRMTTLLYRLQ;QTSILSSLPSF 2 31.2 0.9398 0.060769 0 0 0 0 0 6.90557 0 0 0 0 0 0 0 0 0 A0A8I3S0R5 A0A8I3S0R5_CANLF Sialic acid binding Ig like lectin 1 SIGLEC1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of type I interferon production [GO:0032480] plasma membrane [GO:0005886] ADTGFYFCEVHN;DLQLEGVQVTLAPSAA;KSDPPAHLRLLHGHHLMASTLQ;LTEAETQLSTPV;SHNGLVLASTQ;TCLVWTTNLTQPTYTWYRDGQQRPG;TPETPTIASAAE 7 6.4 1.0025 -1.1846 0 9.84108 0 0 9.67402 0 0 0 0 0 0 6.5725 0 0 9.01036 A0A8I3S0S4 A0A8I3S0S4_CANLF Membrane metalloendopeptidase like 1 MMEL1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] EERHDVTALYHRMGL;IDVYSARTMQN;NGFSTLGENIADNGGV;RILQNMDPSREPCEDF;SALHFPLARDLV;SKEEKTIVKRKPRAIQ;SYLVREDMVQ 7 11.9 1.0026 -0.73381 0 11.2959 8.54435 0 0 8.44 0 0 0 11.0622 0 10.4914 0 0 0 A0A8I3S0T4 A0A8I3S0T4_CANLF ATP binding cassette subfamily C member 8 ABCC8 Canis lupus familiaris (Dog) (Canis familiaris) inward rectifying potassium channel [GO:0008282] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; potassium channel activity [GO:0005267]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325] GLPRAMSSRDGLL;LNRFSADCNTID;LPPPDHSQPLKVVNRKHPARE;SLPPPDHSQPLKV;SYVTPVFL;VASRDLQQLDDTTQL;VHTILSADLVIVLKRGAIL 7 5.6 1.0035 -1.0575 9.89964 0 9.2962 7.41726 0 4.70813 0 0 10.2262 0 8.86876 0 7.76514 0 0 A0A8I3S0U3 A0A8I3S0U3_CANLF Decapping nuclease (EC 3.6.1.-) DXO Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723] LDAQRQYHGDAHA 1 3.3 0.94538 0.059648 0 0 7.89887 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0V0 A0A8I3S0V0_CANLF Interleukin 6 receptor IL6R Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] LAVPEGDNSLYVV;VGIVLRFKKTWKLHALK 2 6.9 0.99372 -0.16196 0 0 0 0 0 7.29664 0 0 12.9385 0 0 0 0 0 0 A0A8I3S0V1 A0A8I3S0V1_CANLF "Oxaloacetate tautomerase FAHD1, mitochondrial (EC 3.7.1.5) (EC 4.1.1.112) (EC 5.3.2.2) (Acylpyruvase FAHD1) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase)" FAHD1 Canis lupus familiaris (Dog) (Canis familiaris) pyruvate metabolic process [GO:0006090] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] acetylpyruvate hydrolase activity [GO:0018773]; fumarylpyruvate hydrolase activity [GO:0034545]; metal ion binding [GO:0046872]; oxaloacetate decarboxylase activity [GO:0008948] LMPAYTRNLHHELE;QEGDTSSMIFSIPYIIS;RFWEWGKNI 3 17.7 1.0028 -0.98401 0 10.1755 0 0 0 0 0 0 10.5717 0 0 0 0 8.68682 0 A0A8I3S0V5 A0A8I3S0V5_CANLF Olfactory receptor OR2T27 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VTMQFPFCASREI 1 4.1 0.98891 -0.26151 0 9.57134 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0W7 A0A8I3S0W7_CANLF PTPRF interacting protein alpha 1 PPFIA1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AGPAAASETENSSQ;IKSSIGRLFGKKEK;LGLSKLGG;MNEEHNKRLSDT;QLMVSMLEERDR;SMLEERDRLLDTL;VETAKKQLE;VETAKKQLEEAQ 8 6.5 1.0026 -1.8529 0 0 0 0 0 10.304 0 0 0 12.5501 0 0 9.45041 0 0 A0A8I3S0X7 A0A8I3S0X7_CANLF SURP and G-patch domain containing 1 SUGP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] FQSPDEDEEEDYEQ;PAAACPASSAPSPAVTPA 2 5 0.98999 -0.21693 0 0 5.35142 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0Y0 A0A8I3S0Y0_CANLF Cysteine protease (EC 3.4.22.-) ATG4A Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; lipid metabolic process [GO:0006629]; protein transport [GO:0015031]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786] DRKDCCYSIHQMAQMGVGE 1 5.7 0.98923 -0.20368 0 0 0 0 0 0 6.12608 0 0 11.5482 11.6519 0 0 0 0 A0A8I3S0Y3 A0A8I3S0Y3_CANLF Sidekick cell adhesion molecule 1 SDK1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] DIVCRAMGVPLPTLQW;LDAGFYRCVVRNRMGALL;LLAGLRKFV;NQSIMVQWQPP;SICSAFFE;SKVVTVDVNGNWQRW;TATLRCGA;TSADTGLYVC;TTYTSEYKYIIPSLQ;VGRGQYSAETSRL 10 5.9 0.99817 -3.3198 10.2725 0 10.0881 0 0 12.8006 0 0 9.15563 0 0 3.68437 0 0 0 A0A8I3S0Y4 A0A8I3S0Y4_CANLF Uncharacterized protein TRA2B Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" spliceosomal complex [GO:0005681] RNA binding [GO:0003723] GGGGGGGG;KKGHLLLP;RLKPVERR;VTSGSGRA 4 6.8 1.0032 -2.1275 0 8.1632 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S0Y6 A0A8I3S0Y6_CANLF Cholecystokinin CCK Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586] axon [GO:0030424]; extracellular space [GO:0005615] neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428] EDEAPRRQLRAVQKVDGEP 1 16.7 0.94831 0.04956 0 0 0 0 0 0 8.13443 0 0 0 0 0 0 0 0 A0A8I3S0Y9 A0A8I3S0Y9_CANLF Transmembrane 6 superfamily member 2 TM6SF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of lipid metabolic process [GO:0019216] endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116] identical protein binding [GO:0042802] IFPGCSWLPDW;MLVYMFYVMPFYGLA;PVDLALVIYLTLT 3 10.4 0.99194 -0.033915 0 0 0 7.00315 12.3082 0 6.1516 0 0 0 0 0 0 0 0 A0A8I3S0Z2 A0A8I3S0Z2_CANLF Alkaline ceramidase (EC 3.5.1.-) ACER2 Canis lupus familiaris (Dog) (Canis familiaris) ceramide catabolic process [GO:0046514]; sphingosine biosynthetic process [GO:0046512] membrane [GO:0016020] dihydroceramidase activity [GO:0071633] LCASKKSP 1 2.9 0.98924 -0.2632 0 0 0 0 0 9.55227 0 0 0 0 0 0 0 0 0 A0A8I3S105 A0A8I3S105_CANLF Activating transcription factor 6 beta ATF6B Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EDWGLRNSTLYTGLD;SSWMQLTDERTPFM;TDERTPFMLCLSEGTTCCF 3 6.4 0.85895 0.16943 0 8.70808 0 0 0 4.88029 0 6.16354 0 0 0 0 0 0 0 A0A8I3S110 A0A8I3S110_CANLF Proline and arginine rich end leucine rich repeat protein PRELP Canis lupus familiaris (Dog) (Canis familiaris) cellular senescence [GO:0090398] extracellular region [GO:0005576] INNKLEHLYLNNNS;LDNNRIRKIDQKVLEKLPSLVFLYM;LRKMPPKVPAA 3 13.2 0.99261 -0.15058 10.6286 0 4.00953 0 0 0 0 11.8511 0 0 0 0 0 0 0 A0A8I3S130 A0A8I3S130_CANLF Stearoyl-CoA desaturase 5 SCD5 Canis lupus familiaris (Dog) (Canis familiaris) unsaturated fatty acid biosynthetic process [GO:0006636] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; stearoyl-CoA 9-desaturase activity [GO:0004768] VIEKGRKLDVTD;VLMCFVIP 2 6.2 0.98762 -0.48454 0 0 0 0 0 8.61114 16.4073 0 0 0 0 0 0 0 0 A0A8I3S135 A0A8I3S135_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TOPORS Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AERTPELV;EDTECDNS;EFFRRNPACLHRLVP;HKKKKKKHKKKHKKHH;LDVREESTFA;SGDSDVSRCSSPHSV;SRSLSSNRSKTAST;YYYYERHRS 8 9.2 1.0029 -2.1671 0 0 0 0 0 0 0 0 0 9.77447 8.03903 0 10.2 10.091 0 A0A8I3S141 A0A8I3S141_CANLF Transmembrane protein 74B TMEM74B Canis lupus familiaris (Dog) (Canis familiaris) PPGLLTWDEVWH 1 4.8 0.98719 -0.23006 8.95994 0 0 8.46516 0 0 0 9.38662 9.16229 0 0 0 0 0 0 A0A8I3S154 A0A8I3S154_CANLF Thymidine kinase (EC 2.7.1.21) TK1 Canis lupus familiaris (Dog) (Canis familiaris) DNA synthesis involved in mitotic DNA replication [GO:1904860]; protein homotetramerization [GO:0051289]; thymidine biosynthetic process [GO:0046105] nucleus [GO:0005634] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270] VEFSETMANAGK;VIKYAKDTRYSNSFSTHDRNTM 2 14 0.99176 -0.20662 0 0 0 6.36567 0 0 0 0 11.8614 0 0 0 0 0 0 A0A8I3S158 A0A8I3S158_CANLF Alpha-synuclein SNCA Canis lupus familiaris (Dog) (Canis familiaris) regulation of dopamine secretion [GO:0014059] axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; synapse [GO:0045202] metal ion binding [GO:0046872] GVTAVAQKTVE;VEGAGSIAAATGF 2 19.6 0.92402 0.095077 7.55819 0 0 0 0 0 0 9.47652 0 0 0 0 0 0 0 A0A8I3S163 A0A8I3S163_CANLF Nuclear transcription factor Y subunit NFYA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] CCAAT-binding factor complex [GO:0016602]; nucleoplasm [GO:0005654]; protein-DNA complex [GO:0032993] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AQVASASGQQVQTLQVVQGQP 1 6.1 0.9849 -0.24026 0 0 0 0 0 0 0 12.8418 0 0 0 0 0 0 0 A0A8I3S175 A0A8I3S175_CANLF Suppressor of cytokine signaling 4 SOCS4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567] SIEDSDMDSDDE;VSNNSIEDSD;VTGSVMNLVSN 3 5.5 0.98915 -0.52553 0 0 0 0 0 9.81818 0 0 0 0 0 6.80465 6.85786 0 0 A0A8I3S185 A0A8I3S185_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC100686261 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ATGALCTLFTTILNYMFS;LVAGLSSVLAGLCYA;MMQMIAGTW 3 7.2 1.0028 -0.79728 9.27889 0 0 0 0 0 0 0 0 0 0 0 10.936 0 0 A0A8I3S188 A0A8I3S188_CANLF Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30 kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit) Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] metal ion binding [GO:0046872]; RNA binding [GO:0003723] AGVSRSFYSTCSL;LAPHYAQPSLSHDLLQ;LVGVCPKG 3 21 1.0027 -1.4034 0 0 0 6.54811 0 0 0 0 0 0 6.77926 0 0 0 0 A0A8I3S189 A0A8I3S189_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VPPKAKGG 1 4.3 0.99067 -0.26592 0 0 0 0 0 0 0 0 0 10.3147 0 0 0 0 0 A0A8I3S192 A0A8I3S192_CANLF Dishevelled binding antagonist of beta catenin 1 DACT1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of beta-catenin-TCF complex assembly [GO:1904864]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; regulation of protein stability [GO:0031647] beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] beta-catenin binding [GO:0008013]; histone deacetylase binding [GO:0042826]; protein kinase A binding [GO:0051018]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] AAPRSAPRHRGAQ;AEPEGRWREKGEADTERQRTR;GHCEDQASG;RKGGGGQPEAGAPCRGLGAGQ;RLEEKFLEENILLLRKQLNCLRR;SSCHSSTCFCSP 6 12 1.0039 -0.80924 0 0 4.38612 3.65947 9.39079 0 9.59524 7.72185 0 0 0 0 0 0 0 A0A8I3S1A4 A0A8I3S1A4_CANLF TGF-beta family profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] AAGWASGH;LHDLLSCGQ 2 6.2 1.0034 -0.80421 0 8.22018 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S1B2 A0A8I3S1B2_CANLF Olfactory receptor family 13 subfamily P member 4 OR13P4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KKLALFYNVVSAFLNP 1 5.1 0.96084 0.049233 0 0 5.3845 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S1B4 A0A8I3S1B4_CANLF Transcription elongation factor A N-terminal and central domain-containing protein 2 TCEANC2 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] SEALELEMDHLL 1 5.8 0.94353 0.05044 0 0 0 0 0 0 0 0 0 0 0 10.0135 0 0 0 A0A8I3S1B5 A0A8I3S1B5_CANLF Chromosome 17 C2orf81 homolog C17H2orf81 Canis lupus familiaris (Dog) (Canis familiaris) DPMWCEDEE;EATSQVMWKPMLLPDAMKLA;EDPMWCEDEEPLACTT;SPPVEQHPIPT 4 8.2 0.94561 0.084241 0 0 0 0 0 7.46744 0 0 9.29554 0 0 3.7182 0 0 0 A0A8I3S1B9 A0A8I3S1B9_CANLF Coiled-coil serine rich protein 1 CCSER1 Canis lupus familiaris (Dog) (Canis familiaris) EVLLQITELPVM;LMGTVPCAI;LVSRLPIFRRSISRRHD;REATYRNRIV 4 5.3 0.9892 -0.26514 10.3638 0 0 0 0 0 0 0 10.889 0 0 0 0 0 0 A0A8I3S1C3 A0A8I3S1C3_CANLF "ArfGAP with SH3 domain, ankyrin repeat and PH domain 3" ASAP3 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; regulation of stress fiber assembly [GO:0051492] cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; ruffle [GO:0001726] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] AAIGTVNEAGETALD;ESDMNTRRDY;GQCCDCGA;PQSQSEVGPPPLPVKN;SEVGPPPL;TVNEAGETALDIARK;VAEFLAVTAEDLSSPAGA 7 8.1 1.0041 -2.0239 0 9.50783 0 9.90773 8.97983 0 8.3332 9.14682 0 0 0 0 5.6626 0 6.9465 A0A8I3S1E9 A0A8I3S1E9_CANLF Uncharacterized protein GFRA3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] APPTALLLALLLLLLLLPRPL;DLQPARVEERAT;LLLLLLLL;LLLLLLLLP;LLLLLLLP;TALLLALLLLLLLLPRPLR;WTVHLARSLGDYE 7 11 0.98419 -0.25292 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9319 0 A0A8I3S1F9 A0A8I3S1F9_CANLF SRY-box transcription factor 7 SOX7 Canis lupus familiaris (Dog) (Canis familiaris) endoderm formation [GO:0001706]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of canonical Wnt signaling pathway [GO:0060828] cytoplasm [GO:0005737]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription cis-regulatory region binding [GO:0000976]" GGGGGGGG;GPSGGGGGGGGTPGSVDTY 2 4.9 0.9873 -0.22972 0 0 0 0 0 8.07703 0 0 0 0 0 0 0 0 0 A0A8I3S1G8 A0A8I3S1G8_CANLF Chromosome 8 open reading frame 74 C8orf74 Canis lupus familiaris (Dog) (Canis familiaris) FPWVEVAEVV;WVEVAEVVKFTEE 2 5.1 0.99083 -0.53921 0 9.47841 0 0 0 0 0 11.1244 0 0 0 0 0 0 0 A0A8I3S1H0 A0A8I3S1H0_CANLF Conserved oligomeric Golgi complex subunit 1 COG1 Canis lupus familiaris (Dog) (Canis familiaris) intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031] Golgi transport complex [GO:0017119]; membrane [GO:0016020] SRFPILIRQV;TLQEMLKSCMVQVVAAYE;VDAVKATDQYCAR 3 4.5 1.0039 -0.8274 0 8.50993 0 0 0 6.86134 0 0 0 0 0 0 0 10.4019 0 A0A8I3S1H2 A0A8I3S1H2_CANLF Protein phosphatase 2 regulatory subunit B''alpha PPP2R3A Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EEYETLVAEESAQ;FEDYETEE;IAKLCGCPLYWKAPMFRAA;LSEKCGKL;QADLSRYNDQASSNRII;RRDPDLRGELAFL;YTVNRSWSGKITS 7 17.1 0.94134 0.059813 0 0 0 0 0 0 0 0 0 0 0 0 0 9.92016 0 A0A8I3S1H6 A0A8I3S1H6_CANLF Dishevelled segment polarity protein 2 DVL2 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; convergent extension involved in neural plate elongation [GO:0022007]; heart looping [GO:0001947]; intracellular signal transduction [GO:0035556]; outflow tract morphogenesis [GO:0003151]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization [GO:0008104]; regulation of cell population proliferation [GO:0042127]; segment specification [GO:0007379] aggresome [GO:0016235]; apical part of cell [GO:0045177]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; nuclear body [GO:0016604] frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267] ENLEPETETESVVSLRRERPRRRDS;GVPNLRAHPGLHPYGPPPGMALP;LSGGCESY;LSGGCESYLV;PRRRDSSEHGAGGHRPG;RLLKRHRRRRKQ;YHELSSYTYGGGSASS 7 13.2 0.98481 0.046227 0 0 0 0 0 7.61897 0 0 0 0 0 0 0 0 0 A0A8I3S1I6 A0A8I3S1I6_CANLF Dynactin subunit 1 DCTN1 Canis lupus familiaris (Dog) (Canis familiaris) "centriole-centriole cohesion [GO:0010457]; establishment of mitotic spindle orientation [GO:0000132]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; motor behavior [GO:0061744]; neuromuscular junction development [GO:0007528]; neuromuscular process [GO:0050905]; neuron cellular homeostasis [GO:0070050]; neuron projection maintenance [GO:1990535]; non-motile cilium assembly [GO:1905515]; nuclear membrane disassembly [GO:0051081]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of neuromuscular junction development [GO:1904398]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; ventral spinal cord development [GO:0021517]" cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; dynein complex [GO:0030286]; intercellular bridge [GO:0045171]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; retromer complex [GO:0030904]; spindle pole [GO:0000922] microtubule binding [GO:0008017]; protein kinase binding [GO:0019901] CLRQSSNILIS;DETVNVEPLT;FTCDEGHGIFV;HTHVVDIT;KDADERIEKV;LAAGALYRKTSQL;VSGIAGEEQQRGGAP 7 6.1 1.004 -2.025 9.8321 0 10.6758 0 0 0 0 0 10.5518 0 0 10.1357 0 10.6654 9.45535 A0A8I3S1I7 A0A8I3S1I7_CANLF Synaptonemal complex protein 2 SYCP2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] ESKKLLTIILKNIIKIS;ESLIDRYILVF;FFNTVMNRKNINSVV;GVNISLYFYRNDVYN;HMKQKSPSSISE;IEVMRCTEKI;KKLLTIILKNIIKISKRE;PILLTNTSAPRRGRTK;SLKDLEKEFV;YFTKQSWKTAQQHLNTMNQQIQ 10 10 1.0031 -0.83851 8.35473 9.77269 4.081 0 0 8.53629 0 0 13.7593 4.68633 3.82426 0 7.7807 9.66292 7.04789 A0A8I3S1J6 A0A8I3S1J6_CANLF "Large ribosomal subunit protein uL10m (39S ribosomal protein L10, mitochondrial)" MRPL10 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial large ribosomal subunit [GO:0005762]; nucleoplasm [GO:0005654] EDKLLIRHRLRKHKIL;LDQYIRQQQEGDS;LLIRHRLRKHKILMKIFPN 3 10.7 0.85342 0.15847 4.56578 0 11.2684 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S1K2 A0A8I3S1K2_CANLF Spermatogenesis associated 22 SPATA22 Canis lupus familiaris (Dog) (Canis familiaris) gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA repair synthesis [GO:0000711] VIESMKYWREHA 1 4.4 0.99679 -0.10936 0 0 0 0 0 0 0 0 14.1549 0 0 0 0 0 0 A0A8I3S1K5 A0A8I3S1K5_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" B4GALT1 Canis lupus familiaris (Dog) (Canis familiaris) acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; lactose biosynthetic process [GO:0005989]; lipid metabolic process [GO:0006629]; macrophage migration [GO:1905517]; negative regulation of epithelial cell proliferation [GO:0050680]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of circulating fibrinogen levels [GO:0061755]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046] basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; desmosome [GO:0030057]; external side of plasma membrane [GO:0009897]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; protein-containing complex [GO:0032991] "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; lactose synthase activity [GO:0004461]; manganese ion binding [GO:0030145]; N-acetyllactosamine synthase activity [GO:0003945]" FDRIAHTKETIHSLKSQW;GSAAMPGASLQRACR 2 7.6 0.99141 -0.30015 0 0 0 0 0 0 9.321 0 10.1262 0 0 0 0 0 0 A0A8I3S1L0 A0A8I3S1L0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] IIQEYWQSKVFYNKMKGHYYRHLAE;YNKMKGHYYRHLAE 2 32.9 0.93675 0.098119 0 0 0 0 0 9.31857 0 0 0 0 8.71167 0 0 0 0 A0A8I3S1L6 A0A8I3S1L6_CANLF Spermatogenesis associated serine rich 2 SPATS2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] CASATSLTSANKKNSAPG;SPCDASAASSST 2 5.5 0.93405 0.098753 0 0 0 0 8.0705 0 7.54574 0 0 0 0 0 0 0 0 A0A8I3S1L7 A0A8I3S1L7_CANLF Nanos homolog 1 NANOS1 Canis lupus familiaris (Dog) (Canis familiaris) "cerebellar neuron development [GO:0098749]; epithelial cell migration [GO:0010631]; negative regulation of translation [GO:0017148]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of cell growth [GO:0001558]; tissue homeostasis [GO:0001894]" perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] DDDDDSDGDE;DDDDSDGDEPGS;FGGEGGGG;GGGGGGGA;GGGGGGGG;LGPALGPPDDDDDSDGDE;PPSSSSSSCCSPHA 7 16.7 1.0031 -1.9427 0 0 0 0 0 0 0 0 0 6.23862 4.42667 8.82483 0 4.10014 0 A0A8I3S1M8 A0A8I3S1M8_CANLF Kallikrein 1 KLK1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GGGGGGGD;GGGGGGGG;SQPVLLPHPQ;VPGSVPCP 4 7.6 1.0029 -1.7158 0 0 0 0 0 0 0 0 0 8.02774 0 0 9.51306 0 0 A0A8I3S1N1 A0A8I3S1N1_CANLF DNA polymerase theta POLQ Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; error-prone translesion synthesis [GO:0042276]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; replication fork processing [GO:0031297]; somatic hypermutation of immunoglobulin genes [GO:0016446] cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; magnesium ion binding [GO:0000287]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; single-stranded DNA helicase activity [GO:0017116] DEEEEAAEERRHMRT;DIIACEFYNL;DLHIVYLVTPM;EWRRITNAITKVVFPLQREKR;FSTTECESQKH;GVNLPARRVIIRTPIFGGQPLD;LAPCEFEDSF;PVKDTGMD;PVYCEDSFTLD;RAIELSVKLKVRVKIGASWGDLK;SLVPPSLDPSLTVK;TDSFYCKLQNGNQ;TDTLDIFADLQ;TLHSTFKSH;VLEKYHSYGVKRMFEWQA;VSLCYETICDNHS 16 8.5 1.0017 -2.6465 8.20428 10.6702 0 7.9462 0 0 9.12933 11.8643 0 11.3799 8.70822 10.6672 10.0827 0 11.4375 A0A8I3S1N8 A0A8I3S1N8_CANLF DnaJ homolog subfamily C member 22 DNAJC22 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVAAVGNQ 1 2.4 0.98999 -0.26575 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.74281 A0A8I3S1Q2 A0A8I3S1Q2_CANLF Purine rich element binding protein G PURG Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; synapse [GO:0045202] purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977] HSLGQEQTIVLP 1 4.1 0.99315 -0.28358 0 10.7661 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S1R3 A0A8I3S1R3_CANLF Kelch like family member 40 KLHL40 Canis lupus familiaris (Dog) (Canis familiaris) AAGATFLP;EVYSIADNKWASF;KKMCVYDPKKFEWKELAPM;RAQPELLRKVQM 4 8.3 1.0017 -1.3137 0 0 0 0 8.00669 7.78686 0 0 8.53943 0 0 10.0314 10.0403 7.693 0 A0A8I3S1S1 A0A8I3S1S1_CANLF pyridoxal 5'-phosphate synthase (EC 1.4.3.5) PNPO Canis lupus familiaris (Dog) (Canis familiaris) pyridoxine biosynthetic process [GO:0008615] FMN binding [GO:0010181]; pyridoxamine phosphate oxidase activity [GO:0004733] DGFRFFTNFESRKGRELVR;GVVMDLGP;PSARMVLLKGFG 3 16 0.9532 0.04941 0 0 0 0 7.45063 0 0 0 0 0 0 0 0 0 0 A0A8I3S1S4 A0A8I3S1S4_CANLF "Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78)" PIP4P2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670] "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]" LLLLLLLL;LLLLLLLLL;LLLLLLLLLPRPSLLLRL;LLLLLLLLP;LLLLLLLLPRPSLLLRLP;LLLLLLLLPRPSLLLRLPP;LLLLLLLP;LLLLLLLPRPSLLLRL;LLLLLLPRPSLL;LLLLLLPRPSLLLRLPPRPPS;PSLLLLLLLLLPRPSL;SLLLLLLLLLPRPSLLL;SLLLLLLLPGPA;SPRPSLLLLLLLLLPRP 14 8.4 0.92124 0.11231 6.93699 5.41498 0 7.03111 0 0 0 7.5598 0 4.90096 4.65638 0 0 0 0 A0A8I3S1T4 A0A8I3S1T4_CANLF Beta 3-glucosyltransferase B3GLCT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acetylglucosaminyltransferase activity [GO:0008375] ADLQEILERE;GVSRKSDIDLKGIVFVI;TFHSFLPLCGNPV 3 8 0.99165 -0.18658 0 0 0 0 7.47946 0 0 0 10.9065 0 0 0 0 0 0 A0A8I3S1T5 A0A8I3S1T5_CANLF Deoxyribonuclease DNASE1L3 Canis lupus familiaris (Dog) (Canis familiaris) DNA catabolic process [GO:0006308] DNA nuclease activity [GO:0004536]; endonuclease activity [GO:0004519] LVSVKKYYLYHDY 1 4.7 0.9931 -0.17914 0 0 0 0 0 0 11.2568 0 0 0 0 0 0 0 0 A0A8I3S1U2 A0A8I3S1U2_CANLF Thiol methyltransferase 1A TMT1A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649] endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811] mRNA m(6)A methyltransferase activity [GO:0001734]; thiol S-methyltransferase activity [GO:0018708] PFWHLLFDRCHL 1 4.9 0.95211 0.05044 0 0 4.82817 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S1V3 A0A8I3S1V3_CANLF G-patch domain containing 2 like GPATCH2L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DFTHLAEHTCCYS;ENMSECETSSVC;LGELWEEMALSPRQQ 3 11.4 0.84982 0.17105 0 3.45352 7.67391 0 9.96058 0 7.99515 0 0 0 0 0 0 0 0 A0A8I3S1W2 A0A8I3S1W2_CANLF Actin related protein T3 ACTRT3 Canis lupus familiaris (Dog) (Canis familiaris) ITEVFFEHLQ;LFATGFTTGY 2 5.4 0.98967 -0.5168 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9056 0 A0A8I3S1W5 A0A8I3S1W5_CANLF BTB domain containing 10 BTBD10 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of phosphorylation [GO:0042327] cytoplasm [GO:0005737] AESLYTLISE;ALMHELSNDGARRQF;KIRLGIEGYPTYK;KTSGEMVFVYENA;NRDVAKSVLKERGLKKIRL;RCPDGISIPELR 6 16.1 1.0018 -1.3106 0 0 4.22574 8.58203 0 0 0 0 0 0 11.7269 0 12.0563 0 0 A0A8I3S1W7 A0A8I3S1W7_CANLF V-type proton ATPase subunit S1-like protein ATP6AP1L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTDDMSSLWEVT;LLPSDTDDMSSLW 2 4.9 0.99012 -0.21699 0 0 0 0 0 0 0 10.3078 10.7432 0 0 0 0 0 0 A0A8I3S1W8 A0A8I3S1W8_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP2CB Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression [GO:0010629]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to antibiotic [GO:0046677]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542] "chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; protein phosphatase type 2A complex [GO:0000159]; spindle pole [GO:0000922]" protein serine/threonine phosphatase activity [GO:0004722] EVRCPVTVCGDVHGQFHDLMELFR;TLCEKAKEIL 2 11 0.99978 -0.61146 0 0 0 0 0 0 0 0 0 0 4.41244 4.41846 0 0 9.25113 A0A8I3S1X1 A0A8I3S1X1_CANLF ELMO domain containing 2 ELMOD2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of defense response to virus [GO:0050688] GTPase activator activity [GO:0005096] ISLWEFFYGHFFRFWM;REKFHEKIKG 2 8.9 0.99434 -0.56222 2.75183 0 0 0 0 0 0 0 0 0 0 0 9.23443 0 8.49454 A0A8I3S1X3 A0A8I3S1X3_CANLF Thrombospondin type laminin G domain and EAR repeats TSPEAR Canis lupus familiaris (Dog) (Canis familiaris) regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; tooth mineralization [GO:0034505] ARFFIGSRKRTKGLF 1 2.2 0.98922 -0.26403 0 0 0 0 0 0 0 0 0 0 0 0 0 9.37599 0 A0A8I3S1Y2 A0A8I3S1Y2_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] EQLGNPYRLCGNERSK;GGGCSHEC;GGGGCSHE 3 26.9 1.003 -2.1593 0 5.51178 0 0 0 0 0 7.9037 0 0 6.76288 0 0 0 0 A0A8I3S1Y8 A0A8I3S1Y8_CANLF Prostate tumor-overexpressed gene 1 protein PTOV1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; transcription regulator complex [GO:0005667] AGCMLFPHISPCE;PQPPRIRARS 2 5.5 0.99707 -0.5932 0 0 0 0 0 0 8.65026 0 0 0 0 0 0 0 0 A0A8I3S1Z0 A0A8I3S1Z0_CANLF PLAG1 like zinc finger 2 PLAGL2 Canis lupus familiaris (Dog) (Canis familiaris) chylomicron assembly [GO:0034378]; lipid metabolic process [GO:0006629]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; post-embryonic development [GO:0009791] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]" ATGGLVMGYSQAEAQP 1 3.2 0.9868 -0.23485 0 0 0 9.55109 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S201 A0A8I3S201_CANLF UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) CMPK1 CMPK Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; UDP biosynthetic process [GO:0006225] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] (d)CMP kinase activity [GO:0004127]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; UMP kinase activity [GO:0033862] GPGAGKGTQCARIVEK 1 7 0.95614 0.049233 0 0 0 0 0 0 0 0 6.95012 0 0 0 0 0 0 A0A8I3S202 A0A8I3S202_CANLF Uncharacterized protein C24H20orf173 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824] HIYCGTCALMGHS;SLGSPLFL;VGERNRFATCYEKALEHLM;WTSDAPLEEAFN 4 14.3 0.99745 -0.10578 0 0 0 8.01965 5.65309 6.21093 0 11.0612 0 0 0 0 0 0 10.7592 A0A8I3S212 A0A8I3S212_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CCQQSSCQPYCCS;CQPSCCNSSPCQEDSCVSVCCK;PICCEASPCSASPCCQQSSCQ;QPSPCRPS 5 19.2 0.92812 0.10673 0 0 0 0 0 0 0 0 0 0 0 0 0 4.29182 6.86443 A0A8I3S217 A0A8I3S217_CANLF Forkhead box C1 FOXC1 Canis lupus familiaris (Dog) (Canis familiaris) cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; eye development [GO:0001654]; heart development [GO:0007507]; negative regulation of mitotic cell cycle [GO:0045930]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of keratinocyte differentiation [GO:0045618] cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654] "DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" DSYNMFENGSFLRRRRRFKKK;LALGAYSPGQGSL 2 6 0.99007 -0.20043 0 0 0 0 0 0 0 0 0 0 0 0 0 15.8642 0 A0A8I3S223 A0A8I3S223_CANLF Olfactory receptor OR51I1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGFDACLVQMFFIHTF 1 5.1 0.96346 0.049233 0 0 0 5.71647 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S234 A0A8I3S234_CANLF Regulator of G protein signaling 10 RGS10 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] cytosol [GO:0005829]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; synapse [GO:0045202] G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096] DIHSGDGS;SQVNVEGQSRLNEKILEEP 2 14.9 1.0039 -1.0549 7.43371 0 0 0 0 0 4.84358 5.58189 0 0 0 0 0 0 0 A0A8I3S246 A0A8I3S246_CANLF G protein-coupled receptor 15 GPR15 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; T cell migration [GO:0072678] endosome [GO:0005768]; external side of plasma membrane [GO:0009897] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; coreceptor activity [GO:0015026]; virus receptor activity [GO:0001618] KLRKSIKIIFIVVAAFVLSWLP 1 6.1 0.97314 0.046699 0 8.79028 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S248 A0A8I3S248_CANLF Protein RIC1 homolog RIC1 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; Golgi membrane [GO:0000139]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066] ETLLLSVF;EVRLKDLGCF;GAQLICTLGGDFAY;IAVVGKFGFAH;IDTASSHGPQMQDA;ISDRQEELRVYLR;LICTLGGD;QIREKDSNPNQRKL;QLHGVWPQD 9 7 0.99898 -2.9563 9.54759 0 11.3709 0 0 6.7807 9.54626 0 6.49514 0 0 0 0 0 0 A0A8I3S251 A0A8I3S251_CANLF Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) MFSD5 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] molybdate ion transmembrane transporter activity [GO:0015098] GQESPVESFIAFL;YFPSMSFLRR;YHFLEGQIAIL 3 7.6 0.98982 -0.51637 0 0 9.99166 0 0 0 0 0 10.2369 0 0 0 0 9.45358 0 A0A8I3S252 A0A8I3S252_CANLF peptidylprolyl isomerase (EC 5.2.1.8) LOC100686132 Canis lupus familiaris (Dog) (Canis familiaris) peptidyl-prolyl cis-trans isomerase activity [GO:0003755] DEALLTMSKGEKAQLET 1 9.1 0.98338 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 9.3555 0 0 A0A8I3S254 A0A8I3S254_CANLF Intraflagellar transport 140 IFT140 Canis lupus familiaris (Dog) (Canis familiaris) determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589] axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cone photoreceptor outer segment [GO:0120199]; intraciliary transport particle A [GO:0030991]; photoreceptor connecting cilium [GO:0032391] GMLEDAEQLYRKCGRYD;LSTGVTHS;VRPEGKAEEV 3 2.4 1.0027 -1.3749 0 0 0 8.41718 0 0 6.29974 0 0 0 0 0 0 0 0 A0A8I3S268 A0A8I3S268_CANLF PR domain zinc finger protein 12 (EC 2.1.1.-) (PR domain-containing protein 12) PRDM12 Canis lupus familiaris (Dog) (Canis familiaris) detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; methylation [GO:0032259]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection development [GO:0031175] nucleoplasm [GO:0005654] DNA binding [GO:0003677]; histone chaperone activity [GO:0140713]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] APEHVDICKNNNL 1 3.6 0.93818 0.072032 0 7.59066 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S275 A0A8I3S275_CANLF Adhesion G protein-coupled receptor E2 ADGRE2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AALTFLLCK;ATTCRCSPGFSSLSGE;GEIFSSPLESCDD;PGIKSQRLSNFFERVQELHRDFK;QDLIQEVDEL;QLSICLFLAHLLFLMAID;SLHLQLSICLFLAHLLF;TEIKVLCSI;VYVVGHTNQTSACILSTVPYH;YHCMCSPGYA 10 15.5 0.99506 -0.15866 6.27437 0 0 8.07548 0 0 0 0 0 0 0 3.3132 0 0 0 A0A8I3S282 A0A8I3S282_CANLF Glutathione-disulfide reductase GSR Canis lupus familiaris (Dog) (Canis familiaris) cell redox homeostasis [GO:0045454] "flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668]" AAGAAASFDYLV;AASFDYLVIG;RPQESQIP 3 5 1.0027 -1.1899 0 0 0 0 9.1152 0 0 0 0 0 0 0 0 0 10.8856 A0A8I3S288 A0A8I3S288_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) JOSD2 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] LFSQEAADEICKRP 1 9.6 0.93506 0.060938 0 0 0 0 8.59623 0 0 0 0 0 0 0 0 0 0 A0A8I3S293 A0A8I3S293_CANLF Small cysteine and glycine repeat containing 4 SCYGR4 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCCRRSCGCSSCGCSSCGC;CCGCGGCGGCSSGCGGCGGCGG;CCPCCSGCCG;CCPCCSGCCGCCCSVP;CCPCCSGCCGCCCSVPVVC;CCPCCSGCCGCCCSVPVVCCCR;CCSGCCGCCCS;CCSGCCGCCCSV;CCSGCCGCCCSVPV;CCSGCCGCCCSVPVVCC;CGCSSCGCGKGCCQQKCCQ;CGCSSCGCSSCGCGKG;CGCSSCGCSSCGCGKGCC;CGCSSCGCSSCGCGKGCCQQ;CGCSSCGCSSCGCGKGCCQQKCCQQ;CGGCGGCGG;CGGCGGCGGCGGCGGCGG;CGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGCGGCGGC;CGGCGGCGGCGGCGGCGGGCGS;CPCCSGCCGCCCS;CPCCSGCCGCCCSVP;CRCYRVNCCPCCSGCCGCC;CRCYRVNCCPCCSGCCGCCCSV;CSGCCGCCCSVP;CSGCCGCCCSVPVVCCC;GCCGCGGCGGCSSGCGGCGGCG;GCCGCGGCGGCSSGCGGCGGCGGCG;GCGGCGGCGGCGGC;GCGGCGGCGGCGGCGGCGG;GCGGCGGCGGCGGCGGCGGCGGC;GCGGCGGCGGCGGCGGCGGGCG;GCGGCGGCGGCGGCGGGCG;GCGGCGGCGGCGGGCGSCTT;GCSSCGCSSC;GCSSGCGG;GGCGGCGGC;GGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGCGG;GGCGGCGGCGGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGCGGG;GGCGGCGGCGGCGGCGGG;GGCGGCGGCGGCGGCGGGCGS;GGCGGCGGCGGCGGCGGGCGSCT;GGCGGCGGCGGCGGGCGSC;GGCGGCGGCGGGCGSCTT;GGCGGCSSGCGGCGGCGGCGG;GGCGGCSSGCGGCGGCGGCGGCG;GGCSSGCGGCGGCGGCGGCGGCG;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCG;MGCCGCGGCGGCSSGCGGCGG;MGCCGCGGCGGCSSGCGGCGGCG;NCCPCCSGCCG;NCCPCCSGCCGCC;NCCPCCSGCCGCCC;NCCPCCSGCCGCCCS;NCCPCCSGCCGCCCSVPVVCCC;NCCPCCSGCCGCCCSVPVVCCCRRS;PCCSGCCGCCCSVPVVCCC;RCYRVNCCPCCSGCCGCC;SCGCGKGC;SCGCSSCGCSSC;SCGCSSCGCSSCGCGKGCCQ;SGCCGCCCSVPVVCCCRRSC;SGCGGCGGCGGCGGCGGC;SGCGGCGGCGGCGGCGGCG;SGCGGCGGCGGCGGCGGCGGCGGC;SSCGCSSCGCG;SSGCGGCGGCGGCGGCGGC;SSGCGGCGGCGGCGGCGGCGGCG;SSGCGGCGGCGGCGGCGGCGGCGG;SSGCGGCGGCGGCGGCGGCGGCGGC;TTCRCYRVNCCPCCSGCCGCCC;VNCCPCCSGCCGC;VNCCPCCSGCCGCCCSVPVVCC 81 91.3 0.52571 0.45389 7.46263 9.80067 8.65914 5.95972 6.3117 8.61949 8.09038 8.13201 8.08183 7.00484 8.70698 9.22366 8.26191 9.19992 7.84298 A0A8I3S2A5 A0A8I3S2A5_CANLF "GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase)" GMDS Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673] "GDP-mannose 4,6-dehydratase activity [GO:0008446]" DLAEYTADVD;IVWEGKNENEVG;LLPPPPPPPSPLLPPSPPPPPP;LLPSPPPPLPPPSPSSSLPPPSSS;NTAEDKRPERC;QLECFSLGNLDAKRDWGH 6 15.1 1.0016 -0.69993 0 0 5.63854 8.05202 0 0 0 0 10.1807 0 6.23774 0 3.38805 0 9.39926 A0A8I3S2B4 A0A8I3S2B4_CANLF BarH like homeobox 1 BARHL1 Canis lupus familiaris (Dog) (Canis familiaris) midbrain development [GO:0030901]; negative regulation of outer hair cell apoptotic process [GO:1905586]; neuron migration [GO:0001764]; outer hair cell apoptotic process [GO:1905584]; sensory perception of sound [GO:0007605] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific double-stranded DNA binding [GO:1990837]" EAGNYSALQRMFPSPY 1 4.9 0.96048 0.049233 0 0 0 0 0 0 0 0 0 8.23845 0 0 0 0 0 A0A8I3S2C3 A0A8I3S2C3_CANLF Cilia and flagella associated protein 77 CFAP77 Canis lupus familiaris (Dog) (Canis familiaris) axonemal B tubule inner sheath [GO:0160112] NFLYRQLNDMRISD 1 3.6 0.94057 0.060769 0 0 0 0 0 0 0 0 0 7.19672 0 0 0 0 0 A0A8I3S2C4 A0A8I3S2C4_CANLF Acyl-coenzyme A oxidase ACOX1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540] peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504] EAYKLRAAR;HLRPDGNGPRFVHRGR;LETTATYD;NAAIEACRMACGGHGY;NVYEHLFEWAKKSPL;PLLATAYAFQFV;PPFEILHLNIKA;VSYLNDLPTQ 8 14.7 1.0033 -1.3354 0 8.17597 0 0 0 0 11.31 9.98028 10.0095 0 0 9.20193 0 8.87646 10.993 A0A8I3S2C5 A0A8I3S2C5_CANLF HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 HERC6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ubiquitin-protein transferase activity [GO:0004842] AVYEEFQRGFYK;LLLSNGQVHSCGDNGRGQL;QEILDNEADDTEEL 3 4.7 0.99746 -0.10701 0 0 0 9.716 0 0 0 5.86666 0 0 0 0 0 0 0 A0A8I3S2E3 A0A8I3S2E3_CANLF Neurogenic differentiation factor NEUROD6 Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564]; dentate gyrus development [GO:0021542]; sensory organ development [GO:0007423] nucleus [GO:0005634] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]" KEEEEEDRE;RGLRKKKTTKLRLERVKFRRQEA 2 9.5 0.9918 -0.20827 7.19426 0 0 10.4586 0 0 0 0 0 0 0 2.86877 0 0 0 A0A8I3S2E5 A0A8I3S2E5_CANLF Outer dense fiber of sperm tails 2 like ODF2L Canis lupus familiaris (Dog) (Canis familiaris) ENNLITKNKNKKLEKVDAN;ESHLSCLKQDRLNEE;QELSCLFQ 3 7.7 0.98729 -0.40639 0 0 0 0 7.71761 0 0 0 7.24802 0 0 0 0 0 0 A0A8I3S2E8 A0A8I3S2E8_CANLF "Arachidonate 12-lipoxygenase, 12S type" ALOX12 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; establishment of skin barrier [GO:0061436]; fatty acid oxidation [GO:0019395]; leukotriene A4 metabolic process [GO:1901751]; linoleic acid metabolic process [GO:0043651]; lipoxin A4 biosynthetic process [GO:2001303]; lipoxin B4 biosynthetic process [GO:2001306]; lipoxygenase pathway [GO:0019372]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of platelet aggregation [GO:0090331] cytosol [GO:0005829]; sarcolemma [GO:0042383] arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 15-lipoxygenase activity [GO:0050473]; iron ion binding [GO:0005506]; linoleate 13S-lipoxygenase activity [GO:0016165] PGASEEAAFPCYQW;VFQKHREKELK;YTLLSSWN 3 5 1.0012 -0.7067 0 0 0 0 0 0 6.53155 0 12.3857 0 0 0 0 0 0 A0A8I3S2F1 A0A8I3S2F1_CANLF SHC adaptor protein 4 SHC4 Canis lupus familiaris (Dog) (Canis familiaris) FNDPCYIN;NDPCYINTQAFQSTLGS;SPWHREKAPETVQP;VLGSPWHREKAPETVQPG 4 10.5 1.0024 -0.76481 0 0 0 10.3471 11.2302 0 0 0 0 0 0 0 0 2.74502 0 A0A8I3S2F6 A0A8I3S2F6_CANLF Small cysteine and glycine repeat containing 8 SCYGR8 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCCRRSCGCSSCGCSSCGC;CCPCCSGCCG;CCPCCSGCCGCCCSVP;CCPCCSGCCGCCCSVPVVC;CCPCCSGCCGCCCSVPVVCCCR;CCSGCCGCCCS;CCSGCCGCCCSV;CCSGCCGCCCSVPV;CCSGCCGCCCSVPVVCC;CGCSSCGCGKGCCQQKCCQ;CGCSSCGCSSCGCGKG;CGCSSCGCSSCGCGKGCC;CGCSSCGCSSCGCGKGCCQQ;CGCSSCGCSSCGCGKGCCQQKCCQQ;CGGCGGCGG;CGGCGGCGGCGGCGGCGG;CGGCGGCGGCGGCGGCGGSCT;CPCCSGCCGCCCS;CPCCSGCCGCCCSVP;CRCYRVNCCPCCSGCCGCC;CRCYRVNCCPCCSGCCGCCCSV;CSGCCGCCCSVP;CSGCCGCCCSVPVVCCC;CSSCGGCGGCGGCGGCGG;CSSCGGCGGCGGCGGCGGCGGSCT;GCCGCGGCGGCSSGCGGCGGCSSC;GCGGCGGCGGCGGC;GCGGCSSCGGCGGCGGCGGCGG;GCGGCSSCGGCGGCGGCGGCGGC;GCSSCGCSSC;GCSSCGGC;GCSSCGGCGGCGGCGGCGGC;GCSSCGGCGGCGGCGGCGGCGGSCT;GCSSGCGG;GGCGGCGGC;GGCGGCGGCGGCGGC;GGCGGCGGCGGCGGCGGSCT;GGCGGCGGCGGCGGCGGSCTTC;GGCSSCGGCGGCGGCGGCGGCGGS;GGSCTTCRCYRVNCCPCCSGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCG;MGCCGCGGCGGCSSGCGGCGG;NCCPCCSGCCG;NCCPCCSGCCGCC;NCCPCCSGCCGCCC;NCCPCCSGCCGCCCS;NCCPCCSGCCGCCCSVPVVCCC;NCCPCCSGCCGCCCSVPVVCCCRRS;PCCSGCCGCCCSVPVVCCC;RCYRVNCCPCCSGCCGCC;SCGCGKGC;SCGCSSCGCSSC;SCGCSSCGCSSCGCGKGCCQ;SCGGCGGCGGCGGC;SCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGG;SCGGCGGCGGCGGCGGCGGSCT;SCGGCGGCGGCGGCGGCGGSCTTC;SGCCGCCCSVPVVCCCRRSC;SGCGGCGGCSSCGGCGGC;SGCGGCGGCSSCGGCGGCG;SGCGGCGGCSSCGGCGGCGG;SGCGGCGGCSSCGGCGGCGGCGGCG;SSCGCSSCGCG;SSCGGCGGCGGCGGCGGC;SSCGGCGGCGGCGGCGGCGGSCTT;SSCGGCGGCGGCGGCGGCGGSCTTC;SSGCGGCGGCSSCGGCGGC;TTCRCYRVNCCPCCSGCCGCCC;VNCCPCCSGCCGC;VNCCPCCSGCCGCCCSVPVVCC 75 91.1 0.8722 0.14216 5.41071 5.72268 8.05268 7.32112 6.06779 8.3546 3.5623 9.58716 8.65996 0 9.53959 10.4481 5.73815 7.88472 5.53736 A0A8I3S2G0 A0A8I3S2G0_CANLF IZUMO family member 3 IZUMO3 Canis lupus familiaris (Dog) (Canis familiaris) AVQKVTKLRT;EDIRSLLAKLIP;KAIRRSLKKYLEKKL;YCGEEDSRKAENR 4 21.4 0.98654 -0.42526 0 0 0 13.2658 0 4.44016 0 10.2004 0 0 0 6.22358 0 0 9.49635 A0A8I3S2G7 A0A8I3S2G7_CANLF IRF tryptophan pentad repeat domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] LIFKAWAVARGRWPPG 1 8.8 0.96432 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 3.55459 0 0 A0A8I3S2I3 A0A8I3S2I3_CANLF IQ motif containing H IQCH Canis lupus familiaris (Dog) (Canis familiaris) IDQKSFVFPLESEGKLW;MQLGRLCDILDANV;PKIKVKVQKLIK;PVEATKFSPKKRRSQG;TFARNLFIIH;YFTPIPVP 6 7.5 0.9538 0.05044 0 0 0 6.18919 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S2I7 A0A8I3S2I7_CANLF ITPR interacting domain containing 1 ITPRID1 Canis lupus familiaris (Dog) (Canis familiaris) signaling receptor binding [GO:0005102] AEHSSLQTCDDLV;DISKPSNVLSYTVDNIQ;HCCVCCHHHPHC;HTVPAHCC;IPQSIPEWLEFWEKDPVEI;IWEEKASISMVEKES;TVSLHEQGM 7 9.1 1.0018 -0.68223 0 0 0 0 0 0 0 11.7584 10.8431 0 0 0 11.0094 0 11.9748 A0A8I3S2J6 A0A8I3S2J6_CANLF Acid ceramidase (EC 3.5.1.23) ASAH1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631]; sphingolipid metabolic process [GO:0006665] extracellular region [GO:0005576]; lysosome [GO:0005764] fatty acid amide hydrolase activity [GO:0017064] FAGYVGMLTGFKPG;KDAMWIGF;LFSLTLNERFSINGGY;QENISFATMYDV 4 13.7 1.0027 -1.1979 0 0 10.3197 0 0 0 0 0 10.883 0 0 0 0 11.0766 9.08799 A0A8I3S2K3 A0A8I3S2K3_CANLF Dickkopf WNT signaling pathway inhibitor 3 DKK3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178] extracellular region [GO:0005576] EELIDTTAFQ;VEELMEDTQHKL;VPREAPSEY 3 9.3 1.0023 -1.0186 0 0 0 0 0 0 8.53349 11.2248 0 0 0 0 0 0 3.80952 A0A8I3S2K4 A0A8I3S2K4_CANLF Coiled-coil domain containing 82 CCDC82 Canis lupus familiaris (Dog) (Canis familiaris) DDEEEDDYEYDEDGDDYI;DENDDEEEDDYEYDEDGD;DENDDEEEDDYEYDEDGDD;EDSEKESCPRNDEND;EEDDYEYDEDGDDYIID;ENDDEEEDDYEYD;ENDDEEEDDYEYDED;ENDDEEEDDYEYDEDG;ENDDEEEDDYEYDEDGDD;ENDDEEEDDYEYDEDGDDYI;FDSNEELDSDEELDSN;LVRKVGVKRPRR;SCPRNDENDDEEEDDY;VRKVGVKRPRRV 14 12.3 0.64315 0.32951 2.87358 4.801 9.12029 7.97825 0 0 0 10.4184 10.1126 7.02536 3.46923 0 12.3214 10.9201 12.0405 A0A8I3S2L1 A0A8I3S2L1_CANLF Glutathione peroxidase GPX6 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] peroxidase activity [GO:0004601] LVGPDGVPVMRWFHQAPV 1 8.2 0.98815 -0.22585 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1135 0 A0A8I3S2L4 A0A8I3S2L4_CANLF MHC class Ib DLA-79 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DLRSWIVEDPVAQ;HWAVAYVDDTPLERFDSEREGRRP;LLLLLLLL;LLLLLLLLL;SIIAGLVLLVITGAMLVGVVIW;TLLLLLLL 6 18.2 0.99229 -0.291 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.72809 A0A8I3S2L6 A0A8I3S2L6_CANLF Myosin VIIB MYO7B Canis lupus familiaris (Dog) (Canis familiaris) apical cytoplasm [GO:0090651]; brush border [GO:0005903]; microvillus [GO:0005902]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AILHLGNV;AWTSVELADQIFSLALQ;DLLILTKKQGL;DTTILPFKK;FGKYIDIHFNPNGV;GTPSEYHYLTTG;GVWSGEYNFEKEDDLV;KGIYGHLFLWIVK;KSQSILPTRKR;LIYKAQFDNNRS;NRHGVLLIHPKTKELLTT;RSSKITSQVTSQLNIGEEA;TEPPTWLELQ 13 7.9 1.0034 -2.0527 0 11.2744 5.75069 0 8.20989 5.13381 11.0811 9.28695 12.0735 3.06159 5.42203 0 10.443 0 7.84122 A0A8I3S2M4 A0A8I3S2M4_CANLF Mitochondrial ribosomal protein S18C MRPS18C Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VLWRSCSQYEQVASNEDLLLSQFI 1 20.9 0.99346 -0.28407 0 0 0 0 0 0 16.4954 0 0 0 0 0 0 0 0 A0A8I3S2M7 A0A8I3S2M7_CANLF U2 small nuclear RNA auxiliary factor 1 U2AF1 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; U2AF complex [GO:0089701] metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; RS domain binding [GO:0050733] DKVNCSFYFKI;GGGGGGGG;IYRNPQNSSQSAD;VGNVYVKFRREED 4 20.4 0.98945 -0.21658 0 0 9.57684 0 0 0 0 0 0 9.1471 0 0 0 0 0 A0A8I3S2N0 A0A8I3S2N0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GSGYGCGCGYGSGYGCGCG;GYGYGCGP;RTGYGCGYGCGYGSGYGCGCGYGSG;SGYGCGCGYGSGCWG 4 56.1 0.93681 0.089412 6.67469 0 0 0 0 0 0 0 0 0 4.50608 0 0 0 0 A0A8I3S2N2 A0A8I3S2N2_CANLF Protein arginine methyltransferase 3 PRMT3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053] cytosol [GO:0005829]; extracellular matrix [GO:0031012] metal ion binding [GO:0046872]; protein-arginine N-methyltransferase activity [GO:0016274]; ribosome binding [GO:0043022] NCHSRVVFSTGP;PSAHTLFP 2 3.3 1.0046 -1.1044 0 0 0 8.27212 0 0 0 0 0 8.04996 0 0 2.29514 7.95797 0 A0A8I3S2N4 A0A8I3S2N4_CANLF Potassium voltage-gated channel interacting protein 2 KCNIP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of potassium ion transmembrane transport [GO:1901379] voltage-gated potassium channel complex [GO:0008076] calcium ion binding [GO:0005509]; potassium channel regulator activity [GO:0015459] PPGPTKKA 1 3.2 0.98986 -0.26592 0 0 0 0 0 0 0 0 0 0 0 6.59009 0 0 0 A0A8I3S2P3 A0A8I3S2P3_CANLF Smoothelin SMTN Canis lupus familiaris (Dog) (Canis familiaris) ADLAGSRPCQRSL;AGRAAVTQAAEAAASAMEPVARAA;LEQCEVPEQEKQE;RPLAQLQS;TSSGGKSTI 5 6.2 0.99116 -0.22184 10.3376 10.3289 0 0 0 0 10.5986 11.3292 10.3796 0 8.48357 0 7.32562 0 0 A0A8I3S2P6 A0A8I3S2P6_CANLF Olfactory receptor OR6C75C Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIIFPPVILVLK 1 3.8 0.94767 0.05044 0 0 0 6.10587 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S2Q2 A0A8I3S2Q2_CANLF Rab-GAP TBC domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PDLAGPLQP;TFLPLGPGAT;VGPPRGHSQAPDLP;VLMFLPEEDASWVLAQL 4 10.4 1.0024 -1.1517 0 0 0 0 0 0 0 11.9505 0 10.2836 10.6497 0 0 0 0 A0A8I3S2R8 A0A8I3S2R8_CANLF Olfactory receptor OR4K6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DIYVLGIFMIST;IYVLGIFMISTSG;PHLHSPMY 3 6.9 0.99424 -0.056198 0 0 0 0 0 0 0 0 0 0 0 8.71651 0 0 13.978 A0A8I3S2T7 A0A8I3S2T7_CANLF Bone morphogenetic protein 6 BMP6 Canis lupus familiaris (Dog) (Canis familiaris) BMP signaling pathway [GO:0030509] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; growth factor activity [GO:0008083] AAAAAAAVLLRLLHLLLLLL;AAAAAVLLRLLHLLLLLL;AAAAVLLRLLHLLLLL;AAAAVLLRLLHLLLLLLR;AAAVLLRLLHLLLLLL;AVLLRLLHLLLLLLRL;AVLLRLLHLLLLLLRLP;LLHLLLLLLRLPLP;RRRRRRRRVRTDQRA;VLLRLLHLLLLLLRLPLP;WWWGLLCSC 11 10.7 0.86059 0.16296 0 0 0 5.39657 9.02763 5.47024 0 6.66519 7.25408 6.93522 0 0 0 4.80405 7.10434 A0A8I3S2T8 A0A8I3S2T8_CANLF Probable inactive allantoicase (Allantoate amidinohydrolase) ALLC Canis lupus familiaris (Dog) (Canis familiaris) allantoin catabolic process [GO:0000256] allantoicase activity [GO:0004037] EEEDMIKQKWE;EPFDLVAIAH;SESVGGQVLFATDDFFAPA;VPMTELKPGKPA 4 12.6 0.99533 -0.01201 0 0 0 9.12482 0 0 0 0 0 5.43039 0 0 0 5.43713 8.67564 A0A8I3S2U0 A0A8I3S2U0_CANLF Zinc finger and BTB domain containing 7C LOC119872627 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285] DDKEDDDDEDEDED;DKEDDDDEDEDEDEEDEEEE;DLGLLRPRCPIFLVL;EDDKEDDDDEDEDEDEEDEEE;EDEEEEEEEEEDEEDEEDD;EEEEEEDEEDEEDDTEDFADQ;EEEEEEEDEEDEEDDTED;EEEEEEEEEDEEDEEDDTEDFA;EPGGDGGE;GVRPYQCEFCYKSFTRSDHLHRHIK;SDFFKDMFPDLPG;TSTLTITA 12 15.8 1.0029 -2.3554 7.49281 0 9.8208 4.29315 0 7.84065 0 5.92084 8.99087 0 9.35768 6.75782 0 7.38793 5.60949 A0A8I3S2U5 A0A8I3S2U5_CANLF Phospholipid scramblase PLSCR3 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128] GHVLQTWHPFLPKFSIQDA;LGATFLIDYM;SPGPAAPG;VGPCWTCGCGSDTNFEVK 4 18.5 1.0033 -1.6179 0 0 0 8.87854 0 0 6.66874 10.1187 0 10.3682 0 0 9.13999 0 0 A0A8I3S2V1 A0A8I3S2V1_CANLF Monoglyceride lipase MGLL Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol metabolic process [GO:0006639] membrane [GO:0016020] acylglycerol lipase activity [GO:0047372] GERMVVSDFHVFIRDVLQHVDFMQK;MWVSQRIGAAAGTGSP;TGPEDPFRMPEES 3 19 0.99093 -0.18599 0 0 0 0 0 0 9.66899 0 10.2957 0 7.73145 0 0 0 0 A0A8I3S2W9 A0A8I3S2W9_CANLF Secreted frizzled related protein 4 SFRP4 Canis lupus familiaris (Dog) (Canis familiaris) bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of sodium-dependent phosphate transport [GO:2000119]; phosphate ion homeostasis [GO:0055062]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of receptor internalization [GO:0002092]; Wnt signaling pathway [GO:0016055] cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] Wnt-protein binding [GO:0017147] GVRGAPCEAVRIPMCRH;LPDDVKWIDITPDMM;NTPKPKGKPPAPKPASPKKTIKAR;PIPRTQVPLITN;QCPHILPHQDVLIMCYEWRSR;RGVCISPEAIV;STQENAVLAIEQYEELV 7 33.7 0.63362 0.34464 9.07946 0 0 8.72847 0 10.3888 9.33224 0 9.88101 0 0 6.95431 9.61673 8.73495 0 A0A8I3S2Y2 A0A8I3S2Y2_CANLF Tyrosine-protein kinase (EC 2.7.10.2) FYN Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; innate immune response [GO:0045087]; T cell receptor signaling pathway [GO:0050852] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; signaling receptor binding [GO:0005102] PVDSIQAEEW;VQHYSDKADGLCFNLTVIAS 2 5.6 0.98415 -0.24332 0 0 9.51718 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S2Y6 A0A8I3S2Y6_CANLF Ig-like domain-containing protein CD300E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLDVLGPG;FEAPSKTTERTT;IVETKGKEKEERSGRV;LVFLKLPLFLTLVGAVLWV;TADDAGSYW 5 26.4 1.0025 -1.7594 0 0 0 0 0 0 0 9.01078 0 8.50974 9.37712 0 9.87175 6.85087 0 A0A8I3S2Y9 A0A8I3S2Y9_CANLF Olfactory receptor OR2AD2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALGVILLLIPLSLILISYAVITQAV;LGVILLLIPLSLILIS;VILLLIPLSLILISYAVITQA 3 8 0.99599 -0.18999 5.93097 0 0 0 0 0 0 0 6.40869 0 9.824 0 0 0 0 A0A8I3S2Z0 A0A8I3S2Z0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] IAKRKKKKKKR;IAKRKKKKKKRK;IAKRKKKKKKRKEMKKRV;LEIRKVEKRKRK;MEKRRNVEIKKRLEIRKVEKRK 5 14.9 0.99113 -0.13741 0 0 0 0 0 4.5897 4.59956 0 0 4.82263 6.0433 0 0 0 5.61806 A0A8I3S308 A0A8I3S308_CANLF Pre-mRNA-processing factor 19 (EC 2.3.2.27) PRPF19 Canis lupus familiaris (Dog) (Canis familiaris) "DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; protein K63-linked ubiquitination [GO:0070534]" cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006] ubiquitin protein ligase activity [GO:0061630] DVQIYICKQWTEILHF 1 3.2 0.95642 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 8.85568 0 A0A8I3S312 A0A8I3S312_CANLF MKS transition zone complex subunit 1 MKS1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] PTASGHRSEEEEE;QPEEEEREQRVFKDLYGRHKEY 2 7.7 0.9895 -0.53088 0 0 0 0 0 0 11.5338 0 0 0 0 0 10.1438 0 0 A0A8I3S321 A0A8I3S321_CANLF MAGE domain-containing protein LOC119868247 Canis lupus familiaris (Dog) (Canis familiaris) GQPEPPGPSGP;RLVFGLDVI 2 6 0.98953 -0.22243 0 0 0 0 0 0 0 0 0 0 0 12.0988 0 0 0 A0A8I3S329 A0A8I3S329_CANLF Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) C1GALT1 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] membrane [GO:0016020] glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity [GO:0016263]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] ADDDTYVILDNLR;KSWVNFLTFLCG 2 7.2 0.9919 -0.20701 0 0 0 0 0 0 10.4552 10.9115 0 0 0 0 0 0 0 A0A8I3S343 A0A8I3S343_CANLF Eukaryotic translation initiation factor 5 EIF5 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; ribosome assembly [GO:0042255] cytosol [GO:0005829]; plasma membrane [GO:0005886]; synapse [GO:0045202] eukaryotic initiation factor eIF2 binding [GO:0071074]; GDP-dissociation inhibitor activity [GO:0005092]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743] AAEEEEDDDWGEDTTEEA;GIIDSSDKEIVAE;LTEVLFNEKIREQIKKYRRHFLRFC;TGKKEKEKK;TQFDVKNDRYIVNGSHEANK 5 19.8 0.99329 -0.28621 0 6.24891 0 0 0 0 7.4287 11.06 0 0 0 10.047 0 0 7.04603 A0A8I3S353 A0A8I3S353_CANLF Dendrin DDN Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DSVRDILDVISRTEEA;PSAQPQSDPGA 2 3.8 0.94842 0.084724 0 0 8.61162 0 6.06454 0 0 0 0 0 0 0 0 0 0 A0A8I3S362 A0A8I3S362_CANLF "Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein" RRP9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] U3 snoRNA binding [GO:0034511] GDFLVAGVGQEHR;GVEGQPPS;RKLHVIPRAKKGVE;SVALWGLSKKRPL 4 9.8 1.0017 -1.251 8.34886 0 8.122 0 0 0 0 0 10.1649 0 0 0 0 7.87909 0 A0A8I3S369 A0A8I3S369_CANLF U6 snRNA-associated Sm-like protein LSm4 LSM4 Canis lupus familiaris (Dog) (Canis familiaris) nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; spliceosomal snRNP assembly [GO:0000387] P-body [GO:0000932]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U6 snRNP [GO:0005688] U6 snRNA binding [GO:0017070] IPDEIIDMVKEEVVAKG 1 13.6 0.97667 0.046227 0 0 0 0 0 0 7.2318 0 0 0 0 0 0 0 0 A0A8I3S383 A0A8I3S383_CANLF Transcriptional adapter 3 (ADA3 homolog) (Transcriptional adapter 3-like) Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] MGPLSQLHTKD 1 3.2 0.98373 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.13827 A0A8I3S384 A0A8I3S384_CANLF Phosphodiesterase (EC 3.1.4.-) PDE7A Canis lupus familiaris (Dog) (Canis familiaris) cAMP-mediated signaling [GO:0019933] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]" SERRGSHPYIDFR 1 2.8 0.99109 -0.26943 0 0 0 8.0427 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S3B0 A0A8I3S3B0_CANLF Nucleotide exchange factor SIL1 SIL1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] adenyl-nucleotide exchange factor activity [GO:0000774]; identical protein binding [GO:0042802] AKVKRLFR;RCPSNSTLNQLQ;VLEVFHPTYEWQAL;VLEVFHPTYEWQALRP 4 6.3 1.0019 -1.3057 0 0 8.99949 0 0 0 9.67243 0 0 4.19093 0 0 0 0 0 A0A8I3S3B4 A0A8I3S3B4_CANLF IQ motif containing N IQCN Canis lupus familiaris (Dog) (Canis familiaris) GTPSTSQRSGTTHKASHVSLYPSS;GVASNPQAPEF;LVEKKVSMEEGDIP;PGALFRGMAA;PQPCPVPTVTIAKT;PQTYPAAAMTKTP;QSLPPGPV;QTVAIRLPCPVSLDTKCHPCLL;SGVAPSLPPG;SLKTQTQAHMEAEVLKA;TEVGPGFSWASVPN;TPGPLRAASMSKMS;VAPSLTQLSVTSGVTPSL;VTSGVTPSLAQASMTDGVT 14 6.4 0.94774 0.04956 0 0 0 7.93516 0 8.64479 0 0 0 0 0 0 0 0 0 A0A8I3S3B6 A0A8I3S3B6_CANLF Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3) SLC46A3 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]" lysosomal membrane [GO:0005765] copper ion transmembrane transporter activity [GO:0005375] TLTSPLTTQ 1 2 1.0045 -0.80421 0 0 0 0 0 8.59492 0 0 0 0 0 0 0 0 0 A0A8I3S3B7 A0A8I3S3B7_CANLF Inducible T-cell costimulator ICOS Canis lupus familiaris (Dog) (Canis familiaris) T cell costimulation [GO:0031295] membrane [GO:0016020] DLTTTKEN;LDSSHASYYACQ 2 11.9 0.99332 -0.17468 0 0 0 0 0 6.93628 0 0 0 9.75542 0 0 0 0 0 A0A8I3S3C0 A0A8I3S3C0_CANLF RNA binding motif protein 39 RBM39 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446] ALAAAASV 1 1.6 0.99011 -0.26592 0 0 0 0 0 0 0 0 0 0 0 11.1909 0 0 0 A0A8I3S3C4 A0A8I3S3C4_CANLF Uncharacterized protein WDR75 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364] nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RNA binding [GO:0003723] GVFVPRDVPESFTSEA;SELIQLPLTENI;VKVHSTATEECVHVLQGHRNLVTGI 3 6.4 0.99295 -0.17883 0 0 0 0 0 0 0 7.74685 8.6226 0 0 0 0 0 0 A0A8I3S3D6 A0A8I3S3D6_CANLF Extracellular calcium-sensing receptor CASR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872] EPTCCFECVECPDGEY;IEGEPTCCFECVECPDGEY;KATNRELSYLLLFSLLCCFSS;PQDWTCRLRQPAFGIS;QDLKSRPESVECIRY 5 7.1 0.99348 -0.048025 0 0 0 0 0 0 8.02829 9.90758 7.64847 5.16864 0 0 0 6.68958 0 A0A8I3S3D8 A0A8I3S3D8_CANLF T cell receptor beta variable 30 TRBV30 Canis lupus familiaris (Dog) (Canis familiaris) IVPETPHNFTASRPQNG;SLSVTQIVPE 2 15.5 0.98967 -0.2156 9.9546 0 9.432 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S3F5 A0A8I3S3F5_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4C Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; signal transduction [GO:0007165] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]" DHPGVSNQFL;ELTLEEAEEEEEEEG;LDQLETLQTRHSVG;TDRIMAEFFQQGDRER;TLQTRHSVGEMA;VARPPKHLWRQPRRPIRIQQRFY 6 11.2 0.9872 -0.40613 0 9.11917 0 0 5.6579 3.21722 0 0 0 0 0 0 0 0 0 A0A8I3S3F8 A0A8I3S3F8_CANLF TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) TBP Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] nucleus [GO:0005634] DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251] LVLTHQQFSRP 1 3.5 0.98905 -0.19891 0 0 0 8.54234 0 0 0 0 0 0 0 0 0 8.18537 0 A0A8I3S3G2 A0A8I3S3G2_CANLF DNA replication complex GINS protein PSF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] GINS complex [GO:0000811] EGLDISQDMKPP;LDISQDMK;LGGDEGLDISQDMKPP;LPAFNEDELRQ;RSLGGDEGLDISQDMKPPKSL;SQDMKPPKS 6 24.4 1.0031 -1.6676 0 10.1949 0 0 0 9.00003 7.60696 0 0 0 0 0 11.2304 0 0 A0A8I3S3H5 A0A8I3S3H5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] cysteine-type peptidase activity [GO:0008234] VDCYQAQGN;YKPECSAKVL 2 7.5 1.0019 -1.4157 0 0 0 7.13638 0 0 0 0 0 0 0 0 0 10.1619 0 A0A8I3S3H8 A0A8I3S3H8_CANLF Kinase D interacting substrate 220 KIDINS220 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAGRGHADIVHLLL;PRDQSNGLGSGP 2 1.6 0.98943 -0.21622 0 0 0 0 5.41014 8.42966 0 0 0 0 0 0 0 0 0 A0A8I3S3I2 A0A8I3S3I2_CANLF "FERM, ARH/RhoGEF and pleckstrin domain protein 2" FARP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] AVFFSRGSS;DISFFAGGSEAFSF;DISFFAGGSEAFSFPYC;FKRKRFLIKLHPEVRGP;FQLCDIIDQLEQLSYP;NWSRVRKLSFKRKRFLIK;RQGGAGGP 7 10 1.0021 -1.4522 6.27167 9.63845 0 0 0 12.0112 12.5728 8.65288 0 0 0 0 0 0 9.84869 A0A8I3S3I3 A0A8I3S3I3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EDSPNKLYMLVT;HGVGFKKP 2 17.2 1.004 -1.0539 0 0 0 0 0 0 0 5.78291 0 0 0 0 0 6.70487 0 A0A8I3S3J7 A0A8I3S3J7_CANLF Large tumor suppressor kinase 1 LATS1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic sequestering of protein [GO:0051220]; G2/M transition of mitotic cell cycle [GO:0000086]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; keratinocyte differentiation [GO:0030216]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; regulation of actin filament polymerization [GO:0030833]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; sister chromatid segregation [GO:0000819] spindle pole [GO:0000922] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; nuclear estrogen receptor binding [GO:0030331]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674] EDDQHTGS;KAERDILAEADNEWVVRLYYSFQ;VNRQPPPPYPLTPTN;YIAPEVLLRTGYTQLCDWWSVGVIL 4 6.3 0.98704 -0.40682 0 11.4011 11.494 7.11228 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S3J9 A0A8I3S3J9_CANLF Tetratricopeptide repeat domain 14 TTC14 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] AEKLRKLLKEEKRLKKKRRKST;ETEVNYEEDIKTEVPETD;GVISSEELPLYYR;IETSAEKLRKLLKEEKRLKKKRR;ISSEELPLYYRRSVE;KLLKEEKRLKKKRRKS;KLRKLLKEEKRLKKKR;KQEVEKLLEKQD;VSSADESD;YGYRRFEKNTEGKKE 10 12.5 1.0022 -1.3012 5.19484 9.80187 0 5.06419 9.08868 0 0 11.3669 9.15383 0 0 0 4.75638 0 0 A0A8I3S3K0 A0A8I3S3K0_CANLF P2X purinoceptor P2RX6 Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; receptor complex [GO:0043235] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] AAAGGVFE;LANCWADEDCPEG;TFLCDLLLLYVDEEAH;VLEGTQSGNQTPT;VRVHWDCDLD;YVDEEAHFYWSTKY 6 15.9 1.0013 -0.94655 7.17712 0 0 0 0 10.2765 0 9.53249 0 0 0 0 9.1385 8.52403 0 A0A8I3S3K7 A0A8I3S3K7_CANLF SOS Ras/Rac guanine nucleotide exchange factor 1 SOS1 Canis lupus familiaris (Dog) (Canis familiaris) Ras protein signal transduction [GO:0007265] plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085]; protein heterodimerization activity [GO:0046982] KRRLSESACRFYSQ;QLSKPGAALYLQSIG;RSTLERMLDVTMLQEEKEEQMRL;TFLTTYRSFCK;TYYDLVKAFMA;YKREHTHPSVHRDGPPLLENAHS 6 8 0.98704 -0.40654 11.5536 0 0 0 0 0 11.2768 0 7.8913 0 0 0 0 10.2475 0 A0A8I3S3L8 A0A8I3S3L8_CANLF Armadillo repeat containing 6 ARMC6 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic progenitor cell differentiation [GO:0002244] cytosol [GO:0005829] DLRESVAHSRPQEVSMHLARFFEQ;VIMEGGGA 2 6.7 1.0036 -1.0631 0 6.66676 0 0 0 0 0 0 11.625 0 0 0 0 0 9.51564 A0A8I3S3M7 A0A8I3S3M7_CANLF Retrotransposon Gag like 4 RTL4 Canis lupus familiaris (Dog) (Canis familiaris) cognition [GO:0050890]; norepinephrine metabolic process [GO:0042415] nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GQVMPTLTTPV;MPTLTTPVMSVTCL 2 5.6 0.98731 -0.26015 0 0 0 0 0 0 0 0 0 8.2521 0 0 0 0 0 A0A8I3S3N1 A0A8I3S3N1_CANLF Large ribosomal subunit protein eL29 (60S ribosomal protein L29) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EVQDQGLNKTQ;EVQDQGLNKTQTT;PSHKDMNLGRA;QGLRALESEVQ 4 15 0.99662 -0.10979 9.87435 0 0 0 0 8.70487 0 0 0 10.4671 0 0 0 0 8.02481 A0A8I3S3N3 A0A8I3S3N3_CANLF Angiopoietin like 6 ANGPTL6 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;GGHYRSRYQDGV;GPSPGLEPSL;GVHSGYEFRTLGTGRRTLLP;LEPESDYYRLRLGQY;VSLSPVSTPISL 6 10.9 0.031579 1.1151 0 13.6319 12.8012 12.7011 12.7302 0 14.3801 14.7159 14.001 14.2255 0 14.488 7.65198 13.6518 12.8597 A0A8I3S3N5 A0A8I3S3N5_CANLF Matrix metallopeptidase 24 MMP24 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; collagen catabolic process [GO:0030574]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; extracellular matrix organization [GO:0030198]; glial cell differentiation [GO:0010001]; neuronal stem cell population maintenance [GO:0097150]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588] cadherin binding [GO:0045296]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] LVAVHELGHA;SEERRATDP 2 3 0.99252 -0.039695 0 0 0 0 10.6819 0 0 0 0 0 0 0 10.4177 0 0 A0A8I3S3N9 A0A8I3S3N9_CANLF LHFPL tetraspan subfamily member 1 LHFPL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RLGWAYYC;SYFLPYWLFGSQLGK;VTAVASSTSYFL 3 14.1 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.06851 0 0 0 A0A8I3S3P9 A0A8I3S3P9_CANLF Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) DDX5 Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; rhythmic process [GO:0048511]" cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA helicase activity [GO:0003724] LVEDRGSGRSRGRGGMKDDRRDR;NGYDSTQQYGSN 2 6.5 0.98995 -0.22329 0 7.8448 0 0 0 0 0 0 10.3178 0 0 12.7175 0 0 0 A0A8I3S3Q7 A0A8I3S3Q7_CANLF Prokineticin receptor 1 PROKR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EQIRKRLRCRRK;EVAAGLAEESAPN;IALVWLVSILIAIPAAYFTTET;RKTVLVLMCVLTAYVLCWAPFY 4 17 0.98633 -0.41167 0 7.29637 4.81619 0 0 0 0 12.4563 0 0 0 0 0 0 0 A0A8I3S3Q8 A0A8I3S3Q8_CANLF Outer dynein arm docking complex subunit 3 ODAD3 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; determination of heart left/right asymmetry [GO:0061371]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; multicellular organism growth [GO:0035264]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]; spermatogenesis [GO:0007283] axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; extracellular region [GO:0005576] FLAQGDTFRHLE;RMKAEEAEHITGVYLQ;SLRVKDKELKQRWTMYQ;TIVSQQKRQAE 4 9.4 0.91209 0.11051 0 9.65501 0 0 0 9.36807 0 0 12.5753 0 0 0 9.03543 0 0 A0A8I3S3R1 A0A8I3S3R1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRJ Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein tyrosine phosphatase activity [GO:0004725] ADSNCGFAEEYEDLKLV;KQQADSNCGFAEEYEDLK;LILTTGNAGHPSPDV;LPYDISRVKL;VSGLHLALLGFTQATLTWK 5 5.9 0.95152 0.049872 0 0 0 0 0 0 0 0 0 0 0 0 0 6.23347 0 A0A8I3S3R4 A0A8I3S3R4_CANLF Filensin (Beaded filament structural protein 1) BFSP1 Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; intermediate filament [GO:0005882]; plasma membrane [GO:0005886] structural constituent of eye lens [GO:0005212] GVSPSGSEGRGVRSS;KLARAPDRPAPT;LEEGREVVSLLQ;LTPEGAPEDVPDGGQ;PPGDGPKL;RGAGGGAG 6 7.8 1.002 -1.8354 0 0 0 0 0 0 0 0 0 9.63029 0 0 10.9299 0 0 A0A8I3S3R9 A0A8I3S3R9_CANLF Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) GPR153 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] endoplasmic reticulum membrane [GO:0005789] G protein-coupled receptor activity [GO:0004930]; protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671] ACFLGFVFGCGMLL;EDSDNDTSLESGIPP;FYTLTLATCF;IPPDLVLEHSLDY 4 8.1 0.99616 -0.085907 0 9.79536 0 0 0 9.37219 0 9.84002 0 0 0 0 0 0 9.34833 A0A8I3S3S3 A0A8I3S3S3_CANLF Heterogeneous nuclear ribonucleoprotein D like HNRNPDL Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; poly(A) binding [GO:0008143]; poly(G) binding [GO:0034046] AQRHVTAQ;KEYFGAFGEIENIELPMDTKTN;NSAAMEDMNEYSNIEEFAEG 3 13.8 0.97646 0.047323 0 0 0 0 0 0 5.81645 0 0 0 0 0 0 0 0 A0A8I3S3T1 A0A8I3S3T1_CANLF ETS homologous factor (ETS domain-containing transcription factor) EHF Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855] Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" HNPRGTHLWEFIRDIL;KKRKEKKRKRKKRKKN 2 8.2 0.95505 0.049233 0 0 0 6.80864 8.24679 0 0 0 0 0 6.73823 7.81346 0 0 0 A0A8I3S3T7 A0A8I3S3T7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338] COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737] AFLENWCILLSPRSTFRILYTDRYR;QRIWQRDFPG 2 17.3 0.97443 0.035538 0 0 0 0 0 0 0 0 0 0 0 8.01586 0 0 0 A0A8I3S3V1 A0A8I3S3V1_CANLF Proline rich and Gla domain 2 PRRG2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CRRGGGQQPCPQEAEL;DLELLTPGNLER;EDNTLTERFWE;PLGDLAPPTPLP 4 25.2 0.99121 -0.27005 0 0 12.6877 0 0 0 0 0 0 0 0 4.49927 0 0 0 A0A8I3S3V5 A0A8I3S3V5_CANLF Olfactory receptor OR51L1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YHYCHVNALSHAFCLHQD 1 5.7 0.97206 0.048313 0 9.60548 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S3W0 A0A8I3S3W0_CANLF dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) TMTC4 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] FRETGNKEG;QYTSKGRRLNLAPRSSLL 2 4 1.0029 -0.7559 0 0 0 8.70932 0 0 0 0 0 0 8.84191 0 0 0 0 A0A8I3S3W4 A0A8I3S3W4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] nucleus [GO:0005634]; proteasome core complex [GO:0005839] QVGFKNMQNMDHIL 1 6.5 0.94015 0.060962 0 0 0 0 0 9.11707 0 0 0 0 0 0 0 0 0 A0A8I3S3W7 A0A8I3S3W7_CANLF SSD domain-containing protein DISP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CQKLRNQTFFHQTDEQDFTSCF;EPRLSQDPEHW;ESMMDIYLDNF;GESMMDIYLDNFE;LSDGTLIAMGLSV;LSQDPEHWSPSGPKCVHSH;PLCPHPPWPGRRPHQP;TGDARCCPDTRHSCDQGTCGSEDP;VDWNFHKDSFFC;VGGAYVVCVNPKMKLPSLEL;YERMHQFYQEVDA 11 10.4 1.0026 -1.1828 9.71922 13.8009 0 8.84445 9.95651 0 0 9.88646 0 3.67796 0 0 0 3.58051 9.56818 A0A8I3S3Y6 A0A8I3S3Y6_CANLF Potassium channel tetramerization domain containing 16 KCTD16 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235] HCDCCCKN;VACNSSVTASFVNQYTDD 2 6.1 1.0017 -0.74307 0 0 0 0 0 0 0 0 0 0 0 0 0 11.022 11.3626 A0A8I3S3Y7 A0A8I3S3Y7_CANLF Deleted in malignant brain tumors 1 protein (Hensin) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; protein transport [GO:0015031] membrane [GO:0016020] AHFGPGSG;DGWQVASLSVGRFCAGTE;GGTGHIML;GVICAGERLSPHPSTGH;IMTVVFRSDAMI;IPYGRCGTVRQESLGSLG;VWMIQVAEKFHIE;WSDHNCGHHEDAGVICSGNQP;YNPLFSCPPGASLR 9 9.8 0.99956 -2.8794 10.7111 11.3944 9.99873 9.36648 11.2818 7.41015 9.41001 0 0 9.94584 11.6727 7.09908 0 9.77099 0 A0A8I3S417 A0A8I3S417_CANLF Coiled-coil glutamate rich protein 1 CCER1 Canis lupus familiaris (Dog) (Canis familiaris) CECDNEECDGKEEESQ;CECECDNEECDG;CECECDNEECDGKE;CECECDNEECDGKEEE;DCVEEGEEEQEEEEGE;DCVEEGEEEQEEEEGEEGEEDQ;EDCECECDN;EDCECECDNEECDG;EDCECECDNEECDGKE;EDQEEEEETEEEAVEEEEPREEENH;EEDQEEEEEEDQEEEEETEEEAVE;EEEEEEDQEEEEETEEEAVE;EEEGEEGEEDQEEEEEEDQ;EEGEEGEDCECECDNE;EEGEEGEDCECECDNEECD;EEGEEGEDCECECDNEECDG;EELERQQEALR;EEQGEEGEEGEDCECECD;EGEDCECECDNE;EGEDCECECDNEE;EGEDCECECDNEECD;EQGEEGEEGEDCECE;EQGEEGEEGEDCECECDNE;EQGEEGEEGEDCECECDNEE;GEDCECECDNE;GEDCECECDNEE;GEDCECECDNEEC;GEDCECECDNEECD;GEEGEDCECECDNEECDG;GEEGEDCECECDNEECDGKEEESQ;GEEGEEGEDCECECDNEE;QEEEEEEDQEEEEETEE;QEEQGEEGEEGEDCECECDNE;QEEQGEEGEEGEDCECECDNEECD;RRGAPIYKRRRRYGPKS 35 25 0.98633 -0.45428 9.59205 10.2599 8.17533 7.7301 10.9099 9.626 9.35125 6.82107 10.4386 7.27006 7.26725 5.7416 10.6431 8.59585 8.70619 A0A8I3S427 A0A8I3S427_CANLF E74 like ETS transcription factor 5 ELF5 Canis lupus familiaris (Dog) (Canis familiaris) sequence-specific DNA binding [GO:0043565] ACDSYWTSVHPEY;AGICGEYLYFILQNIRS;CGEYLYFILQNI;EAAGICGE;KRHVWEWLQFCCDQYKLDANCISFC;RSQGQCGGEGRASGGGPR;VHPEYWTKRHVWEWLQFCCDQYKLD 7 54.7 1.0026 -1.1634 0 0 10.6641 0 10.0454 0 0 0 0 8.94193 5.09997 0 0 9.14119 9.17428 A0A8I3S430 A0A8I3S430_CANLF Olfactory receptor family 52 subfamily X member 3 OR52X3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVRTKKIREHVLRVLK;VRTKKIREHVLRVLK 2 5.1 0.93947 0.10311 0 0 0 0 0 0 0 6.17732 0 0 0 0 0 0 0 A0A8I3S431 A0A8I3S431_CANLF Transporter SLC6A8 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] apical plasma membrane [GO:0016324] creatine:sodium symporter activity [GO:0005309] FLPQRWQHLTQPVWGLHHLEYRAQE;FMATEQGVHISKVAESGPGLAFI;PLVYNNTY;PYVVLVVLLVRGVLLP 4 9.8 0.9789 0.035538 9.79633 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S444 A0A8I3S444_CANLF "SEC22 homolog C, vesicle trafficking protein" SEC22C Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum membrane [GO:0005789] AAMAFCFLETVWWEFT;HISSIQMDSSLEKIQ;LNLIRGIHLAEHSLQ 3 15.2 0.99361 -0.1647 0 0 0 8.46871 0 0 0 0 0 0 0 0 10.5663 0 8.05772 A0A8I3S454 A0A8I3S454_CANLF Zinc finger protein 330 (Nucleolar autoantigen 36) ZNF330 Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, centromeric region [GO:0000775]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]" zinc ion binding [GO:0008270] DEAEDDEDED;EEEDEDEAEDDEDEDDEVGKDSDA;GVYSTGLA;YGDSSYHDEEEDEDEAEDDEDEDD;YHDEEEDEDEAEDDEDEDD 5 12.5 0.99077 -0.26592 0 0 0 0 0 0 0 0 0 10.1834 0 0 0 0 0 A0A8I3S462 A0A8I3S462_CANLF Disintegrin and metalloproteinase domain-containing protein 1a-like LOC119866150 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CDCGPDCG;FPVFSYHNGV;GVLDYNEECDCGPDCGNNLC;QEVPPPQE;VSEMGPEKEPQE;YNEECDCGPDCGN 6 5.5 1.0028 -0.97935 0 0 0 0 5.33303 0 0 0 0 0 0 11.7336 0 0 0 A0A8I3S463 A0A8I3S463_CANLF UPF1 RNA helicase and ATPase UPF1 Canis lupus familiaris (Dog) (Canis familiaris) "3'-UTR-mediated mRNA destabilization [GO:0061158]; cell cycle phase transition [GO:0044770]; DNA repair [GO:0006281]; histone mRNA catabolic process [GO:0071044]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA cis splicing, via spliceosome [GO:1905746]; regulation of telomere maintenance [GO:0032204]; regulation of translational termination [GO:0006449]; telomere maintenance via semi-conservative replication [GO:0032201]" "chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; supraspliceosomal complex [GO:0044530]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; double-stranded DNA helicase activity [GO:0036121]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; telomeric DNA binding [GO:0042162]; zinc ion binding [GO:0008270] EEDEEDTY;HVIKVPDNYGDEIAI;IRNMDSMPELQKLQ;LWKENPSATLED;PGGPGGGG;QLRARQITAQQINKLEELW;VLECYNCGCRNV;VLGIRPIRLQVQYRMHPAL 8 9.3 1.003 -1.5153 7.04418 0 8.8314 0 3.50157 0 0 12.0294 8.8254 0 0 0 8.95643 0 0 A0A8I3S466 A0A8I3S466_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase) MGRN1 Canis lupus familiaris (Dog) (Canis familiaris) endosome to lysosome transport [GO:0008333]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; protein ubiquitination [GO:0016567] early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] GVSDGLSQASCPL;STRQWALHFQA 2 4.6 0.98738 -0.2312 0 0 0 10.3854 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S470 A0A8I3S470_CANLF Regulator of microtubule dynamics protein 2 (Protein FAM82A1) RMDN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; microtubule [GO:0005874]; spindle pole [GO:0000922] GISLLLLWYHKVRKSRKT;LGSKFDSMTFQDEMYN;SNYLYLAKCYIDLEQA 3 12.7 0.93606 0.097546 0 0 0 0 4.74308 0 0 0 0 0 0 0 0 0 8.01859 A0A8I3S474 A0A8I3S474_CANLF "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.9)" ACADVL Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] VTDAATGA 1 1.3 1.0043 -1.1044 0 0 0 0 0 0 6.26228 0 0 0 0 0 0 0 0 A0A8I3S475 A0A8I3S475_CANLF "ERCC excision repair 6 like, spindle assembly checkpoint helicase" ERCC6L Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA translocase activity [GO:0015616]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] IIERLLKNRHFKILRVDGT;KDDETLPHCSPWPINPM;NGVIITTYQMLINN;PEVMLMTL;QELWSLFDFACQ;QELWSLFDFACQGSLL;SDVDHIDHVT 7 6.6 1.003 -0.8646 0 0 5.43162 0 0 6.69502 6.94357 0 10.1371 0 0 0 0 8.90391 0 A0A8I3S4A3 A0A8I3S4A3_CANLF Ribosomal protein L32 LOC106557771 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ALRPLVKPKIIKKRTK;ALRPLVKPKIIKKRTKK;DRYVKIKHNWWKRRGIDNRVHRRF;IIKKRTKKFI;VALRPLVKPKIIKKRTKKF;VALRPLVKPKIIKKRTKKFIWHQS 6 32.2 0.9898 -0.20049 0 0 0 5.2077 0 0 8.79097 0 0 0 0 0 0 0 5.31607 A0A8I3S4A7 A0A8I3S4A7_CANLF DUF4592 domain-containing protein KIAA1210 Canis lupus familiaris (Dog) (Canis familiaris) RGVEPPYKSLQKGAGLANENQP;RQAFAGPEYQPQ;RRGAKKGSSA;TRKRRAAARAA 4 2.7 0.98524 -0.44383 0 0 5.70741 0 0 0 9.28965 0 0 0 0 0 10.4691 0 0 A0A8I3S4A8 A0A8I3S4A8_CANLF Paraneoplastic antigen Ma-like C-terminal domain-containing protein ZCCHC18 Canis lupus familiaris (Dog) (Canis familiaris) ETWLIQVIGVLPVWNMSEEEKLEC;LDQILVIDSSNSSSTQ 2 10.8 0.98977 -0.21511 0 0 0 0 0 0 0 10.6692 0 0 0 0 0 0 0 A0A8I3S4C0 A0A8I3S4C0_CANLF Tetraspanin 9 TSPAN9 Canis lupus familiaris (Dog) (Canis familiaris) tetraspanin-enriched microdomain [GO:0097197] AGAFCGSA;CYEKVKMWFDDNKHVLGTVGMC;VLLIILLAELILLILFFV 3 14.5 1.003 -1.0092 0 0 0 7.15634 0 0 6.93676 0 3.87666 0 0 0 0 0 0 A0A8I3S4C1 A0A8I3S4C1_CANLF Uncharacterized protein LOC119868241 Canis lupus familiaris (Dog) (Canis familiaris) DQDQDQDQDQDQDQYQYQYQEN;KVLKPTLKAKRPLHRSLSKRIPEKS;QDQDQDQDQDQD 3 35.3 0.94384 0.082237 0 0 9.90388 0 0 0 0 4.13972 0 0 0 0 0 0 0 A0A8I3S4C4 A0A8I3S4C4_CANLF N-terminal EF-hand calcium binding protein 1 NECAB1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] NSFSPKSPQFS;TNYSKTFQRSNVDFL 2 7.8 0.98898 -0.19692 8.92205 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4C7 A0A8I3S4C7_CANLF Chromosome 8 open reading frame 58 C8orf58 Canis lupus familiaris (Dog) (Canis familiaris) GVAEDLALGCVVP;TGAKTAVA 2 5.7 1.0023 -1.3666 5.54804 0 0 0 0 0 7.39968 7.24031 10.4989 0 0 0 0 0 0 A0A8I3S4G1 A0A8I3S4G1_CANLF peptide chain release factor N(5)-glutamine methyltransferase (EC 2.1.1.297) HEMK1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-(glutamine-N5) methyltransferase activity [GO:0102559] NAQRLRLLDRIRIVPLDV;VGNWLQSQ 2 7.3 0.98788 -0.46109 0 0 0 0 0 0 0 0 6.637 0 0 0 0 0 0 A0A8I3S4G3 A0A8I3S4G3_CANLF Proline rich 5 like PRR5L Canis lupus familiaris (Dog) (Canis familiaris) FITDYFQNQLLAKG;LLAMATRMHPGLGEEPGGDD;TDYFQNQLLAKG;VINVFKGGGLQSNELYALNE;VLSDLPRFQAAR 5 17.9 0.86465 0.18569 0 0 0 0 0 11.6127 10.8099 0 0 0 0 0 0 0 0 A0A8I3S4G5 A0A8I3S4G5_CANLF Eomesodermin EOMES Canis lupus familiaris (Dog) (Canis familiaris) "brain development [GO:0007420]; CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302]; endodermal cell fate specification [GO:0001714]; mesoderm formation [GO:0001707]; positive regulation of transcription by RNA polymerase II [GO:0045944]" nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FLSFNINGLNPTAHYN;GAGGGGGG;SEEVANPPQRW;SLACETGSGEPTAASAGAPAAM;YPLESARGGGGGSAGHLPGAAP 5 11.2 1.0035 -1.0704 0 0 0 0 0 0 0 0 0 0 7.54751 0 0 0 0 A0A8I3S4G8 A0A8I3S4G8_CANLF Uncharacterized protein LOC100856515 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] EGAGIVESIG 1 2.8 0.99892 -0.61146 0 0 0 0 0 0 0 0 0 0 10.3952 0 0 0 0 A0A8I3S4G9 A0A8I3S4G9_CANLF Tyrosine-protein kinase (EC 2.7.10.2) HCK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] KLHAVVTE;PFGCGRPGSPGAAELGGRSSC;PGAAELGGRSSCEDPG;SGEWWKARSL 4 7.5 1.0017 -1.2492 0 0 10.0104 0 0 7.42593 0 0 8.96347 0 8.52568 0 0 0 0 A0A8I3S4H6 A0A8I3S4H6_CANLF Uncharacterized protein MBD3L1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] VTEEDIRKQDRKVK 1 7.2 0.93681 0.060945 0 0 5.30195 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4H9 A0A8I3S4H9_CANLF KLF transcription factor 13 KLF13 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell population proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" MLQRRSGSSRTGSLSD 1 5.5 0.96288 0.049233 0 0 0 0 0 0 0 0 0 8.00163 0 0 0 0 0 A0A8I3S4I2 A0A8I3S4I2_CANLF Chromosome 24 C20orf204 homolog C24H20orf204 Canis lupus familiaris (Dog) (Canis familiaris) AQKERGILLSI;TLRRVVAGRRRGALE 2 13.8 0.93762 0.089393 0 0 0 0 0 0 11.5411 0 0 0 0 0 5.29002 0 0 A0A8I3S4I5 A0A8I3S4I5_CANLF Ret finger protein like 4B RFPL4B Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CDHIFCFHCMQRWVLEH 1 6.3 0.97717 0.046227 0 0 5.92555 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4J6 A0A8I3S4J6_CANLF Histone H2B H2BC2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527] GFKRAVAKTQKKEGKKRRRCRKESY 1 19.7 0.97876 0.035538 0 0 4.3238 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4K1 A0A8I3S4K1_CANLF Vesicle transport protein SFT2D3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] AEPSGVAGPACWP;PALLLRARKFALL 2 12 0.91685 0.11923 0 0 0 0 0 0 0 0 0 9.16965 0 0 4.7454 0 0 A0A8I3S4K5 A0A8I3S4K5_CANLF DNA polymerase (EC 2.7.7.7) POLL Canis lupus familiaris (Dog) (Canis familiaris) "base-excision repair, gap-filling [GO:0006287]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]" nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861] 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] SFHKPVTSYQ;VLLTHPDGQSHQGIFSRL 2 4.9 0.99029 -0.51117 0 0 10.2252 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4K9 A0A8I3S4K9_CANLF Protein phosphatase 2 regulatory subunit B''beta PPP2R3B Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509] DLYEYACED;GVSHRAPCGAQAGAGA;HDLLIDSQDLARH;PVRADMRLR;TDHDLLIDSQDL;VLPSRFKKRLKAF;VSLLRDSESEGPELSD 7 10.9 1.0029 -1.7128 0 0 0 0 0 0 0 0 6.63183 9.77571 0 0 9.4283 5.68018 0 A0A8I3S4L1 A0A8I3S4L1_CANLF Anion exchange transporter (Solute carrier family 26 member 7) SLC26A7 Canis lupus familiaris (Dog) (Canis familiaris) gastric acid secretion [GO:0001696]; gluconate transmembrane transport [GO:0035429]; iodide transport [GO:0015705]; nitrate transmembrane transport [GO:0015706]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome [GO:0005768]; lateral plasma membrane [GO:0016328] chloride channel activity [GO:0005254]; chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; sulfate transmembrane transporter activity [GO:0015116] IPSFFFCIPSAAAMG;KRKIKVVLPV;QVACLISCI 3 5.2 1.004 -0.80727 0 0 0 9.70527 0 0 0 6.52224 0 0 0 0 0 9.25278 0 A0A8I3S4L3 A0A8I3S4L3_CANLF Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to nicotine [GO:0035095]; cognition [GO:0050890]; DNA repair [GO:0006281]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979] acetylcholine-gated channel complex [GO:0005892]; postsynaptic membrane [GO:0045211] acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848] DELAKPPP;LVSMHSRVDQ;MASAPGFWPEPE 3 4.8 0.99639 -0.58028 0 0 0 0 0 0 0 0 0 0 0 0 0 12.3952 0 A0A8I3S4L4 A0A8I3S4L4_CANLF "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-methylbutyryl-coenzyme A dehydrogenase)" ACADSB Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631]; isoleucine catabolic process [GO:0006550] mitochondrion [GO:0005739] 2-methylbutanoyl-CoA dehydrogenase activity [GO:0003853]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802] SPTLFPPRCLLQVSREQ;VINNLMRKYG 2 5.3 0.99427 -0.18949 0 0 0 0 0 0 13.9555 0 0 0 0 0 0 0 0 A0A8I3S4M9 A0A8I3S4M9_CANLF Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) CPTP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226] cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886] ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388] FIEHVYNISQ;MLGEALPFIEHV;SLAAYHPWI;VLLDHYLAG 4 16.4 1.004 -1.9861 11.6309 0 0 0 0 8.52521 0 0 0 0 4.88899 0 0 0 0 A0A8I3S4P4 A0A8I3S4P4_CANLF Olfactory receptor LOC119864890 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FFHHCSFV;GVARLACA;VPRTFHILFA 3 8.3 1.0029 -1.122 0 0 0 0 0 0 0 11.2082 0 0 0 0 0 0 0 A0A8I3S4P5 A0A8I3S4P5_CANLF ATP binding cassette subfamily A member 12 ABCA12 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDALDDLVS;EQNSTSEDIRRKLC;ERLGGFDLLLKKIMAILIKR;GTYGMAAPWYFPVLPSYWKE;LEEVFINFAKD;LFKGSGIQ;LLVTIIILIIILK;LQNTLRNPFVQVFVKF;LSSLTVNISSCVLY;LVSVEEHLYFYARIHGI;LVTIIILIIILK;LVTIIILIIILKFGNILPKTNGFI;QGTMFFFLRLLINEWLIKKLRLFFR;QMNYLENITQLMP;QWENMYSSPVQDD;SIDLIDHLN;SRQSYLIGLTLL;TSEDIRRKLCESY;VEELKEELRRTTGM 19 9.2 0.97197 0.048206 0 0 0 4.38585 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4P7 A0A8I3S4P7_CANLF Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (Skin fibroblast elastase) MME Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222] LWEGCTWK;TYGTSWTAE 2 4.2 1.0036 -1.063 4.74835 0 0 9.37034 0 8.42076 0 0 5.03606 0 0 0 0 5.02985 6.1418 A0A8I3S4P9 A0A8I3S4P9_CANLF G protein pathway suppressor 2 GPS2 Canis lupus familiaris (Dog) (Canis familiaris) B cell differentiation [GO:0030183]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of JNK cascade [GO:0046329]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]; response to mitochondrial depolarisation [GO:0098780] cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053] cyclin binding [GO:0030332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714] LMAADRAKQM 1 3.1 0.99229 -0.16742 0 0 11.2426 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4T1 A0A8I3S4T1_CANLF CCR4-NOT transcription complex subunit 10 CNOT10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634] AAICLRNALLL;AEQETKGLPSKKGI;FAMSKHNLGIFYFK;ISLDRISDA;LHQVNPVAGP 5 8.1 0.9881 -0.49449 11.2016 0 0 9.28988 0 6.00713 10.084 0 0 0 8.38478 0 0 0 0 A0A8I3S4T3 A0A8I3S4T3_CANLF Solute carrier family 17 member 1 SLC17A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] CLVFGKADIQDWAKGNQ;ILRLITIRKLFNTLGLLLPAFF;SSIYSMTI;VLCLLFCLVFGK 4 12.8 0.99632 -0.58141 0 0 0 12.9964 0 10.3349 0 6.70805 0 0 0 0 0 0 0 A0A8I3S4U5 A0A8I3S4U5_CANLF Dynein cytoplasmic 1 intermediate chain 1 DYNC1I1 Canis lupus familiaris (Dog) (Canis familiaris) transport along microtubule [GO:0010970] cytoplasmic dynein complex [GO:0005868] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] QDQKQEVKEAPP;QSSVMSVCFARFHPNLVVGG;WNLNNDTEVPT;WTRFARTLVEIRANR 4 9.3 0.98657 -0.42785 0 0 0 0 0 0 9.84254 0 7.34944 0 0 0 0 0 0 A0A8I3S4V8 A0A8I3S4V8_CANLF Transmembrane protein 178A TMEM178A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of osteoclast differentiation [GO:0045671]; regulation of cytosolic calcium ion concentration [GO:0051480] endoplasmic reticulum membrane [GO:0005789] TAIFTDHWYETDPRRHK 1 5.7 0.98438 0.046227 0 0 9.19943 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4W0 A0A8I3S4W0_CANLF Calsyntenin-3 CLSTN3 Canis lupus familiaris (Dog) (Canis familiaris) "homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558]; regulation of presynapse assembly [GO:1905606]; synapse assembly [GO:0007416]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]" cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]; neurexin family protein binding [GO:0042043] EDSSDSEAA;ELQTSHVAKGCDRDNYSERAL;EVEGYVVVLQPD;GAATGEVDLL;GTAHFARPAV;LQVPHLSRPAN;PLFALDKDA 7 7.8 1.0031 -1.9457 8.94895 6.70694 10.7354 13.2317 0 0 0 10.4292 0 0 8.52662 12.2334 0 0 7.77952 A0A8I3S4W3 A0A8I3S4W3_CANLF Glutathione transferase Canis lupus familiaris (Dog) (Canis familiaris) SPKVQDAAHGTLLAAG 1 6.8 0.98723 -0.23065 0 0 0 13.0699 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S4W9 A0A8I3S4W9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; small-subunit processome [GO:0032040] RRIRKIPG 1 4 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 4.71436 0 0 0 0 A0A8I3S4X4 A0A8I3S4X4_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP3CA Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-NFAT signaling cascade [GO:0033173] calcineurin complex [GO:0005955]; cytosol [GO:0005829] calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872] DSNGSNSS;GCSYFYSYPA;TEYFTFKQECKIKY 3 6.8 1.0024 -1.3589 0 8.65417 0 0 0 5.7423 0 0 0 0 0 6.25697 0 0 0 A0A8I3S4Y2 A0A8I3S4Y2_CANLF Coiled-coil domain-containing protein CCDC50 Canis lupus familiaris (Dog) (Canis familiaris) AQVLIVVVITPILVCRDFAVL;DQPQSRRARELGSGV;GGSARPQPPGVPRHK;PLPGSEIGYRS;RPDFAPRRALLLLLGL 5 7.7 0.98982 -0.22338 0 0 0 8.30022 0 0 0 0 0 0 0 0 0 9.57353 8.86205 A0A8I3S4Z4 A0A8I3S4Z4_CANLF TNF alpha induced protein 8 like 3 TNFAIP8L3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] cytosol [GO:0005829]; nucleoplasm [GO:0005654] VIVEKLRKKLN 1 5.4 0.9813 0.035491 0 0 0 0 0 4.67548 0 0 0 0 0 0 0 0 0 A0A8I3S503 A0A8I3S503_CANLF Solute carrier family 25 member 13 SLC25A13 Canis lupus familiaris (Dog) (Canis familiaris) malate-aspartate shuttle [GO:0043490] mitochondrial inner membrane [GO:0005743] calcium ion binding [GO:0005509] SPNDFVTRYL;VLRYEGFFGLYRG 2 3.4 0.9922 -0.54069 10.4391 0 0 0 0 0 11.9007 0 0 0 0 0 9.96939 0 0 A0A8I3S513 A0A8I3S513_CANLF Elongation factor for RNA polymerase II ELL Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] transcription elongation factor complex [GO:0008023] SLPLLTDCAQPS;VSDGSKVSVFHVKLTD 2 4.6 0.98833 -0.47398 0 0 0 0 0 0 0 0 9.56115 0 0 0 0 0 0 A0A8I3S518 A0A8I3S518_CANLF Chromosome 4 open reading frame 54 C4orf54 Canis lupus familiaris (Dog) (Canis familiaris) APAPVPAD;GGGGGGGA;GGGGGGGG;LKCGGVGA;NSDCENYL;RVEQSLLR;SPEHLPTAIYHQQPL;VTTGQYYLVDT;YHQQPLPF 9 4.4 0.99947 -2.9159 0 9.22954 0 0 12.959 12.3385 0 0 0 0 0 0 0 8.55731 0 A0A8I3S519 A0A8I3S519_CANLF LLGL scribble cell polarity complex component 1 LLGL1 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] ACEDYAETCLAC;APQSRNGSPDPGH;EEQFKVFTLPKV;IFSGGMPRASY;LSFQPPSRPGFDSASG;MQGGHAVLIASEEQF;VEHGFPNQPSALA;VGCFDPYSDD;VTLHAEWSLVAFGTSHG 9 11.1 1.003 -0.78182 0 6.67455 0 8.41105 8.32701 8.32021 0 9.23436 10.6799 0 0 0 8.4718 0 0 A0A8I3S533 A0A8I3S533_CANLF Nucleoporin NUP188 NUP188 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606] nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] LLDQSLDLAEY;LLQRLTTVISPPV;PVLLAWALLRHTL;QQFEELYKTEAPTWETH;SSSKQPTADTE;YYKPPSPNSAEKV 6 4.5 1.003 -0.73098 3.49927 0 0 0 0 0 0 6.90797 4.86438 0 0 0 0 5.74306 0 A0A8I3S535 A0A8I3S535_CANLF glucuronosyltransferase (EC 2.4.1.17) UGT1A6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] UDP-glycosyltransferase activity [GO:0008194] GVPMVMLPLFGDQMDNAKR;LSESFLCNVVYSPYEPL;PVPFRRED;YLALPAVF 4 9.3 0.98767 -0.48103 0 0 0 0 0 0 0 9.32078 0 0 0 0 6.5523 10.656 0 A0A8I3S538 A0A8I3S538_CANLF C2 domain-containing protein FER1L4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] DIPDPEELDWWSKYYA;DVDGYNAWRDAFRPSQILAG;EAEFELLTVE;ISRGVPQNRPIKLLV;LRLQLRDDAPLVDV;QGQKTPDPFLA;QHEEREQREAQA;QPLLETDTGDGPGDEEE;RILVLLLLLALVAVFLLLVLY;RPIKLLVRVYV;RQVMLNFRGFTQ;RYWRILVLLLLLALVAVFLLLVLYT;SRGVPQNRPIKLL;VGMPRRLLKAPLKKLPLG;VLLLLLALVAVFLLLVLYTMP;VRVYVVKAT;VWDYDRISANDF;YHPRSPGL;YPESEAVSFSEPK 19 11.3 0.99913 -3.2149 10.4042 5.74886 8.0782 7.00787 5.67132 12.906 9.8396 0 9.15818 11.1826 9.30074 10.7908 5.60552 4.79161 11.6681 A0A8I3S540 A0A8I3S540_CANLF Tau tubulin kinase 2 TTBK2 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; signal transduction [GO:0007165] ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] IHSVGFLH;LRKIGGGG;NSIKTFGVIESD;TDKFLETWYKI;VGILVKERWKVLRKIG 5 11.3 0.9904 -0.20201 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.59669 A0A8I3S545 A0A8I3S545_CANLF SSD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FIMISAWQKTNAKDSVTAI;KENGTQIGYNGV;LYVAKENG;VGNFCYCFCDCGSNRFH 4 11.5 0.98472 -0.24491 0 0 0 0 0 0 0 0 12.7542 0 0 0 0 0 0 A0A8I3S549 A0A8I3S549_CANLF Uncharacterized protein LOC111098084 Canis lupus familiaris (Dog) (Canis familiaris) LEAEEEIYWGCFYFFPWLRMWRR 1 26.4 0.97942 0.046253 0 0 0 0 6.49536 0 0 0 0 0 0 0 0 0 0 A0A8I3S563 A0A8I3S563_CANLF Kinesin-like protein KIFC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] PQRSPLLE;SLRFASKVNQCVI;VPAQKPGAAAP 3 4.8 1.0026 -0.75765 0 8.93186 0 0 9.58015 0 9.77818 0 0 0 0 0 10.5449 15.1463 0 A0A8I3S566 A0A8I3S566_CANLF dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) DLD Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252] dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660] LRTYADQP;MAHGKDFASRGIENL 2 20.2 0.9874 -0.22885 0 9.76908 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S567 A0A8I3S567_CANLF Trichoplein keratin filament-binding protein TCHP Canis lupus familiaris (Dog) (Canis familiaris) axoneme [GO:0005930] EALRLSMDLREG;QEEQELLARELEAL;QQWDQNSRYF 3 6.4 0.98883 -0.204 0 0 7.5397 0 0 0 0 0 0 0 0 0 8.81314 0 0 A0A8I3S577 A0A8I3S577_CANLF Uncharacterized protein COL5A2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020] GPDGPKGSPGPSGTPGDTGPP;GPIGARGPEGPPGKPGED;GPLGPIGPPGVRG;GSDGLPGPK;GSDGLPGPKGAQ;GVPGLKGGRGTQGPPGATGFPG;PGSAGRVGPPGPPGAPG;PLPEFTEDQ;PTGPMGDP;SQIETMRS;TPGDTGPP;VGATGSKG 12 12.1 0.99681 -4.5159 8.94939 0 0 10.3905 0 0 9.65467 7.2738 0 8.15517 0 0 5.41785 13.7429 9.73207 A0A8I3S578 A0A8I3S578_CANLF B cell scaffold protein with ankyrin repeats 1 BANK1 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; MAPK cascade [GO:0000165]; negative regulation of B cell activation [GO:0050869]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of translational initiation [GO:0045947]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; response to bacterium [GO:0009617] perinuclear region of cytoplasm [GO:0048471] phospholipase binding [GO:0043274]; protease binding [GO:0002020]; protein tyrosine kinase binding [GO:1990782]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102] AEGAEADELAEENQ;EASLHLDCLL;PKEEEKKEDER;VHHPNGNE 4 5.5 1.0031 -1.9296 0 0 0 12.2789 0 8.77396 8.853 0 0 7.88393 0 0 0 0 0 A0A8I3S581 A0A8I3S581_CANLF Replication factor C subunit 4 RFC4 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] KESKTTRFCLICNYVSRI 1 5.4 0.98363 -0.25658 0 0 0 0 0 0 0 0 0 0 0 8.85839 0 0 0 A0A8I3S585 A0A8I3S585_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314] Arp2/3 protein complex [GO:0005885]; nucleus [GO:0005634] LVAAGHDCFPAL 1 8.1 0.99331 -0.165 0 0 0 0 0 0 12.1995 0 0 0 0 0 0 0 0 A0A8I3S586 A0A8I3S586_CANLF Coiled-coil domain containing 174 CCDC174 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DLLEMDKNLQGRLF;ENEARQLGVGYF;EQTTDQRTKRENIKE;GVPHVREWDRGKDFSFGFWSKR;IDEEVEDMYL;LEEKAKLYEKM 6 18.1 0.98741 -0.32634 0 0 5.58123 4.15421 3.12487 0 0 11.4298 0 0 0 8.8071 0 0 0 A0A8I3S589 A0A8I3S589_CANLF Chromosome 10 C2orf92 homolog C10H2orf92 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLFWTQDEI;VVTTLLLLALTTCIRRKRPLHP 2 11.9 0.99279 -0.17781 0 0 6.36207 8.59943 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S598 A0A8I3S598_CANLF Phytanoyl-CoA dioxygenase domain-containing protein 1 PHYHD1 Canis lupus familiaris (Dog) (Canis familiaris) 2-oxoglutarate-dependent dioxygenase activity [GO:0016706] GEVVHKSE;HGEVVHKSEQNLS 2 4.8 1.0018 -1.42 0 0 0 0 0 0 0 0 0 0 7.2182 0 0 0 0 A0A8I3S599 A0A8I3S599_CANLF Low-density lipoprotein receptor LDLR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869] clathrin-coated pit [GO:0005905]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362] calcium ion binding [GO:0005509] CDGGPDCK;DGQMDCENGSDEQ;DGQMDCENGSDEQGC;FLCKPGAG;HGSRQCDKEYDCKDMSDEI;IQWPNGIT;LYIILPIVLLILL;MDCENGSDEQGCPPKTC;SLVTEDIQWPN;VGALYIILPIVLLIL 10 10.5 0.98987 -0.26592 0 0 0 0 8.12138 0 0 0 0 0 0 0 0 0 0 A0A8I3S5A4 A0A8I3S5A4_CANLF Coiled-coil domain containing 174 CCDC174 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AEQKIEEQKTLDKARWHSSIKRN 1 19.2 0.97595 0.04644 0 0 0 0 0 0 0 7.36772 0 0 0 0 0 0 0 A0A8I3S5A5 A0A8I3S5A5_CANLF Collectin-11 COLEC11 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] carbohydrate binding [GO:0030246] GVRETDSKIY 1 4.1 1.0001 -0.61146 0 0 0 0 0 0 7.94122 0 0 0 0 0 0 0 0 A0A8I3S5A8 A0A8I3S5A8_CANLF Nyctalopin NYX Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] LFRNPWRCDCRLEWLRDWMESS;SLRRLSLRHN 2 6.8 0.98948 -0.52107 0 0 0 0 0 0 0 11.3944 0 0 0 0 10.0421 0 0 A0A8I3S5A9 A0A8I3S5A9_CANLF "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" LSHAETRATVKG 1 4.3 0.99092 -0.22198 0 0 0 0 0 0 0 0 0 0 0 0 12.3787 0 0 A0A8I3S5B8 A0A8I3S5B8_CANLF Serine/threonine/tyrosine kinase 1 STYK1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EQQYEIIIIPTILV 1 3.3 0.94175 0.061052 0 0 8.19618 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5C7 A0A8I3S5C7_CANLF "beta-galactoside alpha-(2,6)-sialyltransferase (EC 2.4.3.1)" ST6GAL1 Canis lupus familiaris (Dog) (Canis familiaris) N-acetylneuraminate metabolic process [GO:0006054]; protein N-linked glycosylation via asparagine [GO:0018279]; sialylation [GO:0097503] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] "beta-galactoside alpha-2,6-sialyltransferase activity [GO:0003835]; protein homodimerization activity [GO:0042803]" EKQAATLSSTQNPPRA;RLQKIWRNYL 2 6.5 0.99296 -0.27173 0 0 0 9.82936 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5C9 A0A8I3S5C9_CANLF Nuclear RNA export factor Tap RNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] NLSKNESVWELC;VGTAWGQT 2 5 1.0041 -1.0539 6.31296 0 10.4565 0 0 5.69237 0 0 0 10.0377 0 0 0 9.86333 0 A0A8I3S5D0 A0A8I3S5D0_CANLF Gamma-aminobutyric acid type A receptor subunit epsilon GABRE Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of chloride transport [GO:2001226] chloride channel complex [GO:0034707]; GABA-A receptor complex [GO:1902711]; postsynaptic membrane [GO:0045211] GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851] AFVCQIEDSEESDEEEGPSC;EAFVCQIEDSEESDEEE;ESEMIYKWENFKLQ;SIMDMEYT;TIDITFCQTWYDERLR 5 11.9 1.0037 -1.1043 9.39373 5.14686 0 0 0 0 0 10.2336 10.3436 0 6.51373 6.38026 0 0 9.94847 A0A8I3S5E6 A0A8I3S5E6_CANLF Ligand of numb-protein X 2 LNX2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CFECGQQH;EVQIVEEAT;EVQIVEEATQATEE;TCQEKHITVKKEP 4 5.5 1.0022 -0.76971 10.5354 9.38059 0 0 0 12.5759 9.54179 0 0 0 0 0 0 0 0 A0A8I3S5G5 A0A8I3S5G5_CANLF EEF1A lysine methyltransferase 2 (EC 2.1.1.-) (Methyltransferase-like protein 10) (Protein-lysine N-methyltransferase METTL10) EEF1AKMT2 METTL10 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytosol [GO:0005829]; nucleoplasm [GO:0005654] protein-lysine N-methyltransferase activity [GO:0016279] GGCSGGGGG;SGGGGGGA;SLWRPQRPSGAP 3 6.5 0.98504 -0.24608 0 10.2904 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5I3 A0A8I3S5I3_CANLF WASP actin nucleation promoting factor WAS Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886] actin binding [GO:0003779]; small GTPase binding [GO:0031267] GDEDDDDEWDD;SSRYRGLPALGPGP 2 5.3 0.98117 0.035491 0 0 0 2.85902 3.44055 0 0 0 0 0 0 0 0 2.81678 0 A0A8I3S5I8 A0A8I3S5I8_CANLF Fas apoptotic inhibitory molecule FAIM Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of neurogenesis [GO:0050769] CFFLSWLLI;RMETAGEFVEDGTETHFS;WDVALSDGVHKIE 3 16.5 0.98494 -0.44732 0 0 0 5.60039 6.13235 8.48022 0 0 0 0 8.00208 8.62062 0 7.96168 7.8166 A0A8I3S5J3 A0A8I3S5J3_CANLF small monomeric GTPase (EC 3.6.5.2) RASL11A Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase I [GO:0045943] nucleolus [GO:0005730] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DSLSKCVQWAE;FLLVYSITDYDSYQSI;VQDNLTQVVDSLSKCVQ 3 14.9 0.9905 -0.13794 7.82604 0 9.44 8.59167 0 0 0 0 0 0 0 0 0 0 9.90739 A0A8I3S5J6 A0A8I3S5J6_CANLF Protein LDOC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LTGPALQWVIPYIRKGSP 1 16.7 0.98785 -0.2277 0 0 0 0 0 8.99127 0 0 0 0 0 0 0 0 0 A0A8I3S5J7 A0A8I3S5J7_CANLF Uncharacterized protein PHTF1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] LWDDLLHGP;QITRPSGNNGNRRRRIKKVKLI;VNTLHSGTKRDPKED 3 6.4 0.97247 0.046699 0 0 0 0 0 0 0 9.14606 0 0 0 0 0 0 0 A0A8I3S5J8 A0A8I3S5J8_CANLF FHA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VIRFGYDILSWQWWGPQWAQQGPA 1 16.9 0.97413 0.041303 0 0 0 0 0 0 0 0 9.52129 0 0 0 0 0 0 A0A8I3S5K0 A0A8I3S5K0_CANLF MBL associated serine protease 1 MASP1 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, lectin pathway [GO:0001867]; proteolysis [GO:0006508]" extracellular space [GO:0005615] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] ADCGAPAE;CDHYCHNYIGGYYCSCRFG;ESPVLNDFVMPI;LRPSDFKVIMG;MPANSRDTQ;TFCGRETTDTEQ;VETEEQVLAT;VYTQRTGVITSP 8 13.8 1.003 -2.5465 11.7557 12.5693 0 0 6.68958 0 0 11.0994 9.62547 0 0 9.43858 0 12.7922 0 A0A8I3S5K1 A0A8I3S5K1_CANLF Pleckstrin homology domain containing A7 PLEKHA7 Canis lupus familiaris (Dog) (Canis familiaris) AGGPRWGSGVCGFGAHLLPGVCP;DYDLDISRELSKPE;ERREQEEERYR;FILQEEPHPHMSKQ;RMKRHQKALVRERKRTLSQGERTGL;WNEYLKLES 6 6.6 1.0037 -1.0662 0 0 0 0 0 0 8.5841 0 0 0 0 0 11.0107 5.02658 0 A0A8I3S5K2 A0A8I3S5K2_CANLF Delta-like protein DLL1 Canis lupus familiaris (Dog) (Canis familiaris) establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; Notch signaling pathway [GO:0007219] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] calcium ion binding [GO:0005509] DCASSPCANGGTCRDGV;GKPKVAAA;GVDSFSLP;GVNEYSCTCPPGYTG;GVTLNTGTPPRPVLC;HYYGEGCSVFCRPRDDAFG;SRYCDQCI 7 9.7 1.003 -2.1549 0 8.71716 0 0 0 0 0 9.62998 0 0 0 0 0 0 10.9656 A0A8I3S5K9 A0A8I3S5K9_CANLF EFR3 homolog B EFR3B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659] actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; plasma membrane [GO:0005886] LVDNIFPEDPED;QVVEKFQKAPFEEIAAHCG;SFVKFANIEE;SRFSEMCHSSHDDME;VKTNMEKLTFY;WASHRWDFCMMHVPFIIKSLGNHS 6 11.6 0.97367 0.041303 0 0 0 6.09436 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5L9 A0A8I3S5L9_CANLF Leucine rich repeat LGI family member 3 LGI3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ACSVLKWDYVERQLRD 1 3.1 0.96298 0.049233 0 0 0 0 0 0 0 9.30882 0 0 0 0 0 0 0 A0A8I3S5M1 A0A8I3S5M1_CANLF Acetylcholine receptor subunit gamma CHRNG Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] GVRKVFLRLLPQLLRMHVR;LLAVTILIVVNAVVV;WQNCSLVFQSQTYSTN 3 9.6 0.85843 0.15252 0 8.15512 0 0 10.4565 0 0 0 0 0 0 0 4.29322 5.60582 0 A0A8I3S5N3 A0A8I3S5N3_CANLF Glucocorticoid modulatory element binding protein 2 GMEB2 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; nucleoplasm [GO:0005654] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sequence-specific double-stranded DNA binding [GO:1990837] AEYIPLTPATAD;LVKKVLASHKCQMDRSREQ;MATPDVSVHMEEVGGG;MDSGELDFYQ 4 10.6 0.98792 -0.3763 0 0 0 7.9318 0 0 0 0 0 0 10.6356 0 6.18168 0 0 A0A8I3S5N9 A0A8I3S5N9_CANLF MARCKS-related protein (MARCKS-like protein 1) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calmodulin binding [GO:0005516] GGGDSSASSPTEEEQ;IGDAIEPA 2 12.4 0.98982 -0.51671 0 10.2467 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5P4 A0A8I3S5P4_CANLF Chromobox 6 CBX6 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] heterochromatin [GO:0000792]; nuclear body [GO:0016604]; PcG protein complex [GO:0031519] single-stranded RNA binding [GO:0003727] KLLPETMSPSAPDWR;SIIKRRIRKVSPLPRRDA;TVGGGSGG;TVRIINRKVKPREPKRNRI 4 12.6 0.9958 -0.11429 0 0 0 0 0 0 0 8.33459 9.77106 0 0 3.58749 5.56166 0 0 A0A8I3S5P6 A0A8I3S5P6_CANLF Olfactory receptor OR9G4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLMLYLMTLSGNMTL;KVAALFYTVVNPLLN;LMLYLMTLSGNMTL;VGNRTILT 4 12.2 0.9863 -0.45114 0 0 0 0 0 9.34174 0 0 0 7.9629 0 0 0 9.97656 0 A0A8I3S5P8 A0A8I3S5P8_CANLF G protein-coupled receptor associated sorting protein 2 GPRASP2 Canis lupus familiaris (Dog) (Canis familiaris) hematopoietic stem cell homeostasis [GO:0061484] cytoplasm [GO:0005737]; nucleus [GO:0005634] amyloid-beta binding [GO:0001540]; G protein-coupled receptor binding [GO:0001664] DFFESESEDEYYKESWFLPGE;EETSNESGFWSADETS;QAWAQTEFGAE;RPKNESQAMAGA 4 7 0.9861 -0.45481 0 0 0 0 0 0 0 0 3.79369 0 9.03557 0 0 0 0 A0A8I3S5Q2 A0A8I3S5Q2_CANLF Zinc finger protein 800 ZNF800 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] KHILLKDVDTIFECKLCRSLF;KKFYCPPSLQ;PSDEQPQESQAD 3 6.5 0.99524 -0.56378 0 0 0 0 0 0 0 0 0 0 0 6.75556 0 0 9.70266 A0A8I3S5Q3 A0A8I3S5Q3_CANLF Keratin 85 KRT85 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EFVVLKKD;ITVMAPDSCA;VGSVNVCV 3 5.1 0.9995 -0.61146 0 0 4.37407 0 0 0 0 0 9.28432 4.1929 0 0 0 5.40371 3.77484 A0A8I3S5R2 A0A8I3S5R2_CANLF LysM and putative peptidoglycan-binding domain-containing protein 2 LYSMD2 Canis lupus familiaris (Dog) (Canis familiaris) AERPAAAPVRRKRRRRRRR;EKPLSFNGLNSIDSP;PAAAPVRRKRRRRRRRR;PAERPAAAPVRRKRRRRRRRRTRRR;RKRRRRRRRRTRRRPL;TAAGEDLSPPSPQESD 6 14 0.94503 0.084771 0 0 0 0 0 6.48014 0 6.44231 0 0 0 0 7.01078 0 0 A0A8I3S5R3 A0A8I3S5R3_CANLF C-type lectin domain-containing protein LOC119866326 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ITIVLIPFFS;TYVCKHQI 2 7.6 0.99116 -0.27542 0 0 0 0 0 0 0 0 0 10.9632 0 0 0 0 0 A0A8I3S5R7 A0A8I3S5R7_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) ACVR1C Canis lupus familiaris (Dog) (Canis familiaris) cellular response to growth factor stimulus [GO:0071363]; nervous system development [GO:0007399] activin receptor complex [GO:0048179] "activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]" CHSSNNVTKTECCFTDFC 1 5.4 0.97259 0.048313 0 0 0 0 0 0 0 5.09411 0 0 0 0 0 0 0 A0A8I3S5S1 A0A8I3S5S1_CANLF IGFBP N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCCCSAPG;GCCCCSAP;GCCCCSAPGVEASMC;SGGGSGCCC;SGGGSGCCCF;VGFLGCCCCS 6 25 0.99779 -3.3436 11.241 11.2776 10.8007 10.2445 10.4333 9.53609 10.8859 9.73549 10.3471 10.8221 10.3898 11.0481 10.8599 10.3971 11.0875 A0A8I3S5S2 A0A8I3S5S2_CANLF Rho guanine nucleotide exchange factor 33 ARHGEF33 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] LIQKRKKLKK;LPECISLVHV;NFLDYYVAYL;NNFLDYYVAY;QHGEYALEEKVKSCRCSMEEKVTEM;QIYQLQALASELKTGFTEAMQELSR;TNDENNFLDYYVAYLRDLP;TQKEEHGSQAGP 8 11.7 1.0015 -1.8079 9.37654 0 19.494 8.26557 0 0 11.0553 15.4599 13.311 4.74782 10.9268 0 20.2588 0 10.4325 A0A8I3S5S4 A0A8I3S5S4_CANLF Pleckstrin homology domain containing M3 PLEKHM3 Canis lupus familiaris (Dog) (Canis familiaris) myoblast differentiation [GO:0045445] Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] LFAPSPVL;LSYNVDVCLAVQMDNLDDCD;MFELSYQN 3 4.8 1.0026 -1.8982 0 0 0 0 0 0 0 7.1334 0 0 0 0 0 0 0 A0A8I3S5T2 A0A8I3S5T2_CANLF Uncharacterized protein ZNF70 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DEYEGNFSL;KTHTGKRPY 2 4 1.0036 -1.0635 0 0 0 0 0 0 0 0 0 0 0 0 4.23665 7.36973 10.0121 A0A8I3S5U0 A0A8I3S5U0_CANLF Protein YIPF YIPF2 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] Golgi membrane [GO:0000139] small GTPase binding [GO:0031267] GVRERMGPYTFLETV;LETVCIYGYSLF 2 8.5 0.99236 -0.19317 7.72479 0 0 0 0 0 9.3187 0 0 0 0 0 0 0 0 A0A8I3S5U6 A0A8I3S5U6_CANLF Ectonucleoside triphosphate diphosphohydrolase 8 (EC 3.6.1.5) ENTPD8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] VGALDMGG 1 1.7 0.98979 -0.26592 0 0 0 8.92964 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5V4 A0A8I3S5V4_CANLF protein-ribulosamine 3-kinase (EC 2.7.1.172) FN3K Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389] protein-fructosamine 3-kinase activity [GO:0102194] CREEESTLGRRAEG;GAGGGGGG 2 5.6 0.99423 -0.15478 0 0 9.8412 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S5V9 A0A8I3S5V9_CANLF Ig-like domain-containing protein LOC119868981 Canis lupus familiaris (Dog) (Canis familiaris) IGHPDMSYVSGSG;VGTYYCVKLT 2 8.9 0.99272 -0.067672 0 0 0 0 9.75447 0 0 0 0 0 0 0 0 0 9.36669 A0A8I3S5W1 A0A8I3S5W1_CANLF Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] mitochondrial outer membrane [GO:0005741] FVKKKKKKKKKKNIY;KKKKKKKK;KKKKKKKKKKN;KKKKKKKKKKNIYIYIY;KKKKKKKKKNIYIYIYIYIYIYIYI;KKKKKKKN;VKKKKKKKKK;VKKKKKKKKKKNI;VKKKKKKKKKKNIYI;VKKKKKKKKKKNIYIYIYI;VKKKKKKKKKKNIYIYIYIYIYIYI 11 12.8 0.64017 0.33402 5.47362 0 0 6.3871 4.82949 0 5.85766 5.13537 0 0 0 0 6.92967 0 4.82339 A0A8I3S5W6 A0A8I3S5W6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HIRMDKYCFVS;KDGTFNWMSWLLVNL;VSPPDVAGEVELQ 3 11.1 0.98538 -0.25906 0 0 0 0 0 8.39034 0 0 0 0 0 0 0 0 0 A0A8I3S5W7 A0A8I3S5W7_CANLF LLGL scribble cell polarity complex component 2 LLGL2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; L-leucine transport [GO:0015820]; regulation of establishment or maintenance of cell polarity [GO:0032878] cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231] PDZ domain binding [GO:0030165] DEEAEHAVE;EEQFKVFTLPKV;EQFKVFTLPKVSAKLKLKL;GGSTLSTMRRFLRPGHDPA;GYRWKGHERL;NQQLENVCWQ;PRCLVESAEA;VGSFDPYSDDPRL 8 8.3 0.98321 -0.25556 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5032 A0A8I3S5Y0 A0A8I3S5Y0_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] IEMILTEKEQIVPKPEEEVAQK;VAQKKKIPQKKLKK;VAQKKKIPQKKLKKQKLTA 3 21.3 0.95504 0.04941 0 0 0 0 0 5.30899 0 0 0 0 0 0 0 0 0 A0A8I3S5Y5 A0A8I3S5Y5_CANLF Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) PI4KB Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015] Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; rough endoplasmic reticulum membrane [GO:0030867] 1-phosphatidylinositol 4-kinase activity [GO:0004430] EQKTQRLISELSLLNHK 1 2.1 0.97878 0.046227 0 0 0 0 0 0 7.87781 0 0 0 0 0 0 0 0 A0A8I3S5Z7 A0A8I3S5Z7_CANLF "Aminomethyltransferase, mitochondrial" AMT Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] NMEGTVIGTVT;SGCPSPCLKKN 2 8.6 0.98131 0.035491 0 0 0 0 0 8.3668 0 0 0 0 0 0 4.06755 0 0 A0A8I3S602 A0A8I3S602_CANLF Cytoplasmic protein NCK1 Canis lupus familiaris (Dog) (Canis familiaris) "actin filament organization [GO:0007015]; antiviral innate immune response [GO:0140374]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine dephosphorylation [GO:1902310]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]" cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506] ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; molecular condensate scaffold activity [GO:0140693]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591] PSNYVTEEGDSPLGDHV;SKSWWRVRNSMNKTGFVPSNYV;WRVRNSMNKTGFVPSNY 3 10.3 0.98599 -0.4525 0 0 0 0 8.69798 0 0 0 10.4273 0 0 0 0 0 8.63281 A0A8I3S603 A0A8I3S603_CANLF Dpy-19 like C-mannosyltransferase 1 DPY19L1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FAGAMPTM;IVKKIISDMWGVL;LVVFIAIVKKII;TLLLPVVLVVFIAIVKKI;VINTLKRFNLY 5 6.2 1.0017 -1.2129 8.39322 6.97636 0 0 0 6.89191 0 3.46597 0 0 0 5.0654 0 0 0 A0A8I3S615 A0A8I3S615_CANLF Uncharacterized protein TMPO Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nuclear envelope [GO:0005635] DNA binding [GO:0003677] QLDLVLCRTY;SPPLAQAIRDYVNSLL;VPKVDDEILEF 3 5.3 1.0032 -1.1165 0 0 0 0 0 0 0 0 7.90833 0 0 0 0 0 9.6178 A0A8I3S625 A0A8I3S625_CANLF Leucine rich repeat containing 43 LRRC43 Canis lupus familiaris (Dog) (Canis familiaris) HLRQLCLREFPCGTGSWNKSRFLPR;SEKYQFRGLSHHGDLLACEAQ;VPLKAFLLAGTTVT 3 10 0.99238 -0.17945 9.0209 0 0 0 0 0 0 0 0 0 0 5.86498 0 0 10.8189 A0A8I3S626 A0A8I3S626_CANLF Oxidized low density lipoprotein receptor 1 OLR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] QKPNGKKAKGLH 2 14.4 1.0028 -0.79458 0 0 0 0 0 0 0 0 0 9.61134 0 0 0 0 0 A0A8I3S627 A0A8I3S627_CANLF Thioredoxin related transmembrane protein 4 TMX4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] DEEKEDLGDEEEAEEDE;EAGPEQAA 2 7.9 1.0036 -1.0582 4.44824 0 0 0 0 0 0 0 0 0 0 0 10.0976 0 0 A0A8I3S637 A0A8I3S637_CANLF Claudin-11 CLDN11 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] AEAASPRVPN;ALMIAASVLGLPAILLLLTVLPCI;LDELGSKGLWADCVM 3 13.7 1.0039 -0.81199 0 0 0 0 3.92286 7.53574 0 0 0 0 0 0 0 0 0 A0A8I3S640 A0A8I3S640_CANLF Syncytin-1 (Endogenous retrovirus group W member 1) (Syncytin) LOC102154491 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KSAASGTS;TLQNQRALDLLTAEKGG;VGLSDGGG 3 6.3 1.003 -2.1546 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4291 A0A8I3S646 A0A8I3S646_CANLF Uncharacterized protein IFNGR2 Canis lupus familiaris (Dog) (Canis familiaris) LLLLLLLL;LRNVTVGPPENVWVTPGEG;PPENVWVTPGEG;PPLLLLLL;PPLLLLLLL 5 8.6 0.93937 0.10016 0 0 0 7.97728 0 0 0 8.74319 0 0 0 0 0 0 0 A0A8I3S650 A0A8I3S650_CANLF Transcription factor TFDP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EPYVTEMAQGSIGGV 1 3.7 0.99763 -0.107 0 9.71793 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S651 A0A8I3S651_CANLF Anoctamin ANO5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane repair [GO:0001778] plasma membrane [GO:0005886]; vesicle [GO:0031982] intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983] AAKMTFIIVMEHV;AIYPMVLNWWRRRKARTNSEKLY;FILSPPCY;KPSEPPNPV;LFYEYLET;LMTIKILHDFEL;PAETFPFSYMLGP;SEECDPGG 8 10.2 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.27951 A0A8I3S655 A0A8I3S655_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" U12-type spliceosomal complex [GO:0005689] pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626] IKKEELKRSLYTL 1 14.8 0.94084 0.059723 8.62245 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S656 A0A8I3S656_CANLF Purinergic receptor P2Y14 P2RY14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled purinergic nucleotide receptor activity [GO:0045028] CRVSAVLFYVNMY 1 3.8 0.9403 0.059821 8.06523 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S664 A0A8I3S664_CANLF ADAM metallopeptidase domain 21 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] EQCVCGSFKQCYSNLCCHNDC;FKQCYSNLCCHNDC;ICQRRSICIMHK 3 4.7 0.99008 -0.21967 0 0 7.49185 0 0 0 10.8295 0 0 0 0 0 0 0 0 A0A8I3S669 A0A8I3S669_CANLF Carbonyl reductase (NADPH) (EC 1.1.1.184) CBR1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] carbonyl reductase (NADPH) activity [GO:0004090] SPEEGAESPVYLALLP 1 5.4 0.98434 -0.24265 0 0 0 0 0 0 0 0 0 0 0 9.4018 0 0 0 A0A8I3S673 A0A8I3S673_CANLF PLAG1 zinc finger PLAG1 Canis lupus familiaris (Dog) (Canis familiaris) gland morphogenesis [GO:0022612]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; prostate gland growth [GO:0060736] centrosome [GO:0005813]; cytosol [GO:0005829]; nuclear speck [GO:0016607] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ETKPRKNFPCQLCDK;GVPSSSQDSQASSSKLG 2 6.4 0.93815 0.10012 0 0 0 5.93298 0 0 0 0 9.70719 0 0 0 0 0 0 A0A8I3S674 A0A8I3S674_CANLF Metallothionein LOC119877135 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DLNCSCSTSGSCIYAGPCKCRV 1 33.8 0.97351 0.046699 0 0 0 0 0 0 0 0 5.58586 0 0 0 0 0 0 A0A8I3S676 A0A8I3S676_CANLF Calpain catalytic domain-containing protein CAPN7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] CHMRTSRDYALLSPAQSREP;HTHSLTPACASR;LYTEAVDLCLKTSYETADKTLQ;PYTHTHTHTHTH;SPFLERPQPFISPQSC;TSRDYALLSPAQSREP 6 8 0.98909 -0.31207 0 0 0 0 5.77379 0 0 0 5.4546 0 11.3605 0 6.54814 9.86262 0 A0A8I3S680 A0A8I3S680_CANLF TATA-box binding protein associated factor 5 TAF5 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123] actin cytoskeleton [GO:0015629]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276] identical protein binding [GO:0042802]; RNA polymerase II general transcription initiation factor activity [GO:0016251] FADSTVRVWSV;FGLLKEPEIEVP;KQQIDAMVGS;KRVRLGPDC;LMVGELKGHTDTV;PLDDEDEEGEN;TDHYQPLRIF;VLSAYNQQGDPT;WNIVQEHLYIDIFDGMPRSKQQIDA 9 13.2 1.0023 -0.71334 0 0 8.34367 11.5544 5.96578 0 0 0 10.1629 8.88795 11.1525 8.64364 0 0 0 A0A8I3S698 A0A8I3S698_CANLF Cell division cycle associated 3 CDCA3 Canis lupus familiaris (Dog) (Canis familiaris) SCDPAADPVVMARED 1 6.9 0.95293 0.053902 0 0 0 0 0 0 0 0 0 0 0 12.7667 0 0 0 A0A8I3S6A4 A0A8I3S6A4_CANLF Proenkephalin-A PENK Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] chromaffin granule lumen [GO:0034466]; extracellular region [GO:0005576] opioid peptide activity [GO:0001515] ATVRAECGQDCATC;EESHALAK;GGFMKKMDELYPQE;PGAHLAAS;VGRPEWWMDY 5 10.5 0.98941 -0.26592 0 0 0 0 11.5319 0 0 0 0 0 0 0 0 0 0 A0A8I3S6A9 A0A8I3S6A9_CANLF Uncharacterized protein MAMLD1 Canis lupus familiaris (Dog) (Canis familiaris) ESFLPSSSFAHELARVTSSHST;GVKSPPGHL;PGPSPSYRPVPSPHPPPPPP 3 6.8 1.0034 -1.0355 0 5.43819 8.97708 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S6B5 A0A8I3S6B5_CANLF Phospholipid phosphatase 1 (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) PLPP1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644] apical plasma membrane [GO:0016324]; caveola [GO:0005901] phosphatidate phosphatase activity [GO:0008195] LFGAAASQSLTDIAKYSIG;MVKYGSNASMPMAVLNLSQIYPFQR 2 16.1 0.98423 -0.24276 9.47585 0 0 0 0 0 0 0 0 0 0 0 0 10.2065 0 A0A8I3S6C0 A0A8I3S6C0_CANLF ERBB receptor feedback inhibitor 1 ERRFI1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; bile acid biosynthetic process [GO:0006699]; cartilage development [GO:0051216]; cell migration [GO:0016477]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; chondrocyte proliferation [GO:0035988]; embryo implantation [GO:0007566]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation [GO:0050673]; fat pad development [GO:0060613]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; limb joint morphogenesis [GO:0036022]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; lung epithelium development [GO:0060428]; lung vasculature development [GO:0060426]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of protein autophosphorylation [GO:0031953]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; progesterone receptor signaling pathway [GO:0050847]; protein localization to plasma membrane [GO:0072659]; regulation of keratinocyte differentiation [GO:0045616]; response to 1-oleoyl-sn-glycerol 3-phosphate [GO:1904565]; response to estradiol [GO:0032355]; response to insulin [GO:0032868]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; skin morphogenesis [GO:0043589]; tissue homeostasis [GO:0001894]; uterine epithelium development [GO:0035847] cytosol [GO:0005829]; plasma membrane [GO:0005886] protein kinase binding [GO:0019901] LQRQNSEGS;LSVNGVCASPPP;MSTAGVAA;PLKTGYLHDGQA 4 9.1 1.0031 -1.3274 7.42719 0 0 0 6.27079 0 8.32003 0 0 0 0 0 0 0 0 A0A8I3S6C4 A0A8I3S6C4_CANLF Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) LOC612587 Canis lupus familiaris (Dog) (Canis familiaris) translation initiation factor activity [GO:0003743] KKKKKKKK;KKKKKKNVKFP 2 6.5 0.98151 0.035491 0 0 0 0 5.65484 0 0 0 0 0 0 0 0 0 0 A0A8I3S6C6 A0A8I3S6C6_CANLF 26S proteasome non-ATPase regulatory subunit 2 PSMD2 Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] "nucleus [GO:0005634]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]" enzyme regulator activity [GO:0030234] IVPYNMAH;SIFGLGLAYAGS 2 2.7 1.0022 -0.76746 0 0 0 0 0 0 0 0 0 0 0 0 9.87779 0 0 A0A8I3S6D1 A0A8I3S6D1_CANLF Nucleoredoxin like 1 NXNL1 Canis lupus familiaris (Dog) (Canis familiaris) photoreceptor cell maintenance [GO:0045494] GGRGAEGG;SQDPTEEQQDLFLRDM;VLIRNNSDQD 3 16 0.98788 -0.48729 0 0 11.1291 8.545 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S6D5 A0A8I3S6D5_CANLF Protein GOLM2 (Golgi membrane protein 2) GOLM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DIHHLKEQLAELRQEFLRQ;LAYNEEEDGDGGEED 2 8.3 0.93858 0.10358 0 0 0 0 0 8.57376 0 0 0 0 0 0 0 7.39994 0 A0A8I3S6D6 A0A8I3S6D6_CANLF Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) USP37 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] ATELSLQEFNN;CLDSDSEDELKRSVALSQRLC;FDGMSEEELLAA;ICTRRSLMNCWKRKRILR;LSQCLDQLKED;LVRHKFNRLPRILILHLKRYSFNV;RLPRILILHLKRYS 7 10.3 0.99554 -0.017364 6.83567 0 4.00387 0 0 8.43321 7.98817 0 0 2.99693 0 0 0 0 6.98311 A0A8I3S6E3 A0A8I3S6E3_CANLF Killer cell lectin like receptor F2 KLRF2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein homodimerization activity [GO:0042803] YKGFSLYLQ 1 4.6 1.0033 -0.80421 0 0 0 0 0 0 0 0 0 0 7.67553 0 0 0 0 A0A8I3S6E4 A0A8I3S6E4_CANLF Solute carrier family 38 member 1 SLC38A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] L-glutamine transmembrane transporter activity [GO:0015186] NDSNKFISDRESRRSLTNSH 1 4.3 0.95496 0.049417 0 0 0 0 0 0 0 0 5.32012 0 0 0 0 0 0 A0A8I3S6F0 A0A8I3S6F0_CANLF "Ribonucleoprotein, PTB binding 1" RAVER1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GAGGGGGG;GERSGGGG;IQKRLEHTERQFRNRRKILIRGL;LPDSYGFDYP;QGLGGHYAD 5 7.9 1.0032 -1.9415 0 0 3.27265 10.7543 0 0 9.70061 0 0 0 0 0 10.358 0 0 A0A8I3S6F1 A0A8I3S6F1_CANLF Adhesion G protein-coupled receptor G2 ADGRG2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] EEILLMFKIFLI;EIVHTSSI;GVSSSSNS;TLQTLSETYFIVCATAEAQ;TYIRKYILK;YSNGTPDAT 6 6.5 1.0032 -2.3963 0 0 0 0 9.58988 0 5.24876 0 0 0 0 9.08584 0 0 8.69122 A0A8I3S6F8 A0A8I3S6F8_CANLF Calcium homeostasis modulator 1 CALHM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic cation channel activity [GO:0005261] GFPPAHAT;HYCSPLSYRQEAYWAQY 2 7.7 0.98921 -0.26592 0 0 0 0 0 0 0 0 0 0 0 12.478 0 0 0 A0A8I3S6G7 A0A8I3S6G7_CANLF Solute carrier family 16 member 5 SLC16A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] SSFCRTLSQLYLTA;YTEIMYVTSV 2 5.3 0.98632 -0.25972 9.04971 9.43083 0 10.1308 0 9.4169 10.5326 9.60112 9.74796 0 8.96737 8.93068 9.28621 8.73478 10.3049 A0A8I3S6H2 A0A8I3S6H2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LKRKIDLRVWIVVFQ 1 5.8 0.95686 0.053874 0 0 0 0 4.13685 0 0 0 0 0 0 0 0 0 0 A0A8I3S6H6 A0A8I3S6H6_CANLF Anaphase promoting complex subunit 7 ANAPC7 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979] anaphase-promoting complex [GO:0005680]; heterochromatin [GO:0000792]; spindle [GO:0005819] enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903] DVDDMEGSGEEGDLEGSDSE;GQERPSVTSYKEVLRQ;QCLPSEIEVKYKMAECYTMLKQ;VYHADSLFHDKEYR 4 12 0.99284 -0.032206 0 5.94652 7.82107 0 0 9.18202 0 0 0 0 0 0 0 0 0 A0A8I3S6I2 A0A8I3S6I2_CANLF Septin SEPTIN14 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] DVGPDNKPLSFQEIYEAKRQKFYD;KIKRSFTDYH 2 8.2 0.99781 -0.60038 0 0 0 0 0 0 0 0 10.841 0 0 0 0 0 0 A0A8I3S6I3 A0A8I3S6I3_CANLF Intraflagellar transport protein 122 homolog IFT122 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512] ciliary basal body [GO:0036064]; intraciliary transport particle A [GO:0030991] DRKMFKEA;GVTDTDWHELAMEA;KAELCIYDLAFKPD;MCAYYFKKLDNP;PDASITMCPSCFQMFHSEDYEL;VGCQDGTI 6 6.3 1.0011 -0.9233 9.39962 0 0 0 4.8503 6.27659 0 0 0 0 4.32855 0 9.1199 0 0 A0A8I3S6J7 A0A8I3S6J7_CANLF Pseudouridine synthase 7 PUS7 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] DNLEGKPPPV;KDTMDAINVLSK;TATYIDEEDVNNY;VMPLPGFDVIYPKH 4 8 0.98654 -0.42527 7.46932 0 0 9.64306 0 8.11764 0 0 0 0 0 0 0 0 0 A0A8I3S6J9 A0A8I3S6J9_CANLF Inhibitory synaptic factor 1 INSYN1 Canis lupus familiaris (Dog) (Canis familiaris) inhibitory postsynaptic potential [GO:0060080] postsynaptic density [GO:0014069] GGGPAKGQ;VDGAEPSRP 2 5.9 1.0021 -1.2975 0 0 0 0 0 8.42114 0 0 0 0 0 7.29847 10.859 0 0 A0A8I3S6K0 A0A8I3S6K0_CANLF C-type lectin domain-containing protein CLEC2D Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] EANFVPVDLLATPN;ILILILIFLILTVLGLIT;ILILILIFLILTVLGLITG;INQNRILVILILILIFLILTVL;LILILIFLILTVLGLITGLLV;LVILILILIFLIL;NQNRILVILILILIFLIL;NRILVILILILIFLI;PESWIGFQRKCFYF;RILVILILILIFLILTVLGLI;VILILILIFLIL;VILILILIFLILTV;VILILILIFLILTVL;VILILILIFLILTVLGL 14 28.9 0.95359 0.050445 4.52067 0 5.70714 0 7.90147 8.92733 5.24352 5.62915 6.64847 0 0 4.22797 0 0 5.60098 A0A8I3S6K9 A0A8I3S6K9_CANLF Anoctamin ANO8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTRLPAFLSFKFL;EDFIYENVESELRF;EEEEEDDEEEGEESG;GGGGGGSG;LEYQRREAFKRHERQAQHRYQQQQR;LKKVSFAE;LSGGCGAP;PFGGARADTGSNGAGGQARLD;TSSAGGTS;VLSLSQSLERQL 10 11.5 1.0024 -2.5892 0 0 8.6335 9.75402 9.28126 0 10.0511 10.6012 11.3879 0 0 9.62066 0 9.56175 0 A0A8I3S6M0 A0A8I3S6M0_CANLF TBC1 domain family member 21 TBC1D21 Canis lupus familiaris (Dog) (Canis familiaris) IDKKRLEKIL;LLENLHRNFMETRTTIAYD;LVAYSMLQM;SYVCNTQAEYQQ 4 16.7 1.0013 -1.3154 0 9.85753 0 0 0 0 0 8.80471 0 6.69363 0 0 8.98581 0 0 A0A8I3S6M2 A0A8I3S6M2_CANLF Arginine-glutamic acid dipeptide repeats RERE Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714] AGPHPFAS;DLSSASEDDFDSEDSEQEL;GHMRPSFEPPPTTIA;PGAIPPPMSAAH;RSSGRNSPSAASTSSNDS;SLSTHHPPSAHPPPLQ;TSQLPTPGP 7 7.6 1.0036 -2.2461 0 0 5.5256 0 0 0 10.4176 10.764 4.9656 0 5.20758 7.78051 0 0 8.02769 A0A8I3S6N3 A0A8I3S6N3_CANLF Synembryn (Protein Ric-8) RIC8A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085] DTDEYKEAKARTVRVWSC 1 3.2 0.97754 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.68322 A0A8I3S6N6 A0A8I3S6N6_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1E" PPM1E Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; positive regulation of stress fiber assembly [GO:0051496] nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991] metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] AATVAATE;DLTQIEASKPHSA;FPHDPAEALCRAFRVT 3 4.9 1.0027 -1.3246 0 0 0 11.8087 0 0 0 0 0 0 0 0 10.1316 0 7.4591 A0A8I3S6P3 A0A8I3S6P3_CANLF Interferon induced protein with tetratricopeptide repeats 5 IFIT5 Canis lupus familiaris (Dog) (Canis familiaris) response to other organism [GO:0051707] LENITDDHKHQIH 1 2.7 0.98953 -0.22229 9.19089 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S6Q7 A0A8I3S6Q7_CANLF Dpy-19 like 2 DPY19L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FAGAMPTM;LSSYYSSSLLMT;VQDKDYNGLILILI;YSSSLLMT 4 4.6 1.002 -0.67645 0 0 0 4.91667 0 0 0 0 0 0 9.84699 0 0 0 0 A0A8I3S6Q8 A0A8I3S6Q8_CANLF Transcription factor TFDP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EDEEDDEEDS;ETPCSFNDEDEEDDEEDSSS;FNDEDEEDDEE;NDEDEEDDEEDSSSP;PTNSAQECQNLEIE 5 10 0.98584 -0.41281 8.20178 0 10.2502 0 0 0 0 0 5.7205 0 0 3.93093 0 6.1356 7.00034 A0A8I3S6R0 A0A8I3S6R0_CANLF Alpha-2-macroglobulin A2M Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EREESPFALEVQTLPQTCDRPK;LAKPEAEL;LAKPEAELSAASVYNLL;LFASPVVSELQ;LQRSHELTD;LVSSGPFFLQHEEKQ;RLFASPVVSELQ;SLSFMVLQDVP;TDEFAIAEYN;VDDDNRLLLQQT;VHFSEPLTE;YSGTFFTK 12 8.5 0.95098 0.053901 0 0 0 0 0 0 7.85037 0 0 0 0 0 0 0 0 A0A8I3S6R4 A0A8I3S6R4_CANLF Thrombopoietin THPO Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; thrombopoietin-mediated signaling pathway [GO:0038163] extracellular region [GO:0005576] cytokine activity [GO:0005125]; hormone activity [GO:0005179] TWTLEWNSWTPS 1 4.2 0.95331 0.05044 0 0 0 0 0 0 6.8392 0 0 0 0 0 0 0 0 A0A8I3S6S1 A0A8I3S6S1_CANLF Spartin SPART Canis lupus familiaris (Dog) (Canis familiaris) YGHTAGEA 1 1.3 0.98832 -0.26458 0 0 0 8.19849 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S6S3 A0A8I3S6S3_CANLF Kinesin family member 24 KIF24 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AQAEDLDDSDFSEDSFSHVS;GVRDMNDRKRLFQLIKIIKIM;LFVWISFYEIYCG;LPALSPSPI;LTVSLLENTDDEGPLPSE;NVTMKDYSKLGVRDMNDRKR;SQDGAQAEDLDDSDF;SRQNTSEKENPWTE 8 8.1 1.0032 -0.89232 0 0 0 11.0105 0 0 0 0 0 0 0 8.45442 0 4.73129 14.0659 A0A8I3S6U1 A0A8I3S6U1_CANLF Otoferlin OTOF Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] AGDLLAAF;EAYCPPRFPPQLEYYQ;ELTSSTEV;GLARNEPDPLEKPNRPDTA;HYHSLTGEGNFNWRYLFPFDYL;IDSNEILEIQ;KSSDIFVRGWLKGQQEDK;KWLIIKIVLALLGLL;LIIKIVLALLGLLML;LLQIGPAGKADLPP;MKEQLRQQEVSGTDLE;NTDEVVLEDDDFFT;PSEIEDENGQRKPT;TDRNYFHLPYLERKPCIYMKSW;VLEDDDFFTGE;WPVASNIDSNEILEIQI;YLWLGLSKQRKDFLC 17 11.1 0.98953 -0.21547 0 0 0 0 0 0 0 0 0 0 0 0 10.3244 0 12.456 A0A8I3S6U6 A0A8I3S6U6_CANLF Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] SKKAVLKG 1 5.6 0.99001 -0.26592 0 0 0 0 9.99421 0 10.2289 0 0 0 0 0 0 0 0 A0A8I3S6V4 A0A8I3S6V4_CANLF OFD1 centriole and centriolar satellite protein OFD1 Canis lupus familiaris (Dog) (Canis familiaris) EIKLNEYKKEIEQQ;LLPHYRSPPP;NVLHPAGDMPHMDAAAAAVSFHYP;SEAFISRER;VNTKMRVKELE;YKSLISGFDK 6 6 1.0031 -1.3325 0 10.47 0 0 0 0 0 9.58259 0 0 6.73268 0 0 0 9.37567 A0A8I3S6V7 A0A8I3S6V7_CANLF DUF1725 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEMYEWIKKMWSMYTM 1 19 0.95517 0.049233 0 0 0 0 0 0 0 5.09828 0 0 0 0 0 0 0 A0A8I3S6W4 A0A8I3S6W4_CANLF Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) KARS1 Canis lupus familiaris (Dog) (Canis familiaris) basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of macrophage activation [GO:0043032] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP:ADP adenylyltransferase activity [GO:0003877]; lysine-tRNA ligase activity [GO:0004824]; tRNA binding [GO:0000049] DVGAEEESLDPNQYFKIRSQAIHQL;GEDPYPHKFHVDISLTHFI 2 7.4 0.98388 -0.24464 12.2767 8.49566 0 0 0 0 0 10.9391 0 0 0 0 0 0 0 A0A8I3S6X4 A0A8I3S6X4_CANLF DnaJ heat shock protein family (Hsp40) member C17 DNAJC17 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] RNA binding [GO:0003723] EEESRSTRTLEQEIE;GSDDEEESRSTRTLE;KGGYSRDVLLQLFQKYG;LVMMRMRQAAERQ 4 16.1 0.988 -0.37449 0 0 8.24174 0 0 6.22905 0 6.73444 0 0 0 0 0 9.99365 0 A0A8I3S6Y3 A0A8I3S6Y3_CANLF Uncharacterized protein DZIP1L Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cell projection [GO:0042995]; centriole [GO:0005814]; cytoplasm [GO:0005737] metal ion binding [GO:0046872] DEFKSVAKHNS;DVATLQENIIHV;LQALKEKMIIQKTEWKRKMKELQ;PALLKLVRL;QELERQAQEF 5 12.1 1.0033 -1.5741 8.50084 0 9.52074 10.1119 0 8.75134 0 0 10.2364 9.34087 3.66494 0 0 0 0 A0A8I3S6Z0 A0A8I3S6Z0_CANLF "Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1" PREX1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; neutrophil chemotaxis [GO:0030593]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; reactive oxygen species metabolic process [GO:0072593]; T cell differentiation [GO:0030217] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] DPRGPGAAAPGSGP;EINTQSLEKVQQYY;GVAITGATGLEK;LPSRLEGGASL;LRVSRGSGDLP;VLEHFQAFRSHQEEALGLYQWV 6 5.6 0.98257 -0.25104 0 0 0 0 0 0 0 0 4.98035 0 0 0 0 0 0 A0A8I3S6Z1 A0A8I3S6Z1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GAHAGGVAARGGGAP;GRGGGGAH;GVGRGGGG;VGRGGGGAH 4 8.3 1.002 -1.8339 0 0 8.24973 0 0 9.11069 0 0 0 9.80253 0 9.35568 9.14759 0 8.96509 A0A8I3S702 A0A8I3S702_CANLF glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) QARS1 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873] aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829] ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860] DETKGFHQIPFGS;DIQVPNFPADETKGFHQIP;GEATLRMKLVMED;HWVSQPLTCEIRLYERLFQHK;VYCPVQWEYGRLNLHYAV 5 9.5 0.98806 -0.34239 6.45848 0 0 10.6671 0 9.67999 0 0 0 0 0 0 0 0 5.99977 A0A8I3S714 A0A8I3S714_CANLF Ninein like NINL Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] calcium ion binding [GO:0005509] GRSQTETWELLRGTEGNASP;GVGSSGHL 2 2.1 1.0028 -1.3529 0 8.94956 0 0 0 10.2701 0 0 0 0 0 0 0 0 0 A0A8I3S718 A0A8I3S718_CANLF Putative nucleotidyltransferase MAB21L1 (Protein mab-21-like 1) MAB21L1 Canis lupus familiaris (Dog) (Canis familiaris) camera-type eye development [GO:0043010]; cell population proliferation [GO:0008283]; positive regulation of cell population proliferation [GO:0008284] nucleus [GO:0005634] AWVLQFAEAENR 1 3.3 0.99474 -0.15736 0 0 9.96723 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S727 A0A8I3S727_CANLF Uncharacterized protein ZKSCAN7 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" FQRHLSGP;GEKPYECNECGKAFSR;GPQEALSRLRELCRWWLM;GTLGLIPRGAVFQ 4 7.3 1.0021 -1.2462 8.52003 0 0 6.51287 0 0 0 7.75969 0 0 0 0 0 0 0 A0A8I3S730 A0A8I3S730_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) NEDD4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; formation of structure involved in a symbiotic process [GO:0044111]; innate immune response [GO:0045087]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection development [GO:0031175]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755] cell cortex [GO:0005938]; chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] beta-2 adrenergic receptor binding [GO:0031698]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630] AAEMEQGFLPKG;AIHSGSLSNFSTS;EPSPLPPGWEERQDILGRTYYVN;FNRLDLPPYE;LHKPITLHDMESVDGE;QAEELEPGWVVLDQP;QATVETSQLQPSQSA 7 7.9 1.0046 -1.0515 0 10.1573 9.44205 6.58817 9.40512 7.23122 10.5832 0 0 0 0 8.76195 0 10.3211 0 A0A8I3S738 A0A8I3S738_CANLF Solute carrier family 18 member A1 SLC18A1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of localization in cell [GO:0051649]; neurotransmitter transport [GO:0006836]; serotonin transport [GO:0006837] synaptic vesicle membrane [GO:0030672] xenobiotic transmembrane transporter activity [GO:0042910] LVNPFVGP;VSPESARGTPLLT 2 4.4 1.0023 -0.76509 0 8.26688 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S758 A0A8I3S758_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HUWE1 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein ubiquitination [GO:0031398]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209] cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654] histone ubiquitin ligase activity [GO:0140852] AASTTVTT;DDEGEEGDEDDDDDGSEMELD;DDQEDDEGEEGDEDDDDDGSEM;DEEEEEEEDEEDDQEDD;DEGEEGDEDDDDDGSEM;DEGEEGDEDDDDDGSEME;DERKYPYH;DLIIEFDNMFSS;EDDQEDDEGEEG;EEEEEEDEEDDQEDDEGEEGDED;EEEHTQEED;EEEHTQEEDSSGS;EEGDEDDDDDGSEMELDE;EEGLEDAANV;EGEEGDEDDDDDGSE;EGEEMETDMDGVQ;ESPEEVAC;GHNALFETFN;LSEQLSLDELWDMLGE;NLPIDFPTSAA;QSSDFDTQSGFSIN;RQRRSHHAA;SNEDEDDSQDEEEEEEEDEEDDQ;SQDEEEEEEEDEEDDQEDD;TEKLLRLLSLISIALPENK;TPLVTLLLRH;VHLERTPKLS;VIRRSSLLTEKLLRLLSLISI;YHWVDLLDRFDGIL;YSSATAKTQHN 30 5.7 0.93936 0.059582 0 0 0 3.40558 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S768 A0A8I3S768_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) HECTD2 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] ISIAAKKIIIQRDSEQQ;LDHIDLMEEYHTWQSFG;LVERLLQFISLRLFP;VPSPAAPPELAAAAPE;VTTDDLCQIMPEL 5 10 0.94523 0.077515 8.19702 6.47345 0 5.27824 0 0 0 0 0 4.8677 0 0 16.2573 0 0 A0A8I3S779 A0A8I3S779_CANLF Tectorin beta TECTB Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886] VILVFCYPKTIITKI;VIPDLSPK;YSFSAHLIGTEGERQTDVSPAIP 3 13.5 1.0024 -1.0041 0 0 0 6.54384 0 0 8.29765 7.92416 0 0 0 0 0 0 0 A0A8I3S783 A0A8I3S783_CANLF UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) SLC35A5 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165] LEYAPRQERVRDL;SIPAFLYFLDNLIVFYVISYLQ 2 8.4 0.98925 -0.19685 0 0 0 0 0 0 9.48949 8.56327 0 0 0 4.68868 0 0 0 A0A8I3S794 A0A8I3S794_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP21 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886] cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784] HGGGGGAK;HVISARPSE;RRLGGFPGPPTL;TNLARSKSVS 4 5.1 1.0022 -1.228 0 0 0 0 0 7.66654 0 0 0 12.4635 0 0 0 0 0 A0A8I3S7A5 A0A8I3S7A5_CANLF Collagen type XXV alpha 1 chain COL25A1 Canis lupus familiaris (Dog) (Canis familiaris) DPGSSAAG;VHLLPDCLDQLKA 2 3.3 1.0029 -1.3782 0 7.8695 0 0 0 9.39949 0 0 0 0 0 0 0 0 0 A0A8I3S7B1 A0A8I3S7B1_CANLF Bridging integrator 1 BIN1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of endocytosis [GO:0030100] plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021] phospholipid binding [GO:0005543]; tau protein binding [GO:0048156] GFMFKVQAQ;GVKESDWNQHKE;LPKSPSQLR;PSQTAEPG 4 6.8 0.94265 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.41295 0 A0A8I3S7B3 A0A8I3S7B3_CANLF "SEC24 homolog D, COPII coat complex component" SEC24D Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] ATLDYCRNKP;GAHAQGHPPQ;LDPDSIPSPIQ;VTDVGEVFVPLLDGFLVNYQESQS 4 5.3 1.0018 -0.74238 0 0 7.30588 0 0 0 0 0 0 0 0 0 0 8.15669 0 A0A8I3S7C5 A0A8I3S7C5_CANLF Family with sequence similarity 120C FAM120C Canis lupus familiaris (Dog) (Canis familiaris) GGPGKGHG;GPGKGHGK;ILEGVNMNH;ILHRHELDTFLA;QPPSSPRRPRSF;SLGDGEPHIPSL;VHSGLELL 7 3.6 1.0024 -1.8672 9.84051 0 0 0 0 0 11.5762 0 0 11.231 11.4918 10.0979 12.7411 0 9.92117 A0A8I3S7E1 A0A8I3S7E1_CANLF Meiotic recombination protein DMC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombinase assembly [GO:0000730]; DNA strand invasion [GO:0042148]; double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; mitotic recombination [GO:0006312]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; spermatid development [GO:0007286] "chromosome, telomeric region [GO:0000781]; lateral element [GO:0000800]; site of double-strand break [GO:0035861]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697] AGGYSGGK;IDTENTFRPDRLRD;RIAKIYDSP 3 9.1 0.98852 -0.50591 10.5559 0 0 0 0 0 0 0 0 0 0 0 0 6.1189 0 A0A8I3S7E7 A0A8I3S7E7_CANLF THAP domain containing 7 THAP7 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607] C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; general transcription initiation factor binding [GO:0140296]; histone deacetylase binding [GO:0042826]; histone reader activity [GO:0140566]; identical protein binding [GO:0042802]; lysine-acetylated histone binding [GO:0070577]; methylated histone binding [GO:0035064]; phosphorylated histone binding [GO:0106153]; transcription corepressor binding [GO:0001222] EASAPAAL 1 2.6 0.98968 -0.2632 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85339 A0A8I3S7E8 A0A8I3S7E8_CANLF UBX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] nucleus [GO:0005634] ubiquitin binding [GO:0043130] AAIRASLQETHFDSTQ 1 7.9 0.96109 0.049233 0 0 0 0 0 9.17415 0 0 0 0 0 0 0 0 0 A0A8I3S7F0 A0A8I3S7F0_CANLF Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) UBA1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] mitochondrion [GO:0005739] ATP binding [GO:0005524]; ubiquitin-like modifier activating enzyme activity [GO:0008641] ESPLHLSPARA;FQVVVLTNTPLEDQLRVGE;GKNRAEVSQPRLAE;VLGPYTFSIC;YVLGHEAMKRL 5 7.8 0.98155 0.035491 0 0 0 0 0 0 0 0 6.97831 0 0 0 0 0 0 A0A8I3S7F1 A0A8I3S7F1_CANLF H/ACA ribonucleoprotein complex subunit RRH Canis lupus familiaris (Dog) (Canis familiaris) snoRNA guided rRNA pseudouridine synthesis [GO:0000454] box H/ACA snoRNP complex [GO:0031429] box H/ACA snoRNA binding [GO:0034513] DQGPPEHVVLLGEFL;GGRGGGGG;PYFNAPVYLENKEQIGKVDEIF;RGGGGGGF;TDENKVPYFN 5 25.2 0.94863 0.056059 8.58429 0 0 0 0 0 0 8.56689 10.0904 0 0 0 0 0 0 A0A8I3S7F5 A0A8I3S7F5_CANLF Flagellum associated containing coiled-coil domains 1 FLACC1 Canis lupus familiaris (Dog) (Canis familiaris) DEMFDKKKRSQSDIMNRF;QLLTEENIHLR;TDIITDLEDQISELTV 3 11.7 0.98653 -0.45049 0 0 0 8.02614 0 0 0 12.2256 0 0 0 0 0 10.9695 0 A0A8I3S7G5 A0A8I3S7G5_CANLF Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (Peptidase M) (p67) (p67eIF2) METAP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] ATGKKKKKKKKKR;ATGKKKKKKKKKRGPK;GATGKKKKKKKKKRG;GATGKKKKKKKKKRGPKVQT;GKKKKKKKKKRGPKVQ;KKKKKKKK;KKKKKKKKKRGP;KKKKKKKKKRGPK;TDGDGDGD 9 6.3 1.0031 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 4.40347 0 A0A8I3S7H2 A0A8I3S7H2_CANLF Calcium voltage-gated channel auxiliary subunit alpha2delta 4 CACNA2D4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVSERPQEPPKNKAIQ;PPKNKAIQI;SEDMEAML 3 3.2 0.98799 -0.47144 0 0 0 0 0 0 9.93586 0 9.45853 9.67402 0 0 0 0 0 A0A8I3S7H6 A0A8I3S7H6_CANLF Adhesion G protein-coupled receptor L1 ADGRL1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] axon [GO:0030424]; presynaptic membrane [GO:0042734] G protein-coupled receptor activity [GO:0004930]; latrotoxin receptor activity [GO:0016524] AGEAGTGGPGGASLVV;HTRGSIYAGDVSSSVKLMEQ;PAPSTRRPPAPNLH;PGGGGEEE;SIYAGDVSSSVKLME;TGAQMTRSVT;VKLAGEAGTGGPGGASL;WNYSERSMLGYWSTQGC 8 6.1 1.0017 -2.6307 0 11.1193 8.3102 0 11.6294 0 11.5895 0 11.5322 6.65263 0 7.21267 0 11.8893 0 A0A8I3S7H7 A0A8I3S7H7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TSSK1 TSSK1B Canis lupus familiaris (Dog) (Canis familiaris) spermatid development [GO:0007286] motile cilium [GO:0031514] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] DAAVLKQRGYIMGINLGEGSYAKVK;IDRKKAPKDFLEK;LDKDFNIKLSDFG 3 13.8 0.85781 0.15483 0 0 0 0 0 0 9.07403 0 0 0 0 0 0 0 10.1093 A0A8I3S7I4 A0A8I3S7I4_CANLF Decapping mRNA 1B DCP1B Canis lupus familiaris (Dog) (Canis familiaris) VGYFNGSLTPQTL 1 3.4 0.98494 -0.2577 0 0 0 0 0 0 0 0 0 0 0 0 0 9.69164 0 A0A8I3S7I6 A0A8I3S7I6_CANLF Neurexin 2 NRXN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] AEQDDSDCE;AEQDDSDCEE;CAEPATLQLDTPAA;EPATLQLDTPA;IITEDSLDPP;LDGGQMKLTV;LDLESELYLGGLPEGG;LEECEPSTGGEL;LLDSGTSWSSAR;NSGNGNDFIVIELVKGYIH;PAGGPCQAEQDDSDCE;PPSPSPPPPLPLLLLLLTL;TEDSLDPPPVATRSP;TPAADDRWHMVL 14 8.9 1.0029 -2.501 12.655 9.39827 7.77946 8.87252 0 0 9.47626 9.29781 0 0 10.0522 0 10.2617 0 9.09138 A0A8I3S7I7 A0A8I3S7I7_CANLF Bcl-2 Bcl-2 homology region 1-3 domain-containing protein BOK Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] AAGGCWGSAARTAR;AGAGGCGDT;GPAGQELPGRDRPSLPRPRA;VHPGLPAWHAAR 4 12 1.0021 -1.2441 0 0 7.72785 0 0 6.00834 0 0 0 10.376 0 0 0 0 0 A0A8I3S7J4 A0A8I3S7J4_CANLF Islet cell autoantigen 1 ICA1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transport [GO:0051049] Golgi apparatus [GO:0005794] protein domain specific binding [GO:0019904] EPAKAASDLTAWFSLF 1 3.3 0.98507 -0.25797 0 0 0 0 0 0 0 0 10.6174 0 0 0 0 0 0 A0A8I3S7J9 A0A8I3S7J9_CANLF DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) APEX2 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; zinc ion binding [GO:0008270] QLKILRFLVHHKQDP 1 2.9 0.95145 0.053874 0 0 0 0 0 0 4.68566 0 0 0 0 0 0 0 0 A0A8I3S7K2 A0A8I3S7K2_CANLF Synaptotagmin 16 SYT16 Canis lupus familiaris (Dog) (Canis familiaris) DEEQGNDWRQEDANPLFLEVDHF;RNLAVNRAPDTYGKL;SIRRGQPNPVYK;VGNSRHHGTSP 4 9.5 0.97889 0.046253 0 0 5.13134 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S7L7 A0A8I3S7L7_CANLF Immediate early response 2 IER2 Canis lupus familiaris (Dog) (Canis familiaris) cell motility [GO:0048870]; positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleoplasm [GO:0005654] EAPRAEETPARCAPR 1 6.8 0.95333 0.053883 0 0 0 0 0 0 6.08613 0 0 0 0 0 0 0 0 A0A8I3S7N7 A0A8I3S7N7_CANLF Spt20-like SEP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SAGA complex [GO:0000124] transcription coregulator activity [GO:0003712] ATPVTATS;AVAGACSPRQ;GVFGYEGGREPQTT;LEKLVRRES;LLRPTMQTLACDMQSITSDGQQW;SGSPTTTT;SLSVACAANRLLYN 7 10.9 1.0029 -1.7158 0 0 0 0 0 7.95152 0 0 0 0 10.3898 0 0 0 0 A0A8I3S7P0 A0A8I3S7P0_CANLF DEAD-box helicase 17 DDX17 Canis lupus familiaris (Dog) (Canis familiaris) "alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; miRNA metabolic process [GO:0010586]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]" cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; ribonucleoprotein complex [GO:1990904] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; mRNA 3'-UTR binding [GO:0003730]; ribonucleoprotein complex binding [GO:0043021]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713] EYGAGTYGASSTTSTGRS;GGGGGGKGG;GGGGGKGG 3 3.7 1.0027 -0.7559 0 0 11.8876 0 0 0 0 0 0 11.9568 11.9966 0 12.2449 4.88484 0 A0A8I3S7P1 A0A8I3S7P1_CANLF Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain domain-containing protein AP1B1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin adaptor complex [GO:0030131] ATEQQHLHSRQEERGRPGYALPVPE;ILFVEDGKMDRQMFLATWKD;IRDCPLNAGCEQQATEQQH;NYVVQEAIVVIKDIFRKY;VGSISMDLQ;VLMKFMEMLSKDLDYY 6 11.2 1.0024 -1.1518 10.1393 8.37478 0 9.73256 0 8.78865 0 8.52133 9.52007 0 8.54605 0 0 0 0 A0A8I3S7P3 A0A8I3S7P3_CANLF dual-specificity kinase (EC 2.7.12.1) DYRK4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] FSLSIVRRFTLSVLKCLQMLYVE;PLAQAQKPPSKIK;RVRPPGAA;SPGKQSKNSSPK;VLGYTELWF 5 9.5 1.0035 -1.6362 0 0 10.2626 8.01173 0 6.86604 0 0 0 0 0 0 0 0 0 A0A8I3S7P6 A0A8I3S7P6_CANLF Growth arrest specific 2 like 1 GAS2L1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] SVVLCLLEVARRGARLG;TPPGPASD 2 3.9 0.98773 -0.48794 0 0 0 10.0154 0 0 0 0 0 0 0 0 0 0 9.0038 A0A8I3S7Q3 A0A8I3S7Q3_CANLF adenosine deaminase (EC 3.5.4.4) ADA2 Canis lupus familiaris (Dog) (Canis familiaris) adenosine catabolic process [GO:0006154] extracellular space [GO:0005615] adenosine deaminase activity [GO:0004000]; metal ion binding [GO:0046872] EFDNRLLKNFTLMTEN;VISSDDPAIFGAKGLSYD 2 6.6 0.99195 -0.20884 8.4722 0 0 9.28362 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S7S4 A0A8I3S7S4_CANLF Potassium voltage-gated channel subfamily H member 5 KCNH5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of membrane potential [GO:0042391] cell surface [GO:0009986]; monoatomic ion channel complex [GO:0034702] calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249] FVVSGSLEVI;GEARSPLEHSPIQ;QEAPKTPPHIILHYCA;TLSIPVDHPVRKLFQKFKQQ;VLSICPKDMRADICVHLNRK 5 8 0.99622 -0.095815 8.98647 0 9.3107 0 7.10024 0 0 0 0 0 0 0 0 5.54065 10.5482 A0A8I3S7T3 A0A8I3S7T3_CANLF Dihydropyrimidinase like 4 DPYSL4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "filamin binding [GO:0031005]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" GVDVHTRLQMPVL;VTSPPVSPDPSTAD 2 4.7 0.98665 -0.40958 0 0 0 0 0 0 0 0 0 0 0 10.1929 10.7106 0 0 A0A8I3S7U5 A0A8I3S7U5_CANLF Sulfide quinone oxidoreductase SQOR Canis lupus familiaris (Dog) (Canis familiaris) "sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]" glutathione-dependent sulfide quinone oxidoreductase activity [GO:0106436]; sulfide:quinone oxidoreductase activity [GO:0070224] PLETFPFDQSRERLTMYLMKA;RLTMYLMKADLMPFLY;VEPSERHF;VGADNVAVVEPSERHFYQ 4 10.2 1.0021 -1.2924 0 0 8.45947 0 8.77334 0 0 0 0 0 0 9.1289 0 0 0 A0A8I3S7W4 A0A8I3S7W4_CANLF Argonaute RISC catalytic component 3 AGO4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] P-body [GO:0000932]; RISC complex [GO:0016442] miRNA binding [GO:0035198]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] EACISLEKDYQPGIT;FPLQLENGQTVERTVAQ;GADVTHPPAG;IIEFMCEVLDI;TVRVQRPRQEIIQDLASMV;VGSMDAHPSRYCATVRV;VSLQLLLEALAGHLNEVPD;YRAQPIIEFM 8 12.8 1.0018 -1.2685 0 7.45261 0 10.615 0 0 6.99266 10.3665 7.72567 0 0 0 0 0 4.54405 A0A8I3S7W7 A0A8I3S7W7_CANLF ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531] centrosome [GO:0005813]; cilium [GO:0005929]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] QDVVMDAEFQVLLR 1 15.4 0.93737 0.060957 0 0 0 0 0 9.31238 0 0 0 0 0 0 0 0 0 A0A8I3S7X4 A0A8I3S7X4_CANLF Triacylglycerol lipase (EC 3.1.1.3) (Pancreatic lipase) PNLIPRP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] extracellular region [GO:0005576] metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806] CFSDAEPWA;EEVRLDPTDADFVDVIHTDA;LKVLPWSPERI;TVQKGEEKTVYVY;VGRDWCLYWQLTPGK 5 13.8 1.0032 -1.0564 0 7.04767 0 0 6.51753 0 0 3.99059 0 0 0 0 0 0 9.28161 A0A8I3S7X7 A0A8I3S7X7_CANLF Transcription factor binding to IGHM enhancer 3 TFE3 Canis lupus familiaris (Dog) (Canis familiaris) humoral immune response [GO:0006959]; lysosome organization [GO:0007040]; positive regulation of cell adhesion [GO:0045785]; regulation of osteoclast differentiation [GO:0045670] cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654] "DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" APEAAHATGPTGSA;LSSVSPAVSKAS;QQRSKDLESRQRSLEQT;RQRSLEQTNRSL 4 8.2 0.98624 -0.39229 0 0 10.6929 0 0 0 0 0 0 0 7.64198 8.93614 7.55566 0 0 A0A8I3S7Y1 A0A8I3S7Y1_CANLF Shootin-1 SHTN1 Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175] DTENSETELERI 1 2.2 0.984 -0.24456 0 0 0 12.594 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S7Y7 A0A8I3S7Y7_CANLF Ubiquitin specific peptidase 40 USP40 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] DYSTVSDF;FLRAWTVERKRLGRLLRI;GPALPCAQARFSC;IHVRSFRKHE;LWNMYVEEEVFDCDNLYH;NVLLEDDGDFST;NWQFQEEKSKPGMNL;NWQFQEEKSKPGMNLKDLQNEEE;PISSWNQQF 9 7.8 1.0033 -2.0807 0 0 6.25219 14.8869 14.8727 0 8.53559 13.8644 0 5.945 0 0 0 9.56236 0 A0A8I3S7Z6 A0A8I3S7Z6_CANLF Zinc finger protein 770 ZNF770 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] IVKKILAKLKRA;PCDKCEKVFPSISKLQ;SEDFILSTPYRNRQ;TEIKVKVESEDFILS;TGELSPEQT 5 9.1 0.99168 -0.54264 0 0 7.02148 0 10.424 8.91874 0 0 0 0 0 0 4.81517 0 0 A0A8I3S829 A0A8I3S829_CANLF MORN repeat-containing protein 3 MORN3 Canis lupus familiaris (Dog) (Canis familiaris) acrosomal vesicle [GO:0001669] EMGKHRKVYSGWWKG;QEMGKHRKVYSGWWKG 2 6.7 0.98941 -0.19736 0 0 9.71443 0 0 0 0 0 0 0 4.43283 0 0 0 0 A0A8I3S850 A0A8I3S850_CANLF Keratin 77 KRT77 Canis lupus familiaris (Dog) (Canis familiaris) cornified envelope [GO:0001533]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] AGGKFGGG;DVKNMQDVVEDYKSKYEEEINRR;ENVPVPQPKPRQ;GGGGGGGG;IAQKSKDEAEAL 5 12.3 1.0017 -1.4124 10.1252 0 0 0 0 5.35724 0 0 8.45599 9.98428 11.1218 0 0 10.4405 10.346 A0A8I3S869 A0A8I3S869_CANLF Ring finger protein 39 RNF39 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] SSGEDEADE 1 2.6 1.0035 -0.80421 4.72917 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S8A6 A0A8I3S8A6_CANLF Keratin 73 KRT73 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EFVVLKKD;ESVKKQCSNLET 2 3.7 0.98492 -0.24608 0 0 0 0 0 0 9.74121 0 0 0 0 0 0 0 0 A0A8I3S8H8 A0A8I3S8H8_CANLF Protein FAM32A Canis lupus familiaris (Dog) (Canis familiaris) FEKSQEKWQMERILKKAP 1 16.4 0.97213 0.048313 0 0 7.01502 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S8N4 A0A8I3S8N4_CANLF Leukocyte surface antigen CD47 (Integrin-associated protein) CD47 Canis lupus familiaris (Dog) (Canis familiaris) ATP export [GO:1904669]; cellular response to interleukin-12 [GO:0071349]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of phagocytosis [GO:0050766]; positive regulation of T cell activation [GO:0050870]; regulation of interleukin-10 production [GO:0032653]; regulation of interleukin-12 production [GO:0032655]; regulation of interleukin-6 production [GO:0032675]; regulation of tumor necrosis factor production [GO:0032680]; regulation of type II interferon production [GO:0032649] cell surface [GO:0009986]; plasma membrane [GO:0005886] cell-cell adhesion mediator activity [GO:0098632]; thrombospondin receptor activity [GO:0070053] SSAQLIFNITKSV 1 4.1 0.99066 -0.27514 11.0918 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S8S2 A0A8I3S8S2_CANLF Olfactory receptor LOC119868906 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LEIGYTCSVIPK;TLILLMFLASL 2 7.2 0.99159 -0.27707 0 0 0 0 0 5.6682 0 0 0 0 0 0 0 0 0 A0A8I3S8T5 A0A8I3S8T5_CANLF C-type lectin domain-containing protein LOC119868927 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] carbohydrate binding [GO:0030246] INFNDIQELC;LPASLDEELQTTLHDL;SGDFQYMDGAPVN;TEEQGRKVEGEARQV 4 21.2 0.95125 0.053889 0 0 0 0 0 0 0 6.61924 0 0 0 0 0 0 0 A0A8I3S8V0 A0A8I3S8V0_CANLF CCN family member 1 (Cellular communication network factor 1) (Protein CYR61) CCN1 Canis lupus familiaris (Dog) (Canis familiaris) "positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of ERK1 and ERK2 cascade [GO:0070372]; signal transduction [GO:0007165]; wound healing, spreading of cells [GO:0044319]" extracellular region [GO:0005576] growth factor binding [GO:0019838] ACHCPQEAPKCAPGVGLVRDGC;GQCCEEWVCDDD;MRFRCEDGETFSKNVM 3 13.1 0.99182 -0.1942 0 0 0 0 0 0 0 6.69488 2.62199 0 0 0 0 0 0 A0A8I3S8V5 A0A8I3S8V5_CANLF adenylate cyclase (EC 4.6.1.1) ADCY6 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] DEAFIRRGGP;GSREVRPS;PEYFVGNMLLS;SSLTLLMAVLVLLTAVLLAFHAAPA 4 4.8 1.0017 -1.2132 0 6.11794 0 0 6.18704 0 0 0 0 0 0 8.2212 0 0 9.35924 A0A8I3S8V7 A0A8I3S8V7_CANLF HSPB1 associated protein 1 HSPBAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DLLLGTIKQEA;MGMKRTDTVPQ;QRFPQFCKARRYMVTL;TDIFQDVI 4 10.2 1.0023 -0.95825 0 0 0 0 0 0 0 8.27221 0 0 0 0 8.10397 0 0 A0A8I3S8X1 A0A8I3S8X1_CANLF Small ribosomal subunit protein eS6 (40S ribosomal protein S6) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LIHEWAGLG;PKIQRLVTPRVLQHKRRRIAL;RLVTPRVLQHKRRRIALKKQ;VTPRVLQHKRRRIALKKQRTKK 4 22.4 0.99409 -0.12897 0 0 0 3.61023 6.27611 0 0 0 0 0 0 0 0 5.87509 0 A0A8I3S8X7 A0A8I3S8X7_CANLF Cilia and flagella associated protein 46 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] EFDPTESFSPDLFVL;LSVTYDINVL 2 8.7 0.98342 -0.25542 0 0 0 0 0 6.00881 0 0 0 0 0 0 0 0 0 A0A8I3S8Z0 A0A8I3S8Z0_CANLF Ubiquitin like modifier activating enzyme 7 UBA7 Canis lupus familiaris (Dog) (Canis familiaris) GVGRHGLNRA;LAVNHYELQLRF 2 11.2 0.99949 -0.61146 0 0 0 0 8.12892 0 0 0 0 0 0 0 0 0 0 A0A8I3S912 A0A8I3S912_CANLF FAM21/CAPZIP domain-containing protein WASHC2C Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; nucleus [GO:0005634]; plasma membrane [GO:0005886] DDDDDDDDDFF;DEDDSEDNLFG;DEDEESDLFT;EDDDGCDIFADSEKEE;EEEDDDGC;FDDDDDDDDDDF;GAVSLFLGDT;GVFQDEELLFSHK;PAKSQPLISEKKRLVK;PTAQMSDEEEDDD;VEGAVESSEL 11 8.3 1.0028 -1.8908 10.8132 6.40858 0 0 0 5.298 12.1066 0 0 0 0 0 8.20892 9.5005 10.3416 A0A8I3S980 A0A8I3S980_CANLF Myomesin 2 MYOM2 Canis lupus familiaris (Dog) (Canis familiaris) AGISRPSRVSEAVAALDPVDLR;GSNAWEPCNHKPIGY;GVGRPSETS;LDLSGQERSMR;LFKCEAWTM;LKSELAYEIFD;RVLSANKHGLS 7 6.1 0.97862 0.035491 0 0 0 0 0 6.93852 0 0 0 0 0 0 0 0 0 A0A8I3S9A6 A0A8I3S9A6_CANLF Mab-21 domain containing 2 MB21D2 Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex binding [GO:0044877] FKGWPAVAQSWLMENHFWDGKITE;QLVTENPG;RKLSSVRSDP 3 8.6 1.003 -1.7127 0 0 0 0 0 0 12.6366 0 0 0 0 6.94404 0 7.79643 0 A0A8I3S9D3 A0A8I3S9D3_CANLF BMP binding endothelial regulator BMPER Canis lupus familiaris (Dog) (Canis familiaris) FLYDNCTACTCQ 1 2.3 0.94516 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 5.98493 0 0 A0A8I3S9F2 A0A8I3S9F2_CANLF Uncharacterized protein TNFRSF13B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] GASPPEPVETCSFCF;GRRGLLGL 2 8 1.0048 -1.0505 0 0 0 0 0 0 0 0 0 0 9.15353 0 0 0 0 A0A8I3S9G9 A0A8I3S9G9_CANLF Golgin A3 GOLGA3 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] ASAAPLGDHANPRGDTEQHS;MVEAYRRDATS;SIEASLPLEKEEL;VEHSHNSQQ;VGPDASPGVAGFHD 5 4.5 1.0011 -0.63761 11.1351 0 7.91241 7.44758 0 7.78431 9.70889 0 0 9.38821 4.99191 0 7.70757 7.52442 7.76573 A0A8I3S9H2 A0A8I3S9H2_CANLF Platelet glycoprotein 4 (Glycoprotein IIIb) (PAS IV) (PAS-4) (Platelet glycoprotein IV) CD36 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; lipid transport [GO:0006869] apical plasma membrane [GO:0016324]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121] GLSPNEDEHTTYLDVEPIT;RLQINILVKPAKKIEAL;TVKELLWGY 3 10.4 0.98738 -0.37099 0 0 5.62559 0 0 9.53401 0 0 0 0 9.36628 0 0 11.3947 0 A0A8I3S9H6 A0A8I3S9H6_CANLF Peroxisomal biogenesis factor 11 gamma PEX11G Canis lupus familiaris (Dog) (Canis familiaris) peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375] peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991] CVDSARWWTLSTAFW;EDSFVRCVSVLGNVADQLYYPC;FIYTKQYGLGPE;GLLGTVSSLLSV;LSLLLGIARSLWLVLTLRRRL;LSLLLGIARSLWLVLTLRRRLRSPV 6 35.7 0.69474 0.28616 5.95205 5.91855 8.32576 0 9.03006 0 0 9.40399 0 0 8.64368 5.81987 0 9.60576 0 A0A8I3S9I2 A0A8I3S9I2_CANLF Uncharacterized protein LOC492221 Canis lupus familiaris (Dog) (Canis familiaris) ITPAFQDDFLI;VGSNPPEEQEDE 2 6.4 0.98691 -0.23453 0 0 0 0 0 0 0 0 0 0 0 0 11.386 0 0 A0A8I3S9K1 A0A8I3S9K1_CANLF Grainyhead like transcription factor 1 GRHL1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DKGAERKIRDEERKQS;GEPPRAATAAP;SEELEGEGSNLKRG 3 4.4 0.99106 -0.18572 0 0 0 0 8.05496 7.81359 0 0 0 0 0 7.37321 0 0 0 A0A8I3S9L5 A0A8I3S9L5_CANLF Gamma-aminobutyric acid type A receptor subunit alpha3 GABRA3 Canis lupus familiaris (Dog) (Canis familiaris) chloride transport [GO:0006821]; gamma-aminobutyric acid signaling pathway [GO:0007214] membrane [GO:0016020] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] STLLLGLRFWLC 1 3.7 0.94555 0.05044 5.1758 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S9N5 A0A8I3S9N5_CANLF GLIPR1 like 2 GLIPR1L2 Canis lupus familiaris (Dog) (Canis familiaris) QEVKEEDKEKKKEEVKEEEGDKEEE;SWYEERKKYHFEN 2 10.3 0.92329 0.095099 10.3939 0 0 0 0 0 0 0 0 0 0 0 0 4.26416 0 A0A8I3S9N7 A0A8I3S9N7_CANLF Ankyrin repeat and LEM domain containing 2 ANKLE2 Canis lupus familiaris (Dog) (Canis familiaris) central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; positive regulation of protein dephosphorylation [GO:0035307] endoplasmic reticulum membrane [GO:0005789] protein phosphatase 2A binding [GO:0051721] EEPSKLDRDVLAALEYANVDPQQYP;LSPSKAEDF;SSHPLIVKNP 3 4.9 1.0023 -1.152 0 0 0 8.39227 8.73332 9.48267 12.8641 0 0 0 0 8.81105 0 7.47679 0 A0A8I3S9Q1 A0A8I3S9Q1_CANLF Uncharacterized protein WWC3 Canis lupus familiaris (Dog) (Canis familiaris) DIIGEFVFD;LRWYTVQVFGSCGPPR;VYLPPIDSG;YMDHINKLTQLEDPREQWRREQER 4 4.8 0.98622 -0.38882 4.7 0 0 0 8.97782 0 0 0 0 7.10192 0 0 0 9.61486 0 A0A8I3S9Q5 A0A8I3S9Q5_CANLF Olfactory receptor OR8S7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSADPKVQALLFVL 1 4.5 0.944 0.06115 0 0 7.58856 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S9R6 A0A8I3S9R6_CANLF Minichromosome maintenance complex component 3 associated protein MCM3AP Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] EDVYWLSALLQLKQLLQA;EVSKERERKEEERRQAE;GTSVSERLKHLE;LTELVVTECVRETCSQ;LVVTECVRETCSQEL;VDHAAAVKEYSRS 6 4 0.99548 -0.56906 10.0459 0 0 13.7626 9.93016 0 0 0 0 0 0 0 0 0 0 A0A8I3S9S8 A0A8I3S9S8_CANLF "Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5) (Serine/threonine-protein phosphatase Pgam5, mitochondrial)" PXMP2 Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] mitochondrial outer membrane [GO:0005741] AGGDAEPRVVEAPAWAGTARPGPG 1 8.3 0.97152 0.041303 0 0 0 9.1575 0 0 0 0 0 0 0 0 0 0 0 A0A8I3S9V0 A0A8I3S9V0_CANLF THAP domain containing 3 THAP3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] DNA binding [GO:0003677] LDALKKKLFLTL 1 5.4 0.94982 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 3.79338 0 0 A0A8I3S9W4 A0A8I3S9W4_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) SYVN1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; transferase activity [GO:0016740] LDFLFVSH;LTGAVVAH;MYLAMRQFKKAV;TQSPPPPEPADQGPPA 4 6.6 1.0014 -0.9409 0 6.07208 0 0 0 0 0 0 8.25328 0 0 0 0 0 8.852 A0A8I3S9Y6 A0A8I3S9Y6_CANLF C-terminal binding protein 2 CTBP2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to leukemia inhibitory factor [GO:1990830]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription by RNA polymerase II [GO:0045944]; synaptic vesicle docking [GO:0016081]; white fat cell differentiation [GO:0050872] GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; photoreceptor ribbon synapse [GO:0098684]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic cytosol [GO:0099523]; transcription repressor complex [GO:0017053] "chromatin binding [GO:0003682]; NAD binding [GO:0051287]; nuclear retinoic acid receptor binding [GO:0042974]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; structural constituent of presynaptic active zone [GO:0098882]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]" DVGERPGESGPARQAA;GVQRVYTLQDLLY 2 3 0.9878 -0.48599 0 0 0 0 0 0 0 10.2142 0 0 0 0 0 9.06805 0 A0A8I3SA04 A0A8I3SA04_CANLF Ankyrin repeat domain 26 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KVHINFFFFFFYK 1 6.2 0.98917 -0.26055 0 0 0 0 0 0 0 0 0 0 0 0 10.1633 0 0 A0A8I3SA30 A0A8I3SA30_CANLF Arachidonate 5-lipoxygenase ALOX5 Canis lupus familiaris (Dog) (Canis familiaris) dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426] cytosol [GO:0005829]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471] arachidonate 5-lipoxygenase activity [GO:0004051]; iron ion binding [GO:0005506] DIQLVKIEKRKYWL;KAREQLICEYGLFDKANA;NLDTIVSMIAERNKN;PNAPPTMR;QVPGDENP 5 9.3 1.0026 -1.745 0 0 9.90573 5.38457 0 8.59122 0 0 0 0 0 7.98931 0 0 0 A0A8I3SA39 A0A8I3SA39_CANLF Uncharacterized protein AKAP4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; establishment of localization in cell [GO:0051649]; establishment of protein localization [GO:0045184]; sperm flagellum assembly [GO:0120316] perinuclear region of cytoplasm [GO:0048471]; sperm end piece [GO:0097229]; sperm fibrous sheath [GO:0035686]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; Z disc [GO:0030018] protein kinase A binding [GO:0051018] ACEEDCPGSTTGYMTQSAQYE;FVDVSTLNVEDKDSKDAA;GVLMTDSDFVS;IDSCLKNLHNITGVLMTD;SIYPSPGDKGKNSP;SLTSAEKVGEHILKESLTM;YSPTGQQDQ 7 12.1 1.0027 -0.87861 0 9.71089 5.23875 0 0 0 0 0 5.80601 0 0 0 9.38429 9.03661 0 A0A8I3SA67 A0A8I3SA67_CANLF DNA helicase (EC 3.6.4.12) CHD3 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spindle organization [GO:0007051] centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; NuRD complex [GO:0016581]; PML body [GO:0016605] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976] ADVTRLPA;DEDYEEDDDE;DGVPREGLS;EAADEDYEEDDDEGVLG;EEYEEGEEEGEKEEEDDHMEYCRV;EPAHPAMALH;FSFEDNAIKGGK;GVKKRKRGPKKQ;LSYWHCSWAKE;NSPCTSKPA;QWEAKEEEEEYE;RKHREKKEKKTKRRKK;SADSKRSSRASSPTKTSPTTPEA;SEEEFGSE;VSVPAPQQADGNP 15 8.8 1.002 -1.4715 7.28873 4.52362 10.7339 10.7182 9.69223 9.85223 9.13668 0 10.0566 0 4.75622 0 7.40114 13.9453 8.50922 A0A8I3SA78 A0A8I3SA78_CANLF Solute carrier family 9 member B1 SLC9B1 Canis lupus familiaris (Dog) (Canis familiaris) proton transmembrane transport [GO:1902600] membrane [GO:0016020] antiporter activity [GO:0015297] GALIIGILGPKIL;KEKIFIALSWMPKATVQA;LAMGPCLMEACS;PQMEKKYSCPP 4 10.5 0.98638 -0.4513 0 0 0 3.28907 0 0 0 10.9237 0 0 0 0 0 0 0 A0A8I3SAD1 A0A8I3SAD1_CANLF Transmembrane protein 72 TMEM72 Canis lupus familiaris (Dog) (Canis familiaris) TELTLEPADSLVKKK;VGTETFLQGQ 2 9.1 0.98421 -0.25441 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.77494 A0A8I3SAH2 A0A8I3SAH2_CANLF Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) Canis lupus familiaris (Dog) (Canis familiaris) translational elongation [GO:0006414] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] EESEESDDDM;ICNVGAGG;TAAGAAPM;VGAGGFTT 4 24.6 0.99908 -3.0699 0 0 10.7113 9.1694 0 8.67412 0 9.25056 0 10.8227 0 0 11.1208 7.48583 0 A0A8I3SAH6 A0A8I3SAH6_CANLF SH3 domain-binding protein 5 (SH3BP-5) SH3BP5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasmic vesicle membrane [GO:0030659]; nuclear body [GO:0016604] guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]; SH3 domain binding [GO:0017124] EDDSETQS;ENRMKQLSLQCSKG;RDQALVSDFKQQKLEKE 3 8.1 0.98202 0.046227 0 0 0 0 10.8918 0 0 0 0 0 0 0 0 0 0 A0A8I3SAJ2 A0A8I3SAJ2_CANLF U2AF homology motif kinase 1 UHMK1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of translational initiation [GO:0045948]; regulation of protein export from nucleus [GO:0046825] neuronal ribonucleoprotein granule [GO:0071598]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; ribonucleoprotein complex binding [GO:0043021] AEMALCSPFFS 1 3.2 0.9846 0.035491 0 0 0 10.5736 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SAJ5 A0A8I3SAJ5_CANLF Periostin POSTN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] cell adhesion molecule binding [GO:0050839] AGNQQTTFTDLVAQ;EETLKKLL;GDTPVKKI;IMGDKVASEALM;PMTVYKPIIKKYTKII 5 7.4 0.96254 0.049233 0 0 0 0 4.83966 0 0 0 0 3.68111 0 0 4.61247 0 0 A0A8I3SAJ6 A0A8I3SAJ6_CANLF Phosphodiesterase (EC 3.1.4.-) PDE4A Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; cellular response to xenobiotic stimulus [GO:0071466]; regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106070]; regulation of protein kinase A signaling [GO:0010738]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] "3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; cAMP binding [GO:0030552]; metal ion binding [GO:0046872]" APSERSLSLSL;DHPGVSNQFL;DLLKKFRIP;LPALRTLPP;TDRIMAEFFQQGDRER 5 6.3 0.9816 0.035491 0 0 0 0 0 0 0 0 0 0 0 8.11894 0 0 0 A0A8I3SAL7 A0A8I3SAL7_CANLF ETS transcription factor ELK4 ELK4 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]" AEGDCEALSCGEVGG;ARASSRNDY;LSPSLPTASLT;TDIDSVASQP 4 11.2 1.0021 -0.67188 0 0 10.1938 10.5818 5.72326 0 0 0 0 0 0 0 0 0 0 A0A8I3SAN2 A0A8I3SAN2_CANLF Cadherin related family member 3 CDHR3 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] FEVVTTGKEELD;GSILLLGLLVSLLVLLAKTIHRRC;LTLGSILLLGLLVSLLVLLAKTI;PQTGELQLVTRADYETTPVYIL;TTPSGVGSGGRFSQDP 5 8.7 0.98651 -0.32113 9.25276 6.04474 0 0 0 0 0 0 10.5055 0 0 0 0 0 7.44774 A0A8I3SAN7 A0A8I3SAN7_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) CTDSP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] ERGSGRRGP;RSGRGEGGGGGAGRWLRDTGRGP 2 9.9 0.99062 -0.51198 0 0 0 0 0 0 0 0 0 0 9.75394 10.1022 0 0 0 A0A8I3SAP2 A0A8I3SAP2_CANLF Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) MAOA Canis lupus familiaris (Dog) (Canis familiaris) catecholamine metabolic process [GO:0006584] mitochondrial outer membrane [GO:0005741] flavin adenine dinucleotide binding [GO:0050660]; primary amine oxidase activity [GO:0008131] GASGKGSI;VLNALGRV 2 1.7 1.0021 -1.3703 0 0 0 0 0 0 0 8.37099 11.161 0 0 0 6.78895 0 0 A0A8I3SAS5 A0A8I3SAS5_CANLF Regulator of G protein signaling 22 RGS22 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] G-protein alpha-subunit binding [GO:0001965] DLFDTAEEYILLLLL;FRRIIYGD;RHFNFNDLLNN;SHFEEEEDGSVSVQDTPSQ;SWITVVVLADNIP 5 5.4 1.0028 -1.4917 0 6.77479 0 0 0 0 5.48787 8.58451 0 0 0 0 9.6239 0 0 A0A8I3SAY7 A0A8I3SAY7_CANLF RAD52 motif-containing protein 1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] cytoplasm [GO:0005737]; nucleolus [GO:0005730] RNA binding [GO:0003723] EVELETRAE;GPASLEEARGH;RPGFCAIIKFYSAR;VHLGTKHKAVQH 4 13.2 0.93726 0.062897 0 0 4.94944 0 6.71768 13.0836 0 0 0 0 0 9.34172 0 0 0 A0A8I3SB07 A0A8I3SB07_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) VKIPALSTVLELP 1 12.3 0.93739 0.059581 0 0 0 0 0 0 0 3.50944 0 0 0 0 0 0 0 A0A8I3SB09 A0A8I3SB09_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] GAEKVDPRFEG 1 5.9 0.98752 0.035491 9.86822 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SB10 A0A8I3SB10_CANLF SplA/ryanodine receptor domain and SOCS box containing 4 SPSB4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; positive regulation of protein polyubiquitination [GO:1902916]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829] ubiquitin-like ligase-substrate adaptor activity [GO:1990756] DIGALPLPQSL;LDQLLDMPAAG;LDQLLDMPAAGLAVQ 3 9.5 0.99212 -0.14864 0 0 0 0 0 0 9.40716 0 0 0 10.6462 0 0 10.353 10.45 A0A8I3SB35 A0A8I3SB35_CANLF Cathepsin E (EC 3.4.23.34) CTSE Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; proteolysis [GO:0006508] endosome [GO:0005768] aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802] GNLNWVPVTKQGYWQ;LINYLDME;MPDVTFIINGVSYTL 3 9.6 1.0018 -1.2886 0 0 0 0 0 0 10.5707 8.93993 0 0 0 0 0 0 0 A0A8I3SB57 A0A8I3SB57_CANLF Ig-like domain-containing protein CD276 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cytokine production [GO:0001817]; T cell receptor signaling pathway [GO:0050852] external side of plasma membrane [GO:0009897] signaling receptor binding [GO:0005102] AALWFCITGAVE;GANGTYSC;GAVEVQVPEDP;KPSMTLEPSK;LLRGQWGMGPSRTPP;MGSSRAGRGP;SRAGGGGA;SVTITGQPMTFPP 8 11.5 1.0035 -2.225 13.3851 0 12.2907 9.47883 0 0 0 2.8585 8.04816 7.01981 0 10.8225 3.42921 0 8.92547 A0A8I3SB92 A0A8I3SB92_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] CTGSWAQSVLTQPASVSGS;EADYYCSTYDSHY;LQAEDEADYYCSTYDS;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 29.6 0.93781 0.059735 0 5.8746 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SB93 A0A8I3SB93_CANLF SH3 and PX domains 2A SH3PXD2A Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EVIDKNSGG;FWWPCPTCWCCH;KRRKAHLRRLDR;SIADYEGDEETAGF 4 4.9 0.95342 0.05044 0 0 0 0 0 0 4.77695 0 0 0 0 0 0 0 0 A0A8I3SB94 A0A8I3SB94_CANLF ATPase H+ transporting V0 subunit b ATP6V0B Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; endosome [GO:0005768]; proton-transporting V-type ATPase, V0 domain [GO:0033179]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" VFVAFWACMVVVGICYTIFDLG 1 10.7 0.98845 -0.26102 0 10.9289 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SBB2 A0A8I3SBB2_CANLF Suppressor of cytokine signaling 5 SOCS5 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular signal transduction [GO:0035556]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; vascular endothelial cell response to fluid shear stress [GO:0097699] phosphatidylinositol 3-kinase complex [GO:0005942] 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; epidermal growth factor receptor binding [GO:0005154]; receptor tyrosine kinase binding [GO:0030971] KEYHYKQKVRV;LVSTEDEEDRLRERRRLSIEEG;TISLNRTFPFSLQ;VGKMWNHFK;VGKMWNHFKYRCQN 5 11.2 1.0027 -1.0096 0 0 0 9.85036 0 0 7.61066 12.7745 9.30873 0 0 0 0 0 0 A0A8I3SBB6 A0A8I3SBB6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] GAATLGVA 1 7.3 1.0043 -1.1044 0 0 0 0 0 0 0 0 11.0477 0 0 0 0 0 0 A0A8I3SBD0 A0A8I3SBD0_CANLF BLOC-1 related complex subunit 6 BORCS6 Canis lupus familiaris (Dog) (Canis familiaris) lysosome localization [GO:0032418] BORC complex [GO:0099078] identical protein binding [GO:0042802] GGGGGGGA;TVSRHGDLTHFVANNLQ;TYRDAVDSL 3 9.7 0.93679 0.10434 0 12.9172 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SBF3 A0A8I3SBF3_CANLF Cytochrome P450 family 27 subfamily A member 1 CYP27A1 Canis lupus familiaris (Dog) (Canis familiaris) calcitriol biosynthetic process from calciol [GO:0036378] endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LRGARGAL 1 1.6 0.98712 -0.23099 0 0 0 0 0 0 0 8.06776 7.83731 0 0 0 0 0 0 A0A8I3SBH7 A0A8I3SBH7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) SLLTQPASVSG;TESVKGKRQFCPR 2 17.5 0.99225 0.0062972 0 0 7.38319 9.18562 9.51605 0 0 0 7.95175 0 0 0 0 0 0 A0A8I3SBH9 A0A8I3SBH9_CANLF Potassium channel tetramerization domain containing 18 KCTD18 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] EAGNNVQYIW;HIPTDEQTRIALQEEADYFGIPYP;WEGKGVSYWRVPHE 3 12.3 1.0034 -0.83672 0 0 0 0 0 0 0 0 0 0 9.49777 6.75475 0 9.60145 0 A0A8I3SBJ2 A0A8I3SBJ2_CANLF Axin 2 AXIN2 Canis lupus familiaris (Dog) (Canis familiaris) cell development [GO:0048468]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of centromeric sister chromatid cohesion [GO:0070602]; Wnt signaling pathway [GO:0016055] beta-catenin destruction complex [GO:0030877]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] beta-catenin binding [GO:0008013]; I-SMAD binding [GO:0070411]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625] AEVSKPPKQR;EQLSKKGNYRYY;FKEQLSKKGNYRYY;KALEPVQAEQFS;PGCQSPGVGRYSPRSRSP;RVLKTPGCQSPGVGR;SPGVGRYSPRSRSPD;VDTLDFWFACNG 8 9.3 1.0028 -0.77319 0 9.27968 10.0884 4.5435 3.51803 11.5556 0 0 0 0 10.1674 0 0 0 0 A0A8I3SBJ6 A0A8I3SBJ6_CANLF Lysophosphatidic acid receptor 5 LPAR5 Canis lupus familiaris (Dog) (Canis familiaris) behavioral response to pain [GO:0048266] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AAIVHPLRLRH;AIVHPLRLRHLRRP 2 4.1 0.99105 -0.20561 0 0 0 0 0 0 0 0 0 8.41857 0 0 0 6.24016 0 A0A8I3SBN0 A0A8I3SBN0_CANLF Occludin/ELL domain containing 1 OCEL1 Canis lupus familiaris (Dog) (Canis familiaris) AGCCASQSGACMQM;IEAIPREHTPRPQ;RPPVLPRPRPP 3 12.5 0.99349 -0.55696 0 0 0 0 0 0 0 7.77406 0 0 0 0 0 0 0 A0A8I3SBN8 A0A8I3SBN8_CANLF Asteroid homolog 1 ASTE1 Canis lupus familiaris (Dog) (Canis familiaris) nuclease activity [GO:0004518] LSLAKRQILLLETLKVKQTILE 1 3.4 0.97424 0.046699 0 0 7.35975 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SBR3 A0A8I3SBR3_CANLF Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase H6PD Canis lupus familiaris (Dog) (Canis familiaris) glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098] 6-phosphogluconolactonase activity [GO:0017057]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661] DIARSINSSCRPGPGAWL;LVTNSSFDLVL;RHHVERVEI 3 4.8 1.0026 -0.72041 0 0 0 12.9803 7.72458 0 14.6541 0 0 0 0 0 10.4881 0 0 A0A8I3SBU7 A0A8I3SBU7_CANLF Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial matrix [GO:0030150] fibrillar center [GO:0001650]; mitochondrial matrix [GO:0005759]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744] protein-folding chaperone binding [GO:0051087] ESETVRTSEVIK 1 2.6 0.95198 0.05044 0 0 0 0 0 0 0 0 0 0 0 8.83823 0 0 0 A0A8I3SBX3 A0A8I3SBX3_CANLF Rab GDP dissociation inhibitor GDI1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093] KRMAGSAFDFENMKRKQNDVF;NSCQIIIPQ;QNQVNRKSDIYVCMISY;YGGESSSI 4 12.2 0.97849 0.047674 0 0 0 0 6.02642 0 0 0 0 0 0 0 0 0 0 A0A8I3SBZ9 A0A8I3SBZ9_CANLF Acyltransferase (EC 2.3.1.-) DGAT2L6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] VPSYSFGE 1 2.4 0.98245 -0.25102 7.5941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SC46 A0A8I3SC46_CANLF PDZ domain-containing protein 11 PDZD11 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361] basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; presynapse [GO:0098793] VLFHLFSSFSLSIS 1 3.7 0.93969 0.064209 0 0 0 0 0 0 8.93931 0 0 0 0 0 0 0 0 A0A8I3SC55 A0A8I3SC55_CANLF Villin like VILL Canis lupus familiaris (Dog) (Canis familiaris) actin filament capping [GO:0051693]; cytoskeleton organization [GO:0007010] actin filament binding [GO:0051015] QEDLDKYDIMLLDT;TNNQSYEEVVDGGLGA;YLSDSDFQDIFGKSKEEFYSMAKWR 3 6.4 0.99081 -0.21087 0 7.48519 0 0 0 0 0 0 0 0 0 0 0 0 3.909 A0A8I3SC91 A0A8I3SC91_CANLF BICD family like cargo adaptor 1 BICDL1 Canis lupus familiaris (Dog) (Canis familiaris) AEGSELQPPPAQD;DMHRVIDRQLMDTHLKE;LQEVRLSYR;VHLREADRE;VHLREADREKTR;VLAARLGK 6 10.3 1.0027 -2.1206 8.98854 10.3107 10.2215 0 0 0 10.4193 0 8.56662 0 14.1744 0 0 0 0 A0A8I3SC96 A0A8I3SC96_CANLF Single Ig and TIR domain containing SIGIRR Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ILKPQLERRRGYKLFLD;VLASLLVLLALLLAALLYVK 2 9 0.93171 0.094433 0 0 0 0 0 0 7.31524 0 0 0 0 0 0 0 0 A0A8I3SCA7 A0A8I3SCA7_CANLF Acyl-CoA dehydrogenase family member 11 ACAD11 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] mitochondrial membrane [GO:0031966]; nucleus [GO:0005634] flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099] GEGRGFEIAQGRLGPGRI;MAAEASPEPDTAEV;QYQAAAHQDVPAMNQLSDWLMKNLP 3 7.3 0.99161 -0.1371 0 9.39904 0 0 0 0 8.55674 0 9.56946 0 0 0 0 0 0 A0A8I3SCB1 A0A8I3SCB1_CANLF Integrin beta ITGB6 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] focal adhesion [GO:0005925]; plasma membrane [GO:0005886] CDCGECVCRPGWAG;DNGVCDCGECVCRPG;GVCACNPGHMGPRCEC;IECHLSADGQARE;IIHSINEKDCPKPPNI;QTLQVQVRQTEDY;RCPTCGDPC;SPECNCDCQ;TSTDSCGSEDGVLCS;VLCSGRGD 10 16.3 1.0021 -1.4231 0 0 8.36396 12.5467 0 6.55902 9.49781 11.9469 11.2957 0 0 0 5.16985 6.518 0 A0A8I3SCC3 A0A8I3SCC3_CANLF Ankyrin repeat and SOCS box containing 11 ASB11 Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506] phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176] TFYTWRNVAERTEKVYDHVA;THQYPYSKKRGE 2 12.8 0.98376 -0.24453 0 0 0 0 0 0 0 9.99166 9.55741 0 0 0 0 0 0 A0A8I3SCC5 A0A8I3SCC5_CANLF Synaptic plasticity regulator PANTS (Plasticity-associated neural transcript short) C26H22orf39 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of long-term synaptic potentiation [GO:1900272] synapse [GO:0045202]; synaptic cleft [GO:0043083] CREWEERRSAEAQRSLCESERA 1 20.8 0.97549 0.046883 0 0 0 0 9.66677 0 0 0 0 0 0 0 0 0 0 A0A8I3SCC7 A0A8I3SCC7_CANLF Vascular endothelial growth factor D VEGFD Canis lupus familiaris (Dog) (Canis familiaris) dopaminergic neuron differentiation [GO:0071542]; fibroblast proliferation [GO:0048144]; induction of positive chemotaxis [GO:0050930]; positive regulation of cell division [GO:0051781]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mast cell chemotaxis [GO:0060754]; response to bacterium [GO:0009617]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] extracellular space [GO:0005615]; membrane [GO:0016020] chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; vascular endothelial growth factor receptor 3 binding [GO:0043185] VVNVFMMSYLQLVHSSSY 1 5.1 0.97229 0.048313 0 0 0 0 0 0 0 0 0 0 0 6.36637 0 0 8.07001 A0A8I3SCE0 A0A8I3SCE0_CANLF "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)" SIRT4 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; glutamine metabolic process [GO:0006541]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of glutamine family amino acid metabolic process [GO:0000820]; tricarboxylic acid metabolic process [GO:0072350] mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] lipoamidase activity [GO:0061690]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD-dependent protein biotinidase activity [GO:0106420]; NAD-dependent protein lipoamidase activity [GO:0106419]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; zinc ion binding [GO:0008270] YWARNFVGWPRF 1 3.8 0.95211 0.05044 0 0 0 0 5.09866 0 0 0 0 0 0 0 0 0 0 A0A8I3SCE2 A0A8I3SCE2_CANLF Syntaxin 2 STX2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxidative stress [GO:0034599]; cornified envelope assembly [GO:1903575]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] basolateral plasma membrane [GO:0016323]; extracellular space [GO:0005615]; lamellipodium [GO:0030027]; protein-containing complex [GO:0032991] SNAP receptor activity [GO:0005484]; structural molecule activity [GO:0005198] IKYHSKARRKKWIIVAVS 1 6.2 0.97463 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.84669 A0A8I3SCE6 A0A8I3SCE6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EVRHKLVL;TVLWAWEEVRHKL 2 10.3 0.98606 -0.45203 0 0 0 0 0 0 0 0 0 0 5.91607 0 0 0 0 A0A8I3SCG0 A0A8I3SCG0_CANLF Nitrilase 1 NIT1 Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" QPRECGLWLSL 1 2.2 0.98368 0.035491 0 0 0 8.30022 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SCG9 A0A8I3SCG9_CANLF Protein HIRA HIRA Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] ELLPVIGQNLRFQRLFTECQE;SSDPSMYIE 2 3.1 0.97827 0.047632 0 0 0 0 0 0 0 0 0 8.28072 0 0 0 0 0 A0A8I3SCI3 A0A8I3SCI3_CANLF DNA topoisomerase I (EC 5.6.2.1) (DNA topoisomerase 1) TOP1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; response to xenobiotic stimulus [GO:0009410] fibrillar center [GO:0001650]; male germ cell nucleus [GO:0001673]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993] "ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]" LDHEYTTK;WKWWEEERYPEGIKWKFLEHKGPVF 2 4.3 0.99376 -0.17457 0 0 0 0 0 7.23735 0 0 0 0 0 0 10.8932 0 0 A0A8I3SCI5 A0A8I3SCI5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FNIVDHFYCATTSLLQ;ISYTYIALRILKILS 2 14.3 0.99368 -0.15949 0 0 0 0 0 5.10664 0 0 0 0 0 0 0 0 0 A0A8I3SCI9 A0A8I3SCI9_CANLF Olfactory receptor OR6C33 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LFPFLLLTYVLSI;LLDYRLQTPMYFFL;LVVVVPHTMTLQLPFCASN;TYVLSIMGN 4 15.6 0.99152 -0.29566 0 0 0 0 0 6.83314 0 0 0 0 0 0 11.4695 0 11.646 A0A8I3SCJ5 A0A8I3SCJ5_CANLF Piwi like RNA-mediated gene silencing 1 PIWIL1 Canis lupus familiaris (Dog) (Canis familiaris) piRNA-mediated retrotransposon silencing by heterochromatin formation [GO:0141006]; primary piRNA processing [GO:0140990]; regulation of translation [GO:0006417]; sperm DNA condensation [GO:0035092] chromatoid body [GO:0033391]; dense body [GO:0097433]; nucleus [GO:0005634] mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727] PQWALYQYHIDYNPLMEARRL;VISLTLHYPALQ 2 3.7 0.99205 -0.14457 0 0 0 0 0 0 0 8.67857 0 0 0 0 0 0 0 A0A8I3SCJ6 A0A8I3SCJ6_CANLF "FYVE, RhoGEF and PH domain containing 1" FGD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] EVDSDLDEEDDEE;LEPVQRIPRYELLLK;PQHHRALRFSYHLE;QQFLLPELEKRMEEWDR;SIPVPLADPHRPGSQEVDSDLDE;VAASGATAEPSEAP 6 9.9 0.99371 -0.057892 0 0 0 9.03392 0 0 13.3656 0 4.36821 0 0 6.09641 9.63221 0 0 A0A8I3SCJ7 A0A8I3SCJ7_CANLF Patched domain containing 1 PTCHD1 Canis lupus familiaris (Dog) (Canis familiaris) excitatory chemical synaptic transmission [GO:0098976]; inhibitory chemical synaptic transmission [GO:0098977]; long-term memory [GO:0007616]; short-term memory [GO:0007614]; smoothened signaling pathway [GO:0007224]; social behavior [GO:0035176]; thalamus development [GO:0021794] plasma membrane [GO:0005886]; synapse [GO:0045202] EYTTAQQKY;YGTFEMLSSWRKTRED 2 2.8 0.9903 -0.21127 0 10.637 0 0 0 0 0 0 0 0 8.8448 0 0 0 10.8953 A0A8I3SCJ8 A0A8I3SCJ8_CANLF BRCA1 associated protein BRAP Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] VLSPDICAYCLHKYLSFLPVE 1 3.8 0.99217 -0.20686 0 0 0 12.0601 0 9.69864 0 0 0 0 0 0 0 0 0 A0A8I3SCK6 A0A8I3SCK6_CANLF Transmembrane protein 132D TMEM132D Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLKEANQDIMRNSSLQ;GVFCLAIMVFLINCVTFA;QEWGSQGGQSYGSS 3 4.4 1.0021 -0.65283 0 0 0 11.4459 0 0 0 0 0 0 0 0 0 14.9866 0 A0A8I3SCK7 A0A8I3SCK7_CANLF Phosphatidylinositol-glycan biosynthesis class X protein PIGX Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] GKLPGRLA;NIEAPNYLSKE;VGARRRLPSRSLATRRRAL;VLIYARQDSQCIDCFQAFLPVHYR;VPGGGGGK;YLSKESEVLIYARQDSQCI 6 18.2 0.98776 -0.48243 0 0 0 0 0 0 0 0 0 0 8.49897 0 0 10.6835 0 A0A8I3SCL1 A0A8I3SCL1_CANLF STE20 related adaptor beta STRADB Canis lupus familiaris (Dog) (Canis familiaris) cell morphogenesis [GO:0000902]; JNK cascade [GO:0007254]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein export from nucleus [GO:0006611] aggresome [GO:0016235]; cytosol [GO:0005829]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539] GVDSGIGE;LVSSGTRTGNSDRLQ;NITTYWTVFTVGSWLWV;TVFTVGSWLWVISPFMAY;VGSWLWVISPFMA 5 11.4 1.0022 -1.456 0 0 0 9.96167 9.4874 0 0 8.12676 0 0 0 0 8.86295 0 9.07138 A0A8I3SCM9 A0A8I3SCM9_CANLF Reactive oxygen species modulator 1 (Protein MGR2 homolog) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LMGGIGKTMMQGG 1 16.5 0.99426 -0.059923 9.79521 0 0 0 0 0 0 0 0 0 9.76137 0 0 0 0 A0A8I3SCN0 A0A8I3SCN0_CANLF C2 calcium dependent domain containing 6 C2CD6 Canis lupus familiaris (Dog) (Canis familiaris) sperm principal piece [GO:0097228] FNIFFKYNQF;IDRLLESG;IEPSMFMNIAPPP;KMKYPLNKSL;RKPILSPKLRIFLE;SPQPPHFRGIPT;VPFIKEEAETVPSELPDNDDKKD;VTIGMPPAVS 8 5.5 1.0031 -1.5026 0 0 0 0 0 5.70788 10.6138 0 9.6995 0 0 0 0 9.15033 0 A0A8I3SCN6 A0A8I3SCN6_CANLF Calcium and integrin binding family member 3 CIB3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion homeostasis [GO:0055074] calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287] EVSLVCEKVLD;LTRGELSAEEVSLVCEKVLDEAD 2 16.7 0.9908 -0.51407 0 0 0 0 0 0 9.41481 0 0 0 0 0 0 12.9816 0 A0A8I3SCN8 A0A8I3SCN8_CANLF Uncharacterized protein C33H3orf38 Canis lupus familiaris (Dog) (Canis familiaris) FYYNTSEQNVI;ITFESSDL 2 6.1 1.0021 -1.394 0 0 8.66828 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SCP1 A0A8I3SCP1_CANLF "Spectrin beta, non-erythrocytic 5" SPTBN5 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041] apical cortex [GO:0045179]; cell junction [GO:0030054]; cortical actin cytoskeleton [GO:0030864]; microtubule associated complex [GO:0005875]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381] actin filament binding [GO:0051015]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; opsin binding [GO:0002046]; spectrin binding [GO:0030507] AQVSAHGAHVHHLALQT;DLRGLEAQ;EQTVQRRLAKILLQL;FSRLHQEQTVQRRLAK;GVWAQLHSEE;LQASVGLYQFYQLSNLELTWVAEH;NSRWKSFHGNL;PQPCSSSGDGCHG;QAWERQEEKLQTVHREQLF;QDLEDGWNFLEFLRRADL;QIRKHKELERD;SLRHKHEELQVEVKAHQ;VEQKLLQPG;VLSSVEQMESWL;VQQEGQQLIDSGHFMSLEVAGCL;YYHHFSRLHQEQ 16 5.9 1.0031 -2.4842 9.64017 9.59201 11.4585 9.39536 8.0321 4.9782 13.1185 9.32224 11.7691 0 0 0 9.70352 0 6.59024 A0A8I3SCP6 A0A8I3SCP6_CANLF EWS RNA binding protein 1 EMID1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] ATAPASYSSTQPTSY 1 2.5 0.95449 0.053882 0 0 0 0 8.12541 0 0 0 0 0 0 0 0 0 0 A0A8I3SCQ2 A0A8I3SCQ2_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) BAP1 Canis lupus familiaris (Dog) (Canis familiaris) common myeloid progenitor cell proliferation [GO:0035726]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; hematopoietic stem cell homeostasis [GO:0061484]; in utero embryonic development [GO:0001701]; leukocyte proliferation [GO:0070661]; macrophage homeostasis [GO:0061519]; mitotic cell cycle [GO:0000278]; monoubiquitinated protein deubiquitination [GO:0035520]; myeloid cell apoptotic process [GO:0033028]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cellular homeostasis [GO:0070050]; neutrophil differentiation [GO:0030223]; nucleate erythrocyte differentiation [GO:0043363]; platelet morphogenesis [GO:0036344]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of inflammatory response [GO:0050727]; thrombocyte differentiation [GO:0002574]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; PR-DUB complex [GO:0035517] chromatin DNA binding [GO:0031490]; cysteine-type deubiquitinase activity [GO:0004843]; histone H2A deubiquitinase activity [GO:0140950] EDDYEDDEDDD;ESHSSLLQQRSG;GRSRSHTCEHLSISS;QQYSDDEDDYEDDEDDDVQNT;QYSDDEDDYEDDEDDDVQNT;SDDEDDYED;SDDEDDYEDDEDDDVQNTNS;YSDDEDDYEDDEDDDVQNT;YSDDEDDYEDDEDDDVQNTN 9 6.6 0.99075 -0.21323 0 0 4.27583 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SCQ6 A0A8I3SCQ6_CANLF Coiled-coil domain containing 186 CCDC186 Canis lupus familiaris (Dog) (Canis familiaris) QELILDIFQQL;SEQIASFPGGDFTKQVL;SEQIASFPGGDFTKQVLK 3 3.5 0.97927 0.035491 0 0 0 0 0 0 0 9.0068 0 0 0 0 0 0 0 A0A8I3SCQ8 A0A8I3SCQ8_CANLF Protein-serine/threonine kinase (EC 2.7.11.-) PDK3 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to fatty acid [GO:0071398]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377] mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740] LANTMREVNLLPDNLLNRP;LELLEYENKSPEDPQVLDNFLQVL;QSWYMQSFLE;VQSWYMQSFLELLEYE 4 12.7 0.98598 -0.45176 11.0954 6.78306 0 8.23108 0 7.64422 0 0 0 11.6939 0 0 0 0 0 A0A8I3SCR5 A0A8I3SCR5_CANLF Syntaxin 19 STX19 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] LVKEVKKSE;LVKEVKKSEAEN 2 4.1 0.99012 -0.20185 0 10.4962 0 0 0 0 0 0 0 8.6768 0 0 0 0 0 A0A8I3SCS7 A0A8I3SCS7_CANLF Calsequestrin CASQ1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017] calcium ion binding [GO:0005509] ADSVWMEMDDEEDL;AGEINTEDDDEEEDDDDDD;DWLEDVLAGEINTEDDDEEEDDDDD;EFSADTLV;GGGGGRPG;GGRGGGGG;NTEDDDEEEDDDDD;VGGGGLGQ;VLAGEINTEDDDEEEDDDDDD 9 12 0.98947 -0.51984 0 0 0 0 8.1574 0 6.1049 10.3274 5.29715 0 0 0 0 0 6.59869 A0A8I3SCS8 A0A8I3SCS8_CANLF Alsin Rho guanine nucleotide exchange factor ALS2 ALS2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] DTIYEGEFSDDWTL;EVTSPEYQKLQDSSSC;GVTLSESQAENQAST;GVVVTQFGLYYEGNFHLNK;ISDSHCCP;LPSQDLKPVPERCNQCSQLLITMTD;NQEVFENTLVEN;PLATLWAE;PYGSGSSIQRQE;SEDDTIYEGEFSD;SSIGPEGL;TSALNSLVVSCASAVGV;TTGGDAISSQQEIMGTTEIPS;VTQFGLYYEGNF 14 11 0.99765 -3.3706 0 6.456 0 7.21587 11.4939 9.12166 0 8.09998 14.3851 0 0 6.25041 9.01058 0 10.3493 A0A8I3SCT3 A0A8I3SCT3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FLMEFEDSTGKSGESRG 1 14.9 0.9862 -0.25964 0 8.49438 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8I3SCU1 A0A8I3SCU1_CANLF Fibronectin leucine rich transmembrane protein 1 FLRT1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886] EEYVVHTIFP;ELRLDDNRIS;GAICWYVHRAGE;GAKTLAIH;GEGAKTLA 5 6 0.99865 -3.0197 3.98322 0 0 0 8.17632 0 10.5612 9.69166 0 0 0 0 0 0 0 A0A8I3SCV3 A0A8I3SCV3_CANLF Putative protein-lysine deacylase ABHD14B (Alpha/beta hydrolase domain-containing protein 14B) ABHD14B Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] cytoplasm [GO:0005737]; nucleus [GO:0005634] hydrolase activity [GO:0016787]; transferase activity [GO:0016740] HTGLLDFL 1 3.8 0.98872 -0.26444 0 0 0 0 0 0 0 0 0 9.19495 0 0 0 0 9.26913 A0A8I3SCW0 A0A8I3SCW0_CANLF Solute carrier family 26 member 6 SLC26A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509]; secondary active sulfate transmembrane transporter activity [GO:0008271] IFALRHGYRVDSNQE;SLVGYAFT;VLGQVTDTDIYQDVA 3 5.9 0.98778 -0.49426 0 9.01419 0 0 0 0 0 0 9.3881 0 0 0 0 10.8463 0 A0A8I3SCW5 A0A8I3SCW5_CANLF Retinoic acid induced 2 RAI2 Canis lupus familiaris (Dog) (Canis familiaris) GGSNPAQPPGQPGGDVKA;IKLKKVNSQEIHM 2 5.9 0.99065 -0.51543 0 0 0 0 0 9.22798 0 0 9.86714 0 0 0 0 0 0 A0A8I3SCX1 A0A8I3SCX1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) BRAF Canis lupus familiaris (Dog) (Canis familiaris) "CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [GO:0043369]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to xenobiotic stimulus [GO:0071466]; endothelial cell apoptotic process [GO:0072577]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERK1 and ERK2 cascade [GO:0070371]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of axon regeneration [GO:0048680]; positive regulation of axonogenesis [GO:0050772]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of T cell differentiation [GO:0045580]; somatic stem cell population maintenance [GO:0035019]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic vesicle exocytosis [GO:0016079]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trehalose metabolism in response to stress [GO:0070413]; visual learning [GO:0008542]" cell body [GO:0044297]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110] DLSKVRSN;EIVFDFEPG;SIAETALTSGSSPSA 3 4 0.99384 -0.12087 0 0 0 0 0 0 0 0 0 9.88981 9.8588 0 0 0 0 A0A8I3SCX2 A0A8I3SCX2_CANLF Prickle planar cell polarity protein 3 PRICKLE3 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ACYEARHAEYC;DFQRHSISDDDSGC;ETATKGTSTEPGPVVGPEE;ISDDDSGCASEEY;MGHFCCFECEAS;SSESSEEDGFFLGE 6 12.9 0.99346 -0.0086085 5.88164 0 0 0 0 0 0 0 0 6.2847 10.5073 0 6.7974 0 8.89884 A0A8J8 ANGP2_CANLF Angiopoietin-2 (ANG-2) ANGPT2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; Tie signaling pathway [GO:0048014] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; receptor tyrosine kinase binding [GO:0030971] LVSKQNSIIEEL;NPSGEHWLGNEFVFQVTNQQPYVLK;NQTAEQTRKLTDVE 3 10.3 0.99465 -0.11745 0 0 0 0 0 0 10.0325 9.35072 0 0 0 0 10.5468 9.66192 0 A0A8P0N3B7 A0A8P0N3B7_CANLF sulfite oxidase (EC 1.8.3.1) SUOX Canis lupus familiaris (Dog) (Canis familiaris) heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; oxidoreductase activity [GO:0016491] QESPHLYTREEVRA;VLAKAGHQLCETEAHV 2 5.5 0.98971 -0.52957 0 0 9.9976 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N3C2 A0A8P0N3C2_CANLF Ankyrin repeat domain 52 ANKRD52 Canis lupus familiaris (Dog) (Canis familiaris) EVRSLLSQKENINV;VLGYSRWLPAPP 2 2.8 0.9912 -0.1857 0 0 11.3798 0 0 0 0 12.314 0 0 0 0 0 0 0 A0A8P0N3D5 A0A8P0N3D5_CANLF E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) RNF41 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] TSAEHKHQLAEQ;TSAEHKHQLAEQRDIQ 2 5.1 0.99311 -0.28081 0 0 0 0 12.106 0 0 0 0 0 0 0 0 0 0 A0A8P0N3F4 A0A8P0N3F4_CANLF Chromosome 1 C18orf54 homolog C1H18orf54 Canis lupus familiaris (Dog) (Canis familiaris) AVQESFNQ;CDSEHSHCQCENPVL;FSFTNIGLSHRISKK;LMNKLDCFEYSFEPSNISDSL;SLLASCSLSGSNSSNSDG 5 15.5 0.98726 -0.36542 8.02956 0 0 0 0 0 0 6.82553 9.73462 0 8.59753 0 0 0 9.71699 A0A8P0N3G0 A0A8P0N3G0_CANLF Dmx like 1 DMXL1 Canis lupus familiaris (Dog) (Canis familiaris) AEEELLNMLPAMQKED;ATYKSILRKKVL;DDDDDDDDDDVLASDFHLQ;DDDDDDVL;DELFQIPTL;HPLQLLELMDLGKVRRAK;ITSLSLSENNEKSGP;KRCLNESLEDNCET;NPGDHCFSVGSVGDQRFTAY;SDDDDDDD;SDDDDDDDD;SELARINSLHVSAFS;SLESDDDDDDDDDD;SLESDDDDDDDDDDV;SRAEYDSEESLESDDDDDDDDDDV;TDSLSTLDENDIL;WHVDWLDEYQPGM;WSKNADMLFSI;YCSDGEDL;YVMHTLAA 20 6.7 0.92297 0.095176 0 0 0 0 0 0 0 7.85244 0 0 0 0 0 0 0 A0A8P0N3L0 A0A8P0N3L0_CANLF Glutamate metabotropic receptor 1 GRM1 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206] plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled receptor activity [GO:0004930] TEEDELEEDDDE;YFLKLRLDTNTRNPWFPEFWQHRFQ;YGIQRVEAMFHT;YIAFTMYTTC 4 4.9 0.98832 -0.22689 0 0 0 0 4.00782 0 0 3.7073 0 0 0 0 0 0 7.8993 A0A8P0N3L3 A0A8P0N3L3_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (EC 3.1.4.1) (EC 3.6.1.9) (Alkaline phosphodiesterase I) (Dinucleoside polyphosphatase) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (Phosphodiesterase I beta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) ENPP3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676] CKQRGDCCWDFEDTC;CWDFEDTCV;DMECKQRGDCCWDFEDTCVEST;IRARNIPHDFYSFNSEEIV;ISTLLKWL;LVLPMEETV;SECPEGFE;VSHSRVTHSVF 8 8.2 1.0027 -2.5117 0 7.98425 4.24245 10.3578 0 6.89881 0 0 10.6799 5.4574 0 0 10.0116 0 11.1411 A0A8P0N3M6 A0A8P0N3M6_CANLF SAM and SH3 domain containing 1 SASH1 Canis lupus familiaris (Dog) (Canis familiaris) AEQRGPEARAQAKPP;EMKKGLGSLSHGRTCSF;GVKLGPAL;KPFFFDGSP;NSTRRVRKKLIR;RVRKKLIRVE;VGYVASEITMSDEERI 7 6.7 1.0032 -2.3196 8.89236 0 0 0 9.77888 0 0 10.6781 0 0 3.45983 0 0 0 5.31045 A0A8P0N3P7 A0A8P0N3P7_CANLF Pleckstrin homology and RhoGEF domain containing G1 PLEKHG1 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AQDIQKVSREEGSPQ;DSLQFSEDEAPYHQGP;EADFSEDPCT;GPSPNQQNIVQSLREKFQC;KPVQRILK;KVRSPELEQPLASQQHKST;PQENEDDED;QENEDDED;SYEDLKLMVAKREEAEST;YHFNSELLQDLENCE 10 9.3 1.004 -1.9994 0 3.48091 8.85106 0 0 10.1566 8.30214 13.1656 15.1812 0 6.69377 0 0 0 0 A0A8P0N3Q0 A0A8P0N3Q0_CANLF Zinc finger and BTB domain containing 2 ZBTB2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAGGGGGG;ASRRRLHPGLCGRGRGR;SEGRGAPRGRWRLRLAP 3 4.8 0.93493 0.092454 0 0 10.2212 0 0 0 0 0 8.7699 0 0 0 0 0 0 A0A8P0N3S9 A0A8P0N3S9_CANLF Phosphatidylserine lipase ABHD16A (EC 3.1.1.23) (Alpha/beta hydrolase domain-containing protein 16A) (Monoacylglycerol lipase ABHD16A) ABHD16A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EEDWCLSVLRSYQA;EVEEDWCLSVL;PDISAVILDASFDDLV 3 6.1 0.99402 -0.078912 0 0 0 0 0 0 8.11291 8.02081 10.8906 0 0 8.35852 0 0 0 A0A8P0N3W2 A0A8P0N3W2_CANLF Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48) EIF3E EIF3S6 INT6 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732] "eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; PML body [GO:0016605]" translation initiation factor activity [GO:0003743] IAHFLDRHLVFPLL;VECLYVNFDFD 2 5.7 0.98433 -0.23839 0 3.44533 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N3W4 A0A8P0N3W4_CANLF Ig-like domain-containing protein LY6G6F Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] RCLMPHNKGVSFSL;VGQHYNYQNWRVY 2 9 0.91043 0.12062 0 0 0 0 9.56803 0 0 0 4.82909 0 0 0 0 0 0 A0A8P0N3W9 A0A8P0N3W9_CANLF Choline transporter-like protein SLC44A4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] organic cation transmembrane transporter activity [GO:0015101] CFWIYRRKEEMRCQTGRI;EEEEVRDAPDPGQHPSCTAS;GVPWDMPVIQ;LSLLFILLLRLV;LSLLFILLLRLVAGPLVLVL;LVLSLLFILLLRL;LVLSLLFILLLRLVAGPLV;VGEVFYTA;VGEVFYTANRNFCL;VLALFWTVN 10 12.2 1.0031 -2.2892 7.4099 9.35903 7.31931 0 8.64839 11.7486 0 0 6.71493 0 0 4.57204 0 0 0 A0A8P0N3X1 A0A8P0N3X1_CANLF Dihydropyrimidinase DPYS Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" GVNSFKMFMAYK;GVVRALGRHLLPPG;NIFEGMVCHGVP;RALGRHLLPPG;STPDFLMNLLANGDL 5 10.3 0.99818 -0.60684 0 0 0 0 3.69688 0 0 11.0733 0 8.01542 12.6785 0 0 0 0 A0A8P0N3Y0 A0A8P0N3Y0_CANLF Regulating synaptic membrane exocytosis 2 RIMS2 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; intracellular protein transport [GO:0006886] membrane [GO:0016020]; synapse [GO:0045202] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] DDEDVDSRDEYERQRREEEYQARY;EPHWYKLQTHDVSSLP;GVCIAKKKTKVARKTL;ISITSPMSPG;LVDPTLAPLTRRASQ;PRSRYSQNIE;RMDHKSFMG;RQMKINKYKQVAGS 8 6.8 0.99372 -0.1722 13.1479 13.2059 13.2297 0 0 8.33181 12.7988 12.8616 8.19933 12.0241 12.0411 12.153 13.134 13.1993 13.3137 A0A8P0N3Y1 A0A8P0N3Y1_CANLF CDC42 small effector protein 2 CDC42SE2 Canis lupus familiaris (Dog) (Canis familiaris) phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of Rho protein signal transduction [GO:0035023] cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] small GTPase binding [GO:0031267] VGCLPACRCSLWTQRL 1 12.9 0.98203 -0.25112 9.0842 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N401 A0A8P0N401_CANLF Ig-like domain-containing protein LOC481727 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HLPSLLLL 1 2.1 0.98971 -0.26592 0 0 0 0 0 0 0 0 0 0 9.18267 0 0 0 0 A0A8P0N407 A0A8P0N407_CANLF ABC-type antigen peptide transporter (EC 7.4.2.14) TAP1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885] TAP complex [GO:0042825] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC protein binding [GO:0042287] IGFFHDSRQ;SFLLYQEDL;TVIPYYSG;VGQKQCLAIAR 4 5.4 1.002 -1.4336 0 0 0 0 0 0 0 0 0 10.251 0 0 0 0 0 A0A8P0N414 A0A8P0N414_CANLF Notch receptor 4 NOTCH4 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023] AAGGGGAA;CEGRGGDGACDAGCSGP;DCSEDVDECE;DECLDRPCHPTGTAA;DGACDAGC;EEDINECASSPCANG;FTGQRCQTL;GVILLALGALLVLQLIRRR;GVILLALGALLVLQLIRRRRR;IEDNCTCHHGHCQRSSCVCDVG;LVLQLIRRRRR;PAAAGAGSG;PVAGVILLALGALLVLQLIRR;QAAMLTPPQESEMDVPD;QNGGSCQALLPALPGSPG;TCQCAPGFLGETCQFPD;VPCAHGGT 17 9.5 0.99727 -3.5715 7.31234 0 9.88998 0 10.5869 11.3675 7.51617 5.51422 8.71987 4.9079 6.57237 10.0579 10.3283 9.96029 7.22448 A0A8P0N416 A0A8P0N416_CANLF RAD21 cohesin complex component RAD21 Canis lupus familiaris (Dog) (Canis familiaris) sister chromatid cohesion [GO:0007062] cohesin complex [GO:0008278]; nucleus [GO:0005634] DPVEPMPT;KAKRKRKL;TVKETKAKRKRKL;VGNISILQENDFG 4 5.6 1.0022 -1.2458 0 7.89996 9.64306 0 0 0 4.68061 0 0 0 0 0 0 8.84392 0 A0A8P0N428 A0A8P0N428_CANLF Interferon regulatory factor 1 IRF1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] MMGRHRPIGALAAPREAGPGLG;SLRDRARRKDT 2 7.6 0.99277 -0.19256 0 0 0 4.9803 10.5337 0 0 0 0 0 0 0 0 0 0 A0A8P0N433 A0A8P0N433_CANLF Sulfotransferase (EC 2.8.2.-) LOC612537 Canis lupus familiaris (Dog) (Canis familiaris) sulfotransferase activity [GO:0008146] GDGFLFKFKGYYFYR;TIGDWKNHMTVE 2 9.3 0.9331 0.10497 0 0 0 0 0 0 5.99037 7.07585 0 0 0 0 0 0 0 A0A8P0N437 A0A8P0N437_CANLF Derlin DERL1 Canis lupus familiaris (Dog) (Canis familiaris) response to stress [GO:0006950] endoplasmic reticulum membrane [GO:0005789] FGTRFKACYLPWVI;WVQELDFFIWSIYISY 2 8.7 0.91519 0.11018 0 0 0 0 0 0 8.97424 0 0 0 0 0 0 0 0 A0A8P0N452 A0A8P0N452_CANLF "Major histocompatibility complex, class II, DP beta 1" Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] LPLPVSLPLSLSLSASSAPY 1 8.2 0.95469 0.049417 8.59429 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N467 A0A8P0N467_CANLF Ral guanine nucleotide dissociation stimulator like 2 RGL2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AAWGEATRDSLRVFSSL;EEEDEAPVSVWDE;EEEEEDEAPVSVWDEEENG 3 4.6 0.99089 -0.26949 0 0 0 0 0 0 0 0 0 0 0 11.8464 0 0 0 A0A8P0N471 A0A8P0N471_CANLF Ribosomal RNA processing 7 homolog RRP7 Canis lupus familiaris (Dog) (Canis familiaris) CCCCCRCQ;CCCCCRCQPQP;EAQGCCCC;HEAQGCCCCC;QGCCCCCRC 5 5.6 0.99703 -3.589 6.17596 0 0 2.14984 0 0 0 0 0 6.01451 0 0 0 0 3.20663 A0A8P0N475 A0A8P0N475_CANLF Zinc finger CCCH-type containing 7B ZC3H7B Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; miRNA binding [GO:0035198] GVKRGSLTIAKLLKEH;IVRSTSLKYS;KDMLLCPRDDDFGKYNF;LPGTESLDDFSDGDVF;MERQRRKADIEKGLQFIQ;QELLCKLHVNRAAC 6 9.4 1.0012 -0.92172 0 5.23684 0 0 10.5939 0 0 0 10.0932 5.09866 0 8.27114 0 0 0 A0A8P0N4A5 A0A8P0N4A5_CANLF Tribbles pseudokinase 1 TRIB1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] IIKGEDDALSDKHG;SPQPPPAVP;VPDYQEDSDIS 3 9.1 0.98768 -0.4645 0 0 0 0 0 10.654 0 0 0 0 8.60929 0 0 0 0 A0A8P0N4A6 A0A8P0N4A6_CANLF Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) SMAD5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] metal ion binding [GO:0046872] EKAVDALVKKLKKKKG;LVQFRNLSHNEPH;NKSRFCLGLLSN;PLSPNSPYPP;VDALVKKLKKKKGA 5 11.2 1.0031 -1.3363 0 0 0 9.63067 9.13036 0 0 6.0857 0 0 10.4897 0 0 4.39142 0 A0A8P0N4A8 A0A8P0N4A8_CANLF Olfactory receptor OR2L17 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FPLHYPIRI;IGLCFFILIVLI;INHFFCEVPAMLTLACMDTWV 3 13.5 0.98954 -0.22268 0 0 0 0 0 0 0 0 0 0 0 8.33713 0 0 4.86047 A0A8P0N4B2 A0A8P0N4B2_CANLF Thyroglobulin TG Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446] extracellular region [GO:0005576] carboxylic ester hydrolase activity [GO:0052689]; hormone activity [GO:0005179] ETLFRKKVI;FLQGDRFG;FLSSGSGELSGNWGL;GILRPMVEG;GYFSQHSLFLAP;LDQVIVNGSQSLPSQ;LDQVIVNGSQSLPSQQ;PTFSSSYI;QTQGQFQL;RLLHGVGDKSPP;SLKIMQFFSNF;SWDATKPRASCWQP;TFAETTLYRILQRRF;YIQSLKAAADEAKQELS 14 5.6 0.99704 -4.043 0 12.2107 0 8.72253 8.69606 0 0 13.9557 0 0 0 10.1577 7.31606 9.3429 0 A0A8P0N4B4 A0A8P0N4B4_CANLF Kelch like family member 3 KLHL3 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] AACSPYFCAMFTGDMSES;GVLSGQLY;LVQTVEEEAL;LVQTVEEEALIKNNN;VECYDFEE 5 8.9 1.0039 -2.0258 0 0 0 7.64976 0 8.46675 0 0 11.9706 0 0 7.50867 0 0 0 A0A8P0N4C3 A0A8P0N4C3_CANLF Butyrophilin-like protein 10 LOC482200 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAGRVSFYNVGSGSLIYTFSGLSFS;FLQLLSCSIPGNGKADFSVFAP;SVPLRPFFCLWTHDP 3 12.6 0.87077 0.13681 0 0 0 0 0 6.9956 0 3.31089 0 7.86196 0 0 9.50273 0 0 A0A8P0N4D6 A0A8P0N4D6_CANLF Bromo domain-containing protein BRD8 Canis lupus familiaris (Dog) (Canis familiaris) DAPGEDEEEDG;EMDNEPPVSESDD;STECDDGFSIQ;VGSWRETEEP;VIKETQEKYRRLKR 5 4.8 1.0016 -0.74966 6.86925 0 0 0 0 10.1306 2.85509 0 0 0 0 0 3.54535 0 0 A0A8P0N4G4 A0A8P0N4G4_CANLF Trinucleotide repeat containing adaptor 6B TNRC6B Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytosol [GO:0005829] RNA binding [GO:0003723] ASREQQSKMENAGV;ENAGVNFVVSG;GASSNNGA;GVNFVVSGREQAQ;HSTSAKFPDYKS;HSTSAKFPDYKST;KPHLDNMV;PNLPTPMTSKSASDSKSM;QEAAKAQTALHMCVL 9 5 1.0028 -2.5188 11.3825 0 10.7414 4.98627 4.95084 0 0 0 7.28716 0 9.6397 0 11.4514 11.2131 0 A0A8P0N4H7 A0A8P0N4H7_CANLF Family with sequence similarity 83 member F FAM83F Canis lupus familiaris (Dog) (Canis familiaris) FSKRFFSRRAKSPTAPN;VSRITVFTHP 2 5.3 0.98972 -0.522 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.5031 A0A8P0N4J4 A0A8P0N4J4_CANLF Patatin like phospholipase domain containing 1 PNPLA1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] hydrolase activity [GO:0016787] HRFAGTSAGAVVAALV;RHPRSKKTGGKV;VESPVSPPVPSL 3 7.1 0.98687 -0.38477 0 0 11.0915 0 0 0 0 0 0 0 0 9.16194 8.54473 0 0 A0A8P0N4J6 A0A8P0N4J6_CANLF "RAB44, member RAS onco family" RAB44 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] AASFLALEEADHEEKEAFFAFIQQ;FSSGLKNIFSSSLG;GAQPGDGA;GNKTDREEERQVPIEAGQQL;PGLFGEEDDWDQL 5 8.2 1.0013 -0.93971 0 8.63757 0 3.58015 7.539 0 0 0 10.1153 0 5.74878 0 0 9.83525 9.59669 A0A8P0N4L2 A0A8P0N4L2_CANLF Plectin PLEC Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cytoskeleton [GO:0005856] actin binding [GO:0003779] APATDERDRVQKK;DEELQRLKAE;DGRHPQGE;EAEIALKEKEAEN;EDVRLQAEEAERRLRQAEA;EQEAVRRAQAEQAA;EQESARQLQLAQEAA;EQLFRDEV;ETSRALSAP;IDHQTYLELS;IIIEIIEKTEIVRQQN;LDQETSRALSAPQDE;LTYLQLME;LYRQLQRGERSVRE;PSVEAQLGSHRGL;RAMASLRARGLVRETFAWRHFYWY;RLQLEETDHQK;RQLQEDKEQMAQQL;RRDLLRQFRMGKVTVEKIIKIV;SPATSRTQ;TFAWRHFYWY;VIDHNLYRQ;VQTLKDGRHPQGEQ;YLDPSTDERLSYTQL 24 6 0.99702 -6.8856 9.18757 9.3621 0 6.37034 4.12251 12.8962 12.8451 9.67135 13.1443 3.74835 8.31148 10.9514 4.62422 0 11.8071 A0A8P0N4L3 A0A8P0N4L3_CANLF FERM domain containing 3 FRMD3 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; membrane [GO:0016020] KEEPLTISELA;KFLGSERGWAD;PENYINEFEIFPKQSQ 3 6.2 0.98824 -0.47323 0 9.87234 0 0 0 0 0 0 0 0 0 0 0 5.57428 0 A0A8P0N4L7 A0A8P0N4L7_CANLF Peptidase inhibitor 16 PI16 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] LGLLLLLPLVLAG;LLLLLLLL;LLLLLLLLL;PSGYRCESSLCE;QGVEETNIHLLV 5 10 0.98677 -0.45748 0 13.0967 0 0 0 0 0 0 0 0 8.27342 0 0 0 0 A0A8P0N4M2 A0A8P0N4M2_CANLF Galectin LGALS1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] NLSLKPGQCLR 1 8.3 0.98015 0.035491 0 0 0 0 0 8.6291 0 0 0 0 0 0 0 0 0 A0A8P0N4M6 A0A8P0N4M6_CANLF Testis expressed 33 CIMIP4 TEX33 Canis lupus familiaris (Dog) (Canis familiaris) GRWHQKNAMNMNLQK;IEHWHGRKTDD;KTDDLGRWHQ;RSPLDTSKFKY 4 13.9 1.0021 -0.67892 0 0 8.51566 9.37071 0 0 9.68242 0 0 0 17.3923 7.95641 0 6.72042 0 A0A8P0N4M7 A0A8P0N4M7_CANLF TRIO and F-actin binding protein TRIOBP Canis lupus familiaris (Dog) (Canis familiaris) CLEIGALMRQAEERE;GGGGGGGG;MLQKDKRFTSGKYQDVY;PALLGPAREPLP;YSTQKGSLKAGEQRGCSE 5 11.4 1.0022 -0.66837 0 0 13.5389 6.26463 0 0 6.28646 0 0 0 0 0 0 9.09532 0 A0A8P0N4P3 A0A8P0N4P3_CANLF SHANK associated RH domain interactor SHARPIN Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] metal ion binding [GO:0046872] CEMCSTQKPCSWDP;PQDRRAAARPPFGPHCIR;SPRKRGRTGDGMAPPSGPG 3 6.2 0.8527 0.15885 0 0 0 9.69758 0 0 0 0 0 0 0 0 0 5.81188 6.19119 A0A8P0N4S7 A0A8P0N4S7_CANLF Tonsoku-like protein (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) TONSL Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; DNA repair [GO:0006281] chromosome [GO:0005694]; nucleus [GO:0005634] AVSHYEQELRLRGGD;LGAREVRIPASGGLSMSAERE;PLETLQQWVKLYGRDLDSET;PLLRALKLHTALRELRLAG;PLSPCPGSPE;RPGSSSSR;TPLLRALKLH 7 7.2 1.0033 -2.1341 0 4.70885 0 9.95169 8.94623 4.83466 7.50827 0 9.25685 0 0 5.38464 4.88923 0 5.51396 A0A8P0N4U9 A0A8P0N4U9_CANLF Tubulin folding cofactor C TBCC Canis lupus familiaris (Dog) (Canis familiaris) post-chaperonin tubulin folding pathway [GO:0007023] cytoplasm [GO:0005737] tubulin binding [GO:0015631] AEGILAFP 1 2.2 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6906 A0A8P0N4V2 A0A8P0N4V2_CANLF Hyaluronidase (EC 3.2.1.35) HYAL4 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] hyalurononglucosaminidase activity [GO:0004415] LAKARGQN;PARLPIYQRKPF 2 4.3 1.0026 -1.3474 0 0 0 0 6.48596 0 12.112 0 0 0 0 0 0 0 0 A0A8P0N4V8 A0A8P0N4V8_CANLF Exonuclease domain-containing protein LOC102152733 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676] EDDLKNTKTSIRDVQ;QQQAVQIM;SEERNLQIS 3 3.6 1.0015 -1.3132 9.92105 7.82101 0 0 0 3.87224 0 0 0 0 4.36015 0 0 0 0 A0A8P0N4W1 A0A8P0N4W1_CANLF BTB domain containing 11 ABTB3 BTBD11 Canis lupus familiaris (Dog) (Canis familiaris) QDLGFRMLNCGRTDLVKQAVS;SVEHGEENYSETP;VGSPVGSPVRS 3 6.9 0.98387 -0.24453 0 8.6761 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N4W4 A0A8P0N4W4_CANLF Hyaluronidase (EC 3.2.1.35) LOC609321 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hyalurononglucosaminidase activity [GO:0004415] DEILRNDQLQW;FYPNELGYYPYFSQD;NPLETQKGST;SEGLIIIDWES;SWWRSEGLIIIDW 5 11.2 0.98749 -0.33712 6.02837 9.28316 0 7.88643 0 0 7.4154 0 10.0974 0 0 6.9216 7.77525 0 0 A0A8P0N4W7 A0A8P0N4W7_CANLF rRNA biogenesis protein RRP36 KLHDC3 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904] HKWSTPRVSGTVPGA;QERRRQQELRLALKQEQRARAQQ 2 7.2 0.91961 0.11487 0 0 0 0 0 0 9.51869 0 0 6.5684 0 0 0 0 0 A0A8P0N4X2 A0A8P0N4X2_CANLF Cullin 7 CUL7 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737] ubiquitin protein ligase binding [GO:0031625] EAIEKHLDFDSR;EDEDAEESEHLTQAEWWE;EDHRRTHRPINIPFFDVFLRYLCQG;EGAVVTNVVEEEEEEEENED;EKHLGKLELAQELRD;FADRFLPDDEAAQA;FYSKSQSYPALEQ;LDDYEEVSAGDEGE;RDRLELEFSMA;RNRSHDWSSL;TSEELQRQFHVYQLQ 11 9.9 0.98687 -0.35993 0 12.0561 7.53862 9.70596 0 7.80284 11.3845 0 9.64066 0 0 0 11.6334 8.96368 0 A0A8P0N4Y8 A0A8P0N4Y8_CANLF Carnitine O-octanoyltransferase CROT Canis lupus familiaris (Dog) (Canis familiaris) acyltransferase activity [GO:0016746] APLDGMVIVNINHYVDQKIFE;EEGLPVPE;HLLGLLLIAKEEGLPVPELFTDPL;NWLEEWWLNFAYLNVRLPSQL;QAFTKHNKMMK;SKSGGGGN 6 14.5 0.97779 0.047632 0 0 0 0 0 0 7.1373 0 0 0 0 0 0 0 0 A0A8P0N4Z7 A0A8P0N4Z7_CANLF Aquaporin-3 (Aquaglyceroporin-3) AQP3 Canis lupus familiaris (Dog) (Canis familiaris) polyol transmembrane transport [GO:0015791] plasma membrane [GO:0005886] channel activity [GO:0015267] IVDPYNNPV 1 3.1 0.98497 -0.25927 0 0 9.35913 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N501 A0A8P0N501_CANLF Heat shock 70 kDa protein 1-like LOC474850 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] CERAKRTLSSSTQANLE;EPTAAAIAYGLDKTGQGE;VLIQVYEGE 3 6.9 0.99565 -0.11679 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9196 0 A0A8P0N504 A0A8P0N504_CANLF "Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2" APPL2 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; ruffle [GO:0001726] QTRWFYLLYNFEK;RNSEMENDRIVPTAEL 2 4.8 0.91491 0.10912 0 0 0 0 0 8.88438 0 0 0 0 0 0 0 0 9.05834 A0A8P0N518 A0A8P0N518_CANLF DNA polymerase eta POLH Canis lupus familiaris (Dog) (Canis familiaris) DNA biosynthetic process [GO:0071897]; postreplication repair [GO:0006301] nucleus [GO:0005634] damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; transferase activity [GO:0016740] ALVDMDCFFV;DLTQNSPSRLASSSSALEVA;LNNPSIFFPPQNPQSSPEEL;LSSLRRCCALTRYD 4 9 0.98654 -0.45075 0 9.86505 9.37393 0 0 0 8.98797 6.81967 0 0 0 0 0 0 0 A0A8P0N531 A0A8P0N531_CANLF HEPACAM family member 2 HEPACAM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HKFTMMPPNA;LVYQWLKN 2 4 1.0029 -1.7158 0 0 0 0 0 0 0 0 10.533 8.24365 0 0 0 0 0 A0A8P0N545 A0A8P0N545_CANLF Coiled-coil domain containing 138 CCDC138 Canis lupus familiaris (Dog) (Canis familiaris) EAPRAGFGGGAT;QEFAEELQK;SEESGMDG;VPLNAQVYELLTVF 4 5.7 0.94638 0.05044 0 0 0 0 0 0 0 0 0 0 8.89827 0 0 0 0 A0A8P0N547 A0A8P0N547_CANLF "SPT3 homolog, SAGA and STAGA complex component" SUPT3H Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] protein heterodimerization activity [GO:0046982] KKLRRLLKYMF;SSMEIKPNVVAME 2 8.5 0.987 -0.23106 0 0 0 0 0 0 0 0 0 0 0 0 8.28332 0 0 A0A8P0N585 A0A8P0N585_CANLF Patched domain containing 4 PTCHD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AIDHCAPLLYTF;EAGGLQHRDE;GVLLVLILTFF;HLKKKKKKKKKAKLSC;KKKKKKAKLS;KKKKKKKK;KKKKKKKKAKLSC;KKKKKKKKKAKL;LKKKKKKKKKA;LKKKKKKKKKAKL;LTVPAVLTIT;QHFRNDIIFSKAG;QHLKKKKKKKKKAKL;QQKYFSNYSPVIGFYIYEPLE;SALNRFQPEG;TAWKVLQGN 16 10.2 1.0032 -2.3722 0 14.9785 0 5.88996 3.88118 5.84922 0 0 5.98235 0 0 0 6.8166 10.8198 4.48285 A0A8P0N588 A0A8P0N588_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) LOC484191 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] EEGLFVVH;GCACDACGFSCHTTCV;QQKRGTLCVDVQEGMGTAYEGH;YISSGSAS 4 7.9 0.99339 -0.16072 6.91085 0 0 0 0 0 0 0 0 10.3335 9.87902 0 0 8.13057 0 A0A8P0N5A1 A0A8P0N5A1_CANLF Tyrosine-protein kinase (EC 2.7.10.2) SYK Canis lupus familiaris (Dog) (Canis familiaris) immune system process [GO:0002376]; intracellular signal transduction [GO:0035556] cytosol [GO:0005829]; membrane [GO:0016020] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] KLCWTYEVDRRPGFEAVEL;LMWEAFSYGQK;QLVEHYSYKP 3 6.6 0.98923 -0.30963 10.7403 0 9.00087 0 0 0 0 0 0 0 11.0116 0 0 0 0 A0A8P0N5A8 A0A8P0N5A8_CANLF "RGP1 homolog, RAB6A GEF complex partner 1" RGP1 Canis lupus familiaris (Dog) (Canis familiaris) LNLGEGTVACLQFSVSLQ;TFGIFKSVYRLGED;VLTGLQDVRFPQ;VPVDTFSWDL 4 14.6 0.99647 -0.11344 0 0 0 10.2183 0 11.003 9.92822 10.9932 10.6858 0 0 0 0 3.32941 0 A0A8P0N5C1 A0A8P0N5C1_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] HNCEVRKTLSKQE;SGSGNFGG 2 8.5 0.92273 0.11963 0 0 0 0 0 0 0 0 0 7.36212 0 7.20535 0 0 0 A0A8P0N5E8 A0A8P0N5E8_CANLF Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) ZCCHC7 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ESPSSKPNQKNLIILS;IEQPKPEE;ISDKDAEAQIVNNRSS;YCYNCGQEGHYGHECT 4 10.3 0.98749 -0.3627 0 0 0 0 0 0 8.01575 0 8.7271 0 0 0 0 0 0 A0A8P0N5F1 A0A8P0N5F1_CANLF Stimulated by retinoic acid gene 6 protein-like LOC102151424 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023] GFSYSLIWF;SSFFLQPKMSAADK 2 3.6 0.99412 -0.18864 0 0 10.1959 0 0 0 0 0 0 0 9.57452 0 0 0 0 A0A8P0N5J1 A0A8P0N5J1_CANLF Otolin 1 OTOL1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] EGKGGPAGLPGAPGDPG;FFLNCCDCCSS;FFLNCCDCCSSVPGQ;GPAPEEEEIPFTEAAEKAEPTP 4 11.7 0.98961 -0.30586 0 0 10.5303 0 5.47333 0 0 0 0 0 0 0 0 0 0 A0A8P0N5N2 A0A8P0N5N2_CANLF Epithelial cell adhesion molecule (Tumor-associated calcium signal transducer 1) EPCAM Canis lupus familiaris (Dog) (Canis familiaris) lateral plasma membrane [GO:0016328] AGIIAVIVVVTLAVIAGIVVL;GLQAGIIAVIVVVTLAVIAGIVVLV;GVRRTDKDTEISCTE 3 13.2 0.99384 -0.17 0 0 0 0 0 4.22743 0 0 4.78173 0 0 7.60318 0 0 0 A0A8P0N5P0 A0A8P0N5P0_CANLF Collagen type XII alpha 1 chain COL12A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] ALAALGAALLLSSI;IETGEKSLPG;IVDDLTIN;PQNIHISDEWYTRFRVSWD;SGESKEVTTPA;SYSFKANWSPAGENV;TDQGTTLYLNV;VTDLKTYQIGWDTFCVR;YALSVTALYASG;YKVEYYPVSGGKRQEFYVSR 10 4.6 0.99017 -0.21135 0 10.0918 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N5P1 A0A8P0N5P1_CANLF Olfactory receptor family 13 subfamily C member 8 OR13C8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SVGANNQDITEVL 1 4.1 0.99052 -0.2102 0 0 0 0 0 0 0 0 0 0 9.33472 0 0 0 0 A0A8P0N5P3 A0A8P0N5P3_CANLF Leukocyte receptor cluster member 8 LENG8 Canis lupus familiaris (Dog) (Canis familiaris) GAGGAGRA;HALALRAA;PPGTGGLK;VLYYIFTKN 4 4.2 1.0041 -1.1044 0 0 0 10.0535 10.1306 10.2594 0 0 0 0 10.0764 0 9.51045 9.32432 9.63731 A0A8P0N5Q2 A0A8P0N5Q2_CANLF Zinc finger protein 462 ZNF462 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DEEDYYGS;DLETNSMLNDSSSD;DNEVEIEVELD;EAQEMEWLPFR;EVELDREEEPTE;HYQKRHDIDAYYTHCLAASRTI;KFCVRYFRSK;KKKKTKTKKKKTKKQK;KTKKKKTKKQKKRKKERKKKEKKEN;LLNTQTPIYGTE;MNRFQCPFCPF;PAEEVEDSNDSSYSEPPDVQQ;PLCLYHTKY;QQEDAVINVEDDEEEEEDN;TKKKKTKKQKKRKKERKKKEK;TKTKKKKTKKQKKRK;TPIYGTEHNNENTD;VGVLVHYQ;YCSFVSAFRHNLD;YTNPIRKGLAAHYQKRH 20 8.8 0.86437 0.18581 0 0 4.19022 0 0 5.57253 6.64832 0 0 0 0 0 0 0 6.40856 A0A8P0N5Q6 A0A8P0N5Q6_CANLF Gamma-glutamylcyclotransferase (EC 4.3.2.7) CHAC2 Canis lupus familiaris (Dog) (Canis familiaris) glutathione catabolic process [GO:0006751] gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928] GGGRAEGGTGGSRSPAAA;GVPGKPGR;NTEYLFELANSMRNLVPE 3 11.3 1.0028 -1.1278 7.82623 0 0 0 0 0 0 0 0 0 0 0 0 11.3791 0 A0A8P0N5S8 A0A8P0N5S8_CANLF Transmembrane protease serine (EC 3.4.21.-) LOC482172 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576]; plasma membrane [GO:0005886] serine-type endopeptidase activity [GO:0004252] DYDSKFEKPYSQEYMDL;FLPRGTESNTKMKL;FVIYEKTPFYHHISFK;HGSKLRRQYVKSH;KTPFYHHIS;VVSLINETFHGSKL 6 16 1.0031 -1.1136 8.36488 10.2456 0 0 8.40684 0 0 10.8507 0 0 0 0 0 9.08226 0 A0A8P0N5T5 A0A8P0N5T5_CANLF hyaluronan synthase (EC 2.4.1.212) HAS1 Canis lupus familiaris (Dog) (Canis familiaris) glycosaminoglycan biosynthetic process [GO:0006024] membrane [GO:0016020] FGLYGAFLSAHLVAQSLFAYLE;MTWAYAAGV;PWEPAAAG 3 7.1 1.0023 -1.0031 0 9.46536 0 0 0 0 0 0 10.1286 0 0 0 0 0 9.91346 A0A8P0N5V5 A0A8P0N5V5_CANLF polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase 1) PPP4R3B PNPT1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA catabolic process [GO:0006402]; RNA processing [GO:0006396] cytoplasm [GO:0005737] polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723] GAVYTATI;HYEFPPYATNEIGKV;TQVFCTVTFDSLESS 3 5.3 0.98565 -0.43588 8.21165 0 0 0 0 0 8.13036 0 0 0 0 0 0 0 6.89105 A0A8P0N5W3 A0A8P0N5W3_CANLF V-set and immunoglobulin domain containing 10 like VSIG10L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AADVRVFYGPDA;ATDREGAEPPRIRTEGDQLL;PGGVPAASLQFQGLPE;TVTPEAPRE;TYKDWISLLTLGP 5 8.1 0.99353 -0.056658 10.7249 0 0 0 0 0 0 0 0 0 11.9007 0 8.3357 9.06628 0 A0A8P0N5W6 A0A8P0N5W6_CANLF Deoxycytidine kinase DCK Canis lupus familiaris (Dog) (Canis familiaris) AAPTAGHV;GGGGGGGG;GGREGGGEEGRREAGV;LIEKIPIPV;MATPPKRSCPSPA 5 9.6 0.98631 -0.41755 9.27822 8.85362 0 0 0 0 9.49542 0 11.8437 0 9.42694 10.0743 0 9.10651 10.9417 A0A8P0N611 A0A8P0N611_CANLF Solute carrier family 46 member 2 SLC46A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] DPDHSDKQSMQG;LTGVVTST;SFGAGAGA;VGLLLKVLL;VGLTPLLSAYALGWLSDRRHR 5 12.1 1.0005 -2.7762 0 0 0 0 0 0 3.94205 0 9.55911 0 7.80703 0 0 9.93611 8.14236 A0A8P0N618 A0A8P0N618_CANLF Solute carrier family 35 member A1 SLC35A1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165] GVILVQWKP 1 4.8 1.0036 -0.80421 0 0 0 0 4.1122 0 0 0 0 0 0 0 0 0 0 A0A8P0N645 A0A8P0N645_CANLF Collagen type XVII alpha 1 chain COL17A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGEPGVQGPPG;DLMDFFRTYGAIP;EAGAFGLDMGLG;GAAEGGMY;GASGGSLGE;GGGGGGGG;GVSSIPGP;GYGGAAEG;LLLTWLLLL;LPAGSSMGT;TGMPGTRGPPGPS;VIGDWSLQSLDYAEL 12 8.5 0.98372 -0.25255 0 0 0 0 0 0 0 0 0 0 0 0 8.92119 0 0 A0A8P0N674 A0A8P0N674_CANLF AP2 associated kinase 1 AAK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] SAPAHKAAEDSNLI;TDLLEEFAPIA;VGYIDSSINNVS 3 4 0.98981 -0.22297 0 0 0 8.97065 0 12.7094 0 0 0 8.42681 0 0 0 0 0 A0A8P0N676 A0A8P0N676_CANLF Aprataxin and PNKP like factor APLF Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302] 3'-5' exonuclease activity [GO:0008408]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906] CQDEADDR;EDGDNGGQP;ERSTEVAETQTT 3 5.7 0.9861 -0.41326 0 0 8.66381 12.5364 0 0 0 0 0 7.34589 11.8609 0 0 0 0 A0A8P0N6B8 A0A8P0N6B8_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] ENLAIFPDTVT;FIIGRRHC;LHQLMLDCWQKERAERPKFEQ;PADNGGRNDVTYRI;PDFTTFCSVGEWLQAIKMERY;SLESVARMTIED;VITEYEIKYYE 7 9.9 1.0026 -1.1631 5.46695 12.2313 0 0 0 0 11.3845 0 10.0557 0 0 0 0 0 0 A0A8P0N6C5 A0A8P0N6C5_CANLF V-set and transmembrane domain containing 2A VSTM2A Canis lupus familiaris (Dog) (Canis familiaris) AGLGRLVPVRRPIRAPAGLYH;SHKLQISKVRKK 2 8.1 0.97623 0.047759 0 0 0 0 0 0 8.54369 0 0 0 0 0 0 0 0 A0A8P0N6C6 A0A8P0N6C6_CANLF "Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)" COQ3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] extrinsic component of mitochondrial inner membrane [GO:0031314] "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [GO:0010420]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]" TRLYSTSQ 1 2.2 0.98514 -0.25337 0 0 0 0 0 0 0 12.619 0 0 0 0 0 0 0 A0A8P0N6C9 A0A8P0N6C9_CANLF Cullin 1 CUL1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] CAYLNRHWVRRECDE;EDRKLLIQAAIVRI;EIFHTEFQNLLDADKNEDL;ELVTNCFKNRYTLQAS;GRPQSWNPASIYQTKYGEIQI;IEDKDVFQKFYAKML;LLDADKNEDLGRMYNLVSRIQDG 7 15 0.95003 0.049735 0 0 0 0 0 0 0 7.46793 0 0 0 0 0 0 0 A0A8P0N6D7 A0A8P0N6D7_CANLF BMP/retinoic acid-inducible neural-specific protein 1 BRINP1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of mitotic cell cycle [GO:0045930]; nervous system development [GO:0007399]; positive regulation of neuron differentiation [GO:0045666] cytoplasm [GO:0005737] CQMRNSSLDPMFF;IIFPQYLQEKFVQSALSYIMCNGEG 2 5.3 0.98623 -0.2353 0 0 0 0 0 0 0 0 0 0 8.83804 0 0 12.3845 0 A0A8P0N6F3 A0A8P0N6F3_CANLF Blood vessel epicardial substance BVES Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] bicellular tight junction [GO:0005923]; lateral plasma membrane [GO:0016328] FLRGTSSMSSL;RGTSSMSSLHVPSPHQRGSAKM 2 6.7 0.94411 0.082814 0 0 9.11108 0 0 5.78125 0 0 0 0 0 0 0 5.51712 0 A0A8P0N6F8 A0A8P0N6F8_CANLF E2F transcription factor 6 E2F6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ENERLAYVTYQDIHSIQAFHEQIVI;KVATKLGV;LDVPAPRE 3 19.8 1.0029 -2.5058 0 7.07425 0 11.9199 0 5.13779 0 0 7.01044 0 0 0 0 6.93817 0 A0A8P0N6F9 A0A8P0N6F9_CANLF Activating signal cointegrator 1 complex subunit 3 ASCC3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676] ALSQIVKLLI;CIEIGEDNRSIEPL;DEVCYESVLKQ;DVSHDSVNKFLSSLVEKS;EAMRTSAFIAGAKM;IERAKNSGQISCFLPSQ;IQSVNEDLNDILQAAKQI;TWTYFFRRLIMNPSYYNLS;VEKYLNATLNEMA;VGLSVKGWWDDSVEGHGELSIT;VLSDHLNAEIAGGT;YIAPLKALVR;YVLQVSLQRVHFGF 13 8.8 1.0029 -1.5153 0 8.2717 10.0101 0 0 0 7.34172 0 9.78851 0 0 8.78542 9.3541 10.3021 9.14124 A0A8P0N6H4 A0A8P0N6H4_CANLF CYFIP-related Rac1 interactor A CYRIA Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin filament polymerization [GO:0030833] membrane [GO:0016020] small GTPase binding [GO:0031267] AEATPMLKTLSNATM 1 4.7 0.94684 0.078477 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4706 A0A8P0N6I6 A0A8P0N6I6_CANLF Origin recognition complex subunit 6 ORC6 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nuclear origin of replication recognition complex [GO:0005664] DNA binding [GO:0003677] PQPIQMQQRWGLGPG;SGLNKKMYQSCLKSFECLLG 2 10 0.98548 -0.23247 0 0 0 0 0 7.15036 0 0 0 0 0 0 0 0 0 A0A8P0N6J1 A0A8P0N6J1_CANLF Coiled-coil and C2 domain containing 1B CC2D1B Canis lupus familiaris (Dog) (Canis familiaris) intracellular membrane-bounded organelle [GO:0043231] "DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]" AAPVVAAEPP;EDADLLTELQEVLGVDE;LERLENECE 3 4.4 1.0021 -1.3031 0 0 0 0 0 0 0 0 0 5.1863 0 0 0 0 3.82334 A0A8P0N6J5 A0A8P0N6J5_CANLF KASH domain containing 5 KASH5 Canis lupus familiaris (Dog) (Canis familiaris) telomere localization [GO:0034397] meiotic nuclear membrane microtubule tethering complex [GO:0034993] HPLIPVPVLGLLLLLLL;IPVPVLGLLLLLLLSILLL;IPVPVLGLLLLLLLSILLLG;LIPVPVLGLLLLLLLSILLL;PLIPVPVLGLLLLLLL;PRHPLIPVPVLGLLLLLLLSILLL;PVLGLLLLLLLSILLLGQ;PVPVLGLLLLLLLSILLLGQSPP;RHPLIPVPVLGLLLLLLLSILL;VLGLLLLLLLSILLL;VPVLGLLLLLLLSILLLG 11 5.1 0.80425 0.20707 0 0 5.40156 0 7.89026 0 6.83099 7.03199 0 5.39606 0 5.18729 9.07572 3.77568 0 A0A8P0N6K8 A0A8P0N6K8_CANLF CD37 molecule CD37 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVSDKNGV 1 2.3 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.85882 A0A8P0N6L0 A0A8P0N6L0_CANLF Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.-) (SET domain-containing protein 7) SETD7 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; nucleus [GO:0005634] histone H3K4 monomethyltransferase activity [GO:0140945] GQYKDNIRHGVCWIYYPVSL;TLEGYYVDDALQGQGVYTY 2 10.6 0.93135 0.098727 0 0 0 0 0 7.52356 0 0 0 7.36054 0 0 0 7.85081 0 A0A8P0N6L9 A0A8P0N6L9_CANLF Laminin subunit beta 4 LAMB4 Canis lupus familiaris (Dog) (Canis familiaris) AELCDPETGSCFN;CDQLTGQCRCKLGYDGK;DLEEYQLHNCVE;ERCIDGYYGNPAAGKSCRPCPC;GVDHVSIRLDLEALFQFSH;HLHGCSPCDCDIGGAYSN;LLIKKLKKFL;PGAGPQDS;QPCNCHPS;SLLIKKLKKFL 10 7.3 0.94 0.059589 0 0 0 0 5.77576 0 0 0 0 6.80245 0 0 0 0 0 A0A8P0N6M5 A0A8P0N6M5_CANLF Pleckstrin homology domain containing A4 PLEKHA4 Canis lupus familiaris (Dog) (Canis familiaris) LSSSRSPEADWGRPPGGDRD;PRTKPQEHH;QEEKEQLEAAL;RSPDLFTPLSRPPSPLS 4 9.8 1.0013 -0.70444 0 0 0 0 7.74839 0 0 0 9.62974 0 0 0 0 0 5.79351 A0A8P0N6M7 A0A8P0N6M7_CANLF Adenylate kinase 9 AK9 Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleobase-containing compound kinase activity [GO:0019205] CQRISGQRQHSSTG;EEEPEEDEDDID;EEVMSEEDEEQ;GPHGSGKTT;HNWYVIDGFHNKWWVWNEVTKKL;IIINIKCPDYDLCQR;KLLIPVILINGARKI;KLLIPVILINGARKIHIV;NSKHRKNIVEIRQYYQEQHHNWYV;PLAPHPLPP;PSLSQDAMTTLQ;RKYKEPQFRA;TEFDSVSE;VDEEVEEEEEEEEENEDR 14 9.2 1.003 -2.4307 6.62635 9.11502 0 6.33421 4.14462 10.1856 11.6331 0 0 6.09005 8.12153 4.337 6.67172 11.8986 7.9622 A0A8P0N6M8 A0A8P0N6M8_CANLF Laminin subunit beta 1 LAMB1 Canis lupus familiaris (Dog) (Canis familiaris) AGKLQSLD;CACNPLGTIPGGNP;CGGPGCGG;CHLQGSVSASCHPVTG;CLKCLYHTEGER;GACLSCQDYSTGHNCER;GVCDDCQHNTMGRNCEQ;GYYFTTLDHYIY;HCDGSDCQC;IIGSGDHC;PERDVRDP;QPCQCNGHAEDCDPG;SLDNTVKELAEQLE;SLSPGSRYV;TEQEHCDGSDCQ;TLLNASQRISELERNVEE;VTADMVKEALEEA 17 12.1 0.99697 -7.3564 7.48228 7.41676 0 9.9468 12.4619 8.88304 9.94612 7.25673 6.48057 0 0 8.31456 8.97991 0 0 A0A8P0N6N2 A0A8P0N6N2_CANLF Histidine rich calcium binding protein HRC Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; ossification [GO:0001503] calcium ion binding [GO:0005509] CDEENMGEHCDQ;CENCHCDEENMGEHCDQCQ;CENCHCDEENMGEHCDQCQHCQ;CGYCSFCNRCTECENCHCDE;CHCDEENMGEHCD;CHCDEENMGEHCDQCQHCQF;CTECENCHCDEE;CTECENCHCDEENMGEH;CTECENCHCDEENMGEHCDQ;EDDDDDDAMS;EEDDDDDDAMSTEYGH;EEDQGSHEEDDE;EEEEEEEDQGSHEEDDESSEW;EEGHGLSLSQEEEEEEEEE;EEQEEEEDDDDDDA;EHGHHFPNHRSH;ENCHCDEENM;ENCHCDEENMGEHCD;ENCHCDEENMGEHCDQ;EQEEEEDDDDDDAMS;EQEEEEDDDDDDAMSTEY;GSPAPSHRGREDENK;GYCSFCNRCTECENC;HCDEENMGEHCDQC;HLRERDSEEEEEEEDQGSHEEDDE;HQAHSHGGHRKEEDED;KDEDEVVSTE;NRCTECENCHCDEENMGEH;RCTECENCHCDEENMGEHCDQ;SFCNRCTECENCHCDEE;SPAPSHRGREDENK;TECENCHCD 32 18.4 1.0035 -1.6083 6.2775 8.37764 0 8.57156 8.33387 6.83618 9.74101 9.29623 0 6.49336 7.08746 0 9.9867 9.45339 7.36229 A0A8P0N6N4 A0A8P0N6N4_CANLF L-Fucosyltransferase (EC 2.4.1.-) LOC102151792 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi cisterna membrane [GO:0032580] galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107] DWMEEEYRHIPGEYV;SLSLSLSVTIINQ 2 6.3 0.9396 0.059836 0 0 0 0 0 0 0 8.7846 0 0 0 0 0 0 0 A0A8P0N6N8 A0A8P0N6N8_CANLF Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) LDAH Canis lupus familiaris (Dog) (Canis familiaris) lipid storage [GO:0019915] lipid droplet [GO:0005811] lipase activity [GO:0016298] EDIKKDFPEGDIRLC;LKPWPEKIKSFVIRIA;VLSKKLWDS 3 10.6 1.0015 -0.70109 0 5.2402 0 0 0 0 0 0 0 8.09682 0 0 9.04955 0 0 A0A8P0N6P7 A0A8P0N6P7_CANLF D-aspartate oxidase (EC 1.4.3.1) DDO Canis lupus familiaris (Dog) (Canis familiaris) D-amino acid catabolic process [GO:0019478] peroxisomal matrix [GO:0005782] D-aspartate oxidase activity [GO:0008445]; FAD binding [GO:0071949] RDIFSRCCALEPSLRGAAGL;RVRGAAGTLRVVHHYGHGGGGV 2 11.8 0.98631 -0.23191 0 0 0 0 0 0 0 0 0 4.44387 0 0 0 0 0 A0A8P0N6Q6 A0A8P0N6Q6_CANLF MEF2 activating motif and SAP domain containing transcriptional regulator MAMSTR Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DLLPESEYGTWRSLKESP 1 4.3 0.97393 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 6.40669 0 A0A8P0N6R0 A0A8P0N6R0_CANLF Glutamate receptor GRIN2D Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] postsynaptic membrane [GO:0045211] transmitter-gated monoatomic ion channel activity [GO:0022824] AGGGGSGAPGEPPLLPGGAP;DGVWNGMIGEVFYQRAD;FPFLIFFPSLFLPFI;FSRGMYSCCSAEAAP;FTIGKSIWLLW;GAGPPGGA;GASLGGLEPWWFA;LAGGGGSG;LHRYFMNITWDNRDYSFN;PPPSIGSACFSISCVSMSLGGRGV 10 8.8 1.0023 -1.36 0 0 0 9.65258 8.90391 0 8.38539 12.8525 0 8.96443 7.47541 9.82126 0 0 0 A0A8P0N6R2 A0A8P0N6R2_CANLF DENN domain containing 2A DENND2A Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] ETYQDSPPRRSFLESLN;KKKKIPKLV;KKKKIPKLVLRINAI;LCRPLDSRLEHVDFE;LNNLMLESKVDCFQ;NKGVMKVGGQDAEP;PQNGRKKKKIPKLVLRINAIYEAR;RKKKKIPKLVL;TLSGIYSLECRPQI;VYEDIVDP 10 8.9 1.0026 -1.7819 0 8.94661 3.54325 0 0 4.7026 0 9.34481 10.4801 9.87331 0 8.12794 9.56875 0 0 A0A8P0N6R8 A0A8P0N6R8_CANLF WD repeat and coiled-coil-containing protein WDCP Canis lupus familiaris (Dog) (Canis familiaris) KSSPVYPPSQDLP;LAVQHKNHVI;LVWTDGNQ;QDLPYVHITYQHVHL;VVASGSSL 5 7.3 0.95052 0.053889 0 0 0 0 0 0 7.12939 0 0 0 0 0 0 0 0 A0A8P0N6S8 A0A8P0N6S8_CANLF Zinc finger SWIM-type containing 9 ZSWIM9 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AKVKLVFVEDQ;EGADSEGP;GVTCSTPVGTALEGDPE;HVEKERGRGLQSGDWGG 4 5.7 0.98945 -0.26566 0 0 0 0 0 7.23888 0 0 0 0 0 0 0 0 0 A0A8P0N6S9 A0A8P0N6S9_CANLF Family with sequence similarity 83 member E FAM83E Canis lupus familiaris (Dog) (Canis familiaris) DTPAKALMRQ 1 2 0.99892 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 8.72421 0 A0A8P0N6T3 A0A8P0N6T3_CANLF PHD finger protein 10 PHF10 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] npBAF complex [GO:0071564] metal ion binding [GO:0046872] AAAAAAAAGTRRRRR;DEVIDLMIKEY;GTRRRRRRRRRRGALGL;LIEYKWPPDETG;PALDSDGDSDDAED;SSRSCETSSQD 6 13 1.003 -0.78732 0 0 0 0 0 6.57764 0 7.15937 0 0 0 0 0 0 6.42385 A0A8P0N6T6 A0A8P0N6T6_CANLF Outer dynein arm docking complex subunit 1 ODAD1 Canis lupus familiaris (Dog) (Canis familiaris) ESHSGAES;PLWTRCLWNTLQG 2 3.4 1.0031 -1.0316 0 0 0 0 0 0 0 0 0 0 6.08996 7.81852 0 0 0 A0A8P0N6T7 A0A8P0N6T7_CANLF Ribosome production factor 2 homolog (Ribosome biogenesis protein RPF2 homolog) RPF2 GTF3C6 Canis lupus familiaris (Dog) (Canis familiaris) maturation of LSU-rRNA [GO:0000470]; ribosomal large subunit assembly [GO:0000027] nucleolus [GO:0005730] rRNA binding [GO:0019843] DRVVKPKTKRAKRFLEK;SGCRTPRIELEEMGLSLDL;TFGTTYGRI 3 15.1 1.0013 -0.7081 0 0 0 0 0 0 9.1213 3.89501 0 0 9.10258 0 0 9.02625 0 A0A8P0N6X0 A0A8P0N6X0_CANLF Cytochrome P450 family 4 subfamily X member 1 CYP4X1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" LMTLDVLMKCAFSQ;LYSFLHHHDIIF;TTFEASKINFYRLYSFLHHHDIIF;VEKYPCAFPYWV 4 9.9 0.99647 -0.11335 0 0 0 7.09571 0 9.55641 10.4611 11.0198 0 0 0 0 0 8.12081 0 A0A8P0N6X3 A0A8P0N6X3_CANLF Epididymal sperm binding protein 1 ELSPBP1 Canis lupus familiaris (Dog) (Canis familiaris) single fertilization [GO:0007338] extracellular region [GO:0005576] KLWCPTTENMDEDGKW 1 7.2 0.95533 0.049233 0 0 0 0 0 0 0 0 0 0 10.3476 0 0 0 0 A0A8P0N6X5 A0A8P0N6X5_CANLF "Eukaryotic elongation factor, selenocysteine-tRNA specific" EEFSEC Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] DRLGICVTQFDPKLLERGLVC;LLTSQISI 2 4.8 0.99239 -0.18048 0 0 0 5.35533 0 0 0 0 0 0 0 0 0 0 10.3505 A0A8P0N6Y0 A0A8P0N6Y0_CANLF Selenoprotein W SELENOW Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DSYKSKYLQLKKKLEDE 1 19.5 0.97639 0.046227 0 0 0 7.0706 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N6Y2 A0A8P0N6Y2_CANLF Prestin (Solute carrier family 26 member 5) SLC26A5 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transmembrane transport [GO:0098661]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] DLVSGISTGVLQLPQ;EVKYPPIVIKSTFPEE;IVNLKGMFMQFSDLPFF 3 6.8 0.8518 0.14937 0 0 0 0 0 0 7.29205 0 7.71747 4.83552 0 0 0 9.0316 0 A0A8P0N6Y9 A0A8P0N6Y9_CANLF EH domain containing 2 EHD2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525] EISDEFSE;EQEVPGSRVGPE;LFELEEQDLFRDIQ 3 6.3 0.98556 -0.44355 0 8.83403 0 0 0 0 0 0 0 0 0 0 9.62207 0 0 A0A8P0N6Z1 A0A8P0N6Z1_CANLF V-set and transmembrane domain containing 5 VSTM5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CHGVPTIEWRYTSSWG;HVSEILYEDLH 2 13.5 0.94724 0.084724 0 0 5.59956 0 0 0 0 0 0 0 0 0 0 8.94448 0 A0A8P0N6Z6 A0A8P0N6Z6_CANLF Pyroglutamylated RFamide peptide receptor QRFPR Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] TEILTMTCIA;VVALFAVCW 2 4.6 0.99265 -0.55385 0 0 0 0 0 0 0 9.34018 0 0 0 0 0 0 0 A0A8P0N6Z9 A0A8P0N6Z9_CANLF Glutamate dehydrogenase Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520] "nucleotide binding [GO:0000166]; oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [GO:0016639]" FTMELAKKG;SGLAYTMEHSARQIMRTAMKYNLG 2 6.7 0.9906 -0.5385 0 10.3098 0 0 0 0 12.0583 0 0 0 0 0 0 0 0 A0A8P0N706 A0A8P0N706_CANLF "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog)" ALG11 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [GO:0004377]" AKLLNKKVAEPLPSLKLVLI;FVILWGIRLLLQKKK;HLVGGGGG;SKLKLIYYYLFAFIY;YCNAGGGG 5 7.9 1.0014 -2.6778 4.87046 5.90145 3.81957 0 0 0 0 9.1485 0 0 0 0 0 0 8.75902 A0A8P0N718 A0A8P0N718_CANLF RAD54 like RAD54L Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] IVNRCLIRRT;LVHFVNSGILGTAH 2 3.2 0.98628 -0.41465 14.8549 0 0 14.3836 11.7189 0 15.4185 0 0 12.5327 0 0 0 0 0 A0A8P0N733 A0A8P0N733_CANLF ISY1 splicing factor homolog ISY1 Canis lupus familiaris (Dog) (Canis familiaris) generation of catalytic spliceosome for second transesterification step [GO:0000350] nucleus [GO:0005634] YASETLQAQSEEAKRL 1 5.7 0.99428 -0.025314 0 12.9807 12.7672 0 12.8809 0 0 0 0 0 0 0 0 0 0 A0A8P0N745 A0A8P0N745_CANLF FAM124 domain-containing protein FAM124A Canis lupus familiaris (Dog) (Canis familiaris) CSQDFFSLGPG;SLPWSFQRSKSLFCL;WAPGGCTA 3 6.4 1.0026 -0.75937 0 10.701 10.2637 0 0 0 0 0 0 10.321 0 10.6245 11.0515 11.167 0 A0A8P0N752 A0A8P0N752_CANLF Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) DRC1 Canis lupus familiaris (Dog) (Canis familiaris) axonemal dynein complex assembly [GO:0070286] axonemal dynein complex [GO:0005858]; motile cilium [GO:0031514] EYLMNRIKKVEDYEKQLNKQRI;RIAARLEARRREAL 2 5 0.92962 0.10747 0 4.31976 0 0 0 0 0 0 8.72561 0 0 0 0 0 0 A0A8P0N762 A0A8P0N762_CANLF Coatomer subunit gamma COPG1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] LNVLEQKQKALN;TDHMVFQFDCTNTLND;TTGETDDEGYEDEY;VLEDLEIT 4 6.2 1.0016 -0.74452 0 0 0 9.8908 0 0 8.02042 12.6283 0 0 0 0 0 12.2685 0 A0A8P0N771 A0A8P0N771_CANLF Frizzled-4 FZD4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] Wnt receptor activity [GO:0042813] DLSLRRLRLLLLLLLLL;DLSLRRLRLLLLLLLLLL;GEECHSVGTNSDQY;GGVDLSLRRLRLLLLLLLLLL;GVDLSLRRLRLLLLLLLLL;LLLLLLLE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;RLLLLLLL;RLLLLLLLL;RRLRLLLLLLLLLLE;RRLRLLLLLLLLLLEPA;SLRRLRLLLLLLLLL;SLRRLRLLLLLLLLLL;SLRRLRLLLLLLLLLLEPAR;SVPGAPGGVDLSLRRLRLLLLLLLL;VDLSLRRLRLLLLL;VDLSLRRLRLLLLLL;VDLSLRRLRLLLLLLLLLL 20 8.5 0.85185 0.14831 0 0 0 0 0 0 0 0 0 6.06712 6.65793 0 0 0 0 A0A8P0N773 A0A8P0N773_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) PPM1N Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine/threonine phosphatase activity [GO:0004722] IAEVYSQLYQ;LCAQLLDTCLCKG 2 5.7 0.99185 -0.18212 11.3331 0 0 0 0 0 0 8.73488 0 0 0 0 0 0 0 A0A8P0N794 A0A8P0N794_CANLF Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) PPP1R37 Canis lupus familiaris (Dog) (Canis familiaris) DLRNNHVLDSGL;DSDSDSDSEEEEEDDG;GARPDSDSDSDSEEEEEDDGEEEDG;RPDSDSDSDSEEEEEDDGEEEDGE;SDSDSDSEEEEEDDGE;TQKALLAEIQNGCKQ 6 7.6 0.67442 0.27965 6.56152 2.55056 6.12454 8.59876 0 9.28035 0 0 0 0 0 0 0 0 0 A0A8P0N7B1 A0A8P0N7B1_CANLF Nudix hydrolase 15 NUDT15 Canis lupus familiaris (Dog) (Canis familiaris) KEQGYNPFKEDLDHLVGYKGHHHL 1 14.5 0.99416 -0.28554 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9805 A0A8P0N7C3 A0A8P0N7C3_CANLF Elastin microfibril interfacer 1 EMILIN1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] AVQACGQLCSGAPG;DLADLGATK;ESEERFRGLE;GAPAPFVP;GQLCSGAPGEQDSQ;GQLEGLLQARGDE;RSFLRPRYRV;VGAASYPPRGYSL 8 8.1 1.002 -2.6243 0 4.9692 0 0 11.4773 0 0 10.9089 5.25475 9.39032 0 0 0 8.28323 6.29254 A0A8P0N7D1 A0A8P0N7D1_CANLF Contactin associated protein family member 5 CNTNAP5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAWRIGPLRCYGDRHF;CNCDADKDEW;EASYLHFPTFHAEFSA;HKLLHSVRARFVRF;LFHGEGQR;PYEGPFCKKEV 6 5.8 1.0021 -1.2402 0 0 0 0 6.22888 0 0 6.00497 0 0 0 10.2174 10.2021 9.67599 0 A0A8P0N7F0 A0A8P0N7F0_CANLF Transmembrane and ubiquitin-like domain-containing protein 1 TMUB1 Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] LEIGSLLLPLLLLLLL;LEIGSLLLPLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLPLLLLL;LLLPLLLLLL;PLLLLLLLLL;SEPGPSGLEIGSLLLPLLLLLLL;SLLLPLLLLL;SLLLPLLLLLL;SLLLPLLLLLLLL;SLLLPLLLLLLLLLW 12 8.8 0.99469 -0.15431 0 8.71428 0 0 0 0 0 0 0 0 0 0 0 0 3.30185 A0A8P0N7H0 A0A8P0N7H0_CANLF nitric-oxide synthase (NADPH) (EC 1.14.13.39) NOS3 Canis lupus familiaris (Dog) (Canis familiaris) nitric oxide biosynthetic process [GO:0006809] calmodulin binding [GO:0005516]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; nitric-oxide synthase activity [GO:0004517] IVYGAGAGQGPALENPLPPPS;QEMVNYVL;QQELESLSQDPRRYE;SKGLQPAP;VLCMDEYD;VLEVPLEHPTLE 6 5 0.99908 -3.0515 10.6168 0 0 11.1707 7.60681 7.23228 0 7.14129 0 0 0 0 8.83321 10.6649 0 A0A8P0N7I2 A0A8P0N7I2_CANLF Mitochondrial ribosomal protein S7 MRPS7 Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] VPILRGGHFYQE 1 6.7 0.9417 0.05044 0 0 0 0 0 0 8.7862 0 0 0 0 0 0 0 0 A0A8P0N7M4 A0A8P0N7M4_CANLF Integrin beta ITGB4 Canis lupus familiaris (Dog) (Canis familiaris) cell motility [GO:0048870]; cell-matrix adhesion [GO:0007160]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] ADGANVLAGIMS;EDQKGNIHLKPSFSDG;EHCSFRDEEDDCTYSYTV;HCSFRDEEDDCTYSYT;IPLLIFLLLLLALLLLL;IPLLIFLLLLLALLLLLC;LIPLLIFLLLLLALLLLLC;LLIFLLLLLALLL;LLIFLLLLLALLLLL;LVEAIDVPMGTATLGRRLVN;MGERLAQVLSQLTNDYTIGFG;PPFSFKNVISLTENLEEF;QRPGFATHTSSINPTELVPYG;TCIDSSGGICNGRGYCECGR;TGSFHIQRGEVGTYQVQ;WLIPLLIFLLLLLALLLL;YIPAEGDLLFQPGET 17 11.3 1.0028 -0.72893 11.292 5.79955 5.14258 0 0 8.94799 0 11.3061 0 8.94137 5.56111 11.4734 8.70086 6.80813 8.70726 A0A8P0N7N9 A0A8P0N7N9_CANLF Tripartite motif containing 65 TRIM65 TRIM47 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] GTEADAESQDPDSTNNVESEAP;LGEGALDRGTYYWEVEI;QEADQSKVLSAVEDRMD 3 7.5 0.98492 0.046227 0 0 0 0 0 0 0 0 0 0 0 6.86009 0 6.73742 0 A0A8P0N7P1 A0A8P0N7P1_CANLF Glycerophosphodiester phosphodiesterase domain containing 4 GDPD4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] phosphoric diester hydrolase activity [GO:0008081] DWVVFLGTGYWFFWSI;MLKANRVEPG;RTKRCNII;STPTKRFG;VLCTCNRQCY;YGLESDVHLSYDLVPF 6 13.2 1.0033 -1.5473 0 0 7.47037 0 8.28123 8.90424 6.16044 0 0 7.2738 0 0 10.8696 10.188 0 A0A8P0N7P6 A0A8P0N7P6_CANLF Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) EPB41L5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886] cytoskeletal protein binding [GO:0008092] EKCLNNAIESPG;LVDAVTSSVPTLAGE;PATNGSVLKDA;RYSGKTEYQTTKT;SSPLPSPRPNIDV;VKARDGND;VPIQTEEMELAIFEKWKEYR 7 12.6 1.003 -1.5396 7.36194 10.3933 0 0 0 0 0 7.32661 0 5.76903 7.98812 6.37855 0 0 0 A0A8P0N7P8 A0A8P0N7P8_CANLF SKI/SNO/DAC domain-containing protein DACH1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GGGGGGGG;GGGGGGSG;GGGNGGGG;IVQKRLKKEKK;IVQKRLKKEKKAKRKL;QKNRAIVQKRLKKEKKAKRKLQEAL 6 7 0.92342 0.12026 0 0 6.16577 6.06247 0 0 0 0 0 0 0 0 6.39775 0 0 A0A8P0N7P9 A0A8P0N7P9_CANLF Transporter SLC6A1 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] plasma membrane [GO:0005886] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] QPSEDIVRPENG;VGFMAHVTKRSIAD;VGLAAAVL 3 5.7 1.003 -1.6293 7.68587 9.24279 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N7Q0 A0A8P0N7Q0_CANLF Protein kinase AMP-activated non-catalytic subunit gamma 3 PRKAG3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] APILMALDIFVDR;QPSFLSRTIQ;TSSKLVIF;VLHILTHKRLLKFL 4 9.3 1.0035 -1.5954 8.64317 6.24812 0 0 6.50545 0 0 0 0 0 0 8.95134 0 0 0 A0A8P0N7S6 A0A8P0N7S6_CANLF Latent transforming growth factor beta binding protein 4 LTBP4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AAGSECEDVDECEN;ASCLDVDECSEEDLCQSGIC;CCRGAGLA;DVDECATGGRCQHGECAN;ECVDNDECA;EPPPCGPG;GRRPLLLVLLLP;LRGGECASPLPGL;PSGRRPLLLVLLLPL;PTGFLPTHRPEPPPEPRPG;SYHCTCEPPL;VYTMPLAN;YHAQRLECVDNDECADEEP 13 9.4 0.99918 -3.1738 7.87357 8.02708 0 10.3767 0 9.12624 9.50261 9.18589 10.4607 10.2857 0 8.23683 5.34721 0 0 A0A8P0N7S7 A0A8P0N7S7_CANLF NCK associated protein 5 NCKAP5 Canis lupus familiaris (Dog) (Canis familiaris) DYLPPPSSAKP;EALNELHIGSSDEKSPS;EEKVMLCIQENV;FVYDTDSHDDAD;PLERKLYPSVQP;SLDSSLVDADGEGENP;SRPKTFSFIKQQRVVKR;THEKGLKTRLPVGLKVLMKSP;TSEQLPEWGSE;VGLKVLMKSPQLLRKSST 10 6.9 1.0021 -0.64955 0 0 12.5596 0 9.50875 8.10915 0 0 0 4.57101 0 0 6.03496 0 0 A0A8P0N7T6 A0A8P0N7T6_CANLF CD79a molecule CD79A Canis lupus familiaris (Dog) (Canis familiaris) B cell receptor signaling pathway [GO:0050853] B cell receptor complex [GO:0019815] transmembrane signaling receptor activity [GO:0004888] GLQGTYQDVGSL 1 5.2 0.94602 0.05044 0 0 0 0 8.32594 0 0 0 0 0 0 0 0 0 0 A0A8P0N7T8 A0A8P0N7T8_CANLF Transmembrane protein 163 TMEM163 Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768]; synaptic vesicle membrane [GO:0030672] VGGVMGFSILLSAEVFKHNAA 1 7.9 0.94862 0.050031 0 0 0 7.25597 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N7U1 A0A8P0N7U1_CANLF "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155)" MGAT5B Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] Golgi membrane [GO:0000139] "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity [GO:0030144]" DNSFMGFVSEELNET;LCPRDGGWGLPQ;SEELNETEKQLIR;SLCFLMTSLGG;VGFQLIAFRLFVLG 5 7.9 0.99111 -0.18133 0 0 0 0 10.1351 0 0 0 9.85345 0 0 0 0 0 0 A0A8P0N7U6 A0A8P0N7U6_CANLF Myosin VIIA MYO7A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; myosin complex [GO:0016459]; plasma membrane bounded cell projection [GO:0120025] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AAISGQHSWIE;EVRAKPYTLEEFSYDYFRPPPKH;FCCCCCFKD;LEGLRKRSKYVV;LIYRVKLILYIYISAGKTLLLF;LSLGCSDLGCAAPHSG;MVILQQGDYV;NKPMNIISLIDEE;PGKDPMADS;SIFHYYQEL;TTVPGKDPMADSI;WRLFFRKEVFTPWHNP 12 7.3 1.002 -2.6005 4.66562 0 0 0 10.9816 11.2619 11.0578 6.10436 0 0 0 9.43127 0 11.4918 0 A0A8P0N7W1 A0A8P0N7W1_CANLF Speckle type BTB/POZ protein like SPOPL Canis lupus familiaris (Dog) (Canis familiaris) protein catabolic process [GO:0030163] nucleus [GO:0005634] DLGNLWENTR;MFEHEMEE;VLKSSTFSSSPSDKM 3 9.3 0.99364 -0.55756 0 0 0 9.007 0 4.79088 0 0 0 0 0 0 0 6.21593 5.46637 A0A8P0N7Y3 A0A8P0N7Y3_CANLF RNA binding motif protein 26 RBM26 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; RNA binding [GO:0003723] DADPSALAKYVLALV;EITKEEER;FFLILRNMVKLKIVRL;PPAPPSLFTAVF;SRYRENRSRDERKKD;TESWSEFHED;TSPKVMQPLV;VLPDTYDTDGYN 8 10.8 0.98737 -0.37061 0 0 0 0 0 10.2555 0 10.4737 0 0 0 4.44897 0 10.5097 10.034 A0A8P0N7Z0 A0A8P0N7Z0_CANLF RCR-type E3 ubiquitin transferase (EC 2.3.2.33) MYCBP2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] axon [GO:0030424] metal ion binding [GO:0046872] AGNCGDGG;ARDRGGNQYLRHEDEQVLL;ASRNKKILNKKKLKRKQKSKSKVK;CAVCGCCK;CGSGESGCAVCGCCK;DETIKKYVPNMNGYT;EKCEDGKTEATFEMSMHHPMKSKSP;ELDEKDEKSMMC;EVLEKMLVIVVLPV;FLLSLSSAAEPSILCYHP;FYGFKCFAI;GGICGCGSGESGCAVCGCCKA;ICGCGSGESGCAVCGCC;KIELKGPENTLR;KKLKRKQKSKSKVKTRS;LQGFGVCLD;MATAMDEDLEEE;NVLQGQQP;QQKQMPMCDNHDDGETA;RNKKILNKKKLKRKQ;SASVAQQR;SEIIIKLIKDMAAGHLS;TADQKKPRG;VELPITKSPKIVHFSV;VHPPTGEE 25 6.1 0.99682 -5.1233 10.6628 8.88917 12.8533 13.6681 13.6866 9.42685 12.4972 10.4484 6.59283 12.9276 0 4.31252 10.4467 8.50997 10.0067 A0A8P0N7Z9 A0A8P0N7Z9_CANLF SH2 domain containing 4A SH2D4A Canis lupus familiaris (Dog) (Canis familiaris) GGGQHGAP;KQILFFKMREEQIRRWKEREVA;LLAELSEEQKQILFF;PGSFLIRVSE;SGGGQHGA 5 11 1.0031 -2.4043 8.83105 8.75739 0 0 0 5.90038 0 0 0 0 0 0 8.8704 8.63241 0 A0A8P0N820 A0A8P0N820_CANLF Family with sequence similarity 83 member G FAM83G Canis lupus familiaris (Dog) (Canis familiaris) EDEDDDDY;EDEDDDDYVT;FYSEEQRLALEAL;LDGEEDEDDDDY;LDGEEDEDDDDYVTLSDQDS;PAVAGPYPWQVKGGP;SDEYFEVRGR 7 7.1 0.94828 0.054534 0 0 0 0 0 0 0 0 0 6.93003 0 0 0 0 0 A0A8P0N822 A0A8P0N822_CANLF Transmembrane channel-like protein TMC8 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] CWQRWQRRRRAVGRRLGE;PPSGQRILH 2 4.1 1.0027 -0.7559 0 0 9.62892 0 0 8.47293 0 0 0 0 0 0 0 0 6.97602 A0A8P0N833 A0A8P0N833_CANLF Calpain 13 CAPN13 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] GPLRDMQYIFSVP;INLNSIPS;YFSLNPGTYVVVISAYRE 3 5.8 0.10909 0.84817 0 9.83547 0 0 10.8894 10.7267 0 12.9 0 0 12.0763 11.8326 12.1331 0 9.3965 A0A8P0N836 A0A8P0N836_CANLF SLIT and NTRK like family member 6 SLITRK6 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606] membrane [GO:0016020] AGIVVLVLHR;DLEDNPWDCSCD;DTFHGLENL;LSVLILGLLIVFIT;LTMLHTNDFSGL;LVLHRRRRYKKKQT;VEQTKNEYFEL;VEYFTLEMLH 8 10.9 1.004 -1.9856 8.48228 0 0 7.2074 0 0 0 7.92351 3.71348 10.7373 0 5.99041 0 0 0 A0A8P0N839 A0A8P0N839_CANLF Methyltransferase like 17 METTL17 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] GFVFAPCP;MDARDLVLKGKEKS;TARQHGRDLYRCAR;VPVEPEELQRR 4 10.1 1.0031 -1.5924 0 0 0 0 0 6.7003 11.2665 0 0 0 0 0 7.84568 0 0 A0A8P0N845 A0A8P0N845_CANLF KLF transcription factor 6 KLF6 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] GCRKVYTKSSHLKAHQRTH;QIVHETGYFSALPSLE;REPSHLWGCVP;SDSSEELSPTTKFTSDP 4 26.6 0.9895 -0.20344 0 0 9.43089 8.05994 0 0 0 0 13.4331 0 0 0 11.0847 11.6883 0 A0A8P0N848 A0A8P0N848_CANLF C-X9-C motif containing 1 CMC1 Canis lupus familiaris (Dog) (Canis familiaris) APSRSFPRRS;QERGRRLRRLRRLLRLPREAPG;RLRRLRRLLRLPREAPGRRACRPLR;RRLRRLRRLLRLPRE 4 15.8 0.98828 -0.22593 0 0 0 0 0 5.35004 6.81686 14.8379 0 0 0 0 0 6.91791 0 A0A8P0N859 A0A8P0N859_CANLF 5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) PLD3 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal lumen [GO:0043202] nuclease activity [GO:0004518] EPSMRAFLLSLA 1 2.5 0.95299 0.05044 0 0 0 0 0 0 0 0 9.05346 0 0 0 0 0 0 A0A8P0N868 A0A8P0N868_CANLF "Presequence protease, mitochondrial (Pitrilysin metalloproteinase 1)" PITRM1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872] IEKGFKEDQ;KDKQQIYE;TTVGVSFLLPDI;TYSVISGGDPM;YTLYPFST 5 4.6 1.0033 -2.3327 0 0 9.88531 0 5.36657 9.58598 0 0 0 0 0 0 0 8.91379 0 A0A8P0N873 A0A8P0N873_CANLF WD repeat-containing protein 37 WDR37 Canis lupus familiaris (Dog) (Canis familiaris) CQLVKEYIGHRDGIW;DTTICGEDEVECSDKDE 2 6.5 0.98459 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.37721 A0A8P0N878 A0A8P0N878_CANLF Coiled-coil domain containing 40 CCDC40 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082] DLAYSEVGGWEE;EEEPVEEPIIVGE;EKKIQLAKEMRASVDSETGQTEL;IVEKLQEHMTSNKMTK;LSEEEPVE;MDASIVEKLQEHMT;QDDDEAVGAAELSEEEITAF;QLTTKANQLQ;VTEKEFVRSL 9 9.6 1.0027 -1.1953 9.02117 11.6024 13.2572 8.11588 6.95664 0 8.57577 9.68038 13.8149 0 0 0 10.8717 8.17233 0 A0A8P0N897 A0A8P0N897_CANLF Ras and Rab interactor like RINL Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] DEENEPEDVLTHH;GAGPPGAQGAGLAGQGPA;PGAQGAGLAGQGPAPA;QDAEALLELWPPGSF;VEETEKEDKDENEDENEADFRDEEN;VSLSFEEP 6 13.4 1.0028 -1.5845 0 0 11.3187 9.21126 10.3597 9.54525 0 0 9.91864 0 0 0 0 0 0 A0A8P0N8B2 A0A8P0N8B2_CANLF mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (EC 3.2.1.96) ENGASE Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925] DCLLRDLFVSFA;LEGASNVGVALELT;LIAQFFRF;QDELNQHNR;QEEAEGPW 5 7.4 0.99884 -3.2663 2.79668 0 8.83007 0 0 8.27701 0 9.09091 0 0 8.91438 0 0 0 9.75907 A0A8P0N8B7 A0A8P0N8B7_CANLF Cytohesin 1 CYTH1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] guanyl-nucleotide exchange factor activity [GO:0005085] AFAQRYCQCNNGV;EVANEIENLGST;MEAFAQRYCQCNNGVF;RRRKQELLADIQRLKDE;THTFFNPDREGWLLK 5 15.1 0.98777 -0.33923 0 0 0 8.52415 0 0 0 0 0 13.9727 13.9481 7.97154 0 3.95996 2.54129 A0A8P0N8C8 A0A8P0N8C8_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAD18) RAD18 Canis lupus familiaris (Dog) (Canis familiaris) postreplication repair [GO:0006301]; protein monoubiquitination [GO:0006513] nucleus [GO:0005634] metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630] EASHKNDL;EVEETIDDLL 2 3.8 1.0024 -1.3996 0 0 0 0 0 0 0 0 0 0 0 7.56506 7.20653 0 0 A0A8P0N8E2 A0A8P0N8E2_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC17 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659] palmitoyltransferase activity [GO:0016409] DLNIDSWLIKGLM;ELAETGSLDLSI;ITQIATCSPWMFWM;LATKFWMYVTWFFWFWNAHLNFLFI;VPLLHPEEIKPQS 5 12.2 0.54497 0.42488 0 0 0 11.2363 5.40518 0 0 11.0174 9.06907 0 0 0 0 0 0 A0A8P0N8G6 A0A8P0N8G6_CANLF BAH domain and coiled-coil containing 1 BAHCC1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin binding [GO:0003682] DDNGSFEEEEEEEEEEEEAEEEPAA;EVEMRVRLAE;HHAVAYTVPSG;KAPFVGLG;LVEAAGLDSPS;PGEAAAPSLSPKAHDSP;PGTSPLDP;QQQRAGPVQRKPEDHHP;SLSPKAHDSPE;YLDPFSGS 10 4.4 0.98377 -0.25675 0 0 0 0 0 0 0 0 0 0 0 0 0 9.39842 0 A0A8P0N8G8 A0A8P0N8G8_CANLF C2H2-type domain-containing protein ZIC2 Canis lupus familiaris (Dog) (Canis familiaris) AAGAAAAGRAAGAAAAPAGAA;SSPAASSGYE;THPSSLRKHMK 3 7.5 0.98921 -0.20317 0 0 0 0 0 9.60844 0 0 0 0 0 0 0 0 0 A0A8P0N8I4 A0A8P0N8I4_CANLF Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl aminopeptidase) TPP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240] ATKLVEEKPTKENWKNCIQ;AYRSHEFYKFC;DLAPCITLKSWVQT;LGSRDVLPNNRQL;NGVAPGAQ;NWLPIITNS;PEEPERNGVAPGA;PHQYSLKL;QLYEMILTYNF;SEVSAKFVL;TEALRDLKIQWMTKLDSSDIYNE;VEEKPTKENWKNCIQLM;VGAYVSPD 13 11.1 0.99894 -3.2559 9.20398 0 0 0 8.14476 0 12.7236 0 11.2709 0 8.94834 8.45894 0 10.0123 9.89125 A0A8P0N8K5 A0A8P0N8K5_CANLF Collagen type VI alpha 5 chain COL6A5 Canis lupus familiaris (Dog) (Canis familiaris) DIYLPLQEKMCTN;DLRKAILNIEQLQGNTHT;EFDLITYNSIYQMKH;FFCDGSDMVSNSEFATMTTF;GAPGLYGS;GVRIISVGLQSASE;KILLIIFVLIL;LKGTRGHRGEDGDPGRRGDIGPTG;LSIIKKDRKHRISEI;LVDESVGTRQDL;SIGSDKVQ;SPNPENVG;VGSPGPPG;VGTPNLRKNKVIFVI 14 7.3 0.99889 -3.1484 7.64386 8.99215 6.48911 0 9.29124 0 9.80258 6.80967 8.27193 0 0 7.84981 0 9.36148 10.0388 A0A8P0N8K9 A0A8P0N8K9_CANLF Dihydrouridine synthase 1 like DUS1L Canis lupus familiaris (Dog) (Canis familiaris) AEGRARGGWLPLT 1 2.6 0.99098 -0.269 0 0 0 0 0 0 0 0 0 0 0 0 10.1024 0 0 A0A8P0N8L8 A0A8P0N8L8_CANLF NHL repeat containing 3 NHLRC3 Canis lupus familiaris (Dog) (Canis familiaris) KYNSFGDL 1 2.4 1.0041 -1.1044 0 0 10.6962 0 0 0 0 0 0 0 7.83586 0 0 0 0 A0A8P0N8M4 A0A8P0N8M4_CANLF Centrosomal protein 290 CEP290 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EDLKYNYKEEVKKNI;FEEIEDLKYNY;GERKFDFTSL;IAKRQVEILKAQQQSREKE;IVHQTDNVMDQLKKEND;LIEELQKKIKKL;LTEFRNSKS;MYEHVRTSLKQVEERNF;NKQSLIEELQKKIKK;QAKFGKCPGKVYHNLAQQ;SLSDNLND;VQELTDLLKAKNEEDDPVMAAVNAK 12 6.4 0.97953 0.048313 0 0 0 0 0 0 0 9.43452 0 0 0 0 0 0 0 A0A8P0N8S4 A0A8P0N8S4_CANLF Ras association domain family member 2 RASSF2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] IKFEMPVLKSFIQKLQ;YVVHTSGEKQ 2 8.6 0.98777 -0.48388 0 0 0 0 0 0 10.3829 12.8946 0 0 0 0 0 0 0 A0A8P0N8S5 A0A8P0N8S5_CANLF GDNF family receptor alpha 4 GFRA4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] FSRGPPALTHALLF;LLLLLLLL;PALTHALLF;QDPEHPLLQ 4 11.3 0.98622 -0.42609 10.6579 9.70266 0 0 0 0 9.93602 0 0 0 0 0 9.80798 0 0 A0A8P0N8T7 A0A8P0N8T7_CANLF "Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial)" MRPL3 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LGLPPKQKVKIFHV;VWRINTKNNIIY 2 8.2 0.98396 -0.25526 0 0 0 0 0 0 0 6.04747 0 0 0 0 0 0 0 A0A8P0N8U4 A0A8P0N8U4_CANLF Piccolo presynaptic cytomatrix protein PCLO Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; organelle [GO:0043226]; presynaptic active zone [GO:0048786] metal ion binding [GO:0046872] ATPHPGPAKPS;DLVKTQVPTAEGKPAG;DSKSSAAEPQKAVLAP;DYIYESLVEDTYNGS;HLDDAGAAIAAAEA;HYYHADTGYRHFPKSEKYSI;IDLRTVPKGEVQ;ILTYSEPS;IVPEEDKQQQ;MVQKKLEELQSMK;PQQSSPKKDPIP;QQEEERQAQFMMR;QQLELHEPPRAVDKAKS;RRERPKTPPSNLSPIEDA;SLDGDAGRRHSW;SQFIPPQTQ;SSVPISVPSEPLALDKHQP;TNHRPAESSVSTGSS;VPTAEGKPAG;VQSPSKPP 20 5 0.99893 -2.9622 0 11.5585 10.5143 0 0 10.0588 11.1373 0 11.0302 5.81216 6.88191 12.9405 11.8833 13.1795 8.98388 A0A8P0N8V7 A0A8P0N8V7_CANLF Nucleolar complex associated 4 homolog NOC4L Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nuclear membrane [GO:0031965] AAGRHGAG;LGHELDSDPFDPEEGNPAE;QESVPLQFIPAQGLLGLQDDLCA;SEDSEEIREAVRAC 4 9.7 0.99002 -0.26592 0 0 0 0 0 0 0 0 0 0 0 8.48913 0 0 0 A0A8P0N8W8 A0A8P0N8W8_CANLF Cell adhesion molecule L1 like CHL1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] INDTYELGEL;KPITEESSTLGEGKYAGLYDDIS;VNGSPIDKNPFAGDVVSP 3 4.6 0.99347 -0.045263 0 0 9.87374 0 7.89555 8.23568 0 0 0 0 11.1896 0 0 0 9.89385 A0A8P0N8X0 A0A8P0N8X0_CANLF Atypical chemokine receptor 4 ACKR4 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] membrane [GO:0016020] chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; scavenger receptor activity [GO:0005044] ITESIALFHSCLNP;RLCQVIDIIYSLITDCDMSKR 2 10 0.88257 0.13172 0 6.79468 0 0 0 0 9.3965 0 0 0 0 0 0 0 0 A0A8P0N8X9 A0A8P0N8X9_CANLF E1A binding protein p400 EP400 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229] EEEEEEEEEEEEEK;NDLDLEEEEEEEEEEEEEE;QHLQGNMMDFLAFKKKHYAPLQAY;VLSGALWLFE;YQVQQLMNRSPVTGQNVNIALQ 5 11.8 0.99818 -0.61146 0 0 0 0 0 0 0 0 9.42773 0 0 0 0 0 0 A0A8P0N900 A0A8P0N900_CANLF Interferon-induced transmembrane protein 3 LOC483397 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCLGIVAFAYSVKARDRKMVGDLTG;VGIILGIISIVLLR;VGIILGIISIVLLRI;VGIILGIISIVLLRIA;YWALLQAMPRRTMDMM 5 28.2 0.99492 -0.083294 3.75542 4.20797 0 0 8.53403 0 0 0 12.0439 0 0 0 0 0 8.01859 A0A8P0N936 A0A8P0N936_CANLF Integrin subunit alpha 5 ITGA5 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EAEYSGLVRNPGNFSSL;GARGPRGRPAPP;GVPLWIIILA;GVPLWIIILAILVG;GVPLWIIILAILVGLLLL;LAILVGLLLLGLLIYILYKLGF;LLLLGLLIYILYKL;LLLLLLLP;LPLLPLLLLLLLPPPPRAA;PRGRPAPPLPLLPLLLLLLL;VLSGPPRSFFGFAVDFYR 11 9.1 1.0026 -0.87879 0 8.79747 7.94568 6.27975 10.698 0 0 10.3414 0 6.04791 6.6575 7.81397 8.14338 12.3801 8.71215 A0A8P0N942 A0A8P0N942_CANLF Kirre like nephrin family adhesion molecule 2 KIRREL2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVRIPGSSDGSSSRGP;QLHVLVPPEAP;VHTDHSDLVLDEEGALETKDP 3 8.2 0.99233 -0.19215 0 0 0 3.1239 0 0 0 0 0 0 0 0 4.97159 0 8.97602 A0A8P0N959 A0A8P0N959_CANLF Mitochondrial S-adenosylmethionine carrier protein (Solute carrier family 25 member 26) SLC25A26 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] ITYEYVKWFLHTD;VLREALWSWR;WRQDHVVDCWQS 3 9.9 0.99547 -0.565 0 0 0 0 0 0 0 0 0 0 8.4939 0 0 0 0 A0A8P0N967 A0A8P0N967_CANLF Transglutaminase 6 TGM6 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] ARRDLGPSYNGWQV;NDPATDVSHRHDPI;PQEKASVQFSI 3 5.5 1.0037 -0.81224 0 0 0 0 0 0 12.8461 0 0 0 0 0 0 0 0 A0A8P0N972 A0A8P0N972_CANLF NADH-cytochrome b5 reductase (EC 1.6.2.2) CYB5R2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]" MFGVSLRDPSL;RDPSLLLAITVIGVTVVLLALR;YTLDRPPVGWKYSSGYIT 3 15.1 0.98743 -0.40354 9.09329 0 0 0 0 7.61368 0 0 0 0 0 0 4.8126 0 0 A0A8P0N999 A0A8P0N999_CANLF Amino acid transporter SLC1A2 Canis lupus familiaris (Dog) (Canis familiaris) L-alpha-amino acid transmembrane transport [GO:1902475] membrane [GO:0016020] symporter activity [GO:0015293] GLSLHMTLRT;IAQMNGVI;KQLGPGKKNDEVSSLDAF;LVIMIMWYSPLGI;MIMWYSPLGIACLICGK;RQLGMYMITVIVGLII;VEFFNILNEIVM;VILVLAIHPG 8 15.8 1.003 -2.4148 0 0 0 7.85137 9.35661 7.31461 5.94392 0 0 0 0 0 0 6.97659 0 A0A8P0N9A0 A0A8P0N9A0_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] DKNGFSLGFS;MFVWSYWKTIFTLPMNPS 2 7.8 0.97747 0.048313 0 0 0 0 0 0 0 0 0 9.94835 0 0 0 0 0 A0A8P0N9A7 A0A8P0N9A7_CANLF "PEAK1 related, kinase-activating pseudokinase 1" PRAG1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EDKPMFSYQEL;IYAESTKRKKA;LSLTSEAASSSDG;PPVSSATPSAPAT;PVSSATPSAPATA;SGHWVPAPG;SQVIWRRA;VELEDWLCCQY 8 5.4 1.0019 -1.8171 0 9.09286 0 7.62388 0 0 9.89362 0 0 0 9.66789 10.8694 8.87375 13.2328 0 A0A8P0N9A8 A0A8P0N9A8_CANLF Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4) LRFN3 Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734] LPLLARPRGSPASALVL;TEHGATAA 2 4 1.0036 -1.0582 0 0 0 0 0 10.037 0 0 0 0 0 0 0 0 5.87059 A0A8P0N9B3 A0A8P0N9B3_CANLF Transferrin-like domain-containing protein INHCA Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] CSATTNTMETHPCL;FPSVSVEEATAEMAQ;HYDLLCLDNSRKSV 3 6 0.93343 0.060769 0 0 0 0 0 0 0 0 0 4.03131 0 0 0 0 0 A0A8P0N9C8 A0A8P0N9C8_CANLF NLR family pyrin domain containing 10 NLRP10 Canis lupus familiaris (Dog) (Canis familiaris) ETSSNFELKFSL;LEPVDQLSHICLNDYREIYREHV;TLARKMVLDWATGTLYPGRFDYVFY;VLDQLLFWC;VLEQELDSVLVE 5 11.8 0.98803 -0.49551 0 7.39111 0 0 0 8.10208 0 9.88536 14.1668 8.90728 0 0 0 0 0 A0A8P0N9E7 A0A8P0N9E7_CANLF Chromosome 16 C8orf48 homolog C16H8orf48 Canis lupus familiaris (Dog) (Canis familiaris) ESTRVPDEE;FITKWIRYLRGQETSS 2 7.6 0.98946 -0.19886 0 0 0 0 0 0 9.59625 0 0 0 0 0 0 8.98641 0 A0A8P0N9I9 A0A8P0N9I9_CANLF TNF receptor superfamily member 19 TNFRSF19 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] membrane [GO:0016020] signaling receptor activity [GO:0038023] SSQDLVGGALP 1 2.7 0.98934 -0.26153 0 0 0 0 0 0 0 0 0 8.46451 0 0 0 0 0 A0A8P0N9J4 A0A8P0N9J4_CANLF Rhombotin-2 (LIM domain only protein 2) LMO2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DRYFLKAIDQYWHE;IDQYWHEDCLSC;WHEDCLSCDLCGC;YWHEDCLSCDLCG 4 13.6 0.99366 -0.076045 0 0 7.49297 0 0 0 0 0 0 0 0 0 5.50236 7.16601 6.73917 A0A8P0N9L4 A0A8P0N9L4_CANLF IRF tryptophan pentad repeat domain-containing protein LOC609817 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] EPPPGARVLRHLLRHLERGVL;GVLLWVAPE 2 6.1 1.0025 -0.75436 0 0 0 0 6.99853 0 0 0 0 0 0 6.03631 0 0 0 A0A8P0N9P4 A0A8P0N9P4_CANLF Keratin 80 KRT80 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] ERAACAAGFGSSL;ETRWRFLQGQDSGTF;IVEEVKVQYD;LVPLDLKVDPA;QEELRKVSQERGQ;QGGHAGPG;SVVQSRSRP 7 14.4 0.99002 -0.26592 0 9.77487 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0N9R8 A0A8P0N9R8_CANLF Nucleophosmin Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] AADEDDDDDDDD;AADEDDDDDDDDHDDDEDDDD;ADEDDDDDDDDH;ADEDDDDDDDDHD;ADEDDDDDDDDHDDD;ADEDDDDDDDDHDDDE;ADEDDDDDDDDHDDDED;ADEDDDDDDDDHDDDEDDDD;ADEDDDDDDDDHDDDEDDDDDDF;DDDDDDDHDDDEDDDDDD;DDDDDDHDDDEDDDDDDFDD;DDDDHDDDEDDDDDDFDDEEA;DDDHDDDEDDDDDD;DDDHDDDEDDDDDDFDD;DDDHDDDEDDDDDDFDDEE;DDEDDDDD;DDHDDDEDDDDDDFDDEE;DEDDDDDD;DEDDDDDDDDHD;DHDDDEDDDDDD;DHDDDEDDDDDDFDDEEAE;DHDDDEDDDDDDFDDEEAEE;DHDDDEDDDDDDFDDEEAEEKA;EDDDDDDD;EDDDDDDDDHDDDEDD;EDDDDDDDDHDDDEDDD;EDDDDDDFDDEEAE;ELHIVEAE;HDDDEDDDDDDFDDEEAE;KLAADEDDDDDDDDHDDDEDDDDDD;LAADEDDDDDDDDHDDDEDD 31 16.7 0.85791 0.16878 10.5934 7.06878 10.6221 9.06542 5.66491 8.92638 0 7.3156 8.63525 9.60796 0 3.56523 11.3665 0 11.519 A0A8P0N9S7 A0A8P0N9S7_CANLF Large tumor suppressor kinase 2 LATS2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DFSSDIRKQPAP;LENSDMVDQTEGCQ;TFRRFFDDNGYPF;TSPVPVRK;YHIGSFIFY 5 5.5 1.0031 -2.3433 0 0 0 0 0 0 7.45845 11.3209 9.62547 0 0 9.4732 0 0 7.88777 A0A8P0N9V1 A0A8P0N9V1_CANLF CFAP20 domain containing CFAP20DC Canis lupus familiaris (Dog) (Canis familiaris) ESEDDFYGGDSSEEERREG;LPRENKQILGLIQRFLVLQIYIPL;LYDPCLNCYFDPQ 3 8.3 0.95252 0.04941 0 0 0 0 0 0 0 0 0 0 0 8.71538 0 0 0 A0A8P0N9V7 A0A8P0N9V7_CANLF CBFA2/RUNX1 partner transcriptional co-repressor 2 CBFA2T2 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] DHRLTEREWADEWK 1 2.4 0.93929 0.060769 0 0 0 0 0 0 0 9.44564 0 0 0 0 0 0 0 A0A8P0N9X6 A0A8P0N9X6_CANLF DEP domain-containing protein 7 DEPDC7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] DSLLQQREVSTV;INDIWQEET;LLGQFYKCHPDIFIE 3 7.1 0.98932 -0.22378 0 0 0 0 0 0 0 9.89242 0 0 0 0 0 9.80452 0 A0A8P0N9Y2 A0A8P0N9Y2_CANLF Zinc finger protein 536 ZNF536 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DSEASGNFEDPTAVKAGCSA;EDDARKNRKYPCPLCGKRFRFN;EKAHITAESAQGQG;HKRDRKGD;PLEGSRDFLSHGL;SQKLHQITS;VHLRIHTGHRPFQC;VLNGQYAMSQKLHQIT 8 12.6 0.99069 -0.21107 0 0 0 0 0 8.56948 0 0 0 0 0 0 0 0 0 A0A8P0N9Y4 A0A8P0N9Y4_CANLF Carboxypeptidase A6 CPA6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AGDKVIRLIPNTEE;ASTTLYVS 2 5 0.98986 -0.19859 0 9.74157 11.0536 10.0386 9.99647 0 0 0 9.8616 9.57664 0 0 10.2864 10.1741 10.3113 A0A8P0N9Y9 A0A8P0N9Y9_CANLF Solute carrier organic anion transporter family member SLCO4C1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] EFEEGPCGCGDLQPR;LSNYLYVFILGQ;LYYCLLALTQGVVV;SPCFAGCANSTSK;TIFFNGFAVFLYKP;TVSILRCVH 6 11 1.0029 -0.78582 10.6068 10.7636 3.05759 3.38902 0 0 9.21485 8.67221 0 0 0 0 0 0 0 A0A8P0NA07 A0A8P0NA07_CANLF Tripartite motif containing 42 TRIM42 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CCCSWANDPNCKCCCTTSSNLQ;CCHCTCSENPNCHWCCC;CCHCTCSENPNCHWCCCS;CHWCCCSW;CKCCCTTSSNLQCYYYE;CSWANDPNCKCCCTTSSNLQCYYYE;CTCSENPNCHWCCCS;DPNCKCCC;EMEFYELITTPPN;HCTCSENPNC;HWCCCSWANDPNCKCCC;KDERNCQCCHCTCSENPNCH;KVYWTCPTEDVDSFEMEFYELITTP;NCHWCCCS;PMCSRLRLHSFML;RGRLTKRYMQQHGYLKWRFDRSS;RNCQCCHCTCSENPNCHWCC;YKDERNCQCCHCTCSENP 18 16 1.0012 -2.6944 0 6.18208 7.92955 8.45775 9.49239 7.99893 7.54813 0 9.66165 8.0072 0 3.28916 6.65807 7.54597 10.0048 A0A8P0NA24 A0A8P0NA24_CANLF Olfactory receptor family 5 subfamily B member 31 OR5B31 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVCKPLHYATT;DSRLHTPMYFFLS 2 7.6 0.99015 -0.26643 0 0 0 0 0 0 0 0 0 0 0 0 0 7.54218 0 A0A8P0NA35 A0A8P0NA35_CANLF Strawberry notch homolog 1 SBNO1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DASDHEESDY;EEDEPEEEDEEEMGHAETYAE;IRNNKKTAILVKEV;KVRKSDVKKF;LAREEIKNGKCVVIGLQSTGEA;LDELIDELG;RDESSEDDEDDP;TAPEYVFLISELAGEQRFASIV 8 9.3 1.0033 -2.0796 8.79669 10.5337 0 0 0 0 7.37756 6.79961 5.07711 0 0 0 8.96518 0 0 A0A8P0NA40 A0A8P0NA40_CANLF Centromere protein U (MLF1-interacting protein) CENPU Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] ELDVVLSAFEKTILEY;SAFEKTILEYEQNVESKTCKEAIKE;TCKNYPVRHRCC 3 9.9 0.99222 -0.19343 0 0 0 0 0 0 0 0 11.3148 8.94301 0 2.87878 0 11.5776 0 A0A8P0NA43 A0A8P0NA43_CANLF ADP ribosylation factor guanine nucleotide exchange factor 1 ARFGEF1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012] Golgi apparatus [GO:0005794] guanyl-nucleotide exchange factor activity [GO:0005085] DIVQSIVEEMVN;EAIRLIRH;GVQLQIIKA;LSDGPPDPKSHELRSKIL;PETINRYGSL;RILFRMYMDESRVSAWEEVQQRLLN 6 4.5 1.003 -0.78807 8.50946 0 0 0 0 0 0 0 0 7.62783 0 0 0 10.8147 0 A0A8P0NA54 A0A8P0NA54_CANLF General transcription factor IIH subunit LOC478089 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351]; nucleotide-excision repair [GO:0006289] transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] zinc ion binding [GO:0008270] HVILDESHYKELLTHH;SLTTCDPS;TIEDILFKAK;VSAPHLARSYHHLF;YVVVDGSRT 5 15.1 1.0019 -1.4644 0 0 6.93499 0 8.67398 0 13.6626 0 10.2218 0 8.12055 0 0 0 0 A0A8P0NA62 A0A8P0NA62_CANLF Olfactory receptor OR10Q2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VDEDRQFALVYTFVTPL;VLLQYGFCAVVYL;VYLRPQSTSSVDE 3 11.6 0.98644 -0.4562 0 0 0 0 0 0 9.70841 0 0 0 9.72702 0 10.8003 0 0 A0A8P0NA64 A0A8P0NA64_CANLF Charged multivesicular body protein 2B CHMP2B Canis lupus familiaris (Dog) (Canis familiaris) vacuolar transport [GO:0007034] late endosome membrane [GO:0031902] AAVRRRARLIRRRRLQV;ENMKMEMTEEMINDTLDDI;FDGSDDEEES;RARLIRRRRLQVTSPKSVL;SPELGKVLTQ 5 12.8 1.0001 -0.61416 0 7.66811 0 0 4.31803 5.99799 0 9.37608 0 4.52701 0 0 6.24755 0 0 A0A8P0NA72 A0A8P0NA72_CANLF Transcription factor 7 like 1 TCF7L1 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DNA binding [GO:0003677] AAPAATHS;EEKKPHVKKPLNAFMLYM;GGGGGGGG;GGGGGGSG;PVLQAQPLSLVTK;QLALHSAAFLSAKATATS;SNGPLSPGGART 7 15.5 1.0033 -1.5222 0 10.2873 9.99152 0 0 0 0 0 12.001 0 6.4949 0 11.3679 0 0 A0A8P0NA96 A0A8P0NA96_CANLF Interleukin 17 receptor D IL17RD Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] interleukin-17 receptor activity [GO:0030368] ELSLPLMEGLSADHTE;GIYDSSVPSSELSLPLMEGLSA;HTETSSLTESVSSSSGLGEED;LVDDTNTTRKVMHYALK;SREPVLEKFDSGLVL;VCKPGPDSSDFCLKA;WAGPIRAVAI 7 13.8 1.0029 -0.85221 9.29657 0 10.9524 0 0 0 0 11.7052 0 0 0 0 11.0376 10.82 0 A0A8P0NAC8 A0A8P0NAC8_CANLF ELKS/RAB6-interacting/CAST family member 2 ERC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; presynapse [GO:0098793] EEIESFRKENKDLKEKVNALQ;EEILEMKFKRKTIQ;IELTEENFRRLQ 3 5.4 0.9847 -0.25497 0 0 0 9.24869 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NAD8 A0A8P0NAD8_CANLF methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) MCCC2 Canis lupus familiaris (Dog) (Canis familiaris) L-leucine catabolic process [GO:0006552] ligase activity [GO:0016874] QENYEQMKALVDQL;YYPVTVKKHLRAQEI 2 8.9 0.91837 0.11498 0 4.81003 10.1635 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NAF8 A0A8P0NAF8_CANLF Tyrosine-protein kinase (EC 2.7.10.2) BLK Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] EDADAGLWQQRTRGE;NSIIPCTEEES 2 5.3 0.93823 0.089394 0 0 0 0 0 0 0 0 3.35361 9.62533 0 0 0 0 0 A0A8P0NAG4 A0A8P0NAG4_CANLF Dynein axonemal heavy chain 6 DNAH6 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AEAKMFLQ;ESLEDEGNIVIQMYKL;FLDGISGAINHFQNT;GQGQGPIAERMIKD;ISRVRQKLHIVL;IVVEEFLEDINNI;LSALEPVL;NLFEKDELEQ;NNEDKHYFHTILT;QYILLHPICIRIGSFETYINPYEWG;SDFPPAVKQTAPNIVE;SNDEIVQELVASVQ;SRDIPFFEM;TKSHNYWHPVLSSFQKL;VEKMKEKLP;VERLEEFRNEAKDVVR;VLSVPNLVPDTYFD;VLSVPNLVPDTYFDAFTR;VNVHLSVSNM;WEQEYLYHKELTKIPIFALFRKW;YKTGARAGTLSTTGHST 21 6.8 0.99951 -2.8882 0 9.89706 9.93565 11.5994 10.8872 0 10.3404 11.0968 11.6199 0 0 12.8566 10.5256 10.7222 11.0439 A0A8P0NAH9 A0A8P0NAH9_CANLF Copine 1 CPNE1 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent phospholipid binding [GO:0005544] KKDFLGKSD;LGGAECSL;VGVGGADF 3 4.7 0.99653 -0.57668 0 0 0 0 0 0 0 13.208 0 0 0 0 0 0 0 A0A8P0NAI6 A0A8P0NAI6_CANLF Olfactory receptor family 5 subfamily J member 2B OR5J2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LFLSCLSFVDACYS;YIQPSSQY 2 7.5 0.94194 0.061072 0 0 0 0 0 0 0 0 7.48929 0 0 0 0 0 0 A0A8P0NAI8 A0A8P0NAI8_CANLF RNA binding motif protein 12 RBM12 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DIVEDSIYIAYG;GLGLDVPGFGSGPNNL;NIQTFSTA;TLEDMREIEKNPP;TVPNFNNPSPSVVTA;VIPGSVCLKYNEKGMPTGEAMVAF;VSSAKVCAH;VVTAATSVHES 8 11.3 1.0023 -1.2009 0 0 0 0 0 0 0 0 0 8.27421 8.64176 0 7.45508 0 10.2386 A0A8P0NAL8 A0A8P0NAL8_CANLF GC-rich sequence DNA-binding factor 2 GCFC2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" nucleus [GO:0005634] DNA binding [GO:0003677] LITNCRVIHEELSTCANEVS 1 2.6 0.94907 0.050109 0 0 0 0 0 0 0 0 0 0 0 0 8.75869 0 0 A0A8P0NAM0 A0A8P0NAM0_CANLF Kelch repeat and BTB domain containing 4 KBTBD4 Canis lupus familiaris (Dog) (Canis familiaris) EAIEAWINFN;FVNYTFKDRSHSGRV;SVPGKDAI;VLSAQSCFF 4 8.1 1.0045 -2.0179 5.88277 0 0 0 8.8106 0 0 0 0 7.98692 0 12.1669 0 0 9.28836 A0A8P0NAQ1 A0A8P0NAQ1_CANLF DLG associated protein 4 DLGAP4 Canis lupus familiaris (Dog) (Canis familiaris) signaling [GO:0023052] ALDLPLPSYFRSRSHSYLRA;ISQIFGQASLIP;PLFAGPDRNPYLLSPTEAFARE 3 5.5 0.99462 -0.018834 0 0 0 0 0 0 0 0 12.6329 0 0 0 0 10.4175 7.33163 A0A8P0NAQ9 A0A8P0NAQ9_CANLF Ectodermal-neural cortex 1 ENC1 Canis lupus familiaris (Dog) (Canis familiaris) AACSRYFEAMFSGGLKES;LHEEWSKAAPML;NSIHPEVLE;SPSVSLKQVEHYDPTTNKWT;TAKRMSCHAVASGNK 5 12.6 1.0025 -0.89527 0 0 0 8.64418 0 0 0 9.5632 0 0 0 0 9.88827 11.6907 0 A0A8P0NAR3 A0A8P0NAR3_CANLF Homeobox protein cut-like CUX2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DSGEPDKGQGSP;EIREMVAPVLK;ESEGGERLHPDPL;FGHYVLGLSQGSVSE;GESKNSTAPLSI;GGGSSTAG;KFLLEKPG;MTNLEKANQRAEAAQ;PSPCLQPQDLSL;RREMLVEG;SIKDSLGTEQSYPSPP;TIELLSFQLNLKTNTVIN;VRQRGSITPRI;WHKLSLKGREPFVRMQLWLNDPHN 14 12.3 1.0035 -2.2127 0 8.11868 8.59395 13.0502 9.28061 8.26814 7.07778 12.7963 0 4.90448 0 0 8.36746 0 7.13658 A0A8P0NAU9 A0A8P0NAU9_CANLF Folliculin interacting protein 2 FNIP2 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal membrane [GO:0005765] EAVCIIADTDKW;FEYIHQDP;KGSGGGGG;NDPTEGSLEVEL;QVLNGSNITTALERGE;TDIRDLCTKPDKEGNTR 6 6.3 1.003 -2.1141 12.0878 0 0 0 0 0 11.2315 0 0 0 0 0 7.6414 0 0 A0A8P0NAW5 A0A8P0NAW5_CANLF Maestro heat like repeat family member 8 MROH8 Canis lupus familiaris (Dog) (Canis familiaris) FLKWKLPQ;LELTDSDIFDI;SIVRLKDWLHHGNRVFKFL;SNELFQFVMTTLDGLENLK;STKDHERERA;VAEEAAEG;VICARLSI 7 8.9 1.0028 -1.5352 0 9.45498 0 6.65406 3.8484 0 0 0 8.34979 0 10.9528 0 9.39489 0 0 A0A8P0NAX4 A0A8P0NAX4_CANLF GPN-loop GTPase 3 GPN3 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; hydrolase activity [GO:0016787] EESMNIVLQHIDFAIQYGEDLE;LVDSQFMVE;LVFCMEYFA 3 15.3 1.0033 -1.5605 0 0 9.45086 0 0 0 7.97985 0 0 0 0 0 9.92895 0 0 A0A8P0NAY1 A0A8P0NAY1_CANLF TRAF-type zinc finger domain-containing protein 1 TRAFD1 Canis lupus familiaris (Dog) (Canis familiaris) GVEDPDVIFQKFL;VIHPGRNLYPE 2 4.4 0.99283 -0.027657 12.476 9.64913 0 0 0 0 0 0 9.7399 0 0 0 0 0 0 A0A8P0NAY9 A0A8P0NAY9_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHA3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] DEHYTPIRTYQVCN;DTIAKISTECSH;ETFNLYYME;GFVCQACRPGFYKASDGNMKCAKCP;HYTPIRTYQVCN;LPRYGATLPTT;SPNVRFLP;VGPVNKKGFYLAFQDVGACVALV 8 10 1.0043 -1.0789 9.94879 0 0 6.88947 0 0 9.81658 6.95513 0 0 9.72359 11.4544 0 7.66747 4.43556 A0A8P0NAZ5 A0A8P0NAZ5_CANLF HECT domain E3 ubiquitin protein ligase 4 HECTD4 Canis lupus familiaris (Dog) (Canis familiaris) AADLCTDLAEEI;AEVGCSPC;DEDDDDVPQEDHYAL;DESDDEDDDDVP;DTTLTKTSPKNSLKGDKDPGEESE;ERMLEEKEEPGF;ESDDEDDDDVPQE;FEALPFAMASDSDNDAGTSIASD;HYKVELSYENFITSGPDPHPPPIAD;ILRKYGVPKPKFDKSKYSKGG;KPKFDKSKYSKGG;LLSKRKKVKMKRE;LTLLIILRHLTRKDPQG;MLYRDCARPPPP;NAADLCTDLAEEI;NQYPSVILSTDKVHIKLGVSPPP;RDITLEHLQ;TQGSPGLEDYFNDK;TVLSPTASEP;VGSTLSTVHLSSDG;YKFKETVHIPGARC 21 6.6 0.99898 -2.9344 9.55167 9.07428 14.7708 11.9635 9.19668 0 0 5.5995 0 12.0838 4.31266 0 6.99175 14.9363 10.3263 A0A8P0NB13 A0A8P0NB13_CANLF Phosphoinositide-3-kinase adaptor protein 1 PIK3AP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EKQKSGKQAD 1 1.2 0.98952 -0.19662 0 9.05791 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NB15 A0A8P0NB15_CANLF Zinc transporter ZIP13 (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) SLC39A13 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle membrane [GO:0030659] metal ion transmembrane transporter activity [GO:0046873] AALSGGHSLAQPAAEPGV;GVGLHMQCQP 2 6.9 0.99927 -0.61146 0 7.83939 0 7.46557 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NB25 A0A8P0NB25_CANLF Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) CIAPIN1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066] mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634] "2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]" SACGNCYLGDA 1 3.5 0.97917 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.46189 A0A8P0NB27 A0A8P0NB27_CANLF Coiled-coil domain containing 158 CCDC158 Canis lupus familiaris (Dog) (Canis familiaris) ALDKASLQFAECQDIIQ;CLWAEPLFLKRESQSQEDLRNQLQN;DKVIEILRQQIENMTQLVGQHG;FLKRESQSQEDLRNQ;LQELRSVINEEPAV;QEKRIQKVKDQEKM;QMERECLWAEP;QSQLEIIQEQARNQ;TEGSKSSDTLSREP 9 11.2 1.0022 -0.66448 10.0881 10.0836 0 0 10.94 5.22751 8.35103 0 8.79061 0 0 0 0 9.84403 10.248 A0A8P0NB35 A0A8P0NB35_CANLF Bactericidal permeability-increasing protein (BPI) LOC102156842 Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087] extracellular space [GO:0005615] lipid binding [GO:0008289] KGLEYARQ;VELMEVILNYYAL 2 4.4 0.98493 -0.43767 0 0 0 0 0 0 0 9.76085 0 0 0 0 0 0 0 A0A8P0NB67 A0A8P0NB67_CANLF Protein Mis18-alpha MIS18A Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" AGVGSSGCLEGCSSTSCACGG;EPAEEEEEEEEEE;GDKDKWGRRLSEDSSRHQLLQKW;IVSEDKELFNLESR 4 29.4 0.98642 -0.39305 8.77251 0 0 0 9.85734 0 0 0 0 8.46769 0 0 8.66238 0 0 A0A8P0NB77 A0A8P0NB77_CANLF Cyclic nucleotide binding domain containing 1 CNBD1 Canis lupus familiaris (Dog) (Canis familiaris) HYRTSIPR;KFPPGHMIVE;KLEPKKAKKIKKLV;KLEPKKAKKIKKLVCMGKLKEKES;VISETWVKGSTVVGND 5 11.4 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 8.05121 0 0 0 0 0 A0A8P0NB79 A0A8P0NB79_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCH1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; calcium-dependent phospholipase C activity [GO:0050429]; phosphatidylinositol phospholipase C activity [GO:0004435] DVSLLCAAHPDSHSAAVLQ;EDSLAKRQRTHDQWVKQTFEEADKN;EGCRCVEVDCWDGPDGEPV;EPALTAAQGGVS;HGSVLHTE;HRAAPPPAG;KPGPAAGV;SAHTLHQTTCATAPRPPPED;SLVPGYRHVYLEG;VGQCEDAGEPGSL 10 8.8 1.0042 -1.0523 10.4234 0 10.5907 0 0 7.98459 0 0 0 10.8782 11.1329 10.0231 0 8.48671 9.79812 A0A8P0NBA9 A0A8P0NBA9_CANLF Forkhead box F2 FOXF2 Canis lupus familiaris (Dog) (Canis familiaris) system development [GO:0048731] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] AARVLRLLRARRRRRRRRQ;CPVPAGPG;GGGGGGGD;GGGGGGGG;LKQPPALPP;PAARVLRLLRARRRRRRRR;PGGGGGGG;RARRRRRRRRQRGRRLLQ;RLLRARRRRRRRRQRGRRLLQGR;RVLRLLRARRRRRRRRQRGRR;RVLRLLRARRRRRRRRQRGRRLLQ;VLRLLRARRRRRRRRQRG 12 9.2 0.99113 -0.14667 5.89644 0 7.87486 9.45354 4.52726 0 10.6774 10.6074 10.605 10.2152 6.45973 10.4228 11.5601 3.25228 0 A0A8P0NBB2 A0A8P0NBB2_CANLF Cell division cycle associated 2 CDCA2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GELEEELEEAKPPKGKSLLPQSPED;LQEHCDNLCDDGTH;RKLTRRVLPKKN;SLQEHCDNLCDDGTHP;VSGKENREGFAAGSSS 5 6.6 0.73276 0.24534 10.5535 0 0 0 0 0 0 8.85234 10.6325 8.19397 0 0 0 0 10.4625 A0A8P0NBG2 A0A8P0NBG2_CANLF protein-lysine 6-oxidase (EC 1.4.3.13) LOXL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] "copper ion binding [GO:0005507]; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [GO:0016641]" AATYRQQPSFPQPF;AERPYAPPPPAP;GAPSCCSCC 3 4.6 1.0019 -1.3039 0 0 0 0 0 0 9.5283 0 4.16277 0 0 12.6134 0 0 0 A0A8P0NBG5 A0A8P0NBG5_CANLF Gametocyte specific factor 1 like GTSF1L Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CVNRSTMEEEDSLHPL;YNACHVVPIKNLEE 2 19.1 0.99428 -0.13157 0 0 0 9.7029 0 9.93252 0 0 6.98971 0 0 0 0 0 0 A0A8P0NBG8 A0A8P0NBG8_CANLF Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A) ESRP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] nucleus [GO:0005634] RNA binding [GO:0003723] GSPTSLGYFP;GVGTSFCLCTDG;TAGATGAK 3 4.6 1.0029 -1.6654 9.09458 0 0 0 0 0 0 0 9.93023 5.29594 0 0 0 0 0 A0A8P0NBH7 A0A8P0NBH7_CANLF Tubulin beta chain LOC478702 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] LVDLEPGTMDSV;VISDEHGIDPTGS 2 5.8 0.93618 0.066751 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.84161 A0A8P0NBJ7 A0A8P0NBJ7_CANLF "PMS1 homolog 1, mismatch repair system component" PMS1 Canis lupus familiaris (Dog) (Canis familiaris) mismatch repair [GO:0006298] mismatch repair complex [GO:0032300]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] HKLPAQPLEKPIILTESL;KPTSAWNLAQKHKLK;KSGKNTNY;LVSENYGFDKIEVRDNGEGI;TASDNFSTQYVLDG 5 8.4 0.94842 0.050028 0 9.92721 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NBJ9 A0A8P0NBJ9_CANLF Enoyl-CoA delta isomerase 2 ECI2 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome [GO:0005777] delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062] ASQKDFESAMNQVKLLKK 1 4.9 0.97054 0.048313 0 0 0 0 0 0 0 0 10.5505 0 0 0 0 0 0 A0A8P0NBK5 A0A8P0NBK5_CANLF 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) HMGCR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299] endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778] hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADP binding [GO:0050661] AAQNVGSSNCITL;AIYIACGQDAAQNVG;GVAGPLCL;IGYMPIPVGVAGPLCLD 4 4.4 1.0025 -1.7725 7.8205 8.04652 0 0 0 0 8.62596 0 0 9.42945 0 0 0 0 0 A0A8P0NBK9 A0A8P0NBK9_CANLF F-box and WD repeat domain containing 8 FBXW8 RNFT2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of ERAD pathway [GO:1904294] membrane [GO:0016020] ubiquitin protein ligase activity [GO:0061630] IVALPKIILAVKSKGKFYLVIE;VGGVRKALKLL 2 8 0.94568 0.08219 0 2.40117 0 0 5.43806 7.2636 0 0 0 0 0 0 0 0 0 A0A8P0NBN7 A0A8P0NBN7_CANLF Family with sequence similarity 243 member A C21orf140 Canis lupus familiaris (Dog) (Canis familiaris) LCIKREESLFFE;VISLMSIVCCPEVAK 2 10.7 0.9937 -0.020955 0 0 0 9.34541 0 0 0 0 0 0 0 0 0 0 12.102 A0A8P0NBP6 A0A8P0NBP6_CANLF Protein phosphatase 1 regulatory subunit 15B PPP1R15B Canis lupus familiaris (Dog) (Canis familiaris) regulation of phosphate metabolic process [GO:0019220]; regulation of protein modification process [GO:0031399] DLETSSDSGGETWDEEAED;EDAGPPERPKAELTCAS 2 5.2 0.99409 -0.15569 0 0 5.17951 0 0 0 0 0 0 0 0 0 0 10.6315 0 A0A8P0NBQ2 A0A8P0NBQ2_CANLF Interphotoreceptor matrix proteoglycan 2 IMPG2 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cell projection [GO:0042995]; extracellular region [GO:0005576]; interphotoreceptor matrix [GO:0033165]; membrane [GO:0016020] heparin binding [GO:0008201] ELPCQSLCDLQPGFCLNDG;TDEPNLPFLKEDMEQTT;VTFNGEAIGNTTWDLISL 3 4.4 0.86775 0.14395 0 5.28477 0 0 0 0 0 0 9.23903 0 8.25791 0 0 0 0 A0A8P0NBR3 A0A8P0NBR3_CANLF ethanolamine kinase (EC 2.7.1.82) ETNK2 Canis lupus familiaris (Dog) (Canis familiaris) AAGAGCRE;HNYFTLVKN;LVACYVEEDMQDCV;QVRTKRFTDGI;YPGRDTQL 5 13 1.0022 -1.2239 0 9.26512 0 9.94856 0 0 0 7.91498 11.5432 0 0 0 0 7.96261 5.87625 A0A8P0NBS5 A0A8P0NBS5_CANLF FHF complex subunit HOOK interacting protein 2B FHIP2B Canis lupus familiaris (Dog) (Canis familiaris) DIAALEGISWRLPSA;EPERPFFEGHFLRMLFD;PAAPDDGP 3 5.4 0.98646 -0.3871 0 0 0 0 9.3684 10.9012 0 0 0 8.21383 0 6.77558 7.31678 0 8.89017 A0A8P0NBU3 A0A8P0NBU3_CANLF Transmembrane protein 117 TMEM117 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLIFAEDPVSHSQTE;GGGGGGGA;GGGGGGGG;VGWRILKVLLWLLAI;VGWRILKVLLWLLAILIGLI 5 8.7 0.97914 0.046252 0 10.6019 10.7383 0 0 3.79067 0 0 0 0 0 4.05172 0 0 0 A0A8P0NBW6 A0A8P0NBW6_CANLF Synaptonemal complex protein 2 like SYCP2L Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] GPYRLMKDLAGTILTVGD;LQQRASHIPQ;LRYFFQNFQ 3 5.2 1.0025 -1.3674 0 0 0 0 0 0 9.61156 0 0 0 0 0 0 7.39866 0 A0A8P0NBX3 A0A8P0NBX3_CANLF Patatin like phospholipase domain containing 2 PNPLA2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; positive regulation of triglyceride catabolic process [GO:0010898] triglyceride lipase activity [GO:0004806] ARAGPAPAPAKSP;DPGALPSP;LGDALAKWEE;YHIGVASCLRE 4 6.6 0.99032 -0.26592 0 0 0 0 0 0 0 0 0 0 12.0419 0 0 0 0 A0A8P0NBY5 A0A8P0NBY5_CANLF Terminal nucleotidyltransferase 5C (EC 2.7.7.19) TENT5C Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] poly(A) RNA polymerase activity [GO:1990817] LVKVCTDTDRWSL;RLIATKNPEEIRGG;YQPAPYVSD 3 9.2 0.99095 -0.21101 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5448 A0A8P0NBZ2 A0A8P0NBZ2_CANLF Mucin-19 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] GSEYDQGSVTLVGCN;GTFRILTESIPCC;GVYVFKPS;HCDKIIGTYFEK 4 4.1 1.0017 -1.3118 0 0 0 8.49005 0 0 7.74059 0 0 0 6.29066 0 0 0 0 A0A8P0NC05 A0A8P0NC05_CANLF TBC1 domain family member 7 TBC1D7 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765] GTPase activator activity [GO:0005096] EEKKSLEILLKDDRLDI;PQLPKAFEQYL 2 9.7 0.99412 -0.18875 0 0 0 0 10.5695 7.31316 0 0 0 0 0 0 0 0 0 A0A8P0NC44 A0A8P0NC44_CANLF Tetraspanin TSPAN32 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MAGGFLCFALVFGALVE 1 5.8 0.99377 -0.12971 0 0 0 0 0 0 9.57983 0 0 0 0 0 0 0 0 A0A8P0NC59 A0A8P0NC59_CANLF Beta-galactosidase (EC 3.2.1.23) LOC606786 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] beta-galactosidase activity [GO:0004565] GASAQPRPAPSFNWSHLT;TSYDYDAV 2 4 0.97928 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 8.64137 0 0 A0A8P0NC70 A0A8P0NC70_CANLF Cadherin 22 CDH22 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] ALLVCVLILVVLVLLILTLRR;CVLILVVLVLLILTLRRHH;DRATNRLLEPESEFI;ILVVLVLLILTLRRHHKSHLS;LDQIFDIDADTGAIV;LILVVLVLLILTLR;LILVVLVLLILTLRRH;LILVVLVLLILTLRRHH;LLLLLLLP;LLVCVLILVVLVLLILTL;LVPEAPSNPHFSLLDIQ;TQEAIIVVQKRLDFESQPVHTV;VLILVVLVLLIL;VLILVVLVLLILT;VLILVVLVLLILTLR;VLVLLILTLRRH;YDMSALRSLY 17 13.9 0.99232 -0.006567 6.91636 9.87147 0 7.64983 8.12034 6.65607 5.76678 11.1653 10.3707 6.2157 0 3.79421 0 7.62549 10.028 A0A8P0NC71 A0A8P0NC71_CANLF "gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" BBOX1 Canis lupus familiaris (Dog) (Canis familiaris) carnitine biosynthetic process [GO:0045329] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506] EHCSEFEADWL;FEDVLKNDEHAY;LQRELFLPECQYWGAELQLP;SQQAREKLQRELFLPECQYWGAE;VLKLGKRIGFLY 5 16 0.98733 -0.36349 10.5117 0 9.43532 0 0 8.85087 0 0 0 0 0 0 5.5537 0 9.12686 A0A8P0NC80 A0A8P0NC80_CANLF Vasopressin V1b receptor AVPR1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] vasopressin receptor activity [GO:0005000] CYSLIYHEICKN;NLSSCCNP;VTYRFQGPDLLC 3 7.6 1.0032 -1.5047 0 0 0 0 0 6.82858 0 0 0 8.27188 0 0 0 10.7022 0 A0A8P0NCA3 A0A8P0NCA3_CANLF Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) KCNA4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] axon [GO:0030424]; voltage-gated potassium channel complex [GO:0008076] potassium ion binding [GO:0030955]; voltage-gated potassium channel activity [GO:0005249] ELSDEDEDDEDDEDAEEEA;IFFLFIGVILFS;IIRLVRVFRIFKLSR;ILRIIRLVRVFRIF;RRRRRSRPNRRRPQP;SDEDEDDEDDEDAEEEAR 6 9.8 0.99209 -0.17994 7.19859 0 0 0 0 0 0 0 9.025 0 0 0 4.87293 0 0 A0A8P0NCB8 A0A8P0NCB8_CANLF tRNA-t(6)A37 methylthiotransferase (EC 2.8.4.5) CDKAL1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; N6-threonylcarbomyladenosine methylthiotransferase activity [GO:0035598]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase [GO:0061712]" DIEDIVSQ;DIVSQGDLKPQ;LLDDIEDI;VGLALFALLLAFLVK 4 6.1 1.0034 -2.4417 0 0 0 10.0315 0 0 0 0 0 0 0 0 9.63389 0 0 A0A8P0NCD0 A0A8P0NCD0_CANLF Rap1 GTPase-GDP dissociation stimulator 1 RAP1GDS1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739] guanyl-nucleotide exchange factor activity [GO:0005085] DSDKEDDIAELKTASD;TLGARPAPRRLLGERAPSGLGLAEA 2 4.4 0.98705 -0.23498 0 0 0 0 0 0 0 0 0 0 0 10.1992 0 0 0 A0A8P0NCD3 A0A8P0NCD3_CANLF Doublecortin domain containing 2 DCDC2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] EGGDLEATEASEEVEEVP;TDEENGEELDQV;VIHEKKVSSFDVFLKE 3 10 0.99278 -0.16929 0 0 0 0 0 0 0 0 0 7.69905 0 0 9.93671 0 9.48919 A0A8P0NCD8 A0A8P0NCD8_CANLF U3 small nucleolar ribonucleoprotein protein MPP10 MPHOSPH10 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] Mpp10 complex [GO:0034457]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732] DEDISLLPEIEEREC;EEEEIADEEESISE;KDFFDPVESDEDLASVH;KEEQQKDDEEEEDIDFFEDINS 4 10.1 0.98696 -0.39844 0 0 0 0 0 0 0 0 0 0 0 0 4.68818 9.80916 0 A0A8P0NCE8 A0A8P0NCE8_CANLF Transient receptor potential cation channel subfamily M member 1 TRPM1 Canis lupus familiaris (Dog) (Canis familiaris) protein tetramerization [GO:0051262] membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] AKGKKKKKKK;EENMDANADAGSR;EQAMLDALVLDRV;GVNMQHFLTI;IVLEYLREDPPV;KKKKKKKK;PVVGLVVE;RSTDIPYIVSEAVMQAE;SISNQVWKFQRYQLIMTFHD;VSEMVPQISHLS 10 7.4 1.0024 -1.7484 0 0 6.40555 0 12.8163 0 9.0224 6.97831 13.7848 0 0 0 9.82606 6.82972 0 A0A8P0NCF7 A0A8P0NCF7_CANLF Tubulin alpha chain TUBA5 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] DLVLERIRKL;EFAIYPAP;GVRTGTYRQLFHPE;THTTLEHSDC;TVVPGGDLAKVQ 5 13.8 1.0029 -0.86558 0 0 0 0 10.5015 0 0 0 3.20845 0 0 0 0 7.9257 0 A0A8P0NCH8 A0A8P0NCH8_CANLF "Glutaredoxin-2, mitochondrial" GLRX2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" AAGAAASG;AALRATRP;LFHDMNVKY 3 16.1 1.0033 -2.455 7.89664 0 0 0 0 0 0 0 0 0 0 0 11.7039 9.90627 12.2298 A0A8P0NCH9 A0A8P0NCH9_CANLF FAM124 domain-containing protein FAM124B Canis lupus familiaris (Dog) (Canis familiaris) GSLQCPESGESP;LVPLLPHPCVP;VQGEEKEEEEFF 3 7.6 0.98686 -0.35798 0 0 0 11.24 0 8.67331 0 0 0 12.7063 0 12.9415 0 12.1072 11.9585 A0A8P0NCI2 A0A8P0NCI2_CANLF Plakophilin 2 PKP2 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] EAELPDRYS;HNAYKKGSI;MRRCDGLIDSLVHYVRGTIADYQ;PKLLQLLKVQN;SLVGNGNL;YDMLKTGTT 6 8.4 0.99918 -3.2143 9.30522 0 0 0 6.92873 9.23304 9.69808 0 0 0 0 0 0 8.52931 0 A0A8P0NCJ4 A0A8P0NCJ4_CANLF E74 like ETS transcription factor 3 ELF3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] KLSRAMRYYYKRGILE;YYKRGILERVDGRRLV 2 6.5 0.9357 0.098466 0 0 0 7.71287 8.11572 0 0 0 0 0 0 0 0 0 0 A0A8P0NCL7 A0A8P0NCL7_CANLF Small-subunit processome Utp12 domain-containing protein PWP2 Canis lupus familiaris (Dog) (Canis familiaris) ribosome biogenesis [GO:0042254] nucleolus [GO:0005730] ELPEFNLIH;GQGDGAAQ;ISKLCDWNRYN;SLDLYTLSQDGALCVW 4 4.8 0.98996 -0.26592 14.2552 0 0 0 0 0 0 13.5205 13.5093 0 0 0 0 0 0 A0A8P0NCM0 A0A8P0NCM0_CANLF Histone-binding protein RBBP7 (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) RBBP7 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634] KIGEEQSAEDAEDGP;PEGKDYALH 2 6.2 0.99397 -0.13254 0 0 0 0 0 0 0 0 0 0 12.578 0 13.5285 0 0 A0A8P0NCS3 A0A8P0NCS3_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of neuroinflammatory response [GO:0150077] cell surface [GO:0009986]; membrane [GO:0016020] signaling receptor activity [GO:0038023] AITHEGYYTC;PKTDILSSEYFLA 2 8 0.99652 -0.57391 0 0 0 8.87092 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NCS9 A0A8P0NCS9_CANLF T cell immunoreceptor with Ig and ITIM domains TIGIT Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of T cell activation [GO:0050868] membrane [GO:0016020] signaling receptor binding [GO:0005102] ESVSYMPL;VLQSSVAERSAAFQIP 2 7.6 1.0024 -0.73848 0 0 0 0 0 0 9.4301 0 0 0 0 0 0 0 0 A0A8P0NCT1 A0A8P0NCT1_CANLF dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) TMTC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] GTLTRDAAEAKMY;PLFSEQDNPASFSPYI;RQAGPRGPASASRAPRA;VPDSKLLQENLAKLDRLEKRL 4 5.8 0.98729 -0.40609 0 0 0 0 0 0 0 0 9.4719 7.84681 0 0 0 5.54278 0 A0A8P0NCU2 A0A8P0NCU2_CANLF Testis expressed 55 TEX55 Canis lupus familiaris (Dog) (Canis familiaris) AEGRASGQTDSRRSSQTE;EPPAESLGP;EQRTDGQMEHRR;EQTDPRTAEQTAQGMSGQT;GGAQETNSQMFL 5 18.2 0.98859 -0.34305 0 0 0 9.73715 0 9.27466 0 0 0 0 5.038 0 0 10.9355 0 A0A8P0NCV5 A0A8P0NCV5_CANLF Chromosome 27 C12orf71 homolog C27H12orf71 Canis lupus familiaris (Dog) (Canis familiaris) ESTGRLLKRQDQIPDNPKQCC;QEEDFQLFSS;SLDLGQTLSPDF 3 13.5 0.98789 -0.48852 0 0 0 0 9.55401 0 5.74163 0 0 0 0 0 0 0 0 A0A8P0NCY2 A0A8P0NCY2_CANLF Testis expressed metallothionein like protein TESMIN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AGYCDCFASGDFCNNCN;AGYCDCFASGDFCNNCNCNNCC;CDCFASGDFCNNCNCNNCC;CDCFASGDFCNNCNCNNCCN;CDCFASGDFCNNCNCNNCCNN;CECYEESEGEEG;CNNCNCNNCCNNL;DCFASGDFCNNCNCNNCC;DFCNNCNCNNCC;ESQVKVELVVEDNDEE;GYCDCFASGDFCNNCNCNNCC;NCNCNNCCNNLHHEIQ;SGDFCNNCNC;YCDCFASGDFCNNCNC 14 10.9 1.0021 -1.3014 7.48027 8.57788 0 0 9.98185 3.76532 6.13611 0 7.85518 8.16078 8.27421 4.95531 4.77458 9.5534 8.56929 A0A8P0NCY3 A0A8P0NCY3_CANLF Chromosome 37 C2orf69 homolog C37H2orf69 Canis lupus familiaris (Dog) (Canis familiaris) CEEFDESTLSFYPP;GGGGGGGG;LNGASFTLIGFSK 3 10.7 0.98584 -0.42918 0 0 9.86726 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NCY5 A0A8P0NCY5_CANLF RNA helicase (EC 3.6.4.13) DDX59 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] VPRSLKIKRNA 1 1.9 0.99003 -0.26217 0 0 0 0 0 0 10.3321 0 0 0 0 0 0 0 0 A0A8P0NCZ5 A0A8P0NCZ5_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" SLC25A6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743] ATP:ADP antiporter activity [GO:0005471] DFWVLPQHPLHPG;VLSFWRGNLANV 2 5.2 0.94473 0.059632 0 0 9.21531 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NCZ6 A0A8P0NCZ6_CANLF Hyaluronan binding protein 2 HABP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DWTPDYYEDSYEYHNQEEDVNR;IKATIQKGSSF;KLKPVDGH;NGENFTCS;YSLYNEREEIPHNDIAL 5 11.8 1.0022 -1.3014 0 8.82429 0 0 0 4.00027 0 0 10.7154 10.9417 0 0 0 0 0 A0A8P0ND02 A0A8P0ND02_CANLF Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36) EIF3I EIF3S2 Canis lupus familiaris (Dog) (Canis familiaris) formation of cytoplasmic translation initiation complex [GO:0001732] eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] translation initiation factor activity [GO:0003743] NSAALSPNYDHVVL;PVNSAALSPNYDHVVL;RDMTMFVTASKDNTAKLF;RFPRVNARMKPILL;YARERGHSETHLSIQEEGLH 5 12.3 0.98835 0.03178 0 0 9.22704 0 0 0 10.1106 0 0 0 0 0 7.15613 0 10.9186 A0A8P0ND12 A0A8P0ND12_CANLF Fibulin-5 FBLN5 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CMCPAENPGCRDQ;CRGDMMCVNQNGGYLC;EEPYLRISDNRCMCPAENPGCRDQP;GVHCSDMDECSFS;LEDDGVHCSDMDECSFS;QMQATTRYPGAYY 6 16.1 1.0011 -0.70699 0 11.7985 9.90603 0 0 0 0 0 8.77099 0 0 0 5.54269 0 0 A0A8P0ND15 A0A8P0ND15_CANLF ADP-ribosylarginine hydrolase ADPRH Canis lupus familiaris (Dog) (Canis familiaris) ADP-ribosylarginine hydrolase activity [GO:0003875]; magnesium ion binding [GO:0000287] MDGRAPGCASVQN;SYFQDQWEKYLKLRGI;VKERDQFYT 3 10.5 0.9872 -0.38314 0 0 0 0 0 0 0 0 0 0 11.149 9.51525 0 0 0 A0A8P0ND16 A0A8P0ND16_CANLF Usherin USH2A Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; membrane [GO:0016020] CTGAGCAC;DKGLSRFTTYEYQ;EDCEHNTTGRNCELCK;ESAEEICSYAE;FTVEQQENGR;GCTSSEPFLGQTLQAAPEGVWVTP;GSRKAHVRWE;GVSPPRWTKMDNL;HQTKISFFINGLE;ISSDSVTLAWNSPSN;LAHNEVGSTASEWISF;LEACTGAG;NDDGCEPCQCN;PGAPDGVL;PGEVCCPDEQHNRVSTGIGDSCC;PPKKPNGV;PTSLQDGAQFLGTGFLE;QEILVNWDAPVRT;QGCQMCECDSL;QIRIHFHGQYYTTET;SPSNPNGV;SSATPTSLQ;SSGGCSTS;STPQEAPQEVQ;TASLEGLQPYTT;TEDQYPYSIQ;TTPGEKRGSGS;VCTKYACV;VEACTCFNCCS;VITSYGLYLDGILI;VNGSLLCDKSTGQ;YSIEVTWDEPVVV 32 7.4 0.99673 -8.5078 11.1013 9.19286 8.13361 6.93463 10.864 7.67849 10.7281 13.1273 9.4821 7.91695 10.2529 8.63452 11.5403 20.2444 11.5841 A0A8P0ND52 A0A8P0ND52_CANLF Alkaline phosphatase (EC 3.1.3.1) ALPI Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; side of membrane [GO:0098552] metal ion binding [GO:0046872]; phosphatase activity [GO:0016791] IDKAGQLTSERDTLTLVTAD;LLLLLLLGLRPRLALGII;LLLLLLLGLRPRLALGIIP;RVLLLLLLLGLRPRLALGII;TDAALPGP;VILGGGRK;VLLLLLLLGLRPRLALG;VLLLLLLLGLRPRLALGIIP;VLLLLLLLGLRPRLALGIIPA 9 8.7 1.0024 -1.8679 8.95268 4.88938 5.29197 0 0 5.97641 7.17093 0 0 0 0 0 0 9.34558 4.67288 A0A8P0ND53 A0A8P0ND53_CANLF Pannexin PANX Canis lupus familiaris (Dog) (Canis familiaris) monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; positive regulation of interleukin-1 production [GO:0032732] gap junction [GO:0005921]; plasma membrane [GO:0005886] channel activity [GO:0015267] PSNFSARQAAYVDSSC 1 4.1 0.95057 0.05297 0 0 0 0 0 8.03298 0 0 0 0 0 0 0 0 0 A0A8P0ND62 A0A8P0ND62_CANLF RNA helicase (EC 3.6.4.13) DDX27 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] DILIATPG;GSELEEQED;IVADHSPHSP;LKEIVKAAKAPVKARILP;PTKLVLPRGLHICSFL;QEDHEGKDEEGPED 6 9.5 1.003 -2.1946 9.48913 0 0 0 0 7.06113 10.3529 0 0 0 0 0 0 0 0 A0A8P0ND66 A0A8P0ND66_CANLF tRNA-yW synthesizing protein 5 TYW5 Canis lupus familiaris (Dog) (Canis familiaris) AAVAQMDF;RMRSTTYGHLEKTLE 2 14.6 0.86037 0.14681 0 0 0 0 0 0 0 11.3458 0 0 0 0 0 0 0 A0A8P0ND82 A0A8P0ND82_CANLF "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1)" SDHA Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900]; tricarboxylic acid cycle [GO:0006099] mitochondrial inner membrane [GO:0005743] "flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]" AGVGGTARWRTDMSGVRA;ASRDVVSRSMTLE;ELRLNMQKSMQSHA;LDLLMENGECRGVIA;VVVGAGGA 5 9.4 0.98736 -0.35483 5.33835 17.6275 0 0 0 9.79482 0 0 0 17.634 0 0 9.57405 5.48617 0 A0A8P0ND83 A0A8P0ND83_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF123 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] AAGASTTS;AQVEQMLAH;ELIPTTWWPHRSSREGKDSKD;LGGLLSHL;NSVLNQLNWAF;TDYISLEELAQVEQ;TLTRLAAILAKHFAD;YFGPVHSMEELPGYEET 8 7.4 0.99741 -3.4289 0 9.44315 0 0 0 0 0 4.19275 0 0 9.82745 0 9.65039 12.6004 0 A0A8P0NDA2 A0A8P0NDA2_CANLF Leucine rich repeat containing 58 LRRC58 Canis lupus familiaris (Dog) (Canis familiaris) LSYLVLCDNKIQ;PELANLPS 2 3.5 1.0026 -0.71886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4551 A0A8P0NDA9 A0A8P0NDA9_CANLF Dehydrogenase/reductase X-linked DHRSX Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" LVMSLMYET 1 2.9 0.98327 -0.25622 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.60455 A0A8P0NDB3 A0A8P0NDB3_CANLF Complement factor I CFI Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] DENGCQETEY;DENQKQWIRKTQLS;EDENGCQETE;GVCIPNKYKCNGE;ISHHVGRSLISQYNV;IWTSFLSSLRP;QETEYLTANMDAERKRIKS;RSLISQYNV;VGRSLISQYNV;VVGGKAAVMG;VVGGKAAVMGD;VVGGKAAVMGDF;YQIWTSFLSSLRPDNDTVVQ 13 16.8 0.52047 0.4631 11.4127 9.25016 11.7084 11.6883 11.6748 12.1995 9.91447 12.5215 10.1738 12.3527 12.3367 10.8488 12.0727 10.9796 8.49029 A0A8P0NDF6 A0A8P0NDF6_CANLF "Leucine rich repeat, Ig-like and transmembrane domains 3" LRIT3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EPGRQYIACVCPK;VKLRIEKTVIRRIPA 2 4.1 0.91929 0.11358 0 0 0 0 0 0 0 0 0 0 0 3.97939 0 9.44644 0 A0A8P0NDI0 A0A8P0NDI0_CANLF Coiled-coil domain-containing protein 39 CCDC39 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159] axoneme [GO:0005930] EAWLEESAH;EIEGTRSSLKHLNHQ;LEVIEHLTNNVKEKLSEK 3 4.8 0.99249 -0.19284 0 0 0 0 0 10.001 0 0 0 0 0 0 0 10.1869 0 A0A8P0NDM1 A0A8P0NDM1_CANLF Neuroguidin NGDN Canis lupus familiaris (Dog) (Canis familiaris) filopodium [GO:0030175] DQNPIKKRKKILKKGRKKKGFRRRR;IKKRKKILKKGRKKKGFR;KKRKKILKKGRKKKG;KRKKILKKGRKKKGF;NPIKKRKKILK;NPIKKRKKILKKGRKKK;PIKKRKKILKKGR;PIKKRKKILKKGRKKKGF;RKKILKKGRKKKGFR 9 7.9 0.93878 0.10303 0 6.31058 0 5.76243 0 9.36529 10.2425 7.23745 0 0 0 5.57307 4.74502 7.10339 0 A0A8P0NDN3 A0A8P0NDN3_CANLF Zinc finger protein 202 ZNF202 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EDDFTCRPE;PEILSFTYTGDRSED;QEVLSEETIHPGADP 3 6 1.0009 -0.62158 10.7845 0 7.28457 8.35711 0 10.4611 0 0 9.02885 0 0 0 0 0 0 A0A8P0NDN5 A0A8P0NDN5_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRU Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] ILLLGAIIIIIRK;LAVLILLLGAIIIIIRKG;LILLLGAIIIIIRKGRDHYAYSY;LLLGAIIIIIRKG;MLDMAECEGV;VGRVKCSRYW;VKMEQGVSRYTIKNLLPYR;VSTFWPNEYQVLFEAL;WEQVHIHPGTR 9 6.4 0.9786 0.046253 0 5.38267 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NDN8 A0A8P0NDN8_CANLF Fc alpha and mu receptor FCAMR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HICHTIVS;TVPIPESP 2 3.3 0.98775 -0.48087 0 0 0 0 0 0 0 0 0 0 0 10.5508 0 0 0 A0A8P0NDP1 A0A8P0NDP1_CANLF Alpha kinase 1 ALPK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ATGTWLYRNESDKVLVQS;CISVEPYI;DQLLLEASDVSQE;DSGKSSGS;DVERQMTAQHYVT;DYEKFKNNPQI;EETFELIESPEINCDARD;ERQMTAQHYVTEFNKRLYEQN;KDDSLESSQNQLQKHV;KDTKTEVCITTL;VETEIEPPDYSH;VGPEDKTNLQ;VLNKSLSDSH 13 12.9 0.99879 -2.9859 0 10.7344 10.6379 10.2692 10.1668 0 0 10.8571 11.6285 0 10.9636 0 0 8.8577 0 A0A8P0NDP3 A0A8P0NDP3_CANLF Cell adhesion molecule 3 CADM3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GEAISSTVWSS;IVCSVNHESLKGADRSTS;SWRSSSSCCSSC 3 9.8 0.95544 0.05044 0 0 6.63161 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NDQ5 A0A8P0NDQ5_CANLF Exocyst complex component 8 EXOC8 Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887]; protein transport [GO:0015031] exocyst [GO:0000145]; growth cone [GO:0030426]; perinuclear region of cytoplasm [GO:0048471] EEAAAPRGPPQ;GGPKATRRAVS;LDKLNHYLEDKP;VHTAIRQL 4 6.2 1.0027 -1.0098 0 0 9.06229 0 0 0 0 0 0 0 0 0 0 8.68986 0 A0A8P0NDR2 A0A8P0NDR2_CANLF Aspartate beta-hydroxylase domain-containing protein 2 ASPHD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] dioxygenase activity [GO:0051213] FYLVNQGVCVPR;PEVFFLPD;VITEHYGPTNIR 3 8.7 1.0023 -0.7673 0 0 8.15132 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NDR3 A0A8P0NDR3_CANLF Testis expressed 2 TEX2 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] endoplasmic reticulum membrane [GO:0005789] lipid binding [GO:0008289] DEPSREAEPKASQGSGL;EEECDSEGDGSGSDPSVPGSDHP;ESNNNYSIKEEECDSEGDG;KEPEILKGW 4 5.5 1.0031 -1.1216 0 0 0 0 8.35909 0 0 12.4438 0 0 0 0 5.07198 10.1828 0 A0A8P0NDR7 A0A8P0NDR7_CANLF Ankyrin repeat domain 13D ANKRD13D Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ARPARPPRRLRRRRRRRRR;ARPARPPRRLRRRRRRRRRRRRRR;ARPARPPRRLRRRRRRRRRRRRRRH;THLDTRNVAFERNK 4 5.9 0.86912 0.18739 6.22601 0 10.0221 0 0 0 0 0 6.21134 0 0 0 0 0 5.8117 A0A8P0NDX1 A0A8P0NDX1_CANLF Immunoglobulin superfamily member 9 IGSF9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAWGPGGP;PVTRVLLKAPPAFLER;QVLEVQELEP;SYLSPAPGDTSS;VPVGAAYL 5 3.7 1.0047 -1.1044 0 0 0 0 0 0 0 0 0 9.94015 0 0 0 0 0 A0A8P0NDX5 A0A8P0NDX5_CANLF XK-related protein XKR8 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] plasma membrane [GO:0005886] LGLALRLVYYRWLHPRCRQEP;RALRTCLPSKS;WLQGTDFMPDSC 3 11 0.99376 -0.16494 0 0 0 0 0 0 0 0 0 0 9.55052 0 0 13.2207 0 A0A8P0NDY4 A0A8P0NDY4_CANLF Regulation of nuclear pre-mRNA domain containing 2 RPRD2 Canis lupus familiaris (Dog) (Canis familiaris) GPSSASELASLGGGGS;SNLTQPSLTATDQQQ 2 2.2 0.93609 0.098031 0 0 10.8638 0 0 0 0 0 0 0 0 10.0039 0 0 0 A0A8P0NDY9 A0A8P0NDY9_CANLF Chromosome 4 C1orf198 homolog C4H1orf198 Canis lupus familiaris (Dog) (Canis familiaris) AAAIAASRS;GGGAGGGR;GGGGGRPG;RPGGGAGA 4 4.8 1.0038 -0.80421 3.98121 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NDZ6 A0A8P0NDZ6_CANLF V-set and immunoglobulin domain containing 8 VSIG8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCCCGGAGA 1 2.2 1.0035 -0.80421 8.67835 6.9982 7.40667 8.82836 8.55082 9.01313 6.83302 8.00017 7.16702 0 8.70732 7.65184 8.5694 7.02879 7.6211 A0A8P0NDZ8 A0A8P0NDZ8_CANLF Kinesin family member 7 KIF7 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ALEKELGRHM;DIQLREDDRGNV;EEPATQGPGGPKVAKGQDEE;ETLNTLNY;LEVYKEEF;LVSKFHFVD;QQKEHEQNIQLL;SHALGVVL 8 6.2 0.99677 -4.6834 0 0 0 0 9.79899 0 10.2289 14.843 12.7045 0 0 9.54558 0 0 8.86719 A0A8P0NE23 A0A8P0NE23_CANLF Ig-like domain-containing protein MCAM Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ETDGDRGVGKVL;LVEVEVGGTALLKC;SRCSSPTLQKGCPARRQASSL 3 6.6 0.99091 -0.18559 6.17778 0 0 0 0 0 7.04144 0 0 0 5.915 0 8.86273 0 7.54063 A0A8P0NE25 A0A8P0NE25_CANLF ATP binding cassette subfamily C member 9 ABCC9 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transport [GO:0006813] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; sulfonylurea receptor activity [GO:0008281] AQMEDEDEEEEEEEDEDDNMS;DEEEEEEEDEDDNMSTV;DGSVLREGTLKDIQTKD;EDEDEEEE;EDEDEEEEEEEDEDDNM;EDEDEEEEEEEDEDDNMS;EDEDEEEEEEEDEDDNMSTV;EDEEEEEEEDEDDNMS;EINVIRVRRYVFFMNP;GVSDLRFCITGM;IVFLDDPFSALD;KTCWRYLTSGGF;LSAANRWLEVRT;MGEMTLGQINNLVAIETNQ;NLDPECKCTD;VGQRQLFC 16 9.8 1.0021 -0.98883 9.75974 11.6602 0 0 8.88548 0 10.0239 4.87666 10.3016 0 0 0 6.96659 8.06005 7.47143 A0A8P0NE29 A0A8P0NE29_CANLF cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] cAMP binding [GO:0030552] DNFYVIERGTYDILVTKDNQTRSV;DPRVIHPK;REARLQASSPPAAPPSGSQGLEPSP;SEDDEDLDVCAETYN 4 18.5 1.004 -1.073 0 0 0 0 0 0 0 0 12.5001 0 0 0 0 0 9.43365 A0A8P0NE47 A0A8P0NE47_CANLF C2 domain-containing protein SYT14 Canis lupus familiaris (Dog) (Canis familiaris) SIRRGQPNPVYK;VGEVGYTL;VHLVLLPIKKQRAKTSI;VLLPIKKQRAKTSIQRGP 4 5.2 1.0022 -0.95941 0 0 0 9.00776 0 0 0 0 7.00101 0 0 0 0 0 9.4528 A0A8P0NE56 A0A8P0NE56_CANLF THO complex subunit 5 THOC5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LVSLEEFYKEAPPD;VLLDVYLETESHD 2 4.1 0.99458 -0.19061 0 0 0 0 0 0 0 0 6.68958 0 0 0 0 0 9.30275 A0A8P0NE58 A0A8P0NE58_CANLF Importin 4 IPO4 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] AMLLEHAG;CQDTDEEEEEEDQAEYDAM;DAIRVRILCCLTFLVKVKSKALL;DEEEEEEDQAEY;EALGQFCCAL;FYSLRTLTTMA;IMEHLREFLLAGHGDLQPVQ;LTFLVKVK;VGSPGLLFYS;WSSSCGSCCCRTPS 10 9.8 0.99044 -0.26822 0 0 0 0 0 0 0 9.22132 0 0 0 0 0 0 0 A0A8P0NE68 A0A8P0NE68_CANLF WD repeat domain 93 WDR93 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] AELSRIQPVT;GVLTLWDLAE;GVLTLWDLAEGFPLGV;IAMPAEVKSPSGVACILG;LSTLEPVT 5 7.6 0.95343 0.049461 0 0 0 0 0 0 9.64405 0 0 0 0 0 0 0 0 A0A8P0NEA2 A0A8P0NEA2_CANLF Wiskott-Aldrich syndrome protein family member (WASP family protein member) WASF2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin binding [GO:0003779] EFDEDDWSD;RVSSLAERVDRLQV;VGNDVATILSRRIAVEYSDSED 3 9.1 1.0009 -0.62517 0 0 0 0 9.87432 0 0 0 0 0 0 0 0 0 0 A0A8P0NEB0 A0A8P0NEB0_CANLF Nuclear factor of activated T cells 4 NFATC4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] CEDEELEFK;FLPRPFPSD;QVHRITGKMVATA 3 3.4 1.0032 -0.87341 0 8.50545 0 0 0 0 0 0 0 0 0 0 0 0 9.1725 A0A8P0NEC1 A0A8P0NEC1_CANLF Cadherin 26 CDH26 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEIHPKSGV;ELDNSWGS;LLLLLLLL;LLLLLLLLL;LLLLLLLLQVNGV;LSLPLLSVLLLLLLLL;LSLPLLSVLLLLLLLLL;LSVLLLLLLLLLQ;NEEPLFPCEGGQ;PLLSVLLLLLLLLLQVN;SLPLLSVLLLLLLLLLQ;SLSLPLLSVLLLLLLLLLQ;SVELLMSRSLPPGNYSVPLFIGD;TLELEEEDQGP;VLLLLLLLL;VLLLLLLLLLQVNGVNSFQQE 16 11.2 1.0043 -2.0051 0 5.3989 0 0 10.1565 4.19409 0 8.74221 7.52951 9.37517 8.8743 9.04459 9.87903 6.14286 9.48424 A0A8P0NED2 A0A8P0NED2_CANLF Kelch like family member 30 KLHL30 Canis lupus familiaris (Dog) (Canis familiaris) LVGDNTKKVYVYD 1 2.2 0.93634 0.074987 0 0 0 0 0 0 0 11.4685 0 0 0 0 0 0 0 A0A8P0NEE3 A0A8P0NEE3_CANLF KIAA2012 KIAA2012 Canis lupus familiaris (Dog) (Canis familiaris) AISAWTPE;IFPVEIHFHTQNP;KEGSSIQRPLRT;PKGHRKRPGLEL;QQEEAKRAEVERQ 5 4.9 0.98785 -0.35003 0 10.6174 0 0 9.1153 0 0 0 0 8.46508 0 8.41604 0 0 0 A0A8P0NEE9 A0A8P0NEE9_CANLF "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4" PFKFB4 Canis lupus familiaris (Dog) (Canis familiaris) "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" 6-phosphofructo-2-kinase activity [GO:0003873]; ATP binding [GO:0005524] EFNVGQYRR;EQLPYLKCPLHTV;GVCEEMTYEEIQDHYPLE;MRRIECYENSYESL;VGQYRREMVKTY 5 13.1 1.0018 -0.74954 0 0 10.8489 7.81012 0 0 0 11.9857 0 0 0 9.84967 0 0 0 A0A8P0NEF5 A0A8P0NEF5_CANLF [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) NDST3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213] CINPHSPLLH;LVFVESQYSSLGQ;NPHSPLLHV;PDQKDPLWQNPCDDKRHRDIWSK;PKRAASLVPKAKIITILI;QENEPSEMMSEVDC;QPVIFAKVKTPENLS;SYYRDHNVEL 8 12.8 1.0032 -2.4004 11.3117 0 0 12.5886 0 9.41026 0 10.111 0 8.62772 0 0 0 0 13.527 A0A8P0NEG0 A0A8P0NEG0_CANLF Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome organization [GO:0007031] peroxisomal membrane [GO:0005778] GEKKKKKKKK;KKKKKKKK;LVQRFPARKEE;PHLVEQFQKLSEAAGRVGS 4 10.4 1.0027 -0.79084 10.6391 0 0 0 0 0 10.8099 0 0 0 0 0 0 0 0 A0A8P0NEG1 A0A8P0NEG1_CANLF Coatomer subunit alpha COPA Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] IVSGADDRQV;KFPVFNMSYNPAE;PPGAAGGA;SEDKSIRVW;TAMRLLHDQVGVTQF;VLAAHPNLN 6 5.5 1.0024 -1.2272 6.78333 0 0 0 0 5.80054 7.80491 0 0 0 0 0 9.79357 0 0 A0A8P0NEH5 A0A8P0NEH5_CANLF Arginyl aminopeptidase like 1 RNPEPL1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] LDRLLDGS;LYGPYMWGRYDIVFL;MWGRYDIVF;PALLLGDEAPSSA;PALLLGDEAPSSAIS;SYVEEEGVYRF;YLSQLCGDPQRFDDF;YMWGRYDIVFLPP 8 13.4 1.0029 -0.85393 14.6344 0 0 0 0 12.0541 0 11.9511 11.8686 15.1547 11.8284 15.2043 14.9714 9.92898 10.9757 A0A8P0NEI9 A0A8P0NEI9_CANLF "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase)" ALG3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] mannosyltransferase activity [GO:0000030] EALFLHRAFHVALLAAH;PAFPQERPAQQ 2 6 0.99242 -0.051517 0 0 0 0 0 0 0 0 7.19387 0 0 0 0 0 0 A0A8P0NEK0 A0A8P0NEK0_CANLF Eukaryotic translation initiation factor 4 gamma 1 EIF4G1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] DFIPSFANVGRPALSNRGP;EAGLSWKEFLP;EPNFSVAYA;ESLECLCRLL;GELEITKPLRPLGKAASLLL;KLLLNRCQKEF;LDRSRTPAT;VAYANMCRCLM;VVFSTPQATQMNTPSQPRQ;YALQALVVTL 10 7.8 1.0029 -1.3445 11.6823 0 11.6832 0 9.61642 0 8.66359 5.88582 6.44253 0 0 11.2843 0 0 11.9796 A0A8P0NEK7 A0A8P0NEK7_CANLF Serine-threonine kinase receptor-associated protein STRAP Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] RIYDLNKPEAEPKE;VSLDPIKSFEAPATI 2 8.3 0.99297 -0.17187 9.84721 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NEK9 A0A8P0NEK9_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PASK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAEGLPMPYPGYGGEQSTQ;EDQRDIPGRSPP;GVTLYTLI;ILVANDKACQLLGHSSHA;IPGRSPPAHNQQ;LSTVSLELEGRCAGELAWAAGPG;WMFASQGG 7 6.6 1.0032 -1.0282 0 0 9.71206 0 0 0 0 0 0 0 0 0 0 3.68077 0 A0A8P0NEL2 A0A8P0NEL2_CANLF Superoxide dismutase copper chaperone CCS Canis lupus familiaris (Dog) (Canis familiaris) superoxide metabolic process [GO:0006801] copper ion binding [GO:0005507] AGTDGRAIFRIEDE 1 5.3 0.93108 0.096481 0 0 11.675 11.5309 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NEL7 A0A8P0NEL7_CANLF Chromosome 28 C10orf120 homolog C28H10orf120 Canis lupus familiaris (Dog) (Canis familiaris) DEDDEADFYDDAKQ;DLMLMNQDFISRGV;EDDEADFYDD;LEIWTKFYKSDP;SLSSNYKRVMEY 5 15.6 1.0028 -0.98557 0 0 0 10.3806 9.66846 0 0 0 10.7054 0 2.79776 0 0 0 9.63145 A0A8P0NEM9 A0A8P0NEM9_CANLF Plexin B1 PLXNB1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] AAQKMQLGYRLQQ;EADPSAALLDQPPGTA;EFTVQMGNLRFS;GVIIIVLIYRRKS;GVIIIVLIYRRKSKQ;GVIIIVLIYRRKSKQALRD;KYTLNDNRLLRED;PESRRPTVEQGLGQ;PWVQVEFILDNLVFDF;VPGERTPMLEDVDEGGIRPWHL;WCVWQQLC;YINKYYDQIITALEE 12 6.9 1.0033 -1.5573 7.71218 8.00338 4.8533 11.1022 0 9.65607 0 0 4.12838 0 6.98618 5.43152 0 0 0 A0A8P0NEN1 A0A8P0NEN1_CANLF Striatin 3 STRN3 Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; protein-containing complex binding [GO:0044877] DLSPPTEVWDV;GGGGGGPG;IYDLETSQSLVML;LENADDSDEEEENDMI;PNGSVETKNLEQILNGGES;TAHEDRHIKFFDNKTGKM 6 11.3 0.98654 -0.42508 0 0 0 0 0 0 9.21524 0 8.84577 0 0 0 9.33239 0 0 A0A8P0NEN6 A0A8P0NEN6_CANLF Deleted in malignant brain tumors 1 protein (Hensin) Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; protein transport [GO:0015031] membrane [GO:0016020] AHFGPGSG;DGWQVASLSVGRFCAGTE;GGTGHIML;IMTVVFRSDAMI;IPYGRCGTVRQESLGSLG;PQGEGEPENGPE;VWMIQVAEKFHIE 7 7.4 0.99137 -0.27585 0 0 0 0 9.09231 0 0 0 0 0 0 0 0 0 0 A0A8P0NER6 A0A8P0NER6_CANLF Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C2G Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol-mediated signaling [GO:0048015] 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; phosphatidylinositol binding [GO:0035091] ASLTLPEFPHWWHLPFTN;DVKNICSVLGCVETKQITD;ELCCQAYNIVR;HSHLSFTVYAVHNIPETWVHRINFP;LNDELLEYLPQ;LPLVLGSAPGWDV;QTIEESSLLDLGE;TAFPYQLFSN;YCCSFYAD 9 8.9 1.0032 -2.3648 0 10.1763 7.45681 10.7635 0 10.4483 11.0756 8.22342 10.3647 0 8.13484 0 7.3658 0 7.49737 A0A8P0NES8 A0A8P0NES8_CANLF DDB1 and CUL4 associated factor 7 DCAF7 Canis lupus familiaris (Dog) (Canis familiaris) LEHSTIIYEDPQHHPLLRL 1 5.6 0.95272 0.049538 6.79753 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NEU1 A0A8P0NEU1_CANLF "Mucin 4, cell surface associated" MUC4 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] membrane [GO:0016020] AWMFGDPHITTLDG;LFHYGMTW;LPAEYRGRTEGLL;RCLVAGNPFTPAAPA;TLYREHNLLVQQVESWINKFTD 5 6.4 0.98491 -0.25747 0 0 0 0 0 0 0 0 0 0 0 0 11.5975 0 0 A0A8P0NEU3 A0A8P0NEU3_CANLF RNA helicase (EC 3.6.4.13) HELZ2 Canis lupus familiaris (Dog) (Canis familiaris) "3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]" CHSQEAFENHCSSLEHAQ;GHTLLYRLFQHYQREAH;GKARKFELD;LGFRAAHVMIKEYMIQ;PEDPEDTESDFWPSDTE;PVLLRKLRL;TEAILSFV;TELNADDSILQ;VGVLKRKRREL;VGVLKRKRRELV;VHIADVASSLP;VILCTCSCAASASL;VLQYCCLTQDRRAFRAPTRAELEQH;VLSTVHNHHSLL;VRIVLWRQR 15 6.3 0.97903 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 8.20877 0 0 A0A8P0NEV4 A0A8P0NEV4_CANLF Centrosomal protein 164 CEP164 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] ANKKEVPENPVD;DEAKKEHTHLLESNQQ;DVLEHPQEMALASAGQEASQQ;EAEERKQRTELLGHLTRE;EANRKWLE;ESPGLWMRQVSKLVNKDPPG;LDVDVLSP;MLEQLKEEME;PAAIKKKDKKKK;QSVRSSSELLKNL;WGLDVLEHPQ 11 7.1 1.0034 -2.38 8.63941 0 0 3.77357 8.10512 10.9253 8.56491 8.81586 0 11.1164 0 11.6898 10.1205 0 0 A0A8P0NEW2 A0A8P0NEW2_CANLF Zinc finger and BTB domain containing 46 ZBTB46 Canis lupus familiaris (Dog) (Canis familiaris) ARAAPFRVYVTQTY;NSSGDSAIASCHEGGSSYGKEDQE;PSGPCTCTQSPGCP 3 8.8 0.98762 -0.50163 0 7.81198 0 0 0 0 0 8.95303 0 0 0 9.03884 0 0 0 A0A8P0NEW6 A0A8P0NEW6_CANLF Centrosomal protein of 19 kDa CEP19 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] GNSLYSHVAGTTA;RRPKSLPCR 2 6.1 1.003 -0.73288 0 0 0 8.55543 0 0 0 4.08534 0 7.23074 0 10.5032 0 3.76797 4.33435 A0A8P0NEX6 A0A8P0NEX6_CANLF Phosphodiesterase (EC 3.1.4.-) PDE8A Canis lupus familiaris (Dog) (Canis familiaris) cAMP catabolic process [GO:0006198]; regulation of DNA-templated transcription [GO:0006355]; signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" LMACYNELLQ;MLIKCADVSNPCRPLE;NIINAAQESSPMPVTEAL;QSDTHTDN;TECVQSDTHTDN 5 7.4 1.0033 -1.5597 6.68846 0 0 2.90458 0 0 0 0 0 0 0 0 0 14.5368 0 A0A8P0NEY8 A0A8P0NEY8_CANLF "NUBP iron-sulfur cluster assembly factor, mitochondrial" NUBPL Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] "4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; metal ion binding [GO:0046872]" KYGLLRILIKPL;VTLRGGGGAGVPLGGS 2 9.4 0.93391 0.099673 0 0 0 7.16249 0 0 0 0 5.63865 0 0 0 9.69378 0 0 A0A8P0NF19 A0A8P0NF19_CANLF Tripartite motif containing 50 TRIM50 Canis lupus familiaris (Dog) (Canis familiaris) LVPRILRC;VWKRLFRKVLPAP 2 4.1 0.99026 -0.20213 0 0 0 0 0 0 0 8.56415 0 0 0 0 0 0 0 A0A8P0NF25 A0A8P0NF25_CANLF Zinc finger protein 365 ZNF365 Canis lupus familiaris (Dog) (Canis familiaris) DISEHVLTDISSNRKPKC;ELLRKEEEVVTFNHF;LSRGHPHPVC 3 10.5 1.0023 -0.7569 0 0 0 0 0 0 0 0 9.50299 11.8388 0 0 0 7.7486 0 A0A8P0NF37 A0A8P0NF37_CANLF NAD(P)(+)--arginine ADP-ribosyltransferase (EC 2.4.2.31) (Mono(ADP-ribosyl)transferase) ART4 Canis lupus familiaris (Dog) (Canis familiaris) NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779] HSFHFKYLHYYLT;IWLLPRQLPLL;LLKGSGKK 3 9.8 0.9926 -0.16764 0 0 10.413 10.3709 0 10.0355 0 9.34727 0 0 0 7.1179 0 9.88258 0 A0A8P0NF64 A0A8P0NF64_CANLF "Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2" TANC2 Canis lupus familiaris (Dog) (Canis familiaris) synapse [GO:0045202] IPESELGSPTLASAQ;SSAYRGGMRYS;VTSPTSTLESRDSGI 3 2 0.98615 -0.45291 0 0 0 0 0 11.3916 0 0 0 0 6.86109 0 0 0 0 A0A8P0NF77 A0A8P0NF77_CANLF Cell adhesion molecule 1 CADM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AILHEGDGQNLFTKDV;EVATISCQVNKSDDSVIQL;LTREGDAFE 3 9.8 0.95526 0.049233 0 0 9.13417 0 0 8.52493 0 0 0 0 9.15086 0 0 0 0 A0A8P0NF78 A0A8P0NF78_CANLF Large subunit GTPase 1 homolog LSG1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LEEEQKLL;SDVTTSDEDASEYEDCQEEEEEVW;SLSDVTTSDEDASEYEDCQ;TSDEDASEYEDCQEEEE;VTTSDEDASEYEDCQ 5 5.2 0.98709 -0.3792 6.96139 6.20621 0 0 0 0 0 0 5.95884 0 0 11.8681 0 0 0 A0A8P0NF89 A0A8P0NF89_CANLF Signal-induced proliferation-associated 1 SIPA1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] CRAGQGSEEEMYN;ELATNEVTTTSLDSASRFGLPSL;VCLHDGGIPTGP;VVFNCACRDVLAWTFS 4 6.1 0.98735 -0.40396 0 0 0 0 0 0 0 0 0 0 8.15527 0 8.11634 0 10.4418 A0A8P0NFB0 A0A8P0NFB0_CANLF Crossover junction endonuclease MUS81 (EC 3.1.22.-) MUS81 Canis lupus familiaris (Dog) (Canis familiaris) DNA catabolic process [GO:0006308]; double-strand break repair via break-induced replication [GO:0000727] Holliday junction resolvase complex [GO:0048476]; nucleus [GO:0005634] crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] GELVLDHIVERKRL;VLRTHQPARYSLTPEGLELA 2 6.8 0.9914 -0.27275 0 0 0 0 0 6.10419 0 0 0 0 0 0 0 0 0 A0A8P0NFB9 A0A8P0NFB9_CANLF PAT1 homolog 2 PATL2 Canis lupus familiaris (Dog) (Canis familiaris) deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290] cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] AIDAVPHGSQE;SSQRLQVLSRIEKMFLQLL;VLSVRKGKALVARL 3 12.4 0.85774 0.14603 0 0 4.75168 0 0 0 9.62659 0 8.47025 0 2.81098 0 0 0 0 A0A8P0NFD7 A0A8P0NFD7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDEADYYCQSYDSSGNVHS 1 12.2 0.99079 -0.26949 0 0 0 0 0 11.3445 0 0 0 0 0 0 0 0 0 A0A8P0NFE2 A0A8P0NFE2_CANLF RUN and FYVE domain containing 2 RUFY2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DAAGGRGAAMRRGT;EKEWRQTLQEDLQ;ENKLILMKTQQHL;FQVWGWRREDAPQVLAWVPD;KLQEENHQ 5 10 1.0018 -1.8184 0 0 8.74873 0 0 0 9.12789 9.71261 0 0 0 0 0 8.85686 10.3488 A0A8P0NFE4 A0A8P0NFE4_CANLF Transmembrane inner ear TMIE Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KPPPLTKE;LNELTEIPGEDK 2 13.3 0.98998 -0.50977 0 0 10.3776 0 0 0 0 0 8.89163 0 0 0 0 0 0 A0A8P0NFF1 A0A8P0NFF1_CANLF C-type lectin domain family 12 member A CLEC12A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] signaling receptor regulator activity [GO:0030545] LMYCGYVDIPFV 1 4.5 0.9564 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.03707 A0A8P0NFF8 A0A8P0NFF8_CANLF Mex-3 RNA binding family member B MEX3B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] RNA binding [GO:0003723] GGGGGGGE;GGGGGGGG;KALRAKTNTYIK;NNNGNGYTYAAGE;PLHMAPGA;TIKRIQQQTHTYIVT;VFPGGGAG 7 12 1.0026 -1.49 0 0 0 0 0 0 8.75806 0 0 0 9.80924 0 0 0 8.98596 A0A8P0NFG5 A0A8P0NFG5_CANLF "GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)" AK3 Canis lupus familiaris (Dog) (Canis familiaris) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041] mitochondrial matrix [GO:0005759] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899] TDTVINLNVPFEVIKQ 1 7 0.95553 0.049233 0 0 0 0 0 0 0 0 0 0 0 4.28503 0 0 0 A0A8P0NFJ0 A0A8P0NFJ0_CANLF Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) CAPN1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] AEEIITPVYCTGVSAQVQ;NAIKYMGQDFEQLRAH;RFGRDMETIGFAVYEVPPE;TELLSNPQ 4 9 1.0011 -0.93334 10.1789 0 0 0 0 11.8268 0 0 0 0 0 0 0 11.2936 0 A0A8P0NFJ2 A0A8P0NFJ2_CANLF Solute carrier family 5 member 4 SLC5A4 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] RLFIILLIV;SEKELLIAGRLFIILLIVISIL 2 3.6 1.0026 -0.75752 6.48294 0 0 0 0 0 0 0 7.14486 0 0 0 0 0 5.0909 A0A8P0NFL0 A0A8P0NFL0_CANLF Acyl-CoA binding domain containing 4 ACBD4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] fatty-acyl-CoA binding [GO:0000062] QESMRDVQGRLQSLESMP;SGPTLLFF;TFLRRVTGW 3 11.6 0.98701 -0.37975 10.9402 0 0 3.78136 0 0 0 0 0 0 0 12.1381 0 0 0 A0A8P0NFM6 A0A8P0NFM6_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLSCSDTWLLE 1 4.9 0.99309 -0.13976 5.45111 0 0 0 0 9.94355 4.39087 0 0 0 0 0 11.4428 4.74561 0 A0A8P0NFQ0 A0A8P0NFQ0_CANLF Forkhead box A1 FOXA1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; sequence-specific DNA binding [GO:0043565] GAGGGGGG;GGGGGGGA;GGGGGGGG;GVHGKAGQLEGAPGPGP;IYQWIMDL;PDKPGKGSYWTLHP 6 12.5 0.99217 -0.14202 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.05523 A0A8P0NFQ3 A0A8P0NFQ3_CANLF KAT8 regulatory NSL complex subunit 1 like KANSL1L Canis lupus familiaris (Dog) (Canis familiaris) H4 histone acetyltransferase complex [GO:1902562]; intracellular membrane-bounded organelle [GO:0043231] IVILEDCQLPKDI;LNQWRNGYSPTCKPQIR;SLKHQLPQMKTFHEPTTVLDSSL;WSLWEQSKWHRRNSRAYSKNVEGQ 4 7.8 1.0041 -0.82692 0 0 11.7241 0 0 0 0 7.98641 0 0 0 0 0 0 10.6402 A0A8P0NFQ8 A0A8P0NFQ8_CANLF Acetylcholinesterase (EC 3.1.1.7) ACHE Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886]; synapse [GO:0045202] cholinesterase activity [GO:0004104] GGGGGGGG;GPARLGRLRRLPALAAMRPP;LVSMNYRVGAFGFL;TVGGGGGG;VGCPPGGAGGNDTELVACLRTRPAQ;VGGGGGGG;VGGGGGGGG 7 8.7 1.0025 -1.1246 6.55851 0 0 0 0 0 16.2096 0 10.9861 8.87132 0 0 7.34305 0 0 A0A8P0NFT3 A0A8P0NFT3_CANLF Cation-transporting ATPase (EC 7.2.2.-) ATP13A4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type ion transporter activity [GO:0015662] GVLPCDRSGFQEVHSFAS;KEGRAALVTSFCMFKYMA;PFYIFQLFSVC;VYDLREQSIKL 4 5 0.98789 -0.46962 0 0 9.0018 0 8.46989 8.25715 12.82 0 0 0 0 10.0246 0 0 0 A0A8P0NFT6 A0A8P0NFT6_CANLF Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein) SACM1L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphatase activity [GO:0016791] EGHAANFVETEQIVHY;KYFDWILISRRSCFRAGVRYYVR;QKEKMDICVCGKRLGLE;YVAFDFHKECKNMR 4 11.5 0.81591 0.20269 0 0 7.01223 0 0 0 0 0 0 0 5.8214 0 0 9.62613 0 A0A8P0NFT9 A0A8P0NFT9_CANLF Integrin subunit alpha 4 ITGA4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] AVLLRTRPVVIVEVSL;GAVRELLLLLLLLCLR;IILSSLLLGLILLLLIS;LLLLLLLL;LSSLLLGLILLLLI;RQYKSILQEENRRDSWSYVN;SVKLDCSIGYIY;TIAIILSSLLLGLILLL;VGAPMQSTIREEGRVFVYINSGSGA 9 10.6 0.95491 0.049233 0 0 0 0 0 0 0 0 0 0 4.94143 0 0 0 0 A0A8P0NFU2 A0A8P0NFU2_CANLF Kelch domain containing 2 KLHDC2 Canis lupus familiaris (Dog) (Canis familiaris) FVFGGRYRDARMNDLHYLNLDTW;LSFSFVSPALAGV 2 5.9 0.99216 -0.20676 0 0 0 0 0 0 0 10.2 7.72928 0 0 0 0 0 0 A0A8P0NFU5 A0A8P0NFU5_CANLF Menin MEN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] HRCSRPAGLRFC;PAGLRFCP;YHCRNRNVREAL 3 3.6 0.99553 -0.015997 0 0 9.1601 0 0 0 0 0 0 0 0 0 8.89588 9.27296 9.96356 A0A8P0NFV0 A0A8P0NFV0_CANLF 3CxxC-type domain-containing protein RTP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HNVLAPGW 1 3.1 0.98518 -0.25792 0 0 0 0 0 0 0 0 0 0 0 0 9.53025 0 0 A0A8P0NFW4 A0A8P0NFW4_CANLF Retinitis pigmentosa GTPase regulator SRPX Canis lupus familiaris (Dog) (Canis familiaris) EQPESVEFSSG;IDGIPMPPVCFSPSPIP;IKSLIKKLLCRL;KSLIKKLLCRLRH;RIKSLIKKLLCRLRHPLVL;SDNSLKKDETTK;SEDEEPEDMAEE;SLSNLSSGIVLHQ;VLNDSESTPN 9 8.7 0.98503 -0.4312 4.48214 0 4.57658 4.13142 0 0 0 0 0 0 0 0 10.1244 0 5.22145 A0A8P0NFY5 A0A8P0NFY5_CANLF Distal membrane arm assembly component 2 like DMAC2L Canis lupus familiaris (Dog) (Canis familiaris) ERWQKDYNNLP;VGPDRAASEWLLRC 2 22.3 0.99148 -0.27622 0 0 0 0 0 0 0 0 10.1753 0 0 0 0 0 0 A0A8P0NFY8 A0A8P0NFY8_CANLF Tenascin N TNN Canis lupus familiaris (Dog) (Canis familiaris) ATVSWDPV;CDTGECYCEEGFSG;CRCHEDFTSEDCS;DTGECYCEEG;ECYCEEGFSGLDCAH;IDSPTNLATDRV;LAVLGTAWVTDET;RCPGDCSG;RCPGDCSGHGFCDTGECYCEEGF;VGKYRGTAGDAL;VPVGKEQRSTVL 11 11.6 1.0035 -2.0312 5.14405 6.97911 12.9755 7.18755 0 0 10.5069 0 9.98812 0 0 0 5.98932 0 9.81453 A0A8P0NFZ9 A0A8P0NFZ9_CANLF Calcineurin binding protein 1 CABIN1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] AARCEGDGDEEE;DQGKKYLRDADRQ;EAQEAEAFALYH;EAQEAEAFALYHKALDLQKHDRF;EPDLKLVQ;ESSLESETDEEDDYM;EVMAETPMLPSSL;FASSQRDL;IVLLLKVLAQL;LPSSLMLLNTAHEYLG;PADALQRPSD;PDLKLVQP;PELVQQMEGRRDSMLE;RLHASILKLL;SIVLLLKVLAQLR;TVEDDHEGSFKSH 16 7.8 0.99737 -3.8622 0 5.84366 0 0 9.94182 4.79135 9.01578 7.55005 0 9.28174 6.79468 11.8166 11.1252 5.11724 4.22974 A0A8P0NG07 A0A8P0NG07_CANLF G protein-coupled receptor 137 GPR137 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DYDWYNVSDQADLVNDL;LLVRVLVSDSLFVICALSLAAC;VHRPPQDLVFGS;VPAAGLVP 4 15.2 1.0025 -1.1644 15.1726 15.2232 0 0 0 0 15.1337 14.3327 0 0 9.15125 0 0 0 10.4025 A0A8P0NG19 A0A8P0NG19_CANLF MAGUK p55 scaffold protein 2 MPP2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] AGEHLGVTFRVEG;KRKAFVKRDLEL;LDNLGSLPNATG 3 7.4 0.98708 -0.36487 4.00737 0 0 0 0 9.51363 0 0 0 0 0 9.37152 0 0 0 A0A8P0NG22 A0A8P0NG22_CANLF Fibrous sheath interacting protein 2 FSIP2 Canis lupus familiaris (Dog) (Canis familiaris) CPGVAPDD;DKISNFVYDQFMGKYRSSDIQ;DSHLLTSFERCTKIS;EDSILSSDSSSFCSTCSE;EDTTRLSDQQPMTDPT;FLEDVITEMVNKLIFSSSSETQI;FPPIDKETVDKI;FYSLPSITEDSK;GFNLNDPYCRLLENQYKS;IRFSKNEETKLVY;ISAQNSVVSPQTSPTRNCPKSSPS;IVSQLMKSVTAEISQSNIN;KESEGSDIFVENI;KIVKNVLDSSFR;KVISAISKHKILFTI;LEDIIRRLLSQLIPLPNKAS;LENKCLQYSPSQVGKDLVQMV;LSHSFLEDIIRRLLSQLI;LSINAKNPTSARLP;LVEEALALFLAKIVR;LVPSSFSSPQADNI;NLGLTPKSVFLLN;QAESNDMENEKYKLMMIAENVLTEI;QEVSGNQLQNYFSGELTPHQC;QFTKGNTCFEY;RKDILRRLKKGGYITSNN;RLKKGGYITSNNKEMLA;SSFCSTCSEEFTYGSYTSATT;STKSSQSL;TVTMVLQELYATSNH;VINEIFQHQLN 31 6.7 1.0032 -2.434 10.9394 10.6502 10.7782 8.65975 9.90722 7.88289 7.97842 10.4291 13.3875 0 10.2016 10.7327 10.5506 10.786 7.76779 A0A8P0NG25 A0A8P0NG25_CANLF tRNA (uracil(54)-C(5))-methyltransferase (EC 2.1.1.35) TRMT2A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; RNA processing [GO:0006396] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] AIVYFHPQVS;DGGGARGS;PHAFFQVN;QPGLYSYIRDD;VLDVCCGTGTIGLALA;VLQKLAKEI 6 9.8 1.0021 -1.8243 8.42819 0 0 0 9.29076 0 0 0 0 0 7.27473 0 0 0 11.4488 A0A8P0NG51 A0A8P0NG51_CANLF Potassium two pore domain channel subfamily K member 4 KCNK4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] APGRAMRSTTLLALLALVLLYLVS 1 5.7 0.97382 0.041303 0 0 0 0 0 0 0 0 0 4.06772 0 0 0 0 0 A0A8P0NG56 A0A8P0NG56_CANLF Prosaposin PSAP Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665] extracellular region [GO:0005576]; lysosome [GO:0005764] ICGLVGFCEQAKEM;LHLCSSQGLPVLPV;MMHMQPKEICGLVG;PVILDMIKGQMSHP 4 9.6 1.0026 -1.1423 0 0 0 9.24835 0 0 0 0 0 0 0 9.52556 0 0 0 A0A8P0NG58 A0A8P0NG58_CANLF FERM domain containing 6 FRMD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] HYYRLYKD;LVDDPRDLEQMNEESLEV;VLRHIRKLE 3 5.7 1.0027 -1.3859 0 0 0 0 0 0 0 6.83971 0 5.76975 6.34318 0 0 0 0 A0A8P0NG69 A0A8P0NG69_CANLF ATP binding cassette subfamily A member 12 ABCA12 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDALDDLVS;EQNSTSEDIRRKLC;GTYGMAAPWYFPVLPSYWKE;LEEVFINFAKD;LFKGSGIQ;LLVTIIILIIILK;LQNTLRNPFVQVFVKF;LSSLTVNISSCVLY;LVSVEEHLYFYARIHGI;LVTIIILIIILK;LVTIIILIIILKFGNILPKTNGFI;NSCPGPGS;QGTMFFFLRLLINEWLIKKLRLFFR;QMNYLENITQLMP;QWENMYSSPVQDD;SIDLIDHLN;SRQSYLIGLTLL;TSEDIRRKLCESY;VEELKEELRRTTGM;YPDYITRYAFSWTTLG 20 9.5 1.003 -2.2878 13.4677 0 0 7.69794 10.7581 9.0354 0 10.2961 0 11.3811 8.43329 9.06848 0 0 9.15876 A0A8P0NG87 A0A8P0NG87_CANLF ArfGAP with FG repeats 2 AGFG2 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] KGPGPGGG;KKGPGPGG;PDSRDPQKVKEFLQ;PDSRDPQKVKEFLQEKYEKKRWYVP 4 7.1 0.98573 -0.43524 13.0505 12.5856 0 0 10.2161 10.0593 12.6058 13.2615 12.6575 0 5.8134 0 0 0 0 A0A8P0NGB2 A0A8P0NGB2_CANLF guanylate cyclase (EC 4.6.1.2) GUCY1A2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] SNPGNCSC 1 1.2 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 4.67231 0 0 0 A0A8P0NGC7 A0A8P0NGC7_CANLF Cullin-5 CUL5 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] AECQGMIKRNETE;EEHIISAGL;EENEGIVQLRILR;FTEGTLFSVNQEFSLIK;ISADSEIEENMV;MVLRNQDLDARNKGSLQFEDKWDF;VLLYEPQVNSPKD 7 13.6 0.98728 -0.32009 10.8196 9.80793 13.4188 0 8.01792 0 13.8239 7.54828 0 0 0 8.75251 0 0 13.6536 A0A8P0NGD3 A0A8P0NGD3_CANLF LDL receptor related protein associated protein 1 LRPAP1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783] heparin binding [GO:0008201]; low-density lipoprotein particle receptor binding [GO:0050750]; receptor antagonist activity [GO:0048019] IKEDVLHSKH;KLSELHADLKMQE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLVGPRTA;LLLLLLLLLV;LLLLLLLLLVGPRTA;LPAPPLLLLLLLLLLVG;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPLLLLLLLLLLVGPRTAAGH;REKNEPELPPKRESGGEFR;RGLLPAPPLLLLLLLLL;RGLLPAPPLLLLLLLLLLVGPR;SRGLLPAPPLLLLLLLLLL;SRGLLPAPPLLLLLLLLLLVGP 19 19.2 0.99674 -0.099398 6.72765 7.00675 0 0 0 0 5.98035 7.03958 7.37138 0 0 4.43803 0 7.95925 9.24944 A0A8P0NGD9 A0A8P0NGD9_CANLF Calcium uniporter protein MCU Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial calcium ion homeostasis [GO:0051560] mitochondrial inner membrane [GO:0005743] calcium channel activity [GO:0005262]; uniporter activity [GO:0015292] QQLYTTLCI;YMATQFGILARLTWWEYSW;YTTLCIEQHQL 3 11 0.98923 -0.51904 0 11.4664 0 0 0 9.1502 0 11.3567 0 0 0 0 0 0 0 A0A8P0NGE6 A0A8P0NGE6_CANLF Pyroglutamyl-peptidase I PGPEP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234] TVQRLIPAL 1 8.1 1.0038 -0.80421 0 0 0 0 0 4.18531 0 0 0 0 0 0 0 0 0 A0A8P0NGF7 A0A8P0NGF7_CANLF Tubulin tyrosine ligase like 4 TTLL4 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] EDCCSHDENE;EDCCSHDENEE;GLEDCCSHDENEE;IHKWSQLPKRRPLLVQ;KMYVRRPYSCHEL;LEDCCSHDENE;LPTAEDIVSSSG;PARDISSAADLQPDL;QLPKRRPLLVQRYLHKPYLIS;RWKMSTVTPN;VDGLEDCCSHDENEE;VIHKWSQLPKRRPLLVQR 12 7.7 1.0033 -1.3354 4.43449 13.4189 0 6.59597 5.37532 7.55275 10.6239 7.44278 0 9.09003 0 10.59 0 0 0 A0A8P0NGF8 A0A8P0NGF8_CANLF Zinc finger protein 394 ZNF394 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] THTGEKPYKCLECGE 1 2.7 0.94817 0.05391 0 0 0 0 7.18982 0 0 0 0 0 0 0 0 0 0 A0A8P0NGG5 A0A8P0NGG5_CANLF Transmembrane BAX inhibitor motif containing 1 TMBIM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IHPMPMHYGQGYDGEERAVSESFGP;TISSVYET 2 10.7 1.0024 -1.3993 8.98692 0 0 0 0 0 0 0 0 0 0 10.5334 0 0 0 A0A8P0NGL7 A0A8P0NGL7_CANLF Flavin-containing monooxygenase (EC 1.-.-.-) FMO4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" ENIDTVIFATG;GVSGLSSIKCCLDEDLEP;PSCVLNWIQ;SITKGARKIIV 4 8.8 1.0027 -0.79872 0 0 8.80297 0 7.39566 0 0 0 0 0 0 0 0 0 0 A0A8P0NGM5 A0A8P0NGM5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ARAF Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] AQPTAEQAQAFKNEM;HEAPSNRPLNEP;SVLWMAAEVIRMQDPNPYS;VLEDVPLTMHNFV;YYWEVPPS 5 11.2 1.0032 -1.7343 0 4.40939 11.0608 0 0 8.27015 0 10.4389 5.03311 0 5.01306 0 9.64079 5.46591 4.86562 A0A8P0NGN5 A0A8P0NGN5_CANLF RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (SCY1-like 1-binding protein 1) GORAB Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EQLTEHLCTIIQ;QTKDPFEPQRR 2 5.8 0.98767 -0.34976 0 0 0 0 0 0 0 0 0 8.59033 0 0 0 0 0 A0A8P0NGN8 A0A8P0NGN8_CANLF Olfactory receptor OR2AE1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MHSAGSKRNAFATCS;MWQRNQTFLADFILE 2 9.4 0.99444 -0.0598 0 0 0 0 0 0 0 9.14756 11.8561 0 0 0 0 0 0 A0A8P0NGP1 A0A8P0NGP1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] HRFSKVYSSSEFLAAQPTPTFAERS;HVYRERFPKATA;IVQLVRKLLIII;LGSEDEETNDEES;LKNMGPLPVDMARM;LLECLEFDPE;SEEVGFIVQLVRKLLI;SPCSPSLG;VGFIVQLVRKLL;VNFPFARR 10 8.2 1.0033 -1.6121 0 10.4619 0 0 0 0 5.04933 0 2.69319 0 0 6.32454 0 0 9.88611 A0A8P0NGR8 A0A8P0NGR8_CANLF Phospholipase A and acyltransferase 5 PLAAT5 Canis lupus familiaris (Dog) (Canis familiaris) EDVLHGCSWK;VGPAPSQG 2 7.1 1.0032 -0.87738 0 9.981 0 4.8903 0 0 0 0 0 0 5.10999 0 0 0 0 A0A8P0NGS6 A0A8P0NGS6_CANLF Transmembrane and coiled-coil domains 4 TMCO4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLANMVAQEALKYTVL;VGKHLAHI;VLPTMTAFAKGLGGEGADVFA 3 7.6 0.99109 -0.13513 0 10.1392 0 0 0 0 0 0 10.1369 0 0 0 0 9.62939 11.0235 A0A8P0NGT3 A0A8P0NGT3_CANLF AP-4 complex subunit epsilon AP4E1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] AP-4 adaptor complex [GO:0030124]; Golgi apparatus [GO:0005794] ESIKTFQYNVQMEKPFTDGNLTGFI;GKFVLSPKINLKYL;IIRRKAVLALYKFHLIAPNQVQHIH;VLSPKINLKYLGLKAL;YHSVPAPWLQ 5 7 0.81713 0.20468 9.11054 0 0 0 0 0 11.3811 6.0651 4.11128 0 0 0 0 0 0 A0A8P0NGU9 A0A8P0NGU9_CANLF Sodium channel epithelial 1 subunit alpha SCNN1A Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] apical plasma membrane [GO:0016324] sodium channel activity [GO:0005272] ATLSMARTTLTSGCLLCLGSKMEA;LLVITFLMLLRRFRSR;YSRWPSVTSQDWIFQM 3 15.2 0.97407 0.041303 0 0 9.07221 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NGW2 A0A8P0NGW2_CANLF Zinc finger protein 518B ZNF518B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] EDAHIIEATCEA;FKCWFCGRLYEDQEEW;GRNLHGDL;GVKWNSSTSKIKSIELLRRKIAQLI;LKDKQMEEHKAVSNTSQIS;MKLKKVHKNNYQVV;SRFSLHTNKDKMHSIMLLPESKE;SSKKKSKI;VINKYKGNVLKVVL;VKCKSVHKI 10 13.7 1.0035 -1.6071 0 12.3995 0 0 7.59081 0 10.102 10.1366 0 0 0 13.3508 10.0625 8.71713 3.37518 A0A8P0NGW3 A0A8P0NGW3_CANLF Tectonin beta-propeller repeat-containing protein 1 TECPR1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome membrane [GO:0000421]; lysosomal membrane [GO:0005765] AGTKPPSL;DLSVGGWEITDEPVG;GLSPSVQTLSLSITPA;LEASEHMLP;LWEGQALVREGINRNNPKGSSWSI;QEGWQYASDFPASYHGYKTM;QLPDVSCYFLP;SENGIMHVSVGV;TAWVYTGGYGGGCFQ;WELCKDNRLEF 10 11.9 1.002 -1.798 0 10.474 0 0 7.29462 0 10.2383 6.18329 11.2222 0 7.39283 0 0 9.55207 0 A0A8P0NGX3 A0A8P0NGX3_CANLF Dmx like 2 DMXL2 Canis lupus familiaris (Dog) (Canis familiaris) DSALEEEEEDAV;GGDILEEEEEIDNK;GGSEWVLEQTIHLDDLVKVG;LILWRVDPIGPLS;LSSVTYNLAWDPQ;NIKHLVHLDWV;NLLSSAQDEDQPKLNILLCEAVVA;RMFEWTRPQQLVCFRQAG;SIIPQDHHEVKRR;SLPGLTRLEQMF;STHDVQELDVT;TIHHLKNL;VLASTHDVQELDV;VLDSRVSVDSNLFV;WDPQDNRLLTATDSIQ 15 6.5 0.96618 0.048494 0 0 0 0 0 0 10.845 0 9.42293 0 0 0 0 0 0 A0A8P0NH07 A0A8P0NH07_CANLF Anoctamin ANO8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTRLPAFLSFKFL;EDFIYENVESELRF;EEEEEDDEEEGEESG;ESPEPPAPSPSPSPSPQAV;GGGGGGSG;LEYQRREAFKRHERQAQHRYQQQQR;LKKVSFAE;LSGGCGAP;PFGGARADTGSNGAGGQARLD;TSSAGGTS 10 11.3 0.95471 0.05194 7.78005 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NH12 A0A8P0NH12_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase) SLC27A1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] ligase activity [GO:0016874]; nucleotide binding [GO:0000166] DTTGTFKIQKTRLQ;EFYGATECNCSIANMD;GYMYFRDRS;YFRDRSGDTFR 4 6.9 0.99174 -0.002526 0 0 0 0 0 11.1794 0 9.77665 0 0 11.9283 11.8456 0 0 8.31859 A0A8P0NH30 A0A8P0NH30_CANLF Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Hemin-sensitive initiation factor 2-alpha kinase) EIF2AK1 Canis lupus familiaris (Dog) (Canis familiaris) post-transcriptional regulation of gene expression [GO:0010608] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DESACPYVMASVATK;NSGNVNLTLQMKILEQEK;VPAPPAIEFPAD 3 7.8 0.99279 -0.14113 0 0 13.1419 0 0 0 0 0 0 0 0 0 12.7861 0 4.57331 A0A8P0NH36 A0A8P0NH36_CANLF Cytokine dependent hematopoietic cell linker CLNK Canis lupus familiaris (Dog) (Canis familiaris) CQSPARYSPQENL;VPMEHHHWHTQMGLGK 2 6.8 0.98711 -0.49844 0 0 0 0 7.47419 0 0 0 0 0 0 0 0 0 0 A0A8P0NH43 A0A8P0NH43_CANLF Homeobox protein MSX-1 (Msh homeobox 1-like protein) MSX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAGASLYGASGPFQ;GGGQAPSA 2 7.3 1.0018 -1.2615 0 0 0 0 0 0 0 0 0 11.4751 0 0 0 0 0 A0A8P0NH53 A0A8P0NH53_CANLF Histone deacetylase 6 HDAC6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] zinc ion binding [GO:0008270] DEQLNEFHCLWDDSFPEG;ENWVCLSCYQVY;GVLQENWVCLSCY;GVLQENWVCLSCYQV;LEEDILEEEK;RMMGHYNLWDNHHPEMPQ 6 5.4 1.0027 -0.72894 0 0 0 0 7.57266 0 5.88714 0 0 6.93204 0 0 8.61563 0 8.91683 A0A8P0NH58 A0A8P0NH58_CANLF Transmembrane 4 L six family member 5 TM4SF5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGSYLLNHTLW;GVLGAIYC 2 9.6 1.0036 -1.0689 0 0 4.0591 0 0 7.25125 0 0 0 0 0 0 0 0 0 A0A8P0NH59 A0A8P0NH59_CANLF Dihydropyrimidinase like 3 DPYSL3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; growth cone [GO:0030426] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" DLQLSGSAHCTFST;LSEAPKWMR;TKAALAGGTTMIIDHVVPEPEA;TSPPLSPDP 4 9.5 0.98649 -0.39161 9.45364 0 0 0 0 0 8.1282 0 0 0 9.7845 0 0 0 0 A0A8P0NH82 A0A8P0NH82_CANLF Coiled-coil domain containing 170 LOC480351 Canis lupus familiaris (Dog) (Canis familiaris) SPVASFDP 1 1.4 1.0039 -1.1044 0 0 8.71606 0 0 0 0 0 0 0 0 0 0 0 7.84461 A0A8P0NH88 A0A8P0NH88_CANLF Zinc finger MYND-type containing 15 ZMYND15 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872] EAEEEEEEEEN;EANPPGETEEAEQ;EGEEAEEEEEEEENREE;ESSEYGCV;LPHMALELQFVGDGLPLDS;TPAAPPAPARRRRGE 6 10.3 1.0017 -1.3192 0 0 0 0 6.60862 0 7.57818 0 6.75208 0 11.2841 0 0 0 13.4612 A0A8P0NH99 A0A8P0NH99_CANLF C2H2-type domain-containing protein LOC490972 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GVLVSPTP;KLQKHAALASKLALQKQ;SAPFHCALCQLQVNSETQLKQ 3 9.2 1.0026 -1.0105 0 0 0 0 0 0 6.78241 0 0 9.43488 5.35092 0 0 0 0 A0A8P0NHA8 A0A8P0NHA8_CANLF Cytohesin 3 CYTH3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] guanyl-nucleotide exchange factor activity [GO:0005085] CTCACGSAHP;LDAYLQTHQL;RKPNCFELYNP;THTFFNPDREGWLLK;YLQTHQLVHMPIFNLPRYCQ 5 10.8 1.0037 -1.1047 0 0 0 0 11.4556 0 0 0 0 0 0 0 0 0 0 A0A8P0NHB2 A0A8P0NHB2_CANLF Solute carrier family 35 member E1 SLC35E1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RDSRIHHL;SAHVSIWKVPVSYAHT;SIWKVPVSY;VGAGAGAG;VSIWKVPVSYAHTVKA 5 8.5 1.003 -2.3054 0 0 0 0 9.85278 0 0 0 0 0 0 6.99582 10.3738 6.57599 0 A0A8P0NHD5 A0A8P0NHD5_CANLF "Beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.244)" B4GALNT3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi cisterna membrane [GO:0032580] acetylgalactosaminyltransferase activity [GO:0008376] ALLLLLLRPVKL;ALLLLLLRPVKLL;ALLLLLLRPVKLLR;DTIRKHCV;EEEEEEEEDMS;EEEGEEEEEEEEEDMSEVFEY;EEGEEEEEEEEEDMSEVFEYVP;GSPRAALLLLLLRPVKLLRRRF;LLLLLLRPVKLLRRR;LLLLLLRPVKLLRRRF;LLLLLLRPVKLLRRRFR;LLLLLRPVKLLRR;LLLLRPVKLLRRRFRLLLAL;LLLRPVKLLRRRFRLLL;LLLRPVKLLRRRFRLLLA;LLLRPVKLLRRRFRLLLAL;LLRRRFRLLLALALV;QRPVRLSEY;RAALLLLLLRPVKLLRRR;SPRAALLLLLLRPVKLLRRRFRLLL 20 7.1 0.97446 0.047166 0 0 0 0 0 0 7.16239 0 0 0 0 0 0 0 0 A0A8P0NHD8 A0A8P0NHD8_CANLF G protein regulated inducer of neurite outgrowth 2 GPRIN2 Canis lupus familiaris (Dog) (Canis familiaris) KVESTRPQHL 1 2.4 0.98516 -0.23558 0 0 0 0 0 0 0 0 0 0 10.7259 0 0 0 0 A0A8P0NHE2 A0A8P0NHE2_CANLF Ferritin FTH1 LOC403631 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] ASAMTTASPSQVRQNYHQDSE;RIFLQDIKKPD 2 8.1 0.98298 -0.25185 0 0 0 0 0 0 0 0 0 0 0 0 7.51349 0 0 A0A8P0NHE5 A0A8P0NHE5_CANLF "Consortin, connexin sorting protein" CNST Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of Golgi to plasma membrane protein transport [GO:0042998] membrane [GO:0016020]; trans-Golgi network [GO:0005802] connexin binding [GO:0071253] EIDDDLDQVGG;ESPMCTDFAD;LEGCLKDTEDSLSCEENQEEDSD;QEDLPSDDSSL;VGRDRKVPGKRSTRTKKGMTKI 5 10.8 1.0026 -0.98082 0 2.74509 0 0 0 7.96786 0 0 0 0 0 12.9027 0 0 10.1424 A0A8P0NHF1 A0A8P0NHF1_CANLF NHR domain-containing protein NEURL4 Canis lupus familiaris (Dog) (Canis familiaris) DDTMHILVDGEDMGPA;GPGAGGGPGLPPSLPE;LGLTTLAPGE;LSREPLRDGRVFTVRI;QVRIDFLNRQWTSS;SVLDFPSSATGLKGGSWV;VEELDEKWAGSLR;VGIRRGADDTMHILVDGEDMGPAAT;WTSSLVLGVITCPP 9 8 1.0037 -0.83444 0 0 0 0 0 9.33434 11.3475 0 0 9.96939 3.63273 0 0 0 11.0119 A0A8P0NHF5 A0A8P0NHF5_CANLF UDP-glucose 6-dehydrogenase (EC 1.1.1.22) UGDH Canis lupus familiaris (Dog) (Canis familiaris) UDP-glucuronate biosynthetic process [GO:0006065] NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] EVVESCRGKNL;FFSFRESSSIY;SINSISALCEATGADVE 3 7.9 0.99254 -0.068699 0 0 5.53702 0 0 0 0 10.7947 0 0 0 0 0 0 0 A0A8P0NHG1 A0A8P0NHG1_CANLF RING-type domain-containing protein RNF216 Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740]; zinc ion binding [GO:0008270] KIEKRMFFLENKRRHCRSYDRRALL;KLENLWGQEATEV;LRCALGHLPVE;PGAPCQECSRCSLW;QECSRCSLW;TSELEKVL;VNYDFAPVHMPLEHNL 7 10.6 0.99778 -0.10317 0 0 0 0 0 11.7124 0 0 0 0 0 0 0 8.26172 11.8458 A0A8P0NHH4 A0A8P0NHH4_CANLF protein-arginine deiminase (EC 3.5.3.15) PADI2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668] EASSDKVTVNYYDEEGSMPIDQ;VLGTYLWTDVY 2 5.4 0.98963 -0.20342 0 7.88062 0 0 0 0 0 0 0 0 0 0 0 8.35812 0 A0A8P0NHH6 A0A8P0NHH6_CANLF Pleckstrin homology and RUN domain containing M2 PLEKHM2 Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764] DLPHKPIQE;EVIRVTKKKKTGKKK;EVIRVTKKKKTGKKKKARL;LEVIRVTKKKKTGKKKKARLDEEA;LFKMIRMSTGHMEGNLQLL;LVSGLEFIRFDLDLDAPYLD;SPCIPCCLVITDD;VLCHCSPPEGTIT 8 9.5 0.9912 -0.26958 0 6.25629 11.6679 0 0 0 0 4.8541 13.1108 5.4662 10.6252 0 0 7.58278 0 A0A8P0NHI1 A0A8P0NHI1_CANLF Adiponectin receptor 2 ADIPOR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] GVAGNGQG 1 1.6 1.0043 -1.1044 8.32085 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NHJ3 A0A8P0NHJ3_CANLF G-protein coupled receptors family 1 profile domain-containing protein NPY4R Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] neuropeptide Y receptor activity [GO:0004983] IVYTTSLLLFQYC;NSVLENVF;SVDLMVFIVT 3 8.3 1.0017 -1.2869 0 0 0 0 8.8089 0 0 0 6.64559 0 0 0 0 0 0 A0A8P0NHK6 A0A8P0NHK6_CANLF Fatty acid desaturase 1 FADS1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] oxidoreductase activity [GO:0016491] LLPLYFQWYIFYFVIQRKKW;LVQSLCAK;LYFQWYIF;NFQIEHHLFP;WLQHDFGH 5 12.8 1.0021 -1.8285 0 8.19854 0 10.6426 0 0 0 0 7.4489 0 0 0 0 7.8339 0 A0A8P0NHK8 A0A8P0NHK8_CANLF WD repeat domain phosphoinositide-interacting protein 2 WIPI2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site membrane [GO:0034045] lipid binding [GO:0008289] LEQIYECTDTE;LVAIVSLKAPRKLK;VDKLEQIYECTDTE;VGASDGYLYMYNLDPQE;VIRVFSIPE;YFGKVLMASTSYLPSQVTEMF 6 17.6 0.9866 -0.39586 0 0 10.3756 8.61703 0 0 0 0 11.107 0 0 0 0 0 5.52963 A0A8P0NHM7 A0A8P0NHM7_CANLF Retinol binding protein 3 RBP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type peptidase activity [GO:0008236] AAEAFAHTMQDL;DLQEMSGDH;DSVSELWTHS;EAWDLAGV;IGQSDFFLTVP;ITIPTARSVGAADGGSWEGVGVV;LVFHSPGEMV;RYPTQRGVYL;SMPTQMALSASTGEA;SRVTSEGALAEMLAADL;VISYEPSTLEAPRQ;VLSPYVARQVWEP 12 12.2 1.0032 -2.4558 10.332 10.9324 7.71754 0 11.198 13.0778 14.0371 14.2004 12.3081 0 8.9624 11.7074 0 12.0691 0 A0A8P0NHP0 A0A8P0NHP0_CANLF G protein nucleolar 3 like GNL3L Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] GTP binding [GO:0005525] VPGPNSEVGTILRNC;VTPVETILQRCN 2 5 0.98485 -0.24143 0 0 0 0 0 0 0 0 0 0 11.2466 0 0 0 0 A0A8P0NHQ3 A0A8P0NHQ3_CANLF Zinc finger and BTB domain containing 4 ZBTB4 Canis lupus familiaris (Dog) (Canis familiaris) AEYRTKHEVWHTG;ATAAGPATATEEAKGRNPRAG;DDDDDDDDEDDEAS;DDDDEEDDDDDDDDD;DEEDDDDDDDDDEDDEASRAG;EDDDDDDD;EDDDDEEDDDDDDDDDEDD;EEDDDDDDDDDE;EEDDDDDDDDDEDDEA;EEDDDDDDDDDEDDEAS;EEDDDDEEDDDDDDDDDE;EEVESEEDDDDEEDDDDDDD;ESEEDDDDEEDDDDDDDDDED;EVESEEDDDDEEDDDDDDDDD;EVESEEDDDDEEDDDDDDDDDED;GAGGSGVGA;GEGERAGLE;PGELSGEEVESEEDDDDEEDD;QPAATPTSPATAGSPATAAGPATA;SEDDSFGPGP;SEEDDDDEEDDDD;SEEDDDDEEDDDDDD;SEEDDDDEEDDDDDDD;SEEDDDDEEDDDDDDDDDED;VESEEDDDDEE;VESEEDDDDEEDDD;VESEEDDDDEEDDDDD;VESEEDDDDEEDDDDDD;VESEEDDDDEEDDDDDDD;VESEEDDDDEEDDDDDDDDD;VESEEDDDDEEDDDDDDDDDE 31 11.2 1.002 -1.2677 6.79168 10.4282 9.32118 6.00984 8.14512 7.2076 10.6528 11.0961 8.70926 7.02636 6.43683 10.9293 8.88163 8.17273 7.87055 A0A8P0NHR0 A0A8P0NHR0_CANLF V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) ATP6V1D Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] clathrin-coated vesicle membrane [GO:0030665] "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DEKGRKRRRVL;YRLKKIQEKKKILK 2 6.5 0.98542 -0.24103 0 0 0 4.30539 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NHR6 A0A8P0NHR6_CANLF GIPC PDZ domain containing family member 1 GIPC1 Canis lupus familiaris (Dog) (Canis familiaris) GVTPCILGVWS;KEGSVIDHI;PLVENEEAEPGR 3 8.1 1.0024 -1.3239 0 10.5421 0 0 0 9.23065 0 0 0 0 0 0 9.84887 0 0 A0A8P0NHR9 A0A8P0NHR9_CANLF Vacuolar protein sorting 13 homolog D VPS13D Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] ERNLDKEISHTVP;ILEQHTREVLV;INDILKHFQEELLSQAAR;KESVPSASPTGTPK;KFLFAGFPGTFSL;KQKEVQDKDCPLTPPP;LDIEAGAP;LGSVDFLGNPMGLLNDVSEGV;LKIQDVHLRFEDGITNPS;LSQLQYRQMMAF;LVAGIHGL;LVSKDHGKVYVQ;NLDKEISHTVPDISIHG;PVTEQEVQKLK;QAHLMSTKMYE;QVERNLDKEISHTVPD;RESELTFSLSPDDLGT;RQSRFRRWKPRVAVSENCREWWYF;SLENFPLCKE;TPIRYYFENLKIS;TPLATPPNTP;VGTFFRYAAPDK;VSPKTQRV;VVFHWPRNDYDQLL 24 6.9 0.99832 -3.2908 0 10.9066 10.4689 8.144 11.5231 7.19535 11.1241 0 0 7.18497 9.81518 8.31438 7.79597 6.22188 10.7634 A0A8P0NHS0 A0A8P0NHS0_CANLF Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Lysosomal cytochrome b) CYB561A3 Canis lupus familiaris (Dog) (Canis familiaris) late endosome membrane [GO:0031902] oxidoreductase activity [GO:0016491] FANSLGMLVVVFGLLVL 1 7.1 0.97825 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 7.22468 0 A0A8P0NHT6 A0A8P0NHT6_CANLF Arylacetamide deacetylase like 4 AADACL4 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] DKKFFFFP;NEAAYLENKH;TDSVLLLIGYRKL 3 7.7 1.0038 -1.062 0 0 0 0 0 0 0 0 0 0 0 8.80449 0 4.83345 0 A0A8P0NHV3 A0A8P0NHV3_CANLF "Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (Nucleoside diphosphate-linked moiety X motif 1)" NUDT1 Canis lupus familiaris (Dog) (Canis familiaris) DNA protection [GO:0042262] nucleus [GO:0005634] "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; metal ion binding [GO:0046872]" AGPLTCPLRSPQP;EESGLTVDTLHKVGQIMFE;RPQWFQLDQ;TLPQLGSSHIG 4 10.4 0.979 0.035491 0 0 0 0 0 0 0 0 9.66715 0 0 0 0 0 0 A0A8P0NHV7 A0A8P0NHV7_CANLF Cornichon family AMPA receptor auxiliary protein 3 CNIH3 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] membrane [GO:0016020] FHCPADSSELA;LFCIMFLCAQEWLTL;PDRTPPRSECGPRGR;TVHWLNPV 4 11.2 1.0018 -0.96112 7.49689 0 0 0 0 8.57867 0 0 0 9.48961 0 0 0 0 10.734 A0A8P0NHY6 A0A8P0NHY6_CANLF Acyltransferase (EC 2.3.1.-) AWAT2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] KPLPLPKIENP;WLAFDWKTPERGG 2 7.2 0.98975 -0.21753 0 0 0 0 0 0 0 0 0 0 9.35506 0 4.52594 0 0 A0A8P0NHY9 A0A8P0NHY9_CANLF Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) MRI1 Canis lupus familiaris (Dog) (Canis familiaris) L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284] cytoplasm [GO:0005737]; nucleus [GO:0005634] S-methyl-5-thioribose-1-phosphate isomerase activity [GO:0046523] GVRIAAPG;VLTHCNTGALATAGYG 2 6.7 1.0019 -1.3215 0 10.9806 0 0 0 0 11.1631 11.1367 11.2877 0 0 0 0 0 0 A0A8P0NI30 A0A8P0NI30_CANLF Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD3 Canis lupus familiaris (Dog) (Canis familiaris) superoxide metabolic process [GO:0006801] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] WQQLTQRAAEPGAPGSAL 1 6.7 0.98053 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4094 A0A8P0NI43 A0A8P0NI43_CANLF FMR1 autosomal homolog 2 FXR2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytoplasmic ribonucleoprotein granule [GO:0036464]; postsynapse [GO:0098794] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; mRNA binding [GO:0003729]" EACRQARSYLEFSEDSVQVP;NCIFLNITNSE;TEGDEVEVYSRANE;TEGDEVEVYSRANEQ;VGYGLYYFIYSTW;VIQEIVDKSGVVR 6 8.7 1.0015 -0.70086 8.08879 7.78398 0 7.89008 0 7.66966 0 0 11.3359 0 9.01929 9.04851 0 8.68004 0 A0A8P0NI45 A0A8P0NI45_CANLF Oxysterol-binding protein OSBPL7 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] cytoplasm [GO:0005737] lipid binding [GO:0008289] ESCTSEITTSLSE;RLDMPRGSLPGTTH 2 3.2 0.99255 -0.18082 0 0 0 10.8671 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NI52 A0A8P0NI52_CANLF Syntaxin 4 STX4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] DDSSDDEDK;QEHVKIALENQK 2 7.1 1.0019 -0.75377 0 0 0 0 0 0 0 0 3.94476 0 0 7.06145 0 0 0 A0A8P0NI58 A0A8P0NI58_CANLF "SET domain containing 1A, histone lysine methyltransferase" SETD1A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] Set1C/COMPASS complex [GO:0048188] histone H3K4 methyltransferase activity [GO:0042800]; RNA binding [GO:0003723] ASEAPPPEPPEPGGGGGGGP;EEPEPERVAGSP;KRRKTVSFSALEEVPAP;LDEFYIGQ;LFAMEPIAAD;LNQLKFRKKKL;PGGGGGGG;QESSSEKEEEEEEEDEED;TVPSASPPPRDVPAPPP 9 6.6 0.99226 -0.28836 0 0 0 0 4.68577 0 0 0 10.0088 0 0 0 0 0 11.4912 A0A8P0NI61 A0A8P0NI61_CANLF [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) KDM6B Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] histone demethylase activity [GO:0032452]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] EPAQPGLWEQLGQLYE;GAEGRPRPPPPPLPHREGF 2 2.2 0.99097 -0.14638 0 0 0 0 0 0 0 11.7378 0 0 0 0 0 0 0 A0A8P0NI72 A0A8P0NI72_CANLF G patch domain-containing protein 4 GPATCH4 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] EFTDHWWDELFN;KPLKKKKKKRKQ;KSRKIKKKSL;SKPLKKKKKKRK 4 8.3 0.9877 -0.46014 0 0 7.01357 0 0 0 0 7.40293 6.24352 9.31404 0 0 0 0 0 A0A8P0NI74 A0A8P0NI74_CANLF CIDE-N domain-containing protein DFFA Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] DDYFLCLPSNTKFVALA;VGAAEAET 2 9.5 0.98996 -0.21969 0 0 0 8.97011 0 0 0 0 0 11.7655 0 0 11.8543 0 0 A0A8P0NI86 A0A8P0NI86_CANLF Nucleus accumbens associated 1 NACC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] GVAVAAAAGAGAGQPAGGAAA;PAAVQPQSFQRILSF 2 6.8 0.99437 -0.12398 0 0 10.6844 0 0 0 0 8.20408 0 0 0 0 0 0 0 A0A8P0NIE0 A0A8P0NIE0_CANLF Nuclear distribution protein nudE-like 1 NDEL1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; spindle [GO:0005819] microtubule binding [GO:0008017] YGDFSCFLLTSAWFSAG 1 4 0.9891 -0.26276 0 0 0 0 0 0 10.3932 0 0 0 0 0 0 0 0 A0A8P0NIE3 A0A8P0NIE3_CANLF Lactamase beta LACTB Canis lupus familiaris (Dog) (Canis familiaris) GVKLAGGL;MIWTPVPNTE;QKIFHDLDMLTTVQE;TVGDLLKFGNAMLYGYQ;VESDQEKEFREKGGKSN 5 12.1 1.0031 -1.5332 0 0 5.3837 0 7.52419 0 0 10.589 9.8833 0 0 0 0 0 0 A0A8P0NIF7 A0A8P0NIF7_CANLF Protein-serine/threonine kinase (EC 2.7.11.-) PDK2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DLQLFSMEGFG;PVYNKSAWRHYQTIQ 2 6.4 0.9864 -0.418 0 0 0 0 9.50589 0 0 0 0 0 10.2451 0 0 0 0 A0A8P0NII3 A0A8P0NII3_CANLF Potassium two pore domain channel subfamily K member 10 KCNK10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] AAPPVCQPKGAANG;WLRVLSKKTKEE 2 4.9 0.99036 -0.53628 0 0 0 0 0 0 0 0 11.7217 0 0 0 0 0 0 A0A8P0NIJ5 A0A8P0NIJ5_CANLF Sterile alpha motif domain containing 15 SAMD15 Canis lupus familiaris (Dog) (Canis familiaris) IESCTEVSKED;PESNEELYYT;PKESMQPQFDYLKWS;PLAMAQDAEADATAQGGP 4 8.3 1.0026 -0.76876 0 9.24679 0 0 0 0 0 0 0 9.06803 0 0 0 0 0 A0A8P0NIL2 A0A8P0NIL2_CANLF Kelch like family member 4 KLHL4 Canis lupus familiaris (Dog) (Canis familiaris) AMLLSYIRLPLLPPQLLVD;VLLLKVLKL;VLLLKVLKLVHFRF 3 5.9 1.0014 -0.69404 3.22796 0 0 0 0 0 0 0 4.68616 6.13693 0 0 0 0 0 A0A8P0NIL8 A0A8P0NIL8_CANLF Essential meiotic structure-specific endonuclease 1 EME1 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281] Holliday junction resolvase complex [GO:0048476]; nucleus [GO:0005634] DNA binding [GO:0003677]; nuclease activity [GO:0004518] EQAKEKQQRQPEAN;PIQNSSLTIT;SSTKRRQPQ;VDTSDSEASCPPS 4 7.9 1.0016 -0.74793 0 0 0 0 0 0 0 0 12.9353 0 0 0 0 0 0 A0A8P0NIM1 A0A8P0NIM1_CANLF Mucin-1 MUC1 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; nucleus [GO:0005634] SLGKHSSSSLTSSPVSGSI;SSAPFKSGVPGWG 2 9.5 0.10185 0.85664 0 0 8.90029 0 0 0 0 0 0 10.2743 0 0 0 0 0 A0A8P0NIM8 A0A8P0NIM8_CANLF Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein NOXRED1 Canis lupus familiaris (Dog) (Canis familiaris) AAVPIARLKLLL;GLMIKACAHATF;RLKLLLNHTNILR 3 9.3 0.9872 -0.23029 0 0 0 0 0 0 0 0 0 3.30604 0 0 0 0 9.16128 A0A8P0NIP6 A0A8P0NIP6_CANLF Coiled-coil domain containing 88C CCDC88C Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton-dependent intracellular transport [GO:0030705] cytoplasm [GO:0005737] DLLRASGPEA;KKKNHWIGAKALVKLIKPKKEG;MAQIERENQELEREKEELRENVEL;MRFTSAKMAQIEREN;QEHNTTLQTQTAK;STEYEALIRQHS 6 4.4 0.99017 -0.29871 0 0 9.33599 5.59141 0 0 0 11.0338 0 0 0 6.6476 8.96 9.30734 7.34003 A0A8P0NIQ1 A0A8P0NIQ1_CANLF Transmembrane p24 trafficking protein family member 8 TMED8 Canis lupus familiaris (Dog) (Canis familiaris) DSSEDEDEDEEEEEE;EDEDEEEE;EDEDEEEEEEIEDP;PCIWTFAKMKEFKSKLGKEK 4 12.5 0.85959 0.16285 0 0 0 0 0 2.98165 6.30444 0 6.29615 0 0 0 0 0 0 A0A8P0NIQ7 A0A8P0NIQ7_CANLF "Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial)" ABCB7 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CELFIYGLYYVE;YDEATSSL;YFNNENYEAQRYDRFL 3 4.9 0.98641 -0.41133 0 0 0 0 0 0 7.97436 0 0 4.98025 0 0 0 0 0 A0A8P0NIQ8 A0A8P0NIQ8_CANLF Calcium voltage-gated channel subunit alpha1 H CACNA1H Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] AEGDANRSDTDEDKTSTHLEED;CINWNQYYNVCR;DRRDPMQPAPV;DTRNISTKAECR;EAEEARRREEKRQRRLERKRRKAQR;EPYKPAWCRSR;GAKILGILRVLRLLRTLRPL;GILRVLRLLRTLRPLRVI;GVAPEPRASFS;ILGILRVLRLLRTLRPLRVISRAP;ILRVLRLLRTLRPLRVI;KILGILRVLRLLRTLR;KILGILRVLRLLRTLRPLR;LGILRVLRLLRT;LSVLRTFRLLRVLKLVRFM;PNFAFEPPDKG;RGLHLRVL;RLLRVLKLVRFM;RVLRLLRTLRPLRVISRAPGLKL;SNDSTLASFSE;SVHSVYHAD;VLRLLRTLRPLRVISRAPGLK 22 8.6 1.0026 -1.3476 5.64184 9.20543 10.5777 9.0773 10.8888 0 11.3999 8.94591 8.31288 0 8.07986 9.1139 7.96688 10.3343 8.50311 A0A8P0NIR8 A0A8P0NIR8_CANLF WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) WDR83 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LSGSIDSSIRCWDC 1 4.4 0.9334 0.060842 0 0 0 0 0 0 0 0 8.45984 0 0 0 0 0 0 A0A8P0NIT1 A0A8P0NIT1_CANLF Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) DNM2 QTRT1 Canis lupus familiaris (Dog) (Canis familiaris) tRNA-guanine transglycosylation [GO:0101030] mitochondrial outer membrane [GO:0005741] metal ion binding [GO:0046872]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] TEMTKRDVPGF;TPVFMPVGTQATM 2 5.9 0.98251 -0.25039 0 0 0 0 0 0 0 0 11.7217 0 0 0 0 0 0 A0A8P0NIU5 A0A8P0NIU5_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2B1 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] EIAFFSRWWQQQT;GRKTLPLLLLLLLPP;LLLLLLLP;PSPSRTCRRPRWQ;PYGSGDSAPLNEA;RFDPDTGFLVELENLE;VGEGSGNL;VISRFDTVLETKGLFYT 8 9.7 0.95651 0.053874 0 0 0 0 0 4.53543 0 0 0 0 0 0 0 0 0 A0A8P0NIW6 A0A8P0NIW6_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF43 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transferase activity [GO:0016740] AEITPAEGKLMQSH;SSGPCYSSSQPVWLCL 2 4 0.98968 -0.21579 9.35407 0 0 0 9.84728 9.71593 11.4897 0 0 0 11.5602 0 0 0 0 A0A8P0NIW8 A0A8P0NIW8_CANLF Interleukin-4 receptor subunit alpha IL4R Canis lupus familiaris (Dog) (Canis familiaris) production of molecular mediator involved in inflammatory response [GO:0002532] membrane [GO:0016020] cytokine receptor activity [GO:0004896] DAGGPGFG;LSEAPVDNEEE;PSPCCGCCCG;PVDNEEEEEVEEDKRS;SPASLVPSGVSKEGKSSPF;VPSPCCGCCCGDRS 6 7.4 0.94859 0.056162 9.66642 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NIZ0 A0A8P0NIZ0_CANLF PML nuclear body scaffold PML Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] zinc ion binding [GO:0008270] DALHRLRQEEPHDL;DRPLVFFDLKIDSE;LVSCITRGTAVPR;SFTELLAAHRRDPQQ 4 6.4 0.9915 -0.27743 0 0 6.79338 10.1361 0 0 8.99447 0 0 0 9.6193 0 0 0 0 A0A8P0NIZ7 A0A8P0NIZ7_CANLF Angiopoietin like 6 ANGPTL6 Canis lupus familiaris (Dog) (Canis familiaris) AMSAPPLRTLQLLLLLGA;GGHYRSRYQDGV;GPSPGLEPSL;GVHSGYEFRTLGTGRRTLLP;LEPESDYYRLRLGQY 5 12.9 0.97904 0.048313 0 0 0 0 4.59979 0 0 0 0 0 0 0 0 0 0 A0A8P0NJ00 A0A8P0NJ00_CANLF Integrator complex subunit 3 INTS3 Canis lupus familiaris (Dog) (Canis familiaris) DEGCYDNAEAAFSDDEE;ELEERLERCMSI;GVFSSLNHIVE;LLQNVARIPEFELLWKDI;LSSDILPRWAIIGWLLTTC;SVEMDNHMSDKDEGCYDN;VDFCMSLL 7 9.2 1.0025 -1.149 0 0 0 0 0 0 0 0 0 0 0 6.83719 10.1524 11.5209 8.82585 A0A8P0NJ04 A0A8P0NJ04_CANLF KIAA1328 KIAA1328 Canis lupus familiaris (Dog) (Canis familiaris) ASLKDLCLEDKRR;DDTDMIWTCQKKDT;QCCGHRLSENADPVH 3 6.8 0.98941 -0.30996 0 0 0 0 9.95651 10.5499 0 0 0 0 0 0 0 0 0 A0A8P0NJ08 A0A8P0NJ08_CANLF "SPT4 homolog, DSIF elongation factor subunit" SUPT4H1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; transcription elongation-coupled chromatin remodeling [GO:0140673] nucleus [GO:0005634] zinc ion binding [GO:0008270] FEYDGCDNC;SHAGRGSP 2 5.2 1.003 -1.9086 0 9.40135 0 0 5.3965 0 0 0 0 0 8.77063 0 0 0 0 A0A8P0NJ10 A0A8P0NJ10_CANLF Ariadne RBR E3 ubiquitin protein ligase 1 ARIH1 BBS4 Canis lupus familiaris (Dog) (Canis familiaris) ciliary membrane [GO:0060170] AEGLWLLARPTL;AIEIYKKA;PRLKKAQEFPILEKQ 3 6.4 1.0024 -1.3681 0 0 0 0 7.17263 0 0 0 0 0 0 0 4.08142 0 0 A0A8P0NJ12 A0A8P0NJ12_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1D" PPM1D Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722] NSQETCLMTPSPCST 1 2.5 0.98734 -0.2305 0 0 0 0 0 13.4414 0 0 0 0 0 0 0 0 0 A0A8P0NJ29 A0A8P0NJ29_CANLF ER membrane protein complex subunit 2 LOC481017 Canis lupus familiaris (Dog) (Canis familiaris) EMC complex [GO:0072546] LYDRILQEDPTNTAAR;NMRALFGLYMSAS 2 9.9 0.8057 0.21933 0 0 0 0 0 0 0 0 11.6442 0 0 0 0 8.20168 0 A0A8P0NJ31 A0A8P0NJ31_CANLF DNA repair protein RAD51 homolog 3 RAD51C Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677] TAEELLEVKPCELSKE 1 4.3 0.99081 -0.0033125 0 0 0 0 9.06366 0 0 0 0 0 0 0 0 0 0 A0A8P0NJ57 A0A8P0NJ57_CANLF "RPA1 related single stranded DNA binding protein, X-linked" RADX Canis lupus familiaris (Dog) (Canis familiaris) single-stranded DNA binding [GO:0003697] EDLQYREQKRIAIQGIITVIKYIP;EDLRTSQI;KVKNFIHWIKT;RILHKSKLRY;VTPSEVVPVAVL 5 7.6 1.0033 -1.7018 8.72427 14.0702 14.1595 0 0 0 0 10.0377 9.7778 0 11.8466 0 0 0 13.8076 A0A8P0NJ65 A0A8P0NJ65_CANLF Serpin family A member 5 SERPINA5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EAMVMVNYIFF;FKSAPMRPHKIMFNRPFMML;SIEGSYQLDKVL;STRKQDFHVTSEMVVQ;TNILFLGKVTHP;VTSEMVVQVPMMKQEDHYYY 6 16.3 0.99374 -0.026831 0 9.5755 10.1874 0 6.47088 0 11.4447 0 0 0 8.17378 0 8.73836 0 9.60366 A0A8P0NJ77 A0A8P0NJ77_CANLF Angiomotin AMOT Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HHQQLVAHAARQEPQGQE;HQSDHYRLPQP;LESLRIQQRQ;PAATASAPSPAAAT;QLAEKEYEGSEDTRKTISQLFAKN;VISHSPNTSYDTAL;YFRGQQHASVGA 7 9.5 1.0023 -1.2455 8.28605 0 0 0 0 0 0 0 0 11.0562 0 0 0 10.4972 7.71143 A0A8P0NJ82 A0A8P0NJ82_CANLF Lipoxygenase homology PLAT domains 1 LOXHD1 Canis lupus familiaris (Dog) (Canis familiaris) AFEKANVD;ASKDIFQLEAQDVGE;DEEDEEDEEEESSSEESSSEE;DLLASFDPMDMPRGNKYEVRVYT;DVATVTGPMAAYVQEGP;EDEEEESSSEESSSEEEEEET;EEARKKKEKE;EEESSSEESSSEEEEEETE;GVFDRGRMDIFHIEL;KAKLQRKKKK;KAKLQRKKKKKKKK;KAKLQRKKKKKKKKG;KKERLKAKLQRKKKKKK;KKKKKKKGS;KKKKKKKK;KKKKKKKKGS;LLKKERLKAKLQRKKKKKK;MPRGNKYEVRVYTG;MTVWTGDVVGGGT;NEIVREMTAEG;NNEITYYFPCQ;QLLKKERLKAKLQRKKKKK;QRKKKKKKKKG;RKKKKKKKK;SSSEESSSEEEEEETEE;TDADVFINIFGEYG;VIEEYKFEAHRW;VLPSEDEEGGGGG;VPAGRPGP;VVGGGTDSNIFMTLY 30 10.5 0.99697 -6.1655 6.99842 7.68979 8.41975 3.62352 5.09293 0 12.6189 12.3739 4.33256 0 12.6581 0 9.77169 7.76042 6.22143 A0A8P0NJ85 A0A8P0NJ85_CANLF Cytochrome P450 1A (EC 1.14.14.1) CYP1A1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; lyase activity [GO:0016829] MMSMFRLSI;YLVTNPNV 2 3.5 1.0029 -0.75589 0 0 0 0 0 0 10.0003 0 0 0 0 0 0 0 0 A0A8P0NJ96 A0A8P0NJ96_CANLF Synaptotagmin 4 SYT4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IKMTILPEKKHKVKTRVLRKTLDPA;LDSERGSRNEVIG 2 8.9 0.9875 -0.36289 0 0 0 5.42921 0 0 0 10.4557 0 0 0 0 0 0 0 A0A8P0NJ98 A0A8P0NJ98_CANLF medium-chain acyl-CoA ligase (EC 6.2.1.2) ACSM3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] acid-thiol ligase activity [GO:0016878]; CoA-ligase activity [GO:0016405]; nucleotide binding [GO:0000166] PKIPEWWLAN;RWSFEELGSL 2 3.8 0.99234 -0.55121 0 9.0631 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NJC1 A0A8P0NJC1_CANLF Cadherin-2 (Neural cadherin) CDH2 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] adherens junction [GO:0005912]; cell surface [GO:0009986]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509] AQDPDRYMQQN;GAIIAILLCIIILLILVLMFVV;ILLILVLMFVVWMKRRD;NAAYRISGGD;YDEEGGGEEDQDYD 5 7.4 0.99156 -0.004707 0 5.13266 0 8.66139 0 0 0 0 0 0 4.75157 0 0 0 0 A0A8P0NJC2 A0A8P0NJC2_CANLF Zinc finger protein 287 ZNF287 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SEEVVTLV;TQHHRTHTGEK 2 2.5 1.0043 -1.1044 0 0 0 0 0 0 0 0 0 0 0 7.27529 0 0 0 A0A8P0NJC5 A0A8P0NJC5_CANLF Coiled-coil domain containing 69 CCDC69 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RKRRRKPDQPPRPE 1 4.8 0.93805 0.060769 0 1.73131 0 0 0 0 3.33271 0 0 0 0 0 0 0 0 A0A8P0NJC7 A0A8P0NJC7_CANLF Family with sequence similarity 83 member G FAM83G Canis lupus familiaris (Dog) (Canis familiaris) EDEDDDDY;EDEDDDDYVT;FYSEEQRLALEAL;LDGEEDEDDDDY;LDGEEDEDDDDYVTLSDQDS;SDEYFEVRGR;VGPGTRDPVQ 7 6.9 1.0031 -1.5643 0 0 6.46299 11.7519 0 0 13.0115 0 5.6686 0 0 0 0 7.5643 7.54009 A0A8P0NJD6 A0A8P0NJD6_CANLF Transmembrane protein 266 TMEM266 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated channel activity [GO:0022832] DLAAEREAALRAP;DLLSSPLEGPCP;GVPEPAACVVTTAAID;LSSPLEGPCP;LVACVILVVILLTLELLI;VILVVILLTLELLIDIKLLQ 6 12.1 1.0021 -0.99244 0 0 0 8.64843 10.642 0 8.29099 0 0 0 0 6.44513 0 0 0 A0A8P0NJD9 A0A8P0NJD9_CANLF Carbohydrate sulfotransferase (EC 2.8.2.-) CHST9 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] FYYLDYLMFNYT;IKLIERHQGT 2 5.5 0.99167 -0.53994 0 9.57588 0 0 0 0 0 0 9.44388 0 0 0 0 0 0 A0A8P0NJF4 A0A8P0NJF4_CANLF Sorting nexin SNX33 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281] cytoplasmic vesicle membrane [GO:0030659] phosphatidylinositol binding [GO:0035091] EDDDDDWDDW;EDDDDDWDDWD;FEEDDDDDWDDWDDGCTVVE;FLSHQGSFEEDDDD;GGFRKEFQKLGNAFQAISHAF;SFEEDDDDDWDDWDDGCTV;SPPRSAGGSG 7 10.1 1.0011 -0.74624 5.59962 0 0 10.5661 0 8.75138 0 0 0 0 0 0 9.9747 5.81106 0 A0A8P0NJF5 A0A8P0NJF5_CANLF CD74 molecule CD74 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955]; intracellular protein transport [GO:0006886]; protein trimerization [GO:0070206] extracellular region [GO:0005576]; membrane [GO:0016020] macrophage migration inhibitory factor binding [GO:0035718]; MHC class II protein binding [GO:0042289] KSTEVPLKEPLD 1 5.8 0.95197 0.05044 0 0 0 5.27858 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NJG1 A0A8P0NJG1_CANLF GREB1 like retinoic acid receptor coactivator GREB1L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADAANGNS;AEGISETLRTLS;KNALLGFSGNCIGCG;LDLDNETFQIYQPQL;LSVENMILLTIQ;LTVNEMEDDEDDEEM;QLDSMEDMSCQE;SPLLRCDETFEKMVNTLL;VILIGYGTLPYF;VLSKGPLICWKE 10 6.7 1.0027 -0.75442 10.2063 7.42509 0 0 9.17163 0 0 0 12.5988 0 7.65019 9.18644 11.3167 6.87836 5.74854 A0A8P0NJH2 A0A8P0NJH2_CANLF Rho GTPase activating protein 28 ARHGAP28 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AEVKPVDEGELEAEWLQ;DRKKDPGVKVPLVLQK;FIVQKTRFGLTE;LLKKQLPSVKKLLRRKTIE;LMVMALPDANRDT;LNSTTLSGGSQDEEGS;LRRKTIEREVI;NEATMLLKKQLPSVKKLLR;NRMSIWNISTIM 9 15.6 1.0035 -0.83027 0 0 9.84445 8.46728 0 5.36047 5.50456 0 0 6.28825 11.0091 0 3.15721 0 0 A0A8P0NJH9 A0A8P0NJH9_CANLF Cache domain containing 1 CACHD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGITSKDS;GRFYTNLP;HRMEQNECECPCECPL;LDQCYKTFL;MEQNECECPCE;NCHRMEQNECECPCECPLE;NETCDSLAFCACSMVDRLCLNCHRM;NQDGGNKIRCFIMEDRGYLVAHPTL;PSLTRPYLL;RLAKKIREKFN;RMEQNECECPCEC;RSGTESDHGYST;VKKNLCNSFSDRT;YSTMSPQEDSE 14 11.8 1.003 -2.5004 7.71624 7.07927 8.32782 12.7018 0 0 0 9.11847 9.75288 0 6.0646 7.43588 0 4.20813 0 A0A8P0NJQ1 A0A8P0NJQ1_CANLF 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) PSMD11 Canis lupus familiaris (Dog) (Canis familiaris) proteasome complex [GO:0000502] AQASKNRSLADFEKALTDYRA;TANAIYCPP 2 7.8 0.99419 -0.12234 0 0 0 0 0 0 0 9.90262 0 0 0 0 0 0 0 A0A8P0NJT2 A0A8P0NJT2_CANLF Z-DNA binding protein 1 ZBP1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of type I interferon-mediated signaling pathway [GO:0060340] DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; RNA binding [GO:0003723] ARPEDAGEPGKD;DMRKQHKLD;EAGGRVDRTADED;SNRMTVSSGTDGPGGV 4 11.4 0.9881 -0.22468 0 0 0 6.87676 0 0 0 0 11.1299 0 0 8.29957 0 0 0 A0A8P0NJV3 A0A8P0NJV3_CANLF Tyrosine-protein kinase (EC 2.7.10.2) JAK1 Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556] cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; membrane [GO:0016020] ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] AKMRSSKK;HYAMMKKMQ;LFALYDEN;LFAQGQYDLV;LIMEFLPSGS;LPCPPHCPEEVFVGHFTVINSIC;MMKKMQLPE;MMKKMQLPELPKDISY 8 6.7 1.0018 -2.6366 9.44636 0 0 0 0 7.5766 0 0 8.59062 0 0 8.45072 9.76936 0 0 A0A8P0NJY4 A0A8P0NJY4_CANLF CXXC-type zinc finger protein 1 CXXC1 Canis lupus familiaris (Dog) (Canis familiaris) Set1C/COMPASS complex [GO:0048188] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] ALRKRAVKVKHVKRRE;CDNCNEWF;CDNCNEWFHGDCI;EDEGAVASSAVKEPPEAT;ESNEGDSDDTDL 5 9 1.003 -1.3782 0 0 0 5.97916 0 3.49595 10.3849 0 10.0756 0 0 0 7.62388 0 0 A0A8P0NJZ6 A0A8P0NJZ6_CANLF Cytochrome P450 family 2 subfamily J member 2 CYP2J2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" KLFNDWEKLKLFIAHMTENHRRDWN;LPLIKEVLV 2 7.4 1.0023 -0.65176 0 0 0 0 0 0 8.05251 0 0 0 0 0 0 0 0 A0A8P0NJZ9 A0A8P0NJZ9_CANLF Flotillin DHRS13 FLOT2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] endosome [GO:0005768]; membrane [GO:0016020] SGGCCGSD;VEQIYQDRDQ;VGGRPPGARGAGPQ 3 5.6 0.98336 -0.25247 0 0 0 0 0 8.79883 0 0 0 0 0 0 0 0 0 A0A8P0NK00 A0A8P0NK00_CANLF Complement C3 C3 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; inflammatory response [GO:0006954]" extracellular space [GO:0005615] endopeptidase inhibitor activity [GO:0004866] AAFQNRPSST;AFRQPNSAF;AIRTLDPEA;AIRTLDPEAKG;AIRTLDPEAKGQE;AIRTLDPEAKGQEG;AIRTLDPEAKGQEGVQ;AIRTLDPEAKGQEGVQR;ALKTNKEL;ALKTNKELQ;DPMFSMITPNIL;DPMFSMITPNILRL;DPMFSMITPNILRLE;DPMFSMITPNILRLEN;DPMFSMITPNILRLENK;DPMFSMITPNILRLENKE;EETKKNENFEVIAKG;EEVHAADL;EEVHAADLG;EEVHAADLGD;EEVHAADLGDQ;EEVHAADLGDQVPDTE;EEVHAADLGDQVPDTESE;EEVHAADLGDQVPDTESET;EEVHAADLGDQVPDTESETR;EEVHAADLGDQVPDTESETRIL;EEVHAADLGDQVPDTESETRILL;EEVHAADLGDQVPDTESETRILLQ;EEVHAADLGDQVPDTESETRILLQG;EIKHHIVWDSPSLQ;ENFEVIAKG;ENFEVIAKGK;ETKKNENFEVIAKG;EVIAKGKGQGTL;FKPAMPFDLMV;FRQPNSAF;FVTNPDGSPAPHVPVG;FVTNPDGSPAPHVPVGIQN;GKDYAGVFMDAGL;GQGTLSVVTM;GQGTLSVVTMY;GSGKDYAGVFMDAGL;HIVWDSPSLQ;IIQGDPGARVGL;IIQGDPGARVGLVA;IIQGDPGARVGLVAVDKGVF;IKKGYTQQL;IRTLDPEA;IRTLDPEAKGQEGVQ;IRTLDPEAKGQEGVQR;IVWDSPSLQ;KDYAGVFMDAGL;KNENFEVIAKG;LDPEAKGQEGVQ;LIIQGDPGARVGL;LIIQGDPGARVGLVA;LNEQRYYG;LNEQRYYGGGY;LVWGVSTDLWGE;MVFVTNPDG;MVFVTNPDGSPAPHVPVGIQN;NENFEVIA;NENFEVIAK;NENFEVIAKG;NENFEVIAKGK;NFEVIAKG;NFEVIAKGK;NVNFHLRTD;PEKNGISTKTMNVFL;PGARVGLVA;PRMELKPGETL;PYSVAIAG;QVSINLPS;RLLLLLLL;SDMDEELFL;SEETKKNENF;SEETKKNENFE;SEETKKNENFEV;SEETKKNENFEVI;SEETKKNENFEVIA;SEETKKNENFEVIAK;SEETKKNENFEVIAKG;SEETKKNENFEVIAKGK;SEETKKNENFEVIAKGKG;SEETKKNENFEVIAKGKGQ;SEETKKNENFEVIAKGKGQG;SEETKKNENFEVIAKGKGQGTL;SGKDYAGVF;SGKDYAGVFMDAGL;SHLPGQQTTL;SRMDNLGLA;STEIKHHIV;STEIKHHIVWD;STEIKHHIVWDSPS;STEIKHHIVWDSPSL;STEIKHHIVWDSPSLQ;STEIKHHIVWDSPSLQR;SVVLTEKR;SVVLTEKRMDKVG;TAGSGKDYAGVF;TEIKHHIV;TEIKHHIVWD;TEIKHHIVWDSPS;TEIKHHIVWDSPSLQ;TKKNENFEVIAKG;TLAIRTLD;TLAIRTLDPEA;TLAIRTLDPEAKGQEGVQ;TLDPEAKGQEGVQ;TLDPEAKGQEGVQR;TVILHSGSD;TVILHSGSDM;VEMWPEADECQDEENE;VFQALAQYQKDVPNHKDLNL;VFVTNPDGSPAPHVPVGIQN;VGKSLYVSA;VIVPLKIGL;VKKILKVVP;VNMGQWKIQAHYEDA;VPNHKDLNLQVSINLPS;VWDSPSLQ;VYKTRLLRKEPAEDFDEYVMA;YAGVFMDAGL;YIPELVNMGQ 124 26.3 0 258.92 18.3785 18.4292 18.3995 18.0895 18.5278 18.7033 19.4199 19.6092 19.618 18.0747 17.978 17.9232 18.5542 18.6539 18.7436 A0A8P0NK13 A0A8P0NK13_CANLF Ciliosis and planar polarity effector complex subunit 1 CPLANE1 Canis lupus familiaris (Dog) (Canis familiaris) DKTITELHS;DLEVEFDSCMVEH;EETNEGNHFPNNL;EILRGSHLPVKENEDCSV;EQKGMIKAFSNPEH;HIRDKLSYNCRQYQK;IEEEDVNLLFGSVQEV;ISQEQHCLSPRRE;ISQEQHCLSPRRENKYGHNIPTN;LIVLWRVLYKKTLW;LNYCKGGVAFFRP;NKEAPSDRETSEAEFSVT;PQPVGEYTRE;QEKWSWNSSFKICP;RLYLYVSGNGKR;SEAWSVEEKRNT;VGQWSQIIPDEAVHLPSKED;VGSPVINPTRGS;VLSAAVPV;VLTTSSNDVWLA 20 8.4 0.94828 0.080139 0 0 0 0 0 0 0 0 0 0 0 0 9.35125 0 0 A0A8P0NK22 A0A8P0NK22_CANLF Tetratricopeptide repeat domain 4 TTC4 Canis lupus familiaris (Dog) (Canis familiaris) Hsp90 protein binding [GO:0051879] KYCPDNLEVYF;LVKALTPA;MRNDNTSCTCD 3 7.2 1.0029 -1.6604 4.96555 0 0 0 0 0 0 0 0 0 0 0 0 0 9.00907 A0A8P0NK39 A0A8P0NK39_CANLF Sperm associated antigen 5 SPAG5 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988] ESDEQSLDLN;HLEDCKGRIE;LVPSESNTSLPSSMF;NLQQDWISMQLDYIT;PGAFTTSGKGP;QEEVAQQTVSL;SRQLRDWKSQLT 7 7.7 1.0033 -1.6903 0 9.40984 0 0 0 0 9.99817 0 10.0459 0 5.89137 0 7.28605 0 0 A0A8P0NK79 A0A8P0NK79_CANLF Zinc finger protein 622 ZNF622 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit biogenesis [GO:0042273] ADAVDDVEEQDVEEEEAAGGPL;MLWVLLMTSVLNEEAFDVRIGGHDT;TGMKNNATKQMHFRPQ;YLSDLKGLIK 4 21.7 0.99194 -0.29238 0 0 0 0 0 0 0 0 0 0 0 0 0 19.2533 0 A0A8P0NK82 A0A8P0NK82_CANLF TNF receptor superfamily member 12A TNFRSF12A Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] plasma membrane [GO:0005886] LSYPGAPKKAAVIVEAGASCLIP 1 9.2 0.97886 0.046276 0 0 7.14547 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NK93 A0A8P0NK93_CANLF FYVE-type zinc finger domain-containing protein RPH3AL Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DHEAECDGEWPFPVS;RGGGHPAG 2 7.3 1.005 -1.0505 0 0 0 0 0 0 0 0 10.4546 0 0 0 2.417 0 0 A0A8P0NKC5 A0A8P0NKC5_CANLF Rab interacting lysosomal protein RILP Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] protein dimerization activity [GO:0046983] ALELLEKAAVGPD;VKKQRKKIKA 2 6 1.0026 -0.75925 0 4.27038 10.2648 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NKE1 A0A8P0NKE1_CANLF Zinc finger protein 205 ZNF205 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] YLSREEWGRLDHTQQ 1 2.7 0.98496 -0.24506 0 0 0 0 0 9.12055 0 0 0 0 0 0 0 0 0 A0A8P0NKF7 A0A8P0NKF7_CANLF "PPARGC1 and ESRR induced regulator, muscle 1" PERM1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] DTSPPSPATAQPS;EEEDEQAEEEAEAGQ;GPASQGPA;GTDLDLSTPVPTTEQ;LVSRSWHEPGLALGADQ;PDTPLSTP 6 10.2 1.0028 -1.7628 0 0 9.63019 10.0283 0 5.87059 0 0 0 5.74198 0 0 9.6598 0 0 A0A8P0NKF9 A0A8P0NKF9_CANLF "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta)" ACAP3 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] DEGKTPLVQAVL;FSTGSVVDSV;IDSATDSRERSVKGE;KVREDMELSL;VISECLQR;YSERLDRTASPSTSS 6 8.4 1.0023 -1.3975 0 0 13.3618 0 0 0 7.77617 0 0 0 10.0654 0 0 7.06781 12.5112 A0A8P0NKG1 A0A8P0NKG1_CANLF U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.-) METTL16 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; post-transcriptional regulation of gene expression [GO:0010608] U6 snRNA (adenine-(43)-N(6))-methyltransferase activity [GO:0120048] EGGELEFVKRIIH;EKSRKPITFVVL;ESEIIYDFCMCNPPF;HARNRYKDKPPDF 4 9.5 0.98778 -0.48413 0 0 0 9.10889 0 0 0 8.95402 0 0 0 0 0 0 0 A0A8P0NKI6 A0A8P0NKI6_CANLF ATP binding cassette subfamily A member 17 ABCA17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EAFTHKDNIPA;KYGAGYYMTL;LKLLLWKNFILKKRKP;MTLGRNLKLLLWKNFILKKRK;MTLGRNLKLLLWKNFILKKRKPLV;NLKLLLWKNFILKKRKPLVTML;TLGRNLKLLLWKNFILKKRKP;VFLHYKEEA;VGDPDKASESKFIQE;YGIPKPWYFFP 10 4.7 0.98707 -0.23001 0 0 0 0 0 0 0 10.3267 0 0 0 0 0 0 0 A0A8P0NKJ1 A0A8P0NKJ1_CANLF SplA/ryanodine receptor domain and SOCS box containing 3 SPSB3 Canis lupus familiaris (Dog) (Canis familiaris) ELGEGQHFWE;PVTGESFCDCDSQSEASLCGS;RCGEEDEHFDWVWDDL;YDSDGQHSDSDSDPESSALPP 4 20.5 1.0025 -0.73916 0 0 0 6.04153 0 11.0076 0 9.02092 0 8.19845 9.91255 0 12.2463 8.83482 0 A0A8P0NKL6 A0A8P0NKL6_CANLF Transmembrane serine protease 9 TMPRSS9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] AHCDCGLQ;GHGIPLAA;GVDVEHTAELQ;PECDDRVDCSDGSDEAHCD;PGILDFDAAILELARPLD;PLACEEAPGV 6 6.7 1.0041 -2.0238 9.59533 0 0 0 0 0 0 6.60425 0 11.0285 0 0 7.64854 0 6.35766 A0A8P0NKM6 A0A8P0NKM6_CANLF Pleckstrin homology and RhoGEF domain containing G5 PLEKHG5 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AYVTWAEKH;DEQEEEDEEDEDEEE;DEQEEEDEEDEDEEEEE;EDDEQEEEDEEDEDEEEEEG;EDEDEEEE;ELEGRTSCLAGE;FDHDSWEEEGDEEEEEDDA;FDHDSWEEEGDEEEEEDDACL;LEDSWRELIDGHEKLTRRQCHQQ;QEEEDEEDEDEEEEEGGGSSTSAA;RYCMEEEGCMEYM;TTLLLNSTL;VEAIYNAQNQ;YCMEEEGCME 14 12.4 1.0027 -2.5125 11.1738 0 10.6529 0 9.82048 6.69098 0 0 0 9.23621 4.64708 10.4196 8.9131 9.09745 12.0237 A0A8P0NKM9 A0A8P0NKM9_CANLF MOB kinase activator 3A MOB3A Canis lupus familiaris (Dog) (Canis familiaris) RLPGNRRARRRGRPFSGPRPPWAP;YYFVKEFGLID 2 9.3 0.98752 -0.26012 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.25227 A0A8P0NKN0 A0A8P0NKN0_CANLF Chromosome 5 C1orf159 homolog C5H1orf159 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGQQPECCVDMLATNTTCQGT 1 7.9 0.98441 -0.24705 9.58263 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NKN1 A0A8P0NKN1_CANLF FA complementation group A FANCA Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] MQICVLMVT;NLDDLLLEVEGPACKTLCLNQ;PLLSSLYRRLFVMLS;SALAGRSQELQGQGDPVG 4 4.4 1.0021 -0.65056 9.79097 0 4.31129 0 0 0 0 7.73748 0 7.65371 0 0 0 0 0 A0A8P0NKP8 A0A8P0NKP8_CANLF Proline rich 35 PRR35 Canis lupus familiaris (Dog) (Canis familiaris) HYIPRPWG;RPALLPRLYYPL 2 3.7 1.003 -1.3833 0 0 0 0 0 0 0 0 0 10.047 0 0 5.51602 0 0 A0A8P0NKR1 A0A8P0NKR1_CANLF Netrin G2 NTNG2 Canis lupus familiaris (Dog) (Canis familiaris) ASGDYDICKSWVTTDE;GGRGSCCGW;HCRLGYYRN;KEKHVRFEVRD;MGGGGKGG;NIEVIGRCKCNLHA;VAGKRAGPGLAG;VLCTEEYSRWAG 8 14.4 1.003 -2.1512 0 7.28077 0 0 0 0 0 9.26735 11.441 0 9.60248 10.4628 9.49801 11.2422 11.6153 A0A8P0NKR9 A0A8P0NKR9_CANLF Inactive rhomboid protein (iRhom) (Rhomboid family member) (Rhomboid veinlet-like protein) RHBDF1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein secretion [GO:0050709]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] serine-type endopeptidase activity [GO:0004252] FKLSAVVLFLF;FTPASFLEEDTADF;GHKRQFGSVCHQDPRV;LTFVHSLVT;VGRLTNRTYRKRIDSY 5 7.6 1.0001 -0.61677 0 8.54295 7.86666 0 0 0 0 8.43492 0 0 0 0 0 0 7.5678 A0A8P0NKS6 A0A8P0NKS6_CANLF Cadherin domain-containing protein LOC479600 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] AHQRTMRDQDTGKENEMDWD;CKVKQVAWK;FARAASEFESPEGV;HSSEEEEEEEEEEES;RQDPSEEKKYKPAEF;SEEEEEEEEEEESEDGEEE;SEEEEEEEEEEESEDGEEEDDIT;TYEDQHSSEEEE;TYEDQHSSEEEEEEEEEEES 9 8.9 0.99212 -0.13905 6.27756 0 3.50716 6.77926 8.56297 0 0 12.5335 0 8.38215 0 5.70692 6.53297 0 5.49611 A0A8P0NKT1 A0A8P0NKT1_CANLF Ubiquitin-associated domain-containing protein 1 (Kip1 ubiquitination-promoting complex protein 2) UBAC1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GAQFQYSLPNPRTPRQLF;HGSLEDPKSVTHHK;MSVPQAMEWL;SLMEMGFDEK 4 8.3 0.97879 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.18259 0 0 A0A8P0NKU3 A0A8P0NKU3_CANLF Choline/ethanolaminephosphotransferase 1 (EC 2.7.8.1) (EC 2.7.8.2) (EC 2.7.8.22) (1-alkenyl-2-acylglycerol choline phosphotransferase) CEPT1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid biosynthetic process [GO:0008654] endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" LVFYCPTATEQ;PLMQGYWEWLVGRVPSWIAPN 2 11.4 0.98938 -0.19658 0 0 0 0 0 5.2304 0 10.5009 0 0 0 0 6.47889 0 0 A0A8P0NKV1 A0A8P0NKV1_CANLF Differentially expressed in FDCP 8 homolog DEF8 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] REAQEVRSQPAE;SEETSEVASEEALPEL;VENDEMYSIQDLLDA 3 8.8 0.99597 -0.11381 0 3.38336 0 0 0 0 0 10.2454 0 0 8.56228 0 0 0 0 A0A8P0NKV8 A0A8P0NKV8_CANLF Myosin binding protein H like MYBPHL Canis lupus familiaris (Dog) (Canis familiaris) PGSSAHGVRSH;PKPKIIWLKNK 2 5.5 0.99005 -0.26631 0 0 0 0 0 0 0 0 0 8.82598 0 0 0 0 0 A0A8P0NKX1 A0A8P0NKX1_CANLF Actin related protein T2 ACTRT2 Canis lupus familiaris (Dog) (Canis familiaris) FVGEEALHK;TPIKITAPPD;VGEEALHKQEVL 3 6.1 1.0038 -1.6802 11.4422 0 0 0 0 0 0 0 0 7.09265 0 9.44931 0 0 0 A0A8P0NKX2 A0A8P0NKX2_CANLF Phospholipid phosphatase 2 PLPP2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] LCWKWARLLRPTVQFFLLA 1 6.6 0.95215 0.04941 0 5.85382 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NKZ6 A0A8P0NKZ6_CANLF MTOR-associated protein MEAK7 (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) MEAK7 Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764]; membrane [GO:0016020] VGDAPVLQQ 1 2 1.0043 -0.80421 0 0 0 0 0 8.24213 0 0 0 0 0 0 0 0 0 A0A8P0NL01 A0A8P0NL01_CANLF Lipocalin 12 LCN12 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] small molecule binding [GO:0036094] EDQFQGEWFVIGLA 1 7.3 0.9909 -0.2094 0 10.5945 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NL10 A0A8P0NL10_CANLF 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) AGPAT2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid biosynthetic process [GO:0008654] membrane [GO:0016020] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] AALLLLLLLVQL;ELLFLGPVGLIM 2 8.8 0.98931 -0.21651 0 0 0 0 0 0 0 11.848 0 4.41 0 0 0 0 11.5058 A0A8P0NL13 A0A8P0NL13_CANLF Interferon regulatory factor 8 IRF8 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976] KFKEGDKAEPATWKTRLR 1 4.2 0.98994 -0.26391 9.33199 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NL19 A0A8P0NL19_CANLF Chloride channel CLIC-like protein 1 CLCC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ECEKRKKEDY;MVLLCLLCIV;VTEPLKHIGKGAGEF 3 6.4 1.0036 -1.0365 0 0 11.6966 0 0 0 0 9.65735 0 0 0 8.32468 0 0 0 A0A8P0NL23 A0A8P0NL23_CANLF Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) SH3GLB2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] MDFNMKKLASDA;PSVTRARGCLS 2 5.2 0.99348 -0.076094 0 0 0 0 0 7.82757 8.89772 0 0 0 0 0 0 0 0 A0A8P0NL26 A0A8P0NL26_CANLF AKNA domain containing 1 AKNAD1 Canis lupus familiaris (Dog) (Canis familiaris) CSLTMTEENTSDI;KGTCRNADITMTLGKMT;NCETLPEIADADSSD;PSCHSASRTGLQSNKCENYG;RALERKENMEKKGHRRT 5 10.8 0.98748 -0.33527 0 0 8.81929 0 0 0 0 8.26261 9.64039 0 0 0 6.48483 0 0 A0A8P0NL30 A0A8P0NL30_CANLF Phospholipid phosphatase related 4 PLPPR4 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] AAVYVSMYFNSTL;PEETQENISTSPKSSSARAK 2 5.4 0.98754 -0.50164 0 0 0 0 0 0 0 0 8.95803 0 0 0 0 8.94942 0 A0A8P0NL43 A0A8P0NL43_CANLF Senataxin SETX Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] ADPLAGGDPTIHHLELATLKE;AKVSKERQELASKIKE;DDDDDEEE;IINNVSYNREIQNI;INNVSYNREIQNIRNS;ISDSDDDDDDDEE;ISDSDDDDDDDEEEE;ISDSDDDDDDDEEEEEE;ISDSDDDDDDDEEEEEEG;IVSPSADP;KIEVKKRKRKRF;SDDDDDDD;SDDDDDDDEEEE;SDSDDDDDDD;SDSDDDDDDDEE;SERNEDQPDI;VETPENQGEYCSKHCEAKAADEDVF;VGDGSERRDND;VGDPKQLPPTVISM;VIIISDSDDDDDDDEE;VISSLVTTQRKLK;YNKEESEQIERKSKKDLFCLENS 22 7.6 0.6 0.35809 0 4.63006 5.2532 6.43072 0 8.41878 0 7.07991 0 0 0 0 7.49865 0 0 A0A8P0NL45 A0A8P0NL45_CANLF Synapse defective Rho GTPase homolog 2 SYDE2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EDLKPPRIDSKDVFC;NKNELGVTEPPSPSP;TAAKRNVISRYH;VEPIHSSEFVQ 4 4 0.98724 -0.36352 0 7.71115 0 0 3.09385 8.96078 0 0 0 0 0 0 0 0 9.20882 A0A8P0NL49 A0A8P0NL49_CANLF Hemicentin 2 HMCN2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AQDAGAYICT;ASQHYIVQ;DDCHYNQLCENTPGSHRCSCPR;DECLEQSDDC;DGVSVLQGG;DTYLLAGG;EAPVLQGEAFSYL;EDSGTYVCWAE;EGDSGLYSCRAEN;EGLPVAESN;EQSDDCHYNQLCE;EQSDDCHYNQLCENTPGSH;FENPETERVSQVAGSPL;GEAFSYLVEPVGSSVQLDCV;GEILDLNCMAEGSPEP;GGRVLQIPLVRAED;GVALQGGGP;GVSNIDFRAGFSTQ;GVTVSADG;HVEIHMVPTIQ;KDHEGNPL;LDCEAQGSPPPLVT;PAEELAGVQVAS;PTFRQPPSSP;RAGHGAVYTRRAL;SDGPSPCSHS;VAPHGAGCEDVDECLE;VAVVRGSSVVL;VGSSVQLDCVVH;VLHIEQARF;VLSAVPYNLTWIRDWR;VTNTAGSQHRDVEL 32 6.7 0.99678 -8.0802 10.9685 12.8206 7.53013 5.6661 10.3896 8.03507 9.2744 11.6295 12.318 8.85717 8.71898 9.87722 0 13.7752 10.5017 A0A8P0NL54 A0A8P0NL54_CANLF Outer dense fiber of sperm tails 3 like 2 CIMAP1D ODF3L2 Canis lupus familiaris (Dog) (Canis familiaris) AYSLFWRPGPAS;PEETPGPG 2 7.2 1.0022 -1.3627 10.2917 0 0 0 0 0 0 0 9.29744 0 0 0 0 0 0 A0A8P0NL69 A0A8P0NL69_CANLF Transforming growth factor beta receptor 3 TGFBR3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; plasma membrane [GO:0005886] DTLTVMGIAFAAFV;ELYNTDLFL;FVFKSIFNTSL;HPVQALMESFTV;SLNYLAEYLQ 5 6.6 1.002 -0.76789 0 7.78653 0 0 0 0 11.6059 0 0 0 0 0 0 0 0 A0A8P0NL79 A0A8P0NL79_CANLF Torsin TOR2A Canis lupus familiaris (Dog) (Canis familiaris) chaperone cofactor-dependent protein refolding [GO:0051085] endoplasmic reticulum lumen [GO:0005788] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] FLFDEMDKL;GQHLAKALVVKA;LVVKALKAFVQ;VLDNPHHGF;VLDNPHHGFWR 5 11.8 1.0034 -1.6424 0 0 9.53002 4.11628 0 0 0 0 11.5994 0 0 0 0 0 0 A0A8P0NL93 A0A8P0NL93_CANLF Cadherin EGF LAG seven-pass G-type receptor 2 CELSR2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AGTVDEDSSGSDDE;ATQDVHFTENLLR;EVIQEQVQLTFSAG;EVRDVNAGPMRF;FITFRGLRQ;LEVIQEQVQLTFSAGE;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;PGPRSATAAVFLSVED;PLLLLLLLLL;PPLLLLLL;PPLLLLLLL;PPLLLLLLLLL;PPPPLLLLLLLLL;PTCGPCNCD;RAARAPLPTPPPPPLLLLLLLL;SEEEEEEEEEEAVFPG;SLSVGRPPGPGGGPPFLPSE;TPPPPPLLLLLLLLLLR;VTDTNDHD 21 5.4 1.0041 -2.024 11.1609 0 0 10.2346 0 4.3454 0 12.2751 0 6.14596 0 0 0 8.08167 7.02314 A0A8P0NLA3 A0A8P0NLA3_CANLF Zinc finger homeobox 3 ZFHX3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]" AATMCCLCQRSF;APTAATATISAP;AYSAPAPS;CNECSASFASLQTYME;CYKDEDEEGQDDS;EAEEEEEEEEAEEEEEEEEEEEEEE;EEEAEEEEEEEEAEEEEEE;FPFYIPSAEFQLNPE;GGGGGGGG;GGVGGGGG;GPVEPLPADLAQLY;LAAQQQGMFDN;LVSEELMNLGESFIQ;SLPEDEWKA;STEGDDGGFVPHHQHA;TDNLDMLGLHMNVERS;VGGGGGGG;VGGGGGGGG;VGLKKRVVQVWFQNT 19 5.8 0.99696 -4.6244 9.15421 8.90866 7.33602 9.35687 14.2858 0 8.97433 11.0429 9.05675 4.95108 11.3912 9.58742 0 9.69068 0 A0A8P0NLD2 A0A8P0NLD2_CANLF GB1/RHD3-type G domain-containing protein GBP1 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] GTP binding [GO:0005525]; GTPase activity [GO:0003924] DEYLENSLRLKQGTNE;IQRHNQQMMMQRERLYQEQIRQIQ;KTEELKAKYYQ 3 8.7 0.98551 -0.44626 6.85025 10.5713 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NLG9 A0A8P0NLG9_CANLF Leucine rich repeat containing 74B LRRC74B Canis lupus familiaris (Dog) (Canis familiaris) TGLKSLDLSYNQLNDQ 1 4.4 0.96082 0.049233 0 0 0 0 0 0 0 0 0 5.69215 0 0 0 0 0 A0A8P0NLJ0 A0A8P0NLJ0_CANLF Coiled-coil domain containing 160 CCDC160 Canis lupus familiaris (Dog) (Canis familiaris) ESSLFCCV 1 2.2 0.98997 -0.26592 0 8.31442 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NLK1 A0A8P0NLK1_CANLF Adhesion G protein-coupled receptor L4 ADGRL4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] AAYDSYGNV;CAFWNYSPDTMNGSW;CHLDNACIA;CQENVSADCH;DIKKEREGGRE;EGSYYCMCA;GGRKGPEEAASPGRAGP;GVEACYCNMGFSGN;GVEACYCNMGFSGNGVTICEDD;GVIYNKGF;GVTICEDDNECGNLTQPCGENAN;RTPQDAQVW 12 14.9 0.99745 -3.4015 0 0 5.76105 4.72961 0 10.3962 11.0347 5.99254 6.28963 5.31846 10.5621 0 4.41806 0 0 A0A8P0NLL5 A0A8P0NLL5_CANLF WD repeat and coiled-coil-containing protein WDCP Canis lupus familiaris (Dog) (Canis familiaris) KSSPVYPPSQDLP;LAVQHKNHVI;LVWTDGNQ;VHITYQKSYNV;VVASGSSL 5 7.2 1.003 -1.7101 12.7777 16.3297 14.2111 0 0 0 0 0 0 0 0 7.01246 0 0 0 A0A8P0NLN9 A0A8P0NLN9_CANLF von Willebrand factor A domain containing 5B1 VWA5B1 Canis lupus familiaris (Dog) (Canis familiaris) DVTSFVSGYAL;EWVFPETTE;GPSQTLLGEDSA;LPTVVGYPNSGAAW 4 3.7 0.99295 -0.17892 0 0 0 0 0 10.8305 0 0 0 0 10.1351 0 0 0 9.64043 A0A8P0NLP6 A0A8P0NLP6_CANLF SH2 domain containing 2A SH2D2A Canis lupus familiaris (Dog) (Canis familiaris) EVPPGAGGP;QEAASSPED 2 4.3 0.98965 -0.26542 0 0 0 14.8544 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NLR3 A0A8P0NLR3_CANLF Syntrophin beta 2 SNTB2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] structural molecule activity [GO:0005198] ILISKIFPGLAADQSRAL;LPNGGGAG 2 4.6 0.98939 -0.52005 0 0 0 0 9.94056 10.1124 0 0 0 10.5329 0 0 9.74579 0 0 A0A8P0NLW2 A0A8P0NLW2_CANLF Hepatitis A virus cellular receptor 1 HAVCR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PATLPCTYSTASGV;VGLAQLWGCYQFMRR 2 12.2 0.99151 -0.18627 0 0 0 0 0 0 0 0 0 11.178 0 0 9.9369 0 0 A0A8P0NLX1 A0A8P0NLX1_CANLF Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) SLC8A1 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] plasma membrane [GO:0005886] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] DDDDDECGEEKLPSCFDY;DERDQDDEEARREMAR;DQDDEEARREMA;FIEAITVSAGEDDDDDECGEE;GEDDDDDECG;GEDDDDDECGE;LGGFTITGQP;LTNTVFVDF;SAGEDDDDDECGE;SAGEDDDDDECGEEKLPSCFD;TVSAGEDDDDDECG;VGTNSWREQFIE;VITIAEEYDDKQ;WSIAAIYHAANGEQFK 14 10.5 1.002 -1.2795 10.9284 9.2181 10.6257 7.76971 0 11.2096 0 0 0 0 0 0 4.53667 0 7.49777 A0A8P0NLZ2 A0A8P0NLZ2_CANLF Abhydrolase domain containing 1 ABHD1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic ester hydrolase activity [GO:0052689] PVLCLNAADDPFSP;QPPRMPSSSQSP 2 6.1 0.91531 0.11135 0 0 0 0 0 0 9.14239 0 8.12159 0 0 0 0 0 0 A0A8P0NM04 A0A8P0NM04_CANLF Uncharacterized protein LOC607646 Canis lupus familiaris (Dog) (Canis familiaris) KDNTALHYAAYEGNIS;QEEACVDILLRKGADVNTKD;VSIAEKLL 3 8.4 0.99067 -0.14713 0 0 0 0 0 0 0 0 10.8928 0 0 7.76626 0 0 0 A0A8P0NM05 A0A8P0NM05_CANLF Receptor activity-modifying protein 1 RAMP1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] membrane [GO:0016020] coreceptor activity [GO:0015026] ELTDCTRHVADQLDCFWPNAAVDK;GALGGPTRPWGS;LGSVSPRLPLHMAG 3 25 0.98978 -0.52801 0 0 0 0 0 0 6.58472 0 0 0 0 0 0 0 0 A0A8P0NM22 A0A8P0NM22_CANLF G protein regulated inducer of neurite outgrowth 1 GPRIN1 Canis lupus familiaris (Dog) (Canis familiaris) DPTFIVKTE;ETVSSTEEDR;IVSGKAEPVVPAQAED;PTASGKAD;RALLQSVRRPR;VKTEPTSLENRNP 6 6.9 1.0035 -1.6528 10.4936 0 0 0 8.35231 5.69952 0 7.17443 0 0 0 7.47029 0 0 0 A0A8P0NM25 A0A8P0NM25_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein LOC481674 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] small molecule binding [GO:0036094] VLSECFLVWAPGSSL 1 7.7 0.9927 -0.065122 0 0 0 0 0 0 0 0 0 0 0 0 10.8557 0 0 A0A8P0NM26 A0A8P0NM26_CANLF Peptidase S1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DEMLCAGD;VLYRQRLSKSTAY 2 12.1 0.9482 0.059561 0 0 0 0 0 0 0 0 8.67849 0 0 0 0 0 0 A0A8P0NM30 A0A8P0NM30_CANLF Muscarinic acetylcholine receptor CHRM5 Canis lupus familiaris (Dog) (Canis familiaris) gastric acid secretion [GO:0001696] postsynaptic membrane [GO:0045211] G protein-coupled acetylcholine receptor activity [GO:0016907] ERTVPPDECQIQFL;HLGYWLCYVNSTVNPICYAL;VTLWHLGYWLCYVNSTVNPICYAL 3 7.4 0.98626 -0.42131 0 0 0 0 0 0 0 0 0 0 0 0 10.509 0 12.4459 A0A8P0NM35 A0A8P0NM35_CANLF Colony stimulating factor 2 receptor subunit alpha CSF2RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] CIQPHGSELPLCGM;GVPETPTPP;HGSELPLCGMLS;HQVGKGGG;SNREFKYQ;VQWDLTTVEGFPSL;WPERSLVQWDLT 7 11.3 1.0031 -1.9588 0 0 0 0 9.65589 0 0 0 10.1956 0 0 10.802 7.62585 11.0217 10.0845 A0A8P0NM36 A0A8P0NM36_CANLF Jupiter microtubule associated homolog 1 JPT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GAKSSGGI 1 5.4 0.98802 -0.2648 0 0 0 0 0 0 0 0 0 0 0 0 9.81258 11.3839 0 A0A8P0NM57 A0A8P0NM57_CANLF Olfactory receptor OR52AB4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AIFWFGSYS;IRATVLVGILPILLKRLQ;LAVLAATDLGLC;LSTIYLLVPPALN;LVGILPILLKRLQLF;VLMVAIRATVLVGILPILLKR;VLVGILPILLKRLQLF;VLVGILPILLKRLQLFHS 8 19.4 0.99097 -0.13768 0 9.97971 10.9956 0 0 5.41863 5.66266 5.3211 0 0 0 0 10.1324 4.18603 0 A0A8P0NM66 A0A8P0NM66_CANLF Leucine rich repeat containing 30 LRRC30 Canis lupus familiaris (Dog) (Canis familiaris) VLFLNMNCLTELP 1 4.3 0.94146 0.059731 0 8.5146 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NM73 A0A8P0NM73_CANLF Proline rich 9 PRR9 Canis lupus familiaris (Dog) (Canis familiaris) LSQTKCVE;LSQTKCVEVCP 2 10.2 0.98781 -0.48852 0 0 0 0 0 10.2022 0 8.908 0 0 0 0 0 0 0 A0A8P0NM85 A0A8P0NM85_CANLF Transcription factor JunD (Transcription factor AP-1 subunit JunD) JUND Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AERKRLRNRIAASKCRKRKLERI;DGAPGTAP;GVSSSGGG;LPPPLLLLALVLLLGN;LSHVNSGCQLLPQHQL;RIKAERKRLRNRIAASKCR;SSSGGGGS;VSSSGGGG 8 13.9 1.0021 -2.6047 10.0744 0 6.03009 8.67306 0 0 0 0 14.5889 14.5181 14.4741 14.6875 14.6757 9.2879 5.28285 A0A8P0NMA2 A0A8P0NMA2_CANLF Transcription elongation factor A protein-like 3 TCEAL4 Canis lupus familiaris (Dog) (Canis familiaris) ESQWRARESQKKKENRTRKRR;KLQNKGQPDDEGKQEKQGK 2 14.9 0.9895 -0.19972 0 0 0 0 0 0 0 0 10.4996 0 0 0 0 4.81445 0 A0A8P0NMA5 A0A8P0NMA5_CANLF Gem nuclear organelle associated protein 4 GEMIN4 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364]; spliceosomal snRNP assembly [GO:0000387] SMN complex [GO:0032797] ADGGAEPEPRWWAG;DKNKVLSGTLLSWGRKGLS;EAERDVSLT;KKALIIIWAKVLQP;LHRKLEQLDW;LMALPTTICH;PLCRGACV 7 7 1.0034 -2.4479 9.75108 7.08417 0 0 0 0 0 9.20472 0 0 9.34023 4.21164 0 7.26538 0 A0A8P0NMA8 A0A8P0NMA8_CANLF Very low density lipoprotein receptor VLDLR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869] membrane [GO:0016020] calcium ion binding [GO:0005509] AISVVSTDDD;AVGGYLMW;CDGDPDCED;CDGDPDCKDGSDEVNCPSR;CDGENDCDSGE;CDGENDCDSGEDEENCGN;CNGQDDCSDGSDELDCAPPTCGE;CNQEQDCRDWSDE;DCDSGEDEENCGNITCSPDEF;DCEDGSDENPEQCH;DGDEDCADGSDE;DKKICGDIDECQNPGICS;ENDCDSGEDEENCG;EVNCPSRTCRPDQFECEDG;GENDCDSGEDEENCG;GENDCDSGEDEENCGNITCS;GGGGGGGG;GQDDCSDGSDE;GQDDCSDGSDELDCAPPTCGEHEFQ;GYLMWRNWQHKNMKSM;IQWPNGIT;NNGQCVPNRWQCDGDPDCED;QCDGDPDCEDGSDEN;QDIIVYHE;YLMWRNWQHKNMKSMNFDNPVYLKT 25 24.3 0.99681 -4.3578 8.63343 7.59679 8.62234 6.24578 5.05033 0 7.10024 13.56 7.74342 10.0843 7.74766 10.0982 9.12915 2.22811 8.03 A0A8P0NMB8 A0A8P0NMB8_CANLF Olfactory receptor OR51L4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EFHHWISIPFCFFY 1 4.4 0.99016 -0.26656 0 0 0 0 0 0 0 0 0 10.8289 0 0 0 0 0 A0A8P0NMD2 A0A8P0NMD2_CANLF "Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase)" MARS2 Canis lupus familiaris (Dog) (Canis familiaris) methionyl-tRNA aminoacylation [GO:0006431] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825] ALEAVSSCVRQTNGF;GWYCASEE;GYPNAEFRAWWP;PSARAQAEDYAL 4 8.7 1.0024 -0.97278 9.11111 0 0 9.19059 9.32629 9.07095 0 0 0 9.42945 0 0 0 1.72997 0 A0A8P0NME0 A0A8P0NME0_CANLF Olfactory receptor OR51A4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SLHEPMYYFLSM;SYILILKTVLGIA;TPVRVAKIGIVLSLKSVLLVL 3 14.7 0.92729 0.10673 0 0 0 5.0836 0 0 0 0 0 0 0 0 2.0333 0 0 A0A8P0NMG8 A0A8P0NMG8_CANLF Glycogen synthase kinase-3 beta (EC 2.7.11.26) GSK3B Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977]; negative regulation of developmental process [GO:0051093]; negative regulation of signal transduction [GO:0009968]; regulation of cellular component organization [GO:0051128] cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FPQIKAHPWTKDSSG;LAYIHSFGICHRDIKPQ;SYTDTKVIGNGSFGVV 3 11.7 0.85303 0.14937 0 0 11.6096 0 0 6.16354 0 0 0 0 6.52136 0 0 0 0 A0A8P0NMH3 A0A8P0NMH3_CANLF Synaptonemal complex central element protein 1 SYCE1 Canis lupus familiaris (Dog) (Canis familiaris) synaptonemal complex assembly [GO:0007130] synaptonemal complex [GO:0000795] ESEAQRKHTMLQECKERISALNSQI;LEMVKKLQKAGSLE;LWKFHGPEQMAREIDTLDS 3 18.4 0.98496 -0.25921 0 13.9832 0 0 0 8.72659 10.3824 14.7492 0 0 0 0 0 0 0 A0A8P0NMJ5 A0A8P0NMJ5_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein folding [GO:0006457] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] VDCEPLGP;VSFELFAD 2 9.9 1.0035 -2.2088 7.3137 0 0 0 7.83042 0 0 8.7418 0 0 9.1579 0 0 0 0 A0A8P0NMK2 A0A8P0NMK2_CANLF 45 kDa calcium-binding protein (Stromal cell-derived factor 4) SDF4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi lumen [GO:0005796] calcium ion binding [GO:0005509] DGHVSWDEYKVKFL;DYMDPMNEYNALN;LSLPEFISLPVGTVE;TEDEFLSF 4 14.1 0.94567 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 0 3.8533 0 A0A8P0NMM1 A0A8P0NMM1_CANLF Olfactory receptor OR52A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IITLRAAILVAPGLVLIK;TDIALATTIMP 2 9.3 0.99006 -0.19633 0 0 12.4821 5.05719 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NMP6 A0A8P0NMP6_CANLF Uncharacterized protein KBTBD2 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] EKHKKRKKDKKKKKKRKHKSSKS;HKKRKKDKKKKKKRKHKS;KDKKKKKKRKHK;KEKHKKRKKDKKKKKK;KHKKKKKKEKHKKRKKDKKKKKKRK;KKRKKDKKKKKKRKHKS;LLLLLLRRPRP;PGNFWLMLQQK;PLLLLLLLRR;PPLLLLLL;PPLLLLLLL 11 16.7 1.0011 -0.92191 0 0 11.2895 0 0 6.22398 7.55136 0 0 0 6.51602 0 0 0 0 A0A8P0NMR0 A0A8P0NMR0_CANLF KRAB domain-containing protein ZNF746 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] IGGSGRGAREGVGGSGGGGS;PGGSGYPISLPQ;RRRRGRRRRRLPPGRAGQ;VRRRGVRRRVGRKTQIQVI 4 14.8 0.83664 0.19776 8.29513 0 0 0 0 0 0 0 0 0 0 0 0 8.06474 6.50243 A0A8P0NMR4 A0A8P0NMR4_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) UCHL3 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] ITEKYEVFRTE;SVAPSIDEKVD;VGPAKATSPSLRLRRWR 3 13.3 0.99278 -0.15084 0 0 9.68087 0 11.7825 0 0 0 14.7314 0 0 0 8.77274 0 0 A0A8P0NMT2 A0A8P0NMT2_CANLF Bardet-Biedl syndrome 12 BBS12 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein complex assembly [GO:0051131] chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524] DLVELEMGL;EQHGAATPNTYRCNDLVE;TANNQWINKPDGFLEQ 3 5.2 1.0024 -1.0168 0 0 0 0 0 0 8.2737 0 0 9.50924 0 0 0 0 0 A0A8P0NMU8 A0A8P0NMU8_CANLF MHC class Ib DLA-79 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DLRSWIVEDPVAQ;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;RTLLLLLLLLLL;SIIAGLVLLVITGAMLVGVVIW;TLLLLLLL 7 12.8 0.85688 0.17299 14.5349 0 4.57331 0 0 0 0 0 5.40756 0 0 0 0 14.1263 0 A0A8P0NMV2 A0A8P0NMV2_CANLF XK-related protein XKR9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] DLIVDIWVSVRFFY;LDVKIALFLLLFLWFLGILW 2 9.1 0.91292 0.10917 0 0 0 0 0 0 7.77762 5.77386 8.63438 0 0 0 0 0 0 A0A8P0NMW0 A0A8P0NMW0_CANLF Adrenoceptor beta 1 ADRB1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; positive regulation of heart contraction [GO:0045823] membrane [GO:0016020] beta1-adrenergic receptor activity [GO:0004940] AASDDDDDDDD;AASDDDDDDDDEDDA;DDDDDDDDEDDAGAGA;DDDDDDEDDAGAGAGAA;HWWRAGGDEARRCYNDPKCCD;IVLLIVAGNVLVIAAIAKTPRLQT;LMHWWRAGGDE;MHWWRAGGDEARRCYNDPKC;SDDDDDDD;SDDDDDDDD 10 14.5 0.9367 0.10011 0 0 0 0 0 6.42433 9.06156 0 0 0 0 0 0 0 0 A0A8P0NMW1 A0A8P0NMW1_CANLF Olfactory receptor OR10V10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVLLAVMAYDR;LFVAFLLLYLG;VLLQYGCCSLIYLRPSSSYS 3 12.6 0.9928 -0.17071 0 0 0 0 0 0 0 0 8.86555 0 0 0 0 10.4251 0 A0A8P0NMY8 A0A8P0NMY8_CANLF Inter-alpha-trypsin inhibitor heavy chain 4 ITIH4 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] DQSPDVLSAKV;FITNFSMIIEGVTYPGNIKE;GSEIVVVGKLRDQSPDVLSAKV;LTISQNKTKAHI;PSIPGEVLQ;QEKEFQSPKYIFHSFMERLWAYLTI;SEIVVVGKL;SEVAEKPVET;TGGIYADSVLTER;VLSAKVRGQLH 10 12.5 0.98793 -0.49354 10.0946 10.4037 11.0229 0 0 0 11.8062 0 13.9357 0 8.01408 0 8.26861 11.3983 9.36065 A0A8P0NMY9 A0A8P0NMY9_CANLF N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) METTL14 Canis lupus familiaris (Dog) (Canis familiaris) forebrain radial glial cell differentiation [GO:0021861]; mRNA destabilization [GO:0061157]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827] nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396] mRNA binding [GO:0003729]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] KYQDEGETDEDKMEEYKDELEMQQE;QFCMLKFHQNYI 2 7.3 0.93961 0.085978 0 0 0 0 4.86542 0 0 8.32382 0 0 0 0 0 0 0 A0A8P0NMZ0 A0A8P0NMZ0_CANLF Protein Churchill CHURC1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] zinc ion binding [GO:0008270] TRRAPPRVPAP 1 4.5 0.99031 -0.26734 0 0 0 0 0 0 0 0 0 0 0 11.6624 0 0 0 A0A8P0NN14 A0A8P0NN14_CANLF MANSC domain containing 4 MANSC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FINNPDNKTVSPFFV 1 4.4 0.95198 0.053886 0 0 7.39111 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NN20 A0A8P0NN20_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEGVYYCAAWEEHSHSCCP 1 13.1 0.95429 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.81519 A0A8P0NN38 A0A8P0NN38_CANLF Olfactory receptor LOC491653 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVRTKQIRERVLRV;HEITFGAC 2 7.1 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6822 A0A8P0NN39 A0A8P0NN39_CANLF Gap junction protein GJA3 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] connexin complex [GO:0005922] HIVRMEEKKKEREEELLRA 1 4.4 0.95302 0.04948 0 0 7.16752 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NN50 A0A8P0NN50_CANLF TERF1 interacting nuclear factor 2 TINF2 Canis lupus familiaris (Dog) (Canis familiaris) telomere capping [GO:0016233] shelterin complex [GO:0070187] VPSMTTGT 1 1.7 1.0048 -1.1044 0 0 0 0 9.62585 0 0 0 0 0 0 0 0 0 0 A0A8P0NN54 A0A8P0NN54_CANLF Olfactory receptor family 56 subfamily A member 3 OR56A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CTFMVMAY;NCFYAMESCTFMVMAYDRYVAIC 2 7.3 0.97858 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.23754 A0A8P0NN57 A0A8P0NN57_CANLF Immunoglobulin C1-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TDKNPDEDI 1 5.5 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 8.17318 0 0 0 A0A8P0NN60 A0A8P0NN60_CANLF FH2 domain containing 1 FHDC1 Canis lupus familiaris (Dog) (Canis familiaris) DQETMKLDECLQIFR;SSFRDAREEITI;VEQLTKKGTEDLPP 3 3.8 0.99692 -0.58853 0 0 0 10.1202 0 0 0 0 0 0 10.5373 0 0 0 15.5913 A0A8P0NN68 A0A8P0NN68_CANLF Cbp/p300-interacting transactivator 2 CITED2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] QQQQPQHAF;SGGTSGGGAGSGNGGGGSGG;TDFIDEEVLM;VNGGHPPSA 4 17.6 1.003 -0.86051 0 0 0 0 6.06473 0 0 0 0 0 11.1864 0 0 0 0 A0A8P0NN90 A0A8P0NN90_CANLF Glutathione hydrolase (EC 2.3.2.2) (EC 3.4.19.13) (Gamma-glutamyltransferase) (Gamma-glutamyltranspeptidase) GGT5 Canis lupus familiaris (Dog) (Canis familiaris) glutathione catabolic process [GO:0006751] membrane [GO:0016020] acyltransferase activity [GO:0016746]; glutathione hydrolase activity [GO:0036374] LDQCEQAQPLGT;LFFNGTEPLRAQDPFP;WRLWDPRSHLEIQN;YSPPPPAG 4 8.8 0.98759 -0.37759 0 9.10926 0 0 0 0 11.0585 0 0 0 0 0 8.85456 11.015 9.99605 A0A8P0NNA5 A0A8P0NNA5_CANLF Peroxisomal bifunctional enzyme (EC 1.1.1.35) (EC 4.2.1.17) (EC 5.3.3.8) (Multifunctional enzyme 1) EHHADH Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] peroxisome [GO:0005777] "NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" CLLSCCNCT;ELFMYLQKSGQARALQYAFFAE;IKLAQRISDQSLESRRLCNKP;LDIDEIASSTDRPHLVIG;LHGYGWPRHRGGPM;RPHLVIGTHFF 6 12.2 1.0028 -1.1586 9.17523 6.8535 0 8.26017 7.73268 0 0 10.0232 0 0 0 0 8.87486 0 0 A0A8P0NNB2 A0A8P0NNB2_CANLF SRY-box transcription factor 8 SOX8 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] VEDSDSDAPP 1 2.2 0.99985 -0.61146 0 0 0 0 0 0 7.62293 0 0 0 0 0 0 0 0 A0A8P0NND8 A0A8P0NND8_CANLF Zinc finger and SCAN domain containing 16 ZSCAN16 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QESGEPQRNG;QLWELCRQWLRPEYH 2 7.2 0.99357 -0.55755 0 0 0 0 0 5.76937 0 0 0 0 0 0 0 11.034 0 A0A8P0NNF0 A0A8P0NNF0_CANLF DNA helicase (EC 3.6.4.12) CHD5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] AKTKEGKGPGV;ARLPKRLVKKGKKLK;DDDDEEEEGGCEEEEDDHMEFCR;DEEEEGGCEE;DEMENEDEMSE;DEMENEDEMSEEEDG;DGVPREGLS;EEDDHMEFCRVCKDGG;IVRVELSQMQKKYYK;KKLKDKKEKKAKRKRKDD;LGKKSKRRRK;LPKKKKSK;NDMDEPPPFDYG;PKRLVKKGKKLKDDKQ;PRAYHLVCLDPELEKAP;QEDLARNLGKGKRIRKQV;RKKIKGSKDAKKKGKGRKVAGLK;RQHVLTRIGVM;SPNKKKKKKLKDKKEKKAKR;TVTIAPPL;VGLPKKKKSKKLKENR 21 12.4 1.0033 -2.2766 9.88963 7.99537 8.17518 0 6.36667 0 4.20406 13.341 0 0 9.32389 0 7.88154 7.48704 0 A0A8P0NNH9 A0A8P0NNH9_CANLF Chromosome 11 C9orf131 homolog SPATA31G1 C11H9orf131 Canis lupus familiaris (Dog) (Canis familiaris) ESPQISRSP;GLRAGDILTPQ;LDPLPEPQGGSSLGDSPR;SEVWWDVP 4 3.9 1.0027 -1.1827 0 0 0 0 9.7173 0 9.11993 8.71284 0 0 0 0 0 0 7.88661 A0A8P0NNI2 A0A8P0NNI2_CANLF Aspartate beta-hydroxylase ASPH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101] ADDLTYQDYDEPV;EQVIEDSGPQ;KRGHFASVWQ;PEIKEKVKKKKPKLLNKFDKTIK;QFLGHMRGSL;VIEDSGPQNT 6 9.5 0.97912 0.046253 0 0 0 0 0 0 0 0 3.46571 0 0 0 0 0 0 A0A8P0NNJ8 A0A8P0NNJ8_CANLF TRPM8 channel associated factor 1 TCAF1 Canis lupus familiaris (Dog) (Canis familiaris) DKPTKSITCLWGG;GRNQQRQEWEF;GWMHAGYPIM;LAHSGSDL;MATPSAAFEALMNGV;QLQEAFGWEPFIRLFTEYRNQTNL;SPGAPIGV;VTSVAGVYFTD;YHGCVIAAARYGR 9 12.3 0.99737 -3.8521 12.3972 13.5668 0 0 0 0 0 0 7.92368 7.65971 10.5647 7.90701 12.818 0 10.2291 A0A8P0NNK3 A0A8P0NNK3_CANLF Glycoprotein Ib platelet subunit beta GP1BB Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] membrane [GO:0016020] LLHALLLLLLLCRLR;QLLLLGLGLLHALLLLLLL;QLLLLGLGLLHALLLLLLLCRLRR;WGALGAQLLLLGLGLLHALLLL 4 14.9 0.85294 0.19129 5.24808 0 4.99571 0 0 4.80105 0 0 0 0 0 0 0 5.90802 7.22843 A0A8P0NNK9 A0A8P0NNK9_CANLF C-type lectin domain-containing protein LOC484865 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate binding [GO:0030246] AEQKFLSP 1 4.3 1.0034 -1.1044 0 0 0 0 0 0 0 0 0 10.0362 0 0 0 0 0 A0A8P0NNL1 A0A8P0NNL1_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SMG1 ARL6IP1 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" protein serine/threonine kinase activity [GO:0004674] DVPPPSVSLPKL;EYAVAKSILTLAKWI;LDQLENCQTCGTDYI;LPTKTKPKKLLFL;NIETALGVTGVEGVFRLSCE;NNLEATQLASLLQEISSQ;NSYAVSVWKRVK;RLIRQVERLKQE;TASLEEQLQ;TISLSTESQASGNKFSSAIP;TKPKKLLFL;TQDMSTQRAIQTEKEQQ;TVHIGVGEPDFILGQLYHLSSVQ;VGGTITILPTKTKPKKLLFL;VPRPSELYYSKIG 15 5.6 1.0033 -1.5756 0 7.04603 8.45709 11.5047 0 5.51447 10.9318 0 0 6.95571 0 7.36186 10.2235 8.27006 8.98556 A0A8P0NNL5 A0A8P0NNL5_CANLF Primary cilia formation LOC609816 Canis lupus familiaris (Dog) (Canis familiaris) FGKAESLVNYPFG 1 6.8 0.98323 -0.25207 0 0 0 0 0 0 0 0 0 0 0 9.44439 0 0 0 A0A8P0NNM1 A0A8P0NNM1_CANLF Proteasome subunit beta type-3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] nucleus [GO:0005634]; proteasome core complex [GO:0005839] MSMVANLLYEKRFGPYYTEPFS 1 17.1 0.97505 0.048063 0 0 0 0 0 7.52576 0 0 0 0 0 0 0 0 0 A0A8P0NNN5 A0A8P0NNN5_CANLF "Centriole, cilia and spindle associated protein" CCSAP Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] GVKSEYMKRYREPRWDEYGPCYRE 1 9 0.97389 0.041303 0 0 0 0 0 7.89148 0 0 0 0 0 0 0 0 0 A0A8P0NNN7 A0A8P0NNN7_CANLF Zinc finger protein 484 ZNF484 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CGKAFTRK;DICSHSHHDGDIGFETS;IHQKCHTGERHYECS;THTEENHCKCSEY 4 7.2 1.0027 -1.3545 0 0 0 0 0 0 11.0445 0 0 9.07436 0 0 0 0 0 A0A8P0NNP6 A0A8P0NNP6_CANLF Olfactory receptor family 10 subfamily H member 5B OR10H5B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MYLFLCTLSISEILY 1 4.8 0.94554 0.084314 0 0 0 0 0 0 0 10.0804 0 0 0 0 0 0 0 A0A8P0NNR4 A0A8P0NNR4_CANLF DUF5523 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DHLQTFAEGQDEDFME;EESGEIMSLPSPIRQSWNFR;IDNICHELYYIDFLI;KAAEYEDDQEKIKKQ 4 23.1 0.9507 0.05389 0 6.61282 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NNS2 A0A8P0NNS2_CANLF Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Brain and muscle ARNT-like 1) ARNTL Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; PML body [GO:0016605]; transcription regulator complex [GO:0005667] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] EHQGRIKNAREAHSQIEKRRRDKMN;SGMDCNRK 2 5.4 1.004 -0.80974 0 0 9.00248 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NNS7 A0A8P0NNS7_CANLF RB transcriptional corepressor 1 RB1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] APRRAAAAAAEAPPPPPPAPE;ESLAWLSDSPL;KDLPHAVQ;QPSENLISYFNNCTVNP 4 6.2 0.97447 0.047166 0 0 0 0 0 0 8.97062 0 0 0 0 0 0 0 0 A0A8P0NNV4 A0A8P0NNV4_CANLF von Willebrand factor C and EGF domains VWCE Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] CFQCWCQNGEVTCEKVTCE;DCCSSCPDSL;DGGCCPSC;GNQHSCVDVNECRRP;LDDNGVEFPIGQIWSPGDPCE;NTVGSFLCTCRP;PIPSEDGGCCPSCAGC;SLSSAPTQLLA 8 11.8 1.0031 -1.5227 13.0352 13.1434 13.4073 12.4367 12.8369 12.7305 13.3379 12.825 13.3439 13.5136 13.5936 13.683 13.6695 13.3875 13.6747 A0A8P0NNW2 A0A8P0NNW2_CANLF Kinesin family member 1B KIF1B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; microtubule [GO:0005874]; synapse [GO:0045202] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AGLPCQGTFLLHQGI;CNEEMSYSVEVS;DIEEIRPGS;DITELADEQQDEMEDFDDEAFVDDT;DLFSDGHDPFY;DTSVAYVRGEEN;EMEKRLQEMEILYKKEK;EQQDEMEDFDDEAFVDD;KSSHNSSRTFYRFEAVWDSSLH;LADEQQDEMEDFDDE;SELHWKDVREL;SFDNEYFNQNDF 12 8.2 0.99316 -0.1327 8.3132 6.66448 11.4986 0 0 7.22004 8.22973 0 6.71273 8.43842 0 6.27266 0 6.86629 6.59997 A0A8P0NNW7 A0A8P0NNW7_CANLF SCP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NESKYFKYGE 1 5.3 0.99115 -0.14782 0 0 0 0 0 0 0 0 0 0 0 12.3675 0 0 0 A0A8P0NNX0 A0A8P0NNX0_CANLF Peroxisomal biosis factor 5 like PEX5L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KGDFEVVGVTLKKK;TSNTAVLTTGLDLLDLSEPV 2 9.5 0.9333 0.060813 0 0 0 0 0 0 0 7.49113 0 0 0 0 0 0 0 A0A8P0NNX6 A0A8P0NNX6_CANLF APC down-regulated 1 like APCDD1L Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178] plasma membrane [GO:0005886] Wnt-protein binding [GO:0017147] ERDVTATNGCLPLG;GIRLPHVEYELFRMELD;SLLIKGKVRLRRA 3 8.6 0.99729 -0.10673 0 8.83494 0 0 4.02707 0 0 0 10.2553 0 0 0 0 0 0 A0A8P0NNX8 A0A8P0NNX8_CANLF Protein AMBP AMBP Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] serine-type endopeptidase inhibitor activity [GO:0004867] AVLPQEEE;AVLPQEEEG;GAPGAGDEEL;GAPGAGDEELL;PGAGDEELL 5 5.7 0 5.304 0 11.2837 11.9647 9.2141 12.0483 11.5388 11.9281 11.948 12.0532 11.9212 12.256 12.3914 11.5082 0 9.49025 A0A8P0NNY7 A0A8P0NNY7_CANLF Glycoprotein 25L TMED11 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ESRRGTFKTQQWD 1 6.4 0.94112 0.05986 0 0 0 0 0 0 0 0 12.1832 0 0 0 0 0 0 A0A8P0NNZ9 A0A8P0NNZ9_CANLF RAS protein activator like 1 RASAL1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] SRWTCCLRAE;TTYLQCKNVNELNQW 2 3.1 0.99347 -0.13195 0 0 0 0 9.1693 0 0 0 0 0 0 0 0 0 5.95182 A0A8P0NP01 A0A8P0NP01_CANLF KIAA0586 KIAA0586 Canis lupus familiaris (Dog) (Canis familiaris) smoothened signaling pathway [GO:0007224] DSCASHGPMSLEEL;KSPLETPAPRRFAPIPV 2 2.2 0.93425 0.10731 4.20359 0 0 0 0 0 0 0 0 0 0 0 8.21597 0 0 A0A8P0NP04 A0A8P0NP04_CANLF Zinc finger protein 782 ZNF782 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECGKSCSMNSFLI;TENRNNFSKIT 2 3.3 0.92445 0.095172 0 0 0 5.35653 0 0 9.81245 0 0 0 0 0 0 0 0 A0A8P0NP10 A0A8P0NP10_CANLF Interleukin-1 IL1RN Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] DVNQKTFYLRNNQLVAGYLQG;EEAMMVTKFYFQK 2 21.5 0.91756 0.1098 0 0 0 0 0 0 0 7.16962 0 0 0 8.64537 0 0 0 A0A8P0NP16 A0A8P0NP16_CANLF SERTA domain containing 4 SERTAD4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GQFYDYFETGYN 1 3.6 0.9478 0.05044 0 0 0 0 0 0 0 8.59731 0 0 0 0 0 0 0 A0A8P0NP29 A0A8P0NP29_CANLF Metabotropic glutamate receptor 3 GRM3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EFTCMDCGLGQWPTAD;ENIPLLIAGV;RDSSMLISLTYDVVL;WLAFLPIFYVTSSDYRV 4 7.2 1.0019 -0.67347 0 0 0 0 0 9.0617 7.79961 10.6604 8.5108 0 0 0 9.76266 0 0 A0A8P0NP31 A0A8P0NP31_CANLF KN motif and ankyrin repeat domains 3 KANK3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] DLSSRTLPSRVPFFLTPQ;PGAQGRCELSP;PGAWTSSESLASDDGG;SRRGEGALEVPDAA;YESSSSEDDSDSDSEDGAA 5 8.2 0.99203 -0.55058 0 6.25524 0 0 0 0 8.15015 0 0 0 8.64854 0 0 0 0 A0A8P0NP41 A0A8P0NP41_CANLF RRM domain-containing protein LOC480188 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] NERNARAAVAGEDGRMI;SEGGADDSAEEGDRL;SLEKIEKEQ;VGCSVPKGF 4 17 1.0017 -0.75034 0 0 0 0 0 0 0 0 6.13857 0 0 0 0 5.2116 0 A0A8P0NP47 A0A8P0NP47_CANLF HECT domain-containing protein LOC100688587 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] ubiquitin protein ligase activity [GO:0061630] AVYEEFQRGFYK;FEEMTQPEYGMFTYPEDA;GVKVEFFHCVFEEMTQPEY;SVLYLPKYPTM;YGDAYRRSSWKYPVIF 5 12.2 1.0026 -0.75664 12.1843 0 8.27254 0 6.84574 0 0 0 0 0 0 7.29131 0 0 0 A0A8P0NP74 A0A8P0NP74_CANLF Zinc finger protein 175 ZNF175 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SHKQSHSQHQIRNQEKPD 1 2.6 0.97804 0.048313 7.02248 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NP78 A0A8P0NP78_CANLF Cellular inhibitor of PP2A CIP2A Canis lupus familiaris (Dog) (Canis familiaris) KLSTLASKESRLQDL;KLSTLASKESRLQDLL;KNKDLQTTCDSLNKQI;REDKEETI;SDIMDVYEMKL;SEDELTMP;SHMIAMIHSLSGGKISPE 7 8.3 1.0032 -2.4554 5.94378 13.8108 0 10.6683 0 9.34594 0 0 0 0 9.40094 0 0 0 0 A0A8P0NP82 A0A8P0NP82_CANLF Cylicin 2 CYLC2 Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of cytoskeleton [GO:0005200] ESTVLKEPKITKTKPMK 1 3.8 0.97961 0.046227 0 0 0 0 0 0 0 0 0 4.63599 0 0 0 0 0 A0A8P0NP96 A0A8P0NP96_CANLF Olfactory receptor OR6AE1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PKLLAGLLARARTISF;PVFYCLRNRD 2 8.4 1.0035 -0.83534 0 0 7.28827 0 0 0 0 0 9.94641 0 0 0 0 0 0 A0A8P0NPB0 A0A8P0NPB0_CANLF Translocation protein SEC62 SEC62 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] EEEEEEDNDGETTKSS;EQQTDGDCEEEEEEDNDGE;TPKKKETKKKFKL 3 10.2 0.98694 -0.23513 0 0 0 0 6.51572 0 0 0 0 0 5.18816 0 0 0 0 A0A8P0NPB2 A0A8P0NPB2_CANLF Ryanodine receptor 1 (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) RYR1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] sarcoplasmic reticulum membrane [GO:0033017] calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; ryanodine-sensitive calcium-release channel activity [GO:0005219] AEGDEDENMVYYFLEE;DMLVESSSNVEMI;EDEEKEEEETAEGEKEED;EEEKEEDEEEEAQEKEDE;EEKEEDEEEEAQE;EEVRQDLLEFH;ENEMINCEEFAN;GECLARLAAAMPVAFLEPQ;GGEGWGGNGVGDDLYSYGF;GGSVCTHARSLWRLEPLRISW;LVEDYLYMAYADI;PAVFVLPTHQN;PEENRVHLGHAIMSFYAAL;PLYNLPTHRACN;QDLLEFHQ;QEFIAHLEAVVSSGRVEKSP;QENHIKSIISL;SFPSNYWDKFVKRKVLDK;SLCVCNGV;SLLEKVRLVKKK;SLLGHYNN;SLRRRVRRLRRLT;TEEEEEEEEEEEEEEDEE;TIFEMQIAAQISEPEGEPEADDDDG;TTTYYYSV;VGFFQSIQALMQTCSVLDLNAFERQ;VGLQEDATGEACWWT;VSAVLYHLEQIE;VVRWAQEDFVQSPELVRAMFSLLHR;WNPCGGER 30 8.4 0.99682 -5.5986 11.0564 9.32746 0 8.44045 9.99039 10.0753 12.0603 9.65496 11.0656 4.00414 4.54368 11.5948 0 11.9719 10.0132 A0A8P0NPC1 A0A8P0NPC1_CANLF Coenzyme Q8B COQ8B Canis lupus familiaris (Dog) (Canis familiaris) AASIGQVHQGTLRDGTEV;RLCLRELFEF 2 5.6 0.99502 -0.56314 0 0 0 0 0 0 0 0 0 1.7909 0 6.55899 0 0 0 A0A8P0NPE2 A0A8P0NPE2_CANLF Pyruvate kinase (EC 2.7.1.40) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] SKFYKHMCLLDMDSPPI 1 5.7 0.97679 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5806 A0A8P0NPE8 A0A8P0NPE8_CANLF NK2 homeobox 8 NKX2-8 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" ALGLFPAYQHLAPPA;ESSPETSP;GGGGGGGA;LLRRVVVPV;PGGGGGGG;RAPGAPGAMEPPDLAAP 6 15.5 1.0017 -1.4659 8.11946 0 0 8.46634 3.95336 0 0 0 11.4939 0 0 9.04805 0 0 0 A0A8P0NPG4 A0A8P0NPG4_CANLF Nuclear Testis protein N-terminal domain-containing protein NUTM1 Canis lupus familiaris (Dog) (Canis familiaris) AEKFLEFE;ETLQPACPGN;PRAVQEWEHTSNFDRMIFYEMAEKF;SHSGSDEDEDGG 4 4.8 0.98776 -0.46442 0 0 0 0 0 0 10.4738 0 0 0 0 0 3.61235 0 0 A0A8P0NPH1 A0A8P0NPH1_CANLF Cation channel sperm associated 1 CATSPER1 Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317] CatSper complex [GO:0036128] calcium-activated cation channel activity [GO:0005227] GVHHHHESHHHSGSPHH;HHHGGSPH;LAEMAQKEADTN 3 4.3 0.9942 -0.079451 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.9788 A0A8P0NPH7 A0A8P0NPH7_CANLF cAMP responsive element binding protein 1 CREB1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GVPRIEEEKSEEE;QPSVIQSPQVQ 2 10.3 0.98632 -0.39177 0 0 10.2938 0 0 0 0 0 10.9441 0 0 0 0 0 0 A0A8P0NPI0 A0A8P0NPI0_CANLF Shisa like 1 SHISAL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLSAHFRVCEPYT 1 6.5 0.93761 0.05984 0 0 0 0 0 0 9.16794 0 0 0 0 0 0 0 0 A0A8P0NPJ3 A0A8P0NPJ3_CANLF Homeobox containing 1 HMBOX1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] double-stranded telomeric DNA binding [GO:0003691] DKFGRRSSYGGSSYGNSTNNVPASS;LETLDRLDQEH;YSFEASEEDLDV 3 15.8 0.99036 -0.14718 0 0 8.54346 0 8.53356 0 0 8.75492 0 0 0 0 0 0 0 A0A8P0NPJ4 A0A8P0NPJ4_CANLF Actin related protein 3B ACTR3B Canis lupus familiaris (Dog) (Canis familiaris) AGRDITYFIQQLL;IDVGYERFLGPEI;PKPVEVQVI 3 10.6 0.98457 -0.25726 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0876 A0A8P0NPK1 A0A8P0NPK1_CANLF Transmembrane protein 31 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IQQPEEQRTPGGQRTR;VLSTLHSYLPF 2 16.9 0.99079 -0.21018 0 0 0 0 0 8.79883 9.14692 0 0 0 0 0 0 0 0 A0A8P0NPK2 A0A8P0NPK2_CANLF TAFA chemokine like family member 4 TAFA4 Canis lupus familiaris (Dog) (Canis familiaris) EVVAVHRCCNK;SQTVKCSCFPGQVAGTTRA;SSQHPRGHAGHHQIKQ 3 33.6 0.98882 -0.30794 0 12.0561 0 0 11.8279 0 0 0 0 0 0 0 7.25776 0 0 A0A8P0NPK7 A0A8P0NPK7_CANLF CASP8 and FADD like apoptosis regulator CFLAR Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] IDWSGVLLL 1 3.7 0.99121 -0.26992 0 0 0 0 0 7.657 0 0 0 0 0 0 0 0 0 A0A8P0NPM0 A0A8P0NPM0_CANLF Keratin associated protein 16-1 KRTAP16-1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] PSCSMNSCAQPVCCEA;TSTTCEPSCAVSSCAQPVCYEA;VTSISYRPACY 3 13.2 0.98507 -0.25923 0 0 0 0 0 0 0 0 17.7327 0 15.0479 0 13.2275 0 0 A0A8P0NPP3 A0A8P0NPP3_CANLF Collagen type XV alpha 1 chain COL15A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] AGEPGPPGPE;ERVTLSVDA;FAVIVQGEEVT;FSGHGGQFNAQVP;NLSVSLHSIPE;VEDGGQRVILYYTEP 6 5.1 1.0026 -1.3419 0 0 9.8908 0 0 0 13.8343 8.20144 0 8.17752 0 8.96151 0 0 0 A0A8P0NPP6 A0A8P0NPP6_CANLF ATP binding cassette subfamily F member 1 ABCF1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DEEEITKEKEPPR;SQAEVSSRQAMLE;VEEQSVSQIDGDFE 3 5 0.86471 0.18047 0 0 0 0 0 0 0 0 0 0 0 8.22983 3.44228 11.1595 0 A0A8P0NPQ9 A0A8P0NPQ9_CANLF C1q and TNF related 12 C1QTNF12 Canis lupus familiaris (Dog) (Canis familiaris) EPGLRPVHSSNDCHL 1 3.2 0.94959 0.05389 0 0 0 0 0 0 0 0 0 0 0 0 8.71325 0 0 A0A8P0NPR1 A0A8P0NPR1_CANLF Transmembrane protein 178B TMEM178B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PVDECSRQYN 1 3.4 0.99978 -0.61146 0 4.87322 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NPR8 A0A8P0NPR8_CANLF C2H2-type domain-containing protein LOC484933 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECNVCGKVFMRHS;ETLRNLASI;EVKPWECNVCGKVFMRHS;HERNHSVEKSYKCKE;PSSLRKHERTHTG 5 9 0.99233 -0.28675 0 7.41151 10.0863 0 8.69439 0 0 0 0 0 0 0 0 0 8.59119 A0A8P0NPS4 A0A8P0NPS4_CANLF C2H2-type domain-containing protein ZNF502 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QEYNFERSLLLTS 1 2.4 0.98383 -0.25255 0 0 0 0 0 0 0 10.2427 0 0 0 0 0 0 0 A0A8P0NPT0 A0A8P0NPT0_CANLF Ubiquilin 3 UBQLN3 Canis lupus familiaris (Dog) (Canis familiaris) AGLGNMAG;EGALMPEDPPLAPAPEVPP;ESIPGGYNVL;FLNPEANLQ;LNPEANLQALIATGGDVDAA;PAASVPAP;QMLQALVGANPQQLQPE;QPEIHFRVQ;SANRAPFVPSPLSSVAATL 9 16.5 0.99903 -2.9672 10.1292 9.59971 0 11.3689 0 9.97298 0 8.95661 0 0 8.17552 11.069 0 10.3018 0 A0A8P0NPU1 A0A8P0NPU1_CANLF Nucleolar protein interacting with the FHA domain of MKI67 NIFK Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] RNA binding [GO:0003723] EDNEIVFKQ;FKKKEKLLRKKLAKKGI;KKKKKKKK;LPKKKKKKKKK;VLPKKKKKKKK;VLPKKKKKKKKK;VLPKKKKKKKKKSSR 7 13.8 0.87694 0.13981 0 0 0 0 0 0 0 5.34575 0 0 0 0 4.74545 0 7.06523 A0A8P0NPU3 A0A8P0NPU3_CANLF Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) VARS1 Canis lupus familiaris (Dog) (Canis familiaris) valyl-tRNA aminoacylation [GO:0006438] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] AFLREVWK;CIPPPNVTGSL;GTMPDSYSPQYVE;TGAVKITPA;VAVLALGAP 5 4.1 1.0034 -2.0601 0 5.91047 0 0 0 0 0 6.07925 0 0 0 0 0 0 10.3097 A0A8P0NPU8 A0A8P0NPU8_CANLF 3CxxC-type domain-containing protein RTP5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCDDGCCAP;DLCCDDGCC 2 2 1.0035 -1.6084 0 0 0 0 0 0 0 2.21652 0 6.57628 0 4.72088 0 0 0 A0A8P0NPY4 A0A8P0NPY4_CANLF Ig-like domain-containing protein LOC100686047 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] QVQVFVSPRSLPGSVHF 1 9.2 0.97676 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 5.57189 0 A0A8P0NPY6 A0A8P0NPY6_CANLF Integrin subunit alpha 9 ITGA9 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EELVVMGAPGSFYWAGTVKV;EETCHHYVAHVKRRVQD;GPAGSFFGYAVL;GSFSRPFTTDVVGGAPQDEG;ISLLVGILIFLLLAVLLWKV;VGQITEKLQLVYMEET 6 10 0.97267 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.53094 A0A8P0NPY9 A0A8P0NPY9_CANLF Carboxypeptidase E CPE Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020]; transport vesicle [GO:0030133] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] LALCGALAACGWLL;NSLVRYLE;PEESLRSYW;PVRVLLSPGP;QNTKLAPE;VIHWIMDIPFVL;VIIIILINILIPELKMRDRRRR;VRVLLSPGP 8 12 1.0027 -2.4688 0 10.1109 0 0 0 11.7537 8.63923 0 0 0 15.5211 11.2294 0 9.03582 7.16098 A0A8P0NPZ1 A0A8P0NPZ1_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2G2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] ATP binding [GO:0005524]; transferase activity [GO:0016740] SEAHPGAHADTAPS 1 6.2 0.98343 -0.25549 0 0 0 0 0 0 8.2502 0 8.10386 0 0 0 0 0 0 A0A8P0NPZ2 A0A8P0NPZ2_CANLF EF-hand domain-containing protein SLC25A24 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743] calcium ion binding [GO:0005509] EEEKRSGDWWR;GLVDIVELQEGLRN;GVNSGAEIFKAGNT;LFQNLDRDGDGLVDIVELQEGL;NDGIIETSEII 5 12.6 0.98893 -0.20297 12.8757 0 0 0 9.48706 0 0 0 12.8628 11.4236 0 0 0 8.49273 0 A0A8P0NQ14 A0A8P0NQ14_CANLF Transcription factor BTF3 Canis lupus familiaris (Dog) (Canis familiaris) HFNNPKVQ;TITGQAGTKQWTEMLPGILNQ 2 21.2 0.98418 -0.23812 0 0 0 0 0 0 0 0 0 0 0 0 8.5741 0 0 A0A8P0NQ16 A0A8P0NQ16_CANLF Pleckstrin homology domain interacting protein PHIP Canis lupus familiaris (Dog) (Canis familiaris) DCLVKIWATDDGRLLATLRGHAAEI;EEEERAWHSDG;EEERAWHSDGS;FLIARFLEDGPCQQAAQ;MYCTVVAYPTDLSTIKQRLENRFY;NPRPAKFTERPRP;PEYPDSLFQCYNV;QEIPQSVPGV;SPKKKKPKERKQKRLAVGE;TSEVHSPP;VDLQAYPMYCTV;VKRGPGRKPKVEV 12 8.8 1.0034 -2.2511 4.63471 6.10094 10.792 8.6268 8.53636 0 0 0 12.6581 0 11.991 0 0 7.66995 8.89312 A0A8P0NQ43 A0A8P0NQ43_CANLF Selenoprotein T SELENOT Canis lupus familiaris (Dog) (Canis familiaris) IASFLSVFKLVLIGLIIV 1 9.5 0.97263 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.75814 A0A8P0NQ49 A0A8P0NQ49_CANLF Cysteine and serine rich nuclear protein 3 CSRNP3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AEELDCQGEEEEEEEDGSSFC;EDEDEEEE;SESEEEEEEEDEDEEEEEDEEDD;TSVPSQGG;TVESEEASTLT 5 10.8 0.93481 0.093419 0 0 0 0 0 0 0 0 0 0 0 0 0 8.24902 5.44712 A0A8P0NQ71 A0A8P0NQ71_CANLF Uncharacterized protein LOC100685462 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] QRVRPGERCYMCSE 1 2.6 0.94188 0.061093 0 11.9714 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NQ94 A0A8P0NQ94_CANLF Mab-21-like HhH/H2TH-like domain-containing protein MAB21L4 Canis lupus familiaris (Dog) (Canis familiaris) AAIVHCRHQSL;HDLDPRFLVDYSRDLE;IVGQEVALV;LFPAPEDWAELQ;LVEEVGAAEAGDGPAS 5 14.6 1.0013 -0.93597 0 0 0 0 0 7.30415 0 0 9.96852 0 0 10.6799 0 7.93887 0 A0A8P0NQ98 A0A8P0NQ98_CANLF Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) QPRT Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514] GVGVSISI;SGVASAAA 2 5.5 1.0021 -1.3703 0 0 0 0 0 0 0 0 0 7.77676 0 9.76137 0 0 0 A0A8P0NQC2 A0A8P0NQC2_CANLF Chromosome 1 C6orf118 homolog C1H6orf118 Canis lupus familiaris (Dog) (Canis familiaris) DLTPRKPP;LNPNKLYRPPETILN;LRGSRSYSVL;YISSYLAGI 4 7.9 1.0028 -1.9094 3.94832 0 0 0 0 0 0 9.03793 9.69985 0 0 0 0 10.1325 0 A0A8P0NQD4 A0A8P0NQD4_CANLF Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737] thiopurine S-methyltransferase activity [GO:0008119] VLCYDPTKHAGPPFYVP 1 7.1 0.98365 -0.25675 0 0 0 0 0 0 0 0 9.78341 0 0 0 0 0 0 A0A8P0NQE1 A0A8P0NQE1_CANLF Olfactory receptor OR5B2B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;LLASMAYDRYTAV 2 8.3 0.98547 -0.25331 0 0 0 0 0 0 0 0 0 0 0 0 0 9.49189 0 A0A8P0NQE2 A0A8P0NQE2_CANLF Inner centromere protein INCENP Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819] AASARIICHSYLERLLN;EEKKKKEE;ICNVDNKDLVWLE;KKEEEQERLRKVAEAKRLAEQREQE;NVDNKDLVWLE;PVEAAEPEVSKDDRSTL;RQKVEEDKRRRLEEVKLKREERLR 7 12.7 1.0029 -1.3311 0 0 0 0 8.08863 10.2879 0 9.1636 0 5.61562 0 8.60759 0 0 0 A0A8P0NQE4 A0A8P0NQE4_CANLF Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein LOC491791 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DELFKTLTE;DNFLPEVFAQLRDET;EAPHTTRDPVAPQATGDPAVPHA;EVPCTTSDP;HIFIAPLFAATAERIHE;ISSTYVERLQGV;KENEDRVDLHKTATSGGYKITS;LRFMRRMIDLKDELY;LVIEQMICDNDPELGGAVH;PALAQPKRHR;QDTEGCRQI;VENFYETLESI;VGLVNRPDEEKDKEEETSPRKRQ 13 17.3 1.0026 -1.487 10.3347 9.31782 0 0 9.7097 0 15.6002 10.3562 15.7466 0 0 0 13.2124 13.3819 15.2039 A0A8P0NQE6 A0A8P0NQE6_CANLF Calcium homeostasis endoplasmic reticulum protein CHERP Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874]; RNA processing [GO:0006396] RNA binding [GO:0003723] FERPPYPHRF;IQQSQWNLQQQE;LQLWEKNGYFDDSIIQQ;PHNFNRFPPRFMQDDFPPRHPFER;PLDPKDIRLPP;PPLAPAAPIP 6 9.8 1.0018 -0.67596 13.7909 10.4362 10.788 6.32833 8.79698 0 0 0 0 0 0 0 7.0594 7.2538 7.58391 A0A8P0NQF0 A0A8P0NQF0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SRVCFPAGSGFLFVCL 1 8 0.95282 0.05248 0 0 0 0 0 0 0 0 0 0 0 0 0 9.45888 0 A0A8P0NQH3 A0A8P0NQH3_CANLF Glutamine rich 2 QRICH2 Canis lupus familiaris (Dog) (Canis familiaris) ETRPAALESQ;GLVQPGADQLGLVQPGADQRDLVQP;IHFGGSVKASSQMIRELLQAQC;PGAYLPDWVQPGP;SLDPKQIYTVDQ;SMSQFRKESDRRRMREPQLHSLA;STLLSMSMAP;SVQLGMDQRGL;TDQQRLELPSTGQPGM;VGPGLPGHRSIRPYTIFEL;VLRQLEMDQHGLVQPEI;VQPEMDQHSLVQPG;YHSLEKLEKEKANREHLEME 13 8.5 1.0025 -1.1326 0 6.37372 9.06245 9.57003 5.01863 0 11.7065 8.88917 0 7.37478 0 0 14.2813 10.7505 0 A0A8P0NQI3 A0A8P0NQI3_CANLF Zinc finger protein 768 ZNF768 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EGSLKGNMSENEEEEMSQQE;PDSDSQSPEFEP;YKCPRCGKAFADSSY 3 8.7 1.0033 -0.83691 0 0 11.6566 0 0 0 9.58967 0 0 0 0 0 0 0 0 A0A8P0NQK6 A0A8P0NQK6_CANLF Leucine rich repeat containing 55 LRRC55 Canis lupus familiaris (Dog) (Canis familiaris) inorganic cation transmembrane transport [GO:0098662]; metal ion transport [GO:0030001]; monoatomic cation transmembrane transport [GO:0098655] plasma membrane [GO:0005886] SAPVGSLQHCCC;YLTCYMELRVLDLR 2 8.2 0.91718 0.11137 0 0 0 6.73674 0 0 0 0 8.92496 0 0 0 0 0 0 A0A8P0NQL6 A0A8P0NQL6_CANLF "CEA cell adhesion molecule 16, tectorial membrane component" CEACAM16 Canis lupus familiaris (Dog) (Canis familiaris) EPSQVPRQTE 1 2.1 0.99985 -0.61146 0 0 0 0 0 0 0 0 0 0 6.38024 0 0 0 0 A0A8P0NQM4 A0A8P0NQM4_CANLF Collagen type III alpha 1 chain COL3A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix structural constituent [GO:0005201]; metal ion binding [GO:0046872] GAPGGKGD;GPPGGAGP;GSPGQRGEPGPQ;NGKPGEPG;PGPPGTNG;PKGNDGAP;RLPIIDIAPYDVGG 7 4.8 0.99695 -4.1083 0 0 9.9026 9.04944 0 0 9.45921 10.0279 0 0 0 10.1906 9.96578 12.2314 0 A0A8P0NQQ0 A0A8P0NQQ0_CANLF Protein-glucosylgalactosylhydroxylysine glucosidase PGGHG Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824] RVAMGSWPITV;VGWMELKDPRRAQ;VYHDTLHVSGVYNGA 3 5.5 0.99245 -0.16766 0 0 0 0 0 0 0 0 0 0 0 0 9.04418 0 0 A0A8P0NQS8 A0A8P0NQS8_CANLF Myosin IXA MYO9A Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] growth cone [GO:0030426]; membrane [GO:0016020]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microfilament motor activity [GO:0000146] AAGKSEHSSKLRKQLKK;EVLRRIILLQ;KTERKKRRKKETDLVEE;LVLEPRASD;NKAKTRLSLI;RITKSLLHLHKKKK;RKTVTVGEKL;TDSSSTQQLALFGN;YHVFYYLL 9 4.3 1.0027 -1.7752 0 9.0511 0 0 0 7.78797 8.79331 4.94458 4.49435 0 0 0 8.45208 0 7.54574 A0A8P0NQU6 A0A8P0NQU6_CANLF Xin actin binding repeat containing 1 XIRP1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] cell junction [GO:0030054] actin binding [GO:0003779] DGSSAASHSQSAAQRD;DGSSAASHSQSAAQRDGV;ELKGDVKKTVKLF;KVRNHTEA;LIPPGPDV;PASQRTPGEAQT;QEEEGKSQAGSQPEA;SLAHPPLA;SPLPTGQQKN;VGPRDHEGLISEH 10 5.8 0.99908 -3.1864 0 0 0 7.58826 7.90671 0 0 13.8398 19.9952 0 0 8.82512 12.4152 10.7921 0 A0A8P0NQU9 A0A8P0NQU9_CANLF KLF transcription factor 12 KLF12 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] GSPNVHNYPDMEAVPLLLNNV;PVSMTASASS;TGEKPYKCTWEGC;VASASGVGGQQFLHI;VPVVYTAVRSP 5 18.3 1.0028 -0.77727 0 0 0 0 0 0 0 0 9.62187 0 0 0 9.23201 0 0 A0A8P0NQW1 A0A8P0NQW1_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] RNA binding [GO:0003723] GGDRGGSV;QPSLGYGQSNYSYTQL;YTQLSPPQ 3 5.3 1.003 -2.1595 0 0 13.1027 0 0 0 0 0 0 8.5428 0 0 0 0 0 A0A8P0NQW5 A0A8P0NQW5_CANLF Opioid growth factor receptor (OGFr) conserved domain-containing protein OGFR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] opioid growth factor receptor activity [GO:0140625] GGEGPEGAEGPEGPGCAE 1 4.2 0.98044 0.048313 0 0 0 0 0 9.20087 0 0 0 0 0 0 0 0 0 A0A8P0NQX5 A0A8P0NQX5_CANLF Inter-alpha-trypsin inhibitor heavy chain 5 ITIH5 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan metabolic process [GO:0030212] serine-type endopeptidase inhibitor activity [GO:0004867] CGLTRRVLEEEDA;TRTLFPNYFNGS 2 2.9 0.90323 0.12236 6.48866 0 0 0 0 8.21791 0 0 0 0 0 0 0 0 0 A0A8P0NQZ1 A0A8P0NQZ1_CANLF Kallikrein related peptidase 10 KLK10 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] CILGNTWRA;LPRRTDEHDLMLL;YSFLLPASFP 3 6.6 1.0024 -1.3558 0 0 0 9.67923 0 0 0 0 0 0 0 0 8.91704 0 3.99919 A0A8P0NQZ5 A0A8P0NQZ5_CANLF Dematin actin binding protein DMTN Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] cytoplasm [GO:0005737] actin binding [GO:0003779] EEEEEEEDDDSGDEMK;GAEEEEEEEDDDSGDEM;GEVSLPHSGS 3 5.2 0.99027 -0.516 4.69432 0 0 0 0 0 0 0 6.09816 0 0 0 8.94518 5.14633 0 A0A8P0NQZ8 A0A8P0NQZ8_CANLF Adhesion G protein-coupled receptor F2 ADGRF2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DEAKMQSYSVMAN;EYARMSETITDMLMQK;LNAFQGFF;LSVILPKELKRISLIFEK;MQKCPKDLSCVLRNIQ;SIAFPTLG 6 11.6 1.0028 -0.89472 0 0 0 7.58323 0 0 0 14.766 7.16038 0 0 0 0 6.0515 0 A0A8P0NR03 A0A8P0NR03_CANLF TNF superfamily member 15 TNFSF15 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164] QNSHPMEVKKMLGVHL 1 4.9 0.95867 0.049233 0 0 0 0 0 0 0 7.56978 0 0 0 0 0 0 0 A0A8P0NR12 A0A8P0NR12_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AASFGPGP;AGRCARSCCCCCCC;AGRCARSCCCCCCCC;ARSCCCCCCCCCRR;CCCCCCCCCR;CQECKPSAGRCARSCCCCCCCC;ECKPSAGRCARSCCCCCCCCC;GRCARSCCCCCCCC;GRCARSCCCCCCCCC;PGVSEAASFGPG;PSAGRCARSCCCCCC;QECKPSAGRCARSCCCCCCC;RCARSCCCCCCCC;RSCCCCCCC;RSCCCCCCCC;RSCCCCCCCCC;RSCCCCCCCCCR;SAGRCARSCCCCCCCC;SCCCCCCCCCRR 19 9.3 0.8661 0.16165 0 0 0 5.65079 5.57304 7.91803 0 0 0 0 5.10299 0 0 0 6.23059 A0A8P0NR20 A0A8P0NR20_CANLF Lactate dehydrogenase C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" VISILMKDLLILFLRTP 1 6.8 0.97651 0.046227 0 0 0 0 5.91167 0 0 0 0 0 0 0 0 0 0 A0A8P0NR38 A0A8P0NR38_CANLF Transmembrane protein 71 TMEM71 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CSLMITIAFIISR 1 4.5 0.94002 0.059849 0 0 0 0 0 0 0 0 0 9.16892 0 0 0 0 0 A0A8P0NR51 A0A8P0NR51_CANLF PEAK family member 3 PEAK3 Canis lupus familiaris (Dog) (Canis familiaris) VSLAGPRR;VSLAGPRRQ 2 1.5 0.99646 -0.57676 0 0 0 0 0 0 0 0 13.2682 0 0 0 0 0 0 A0A8P0NR56 A0A8P0NR56_CANLF 26S proteasome non-ATPase regulatory subunit 5 LOC610717 Canis lupus familiaris (Dog) (Canis familiaris) proteasome assembly [GO:0043248] AISSIFYIPP;IGGDNLSVAKALIV;STELKIRCL;TELKIRCL 4 7.3 0.98992 0.020486 14.8707 13.9512 14.9243 12.9512 12.9167 13.4951 15.2105 14.3864 15.3749 12.5729 12.2066 11.9833 15.1392 15.2207 15.2213 A0A8P0NR64 A0A8P0NR64_CANLF GRAM domain containing 2A GRAMD2A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SPPLCPRWHYS;VYDMLRRVCTHLQPS 2 6.5 0.98454 0.035491 0 0 0 0 0 0 0 0 9.27782 0 0 0 0 0 0 A0A8P0NR76 A0A8P0NR76_CANLF Methyl-CpG binding domain protein 2 MBD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677] GDGGGGGG;GGDGGGGG;GGGGGGGA;GGGGGGGG;IVTDEDIRKQE 5 6.8 0.98846 -0.22731 0 0 0 0 0 0 0 0 9.14006 0 0 0 0 0 0 A0A8P0NR79 A0A8P0NR79_CANLF 6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) BCO2 Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrobiopterin biosynthetic process [GO:0006729] 6-pyruvoyltetrahydropterin synthase activity [GO:0003874]; metal ion binding [GO:0046872] GGGGGGGG;SYFLSTEAHFP 2 13.2 0.98865 -0.26069 9.24667 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NR96 A0A8P0NR96_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" SLC25A5 Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743] ATP:ADP antiporter activity [GO:0005471] AGGVAAAI;KRTQFWRYFAGN;VLSFWRGNLANV 3 11 1.0021 -1.305 0 0 10.5787 0 0 0 0 0 0 8.24484 0 17.7001 0 0 0 A0A8P0NR97 A0A8P0NR97_CANLF Leukotriene B4 receptor LTB4R Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] leukotriene receptor activity [GO:0004974] LDRSLAVALPF 1 3.3 0.99589 -0.099922 0 0 0 0 0 0 0 0 6.73971 0 0 0 0 10.0305 0 A0A8P0NRG5 A0A8P0NRG5_CANLF Orthopedia homeobox OTP Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DGAAGGPR;DITTVGSTPASL;IFMREELA;MGDSLCSFHANDTRWAAA 4 11.7 1.0029 -1.8893 4.09685 0 0 0 0 0 0 0 0 0 12.1655 0 0 0 0 A0A8P0NRH2 A0A8P0NRH2_CANLF Adenosine deaminase RNA specific B2 (inactive) ADARB2 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] ADFPDTLFKQFE;EVIDGTTGKRSCGG;NTEDEDNLSTSSADV 3 5.9 0.99338 -0.062156 0 4.96864 0 0 0 12.5838 0 13.2162 0 13.4756 0 13.3911 0 0 6.44241 A0A8P0NRI1 A0A8P0NRI1_CANLF Cadherin domain-containing protein LOC487173 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EIIVAVFSVSDADSGQ;GVWAHNGEVRTARL;KVLDVNDNTPQL;QTKVHRKKRQVAILIIW;VAVDGDAG 5 8.2 1.0026 -1.0044 0 0 0 0 0 0 9.51049 0 6.26808 10.4397 10.3818 0 0 7.85175 0 A0A8P0NRI4 A0A8P0NRI4_CANLF SCO-spondin SSPO Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] AACPCTQSSLLWG;ACGCDSGGDCECLCSA;AGAADSTW;CDNQDDCGDGSDEEGCAT;CGDGSDEEGCATPGCGEGQMSCS;CGHNCGEP;CREPWAQTESCNVGPCPGESCKARD;CVYDACGCDSGGDC;CVYDACGCDSGGDCE;CVYDACGCDSGGDCECLC;DACGCDSGGDCEC;DACGCDSGGDCECLC;DACGCDSGGDCECLCS;DCGDGSDEEGCATPGCGEGQMSC;DCQDGSDEDGCVDCR;DDCGDGSDEEGCATPGCGE;DGEEDCADGSDEHGC;DGSDEEGCATPGCGEGQMSCSSGH;DQPPPQGLGD;ESVQTRTT;FSCMAQPCPPPAHCA;GANCVQEPCQLGCG;GAPCEGNS;GCDSGGDC;GMGDSCCYC;GRLYRECQP;GVECTSFCAPGCTCP;GVLCDGMKDCEDGSDEEGCGP;HYEWCVYDACGCDS;LCDGEPHCPDGSDEGP;LEPTAELAAHSWHLSPLCPE;LVGEELKQ;MGDSCCYCAQPGEN;NGQPEDDF;PHRWLCDNQDDCG;PSCGCPPGQ;QEDLVPCTSLYHY;QHIHVGWRKPGFCERLCP;QLVCDGQPD;QNNCGNCTCQDSQWLCGSDSTR;RPDCQDGSDEDGCVDC;RWLCDNQDDCGDGSDEEGCAT;SGLCGDFDGDA;SVQTRTTPSPTQPEATSPGP;TEPCAGCEQQGRVRGVGE;VEGMGDSCCYCAQPG;VLVEGMGDSCCYCAQ;WLCDNQDDCGDGSDEEGCATPG;YEWCVYDACGCD;YEWCVYDACGCDSGGDCE 50 8.4 0.99674 -10.113 10.2808 12.4961 9.5254 9.11447 4.28103 9.32686 10.8211 8.38172 11.7533 10.9372 13.7942 10.6826 8.24012 12.7978 9.81264 A0A8P0NRI9 A0A8P0NRI9_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DLQLWLTAWDSGNP;GKPSLSTDA;VIVLLALRLRRWHASRLL;YSAYIPENNPRGA 4 5.9 1.0017 -0.99614 8.60403 0 0 0 0 0 0 0 0 8.37842 0 8.96052 0 0 0 A0A8P0NRK0 A0A8P0NRK0_CANLF Serotransferrin (Beta-1 metal-binding globulin) (Siderophilin) LOC477072 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] extracellular space [GO:0005615] ferric iron binding [GO:0008199] AKDLKEEDF;DCSGKFCLFHSATKDLL;DKASCVSKMLLDQQLLFGRNG;DLLFKDSAEGF;FKDSAEGF;FVKHSTVL;GQCGLVPV;KTISWNNLQGRKSCHTAVDRTAGWN;LFKDSAEGF;LNPYNLKPVVAEF;LYWKLPEPRESLQKAASSF;NDCSGKFCLFHSATKDLL;NVPGKECVPNNHER;SLQKAASSF;TVLENLPNKADLDQYEL;VFEAGLNPYNLKPVVAEF;VVKKSSTFNL;YGKDKQTRYYAVA;YWKLPEPRESLQKAASSFFTA 19 27.6 1.0042 -1.0825 0 9.60067 11.5394 0 8.92178 0 10.2965 10.2771 12.5202 3.9632 0 9.70865 0 0 11.5342 A0A8P0NRL8 A0A8P0NRL8_CANLF Syntaxin 3 STX3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] EEGEQEQLTQDDD;IKELHDMFVDI 2 8.1 0.9495 0.059561 0 0 0 0 0 0 0 0 0 0 6.38175 0 0 0 0 A0A8P0NRN1 A0A8P0NRN1_CANLF CD248 molecule CD248 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] ADGQSCEDPCAHAPCEQQ;DGDDEEDEHEAWET;EEDEHEAWETFDGSWTEVP;WLPSAAPTALGEASMAGHSRRD 4 8.2 0.81776 0.20542 0 0 0 0 0 3.94925 0 10.468 5.76612 0 0 0 8.06926 0 0 A0A8P0NRQ1 A0A8P0NRQ1_CANLF Ribosomal protein L32 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] AALRLLVRPKIVKKRTKKFI;AALRLLVRPKIVKKRTKKFIW;RLLVRPKIVKKRTKKFIWHQSDRYV 3 20.7 0.88327 0.13091 6.98025 0 0 0 6.36637 0 0 0 0 0 0 0 5.49713 0 0 A0A8P0NRR2 A0A8P0NRR2_CANLF RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (Raf-1) RAF1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] DSSYYWEIE;SKLYKNCPKAMKRLVAD 2 4 1.0034 -1.0632 0 0 0 0 0 0 0 0 4.08933 0 0 0 0 0 8.42618 A0A8P0NRS6 A0A8P0NRS6_CANLF Immunoglobulin subtype domain-containing protein CD300LF Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] THVPSRSQQEHME;VLIPTILAVLLLLLVA 2 10 0.92453 0.10879 0 0 0 0 5.19617 0 0 0 0 0 0 0 0 6.62902 0 A0A8P0NRU7 A0A8P0NRU7_CANLF Ankyrin repeat domain 44 ANKRD44 Canis lupus familiaris (Dog) (Canis familiaris) AAYMGHLD;AIFSGDPEEI;AVAYGHIDAVSL;EVLLEQKCFRQFIGNP;HEECVQMLLEQEVSI;VGSEEGYNENDSDSE 6 7.2 1.002 -1.2652 0 0 0 8.17318 8.09038 0 0 0 0 11.3335 0 0 0 12.5773 0 A0A8P0NRV4 A0A8P0NRV4_CANLF Ubiquilin like UBQLNL Canis lupus familiaris (Dog) (Canis familiaris) EHPDMQQLMQQS;LANPKASQAILQIEQ;LETLPGGD;VSGPEYIAQMLQNPSIQ 4 9.3 0.95381 0.050618 0 9.5938 0 0 10.295 0 0 0 0 0 0 2.90795 0 8.45898 0 A0A8P0NRV6 A0A8P0NRV6_CANLF FERM domain containing 7 FRMD7 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] LVLCKDTLEF 1 1.7 0.99892 -0.61146 0 0 0 0 6.80838 6.98185 0 0 0 0 0 0 0 0 0 A0A8P0NRW8 A0A8P0NRW8_CANLF "Large ribosomal subunit protein uL30m (39S ribosomal protein L30, mitochondrial)" MRPL30 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] AKLKVVKHLIRIKPLKLPQ;KLKVVKHLIRIKPLK;KLKVVKHLIRIKPLKLP;TKRRPYWEKDII 4 19.3 0.81596 0.19995 0 0 0 0 0 6.42977 0 4.30034 4.67243 0 5.47463 0 0 0 0 A0A8P0NRX1 A0A8P0NRX1_CANLF Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) GPD2 Canis lupus familiaris (Dog) (Canis familiaris) glycerol-3-phosphate metabolic process [GO:0006072] glycerol-3-phosphate dehydrogenase (FAD) complex [GO:0009331]; membrane [GO:0016020]; mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] DDFSSGTSSRS;GATGCGCA;QGRHFILEKKKKRKL 3 4.5 1.0048 -1.0505 7.22091 0 0 0 0 0 0 0 0 0 0 0 0 0 8.15583 A0A8P0NRZ3 A0A8P0NRZ3_CANLF ORAI calcium release-activated calcium modulator 3 ORAI3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGGGAHGP 1 2.7 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.15714 A0A8P0NRZ7 A0A8P0NRZ7_CANLF Histidine rich carboxyl terminus 1 HRCT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALPSTARLVGLVIGAAVAVLLLLLL;GAAVAVLLLLLL;RLVGLVIGAAVAVLLLLLLA 3 21 0.86962 0.13418 0 0 0 0 0 5.07921 0 0 0 0 0 6.91421 0 7.70349 0 A0A8P0NRZ8 A0A8P0NRZ8_CANLF Coiled-coil domain containing 110 CCDC110 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] DLSPSHKE;GPHSCGPTQ;YNVLVGQN 3 3 1.0032 -2.4102 0 0 0 0 0 0 0 0 11.4652 0 0 0 0 0 0 A0A8P0NS06 A0A8P0NS06_CANLF Ferritin Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] LDEEQSPEVFQH;PFYQPTATLQPFFQSQ;TEQTQGLPFYQPTATLQPFFQSQPS 3 13.7 0.86849 0.13521 10.4677 0 0 0 9.34736 0 0 0 9.03724 0 0 0 0 0 0 A0A8P0NS19 A0A8P0NS19_CANLF Neurocalcin-delta NCALD Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EQKLKWAFSMYDLDGN 1 8.8 0.96223 0.049233 0 0 8.73748 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NS31 A0A8P0NS31_CANLF Ciliogenesis-associated TTC17-interacting protein CATIP Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886] AAPEANAEAIHFLSNLQ 1 4.4 0.99398 -0.18871 0 0 0 0 0 0 10.0247 0 0 0 0 0 0 0 0 A0A8P0NS32 A0A8P0NS32_CANLF Neuromedin U receptor 1 NMUR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuromedin U receptor activity [GO:0001607] GSQDRGRTQVTKMLCKCCYREERR;ITTLFFFCLPMAT 2 10.7 0.99295 -0.27126 0 0 0 0 0 0 0 0 0 0 0 0 0 7.94152 0 A0A8P0NS50 A0A8P0NS50_CANLF 40S ribosomal protein S4 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GPKKHLKR 1 3 0.99007 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 9.15188 0 0 A0A8P0NS62 A0A8P0NS62_CANLF Serpin family E member 3 SERPINE3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] HAACPYLPLLGLSNSVFTFL;PILNSWGVTDLFDP 2 8.6 0.98509 -0.24692 0 0 0 0 0 0 0 0 0 0 8.35852 0 0 0 0 A0A8P0NS99 A0A8P0NS99_CANLF Scavenger receptor class F member 2 SCARF2 Canis lupus familiaris (Dog) (Canis familiaris) scavenger receptor activity [GO:0005044] AQACSCHEDSC;CDGNSTCS;GEAGCAAG;PPSGLEQP;RCERYCQCFRGRCHPVDGTCACE;RCPPCRDGHACNHVT;VAVCDGNSTCSENEV 7 8.8 0.9893 -0.26592 0 3.87823 0 0 10.7895 11.1166 0 0 0 0 0 0 0 0 0 A0A8P0NSA9 A0A8P0NSA9_CANLF LLLL and CFNLAS motif containing 1 LLCFC1 Canis lupus familiaris (Dog) (Canis familiaris) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] AAILLLLRVKVV;FLAAILLLLRVKVVKP;LLLLRVKVVKPQKGSL;VFCFNLASIMVFL 4 22.8 0.9923 -0.032844 0 4.27843 0 3.42048 0 0 5.55348 0 0 0 0 0 0 11.4389 0 A0A8P0NSB2 A0A8P0NSB2_CANLF Kelch like family member 11 KLHL11 Canis lupus familiaris (Dog) (Canis familiaris) ETSRARTRTRTRTCTH;KGKETSRARTRTRTRTCTHNPPKL 2 2.9 0.99214 -0.54372 0 0 0 12.7256 0 0 0 0 0 7.20887 0 0 0 0 0 A0A8P0NSB6 A0A8P0NSB6_CANLF "Nuclear protein, coactivator of histone transcription" NPAT Canis lupus familiaris (Dog) (Canis familiaris) AEIKRQRRLAAQ;DLPACSPA;DVTVIAPEG;FLTSDNNIA;KKKKIKKKKLP;MKKKKIKKK;MKKKKIKKKKL;PVNRLPDSSDLPV;SAPVSAQPPLPQLQTPPRSN;SGNTSKTNQFCESSNN;TPKLKPTEK;TTTTTTTPSTATQ;YQNEDPSN 13 8.9 0.9999 -2.8225 0 9.55209 11.3138 0 3.10762 10.3756 5.53123 0 0 10.1839 12.2424 0 0 0 10.7471 A0A8P0NSC5 A0A8P0NSC5_CANLF C2H2-type domain-containing protein LOC111091403 Canis lupus familiaris (Dog) (Canis familiaris) EHVRMHPGD;ITHTGEKPYKCKE 2 3.7 1.004 -1.0752 0 0 0 0 0 0 0 0 0 7.28281 0 0 0 0 0 A0A8P0NSD4 A0A8P0NSD4_CANLF Calponin CNN3 Canis lupus familiaris (Dog) (Canis familiaris) actomyosin structure organization [GO:0031032] actin binding [GO:0003779]; calmodulin binding [GO:0005516] DQTTISLQMGTNKGAS;EGSSSWPKASAVPAAA 2 8.6 0.98247 -0.25112 0 0 0 0 0 0 0 0 0 0 0 0 10.7751 0 0 A0A8P0NSD7 A0A8P0NSD7_CANLF Interleukin 17D Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] extracellular space [GO:0005615] cytokine activity [GO:0005125] EAYCLCRGCLTGPL;LPEAYCLCRGCLTGPLGEE;LPEAYCLCRGCLTGPLGEEDPRFR 3 13.3 0.67918 0.28307 0 0 7.87578 0 11.3848 0 0 4.80095 0 0 0 0 9.27067 0 0 A0A8P0NSE6 A0A8P0NSE6_CANLF Ig-like domain-containing protein LOC484314 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PPGATLGD 1 2.9 0.99029 -0.26592 0 0 0 0 0 0 10.1213 0 0 0 0 0 0 0 0 A0A8P0NSF4 A0A8P0NSF4_CANLF exo-alpha-sialidase (EC 3.2.1.18) NEU2 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] exo-alpha-sialidase activity [GO:0004308] FLMFTLKQAFPAEF 1 3.7 0.94551 0.08453 0 0 0 0 0 0 0 0 10.1128 0 0 0 0 0 0 A0A8P0NSH2 A0A8P0NSH2_CANLF Kelch repeat and BTB domain containing 7 KBTBD7 Canis lupus familiaris (Dog) (Canis familiaris) EEDDARSESSTEWDLDGFSEL;NFRQLSRMGSVREES 2 5.3 0.99373 -0.17231 0 0 0 0 0 0 8.14888 10.5381 0 0 0 0 0 0 0 A0A8P0NSH4 A0A8P0NSH4_CANLF A-kinase anchoring protein 8 AKAP8 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] AGGYDNSVPYG;DTLGGEKEETPEE;NHNRRLAAEQF;RIQFACSVCKFRSFEDEEIQK;SEGDFSENDDGAA 5 10 0.99188 0.0044154 0 0 11.9561 0 0 0 0 8.02614 8.9065 0 0 7.19298 0 0 0 A0A8P0NSH6 A0A8P0NSH6_CANLF Leucine rich repeat containing 9 LRRC9 Canis lupus familiaris (Dog) (Canis familiaris) EMHDSERYRKM;ILNSVMGRRNCDC;KVKRVIKVNNRILRL;LCLNYNHIESIIPRVKPQ;LNLSGNQICSFKTTAMKKIMYYNM;SFIPVTSSPM;SLNLHGNS;VGNIHFEEG 8 7.6 1.003 -0.85757 0 0 8.39412 5.05381 8.788 0 11.6331 8.24674 0 0 11.4249 8.96183 0 8.76408 8.64187 A0A8P0NSL7 A0A8P0NSL7_CANLF Rabphilin 3A RPH3A Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] membrane [GO:0016020] metal ion binding [GO:0046872] EFNEEFFYDIKHSD;GLIVGIIRCVHLA;VGGYSAPGAREDR;VGSLDSWTSEKRSP 4 7.2 0.98261 -0.25005 0 0 0 0 0 0 0 10.1904 0 0 0 0 0 0 0 A0A8P0NSL8 A0A8P0NSL8_CANLF Activating transcription factor 7 interacting protein 2 ATF7IP2 Canis lupus familiaris (Dog) (Canis familiaris) ESVSPDERQTSVSSETSDP;INENICVT;PELKVKRVLRPKGI;SVSSGVVQMPETTVNSAL 4 8.6 0.99138 -0.27623 0 4.33985 0 0 0 0 0 0 0 6.99842 0 10.0432 8.75852 0 0 A0A8P0NSM5 A0A8P0NSM5_CANLF Zinc finger protein 883-like LOC119863913 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SQLEQGRSPWMVWRDIPRDP;WDSSLILHQRTHT 2 5.3 0.99232 -0.17655 9.43538 0 0 0 0 0 0 0 10.1747 0 0 0 0 0 0 A0A8P0NSN0 A0A8P0NSN0_CANLF 2-phosphoxylose phosphatase 1 (Acid phosphatase-like protein 2) PXYLP1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] ELTQTGVVQHLQ;VGFLSWWMLKIK;VHVFIRHG 3 6.3 1.0025 -1.0035 0 0 0 0 0 0 0 0 4.74664 0 0 0 3.22603 0 7.62987 A0A8P0NSN4 A0A8P0NSN4_CANLF Ubiquitin associated protein 1 like UBAP1L Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] ESCRT I complex [GO:0000813] ubiquitin binding [GO:0043130] DDGQEEEDEDEHEDEEEDQGEEEEQ;DEEDDGQEEEDEDEHEDEEEDQG;DGQEEEDEDEHED;DGQEEEDEDEHEDEEEDQGE;EEDDGQEEEDEDEHEDEEE;FSDMGFQQ;MFQFSESQAGE;MHDFSLERKAL 8 14.6 0.99009 -0.20105 6.80129 5.8877 9.52544 5.77133 0 7.59328 9.97957 7.67044 0 0 3.84167 0 0 0 0 A0A8P0NSP7 A0A8P0NSP7_CANLF Microtubule associated protein 1 light chain 3 gamma MAP1LC3C Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] membrane [GO:0016020] EVAGIRAK;KFPNKIPVIVE 2 10.7 1.0025 -1.4058 0 0 0 0 0 0 7.95878 0 0 0 0 0 0 0 0 A0A8P0NSQ0 A0A8P0NSQ0_CANLF Leucine rich repeat protein 1 LRR1 Canis lupus familiaris (Dog) (Canis familiaris) LDTAKTCVCGRFCL;LKEPPVDIC;LSKANSSSLKSFLSA;SLEYLDLFGNTFEQPK;SYFCSLTCYVNCCD 5 16.4 0.99217 -0.040729 9.79313 0 0 0 0 0 0 11.1174 0 0 0 9.34085 0 0 0 A0A8P0NSQ3 A0A8P0NSQ3_CANLF IRG-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] FYFVRSKV;INALRGVGHDEEGAAPI;LETTLLKEL 3 8.4 0.99168 -0.27705 0 0 0 0 0 0 0 10.4023 0 0 0 0 0 0 0 A0A8P0NSR6 A0A8P0NSR6_CANLF Importin subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737] nuclear import signal receptor activity [GO:0061608] QAAEKLGETEKLSIM;TEKLSIMIEECGGLDKIEALQ;VEQIVYLVHCGI 3 8.1 0.94962 0.053965 0 0 8.20163 0 0 0 0 0 0 0 0 0 0 0 7.83099 A0A8P0NSS1 A0A8P0NSS1_CANLF Olfactory receptor LOC403898 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AICSPLLYNVIMAH 1 4.5 0.93584 0.065927 0 0 4.67452 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NSS8 A0A8P0NSS8_CANLF Secretory carrier-associated membrane protein (Secretory carrier membrane protein) LOC102152274 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] membrane [GO:0016020] DALALPLEGA;VLGIVMLKRI 2 5.7 0.99884 -0.61146 0 0 0 9.39268 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NSW8 A0A8P0NSW8_CANLF Nuclear pore complex protein Nup85 NUP85 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] DALPLLEEKE;ELLNNWYHFL;PLSTEQKALKVLRICEQRQ;WNLVTILVLQ 4 7.7 1.0026 -1.7847 0 0 7.72042 0 0 0 0 0 10.6029 0 0 0 0 7.9589 7.97373 A0A8P0NSX7 A0A8P0NSX7_CANLF "Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.1.93) (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondrial)" ABHD10 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] hydrolase activity [GO:0016787] ARPQKVVALIG;DIQLLVYTI;IFSRSVFESPQF 3 6 1.0022 -1.2669 0 0 0 8.31447 0 0 7.64868 0 0 0 7.45861 0 0 0 10.0933 A0A8P0NSX8 A0A8P0NSX8_CANLF Carboxypeptidase A5 CPA5 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] ISTTLYMASGITVDW;QETWLALRTIMEHT;VFCIGVDLNRNWKSGF;VLLDKENEEM 4 13.2 0.98534 -0.44662 0 0 8.72693 0 0 0 0 0 8.8524 0 0 0 8.77215 0 7.54736 A0A8P0NSZ8 A0A8P0NSZ8_CANLF Cyclin B1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] AKKIPKPLVKLV;DTPSPSPMETSG;KVIAKKIPKPLVKLVKEEK;LALKILDNGEW;LVPGKVIAKKIPKPLVKLVK;LVPGKVIAKKIPKPLVKLVKEEKLS;PLKKEAKTLVPGKVIAKKIPKPLV;VPGKVIAKKIPK 8 14.8 0.97385 0.041895 0 7.7412 5.32912 1.43291 4.51134 6.54203 10.4072 0 0 0 6.21558 0 0 0 0 A0A8P0NT18 A0A8P0NT18_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP10B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] IQGHSRQRSI;KLSVMTLSIGDGANDV;LARMVVYYFYK;NLDGETNLKQRRVVKGFSQ;TDKRDLEIQ;TNPYWVMER;WQWRVRDALPQSPSEATPLLS 7 7 1.0048 -0.80421 0 0 9.26043 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NT31 A0A8P0NT31_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DRLAGKPTHVNV;EDNCHPCPPHPSPSCNEP;PHILTLTL;SMLRVTAEDWK 4 14.4 1.0034 -1.6221 0 0 0 0 0 0 8.19982 0 0 0 0 12.2241 0 0 0 A0A8P0NT64 A0A8P0NT64_CANLF Dynein axonemal heavy chain 7 DNAH7 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] FLQQWYEVGPPPVFWLSGFFFTQA;GVCLSRPETAE;IEPPPFDLSKAF;LWLTSYPSPSFPV;LYRFEGISEAASK;NEQSYAEYMEHF;NLPKFLSHDLPLFEGIT;RCERFVEELESY;SKLSSLSLGQ;SPDESTFPKPTTS;STIEYAPDFRFYI;TLLVKKKV;TVSRCGMI;VIAMDSYDK;VILPYRESGTFI;YHKVNPDQV 16 4.9 1.0035 -2.2545 11.6587 8.93331 9.93867 0 7.96578 0 4.45733 0 3.8985 0 11.3667 0 12.6977 0 10.5982 A0A8P0NT77 A0A8P0NT77_CANLF Sodium voltage-gated channel beta subunit 2 SCN2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MLYVSLKYICAFFFL;VGASVGGF 2 8.9 0.95261 0.053902 0 0 0 0 0 0 0 0 0 0 0 0 0 9.12565 0 A0A8P0NT82 A0A8P0NT82_CANLF Olfactory receptor OR10J4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VISHFFCDIRPLM 1 4.2 0.93477 0.093635 9.2923 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NT83 A0A8P0NT83_CANLF Uncharacterized protein LOC102153191 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILSVLLSAFGCSAVCCGTT 1 9 0.9505 0.049553 0 0 0 0 0 0 0 0 0 0 0 0 6.94052 0 0 A0A8P0NTB0 A0A8P0NTB0_CANLF Olfactory receptor OR5B3B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DSRLHTPMYFFLS;VLSCSDRHVSELALVYATTFN 2 10.9 0.98528 -0.24061 0 0 0 0 0 9.42813 0 0 0 0 0 0 0 0 0 A0A8P0NTD6 A0A8P0NTD6_CANLF Immunoglobulin like and fibronectin type III domain containing 1 IGFN1 Canis lupus familiaris (Dog) (Canis familiaris) ADKAGGSRAPGFLDGQGG;AGGRGASH;DAVFARDP;EVEAGTAKRRGAE;GCECCMSCA;GEAGYKDGLRGPGRMESGGEAG;GKYAFVAGS;GSGGEAVY;GVKLGSQDGVTFEEEGL;LEGPGRMGMGGEAGY;LSSWSQRETEVEAG;PGHEYHFRVVAKNELGASLPSD;PPSAPAIQAASSQGI;SNSSKYQISSAPGSKEHVL;SPSLGALGAGEALGDP;SPVGPGGP;THRLVVKG 17 5.8 0.99687 -5.1206 11.8683 5.35896 0 9.459 9.45146 10.2323 10.7715 0 10.9704 6.49847 6.02735 9.52021 0 8.74211 0 A0A8P0NTE7 A0A8P0NTE7_CANLF Actin binding LIM protein family member 2 ABLIM2 Canis lupus familiaris (Dog) (Canis familiaris) PATMHRPRLKVP;WHPACRQAARTEDKNKMH 2 4.5 0.93191 0.098753 0 0 0 8.10601 0 0 0 0 8.64104 0 0 0 0 0 0 A0A8P0NTH3 A0A8P0NTH3_CANLF M-phase specific PLK1 interacting protein MPLKIP Canis lupus familiaris (Dog) (Canis familiaris) GAPGGGGP;VGGWGSGS 2 11.5 1.0031 -1.1044 0 0 0 0 0 0 9.20337 0 0 0 0 0 0 0 0 A0A8P0NTI5 A0A8P0NTI5_CANLF TBC1 domain family member 8B TBC1D8B Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; GTPase activator activity [GO:0005096] EVLLKNALKLWLMERSN;LEETTKQN;LYVLFKKELF;NVSGEKGNYIRVD;VLKYHDPS 5 5.1 1.0035 -1.0708 0 0 0 0 0 8.11572 0 0 10.2915 0 7.44964 0 0 0 10.0847 A0A8P0NTK3 A0A8P0NTK3_CANLF Zinc finger and BTB domain containing 5 ZBTB5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ASHLHLNSVVKA;KSEPLSSPEPQDEVSDVT;LTTRTLPMSPPSERV;PVVTSVRSS 4 7.5 1.0026 -0.79314 0 0 0 0 7.94111 8.74625 0 11.0734 0 0 0 0 0 0 0 A0A8P0NTM4 A0A8P0NTM4_CANLF Immunoglobulin superfamily member 6 IGSF6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RIVLGLEINLILFYVGA 1 8.2 0.98117 0.046227 0 0 0 0 0 8.24631 0 0 0 0 0 0 0 0 0 A0A8P0NTN7 A0A8P0NTN7_CANLF Chromosome 12 C6orf132 homolog C12H6orf132 Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGD;GGGGGGGG;GGGGGGGSL;GSLRDHSSQPQ;KAPGGGGG;LPEKEVPPS;PGGGGGGG;PVDWRDPSQME;QELTEPLQIE 9 5.6 1.0033 -2.4491 9.02603 16.5375 2.66698 0 0 0 0 8.65628 0 0 7.11353 9.49203 0 10.8161 9.59162 A0A8P0NTQ7 A0A8P0NTQ7_CANLF Ecdysoneless cell cycle regulator ECD Canis lupus familiaris (Dog) (Canis familiaris) AIMEDTVEYHL;EDNDGEFLLIEAAD 2 4.2 0.99261 -0.19163 0 0 0 12.338 0 0 0 0 0 0 0 0 0 6.87603 0 A0A8P0NTR0 A0A8P0NTR0_CANLF Cytoplasmic linker associated protein 2 CLASP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of supramolecular fiber organization [GO:1902904]; regulation of microtubule polymerization or depolymerization [GO:0031110] Golgi apparatus [GO:0005794]; kinetochore [GO:0000776] microtubule binding [GO:0008017] LKKMGADLLGSV;LLDGALKLSAKDLRSQVVREACIT;RRRSFEFL;RSQSANTIGAGSRSGSP;SPEQCIKVLCPII;VEEAVADALLLGDIR;VIGDELKPHLS 7 6.5 1.0027 -1.1944 11.0995 0 0 0 0 8.66622 0 7.72948 10.4899 0 0 0 0 0 0 A0A8P0NTS0 A0A8P0NTS0_CANLF Nebulette NEBL Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] PELKRAKENQKNISNLQY;SVKYTQDHKQMKG 2 3.3 0.98963 -0.21784 0 0 0 7.81666 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NTS1 A0A8P0NTS1_CANLF Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK Canis lupus familiaris (Dog) (Canis familiaris) anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CASKDHLWNNVRRGAR;ECVGQLSCIAFPPKEEKYL;ETLNTMKEELLDD;SFPIFFFKVPKLGSE;VLLHRKPKL 5 8.2 0.95248 0.049538 0 0 0 0 0 0 0 0 0 0 0 0 5.85582 0 0 A0A8P0NTT6 A0A8P0NTT6_CANLF medium-chain acyl-CoA ligase (EC 6.2.1.2) LOC479822 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] acid-thiol ligase activity [GO:0016878]; CoA-ligase activity [GO:0016405]; nucleotide binding [GO:0000166] LDQLTKELQQH;LEPWAVGACSFIHLLPKF;LVDTIASDCPSL;NFSQLSELSQQ 4 9.2 0.99403 -0.17253 0 0 0 0 0 0 0 0 0 0 0 0 10.4486 0 9.37936 A0A8P0NTT9 A0A8P0NTT9_CANLF PPARG related coactivator 1 PPRC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712] AAIESGHKLRQADEQPFDLCFGGR;AWARAWAAALEKPSSGNLES;ESISSLSELVRAMHPYCLPNL;GNSGSSCSSSGRSRRCSSSSSSS;GSVSGGEQVLLH;IPDSELLVSPREGSSL;LSEYRRRRQQRQ;LVSGTPGTYAVPPTCN;RRRQQRQAE;SEAKKECPPPAPADSLAVGNSG 10 11.8 0.9931 -0.28623 0 0 0 0 0 0 0 0 0 0 0 0 0 10.236 0 A0A8P0NTV9 A0A8P0NTV9_CANLF Ataxin 7 ATXN7 Canis lupus familiaris (Dog) (Canis familiaris) ARQQQQQQQQPPSQPQ;ESSGNSTNCHNASSSTS;GPGAASTS;GRGYYVFDSRWNRLRCA;HQRISCAYLCAGISAALQ;PIDPPPVHESPHPP;PLDRLIGKKR 7 10.6 1.0029 -2.1112 7.68159 0 6.30001 0 8.74497 8.45726 7.99515 0 0 0 4.77284 0 0 8.82394 7.2078 A0A8P0NTY0 A0A8P0NTY0_CANLF Armadillo repeat containing 3 ARMC3 Canis lupus familiaris (Dog) (Canis familiaris) AQLAPEEEVLIHE;EADGIDPLINILSSNRDG;FQCRAMLQELNAIPSI;HASWAVMVCANDE;NEVKLMNESRKGLI;SSSSSLRRVSKEKTNTRSGSP 6 11.5 0.99128 -0.27609 8.40395 0 0 6.43023 0 0 9.14626 0 0 0 7.46956 0 0 8.37295 0 A0A8P0NTY2 A0A8P0NTY2_CANLF SH3 domain-containing protein AHI1 Canis lupus familiaris (Dog) (Canis familiaris) CERHHETNSVD;DLIQERKKLKK;EEMAKEIKKKIRKK;IHVIDENTGQYV;KKIKKKKKVPISSKA;LDFLSMEEIRNNS;LPEWEEQIIFNENFPYLLRD;PISYLEVH;SEKKIKKKKKV;SEKKIKKKKKVP;SEKKIKKKKKVPISSKAE;SKKKKKKA;VILFFEILDFLSMEEIRNNS;VTSDSHQDGKISSM 14 12 1.0022 -2.6195 0 9.26496 7.51767 0 4.02768 9.39015 0 10.1977 6.44175 9.20288 4.28081 11.4884 10.5465 0 3.39397 A0A8P0NTY3 A0A8P0NTY3_CANLF Family with sequence similarity 184 member A FAM184A Canis lupus familiaris (Dog) (Canis familiaris) AARERLQQQASDLV;DHIKMKQQALTEFEAYKHRVEDM;EAYKHRVEDMQLCAEAQ;HVLAFQTMEEEKEK;IDLLRHSHHQ;ILELEKELEEQYKK;LENHLQQKH 7 8.7 1.0018 -0.96007 0 0 0 0 0 0 11.0695 9.73157 7.79201 0 0 8.87061 7.95041 7.89002 0 A0A8P0NTZ3 A0A8P0NTZ3_CANLF Leucine zipper protein 2 LUZP2 Canis lupus familiaris (Dog) (Canis familiaris) LEKQLKEVF;QRQREQMK;TTREENPSTTECNSQKLLQ 3 10.1 1.0024 -1.3674 0 8.69429 0 0 0 0 0 0 6.77004 0 3.73639 0 0 0 0 A0A8P0NU05 A0A8P0NU05_CANLF Transcription factor 7 TCF7 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DNA binding [GO:0003677] MKEMRAKVI;QSTQVQQQQSQR 2 4.3 1.0016 -0.75377 0 0 8.4957 0 0 0 0 0 0 0 0 0 12.1782 0 0 A0A8P0NU21 A0A8P0NU21_CANLF "Propionyl-CoA carboxylase alpha chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" PCCA Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] AGGGGKGM;ALWTLKYVPHYSRQHLM;KLLAKKAKVNTIPGFD;PDTHAIHA;SDISIYYDPMISKLI;VHPGYGFLSE 6 10.8 1.0023 -1.2209 6.03267 12.0625 0 0 6.25701 0 12.6117 0 8.36497 8.46111 0 0 0 0 0 A0A8P0NU23 A0A8P0NU23_CANLF Sphingomyelin synthase 2 SGMS2 Canis lupus familiaris (Dog) (Canis familiaris) sphingolipid metabolic process [GO:0006665] membrane [GO:0016020] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" EEHMENQTNDPANTYTRPAE;EYSPRHFWWYHLIC;GLSITGSHILCGD;IIETAKLEE;LVFPYFDILFV;RRFFFIIGTLYLYRCITMYV;VGLWITQWLFLRYKSIVGRRFFFII 7 24.2 1.0028 -0.86371 0 8.97476 0 0 0 0 0 0 0 4.95019 9.2968 9.726 9.2341 0 0 A0A8P0NU27 A0A8P0NU27_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) EIF2AK4 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077] ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694] CLDDKERWSPQQLLKHSFIN;DLEEIIGLLKKLGIKLQVLINL;DVVHKVLNASNVLVDAEGNV;EAVHYLYIQ;EEDDDDDEHE;HCGEQREILHEIQRRKEEIKEERKR;LKDLEEIIGLLKKLGIKLQVLINLG;LSRLHHENIVR;RPGSSSEEDDDDDEHEGV;SLCSSEDSS;TYVALVSD 11 9.1 1.0032 -2.2082 0 9.89461 0 0 0 0 6.66149 0 11.0837 5.8252 8.23381 8.69992 9.56411 0 6.81198 A0A8P0NU29 A0A8P0NU29_CANLF Lemur tyrosine kinase 2 LMTK2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ADEEDENSDDSDEDLR;DAAPTDVSKQTPAS;DEDFFQSS;DEHGRGPADEA;DTGGVFKDNTLNTSPQSSPEVQ;DVTVYLFDQVEA;FDLMELNGVQ;GVFKDNTLNTSPQ;LDLEVKFAENKPGFTLLQ;LDYPPALLTTEMDN;LLLLLLLL;LVNDVFANKVSIG;NLEFEESSTDEDFFQSST;VDVHEALLGSLSSHTPQ;VIVISDAADGHRGT;VLVTDPPLPEPVI 16 12.5 1.0007 -2.7923 0 0 0 4.62328 8.80842 9.13999 6.17485 0 11.0612 0 0 7.48035 11.1864 0 8.41604 A0A8P0NU34 A0A8P0NU34_CANLF Uncharacterized protein C29H8orf89 Canis lupus familiaris (Dog) (Canis familiaris) SPVSASSH 1 2.1 1.0048 -1.1044 9.96138 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NU37 A0A8P0NU37_CANLF Ubiquinol-cytochrome c reductase core protein 1 UQCRC1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GTKNRPGNALEKEVE;QENDACMRD;VESMGAHLNAY;VGSRYETEKNN 4 9.5 1.0035 -1.0701 0 0 0 0 0 0 0 0 0 8.82149 8.98493 0 10.5248 0 10.0176 A0A8P0NU38 A0A8P0NU38_CANLF Solute carrier family 41 member SLC41A2 Canis lupus familiaris (Dog) (Canis familiaris) magnesium ion transport [GO:0015693] plasma membrane [GO:0005886] inorganic cation transmembrane transporter activity [GO:0022890]; monoatomic cation transmembrane transporter activity [GO:0008324] PIAASFGDLITLA;VGFLAAVA 2 3.9 1.0018 -1.4197 9.35817 9.38228 0 0 0 0 9.82118 0 0 0 0 0 0 0 0 A0A8P0NU49 A0A8P0NU49_CANLF "Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1" TANC1 Canis lupus familiaris (Dog) (Canis familiaris) synapse [GO:0045202] CQADNTYTCL;GACLEGMS;GAVVVGNVGFGKTAII;LLRKGAKLGNAAWAMATSK;LSAALASLRN;SSSAGVTN;YKVVPVSLSELYL 7 5 1.003 -2.5475 0 9.14417 10.0172 9.02137 0 0 8.01642 9.62395 0 9.46277 9.76689 0 0 0 0 A0A8P0NU57 A0A8P0NU57_CANLF Erbb2 interacting protein ERBIN Canis lupus familiaris (Dog) (Canis familiaris) HSLPQASVARH;LKMTTKRSLFVRL;MRDILRQRHR;TLEELYLDANQIE 4 3.2 0.99478 -0.17325 0 0 7.9622 0 0 0 0 0 0 0 4.96708 0 0 9.1283 0 A0A8P0NU94 A0A8P0NU94_CANLF Olfactory receptor OR9S22 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HMTAVTLFFGTVFVM 1 4.7 0.9533 0.053902 0 0 0 0 0 0 0 0 8.95542 0 0 0 0 0 0 A0A8P0NUA0 A0A8P0NUA0_CANLF Uracil phosphoribosyltransferase homolog UPRT Canis lupus familiaris (Dog) (Canis familiaris) NGGSGNCD;NSSSKAKPT;PYKECMVTTPTGE;VLLMYPILSTGNTVIEAVK 4 17.3 1.0028 -1.1448 0 0 0 0 0 0 0 0 6.91839 0 0 0 0 0 11.8189 A0A8P0NUB0 A0A8P0NUB0_CANLF Meprin A subunit (EC 3.4.24.-) (Endopeptidase-2) MEP1B Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] RDDYVRIMWDRIQSGRE;TNFKCENDGICIVQNGKPECRS 2 6 0.93459 0.094059 0 7.11925 0 0 5.49707 0 0 0 0 0 0 0 0 0 0 A0A8P0NUB4 A0A8P0NUB4_CANLF Immunoglobulin superfamily member 22 IGSF22 Canis lupus familiaris (Dog) (Canis familiaris) AEGDPPSG;ATWFTAADHVFSNKYT;EAGVGEPVELDE;GEPVELDEGVRAMPPPA;IVERRKKGSSLWVPVNKDPIQ;MGPEHEGKYTFR;SSSTTHVQTFSQTTKIVGEE;TLTWNHSPDVQED;VGDKRMTAELTVLDEPLKFL 9 10.9 1.0045 -2.017 0 11.0247 7.7412 0 0 0 0 0 0 6.91791 7.45574 6.90171 11.9731 10.7101 0 A0A8P0NUC3 A0A8P0NUC3_CANLF Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) SLC25A30 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] NWLRLGPWNIIFFVTYEQ 1 6.6 0.98529 -0.24076 0 0 0 0 7.81141 0 0 0 0 0 0 0 0 0 0 A0A8P0NUF4 A0A8P0NUF4_CANLF Mitochondrial transcription termination factor 4 MTERF4 Canis lupus familiaris (Dog) (Canis familiaris) AEEFEVFKKLFAR;DEEEEEEEDEEEEEEEDEDEEEWQ 2 20.7 0.98725 -0.22822 0 0 0 0 0 0 0 0 0 0 0 0 0 6.17513 8.50323 A0A8P0NUF8 A0A8P0NUF8_CANLF DNA repair protein REV1 (EC 2.7.7.-) AFF3 REV1 Canis lupus familiaris (Dog) (Canis familiaris) error-prone translesion synthesis [GO:0042276] nucleus [GO:0005634] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] AEKNSTDFRDCIV;DEFANAVRTE;LDQATDSAKIIG;LEWQYYQNKILKGK;NLSIEVPS;RNHIIKKI;SEKPLGELSGSTSG 7 6.6 1.0031 -2.367 0 0 12.0422 0 0 0 10.5435 0 0 0 13.2296 0 0 0 0 A0A8P0NUJ3 A0A8P0NUJ3_CANLF Secretogranin-3 (Secretogranin III) SCG3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; transport vesicle membrane [GO:0030658] DYDLSKMRDFINQQ;EEAAKMEKEYGTL;GLERRTKIYNEDNFEELQ;LSKMRDFINQ;TESQAHILEDEVAEVLQ 5 13.3 0.98585 -0.42173 0 0 0 4.9296 7.8358 0 0 0 9.03546 0 0 0 0 0 0 A0A8P0NUJ7 A0A8P0NUJ7_CANLF Unc-13 homolog B UNC13B Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887] presynapse [GO:0098793] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543] ACASGSGSQDLSS;IVDEFAMRY;KRLRQKKLLHELVQK;LPLVSDLSLVQ;NLDFWPKLITL;NQSFEIIRKLECPDP;SDLSLVQSRKAGI;STVDLLTSITFF;VLREKRLRQKKLLHELVQKANHLS;VPAVMSTLLA 10 5.6 0.98743 -0.22962 0 0 0 0 4.48349 0 0 0 0 0 5.80147 0 0 0 0 A0A8P0NUK6 A0A8P0NUK6_CANLF Zinc finger protein 606 ZNF606 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECGKAFNESSSL;GEKPYNCQECGKAFRE;HTGEKLYEYKECHQI;IGTVEKAYKYNEWE;WNSHLIGHQRTHTGEKPFECTECGK;YKECHQIFN 6 10.6 1.003 -0.7897 0 0 9.96451 10.5934 9.88853 9.7006 0 0 7.56339 0 0 0 0 0 0 A0A8P0NUL4 A0A8P0NUL4_CANLF Regulator of G protein signaling 6 RGS6 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] membrane [GO:0016020] GTPase activator activity [GO:0005096] EFLAPGAPSA;EPSQQRVKRWGFSFDE;ITPAEPSNPW;SFFLSFFFFFFFFFG;SSAGFLPSTFLLGFLFVCFFHLFFF 5 14 1.0034 -1.1117 0 0 7.73836 0 7.73288 0 0 3.44903 0 0 0 0 0 9.20845 10.3252 A0A8P0NUL5 A0A8P0NUL5_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) SSH3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721] GNALTWAAHYQ;LVASRTQAFQEQ;MVELLRPQDDMR;PQLSKAKGGRRC;QALELRLGRPLQQYRDFIDNQ;RRCGKGPWPALKSRQS 6 12.6 1.0023 -0.72465 0 0 0 0 0 0 0 0 0 11.7087 0 9.53415 0 7.58007 7.12329 A0A8P0NUM3 A0A8P0NUM3_CANLF Ubinuclein 1 UBN1 Canis lupus familiaris (Dog) (Canis familiaris) CQAMLSKGLS;DEIRELLCH;DSLTDLDLEQLLSESP;EKKKKSPKKRKLKEGGEKIKKKKK;EVQTRELSSQIRSGVY;GWMQARTLFKE;IKEKKKKSPKKRKLKEGGE;LDQEFRQPSSLPE;LNASKEKKKKK;PRTSHAPQAAAPV 10 11.3 1.0046 -1.0476 5.60383 12.0314 9.22106 0 0 9.19399 0 5.73145 9.47628 10.2203 0 7.93976 5.28902 9.88984 0 A0A8P0NUM6 A0A8P0NUM6_CANLF "Trifunctional enzyme subunit beta, mitochondrial (EC 2.3.1.155) (EC 2.3.1.16) (TP-beta)" LOC481043 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] acetyl-CoA C-acyltransferase activity [GO:0003988] MMLDLNKAKTL;SANQAMIT;VGSPPLEKFN 3 6.6 1.0031 -0.83759 0 0 10.1882 0 0 0 0 0 0 10.9602 0 0 0 8.57841 0 A0A8P0NUM9 A0A8P0NUM9_CANLF Ankyrin repeat and SOCS box containing 15 ASB15 Canis lupus familiaris (Dog) (Canis familiaris) CYFMHVNDTRFP;SVLFEAAGGG;VPILATFKTSSS 3 6 0.99044 -0.53628 0 0 0 0 0 0 0 10.4588 0 0 0 0 11.3858 11.5434 0 A0A8P0NUN8 A0A8P0NUN8_CANLF RNA binding motif protein 41 RBM41 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ALYYQAYHKKTSADTY;LQTDSPRVNSCVKSGEHVLEELE;PEAIQNRLQDIEERISERQRI 3 11.8 0.99143 -0.14512 0 11.1404 7.60763 0 0 0 0 0 0 0 0 0 0 0 9.92365 A0A8P0NUP5 A0A8P0NUP5_CANLF Transcription initiation factor TFIID subunit 2 (Transcription initiation factor TFIID 150 kDa subunit) TAF2 Canis lupus familiaris (Dog) (Canis familiaris) transcription factor TFIID complex [GO:0005669] FILDLIKYNDNR;LEPGQILEKNE;PLPELGLVLNLKEKKAVL;SSQKFQSHMWSQML;WEYYTMFQCKAHLVM;YTHDMRKKTFHYM 6 6.6 0.98609 -0.41253 0 9.10224 0 0 0 0 0 0 8.011 0 0 0 0 0 6.93534 A0A8P0NUP8 A0A8P0NUP8_CANLF Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) ARHGEF2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell division [GO:0051301]; innate immune response [GO:0045087]; nervous system development [GO:0007399] bicellular tight junction [GO:0005923]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; spindle [GO:0005819] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] EEDSGGVA;ELQASGCMGCQEAPSS;HTRFLSQLLERRRQALCP;RLRESEQARALL;TWVSSPLQRTFSFFLSMT;VGPGVELL;YKELYARDKRFQQFIRKVTR 7 8.9 0.96104 0.049233 0 0 0 0 0 0 0 0 0 9.92689 0 0 0 0 0 A0A8P0NUR0 A0A8P0NUR0_CANLF Latent transforming growth factor beta binding protein 4 LTBP4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] AAGSECEDVDECEN;ASCLDVDECSEEDLCQSGIC;CCRGAGLA;DVDECATGGRCQHGECAN;ECVDNDECA;EPPPCGPG;HLCLCFSQACEEPS;LRGGECASPLPGL;PTGFLPTHRPEPPPEPRPG;SYHCTCEPPL;VYTMPLAN;YHAQRLECVDNDECADEEP 12 9.5 0.99054 -0.26186 0 0 0 0 0 0 0 0 0 0 0 0 8.9284 0 0 A0A8P0NUS9 A0A8P0NUS9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ANKLGNLEEMDAF;HHNQVGFIPGTQGWF;MDAFLESHKL;MNEKGEITTNT;TLGAFPLR 5 5.3 0.95218 0.05389 0 7.18319 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NUV5 A0A8P0NUV5_CANLF Serine hydroxymethyltransferase (EC 2.1.2.1) SHMT1 Canis lupus familiaris (Dog) (Canis familiaris) glycine biosynthetic process from serine [GO:0019264]; tetrahydrofolate interconversion [GO:0035999] glycine hydroxymethyltransferase activity [GO:0004372]; pyridoxal phosphate binding [GO:0030170] GPKAGAKP;YLMADMAHIS 2 3.5 0.99928 -0.61146 8.94647 0 0 0 0 0 0 0 0 0 2.97858 0 3.14156 0 0 A0A8P0NUV9 A0A8P0NUV9_CANLF Contactin 3 CNTN3 Canis lupus familiaris (Dog) (Canis familiaris) EVPPSEVSG;GQGVVLLCGPPPHSGELSYAW;GVTNWIQTVVTSPDT;TDTKVLLNWEQVKAK;VGSMVSLDCKPRASPKPVCSW;YYAKPHWVQLIKDVEI 6 9.9 0.98989 -0.31789 0 0 9.16015 0 0 11.5947 0 0 0 0 6.14231 0 0 0 0 A0A8P0NUX0 A0A8P0NUX0_CANLF Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) XYLT1 Canis lupus familiaris (Dog) (Canis familiaris) proteoglycan biosynthetic process [GO:0030166] Golgi membrane [GO:0000139] metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158] AKSKHCRQEIGDTYCRHKL;DLLEMTDWPWDFFIN;GGGGGGGG;LVAPLTFSNRQPIKPEEVLKLHN;QLDYYLYGNYPAGT;SGGGSPEL;WNRKLGCKCQYKH 7 10.5 0.99226 0.0044549 8.08321 0 0 0 9.3092 0 4.68077 0 0 10.1614 0 0 10.2114 11.0086 0 A0A8P0NUY3 A0A8P0NUY3_CANLF Transmembrane serine protease 5 TMPRSS5 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] LVCYEGWSSALGLRICQNL 1 5.1 0.94915 0.04956 0 0 0 0 0 0 0 8.77531 0 0 0 0 0 0 0 A0A8P0NV00 A0A8P0NV00_CANLF Decaprenyl diphosphate synthase subunit 2 PDSS2 Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299] prenyltransferase activity [GO:0004659] LLETSLLLKDGGRWYFYH 1 4.5 0.98021 0.048313 0 0 0 0 0 0 0 0 0 0 5.71759 0 0 0 0 A0A8P0NV03 A0A8P0NV03_CANLF Centrosomal protein 95 CEP95 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; spindle pole [GO:0000922] FFRELEAERF;PLHPPYHP;SFKESHLR;TLSKMWKE;VSGQTLSKMWK 5 4.9 1.0009 -2.7417 7.55497 0 0 0 0 6.01473 10.1188 0 0 0 0 0 0 0 9.75136 A0A8P0NV23 A0A8P0NV23_CANLF Tubulin/FtsZ 2-layer sandwich domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] ATIKTKRTIQFVDWCPT;DVVPKDVNAAIA;GDVVPKDVNAAIA;TVVPGGDLAKVQ;VISAEKAYHEQLSV;WLPWRRIMRRLVWILLKERVKKKKR 6 26.5 0.97445 0.035538 0 0 0 6.16179 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NV49 A0A8P0NV49_CANLF Zinc finger protein 84 LOC100686099 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FFEKSELIRHQTIHTGEKP;PEETDTWLKYYEYDKYKINSKKSQI 2 6 0.98534 -0.24563 0 0 0 0 10.112 0 0 0 0 0 0 0 0 9.97341 0 A0A8P0NV50 A0A8P0NV50_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) spindle pole [GO:0000922] calcium ion binding [GO:0005509] TDEEVDEMIK;TDEEVDEMIKE 2 13.6 0.99108 -0.13496 9.43546 0 0 11.167 0 0 0 0 0 0 0 10.5098 0 0 0 A0A8P0NV51 A0A8P0NV51_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" FVDLACHLEKAAKYD 1 11.6 0.98484 -0.24506 0 0 0 0 10.8723 0 0 0 0 0 0 0 0 0 0 A0A8P0NV76 A0A8P0NV76_CANLF SEC14 like lipid binding 4 LOC486353 Canis lupus familiaris (Dog) (Canis familiaris) GEFLEHPE;GGLTGYDYEGCP;KIVILGGNWKQE;VFLKTKTSER 4 10.3 1.0011 -0.62922 8.74527 0 0 9.16679 0 0 0 0 0 0 0 0 11.2713 0 0 A0A8P0NV95 A0A8P0NV95_CANLF "Helicase, lymphoid specific" HELLS Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787] IIYDSDWNPQSDL;MAEFQRFTPDIPTMLYHG;MDYCHFRNFN;VISDKDLELLLD 4 7.6 1.0019 -1.0017 0 0 0 10.0298 0 0 0 6.80245 0 0 0 6.53998 0 0 0 A0A8P0NVA3 A0A8P0NVA3_CANLF StAR related lipid transfer domain containing 8 STARD8 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] IAVSLSPEPEPMDLPTPCHVPSL;QVPKEIENQMRWGLS;TPPMAAMELKEF 3 5.2 0.99319 -0.17547 0 0 0 0 0 0 0 0 0 0 0 0 10.2701 10.9668 0 A0A8P0NVC4 A0A8P0NVC4_CANLF E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HACE1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; Golgi cisterna membrane [GO:0032580] ubiquitin-protein transferase activity [GO:0004842] GANPNYQDISGCTPL;HRQLVNIYFTRSFYKH;LKLPEYPSKEILKDRLLV;MCCSCQMPPGMTSPRF;VTELRMTRAIQ 5 8.8 0.9864 -0.39001 0 0 0 0 0 0 0 9.21553 10.0676 0 0 0 5.32848 0 6.38829 A0A8P0NVC5 A0A8P0NVC5_CANLF Acyl-CoA synthetase family member 3 ACSF3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] nucleotide binding [GO:0000166] ALQGKANSGKGK;EVRIVSEN;LLRPVVKKLGVP;QSITGHTLLERYGM;SENPKKEGCPYVLHA;TLQEGHSLSHRELK;VDEIPRNQMGKIN;VFKDGMYWI;VTGLVHKW 9 15.5 0.99144 -0.53981 0 12.7693 12.2014 9.50474 12.5437 0 12.4135 0 0 15.1931 0 4.32567 0 0 12.2355 A0A8P0NVD0 A0A8P0NVD0_CANLF Tyrosine-protein kinase (EC 2.7.10.2) FGR Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] PDPTQARGVSSFAHIPN;PVDSIQAEEW 2 5.7 0.99569 -0.56523 0 0 0 7.32319 0 0 0 0 0 0 10.0449 0 0 0 0 A0A8P0NVD5 A0A8P0NVD5_CANLF Aurora kinase A and ninein interacting protein AUNIP Canis lupus familiaris (Dog) (Canis familiaris) QGLEDDCM;QTSIASFFTLQPGKTNGGDQ 2 7.9 1.0047 -1.0511 6.72219 6.77689 0 4.96897 0 0 0 0 0 0 6.81429 0 0 0 0 A0A8P0NVE8 A0A8P0NVE8_CANLF "Glycerol-3-phosphate acyltransferase 1, mitochondrial (EC 2.3.1.15)" GPAM Canis lupus familiaris (Dog) (Canis familiaris) CDP-diacylglycerol biosynthetic process [GO:0016024] mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886] glycerol-3-phosphate O-acyltransferase activity [GO:0004366] DIGVFKETK;FIMEAIIACSLYA;KAASLCCL;LLSNEGTISLPCQTFYQI;NKVKKKAK;SLCCLLSNEGTISLP;TIPDILIIPVGISYDRIIE;VAEQDDQEDISPGL 8 11.2 0.99942 -3.0933 0 8.1249 9.49711 9.94231 0 0 0 8.09729 9.49143 0 0 9.29345 0 9.58886 8.61809 A0A8P0NVG9 A0A8P0NVG9_CANLF Lipoic acid synthetase LIAS Canis lupus familiaris (Dog) (Canis familiaris) "4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]" LRLPPWLKTEIPMGKNYNKL;TEIPMGKNYNKLKN 2 13.8 0.98991 -0.26348 0 0 0 0 0 0 6.71039 0 0 0 0 0 0 0 0 A0A8P0NVI7 A0A8P0NVI7_CANLF Autophagy-related protein 13 ATG13 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045] Atg1/ULK1 kinase complex [GO:1990316] CAYRINLAFMSTRQF;GSSGGSSGNTH 2 5.5 0.93819 0.089397 0 0 0 0 0 0 7.66477 0 0 6.59801 0 0 0 0 0 A0A8P0NVL5 A0A8P0NVL5_CANLF "Carboxypeptidase X, M14 family member 1" CPXM1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular region [GO:0005576] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AVFPANSDPET;EPQVARFIRLLPQKW;EQHVRIRIVKKKKIIMKKRK;EQHVRIRIVKKKKIIMKKRKKLTRP;HVRIRIVKKKKIIMKK;IIMKKRKK;IRIVKKKKIIMKKRKKL;IVKKKKIIMKKRKKLT;KKKKIIMKKRKKLTRPGPL;QHVRIRIVKKKKIIMKKRKK;RIVKKKKIIMKKRKKL;SEQHVRIRIVKKKKIIMKKRK;SEQHVRIRIVKKKKIIMKKRKKLTR;SIGKSHQGLKLYVMEMSD;VRIRIVKKKKI;VRIRIVKKKKIIMKKRKKLT 16 10.9 0.99149 -0.54799 9.0197 7.25446 5.63996 5.80521 6.48615 5.61556 9.53716 6.51425 9.95951 0 0 9.36223 7.33949 8.91307 5.85808 A0A8P0NVP8 A0A8P0NVP8_CANLF Olfactory receptor OR5W2B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TFRLCFCGS 1 2.9 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 0 9.24641 0 0 0 A0A8P0NVQ7 A0A8P0NVQ7_CANLF "Alpha-1,4 glucan phosphorylase (EC 2.4.1.1)" PYGB Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] glycogen phosphorylase activity [GO:0008184]; pyridoxal phosphate binding [GO:0030170] GLDPRSPGSRPGPKFFE;IYAINQRHLDHVAALFPG;QENKLKFSAFLEKEYKV;SVFKDFYELEPEKFQNKTNGITPR 4 8.6 0.99164 -0.13884 0 0 8.96477 0 0 0 0 0 0 0 0 0 0 6.25304 12.463 A0A8P0NVV2 A0A8P0NVV2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AKKKKKKKKKDTTP;ENFSLLKDTKAKKKKKKKKKD;KDTKAKKKKKKKKKDT;KKKKKKKK;KKKKKKKKKDTTPPP;LETLYWASKEYILK;LLKDTKAKKKKKKKK;SLLKDTKAKKKKKKKKK;TKAKKKKK;TKAKKKKKK;TKAKKKKKKKKK 11 34.2 1.0025 -0.76242 7.40352 5.81034 7.8857 5.66786 2.19658 7.63974 0 0 8.40956 0 4.78701 0 8.80697 0 0 A0A8P0NW04 A0A8P0NW04_CANLF Integrin subunit alpha 3 ITGA3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EVSPASLQLRDL;FLSIDVTNTPS;REPQQVIHGEELGLPGLAT;RPVINILHKTLVARP;TVQARVWNSTFIEDY;VGAGLLLLGLIILLL;VGSLSDRIVLLRARPVI;WFSVDIDSDLVEELPAEIELWLV;WLVLVAVGAGLLLLGLIILLL 9 12.6 0.99052 -0.53679 0 8.85378 6.16459 9.33103 6.04144 8.11879 0 10.2242 11.3017 7.65163 5.76498 3.61141 4.925 10.574 3.00739 A0A8P0NW17 A0A8P0NW17_CANLF Capping protein regulator and myosin 1 linker 1 CARMIL1 Canis lupus familiaris (Dog) (Canis familiaris) DEPSSPKGAMRSPALDM;EQGPCGGFSQMYACVCDWLG;ETLESMAGEV;LIVFVALPPLSFY;LVSCSALRFFLV;NAIAHLDLS;PIHIEDPPFPSGRQ;VLDSLVQMIQ 8 9.2 0.99353 -0.057743 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3979 0 A0A8P0NW34 A0A8P0NW34_CANLF Interferon induced protein with tetratricopeptide repeats 3 IFIT3 Canis lupus familiaris (Dog) (Canis familiaris) response to other organism [GO:0051707] ECSELYCEEGWTRL;LVTWGNYAWVYYHLGRFADAQI;QGLKHKLNGE 3 9.4 0.98793 -0.48353 0 0 0 0 0 10.2912 11.8005 0 0 0 0 0 0 0 0 A0A8P0NW41 A0A8P0NW41_CANLF Calmegin CLGN Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] calcium ion binding [GO:0005509]; unfolded protein binding [GO:0051082] GIHKKRKIK;PEDWDESEPAQIED;PKEIEDPSDK 3 5 0.99096 -0.5147 0 0 7.37816 0 0 0 0 0 0 0 0 0 0 11.4794 0 A0A8P0NW58 A0A8P0NW58_CANLF Protein SERAC1 (Serine active site-containing protein 1) SERAC1 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid biosynthetic process [GO:0008654] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739] EDEGRYTTCWPKTWL;VIWVSHSMGGL 2 4.2 0.98388 -0.24759 0 0 0 0 0 0 0 0 0 0 7.08619 0 0 0 0 A0A8P0NW62 A0A8P0NW62_CANLF Solute carrier family 9 member C1 SLC9C1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216]; sodium:proton antiporter activity [GO:0015385] DLNYTMSNFTLLTK;FDFILTVVFIKIVRFLRILRILK;FIKIVRFLRILRILKLI;FLRILRILKLITPKLLQIID;IHKIESTEINKLIMAKKK;IKIVRFLRILRILKLIT;IVLRLLVFLLLSPLLS;IVRFLRILRILKLI;IVRFLRILRILKLITPKL;KIVRFLRILRILKLI;KIVRFLRILRILKLIT;KIVRFLRILRILKLITPKL;LDFQPVIKPLT;LELWFYFL;LFLIGCSFEILSFTSE;LTVVFIKIVRFLRILRILKLI;LVLYIMEALLK;RILRILKLITPKLLQIIDQ;SRFGHGFSWRWAFIMVWSEMKGTPN;TDEFEYVGYLVT;VVFIKIVRFLRILRILKLITP;VVFIKIVRFLRILRILKLITPKLLQ;YKAPSLIPITCYQVQGTEDFTKVMI 23 17 1.0032 -1.9511 12.6064 3.19234 10.8407 9.05126 6.54918 3.06178 8.81881 9.32515 8.25498 0 7.76633 0 9.76858 11.2056 5.90338 A0A8P0NW63 A0A8P0NW63_CANLF Solute carrier family 30 member 10 SLC30A10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic cation transmembrane transporter activity [GO:0008324] EPLLILSAGIIGLLFNIL;VTIQFEQVDLKDPVE 2 9.7 0.97312 0.048313 8.0474 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NW71 A0A8P0NW71_CANLF Ubiquilin 1 UBQLN1 Canis lupus familiaris (Dog) (Canis familiaris) LSQNPDLA;TLELARNP;TTGTTEPG 3 4.3 1.0033 -1.6145 0 8.49089 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NW90 A0A8P0NW90_CANLF UDP-glucose 6-dehydrogenase (EC 1.1.1.22) UGDH Canis lupus familiaris (Dog) (Canis familiaris) UDP-glucuronate biosynthetic process [GO:0006065] NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] EVVESCRGKNL;GFDPCECV;SINSISALCEATGADVE 3 6.7 1.0031 -1.1044 0 0 0 6.70736 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NW93 A0A8P0NW93_CANLF Major facilitator superfamily domain containing 13A MFSD13A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLVDEDLV;LSSRAVVL;RHRNFLWFVGMDL;VDGGLCGE 4 7.9 0.99894 -3.0333 0 10.2648 0 2.82128 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NW97 A0A8P0NW97_CANLF Syndecan SDC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDSFPDDELDDLYSGSG;KKDEGSYTLE;MGAGAQRWRNENFERPVDLEGS;PVDLEGSGDDDSFPDDELDDL 4 12.8 0.99288 -0.16675 0 0 0 7.92172 0 0 0 0 0 6.9521 0 0 0 0 3.78073 A0A8P0NWC7 A0A8P0NWC7_CANLF Small ribosomal subunit protein eS6 (40S ribosomal protein S6) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] KPIEMDDELKLHNFYEKRLATE 1 24.4 0.97481 0.046883 0 0 0 0 6.27467 0 0 0 0 0 0 0 0 0 0 A0A8P0NWD1 A0A8P0NWD1_CANLF E74 like ETS transcription factor 4 ELF4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DQEGRCLEETVPREE;ELDDVHNG;LQTIPLTTVLTNGPPASTTA;SIPIRKKSK;SSRVSARAAPQGKGGP;TLQTIPLTTVLTNGPP;VEGQRLVYQFK 7 12.1 1.0038 -2.0418 0 0 0 0 5.98853 0 0 3.60277 0 9.61073 0 0 11.5984 0 0 A0A8P0NWE7 A0A8P0NWE7_CANLF D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (Isoprenoid synthase domain-containing protein) CRPPA Canis lupus familiaris (Dog) (Canis familiaris) isoprenoid biosynthetic process [GO:0008299]; protein glycosylation [GO:0006486] cytosol [GO:0005829] cytidylyltransferase activity [GO:0070567] ISPSADGC 1 2.5 0.99008 -0.26592 0 0 0 0 0 0 0 0 10.3422 0 0 0 0 0 0 A0A8P0NWE9 A0A8P0NWE9_CANLF Sp4 transcription factor SP4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] TLTPSGQISWQ;VGQLLPLL 2 2.7 0.98989 -0.26592 0 0 7.5766 0 4.86641 4.05355 0 7.04166 7.58459 0 0 0 7.60755 7.2076 7.64875 A0A8P0NWF2 A0A8P0NWF2_CANLF Ankyrin repeat and SOCS box containing 6 ASB6 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] ADKHGKTALL;CAEDESHVDL;GVQIYNTE;VGSLAEKIQA 4 9.1 1.0029 -1.742 0 9.03472 4.25119 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NWF3 A0A8P0NWF3_CANLF "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4" SMARCA4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] SWI/SNF complex [GO:0016514] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; histone binding [GO:0042393]; hydrolase activity [GO:0016787] CNHPYMFQHIEESFSEHL;DLQAQDRAHRIGQQNE;DVSEVDARHIIENAKQ;EETILIIRRLHKV;EKKKKKKKKKAENAEGQT;EQDEEEDEV;ESESRSVKVKIKLGRKEKAQDRLKG;EYLNSILQHAKD;FNEPGSEYF;IGPDGEPLDETSQM;IVPLSTLSNWAYE;KKKKKKKK;KYLRLDGT;LIIRRLHKVLRPFLLRRLKKEVEAQ;LKALRLLNFQRQLRQ;PQLRSGKFNVLLTT;PVEILQEREYRLQARIAH;SPVMPPQTQSPGQPAQ;TILIIRRLHKVLRPFL;VLRPFLLRRLKK;YEVAPRSDSEESGSEEEEEEEEEE;YRKLIDQKKDKRL 22 17.8 1.0024 -1.124 8.58286 0 6.12199 5.63366 7.67694 0 9.64232 6.36983 8.8554 8.4025 4.8514 11.0144 6.73064 10.4707 0 A0A8P0NWG9 A0A8P0NWG9_CANLF Growth regulating estrogen receptor binding 1 GREB1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCTTDGFCQAGK;CMPQVGLVGPAPV;DHLLVCAVDRRFLPDDNG;DLELFKKLPFDY;ELGLAAYF;ESTLHAFAFSYSMLGE;GVDLYPENKKYFGLSEF;KWSSKTGSSEV;NTYHHCEQCHQYMGFHPRYQLYEST;SQLYLEAEQQLSALE;TQNVQYNQNRFMCDD;VIVRACRSPAI 12 8.9 1.004 -1.99 0 0 8.71063 0 10.6949 0 10.5177 11.6674 0 8.1984 10.2802 2.06984 6.39905 7.80697 11.9779 A0A8P0NWI3 A0A8P0NWI3_CANLF ATP binding cassette subfamily C member 6 ABCC6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] GAVGSGKS;GFQSLYVASICQL;LDEATAAVDPGTELQ;VLSCLVDQPPFFP;VSVERMKDYVQTPKE 5 4.4 1.0023 -1.201 0 0 0 0 0 0 0 0 0 6.1969 0 9.44439 8.55002 0 9.07818 A0A8P0NWJ0 A0A8P0NWJ0_CANLF PHD finger protein 3 PHF3 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] metal ion binding [GO:0046872] DSKIQSCNSGVKSVKNQ;ETSVMGSS;NRFMVGCGRCDDWFH;SLSDAVACTNPDKTEKNL;TQDKDRDRKSREEG;VGGRISPQTV 6 4.2 1.0022 -1.4249 0 0 2.90593 0 0 0 11.2173 8.8699 10.4662 0 0 8.12024 0 0 0 A0A8P0NWK6 A0A8P0NWK6_CANLF FGGY carbohydrate kinase domain containing FGGY Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] "kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" EDIWAACCVVTKKVV;MFGTRLIIEAMEA 2 5.2 0.98924 -0.26557 0 0 0 0 5.98561 0 0 0 0 0 0 0 0 0 0 A0A8P0NWL5 A0A8P0NWL5_CANLF Layilin LAYN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EATPDDMSCDYDNMAVNPSES;FKGNNEAALNL;GEATPDDMSCD;TDGSTSAFRNWYVDEPSCGS;WYTFGSTKIAWLLF 5 17.8 0.9884 -0.47298 0 0 9.87963 0 0 0 0 0 0 7.46655 0 0 0 0 0 A0A8P0NWL9 A0A8P0NWL9_CANLF Contactin associated protein 1 CNTNAP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; paranodal junction [GO:0033010] ANLTLDGYVQRF;DPALHCNCDADQPQ;DYFPLTEQKFSLLVDS;IDPEIQRYNTP;PGYHGPGYRLPEYPRP;PYCQWRRPYVRVELNTSRDVVFAF;QVDYFPLTEQK;STDSAPAVLLYVSS 8 8 1.0038 -0.82533 0 9.11712 10.309 0 0 0 9.03705 9.6237 0 0 0 9.4624 0 0 0 A0A8P0NWM7 A0A8P0NWM7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PAK5 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cytoskeleton organization [GO:0007010] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] PSLDDYDRRPK 1 1.7 0.97973 0.035491 0 0 0 5.58809 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NWP3 A0A8P0NWP3_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 16 ADAMTS16 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] HLFNEVWRWA;IAEKTDDTCRDHF;SVELERTCTPFPC 3 2.9 0.98843 -0.34463 0 11.8679 0 0 0 0 0 0 0 0 7.94398 11.2086 0 0 12.0757 A0A8P0NWR3 A0A8P0NWR3_CANLF Matrix metallopeptidase 16 MMP16 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012]; membrane [GO:0016020] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] IPESPQGAFVHKEN;LVAVHELGHA;VFQFKRKGTPRHIL;WKGIPESPQGAFVHKENGFTYFYKG 4 8.7 0.99111 -0.54635 12.2154 0 9.32468 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NWT2 A0A8P0NWT2_CANLF Chromosome 27 C12orf4 homolog FERRY3 C27H12orf4 Canis lupus familiaris (Dog) (Canis familiaris) GVKLHRLQTALSLY;HFESQQDL;QPSQFRESVEANGRIYEEQRKLE 3 8.8 1.0014 -0.9973 0 0 0 0 9.5226 0 8.09708 0 2.56842 0 3.84197 0 0 0 0 A0A8P0NWU0 A0A8P0NWU0_CANLF calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) CAMK2G Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] LGGSAGCH;VGRQSSAPASP 2 3.5 1.0029 -1.3299 0 0 0 0 0 0 11.9694 0 0 0 0 0 0 0 6.17704 A0A8P0NWU4 A0A8P0NWU4_CANLF Olfactory receptor OR5AK8 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAMAVDRYVAICNPL;LFIAFLVIYVA;QDVKEALKGIRKK;TVFVGFNLMFTVLVVI 4 17.8 0.99385 -0.14926 0 0 0 0 0 0 0 8.64649 0 0 0 0 10.1949 10.4251 7.7383 A0A8P0NWW3 A0A8P0NWW3_CANLF Retinol dehydrogenase 11 RDH11 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491] ITFLLLLLLLLPLFL;LLLLLLLL;LLLLLLLLP;LLLLLLLLPLFLYIAAPQIR;LLLLLLLP;LLLLLLPL;SPFMKWMWWLFSFFIKTPQ 7 16.9 0.85648 0.15481 0 0 2.90668 6.65435 0 0 0 0 0 0 7.47021 0 0 0 0 A0A8P0NWX7 A0A8P0NWX7_CANLF AarF domain containing kinase 5 ADCK5 Canis lupus familiaris (Dog) (Canis familiaris) GAVYQNIYGASL;GLCSFNHLLPP;LVELMHPSFGFSWVLQR 3 6.8 0.97636 0.046227 0 0 7.35067 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NWY6 A0A8P0NWY6_CANLF Thiamine pyrophosphokinase (EC 2.7.6.2) TPK1 Canis lupus familiaris (Dog) (Canis familiaris) thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] ATP binding [GO:0005524]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788] QPLDKCVRHLWSKALLR;YDTMEGERERFYLLF 2 10.5 0.95137 0.053874 0 0 0 0 0 0 0 0 0 0 9.76252 0 0 0 0 A0A8P0NX11 A0A8P0NX11_CANLF Sperm associated antigen 9 SPAG9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] MAP-kinase scaffold activity [GO:0005078] GIENKAFDRNTESLFE;QEKKDLQT;QWKFQELSQPRSHTSLKD;SLLGGITVVGCSTEGV;VLMERNQYK 5 5.1 1.0019 -1.2557 7.45096 0 0 0 0 0 0 3.33914 0 9.74586 0 8.93805 0 0 0 A0A8P0NX16 A0A8P0NX16_CANLF Transient receptor potential cation channel subfamily V member 4 TRPV4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ANLFEGEDGSPSPSPAD;HIWKLQWATTILDIERSF;IEAYLAVMVFALVL;LVSLLNPCANMKVCSEDH;NLEAVLNSDGLSPLMMAAKTGK;SPLMMAAKTGKIGV 6 11.2 1.0029 -0.89408 0 0 10.0839 0 0 0 0 0 9.0786 0 0 0 0 9.10397 9.59949 A0A8P0NX22 A0A8P0NX22_CANLF Lysophosphatidylglycerol acyltransferase 1 LPGAT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] ETDDLADWLYQRFIEKEELLSHFYE;GSPAGGDAKELESKSKGLQ;KAVSKDEAVMLVNHQ;YQRFIEKEE 4 16.5 1.004 -1.0799 0 0 0 11.8709 0 10.8258 10.8888 0 0 0 0 0 0 0 0 A0A8P0NX33 A0A8P0NX33_CANLF Septin 9 SEPTIN9 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105] GTP binding [GO:0005525] AGGPGAGGLV;CAGGSVCRRAVCRRVSVQEGRVQE;PMSQLQSRLEPKPQPTVA;QTLENSEHTPMSQLQSRLEPKPQP;VPAAPTAD 5 7.6 0.98727 -0.23443 0 4.87041 0 0 0 0 0 0 0 0 0 0 12.0782 0 0 A0A8P0NX34 A0A8P0NX34_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAAGAGVGAAAAAAAAAAAL;EGHGGVNGPRVVFDG;HLLLLLLLLLLLG;HPLSGDVVLGEVDLHHR;IKGKDVLHKLRVIVIPVGHL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLGTAP;LLLLLLLLLL;LLLLLLLLLLL;VLHKLRVIVI 11 10.4 0.9514 0.053849 0 0 0 0 0 0 11.8619 0 0 0 0 0 0 0 0 A0A8P0NX53 A0A8P0NX53_CANLF Transient receptor potential cation channel subfamily V member 1 (Osm-9-like TRP channel 1) (Vanilloid receptor 1) TRPV1 Canis lupus familiaris (Dog) (Canis familiaris) dendritic spine membrane [GO:0032591]; postsynaptic membrane [GO:0045211] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216] DKWDRFVKRIFYFNFFIYCLYMII;DSEEASMDCSY;LVFLFGFSTAVVT;LYFCHHKEYVASM;NWGSSDSGGSEDPPQED;NWGSSDSGGSEDPPQEDS;PHIFPTAKSRSRLFG;PQEDSCLD;VLHALVEVADNTAD;VQSLFMLGTVVLYFCHHK;VTGEILSV 11 16.7 1.0027 -1.4835 0 12.5758 6.38852 0 4.60721 0 14.0773 8.01931 9.34587 9.12026 10.5252 0 10.7093 0 0 A0A8P0NX55 A0A8P0NX55_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] ESKDITVFF;GLSICTTCHLSVV;VGNFFILVRH 3 11.3 1.0023 -0.65131 0 0 0 0 0 9.024 0 0 0 0 2.66193 0 0 5.24295 0 A0A8P0NX56 A0A8P0NX56_CANLF Thyroid hormone receptor interactor 10 TRIP10 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; signal transduction [GO:0007165] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; lysosome [GO:0005764]; plasma membrane [GO:0005886] lipid binding [GO:0008289] SPIGHCVAIYHFEG 1 2.6 0.98925 -0.1968 0 0 0 0 0 0 0 0 0 0 0 9.53939 0 0 0 A0A8P0NX58 A0A8P0NX58_CANLF Netrin G2 NTNG2 Canis lupus familiaris (Dog) (Canis familiaris) AAAGSAVGSISGP;ASGDYDICKSWVTTDE;ELGADCECYGHSN;HCRLGYYRN;KEKHVRFEVRD;NIEVIGRCKCNLHA;PKAPVATV;VLCTEEYSRWAG 8 14.3 1.0023 -1.3693 0 5.9979 7.17931 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NX86 A0A8P0NX86_CANLF UDP-N-acetylglucosamine pyrophosphorylase 1 UAP1 Canis lupus familiaris (Dog) (Canis familiaris) uridylyltransferase activity [GO:0070569] AELGSSGR;EKYHGNKCVI;GGLTWMWGGL;GPSGPGEGGGRPSADPLRGPPPRT;QDQLQAWESEGL;RTMESTKEFFTKHKYFG;WGGLGPGG 7 11 0.99722 -3.6268 9.46062 0 0 0 10.4374 0 0 0 0 7.51877 0 0 0 11.0992 9.71912 A0A8P0NX89 A0A8P0NX89_CANLF "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] metal ion binding [GO:0046872]; superoxide dismutase activity [GO:0004784] FNQDPLQGTTVWTLPLCYLMVERRT 1 8 0.97461 0.035538 0 0 9.40376 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NXA0 A0A8P0NXA0_CANLF Transformer 2 alpha homolog TRA2A Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ESRSQSKSPTGTPARVKS;GGGGGGGG;SNRRRHTGSRA;SPYYSRYRSRSRSRS 4 21.1 0.87929 0.13769 0 0 0 0 0 0 0 8.58759 0 6.89845 0 0 0 0 0 A0A8P0NXA6 A0A8P0NXA6_CANLF Histone deacetylase 11 HDAC11 Canis lupus familiaris (Dog) (Canis familiaris) PGGGAGSPL;TSHWPSRAMDMNGTSWVTS 2 7.6 0.98978 -0.22228 10.6334 0 0 0 0 0 0 0 0 0 5.24762 0 0 0 0 A0A8P0NXB8 A0A8P0NXB8_CANLF Centrosomal protein of 162 kDa CEP162 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] centriole [GO:0005814]; cytoplasm [GO:0005737]; microtubule [GO:0005874] EELDEEFEQFMR;ETNKKQRWLHFGETADP;FEETNKKQRWLHFGET;FMRELSDDSFDN;QCQNDFSGYC;QEVLLKHFQNQVD;TGEKLYQIK;YAENQELLDKD 8 6.3 1.0021 -1.478 0 0 7.68713 0 0 2.66753 0 10.0207 10.1818 0 9.84967 0 9.42999 0 0 A0A8P0NXE6 A0A8P0NXE6_CANLF AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) AP5M1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] membrane [GO:0016020] FYNRGPITHVESKVSFGQLEV 1 4.7 0.98497 -0.24679 0 0 0 0 0 0 0 0 10.1726 0 0 0 0 0 0 A0A8P0NXE7 A0A8P0NXE7_CANLF Holocytochrome c-type synthase (EC 4.4.1.17) HCCS Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872] KGCPVSAEPSDPTCENKMSSVPAH 1 9.5 0.97424 0.041303 0 0 0 0 0 0 0 0 6.37283 0 0 0 0 0 0 A0A8P0NXG3 A0A8P0NXG3_CANLF Olfactory receptor OR7G5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LDSCILSVMAYDRYVAI 1 5.4 0.98673 0.046227 0 0 9.26512 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NXG8 A0A8P0NXG8_CANLF RNA helicase (EC 3.6.4.13) DHX36 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] DLRYIEMQHFR;DRDSEYLLQE;GGGGGGGG;GVHLARLPVEPHIGKMILF;HGGSRGPG;ILQWLQSD;KDSEAQISWFAPEDHGY;PGGGGGGG;VGAVTPRR;VTQFILDD 10 8.9 1.0019 -2.6397 6.45858 13.4204 0 0 0 11.4646 0 13.3618 0 0 0 13.477 0 0 6.43779 A0A8P0NXL2 A0A8P0NXL2_CANLF SET binding factor 2 SBF2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] DGQSAQQWMDRIQSCISDA;DWMMLTPKQFPSEDSE;ELILHPDL;ENDFLTKVLNG;EVEVSGLIQPAEVFAP;GVHGYRDKCFTQ;LDSDYERL;NETRVQELIQ;VHQVHNQYPTEFE;WFPQLHRIMQ 10 6.6 1.003 -2.2026 7.40386 0 0 0 9.97928 0 0 0 0 0 12.2766 13.2872 0 0 10.9868 A0A8P0NXM1 A0A8P0NXM1_CANLF RALBP1 associated Eps domain containing 1 LOC102156511 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] AAFHLVVARKNGC;ELQQQLKDVLEERISL;MPEQPNFAD;PASVQDQTTVR;QSSEQWETFIPIRM;RNSFDHSLTY 6 10.5 1.0021 -0.9029 0 0 0 0 0 0 0 0 11.7465 0 0 6.79064 9.96253 7.44766 0 A0A8P0NXN3 A0A8P0NXN3_CANLF Scavenger receptor class A member 3 SCARA3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DHEENMHDLQ;IFTNINATDNHVHSMLKYLDDVRL;QAIYDKKLMSM 3 7.6 0.98965 -0.53076 0 0 0 0 0 0 0 0 0 8.91459 0 0 0 13.3468 0 A0A8P0NXN8 A0A8P0NXN8_CANLF Mediator of RNA polymerase II transcription subunit 14 (Mediator complex subunit 14) MED14 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] CHNTILHQLQEMFNKT;DELQVLEKFF;ERWGDLVQVERYHAGKCLSLSVWN;FIKLTRLPQYY;QVLGRKTGTASVHKV 5 5.6 0.98936 -0.31204 9.81546 10.1038 11.9683 3.71348 0 0 11.4471 0 8.99551 0 0 0 0 0 0 A0A8P0NXN9 A0A8P0NXN9_CANLF Neurotrophin receptor-interacting factor homolog ZNF274 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ATYSPSEVGE;DSAPATYSPSEVGE;KSPQSQANTSLVTSHISLQKT;LVSVGWETTLESKE;VGWETTLESKELTP 5 8.7 0.98765 -0.46198 0 0 0 0 0 6.78777 0 8.66487 0 0 0 6.01351 0 0 0 A0A8P0NXP5 A0A8P0NXP5_CANLF Multiple PDZ domain crumbs cell polarity complex component MPDZ Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] AALLTRWQRIMG;ADLALVDTN;DEFDQLIKN;DVTKDMVLSPL;GVAAKDGRLKVGDQILAVDDE;LHMIELEKGRSGL;LLKTAKTT;LVPGGIAE;NAAYSNWNQPRRVEL;THQQAISILQKA;VTKDMVLSPLNASGNKGYPLL 11 6.2 1.003 -1.7413 8.62311 0 0 0 0 10.825 0 0 0 0 7.84536 0 0 11.893 9.76222 A0A8P0NXP8 A0A8P0NXP8_CANLF Elongator complex protein 5 ELP5 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] DLDQEDPDDD;LLKALVKKSA 2 6.6 1.0023 -1.2229 0 0 0 0 0 0 0 0 3.3114 0 4.25361 0 0 0 0 A0A8P0NXQ1 A0A8P0NXQ1_CANLF 3'-phosphoadenosine 5'-phosphosulfate synthase 1 PAPSS1 Canis lupus familiaris (Dog) (Canis familiaris) sulfate assimilation [GO:0000103] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; sulfate adenylyltransferase (ATP) activity [GO:0004781] FISPYTQDRNNARQI;IVPVDASYEVKELYVPE;VKLSNSNAQNWYLEGINH;WNDGLDQYRFTPTELKQK 4 10.3 0.98798 -0.48993 0 0 10.1642 0 0 8.36457 0 0 9.76203 0 0 0 0 8.5588 0 A0A8P0NXU5 A0A8P0NXU5_CANLF Solute carrier family 17 member 3 SLC17A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ATRMVQGLVQGSIFG 1 3.2 0.9939 -0.17383 0 10.2075 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NXW2 A0A8P0NXW2_CANLF TOG array regulator of axonemal microtubules 1 TOGARAM1 Canis lupus familiaris (Dog) (Canis familiaris) DEDWEKKIEGLNFIRCL;KLVSQKSSDPPGE;NHQDKVYASLNF;QSAHCHCGDNTRDNMQIYGS;TNVSGKYGQ;TVKVLLHK 6 4.5 1.0029 -1.6278 11.5707 0 10.6482 10.2952 0 0 0 0 0 0 0 9.22427 11.479 10.5712 9.78498 A0A8P0NXY6 A0A8P0NXY6_CANLF SOCS box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GSPGCVMD;LSLCRVAVRRVLGKYRLH;YHASRVGRAD 3 11.1 0.97635 0.048313 0 0 0 0 5.40354 0 0 0 0 0 0 0 0 0 0 A0A8P0NY15 A0A8P0NY15_CANLF cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] cAMP binding [GO:0030552] PDESSSCCHG;PSDYFDCAPDESSSCCHG;SIVQLCTARPERP;YTEEDAAS 4 9.2 1.0021 -1.0023 0 0 0 0 0 0 0 0 0 0 0 0 5.90468 4.73498 0 A0A8P0NY24 A0A8P0NY24_CANLF PDZ domain containing 7 PDZD7 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] EYCWLDRLSHGVLQQLSPA;QAWESRRP;SPIEERAGLC 3 3.5 1.0031 -0.78254 0 0 0 0 0 0 0 0 0 8.953 0 0 0 10.0783 0 A0A8P0NY47 A0A8P0NY47_CANLF Tubulin beta chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200] EPYNVTLSIHQLVE;LVDLEPGTMDSV;SDEHGIDPTRTYHGDNDLQ;SQQYQALTVPE;SVVPSPKVSDTVVEPYN 5 17 1.0022 -0.74066 0 0 0 0 0 10.3916 0 0 10.5906 0 0 0 0 0 0 A0A8P0NY85 A0A8P0NY85_CANLF PALM2 and AKAP2 fusion PALM2AKAP2 Canis lupus familiaris (Dog) (Canis familiaris) GTEPLLLH;PRACTPALPPTQ;VLDNDVAREIRYLD 3 2.8 1.0028 -1.3414 0 0 0 0 0 0 12.0673 0 0 0 0 8.82289 0 0 0 A0A8P0NY86 A0A8P0NY86_CANLF inositol-polyphosphate 5-phosphatase (EC 3.1.3.56) INPP5A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] inositol-polyphosphate 5-phosphatase activity [GO:0004445] GSLFDDCGASDRVL;KGFVRTRWCVAD 2 6.3 0.93632 0.060938 0 0 8.79211 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NY89 A0A8P0NY89_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] CRRRRRRRRHRLSLQPRGLFRAAV 1 4.5 0.97352 0.041303 0 0 0 0 0 0 0 0 0 5.58247 0 0 0 0 0 A0A8P0NY91 A0A8P0NY91_CANLF Hydroxyacyl-CoA dehydrogenase HADH Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] NAD+ binding [GO:0070403] GKVSGSQETGTVTWLHTPHC 1 11.2 0.95185 0.053374 0 0 0 0 0 0 0 0 9.87946 0 0 0 0 0 0 A0A8P0NY96 A0A8P0NY96_CANLF N-acetylated alpha-linked acidic dipeptidase 2 NAALAD2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ALASFLAGFTAGW;CLHLWMCGAAALA;IEIFNTSYLEPPPDGY;RLFLTMDWQDEDY;SIYNLSKKH;VLLSYPNETNVNYI;WLEKDPSSENTNFPRI 7 11.3 1.0004 -0.93037 9.85496 10.0996 0 8.68748 0 0 0 9.62965 0 0 0 0 9.3726 0 0 A0A8P0NYA2 A0A8P0NYA2_CANLF D-dopachrome decarboxylase (EC 4.1.1.84) DDT Canis lupus familiaris (Dog) (Canis familiaris) melanin biosynthetic process [GO:0042438] lyase activity [GO:0016829] KPEDRVNVTVRPG 1 12.7 0.94048 0.059587 0 0 0 0 5.74462 0 0 0 0 0 0 0 0 0 0 A0A8P0NYA4 A0A8P0NYA4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) PIK3R4 Canis lupus familiaris (Dog) (Canis familiaris) late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ITQPIIQIERKLVLLSVLKE 1 1.5 0.97408 0.048206 0 0 0 0 0 0 0 0 0 0 0 0 0 6.89639 0 A0A8P0NYA6 A0A8P0NYA6_CANLF C->U-editing enzyme APOBEC-1 (EC 3.5.4.36) (mRNA(cytosine(6666)) deaminase 1) APOBEC1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] cytoplasm [GO:0005737]; nucleus [GO:0005634] hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] IRCSITWF 1 3.4 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.39534 A0A8P0NYB4 A0A8P0NYB4_CANLF Antizyme inhibitor 1 AZIN1 Canis lupus familiaris (Dog) (Canis familiaris) polyamine biosynthetic process [GO:0006596] catalytic activity [GO:0003824]; ornithine decarboxylase activator activity [GO:0042978] EVELKKIARNH;GADSLHEP;MMSFSDWYEMQDA 3 7.2 1.0019 -1.3054 0 9.36654 6.36457 0 9.1696 0 0 0 0 8.56659 0 0 0 0 0 A0A8P0NYB7 A0A8P0NYB7_CANLF Exoribonuclease phosphorolytic domain-containing protein EXOSC6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178] GSAYLEAG 1 2.9 0.99002 -0.2636 8.56503 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NYD2 A0A8P0NYD2_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 7 ADAMTS7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GVQPCLSWYI;PCPACVPCRWWTGEW;RVEARRERWEQRQQWRRQRPRRLSQ 3 3.6 0.95056 0.053874 0 0 0 0 0 3.47275 0 0 0 0 0 0 0 0 0 A0A8P0NYE2 A0A8P0NYE2_CANLF Zinc finger protein 592 ZNF592 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ASRFFGEALEFNSHPSN;GSDLPPDPHSL;QEWVPDRENYVSHMK;VLEALAKFPVPELHMFDHFCKKEPK 4 5.5 0.99572 -0.10009 0 0 0 0 9.01268 0 0 10.6334 0 0 0 10.2347 0 9.72952 7.21053 A0A8P0NYF1 A0A8P0NYF1_CANLF Cyclin-dependent kinase 7 (EC 2.7.11.23) (Cell division protein kinase 7) CDK7 Canis lupus familiaris (Dog) (Canis familiaris) transcription factor TFIIK complex [GO:0070985] ATP binding [GO:0005524]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353] DMWAVGCILAE;IFETLGTPTE;LQELSHPNII 3 10 1.0023 -0.72758 0 0 0 0 0 0 0 0 9.31911 0 10.2053 0 0 0 0 A0A8P0NYJ0 A0A8P0NYJ0_CANLF HSPA (Hsp70) binding protein 1 HSPBP1 Canis lupus familiaris (Dog) (Canis familiaris) RGQREEVEQMKNCLR;SFKNPLPCIWQV 2 5.7 0.99028 -0.19849 0 0 0 0 0 9.87613 0 0 0 8.19992 0 0 0 0 0 A0A8P0NYJ2 A0A8P0NYJ2_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) AXL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein tyrosine kinase activity [GO:0004713] EADPFVGSPRNITGARGLTG;LGYRLAYRGQD;QEPEEILYVNMDEGGSH;QGEPPEVTWLR;SLHPHTPYHIRVACTSSQGPSPWT;VSEPPAPA 6 10.4 0.97293 0.041303 0 0 0 0 0 0 0 0 0 0 0 8.81202 0 0 0 A0A8P0NYJ6 A0A8P0NYJ6_CANLF Developmental pluripotency associated 5 DPPA5 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] RCGETFVRWESAARTRREVTCESR;YGSYLYKLRAKWMLQ 2 13.3 0.99425 -0.28554 0 0 0 9.21463 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NYK9 A0A8P0NYK9_CANLF Methyl-CpG binding domain protein 1 MBD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DCGHCDFCCD;LPRCAPHNEGWYVV;VGCGECAA 3 4.9 0.93649 0.060949 0 0 0 0 4.83335 0 0 0 0 0 0 0 0 0 0 A0A8P0NYM6 A0A8P0NYM6_CANLF Microcephalin MCPH1 Canis lupus familiaris (Dog) (Canis familiaris) cerebral cortex development [GO:0021987] centrosome [GO:0005813] KMCSGQHSTMLRRLQE;REHLPSLIKKKRK;VGGAVPSPGPSRPMGDVVAYVE 3 5.6 0.85024 0.15789 0 0 6.38106 0 0 0 0 9.76504 0 0 5.64801 0 0 0 0 A0A8P0NYN0 A0A8P0NYN0_CANLF Cyclin dependent kinase inhibitor 2D CDKN2D Canis lupus familiaris (Dog) (Canis familiaris) GALPIHLA;QGASPNVQ;VQEVRRLLHRELVHPDA 3 19.9 1.0025 -1.1456 0 0 7.24394 7.02658 7.03166 8.38672 0 0 0 0 0 0 0 0 0 A0A8P0NYN4 A0A8P0NYN4_CANLF Early endosome antigen 1 EEA1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ADELFKHYE;CKELKHQLQVQTEN;ELLATRQDLKSV;HYEVVHDAGNDSSH;IVSSTKLDL;LSQDAKMQHKEL;MFRRILQRTPGRV;NTTAAVQELGREN;QDRVLSLETSVNE;QHKELNNKIQ;QTENFNIKQ;VTHLTEEL 12 9.1 0.99889 -3.1408 0 0 11.0221 12.4419 0 0 10.317 0 11.2938 0 0 9.54861 14.7406 10.1219 0 A0A8P0NYP5 A0A8P0NYP5_CANLF "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)" Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" mitochondrial respiratory chain complex IV [GO:0005751] metal ion binding [GO:0046872] IVSIFIINMEKQDKEEA 1 14 0.97618 0.046227 0 0 0 0 0 0 7.97212 0 0 0 0 0 0 0 0 A0A8P0NYQ9 A0A8P0NYQ9_CANLF C-type lectin domain containing 7A CLEC7A CLEC1A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DFTSLRNRDCVTILNGK;SVQSRASS 2 13.3 1.0018 -1.364 0 0 0 0 0 0 11.7738 0 0 0 0 0 0 7.29747 0 A0A8P0NYR4 A0A8P0NYR4_CANLF chymotrypsin (EC 3.4.21.1) LOC479649 Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] DAVPGSWPWQVSL;GDSGGPLVCQKDGA;IAKVFKNPK;LVGIVSWGSGWCN;SGGPLVCQKDGAWTLVGIVSWGS 5 20.4 0.98885 -0.30945 0 0 0 0 9.26357 7.65843 0 0 8.6551 5.80041 0 6.40973 7.63677 10.0048 0 A0A8P0NYS4 A0A8P0NYS4_CANLF Mitochondrial Rho GTPase (EC 3.6.5.-) RHOT1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion organization [GO:0007005]; small GTPase-mediated signal transduction [GO:0007264] mitochondrial outer membrane [GO:0005741] calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] FDKHDLDRDCAL;PEEVPPRAEEIT 2 4 0.98775 -0.26024 0 0 0 8.13673 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NYU3 A0A8P0NYU3_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR35 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] ASPLPPADPHGLEAPGPPAA;GTCARPHPTWVE;RPWTETRVYMV 3 7.5 0.98528 -0.23556 0 0 0 9.45921 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NYW1 A0A8P0NYW1_CANLF Delta(14)-sterol reductase LBR (C14SR) (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Integral nuclear envelope inner membrane protein) (Lamin-B receptor) (Sterol C14-reductase) LBR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695] endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637] delta14-sterol reductase activity [GO:0050613] AALCRGVELHYVY;FIYSFQAF;TRAFAIYFFWFSLQAL;TSEVLGTQP 4 8.2 1.0034 -1.6382 8.32418 0 0 0 0 0 0 0 0 0 0 0 0 8.06604 0 A0A8P0NYW3 A0A8P0NYW3_CANLF Gamma-aminobutyric acid type A receptor subunit alpha6 GABRA6 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] GAAGGAKP;PGFGGAVT;VSYATAMDW 3 4.9 1.0021 -1.3703 0 0 0 0 10.9391 0 11.3927 0 0 0 0 0 0 0 0 A0A8P0NYW4 A0A8P0NYW4_CANLF DDB1 and CUL4 associated factor 8 DCAF8 Canis lupus familiaris (Dog) (Canis familiaris) EEEEEEEEEEEHP;EEEEEEEEEHPRRR;LYTIYVNPANTHQFAVGG;TCLVYSHDGTELLA 4 8.1 0.99729 -0.10855 0 0 0 0 0 0 0 0 9.03919 0 0 0 0 0 12.0702 A0A8P0NYW6 A0A8P0NYW6_CANLF Oxysterol-binding protein OSBP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] membrane [GO:0016020] lipid binding [GO:0008289] DEDTEYFDAME;DIEIVNHKTKDRC;EDSEEDEDTEYFDAMEDSTS;EEDEDTEYFDA;EYFDAMEDSTSFITVITEAKEDRK;GASMSSLNKWIFTVHGFG;LGETFELD;MPLGAIHLEFQ;PTPPPALVPVQQRRR;SGSFLEGREWGAEGCPGDRE;VPLDLAQLATT 11 14.8 1.0032 -2.4056 0 0 10.7051 3.56145 0 5.86639 11.4871 0 10.2796 8.71778 0 0 0 2.47236 13.6957 A0A8P0NYX2 A0A8P0NYX2_CANLF Serine/threonine-protein kinase mTOR (EC 2.7.11.1) MTOR Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of autophagy [GO:0010507]; positive regulation of protein metabolic process [GO:0051247]; regulation of cellular component organization [GO:0051128] TORC1 complex [GO:0031931] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877] ALEWLGAD;AVLEAFVYD;DKARDLLDAELTAMAG;DVGSITLALR;ERFDAHLAQAENLQALFVALND;GADRNEGRRH;HEFVFLLKGHE;KGYTLADEEEDPLIYQHRM;MCRDLELAVPGTYDPNQPII;MLRMAPDYDHLTLM;MWKSTRKIDAFQHMQ;PERREIIRQIW;PILKALILKL;SWYKDLSKTLLMYTVPAVQ;TWLQVIPQLIARIDTPRPLV;VGRLIHQLL;VMAVLEAFVYDPL;YLHLLLPPIVKLFDAPEVPL;YMKNMWKSTRKIDAFQHMQHF 19 10.1 0.94957 0.049568 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.80639 A0A8P0NYX9 A0A8P0NYX9_CANLF Protein MCM10 homolog MCM10 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication initiation [GO:0006270] nucleus [GO:0005634] double-stranded DNA binding [GO:0003690]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] EQLTYLESEEFQKIL;GVSSASYAASVAAAVAPK;ISEGDDVL;YDELFDADDDGESYSEEATDGELG 4 8.3 1.0019 -0.67043 9.85613 0 0 0 0 0 7.57304 0 0 0 0 0 0 0 0 A0A8P0NYY0 A0A8P0NYY0_CANLF Protein kinase cAMP-dependent type II regulatory subunit beta PRKAR2B Canis lupus familiaris (Dog) (Canis familiaris) regulation of protein phosphorylation [GO:0001932] cAMP-dependent protein kinase complex [GO:0005952]; plasma membrane [GO:0005886] cAMP binding [GO:0030552]; cAMP-dependent protein kinase regulator activity [GO:0008603] EEPARTDSEDAEEEEEAAD;TFDIYVKCDGVGR 2 8.4 0.99169 -0.1815 9.02326 0 0 0 0 0 0 0 0 9.24334 0 0 0 0 0 A0A8P0NYY2 A0A8P0NYY2_CANLF Small ribosomal subunit protein eS17 (40S ribosomal protein S17) RPS17 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic ribosome [GO:0022626]; ribonucleoprotein complex [GO:1990904] structural constituent of ribosome [GO:0003735] CFLFYYTRQHGRYLGPRPSSP;EERERRDNYVP 2 12 0.96126 0.048782 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5381 0 A0A8P0NYY5 A0A8P0NYY5_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT5 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] EADPAVPE;KKLKCKSFKWYLENV;LHKSASVFHPELVNHIVFG;QAAAAAAPAAPAPAEPPRA;SSELQQFNYTWL 5 8.3 1.0027 -1.1909 10.46 0 0 0 0 0 9.76183 0 0 0 4.77595 7.44576 0 0 7.08736 A0A8P0NYZ0 A0A8P0NYZ0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DLQRFRGSPGIDLDNH 1 6.8 0.95795 0.049233 0 0 0 0 0 0 0 0 7.36177 0 0 0 0 0 0 A0A8P0NZ01 A0A8P0NZ01_CANLF Large ribosomal subunit protein uL11 (60S ribosomal protein L12) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] IDEINSYAVECPES 1 10.6 0.94151 0.061086 0 7.61993 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NZ23 A0A8P0NZ23_CANLF Dual specificity phosphatase 22 DUSP22 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] LLDLLRAPCSL 1 4.1 0.9938 -0.072154 0 0 0 0 0 0 0 11.5947 0 0 0 0 0 0 0 A0A8P0NZ26 A0A8P0NZ26_CANLF F-box and leucine rich repeat protein 18 FBXL18 Canis lupus familiaris (Dog) (Canis familiaris) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] LYFEILDRTREG;PCSRAQNVGDSEVAAIGQLAF;PGFDAGQLSGECKA;RDPMGIWCSPYF 4 8.1 1.0013 -0.70852 8.98105 0 0 0 0 0 0 0 0 0 0 12.2204 0 14.1394 0 A0A8P0NZ50 A0A8P0NZ50_CANLF Catsper channel auxiliary subunit zeta Canis lupus familiaris (Dog) (Canis familiaris) flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240] CatSper complex [GO:0036128] VGCRPGDLHGHL 1 6.2 0.94328 0.05044 0 9.36774 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NZ56 A0A8P0NZ56_CANLF Small ubiquitin-related modifier 1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; PML body [GO:0016605] KPSTEDLGDKKEGEEIP 1 25 0.98246 0.046227 0 0 0 0 0 5.74586 0 0 0 0 0 0 0 0 0 A0A8P0NZ64 A0A8P0NZ64_CANLF Sorting nexin 8 SNX8 Canis lupus familiaris (Dog) (Canis familiaris) "retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] QENAIQTMELRSY;SEFTELSHREAEAQR;VFHEMLLH;YRRYNDFVVF 4 8 0.93456 0.068595 0 0 0 0 0 0 0 0 0 0 9.14873 0 0 0 0 A0A8P0NZ66 A0A8P0NZ66_CANLF Protein kinase C (EC 2.7.11.13) PRKCG Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] dendrite [GO:0030425]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; zinc ion binding [GO:0008270] KKDVIVQDDDVDCTL;TTRTFCGTPDYIAPEI 2 4.5 0.94448 0.076616 0 0 0 0 0 0 0 0 0 0 0 0 8.63811 0 0 A0A8P0NZ78 A0A8P0NZ78_CANLF Exocyst complex component EXOC6B Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle tethering involved in exocytosis [GO:0090522] exocyst [GO:0000145] ESIRKHSDKIGETAMKQAQ;IDELWEMALSKTI;VEDEEDDEEVPG 3 6 0.86757 0.14416 7.20134 0 0 0 0 0 0 0 0 0 0 0 9.27226 0 0 A0A8P0NZ93 A0A8P0NZ93_CANLF DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) POLR2B Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549] AEHSGNAG;DIREREIRI;EDMQYDEDDDE;EDMQYDEDDDEITPDL;EDPEMMEMVK;FEASDPYQ;IIYDFEDPEMME;IVEKQKLLLKKRHI;LDPGGYFI;PETGARDYWWAV;PLLIVEKQKLLLK;TSETGIVDQ;VGSQPSPILEFLEEW 13 9 0.99874 -2.9883 8.8553 9.76388 0 10.4798 8.89766 8.44394 8.82731 0 7.81012 10.0682 9.12616 0 12.9056 10.1737 2.42804 A0A8P0NZ96 A0A8P0NZ96_CANLF Amyloid beta like protein 1 APLP1 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] heparin binding [GO:0008201]; transition metal ion binding [GO:0046914] EEAAAAAAALGAPVT;GEFVSEALLVPEGCRFLHQERM;LSLLLLRRKKPYGAISHGV;PLLLLLLRAQ;SLPLLLLLLRAQLAVGS;SSGKEKMSPLE;TDGVDVYFGMPGE;VLEYCRQM 8 13.6 0.95052 0.049546 0 0 0 0 0 0 0 0 7.70287 0 2.73205 0 0 0 0 A0A8P0NZE4 A0A8P0NZE4_CANLF Myosin binding protein H MYBPH Canis lupus familiaris (Dog) (Canis familiaris) GLEAKAAIDILVIEKPGPPSSIRLL;LSATAATTKELARIQ;RTESVWAPEGTLFLTP;SILTNTSQQAHAKEMHPVGG;TLVLKLLVAASL 5 15.4 0.92491 0.095886 7.36641 9.96175 0 7.28854 0 0 0 0 0 12.3765 0 0 0 0 0 A0A8P0NZG9 A0A8P0NZG9_CANLF Neurexin 2 NRXN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] AAALTRRA;AEQDDSDCE;AEQDDSDCEE;IITEDSLDPP;LDGGQMKLTV;LDLESELYLGGLPEGG;LEECEPSTGGEL;NSGNGNDFIVIELVKGYIH;PAGGPCQAEQDDSDCE;PGAPEPEEHPM;TEDSLDPPPVATRSP 11 6.9 1.0037 -1.0689 0 0 0 0 0 0 0 0 9.66574 0 0 9.60964 0 0 0 A0A8P0NZH2 A0A8P0NZH2_CANLF Zinc finger protein 550 ZNF550 Canis lupus familiaris (Dog) (Canis familiaris) LVPAMKSQMGWRCCLLLI;RFRDIGVV 2 5.9 0.99177 -0.54388 0 0 0 10.6099 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NZJ0 A0A8P0NZJ0_CANLF Beta-arrestin-2 (Arrestin beta-2) ARRB2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] APVDTNLIEFDTN;DIVFEDFAR;VLGILVSYRVKVKLVVSRGGDVSV 3 11.4 0.98692 -0.23177 3.87381 0 0 0 0 0 0 0 0 10.3942 0 0 0 0 0 A0A8P0NZJ1 A0A8P0NZJ1_CANLF Golgi associated RAB2 interactor 1B GARIN1B Canis lupus familiaris (Dog) (Canis familiaris) IKLKRILPL;LHSPEFNLFPDSVVFE 2 7.3 1.0009 -0.62519 0 9.99774 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NZL0 A0A8P0NZL0_CANLF Intersectin 1 ITSN1 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; intracellular signal transduction [GO:0035556] cell projection [GO:0042995]; cytoplasm [GO:0005737]; synapse [GO:0045202] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085] DKKRENFERGNLELE;EEPVLEDEQQ;EKQKEEAQRRAQERDKQ;EPVLEDEQQQLEKKLPV;IAEITHLQQQ;KLLKALRVRKK;KLLKALRVRKKMS;LTTDMDPSQQWCSDLH;NFFFQSGLPQP;QQDMWWFG 10 6.6 1.0038 -2.0424 0 3.8479 0 9.73335 4.73118 0 9.15069 0 8.36501 7.27752 0 0 0 0 9.14142 A0A8P0NZL1 A0A8P0NZL1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEDEADYYCSAYD;CTGSWAQSVLTQPASVSGS;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 8 28.9 0.94014 0.059561 0 6.92457 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0NZQ2 A0A8P0NZQ2_CANLF MAGUK p55 scaffold protein 4 MPP4 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] CEYDMKIDEKCVEAGS;DHVIVNDNLQD;DLAQKMETQFGQFFDH;LDVTSCAFLP;QQPLGATIKRHE;VIVNDNLQDA;YHYVSKET 7 11.7 1.0037 -1.6836 0 12.3135 0 0 0 0 0 9.83218 10.3836 0 8.93784 7.83744 0 0 0 A0A8P0NZQ4 A0A8P0NZQ4_CANLF glycogenin glucosyltransferase (EC 2.4.1.186) GYG2 Canis lupus familiaris (Dog) (Canis familiaris) glycogen biosynthetic process [GO:0005978] glycogenin glucosyltransferase activity [GO:0008466] AAPDPGWPDCFNS;QSTSVHLIYTPPAHLCLLVLFSWC;TPPAHLCLLVLFSWC 3 8.3 0.992 -0.14149 0 0 0 9.21502 0 0 9.6374 0 0 0 0 0 0 0 8.83656 A0A8P0NZR3 A0A8P0NZR3_CANLF Coronin CORO2A Canis lupus familiaris (Dog) (Canis familiaris) HYPKVCGHKGNVLD;KQLELEVKNSRMNS;NGSLLATTC 3 7.1 0.98356 -0.24785 0 0 0 0 0 0 0 0 0 6.63603 0 0 0 0 0 A0A8P0NZS3 A0A8P0NZS3_CANLF MCF.2 cell line derived transforming sequence MCF2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] ENFALTVKEMAQMLQSF;GAEETESEHSGTMVEVR;HVLNELIQTERVYVRELFTVLLGY;LHLVLVLRP;QRITKYQLLLKELLK 5 7.8 1.0001 -0.61657 4.35099 4.3365 8.01725 5.95582 0 7.76288 5.2041 0 0 0 0 7.39017 0 0 0 A0A8P0NZS4 A0A8P0NZS4_CANLF Unc-13 homolog A UNC13A Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887] presynapse [GO:0098793] calcium ion binding [GO:0005509]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543] AEVMWNLFAQD;DTIKQYFHAGGVG;EEGPGEWLTLDSQ;IVDEFAMRY;STVDLLTSITFF;VMNTMEKTIVLPPLTDQTMI;VPAVMSTLLA;VSYHKDSPRWDQDEEE 8 6.1 0.94254 0.060042 0 9.70572 13.1358 0 9.98428 0 10.8196 11.1253 11.0053 0 0 0 6.4219 0 0 A0A8P0NZS5 A0A8P0NZS5_CANLF "Metalloendopeptidase OMA1, mitochondrial (Overlapping with the m-AAA protease 1 homolog)" OMA1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] mitochondrial inner membrane [GO:0005743] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AAPVPLLLII;AAPVPLLLIILKPVQKL;EWLSTHPSHGNRAERLDR;KIREICNCPPLSGP;LLLIILKPVQKL;LLLIILKPVQKLFAIIV;LLLIILKPVQKLFAIIVGRG;LSTHPSHGNR;PEWLSTHPS;RLLFKLSMKHFLE;VPLLLIILKP;VPLLLIILKPVQKL 12 14.7 1.0028 -2.4711 9.12283 3.74578 3.5568 9.16455 0 3.0273 6.17543 10.0118 7.14639 6.98641 8.49434 3.83572 0 0 12.8852 A0A8P0NZS7 A0A8P0NZS7_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPICLMYLVAIMG;PNACFAQEFFIHGFTVMESSM 2 10.9 0.9186 0.10966 0 0 0 8.67338 0 9.06102 0 0 0 0 0 0 0 0 0 A0A8P0NZS9 A0A8P0NZS9_CANLF Hepatic triacylglycerol lipase (EC 3.1.1.3) (EC 3.1.1.32) (EC 3.1.1.5) (Lipase member C) (Lysophospholipase) (Phospholipase A1) LIPC Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] high-density lipoprotein particle [GO:0034364] heparin binding [GO:0008201]; metal ion binding [GO:0046872]; triglyceride lipase activity [GO:0004806] TSNKTYSFL;VSGFAGNYI 2 4.1 1.0035 -1.6084 0 0 11.969 8.37669 0 0 0 7.46997 0 0 0 0 0 7.68685 0 A0A8P0NZT1 A0A8P0NZT1_CANLF Cdc42 guanine nucleotide exchange factor 9 ARHGEF9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] guanyl-nucleotide exchange factor activity [GO:0005085] FFSNTTSKSVSGSSSQDSTATL;IYSEYCNNHLDAC;LQNRDQMRANVINEIMSTE;PKRSQSPFWQ;YSEYCNNHLD 5 11.5 0.98415 -0.2396 0 0 0 0 0 0 0 0 0 0 9.54438 0 0 0 0 A0A8P0NZT3 A0A8P0NZT3_CANLF Neuron navigator 3 NAV3 Canis lupus familiaris (Dog) (Canis familiaris) neurogenesis [GO:0022008] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDVGYEGC;ELLPCGYL;LETTFDST;SVPGAGAG 4 1.8 0.98949 -0.26592 0 0 0 0 0 0 0 0 9.59613 0 0 0 0 0 0 A0A8P0NZV3 A0A8P0NZV3_CANLF mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K6 Canis lupus familiaris (Dog) (Canis familiaris) MAPK cascade [GO:0000165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] APDLYCMCGRVYKD;EGPPHRAHFWL;FDVEPSLHSGINAAVLL;GVSSSKRDER;LGPEVETEAIPP;LQYMAPEIIDQGPRGYGKA;RERFSGQQLRQELARLQRRLDSVE 7 8.3 0.98797 -0.34202 0 0 0 8.07682 0 8.12856 10.4783 10.2573 10.6433 0 0 0 0 10.7107 0 A0A8P0NZV5 A0A8P0NZV5_CANLF Cyclic nucleotide binding domain containing 1 CNBD1 Canis lupus familiaris (Dog) (Canis familiaris) KFPPGHMIVE;KLEPKKAKKIKKLV;KLEPKKAKKIKKLVCMGKLKEKES;RHRSLFCSSSLSINSL;VISETWVKGSTVVGND 5 11.7 0.98908 -0.30199 0 9.01084 0 3.50868 12.2525 0 11.8131 0 0 0 0 4.11595 0 0 0 A0A8P0NZY3 A0A8P0NZY3_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] EIEDTFIADL;GVMVSPCSGEIEDT 2 9.8 0.99203 -0.55067 0 0 0 0 0 0 0 0 10.2793 0 0 0 0 9.20381 0 A0A8P0NZZ0 A0A8P0NZZ0_CANLF COP1 E3 ubiquitin ligase COP1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] CADHCVHYYDLRNT;HYYDLRNTKQPIMVFK;TSASSSLS;VGGSSSGL;VLEEDIKRVEE;YHKNLLASSDYEG 6 8.6 1.0028 -1.1619 9.38444 0 8.80539 0 0 0 10.7994 5.8594 8.73857 8.58797 0 0 8.60028 9.78606 8.59831 A0A8P0P000 A0A8P0P000_CANLF E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase makorin-2) MKRN2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; protein polyubiquitination [GO:0000209] nucleus [GO:0005634] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] EDQNKKNELIEAFKQGMGKLV 1 5.4 0.94962 0.04991 0 0 0 0 0 0 0 0 0 0 0 0 0 6.50231 0 A0A8P0P012 A0A8P0P012_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) RNF144B Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EGCGAPIACPDTVC;WRAAPHAPGARAGGRRAAG 2 7.7 0.91256 0.11071 0 8.74147 0 0 0 0 0 0 0 0 0 0 0 0 7.73417 A0A8P0P013 A0A8P0P013_CANLF Nuclear factor 1 NFIX Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AAESCLPAGPACDE;KSIDDSEMESPV;STAPDGAALTPPSPSFATTGASSA;TSGVWNVTELV 4 9.1 0.98549 -0.24601 0 0 0 0 0 0 0 0 12.4122 0 0 0 0 0 0 A0A8P0P014 A0A8P0P014_CANLF Zinc finger protein 704 ZNF704 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] EVDDDDEDGEERFPP;EVVVEVDDDDEDGEE;GAEEEDDDEEDEDE;GAEEEDDDEEDEDEE;GGAEEEDDDEED;PLSADCFKPLRSPAP;SPAPPPPPPPPPPPPPPADDGI;TTLYLVHTDHAYQV;VGDSDYSDGEEDFY 9 16.8 0.99218 -0.17677 9.46463 0 5.76014 9.16649 0 0 7.78496 11.2346 0 0 3.36457 3.44148 0 0 0 A0A8P0P016 A0A8P0P016_CANLF "RAB7B, member RAS onco family" RAB7B Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] IDLADRQYQSILENYLT 1 10.8 0.98524 0.046227 0 0 0 0 0 0 7.53559 0 0 0 0 0 0 0 0 A0A8P0P035 A0A8P0P035_CANLF RAB11 family interacting protein 1 RAB11FIP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] membrane [GO:0016020] small GTPase binding [GO:0031267] DFQSRWEDDDNEDESSSAS;DNLLVRVMEETPN;GTATIISENLINETMMKKYNPS;KKSKIKTLFSKSNLQ;LLSLVTGK;QTKAVKPRLHPVKP;SADPKQLNQSNFSL;TEPEPDRQL 8 17.6 0.93753 0.060924 0 0 0 0 0 0 0 0 0 0 0 0 6.26561 0 0 A0A8P0P039 A0A8P0P039_CANLF AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) AP5B1 Canis lupus familiaris (Dog) (Canis familiaris) endosomal transport [GO:0016197]; protein transport [GO:0015031] DLLSELRSEKLSEQT;LSVGPRRA;LYQSRPALAPHFV;QGFAAALMVQEAP;QGLEALVSH;RHAHLPPLLV 6 7.8 1.0031 -1.7313 0 0 0 0 0 0 12.6312 0 0 0 0 0 0 16.5109 0 A0A8P0P049 A0A8P0P049_CANLF G-patch domain containing 1 GPATCH1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleic acid binding [GO:0003676] EEPGDGLYGWTAPRQYKNQ;EKVSSFWVSWDRRQA;GLEPLEEGE 3 4 0.80612 0.21703 0 0 0 0 10.2227 0 0 0 0 0 0 9.26425 0 8.76228 0 A0A8P0P050 A0A8P0P050_CANLF "Large ribosomal subunit protein bL32m (39S ribosomal protein L32, mitochondrial)" MRPL32 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934]; mitochondrion [GO:0005739] structural constituent of ribosome [GO:0003735] NCWQWRRDC 1 4.1 1.0041 -0.80421 0 0 0 0 0 0 0 0 0 0 0 9.853 0 0 0 A0A8P0P055 A0A8P0P055_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) WWP2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin protein ligase activity [GO:0061630] ELLWNEIIILNV;KVHNRQPRINSFVEVAV;KYTSEGVRYFVD 3 5.5 1.0037 -0.80408 0 0 0 0 0 0 9.28425 0 9.95497 0 0 0 0 0 0 A0A8P0P063 A0A8P0P063_CANLF Non-histone chromosomal protein HMG-17 Canis lupus familiaris (Dog) (Canis familiaris) chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] ADAGEDGKNPAENGD 1 16.7 0.98668 -0.23182 0 0 0 0 0 0 0 0 0 0 0 10.6615 0 0 0 A0A8P0P067 A0A8P0P067_CANLF RNA helicase (EC 3.6.4.13) MOV10 Canis lupus familiaris (Dog) (Canis familiaris) P-body [GO:0000932] 5'-3' RNA helicase activity [GO:0032574]; RNA binding [GO:0003723] EVKETDNPGGQ;GGGGGGGG;KLYDRSLESNPEQLQAMKYI;LSPRSVGVISPYRKQVE;TVLWELLGPG 5 6.4 1.0028 -0.87046 0 0 0 11.0054 0 0 0 0 8.37795 0 0 0 0 0 0 A0A8P0P0A8 A0A8P0P0A8_CANLF "DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease" DIS3 Canis lupus familiaris (Dog) (Canis familiaris) exosome (RNase complex) [GO:0000178] "3'-5' exonuclease activity [GO:0008408]; RNA binding [GO:0003723]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]" ADLCKNLNFRHKMAQ;HYLRDDIGCGAPGCAACGG;ILKKRRIEKGALTLSSP;ILKVRFTKSVI;KLAKILKKRRI;LRGLNKLAKILKKR;SPIRRYADIIVHRLL;YLNTLLRIL 8 10.7 1.0039 -0.82892 0 10.6424 11.9906 6.79831 7.90268 0 14.009 4.59783 0 10.7885 0 10.7135 10.7043 8.17847 7.57122 A0A8P0P0A9 A0A8P0P0A9_CANLF O-acyltransferase DGAT1 Canis lupus familiaris (Dog) (Canis familiaris) triglyceride biosynthetic process [GO:0019432] endoplasmic reticulum membrane [GO:0005789] diacylglycerol O-acyltransferase activity [GO:0004144] FPRSPRIRKRFLLRRLL;LCYELNFPRSPRIRKRFLLRRLLEM;LVRGSPGTGSPAL;RKRFLLRRLLEMLFLTQLQVGLIQQ;RLFLENLIKYGILV;SPGTGSPAL;YSRIIERLLKL 7 13.1 0.98644 -0.32176 0 0 0 0 0 7.60392 0 8.7213 0 0 0 0 5.9993 0 0 A0A8P0P0B0 A0A8P0P0B0_CANLF Endoplasmic reticulum-Golgi intermediate compartment protein ERGIC1 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] PNLDYSFIQSSQLKVT;QRYSYQYTVANKEYV 2 7.1 0.9608 0.049233 0 6.87639 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P0B7 A0A8P0P0B7_CANLF Signal transducer and activator of transcription STAT3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EELQQKVSYKGDP;LQESNVLYQHNLRRIKQFLQSRYLE;QHNLRRIKQ;SRFLQESNVLY 4 5.7 0.98977 -0.52696 0 9.28214 6.72151 0 0 0 3.32769 0 0 0 0 0 0 0 0 A0A8P0P0D8 A0A8P0P0D8_CANLF Alcohol dehydrogenase class-3 (EC 1.1.1.1) (EC 1.1.1.284) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class-III) (S-(hydroxymethyl)glutathione dehydrogenase) Canis lupus familiaris (Dog) (Canis familiaris) formaldehyde catabolic process [GO:0046294] S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity [GO:0051903]; zinc ion binding [GO:0008270] NEAFDLLHAR 1 2.8 0.99275 -0.19139 0 0 0 9.6162 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P0G7 A0A8P0P0G7_CANLF Ubiquitin protein ligase E3 component n-recognin 7 UBR7 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] SEPCTSSS;VLEEDEELENEA 2 4.9 1.0043 -1.0539 0 0 0 5.71625 0 0 0 0 0 4.47684 0 0 0 0 0 A0A8P0P0I3 A0A8P0P0I3_CANLF Family with sequence similarity 118 member B FAM118B Canis lupus familiaris (Dog) (Canis familiaris) NLLELYAADQGKQLE 1 4.9 0.95221 0.0539 0 0 0 0 0 0 0 11.3863 0 0 0 0 0 0 0 A0A8P0P0J9 A0A8P0P0J9_CANLF Erythrocyte membrane protein band 4.1 like 2 EPB41L2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] cytoskeletal protein binding [GO:0008092] DEVQEDVSEEAAKRES;FGEADRIMLDSLE;NLSPVPERDLLSDIS;RCVSSLSPNLSPVPE 4 6.4 0.99391 -0.061019 0 0 5.20218 0 0 0 0 0 12.6805 0 0 0 0 6.81096 10.6604 A0A8P0P0L1 A0A8P0P0L1_CANLF CBY1 interacting BAR domain containing 2 CIBAR2 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814] LIDFANTENPEMR 1 4.8 0.98274 -0.25403 0 0 0 0 0 0 0 0 0 10.6897 0 0 0 0 0 A0A8P0P0M9 A0A8P0P0M9_CANLF Protein 4.1 (Band 4.1) (Erythrocyte membrane protein band 4.1) EPB41 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cortical actin cytoskeleton organization [GO:0030866] cell cortex [GO:0005938]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] calmodulin binding [GO:0005516]; cytoskeletal protein binding [GO:0008092] AAVDSDRSPRPTSA;DITRYYLCLQLRQ;HQQQKEEGEGVTNSGQQETQ;QDIVSGRLPCSFATLALLGSY;QKSIRRHRN;SERKSLSYFL;TEDITRYYLCLQLRQD;VPWNFTFNVKFYP 8 12.9 0.99862 -0.61146 0 10.5604 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P0N1 A0A8P0P0N1_CANLF Amyloid beta like protein 1 APLP1 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; membrane [GO:0016020] heparin binding [GO:0008201]; transition metal ion binding [GO:0046914] EEAAAAAAALGAPVT;ELAPAGTGRSPMGLS;GEFVSEALLVPEGCRFLHQERM;PLLLLLLRAQ;SLPLLLLLLRAQLAVGS;SSGKEKMSPLE;TDGVDVYFGMPGE;VLEYCRQM 8 13.8 1.0026 -0.89851 0 0 0 10.117 0 0 1.1573 15.8054 8.29177 12.1722 10.5302 0 0 0 7.18765 A0A8P0P0N2 A0A8P0P0N2_CANLF Rotatin RTTN Canis lupus familiaris (Dog) (Canis familiaris) cilium organization [GO:0044782] centrosome [GO:0005813]; ciliary basal body [GO:0036064] DIQTAVRQQL;IDGILDGLFILPS;IDIIHFLNKLL;LAEDMILIGEAISADIW;LDLLVLTESQAR;MAVTDRKC;PNIHEAVVAY;PSVFSLPVSVFRRYH;SLTLPKGG;SYHQHFPLIKEMICM;TTRLKSMLRLLFVRKPLVRS;VIDMLCTCVSLSTTCPTL;VRVLQMLLPVE 13 8 1.003 -2.1266 9.16496 10.1214 0 9.91998 0 8.43763 6.7137 0 9.66966 11.7765 0 8.68559 0 0 8.90466 A0A8P0P0N8 A0A8P0P0N8_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G5 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] CLKRNLRSYNPHYQY;QTCSSSAC 2 10.1 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 7.77294 0 0 A0A8P0P0S5 A0A8P0P0S5_CANLF ATP synthase lipid-binding protein (ATPase protein 9) (ATPase subunit c) Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial membrane [GO:0031966]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] RGRVGVAGSGAGIG 1 7.6 0.98544 -0.24686 0 0 0 0 0 0 0 0 0 0 0 0 10.2137 0 0 A0A8P0P0V4 A0A8P0P0V4_CANLF Cold shock domain containing E1 CSDE1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723] APRLMVLRQPRG;EVFYLTYTPE;GKPIAVKLVKIKPEILPEERMNGQV;GVVCAMKEAF;LLHNNGHNGYPNGTS 5 9 1.0024 -1.1236 0 0 0 0 0 0 0 8.7652 0 9.78249 0 0 8.94337 0 0 A0A8P0P0W2 A0A8P0P0W2_CANLF Eyes absent homolog (EC 3.1.3.48) EYA1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725] HLHNKFFLSSKV;LSQSQSPG 2 3.2 0.99204 -0.18461 8.84376 0 8.68724 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P0W3 A0A8P0P0W3_CANLF Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) CYLD Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; protein deubiquitination [GO:0016579]; Wnt signaling pathway [GO:0016055] cell projection [GO:0042995]; centrosome [GO:0005813]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819] cysteine-type deubiquitinase activity [GO:0004843] ALFVKLKSCRP;EDCGVFVALDKLEILE;QYIQDRSVG;SLPFSLTKMPNTN 4 5.6 1.0024 -0.99139 0 0 0 8.89184 0 0 0 0 0 0 0 0 0 12.0415 0 A0A8P0P0W7 A0A8P0P0W7_CANLF Transient receptor potential cation channel subfamily A member 1 TRPA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] LHHASLGG;PLHHAAEEGQV;QEIPNVDTSL;VENHTDDS 4 3.6 1.0035 -2.0853 0 0 0 0 0 0 0 8.60181 0 0 0 0 7.85953 0 8.55236 A0A8P0P0X5 A0A8P0P0X5_CANLF Fibroblast growth factor (FGF) FGF12 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] LNHNSGGRALEN;PLLLSGWRLVACFLK 2 8.1 0.99746 -0.10685 0 0 3.24076 0 0 0 11.0126 0 0 0 0 8.40591 0 3.60561 4.5568 A0A8P0P0Y4 A0A8P0P0Y4_CANLF Multiple PDZ domain crumbs cell polarity complex component MPDZ Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] AALLTRWQRIMG;ADLALVDTN;DEFDQLIKN;DVTKDMVLSPL;GVAAKDGRLKVGDQILAVDDE;LHMIELEKGRSGL;LLKTAKTT;LVPGGIAE;NAAYSNWNQPRRVEL;SGNKENYEKDEDSSSL;THQQAISILQKA 11 6.4 0.98138 -0.24889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.51428 A0A8P0P0Z8 A0A8P0P0Z8_CANLF Myomesin 2 MYOM2 Canis lupus familiaris (Dog) (Canis familiaris) AGISRPSRVSEAVAALDPVDLR;GSNAWEPCNHKPIGY;GVGRPSETS;LFKCEAWTM;LKSELAYEIFD;RVLSANKHGLS;SNHLQYLR 7 5.8 0.98879 -0.26122 0 10.2377 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P100 A0A8P0P100_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] YMTSHYSDP 1 3 1.0037 -0.80421 0 0 0 0 0 0 0 0 0 0 8.00388 0 0 0 0 A0A8P0P115 A0A8P0P115_CANLF Adhesion G protein-coupled receptor L2 ADGRL2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] carbohydrate binding [GO:0030246]; G protein-coupled receptor activity [GO:0004930] EIAYKDGVHELLLTVI;NESETGKNAIDYIYN;NPYTLRFEATWETV;QERFCEALDARG 4 4.1 0.98622 -0.42569 9.89005 0 0 0 0 0 0 13.8398 10.6711 0 13.8022 0 0 0 0 A0A8P0P116 A0A8P0P116_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SHPSDPWELLVS 1 6 0.94536 0.05044 0 0 0 8.53493 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P164 A0A8P0P164_CANLF LITAF domain-containing protein LITAFD Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872] QPGGAMGS 1 4.5 1.003 -1.1044 0 7.22081 0 0 6.25278 5.45421 0 0 0 0 6.31012 0 0 0 0 A0A8P0P165 A0A8P0P165_CANLF Voltage-dependent P/Q-type calcium channel subunit alpha CACNA1A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AKGGADKQQMDAEL;AQERPDHGRARA;DLLVTPHKS;DVEDEDSDEDEF;FIVVSGALVAFAFT;GAAAGVVV;GEGDGDGP;GGSRQGGQ;HYDNVLWALLTLFTVSTGEG;IKSLRVLRVLRPLKTIKRLPKL;ISVLRALRLLRI;ISVLRALRLLRIF;LGFAFHKGSYLRNGWNVM;LRVLRVLRPLKTIKRLP;MFIFAVVAVQLFKGKFFHCTDESKE;QLDPGGGLMAHEGGIKESPSWV;QYRMWQFV;RPLKTIKRLPKLKA;RVLRVLRPLKTIKRLPKL;SGSPAPST;SYLRNGWNVM;TDPCPVPA;TFEMVIKMIDL;TIKSLRVLRVLRPLKTIK;TVNRSLFLFSEDNVDD;VLHQGAYFRDLWNI;VLRPLKTIKRLPKLK;VLRVLRPLKTIKRLP;VLRVLRPLKTIKRLPKLK;VLRVLRPLKTIKRLPKLKA;VLRVLRPLKTIKRLPKLKAVF 31 11.2 0.99717 -3.5787 0 7.9431 12.3343 0 10.5684 3.37351 9.91997 10.4901 8.93637 10.1614 12.0238 8.32012 10.7565 8.42685 2.03872 A0A8P0P171 A0A8P0P171_CANLF DENN domain containing 2A DENND2A Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] ETYQDSPPRRSFLESLN;GESLGLRGRGDGML;KKKKIPKLV;KKKKIPKLVLRINAI;LCRPLDSRLEHVDFE;LNNLMLESKVDCFQ;NKGVMKVGGQDAEP;PQNGRKKKKIPKLVLRINAIYEAR;RKKKKIPKLVL;VYEDIVDP 10 9.2 0.93916 0.060882 6.63791 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P175 A0A8P0P175_CANLF Solute carrier organic anion transporter family member SLCO2A1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] LPAIFLISFV;LTTSSPCFTL;TTQDSRKET;VYPPRTSSPIH 4 6 1.004 -1.0857 0 0 0 0 0 0 11.2567 0 0 0 0 0 0 0 10.6236 A0A8P0P191 A0A8P0P191_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 7 ADAMTS7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GVQPCLSWYI;PDVGDLWTCSTTCGL;YWQRTNELSEDEEEA;YYDYNFINFHED;YYDYNFINFHEDLS 5 3.6 0.95142 0.053887 0 0 8.37352 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P1D2 A0A8P0P1D2_CANLF F-box protein 27 FBXO27 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GGDHGRLGFPGPASPGP;KWMVQHGGDGWVVEV;RPRRRALPPGPLLRAP;VPGLARPGGRPGPVAAHPGPRPRR 4 19.6 0.98705 -0.40792 11.2825 0 0 0 0 0 0 0 0 0 0 0 0 8.87517 7.24355 A0A8P0P1E1 A0A8P0P1E1_CANLF Tripartite motif containing 37 TRIM37 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] zinc ion binding [GO:0008270] DIDEETMSGENDV;KDRSSMENLWGLQ;MSSDSDIECDTENEEQEEHT;TQKSRDLSPPDNHL;VESSLLVGHPHPDA;VTTPVPPDFTSELVPSY;VVRGYYLSVFLEL 7 10.3 0.93617 0.060924 0 0 0 0 0 0 9.33139 0 0 0 0 0 0 0 0 A0A8P0P1F4 A0A8P0P1F4_CANLF Tensin 3 TNS3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] metal ion binding [GO:0046872] GVDPVYER;GVGPTPHLPDAQRPPPG;LDPQDRKWI;LRARPRRTLEEFTSL;VIFCALDP 5 3.4 0.9489 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.0071 A0A8P0P1F5 A0A8P0P1F5_CANLF TRAF3 interacting protein 1 TRAF3IP1 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] microtubule binding [GO:0008017] AEALQKEQSITDC;EGGKEKEKWKDRERERERDKARDRD;ICAVKANVL;KEDKRNSEINERSTSR;PEPAVKQKGDS;SKRRSKNSMEGRRDSRTSE 6 13 0.99288 -0.17478 0 0 0 0 0 8.10087 6.64101 0 0 0 0 0 0 0 0 A0A8P0P1G5 A0A8P0P1G5_CANLF Chloride channel protein CLCN7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] voltage-gated chloride channel activity [GO:0005247] ESPSFPDLPA;GVKIPHVVRLKTLVIK;KIFEYFRRDTEKR;PGLFQTVLPP;PHPFPKEIPHNE;TSLKRDFKIFEYFRRDTE;VLLKHKVFV 7 9.5 1.0021 -1.7972 0 0 0 3.81281 0 0 0 7.24031 11.304 5.72514 0 0 11.4231 0 0 A0A8P0P1H1 A0A8P0P1H1_CANLF Solute carrier family 37 member 4 SLC37A4 Canis lupus familiaris (Dog) (Canis familiaris) organelle membrane [GO:0031090] transmembrane transporter activity [GO:0022857] GLLLVGLVNIVFSW;TSHAIVGL;VGLMANVG;YYRTVIFSAMF 4 9.2 1.0026 -1.7683 0 0 0 0 0 0 0 8.88981 12.6142 0 0 0 0 0 0 A0A8P0P1I4 A0A8P0P1I4_CANLF poly(A)-specific ribonuclease (EC 3.1.13.4) CNOT6L Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; regulatory ncRNA-mediated gene silencing [GO:0031047] cytoplasm [GO:0005737]; nucleus [GO:0005634] exonuclease activity [GO:0004527]; metal ion binding [GO:0046872] DKYATRQLYGYCP;FFKTEKFTLVQ;LSNGGVAD;VLEVHKELFGTGVVEYLSNGGVADN 4 10.3 0.99193 -0.29197 0 0 0 0 0 11.0903 0 0 0 0 0 0 0 0 0 A0A8P0P1J2 A0A8P0P1J2_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] AIMSIEKIWAREIL 1 3.1 0.94459 0.061799 0 8.50391 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P1J9 A0A8P0P1J9_CANLF RAD18 E3 ubiquitin protein ligase RAD18 Canis lupus familiaris (Dog) (Canis familiaris) postreplication repair [GO:0006301]; protein monoubiquitination [GO:0006513] metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630] ERSEHFFKDQRD;KDSSAFLRCSCS 2 13.3 0.99081 -0.14596 9.8851 0 0 0 0 9.60492 0 0 0 0 0 0 0 0 0 A0A8P0P1K3 A0A8P0P1K3_CANLF Ral transcription factor IIIC subunit 1 GTF3C1 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] nucleus [GO:0005634]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677] DDHDQDDDEDEEVI;DGGLDEDDDEE;DTFSFKDEDNSKS;GGLDEDDDEEEDLDEGSG;HDQDDDEDEEV;HLNIPVCK;MDQEKQEGVSTKCCKKS;PLKKHTLIRFLPRSIRQQLLYKRR;VEEASWKRYVPPIPIHNEFGFGWA;VLELLQGLESL 10 6.3 0.98865 -0.30847 7.89869 3.1869 0 0 7.85854 0 5.94923 11.3146 0 4.36758 0 0 0 0 10.8262 A0A8P0P1M9 A0A8P0P1M9_CANLF PR domain zinc finger protein 10 (PR domain-containing protein 10) PRDM10 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] DPQTTSQQQPTQY;EDEDEDEDTEEDEEE;EDTEEDEEEDGEDTDLDDWE;HQSQQSTVDVGQ;LDKGDRKDRDLHEDL;PATSPHQSQQSTV;SESQPELEEKQASALSAG;VGQLHDPQTYT 8 9 1.004 -1.102 5.86126 11.2147 11.1879 0 5.84491 9.61774 0 0 9.62618 0 0 0 10.4165 0 0 A0A8P0P1N0 A0A8P0P1N0_CANLF Basic leucine zipper and W2 domains 1 BZW1 Canis lupus familiaris (Dog) (Canis familiaris) GGMLAPGGTL;VMSTVEWN 2 4.3 0.98768 -0.48216 0 0 0 0 0 0 0 0 0 7.67821 0 0 0 8.23587 0 A0A8P0P1N5 A0A8P0P1N5_CANLF Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] YTHIFDVP 1 2.6 0.98576 -0.25842 0 0 0 0 0 0 0 0 0 0 0 0 9.4439 0 8.12681 A0A8P0P1N7 A0A8P0P1N7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGHVSFCC;QPEDKADYYCGIQH 2 14.9 1.0039 -1.0433 0 0 9.57486 0 0 0 0 0 9.46848 0 0 0 0 0 0 A0A8P0P1N9 A0A8P0P1N9_CANLF Amino acid transporter SLC1A5 Canis lupus familiaris (Dog) (Canis familiaris) L-alpha-amino acid transmembrane transport [GO:1902475] melanosome [GO:0042470]; plasma membrane [GO:0005886] antiporter activity [GO:0015297]; metal ion binding [GO:0046872]; symporter activity [GO:0015293] EDPGATRGGRCGSRDRV;PLPVPTEE;TASSVGAAG;VGAAGIPA 4 6.9 1.003 -2.352 0 0 0 0 0 0 0 0 0 0 0 0 13.7144 0 0 A0A8P0P1P3 A0A8P0P1P3_CANLF Carboxypeptidase vitellogenic like CPVL Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type carboxypeptidase activity [GO:0004185] DQNYYGTF 1 1.7 1.0047 -1.1044 0 0 0 0 0 0 7.14354 0 0 0 0 0 0 0 0 A0A8P0P1Q8 A0A8P0P1Q8_CANLF SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) SAE1 Canis lupus familiaris (Dog) (Canis familiaris) protein modification by small protein conjugation [GO:0032446] nucleus [GO:0005634] ubiquitin-like modifier activating enzyme activity [GO:0008641] WCDLTSCQRLTSCQRIHIQ 1 5.2 0.95229 0.049882 8.51278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P1R8 A0A8P0P1R8_CANLF Fascin actin-bundling protein 1 FSCN1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674] AGKATKVGK;DGPEKGSGKS;DVPWGVDSLITLAFQDQRY;FLIVAHDDGRWS;FQLEIDRDTKKCAFRTHTGKY 5 12.9 1.0005 -0.93057 0 5.98718 0 0 6.58837 0 0 0 8.59485 0 0 0 7.69377 0 0 A0A8P0P1S3 A0A8P0P1S3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EPLPISTFQGDPL;LVLRHPLLVLLEVLALPRLQVEP;VLSELRPDVFAQ 3 14.2 0.98658 -0.39285 0 0 0 0 0 0 0 8.53314 0 0 0 0 0 9.19655 9.85594 A0A8P0P1S7 A0A8P0P1S7_CANLF protein disulfide-isomerase (EC 5.3.4.1) P4HB Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] protein disulfide isomerase activity [GO:0003756] DDDDLEDLEEAEEPDLEEEDDQKTV;KGKILFIFI;LLDFIKHNQLPLVI 3 10.3 1.0014 -0.70779 8.27687 0 0 0 0 0 0 0 6.40562 0 0 5.78437 0 0 0 A0A8P0P1T4 A0A8P0P1T4_CANLF "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II)" CPT2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] mitochondrial inner membrane [GO:0005743] acyltransferase activity [GO:0016746] FNPFMAFNPDPKSEYNDQLIRA;LSSSTVNIGGF;SYISGPWFDMY;TVNIGGFAPVVP 4 7.9 0.99094 -0.13564 0 7.74147 9.74391 0 0 0 8.43879 0 0 0 4.41386 0 5.78521 0 0 A0A8P0P1V1 A0A8P0P1V1_CANLF A-kinase anchoring protein 9 AKAP9 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090] AEIHCLQERLQ;AINELNIKLQ;DRRSLLSEIQAL;DRTRNWVLQQKIE;DTLASEQKKSREL;ELLEKQMKEKEDDLQ;GVMTITSKD;KALEIDVEE;LNEVIEKLQQELANIEQK;LSASQMTSLQDIDIDSEK;NDKLQWELSVLKSEQNDLR;PESEISTT;QNEMSQKIETMQF;REQENDQPNQEL;SETETLKREHYVA;TEKSTNLLREE;TSLILEKERVEIVE;VEQLTNHLKEKTD;VLLESEKVRIQEMSST;VTEEYNKLLV;VTPESALIKRDEVFSVE 21 7.3 0.97125 0.048313 0 0 0 0 0 0 0 0 0 0 6.90183 0 0 0 7.51916 A0A8P0P1V2 A0A8P0P1V2_CANLF Programmed cell death 11 PDCD11 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] nucleic acid binding [GO:0003676] DPEINSIQDIQ;EGQTVVAKVTNVDEE;MSVLPKEKPRRPAEVPRLQ;PNKEHVDV;PSIIESQYFRY;TSPTAKLK;TTSLLLLSQ;VPKHELSAEYVPDP 8 5.2 1.0038 -1.037 0 0 0 0 0 10.924 5.06574 10.4467 0 0 8.93537 8.01184 0 0 0 A0A8P0P1V5 A0A8P0P1V5_CANLF UBA domain-containing protein DDI2 Canis lupus familiaris (Dog) (Canis familiaris) LPLQDLSN;NALNDQEHLCS;TTSLGMSS 3 3.8 1.0022 -1.8652 0 0 0 0 0 0 0 0 0 0 11.5856 0 0 0 0 A0A8P0P1W4 A0A8P0P1W4_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" AGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] FVNSQEWTL;PAPLLPAKAPV;QSCESSKNKSRLTSQSE;RPDGMQQRSYSV;SLQSCESSKNKSRLTSQ;YHYYSRMANYRNTSEIPLVLVGTQ 6 8.5 0.98687 -0.38405 0 0 7.89184 0 8.18527 0 0 10.3775 10.1544 0 0 0 0 0 0 A0A8P0P1W6 A0A8P0P1W6_CANLF Maltase-glucoamylase MGAM Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DVVKTNAGF;ELFWDDGETKGEIEHLRD;EQVVQEYLELIGR;GDVVKTNAGF;GYILPWQEPAQNTHLRGFKWSHK;HTWGMFSR;IIGMMEFSLF;ITPVLDEGAEKVMAYIPD;LVSPVLEPVSVFS;PVNYKGFP 10 7.2 0.98735 -0.35416 0 0 0 9.87598 0 0 0 16.6492 0 0 0 0 9.59477 0 7.31506 A0A8P0P1X8 A0A8P0P1X8_CANLF E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR) CHFR Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] nucleus [GO:0005634] metal ion binding [GO:0046872]; transferase activity [GO:0016740] AICTCCFQPMPDRRA;AVKPDKMEET;DLLHDCVSLQP;SSSGGDPD;VSLEDTSTNGT;YRRQGGQALPCPGP 6 11.4 1.0026 -1.7459 0 7.5157 4.28281 0 0 0 0 0 0 8.08905 0 0 0 9.96636 0 A0A8P0P205 A0A8P0P205_CANLF Aryl hydrocarbon receptor AHR Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; rhythmic process [GO:0048511]; xenobiotic metabolic process [GO:0006805]" cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983] DFSGEDDFRDIDITDEI;QQQQQQLLQHHQN;VLNETYPAELSNINN 3 5.3 0.99475 -0.083813 13.3614 13.587 0 0 0 11.2965 0 9.54011 0 0 0 0 0 13.5035 0 A0A8P0P212 A0A8P0P212_CANLF Glycosyltransferase 6 domain containing 1 LOC100682797 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758] GDFYYHSAIFGGTPGE;RDHEAEEPQLSDW 2 9.4 0.99249 -0.19299 0 0 0 0 0 6.21828 0 0 10.5394 0 0 0 0 0 0 A0A8P0P217 A0A8P0P217_CANLF PX domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768] phosphatidylinositol binding [GO:0035091] VNLNDAYGPPSNFLEIHVSNLQ 1 18.3 0.98944 -0.26543 0 0 0 8.97656 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P224 A0A8P0P224_CANLF Ribosomal protein L37a RPL37A Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] structural constituent of ribosome [GO:0003735] CGKVGAGG;VERPVEAPPC 2 11.4 1.0032 -0.87738 0 0 0 8.39056 0 0 0 0 0 0 0 0 9.39838 0 0 A0A8P0P233 A0A8P0P233_CANLF Protein kinase C and casein kinase substrate in neurons 1 PACSIN1 Canis lupus familiaris (Dog) (Canis familiaris) actin filament organization [GO:0007015]; neuron development [GO:0048666]; plasma membrane tubulation [GO:0097320] ASLMPPSGQMMRVG;KRWRQLIEKGPQ;VFEQCQQFE 3 6.9 1.0022 -0.90277 0 11.2173 0 0 0 3.30337 0 0 0 0 0 0 0 0 0 A0A8P0P235 A0A8P0P235_CANLF Tenascin R TNR Canis lupus familiaris (Dog) (Canis familiaris) GVCVDGQCVCDSEYSGGDCSEL;HGTVTSEPIVGS;NINVPLDSLCSSGL;NISVYAVISNILSLPI;RCPGDCSG 5 6.3 0.98732 -0.33739 0 0 0 0 0 0 0 0 0 8.33798 0 0 0 9.72381 0 A0A8P0P255 A0A8P0P255_CANLF Zinc finger protein 200 ZNF200 Canis lupus familiaris (Dog) (Canis familiaris) HKERLNTSVPK;PLCGKQFNDSSYL 2 8.4 0.92334 0.095331 0 0 5.87029 0 0 0 0 0 0 0 0 0 9.02639 0 0 A0A8P0P258 A0A8P0P258_CANLF Follicular dendritic cell secreted protein Canis lupus familiaris (Dog) (Canis familiaris) QEREQRSVSG 1 12.5 0.99126 -0.14483 0 0 0 0 0 0 0 0 0 0 10.4844 0 0 0 0 A0A8P0P271 A0A8P0P271_CANLF E3 ubiquitin-protein ligase RNF8 (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8) CMTR1 RNF8 Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine mRNA capping [GO:0006370]; cell division [GO:0051301]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; methylation [GO:0032259]; positive regulation of DNA repair [GO:0045739]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]" chromatin binding [GO:0003682]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842] HEFTDYMIRSNES;TDRKGVHF;VTEEDWERMYPCLAP;YPCLAPKNDQ 4 3.1 1.0023 -1.1707 8.54628 0 11.7641 0 8.36374 0 0 7.76095 6.89651 0 0 0 0 0 12.5637 A0A8P0P276 A0A8P0P276_CANLF "SEC24 homolog C, COPII coat complex component" SEC24C Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] LPVLDNPLSKKVR;PPSSEAPPASTAQAPC;TSPASGGP 3 3.5 1.0036 -1.6055 0 0 0 0 0 0 0 11.4756 0 9.79867 0 0 0 0 0 A0A8P0P277 A0A8P0P277_CANLF C-C motif chemokine CCL19 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] SPTHSPAL 1 8.9 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.3937 A0A8P0P2A2 A0A8P0P2A2_CANLF Mevalonate kinase (MK) (EC 2.7.1.36) MVK Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695]; isoprenoid biosynthetic process [GO:0008299] cytoplasm [GO:0005737] ATP binding [GO:0005524]; mevalonate kinase activity [GO:0004496] EVAGIPKDGADPE;LEQPKVEAMKQAL;VLLVSAPG 3 9.8 0.99796 -0.10362 0 0 0 8.2948 0 0 0 8.18249 0 0 0 0 10.2473 9.16453 0 A0A8P0P2C6 A0A8P0P2C6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LQAEDEADYYCSTYDS;RYNVNWYQ;SSNISRYNVNWYQQL;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 35.9 0.98687 -0.39743 0 5.72197 0 0 0 7.13761 0 0 0 0 0 0 0 0 0 A0A8P0P2C8 A0A8P0P2C8_CANLF Solute carrier family 8 member B1 SLC8B1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816] membrane [GO:0016020] antiporter activity [GO:0015297] HGREAGARWTVGV;SEEYRPLLFYQETTA;TVGVGLGG;VVAGGIAI 4 6.2 0.9912 -0.2061 0 0 0 9.35387 0 0 0 0 0 12.5534 0 0 0 0 0 A0A8P0P2D2 A0A8P0P2D2_CANLF Nitric oxide associated 1 NOA1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525] AEENLSPQEQ;DEAAFEFDADSLA;MGGEERMAGFPPLVGE;PSCLVRGLSRGSAAPG;VQMSREQYL 5 9.8 1.0025 -0.79158 0 9.03191 14.6972 0 8.6962 0 0 0 0 0 0 0 0 0 10.0493 A0A8P0P2D9 A0A8P0P2D9_CANLF Cytochrome c oxidase assembly factor 1 COA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RHFIQYNGV 1 4.7 1.0035 -0.80421 0 0 9.76303 0 0 0 3.64305 0 0 0 0 0 0 0 3.61542 A0A8P0P2E0 A0A8P0P2E0_CANLF Dynamin-binding protein (Scaffold protein Tuba) DNMBP Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] anchoring junction [GO:0070161]; Golgi stack [GO:0005795]; synapse [GO:0045202] guanyl-nucleotide exchange factor activity [GO:0005085] AENKGYDTLFTNYESKFQN;DPDSSPQPRSW;DPEEAEENGEDYMDYG;TQIPNIDFEG 4 4.6 0.93529 0.098764 9.33367 0 0 0 0 0 0 0 0 2.96407 0 0 0 0 0 A0A8P0P2I1 A0A8P0P2I1_CANLF Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; lateral plasma membrane [GO:0016328]; membrane raft [GO:0045121]; voltage-gated potassium channel complex [GO:0008076] calmodulin binding [GO:0005516]; voltage-gated potassium channel activity [GO:0005249] FSSYFVYLAE;RPLERKRRPQQSTWAF 2 3.8 0.9601 0.049233 0 7.42987 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P2I9 A0A8P0P2I9_CANLF NLR family pyrin domain containing 6 NLRP6 Canis lupus familiaris (Dog) (Canis familiaris) IPWGRLDGLDAMDL;KKKYFHKFFRD 2 3 0.93224 0.096373 0 0 0 3.35699 0 0 0 2.90277 0 0 0 0 0 2.7994 0 A0A8P0P2J8 A0A8P0P2J8_CANLF Autophagy and beclin 1 regulator 1 AMBRA1 Canis lupus familiaris (Dog) (Canis familiaris) AFIPSSQRGFPDEGIL;ELVEDKTRWMKW;HELQCDLRRFFLE;RRLSPAAYYAQRMIQ;WERIYTQSSRSGTVS 5 5.4 0.98752 -0.40352 0 8.65424 0 0 0 3.34412 0 0 0 0 0 0 0 0 7.62564 A0A8P0P2K3 A0A8P0P2K3_CANLF Zinc finger and SCAN domain containing 20 ZSCAN20 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EQMRPAQASAWRDS;EQWEECSSE;PGQSSTEADDQQAWDEMADE;QWVKNSCPDLPK;RPGQSSTEADDQQAWDEMAD;RSNLITHQR;TGEKPYKCGECWKSFN;VQEPRIPGGPTLFQSRIGVHW 8 9 1.0035 -1.965 0 0 8.72561 8.60366 9.78372 0 0 11.0916 0 0 9.60874 0 7.51554 0 0 A0A8P0P2K6 A0A8P0P2K6_CANLF Chromosome 27 C12orf40 homolog REDIC1 C27H12orf40 Canis lupus familiaris (Dog) (Canis familiaris) DQQRIRKTFDKCDCD;GGGTSSLK;MDEQRQSDFITEK;NCILQVARCDAW 4 8.1 1.0015 -0.94045 0 0 0 0 0 5.81373 0 0 0 10.2657 4.76945 0 0 8.77686 0 A0A8P0P2L7 A0A8P0P2L7_CANLF 2'-5' oligoadenylate synthase (EC 2.7.7.84) OAS2 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087] cytoplasm [GO:0005737] nucleotidyltransferase activity [GO:0016779] AEGFRTVLEL 1 1.5 0.99971 -0.61146 0 8.47431 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P2N1 A0A8P0P2N1_CANLF Basal cell adhesion molecule BCAM Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SKTLELRVAYLDPLEL 1 2.8 0.96172 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.58292 A0A8P0P2P3 A0A8P0P2P3_CANLF Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] ASMIFRKEPFFHGHDNYDQVINIV;ESHVVEWGNQ;ILKPVKKKKIKREIKILE;ILKPVKKKKIKREIKILENLRG;KILKPVKKKKIK;KILKPVKKKKIKREIKILE;KVVVKILKPVKKKK;KVVVKILKPVKKKKI;KVVVKILKPVKKKKIK;KVVVKILKPVKKKKIKR;LKPVKKKKIKREIKILENL;NEKVVVKILKPVKKKKIK;PVKKKKIKREIKILEN;TDFKQLYQTLTDYDIRFYMYEILK;VKILKPVKKKKI;VKKKKIKREIKILENL;VVKILKPVKKKKIK;VVKILKPVKKKKIKREIKI;VVKILKPVKKKKIKREIKIL;VVVKILKPVKKK;VVVKILKPVKKKK;VVVKILKPVKKKKI;VVVKILKPVKKKKIKR;VVVKILKPVKKKKIKREI 24 34.1 0.99192 -0.29121 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9983 A0A8P0P2P9 A0A8P0P2P9_CANLF GABA type A receptor associated protein like 2 GABARAPL2 Canis lupus familiaris (Dog) (Canis familiaris) DHSLEHRCVESAK 1 31.7 0.98942 -0.21597 0 0 0 0 0 0 0 0 0 0 9.37236 0 0 0 0 A0A8P0P2Q9 A0A8P0P2Q9_CANLF 2-oxoglutarate and iron dependent oxygenase domain containing 3 OGFOD3 Canis lupus familiaris (Dog) (Canis familiaris) "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" STEARTAHDEYWH;VGKHFVNLY 2 7 0.93764 0.05984 0 0 0 0 0 0 0 9.13417 0 0 0 0 0 0 0 A0A8P0P2S2 A0A8P0P2S2_CANLF SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) Canis lupus familiaris (Dog) (Canis familiaris) WRPALLIKQILL 1 12.2 0.94252 0.05044 0 0 0 0 3.93555 0 0 0 0 0 0 0 0 0 0 A0A8P0P2S6 A0A8P0P2S6_CANLF Latent transforming growth factor beta binding protein 1 LTBP1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DINECLEDNSVCQGGDC;GFNKCQKCPKKPSYHGYN;HGPGVAEPEV;INTEGSYDCTCPDGFQLND;ISEEKGPCYRLVSSGRQCMH;LMCLLFFFSL;QPGYECYCKQ;SISADGHTCE;SLDQEKTKLEPGQPQL;TTYTECCCLYGEA 10 10.6 0.98775 -0.23425 0 0 0 0 0 0 0 0 0 12.3661 0 0 0 0 0 A0A8P0P2U2 A0A8P0P2U2_CANLF Mpv17-like protein 2 MPV17L2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] LMAAGDGV;TAGGWGAG;VPLLPCCVLGKKRQGSGVSHH;VVGCGDGP 4 13.4 1.003 -2.4258 0 0 0 0 0 12.7371 0 10.7222 0 8.41578 0 8.9888 0 0 0 A0A8P0P2U5 A0A8P0P2U5_CANLF T-complex protein 1 subunit beta (CCT-beta) LOC100686930 Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] AIEHTDFAGV;IHVIKKLGGINQPKRI;MESYAKALRM;VLDMKEGTIGDMAVL 4 11.5 1.0021 -0.98866 0 0 0 0 0 0 0 0 0 5.6138 9.57769 0 10.6145 0 0 A0A8P0P2W5 A0A8P0P2W5_CANLF F-box protein 33 FBXO33 Canis lupus familiaris (Dog) (Canis familiaris) DLKVLEVTEESI;RAGAARVARWRRLR 2 5 0.99492 -0.083799 10.7383 0 0 0 0 3.92477 0 0 0 0 2.98961 0 0 0 0 A0A8P0P2W6 A0A8P0P2W6_CANLF Golgin A1 GOLGA1 Canis lupus familiaris (Dog) (Canis familiaris) ELEARTRELSHTREE;KLEQENAALRESKNECER 2 4.7 0.99061 -0.1353 0 8.79386 4.53959 0 4.51835 4.33178 7.62183 0 0 4.205 0 0 4.22458 0 0 A0A8P0P2X1 A0A8P0P2X1_CANLF Unk zinc finger UNK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] CHTRTEQQFHPEIYK;DEWGDPGKCENGD;ISAYDNRYLKEFRTEQCPLFVQH;SPAGTSSVP;VGSPLTSSISSS 5 9.1 1.0021 -0.96857 0 0 0 9.19249 0 8.63496 0 0 0 0 7.72376 4.70957 0 0 0 A0A8P0P2Y1 A0A8P0P2Y1_CANLF Olfactory receptor OR7G10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EDPELLPLLFGL;PRRRAAASV;SYTRIVSSI;VGSDSHLHTPM 4 13.1 1.0037 -1.0419 0 0 0 0 0 0 6.65292 0 0 0 0 8.24136 0 0 8.04188 A0A8P0P302 A0A8P0P302_CANLF DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) MCM8 CRLS1 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508] chromosome [GO:0005694]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] IQVVDFENFIGS;QALLEAMEQQSISLAKAGM;SRMRWSPGCGGC;TRRIDLYDKDEIERKG;VGGHYNKAKTVSENLKMGS 5 7.4 0.98648 -0.32991 0 0 0 0 0 0 0 9.7704 9.6639 4.19834 0 0 0 7.22997 0 A0A8P0P308 A0A8P0P308_CANLF DnaJ heat shock protein family (Hsp40) member C8 DNAJC8 Canis lupus familiaris (Dog) (Canis familiaris) QDDADRAQKAFEAVDKAYK;VKERKKQLKKEG 2 13.2 0.94089 0.10018 0 0 0 0 0 0 0 6.62956 0 6.25533 0 5.6318 0 0 0 A0A8P0P315 A0A8P0P315_CANLF Ceramide synthase 6 CERS6 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] EGPAGAGGGV;GVRFLKKTPWLWNTRHCWYNYP;LTTDLHYYYIL;VLNTTLFESWEIVG 4 9.3 0.99921 -0.61146 0 0 0 0 0 0 0 0 0 7.58459 0 0 0 0 0 A0A8P0P317 A0A8P0P317_CANLF Zinc finger protein 81 ZNF81 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DCGKGFTQK;KSHLFAPQRI;TGERQHKCGE;TSISKRTG 4 5.3 1.0026 -1.4844 0 0 12.0708 0 0 0 0 11.8591 0 0 0 12.268 0 0 0 A0A8P0P320 A0A8P0P320_CANLF Class II major histocompatibility complex transactivator CIITA Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] ATP binding [GO:0005524] AGFSAQQAETYMT;LTPRKKRPY 2 2.1 1.0013 -0.74465 0 3.89947 0 9.05474 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P321 A0A8P0P321_CANLF Chaperonin containing TCP1 subunit 6B CCT6B Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] IDLFMVEIME;SESKQPVGIDLNTG 2 5.2 0.99411 -0.026588 7.83276 0 11.7004 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P341 A0A8P0P341_CANLF Cellular communication network factor 2 CCN2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] extracellular region [GO:0005576] CCEEWVCDEPKD;LPAPARPLRPAKDGAPCV;PRPRLRKPGPPPPRPEPATQ 3 12.6 0.99473 -0.15647 8.20491 8.31515 0 0 0 0 0 8.95388 0 4.36996 0 0 0 0 0 A0A8P0P355 A0A8P0P355_CANLF "55 kDa erythrocyte membrane protein (Membrane protein, palmitoylated 1)" MPP1 Canis lupus familiaris (Dog) (Canis familiaris) stereocilium [GO:0032420] GSMRTALSDLYLE;RLRRLRRPAGLGARSPGSAPLA;VIPNQQNRLPALQMFMRAQ 3 8.1 0.84906 0.15644 0 0 0 0 5.55992 0 0 8.78519 0 0 0 0 10.8124 0 0 A0A8P0P359 A0A8P0P359_CANLF Membrane spanning 4-domains A4A LOC102155749 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VTAPYEHVYEELE 1 6.1 0.98941 -0.19729 0 0 0 0 0 0 7.69592 0 0 0 0 0 0 0 0 A0A8P0P364 A0A8P0P364_CANLF Cellular communication network factor 5 CCN5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] GATWGRSH 1 3.2 0.99026 -0.26592 9.68977 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P384 A0A8P0P384_CANLF Histidyl-tRNA synthetase Canis lupus familiaris (Dog) (Canis familiaris) EQRLEATEEKVWTTETQV 1 8 0.97119 0.048313 0 8.44717 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P387 A0A8P0P387_CANLF Adenylate kinase 5 AK5 Canis lupus familiaris (Dog) (Canis familiaris) ATP metabolic process [GO:0046034] cytoplasm [GO:0005737] adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524] EDQGDDQLN;KVNAEGTPEEVFLQLC;LSFEDQICTPDLVV 3 7.7 0.95539 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 9.16855 0 A0A8P0P388 A0A8P0P388_CANLF NBAS subunit of NRZ tethering complex NBAS Canis lupus familiaris (Dog) (Canis familiaris) "protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" endoplasmic reticulum [GO:0005783] AKNKKEKKIKKRRELLKL;DEGEEDSDSDQEVSAKARYFGY;ESCGCADF;ETRGGDEDEGE;FETLKTDPEAFHKHMVKYIY;GVKILPLQVRLRGDRIS;IKPETHIRLLKKFKVV;LFTYHGSDLLP;LGLAETLEESVY;LGLLRMLSIKFYSRPGQEQDGI;LPQVLDANK;LSIWAIPS;LVSLKNSEQEIL;MMHCSACS;QDGIFKMSLSPDG;VLREELVSSE 16 8.9 0.99686 -4.4272 12.6882 9.89648 10.2184 1.99548 8.98411 9.07339 3.86513 0 9.33742 8.49645 0 8.90379 0 0 8.32085 A0A8P0P399 A0A8P0P399_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) VRK1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DILEYIHEHE;RGDLEILGYCMIQWL;TQTKEATQTRSKTRKR;VEPSDNGPLFTELKFYQ 4 14.8 0.99691 -0.099105 0 5.77481 0 0 7.50303 0 0 9.44944 0 0 0 0 10.7136 0 0 A0A8P0P3B1 A0A8P0P3B1_CANLF EGF like repeats and discoidin domains 3 EDIL3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CECPDGFTDPNCSSVVEVGPCVP;VCLSGLSDNSFSCECPDG 2 7.6 0.92925 0.094592 5.21156 0 0 0 5.35106 0 0 0 0 0 0 0 0 0 0 A0A8P0P3D6 A0A8P0P3D6_CANLF Mucolipin 2 MCOLN2 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] ECLREDLK 1 1.5 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 9.05009 0 0 0 A0A8P0P3D8 A0A8P0P3D8_CANLF Solute carrier family 9 member C2 (putative) SLC9C2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sodium:proton antiporter activity [GO:0015385] MVYMTFYIGESFG;WADARLALKKYIAKV 2 5.5 0.9511 0.053874 0 0 0 0 0 0 0 0 0 3.68471 0 0 0 0 0 A0A8P0P3F7 A0A8P0P3F7_CANLF "Golgi associated, gamma adaptin ear containing, ARF binding protein 3" GGA3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] early endosome membrane [GO:0031901]; trans-Golgi network [GO:0005802] phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130] GSSSSVLAPAPPSSGI;QEWEAVQALTYLGDRVSEKVK 2 5.3 0.97733 0.047846 0 0 0 0 0 0 0 0 0 0 0 0 0 8.7848 0 A0A8P0P3G1 A0A8P0P3G1_CANLF Protein SEC13 homolog SEC13 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] lysosomal membrane [GO:0005765]; nuclear pore [GO:0005643] structural molecule activity [GO:0005198] KEEQKLEAH 1 3.2 0.99416 -0.073197 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3529 0 A0A8P0P3G7 A0A8P0P3G7_CANLF Ataxin 7 like 1 ATXN7L1 Canis lupus familiaris (Dog) (Canis familiaris) LAGDLSLASHNAVSSL;PASVSQPFNNP;SALNSYQAAPPYNS;SGSSGPEPKVASPAKSRPPN;VSTLESVAPRCPLSLAAQTPG 5 8.7 0.68015 0.29385 11.4059 8.62212 11.509 9.5173 9.61482 9.69853 0 11.3061 0 11.423 11.5594 11.8792 0 0 9.31965 A0A8P0P3H2 A0A8P0P3H2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] AAEPPRSRGLTPAD;AAGGGGGG;EDDTSYFDTRSEKYHHM;FPSGTNSSQSSSPSSS;GGGGGGGA;GGGGGGGG;GGRGGGGG;ITSRYFLELQHKLDKLLQ;KYHHMETEEEDDTNDED;LLECLEFDPE;LLQEAHDRSE;PPPPAAQELPGP;TLSDMFAVSPLGSPM;TPVPPAPP;VGTPVPPA 15 6.2 0.95295 0.053902 0 0 0 0 0 0 0 0 0 0 0 0 8.60748 0 0 A0A8P0P3I5 A0A8P0P3I5_CANLF Monoamine oxidase B MAOB Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] oxidoreductase activity [GO:0016491] EAGERAAREILH;PLPMMRNQLITRVP;WCEEQYSGGCYTTYFPPGIMTQYG 3 10.5 0.99045 -0.21203 0 0 0 0 0 0 7.74799 0 0 0 0 0 0 6.92884 0 A0A8P0P3I7 A0A8P0P3I7_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]" AAAALYPG;APRVFTDSGERRRQQN;GVPVISLGHTRPPG;SPVPGLPP 4 18.5 1.0019 -1.2602 0 8.53559 7.01647 6.78175 0 6.71891 0 4.45648 0 9.76722 0 8.83898 7.57554 5.76245 7.62753 A0A8P0P3J0 A0A8P0P3J0_CANLF Elongation factor 1-alpha Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] ENIVHRSGKKLE 1 2.6 0.94324 0.05044 0 0 0 0 0 0 0 0 7.77604 0 0 0 0 0 0 A0A8P0P3K3 A0A8P0P3K3_CANLF Fanconi-associated nuclease (EC 3.1.4.1) FAN1 Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518] HSAPAESLRAWVA;ILKRAKALAGQSLRVC;KNEITCRITSEQ;YTRILSRTVEILQRL 4 5.7 0.99774 -0.089439 0 9.09326 0 0 0 0 7.93516 0 0 8.64227 0 0 0 7.72192 5.99263 A0A8P0P3N8 A0A8P0P3N8_CANLF Cadherin domain-containing protein LOC478038 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DRNDNAPQVL;LLKKAGAA 2 1.9 1.0026 -0.71487 7.66959 7.2891 0 0 0 0 7.19377 7.0608 7.02326 7.92588 7.52583 7.88935 8.39648 8.30296 10.2772 A0A8P0P3N9 A0A8P0P3N9_CANLF BEN domain containing 2 BEND2 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] DNSDDDDDI;EDNSDDDDDI;FILIEMPE;HYKGAGGPS;IEDNSDDDDD;KIVSTYSLQHSLSPESSVAPLAM;PESSVAPLAMSCFVSGGVE;RESPPLPKIV 8 7.1 0.99732 -3.8527 0 5.14547 0 0 7.90219 8.59988 0 0 0 0 0 7.67299 0 8.89321 6.20727 A0A8P0P3P0 A0A8P0P3P0_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" VIYDYFGI;VIYDYFGIMEDL 2 13.6 0.99235 -0.19301 0 0 0 0 9.46599 9.85868 0 0 0 0 0 0 0 0 0 A0A8P0P3P1 A0A8P0P3P1_CANLF Leucine rich repeat and fibronectin type III domain containing 2 LRFN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HNLLDHIAEG;RVKMYQLQYNCSDDEVLIYRMIP;SLHLDSNRLPSL;TSRGGGGS 4 6.7 1.0015 -1.8084 0 0 15.1755 0 0 11.8006 15.9494 0 0 0 10.3197 0 0 0 0 A0A8P0P3P7 A0A8P0P3P7_CANLF Proline rich transmembrane protein 2 PRRT2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DFSSCWELPW;GEGTQKPRDYIILAI;LQPGPDITGAPVDSEAKAG;TETPTGVPETAQARDLSSNP 4 15.7 0.9859 -0.45176 0 8.74712 6.83137 0 0 0 0 0 0 0 9.26697 0 6.20434 0 0 A0A8P0P3Q4 A0A8P0P3Q4_CANLF EH domain binding protein 1 EHBP1 Canis lupus familiaris (Dog) (Canis familiaris) IENESPSGRRK;LASLMSMKQADIGNL;LFKDPHAEEFEDKEW;QEKQAEEEDEH;SGVKMSELP 5 5.3 0.98708 -0.3645 0 6.12805 12.2637 0 0 0 0 0 0 0 0 0 5.76951 13.7728 0 A0A8P0P3Q7 A0A8P0P3Q7_CANLF Nuclear pore complex protein Nup93 NUP93 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; protein transport [GO:0015031] nuclear membrane [GO:0031965]; nuclear pore [GO:0005643] structural constituent of nuclear pore [GO:0017056] DITDNQSEVADKTEDY;GLQDGEVEGHP;LEQSYKNYT;RPQRVIEDRDSQLRSQ;VALVLFELKLLL 5 7.8 0.99082 -0.14672 0 7.28854 6.77716 0 0 0 0 7.98271 0 9.02782 0 0 0 5.84046 7.03474 A0A8P0P3S6 A0A8P0P3S6_CANLF Angiogenic factor with G-patch and FHA domains 1 AGGF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676] AAEAAVSQTGFSYDENTGL;LKKKRKDPDSSL;PRRRPAPSERPRPRPRPRPRPRPRR;SEDEADEEKIWPPC;SPPKFTVSVSGKTTES;YQTYYKDVSLPNKVTELSVQQ 6 12.5 0.66284 0.30656 0 8.91238 0 8.88108 0 8.15932 0 0 6.96636 0 0 0 0 9.67021 9.53864 A0A8P0P3U8 A0A8P0P3U8_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK5 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] GVGPGMPQAQVL;LNEKQILEKVN;LNEKQILEKVNSQFVVN 3 4.8 0.98974 -0.26403 0 0 0 0 0 8.35398 0 0 0 0 0 0 0 0 0 A0A8P0P3V1 A0A8P0P3V1_CANLF Epidermal growth factor receptor pathway substrate 15 like 1 EPS15L1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] EAHWAVRVEEKA;GAVPVLPA;KEEAIRQKSNE;LDEMDQQKAKLRDM;PLSQQVDP;TSDPFTKNPSL 6 7 1.0034 -1.1044 0 0 0 0 0 8.5678 0 0 0 0 0 0 0 0 0 A0A8P0P3W5 A0A8P0P3W5_CANLF Cytochrome P450 family 24 subfamily A member 1 CYP24A1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] mitochondrial inner membrane [GO:0005743] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" HDTLAEYHKKYGKIFR 1 3.6 0.9606 0.049233 0 0 0 0 0 0 0 0 0 0 0 6.44148 0 0 0 A0A8P0P3W6 A0A8P0P3W6_CANLF Cadherin 8 CDH8 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KDTATVKIVVEDADEPPVFSS;PERLAGMPLDLW 2 4.3 0.9444 0.10057 0 0 9.87181 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P3X4 A0A8P0P3X4_CANLF Sterile alpha motif domain containing 11 SAMD11 Canis lupus familiaris (Dog) (Canis familiaris) ELTPSFSASD;LTEEHLLTTMGLKLGPA;MGLKLGPALKIRAQVAKRLGRVFY;SSAPLLALPPQGPPGPGPPT 4 10.4 0.97268 0.041303 0 0 0 0 0 0 0 0 0 0 0 4.82599 0 0 0 A0A8P0P3X9 A0A8P0P3X9_CANLF Transcription termination factor 2 TTF2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] DGPHATWKIISKAIDELH;EAHCVRNPRV;LAWLLWRESQ;LTWLSKDD;QQRGEKTELQ 5 5.2 1.0031 -1.921 0 0 0 8.24821 0 0 0 10.7284 0 0 6.7909 0 10.2807 0 8.4765 A0A8P0P3Y7 A0A8P0P3Y7_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" AGAP3 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] FVNSQEWTL;LALDRSNTQLGGGTGA;QPRTRPSSSLQG 3 4.1 0.95344 0.05044 0 0 0 0 0 0 6.21539 0 0 0 0 0 0 0 0 A0A8P0P419 A0A8P0P419_CANLF Chloride intracellular channel protein Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886] chloride channel activity [GO:0005254] EGDETSAENEGI;QKLCPGGQL 2 8.7 0.95175 0.05044 0 0 0 0 0 0 0 0 0 0 7.44427 0 0 0 0 A0A8P0P428 A0A8P0P428_CANLF Laminin G domain-containing protein CSPG4B Canis lupus familiaris (Dog) (Canis familiaris) DDSETQCDEF;EEMPLHGFLQ;EIKVAISVELRN;EVQNFTVQEGGSKTLLE;EYLHPSEVPLS;IFVHTGMSW;MKVDVASEDLGIHHSQ;VHWLKVILLKNV;VSPALGMEKAF;WRVQGEGL 10 7.9 0.99531 -0.11716 0 0 0 0 0 0 0 11.5751 0 0 0 0 0 0 0 A0A8P0P434 A0A8P0P434_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLRFHGKPN 1 3.5 1.0034 -0.80421 0 0 0 0 0 0 0 8.75425 0 0 0 0 0 0 0 A0A8P0P453 A0A8P0P453_CANLF Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (Prostaglandin H2 synthase 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516]; response to oxidative stress [GO:0006979] endoplasmic reticulum [GO:0005783] dioxygenase activity [GO:0051213]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] AQFQYRNRIAMEFNQLYH;LLLLLLLL;LLLLLLLLL;LLLLLLLLP;LLLLLLLP;LTGEKEMAAELEELYGDI;LYHWHPLMPDSFWV;NSLRPSPS;PLLLLLLLLL;RLHRWPLLLLLLLLLPPPPVL;RRFLLRRKFIPDPQG 11 16.4 0.93666 0.069155 0 0 0 0 0 0 11.8554 9.53494 10.809 0 5.02445 0 0 0 0 A0A8P0P464 A0A8P0P464_CANLF Eukaryotic initiation factor 4A-I (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] INYDLPTNKENYI 1 4.6 0.94478 0.059664 0 0 0 0 0 0 0 7.97292 0 0 0 0 0 0 0 A0A8P0P491 A0A8P0P491_CANLF Tubulin--tyrosine ligase-like protein 9 TTLL9 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] ATP binding [GO:0005524]; ligase activity [GO:0016874] EGEWDFYWCDVSWLRENFDHTYMDE;HTYMDEHVRISHFRN;KGHGLSKGKEREQRASIR;LYRDGFARFSNTRFTLS;VGGFDLMWND;YVAQRYIENP 6 19.3 0.97905 0.046227 0 0 0 0 0 0 0 0 7.10224 0 0 0 0 0 0 A0A8P0P497 A0A8P0P497_CANLF CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) CTPS2 Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' CTP biosynthetic process [GO:0044210]; glutamine metabolic process [GO:0006541] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883] ATGNLHGYLQQGCKLSS;EQVICIHDV;PEQVICIHDVSSTYRV 3 5.8 0.98925 -0.50844 0 8.90207 0 0 7.10518 0 0 0 0 0 0 0 0 0 0 A0A8P0P4A7 A0A8P0P4A7_CANLF Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) JADE1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] metal ion binding [GO:0046872] CHQHSDYPYLGLGRVP;DSPRAAAASPGTGQSAPGSRKEI;FTHLRQDLE;KERAKNKLK;KKDEEDNLAKR;QPDLCGRREGTVVPE;VARALRLP;VVCDVCQSPDGEDGNEMVFCD 8 14.6 1.0045 -1.046 8.33718 0 0 8.73457 8.49653 0 8.94752 11.2146 7.63241 0 0 7.34961 8.17103 0 0 A0A8P0P4C0 A0A8P0P4C0_CANLF Tripartite motif containing 4 TRIM4 Canis lupus familiaris (Dog) (Canis familiaris) GAGDISFYSAVDG 1 4 0.94011 0.059733 0 0 0 0 0 0 0 9.052 0 0 0 0 0 0 0 A0A8P0P4C9 A0A8P0P4C9_CANLF Vacuolar protein sorting-associated protein 18 homolog VPS18 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872] LDARQLIPAL;VPHPGAVL 2 1.8 0.98982 -0.26592 0 0 0 0 10.3302 0 0 0 0 0 0 0 0 0 0 A0A8P0P4D1 A0A8P0P4D1_CANLF Pleckstrin homology and RhoGEF domain containing G4B PLEKHG4B Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] AVRGCDVNLKE;ELGQEAERRPHEPSWTP;GGLLGGRVEGTSS;RRKSQDTYVLQAS;SDSSTSSSSSQSSSVLG;VGSLKALHKLV 6 5.5 0.98743 -0.35314 0 0 0 8.49362 0 0 0 2.20495 0 0 0 0 4.90776 0 9.55044 A0A8P0P4F7 A0A8P0P4F7_CANLF Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) PDGFA Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] membrane [GO:0016020] growth factor activity [GO:0008083] AEEAEIPREVI;CSQCSDSL 2 4.5 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 8.78463 0 0 A0A8P0P4G4 A0A8P0P4G4_CANLF Biotinidase (EC 3.5.1.12) BTD Canis lupus familiaris (Dog) (Canis familiaris) "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]" HSEMMYDNFTLVPV;LVRWNPCLEPHRF;NTNVVFSNNGTLVDRYRKHNLYF 3 9.4 0.99516 -0.15399 0 9.54776 0 0 4.56596 9.94658 0 0 0 0 0 0 0 0 0 A0A8P0P4I2 A0A8P0P4I2_CANLF ATP-dependent DNA helicase (EC 5.6.2.4) RECQL5 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA replication [GO:0006260]; regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; nucleus [GO:0005634] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] EGRDEAHKREWNLFYQKQMSL;EKTQAEERAP;GDQGSPEGQPIP;IPAWNQDTL;WNIAKSMAGYYQESG 5 7.5 0.99169 -0.51174 0 0 0 0 0 0 0 9.9633 0 0 10.6446 0 12.551 9.39887 0 A0A8P0P4I4 A0A8P0P4I4_CANLF Actinin alpha 3 ACTN3 Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779]; calcium ion binding [GO:0005509] APYKGSGAPPGALDY;DGLALCALIHRH;EQVEKGYEDWL;GEGPFVGGSGGGEYM;VFDNKHTVYSMEHIRV;VISEIVDGNLK 6 8 0.99157 -0.28759 0 13.8465 0 9.08401 9.24358 9.52362 9.75687 9.67848 10.6876 7.55228 0 7.57652 7.69153 6.62623 7.31533 A0A8P0P4K7 A0A8P0P4K7_CANLF Neuregulin 2 NRG2 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] extracellular region [GO:0005576]; membrane [GO:0016020] growth factor activity [GO:0008083] ASASDDDA;GKDTVRGRLHVNS;IDSLRDSPHSERYVS;LTTPARLSPVDFHYSLAT;PGPGPGAD;SSSGGGGS;SSSSGGGG;VGIVCVVAYC;VGTSKCNSPACVEARAR 9 12.2 1.0007 -2.7678 0 0 6.42264 0 0 0 0 13.6728 0 0 0 10.47 12.9294 0 12.4167 A0A8P0P4L0 A0A8P0P4L0_CANLF CCR4-NOT transcription complex subunit 3 CNOT3 Canis lupus familiaris (Dog) (Canis familiaris) nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of DNA-templated transcription [GO:0006355]; regulation of translation [GO:0006417]; regulatory ncRNA-mediated gene silencing [GO:0031047] CCR4-NOT core complex [GO:0030015]; nucleus [GO:0005634]; P-body [GO:0000932] GSKPVHSNQHPQSPA;LVPLPVNP 2 3.2 0.98486 -0.44735 0 0 0 0 0 0 0 0 0 7.59828 0 0 0 0 0 A0A8P0P4P0 A0A8P0P4P0_CANLF NEDD4 binding protein 2 like 2 N4BP2L2 Canis lupus familiaris (Dog) (Canis familiaris) AILCHQYGSRTL;DIQGGSTD;DRYEYEMSI;EDTKRESVHDF;KIMGENSFEILSYHIPGDQDPS;KLQKLLILLRGLP;LFGSPGVP;YHLNIQRF 8 7.6 0.99295 -0.17069 0 8.66181 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P4P1 A0A8P0P4P1_CANLF Hydroxysteroid 17-beta dehydrogenase 4 HSD17B4 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] peroxisome [GO:0005777] "oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]" EPKDMKFIYEGS;EWHITKGGNIAAKWTIDL;IDLKSGFGKVYQ;SEELQSTLVFEEIGRRLKDIG;SNIHCNTIAP;VGGGWIGK 6 10.9 1.0021 -1.8819 0 0 0 9.51964 4.9726 8.88402 0 0 0 5.63102 7.48824 0 0 0 0 A0A8P0P4S6 A0A8P0P4S6_CANLF N-lysine methyltransferase SETD6 (SET domain-containing protein 6) SETD6 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] protein-lysine N-methyltransferase activity [GO:0016279] FMEAHPDLFSPRVRS;GVPEAVEKD;TVAGYGMVARESVQ 3 9.1 0.98769 -0.40324 0 8.05485 0 0 0 0 9.16191 0 7.53426 0 0 0 0 0 9.13327 A0A8P0P4T0 A0A8P0P4T0_CANLF acid phosphatase (EC 3.1.3.2) ACP6 Canis lupus familiaris (Dog) (Canis familiaris) IIHTDEASSEVLYP;MFAGQLTNVGMQ;PQKQQAEWNL;YHTLCSQVQVME 4 11.2 1.0024 -1.4059 0 0 0 9.25475 0 0 0 0 10.1236 0 0 0 0 0 0 A0A8P0P4T4 A0A8P0P4T4_CANLF "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6" ST6GALNAC6 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] LSQWPRIYWRWLE;MEAYAVSP 2 4.3 1.0018 -1.4285 6.86319 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P4W7 A0A8P0P4W7_CANLF GPN-loop GTPase (EC 3.6.5.-) LOC475707 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GTP binding [GO:0005525]; GTPase activity [GO:0003924] FPTVVIYIMDTSR;LDEEDDEADSDTDDIDH;LERLRKDMGSVALDTGTAT;TLDEEDDEADSDTDD 4 17.9 0.99277 -0.049521 0 8.24565 0 0 0 0 0 0 0 0 10.3507 5.58958 0 0 4.55674 A0A8P0P4W9 A0A8P0P4W9_CANLF Mitochondrial fission regulator MTFR1 Canis lupus familiaris (Dog) (Canis familiaris) aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] mitochondrion [GO:0005739] GVSMQSVLWSGKP;SEKRIPKLA 2 6.6 1.0033 -1.0572 0 0 0 0 0 0 0 0 0 0 0 0 13.6668 0 3.06597 A0A8P0P4X0 A0A8P0P4X0_CANLF Olfactory receptor OR5H9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AGSIQMFTILIVLVS;AHLLSVSLYYSAL;IVHHFYCDIIPLLKI 3 13.7 0.99347 -0.046698 0 0 8.7846 0 0 0 7.81526 0 0 0 0 10.1273 0 0 0 A0A8P0P4X3 A0A8P0P4X3_CANLF Pleckstrin and Sec7 domain containing 3 PSD3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] EILEKEASESL;EPDSYFSFDMP;GVATCQVLPKS;KEIDEYRLKDHYLEFEKTRYEIYV;NVEAARRLARRLYQLDRFKRS;TTNPFLDIPHDPNAAVYKSGFLAR;VLSISAVGEIVMG;YCPPIQICRSSP 8 11.2 0.93192 0.096906 10.501 0 9.7225 7.91193 0 0 11.6578 0 8.52654 5.49403 0 0 7.62972 0 0 A0A8P0P4Y1 A0A8P0P4Y1_CANLF Ribosomal RNA-processing protein 43 EXOSC8 Canis lupus familiaris (Dog) (Canis familiaris) RNA catabolic process [GO:0006401]; RNA processing [GO:0006396] cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178] LCISPGKLSWVLYCDI;SQFIADVIENSQIIQKED;VLYCDIICLDYD 3 14.7 0.99437 -0.1241 0 0 0 0 0 9.15641 0 0 0 9.58633 0 0 0 0 0 A0A8P0P4Y2 A0A8P0P4Y2_CANLF Zinc finger protein 334 ZNF334 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] LSAHPKTLKERKSCESS;NCGKVFHKKTAFVTHKRPHKGE;SLHAMHEKIHAVNKPHES 3 9.1 0.98669 -0.45712 0 0 0 0 0 0 6.35526 0 0 0 0 0 0 0 11.7178 A0A8P0P4Z1 A0A8P0P4Z1_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1J" PPM1J Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] AGPRPRAGRGGSM;CFPEVRVYDLTQY;DEGPARRVGPAG;DLPSARSA;EDQACCEV;LVLGTDGLWDVTSDCEVAATVDRVL;TPGAPGSSDSSHLV 7 15.4 1.002 -1.8245 10.0539 8.45385 0 0 8.50454 0 11.2585 0 0 7.36063 0 0 0 0 0 A0A8P0P4Z9 A0A8P0P4Z9_CANLF Zinc finger protein 619 ZNF619 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872] ECGQAFSQNSHLLQH;LAQDYKSSSI 2 4.7 0.99182 -0.20876 0 0 0 0 0 0 9.78598 0 0 0 0 0 7.36098 0 0 A0A8P0P500 A0A8P0P500_CANLF Glucose-6-phosphate isomerase (EC 5.3.1.9) UBA2 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] extracellular space [GO:0005615] carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347] YSKNLVTDTVMQ 1 2.2 0.99033 -0.20008 0 0 0 0 0 0 0 0 0 0 0 0 11.1347 11.1752 0 A0A8P0P502 A0A8P0P502_CANLF Pleckstrin homology like domain family B member 2 PHLDB2 Canis lupus familiaris (Dog) (Canis familiaris) APPLGACA;HQKASLHDADLPVFGSIGQSSASL;NNLIMMLQREKENLCNLEKKYS;SAGYNHQQMSEG;SIPASPRVARK;SLDSSDSMETS;TLSIPASPRVARKMLL;VLCLRKSE 8 7.7 0.98548 -0.44359 7.2116 0 0 0 0 0 7.77314 0 0 10.4177 6.98903 5.79577 12.583 9.39161 0 A0A8P0P531 A0A8P0P531_CANLF Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) PMPCA Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] MMNLESRPVI 1 2.5 0.98362 -0.25261 0 0 0 0 0 0 0 10.7357 0 0 0 0 0 0 0 A0A8P0P534 A0A8P0P534_CANLF EBF transcription factor 2 EBF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ENDKEQGN 1 4 0.98898 -0.26498 0 0 0 10.6538 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P543 A0A8P0P543_CANLF Seipin BSCL2 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet formation [GO:0140042]; lipid metabolic process [GO:0006629] endoplasmic reticulum membrane [GO:0005789] EDGESPEDPPGAEG 1 3.1 0.9895 -0.21776 0 0 9.93484 0 0 0 0 0 0 10.049 0 0 0 0 10.1034 A0A8P0P558 A0A8P0P558_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP4A Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]; P-type potassium:proton transporter activity [GO:0008900] AAKNAADMILLDDNFASI;GKGGGKKK;PYWENHHLQDL;WREAFQTAYLSL 4 4.8 0.98979 -0.26592 0 0 0 0 0 0 0 8.09207 0 0 0 0 0 0 0 A0A8P0P577 A0A8P0P577_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AEAAEEAEEAASGC;EAGEAEAAGEAEAAEE 2 8.8 0.9898 -0.22278 0 0 0 0 5.11819 0 0 0 0 0 0 0 0 0 0 A0A8P0P5A5 A0A8P0P5A5_CANLF Brain enriched guanylate kinase associated BEGAIN Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFPAGFRHEAFPGYAASL;NSTDSAAEDEEEAEAE;PSAPPPPPAPRPGSQAS 3 7 0.97663 0.046227 0 0 0 0 0 0 0 0 0 0 0 8.20408 0 0 0 A0A8P0P5D4 A0A8P0P5D4_CANLF Cytoplasmic FMR1-interacting protein CYFIP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin filament polymerization [GO:0030833] cytoplasm [GO:0005737] small GTPase binding [GO:0031267] ALQDFSQVTLREPLR;LLDKRLRSE;VGPSSTQLY 3 2.8 0.99203 -0.2066 0 0 0 0 0 0 0 0 0 12.7787 0 0 0 10.7169 0 A0A8P0P5D8 A0A8P0P5D8_CANLF Rap-GAP domain-containing protein RALGAPA1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] nucleus [GO:0005634] GTPase activator activity [GO:0005096] ALLKYIVIQV;DHMEQKDL;EHTRDYRRGIIPTEF;EVHIVWSEHTR;IDQIVNTIIKHCSP;IKARVIVIRWLV;LVSCIQIRSEESIP;PDDLEISEFPSE;PEPLHSPDSERSS;PLNSDIGSSNVNVPD;RGIIPTEFGDVLII;YYLPYIFPNICKENSLYH 12 6.9 0.935 0.067384 0 0 0 0 0 0 0 0 0 0 7.83327 0 0 0 0 A0A8P0P5E3 A0A8P0P5E3_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP10D Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] CVLTTCVALL;EAYLPLTFWITLLDAFYQS;ESPDEAALVYAARAY;GSQRILDMTEFLRWA;IKDGLEDYRKYKIDKQ;LVCFFMPYYTYQGSDI;SPATQGSG;YARRGLRTLCIAKKVMSDTEYEEWL 8 8.4 0.9865 -0.33221 5.93376 0 0 7.2502 0 8.57509 0 0 0 0 7.43421 0 0 10.1869 0 A0A8P0P5F2 A0A8P0P5F2_CANLF Protein tyrosine phosphatase non-receptor type 20 PTPN20 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein tyrosine phosphatase activity [GO:0004725] DSFKMLEKKVAEY;SAGVGRTGVFLCVD;SAPRKATAESGEDEGD 3 10.7 0.9923 -0.033889 0 0 8.81474 0 9.06426 0 0 8.805 0 0 0 0 8.86722 7.70466 0 A0A8P0P5G6 A0A8P0P5G6_CANLF Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap1 2'O-ribose methyltransferase 1) CMTR1 RNF8 Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259] nucleus [GO:0005634] mRNA (nucleoside-2'-O-)-methyltransferase activity [GO:0004483]; nucleic acid binding [GO:0003676] HEFTDYMIRSNES;PSSVNHGA;TDRKGVHF 3 3.8 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 0 8.12629 0 0 0 0 A0A8P0P5H1 A0A8P0P5H1_CANLF Receptor protein-tyrosine kinase (EC 2.7.10.1) ERBB4 Canis lupus familiaris (Dog) (Canis familiaris) ERBB signaling pathway [GO:0038127]; regulation of cell communication [GO:0010646]; regulation of cell population proliferation [GO:0042127]; regulation of signaling [GO:0023051] membrane [GO:0016020] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] IDVYMVMV;IVGLTFAVYVRRKSIKKKRALRRFL;NLEITSIEH;PVAPHVQE;SICVECDPQC;TDCFACMNFNDS 6 5.9 1.0031 -1.497 0 0 0 0 0 0 4.27687 0 0 0 0 9.95555 0 7.67582 0 A0A8P0P5I4 A0A8P0P5I4_CANLF TGF-beta family profile domain-containing protein LOC490387 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083]; transforming growth factor beta receptor binding [GO:0005160] LDEGDVEALVTP;VTIEWLQVRDDGP 2 8.7 0.76243 0.23541 0 0 0 0 0 0 0 0 14.8714 0 0 0 0 0 0 A0A8P0P5K2 A0A8P0P5K2_CANLF Importin subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737] nuclear import signal receptor activity [GO:0061608] FFIVMFLNNYLTR;QAAEKLGETEKLSIM;VEQIVYLVHCGI;VHCGIIEPLKN 4 9.8 0.98331 -0.25179 0 10.8803 0 0 0 13.1926 0 0 0 13.8601 0 0 0 7.79331 0 A0A8P0P5K3 A0A8P0P5K3_CANLF Tripartite motif containing 65 TRIM65 TRIM47 Canis lupus familiaris (Dog) (Canis familiaris) GTEADAESQDPDSTNNVESEAP;LGEGALDRGTYYWEVEI;RVRDVLEHLDDRTFLQE 3 9 0.98541 -0.4364 0 10.6814 6.74766 0 0 0 0 0 0 0 0 8.49145 0 0 0 A0A8P0P5K4 A0A8P0P5K4_CANLF RAP1 GTPase activating protein 2 RAP1GAP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] EAMEECDSGV;KFGVIYQKARQT;SQMIVSYDEHDVNNTFKFG;VESVYTVFR 4 6.9 0.99978 -0.61146 6.96901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P5L6 A0A8P0P5L6_CANLF Pyridoxal dependent decarboxylase domain containing 1 PDXDC1 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] carbon-carbon lyase activity [GO:0016830]; pyridoxal phosphate binding [GO:0030170] APPPASPRPADFPP;HACQLSQRLQES;SLEKIADPTLAEMG;SLNGCFFSILNIL 4 5.6 0.98773 -0.37265 0 0 0 0 0 10.3207 0 0 0 0 8.6001 0 0 9.58278 0 A0A8P0P5L9 A0A8P0P5L9_CANLF Elongation factor 1-gamma (eEF-1B gamma) Canis lupus familiaris (Dog) (Canis familiaris) translation elongation factor activity [GO:0003746] AFEGDDGFCVFESNAIAYYV;DWQVDYESYMWWKL;VIFFGTNNSS 3 11.4 1.003 -0.87968 0 0 0 0 7.91229 8.61442 0 0 0 0 9.17478 0 0 0 0 A0A8P0P5M6 A0A8P0P5M6_CANLF Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (Serine-palmitoyl-CoA transferase 1) SPTLC1 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] membrane [GO:0016020] acyltransferase activity [GO:0016746]; pyridoxal phosphate binding [GO:0030170] AAALASLKKY;FMKTEEAIIYSY;GVTEHFGISIDDIDLISAN;IDDIDLISANMENSLA;KDSTGSREKDVKLL;LEGILILWIIRLLFSK 6 17.3 0.98715 -0.23444 0 6.32859 8.84442 0 5.83658 11.5874 0 0 0 0 4.28214 0 0 0 11.0524 A0A8P0P5Q1 A0A8P0P5Q1_CANLF DUF4515 domain-containing protein CCDC166 Canis lupus familiaris (Dog) (Canis familiaris) AAFEREARQ;FLDAEALRL;VRLDEQHRADL 3 6.7 1.0033 -1.0348 0 0 0 0 0 8.08385 10.2684 0 0 0 7.54218 0 13.2124 8.53815 0 A0A8P0P5R8 A0A8P0P5R8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEDEAEYYCSSWDDSL;EDEAEYYCSSWD 2 11.7 0.99129 -0.22183 0 0 0 0 0 0 0 0 9.92705 4.67948 0 0 0 0 0 A0A8P0P5S7 A0A8P0P5S7_CANLF SPOC domain containing 1 SPOCD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] PQGARDTQNCRLLYSYLNNKQ;TEQDEDTTEQ;VIHLLGAISHGQAG 3 5.3 1.0027 -0.84521 6.45699 0 0 0 7.63278 0 0 0 0 0 0 0 5.88772 0 0 A0A8P0P5U7 A0A8P0P5U7_CANLF Sprouty related EVH1 domain containing 1 SPRED1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] membrane [GO:0016020] GEACGCCGG;LKFKKSKRRK;SCDTSDDKFCLRWL;YHCMSDSEGDFSD 4 11.2 1.0037 -1.6742 7.9279 0 0 0 0 5.8516 0 4.65821 0 0 0 0 0 0 0 A0A8P0P5V5 A0A8P0P5V5_CANLF Coenzyme Q8B COQ8B Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399]; positive regulation of neurogenesis [GO:0050769] CRASSPCCCSI;DEDAVRKGTCSFPV;DPFEAQWAALEGK;TAAPGPAQ 4 6.5 0.99685 -0.59065 0 0 10.4775 0 0 7.23477 0 0 0 0 0 9.89028 9.71725 9.97269 0 A0A8P0P602 A0A8P0P602_CANLF Annexin ANXA2 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phospholipase inhibitor activity [GO:0004859] PVVSLGTGVTVCAV;TNQELQEINRVYKEMYKTDLEKD 2 10.3 0.9957 -0.56998 0 0 0 0 0 0 0 6.85062 0 0 10.324 0 0 0 0 A0A8P0P603 A0A8P0P603_CANLF Cell division protein kinase 5 CDK5 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic density [GO:0014069] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ILLHIQHDLQPIAHAA;PAMTKLPDYK 2 7 0.9863 -0.45119 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.561 A0A8P0P616 A0A8P0P616_CANLF Metallothionein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CCSCCPEGC;KSCCSCCPEGC;SCCSCCPEGCAKYAQAA 3 22.5 1.0028 -0.7225 4.13496 0 6.38334 3.08338 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P639 A0A8P0P639_CANLF Epiplakin 1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] EETEEQYRGMKV;ELVREYKEHVNQ;GGGGGGGA;IDPTGHYHLPLPVAT;IITQETLTALAQ;IPMGFAVQMLEAQAA;LDNLAQGTKTPQEV;LVAEQAVTGYH;LVSDQRHMRKRFVDPNNQERVTYQ;PGGGGGGG;VHLPEAVACRL 11 3 1.003 -1.588 7.76911 10.5822 0 0 0 8.25456 12.0054 11.0987 10.0539 9.44497 11.2357 0 11.9646 0 0 A0A8P0P646 A0A8P0P646_CANLF Phosphatidylinositol-glycan biosynthesis class X protein PIGX Canis lupus familiaris (Dog) (Canis familiaris) GPI anchor biosynthetic process [GO:0006506] endoplasmic reticulum membrane [GO:0005789] DVTVKRIP;HPSAAHGA;NIEAPNYLSKE;RAAPSSVPVARYAAARSRS;VLIYARQDSQCIDCFQAFLPVHYR;YLSKESEVLIYARQDSQCI 6 15.2 1.0032 -2.4039 0 0 0 0 8.01167 0 0 12.3616 14.7102 0 0 0 0 0 0 A0A8P0P663 A0A8P0P663_CANLF Acid sensing ion channel subunit family member 5 ASIC5 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] membrane [GO:0016020] sodium channel activity [GO:0005272] FAHVFTEY;GFYLNNRTLLECNFFGKPCGPQ;SITEFVKKNGFYL 3 8.3 1.0026 -1.3554 0 0 0 0 0 0 0 0 0 9.06221 0 0 7.25257 0 0 A0A8P0P699 A0A8P0P699_CANLF Transmembrane protein 161A TMEM161A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ADSGADRWGPGQPA;QPAHAPLPPRHPHL;YKHPTEEELRSLE 3 7.4 0.98916 -0.50728 0 0 8.96099 0 0 0 0 10.2142 0 0 0 0 0 0 0 A0A8P0P6B2 A0A8P0P6B2_CANLF Centrosomal protein 128 CEP128 Canis lupus familiaris (Dog) (Canis familiaris) AASSSCHSCDSGEST;DLQISELTH;DWRFRRGVEQEK;IQNHFETCEAKHKRADLQ;LFEQIERQEQ;PRGPSGSSGVLFSRC;QLRSQRLLRHSG 7 7.7 1.0019 -0.6704 0 7.8756 0 8.31447 0 4.78701 10.0214 0 0 0 0 0 9.40414 0 0 A0A8P0P6B4 A0A8P0P6B4_CANLF Protein O-glucosyltransferase 2 POGLUT2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum [GO:0005783] ARYFYIQAVDTS;AVVLPARYFYIQ;FFVNLGDWPLEKKKS;IVMPTYDLTDSVLETMGR;PEKSEIWG;SPEKSEIWG;YYFKLFQEYASLQV 7 14.6 0.98904 -0.5227 0 0 10.257 0 0 0 9.55221 9.04371 0 9.73828 10.0638 0 10.0672 0 9.7525 A0A8P0P6D1 A0A8P0P6D1_CANLF Glucosaminyl (N-acetyl) transferase 2 (I blood group) GCNT2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757] DMEDKHGGCHG;FETFARLFRAI;FPNAFLASRMEP;FRAIYMPQ;PPHNLTIYFGSAYVALSREFTDFVL;TTLSDSTCYEYMAQSHYITQ;VEQLLSCFPNAFLA 7 15 1.0036 -0.83475 0 0 0 0 0 10.2248 9.64301 0 11.9036 0 0 0 8.80307 10.3875 10.4012 A0A8P0P6E4 A0A8P0P6E4_CANLF RELT TNF receptor RELT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APKAGAKA;EVLLSPEAAAATTPT;SGGDLPDSPQPGL 3 8.4 1.002 -1.2717 0 0 12.9294 0 0 0 7.84524 0 0 0 0 5.46686 0 0 0 A0A8P0P6F3 A0A8P0P6F3_CANLF Apolipoprotein C-IV (Apolipoprotein C4) APOC4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EEGAGDLDPW 1 8.3 0.99854 -0.61146 0 0 0 0 0 0 0 0 0 0 0 12.0643 0 0 11.5843 A0A8P0P6F7 A0A8P0P6F7_CANLF Cyclin-dependent kinase-like 2 (EC 2.7.11.22) CDKL2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DPKIKDSKVFKIK;GVAIPPLAH;SLATIDLHTPSITL;VPSTSLRDCSNGSMDHTRNPGVAIP 4 9.8 1.0024 -1.0208 0 0 0 0 0 0 0 13.3032 5.3844 0 0 0 0 0 6.99209 A0A8P0P6J2 A0A8P0P6J2_CANLF Xanthine dehydrogenase XDH Canis lupus familiaris (Dog) (Canis familiaris) "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; xanthine dehydrogenase activity [GO:0004854]" EMGQGLHTKMVQEACK;GEAVYCDDIPRYEN;HGLEGISFGAACPL;IAEYWMSEVAMTCGLPAE;IPRYENELSL;IVHFSANACLAPICSLHHVA;LGCGEGGCGACTVMLS;NPAIDIGQVEGAFVQ;RALFHMDNCYKIPN;TGIFNDETIFAEDE 10 11.3 0.061224 1.019 11.5429 10.2656 0 0 0 0 10.1285 6.82807 6.49063 0 0 11.8519 0 6.3457 0 A0A8P0P6K8 A0A8P0P6K8_CANLF ZZ-type domain-containing protein DTNB Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ILFSCTSSSPQS;PEKAQQNPTL 2 2.8 0.94706 0.05044 0 0 0 0 0 0 0 9.27277 0 0 0 0 0 0 0 A0A8P0P6N1 A0A8P0P6N1_CANLF Coiled-coil serine rich protein 1 CCSER1 Canis lupus familiaris (Dog) (Canis familiaris) EVLLQITELPVM;LMGTVPCAI;LVSDKNTWP;LVSRLPIFRRSISRRHD 4 6.6 1.0022 -1.2018 0 0 0 0 0 0 0 10.5107 0 0 0 0 8.70515 0 0 A0A8P0P6N3 A0A8P0P6N3_CANLF Tumor protein p53 binding protein 2 TP53BP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981] nucleus [GO:0005634] p53 binding [GO:0002039] DCMTVIRREDEDET;EQEKLKKLK;LEEYPPYP;LVESGAAVFATTYS;PKTGQQQRLMGSP;PYPPPPYPSGEP;VFATTYSDMQTA 7 6.6 1.0026 -1.7469 0 10.0661 9.86364 0 8.70432 0 0 0 0 2.95567 9.95466 8.79009 8.79217 0 0 A0A8P0P6T5 A0A8P0P6T5_CANLF Castor zinc finger 1 CASZ1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AACQFSLKVTHYHCTRE;DADDDEDDDEDDDDEDDDD;DDEDDDDD;DDEDDDDEDDDDEDDDDD;EDADDDEDDDEDDD;EDDDDEDDDDEDDDDDEDLRTDSEE;HYHCLDPECNYQ;SQGPPSLMD;VIEKWVNGEYSEE 9 4.9 0.98929 -0.21881 0 0 0 0 0 9.59167 0 0 0 0 0 0 0 0 6.37905 A0A8P0P6U8 A0A8P0P6U8_CANLF Trefoil factor 2 TFF2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ECFNTGCCFDS;PGCWGAAG 2 10.7 1.0023 -1.4062 0 0 0 0 0 0 0 0 12.03 0 0 0 0 0 0 A0A8P0P6W0 A0A8P0P6W0_CANLF "ArfGAP with SH3 domain, ankyrin repeat and PH domain 2" ASAP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872] DLKGVKGD;HIVDFLVQNSGNLDKQTGKG;KYARKRHADN;LQVEQKEDSQIRQSTA;NTVAAIEE;SEFVAETHEDY;VDEKLQPSPSR;YHFQAEDEQECQIWMS 8 10.4 1.0019 -1.3017 7.78483 0 0 0 0 11.3333 0 0 9.08271 9.01044 9.39483 8.81893 8.20545 0 0 A0A8P0P6Y5 A0A8P0P6Y5_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) FLT3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] EDYEIDQYEEFCFSV;EIEYENQKRLEEEEDLNVL;FKAYPQIRCTWTF;NDTGYYTCSSSEHPS 4 6.9 0.98666 -0.41917 0 0 0 0 6.01047 0 0 10.3285 0 0 0 0 9.49438 0 0 A0A8P0P6Y9 A0A8P0P6Y9_CANLF Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (Parathyroid hormone 1 receptor) PTH1R Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] parathyroid hormone receptor activity [GO:0004991] ILVEGLYLHSLIF;LSWWPLLPDLCTACPASPG 2 4.9 0.94931 0.049747 0 0 0 0 0 0 0 0 0 0 0 0 7.10518 0 0 A0A8P0P6Z6 A0A8P0P6Z6_CANLF Replication timing regulatory factor 1 RIF1 Canis lupus familiaris (Dog) (Canis familiaris) "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" AAGELDEGSDESGP;CDMDSEEATS;DPEEKVIKQECI;DSELLEQISPLL;EDGDSTKISTIPVEAETKTS;ETSQSRTS;EVWWYLLMRLGP;IDNFALNPEI;LCSKMMSSLEDSGF;NFSAIYGALTLPIHH;PRMNLSSNLGGMATIPSI;SEVERDLK;SFAKQNKLVLSLEP;SLFKLIVRVI;SPQKLRELDPLF;STKGFLSP;TELKENPT;VKLKLESSSSKTKSEMPL 18 9 0.99653 -4.8855 10.6059 11.4925 0 6.86765 0 0 14.6463 10.8834 11.9035 8.24012 0 0 0 0 10.406 A0A8P0P702 A0A8P0P702_CANLF Non-SMC condensin II complex subunit G2 NCAPG2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EVQGEDIMETEHE;ILARLESDSRP;LDELKVCV;NELLDELSRKQKEE;PIRDPNFNAI;VHLQHQTY;VLSYFHHQKKV 7 6.9 1.0029 -0.83948 0 0 0 0 2.5085 3.8847 14.1564 10.6628 7.88289 0 0 0 0 0 0 A0A8P0P706 A0A8P0P706_CANLF Cilia- and flagella-associated protein 91 CFAP91 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DVAYEMESRRTQLQ 1 2 0.94415 0.077062 8.70898 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P714 A0A8P0P714_CANLF "Spliceosome associated factor 3, U4/U6 recycling protein" SART3 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] AEQRKRARAEKKALKKKKKTRGA;AMERHGVDHRVISDSSKE;DIRLVTNRAGK;MGLFGKSAPVDVDP;VISDSSKELEELRS 5 7.8 0.97906 0.046253 0 0 0 0 0 0 7.78953 0 0 0 0 0 0 0 0 A0A8P0P718 A0A8P0P718_CANLF Doublesex and mab-3 related transcription factor 1 DMRT1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; regulation of DNA-templated transcription [GO:0006355]; sex differentiation [GO:0007548] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] AADSSSGDVGSPLGGSPV;AGGFGKAA;SLVSPLLDYTFP 3 10.4 0.98667 -0.23173 0 0 0 0 0 9.3581 0 0 0 0 0 0 0 0 0 A0A8P0P729 A0A8P0P729_CANLF "FYVE, RhoGEF and PH domain containing 4" FGD4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] ISTAASHSNSAIRK;LSSAEPRME;MIIKRVKPNISLSKQVR;RACGHVVCWKC;VNGEGEEEATTRPA;VNKIFSNISSINAFH;VSQQPPQKQEN 7 10.6 0.98618 -0.41322 0 0 11.554 0 0 0 0 0 4.95503 6.89954 0 0 12.2608 0 6.44367 A0A8P0P733 A0A8P0P733_CANLF Protein-serine/threonine kinase (EC 2.7.11.-) BCKDK Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LPFIIGCNPTILHVHELY 1 5.4 0.97996 0.048313 0 0 0 0 0 0 0 7.55136 0 0 0 0 0 0 0 A0A8P0P738 A0A8P0P738_CANLF long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSBG1 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] cytoplasm [GO:0005737] ligase activity [GO:0016874] DIQPAEVQ;HIQKWAILQKDF;SEETLWTTRAD;VNEDSEGVGEICLWGRTIFMGYLNM 4 8.2 0.99706 -0.58714 0 0 9.39204 0 10.6557 0 0 9.78396 0 0 0 0 0 0 9.56877 A0A8P0P745 A0A8P0P745_CANLF Bromodomain-containing protein 9 BRD9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GVQCALSLQEFVKD;KKKKKKKK;SEKEKHLDDEERRKR;SLQEFVKDAGSYSKKMVDDLLDQI;VGEQPEVTHDPYE 5 11.1 0.98969 -0.22339 12.4105 0 0 0 11.1781 6.80064 0 0 8.49909 0 0 0 8.58365 0 0 A0A8P0P746 A0A8P0P746_CANLF IQ motif containing F1 IQCF3 Canis lupus familiaris (Dog) (Canis familiaris) PLTKKKKLPDRERKAIKIQ 1 8.2 0.95261 0.04941 0 0 0 0 6.48525 0 0 0 0 0 0 0 0 0 0 A0A8P0P750 A0A8P0P750_CANLF Spectrin repeat containing nuclear envelope protein 2 SYNE2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nuclear envelope [GO:0005635] AEHLGEMNRQWHRVHGTL;ALPLQLLLLLLLL;ALPLQLLLLLLLLLACLL;CNLEKVQIMLQEKYSEDQHSTTLK;DKLYHQEKEENPDL;EKYLQSKEDLRLMLTELK;ELCAWLVQMENKVLQ;ESCKDLGPGDSG;HLDSLLQALITLKKKK;HLHRQWEDL;HNILHSIFTDLEDLSIIFETD;HQLSQDLLLWLAS;ILQQKHSMMLLENQ;IRAALPLQLLLLLLLLL;IRAALPLQLLLLLLLLLACLL;KATVKMEEYHDLLKSTEAWIEN;KEHEACFSEEASLYQ;LHDSDACANETECDSIQ;LLLLLLLL;LLLLLLLLL;LNTSIDLRTDVLND;LQQDVQKTK;NEKDYCFLWRKEINY;QENKELMENEIQER;QEQADVCKDLCVFERLFLGDQLKN;RNLQFHLNKMRIFEEPPFE;RVIRAALPLQLLLLLLLL;SFELSASDTQVVPEDTLTVENKKGE;SFQNMELQDHPE;SLLKELKSQGSYLLECTKNP;TQAKELNDH;VEHFSESDADDKMR;VGGSSSHEDDEEGPYYSALSD;VSKIKAILL;WTQVNQDIAEQLQKAQSLLQ 35 7.1 0.95335 0.053874 0 0 0 0 0 0 0 5.19614 0 0 0 0 0 0 0 A0A8P0P770 A0A8P0P770_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 3" AGAP3 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] ESVHPNIYAIYDLIE;FVNSQEWTL;GGGGGGGA;GGGGGGGG;IPAVHINQSRKG;LALDRSNTQLGGGTGA;PGGGGGGG;VHPNIYAIY 8 7.5 1.0025 -1.1724 0 0 0 6.41919 0 0 0 12.0793 0 0 0 8.07339 11.2404 0 7.91546 A0A8P0P773 A0A8P0P773_CANLF Kinesin family member 1A KIF1A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; microtubule [GO:0005874]; synapse [GO:0045202] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] DTSVAYVRGEEN;GLGDITDTNTVPGGPK;TEPLKNTGRG;TNITTEKVSKIS;VGEEEEEEEEEEEEEEDL;VPGGPKLTNALV 6 4.1 0.97683 0.048313 0 0 0 0 0 0 0 0 7.53068 0 0 0 0 0 0 A0A8P0P788 A0A8P0P788_CANLF "Membrane associated guanylate kinase, WW and PDZ domain containing 1" MAGI1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGIVHAENEEEDDVPE;GGGGQRVK;GPQGELGVTVLGGAE;GVHTEELDSELELPAGWEKIEDP;QLEQQQQPQQQQQQQQQQQQPP;TITTTHTPSQQGTQET;VQPYDVEIRRGENEG 7 9.2 1.0026 -1.4009 11.182 0 6.48564 0 0 0 0 9.81845 6.38237 0 0 9.89857 0 6.77768 6.98516 A0A8P0P791 A0A8P0P791_CANLF adenylate cyclase (EC 4.6.1.1) ADCY9 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] membrane [GO:0016020] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphorus-oxygen lyase activity [GO:0016849] DELLSRPGYSS;EEACMERCFPQT;KNHDSGGV;QEVILVFFLLLLLVWFLNR;SEGNPCNNS;TDEIANLVPS;TKAPGAPN;VFFLLLLLVWFLNREFEVSYRLHYH;VGQSIMHGKDLEVEKALKER;VGVHTGTVLCGI 10 9.7 0.99832 -3.2989 9.35282 0 0 0 5.49605 0 0 0 7.67285 0 8.70162 0 5.62559 0 10.2827 A0A8P0P798 A0A8P0P798_CANLF cAMP responsive element binding protein 5 CREB5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] FWPYMDNIHNL 1 2.7 0.98573 -0.23256 0 0 0 0 0 0 0 0 0 0 0 8.48949 0 0 0 A0A8P0P7C6 A0A8P0P7C6_CANLF "Serine peptidase inhibitor, Kunitz type 2" SPINT2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] serine-type endopeptidase inhibitor activity [GO:0004867] NKNNYMTKEECLKKCAGVTE 1 8.4 0.94866 0.05015 0 0 6.04337 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P7C7 A0A8P0P7C7_CANLF ADP ribosylation factor interacting protein 2 ARFIP2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] protein domain specific binding [GO:0019904] ADLSQKSPELQ;FLEENKSTPRYRH 2 6.5 0.99115 -0.2213 0 0 0 0 0 0 0 0 0 0 0 0 6.95768 0 0 A0A8P0P7E0 A0A8P0P7E0_CANLF Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) NR1D1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] dendritic spine [GO:0043197]; nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] FDFSEKLNSL;PLVGFSQFPQQLTPP;QDPARSFG;SRTTYSLQE;VSAGRSSSR 5 8.6 0.98654 -0.45064 12.881 0 12.9705 0 0 0 0 0 12.9904 13.923 0 0 0 13.8121 12.104 A0A8P0P7E3 A0A8P0P7E3_CANLF Cytochrome c oxidase subunit 6B2 LOC119870901 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277] GGARVEGPVQLSRR 1 11.3 0.94179 0.061073 0 0 0 0 8.61408 0 0 0 0 0 0 0 0 0 0 A0A8P0P7F5 A0A8P0P7F5_CANLF Cilia and flagella associated protein 161 CFAP161 Canis lupus familiaris (Dog) (Canis familiaris) EDIYLEEELMKDFL;WLQEVYLTDEVSYLNCWQ 2 10.2 0.99423 -0.15463 9.80352 0 0 0 0 0 10.8708 0 0 0 0 0 0 0 0 A0A8P0P7G8 A0A8P0P7G8_CANLF Ring finger protein 123 RNF123 Canis lupus familiaris (Dog) (Canis familiaris) SPEHAPTAATSRQPLS 1 22.5 0.96199 0.049233 0 0 0 0 0 0 0 0 8.58402 0 0 0 0 0 0 A0A8P0P7H7 A0A8P0P7H7_CANLF NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) UBA3 Canis lupus familiaris (Dog) (Canis familiaris) protein neddylation [GO:0045116] ATP binding [GO:0005524]; NEDD8 activating enzyme activity [GO:0019781] NLNRQFLFRPKDVGRPKAE;VKKFLERSGPFTHPDFEPSTES 2 9.3 0.99229 -0.20642 0 0 10.1631 0 0 0 0 0 0 6.39698 0 0 0 0 0 A0A8P0P7K1 A0A8P0P7K1_CANLF Plasmolipin PLLP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LGALMLLQL;LGFVRSSLGALML;SLKGTRPYNQRAAASFFSCL 3 29 1.0031 -1.0306 0 9.07497 0 0 0 0 0 12.8624 0 0 0 0 0 0 0 A0A8P0P7M7 A0A8P0P7M7_CANLF Chondrolectin CHODL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VIPTIPLLLLI;YLYQWNDDRCNMKHNYICKYEPEI 2 15.1 0.94555 0.076793 0 0 0 0 0 4.09913 0 5.18233 0 0 0 0 0 0 0 A0A8P0P7N3 A0A8P0P7N3_CANLF Calcyphosine 2 CAPS2 Canis lupus familiaris (Dog) (Canis familiaris) EGYKQYSQRNAEKTKS;GEMNEYRK;YQQYETEMKEGYKQYSQRNAE 3 6.5 1.0024 -0.71551 0 0 0 0 0 0 0 0 0 0 9.51031 0 0 0 0 A0A8P0P7Q9 A0A8P0P7Q9_CANLF "BCAR1 scaffold protein, Cas family member" BCAR1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] GVGSGPVG;LLFYLEQCE;PRERLLPPEAADGGV;QSRPLPSPPKFTSQD;QSRPLPSPPKFTSQDSPDG;QYTPMLPAT;SPPKFTSQDSPDGQYENSEG 7 6.6 0.98918 -0.26225 0 0 0 0 0 0 0 0 0 0 0 9.39212 0 0 9.40414 A0A8P0P7S3 A0A8P0P7S3_CANLF Ankyrin repeat and fibronectin type III domain containing 1 ANKFN1 Canis lupus familiaris (Dog) (Canis familiaris) DEEGCSEVFLPTDSDYDSSDA;EGCSEVFLPTDSDYDSSDALS;EQQDMDAVQILLYQYTPEELD;HSLSLSGFPSKNHAKMAPGS;KRKPPKHQ;SAYNMKGWGPAQT;VHRLGRGRGRLKLPHRLPF;WVQKLSGSESMESVDHTPDCPM 8 9.7 1.0022 -1.2969 0 0 9.36964 0 0 0 0 0 10.05 0 11.8329 11.3461 10.7409 8.66473 0 A0A8P0P7T0 A0A8P0P7T0_CANLF arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) RARS2 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA aminoacylation [GO:0006420] cytoplasm [GO:0005737] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524] EALGHQVTRINYL;RFDEVLYRSSQDLQ;SILQHLLRFDEV;VLENPQET 4 8 1.0021 -1.2928 0 0 6.45325 0 0 6.78986 0 0 7.66021 0 0 0 7.17213 0 0 A0A8P0P7U3 A0A8P0P7U3_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) CTDSP2 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420] AQPRLRARRPRAQPARARGVVRW;LKRPYVDEFL;QSWFDDMADTEL;VEIEGTTHQVYVLKRPY 4 20.4 0.98718 -0.46327 0 0 0 0 0 0 0 0 0 0 9.49235 5.04902 8.68618 0 0 A0A8P0P7U5 A0A8P0P7U5_CANLF Sorting nexin 1 SNX1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] early endosome membrane [GO:0031901]; lamellipodium [GO:0030027] phosphatidylinositol binding [GO:0035091] ASSRRRMLSRRPA;DVREFLEKEE;ESDIWFEEKL;KDEILEWESRVTQYERDFERISTVV;VEEKIEQLHQE 5 12.3 1.0031 -1.1174 0 0 0 0 0 8.73884 0 0 0 0 9.95558 9.92622 0 0 0 A0A8P0P7W5 A0A8P0P7W5_CANLF "ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase" ABO Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] hexosyltransferase activity [GO:0016758]; metal ion binding [GO:0046872] DESHLNRYLLDHKP 1 4.3 0.94254 0.061102 0 0 0 0 0 0 0 0 7.34509 0 0 0 0 0 0 A0A8P0P7Z6 A0A8P0P7Z6_CANLF Fibronectin type III domain containing 1 FNDC1 Canis lupus familiaris (Dog) (Canis familiaris) AFKHDPSYTDCHGRQYVKRTWYRKF;AKSLTYPGETTSALV;APLAPPRHPHR;EALPTIQGYFRQYRQEP;EEAYVIYDEDYEFETSR;GFPIKGPG;GQGLGAGAAAPEGQPSPAVSASQP;LDVPEDINVRVM;LKPRHVKLL;LVENLIPDTMYE;PATVVNDHVSS;VEGSISSF;VEGSISSFPGE;VSPAGAPADHPL;WYECGVSIPGKW;YEFETSRPPTT;YSASYEDFIRNKWSTQAS 17 12.2 0.99262 -0.16905 0 0 0 0 0 7.35852 0 0 0 0 0 0 0 0 0 A0A8P0P824 A0A8P0P824_CANLF "Neural cell expressed, developmentally down-regulated 9" NEDD9 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DGVYDVPLHNPPDAKGSQ;GAVANASCLPEL;LMALVTTDW;LNHAPSQLG;TTDWRCYGYMD 5 8 0.99118 -0.20558 4.56072 11.4507 0 0 0 0 0 10.5256 0 7.80303 8.33825 0 0 0 10.0737 A0A8P0P835 A0A8P0P835_CANLF Otogelin like OTOGL Canis lupus familiaris (Dog) (Canis familiaris) L-arabinose metabolic process [GO:0046373] alpha-L-arabinofuranosidase activity [GO:0046556] AGFYIVIYFPE;ANLAMNFTCA;CNCNLGGD;CNDDCAEGCNC;CNDDCAEGCNCPE;CNDDCAEGCNCPEG;CTFEKQCLGSNLHCLDGCYC;EGCNCPEG;HEDTCNCNLGGDCECLCTS;HLRFCKCCRENGV;ISCCPPTCTFEKQCLGSN;LDCEYYNEGLGEGP;LVVGHSPLSC;PADCIPLIPTEP;PLSCCPQYICECD;PSDYDCCGTCK;SSTICSLDCEYY;TEVMHTLQEPIDC;TSNDMTTSN;VAAYAYKCCQEG;VIIKSIIK;VLISVGDTEI 22 8.8 0.99658 -5.2668 12.8574 11.757 13.0635 7.42978 10.7581 11.1726 13.1118 13.0117 10.4273 12.4706 12.4701 4.51614 13.0368 13.1657 11.9185 A0A8P0P837 A0A8P0P837_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLLPLPVSLSLLFYFRTV;VPLCFFFHLFHWLGI 2 46.5 0.99236 -0.19342 0 9.71168 0 0 0 0 0 7.48977 0 0 0 0 0 0 0 A0A8P0P858 A0A8P0P858_CANLF EvC ciliary complex subunit 2 EVC2 Canis lupus familiaris (Dog) (Canis familiaris) smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] AELRRWEHLIF;AGYLDEEQMEALLERARM;EEQAPEDLVEKELQELERKLEDK;KLHQKLILKRRR;LEKLLWARERKESIL;LERHQQSWREERDH;NEDLALNDQMI;QEKKKLHQKLILKRRRE;QELERKLEDKLA 9 8.7 0.98697 -0.4999 8.73125 5.32124 7.74308 0 8.5838 7.53924 10.4948 7.90141 0 0 0 0 0 10.1579 0 A0A8P0P871 A0A8P0P871_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FYTYEDSDDYDGEEYDV;HTFYTYEDSDDYDGEEYD;TYEDSDDYDG;YEDSDDYDGEEYDVEAHEQ 4 22.6 0.98747 -0.46751 0 0 2.41354 0 0 0 5.37591 0 0 0 0 7.46213 0 0 6.75328 A0A8P0P8B2 A0A8P0P8B2_CANLF Rho guanine nucleotide exchange factor 5 ARHGEF5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085] ATLRTTHAH;FLILPFQRITRLKLLLQNIL;ILPFQRITRLKLLLQNILKRTQP;LMCLLDAWGLE;LTSFSRRLRYNK;LVASEVSSPCDLFPDTCYP 6 5 0.99351 -0.28109 11.6354 0 0 0 0 0 0 7.4245 6.60419 0 0 0 5.85235 0 5.15121 A0A8P0P8C4 A0A8P0P8C4_CANLF BCL9 transcription coactivator BCL9 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070] nucleus [GO:0005634] beta-catenin binding [GO:0008013]; transcription coactivator activity [GO:0003713] PLTMASPAMLGSVESGGPPPP;PPPYQMAPS;QQEYGMGP;TLGENPDGLSQEQLE;TMPGQPTLMSNPAAA;TTAPEPTPAQKTPAKVV 6 6.3 1.0021 -1.4255 10.7175 0 0 7.84373 9.30232 0 8.73897 0 0 7.74906 0 0 0 0 8.26125 A0A8P0P8C8 A0A8P0P8C8_CANLF Zinc finger protein 268 ZNF268 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FCGKTFSSKSYL;FSFNSQLIVHQRIHT;GKAFSFNSQ;IVHQRSHTGMKPYVCS;LGGHLHFV;SNECGKTIN;VIHMRTHTGEKLHE;VLEWLFISQEQSKPTQ;YVSSGEKLHKES 9 11.1 1.0031 -2.3264 9.32071 0 9.37771 0 0 13.5114 9.47537 8.35856 11.2721 0 9.79173 9.8352 0 9.75074 8.01837 A0A8P0P8E5 A0A8P0P8E5_CANLF Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) Canis lupus familiaris (Dog) (Canis familiaris) clathrin coat disassembly [GO:0072318]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] spliceosomal complex [GO:0005681] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] EAFLVVELLPLVVPPLGLPLKRLI;EAFLVVELLPLVVPPLGLPLKRLIK;ETDSLYEGIDLY;ETINWLNKNQ;TAEKEEFEHHR;VLIQVYEGE 6 11.6 0.98843 -0.47604 0 0 10.9725 0 0 0 0 10.1684 11.0451 0 0 4.79971 0 6.63707 0 A0A8P0P8F8 A0A8P0P8F8_CANLF Lysine-specific demethylase (EC 1.14.11.65) KDM3B Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] AAAGGDPGPALRT;KANCPCISRQN;LMEVSVTENSR;QEIFSRGPY;SELKAIRP;TDTQKEVKEMVMGLNV;TEERPTVGPG;VGKRLLLL;VGKRLLLLFA;VLASSGFGAPL 10 6.4 0.93581 0.066126 0 0 0 16.4286 16.6335 0 0 19.9321 0 0 11.3004 11.3162 0 15.4256 16.2313 A0A8P0P8I5 A0A8P0P8I5_CANLF Syntrophin beta 1 SNTB1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] structural molecule activity [GO:0005198] AGPSGGGGGRA;KKGSPVSE;KKGSPVSEIGWET 3 4.9 0.98668 -0.3955 0 0 0 0 0 0 8.47188 0 0 0 7.53784 0 0 11.3667 0 A0A8P0P8I7 A0A8P0P8I7_CANLF Nucleolar and spindle associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) establishment of mitotic spindle localization [GO:0040001]; mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819] YKQPPLQTQE 1 2.7 0.99036 -0.20517 0 0 8.58207 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P8J8 A0A8P0P8J8_CANLF Orexin/Hypocretin receptor type 1 HCRTR1 Canis lupus familiaris (Dog) (Canis familiaris) feeding behavior [GO:0007631] plasma membrane [GO:0005886] orexin receptor activity [GO:0016499] ANRTRLFSVCDEHWADD;FLRYLWRDYL;LVYANSAANPIIYNF;PCGSPKAPSPRS;VSVSVAVLT 5 14.8 1.0033 -1.336 0 0 10.1012 0 0 9.65653 0 0 0 0 0 0 7.44849 7.87817 0 A0A8P0P8L6 A0A8P0P8L6_CANLF Olfactory receptor family 2 subfamily D member 3H OR2D3H Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSYWNIISTV;VSLMDTTFTFQL 2 8 0.95538 0.05044 0 5.85992 0 0 7.97195 0 0 0 0 0 0 0 0 0 0 A0A8P0P8M9 A0A8P0P8M9_CANLF Integrin beta ITGB2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; phagocytosis [GO:0006909] membrane raft [GO:0045121]; plasma membrane [GO:0005886] DTVTVHVIPQ;ECDNVNCERYD;HLPPSFILGPPGRPPLL;INVKKLGGD;VSGCPRGGGRGGPSGHLP;VVLIGILLLAIWKALTHLSDLREFK 6 10.6 1.0021 -1.2426 0 10.5803 0 0 0 0 0 0 8.55209 0 0 7.93882 3.60526 7.76002 0 A0A8P0P8N0 A0A8P0P8N0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DYYCAIGHGSGSSYTYPQCL 1 15.4 0.98256 -0.24826 0 0 11.41 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P8P0 A0A8P0P8P0_CANLF Transmembrane protein 132A TMEM132A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KLASSPECTLKSWPC;PSPSSVDCDQDPLNT 2 2.7 0.98801 -0.37628 0 0 0 0 9.48319 9.69521 0 0 10.0161 0 10.2113 14.2427 10.5468 10.3878 10.3771 A0A8P0P8R2 A0A8P0P8R2_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP18 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] CTYGNHNYRWRETAY;EFRFRFCGKRKLRGR;KRKKEQRRECLS;LASSLQARAEK 4 9.1 0.9867 -0.38503 0 0 0 5.07934 0 0 0 0 0 3.76246 0 8.15649 0 0 0 A0A8P0P8R7 A0A8P0P8R7_CANLF Spastin (EC 5.6.1.1) SPAST SPG4 Canis lupus familiaris (Dog) (Canis familiaris) axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; microtubule severing [GO:0051013]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214] axon [GO:0030424]; centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] KGSGGGGG;SSRAAPAPASASPPAP 2 4.1 0.98722 -0.2333 0 0 0 0 0 8.34873 0 0 0 0 0 0 0 0 0 A0A8P0P8S4 A0A8P0P8S4_CANLF "Spliceosome associated factor 3, U4/U6 recycling protein" SART3 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] RNA binding [GO:0003723] AEQRKRARAEKKALKKKKKTRGA;DIRLVTNRAGK;KTQLLPEV;MGLFGKSAPVDVDP 4 5.3 1.0043 -1.1044 0 0 0 7.68138 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P8V3 A0A8P0P8V3_CANLF Zinc finger protein 451 ZNF451 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DNLGIKNTSIE;HQVHREEISEEEEEQQ;KEFDNGHLLLGHLKRFDHS 3 4.1 0.99288 -0.1668 0 13.9108 5.96516 10.1549 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P8Y8 A0A8P0P8Y8_CANLF Coiled-coil domain-containing protein 22 CCDC22 Canis lupus familiaris (Dog) (Canis familiaris) STPGSHQERLWEQTQP;TELVVEAVV 2 3.4 0.95606 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 9.15487 0 0 A0A8P0P901 A0A8P0P901_CANLF Ig-like domain-containing protein LOC100682670 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ECTPTVYTIY 1 2.5 0.99986 -0.61146 8.78031 0 0 0 0 0 0 0 0 3.14323 0 0 0 0 4.618 A0A8P0P910 A0A8P0P910_CANLF [histone H3]-trimethyl-L-lysine(9) demethylase (EC 1.14.11.66) KDM4A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] CPEEDDMEGLE;TSEPLSCRAQGQ 2 2.4 0.94159 0.085931 0 0 0 0 10.1662 0 6.80465 0 0 0 0 0 0 0 0 A0A8P0P943 A0A8P0P943_CANLF Family with sequence similarity 193 member A FAM193A Canis lupus familiaris (Dog) (Canis familiaris) CSDPDCEGHRCENGV;DDGDESADEDSCSEHSSST;DGDESADEDSC;DGDESADEDSCSEHSSSTS;DPDCEGHRCE;EERLPPAP;EPQQLQNYWSEVRYMVRCIYRQ;ESKVDSPPPSYPTQQ;GAGGGKAG;NQKEGKYCDCCYCEF;NSETMHNGSLEQMEEPETSS;PNCNYRRSCSDDEDVA;PQAHQFISLLLEEY;STSTSTNQ;YCDCCYCEF 15 11 0.99662 -4.3233 0 0 0 0 9.09695 8.42798 9.52052 8.58485 9.02323 5.95401 0 0 8.01714 10.6125 0 A0A8P0P954 A0A8P0P954_CANLF Olfactory receptor OR6E1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EACELQMLIFLALLLTYLVT 1 6.5 0.95012 0.049965 0 9.06695 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P959 A0A8P0P959_CANLF CD72 molecule CD72 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] TDEDEELTYENVQVSSVSGG 1 7.9 0.94901 0.050028 0 0 0 0 0 0 0 0 9.48884 0 0 0 0 0 0 A0A8P0P966 A0A8P0P966_CANLF Transforming acidic coiled-coil containing protein 2 TACC2 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ALADLNSVE;ASFEIPASAIEANGV;DEVSKLSHDVESKVHSSTDSAQ;ELVDDFQTLE;EPGCGPEP;EVPEPLDGGD;GPPEGCLASPVAAPEDWPLI;IEYMEKIGSSL;KPPDGAQGVAMAPL;LEPRCSDSSKSQECKV;LPQQSYNFDPD;PELQAAEGTATPLEPGS;PLDVVCLPTRGREEQASRS;QEAPRAPAAAQPGK;QPLQSEPEASIS;RHEEACLSDVGGSEAADAR;RVDAKEKKQELPTEAE;TASDAIEITAPEGS;TEAEIPCLVPQDPAP;VESTSDTKMRSHP;VGTSDAQGHL;VKETQQEP 22 10 0.997 -4.6195 8.10255 8.07644 10.3066 8.85225 0 8.91217 0 9.05028 9.60411 8.89515 9.46269 9.88976 9.85921 6.41446 12.4215 A0A8P0P970 A0A8P0P970_CANLF Myosin-11 (Myosin heavy chain 11) MYH11 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] ASLGSQLQDTQ;ASRDEIFATA;KTELEDTLDSTAT;RDERTFHIFYYLIAGA;RRSGGRRVIENADG;SKCSDGERARAELND;VGANIETYLLEK;VQEMRQKHTQ 8 5.2 1.003 -0.86344 9.60613 0 0 0 0 9.83862 0 9.78958 0 0 8.80549 0 9.07847 0 0 A0A8P0P976 A0A8P0P976_CANLF U6 snRNA-associated Sm-like protein LSm3 LOC119865916 LSM3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688] RNA binding [GO:0003723] EAYEEIYKSTKWNIPMLFVRGDGV 1 23.5 0.99301 -0.28013 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4456 A0A8P0P978 A0A8P0P978_CANLF Coiled-coil domain containing 192 CCDC192 Canis lupus familiaris (Dog) (Canis familiaris) HKLKHKRKLKKLQTD;HKRKLKKLQ;LKHKRKLKKLQ 3 5.1 1.0043 -1.0519 3.93045 0 0 0 0 7.04614 0 5.84835 0 0 0 0 4.304 0 0 A0A8P0P992 A0A8P0P992_CANLF YME1 like 1 ATPase YME1L1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222] ELEFSKDKILMGP;HQDAFKTGFAEG;IAKRMVTKFGMSEKLG;IESPMHPYSRQTIN;ITAYHESGHAIIAY;VRFRTTTGLDSAVDPVQMKNVT 6 13.7 1.003 -0.79704 0 0 0 0 0 0 0 0 9.96084 0 6.80851 0 7.10643 8.97648 11.9855 A0A8P0P9B2 A0A8P0P9B2_CANLF ADP ribosylation factor interacting protein 1 ARFIP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231] protein domain specific binding [GO:0019904] SALGLRAGSGGGGSGCPR 1 4.3 0.94998 0.053998 0 0 0 0 0 0 0 0 0 0 0 4.9656 0 0 0 A0A8P0P9C0 A0A8P0P9C0_CANLF "EGF like, fibronectin type III and laminin G domains" EGFLAM Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; cell projection [GO:0042995] calcium ion binding [GO:0005509] EPLYATKRRNRKF;RGVLLRLLLLASSLGPRAVS;RVTVAAYSQTV;VLLRLLLLA 4 4.5 1.0027 -1.1806 0 0 0 0 0 0 5.59234 11.3974 0 0 10.7259 0 0 4.99376 0 A0A8P0P9C3 A0A8P0P9C3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] AYHCSKCLEKVP;LVYVLYAVLV;TLESYLDISLDI 3 8.8 0.94624 0.05044 0 10.2055 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P9F6 A0A8P0P9F6_CANLF Calpain 10 CAPN10 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium-dependent cysteine-type endopeptidase activity [GO:0004198] EAGHLQSLY;PVAGTVCH 2 2.7 0.98563 -0.25824 0 0 0 0 0 0 9.54177 0 0 0 0 0 0 0 0 A0A8P0P9H0 A0A8P0P9H0_CANLF Zinc finger protein 384 ZNF384 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] EVHLSTHT;GGGGGGGG;GPGLVITSPSGS;QGGGGGDS;SGISMDTESKSDQL 5 9.9 1.0032 -2.3718 9.84057 0 0 0 0 0 0 0 0 0 0 0 14.8759 8.3411 0 A0A8P0P9I2 A0A8P0P9I2_CANLF Guanylate cyclase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] membrane [GO:0016020] guanylate cyclase activity [GO:0004383] MLPSSVAEALKMGVPVEPEYFDQ 1 17 0.97788 0.046334 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.37936 A0A8P0P9J2 A0A8P0P9J2_CANLF Transporter SLC6A4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] antiporter activity [GO:0015297] HRNGCISIWRKICP;ITWTPHSTSPA;LEGVITAVL 3 5.9 0.98673 -0.40955 0 9.27051 11.1729 3.49454 0 4.37156 0 0 0 0 4.47132 0 0 0 0 A0A8P0P9J4 A0A8P0P9J4_CANLF Hedgehog acyltransferase like HHATL CCDC13 Canis lupus familiaris (Dog) (Canis familiaris) AEVERDRLTEFVTV;LTWPSLPSPHGAS;RMLEDEIAH;TNLKMSDLRNQIQT 4 7.1 1.0016 -0.74323 0 0 0 0 7.12866 0 0 0 0 0 8.25243 0 0 0 0 A0A8P0P9L6 A0A8P0P9L6_CANLF Matrix extracellular phosphoglycoprotein MEPE Canis lupus familiaris (Dog) (Canis familiaris) biomineral tissue development [GO:0031214] VEEQRQEE 1 1.5 0.98643 -0.23191 0 0 0 0 10.1475 0 0 0 0 0 0 0 0 0 0 A0A8P0P9M5 A0A8P0P9M5_CANLF Ubiquitin like 7 UBL7 Canis lupus familiaris (Dog) (Canis familiaris) LFEGLSDDEDDF 1 3.2 0.98809 -0.22753 0 0 0 0 0 0 0 0 0 0 10.1288 0 0 0 0 A0A8P0P9M8 A0A8P0P9M8_CANLF "MFSD2 lysolipid transporter B, sphingolipid" MFSD2B UBXN2A Canis lupus familiaris (Dog) (Canis familiaris) QPLSDDRQRN 1 4.1 0.99986 -0.61146 0 0 0 0 0 0 8.61405 0 0 0 0 0 0 0 0 A0A8P0P9P1 A0A8P0P9P1_CANLF "MFSD2 lysolipid transporter A, lysophospholipid" MFSD2A Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate transport [GO:0008643] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] symporter activity [GO:0015293] DPGVWPPAPTQ;KFTLKLLVTIAPIVLILLGLL;LLVTIAPIVLILLGLLL;TLKLLVTIAPIVLILLGLLL 4 5.5 0.99182 -0.066211 0 0 0 0 0 8.93552 3.95801 0 0 0 0 8.16757 0 3.54992 0 A0A8P0P9P8 A0A8P0P9P8_CANLF Splicing factor 3b subunit 1 SF3B1 Canis lupus familiaris (Dog) (Canis familiaris) spliceosomal complex assembly [GO:0000245] nucleus [GO:0005634] mRNA binding [GO:0003729] AATELEDDDDDY;PERLDPFADGNSFPLFYKFSGIYL 2 23.4 0.99182 -0.29131 0 10.4917 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P9Q0 A0A8P0P9Q0_CANLF C2H2-type domain-containing protein ZNF281 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GGDGGGSHG;GGGGGGGG;HTGERPFQCS;QELASQIDPQKDIEPRTTYQIENF;TVSSSGGI 5 7.5 1.0031 -1.0288 0 0 0 0 0 0 0 8.75248 0 9.44485 0 0 0 0 8.82193 A0A8P0P9Q1 A0A8P0P9Q1_CANLF Chloride intracellular channel protein CLIC5 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; cytoplasm [GO:0005737] chloride channel activity [GO:0005254] KNTKQQNNAALE;SPANFTIQEGRAFVARNSANE 2 8.1 0.99067 -0.53756 0 0 0 0 0 0 0 0 0 0 0 0 10.86 0 0 A0A8P0P9R8 A0A8P0P9R8_CANLF E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin) LTN1 Canis lupus familiaris (Dog) (Canis familiaris) rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116] cytosol [GO:0005829]; RQC complex [GO:1990112] metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630] ATYTIEDIVIELIIQLPSNYPLGSI;CLLPENELDSL;DEQLFNHLAETLSSW;FQNAMLKPMC;IFLTGFCEMLQKMNITY;LLQLLFSRSMEH;LPKKACRTC;LSNKDPKTFFTE;LSSWEAKVDVEKDDKTAHS;MVRLWWNSSEKRVFN;QVLQKPKNSLKLNKKKVGKVR;SCLQTRSIDDG;TYTIEDIVIE;VLRKLSKKDV 14 10.4 1.0031 -2.367 0 9.8614 11.2676 0 5.09145 6.3147 3.76765 11.0714 10.9771 9.97985 9.27282 4.852 11.377 10.5631 9.15163 A0A8P0P9S9 A0A8P0P9S9_CANLF 40S ribosomal protein SA LOC106559170 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] small ribosomal subunit [GO:0015935] structural constituent of ribosome [GO:0003735] VISSRNTGQIEKEE 1 8.2 0.59512 0.38923 14.1346 13.9157 0 0 0 10.0417 0 0 0 10.3848 0 0 0 0 0 A0A8P0P9V0 A0A8P0P9V0_CANLF Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) MED23 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GSPAPQSNQVPVSLP;HAFAMTCIW;IEEAFPGMFMD;LSQESHEQCIQW;NYMDPICDFLYHMKY;PYLPIYFGN;RDLLKVILEKILTI 7 6.4 1.0026 -1.163 0 0 13.6558 0 0 0 0 12.3444 0 0 0 0 7.2949 0 10.044 A0A8P0P9V6 A0A8P0P9V6_CANLF Coiled-coil domain containing 102B CCDC102B Canis lupus familiaris (Dog) (Canis familiaris) IKEESKSPNNKDRLIYQ;QELGQKEEEV;TENCTLKS;WDKREMLETEKQGLE 4 10.5 0.99964 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.3458 A0A8P0P9X3 A0A8P0P9X3_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] KSYLSIVTLNVNGLNDP;MNEKGEITTNT;PSICCLQETHFRQ 3 6.3 0.99354 -0.1704 10.6966 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0P9Y2 A0A8P0P9Y2_CANLF SH3 domain binding protein 1 SH3BP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] ANYFIHLMEIQ;EVNKMTPSNIA;KRKKLPLMALSTTMAE;VGVVEALIQ 4 6.8 1.0022 -1.0191 0 8.92766 7.62578 0 0 0 9.5462 0 0 0 0 0 0 0 0 A0A8P0P9Z4 A0A8P0P9Z4_CANLF Kinectin 1 KTN1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018]; protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] kinesin binding [GO:0019894] EHLEMELEKAEIERSTYV;EVLAKQKREQKLIPTKTDKK;LQQEEVQKKNAEQ;NCGGGASE;NKDIENLRREREH;QLQEAERRWEEVQSYIRKRTAEHEA;VLDKREVIDL;VLEHKLKEADEMH;VLPAPPRPPGLRPRLRRIRVLQ 9 9.8 1.0031 -0.78957 9.8104 13.0912 9.12794 0 0 0 6.64443 8.7895 7.50279 0 0 11.2616 0 0 6.93499 A0A8P0PA02 A0A8P0PA02_CANLF Zinc finger MYND-type containing 8 ZMYND8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] EGDWFCPECE;EVNTETLNKSSQ;IPDQAGIGHGRKHPKDPGSTERTAQ;LGLDSDSESELVI;SPVKKQRPLLPKE;TAGSQSPPETPLLTRSSSQTPTAG;VAADIAKYTSKMM;VIDLGEDHSG;YCWVCHREGQVLCCELC 9 11.1 0.97864 0.035538 0 9.30241 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PA07 A0A8P0PA07_CANLF Embigin EMB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SGNVNSVNVTWKKGNKQLENIHTN 1 7.4 0.97355 0.041303 0 0 0 8.8666 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PA10 A0A8P0PA10_CANLF Small ribosomal subunit protein uS17 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] DCSHYIRK 1 7 1.0042 -1.1044 8.01698 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PA13 A0A8P0PA13_CANLF Neuron navigator 1 NAV1 Canis lupus familiaris (Dog) (Canis familiaris) neurogenesis [GO:0022008] ATP hydrolysis activity [GO:0016887] APFQYRLQTDQ;ARESAEGGEGLSSSPWSSP;DSDPLVSRSHS;GGGGGGGA;GGGGGGGG;GGPAAGAK;PDLHPPSSASGSPLPSCFT;PGGGGGGG;PSSPKLQHGSTETASPSI;SLEMTCYDSDDAN;TDLSPMDGISTCGPKEEVTLRVV;VPHTRLFH 12 6.5 1.0015 -2.6543 0 0 10.0736 9.96881 0 7.46238 11.6962 9.56695 0 0 0 0 0 0 6.99628 A0A8P0PA25 A0A8P0PA25_CANLF Oxysterol-binding protein OSBPL11 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] CPEERCSHQTTPS;EINADDEVEDMCDN;QYKLRATDAKERQHW;SGNSPISQRRPSQNAI;VPEEQCVEESG 5 9.5 0.98684 -0.38019 10.032 0 0 8.84828 9.8389 0 0 0 0 0 0 0 0 8.44083 0 A0A8P0PA36 A0A8P0PA36_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVEALATLEMVGR 1 13.5 0.98928 -0.21849 0 0 0 0 0 0 0 0 0 0 0 0 9.89642 0 0 A0A8P0PA40 A0A8P0PA40_CANLF L-lactate dehydrogenase B chain Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] mitochondrial inner membrane [GO:0005743] "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" SADNLVGHPERP 1 7.1 0.95392 0.05044 0 0 0 7.19781 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PA66 A0A8P0PA66_CANLF Creatine kinase B-type (EC 2.7.3.2) (Creatine kinase B chain) Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] EQGWAIDDLVPAQK;HETFPKVL 2 7.1 0.98563 -0.44205 0 0 10.0991 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PAB0 A0A8P0PAB0_CANLF Olfactory receptor OR51A25 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVNILYGLYVVLST;VLWFDYRH;VLWFDYRHIGFNA 3 8.3 1.0028 -0.97964 0 0 0 0 9.04917 0 0 0 0 0 0 0 0 9.86737 0 A0A8P0PAC6 A0A8P0PAC6_CANLF TOX high mobility group box family member 4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] SPQPRCVRSS 1 3.6 0.98801 -0.26464 0 0 0 0 0 0 0 0 9.28857 0 0 0 0 0 0 A0A8P0PAC9 A0A8P0PAC9_CANLF Solute carrier family 7 member 2 SLC7A2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] L-arginine transmembrane transporter activity [GO:0061459] GVSAALTLMMPYYLLD;IVTSLLVCFMAYFGVSAAL;PKTGSAYL;PYGFAGTLAGAATCF;VGELWAFITGWNLILSYGTS 5 11 0.987 -0.50269 10.763 0 7.23802 0 0 0 0 0 7.05365 0 0 0 0 10.5677 0 A0A8P0PAD6 A0A8P0PAD6_CANLF Clathrin heavy chain CLTC Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439] clathrin light chain binding [GO:0032051]; structural molecule activity [GO:0005198] DLELINVCN;ESKDTELAEELLQW;LDRAYEFAER;NIEMKSKMKAHTM;TETQPIVYGQPQLMLT;TWKEVCFACVD;VGYTPDWIFLLRNVMRI;VQDEEPLADITQI 8 6.4 1.0019 -1.2649 0 0 8.12975 0 0 0 0 8.29172 14.1549 0 10.6688 0 0 13.8025 0 A0A8P0PAE5 A0A8P0PAE5_CANLF Heat shock protein 90 alpha family class B member 1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] LQQSKILKVICKNIV;SQSGDEMTSLSEYV 2 8.2 0.98932 -0.26403 0 0 0 0 0 8.46046 0 0 0 0 0 0 0 0 0 A0A8P0PAG7 A0A8P0PAG7_CANLF Chloride channel protein CLCNKA Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] voltage-gated chloride channel activity [GO:0005247] ESENKSKQNEML;GYFMPIFIFG;RCLQDILAGGCPLEPV 3 5.9 1.0019 -0.68946 0 0 0 0 0 0 0 0 0 0 0 0 0 9.07957 10.9188 A0A8P0PAH7 A0A8P0PAH7_CANLF Abhydrolase domain containing 15 ABHD15 Canis lupus familiaris (Dog) (Canis familiaris) LALALALLLAALALLGLLAQRLR 1 4.9 0.97789 0.046253 0 0 0 0 0 0 0 0 0 0 0 3.57204 0 0 0 A0A8P0PAL2 A0A8P0PAL2_CANLF Nucleoporin 210 like NUP210L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CLIKVRPQS;FKFQVMSEGGPQPQ;FQVMSEGGPQPQSII;HLLLDLNMDKQ;IVSRTRELYVDDSPLEL;PFGREPGRVPFLLEAQRGCYTWH;PQHNKQLIPV;PVAVEHAIE;PVKFPIIH;TLVEEQDEYSENYIL;VEHAIEPDTHLTFV 11 7.6 0.99717 -3.4576 0 0 10.8471 0 0 11.8098 9.09336 7.7763 7.31406 0 0 0 0 0 10.7945 A0A8P0PAL9 A0A8P0PAL9_CANLF PIF1 5'-to-3' DNA helicase PIF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] PSLVRTLFV 1 2.7 0.98572 -0.24599 12.1029 0 12.0185 0 0 0 12.7718 12.8678 12.9734 12.483 0 12.7001 12.3125 0 12.42 A0A8P0PAM8 A0A8P0PAM8_CANLF Trafficking protein particle complex subunit 14 TRAPPC14 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] alpha-tubulin binding [GO:0043014] ASTSPQTSTYHLRKTSQ;EPRTLVVI;KTHGGDLFRAQ;LSPQQPCHPGIMGP;PGGGDPGGGALFRGCS;RGGAGPGA;VLRGIWRDQWAMVDFMGYFRGPTGY;VVGSVLAICILYIRVSWLD 8 10.3 1.0027 -0.9801 8.79191 0 0 0 0 9.13353 0 13.7178 0 0 10.6183 0 0 10.0932 0 A0A8P0PAP8 A0A8P0PAP8_CANLF Uroporphyrinogen decarboxylase (EC 4.1.1.37) UROD Canis lupus familiaris (Dog) (Canis familiaris) heme biosynthetic process [GO:0006783] uroporphyrinogen decarboxylase activity [GO:0004853] DTFLRAAWGEDTDYTPVWCMR 1 6.5 0.95006 0.049792 0 0 0 0 0 0 9.60561 0 0 0 0 0 0 0 0 A0A8P0PAQ7 A0A8P0PAQ7_CANLF Cleavage and polyadenylation specific factor 3 CPSF3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] ECEEGSEDDESLREMVELAAQ;GRAQELLLILDEYWQNHPEL;LVHGEQNEMAR;VIIAGYCVEGTLAKH 4 10.4 0.98756 -0.33423 0 0 0 0 6.41637 9.52525 0 0 0 0 0 0 0 0 10.6712 A0A8P0PAR8 A0A8P0PAR8_CANLF Cation channel sperm associated auxiliary subunit beta CATSPERB Canis lupus familiaris (Dog) (Canis familiaris) CatSper complex [GO:0036128] EPFTQWLPCL;FEAALAPQYITLK;LDNVREPILQ;PDMGFEAALAPQYITLKEMIFYAY;SKIGSVSDNIFTLYYDHMGFI;SLGLFVSGDLRYPSSSVLT;VGEEHTDLSV;WFLYNLGHRNGRIWTI;YHSFYTSDITFVSQSGN 9 11.8 1.001 -0.94413 9.72649 5.71565 0 0 10.9486 0 7.3147 0 0 8.56708 0 0 8.09107 8.56716 0 A0A8P0PAS2 A0A8P0PAS2_CANLF Solute carrier family 9 member C2 (putative) SLC9C2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sodium:proton antiporter activity [GO:0015385] FVFLYIFQAAMKIISLKRKYFHQYW;IPFIKLIIPLLI;LKTRQAIRRVIAKALKNLTFLWSRG;MVYMTFYIGESFG;PFIKLIIPLLINIVDVQIKKRLRL;PLLINIVDVQIKKRLRLMYSITK;RIIRFIPFIKLIIPLLINIVDVQ;VICREGEMPQGIYLIISGMAILHS;VLIEFFKERAKLAYFDYGDVICREG;YTVVNGHFIMLVC 10 13.9 1.0039 -0.82837 6.43249 0 0 0 12.8511 0 5.49326 0 6.04546 0 6.63032 4.29234 14.142 10.2751 0 A0A8P0PAS5 A0A8P0PAS5_CANLF Ribosome biogenesis protein NOP53 NOP53 Canis lupus familiaris (Dog) (Canis familiaris) ribosomal large subunit assembly [GO:0000027] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] AFQEMCQGLLEESDGEE;KFKRKYKVKLVEKRAFREI;LEVDQFLEDV;RSQKRSLLLKKPLRVD;SQKRSLLLKKPLR 5 13.7 0.95279 0.04941 0 0 0 0 0 0 6.49954 0 0 0 0 0 0 0 0 A0A8P0PAT5 A0A8P0PAT5_CANLF Acid sensing ion channel subunit family member 4 ASIC4 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] membrane [GO:0016020] sodium channel activity [GO:0005272] GGEEGAHSSRGGT;GGGSGAHR;GVAPSQDPPSDLHR;HQLADMLKSCNFSGHH;LVLDVFFEALTSEAM;VGEPAACS 6 11 0.9986 -2.9963 0 8.75582 5.55836 0 0 0 0 0 0 0 9.50098 0 0 14.6455 0 A0A8P0PAT9 A0A8P0PAT9_CANLF Glutamate receptor GRIK2 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] ligand-gated monoatomic ion channel activity [GO:0015276]; signaling receptor activity [GO:0038023] EYVESGPM;GVGTPMGSPYRDKIT;IGTWDPASG;LAYLGVSCVLFVI;LDVISLKEE;NGQWNGMVREL;VSLYPDFSSLSRA;WRGNGCPEE 8 10 0.99751 -3.7625 8.5749 0 0 7.9031 0 0 5.75256 10.3078 0 0 0 0 0 0 0 A0A8P0PAU1 A0A8P0PAU1_CANLF "Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (Telokin)" MYLK Canis lupus familiaris (Dog) (Canis familiaris) muscle structure development [GO:0061061] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; protein kinase activity [GO:0004672] DTGTYTCE;EPQVTWHRNG;GVAELHIQDALPEDDGIYT;IEKALPEDRGFYK;IQEVFPEDTGTYTCEAWNS;ISNAKPAE;KVRGYPEPQVTWHRNGQ;LDLKPENIMCVNKTG;LVKRLAVMEVAP;RAIGRLSSMAMI;SGLSPFMGDNDNETLA;VIHAVREEDQGKYT;VINYEPIGY;VLKDCAVIEGQDFVLQCSVQG;WTLLVKRL 15 9.1 0.95807 0.051237 11.7985 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PAV7 A0A8P0PAV7_CANLF NCK associated protein 5 NCKAP5 Canis lupus familiaris (Dog) (Canis familiaris) DYLPPPSSAKP;EALNELHIGSSDEKSPS;EEKVMLCIQENV;FVYDTDSHDDAD;PLERKLYPSVQP;SRPKTFSFIKQQRVVKR;SRSLHLEYMDSNKYI;THEKGLKTRLPVGLKVLMKSP;TSEQLPEWGSE;VGLKVLMKSPQLLRKSST 10 7.2 0.9528 0.053874 0 0 0 0 0 4.49659 0 0 0 0 0 0 0 0 0 A0A8P0PAV9 A0A8P0PAV9_CANLF Zyg-11 related cell cycle regulator ZER1 Canis lupus familiaris (Dog) (Canis familiaris) IVQLHKLRIE;RSFSHTLVSLS;RVIVQLHKLRIEPSK;VLSHIMFDGP 4 5.1 0.99432 -0.55758 0 0 0 0 0 5.65131 0 0 0 0 0 0 0 0 0 A0A8P0PAW1 A0A8P0PAW1_CANLF Ig-like domain-containing protein LOC100855640 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DNGIYHCYFQEGR;EELRKCAMPGGS;THWLLQLTSLFPLQTGDDPCY 3 16.8 0.98965 -0.19648 0 0 0 0 0 0 0 0 0 0 0 0 9.33107 0 0 A0A8P0PAY5 A0A8P0PAY5_CANLF DNA-binding protein RFX2 (Regulatory factor X 2) RFX2 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ASVALCPSAAAQAPV;DPDAHSLGEPLVKRER;KASSGDGP;LQWLLDNYETAEGVSLPRSSLYNH;WLSFWNSK 5 10 1.001 -0.93369 0 0 12.2903 7.7339 0 0 0 0 9.44108 0 0 0 0 0 0 A0A8P0PAZ4 A0A8P0PAZ4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of actin filament polymerization [GO:0030833] small GTPase binding [GO:0031267] ALSSADLLE 1 9.7 0.94061 0.070375 0 0 0 0 0 9.8035 0 0 0 0 0 0 0 0 0 A0A8P0PB18 A0A8P0PB18_CANLF G protein signaling modulator 2 GPSM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTPase regulator activity [GO:0030695] SAIYSQLGNAYFYLHD 1 3.1 0.95708 0.049233 0 0 0 0 0 0 0 0 8.56083 0 0 0 0 0 0 A0A8P0PB21 A0A8P0PB21_CANLF Atos homolog protein A ATOSA Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GLHREDTLDE;ISISNTKFSFLEDSSEGTNLIPK;LIHCDPSTSHVPG;QENENVRKCKEPFSI 4 5.6 0.99387 -0.054106 0 8.72393 0 6.24654 0 0 0 0 12.9404 0 15.2423 0 0 0 0 A0A8P0PB29 A0A8P0PB29_CANLF Interferon induced protein with tetratricopeptide repeats 3 IFIT3 Canis lupus familiaris (Dog) (Canis familiaris) response to other organism [GO:0051707] DTFQKVLYMKNIDNHLQQQIHYHYG;YYHMGRLAEAQAYLDK 2 8.9 0.98018 0.035538 0 0 0 0 0 0 0 0 9.1404 0 0 0 0 0 0 A0A8P0PB33 A0A8P0PB33_CANLF PDZ and LIM domain protein 2 PDLIM2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] GGRSRSPGRALPRVGRRRRRLLTLP;GPTAANRFS;PSSPRLSAD 3 6.3 1.0024 -1.0201 0 12.1693 0 0 5.12106 7.67051 0 0 0 12.1837 0 0 0 0 0 A0A8P0PB35 A0A8P0PB35_CANLF Sorting nexin SNX18 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; mitotic cell cycle [GO:0000278]; protein transport [GO:0015031] cytoplasmic vesicle membrane [GO:0030659] phosphatidylinositol binding [GO:0035091] FHQIRNVYWTWYLKKENARLRN;IAFTGDAYDAIGEL;QASQGSDDDWDDEW 3 8.1 0.9919 -0.20695 9.72071 0 0 0 6.56175 0 0 0 0 0 0 0 0 0 0 A0A8P0PB83 A0A8P0PB83_CANLF glutaminase (EC 3.5.1.2) GLS2 Canis lupus familiaris (Dog) (Canis familiaris) glutamine metabolic process [GO:0006541] glutaminase activity [GO:0004359] DLYFQLCSVEVTCESG;FTSHVDRIFEDAKEL;GVDMMAALDLYFQLCSVEVTCE;MVNAGAIVYLNKMA;VDRIFEDAKELTGGKVAAY;VEVTCESGSVMAA;VLSAEAVRNTLSL 7 13.6 0.98678 -0.39664 0 0 9.61917 6.74846 0 0 9.66681 0 0 0 9.60244 8.32544 8.35601 9.66413 8.851 A0A8P0PB88 A0A8P0PB88_CANLF Kelch like family member 13 KLHL13 Canis lupus familiaris (Dog) (Canis familiaris) IVQKYDPDKDEWHKVFDLPESLGG;SHLYCCSSKEECSE;VGGYSWNNRCM 3 7.6 0.87374 0.13756 0 0 0 0 8.09745 4.42116 0 0 12.2948 0 0 0 0 0 0 A0A8P0PB92 A0A8P0PB92_CANLF Signal induced proliferation associated 1 like 2 SIPA1L2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] GKDFMDTAGERSPS;PATSLTASNSTEGG;TLWESRSQTSYE;VDTSVKFSF;YRAQLDNKT 5 3.5 0.99364 -0.074328 0 8.46638 0 9.2949 0 0 0 0 0 10.4035 10.084 10.6171 10.3551 0 10.1308 A0A8P0PBA4 A0A8P0PBA4_CANLF Inositol-1-monophosphatase (EC 3.1.3.25) IMPA2 Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol phosphate biosynthetic process [GO:0046854] inositol monophosphate 1-phosphatase activity [GO:0008934]; metal ion binding [GO:0046872] AADLVTETDHLV;GVIYHCTEERLYTGRR;SGGPLDLMSCRVVAAGTRE;SHREHTGKEEAG 4 19.9 0.98807 -0.49147 0 0 0 0 0 0 0 10.365 0 0 0 0 0 6.28394 0 A0A8P0PBB3 A0A8P0PBB3_CANLF DM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] QEHFCPFQACDCHKCAFFSEHRSVL;YSPIQDSPPS 2 9.6 0.99645 -0.57592 0 0 7.92636 0 0 0 0 0 0 0 0 0 0 0 6.58128 A0A8P0PBB5 A0A8P0PBB5_CANLF Uncharacterized protein LOC491385 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] HLRTHSPETHSECNT;NVSVGPYKHSVLEK;SSLTQHQRIHTGE 3 5 0.99205 -0.17748 2.66107 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2074 A0A8P0PBC4 A0A8P0PBC4_CANLF V-set and transmembrane domain containing 4 VSTM4 TMEM273 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASMLRAFLLLLEVCGALNVTV 1 7 0.98527 -0.24044 0 0 0 0 0 9.87513 0 0 0 0 0 0 0 0 0 A0A8P0PBD3 A0A8P0PBD3_CANLF Marker of proliferation Ki-67 MKI67 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATAGHTCSGLPGHSSVDTSNF;ITDPPGGN;LDLEEEPSAL;SEDMSITSGSESM 4 1.7 1.0033 -1.1044 0 0 0 0 0 0 0 6.58343 0 0 0 0 0 0 0 A0A8P0PBF2 A0A8P0PBF2_CANLF Interleukin 17 receptor C IL17RC Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] membrane [GO:0016020] interleukin-17 receptor activity [GO:0030368] ITLNHTDLFPCLCIQVWP;LLEVQVPAALV;LQVTVDLWSRR;NAFLQAQVVLSFQAYPTARCVL;WSRRELSAQGPLAWFHAQ 5 10.9 0.98671 -0.38595 0 0 8.42042 0 0 0 10.8152 10.9117 0 0 8.14782 0 0 0 0 A0A8P0PBF8 A0A8P0PBF8_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP49 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270] EKIGVHVVF;IPFSQRKLTK;VSPFAMLH 3 4 1.0032 -1.0259 0 0 11.9283 0 0 4.97687 10.7148 0 10.9503 0 0 0 0 0 0 A0A8P0PBI2 A0A8P0PBI2_CANLF Zinc finger RANBP2-type containing 3 ZRANB3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; endonuclease activity [GO:0004519]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] AWDSRFCSVKCQEEFWIRSNN;GVCVPFLNPCIAQA;HQLLSDIMIRRLK;IRRLKNDVLTQLPP;SCEELKNEILFTHFEKEKQHDIRSF;TPALGRPEELF 6 9.3 1.0018 -0.74233 0 0 0 0 0 0 8.05333 0 0 3.20491 0 0 9.73848 0 0 A0A8P0PBJ2 A0A8P0PBJ2_CANLF Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) KATNA1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule severing [GO:0051013] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; midbody [GO:0030496]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] AADIERYEKW;EVWSLPVPVE;KVRRGMLLASRRAPL 3 5.9 1.0041 -1.1013 9.14863 0 9.77568 0 0 0 0 10.8304 0 0 0 0 0 0 0 A0A8P0PBL1 A0A8P0PBL1_CANLF Trafficking protein particle complex subunit Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008] DSYAPRAEAEKTSSHPLDLLL;EAEKTSSHPLDLLLKLHDERVLA 2 23.6 0.93392 0.097004 0 0 0 0 0 0 0 0 6.64976 0 0 0 10.8853 0 0 A0A8P0PBM9 A0A8P0PBM9_CANLF Peptidase S1 domain-containing protein PRSS33 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] WRCCSCAGRCPSAPA 1 6.4 0.95662 0.053877 0 0 0 0 0 0 0 0 0 0 0 0 0 8.65331 0 A0A8P0PBN2 A0A8P0PBN2_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] AELKRISQKKLKKQKL 1 13.2 0.9566 0.049233 0 0 0 4.39328 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PBP0 A0A8P0PBP0_CANLF Junctophilin JPH4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; plasma membrane [GO:0005886] GSREEGKYKRN;GVCTGPGA;SPELPSSPASSRQPW;WGGPSEQAEELAGYE 4 7.8 1.0021 -1.2969 0 0 0 0 0 7.12536 0 0 11.4012 0 6.96832 0 6.25799 0 0 A0A8P0PBP5 A0A8P0PBP5_CANLF Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) NSRP1 Canis lupus familiaris (Dog) (Canis familiaris) "regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" HNLLKAVEIRKKEQ;KERHENSDKYRDREQQEINVQS;KKLQERAEEEEREKRAAALE;VGENPDADSDFDANSEDDEMEENNK 4 15.9 0.99745 -0.10503 0 0 7.44444 0 0 0 13.2218 0 0 5.54535 0 0 0 3.95466 0 A0A8P0PBQ4 A0A8P0PBQ4_CANLF Nuclear receptor subfamily 4 group A member 1 NR4A1 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954] cytosol [GO:0005829]; nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] GPASGTSGG;KYICLANKDCPVDK;PKASGHPQPPAFFSFSPPT 3 7 1.003 -0.97701 0 0 0 0 8.5988 0 0 9.99958 0 0 0 8.20217 0 0 0 A0A8P0PBQ9 A0A8P0PBQ9_CANLF Nidogen 1 NID1 Canis lupus familiaris (Dog) (Canis familiaris) cell-matrix adhesion [GO:0007160] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] GVWVFEIGSPATASGV;IDSVYVTTNGII;LPTERHPGPPT;PEDGLQFYTTFSKKDENQVPAVVAF;TRSFQPPAET;YHYSRGVITS 6 7.6 1.0028 -1.1413 0 0 0 0 12.3049 0 11.224 9.87929 10.2273 0 0 0 0 0 0 A0A8P0PBR3 A0A8P0PBR3_CANLF Hedgehog acyltransferase like HHATL CCDC13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEVERDRLTEFVTV;HCVSLYVASLLGQPWLCLG;LTWPSLPSPHGAS;TTLWLGPCDIV;VTYCGVQLVKERERTMALE 5 10.7 0.93008 0.10765 0 0 3.89142 0 9.07074 0 9.98598 9.62533 0 0 0 0 0 0 9.1726 A0A8P0PBS3 A0A8P0PBS3_CANLF Zinc finger SWIM-type containing 8 ZSWIM8 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] GAGSGGKG;GGGGGGSG;GGKAKALG;ISEAESLCQNWRGWRKQSA;VEACYFNWEEAYPLPGVTYSGTDR;VGMFALELQRPP;VYPEVLFEVAHQWF;WYLDESTLTDNIKKTLHKFC 8 6.5 0.99889 -2.9409 10.1876 0 0 0 0 10.4983 0 0 0 8.85901 0 8.61982 0 9.19155 0 A0A8P0PBS8 A0A8P0PBS8_CANLF Carbohydrate sulfotransferase (EC 2.8.2.-) CHST11 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate biosynthetic process [GO:0016051] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] AGVGSYLK;LDFLMFNYSVP;SANLKTLNQYSIPEI;SIPEINHR;TQLYEVYKLDFLM 5 14.2 1.0031 -1.7073 0 11.1645 0 0 0 5.19472 8.23664 0 0 3.48065 0 0 12.9066 0 0 A0A8P0PBU3 A0A8P0PBU3_CANLF Y-box-binding protein 1 (Y-box transcription factor) LOC474472 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676] TTGSGAGSG 1 4.4 0.99206 -0.27195 8.2695 8.18299 0 0 0 0 8.86137 9.14542 8.87784 0 0 0 0 0 0 A0A8P0PBV2 A0A8P0PBV2_CANLF Golgi integral membrane protein 4 GOLIM4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] DEAEDDPENGREPQDHGPHEA;EEEEEDGV;GIQEEEGGAYERDNHH;PYEEEEEEEEDGVG;SGSAACQRASVSR;VGAAEKSQRR;VKTQVAEYKQLK;YNLREENR 8 8.1 1.0034 -1.5451 10.8803 0 8.7494 7.13175 0 0 0 0 0 10.7322 0 11.0173 0 0 0 A0A8P0PBV9 A0A8P0PBV9_CANLF Regulator of microtubule dynamics protein 1 (Protein FAM82B) RMDN1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule [GO:0005874]; spindle pole [GO:0000922] EALGYFHRAEQGKTYLK;IWCYTFAEMPWYQRRIAKMLF;QAAVVHATAKVEEI 3 21.6 0.99368 -0.12117 0 0 0 0 8.98536 8.33454 0 11.2901 0 0 0 0 0 0 0 A0A8P0PBW4 A0A8P0PBW4_CANLF TATA-box binding protein associated factor 5 like TAF5L Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] QESIKRVK;SESGCANIVSAAPCQAEPQQY 2 7.3 0.98923 -0.21472 0 0 0 0 3.96975 10.7555 0 0 0 0 0 0 0 0 0 A0A8P0PBW5 A0A8P0PBW5_CANLF Calsyntenin 3 CLSTN3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EDSSDSEAA;LQLCEQAAWWLVQAAV;TLRRIPLL 3 8.8 1.0014 -0.74458 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7983 0 A0A8P0PBZ9 A0A8P0PBZ9_CANLF Beta-defensin DEFB128 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular region [GO:0005576] KLFLVLII 1 11.4 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 7.74093 0 0 0 0 0 A0A8P0PC22 A0A8P0PC22_CANLF Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] IL16 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] cytokine activity [GO:0005125] APASRERPG;FHSSVQLADTSEAGRGSVPDL;KYPDPFETSLGQSKEGIFHSS;PVPTHQPKATDQ;TSSREKSG 5 5.2 1.0025 -1.1326 0 0 12.5754 0 10.753 0 0 0 9.64024 0 0 0 7.76713 0 0 A0A8P0PC35 A0A8P0PC35_CANLF Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) EVL Canis lupus familiaris (Dog) (Canis familiaris) stress fiber [GO:0001725] SGGSSPSGTS;SLHFEALLPTGD 2 4.3 1.003 -0.85602 0 0 0 0 0 0 9.29494 9.29156 9.57628 0 0 0 0 0 0 A0A8P0PC37 A0A8P0PC37_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;KTQINKIMNEKGEITTNAKE;MDAFLESHKL;PSICCLQETHFRQ;TNAKEIQTLLKTYYEQ 5 7.2 0.93292 0.099301 9.86929 0 0 7.27342 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PC92 A0A8P0PC92_CANLF Baculoviral IAP repeat containing 3 BIRC3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981] ELKYDHSCELYRMSTYS;EQLRRLQEERTCKVCMDK;SAFISHIFNEHI;STHAQSPGLERSSY;VGHSDDVK 5 11.1 1.0026 -1.1811 13.6691 9.83979 0 0 0 11.8139 0 0 0 0 0 0 0 0 0 A0A8P0PCA1 A0A8P0PCA1_CANLF Caspase 9 CASP9 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] cysteine-type endopeptidase activity [GO:0004197] DLGVSLGSAS;DSEPDAVPFQE;EDLRGKDPSKLTPGKLA;LRMSRQAVKQNPE;LTPGKLAPVVLGPAELQPQ;QVVRPSVPRPTD 6 14.7 0.98672 -0.32825 11.302 9.54274 6.1479 0 0 0 10.181 0 0 0 10.515 0 10.2947 0 0 A0A8P0PCA8 A0A8P0PCA8_CANLF Coagulation factor XIII A chain F13A1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] FNTFLRCLGIPA;LPTVELQGGPVPR;NASNAAEDDLPTVEL;NASNAAEDDLPTVELQGGP;NASNAAEDDLPTVELQGGPVPR;SETSGPAFGGRRA;SNAAEDDLPTVEL;SNAAEDDLPTVELQ;SNAAEDDLPTVELQGGP;SNAAEDDLPTVELQGGPVPR;VGFGGWQAVDSTPQE 11 9.3 0 177.62 12.5616 12.629 13.7191 12.0628 12.0924 12.4974 14.3345 14.2007 13.4136 13.1997 13.6556 13.4985 13.5371 12.4894 13.5462 A0A8P0PCB4 A0A8P0PCB4_CANLF ALMS1 centrosome and basal body associated protein ALMS1 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] AASEVASDLEKVGSSNIF;ADQITGLSTVTPGTYSYSE;DTECCNLD;EDDRRKVEEIKAKLFSHE;EEPEEPANLGSE;EKHCIFYPQTL;GPGICWFAPIT;GVSWFVPVEN;HNIFYQQAL;HRPLAGPDRERLR;ISRSGERIKRLKLIVQ;KEAEEPEEPANLGSEKVVMVEEVE;LEEEEEEEEEEKEAEEPE;LQDLRRFEEVAD;LVIQDNFASPDLPLL;PLEEMDCH;QPSELEFVPLRGIPGKS;SDILTQTDREVTLQER;SHREKSNNFYPQELPDK;SKLQKKKRYKSLEKFHK;STVPVPTDQRTE;TYTLDDDTECCNLDENAVV;VLHNSYSQ;YSLGEKHSI 24 6.4 0.97313 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 13.1438 0 0 A0A8P0PCC4 A0A8P0PCC4_CANLF Uncharacterized protein LOC102154218 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EFDSISIDYLP 1 5.8 0.98941 -0.22243 11.1351 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PCD0 A0A8P0PCD0_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934]; membrane [GO:0016020] structural constituent of ribosome [GO:0003735] DRKMTIQQHTLL 1 6.7 0.9486 0.05044 9.00025 0 0 0 0 0 0 0 9.00141 0 0 0 0 0 0 A0A8P0PCD4 A0A8P0PCD4_CANLF Olfactory receptor family 56 subfamily B member 2C OR56B2C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IFLSYALILHSVLKL;LCSNLGVTRLSCDDRTINSIYQLF;LILIIIKQ;LSYALILH;VGMESGIFVCMAI;VISITHSATMTLPLIPVLLNVL 6 25.7 1.0039 -1.6781 0 0 6.08672 6.33321 0 0 0 9.10305 0 0 7.32867 0 0 10.9739 0 A0A8P0PCE2 A0A8P0PCE2_CANLF Germinal center associated signaling and motility like GCSAML Canis lupus familiaris (Dog) (Canis familiaris) regulation of B cell receptor signaling pathway [GO:0050855]; regulation of lymphocyte migration [GO:2000401] ELCYSVISHR;PETEYALIKMTCVTRPSSC 2 30.5 0.99418 -0.56159 0 0 0 0 0 6.85873 0 0 8.95228 0 0 0 0 0 0 A0A8P0PCE9 A0A8P0PCE9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DCSQGYNEENTIFAPGYNFL;PTKEKKKRKKPTKK;TEKEKKQKPTKEKKKRKKPTKKSAR 3 23.8 0.85694 0.14638 0 0 8.75395 0 0 0 0 0 0 0 5.31281 0 0 0 0 A0A8P0PCF6 A0A8P0PCF6_CANLF Neurexin 3 Canis lupus familiaris (Dog) (Canis familiaris) DESDCFCC;EEDESDCFCCPT;GLILPTELWTAMLNYG;LSPKEEDESDCFCC;SPKEEDESDCFCCP 5 5.5 1.0025 -1.3258 0 0 0 0 6.38748 0 0 0 0 4.79831 0 5.50227 0 0 0 A0A8P0PCF8 A0A8P0PCF8_CANLF RNA polymerase II associated protein 1 RPAP1 Canis lupus familiaris (Dog) (Canis familiaris) transcription by RNA polymerase II [GO:0006366] GALVLLPLQRRFSVTLRLAL;GLQNYFLQCL;QEDKEDDEDEDEE 3 3.4 1.0025 -0.84248 6.86839 0 0 0 0 0 0 0 0 0 0 0 0 0 7.54071 A0A8P0PCG6 A0A8P0PCG6_CANLF Collagen type XI alpha 1 chain COL11A1 Canis lupus familiaris (Dog) (Canis familiaris) AAYDYCEHYSPD;AFPEDFSI;DYCEHYSPDCDSSV;GPQGLPGPQGPIGPPGEKMC;IDEYAPEDIMEYDYEY;MLIEGPPGPAGPAG;MLPFRYGGD 7 10.8 0.98443 -0.24412 0 0 0 0 0 0 9.55825 0 0 0 0 0 0 0 0 A0A8P0PCK5 A0A8P0PCK5_CANLF CFAP20 domain containing CFAP20DC Canis lupus familiaris (Dog) (Canis familiaris) LPRENKQILGLIQRFLVLQIYIPL;TESEDDFYGGDSSEEVHCLMSEVV 2 10.6 0.97333 0.041303 0 0 0 0 0 0 0 8.65195 0 0 0 0 0 0 0 A0A8P0PCK7 A0A8P0PCK7_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] AVILRKDMKLA;CALPRYRRFFLPS;DIDDDYYY;DIDDDYYYDDGGGDDEGGVEGD;DISEIQSVCSDVET;DITQLEKEVNVCKQYYQELLKSAER;DLGTITNKCE;ELRDKWDTICGK;FSQAATSASVPT;FYDTPLFEDDDHDSL;GSEKAALQSQLNTIKT;GVEGDGKEPWCQDEAADMD;HEEFLQKLESFSHWISEKSKSVKDI;IDELVKSGHKIMAT;ISILRAAHEGL;IVNVQDTE;KFSLENMAQKFKEFQ;KRGLTPKVSPVQLE;LQTVVSESPVHFENLE;LSGLQACEVTA;MVRVGGGWMALDEFLVKNDPCR;QEMKQIKVAQALCEDLSALV;QESQSLGDKKLDKV;SAETIDQDLNNLKEKW;SLVQEHSALSQQVDE;TIEAYRAAMQTQWSWILQL;TLRPWIDKCQNNLEEIKFC;TQKVEEIDAAILRSQQFD;VDIAGGKLASMSP;VGRDVETLQK;VGRYDDLSKSVNERNEKL;VIADKNNIENLI;YLALLQEMKPPLDNQ;YNLYISEVRNIRL;YRSLENQQNVNVLQ 35 7.1 0.93833 0.060957 0 0 0 0 0 0 0 0 0 3.93847 0 0 0 0 0 A0A8P0PCL3 A0A8P0PCL3_CANLF Leucine rich repeat and coiled-coil centrosomal protein 1 LRRCC1 Canis lupus familiaris (Dog) (Canis familiaris) DLHSLALLTTDRL;HTKNNNPFMSCNRKMKQPFFK;IVEAHHAEIIQL;LDSSLHAINL;LISNRGKLEAQIESL;TLEILIEDDKQKSIQ;VENEDGDSSCG;VWNLRHLDLSSNQISRIEG 8 12.1 1.001 -0.92387 8.79578 7.70425 0 9.09911 5.73844 0 7.39532 0 0 0 0 0 9.59602 0 0 A0A8P0PCQ6 A0A8P0PCQ6_CANLF ATP-binding cassette sub-family B member 6 (EC 7.6.2.5) (ABC-type heme transporter ABCB6) ABCB6 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial outer membrane [GO:0005741]; multivesicular body membrane [GO:0032585] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] IVERGRHEALLSRGGMYADMWQLQ;KEKPEVKDLPGAGPL;LRPQSYALK;MTIVVTEW;VGTAGGAP;VLQLVVLICLGLMGLER 6 9.6 1.0036 -2.3932 0 0 0 0 0 0 10.629 0 0 9.29347 0 0 0 0 4.27381 A0A8P0PCR8 A0A8P0PCR8_CANLF Anti-silencing function 1B histone chaperone ASF1B Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] PVSTSCLGQAGSLEP;QVGPVSTSCLGQAGSLEPG;TDAVGVTVVLITCTYHGQ;VGYYVNNEYPNPELR 4 31.5 0.99118 -0.0027613 0 0 8.64746 4.88947 0 0 0 0 0 7.89657 0 0 9.68405 0 0 A0A8P0PCT5 A0A8P0PCT5_CANLF Multiple EGF like domains 11 MEGF11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APRVSYTPAMRMTSTDYSL;CNESCPAGYYGN;CSCENGGSCSPEDGSCEC;CSQDCPCHHGGQCDHVTGQCHC;EGLHGSGC;FGYGCQQLCECMNN;GPACFHTCSCH;HVSGKCTCRTGF;IVLLLFLIVVLLGLFAWRRRRQ;LLLFLIVVLLGLFAWRRRRQK;NGGSCSPEDGSCECA;PVTGHCCC;RGSPYTDMPSLST;SPATGACECEPGYKGP;TGVYCEELCPPGSH;VLLLFLIVVL;VPCAAGTYGPNCSS;WGPACFHTCSCHNGGSCS;YENGDFCIRCDSDHWGPHCSNRCQC 19 23.4 0.97468 0.035538 0 0 0 0 0 7.28114 0 0 0 0 0 0 0 8.12495 0 A0A8P0PCU2 A0A8P0PCU2_CANLF Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (M-CK) CKM Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] ELSNTSGAHAFST;GYKPTDKHKTDLN;HAFSTPKATNKSNGGPSSCATVTEQ;KGYTLPPHCSRGE 4 11.8 0.99679 -0.11101 0 0 0 0 8.64947 0 0 0 0 0 8.40914 0 9.70195 0 0 A0A8P0PCU7 A0A8P0PCU7_CANLF ATPase family AAA domain containing 5 ATAD5 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ESIPCPKTPAEKKC;FSLETSDGWTSQSSGE;IKQGLSKTSRKKQTTL;INEKPEELDKRN;LEERPLSFCR;MICLAENFR;PSLTNEIKSTA;SPVKISSDDSK;TDGDFTSQ;TPKKSKRKSKKRCEKS;VLALGEFSTLNSN;YLEGIHLNI 12 7.9 0.99708 -3.6339 0 0 8.71119 0 0 0 10.7872 0 7.41193 9.01134 10.4332 9.58425 0 0 0 A0A8P0PCW1 A0A8P0PCW1_CANLF Ceramide kinase like CERKL Canis lupus familiaris (Dog) (Canis familiaris) kinase activity [GO:0016301] CDVQCKEEFI;KKEQNKLKDSTLD;NTRLNNGSMALIIARNTSRP;SILTPVRAQLPLGLI;TESILTPV;VGEVKVRP;VQVKLHPRLINLYGGS 7 15.7 1.0038 -2.0278 0 9.85907 0 0 0 0 0 9.6339 10.6952 0 0 0 7.4266 0 6.68271 A0A8P0PCW7 A0A8P0PCW7_CANLF MLLT3 super elongation complex subunit MLLT3 Canis lupus familiaris (Dog) (Canis familiaris) EAEDNDNDSEME;ECDKIVNLIEETGH;FDFDLCSLDKTTVR;SLSDGSDS 4 34.8 0.93628 0.060945 0 0 0 0 0 0 0 0 0 0 0 8.99141 0 0 0 A0A8P0PCX4 A0A8P0PCX4_CANLF Caspase recruitment domain family member 8 LOC102153616 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] ELVMVEGS;STVDHSTT;VEGSSDDH 3 3.6 1.0035 -2.4467 0 0 0 0 0 0 0 0 0 0 0 0 9.8744 7.83352 0 A0A8P0PCZ8 A0A8P0PCZ8_CANLF Mucolipin 3 MCOLN3 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] SILKMEIQAKLLILT;TYAVYTQRDVY 2 5 0.99264 -0.55168 0 0 0 0 0 0 0 9.58344 0 0 0 0 0 0 0 A0A8P0PCZ9 A0A8P0PCZ9_CANLF Phosphatidylinositol-glycan-specific phospholipase D (EC 3.1.4.50) (Glycosyl-phosphatidylinositol-specific phospholipase D) GPLD1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] glycosylphosphatidylinositol phospholipase D activity [GO:0004621] ALHVYSLGLD;EAHSAGDFGGDVLS;SGALHVYSLGLD;SRLSGALHVYSLGLD 4 3.6 0.72754 0.25189 0 0 0 0 9.41699 9.64852 0 10.9539 10.9969 0 0 10.2967 10.0883 0 0 A0A8P0PD05 A0A8P0PD05_CANLF Sec1 family domain containing 2 SCFD2 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] ALWEALLS;EQVLAKVKRAL;SHAAHLTANHVPAAAAAELEGQ;SPLLQKITVS;WEALLSTKHKE 5 10.2 1.001 -0.95118 0 7.93499 0 0 0 0 12.9942 0 0 0 0 0 0 10.217 0 A0A8P0PD10 A0A8P0PD10_CANLF Rho GTPase activating protein 4 ARHGAP4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AVAACVCL;EKLQEAIERGDKEEREVSWTQYTQR;LGRSKGFSRGSGAPAS;LSHIAEDVGRI;RSKGFSRGSGAPA;TEEVSKTLKATL 6 6.4 1.0029 -0.85385 8.41143 7.54117 11.5216 0 0 0 0 8.59246 0 8.39738 8.27678 0 0 0 0 A0A8P0PD11 A0A8P0PD11_CANLF Tetraspanin 14 TSPAN14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLQNLIDSLQKANQCCGAYGP;GVGGGGKN 2 6.6 1.0032 -1.1044 0 0 0 0 0 0 9.13996 0 0 0 0 0 0 0 2.04677 A0A8P0PD33 A0A8P0PD33_CANLF hydroxyisourate hydrolase (EC 3.5.2.17) Canis lupus familiaris (Dog) (Canis familiaris) purine nucleobase metabolic process [GO:0006144] hydroxyisourate hydrolase activity [GO:0033971] PRLRALQRHLGS;TEAVTWPHPGWIL 2 12.4 0.94677 0.05044 0 0 0 0 0 0 0 5.92519 0 0 0 0 0 0 0 A0A8P0PD36 A0A8P0PD36_CANLF Methyltransferase like 15 METTL15 Canis lupus familiaris (Dog) (Canis familiaris) FFSHNSLHMLLLCYLI;HRPQDRDN 2 16.3 1.0026 -0.76102 0 0 0 0 8.90965 0 0 0 0 0 0 0 0 0 0 A0A8P0PD46 A0A8P0PD46_CANLF Nuclear receptor binding protein 2 NRBP2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EEGVEVVWNEL;GRWQKRREQVNQ;VLFEVHSLKL 3 6.7 1.0025 -0.75667 12.0878 0 0 0 0 8.98328 0 0 0 0 9.50577 0 0 0 0 A0A8P0PD48 A0A8P0PD48_CANLF Cortactin-binding protein 2 CTTNBP2 Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; dendritic spine [GO:0043197] ARPAETPGPNQP;GNGTSECYYFHENC;GPALPPPA;GPAPPPPAGAIAPQGPAPPA;KKPVCTNPLSI;LFISSACLIPVK;LRDELERLRRALEQLRRPGL;SDLPVQQHFRW;TASGWSPSLTPLLMSGG;TYGSDDFE;VLMLVKECK 11 8.1 1.0022 -1.865 0 0 0 7.15532 8.85128 8.64976 0 12.4307 11.9558 10.3432 11.2363 0 0 0 13.0022 A0A8P0PD65 A0A8P0PD65_CANLF phosphatidate phosphatase (EC 3.1.3.4) LPIN1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] DDNTNTSEDEDMFPI;ESPSPIMTYPQS;GSLVKKRRKRRRK;IPMYLATSPIL;LLAMQAFQK;LVKKRRKRRRK;PKPLSASVAPTASKTDSPS;SLVKKRRKRRRK;TMQKNNLE;VGVSLNRIFTVNP;WIRNVWPSNINTQT 11 12 1.0018 -1.8124 9.83485 0 12.3488 0 10.4222 8.61062 0 8.48325 14.118 0 0 5.54421 10.7166 9.25515 4.97485 A0A8P0PD71 A0A8P0PD71_CANLF "Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (Telokin)" MYLK Canis lupus familiaris (Dog) (Canis familiaris) muscle structure development [GO:0061061] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; protein kinase activity [GO:0004672] DTGTYTCE;EPQVTWHRNG;GVAELHIQDALPEDDGIYT;IEKALPEDRGFYK;IQEVFPEDTGTYTCEAWNS;ISNAKPAE;LDLKPENIMCVNKTG;LPGEEATT;LVKRLAVMEVAP;RAIGRLSSMAMI;SGLSPFMGDNDNETLA;VIHAVREEDQGKYT;VINYEPIGY;VLKDCAVIEGQDFVLQCSVQG;WTLLVKRL 15 8.9 0.98824 -0.22507 0 0 0 0 0 8.55842 0 0 0 0 0 0 0 0 0 A0A8P0PD72 A0A8P0PD72_CANLF DIS3-like exonuclease 2 (EC 3.1.13.-) DIS3L2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; polyuridylation-dependent mRNA catabolic process [GO:1990074] P-body [GO:0000932] 3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; RNA binding [GO:0003723] GVLQDQAQFRHYALNVPLYTHFTS;IVDWKEDS;LDDALSCKPLADGNFEVG;LFSPSDHRV 4 6.8 1.0039 -0.80851 8.30793 0 8.26374 0 8.0649 0 0 0 10.3648 0 0 0 0 0 0 A0A8P0PD90 A0A8P0PD90_CANLF MIER family member 2 MIER2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RHVYENEDQL 1 1.9 0.99031 -0.26756 0 0 0 0 0 0 0 0 10.5992 0 0 0 0 0 0 A0A8P0PD94 A0A8P0PD94_CANLF NIMA related kinase 10 NEK10 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EKSTDKKQGITTRD;ELTIIKEQLYHPN;TSVEIRIWGGIKQLLHILR 3 6.5 0.99746 -0.10765 0 0 0 0 0 0 10.3246 6.74147 0 9.775 0 0 0 9.49097 0 A0A8P0PD97 A0A8P0PD97_CANLF Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) DNM2 QTRT1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; endocytosis [GO:0006897]; innate immune response [GO:0045087]; tRNA-guanine transglycosylation [GO:0101030] microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479] RSKLQSQLLSLEKEVE;SHSPTPQR;TPVFMPVGTQATM 3 3.3 0.9876 -0.40245 0 0 0 0 6.74376 0 0 0 0 0 0 0 0 0 6.4472 A0A8P0PDC7 A0A8P0PDC7_CANLF Pyruvate dehydrogenase E1 component subunit beta (EC 1.2.4.1) Canis lupus familiaris (Dog) (Canis familiaris) acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006] pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739] LQVTVREALNQGTD 1 6.2 0.94492 0.061155 0 0 0 0 0 0 0 0 0 0 0 0 9.50156 0 0 A0A8P0PDC8 A0A8P0PDC8_CANLF Fatty acid hydroxylase domain-containing protein LOC102153215 Canis lupus familiaris (Dog) (Canis familiaris) sterol biosynthetic process [GO:0016126] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] LLHHKRIYKYIRKVHHEFQA;MLLCDHVI;PVEYVDSL;VIEDTWHYFL 4 15.7 1.0021 -1.2472 0 0 0 0 0 0 0 0 9.74086 8.14858 0 0 0 11.9415 0 A0A8P0PDD3 A0A8P0PDD3_CANLF HMG box domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EESRQRQSRMEKG;GVDSMAKEGTSDSN 2 7.8 0.90433 0.12081 4.45727 9.19623 0 0 0 0 0 0 9.71516 0 0 0 0 0 0 A0A8P0PDE2 A0A8P0PDE2_CANLF LRRCT domain-containing protein RTN4R Canis lupus familiaris (Dog) (Canis familiaris) AEGGGGQQ;NRIVHVPAAGFRA;PPGNGSGP;SPPGNGSG 4 5.7 1.0031 -2.4127 11.5018 0 14.4217 10.8748 8.292 0 0 10.8349 0 0 13.1813 9.4379 12.9462 12.8174 12.8541 A0A8P0PDE8 A0A8P0PDE8_CANLF K Homology domain-containing protein FUBP1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] RNA binding [GO:0003723] APAGQVDYTKA;GGGGGGGG;HGDGPGNAVQEIMIPASK;PGGPGPGG;PMGPYNPAPYNP 5 9.7 1.003 -1.5883 15.931 0 0 0 0 7.68194 0 5.47168 0 0 16.4319 0 0 0 0 A0A8P0PDF0 A0A8P0PDF0_CANLF Peripherin-2 (Retinal degeneration slow protein) PRPH2 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] membrane [GO:0016020] ESHFVPNSL 1 2.7 1.0035 -0.80421 0 12.1532 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PDG3 A0A8P0PDG3_CANLF Synaptosomal-associated protein Canis lupus familiaris (Dog) (Canis familiaris) neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202] IDRITEKADTNN 1 7.8 0.9489 0.05044 7.41456 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PDH0 A0A8P0PDH0_CANLF Non-SMC condensin I complex subunit G NCAPG Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] condensin complex [GO:0000796] GGRKRLLAILQEILTLPTTPISL;MAEIKVKLIETKEAL 2 3.8 0.9379 0.10015 0 0 0 0 0 0 0 0 5.0321 0 5.44417 0 0 6.47646 0 A0A8P0PDH1 A0A8P0PDH1_CANLF Olfactory receptor OR7G3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NPKLCRLLVLLSFLISV;TEFLLLGLSEDPELQ 2 10.3 0.9929 -0.06954 0 0 0 4.88889 0 0 0 0 0 0 0 8.67027 0 0 0 A0A8P0PDI7 A0A8P0PDI7_CANLF MPN domain containing MPND Canis lupus familiaris (Dog) (Canis familiaris) metallopeptidase activity [GO:0008237] DIDSQMDYQLRLQG;GGCGGPGGALTRRAVTLRVLLKDA;GPLEPAHTEAVT;GPQFPRSP 4 9.5 1.0038 -1.1044 0 0 0 0 0 0 6.6315 0 0 0 0 0 0 5.71425 0 A0A8P0PDM0 A0A8P0PDM0_CANLF ELKS/RAB6-interacting/CAST family member 2 ERC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; presynapse [GO:0098793] EEIESFRKENKDLKEKVNALQ;IELTEENFRRLQ;MADNYDEDHHHYHHH;TVIEMKEAPSFNFDP 4 6.4 0.98533 -0.43666 7.79507 0 2.8863 0 0 0 6.95675 0 0 0 0 0 0 0 0 A0A8P0PDM9 A0A8P0PDM9_CANLF Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) TMEM175 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267]; proton channel activity [GO:0015252] GVPALCPAHLLCPQCA;SVRVSCAIIFFASIFQ;VGLLWFAHHSLFL 3 8.3 0.96361 0.049233 0 0 0 0 0 0 0 0 8.44865 0 0 0 0 0 0 A0A8P0PDT5 A0A8P0PDT5_CANLF "Zinc finger protein, FOG family member 2" ZFPM2 Canis lupus familiaris (Dog) (Canis familiaris) anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629] GAAAAAEMS;GAAAAAEMSRRKQSKPRQIKRPL;GGGGGGGA;GGGGGGGG;SEENEDSAPQISSL;SFSYTKIKSEPSSPRL;SSNGCAGP 7 5 1.0032 -1.6968 0 9.99958 0 0 4.43456 0 0 0 0 5.62764 0 0 0 4.57791 7.54805 A0A8P0PDV9 A0A8P0PDV9_CANLF Matrix metallopeptidase 27 MMP27 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] DINGIQSIYGSLPTA;GIADIMIAFRTRGF;KDDNFWMIRGYAVL;RHVWRIYYDITDVEFELISSFWPSL;YRIVNYTPDMARVDVDKAIQ 5 18.8 0.9968 -0.11148 9.55534 7.81756 0 0 0 0 0 0 0 11.0946 0 0 0 5.84584 7.2926 A0A8P0PDW9 A0A8P0PDW9_CANLF HECT-type E3 ubiquitin transferase (EC 2.3.2.26) NEDD4L Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-protein transferase activity [GO:0004842] FNRLDLPPYE;GAEQRRSAGAQ;GGGGGGPG;PGGGGGGG;PGWEMRIAPNGRPFFIDHNT;RILRVKVVSGIDLAKKD;SEIMVTNENKREYIDLVIQWRF 7 7.9 0.86166 0.18229 0 0 0 7.54063 6.0507 0 0 6.82094 9.69323 0 0 0 0 0 0 A0A8P0PDX5 A0A8P0PDX5_CANLF EGF-like domain-containing protein LOC475605 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] AAASRNLTRREE;CDEGKCIPESL;CDGHADCPDGSDEM;DCGDSSDEDACASCPDGMV;ECPDGSDEQCEE;EDCADGSDEGGKCSSLLSACSQ;GVNDCGDSSDEDAC;GVNDCGDSSDEDACAS;GVNDCGDSSDEDACASCPD;GVNDCGDSSDEDACASCPDG;GVNDCGDSSDEDACASCPDGM;IVFPTKKSLYWVNRGKK;KDPQKAKHLPCS;LLLLLLLL;LLLLLLLLP;LLLLLLLP;LSQQGSNSCSKDNGGCSHMCLP;MFLLPSGTCSEL;SGGQPCSQTC;TGIEPILLVAVQS 20 8.9 0.98527 -0.44678 0 0 7.75241 0 0 7.51009 11.2329 4.57386 7.53916 4.97865 0 9.83725 8.35209 0 12.8486 A0A8P0PDY2 A0A8P0PDY2_CANLF "SPHK1 interactor, AKAP domain containing" SPHKAP Canis lupus familiaris (Dog) (Canis familiaris) CPWLPDICLV;GASGAPMGV;LDYYAGKN;LVSTHPLGGSEPLQT;RDIERESRDSASSRRS;VINDLGDEVHLK 6 4 1.0031 -2.3355 0 0 9.89544 0 0 0 0 0 0 10.7602 10.7568 7.04319 11.0572 12.9249 0 A0A8P0PDZ3 A0A8P0PDZ3_CANLF Transport and golgi organization 6 homolog TANGO6 Canis lupus familiaris (Dog) (Canis familiaris) DEIMRNFLFP;GDLLSHCQEC;HVIVLLLRGL;SERLMRPSGVQ 4 4.1 0.99122 -0.1336 0 8.56913 10.5421 0 0 0 0 0 0 0 9.87918 0 0 0 0 A0A8P0PDZ6 A0A8P0PDZ6_CANLF SH3 domain and tetratricopeptide repeats 1 SH3TC1 Canis lupus familiaris (Dog) (Canis familiaris) EAECEQPEPAMP;EQCKSCQDCPEEPASWGL;LARLHSRHGQQ;LLLADIYSRQ;MCMCVTCECCVCVSCVPC;PSLQQTVRRRLRLL;QVVPKASALLLGTPSH;VHARMCMCVTCECCVCVSCVPC;VLEQCKSCQDCPEEPASWGLCSASS 9 7.5 1.0009 -0.92615 0 0 4.12176 7.45943 5.80841 0 7.62205 0 7.17243 8.41409 0 0 0 0 0 A0A8P0PE06 A0A8P0PE06_CANLF V-type proton ATPase subunit C ATP6V1C1 Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; proton-transporting V-type ATPase, V1 domain [GO:0033180]; synaptic vesicle membrane [GO:0030672]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" GLPVNFQAMLLQPN;KQYETLAEMVVPRSSNV;YETLAEMVVP 3 8.2 0.98764 -0.48643 0 9.37025 0 0 0 0 0 10.2692 0 8.22901 0 0 0 0 0 A0A8P0PE21 A0A8P0PE21_CANLF Protein kinase AMP-activated non-catalytic subunit gamma 2 PRKAG2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] MLEKFELEEEEDSESG 1 3.5 0.95864 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 7.07371 0 0 A0A8P0PE25 A0A8P0PE25_CANLF Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B PPP2R2B Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; membrane [GO:0016020]; protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] SEIISSISDVK;VGGGEAFSCSQFERA 2 5.7 0.98181 -0.2487 0 0 0 9.00211 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PE31 A0A8P0PE31_CANLF Erythrocyte membrane protein band 4.1 like 3 EPB41L3 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] actin binding [GO:0003779]; structural molecule activity [GO:0005198] AEPMKAFPPTAD;EKDYFGLTYRDA;LIKRIKGENVYVKHS;QKSSSSKLSRSPL;STRLTRMEPAEG;TETKTITYE;TETSHLAPSPQPLSTEK 7 7.6 0.95215 0.053874 0 0 0 0 0 5.63273 0 0 0 0 0 0 0 0 0 A0A8P0PE34 A0A8P0PE34_CANLF Keratin 14 KRT14 KRT42 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] ELTLSRAD;ELTLSRADLEMQIET;GFGSGFSS;GVGSCGTMSVTSSRFS;LGGGYGGG;TVQNLEIE;VEMDAAPGVDLSRILN 7 15.8 0.99764 -3.3675 3.35135 0 8.42463 7.64068 8.85456 0 0 0 13.8832 0 8.5877 0 0 8.32103 0 A0A8P0PE76 A0A8P0PE76_CANLF Adiponectin receptor 1 ADIPOR1 KLHL12 Canis lupus familiaris (Dog) (Canis familiaris) DLMQAAEVFSQK;TQEWSFLPSI 2 3.9 0.93944 0.10003 0 0 0 0 8.84925 0 0 0 0 0 0 0 6.95501 0 0 A0A8P0PEA0 A0A8P0PEA0_CANLF cholestenol Delta-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) EBP Canis lupus familiaris (Dog) (Canis familiaris) sterol biosynthetic process [GO:0016126] endoplasmic reticulum membrane [GO:0005789] cholestenol delta-isomerase activity [GO:0047750] VGHPLYFWFY;VGHPLYFWFYFVF 2 5.7 0.99116 -0.19573 6.8627 0 0 0 0 0 9.00248 0 0 0 0 0 0 0 0 A0A8P0PEB1 A0A8P0PEB1_CANLF Reverse transcriptase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TVNPQVWDTSKPTG 1 4.1 0.9879 -0.22574 0 0 0 0 0 9.22713 0 0 0 0 0 0 0 0 0 A0A8P0PEB8 A0A8P0PEB8_CANLF Eukaryotic translation initiation factor 4E family member 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] REREREERDREGG 1 5.6 0.93918 0.059722 0 0 0 0 0 0 0 8.14517 0 0 0 0 0 0 0 A0A8P0PEC6 A0A8P0PEC6_CANLF DEF6 guanine nucleotide exchange factor DEF6 Canis lupus familiaris (Dog) (Canis familiaris) LQEAQRQAERLLQ;RLQQLQEEKERKLQELELLQEAQRQ;VGLGELEELL;VLPDREGKRCMFCVKTAS 4 10 0.98758 -0.49765 9.37363 0 0 5.96968 0 0 0 8.00703 0 0 0 0 0 0 0 A0A8P0PED1 A0A8P0PED1_CANLF t-SNARE domain containing 1 TSNARE1 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] membrane [GO:0016020] GVAVEGRGTPEPASPPAAG;INSSVSSLEQSLRSLGTPS;LTVGGSGG;PIGDRVPCSPTG 4 7.1 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 13.1969 0 0 0 0 0 A0A8P0PED4 A0A8P0PED4_CANLF Minichromosome maintenance domain containing 2 MCMDC2 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508] chromosome [GO:0005694] ATP binding [GO:0005524]; DNA binding [GO:0003677] AALLFETSLTL;KYLVSLAEAHARLSLRNKVL;RVHVPGAT;VEFSLEAE 4 7.6 1.0017 -1.2622 6.63147 0 0 6.46509 7.14354 5.43633 0 0 6.87135 0 0 0 7.2902 9.01645 0 A0A8P0PED5 A0A8P0PED5_CANLF DNA polymerase alpha subunit B POLA2 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634] DNA binding [GO:0003677] PVDLSELKEYSLFPGQ;SLKVLGCPESLTGSYKSMFQKLPDI;SYYPLYPPQEDMAIDY;VLGCPESLTGSYKSMFQKLPDI 4 9.6 0.98995 0.014337 0 0 0 0 0 0 0 10.4612 0 0 0 0 4.87926 6.61064 9.37332 A0A8P0PEF9 A0A8P0PEF9_CANLF Olfactory receptor OR10AA5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FGSAFVVYVGLPGSQAEGTDKCIAL 1 8 0.97903 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 9.96824 0 0 A0A8P0PEI6 A0A8P0PEI6_CANLF Amine oxidase (EC 1.4.3.-) Canis lupus familiaris (Dog) (Canis familiaris) amine metabolic process [GO:0009308] copper ion binding [GO:0005507]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038] DVTVERHGGPL;SVQGSRVSS 2 3.1 0.81524 0.20454 0 0 0 0 0 0 0 0 0 0 0 13.6267 0 0 0 A0A8P0PEI9 A0A8P0PEI9_CANLF Death associated protein kinase 2 DAPK2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LAPMFLAGLTLGF 1 3.2 0.98486 -0.24538 0 0 0 0 0 0 0 0 0 12.0743 0 0 0 0 0 A0A8P0PEJ2 A0A8P0PEJ2_CANLF Zinc finger protein 805 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] GEKPYECMECGKSFC;RDRPGFIRHYI;SYLKRHQRIHTGEKP;YECFECGKVFKHRSYL 4 10 0.9919 -0.20678 0 8.98128 0 0 0 0 0 0 7.4945 0 0 9.1938 9.37998 0 9.80842 A0A8P0PEL1 A0A8P0PEL1_CANLF Catenin alpha-2 (Alpha N-catenin) CTNNA2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell differentiation [GO:0030154] axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634] actin filament binding [GO:0051015]; cadherin binding [GO:0045296] ESVLDSATSLIQ 1 1.9 0.9909 -0.22162 0 0 0 0 0 0 0 0 0 0 0 0 13.0022 0 0 A0A8P0PEL2 A0A8P0PEL2_CANLF Phosphatidylethanolamine binding protein 4 PEBP4 Canis lupus familiaris (Dog) (Canis familiaris) DEGDMCLYEALSD;SPAPTEEGP;SPPAQTGFH 3 10.3 1.003 -1.3325 0 0 0 0 0 2.37521 0 8.68849 0 0 0 0 8.80555 0 7.8189 A0A8P0PEL6 A0A8P0PEL6_CANLF RIMS binding protein 2 RIMBP2 Canis lupus familiaris (Dog) (Canis familiaris) DEAWEQGRAPA;EAWEQGRAPAPVHGHMLEPPSLQ;EVAEEGEH;FLEPPEHP;ILLGGISLVVLINSER;KGVTVRTLSA;LPTNSNYSHVIFLNEEE;RCRFESDMDNER;SPNIDVEAELTF;TAGKYLYVYGDMDEDGFY;VPSIDEYSERDHLSPDFYEESETD 11 10.5 0.95617 0.049233 0 0 9.41787 0 0 0 0 0 8.14241 0 0 0 0 0 0 A0A8P0PEM3 A0A8P0PEM3_CANLF Bifunctional purine biosynthesis protein ATIC (EC 2.1.2.3) (EC 3.5.4.10) (AICAR transformylase/inosine monophosphate cyclohydrolase) Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643] NCWWLRHHLQ;WVDKLSEVSISSDAFFP 2 5.3 0.99978 -0.61146 0 0 0 0 0 0 0 4.55508 0 0 0 0 0 0 0 A0A8P0PEM5 A0A8P0PEM5_CANLF MPN domain containing MPND Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] DIDSQMDYQLRLQG;GGCGGPGGALTRRAVTLRVLLKDA;GPLEPAHTEAVT;LVEFYKGAP;VLEQVYSLLKQ 5 15.6 1.0022 -0.68721 0 0 0 0 9.62845 0 0 6.45878 0 10.9711 0 9.03315 0 0 0 A0A8P0PEM7 A0A8P0PEM7_CANLF Spermatosis associated 6 SPATA6 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] myosin light chain binding [GO:0032027] HLDDGEYWSNR;HSDWCSPSN 2 4.3 1.0028 -0.76872 0 0 6.56999 0 0 0 0 4.53076 0 0 7.71973 0 0 0 0 A0A8P0PEM8 A0A8P0PEM8_CANLF Transmembrane protein 266 TMEM266 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] voltage-gated channel activity [GO:0022832] ALPPRLGASPLVASGAGCPA;DLLSSPLEGPCP;GVPEPAACVVTTAAID;LSSPLEGPCP 4 7.2 0.9912 -0.20617 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.92837 A0A8P0PEN5 A0A8P0PEN5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SRPK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] GPKAGAKP;IELLGKVPRKL;IRKLGWGHFSTVWLSWD;KKLKKKQK;KKLKKKQKRQAELL;KNKKKKLKKKQK;NKKKKLKKKQKRQAELLEK;QDFFNRRDHIAL;VEGGAPEI;VLQGLDYLHTKCRIIHTDI 10 10.5 1.0024 -0.95899 0 7.91397 0 0 12.377 6.07007 0 8.10575 0 0 8.45302 9.91256 0 7.75916 0 A0A8P0PEP0 A0A8P0PEP0_CANLF Pecanex-like protein PCNX3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AITEGVEEDEGCCCCEPGH;CCCCEPGH;DEGCCCCEPG;DGAGGDVL;EDEGCCCCE;EEDEGCCCCE;ELQEEGAVGGAEEPGKRDR;FVLASDYLNALVHLIE;GVEEDEGCCCCE;LGYLLLLKGFFTDIWV;LLKGFFTDIWVFQ;PGPGWGPRPSLSGSGDGRP;RRGAGGYQP;SLPSFCAVHLEWIQ;TDIWVFQFCL;VEAITEGVEEDEGCCCCEPG;VEEDEGCCCCEPG;VISHEGDPAWRS 18 6.9 0.99687 -6.2226 12.9785 0 8.13299 5.92631 4.13348 8.35645 0 0 5.45608 0 7.74631 8.01112 8.59496 11.3856 0 A0A8P0PEQ4 A0A8P0PEQ4_CANLF UTP6 small subunit processome component UTP6 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" nucleolus [GO:0005730] snoRNA binding [GO:0030515] DDPLTWDYVARRELE;EINLLELIQRRRTRIGY;YEEAIDLLLHHDFLKEAL 3 9.3 0.85362 0.1593 0 0 0 0 4.33964 0 8.03205 0 0 0 0 0 0 0 10.767 A0A8P0PEU1 A0A8P0PEU1_CANLF SR-related CTD associated factor 8 SCAF8 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ATSQRKGDNVPQVN;DIESEPVVESTE;HLRQQLLEQQ 3 3 1.003 -0.85164 0 3.23174 0 0 0 0 0 10.3932 0 0 10.3409 0 0 0 0 A0A8P0PEU3 A0A8P0PEU3_CANLF WD repeat domain phosphoinositide-interacting protein 2 WIPI2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site membrane [GO:0034045] lipid binding [GO:0008289] LVAIVSLKAPRKLK;VGASDGYLYMYNLDPQE;VIRVFSIPE;YFGKVLMASTSYLPSQVTEMF;YKEPPRELDDVKEEQGGPPFERS 5 20 0.99011 -0.27351 0 0 0 0 0 9.69471 0 0 0 0 0 0 0 0 0 A0A8P0PEU6 A0A8P0PEU6_CANLF Ovo like zinc finger 2 OVOL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] EDCRSDGGSSSGGGS;PGAQVQGG;TGIRPYKCD;VQQQYAYKQR 4 10.9 1.0048 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 9.62547 0 A0A8P0PEW0 A0A8P0PEW0_CANLF EF-hand domain-containing protein LOC490131 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743] calcium ion binding [GO:0005509] EQFASASLAGATAQSF;MNLNNKTAKQQQQQQQQQQQQQQR 2 7.7 0.93434 0.090535 0 10.2678 0 0 0 0 0 9.3546 0 0 0 0 0 0 0 A0A8P0PEW5 A0A8P0PEW5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) YYCVTEHGSGSSFTY 1 14.3 0.94816 0.053889 0 0 0 0 5.76765 0 0 0 0 0 0 0 0 0 0 A0A8P0PEW7 A0A8P0PEW7_CANLF Nephrocystin 4 NPHP4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of canonical Wnt signaling pathway [GO:0090090] cytoskeleton [GO:0005856]; non-motile cilium [GO:0097730] ITTMHTIH;KVQQVESG;SRKVGSSSKTSSGNQ;TIEVDNPELSIIQD;VGHVCEQRVRDSS 5 4.2 1.0018 -1.289 0 10.6353 0 0 0 8.38046 0 0 0 0 0 0 0 10.6381 0 A0A8P0PEX0 A0A8P0PEX0_CANLF Secretory carrier-associated membrane protein (Secretory carrier membrane protein) SCAMP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] membrane [GO:0016020] ASAVISLVMFKKVH 1 4.5 0.98337 -0.25616 0 0 0 0 0 0 12.9079 0 0 0 0 0 0 0 0 A0A8P0PEX5 A0A8P0PEX5_CANLF Zinc finger protein 335 ZNF335 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] ATIIYQQGAEEST;EAFPGRAEMESH;EAMMEVVVVQQFKCK;EVVVVQQFKCK;LILQGPDDGAPMASPMSSST;LSSFPCPVCGRVYPMQKRLTQ;QEITTADGQTVQ;RKKRPDPTPKLS;VSPGQQLVTQAQL;VVKSEDMEAELACPG 10 9.8 1.0021 -0.68595 10.6198 8.96246 8.56708 9.74917 0 0 9.79194 0 0 0 0 7.81487 7.74086 0 10.0196 A0A8P0PEY5 A0A8P0PEY5_CANLF IQ motif containing GTPase activating protein 3 IQGAP3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane bounded cell projection [GO:0120025] ERFAMDEYSDMVAVAK;LEQLSSDREQKA;VAKVLRTTLA;VGNLLYYRFLNP;YHAGQGGA 5 3.7 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.4634 0 0 0 A0A8P0PEY7 A0A8P0PEY7_CANLF CD2 associated protein CD2AP Canis lupus familiaris (Dog) (Canis familiaris) IIHLISKKPKKPPPPAKG;QTKNIKKKTKKRQCKVLFEYLPQNE;SFRHFFFFFLVDYIV 3 9.3 0.97336 0.048313 0 0 0 0 0 5.71817 0 0 0 4.95759 0 4.66135 0 0 0 A0A8P0PF01 A0A8P0PF01_CANLF Thrombopoietin THPO Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283] extracellular region [GO:0005576] cytokine activity [GO:0005125]; hormone activity [GO:0005179] SPLLIAAH;SSAHLCPTVQEVPE 2 5.4 0.9858 -0.43463 0 0 4.8847 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PF02 A0A8P0PF02_CANLF FKBP prolyl isomerase like FKBPL Canis lupus familiaris (Dog) (Canis familiaris) TEIRQQPQDCPTEILEL;TQGRDSWELEA 2 8 0.98389 -0.24308 0 0 0 0 0 0 0 0 0 0 9.18621 0 9.5835 0 0 A0A8P0PF19 A0A8P0PF19_CANLF MTSS I-BAR domain containing 1 MTSS1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane organization [GO:0007009] actin binding [GO:0003779] GDIQPQLDSALQDVNDK;GLFQTIISDMKGSYP;GVKLKKTT;PPSSPSTT;RQFSSALIDCLINPLQ 5 9.3 1.0019 -1.2936 0 0 10.038 0 0 0 0 6.03903 0 0 10.0467 0 8.23621 10.0566 11.4335 A0A8P0PF64 A0A8P0PF64_CANLF Nucleolar GTP-binding protein 2 GNL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] GTP binding [GO:0005525] EQQEEEEDQPGDSEEESC;LEVATDTSQ;NAESPAAS;SGEEEEQQEEEEDQP;SLQKFQEEMGAVMKDPYKVVMKQSK;VGKMVLNDWQRG;VGKMVLNDWQRGRIPFFVKPPNAE;VIDSSDVVVQVL 8 14 1.0021 -1.3962 0 0 0 5.01957 7.46622 8.76832 0 11.5755 8.86935 7.90388 0 5.95552 11.035 0 0 A0A8P0PF82 A0A8P0PF82_CANLF AE binding protein 1 AEBP1 DBNL Canis lupus familiaris (Dog) (Canis familiaris) cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; ruffle [GO:0001726] actin binding [GO:0003779] EVIDEGWWRGYGPDGHFGMFPANYV;KSPTDWWAPGGLGGPG 2 9.3 0.94556 0.084771 0 6.27839 0 0 0 0 0 5.62793 0 0 0 0 0 0 0 A0A8P0PF87 A0A8P0PF87_CANLF DnaJ heat shock protein family (Hsp40) member C7 DNAJC7 Canis lupus familiaris (Dog) (Canis familiaris) NKAFKEGNYKLAYELYTEALGIDPN 1 7.2 0.97952 0.035538 0 0 0 0 0 0 0 9.23647 0 0 0 0 0 0 0 A0A8P0PF95 A0A8P0PF95_CANLF Synaptotagmin 11 SYT11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDVMLGSLTFSVDYNF;HRVKTRVLRKTLDP;SNKKKIIKVRRD 3 9.8 1.0026 -0.77152 0 0 0 0 0 0 0 0 0 0 0 0 0 8.45557 0 A0A8P0PF96 A0A8P0PF96_CANLF Neuropeptide FF receptor 2 NPFFR2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of MAPK cascade [GO:0043408] plasma membrane [GO:0005886] neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628] AFIIIVIIWVLTIVIMSPSAI;LSDYADLSLNELRVINIYI;PFKPKLTIKAAFIIIVIIWVLT;SWLPLWTLMML;VAAIIISYFLIFFL 5 17.9 0.7486 0.24 0 6.69905 0 0 8.29352 0 8.15137 0 8.73349 0 0 0 6.73944 0 8.55229 A0A8P0PF97 A0A8P0PF97_CANLF G3BP stress granule assembly factor 1 G3BP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229] RNA binding [GO:0003723] GEQGDVEPRRIVRHPDSHQLFIGN;GVGRGIAP 2 6.9 0.98981 -0.26592 0 0 0 0 0 0 16.4038 0 16.2947 0 0 0 0 0 0 A0A8P0PFB3 A0A8P0PFB3_CANLF Myosin IG MYO1G Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] AILHLGNV;DLVVCLHRSRP;EACSAAGT;EEYEREGIAWQSVDYFN;ERNFHAFYQVL;LVSVEPKPEQPEPE;RLIPIIVLLLQK;SMNPYQELPL;VEPKPEQPEPEFR;VRKVNRFHK;YARDACAK 11 10.9 0.98869 -0.22689 0 0 10.1548 0 0 0 0 0 0 0 9.66514 0 0 0 0 A0A8P0PFB6 A0A8P0PFB6_CANLF Nascent polypeptide associated complex subunit alpha NACA Canis lupus familiaris (Dog) (Canis familiaris) nascent polypeptide-associated complex [GO:0005854] AAKASPNLGDVS;AVSNIQENTQTPTVQ;GTTLPLGVAHSPTDTPAFL;HPPSGATTPQAVPP;ISNKDSASHAS;PATSSPKKA;PSGVVSTPLEAPFPQ;PSSPKDSQ;QEESEEEEVDETGV;VLKNNKGSGTESDS 10 6.5 1.0023 -1.301 0 8.3612 0 0 9.44719 3.5493 9.45183 0 10.8024 9.63887 0 0 0 0 0 A0A8P0PFC2 A0A8P0PFC2_CANLF Acyl-CoA thioesterase 6 ACOT6 Canis lupus familiaris (Dog) (Canis familiaris) AQVDAWQRIQTFFHKH;DERGALFRAHARYRA;DLQLEYFEEAVN;DLYGSGGGLCEYRASLLA;IVGMDDNNWKSSFY;NFEDLPKEIDSVDL;VAFSGILD;VKGPNVGL 8 17.6 1.0035 -1.0695 0 6.3073 0 0 8.93086 8.09919 0 0 10.0235 0 0 9.21298 7.80523 0 0 A0A8P0PFE0 A0A8P0PFE0_CANLF Pleiotrophin (PTN) PTN Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083]; heparin binding [GO:0008201] WPSPSPAG 1 2.8 0.99012 -0.26349 0 0 0 0 0 0 0 0 10.1286 0 0 0 0 0 0 A0A8P0PFF7 A0A8P0PFF7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KAGSGPGA;LVCNPYPSGRGGGMWPRPGG;PALAATVF;TVFFCLGQTTRPRSWCLRLVCNP 4 46.8 0.9473 0.050235 0 0 0 0 0 6.16465 0 0 0 0 0 0 0 0 0 A0A8P0PFF9 A0A8P0PFF9_CANLF RNA binding motif protein 5 RBM5 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] spliceosomal complex [GO:0005681] metal ion binding [GO:0046872]; RNA binding [GO:0003723] PTTGLYYDPNSQYYYNSLTQQY;SVQSVDYYCDTIILRN;VRNGDEENPL 3 6.1 0.99278 -0.16055 0 0 0 0 0 0 0 0 0 0 0 9.05134 11.0684 7.38301 0 A0A8P0PFG5 A0A8P0PFG5_CANLF Tubulin epsilon and delta complex 1 TEDC1 Canis lupus familiaris (Dog) (Canis familiaris) CHSDRSLGHLSVAETEMLRDPE;RPGRRPRH 2 4.9 1.004 -1.1044 9.49595 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PFH7 A0A8P0PFH7_CANLF gluconokinase (EC 2.7.1.12) (Gluconate kinase) IDNK Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] ATP binding [GO:0005524]; kinase activity [GO:0016301] FDTLEPPSAP;IITSSNPAFWK 2 10.1 0.99585 -0.5703 0 0 0 0 3.81414 0 0 0 0 0 0 0 10.3835 0 0 A0A8P0PFI4 A0A8P0PFI4_CANLF ATP synthase lipid-binding protein (ATPase protein 9) (ATPase subunit c) ATP5MC3 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial membrane [GO:0031966]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" lipid binding [GO:0008289]; proton transmembrane transporter activity [GO:0015078] PARRPPPPSGCRAAD;RRRRRRRREG 2 8.6 0.93681 0.066313 0 8.09032 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PFI6 A0A8P0PFI6_CANLF Ras homolog family member A RHOA Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] GTP binding [GO:0005525]; GTPase activity [GO:0003924] YVADIEVDGKQVEL 1 14.7 0.98492 -0.25497 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1055 0 A0A8P0PFJ2 A0A8P0PFJ2_CANLF Calcium and integrin-binding protein 1 (Calmyrin) CIB1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell division [GO:0051301]; spermatogenesis [GO:0007283] apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perikaryon [GO:0043204]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383] calcium ion binding [GO:0005509] ELLPQEHRSVEE;IFDFDDDGTL;SLLEEGAIVLKERET 3 14.5 0.99683 -0.57633 0 0 0 10.0338 0 0 0 10.0642 0 0 0 0 9.86428 0 0 A0A8P0PFJ3 A0A8P0PFJ3_CANLF "3-hydroxyanthranilate 3,4-dioxygenase" Canis lupus familiaris (Dog) (Canis familiaris) pyridine nucleotide biosynthetic process [GO:0019363] "3-hydroxyanthranilate 3,4-dioxygenase activity [GO:0000334]; iron ion binding [GO:0005506]" ENRASFLP;RKDYHIEE 2 22.2 1.002 -1.3703 0 0 0 0 0 0 0 0 0 0 0 9.88455 0 0 10.3453 A0A8P0PFJ5 A0A8P0PFJ5_CANLF Olfactory receptor family 12 subfamily J member 1 OR12J1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAIASSPRLHTPM 1 4.2 0.9885 -0.26438 0 0 0 0 0 9.3581 0 0 0 0 0 0 0 0 0 A0A8P0PFJ7 A0A8P0PFJ7_CANLF Zinc finger protein 451 ZNF451 Canis lupus familiaris (Dog) (Canis familiaris) TAVWHAYPVL;YEIDLSDFREFVNNNIKSN 2 3.7 0.98742 -0.49789 0 0 0 0 0 0 0 9.25008 0 0 0 0 11.329 0 0 A0A8P0PFJ8 A0A8P0PFJ8_CANLF Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) GABRA2 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] DTYNMRLLLLVVL;TVILSQVSFWLNRESVP;WKDERLKF 3 10.4 0.93778 0.059741 0 0 0 0 0 0 0 6.34346 0 0 0 0 0 0 0 A0A8P0PFK8 A0A8P0PFK8_CANLF Coiled-coil glutamate rich protein 1 CCER1 Canis lupus familiaris (Dog) (Canis familiaris) CECDNEECDGKEEESQ;CECECDNEECDG;CECECDNEECDGKE;CECECDNEECDGKEEE;DCVEEGEEEQEEEEGE;DCVEEGEEEQEEEEGEEGEEDQ;ECECECDNEECDGK;ECECECDNEECDGKEEESQEEEE;ECECECDNEECDGKEEESQEEEEE;EDQEEEEETEEEAVEEEEPREEENH;EECECECD;EECECECDNEEC;EECECECDNEECD;EECECECDNEECDGKE;EECECECDNEECDGKEEESQ;EEGEECECECDNEECDGKEEE;EELERQQEALR;EEQGEEGEECECECDN;EEQGEEGEECECECDNEECD;EEQGEEGEECECECDNEECDGKEEE;EGEECECE;EGEECECECDNEEC;EGEECECECDNEECDGKEEESQ;EGEGEEEDREEEEEEEEDAGPW;GEEGEECECECD;GEEGEECECECDNEE;PLGQEEQGEEGEECECECD;QEEQGEEGEECECECD;QGEEGEECECECDNEECD;RRGAPIYKRRRRYGPKS 30 30.2 0.97247 0.046699 0 0 0 0 0 0 0 6.16169 0 0 0 0 0 0 0 A0A8P0PFK9 A0A8P0PFK9_CANLF E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) UBE3D Canis lupus familiaris (Dog) (Canis familiaris) EGCTELQLPAEVRL;HLRLGARHGGGCGGDARVPGGAET;SAQGSGREARAAAAAAAARVT 3 14.8 0.99429 -0.15904 8.77597 0 0 0 0 7.86053 0 0 8.41164 0 0 0 0 0 0 A0A8P0PFM0 A0A8P0PFM0_CANLF DDB1 and CUL4 associated factor 16 DCAF16 Canis lupus familiaris (Dog) (Canis familiaris) SEEEENANYLNESSGQEWDSSE 1 10.2 0.97415 0.046699 0 0 0 0 0 0 0 10.2548 0 0 0 0 0 0 0 A0A8P0PFM8 A0A8P0PFM8_CANLF G protein subunit beta 4 GNB4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AGVLAGHDNRV;FVSGACDASSKLWD;SLSPDMRTFVSG 3 10.1 0.99247 -0.14146 0 0 0 7.69857 0 0 11.2804 0 0 9.94991 0 0 0 0 0 A0A8P0PFN1 A0A8P0PFN1_CANLF DNA-directed RNA polymerase subunit POLR2G Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DIVIQQDDEI;VDKNDIFAIGS 2 13.5 1.0027 -0.86202 0 0 0 0 0 0 10.1049 0 0 0 0 0 0 12.8647 0 A0A8P0PFN2 A0A8P0PFN2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) MRPFSSVNFPVM;PVMNKTGSVSK 2 9.7 0.9947 -0.56103 0 0 0 0 0 0 0 0 12.0452 0 0 5.29197 11.0262 0 0 A0A8P0PFQ5 A0A8P0PFQ5_CANLF Centrosomal protein 85 CEP85 Canis lupus familiaris (Dog) (Canis familiaris) AEMESWQKECDS;DPWHPRERSCELSTC;FSKPLPSQ;GPTQQGEGPKAEME;QERVTELESL;STELQERVTELE 6 8.4 1.0032 -1.3822 0 0 0 10.9343 0 0 0 10.5023 7.72042 0 0 0 0 0 0 A0A8P0PFQ7 A0A8P0PFQ7_CANLF Maestro heat like repeat family member 2B MROH2B Canis lupus familiaris (Dog) (Canis familiaris) AAASSTIGLFCIKGTHP;ARDFYRQFCV;DKEIDFHITQ;FNEQMDSYS;ISSKIAKIVSKLI;IYGAVALH;LDHLLDGQD;LPSPQQLLARLLVISI 8 6 1.0014 -2.6713 0 8.05956 4.09339 9.50482 0 0 9.03999 0 10.5163 0 9.22093 9.85223 6.95501 0 0 A0A8P0PFR4 A0A8P0PFR4_CANLF Latent transforming growth factor beta binding protein 4 LTBP4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AAGSECEDVDECEN;ASCLDVDECSEEDLCQSGIC;CCRGAGLA;DVDECATGGRCQHGECAN;ECVDNDECA;EPPPCGPG;GWGGGAAE;LRGGECASPLPGL;PTGFLPTHRPEPPPEPRPG;SYHCTCEPPL;VYTMPLAN;YHAQRLECVDNDECADEEP 12 8.8 0.98944 -0.26299 0 0 0 0 0 0 0 0 0 0 0 0 0 7.53605 0 A0A8P0PFS1 A0A8P0PFS1_CANLF Keratin 14 KRT14 KRT42 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] FGGGSGSG;SCGFGGGA;VSSGSGGG 3 5.4 1.0029 -2.4747 11.9391 14.7351 0 0 0 0 14.6894 0 0 6.97636 0 0 0 0 0 A0A8P0PFS2 A0A8P0PFS2_CANLF Olfactory receptor OR4C10E Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVMAYDRYVAICKPLHYMTIMNRQV;VYMRPAAT 2 10.7 1.0038 -0.80767 0 0 0 0 0 0 13.3859 0 0 0 0 0 0 0 0 A0A8P0PFT5 A0A8P0PFT5_CANLF Kelch domain containing 7B KLHDC7B Canis lupus familiaris (Dog) (Canis familiaris) AGGPERDPYALLS;DTEDDWDGPVLTLLA;GVLVLPGP;GVLVTAAAPPL;LVLPGPYQGGGARGGGAG;RDPSPGKA;VERYDPRT;VERYDPRTDAWTPR 8 8 1.003 -2.48 0 9.15332 0 8.71352 0 0 0 0 9.85025 0 10.6467 0 10.2305 0 10.9314 A0A8P0PFT6 A0A8P0PFT6_CANLF Palmitoyl-protein thioesterase 2 PPT2 Canis lupus familiaris (Dog) (Canis familiaris) palmitoyl hydrolase activity [GO:0098599] DDLYLNASSFLALINGE 1 5.6 0.97647 0.046227 0 0 9.01625 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PFT8 A0A8P0PFT8_CANLF Peptidase S1 domain-containing protein LOC479874 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GEAGGKCGGTQGDLMFHH 1 4.6 0.97972 0.048313 10.3939 0 0 0 0 0 0 0 0 0 0 0 10.6886 0 0 A0A8P0PFU3 A0A8P0PFU3_CANLF LHFPL tetraspan subfamily member 5 LHFPL5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGKGGGGQ;TVYKICAWMQL 2 7.4 0.98931 -0.26592 7.52755 7.32823 0 0 8.8967 0 7.06846 0 7.46033 0 0 7.73992 8.07355 0 9.28748 A0A8P0PFU7 A0A8P0PFU7_CANLF Dynein light intermediate chain DYNC1LI2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; microtubule [GO:0005874] ATP binding [GO:0005524] ELERKFVKDFQDYIEP;IVHKTYGFHFVTPALVVEK;LLLGPNGPAVAAAGDL;LPSGKNILVFGED 4 13.4 0.99604 -0.095022 0 8.99367 0 0 0 0 5.99367 0 0 0 8.56632 0 8.71459 0 0 A0A8P0PFV0 A0A8P0PFV0_CANLF 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (EC 4.1.1.97) (Parahox neighbor) (Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) URAD Canis lupus familiaris (Dog) (Canis familiaris) allantoin metabolic process [GO:0000255]; purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628] carboxy-lyase activity [GO:0016831] LEKHFFDFIDALPQ 1 8 0.99229 -0.20656 0 0 9.87785 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PFV2 A0A8P0PFV2_CANLF Phosphoinositide-3-kinase-interacting protein 1 (Kringle domain-containing protein HGFL) PIK3IP1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] AEAYGSGG;KEVRMLLAWVQ 2 7.4 0.98853 -0.5065 0 10.2217 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PFV7 A0A8P0PFV7_CANLF Calcyon neuron specific vesicular protein CALY Canis lupus familiaris (Dog) (Canis familiaris) clathrin coat assembly [GO:0048268]; G protein-coupled dopamine receptor signaling pathway [GO:0007212] membrane [GO:0016020] clathrin light chain binding [GO:0032051] ATPPGGPPPGEQPGALA 1 3.2 0.98499 -0.23701 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2386 A0A8P0PFW3 A0A8P0PFW3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KPSVGLYSR 1 7.3 0.99247 -0.19146 0 0 0 0 0 0 9.59305 0 0 0 0 0 0 0 0 A0A8P0PFX6 A0A8P0PFX6_CANLF CF120 protein C12H6orf120 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] TSRRGSTP 1 2.7 1.0045 -1.1044 8.61629 0 0 0 0 0 0 0 0 0 0 4.48214 0 0 0 A0A8P0PFY0 A0A8P0PFY0_CANLF Hyaluronan and proteoglycan link protein 2 HAPLN2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] hyaluronic acid binding [GO:0005540] ADGSVRFPITSPRPRCGGLPD;AGCQAGGG;INGIEDESV;PALAAESLRGA 4 9.8 1.0031 -2.4573 8.05039 0 0 0 0 6.65835 8.10066 0 0 9.76383 0 0 8.05783 0 0 A0A8P0PFY6 A0A8P0PFY6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APATAALC 1 10.4 0.98921 -0.26592 3.33242 0 0 0 0 0 0 0 0 0 8.45138 0 0 0 0 A0A8P0PFY8 A0A8P0PFY8_CANLF Growth arrest and DNA damage inducible beta GADD45B Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634] TPGAPTEPPLFT 1 4.9 0.94797 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 4.23097 0 A0A8P0PFZ9 A0A8P0PFZ9_CANLF La-related protein 7 (La ribonucleoprotein domain family member 7) LARP7 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] KKKKKKKK;KKKKRERQE;SKENKDLEVST;TDTDKESVAK;VEKKKRSRV;VLRVSEEKKKKKKKK 6 9.9 1.0029 -1.6624 0 0 9.81813 4.4549 0 3.94897 0 0 0 0 0 8.31918 0 0 9.85999 A0A8P0PG01 A0A8P0PG01_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP31 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] AGSTSSSL;EGAAPDRGGLRSCFPPGPAA;ISLPIPLPHTR;IVLTEMYYDGFHRSFC 4 4.3 0.98739 -0.4676 11.1628 12.2028 0 0 0 0 10.3489 0 0 0 0 0 0 0 0 A0A8P0PG04 A0A8P0PG04_CANLF Myopalladin MYPN Canis lupus familiaris (Dog) (Canis familiaris) AAASASPSSSPVFTLSGTPQTI;GAPSPKVEWYREGT;LDCIVVGI;QTRPDSFPERFNGQAAKIPEPS;SFEQRLMNEIEFRLE 5 6.2 1.0026 -1.1839 6.15731 0 0 0 10.4593 0 0 8.82493 0 0 0 0 10.0898 0 10.3396 A0A8P0PG11 A0A8P0PG11_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" VIISTPSADAPMFVM 1 4.6 0.99401 -0.077099 0 11.3694 0 0 0 0 10.8288 0 0 0 0 0 0 0 0 A0A8P0PG12 A0A8P0PG12_CANLF Potassium voltage-gated channel subfamily E member 1 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324]; membrane raft [GO:0045121] voltage-gated potassium channel activity [GO:0005249] GCLGAPDP 1 3.5 1.0044 -1.1044 0 0 0 8.96353 0 9.32868 0 0 0 11.3198 0 11.6441 0 0 0 A0A8P0PG14 A0A8P0PG14_CANLF von Willebrand factor C domain containing 2 VWC2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] CTICHCTYEEGTWRIE;ETAVIPAGREVKTD;FVVSPCERC 3 12 0.98861 -0.50677 0 0 0 10.7427 0 10.5917 0 0 0 0 0 0 0 0 7.29471 A0A8P0PG16 A0A8P0PG16_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CSCSCSFS 1 9.8 1.0036 -1.1044 0 0 0 0 0 0 0 0 0 2.26864 0 0 0 0 0 A0A8P0PG35 A0A8P0PG35_CANLF Cyclin-dependent kinase inhibitor domain-containing protein CDKN1C Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell cycle [GO:0051726] nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861] EGAGDSPP;GAAIKKLPGPLISD;LLLLLLLFLSSPLPRP;LLLLLLLL;LLLLLLLLFLSS;PPPPPRSQEPLAEPLHSGIPGR 6 19.1 0.94114 0.070491 0 2.92795 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PG39 A0A8P0PG39_CANLF Mitogen-activated protein kinase (EC 2.7.11.24) MAPK7 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] FEPSARISAA 1 1.3 0.9902 -0.26729 0 0 0 0 10.1667 0 0 0 0 0 0 0 0 0 0 A0A8P0PG46 A0A8P0PG46_CANLF Migration and invasion inhibitory protein MIIP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] LQDAQQDAPCGTSW;SPDTVTPSIDSALLCV 2 6.7 0.99535 -0.018133 0 0 0 0 0 0 0 11.4235 0 0 0 0 0 0 0 A0A8P0PG54 A0A8P0PG54_CANLF C-type lectin domain family 2 member L CLEC2L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDWLLYGRK;EEPRDWNTGRQ;VNGVSDDPPLGVQQDGLHMTWVRP 3 10.8 1.0038 -1.0541 0 0 9.1852 6.1503 0 0 0 0 9.30035 0 0 0 0 0 0 A0A8P0PG55 A0A8P0PG55_CANLF alanine transaminase (EC 2.6.1.2) GPT2 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GGGGGGGA;LAAKAKLTEDLF;PARAHPDARVHEPA;TYHFRMTI;VYSPDCRFH 5 9.9 1.0027 -1.4038 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.1754 A0A8P0PG65 A0A8P0PG65_CANLF CACN subunit beta associated regulatory protein CBARP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter binding [GO:0044325] LPHRGMCSRQSAPPAPPPS;LVVVLSLFVGGTLVVLSGVLLLCKR 2 5.4 0.99256 -0.2065 0 0 0 0 8.67352 8.7765 0 0 0 0 0 0 0 0 0 A0A8P0PG67 A0A8P0PG67_CANLF WH2 domain-containing protein LMOD2 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] sarcomere [GO:0030017] actin binding [GO:0003779]; tropomyosin binding [GO:0005523] DEEDEEDEEHEEH;DIEPDHSLPV;EDEEHEEHEE;EVYTEEEDEEDEED;KKKKGKKVKKQPNN;NSEVSEEVYTEEEDEEDEED;VYTEEEDEEDE 7 9 1.0024 -0.95812 9.40535 0 6.7654 6.00452 0 6.14613 7.58961 0 3.43789 0 0 0 0 0 0 A0A8P0PG83 A0A8P0PG83_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) HECTD1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DEDLPEPDEEDDENED;EAGGLNCV;EEDDENEDDNQ;EEVMILRRPS;EEYETKGGRRRTWD;ELTNKEAA;ENVPQTEV;FEEDSKSEFI;KRGRKLKSKLEKTKQKVRTMARDL;QSWSSLVKNNCP;RPAVALIRKLIAVL;RQRRLVRS;SLTCLKEGEIAIHNSDGQQATI;SLVKNNCPD;VELNNRTSRDLAE 15 6.8 0.99696 -5.4615 0 11.8947 5.48494 5.98005 0 9.62037 8.87793 10.9742 9.87411 0 0 0 0 0 6.3597 A0A8P0PG91 A0A8P0PG91_CANLF Golgi SNAP receptor complex member 1 GOSR1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] cis-Golgi network [GO:0005801]; Golgi membrane [GO:0000139] IEETISIAMATKE 1 5.3 0.93906 0.075433 0 0 0 0 0 0 0 0 0 0 0 6.60444 0 0 0 A0A8P0PG92 A0A8P0PG92_CANLF Adenosine deaminase RNA specific ADAR Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] double-stranded RNA adenosine deaminase activity [GO:0003726]; RNA binding [GO:0003723] DLEILDGTRGTVDGP;EKAERMGFTEVTP;FYSHGWPRCSPYKKLTECQL;KETSVNWCLADGYD;KKASDDLGVV;QEAVPEPVKPKPP;TFHDQIAMLSHRCFNA;TTPPIWYLT 8 11.7 0.99632 -0.5813 0 0 6.34768 8.64699 3.57906 6.22489 0 0 0 0 9.68382 8.31651 6.48593 0 0 A0A8P0PG97 A0A8P0PG97_CANLF Basic leucine zipper ATF-like transcription factor 2 BATF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] RSFCFIFFRMTHSRFPPQE 1 6 0.98177 -0.24958 0 0 0 0 0 9.71048 0 0 0 0 0 0 0 0 0 A0A8P0PG98 A0A8P0PG98_CANLF Leucine rich repeat containing 69 LRRC69 Canis lupus familiaris (Dog) (Canis familiaris) EDAWSLQEIT;EIKFLKKLQKLVL;EIKFLKKLQKLVLIRNNIE;GVCGGLQH;IMNELEGKSPF 5 15 1.0024 -1.3906 0 0 0 0 0 0 0 11.047 0 3.52419 0 6.38355 0 11.4918 0 A0A8P0PGA6 A0A8P0PGA6_CANLF Tetratricopeptide repeat domain 12 TTC12 Canis lupus familiaris (Dog) (Canis familiaris) CLQSPFVYEVWAVEVSRKC;YNMSRECYQKILEISPKLQ;YQKILEISPKLQTQV 3 6.1 0.86364 0.15327 0 0 3.42048 0 0 6.75982 0 8.98388 0 0 0 0 0 0 0 A0A8P0PGC9 A0A8P0PGC9_CANLF Kinesin-like protein KIF20A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] IYNELLYDL;QALTTCDDILIKQDQ;QELTAKLEQCRAEL 3 4.6 0.99125 -0.51351 5.5767 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGD7 A0A8P0PGD7_CANLF GINS complex subunit 4 GINS4 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated DNA replication [GO:0006261] chromosome [GO:0005694] ENILVEPETDEQRHCCPQ;LVEPETDEQ;NVALKHMPPNLQV;VECVMEQLDH 4 14.9 1.0017 -0.74896 0 0 0 0 10.3316 0 0 0 11.1938 0 0 0 0 11.747 0 A0A8P0PGE0 A0A8P0PGE0_CANLF Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) HAT1 Canis lupus familiaris (Dog) (Canis familiaris) subtelomeric heterochromatin formation [GO:0031509] "chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]" histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393] CTNTNDFL;LLYYIAGS 2 4.2 1.0023 -0.65785 0 0 12.1443 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGE5 A0A8P0PGE5_CANLF Ninjurin 2 NINJ2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; tissue regeneration [GO:0042246] membrane [GO:0016020] RAAGGSPP 1 3.3 1.0033 -1.1044 9.01042 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGE7 A0A8P0PGE7_CANLF EF-hand domain-containing protein CAPSL Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] KDGLVSKEEFLNYYA;LLTLRPPMSR;RHDREMAIQA;TGDGVITIEDLREVYNVKHHPKYQN 4 28.8 1.0025 -1.1731 0 0 0 0 0 0 0 0 10.9106 0 0 7.15066 0 0 0 A0A8P0PGF3 A0A8P0PGF3_CANLF Transmembrane protein 186 TMEM186 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] EDAGAENK;SDRPQELFMRIQQYSGKQTFYLTLR 2 9.3 0.98793 -0.49298 0 0 0 0 0 0 0 9.40418 10.7709 0 0 0 0 0 0 A0A8P0PGF5 A0A8P0PGF5_CANLF Dihydrouridine synthase 2 DUS2 Canis lupus familiaris (Dog) (Canis familiaris) flavin adenine dinucleotide binding [GO:0050660]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150] IRYAVQYENHYTNT 1 3.1 0.93148 0.060769 0 0 0 8.22622 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGG4 A0A8P0PGG4_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G2E Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] TDWCCHAHDCC 1 7.7 0.98123 0.035491 0 0 0 0 0 0 0 0 0 0 0 4.6412 0 0 0 A0A8P0PGG8 A0A8P0PGG8_CANLF C2H2-type domain-containing protein LOC106559648 Canis lupus familiaris (Dog) (Canis familiaris) EGYKTFWKTSLK;EKLENLESYLV;ENHYECDKCVEVFYQSS;ESEEHQRYHEG;ESYLVHPENNYL;LENLESYLVHPE;PFTEELTL 7 11.8 1.0013 -0.92096 0 0 0 0 0 0 0 9.82346 0 2.80824 10.6218 0 5.40609 0 8.54218 A0A8P0PGH0 A0A8P0PGH0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CSFFFFPLSL 1 8.8 0.9738 0.036176 0 0 0 0 0 0 0 0 0 10.4542 9.34223 9.65987 0 0 0 A0A8P0PGH2 A0A8P0PGH2_CANLF Syntaxin 5 STX5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] SNAP receptor activity [GO:0005484] AIDMMDSRTSQQLQL 1 4.3 0.95156 0.053889 0 0 0 0 0 0 0 0 0 0 6.41812 0 0 0 0 A0A8P0PGH8 A0A8P0PGH8_CANLF Voltage-dependent calcium channel gamma-2 subunit CACNG2 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] KNKKKNKKKALKK;LEGNFKGL 2 6.4 1.0044 -1.0448 5.09022 0 6.38146 0 0 0 0 0 5.64714 0 0 0 0 0 0 A0A8P0PGI6 A0A8P0PGI6_CANLF Cathepsin C CTSC Canis lupus familiaris (Dog) (Canis familiaris) AALRLPRRARR 1 6.9 0.9833 0.035491 0 0 0 0 0 0 2.46712 0 0 0 0 0 0 0 0 A0A8P0PGJ1 A0A8P0PGJ1_CANLF S100 calcium binding protein A11 S100A11 Canis lupus familiaris (Dog) (Canis familiaris) HLQGLQNTNSESREA 1 5.9 0.99202 -0.18373 0 0 0 0 0 10.0367 0 0 0 0 0 0 0 0 0 A0A8P0PGJ2 A0A8P0PGJ2_CANLF Proteinase-activated receptor 1 (Thrombin receptor) F2R Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] plasma membrane [GO:0005886] thrombin-activated receptor activity [GO:0015057] AAYFAYLLC;LVFIWKMKIKKPAVVYMLHL 2 7.2 1.0027 -0.75601 8.9037 0 0 0 0 0 9.2851 0 8.37686 0 0 0 0 0 0 A0A8P0PGK6 A0A8P0PGK6_CANLF Neurite extension and migration factor NEXMIF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DDDQREFQEPS;ESKDAVDPEPGISLKVGDLN;HSSLSEMSP;LFSFDSMA;NKPCSGTELGQFKNPKQ;QITRCESI;SFQDNVRDKTTL 7 5.7 1.0035 -2.3936 5.61742 0 0 11.3536 10.1333 10.8721 0 0 0 0 0 0 0 0 0 A0A8P0PGK7 A0A8P0PGK7_CANLF Calcium homeostasis modulator 1 CALHM1 CALHM2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] HYCSPLSYRQEAYWAQY;NNNVSVLAEEW;QVYSAFDFNCP 3 12.1 0.91575 0.11721 0 0 0 0 4.93249 0 0 0 2.66148 0 0 5.36894 6.40902 0 0 A0A8P0PGN2 A0A8P0PGN2_CANLF SMC5-SMC6 complex localization factor 1 SLF1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of double-strand break repair [GO:2000781] EIKNDLRKHI;FHKTNLKGETALHRACIN;GVTPLHDALSNG;SQIKEELFAI;SSISISSEPLSL 5 6.5 1.0017 -0.96332 0 10.5436 8.60344 0 0 0 0 0 14.4053 9.17759 0 0 0 9.36313 0 A0A8P0PGN4 A0A8P0PGN4_CANLF Napsin A aspartic peptidase NAPSA Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] GASCCPELPG;LSLILSYR;PVLEAGDP;WGPRFLEGSRGTW 4 8 1.0008 -2.735 0 0 0 15.8673 0 0 0 4.68336 6.80271 0 0 0 11.0658 0 0 A0A8P0PGP7 A0A8P0PGP7_CANLF Protein APCDD1 APCDD1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] Wnt-protein binding [GO:0017147] GAEGSWQVGVQQDV;NGNECGAEG;NTSAFRVPGTA;VIRGKVRL;VIRGKVRLR 5 7.4 0.99913 -3.1673 0 0 0 0 9.04273 0 5.64079 0 0 3.52745 0 0 9.20242 4.9241 0 A0A8P0PGR2 A0A8P0PGR2_CANLF Protein inhibitor of activated STAT 1 PIAS1 Canis lupus familiaris (Dog) (Canis familiaris) protein sumoylation [GO:0016925]; regulation of macromolecule metabolic process [GO:0060255] nucleus [GO:0005634] transferase activity [GO:0016740]; zinc ion binding [GO:0008270] DLLHSSRFFPYTSS;DLSIPNVHSSPMPATLSPSTIPQ;ESHSHTVANRSSTD;PMPATLSPSTIPQ;TSLLAAAA 5 9.2 0.98788 -0.34206 12.2856 0 12.361 8.7496 8.40382 0 12.3177 9.71718 0 12.1224 0 12.3428 12.2659 0 0 A0A8P0PGS4 A0A8P0PGS4_CANLF Solute carrier family 25 member 46 SLC25A46 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane fission [GO:0090149] mitochondrial outer membrane [GO:0005741] AASLCSDVILYPLE;HYHLTPFT;LHGVLHYIIS;LILKRKTY;PPPSPLPFSVPP;PVPPPSPLPF 6 8 0.99827 -3.2996 0 10.3977 0 0 8.73816 0 0 0 0 0 8.14349 0 0 0 0 A0A8P0PGT0 A0A8P0PGT0_CANLF Death associated protein kinase 3 DAPK3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] RLRQELHKT;YAAKFIKKRRL 2 4.5 0.98905 -0.22636 0 0 0 0 0 0 0 7.14598 0 0 0 4.24778 0 0 0 A0A8P0PGT6 A0A8P0PGT6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ALATLIRLLARVHVVVL;AVAEGLAALATLIRLLARVH 2 7.1 0.93234 0.094433 0 0 0 0 4.67395 0 0 5.55811 0 0 0 0 0 0 0 A0A8P0PGT7 A0A8P0PGT7_CANLF Spindle assembly abnormal protein 6 homolog SASS6 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] KPAVLPSPSSAYFPG;LEATIKSL;LSLMQSLDDVTRQLNFTQK;VIRLTDETDPFFLY;VQYQQQHEQQ 5 8.5 1.0013 -0.69412 7.61272 10.862 0 8.65889 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGV9 A0A8P0PGV9_CANLF Chromobox 7 CBX7 Canis lupus familiaris (Dog) (Canis familiaris) PRC1 complex [GO:0035102] KGKVEYLVKWKGWPP;PELFLGSHWGSTY;RKPRKAHKYLRLSRKK 3 17.5 0.98981 -0.21274 0 0 0 0 0 0 0 8.46258 0 0 0 0 0 0 0 A0A8P0PGW0 A0A8P0PGW0_CANLF Adaptor related protein complex 1 associated regulatory protein AP1AR Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of cell motility [GO:2000146]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; vesicle targeting, trans-Golgi to endosome [GO:0048203]" cytosol [GO:0005829] AP-1 adaptor complex binding [GO:0035650] EEALYAAQREAARAAKQ;PGLSVGLEREEEQ;SGNDDSTSLDLEWEDEEGMN 3 16.7 0.99499 -0.018637 0 0 0 0 0 0 0 0 0 0 9.36584 0 0 0 0 A0A8P0PGW8 A0A8P0PGW8_CANLF Potassium two pore domain channel subfamily K member 5 KCNK5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] DYHPLIFQNVSITF;KAIKKRRRRR;RMPSLEEVSQTLRSK;VPLCLTWIS 4 9.7 1.0037 -1.1054 8.25772 10.0231 0 0 0 0 0 0 0 0 0 0 0 0 6.51091 A0A8P0PGX6 A0A8P0PGX6_CANLF CFAP97 domain containing 1 CFAP97D1 Canis lupus familiaris (Dog) (Canis familiaris) DTKPPAAHTHHI;IFHKNRIQIVKPAVDTKP 2 16.8 0.93262 0.098753 0 0 4.69839 0 0 8.16159 0 0 0 0 0 0 0 0 0 A0A8P0PGY8 A0A8P0PGY8_CANLF Apolipoprotein C-III (Apolipoprotein C3) APOC3 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] chylomicron [GO:0042627]; very-low-density lipoprotein particle [GO:0034361] lipid binding [GO:0008289] ALPRPRLKALRLPHS;DSASEAKPTPASDA;EEDPSLLGLM;LEEEDPSL;LEEEDPSLL;LEEEDPSLLG;LEEEDPSLLGL;LEEEDPSLLGLM;LEEEDPSLLGLMQ;LEEEDPSLLGLMQG;LEEEDPSLLGLMQGY;LEEEDPSLLGLMQGYMQH;LEEEDPSLLGLMQGYMQHA;MTDSFSSLKDY;PIWWVFCSVP;PSLALPRPRLKALR;STFKGKFTGF 17 28.2 0 92.424 14.0707 13.6512 13.9752 11.9351 10.7161 11.7412 13.3963 14.095 13.6437 14.5787 14.0749 14.6632 13.5367 13.5491 13.4151 A0A8P0PGZ1 A0A8P0PGZ1_CANLF Protein phosphatase 2 regulatory subunit B'alpha PPP2R5A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] RRCRRRRRRRRRRRRRRG 1 3.6 0.97289 0.048313 0 8.23021 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PGZ7 A0A8P0PGZ7_CANLF Glucocorticoid induced 1 GLCCI1 Canis lupus familiaris (Dog) (Canis familiaris) GAGGGGGG;GGGGGGGG;PSAGSGSGAGGGGGGGGGGV;RSASWGSADQLKEQIAKLRQQLQ;SPVCRVDRPKSQ;SRVPCNVEGISPEL;TVEQLSSRVSFT 7 14.5 0.93696 0.074447 12.877 12.6766 0 11.5494 11.7259 0 12.5294 10.8223 0 0 12.8563 12.7996 9.64348 12.5999 12.7128 A0A8P0PH02 A0A8P0PH02_CANLF PVR related immunoglobulin domain containing PVRIG Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of T cell receptor signaling pathway [GO:0050860] membrane [GO:0016020] signaling receptor activity [GO:0038023] EACGNPFLNTNQGEANEGWEG;GTPEVWVQVQMEAAKSP;ILGVSGVLLFGC 3 15 0.98706 -0.32682 7.30314 0 10.7119 0 0 0 0 0 11.1895 0 0 0 0 0 0 A0A8P0PH03 A0A8P0PH03_CANLF Synaptotagmin like 5 SYTL5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267] CSECRVSGLDGS;PQWNHTFMFSGLNPQDIKNV;RTDAYVKSY 3 5.9 1.0019 -1.0015 0 7.44708 0 0 8.33802 0 0 0 0 0 0 9.98826 0 0 0 A0A8P0PH08 A0A8P0PH08_CANLF Amyloid beta protein binding family B member 2 APBB2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta binding [GO:0001540] ASPSSPDETADIWSDHS;MPGSLLMTSFFFPGD;VLSLIDTL;WVEMAEEDLAP 4 6.7 1.0028 -0.72143 0 8.46622 0 0 0 0 0 0 0 0 0 0 4.7339 8.28072 10.6145 A0A8P0PH29 A0A8P0PH29_CANLF SH3 and multiple ankyrin repeat domains 1 SHANK1 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic density [GO:0014069] AAGGGGGG;ASPPAARRSL;FDIRGSPTGGA;FEKGVPYLEFR;GGGGGGGG;GGSGTPGPPYHPQLMT;GVGPLLLQLGP;LSESLQDVLNY;PFQVAVIAGN;TRHPDMDEVHK;VGSYDSFDAPSL;VGSYDSFDAPSLMD;VLSIGEGGFWEGQVKGRIG;VPGSEDIPPPPT 14 7 1.0028 -2.5205 0 10.7986 0 10.514 0 0 13.0106 13.0355 0 0 8.19505 7.65263 0 10.446 0 A0A8P0PH30 A0A8P0PH30_CANLF T-complex 11 like 1 TCP11L1 Canis lupus familiaris (Dog) (Canis familiaris) EQDLEDAVEGSDEALQK;QQSVEYERKKFQQLLE 2 6.9 0.92698 0.09546 0 0 0 0 0 0 0 11.5216 0 0 0 0 0 0 0 A0A8P0PH35 A0A8P0PH35_CANLF Metastasis associated 1 MTA1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] AECTARLPEASQSP;ANMYRVGDYVYF;GVVNGAGA;KQIDQFLVVARSVGT;LTQGWGAAAKE;TKLTRIARRLCREILRPW 6 7.8 0.98285 -0.25158 0 0 0 0 8.60907 0 0 0 0 0 0 0 0 0 0 A0A8P0PH39 A0A8P0PH39_CANLF Arginine vasopressin-induced protein 1 AVPI1 Canis lupus familiaris (Dog) (Canis familiaris) EALRRLRRKRPPRLK;EGWFQLGASPGSTRRLS;LRRLRRKRPPRLKPLA 3 13.9 0.85079 0.14933 0 0 0 9.3845 0 0 11.1224 0 6.64429 0 0 0 0 0 0 A0A8P0PH49 A0A8P0PH49_CANLF Armadillo like helical domain containing 4 ARMH4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAPSLFPALPD;EEDEEEEEEEEEDEEEDEEDKEGET;ESEGDRSTSPENEIVFSMGYEQD;PSATSLNKVFP;VGVGIAGA;VTDQNSFI 6 10.7 0.98654 -0.38696 0 4.89947 8.93074 0 14.3415 14.4315 0 11.893 0 0 0 11.7279 0 9.1755 0 A0A8P0PH53 A0A8P0PH53_CANLF Transmembrane protein 200A TMEM200A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PSIDHITE;SSVSVFGL;VGTAFPRNHSVGESL 3 6.3 1.0029 -2.1549 9.55624 9.47472 0 0 7.39686 0 0 0 0 0 0 0 0 0 0 A0A8P0PH55 A0A8P0PH55_CANLF Protein YIPF YIPF4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] Golgi membrane [GO:0000139] AQGPRDAAAGPA;ELDIDLKDIYYK;LTIFLLARVL 3 12.3 1.0012 -0.94453 0 0 0 0 0 0 14.8761 0 0 0 0 0 0 0 6.63125 A0A8P0PH64 A0A8P0PH64_CANLF Family with sequence similarity 171 member A1 FAM171A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ASGTSGTDGVAFIKFQY;DDEEEDEEDQ;DDEEEDEEDQGEDKKSPWQK;LLLYYCRRKCLKPRQ;QEDDEEEDEEDQGE;SLQEETTKR 6 8 1.0033 -1.0304 10.4207 0 6.72301 0 0 5.18495 6.54662 0 0 0 0 0 0 0 9.42859 A0A8P0PH71 A0A8P0PH71_CANLF Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) DUSP18 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634] MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017] FFDPIADHIHSVEMK;VSGLSQITSSLYISNGVAANNKLM 2 20.7 0.94963 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2456 0 A0A8P0PH75 A0A8P0PH75_CANLF Ubiquitin specific peptidase 54 USP54 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] CIKGHYQPLLLLYA;FLSPDVLMPSMAGEPH;HLDIFRRS;KQSELYLVGMICYYGK;LSVPQHNS;LWHLDIFR;PDDDWRQTSYAPQS;PQLYPPQPQFLSPDVLM;SPCVGKGG;SWKRNYFSGGRG;VLWHLDIFRR 11 6.8 0.99667 -4.6912 10.3529 11.0429 12.831 8.16952 12.9088 0 0 7.18388 8.30172 8.92181 0 0 11.6746 8.96006 0 A0A8P0PH82 A0A8P0PH82_CANLF Two pore segment channel 3 TPC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] FARDHYCKNNFNDLA;FRLYYFYNHWTMQVAIYFF;ILRILRLLRIIVSIQRFRLIVT;IVLILRILRLLRIIVSIQRF;LDIVLILRILRLLRIIVSIQ;LILRILRLLRIIVSIQ;LRILRLLRIIVSIQRFRLI;QRMVRHRIFVWVYDVI;SEVETAIEKKIQ;SFHIVVVILIVNIFIAF;VLILRILRLLRI 11 14.4 0.98638 -0.45135 0 0 0 5.86537 0 11.7584 5.10404 10.8909 6.83971 0 0 8.61886 11.9962 0 0 A0A8P0PH83 A0A8P0PH83_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALVKRLLLLLASNFALS 1 19.1 0.97844 0.046227 0 0 0 0 0 0 0 0 0 3.76691 0 0 0 0 0 A0A8P0PH89 A0A8P0PH89_CANLF SP-RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of macromolecule metabolic process [GO:0060255] zinc ion binding [GO:0008270] RRRAPGPS 1 5.3 1.0037 -1.1044 0 0 0 7.16148 7.03881 0 0 0 0 0 0 0 0 0 0 A0A8P0PH90 A0A8P0PH90_CANLF Tudor domain-containing protein 5 TDRD5 Canis lupus familiaris (Dog) (Canis familiaris) germ cell development [GO:0007281] cytoplasm [GO:0005737] EDKWWYRV;RRRVPYRGRVPPILPAV;TSRRLLHWY;VISVEQTRAGSLL;VTVSPCGDGTII 5 6 0.9897 -0.52748 0 0 16.2115 9.87598 0 9.453 16.4073 0 0 0 0 0 0 0 6.42366 A0A8P0PH94 A0A8P0PH94_CANLF mRNA export factor GLE1 (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) GLE1 Canis lupus familiaris (Dog) (Canis familiaris) poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031] nuclear pore [GO:0005643] EIARACEDKRRQDEEAAQEKQ;KEFQDLREVMEKSSR;LSEMASEQL;SETAVSSRS 4 8.2 1.0029 -1.889 0 0 0 0 9.83136 0 9.77439 0 8.18572 7.4266 9.2559 0 0 0 0 A0A8P0PHA6 A0A8P0PHA6_CANLF Coiled-coil domain containing 157 CCDC157 Canis lupus familiaris (Dog) (Canis familiaris) AVLLELVIDRLLLLL;EKQGLEQATTDLQLTIS;ETSDLKMKVATLEGELE;LPQTCQELDSLP;LPSSRTPSAGRTLPC 5 11.5 0.98777 -0.35044 0 0 0 0 0 0 0 0 11.5629 0 0 0 6.16948 11.0442 10.305 A0A8P0PHB8 A0A8P0PHB8_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRO Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] ISVLAILSTLLIGLL;LLLVTLIILRKK;LSTLLIGLLLVTLIILRKK;MHFNYTAWPDHGV;QEPISVSSHVVTISSLLPATA;STLLIGLLLVTLIILRKK;TEYLTVDEEAH;TLLIGLLLVTLIILRKKH;TLLIGLLLVTLIILRKKHL;YHGLYYIITLVV 10 7.9 0.98882 -0.52328 0 0 0 5.65587 6.68061 4.21311 3.15408 0 4.87809 0 20.1983 4.80162 0 0 0 A0A8P0PHC4 A0A8P0PHC4_CANLF Ring finger protein 25 RNF25 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin protein ligase activity [GO:0061630] GAGPNQQR;RQQEERKRLYQRQ 2 4.8 1.0042 -1.0447 0 0 0 0 0 0 0 0 0 9.07786 0 0 7.77406 0 0 A0A8P0PHD0 A0A8P0PHD0_CANLF small monomeric GTPase (EC 3.6.5.2) RAB27B Canis lupus familiaris (Dog) (Canis familiaris) late endosome [GO:0005770]; membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] FDLTSQQS;TDNKFNPKFITTVGIDFREKRV 2 13.8 1.0032 -1.0569 0 0 0 0 0 0 0 0 0 0 8.91522 0 0 0 10.5101 A0A8P0PHD8 A0A8P0PHD8_CANLF Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) YARS1 Canis lupus familiaris (Dog) (Canis familiaris) tyrosyl-tRNA aminoacylation [GO:0006437] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831] AEKYLPALGYSK;DEKWGGNKTYTVYLD;VALNKLLDPIREKFN 3 8.8 0.99517 -0.017538 0 0 0 0 5.87509 0 11.8346 0 9.53397 0 0 0 0 0 0 A0A8P0PHD9 A0A8P0PHD9_CANLF ERCC excision repair 6 like 2 ERCC6L2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787] DLQAIDRAYRIGQC;ETLIKRIC;IKTAKNKAS;KFLDGVQEVAYIHSNQTVIGS;VENKKIKNP;YFEAVQGS;YTINRYLRD 7 5.1 0.99923 -3.1121 0 10.8571 0 0 0 0 3.64189 0 10.4928 0 10.3311 4.56151 0 12.7988 0 A0A8P0PHF1 A0A8P0PHF1_CANLF ADAM metallopeptidase domain 18 ADAM18 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] DPDIPLLAENY;ECDCGSQEECQFKKC;EECDCGSQEECQF;EPNEECDCGSQEECQ;HSESSYFKMHCHYQGYVA;LSSQYDYMGSEMMAVTQ;LSSQYDYMGSEMMAVTQKIIQ 7 10.2 0.62338 0.34719 4.62761 0 0 6.59237 6.14753 7.64321 7.92505 0 0 0 0 4.04946 0 9.14382 0 A0A8P0PHF2 A0A8P0PHF2_CANLF Chromosome 28 C10orf90 homolog C28H10orf90 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] LVCVSPTSYPYAHPRPSAR;PATPEPPETPD;VEDRAFSDVGVNQ 3 5.8 0.98734 -0.46336 0 0 9.29313 0 0 0 0 0 0 12.8418 0 0 0 0 0 A0A8P0PHF6 A0A8P0PHF6_CANLF Rho GTPase activating protein 10 ARHGAP10 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] SHLQEADIQVEQN;VEELMNKIRQNP 2 3.4 0.98679 -0.38478 9.6151 0 10.3049 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PHG3 A0A8P0PHG3_CANLF Zinc finger protein 250 ZNF250 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ACMGQDSSPCPWECENQGENQ;CENQGENQERDLGV;DFHLPQKSRDQVMAAARL;GSGHSDNYRHDHMPACMGQD;QDSSPCPWECENQGENQERDLGV 5 10.6 0.98675 -0.38003 0 7.89651 0 0 0 0 7.89451 9.1046 8.21189 6.65062 10.5823 0 0 0 0 A0A8P0PHG6 A0A8P0PHG6_CANLF Synapsin II SYN2 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269] synaptic vesicle [GO:0008021] ATP binding [GO:0005524] APAPAAARKAKVLLV;CFRGKKVLGDYDIKVEQA;GQPQGMQPP;SVGSSFFSSLSQAVKQ 4 10.9 0.98884 -0.2605 0 0 0 0 0 0 9.27202 9.36757 9.102 0 0 0 0 0 0 A0A8P0PHH0 A0A8P0PHH0_CANLF Mitogen-activated protein kinase kinase kinase 9 MAP3K9 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase activity [GO:0004672] EKPRVKKRKGK;GGGGGGGG;GGGGGGPG;KRGGPGGG;PAAGRRGGGAVQGLAGVRRRGLVD;VLLWELLTGEV 6 6.4 1.003 -1.0276 9.07347 0 0 0 0 4.45694 8.05507 0 0 0 0 0 0 0 0 A0A8P0PHH1 A0A8P0PHH1_CANLF Diaphanous related formin 1 DIAPH1 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] AAFRRKRGPRQANRKAG;AAGGDGGK;ENIKPEIVSVTAACEELRKSESFSS;FRMAYQEIKNV;LAHVEKASRVSAENLQKNLDQMK;LLAKKDQEGGEEKKSVQKK;LLASELTKDNAMTAVPS;LVRNDYEARP;MDLHNFKNMFMQAVKENQKRRETEE;TGEVAKLSKELEDA;VQKKKVKELK 11 13.8 1.0036 -2.0311 8.80578 4.61648 0 6.94052 0 0 12.8025 12.3013 0 0 0 12.7907 4.33185 0 8.5895 A0A8P0PHH7 A0A8P0PHH7_CANLF Transcription factor SOX SOX11 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AAGGGGGG;DEDDEDDEDDDELQ;EAERLRLKHMADYPDYK;FLDEDDEDDEDDDEL;GGGGGGGA;GGGGGGGG;SRSVSTSSSSSSSSSSSSG;SSSSSGGEDADDLMFDLSL 8 19.1 0.95017 0.049772 9.76348 0 0 0 0 0 0 0 0 0 0 9.39904 0 0 0 A0A8P0PHI0 A0A8P0PHI0_CANLF Collagen type I alpha 2 chain COL1A2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix structural constituent [GO:0005201] ERGYPGNIGPVGAVGAPGPHGPV;ETLLTPEG;GVMGPPGP;NPGPAGPA;PGAPGPKGE;TAGASGPGGLPGE;VGPVGAVG 7 6.1 0.98886 -0.2623 0 12.9535 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PHI9 A0A8P0PHI9_CANLF Polysaccharide biosynthesis domain containing 1 PBDC1 Canis lupus familiaris (Dog) (Canis familiaris) GEEKEKEANKEIHKSSEI 1 8.2 0.97561 0.048313 0 6.2786 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PHK6 A0A8P0PHK6_CANLF Cytosolic fatty-acid binding proteins domain-containing protein RBP1 Canis lupus familiaris (Dog) (Canis familiaris) retinoic acid biosynthetic process [GO:0002138]; vitamin A metabolic process [GO:0006776] cytosol [GO:0005829] lipid binding [GO:0008289] SGSGPEVG 1 2.4 1.0039 -1.1044 0 0 0 0 0 0 0 9.10842 9.14496 2.00867 1.20333 0 0 0 0 A0A8P0PHK9 A0A8P0PHK9_CANLF Methylmalonyl-CoA epimerase MCEE Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ISFQKEGYQWL 1 6 0.98402 0.035491 0 0 0 0 0 0 0 0 9.76175 0 0 0 0 0 0 A0A8P0PHL5 A0A8P0PHL5_CANLF PWWP domain containing 3B PWWP3B Canis lupus familiaris (Dog) (Canis familiaris) IVNAKGTEN;PEAIICSISAVDGL;QDTFRNLFPKLQNENPAEQMVVT;SLGYRERE;TLIRDDKIKFILEVLLPE 5 10.1 1.0045 -1.0939 0 0 0 0 0 8.67839 0 4.58862 8.0789 0 0 9.89848 11.9127 0 0 A0A8P0PHM4 A0A8P0PHM4_CANLF Phosphofurin acidic cluster sorting protein 1 PACS1 Canis lupus familiaris (Dog) (Canis familiaris) ILVNTADWQGQYVAELL;IWMHAEEREESKDKRRDSTPYG;KVKKTRRKLTSASAITRQPNI;LSQDEIVLGTKA;NKPIWMHAEERE;TPYGEYGSWYKACKVDS;VEDSPSTAGDGDDSPV;YSLSSQPIDHEGI 8 7.5 1.0023 -0.76498 0 0 0 5.72181 0 0 0 0 0 8.34314 12.2166 5.5335 13.725 0 11.0189 A0A8P0PHM9 A0A8P0PHM9_CANLF Transmembrane protein 92 TMEM92 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PERVRTSTFEPPP;PYLPIVQIFRATSD 2 16.8 0.99499 -0.15309 0 0 0 0 0 0 0 5.62176 0 0 0 0 0 0 0 A0A8P0PHN3 A0A8P0PHN3_CANLF Eph LBD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] LQLHRSQWDAITEMDEHNRPI;NWLRTNWISRDAAQKIYVEMKFTL 2 18.8 0.98996 -0.20536 0 0 9.57448 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PHN6 A0A8P0PHN6_CANLF Mammalian defensins domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952] extracellular region [GO:0005576] CCGCGGCGGCSSGCGGCSSGCG;CCGCGGCGGCSSGCGGCSSGCGGCG;CCPCCCGCCG;CCPCCCGCCGGCC;CCPCCCGCCGGCCS;CCPCCCGCCGGCCSA;CCPCCCGCCGGCCSAPVVC;CCPCCCGCCGGCCSAPVVCCC;CCSSCCPCCC;CCSSCCPCCCGCCG;CCSSCCPCCCGCCGG;CCSSCCPCCCGCCGGC;CCSSCCPCCCGCCGGCCS;CCSSCCPCCCGCCGGCCSA;CCSSCCPCCCGCCGGCCSAP;CCSSCCPCCCGCCGGCCSAPV;CGCGGCGGCSSGCGGCSSGCGGCGG;CGCSSCGCGKGCCQQKCCQ;CGGCCSAPVVCCCRRSCGCSS;CGGCGGCGG;CGGCSSGCGGCGGCGGCGGCGGS;CPCCCGCCGGCC;CPCCCGCCGGCCSAPVVC;CRCYRVGCCSSCCPCCCGCCGGC;CSSCCPCCCGCCGGCCSA;CSSCCPCCCGCCGGCCSAP;CSSCCPCCCGCCGGCCSAPVVCC;CSSGCGGCSSGCGGCG;CSSGCGGCSSGCGGCGGCGG;CSSGCGGCSSGCGGCGGCGGC;CTTCRCYRVGCCSSCCPCCCG;CYRVGCCSSCCPCCCGC;CYRVGCCSSCCPCCCGCC;CYRVGCCSSCCPCCCGCCG;CYRVGCCSSCCPCCCGCCGGCC;CYRVGCCSSCCPCCCGCCGGCCSA;GCCGCGGCGGCSSGCGGCSSGC;GCCGGCCS;GCCSSCCPCCCGC;GCCSSCCPCCCGCCGGC;GCCSSCCPCCCGCCGGCC;GCCSSCCPCCCGCCGGCCSA;GCCSSCCPCCCGCCGGCCSAPV;GCCSSCCPCCCGCCGGCCSAPVVC;GCGGCGGCGGCGGC;GCGGCGGCSSGCGGCSSGCGGC;GCGGCSSGCGGCSSGCGGC;GCSSGCGG;GGCGGCGGC;GSCTTCRCYRVGCCSSCCPCCCG;GSCTTCRCYRVGCCSSCCPCCCGCC;MGCCGCGGCGGCSSG;MGCCGCGGCGGCSSGC;MGCCGCGGCGGCSSGCG;MGCCGCGGCGGCSSGCGGC;MGCCGCGGCGGCSSGCGGCS;MGCCGCGGCGGCSSGCGGCSSG;PCCCGCCGGCC;PCCCGCCGGCCSAPVVCC;RCYRVGCCSSCCPCCCGCCGG;RVGCCSSCCPCCCGCCGGCC;RVGCCSSCCPCCCGCCGGCCS;RVGCCSSCCPCCCGCCGGCCSAP;SCCPCCCGCC;SCCPCCCGCCGGCCSAP;SCCPCCCGCCGGCCSAPVVCCC;SCCPCCCGCCGGCCSAPVVCCCR;SCGCGKGC;SGCGGCGGCGGCGGCGGSCTTC;SGCGGCSSGCGGCGGCGG;SGCGGCSSGCGGCGGCGGCG;SSCCPCCCGCC;SSCCPCCCGCCG;SSCCPCCCGCCGG;SSCCPCCCGCCGGC;SSCCPCCCGCCGGCCSA;SSCCPCCCGCCGGCCSAPV;SSCCPCCCGCCGGCCSAPVV;SSCCPCCCGCCGGCCSAPVVCCC;SSGCGGCGGCGGCGGCGGSCT;SSGCGGCGGCGGCGGCGGSCTTC;TCRCYRVGCCSSCCPCCCGCCG;VGCCSSCC;VGCCSSCCPC;VGCCSSCCPCC;VGCCSSCCPCCC;VGCCSSCCPCCCGC;VGCCSSCCPCCCGCC;VGCCSSCCPCCCGCCGG;VGCCSSCCPCCCGCCGGC;VGCCSSCCPCCCGCCGGCCSA;VGCCSSCCPCCCGCCGGCCSAPV;VGCCSSCCPCCCGCCGGCCSAPVV;YRVGCCSSCCPCCCGCC;YRVGCCSSCCPCCCGCCGGCCS;YRVGCCSSCCPCCCGCCGGCCSAP 96 89.6 0.99097 -0.29701 0 0 0 0 5.75486 6.02558 0 0 3.27769 0 0 0 0 10.0228 5.55915 A0A8P0PHP4 A0A8P0PHP4_CANLF Hippocalcin-like protein 4 HPCAL4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EMLEIIEAIYKMVGTVIM;VIMMRMNQDG 2 13.1 1.0033 -0.83731 0 0 0 0 0 0 0 0 11.7741 7.66966 0 0 0 0 0 A0A8P0PHP7 A0A8P0PHP7_CANLF Epsin 2 EPN2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] AAPASTSDPWPPFVRFPGCLPK;ATGMSSNQITFGRGSSQPNLS;GVPTGTSTHSVP;PNAALVNLDSLVTRPAPPAQSL 4 12.6 0.9875 -0.37766 0 0 0 0 0 11.1901 0 0 8.19741 0 0 0 12.429 0 0 A0A8P0PHP8 A0A8P0PHP8_CANLF Uncharacterized protein LOC102153605 Canis lupus familiaris (Dog) (Canis familiaris) EVGKGSPYSSPPPHPAP 1 2.3 0.97865 0.046227 0 0 0 0 0 0 0 0 4.46186 0 0 0 0 0 0 A0A8P0PHQ7 A0A8P0PHQ7_CANLF Collagen type XXII alpha 1 chain COL22A1 Canis lupus familiaris (Dog) (Canis familiaris) AYFASLAAR;DSVPIDFDLQRIVIYCDS;GPPGENGV;GPRGPTGAPGAKGQEGPRGAP;TGDALRFITRHSFS 5 4.4 1.0021 -1.8274 0 0 0 0 0 9.39566 0 10.5908 0 0 0 0 0 8.95268 6.44521 A0A8P0PHS4 A0A8P0PHS4_CANLF Acyl-coenzyme A thioesterase THEM4 (EC 3.1.2.2) (Thioesterase superfamily member 4) THEM4 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; lipid metabolic process [GO:0006629] mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; ruffle membrane [GO:0032587] hydrolase activity [GO:0016787] EVLHVDHSLPNPSWN;VINCQLDRV 2 10.7 1.0017 -0.75031 0 0 0 0 10.0825 0 0 0 8.32805 0 0 0 0 0 0 A0A8P0PHT1 A0A8P0PHT1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) TFLSAPTF 1 11.4 0.98943 -0.22671 0 0 0 0 0 0 0 0 0 0 9.41071 0 0 0 0 A0A8P0PHT7 A0A8P0PHT7_CANLF Lysosomal acid phosphatase (EC 3.1.3.2) ACP2 Canis lupus familiaris (Dog) (Canis familiaris) lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765] LFPPNGMQRFNPNISWQPIPV;PITEDRQAQ 2 18.5 1.004 -0.80421 0 0 0 0 0 0 0 0 0 0 8.82703 0 0 0 0 A0A8P0PHU9 A0A8P0PHU9_CANLF Scaffold attachment factor B SAFB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] DGWGGYGS;DMMDISVLDEAEIDNGSVAD;DTSSSDFTILQEIEEPSLEPENE;EWEQRMQAQWEREERERLEI;GVPVISVKT;ILQEIEEPSLEPENEKILDI;LEIARERLAFHRH;REQERIHREREELRRQQELRYEQE 8 11.3 1.0021 -1.2215 0 7.93281 12.8507 5.03826 0 3.0951 5.60899 0 9.81954 6.96532 10.7118 0 0 9.09916 8.41028 A0A8P0PHV1 A0A8P0PHV1_CANLF FAD-binding PCMH-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]" GNVDEAFK 1 0.8 0.98892 -0.26431 0 0 0 0 0 0 0 0 0 0 0 11.2909 0 0 0 A0A8P0PHY4 A0A8P0PHY4_CANLF Ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TASFHYPGGGAKY;VKAKYLTPPFVTMTSPS;WNYDQDVDTPNMDRLA 3 9.8 0.98872 -0.30747 15.2779 15.523 15.3344 11.4102 11.6622 0 15.3579 15.4011 15.4226 15.105 14.8019 14.9262 13.7617 15.2951 15.3335 A0A8P0PHY9 A0A8P0PHY9_CANLF WD repeat domain 11 WDR11 Canis lupus familiaris (Dog) (Canis familiaris) ALFVEACLKY;KKALNKVKILITQEKPS;LSFATSTP;NDCLQLAYLP 4 3.8 1.0033 -2.2811 0 5.81309 0 0 5.68986 0 0 0 5.70282 0 6.47555 6.64803 7.50486 12.1132 5.50322 A0A8P0PHZ0 A0A8P0PHZ0_CANLF phosphoinositide 5-phosphatase (EC 3.1.3.36) INPP5B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; phagocytic vesicle membrane [GO:0030670] inositol phosphate phosphatase activity [GO:0052745] KVKLIRLVGIMLLLYVK;PSLPPLTISKHDV;QEDLFQQPGLRSE 3 5.7 0.98669 -0.45752 0 11.9339 0 0 0 3.13245 0 0 0 0 0 0 0 9.65569 0 A0A8P0PHZ2 A0A8P0PHZ2_CANLF Protein Wnt WNT9A Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] GPSAPRLTGSEPLT;VGRGVHRTG 2 5.3 0.99296 -0.55478 0 0 0 0 0 0 0 9.47895 0 0 0 0 0 0 0 A0A8P0PI02 A0A8P0PI02_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GLLAGVDALV 1 3.3 0.94687 0.078165 0 0 0 0 0 0 8.25465 0 0 0 8.26566 0 0 0 0 A0A8P0PI07 A0A8P0PI07_CANLF Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) CYBA Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] heme binding [GO:0020037] AFLHLGLSVPAGFL;GAGGAGRS;LPGGAGRG 3 8.8 0.99391 -0.060956 0 0 0 0 0 0 0 0 0 0 0 0 11.8317 0 0 A0A8P0PI09 A0A8P0PI09_CANLF Filaggrin Canis lupus familiaris (Dog) (Canis familiaris) structural molecule activity [GO:0005198] ASSTRERQ 1 2.9 0.98406 -0.2438 0 0 12.7983 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PI10 A0A8P0PI10_CANLF Actin-related protein 2/3 complex subunit 3 Canis lupus familiaris (Dog) (Canis familiaris) Arp2/3 complex-mediated actin nucleation [GO:0034314]; regulation of actin filament polymerization [GO:0030833] Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; membrane [GO:0016020] actin binding [GO:0003779] ETKDTDIVDEAI;KNYEIKNEADRTLIYIYIYIYIHIY;YENNNHLLQFKGP 3 31.2 0.98919 -0.52218 0 0 0 0 0 0 0 0 0 0 10.3224 0 0 7.29315 0 A0A8P0PI20 A0A8P0PI20_CANLF Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3 Canis lupus familiaris (Dog) (Canis familiaris) hyaluronan metabolic process [GO:0030212] extracellular region [GO:0005576] serine-type endopeptidase inhibitor activity [GO:0004867] AGSKVTFELTYEELLKRRKGKYE;FFQPFDFKVSDIH;KHFEIEADIY;NVGESRPEKIQENV;RRIYEDSDANLQLQ;VTYPGNVKEKE 6 12.2 1.0038 -0.80558 8.01039 12.0129 10.9463 7.8936 0 8.03348 0 0 0 0 0 0 0 9.15152 0 A0A8P0PI49 A0A8P0PI49_CANLF Cyclin I CCNI Canis lupus familiaris (Dog) (Canis familiaris) EAYSSAGEEEEEEEEEEEEKN;RIPVLKVL;TPLDFLHIFHAIAVSTRPQLLFS;YPETFALASSLL 4 17.4 0.97379 0.047166 0 0 0 0 0 0 0 0 0 0 7.17602 0 0 0 0 A0A8P0PI54 A0A8P0PI54_CANLF Pericentrin PCNT Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737] molecular adaptor activity [GO:0060090] AEHGLAEELEGLR;AERGREDPVL;DLEQLQQRRERENQEGTNLISMLK;EDSALRREVECLTQE;EEIRRLEETNASCRREA;ELADRQVMIQ;ELLWYLGQS;EQSEARKQSEKDRAALLSQMKVF;ESPAHHALLR;LETILAAF;QILSLSHEVE;QVMIQEEEIRRLEETNASCRREAA;VEDKVELQE;VEREHEREEF;VPSLPLTPCSDALSLDA 15 5.8 0.99695 -4.1261 0 10.8955 10.1575 9.39977 9.99873 9.5095 11.7367 11.3421 0 5.54606 11.0289 10.9169 0 10.857 13.4384 A0A8P0PI69 A0A8P0PI69_CANLF Solute carrier family 12 member 7 SLC12A7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] chloride:monoatomic cation symporter activity [GO:0015377] EQESFCEGKNM;GVILFLRLTWIVGAAGV;NHSEMEQESFCE;QCPPSPCPP 4 12.9 1.0048 -0.80421 0 0 0 0 0 0 0 0 0 8.84194 0 0 0 0 0 A0A8P0PI73 A0A8P0PI73_CANLF ZFP30 zinc finger protein ZFP30 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] LPTYRKLPSL;QLTQHQSIHFGEKPYKCKECEKTFR;YECKECGKAFRVRGQLNLH 3 10.5 1.0037 -0.8302 0 0 9.55346 0 0 0 9.81367 0 0 0 0 0 9.67014 0 0 A0A8P0PI89 A0A8P0PI89_CANLF Apolipoprotein D (Apo-D) APOD Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; lipid transport [GO:0006869]; response to stress [GO:0006950]; tissue regeneration [GO:0042246] lipid binding [GO:0008289] RWYEIEKIPVSF 1 7.4 0.99008 -0.26695 0 0 0 0 0 0 0 0 0 9.35971 0 0 0 0 0 A0A8P0PI95 A0A8P0PI95_CANLF Transmembrane protein 214 TMEM214 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] TKKVATLTNQ;VDPLSASVW 2 3 1.0025 -1.1231 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4322 0 A0A8P0PIB2 A0A8P0PIB2_CANLF Alpha-mannosidase (EC 3.2.1.-) MAN2A2 Canis lupus familiaris (Dog) (Canis familiaris) mannose metabolic process [GO:0006013] membrane [GO:0016020] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] DLIFHSSRTNNLE;GVRLLRSLVNLKQVI;GVWKQGFDISYS;MSSLVDIRD;PDEANSHYFALIDQ;SLTLLYPLAA;YSYDVPHTCGPDP 7 7.3 1.0024 -0.7615 8.98712 0 0 0 8.73302 0 0 11.2353 9.89785 0 0 0 0 0 0 A0A8P0PIB4 A0A8P0PIB4_CANLF Fibroblast growth factor (FGF) FGF3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083] AMNKRGRLYASESYNAECEFVER 1 10.1 0.99322 -0.28156 0 0 0 0 0 8.35579 0 0 0 0 0 0 0 4.77152 0 A0A8P0PIC0 A0A8P0PIC0_CANLF Kinesin-like protein KIF18A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] AADPGVMYLTML;AARRKRKLTSS;AKIMISNPQEKEI;DLPGVSVLMTFPQ 4 5.7 1.0018 -0.74158 0 0 0 0 0 9.44936 10.166 0 10.1335 0 0 0 0 0 8.50434 A0A8P0PIC2 A0A8P0PIC2_CANLF Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl peptidase III) DPP3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] aminopeptidase activity [GO:0004177]; dipeptidyl-peptidase activity [GO:0008239]; metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] ARFVILRVL;FVILRVLLEAGEGLVTVTPTTGAD;IYVNWLNMVRA;LAEGLTEEEYQAFL;SPTERLYAH;VIYVNWLNMVRA 6 8.6 1.0024 -1.1559 0 8.69272 4.88611 0 0 0 0 10.2816 0 0 0 9.08167 0 0 0 A0A8P0PIC4 A0A8P0PIC4_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] DTCLVLMEKGDDIN;EREFEELDAQNRWQQLYL;VGAFVGWTLL;VLMEKGDDINIKQLLLN 4 11.8 0.9861 -0.41336 0 0 0 0 0 0 0 0 13.4306 7.44501 0 9.00402 0 0 0 A0A8P0PID5 A0A8P0PID5_CANLF Rho GTPase activating protein 22 ARHGAP22 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] GTPase activator activity [GO:0005096] LKEGWLKKQ;SLQGTRVTELLPGPEDAGKH 2 4.4 0.98951 -0.21788 0 0 0 0 0 0 13.2113 0 9.79463 0 0 0 0 0 0 A0A8P0PID7 A0A8P0PID7_CANLF Synapsin-1 (Synapsin I) SYN1 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269] cell projection [GO:0042995]; Golgi apparatus [GO:0005794]; synaptic vesicle [GO:0008021] actin binding [GO:0003779]; ATP binding [GO:0005524] APYWATHHAAATAQ;IPVSDQCLQPSRA;NYLRRRLSDSNFMANLPNGYMT 3 7.4 0.99448 -0.16179 0 13.0159 0 14.4077 0 0 0 0 12.813 0 0 0 0 0 0 A0A8P0PIE3 A0A8P0PIE3_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LHFLTDWDNDGESEGHQRHHEGHN 1 7.9 0.97368 0.041303 0 0 0 0 0 7.69488 0 0 0 0 0 0 0 0 0 A0A8P0PIF2 A0A8P0PIF2_CANLF Kazal-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) serine-type endopeptidase inhibitor activity [GO:0004867] TVLAFPHYSETS 1 13.6 0.95576 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 6.37666 0 0 A0A8P0PIF4 A0A8P0PIF4_CANLF Olfactory receptor OR4C42 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HSSAQIFLALRLPF 1 4.6 0.93655 0.060901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4992 A0A8P0PIF7 A0A8P0PIF7_CANLF Reverse transcriptase Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] YTLLYLKDAFFS 1 4.1 0.95275 0.05044 6.45187 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PIG0 A0A8P0PIG0_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) ITCH Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin protein ligase activity [GO:0061630] ECGLEMYFSVDK;GAMQQFNQ;HYTRTSKQIMWFWQFVKEIDNEK;ISAKLKENKKNWFGP;KRTTWDRPEPLPPGWE;LNEKPLPE;SNGRVYFVNHNT;TTWQRPTLE;VPQAPLPPGW 9 14.5 1.0039 -1.9861 0 7.08257 0 0 0 0 8.28388 0 7.5539 9.13484 0 0 0 0 9.49265 A0A8P0PIG2 A0A8P0PIG2_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2L3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] IFFYKKKKKTCFLIKVPYSFW 1 9.7 0.97356 0.047166 0 5.28888 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PIH3 A0A8P0PIH3_CANLF Sodium/hydrogen exchanger SLC9A9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of pH [GO:0006885] plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] sodium:proton antiporter activity [GO:0015385] CLSSMWPRGSTWKG;TDPVTVLAIFHEL 2 4.7 0.8541 0.15887 0 0 9.29225 0 0 7.56018 6.95931 0 0 0 8.21325 0 0 0 0 A0A8P0PII6 A0A8P0PII6_CANLF Collagen type VI alpha 1 chain COL6A1 Canis lupus familiaris (Dog) (Canis familiaris) PPGPEGSRGAPGP;VRQARPAAARDTGW 2 2.9 0.93548 0.073874 0 9.20909 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PII8 A0A8P0PII8_CANLF NACHT domain-containing protein NLRC3 Canis lupus familiaris (Dog) (Canis familiaris) LDFSNTVACTDPKKEIQ;LMGALCANQALTS;SLRRLNLQENSL;VATALSGNHGLQHINLQ 4 5.7 0.28462 0.66707 0 8.32584 0 0 0 12.6377 13.8564 0 14.3683 0 0 0 0 0 14.2117 A0A8P0PIK6 A0A8P0PIK6_CANLF Basophilic leukemia-expressed protein Canis lupus familiaris (Dog) (Canis familiaris) APAGQDAARRAGAPSPCGL;GGGGGGGA;GGGGGGGG;LQVAKVSP;NVSPAPEAPPRPGSPG;PPAPKPRKA 6 9.6 0.98431 -0.24417 0 0 0 0 0 0 0 9.73027 0 0 0 0 0 0 0 A0A8P0PIL0 A0A8P0PIL0_CANLF Dishevelled associated activator of morphosis 2 DAAM2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] AGEDNLEF;DFFEMVRNEDDLE;ELARRFDMVHIDTK;MPSELQHLPEAAKVNLAE;QRHQKELGSTED;VHIDTKSASQMFELI;VIDKLRQHENA;WQRQRKVHAGS 8 8.9 0.98702 -0.38054 10.3823 0 11.7463 0 0 0 6.59468 0 8.58763 0 0 0 9.26101 0 0 A0A8P0PIM0 A0A8P0PIM0_CANLF Ribosomal protein L10e/L16 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] HPAWCYQYCENKLY 1 7 0.98611 -0.23536 0 0 0 0 0 8.67101 0 0 0 0 0 0 0 0 0 A0A8P0PIN6 A0A8P0PIN6_CANLF Cell division cycle associated 4 CDCA4 Canis lupus familiaris (Dog) (Canis familiaris) LDQIFETLESKTPGSVEELFSDV;PQSSLWEVDSSRENR 2 15.7 0.94363 0.10053 0 9.51331 0 0 0 0 0 0 0 0 0 0 7.61139 0 0 A0A8P0PIN8 A0A8P0PIN8_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109] calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] AKPAEREQLREE;EEQLLQEREEQLRRRNV;EEQRRDSKWQWQ;EQELRGEQGRREQL;EQRLEQELGREQELRHEQELRREEQ;LQDPRQKEDQ;LQREEQVRRLEAEE;PHDPETVDLI;REQLRREEQRLEQQQRREQQLA;RNEQRLEQELRREQE;RNEQRLEQELRREQEERREQELRRE 11 17.9 0.97886 0.046227 0 0 0 9.51487 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PIQ7 A0A8P0PIQ7_CANLF Protein phosphatase 4 regulatory subunit 4 PPP4R4 Canis lupus familiaris (Dog) (Canis familiaris) LPFLMRQNPAETLRRVL;QENKLSSLPDL 2 3.4 0.98947 -0.20274 0 0 0 0 0 0 0 0 0 0 0 0 8.78918 0 0 A0A8P0PIQ8 A0A8P0PIQ8_CANLF Potassium channel tetramerisation-type BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] LVDRDPYFGPALNYLSSGSG 1 13.4 0.9493 0.05015 0 0 0 0 0 0 0 9.64131 0 0 0 0 0 0 0 A0A8P0PIS0 A0A8P0PIS0_CANLF Popeye domain containing 2 POPDC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FSRRQYLLDSN 1 2.9 0.98345 0.035491 8.36168 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PIS1 A0A8P0PIS1_CANLF Pre-mRNA processing factor 40 homolog B PRPF40B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" EAAQPVEQGF;KAKKPKKKTKK;KKPKKKTKKRRHKSV;LSWSNREKAKQAFKELLR;RYRRAEQTFGELEVWA;SEAAQPVEQGFLQ;SEDCDMSE;VAPDGRIYYYNADDKQSVWEK 8 10 1.0045 -1.0517 0 0 7.76487 0 4.55937 0 8.68857 10.4549 0 0 0 8.57603 8.52415 0 0 A0A8P0PIS2 A0A8P0PIS2_CANLF Uncharacterized protein C4H10orf105 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CDDNQDCDCP;GCDDNQDCDC;PGCDDNQDCDCPES 3 11.4 1.0021 -1.2765 0 0 0 0 8.01229 0 0 0 0 0 0 0 0 0 0 A0A8P0PIT0 A0A8P0PIT0_CANLF CD5 molecule like CD5L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PSEVWEKNNCTHDEDMWVEC;SSRVRLVG;SSRVRLVGG 3 8.8 0.98764 -0.48609 0 8.99311 8.88478 0 8.82362 0 9.02777 10.4258 8.8708 8.60995 9.19869 8.73285 9.84134 9.42141 9.33152 A0A8P0PIT5 A0A8P0PIT5_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKE Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] membrane [GO:0016020] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] GQEKYIPQVAVLP;IWCQKTVHDECMKNSLKNEKCDFGE;KLANPFRIGQ;LVQECKDLNKKIELE 4 12 0.98696 -0.40711 0 0 8.22997 9.05596 0 0 0 9.15866 0 10.0172 0 0 7.98145 8.11827 0 A0A8P0PIV7 A0A8P0PIV7_CANLF Calcium/calmodulin dependent protein kinase kinase 1 CAMKK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LHRKIKNEAV;VPDIKVHPWVTKGGEEPL 2 5.9 0.98764 -0.50431 0 0 10.4525 0 10.7841 0 0 0 11.9868 0 0 0 0 0 0 A0A8P0PIX0 A0A8P0PIX0_CANLF Family with sequence similarity 131 member B FAM131B Canis lupus familiaris (Dog) (Canis familiaris) DWAPGVVGVDLARGP;SEATLMAWSSMDGEDMS 2 9.4 0.98809 -0.34718 0 0 0 0 0 0 0 0 12.6875 0 0 0 0 0 0 A0A8P0PIY3 A0A8P0PIY3_CANLF Uncharacterized protein FAM174C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEGAGGLGRPAGWPDP;EGAEGAGGLGRPAGW;RVLPPPPLLPLLLLLSALLC;VLPPPPLLPLLLLLS 4 13.4 0.98745 -0.40459 0 0 0 0 0 0 0 0 0 0 0 4.69811 0 0 4.18943 A0A8P0PIZ6 A0A8P0PIZ6_CANLF Tubulin alpha-1A chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] LELSIYPPPPG;THTTLEHSDC;VISAEKAYHEQLSV 3 12 0.97972 0.035491 0 0 0 0 0 0 6.53107 0 0 0 0 0 0 0 0 A0A8P0PJ01 A0A8P0PJ01_CANLF Keratin-associated protein 21-1-like LOC111093544 Canis lupus familiaris (Dog) (Canis familiaris) CGRGSSYGCG;GSGYGCGCGYGSGYGCGCG;GYGYGCGP;MCCNYGNSCGYGCGCGYGYGCG;NSCGYGCGCGYGYGCGP;SCGYGCGC 6 55.9 1.0032 -1.503 0 0 4.46884 0 0 8.82031 0 10.9603 0 5.70318 0 4.20359 0 0 0 A0A8P0PJ05 A0A8P0PJ05_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) PJA1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; transferase activity [GO:0016740] FGADDSEEEG;QEMCCPICCSE;TDDDDDMP 3 5 1.0038 -1.6804 0 0 5.35632 0 0 0 0 0 0 0 0 0 5.34937 5.9625 0 A0A8P0PJ12 A0A8P0PJ12_CANLF KRAB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] NLMNVLNVG 1 3.9 1.0047 -0.80421 0 0 0 0 7.17163 0 0 0 0 0 0 0 0 0 0 A0A8P0PJ17 A0A8P0PJ17_CANLF Transforming acidic coiled-coil containing protein 3 TACC3 Canis lupus familiaris (Dog) (Canis familiaris) mitotic spindle organization [GO:0007052] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EESVRSYFL;EGPFADLPGKAPA;EVIEGYHTNEE;GATWPPGTQPTEACAE;LVELDFLGAP;MPESLENQV;PGDVRAVSE;RPIRLEFD;SLKKCVEDYIVR;TVEQKVGSWTHSTWGWQ;VEQKVGSWTHST;WQGPGAEAVG 12 15 1.0036 -2.3932 10.475 0 12.0312 8.57084 0 8.75549 0 11.5397 12.6049 0 0 0 0 9.03389 9.82618 A0A8P0PJ19 A0A8P0PJ19_CANLF Coiled-coil domain containing 191 CCDC191 Canis lupus familiaris (Dog) (Canis familiaris) ADQFYCQILLRRV;GGVPAGPP;PVASPGTNHRGNDSQ;QKKSVFLEAQ 4 5.4 1.0018 -1.2606 11.9212 0 0 0 0 0 0 9.16365 0 0 8.20848 0 7.14954 0 8.36378 A0A8P0PJ21 A0A8P0PJ21_CANLF Inositol polyphosphate-5-phosphatase K INPP5K Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856] phosphatase activity [GO:0016791] ENDMLISYSLTPD;IQPSSFLAEDL;VSYVWVGDNQ 3 8.2 1.0028 -0.7381 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.7777 A0A8P0PJ23 A0A8P0PJ23_CANLF 40S ribosomal protein S24 RPS24 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] VGAGKKVLFI;VGAGKKVLFIK 2 7.6 0.99293 -0.2819 0 0 0 0 0 0 0 0 0 0 4.70901 0 0 0 0 A0A8P0PJ33 A0A8P0PJ33_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KSALFKGCEENW 1 14.6 0.95311 0.05044 0 10.3882 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJ35 A0A8P0PJ35_CANLF Bardet-Biedl syndrome 2 protein homolog BBS2 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515] BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737] EDVLQAESSSPLN;SNLIRSLLVRAE 2 3.4 0.93914 0.0597 0 0 0 0 0 0 0 0 0 0 0 0 0 7.46638 0 A0A8P0PJ37 A0A8P0PJ37_CANLF ATP synthase subunit LOC102154486 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] TDVWMWFYVGEIIGK 1 14.6 0.95148 0.053901 0 0 0 0 0 0 0 0 0 8.32989 0 0 0 0 0 A0A8P0PJ39 A0A8P0PJ39_CANLF Phospholipid phosphatase 4 PLPP4 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid metabolic process [GO:0006644] membrane [GO:0016020] ELPRKIKKKKKK;ELPRKIKKKKKKKGV;FSGELPRKIKKKKKKK;GELPRKIKKKKKK;KAKPGRVFSGELPRKIKKKKK;LPRKIKKKKKKKGVGVKNF;RKIKKKKKKKG;SGELPRKIKKKKKK;TNTIKLIVGR;VIGLIFAYICYRQHYPPLA 10 10.9 0.98879 0.019291 6.64818 0 5.49525 0 8.6436 7.03232 12.2021 0 0 0 0 0 5.05255 4.05788 8.20335 A0A8P0PJ43 A0A8P0PJ43_CANLF G-protein coupled receptors family 1 profile domain-containing protein LOC484861 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MATTYTVFTPFLSPIIFSLRNKELK;RHLLPVFFLIYLLMY 2 12.7 0.95236 0.053874 0 0 0 0 0 0 0 0 0 4.67976 0 0 0 0 0 A0A8P0PJ50 A0A8P0PJ50_CANLF Translin-associated protein X (Translin-associated factor X) TSNAX Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] QELDARHDK 1 3.1 1.0047 -0.80421 9.25567 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJ55 A0A8P0PJ55_CANLF Chromatin assembly factor 1 subunit B CHAF1B Canis lupus familiaris (Dog) (Canis familiaris) DNA replication-dependent chromatin assembly [GO:0006335] nucleus [GO:0005634] AEGTPTSKVQDPSSPCTPP;DEAQLNKENWTVV 2 6.1 0.99509 -0.082287 0 0 0 0 0 8.32805 0 0 0 0 8.84687 0 0 0 0 A0A8P0PJ62 A0A8P0PJ62_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLAVLTNPSVIPENPN 1 15.7 0.95597 0.049233 0 0 0 0 0 0 0 0 0 0 0 8.16842 0 0 0 A0A8P0PJ72 A0A8P0PJ72_CANLF Annexin A2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] QRRAKNELASA 1 6.7 0.98905 -0.19891 0 0 0 0 0 0 0 10.4737 0 0 0 0 0 0 0 A0A8P0PJ78 A0A8P0PJ78_CANLF Protein kinase C (EC 2.7.11.13) PRKCA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; zinc ion binding [GO:0008270] EGFSYVNPQFVHPILQ;LMYHIQQVGKFKEPQAVFYAAEISI;LVIANIDQSD;TTRTFCGTPDYIAPEI;VTDEKLHVTVRDA 5 12.8 1.0021 -0.99909 0 0 3.18788 0 0 0 8.66213 0 0 0 0 0 8.83618 0 12.0477 A0A8P0PJ90 A0A8P0PJ90_CANLF Guanylate binding protein family member 6 GBP6 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087] GTP binding [GO:0005525]; GTPase activity [GO:0003924] NAVTTLAQLENSEA 1 2.2 0.94207 0.061101 0 0 0 5.58135 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJ93 A0A8P0PJ93_CANLF Torsin-1A-interacting protein 1 TOR1AIP1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637] ATPase activator activity [GO:0001671] AEEMNTRRATRLQEQQQQQQQQ;DSLDSADQTTILSSQYPESWQSSQ;QEFQNQMRQLMNKYQGQDEKLWRRS;QSSAYPKKTQEWFEPTTRIRTTTQT 4 15.8 0.85691 0.16035 9.0802 0 0 0 0 0 0 0 0 0 0 0 9.53607 0 10.2517 A0A8P0PJ98 A0A8P0PJ98_CANLF C2H2-type domain-containing protein E4F1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EPMETSPVIHLVTDAKG;EVIVAAEAEPG;PRPFTCAQCGKAF;QEVHVHERRFRCGDCGKLYKT;VIVAAEAEPGD 5 8.7 0.98795 -0.22698 0 0 0 8.68703 0 9.26957 0 10.3407 15.2127 0 0 0 0 0 0 A0A8P0PJB5 A0A8P0PJB5_CANLF WIZ zinc finger WIZ Canis lupus familiaris (Dog) (Canis familiaris) APGLGSEENTMVAMDL;DLSAAAAAGIFWASDVEPSPLNL;GVTEWCVNGSPIETLSEWIKHR;ILKRRTQSRPG;MDLGSPPL;VGAYRSYIQ;VLHGLIRR 7 8.9 0.95762 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.22716 A0A8P0PJD1 A0A8P0PJD1_CANLF "ATP synthase subunit f, mitochondrial (ATP synthase membrane subunit f)" Canis lupus familiaris (Dog) (Canis familiaris) ATP biosynthetic process [GO:0006754]; monoatomic ion transport [GO:0006811] "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" THRHVPLRRPILKLQVPL;THRHVPLRRPILKLQVPLQ;VPLQDTQMPCPLSH 3 18.2 0.99171 -0.18266 5.93322 0 0 0 0 0 0 0 0 0 5.46682 0 0 0 0 A0A8P0PJD9 A0A8P0PJD9_CANLF C-X-C motif chemokine LOC119874472 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009]; growth factor activity [GO:0008083] AARLLLLLLLLLGPA;AARLLLLLLLLLGPAG;APRAPRPLGAARLLLLLLLLL;LLLLLLLL;LLLLLLLLL;RLLLLLLL;RLLLLLLLL;RLLLLLLLLLGPAG 8 20.2 0.85938 0.16388 0 0 0 0 0 0 0 0 6.2256 0 0 0 0 3.82955 0 A0A8P0PJF2 A0A8P0PJF2_CANLF UBA-like domain-containing protein UBALD2 Canis lupus familiaris (Dog) (Canis familiaris) AGAGPGHS;PLFVVSAAAGAGPGHSP;TALSTFFQE 3 9.6 1.0021 -1.3074 0 0 0 0 8.28012 0 0 0 0 0 0 0 0 9.50249 9.24424 A0A8P0PJF3 A0A8P0PJF3_CANLF Ribosomal protein L15 RPL15 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic ribosome [GO:0022626]; ribosomal subunit [GO:0044391] structural constituent of ribosome [GO:0003735] VGEDSTYKFFEVILID 1 8 0.95486 0.049233 0 0 0 0 0 0 0 0 0 0 0 6.71081 0 0 0 A0A8P0PJF4 A0A8P0PJF4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KERMQCLMPEVVPSDSLKDNAY 1 14.9 0.97604 0.048004 0 0 0 0 0 0 0 0 11.4344 0 0 0 0 0 0 A0A8P0PJG3 A0A8P0PJG3_CANLF Uncharacterized protein RXYLT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGACAGP;GGGAWAGP;IFKKKKKK;WNPWEGDEKNEQQHR 4 16.2 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 5.56602 0 A0A8P0PJG8 A0A8P0PJG8_CANLF U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) SNRPC Canis lupus familiaris (Dog) (Canis familiaris) mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004] mRNA binding [GO:0003729]; U1 snRNA binding [GO:0030619]; zinc ion binding [GO:0008270] CDYCDTYL;SEMSNIPKFYCDYCD 2 10.4 0.95148 0.053889 0 0 0 0 0 0 0 0 0 0 5.99313 0 0 0 0 A0A8P0PJH3 A0A8P0PJH3_CANLF Zinc finger protein 319 ZNF319 Canis lupus familiaris (Dog) (Canis familiaris) AATAATSLPPAPPPAAVASATE;TDLLEHQCVQAEQKPFVCGV 2 7.2 0.85657 0.18473 0 0 0 6.13196 0 0 0 0 0 0 0 7.20095 0 0 0 A0A8P0PJJ1 A0A8P0PJJ1_CANLF BHLH domain-containing protein MYCN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] AGASGAGAAASAGAPA;CFYPDEDDFYFGGPDS;DDEDDEEEDEEEEIDV;DTLSDSDDEDDEEEDEEE;ECVDPAVVFPFPVN;VILKKATEYV;VVFPFPVNKREPAPAAPAG 7 19.2 0.96145 0.049233 0 0 0 6.81762 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJK1 A0A8P0PJK1_CANLF TGF-beta family profile domain-containing protein INHBC Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083]; hormone activity [GO:0005179] ALQRLHGPPQGM;DINQTRLDFHF;LFLAPATVAIPR;TAGGGSCC 4 12.3 1.0023 -1.4437 0 0 0 8.74682 0 0 0 0 10.1411 6.01134 0 0 0 0 7.03463 A0A8P0PJK8 A0A8P0PJK8_CANLF Phosphoinositide-3-kinase regulatory subunit 6 PIK3R6 Canis lupus familiaris (Dog) (Canis familiaris) "phosphatidylinositol 3-kinase complex, class IB [GO:0005944]" 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935] KHGTLGASTLGL;VIIPLLHT 2 2.5 0.9524 0.05044 6.49956 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJN3 A0A8P0PJN3_CANLF Nucleolar protein 16 LOC100683946 Canis lupus familiaris (Dog) (Canis familiaris) FYRRFYPAEWQTFIESL 1 14 0.97692 0.046227 0 0 0 0 6.62963 0 0 0 0 0 0 0 0 0 0 A0A8P0PJN9 A0A8P0PJN9_CANLF Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) EIF2B3 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] translation initiation factor activity [GO:0003743] EEGSNIQGSVICNNAVIEKGVD;GVDSLIGPDTQ;ICNNAVIEKGVDI;KGQDDLEQVPGQKGK 4 11.1 0.9876 -0.48253 0 0 0 0 0 0 0 9.95258 0 0 0 0 10.831 7.21878 0 A0A8P0PJQ1 A0A8P0PJQ1_CANLF "MYCL proto-onco, bHLH transcription factor" MYCL Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] HYFYDYDCGED;QHYFYDYDCGEDFYRST;RMATEKRQLRCRQQQ 3 8.8 0.99241 -0.16564 0 9.32236 0 0 0 0 3.9442 0 0 0 0 0 0 0 7.97137 A0A8P0PJQ2 A0A8P0PJQ2_CANLF BAALC binder of MAP3K1 and KLF4 BAALC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] CHPFFQQQK 1 6.1 1.0036 -0.80421 8.24963 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJR4 A0A8P0PJR4_CANLF "Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase)" VARS2 Canis lupus familiaris (Dog) (Canis familiaris) valyl-tRNA aminoacylation [GO:0006438] mitochondrion [GO:0005739] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832] CIPPPNVTGSL;EDCWVVGRTETE;FVPQPAEELSPSSPT;PGGGQGAG;RAFLARELPL 5 5.3 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 8.87814 0 0 0 0 A0A8P0PJR7 A0A8P0PJR7_CANLF RRAD and GEM like GTPase 1 REM1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] ILVGNKADLARCREVSVEGEP 1 8.4 0.95067 0.049623 0 0 0 0 0 0 0 0 0 0 0 0 9.06913 0 0 A0A8P0PJS0 A0A8P0PJS0_CANLF diphthine methyl ester synthase (EC 2.1.1.314) DPH5 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; protein histidyl modification to diphthamide [GO:0017183] diphthine synthase activity [GO:0004164] DISDVAFLVVGDP 1 4.6 0.98739 -0.23439 0 0 9.90087 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PJS4 A0A8P0PJS4_CANLF Corticotropin-releasing factor receptor 1 CRHR1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] EVRMPGPQ;GRRPQLRLVKALLLLGL;RCLRNIIHW;YTDYIYQGPMILVLLINFI 4 11.3 1.0044 -1.1044 0 0 0 0 0 0 0 0 9.19148 0 0 0 0 0 0 A0A8P0PJS8 A0A8P0PJS8_CANLF J domain-containing protein LOC102156933 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EFLSKLQD;QQLVKMFQWGWLE 2 3.2 1.0032 -1.0283 0 8.60133 0 0 0 0 0 7.43821 0 0 0 0 0 0 0 A0A8P0PJT3 A0A8P0PJT3_CANLF Actin-related protein 2 (Actin-like protein 2) ACTR2 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995] actin binding [GO:0003779] ERELKQLYLERVLK;KHMVFLGGA 2 6.8 1.0037 -1.0719 0 9.57924 0 0 0 0 0 0 13.6401 0 0 0 0 0 0 A0A8P0PJT4 A0A8P0PJT4_CANLF "RAB24, member RAS onco family" RAB24 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LRHHHSPG 1 3.1 0.98901 -0.26134 0 0 0 0 7.86227 0 0 0 0 0 0 0 0 0 7.804 A0A8P0PJU2 A0A8P0PJU2_CANLF Solute carrier family 7 member 8 SLC7A8 Canis lupus familiaris (Dog) (Canis familiaris) HTPLVGAGCSPAAPA;VGAGCSPA 2 11.5 0.99045 -0.21203 0 0 10.0031 0 0 0 0 10.5528 0 0 0 0 0 0 0 A0A8P0PJU4 A0A8P0PJU4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ETDVEHLIYTAERERII;TDVEHLIYT 2 3.3 1.0028 -0.75799 0 0 0 0 7.42828 0 0 0 0 7.63851 0 0 0 0 0 A0A8P0PJV0 A0A8P0PJV0_CANLF AP complex subunit sigma AP3S1 Canis lupus familiaris (Dog) (Canis familiaris) Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886] AP-3 adaptor complex [GO:0030123]; cytoplasmic vesicle membrane [GO:0030659] ESELGILD;NHGKPRLSKF 2 11.2 1.0032 -1.7158 0 0 6.19466 0 0 0 0 8.648 0 0 0 0 0 0 0 A0A8P0PJW6 A0A8P0PJW6_CANLF Succinate dehydrogenase assembly factor 3 (SDH assembly factor 3) (SDHAF3) DLX6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial respiratory chain complex II assembly [GO:0034553] mitochondrial matrix [GO:0005759] LLHRALPP;LYRRILLLHRALPPDLKTLG 2 16 1.0033 -1.0562 0 0 10.4497 0 9.94999 0 0 0 0 10.086 10.572 10.4876 11.3654 11.4318 11.4222 A0A8P0PJX6 A0A8P0PJX6_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" APSADAPVF;WYDNVFSYSNRAVD 2 10 1.0032 -1.1173 0 0 0 0 0 0 0 0 9.78016 0 0 0 0 0 0 A0A8P0PJX7 A0A8P0PJX7_CANLF RING-type domain-containing protein RNF149 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HIFHRICIDPWLLDHRTCPMCKL;ITMMIISLAWLIFYYIQR 2 10.9 0.98725 -0.22809 9.04647 0 9.63666 0 0 9.22272 0 0 0 0 0 0 0 6.50894 0 A0A8P0PJY8 A0A8P0PJY8_CANLF tRNA-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) tRNA binding [GO:0000049] GAEADQIIEYLKQQVA 1 5.9 0.96054 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 6.15605 0 0 A0A8P0PK21 A0A8P0PK21_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAQTNDEADYYCQVWESSA;KPGQAPLLIIYN;TGSVASYVLTQSPSVSV 3 32.9 0.98666 -0.41904 0 0 0 0 0 0 10.814 0 0 0 0 8.15487 0 0 0 A0A8P0PK34 A0A8P0PK34_CANLF DENN domain-containing protein 11 (Protein LCHN) DENND11 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] EDLFVLFFLEQNNRI;KFALLRKRILI;PRLAMVERGAAAPL 3 8.5 0.98807 -0.26022 0 0 0 0 0 0 0 11.7647 0 0 0 0 0 0 0 A0A8P0PK39 A0A8P0PK39_CANLF Caveolae associated protein 2 CAVIN2 Canis lupus familiaris (Dog) (Canis familiaris) caveola [GO:0005901] AKGLSQTSLASAPAEG;EAMEESRAEKMKR;EGAERSDEEPEQ;LEGDADLTAREDEEEE 4 13 0.99098 -0.00029761 0 0 9.68161 7.72363 8.06053 7.91582 0 8.26012 0 9.51973 9.61366 9.47654 9.66894 9.65944 9.30058 A0A8P0PK46 A0A8P0PK46_CANLF Large ribosomal subunit protein uL11 (60S ribosomal protein L12) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] TGGTKART;VATHGTGG;VGCNVDGH 3 11.5 1.0029 -2.4747 0 0 9.81868 0 0 0 9.18948 0 7.52701 0 0 0 9.65694 0 0 A0A8P0PK47 A0A8P0PK47_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR75 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AADTRLEPYYG;ASVPGAALLAAL;FTLAALGA;LRMVLGRQPSRPAS;SSTAADTRLEPYYGV 5 9.3 0.98873 -0.3181 10.8954 0 0 7.45204 0 9.74833 0 0 0 0 0 0 0 0 0 A0A8P0PK50 A0A8P0PK50_CANLF Coiled-coil domain containing 27 CCDC27 Canis lupus familiaris (Dog) (Canis familiaris) AEVGGLGGPCPLQ;EEEEEEEGGVEQEEEKE;FSKSACEFNYL;RQVDFQESQLQQVNTENNTLQK;VDKEGKGP 5 9.9 1.0021 -0.65221 0 0 0 0 8.74389 0 0 0 10.415 7.02989 0 9.34063 0 0 0 A0A8P0PK52 A0A8P0PK52_CANLF UDP glycosyltransferase 8 UGT8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] EIHKDQPG;KIIIVPPIM;SGSRKGRKGGAASGSDSSDKKAQG 3 6.2 1.0029 -2.198 0 0 7.45327 0 0 9.5257 0 9.33923 0 0 0 0 0 0 0 A0A8P0PK60 A0A8P0PK60_CANLF Natural resistance-associated macrophage protein 1 (Solute carrier family 11 member 1) SLC11A1 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] metal ion transmembrane transporter activity [GO:0046873] FPRNNLTVEVDIYQGG;GVMLGCVFGPAALYIW;ISHPPSSEPQQEPL 3 8.9 0.98935 -0.53177 0 0 0 0 0 7.5656 0 0 0 0 0 0 0 0 0 A0A8P0PK64 A0A8P0PK64_CANLF Aminotransferase class V domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) L-serine biosynthetic process [GO:0006564] O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648] YVCPVESKNRS 1 9.3 0.98326 0.035491 0 0 0 0 0 0 0 11.2825 0 11.0953 8.4168 0 9.07478 4.53804 3.73042 A0A8P0PK69 A0A8P0PK69_CANLF PLD phosphodiesterase domain-containing protein PLD4 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] NHSKFVVTE;VGSGGGSL 2 2.9 1.002 -1.4178 0 0 0 0 0 0 0 10.3067 0 0 0 0 0 0 0 A0A8P0PK80 A0A8P0PK80_CANLF Chromosome 7 C1orf112 homolog FIRRM C7H1orf112 Canis lupus familiaris (Dog) (Canis familiaris) DTKNKVISFLEKTGFVEETAA;FVQVVLDSKLELPS;VISFLEKTGFVE;VLDSKLELPSE;YSLQKQLMELLDMVC 5 6 1.0019 -0.74291 5.3844 0 0 0 0 0 7.39069 0 10.8164 0 0 0 0 0 0 A0A8P0PK94 A0A8P0PK94_CANLF EP300 interacting inhibitor of differentiation 1 EID1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DFESEDEGEEFDDWEDDYDYPEEE;EDEGEEFDDWEDDYDYPEEEQ;EEFDDWEDDYDYPEEEQ;FESEDEGEEFDDWEDDYDYPEEEQ;MPGEGDLPQMEVGGG;PDFESEDEGEEFDDWEDD;SEDEGEEFDDWEDDYDYPE 7 23.3 0.99396 -0.1318 0 14.3382 0 13.3201 13.4837 0 7.01167 0 0 0 13.9481 13.9719 7.43121 14.5993 14.6207 A0A8P0PKA5 A0A8P0PKA5_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEHHLRDY;GGIKEDTEEHHLRDYFKQYGKIEVI 2 23.4 0.99203 -0.29197 0 0 0 0 0 0 0 12.094 0 0 0 0 0 0 0 A0A8P0PKA8 A0A8P0PKA8_CANLF Membrane spanning 4-domains A3 LOC102155828 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVAQIMIGVK;IFYGIIGFLLL;TLSTFISIAGIC 3 15.8 0.98642 -0.41993 12.0931 0 0 0 0 0 0 0 10.1411 0 0 0 9.76731 0 10.628 A0A8P0PKB2 A0A8P0PKB2_CANLF Nucleolin NCL Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] DNA binding [GO:0003677]; RNA binding [GO:0003723] AAAPASDEEEDDE;AAAPASDEEEDDEEDDDE;AAAPASDEEEDDEEDDDEDDDEE;AAPASDEEEDDEEDDDEDDDE;DDDEDDDEEDEDEDEDDSE;DDEDDDEEDEDEDEDDS;DDSEEEDEEDEDEDEDEFE;DEDEDDSEEEAMET;DEDEEDDDEEEEDEDDDEE;DEEDEDEDEDDSEEEAME;DSDEEEDDDSEEEDEEDE;DSEDEEMSEDEDDDSSGE;EDDDEDDDEEDEDEDEDDSE;EDDEDEEDDDEEEEDEDDDEE;EDEDEDEDDSEEEAMET;EDSEDEEMSEDEDDDSS;EEDDDSEEEDEED;EEDDDSEEEDEEDEDEDED;EEDEEDEDEDEDEF;EEDEEEEEEEEEEEPVKEAPG;EEEDDDSEEEDEEDE;IVTDRETGSSKGF;KGIAYIEFKTEADA;PASDEEEDDEEDDDE;PASDEEEDDEEDDDEDDDEEDED;PPPKEVEEDSEDEEMSEDEDDDSS;SDEEEDDEEDDDEDDD;SEEEDEEDEDEDEDEFE;TAEDEDEEEDDED;TAEDEDEEEDDEDEE 30 23.7 0.80645 0.21116 6.18218 4.11478 0 0 0 0 0 0 5.5509 0 0 0 0 0 6.05595 A0A8P0PKB7 A0A8P0PKB7_CANLF protein kinase C (EC 2.7.11.13) PRKCZ Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] DTTSTFCGTPNYIAPE;FFRSIDWDLLEKKQALPP;LCDEVREMCSL;LRGEEYGFSVDWWAL;NKDPKERLGCRPQ;VLLVRLKKNDQMYA 6 15.5 1.0023 -0.6675 10.1486 0 0 0 0 0 8.19918 0 0 0 0 0 6.42122 0 0 A0A8P0PKC3 A0A8P0PKC3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) APTLPLPTPIIAEHGH;LDQKETFKHVEQHPRH;MKPTKPMEQDKPMTIEPNQFSLSLG;NEAGFLTRYPE;VSSADFRQR 5 13.4 1.0015 -0.91474 10.0935 9.77923 0 6.66135 7.22612 0 0 0 0 10.8317 0 0 11.1649 0 0 A0A8P0PKC6 A0A8P0PKC6_CANLF Glucosidase 2 subunit beta PRKCSH Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CDCCDGTDEY;CDCCDGTDEYNSGIVCENT;CDCKDGSDEPGTAA;DGSATILFDQVN;GVCDCCDG;GVCDCCDGTDE;GVCDCCDGTDEYN;GVCDCCDGTDEYNSG;LLLLLLLP;LLLLLLPL;TAACPNGSFHCSNTGYKP;TILFDQVNDDYCDC;VEEEEEEEEEEEPEEEEEEEE;YRLCPFKLVSQK 14 20.5 1.003 -2.4585 0 0 8.5672 6.2503 12.3066 0 15.4207 10.1226 6.95536 0 0 0 4.67886 10.6304 0 A0A8P0PKC9 A0A8P0PKC9_CANLF Chromosome 1 C19orf47 homolog C1H19orf47 Canis lupus familiaris (Dog) (Canis familiaris) GATPEMDEDLAWDSDN;MATSEWIQ;SEWIQFFKEAGIPPGPA 3 10.2 1.0024 -0.71781 0 0 0 0 0 0 0 9.34352 0 0 0 0 0 9.29549 0 A0A8P0PKD9 A0A8P0PKD9_CANLF NHERF family PDZ scaffold protein 4 NHERF4 Canis lupus familiaris (Dog) (Canis familiaris) TPALSPKIPQLFM 1 2.7 0.94186 0.059873 0 0 0 0 0 6.40337 0 0 0 0 0 0 0 0 0 A0A8P0PKE3 A0A8P0PKE3_CANLF Receptor activity-modifying protein 3 RAMP3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] plasma membrane [GO:0005886] coreceptor activity [GO:0015026] EDPPDEVL;LIPLIAVPVLLTV;VGPLPIPD;VLIPLIAVPVLLTVAMA 4 10.5 1.003 -1.1044 0 0 0 0 0 7.47005 0 0 0 0 0 0 0 0 0 A0A8P0PKE4 A0A8P0PKE4_CANLF Tetratricopeptide repeat protein 29 TTC29 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] APLVILILLVILILSIL;ARVRSLSWLQRP;DDDLSLGRAYEAI;EYKQAIRIL;FVSFLMAPLVILILLVILIL;GLLFEEEGQLLE;LDDDLSLGRAYEA;LVILILLVILILSIL;LVILILLVILILSILYYI;LVILILLVILILSILYYIS;LVILILLVILILSILYYISI;PLVILILLVIL 12 15 1.0018 -0.74437 6.09187 0 0 6.49665 0 2.72415 10.2116 0 0 0 5.2267 6.51735 0 10.7067 5.72838 A0A8P0PKE7 A0A8P0PKE7_CANLF EARP complex and GARP complex interacting protein 1 EIPR1 Canis lupus familiaris (Dog) (Canis familiaris) GVLATCYNKPGQ;HQVGEIWHI 2 8.6 0.98805 -0.50541 0 0 9.89809 0 0 0 0 7.20016 0 0 0 0 0 0 0 A0A8P0PKF3 A0A8P0PKF3_CANLF Receptor activity-modifying protein 3 RAMP3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] plasma membrane [GO:0005886] coreceptor activity [GO:0015026] ARRRPQLRLLLLLLL;EDPPDEVL;LIPLIAVPVLLTV;LLLLCGGC;LLLLLLLCGGCPRVGGCN;LLLLLLLL;RLLLLLLL;RLLLLLLLL;RRRPQLRLLLLLL;RRRPQLRLLLLLLLL;VLIPLIAVPVLLTVAMA 11 33.3 1.0034 -2.2777 0 10.0142 0 8.92582 5.47119 0 10.7928 9.9039 9.22819 0 0 3.63332 0 0 0 A0A8P0PKF6 A0A8P0PKF6_CANLF Family with sequence similarity 149 member B1 FAM149B1 Canis lupus familiaris (Dog) (Canis familiaris) EAALSQERDST 1 2 0.98443 -0.25429 0 0 0 0 0 0 0 0 7.45845 0 0 0 0 0 0 A0A8P0PKG2 A0A8P0PKG2_CANLF Helicase ATP-binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] DTSGCVISCWYP;EAGVGRGANQVIPGDT 2 6.3 0.99331 -0.17394 0 0 7.64335 0 0 0 0 0 0 9.88806 0 0 0 0 7.87338 A0A8P0PKG5 A0A8P0PKG5_CANLF Signal induced proliferation associated 1 like 3 SIPA1L3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] GGGGGGGE;GGGGGGGG;IVRAHNPCTD;KFNLISLTSKKKEKTK;PGGGGGGG;PSTVPTTGSNGFPEKKSTISAS 6 3.6 0.99324 -0.16093 0 8.69471 10.0164 7.33575 0 8.24422 0 0 0 0 0 0 0 0 0 A0A8P0PKJ6 A0A8P0PKJ6_CANLF Cysteine protease (EC 3.4.22.-) ATG4D Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; protein transport [GO:0015031]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786] EQERRHRQIVSWFADHP;FSKISSVHLCGR 2 6.7 0.99087 -0.26886 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.14906 A0A8P0PKK0 A0A8P0PKK0_CANLF DNA polymerase delta subunit 2 POLD2 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] delta DNA polymerase complex [GO:0043625] DNA binding [GO:0003677] AGAEGQGRGAGGQGRPARD;SRVILAGN 2 4.2 1.0039 -1.0549 0 0 0 0 0 0 0 0 5.24028 0 8.95646 0 0 0 0 A0A8P0PKK8 A0A8P0PKK8_CANLF Amyloid beta protein binding family B member 1 APBB1 Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta binding [GO:0001540] EDETLKLVEPQ;EEEEEDLSSPQ;PFWLWAEMSTHLHSSWLPAQPPS 3 6.6 0.9913 -0.27297 0 0 0 0 0 0 8.77357 0 0 0 0 0 0 0 0 A0A8P0PKM5 A0A8P0PKM5_CANLF Cyclin dependent kinase 19 CDK19 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HYTKAIDIWAIGCIFAELLTS;LDGIHYLHANWVL;LPTLDVFAGCQIP 3 10.1 0.86 0.18487 7.5472 0 0 8.40314 0 0 0 0 0 0 0 0 11.4915 0 0 A0A8P0PKN2 A0A8P0PKN2_CANLF SPATA31 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DPEEPCLDEQ;PESQFRRK;QAAAGPNVCYHRV;QEREYYRRPNAGEHEEEVEELKV;SLPLKVLKPI;THLGRKLGQIREGQI 6 6.6 1.0033 -2.2202 0 0 0 0 0 0 0 9.31479 6.00711 0 0 0 10.145 0 0 A0A8P0PKQ2 A0A8P0PKQ2_CANLF Four-jointed box kinase 1 FJX1 Canis lupus familiaris (Dog) (Canis familiaris) VLELHRGRDAA 1 2.6 0.98477 0.035491 7.75936 0 0 0 0 0 8.32589 7.99016 0 0 0 0 0 0 0 A0A8P0PKQ3 A0A8P0PKQ3_CANLF SRR1-like domain-containing protein SRRD Canis lupus familiaris (Dog) (Canis familiaris) LNSLGLTVLSEN;NLLWSNWSLDALSQMLL 2 8.9 0.93236 0.096667 0 0 0 0 0 0 0 5.6634 0 0 0 10.2342 0 0 0 A0A8P0PKQ4 A0A8P0PKQ4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) secretory granule [GO:0030141] GARAHLGG;PGLLGCLFQDDLCSS 2 11.5 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 11.2017 0 0 0 0 0 A0A8P0PKR8 A0A8P0PKR8_CANLF Coiled-coil domain containing 9B CCDC9B Canis lupus familiaris (Dog) (Canis familiaris) ARHRDAQGDW;EGAREPQSPG;KEELENQERSQSTRKTRSEEGHSQ 3 13.4 1.0032 -0.88689 9.83812 0 0 0 0 0 0 0 0 0 0 8.42227 0 0 0 A0A8P0PKS3 A0A8P0PKS3_CANLF Heat shock protein family A (Hsp70) member 4 like HSPA4L Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662] FDPYLGGRNF;KKYGQPIQMRYM;LNCYIAVARSG;NAVEEYVYDFRDKLGTVYEKFI 4 7.2 0.99273 -0.55451 0 0 0 0 0 7.97573 0 0 0 0 0 0 0 8.45483 0 A0A8P0PKS6 A0A8P0PKS6_CANLF Metaxin 3 MTX3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] SAM complex [GO:0001401] VLHTFWVESDN 1 4.5 0.97973 0.035491 0 0 0 0 9.668 0 0 0 0 0 0 0 0 0 0 A0A8P0PKS7 A0A8P0PKS7_CANLF Solute carrier family 35 member G1 SLC35G1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ITFSTPVFTS;TASCRPAEL 2 4.1 1.0039 -1.0618 10.1289 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PKS8 A0A8P0PKS8_CANLF Coiled-coil domain containing 8 CCDC8 Canis lupus familiaris (Dog) (Canis familiaris) DNQRAEAADDQRAEAA;DVDYLLIPRE;EAADDQRAEAAD;EFRERLIQFLEE;PVSYLGSKFLGSDLES 5 10.6 1.0029 -0.73805 0 12.0703 0 0 0 0 0 0 0 7.25635 7.62154 0 0 11.943 0 A0A8P0PKT1 A0A8P0PKT1_CANLF Family with sequence similarity 200 member A FAM200A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ESIIELNLEPEEENELSQLS 1 3.6 0.96638 0.0486 0 0 0 0 5.90648 0 0 0 0 0 0 0 0 0 0 A0A8P0PKV0 A0A8P0PKV0_CANLF KN motif and ankyrin repeat domain-containing protein 2 KANK2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of actin filament polymerization [GO:0030837] mitochondrion [GO:0005739] DGEPTRQAASCQSQEVGGAGE;DLPEPLEDPV;EPVDKQNRAGYS;PAESPSSPPGVEATSL 4 6.9 1.0037 -0.8227 7.22371 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PKV5 A0A8P0PKV5_CANLF Olfactory receptor OR7A26 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVEIPHFFCELNQVIQL;FLLTVMAYDRFMAICNPLHYMVIM 2 13.3 0.98436 -0.23909 0 0 0 0 0 9.4149 0 7.25927 0 0 0 0 0 0 0 A0A8P0PKV8 A0A8P0PKV8_CANLF Tudor and KH domain containing TDRKH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] RNA binding [GO:0003723] AAIHQILTENTPVSEQLS;DMLHDVATETDVSLGSMLTEPK;RSLQLDKLVSEMTQHYENSLPEDL;SPEMSMFEIPSPDFSFHAD 4 14.8 0.98761 -0.46588 0 0 0 0 7.71905 0 0 0 0 5.50138 0 0 11.5058 0 0 A0A8P0PKW6 A0A8P0PKW6_CANLF LRRNT domain-containing protein LRRC32 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLRNNSFSLLPGSAMGGLETSLR;DLSANPGLDVV;FEALPHLAHLNLSRN;FSHPSRNASTHPLS;KMVDKEVLCQGLG;LVDNEMEMLRAGAF;SRNASTHPLSQ 7 13.7 0.98652 -0.32157 0 12.1854 0 0 0 7.41861 11.4392 0 0 11.6532 11.7868 11.7884 0 9.29297 0 A0A8P0PKX0 A0A8P0PKX0_CANLF tRNA splicing endonuclease subunit 15 TSEN15 Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" nucleus [GO:0005634] nucleic acid binding [GO:0003676] IVESDSTIVYYK;RRRRRRWRPLLGPRGRL 2 12.5 0.97605 0.046227 0 0 0 0 0 0 0 9.25382 0 0 0 0 0 0 0 A0A8P0PKX4 A0A8P0PKX4_CANLF F-box/SPRY domain-containing protein 1 (F-box only protein 45) FBXO45 Canis lupus familiaris (Dog) (Canis familiaris) AAAAAPGPAGEAMA;GAGGGGGG;GGGGGGPG 3 4 0.93218 0.060775 0 4.93367 0 0 0 0 0 0 0 0 8.96099 0 0 0 0 A0A8P0PKX5 A0A8P0PKX5_CANLF YTH domain-containing family protein YTHDF3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723] FAHYEKRQEEEEAMQK;FIIKSYSEDDIHRSI;STEHGNKRLDAAYR 3 7.7 0.99499 -0.15258 9.23967 0 0 0 0 11.5358 0 0 0 0 0 0 0 0 0 A0A8P0PKX9 A0A8P0PKX9_CANLF Fibrinogen C-terminal domain-containing protein FIBCD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] chitin binding [GO:0008061] HWLGLRRLHALTT;MKFTTRDRDSDHSENN;VSTGPAGA 3 8 1.0028 -0.78688 10.254 0 0 0 0 0 0 13.1222 0 0 0 0 0 0 0 A0A8P0PKY4 A0A8P0PKY4_CANLF Vang-like protein VANGL2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ENSTNNSTGQSRAVI;ESILQHLEFCIT;FVDPKSHKFVMRLQSET;HERRVRKRRARLV;ISVAFKLLILLL;YHKERWLAKQW 6 15.4 0.97669 0.046227 8.32134 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PKZ7 A0A8P0PKZ7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EKKKIQSSNLEMVMFVMRDRAESS;INFTDCSLSHQLKNPEQP 2 30.9 0.93717 0.089615 0 0 8.70598 0 0 0 8.07703 0 0 0 0 0 0 0 0 A0A8P0PKZ9 A0A8P0PKZ9_CANLF ATP-dependent RNA helicase (EC 3.6.4.13) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] ELVDYILQKS;ETQVGWHG;LDESFLELVDYILQKSHIAEDPDDL;SRRDHFSIERAQHEVPA 4 9.9 1.0039 -1.1044 9.44439 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PL02 A0A8P0PL02_CANLF Cholinergic receptor nicotinic beta 3 subunit CHRNB3 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] LPKVLCMKDHVDRYSF;YKSSCTMD 2 5.7 1.0021 -1.2767 0 0 0 0 5.43212 0 0 0 0 0 0 0 0 0 0 A0A8P0PL05 A0A8P0PL05_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 12 ADAMTS12 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DTPTFRQMQ;HIVVVRLILLEEEEQGLKIV;MPLGAPPTPSLGAASP;PVPPTPRSPRSPST;RSPRSPSTPPGPE;SEKMLDAVIDG;TPEPIPKATPAPIPKVTPKPT;TPTAPCNSQPCCHWAT 8 7.6 1.002 -1.2148 0 6.132 10.6243 0 7.45335 0 11.7809 0 0 5.25001 0 0 8.16717 0 7.34145 A0A8P0PL20 A0A8P0PL20_CANLF Glutamate ionotropic receptor NMDA type subunit associated protein 1 GRINA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVAHAGGPA;YPGGPQPSMPPYPGA 2 5.7 1.0044 -0.80421 8.38288 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PL27 A0A8P0PL27_CANLF "Coenzyme Q3, methyltransferase" COQ3 Canis lupus familiaris (Dog) (Canis familiaris) "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [GO:0010420]; 3-demethylubiquinol-n 3-O-methyltransferase activity [GO:0061542]" LTEPGGSLFITTINKTQ 1 12.1 0.98589 0.046227 0 0 0 0 0 0 0 0 6.01134 0 0 0 0 0 0 A0A8P0PL49 A0A8P0PL49_CANLF CD2 associated protein CD2AP Canis lupus familiaris (Dog) (Canis familiaris) GELNGKEGVFPD;GVFPDNFAI;QTKNIKKKTKKRQCKVLFEYLPQNE;SFRHFFFFFLVDYIV 4 9 1.0023 -0.66436 0 0 0 0 0 0 0 0 0 0 9.53148 0 8.77307 6.68552 10.2425 A0A8P0PL71 A0A8P0PL71_CANLF inorganic diphosphatase (EC 3.6.1.1) PPA2 Canis lupus familiaris (Dog) (Canis familiaris) phosphate-containing compound metabolic process [GO:0006796] cytoplasm [GO:0005737] inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287] GKPENQFAFNGEFKNKAF;PGYLEATLNWFRFYKVPEG;PTKRARSDEYENLFNM 3 15.2 0.98568 -0.4296 0 0 0 9.10415 0 0 11.0428 0 0 0 0 0 0 0 0 A0A8P0PL80 A0A8P0PL80_CANLF Centrosomal protein 55 CEP55 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896] cytoplasm [GO:0005737] IQYPATEHRDLLV 1 3.1 0.99308 -0.14992 0 0 12.8139 0 11.2301 0 0 0 0 11.359 0 0 12.5017 0 12.5562 A0A8P0PL81 A0A8P0PL81_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] FYILTLFTKHT;SLCLCLCLFL 2 7.2 1.0016 -0.91288 0 0 0 0 0 0 0 0 8.74393 0 0 0 0 0 0 A0A8P0PL98 A0A8P0PL98_CANLF Potassium voltage-gated channel interacting protein 1 KCNIP1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] LDEFLESCQEVRRDL 1 7.2 0.99035 -0.21307 0 0 0 9.7271 9.75414 0 0 0 0 0 0 0 0 0 10.0192 A0A8P0PLA4 A0A8P0PLA4_CANLF Olfactory receptor OR9K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FTFFIVTE;VSFVYLTP 2 5.1 0.99282 -0.18821 0 0 0 8.75014 0 8.96139 0 0 0 0 0 0 0 0 0 A0A8P0PLA5 A0A8P0PLA5_CANLF Abasic site processing protein HMCES (ES cell-specific 5hmC-binding protein) (EC 3.4.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (Peptidase HMCES) (SRAP domain-containing protein 1) HMCES Canis lupus familiaris (Dog) (Canis familiaris) protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508] lyase activity [GO:0016829]; peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697] AGIFDCWESPEGDLLY;FISPSSVQPGARCVYVP;TEKSGSIG;VNNSRNNTPKCLAP 4 16.6 0.98744 -0.35408 10.6242 0 0 0 0 0 0 0 8.31252 7.8132 0 4.90053 0 0 0 A0A8P0PLB7 A0A8P0PLB7_CANLF Small ubiquitin-related modifier 1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; PML body [GO:0016605] ACGAVGKRDGFVNPG;DVEAEDVIEVYQE 2 20.1 0.98942 -0.21905 0 0 0 0 0 0 0 0 0 0 0 0 8.08836 0 0 A0A8P0PLC1 A0A8P0PLC1_CANLF Nuclear receptor coactivator 4 NCOA4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879] transcription coactivator activity [GO:0003713] LKITYKSCISRHLE;WLYEQVDLIYQLKEETLQ 2 5.4 0.99113 -0.19494 0 0 0 0 0 12.1813 4.92756 0 0 0 0 0 0 0 0 A0A8P0PLC5 A0A8P0PLC5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MYO3B Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] cell projection [GO:0042995]; cytoplasm [GO:0005737]; myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]; protein serine/threonine kinase activity [GO:0004674] AADVRDAMSKALYGRLFSW;AFKAHETPFAS;ATNQTLVDKFEDNLRCKYFW;ESAVPIQAGYPS;FWMAPEVIA;GFENFGRNSFE;GVKLVDFGV;MSKALYGRLFSWIVNR;SENGHIQK;SLVEAFGN;VGEKNFHIFYYIYAGLY;VLCISPEELQE;VSGTDLLSSWTC 13 12.3 1.0032 -2.3331 0 0 0 0 10.2236 0 11.3254 0 8.17463 9.28478 0 0 9.82359 0 0 A0A8P0PLE1 A0A8P0PLE1_CANLF Catenin alpha-1 CTNNA1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; structural molecule activity [GO:0005198] IVDPLSFSEERFRPSLEERLES;YTLDHRSV 2 3.6 0.99402 -0.1221 0 8.67151 0 0 0 8.59178 0 0 0 0 0 8.95452 0 0 0 A0A8P0PLE5 A0A8P0PLE5_CANLF Uncharacterized protein LOC479430 Canis lupus familiaris (Dog) (Canis familiaris) KQITPPPPAL 1 3.7 0.99156 -0.27577 0 0 9.67904 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PLE9 A0A8P0PLE9_CANLF C3H1-type domain-containing protein ZC3H11A Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AADDDEDDDDQFSEEGDE;AADDDEDDDDQFSEEGDETKTP;ADDDEDDDDQFS;AERVTKVGEIHVKTLEEILL;LGNETVCTLWQ;RCFRQVCR;SPQLRSVMKVESSE;TDKAPKKVHVSKSL 8 11.2 1.0043 -2.0188 6.42475 10.9848 0 0 0 0 0 0 0 0 0 0 9.64715 0 9.38612 A0A8P0PLF0 A0A8P0PLF0_CANLF Stearoyl-CoA desaturase SCD Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" LVSLGAAGEASTTTTTP 1 4.5 0.95125 0.056639 0 0 10.5347 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PLG2 A0A8P0PLG2_CANLF Arylacetamide deacetylase like 3 AADACL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carboxylic ester hydrolase activity [GO:0052689] DVVVTDLLFGTVPVKLYQPKGL;EPLNEAAYLETSL;GSVVLAVGYRKL 3 13.4 0.99079 -0.22201 0 0 0 0 0 0 0 0 0 7.98077 0 0 0 0 7.25748 A0A8P0PLG4 A0A8P0PLG4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PVCPHSRQ 1 0.9 0.99105 -0.2101 0 0 0 0 0 10.871 0 0 0 0 0 0 0 0 0 A0A8P0PLG6 A0A8P0PLG6_CANLF "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase)" RARS1 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA aminoacylation [GO:0006420] cytoplasm [GO:0005737] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524] EENLKLKYRLKILRKSLQAERTRP;FTEFYDSCYC;GFINVHLRKDFVS;NLKLKYRLKIL;TQWSYWDW;VHFQTIFGAAQMIG 6 10.7 1.0027 -1.4906 0 0 0 4.71661 9.55445 0 0 0 6.1692 0 0 7.52176 0 0 10.0046 A0A8P0PLH4 A0A8P0PLH4_CANLF Myomesin 2 MYOM2 Canis lupus familiaris (Dog) (Canis familiaris) AGISRPSRVSEAVAALDPVDLR;GSNAWEPCNHKPIGY;GVGRPSETS;LFKCEAWTM;LKSELAYEIFD;RVLSANKHGLS;VTLCSQETAFRSV 7 5.6 1.0017 -0.91218 8.49514 11.3697 5.74486 0 0 8.51235 8.81519 9.15527 0 0 0 0 8.18319 0 0 A0A8P0PLH8 A0A8P0PLH8_CANLF isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) IARS1 Canis lupus familiaris (Dog) (Canis familiaris) isoleucyl-tRNA aminoacylation [GO:0006428] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049] RESANVTDRW;VNLNIYANGSEQGGV 2 2.2 0.9918 -0.040882 0 0 0 0 0 0 0 0 0 0 11.8858 0 0 0 0 A0A8P0PLI7 A0A8P0PLI7_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] FCHYVSLDFRGYRSKST;NRNTSETMDCRYC;SETMDCRYCSSN 3 17.6 0.99378 -0.15588 0 0 5.83071 0 7.74604 0 0 0 0 0 9.79886 0 0 0 0 A0A8P0PLJ0 A0A8P0PLJ0_CANLF Poly(ADP-ribose) polymerase family member 4 PARP4 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] HTRLFSCGIGSTANRHMLR;LTPELGFILNLNINI;PPSLAKYRALRCKIEHVEQNTEE;TANRHMLRTLSQYG;VAKYNTLEKIGAK 5 4.6 0.9953 -0.086448 0 0 0 0 0 0 0 0 0 0 0 0 8.86765 0 0 A0A8P0PLK9 A0A8P0PLK9_CANLF Canopy FGF signaling regulator 3 CNPY3 Canis lupus familiaris (Dog) (Canis familiaris) ETICKRLL 1 5.4 0.99479 -0.17368 0 0 11.9367 0 0 0 0 0 0 0 0 0 0 11.4771 0 A0A8P0PLL1 A0A8P0PLL1_CANLF Protein Wnt WNT7A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; system development [GO:0048731]; tissue development [GO:0009888]; Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] EPVRASRNKRPTF;NTCSERTEVY;YHRDEGWKWGGCSADIRYGIGFAKV 3 14 0.99241 -0.5516 0 0 0 0 0 0 10.494 0 0 6.32641 0 0 0 0 0 A0A8P0PLM0 A0A8P0PLM0_CANLF Zinc finger protein 521 ZNF521 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DGVDVEDDPTCSWPASSPSS;ETFHTVEELY;GLREHMQTHL;KKKKKKAS;KYTSLDSFQTHLKTHLDT;PDGFGGLASIFHYYV;SEVVNDLNTLQEHIRCS;SGGGGGGA 8 7.4 1.003 -2.1121 0 7.54218 11.728 8.6585 0 0 8.17587 0 0 8.38154 0 0 0 0 0 A0A8P0PLN3 A0A8P0PLN3_CANLF Casein kinase 2 subunit alpha' interacting protein CSNKA2IP Canis lupus familiaris (Dog) (Canis familiaris) DLLQSSRSLESN;VIHHKLQT;YYDQHFVSLEHSYQ 3 5.5 1.0015 -0.69579 0 0 0 0 9.5698 0 0 13.0098 9.7942 9.78945 0 0 0 0 0 A0A8P0PLN8 A0A8P0PLN8_CANLF Tectonic family member 3 TCTN3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] AASLTSLRSGNPG;DINCCCDKDC;GVGAGGFC;PQAHVSGTRFLYRCQSIKDYQ;VFSFCLPG;VLILCLLVLGVLKL;VLKVPRGMTDLQNMKFQ 7 15.6 1.0029 -2.3543 8.83662 0 0 7.15694 0 0 0 11.7163 0 0 0 0 0 0 9.73169 A0A8P0PLP3 A0A8P0PLP3_CANLF C2orf72-like C-terminal domain-containing protein C25H2orf72 Canis lupus familiaris (Dog) (Canis familiaris) FWEWSCVHRDLRDRVDQYPRWNTYR 1 6.4 0.97383 0.035538 0 0 0 0 0 6.92825 0 0 0 0 0 0 0 0 0 A0A8P0PLP5 A0A8P0PLP5_CANLF "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (Sialyltransferase St8Sia IV)" ST8SIA4 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] ISQDLHSLLPEV;LHNRGALK;QHSVEGWKINSSLVLE 3 10.7 1.0012 -0.74547 0 9.18197 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PLP8 A0A8P0PLP8_CANLF Phosphoglucomutase 2 like 1 PGM2L1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] intramolecular phosphotransferase activity [GO:0016868] TAIGQWLRWDKNP;VIQSTQPYAVQE;VVAAEMAAYLE 3 6.5 0.98316 -0.25374 9.96356 0 0 0 0 0 9.59503 0 11.5854 0 0 0 0 0 0 A0A8P0PLP9 A0A8P0PLP9_CANLF Dynein axonemal assembly factor 1 DNAAF1 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] cilium [GO:0005929] dynein complex binding [GO:0070840] QENHSPRMTK;SLQKLDALNLSNNY 2 3.9 0.99064 -0.2097 0 0 0 0 12.8992 0 0 0 0 0 0 0 0 0 0 A0A8P0PLQ6 A0A8P0PLQ6_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ERN1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; mRNA processing [GO:0006397]; regulation of gene expression [GO:0010468]; regulation of primary metabolic process [GO:0080090] endoplasmic reticulum membrane [GO:0005789] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521] EKQLQFFQDVSDRIE;GLPCPPSILLYEE;LGRTEYTITMYDTKTREL;SSGSASKA;VLGHGAEGTIVYRGMF;VTIGDKGECVITPSTDLKF 6 8.9 1.002 -1.2947 9.8899 8.64548 11.2206 0 10.9599 9.85859 9.16892 0 0 11.1178 0 0 0 0 8.72646 A0A8P0PLQ8 A0A8P0PLQ8_CANLF Ig-like domain-containing protein SPEGNB Canis lupus familiaris (Dog) (Canis familiaris) DRVFFEIGSTTTTL;EDDRVFFEIGS 2 7 0.98989 -0.26173 0 0 0 0 0 0 0 0 0 0 0 0 0 5.9692 0 A0A8P0PLR4 A0A8P0PLR4_CANLF Cadherin domain-containing protein LOC119863934 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EVTYSLLERE;HAPHILYPTSTNSSAAIE;KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;LELRRLGP;LLLLLLLP;LLLLLLPL;NGELRYSLSSYTSDRERQL;PPLLLLLL;PPLLLLLLL;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK;VTVEAQDK;VVLTDLYSP;WLPPPLLLLLL 17 12.8 1.0033 -2.2597 8.1819 0 0 0 3.59192 7.89075 0 10.9742 7.66761 0 3.04681 0 9.47474 10.4381 9.21767 A0A8P0PLS9 A0A8P0PLS9_CANLF C-type lectin domain containing 16A CLEC16A Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] LNDILIIN;LTKNTTVT;SSPSLSSPSASGSPSGS;VGGGHGKS;VVKFAGLLQD 5 5.3 1.0032 -1.5502 0 0 10.3349 8.18879 8.79837 8.37517 0 0 0 9.68115 7.13965 9.66459 0 0 7.66299 A0A8P0PLT1 A0A8P0PLT1_CANLF Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) SH3GLB1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] autophagosome membrane [GO:0000421]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741] NDSCGGGP;SLLADEVITVFSVVGM;TYYAQCYQYMLDLQ;VGMDSDWLMGERGNQKG;VPRSSPASSSL 5 13 1.002 -1.8334 7.41032 0 2.98919 0 7.37104 0 7.31116 6.70307 0 3.42626 0 2.43656 0 0 0 A0A8P0PLU0 A0A8P0PLU0_CANLF Integrin subunit alpha 4 ITGA4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] AGQGPGGAPSASCCCCCC;AGQGPGGAPSASCCCCCCCCA;AGQGPGGAPSASCCCCCCCCAC;APSASCCCCCCCCACGCRAGA;ASCCCCCCCC;ASCCCCCCCCA;ASCCCCCCCCACGCR;ASCCCCCCCCACGCRA;ASCCCCCCCCACGCRAG;ASCCCCCCCCACGCRAGA;ASCCCCCCCCACGCRAGAPT;AVLLRTRPVVIVEVSL;CCCCACGCRAG;CCCCCCCACGCR;CCCCCCCACGCRA;CCCCCCCACGCRAGAPT;CCCCCCCCA;CCCCCCCCACGCRAG;CCCCCCCCACGCRAGAP;CCCCCCCCACGCRAGAPTT;GAGQGPGGAPSASCCCCCCCC;GAGQGPGGAPSASCCCCCCCCA;GAGQGPGGAPSASCCCCCCCCACG;GAGQGPGGAPSASCCCCCCCCACGC;GAPSASCCCCCC;GAPSASCCCCCCC;GAPSASCCCCCCCC;GAPSASCCCCCCCCA;GAPSASCCCCCCCCAC;GAPSASCCCCCCCCACGCR;GGAPSASCCCCC;GGAPSASCCCCCC;GGAPSASCCCCCCCCACG;GGAPSASCCCCCCCCACGC;GPGGAPSASCCCCCCCC;GPGGAPSASCCCCCCCCACGC;GQGPGGAPSASCCCCCCCC;IILSSLLLGLILLLLIS;LSSLLLGLILLLLI;PGGAPSASCCCCCCCCAC;PGGAPSASCCCCCCCCACGC;PSASCCCCC;PSASCCCCCC;PSASCCCCCCC;PSASCCCCCCCC;PSASCCCCCCCCA;PSASCCCCCCCCAC;PSASCCCCCCCCACG;PSASCCCCCCCCACGCR;PSASCCCCCCCCACGCRA;PSASCCCCCCCCACGCRAGA;QGPGGAPSASCCCCCCCC;QGPGGAPSASCCCCCCCCA;QGPGGAPSASCCCCCCCCAC;QGPGGAPSASCCCCCCCCACGCR;RQYKSILQEENRRDSWSYVN;SASCCCCCCC;SASCCCCCCCC;SASCCCCCCCCA;SASCCCCCCCCAC;SASCCCCCCCCACG;SASCCCCCCCCACGC;SASCCCCCCCCACGCR;SASCCCCCCCCACGCRA;SASCCCCCCCCACGCRAGAPTTW;SCCCCCCCCA;SCCCCCCCCAC;SCCCCCCCCACG;SCCCCCCCCACGC;SCCCCCCCCACGCR;SCCCCCCCCACGCRAG;SCCCCCCCCACGCRAGAP;SCCCCCCCCACGCRAGAPTTW;SVKLDCSIGYIY;TIAIILSSLLLGLILLL;VGAPMQSTIREEGRVFVYINSGSGA 76 12.6 1.0014 -2.7031 9.38327 7.51735 8.21053 7.99294 8.12908 10.207 11.5158 9.81064 10.0088 8.32683 7.24669 9.04691 10.2555 10.5159 10.3953 A0A8P0PLU2 A0A8P0PLU2_CANLF CKLF like MARVEL transmembrane domain containing 8 CMTM8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PPPPTPPP;TVTTTASSFAENFSTS 2 5 0.98662 -0.2337 0 0 0 0 0 0 0 0 0 0 0 9.16559 0 0 0 A0A8P0PLU4 A0A8P0PLU4_CANLF Sodium voltage-gated channel beta subunit 2 SCN2B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFGHAWLAG;VGASVGGF 2 8.2 1.0017 -1.4089 0 0 0 8.26637 0 8.26369 0 0 0 0 0 0 0 0 0 A0A8P0PLU6 A0A8P0PLU6_CANLF Zinc finger protein 358 ZNF358 Canis lupus familiaris (Dog) (Canis familiaris) ATAHIYHVN;LPQGTYKT 2 3.4 1.0041 -1.1044 0 0 0 0 0 7.91719 0 0 0 0 0 0 0 0 0 A0A8P0PLV6 A0A8P0PLV6_CANLF Dedicator of cytokinesis 2 DOCK2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; small GTPase-mediated signal transduction [GO:0007264] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] EVEGGRGDEQYM;GVAVMDITDII;LDHEVEGG;LIGFSIRDMWYKLGQNK;LVDFLMETFIM;MSFASQSMPTIPA;NYVQKFHYSR;YRGYLLKHKML 8 4.9 1.0024 -1.3897 0 0 0 0 0 0 5.07271 0 4.50989 0 0 0 6.38115 9.41975 0 A0A8P0PLV9 A0A8P0PLV9_CANLF X-ray repair cross complementing 5 XRCC5 Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; telomere maintenance [GO:0000723] Ku70:Ku80 complex [GO:0043564] ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; hydrolase activity [GO:0016787]; telomeric DNA binding [GO:0042162] AQAGTATPPGPWR;ATPPGPWR;EIVIQDGITLI;VYCLNDDNET 4 4.6 1.0021 -1.371 9.87289 0 6.44933 0 0 0 0 0 0 0 0 0 0 0 10.9098 A0A8P0PLX3 A0A8P0PLX3_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP28 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] EALKASNGDI;GVSTKATRSFCRNHCL;LEGASNYS;NWRFEQEVEEW;YKKWHEDYSLFRKVSVY 5 5.8 1.0025 -1.3555 8.92713 0 0 0 0 0 0 9.45964 10.5841 0 0 0 0 0 0 A0A8P0PLX6 A0A8P0PLX6_CANLF phenylalanine--tRNA ligase (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) FARS2 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412]; tRNA aminoacylation [GO:0043039] mitochondrial matrix [GO:0005759] aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; tRNA binding [GO:0000049] DKFEHPNKTLRLGLSRHVED;KASSVSKG 2 5.2 0.98962 -0.19935 9.1763 0 9.20616 0 0 0 0 10.2527 0 9.27536 0 9.54496 8.60766 6.90965 0 A0A8P0PLY3 A0A8P0PLY3_CANLF Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) MBD4 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] DNA binding [GO:0003677]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263] FNLVQETLFH;TEEAEHNRKCQETFLESEEIKSKVE;WERVVKQRL 3 8.4 1.0027 -0.84134 0 0 0 0 0 5.45654 10.5621 0 0 0 0 0 0 8.76752 0 A0A8P0PLY4 A0A8P0PLY4_CANLF RNA binding motif protein 6 RBM6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] AFRTPDGMPVKDLELKEYNTG;LGEYGGDSDYEEEEEEE;QSNETYRDAVRRVMFAR 3 5 0.98785 -0.46541 9.93902 0 0 0 0 0 0 0 0 0 0 0 0 5.19963 0 A0A8P0PLY8 A0A8P0PLY8_CANLF G protein-coupled receptor 19 GPR19 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] IKMFLILNLLFLLSWLP;ILFYQKVVKYIWRIG 2 7.7 0.98342 -0.25663 0 8.00068 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PLZ3 A0A8P0PLZ3_CANLF EPH receptor A10 EPHA10 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] DVWSFGVVMWEV;SPCPEHSRALEN;VLEPNQDNWLQTGWISRG;YGKGGQDAHDEE 4 5.4 0.98646 -0.38751 0 0 0 8.72226 0 0 10.8597 0 0 10.8203 0 0 0 0 0 A0A8P0PLZ5 A0A8P0PLZ5_CANLF Sidoreflexin SFXN5 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial membrane [GO:0031966] monoatomic ion transmembrane transporter activity [GO:0015075] DYKHGTLHPGVTN;LVCLAAFGLALP;PFGTPIVVGLLL;VGLNVLVQK 4 13.7 1.0034 -1.1197 0 0 0 0 0 0 0 8.27947 0 0 0 8.21369 9.95404 0 0 A0A8P0PM03 A0A8P0PM03_CANLF Junction plakoglobin JUP Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; desmosome [GO:0030057]; plasma membrane [GO:0005886] cadherin binding [GO:0045296] DFYFVIGSLMTISSR;DPAAWEAVSI;IVEGCTGALHILARD;LAEPSQLL;PEAEMAQNSVRLNYGI;SAIVHLIN;TMQNTSDLDTARCTTSI 7 12.1 0.99736 -3.5148 0 0 7.74819 0 0 0 10.8426 9.46132 9.77466 0 4.48723 0 0 0 8.68408 A0A8P0PM05 A0A8P0PM05_CANLF Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) ATP1B3 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; sodium:potassium-exchanging ATPase complex [GO:0005890] FGYSRGSPCVL;ISFHRPAAPGS;PVTEPGAG 3 5.6 1.0023 -0.84375 0 0 0 0 0 0 10.1213 0 0 0 0 0 0 0 0 A0A8P0PM06 A0A8P0PM06_CANLF Uncharacterized protein LOC111093468 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CGSCSPCQEGCCMSVCCKPVC;CQETCCEPPCCGCGVSVCCK;CQPSCCNSSPCQEGC;DCQETCCEPPCCGC;DCQETCCEPPCCGCGVSVCC;DDCQETCCEPPCCGCGVSV;EASPCCQQSSCQPSC;ETCCEPPCCGCG;ETCCEPPCCGCGVSVCC;PCCQQSSCQPSCCNSSPCQEGCC;PSACTSSSWQVDDCQE;PSCCNSSPCQEGCCVSVCC;QETCCEPPCCGCG;QPSCCNSSPCQEGCC;SCGSCSPCQEGCCM;SPCQEGCCMSVCC 17 41.2 0.7224 0.26197 6.71342 0 9.27845 2.85214 5.49825 0 6.56016 8.5089 6.7736 0 0 5.34763 6.33666 0 0 A0A8P0PM11 A0A8P0PM11_CANLF Peptidase M14 carboxypeptidase A domain-containing protein CPM Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] GDGDGDGG;LEFAYHHQEQMEAFLKT;NRNFPDAFEPNDVSR 3 8.1 1.0032 -1.6945 0 5.09963 8.74298 0 0 0 0 5.11107 0 9.30643 7.32841 0 0 7.2341 0 A0A8P0PM12 A0A8P0PM12_CANLF Protein kinase domain-containing protein MAPK11 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] NWMHYNQTVDIWSVGC;VGGAAAAAG 2 4.5 0.99206 -0.27195 0 4.63442 0 0 0 0 0 0 0 0 0 0 9.93603 0 0 A0A8P0PM28 A0A8P0PM28_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APQLPTILRVVVVLLLILGAGLF;LPTILRVVVVLLLILGAGL;SYAPQLPTILRVVVVLLLILGAGL;TMSWESRG;WVNFQDKFQK 5 12.2 1.0024 -0.98629 0 0 0 0 0 0 7.72383 6.77768 0 0 0 0 3.79971 0 0 A0A8P0PM30 A0A8P0PM30_CANLF Tetraspanin TSPAN7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SCCMNETDCN;TSPYFLEH 2 7.3 1.0029 -1.7158 0 5.71083 0 0 0 0 0 0 0 4.478 0 0 0 0 0 A0A8P0PM38 A0A8P0PM38_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EEHHLRDY;HNCEVRKALWKGRSGSG;SGSGNFGG 3 10.5 0.97803 0.046227 0 0 0 0 7.21023 0 0 0 0 0 0 0 0 0 0 A0A8P0PM40 A0A8P0PM40_CANLF Elongator complex protein 4 ELP4 Canis lupus familiaris (Dog) (Canis familiaris) tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634] DICCTENCDN;DICCTENCDNSHSL;FIGSERETNPLY;LEEMCWNEG;LTHGYIKLL 5 11.1 1.0032 -1.3281 10.198 0 0 0 0 0 0 0 0 0 0 0 0 0 10.2779 A0A8P0PM73 A0A8P0PM73_CANLF Receptor expression-enhancing protein REEP3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] KNVKEYVRWMMYWIV 1 10.9 0.95029 0.053874 0 11.5741 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PM85 A0A8P0PM85_CANLF "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C" LOC100682872 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ENRLWMTLNFSQ;GISSVQHPHGSSLLDTLQ;KDFLWIFIT;KNINSHILIGAPPMKKKLLTIG 4 13 1.0015 -0.64283 10.9315 0 7.28281 10.9811 0 0 0 0 0 0 0 0 8.22043 0 4.72274 A0A8P0PM87 A0A8P0PM87_CANLF Serine rich single-pass membrane protein 1 SSMEM1 Canis lupus familiaris (Dog) (Canis familiaris) ASATNHMKADI;EENCVPEINT 2 11.5 1.0045 -0.81965 0 0 0 0 0 0 13.1248 0 0 0 7.20428 0 0 0 0 A0A8P0PM92 A0A8P0PM92_CANLF FERM domain-containing protein 8 FRMD8 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; membrane [GO:0016020] VLESTPPP 1 1.9 0.98407 -0.23825 0 0 0 0 0 0 0 0 0 0 0 0 10.1977 0 0 A0A8P0PMA0 A0A8P0PMA0_CANLF Protein GAPT GAPT Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NLSSNCIRTLPDNVLLP 1 5.9 0.9971 -0.10195 0 0 0 0 0 0 11.2801 0 0 0 0 0 0 0 0 A0A8P0PMA6 A0A8P0PMA6_CANLF Leucine rich repeat containing 72 LRRC72 Canis lupus familiaris (Dog) (Canis familiaris) LDQNQVTEKER 1 4.1 0.98389 -0.24477 0 0 0 0 0 0 9.68534 0 0 0 0 0 0 0 0 A0A8P0PMB3 A0A8P0PMB3_CANLF BRISC and BRCA1-A complex member 2 BABAM2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell division [GO:0051301]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212] BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737] polyubiquitin modification-dependent protein binding [GO:0031593] SALHIPAFPGGGCL;VRRQEPNRWATQGSP;YHKRREYIAAFLSHFGTGVVEYDA 3 12 0.99421 -0.16444 0 9.58558 0 0 0 0 0 0 0 6.22672 0 0 0 9.8864 7.54063 A0A8P0PMB4 A0A8P0PMB4_CANLF Protein rogdi homolog ROGDI Canis lupus familiaris (Dog) (Canis familiaris) perikaryon [GO:0043204]; synaptic vesicle [GO:0008021] KISVFSSYWSY;PQEEEFRWLLHDEV 2 6.7 0.98908 -0.20326 0 0 0 0 0 8.56594 0 0 0 0 0 9.90552 0 0 0 A0A8P0PMB9 A0A8P0PMB9_CANLF Ribonuclease H2 subunit B RNASEH2B Canis lupus familiaris (Dog) (Canis familiaris) ribonuclease H2 complex [GO:0032299] GGTGGWGH 1 6.2 0.99005 -0.26592 0 8.99141 0 0 0 0 0 8.92059 0 0 0 0 0 0 0 A0A8P0PMC0 A0A8P0PMC0_CANLF PEST proteolytic signal-containing nuclear protein PCNP Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] PTKPTKISKF 1 6.1 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 9.98939 0 0 A0A8P0PMC2 A0A8P0PMC2_CANLF Zinc transporter SLC30A5 Canis lupus familiaris (Dog) (Canis familiaris) intracellular zinc ion homeostasis [GO:0006882] ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580] metal ion binding [GO:0046872]; zinc ion transmembrane transporter activity [GO:0005385] GVVVSAIF;HSSDHSHSHHMHGH;IDPPELDTHML;YGGDVLAG 4 5.8 1.003 -1.9175 0 11.4986 0 4.87961 0 0 0 9.56951 0 0 0 0 0 0 0 A0A8P0PMC6 A0A8P0PMC6_CANLF X-box-binding protein 1 XBP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] EENQKLLLENQLLRE 1 6.2 0.95345 0.053888 0 0 0 0 0 8.13006 0 0 0 0 0 0 0 0 0 A0A8P0PMC8 A0A8P0PMC8_CANLF Kallikrein-related peptidase 2 KLK2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] PLKTSLSLNF;VRKSFIHPLYKTKVPRAVIR;YGILGEHIGGKGSEARKSPEVRSGD 3 17.6 0.98989 -0.5332 0 0 0 0 0 0 0 7.73288 0 7.51333 0 0 0 0 0 A0A8P0PMD1 A0A8P0PMD1_CANLF Tetraspanin TSPAN19 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVQVVFSAFIIIKKK;HQYLERKRMS 2 9 0.99013 -0.2621 0 4.99977 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PME0 A0A8P0PME0_CANLF Ring finger protein 6 RNF6 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EQLANQPDLRNGTNTREV;HREGERRWQQERLHREEAYYQFINE 2 6.3 0.94338 0.083851 0 0 0 0 0 5.34997 0 5.63006 0 0 0 0 0 0 0 A0A8P0PMF5 A0A8P0PMF5_CANLF Zinc finger and BTB domain containing 33 ZBTB33 Canis lupus familiaris (Dog) (Canis familiaris) PLSNSLKISD 1 1.5 0.98503 -0.2588 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.7151 A0A8P0PMF6 A0A8P0PMF6_CANLF NADH:ubiquinone reductase (H(+)-translocating) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLRTFLSLKLLILII;RTFLSLKLLILIIFS 2 6 0.93259 0.10775 0 0 0 3.86839 0 0 0 0 0 0 0 6.53001 0 0 0 A0A8P0PMF7 A0A8P0PMF7_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.26) SMURF2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] ubiquitin protein ligase activity [GO:0061630] LDPKWNQHYDL;LPEGYEQRTTQQGQ;RDLVQKLKILRQELS 3 5.4 0.87294 0.12775 0 0 0 0 0 0 0 0 9.67525 0 0 0 0 0 0 A0A8P0PMH4 A0A8P0PMH4_CANLF Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) HACD2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] endoplasmic reticulum membrane [GO:0005789] lyase activity [GO:0016829] AGAAAGEAGGARKKKGPG;AKGNGGGG;GGARKKKGPGPLATAYLVI;IYAALPFV;KGNGGGGA 5 14.4 1.0019 -1.2728 0 8.39703 10.9731 0 0 0 0 10.7817 0 13.0546 0 8.83933 10.0876 10.6415 8.32278 A0A8P0PMI4 A0A8P0PMI4_CANLF SIPAR domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVSCGVRDWLGGGPRAINSHR;LCCQKRLEMGISEEEP;LGHLEPVFSEQTV 3 19.2 0.99237 -0.17163 0 0 0 0 7.33154 10.686 0 0 0 0 0 0 9.87267 0 9.40716 A0A8P0PMI7 A0A8P0PMI7_CANLF Transmembrane protein 222 TMEM222 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGPYFVSEDNM;PGLQDRALGQRW;SLCCDNCH 3 12.8 0.9896 -0.51704 0 0 0 0 0 0 0 0 11.2038 0 8.02625 0 0 0 0 A0A8P0PMJ0 A0A8P0PMJ0_CANLF "Upstream transcription factor 2, c-fos interacting" USF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] protein dimerization activity [GO:0046983] GSRRRRRRRRRRRRRRARAAQVKEE;SKTGASKG;SPGVPSGPAFP;SRRRRRRRRRRRRRRARAAQVK 4 6.3 1.0023 -0.98666 7.50692 8.05528 0 0 9.96636 0 0 9.18696 0 0 0 4.53928 0 0 4.7658 A0A8P0PMJ5 A0A8P0PMJ5_CANLF Gamma-aminobutyric acid type A receptor subunit gamma2 GABRG2 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] AECQLQLHNFP;EVVKTTSGDYV;RVLYTLRLTIDAECQLQLH 3 11.4 0.9478 0.085029 0 0 9.05888 0 0 0 0 0 0 0 0 0 9.53048 0 0 A0A8P0PMK3 A0A8P0PMK3_CANLF Guanine deaminase (Guanase) (EC 3.5.4.3) (Guanine aminohydrolase) GDA Canis lupus familiaris (Dog) (Canis familiaris) guanine catabolic process [GO:0006147] guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270] IDLFSGDLVGETSEAVIQ;QITPPTSPKYRK;RHPWKGTERLHN;SIKETERFV 4 10.8 1.0022 -1.2919 0 8.05902 0 0 10.384 0 0 11.5403 11.729 0 0 0 0 0 0 A0A8P0PML6 A0A8P0PML6_CANLF NOP2/Sun RNA methyltransferase 4 NSUN4 Canis lupus familiaris (Dog) (Canis familiaris) LRSPPSSPC;LSSHCPYP;PSPLGNQFISPPQSPP;SSGKSYNDPPLSPACSLPSGSF 4 7.2 1.0023 -0.74058 0 0 0 0 0 0 0 8.75061 0 7.08895 0 0 6.68496 0 0 A0A8P0PML7 A0A8P0PML7_CANLF "Abhydrolase domain containing 16A, phospholipase" ABHD16A Canis lupus familiaris (Dog) (Canis familiaris) AGAGAMAK 1 5.6 0.98969 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 8.06781 9.05555 A0A8P0PMM0 A0A8P0PMM0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740] KGHGGGGA;LARLRRKHRP 2 3 0.9967 -0.59119 0 11.4116 0 0 0 0 0 0 0 12.4635 0 12.1986 0 0 0 A0A8P0PMM2 A0A8P0PMM2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) ERINKIDKPLVSLIKKKREKTQI;MDAFLESHKL 2 4.4 0.97809 0.046253 0 0 0 0 0 0 0 0 0 0 0 0 5.74203 0 0 A0A8P0PMP1 A0A8P0PMP1_CANLF Cyclin L2 CCNL2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nuclear speck [GO:0016607] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] DTETDLRVVGC;DTETDLRVVGCE;ESPKEGKGNKASPL;MNDSLRTDVFVRFQPESIACACIYL;TDTETDLRVVGC 5 10.1 0.20339 0.75708 13.293 11.0244 13.3082 12.9652 0 0 13.9523 13.9452 14.0653 10.2377 12.635 11.9269 13.4422 11.1525 13.5843 A0A8P0PMP3 A0A8P0PMP3_CANLF A-kinase anchoring protein 9 AKAP9 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] centrosome [GO:0005813]; cytoplasm [GO:0005737] DNA binding [GO:0003677]; molecular adaptor activity [GO:0060090] AEIHCLQERLQ;AINELNIKLQ;DRRSLLSEIQAL;DRTRNWVLQQKIE;DTLASEQKKSREL;ELLEKQMKEKEDDLQ;GVMTITSKD;KALEIDVEE;LNEVIEKLQQELANIEQK;NDKLQWELSVLKSEQNDLR;PESEISTT;QNEMSQKIETMQF;REQENDQPNQEL;SETETLKREHYVA;TEKSTNLLREE;TSLILEKERVEIVE;VEQLTNHLKEKTD;VLLESEKVRIQEMSST;VTEEYNKLLV;VTPESALIKRDEVFSVE;VVFQEEICIEMC 21 7.1 0.94744 0.05044 8.02303 0 0 0 0 0 0 0 0 0 0 0 0 8.98604 0 A0A8P0PMP8 A0A8P0PMP8_CANLF Mitochondrial carrier 2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] HVITLRSMVHFI;HVITLRSMVHFIG;VITLRSMVHFIG;WIPSLLPNIYF 4 12.2 0.98421 -0.23843 10.6609 0 0 9.15393 0 0 0 0 12.4869 0 0 5.76232 0 16.4164 0 A0A8P0PMQ4 A0A8P0PMQ4_CANLF Leucine rich repeat containing 4 LRRC4 Canis lupus familiaris (Dog) (Canis familiaris) synaptic membrane [GO:0097060] QTHTKDKVQETQI 1 2 0.98342 -0.25541 0 0 0 0 0 11.4309 0 0 0 0 0 0 0 0 0 A0A8P0PMR2 A0A8P0PMR2_CANLF Claudin CLDN8 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] KSPSVYSRKCLCQ;PDLQASRGLMCA 2 10.9 0.9928 -0.55379 0 0 0 0 0 0 0 0 0 0 0 0 12.6166 0 0 A0A8P0PMS0 A0A8P0PMS0_CANLF Sodium voltage-gated channel alpha subunit 2 SCN2A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] monoatomic cation channel activity [GO:0005261] LEDLDPYYI;LFVPHRHG;PIRKLAIKILVTLFNVLIM;PIRKLAIKILVTLFNVLIMC;QLKKQQEEAQ;SKLSSKSEKELKNRRKKKKQKE 6 9.4 0.93503 0.097616 0 6.69181 0 3.37657 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PMS1 A0A8P0PMS1_CANLF Protein Wnt WNT4 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] EVMDSVRRGAQLAIE;GRAWQAGPGRPPSQRPLCTPAG;GVAFAVTRA 3 12.2 0.9923 -0.033118 0 0 0 0 0 0 0 0 0 0 0 0 8.53052 0 10.8946 A0A8P0PMT6 A0A8P0PMT6_CANLF "Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA)" ISCA1 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] mitochondrion [GO:0005739] iron-sulfur cluster binding [GO:0051536] TKGDSDEEVVQDGV;YTLEYTKTKGDSD 2 16.3 0.69231 0.28611 0 0 0 0 0 0 0 16.8722 16.9309 0 0 0 0 0 0 A0A8P0PMT9 A0A8P0PMT9_CANLF Monooxygenase DBH like 1 MOXD1 Canis lupus familiaris (Dog) (Canis familiaris) copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500] LAYDDDFDFNFQEFQ;LVNQDVEPVIQ;VGEAGPKYHDSNR;VLSLPVNVRCS 4 8.5 0.9891 -0.20391 6.808 10.3797 6.59603 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PMU3 A0A8P0PMU3_CANLF C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) C5AR1 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] membrane [GO:0016020]; vesicle [GO:0031982] complement receptor activity [GO:0004875]; G protein-coupled receptor activity [GO:0004930] SIVQQGYWPFG 1 3.2 0.98183 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 7.06264 0 0 A0A8P0PMV6 A0A8P0PMV6_CANLF Trafficking protein particle complex subunit 13 TRAPPC13 Canis lupus familiaris (Dog) (Canis familiaris) GAEILMLGEMLT;SSQRLNLSASNAAVAEL 2 7.1 0.9906 -0.19585 0 0 0 0 0 0 0 10.4432 10.9004 0 0 0 0 0 0 A0A8P0PMW0 A0A8P0PMW0_CANLF Synemin SYNM Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] intermediate filament [GO:0005882] structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307] VIACLEDEKAALTLAM 1 4.7 0.99199 -0.040836 0 0 10.6243 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PMW3 A0A8P0PMW3_CANLF Homeobox domain-containing protein SIX5 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GAEGPGSPGVPGSPPEAAAEPPT;TSLPFADSSALLPGF;VPEGALPVAPSP;VPGPPPAA;WAAPPWHHLSQVVAGGPGHAA 5 9.6 1.0023 -0.66549 0 0 0 0 0 0 0 0 0 0 10.2256 0 0 0 0 A0A8P0PMY1 A0A8P0PMY1_CANLF Uncharacterized protein FAM156A Canis lupus familiaris (Dog) (Canis familiaris) methylated histone binding [GO:0035064] LEMQQESKRM;QSHRPNVSGMPA 2 10 0.99211 -0.29118 0 0 0 0 0 16.7128 0 19.9321 0 20.1219 10.9528 0 0 20.2441 11.7399 A0A8P0PN09 A0A8P0PN09_CANLF Chromo domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] YFLKWKGFIDA 1 14.9 0.98382 0.035491 0 0 0 0 0 0 10.9615 0 0 0 0 0 0 0 0 A0A8P0PN22 A0A8P0PN22_CANLF U3 small nucleolar RNA-associated protein 15 homolog UTP15 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] LDRVLEPSCTI;SIIKELNRRGVLANALAGRDEK;VEKEIDYQRELLE 3 9.4 0.87237 0.14203 0 0 0 0 0 0 0 0 0 7.42719 0 0 0 5.51412 10.365 A0A8P0PN32 A0A8P0PN32_CANLF Scribble planar cell polarity protein SCRIB Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] EEDEEEDEEEEEVAV;GGKGSTPYRAGDGGI;GVGRRNSLES;HNGPHTPWAPRAEEEDEEDEEEDEE;LDLDGEAPDDEEPE;LGCDPGDP;MVPPGTTGGKMAEGP;PMASPEQLSFRER;PSPGLQEEAGRRGPREPGRAAE;SIAGGKGS;SLDLDGEAPDDEEPE 11 8.4 0.9893 -0.51824 0 0 0 0 0 9.42032 0 0 0 0 0 8.37413 0 0 0 A0A8P0PN39 A0A8P0PN39_CANLF Olfactory receptor OR8S1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISVECCLTQVFF 1 3.8 0.95489 0.05044 0 0 0 0 0 0 0 0 0 0 2.86467 0 0 0 0 A0A8P0PN56 A0A8P0PN56_CANLF Protein phosphatase 2 regulatory subunit B'beta PPP2R5B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] protein phosphatase type 2A complex [GO:0000159] protein phosphatase regulator activity [GO:0019888] EPSWPHLQLVYEFF;KQFLVRVLIPLH;QSLLEELIGSLCFFCWSL;VGGKRRLKHL 4 9.4 1.0026 -0.72637 7.34616 0 0 0 5.70454 0 0 0 11.6146 0 0 0 0 0 0 A0A8P0PN59 A0A8P0PN59_CANLF Eukaryotic elongation factor 2 kinase (EC 2.7.11.20) EEF2K Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686] EQYGSSGSPAS;LLPHSKQFQP;SENSGDSGYPSEK;SGDENMSDVTFDSL 4 7.3 0.98817 -0.49394 0 8.25569 0 0 0 0 8.69167 0 0 0 0 0 0 0 0 A0A8P0PN69 A0A8P0PN69_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CWWERELVPPLWKTVWWFLKELKI;GTLLHCWWECELVHCWWERE 2 9.7 0.93852 0.089509 0 0 0 0 0 7.37191 6.21473 0 0 0 0 0 0 0 0 A0A8P0PN70 A0A8P0PN70_CANLF Neurogenic locus notch homolog protein 1 NOTCH1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; developmental growth [GO:0048589]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023] ATALNGQCEWLSRLQN;DGHCDQGCNSAECEWD;DVNECISNPCQNDA;EEDINECASNPCRHG;FLTPSPESPDQW;GDGHCDQGCNSAECEW;GVATFTCLCQPGY;MDDNQNEWGDEDLE;NTLGSFECQCL;PSLQPPTIQQ;PSQHSYSSSPADNTP 11 5.9 1.0029 -1.6647 0 10.1496 0 10.099 5.6222 0 5.12462 0 10.37 9.23704 0 0 8.84709 8.97396 8.51724 A0A8P0PN75 A0A8P0PN75_CANLF Centrosomal protein 131 CEP131 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport involved in cilium assembly [GO:0035735] cilium [GO:0005929] ELRARQRLELE;KARQARRAAIQ;SEGVDLSLTGLPPPVSWRPN;SIMSFLHEMEM;TLLSEAKL;WGRTRGWVGGAGS 6 6.8 1.0021 -0.65666 10.4884 0 9.21868 7.90671 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PN93 A0A8P0PN93_CANLF Choline kinase alpha CHKA Canis lupus familiaris (Dog) (Canis familiaris) GGGGCDAPG;GGGGGGGG;GGGGNAAP 3 5.9 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 4.96236 0 0 0 0 0 A0A8P0PNA6 A0A8P0PNA6_CANLF FERM and PDZ domain containing 2 FRMPD2 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EDSLDYVICPWSA;GPESFQRATGEVQWDQDLE;IVSCPEWTGRFHA;LPLQSVLEACRVH;LYWSAGFHVPQNQPLRLRE;VEVSEMHC 6 6.5 0.99169 -0.54391 0 14.737 8.20242 0 6.29536 14.9557 0 0 11.1124 0 0 0 0 13.3108 0 A0A8P0PND0 A0A8P0PND0_CANLF Mab-21-like HhH/H2TH-like domain-containing protein ITPRIPL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LESFYKHYV;RMDLDTLARSRQLEKRMSEEMRQ 2 5.7 0.98949 -0.19955 0 8.87252 0 0 0 0 0 9.96558 0 0 0 0 7.76706 0 0 A0A8P0PND2 A0A8P0PND2_CANLF PPM-type phosphatase domain-containing protein PPM1L Canis lupus familiaris (Dog) (Canis familiaris) protein serine/threonine phosphatase activity [GO:0004722] CLIALLSDKDLTVANVGDSR;LDKLQPEFMILASD 2 14.8 0.9112 0.11108 0 0 0 0 0 0 0 7.52403 0 0 0 0 7.25039 0 0 A0A8P0PND9 A0A8P0PND9_CANLF Hexosyltransferase (EC 2.4.1.-) B3GNT8 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] DLSSLVTWESH;MRCPKCLLCLSALLTLL;PGPTPASPEPTLPAN;SPEGEGGP;VASCSGTDVPYL 5 15.9 1.0012 -1.3157 0 0 12.8133 0 9.13522 9.14303 0 0 0 0 9.35423 0 0 8.87541 0 A0A8P0PNE0 A0A8P0PNE0_CANLF Neutral cholesterol ester hydrolase 1 (EC 3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1) NCEH1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] carboxylic ester hydrolase activity [GO:0052689] NSYIKWLDQN 1 2.5 0.98465 -0.23794 0 11.6408 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PNE2 A0A8P0PNE2_CANLF D-aminoacyl-tRNA deacylase (EC 3.1.1.96) LOC119865107 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] D-aminoacyl-tRNA deacylase activity [GO:0051499] LQVRPAEGDAESQWVEVQR 1 11.7 0.953 0.049538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9243 A0A8P0PNE6 A0A8P0PNE6_CANLF Protein arginine N-methyltransferase 5 (EC 2.1.1.320) PRMT5 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; rhythmic process [GO:0048511] cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] protein-arginine N-methyltransferase activity [GO:0016274] GAQHFLKDDGVSIPGEYTSFL;LQELNFGAYL;VTVVSSDMREWV 3 7.2 1.0037 -0.80452 0 0 0 9.55417 0 9.88147 0 8.57815 5.12924 0 0 0 0 0 0 A0A8P0PNE7 A0A8P0PNE7_CANLF Tensin 2 TNS2 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925] metal ion binding [GO:0046872] APAGPLASAESPEP;EAPARSGLE;FDPLEETPEAPAPANMS;FGWPELHAPPLD;IYHIAGPG;PVERLLRA 6 4.9 1.0034 -2.062 0 0 0 0 0 0 11.2271 0 12.6004 7.66811 0 0 11.99 0 0 A0A8P0PNF6 A0A8P0PNF6_CANLF Zinc finger protein 106 ZNF106 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AETRGNKKKKKLRKKK;ALGISSLADAATDSSCTSGTE;APSDCTASYEAV;DLKTSLEDAQVDDPVK;FQAHGSVPAPDSSIQIKQEPMS;FSLTTTGT;HAVTVVNILGKVM;IEMVPLVQNEQEVLDLDGE;IKGKKERSQ;KGKKERSQVDQ;KKKKKLRKKKT;KKKKKLRKKKTLRA;KKKKKLRKKKTLRAA;KKKKKLRKKKTLRAAHV;KKKKKLRKKKTLRAAHVP;KKKKLRKKKTL;QTSGKNAALYTGSS;SDHTIRCYN;SEPGDDDE;SFHEPSQEL;VEVQRLLLLKQQ 21 10.9 0.99677 -4.5406 10.0616 7.36177 0 9.40374 8.84358 0.297367 9.41329 0 9.90676 0 0 0 10.7278 6.60429 11.9787 A0A8P0PNF9 A0A8P0PNF9_CANLF Fibrous sheath interacting protein 2 like FSIP2L Canis lupus familiaris (Dog) (Canis familiaris) ASSSELVLE;DKKSSFQYYLS;EEQQHQDH;EIPAEGQLCNVLQ;ERPELKHSRQGKCSVRFMSYDSKP;ESFADLQFKHISMYA;ESIETMKPIFI;ETALSQPWLS;IEKVVTSV;ISNSEFHPQV;IVHSSICNILREY;KEHIQNLVSNIF;KRKMKFLSVL;LEDYDVSGLLENLAE;LPDECPNW;LVTHDIGQEVSENKVEEGLT;PSLFLYSEE;QVESLVLGE;RKDILRRLKKGGYITSNN;SFWERKTQLSREEM;SPLEDYDVSGLLE;TIYTDISNSNLYQSL;VHSSICNILREYRSQDSI;VLEFTTSEILVADH;YLLHPLFSGDLSA 25 4.4 0.99672 -4.684 8.60236 10.4539 10.8395 13.1763 10.0467 7.88368 10.0051 10.5454 11.325 0 12.64 9.5126 13.122 11.5599 11.8677 A0A8P0PNH4 A0A8P0PNH4_CANLF Zinc finger protein 213 ZNF213 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GVHTGQKPFSCSQC;PLACAAGA 2 4.8 1.004 -1.0434 7.58195 0 0 0 0 0 0 0 11.8248 0 0 0 0 0 0 A0A8P0PNI0 A0A8P0PNI0_CANLF Elongin B ELOB Canis lupus familiaris (Dog) (Canis familiaris) transcription elongation by RNA polymerase II [GO:0006368] elongin complex [GO:0070449]; VCB complex [GO:0030891] AGLELMFSPCP 1 11.8 0.99111 -0.14526 0 0 0 0 0 0 0 0 0 9.83529 9.46612 0 0 0 0 A0A8P0PNK0 A0A8P0PNK0_CANLF Sprouty RTK signaling antagonist 4 SPRY4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] membrane [GO:0016020] DEGSCADHPCSC;GVFYHCTNEDDEGS;GVFYHCTNEDDEGSCADHPC;GVFYHCTNEDDEGSCADHPCS;QGVFYHCTNEDDEGSCADHPCSC;YHCTNEDDEGSCADH;YHCTNEDDEGSCADHPCSCSR 7 8.4 0.9887 -0.2642 0 0 11.3018 5.76495 0 0 7.24174 7.59582 9.39564 0 0 5.25622 6.23735 0 0 A0A8P0PNK2 A0A8P0PNK2_CANLF Follistatin-related protein 1 (Follistatin-like protein 1) FSTL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] EARGASGARAGVPGPARSSSRSLGA;LCIEQCKPHKRPVCGSNGKTY;VGFPRRLPRRGAASVPRAR 3 12.1 0.9946 -0.15897 0 10.0163 0 0 0 0 0 10.2765 0 0 7.874 0 0 0 0 A0A8P0PNK6 A0A8P0PNK6_CANLF LY6/PLAUR domain containing 1 LYPD1 Canis lupus familiaris (Dog) (Canis familiaris) side of membrane [GO:0098552] RCWRRRRHLRLL 1 3 0.94701 0.05044 0 0 0 0 0 0 6.97384 0 0 0 0 0 0 0 0 A0A8P0PNK8 A0A8P0PNK8_CANLF Ribosomal protein L7 like 1 RPL7L1 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KGKKLKFKRLEWFLHDSWRQQRDR;KQRKKIPLVPENLLKKRKAY 2 18.1 0.93791 0.089509 8.90448 0 6.01438 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PNM0 A0A8P0PNM0_CANLF SOCS box domain-containing protein RAB40B Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EQAQAYAERLGVTF;GAGGGGRT;GVTFFEVSPLCNFNITESFTELAR;VYDIANRWSFDGIDRWIKEIDEHAP 4 23.3 1.0038 -0.80844 0 0 0 10.0825 0 0 0 12.6682 0 0 0 0 0 0 9.11499 A0A8P0PNN5 A0A8P0PNN5_CANLF C3H1-type domain-containing protein ZC3H10 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CRFIHGSKEDEDGYKKT;NEVLLEQNAQFRNQ;PVPSGRRHDL;QPLAGITMSHTTTPMVT;RGVECRLLEEEN 5 16.1 0.98595 -0.41511 0 0 9.46583 0 8.3087 0 0 0 0 0 0 0 0 0 7.95675 A0A8P0PNN7 A0A8P0PNN7_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Zinc/RING finger protein 3) ZNRF3 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; transferase activity [GO:0016740] DELPAAHGQ;GALDTLSS;GGTPGPDA;GVAGGSTL;SPSGDQLSTCSLEMNYS 5 5.8 0.99709 -4.0712 0 0 0 8.72448 5.10056 0 10.2504 0 0 0 0 6.65707 0 8.28827 9.37656 A0A8P0PNP1 A0A8P0PNP1_CANLF Insulin-induced gene protein INSIG2 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] ASAKVDFDNNIQLS;LVTMYIFCWR;SLCSFLVTMYIF 3 13.9 0.99163 -0.13863 0 0 9.43869 0 0 0 10.9346 0 0 0 0 0 0 8.80313 0 A0A8P0PNQ3 A0A8P0PNQ3_CANLF Protein phosphatase 4 regulatory subunit 3B PPP4R3B PNPT1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] EDEEMWFNEDEEEEGKAVV;EEDEEMWFNEDEEE;HREFLTKT;LEEDEEMWFNEDEEEEG;PALAQPKRHR;YPDDEEEDEEE 6 6.3 0.9938 -0.072339 0 0 8.90442 0 6.33989 0 0 0 10.5178 0 3.68975 0 0 0 0 A0A8P0PNQ9 A0A8P0PNQ9_CANLF PNMA family member 6E PNMA6E Canis lupus familiaris (Dog) (Canis familiaris) VFLATREDEDAPASAGLGQGR 1 3.9 0.95511 0.050705 0 0 0 0 0 0 0 0 6.31714 0 0 0 0 0 0 A0A8P0PNR2 A0A8P0PNR2_CANLF VWFA domain-containing protein MATN1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ENFELVKKFINQ 1 2.4 0.9448 0.05044 0 0 0 0 7.15634 0 0 0 0 0 0 0 0 0 0 A0A8P0PNR4 A0A8P0PNR4_CANLF "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II)" HAGH Canis lupus familiaris (Dog) (Canis familiaris) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] mitochondrial matrix [GO:0005759] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] KYSIGEPTVPSTIAEE;TTVLTTHHHWDHAGGNEKLVKL 2 14.6 0.91839 0.11217 0 0 0 0 0 6.14337 10.7845 0 0 0 0 0 0 0 0 A0A8P0PNS2 A0A8P0PNS2_CANLF C-type lectin domain-containing protein KLRG1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CTSCYSCPDLWMRYGNH;PLQPNGGV 2 12 1.0038 -1.1044 0 0 0 0 0 7.25673 0 0 6.69307 0 0 0 0 0 0 A0A8P0PNT3 A0A8P0PNT3_CANLF Uncharacterized protein FANCF Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] ARPQRLDRPAA;RGSGSGSGSARGRMESLLQ;RRRPGRAVPRPPRR 3 8.8 0.987 -0.23107 0 0 0 0 0 8.46046 0 0 0 0 5.09111 8.34043 0 10.3998 3.7301 A0A8P0PNT8 A0A8P0PNT8_CANLF Solute carrier family 25 member 20 SLC25A20 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KTLVREKKKKKKKGI 1 4.9 0.95689 0.053874 0 0 0 0 0 0 0 5.57204 0 0 0 0 0 0 0 A0A8P0PNT9 A0A8P0PNT9_CANLF Uncharacterized protein INSM1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GTRQAAAAAAATATRRA;RGPRRRHPRRRRA 2 6.4 0.99067 -0.5375 0 0 0 0 0 0 10.6892 0 0 0 0 0 0 0 8.36602 A0A8P0PNV7 A0A8P0PNV7_CANLF Methyltransferase like 25 METTL25 Canis lupus familiaris (Dog) (Canis familiaris) ALSISNAHTVDFYTESVWEQLI;ANKERRKMTSKSN;CQYLKEERWCCG 3 10.2 0.99287 -0.065118 0 0 0 0 10.0285 0 0 7.99078 5.47151 0 0 0 0 0 0 A0A8P0PNX4 A0A8P0PNX4_CANLF Zinc finger protein 142 ZNF142 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EEIAETHPVAFRPLDP;EQGKFHCNSCTF;FKKRTHLVEH;LVEHLHLHFP;LYPCRYCSYQSRHKQ;SCPTCPFSCQQERAL;SNRGILEPV 7 5 1.0031 -1.9198 10.0228 10.4257 0 0 12.7718 0 0 9.74381 0 0 0 0 10.3765 0 0 A0A8P0PNX8 A0A8P0PNX8_CANLF Ribosomal protein L22 like 1 RPL22L1 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] TVVSEKQFSKRYLK 1 11.8 0.93725 0.060951 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.67483 A0A8P0PNY9 A0A8P0PNY9_CANLF Vesicle amine transport 1 VAT1 Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] AEAAGDTQPPATSEGAAA;DEIKKISP;KAEAAGDTQPPATSEG;SEGAAAAS;VGEGVNDR 5 10 1.0018 -2.6416 8.28105 0 0 0 7.66541 0 7.78823 0 0 0 9.65422 0 9.72596 0 0 A0A8P0PNZ1 A0A8P0PNZ1_CANLF Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (EC 2.4.99.18) STT3A Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789] metal ion binding [GO:0046872]; oligosaccharyl transferase activity [GO:0004576] GAGLLAAAMIA;ITAMANRTILVDNN;KSKKQQDSTYPIKNEV;TDTGKHIKEHD 4 8.5 1.0027 -0.71975 0 0 0 0 8.85801 0 0 0 0 0 0 9.67145 10.4024 0 0 A0A8P0PP10 A0A8P0PP10_CANLF "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4" ST6GALNAC4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] GPCGAPVL;ILLCCWACLPFCP;TLGGRTYRTLLQLTKMYPG;VYTFTEHMMAYCDQVFQDE 4 20.1 1.0041 -1.1044 0 0 0 0 0 0 0 7.99373 0 0 0 0 0 0 0 A0A8P0PP11 A0A8P0PP11_CANLF Rho GTPase activating protein 44 ARHGAP44 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] GTPase activator activity [GO:0005096] PPPDQSPHTLRKVSKKLAPI;SPSGLGLQPGAER 2 4.4 0.94919 0.050068 10.2435 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PP28 A0A8P0PP28_CANLF SLIT-ROBO Rho GTPase activating protein 3 SRGAP3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DLIDCCDL;IVVMRYLFAFLNH;RGLGPSIDTPP 3 3.1 0.93206 0.098745 9.18356 0 0 9.4389 0 0 0 0 0 0 0 0 0 0 9.90123 A0A8P0PP35 A0A8P0PP35_CANLF Palmdelphin PALMD Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane [GO:0016020] EDIRYNIVHSLPSDM;EDPSLTALR;EMKKQNQQ;PVEVEELLRQASE;VLSSIPLPSD 5 10.5 1.0029 -1.7137 0 0 0 9.04723 0 0 0 0 8.6541 10.4535 0 0 0 0 0 A0A8P0PP48 A0A8P0PP48_CANLF Sterile alpha motif domain containing 9 like SAMD9L Canis lupus familiaris (Dog) (Canis familiaris) ISMEYGTEKK;KLITYKATSHEDYF;TYQLSSKEQ;VLKNKTTDFEEIV;VLSNIDHDL 5 3.5 1.0025 -1.2005 8.86199 7.68769 0 0 12.1082 0 0 0 0 0 0 0 0 0 0 A0A8P0PP51 A0A8P0PP51_CANLF HTH cro/C1-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] PNNQVLGKIERAIGLK;PTKYCQEQD;SLGMDGVTLEV 3 24.2 0.9877 -0.26467 0 9.9867 0 0 0 0 0 0 0 0 0 0 0 0 6.43298 A0A8P0PP54 A0A8P0PP54_CANLF Small ribosomal subunit protein uS17 (40S ribosomal protein S11) RPS11 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LSPCFRDVQIGDIVTVGE;SKTIFPVLGLAQCTCTFARG;VHLSPCFRDVQIGDI 3 21.2 0.99407 -0.019209 9.25993 0 9.12353 0 6.24479 0 0 0 10.3738 0 0 0 8.78143 9.10402 8.95297 A0A8P0PP70 A0A8P0PP70_CANLF FZ domain-containing protein COL18A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] DDILASPPRLLD;GADAAPSALSSDP;GHKGEIGFPGRP;GLPGVKGDPGIVGPPGA;LLLLLLLTCCPAAAQ;PGPPGPPGTM;TMGTSSGV;TMGTSSGVRIWAT;VPEGWLMFVAEREE 9 6.1 1.002 -2.6076 0 0 12.9944 0 9.35339 8.21067 0 8.70888 0 8.88597 9.25809 0 0 7.57728 9.17754 A0A8P0PP85 A0A8P0PP85_CANLF "SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)" SPNS3 SPNS2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AEGGGVLQPAPGGPPAAGA;EGGGVLQPAPGGPP;LQITAGHILGDAGS;PTVLGDLFVRDQ;RPSPGTPDS 5 9.5 1.0032 -0.86874 8.54724 0 0 0 0 8.78869 0 0 0 0 0 0 13.2267 10.4462 0 A0A8P0PP88 A0A8P0PP88_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEEKREKELKDH;EDAERDRGLE 2 12.9 0.99017 -0.26665 0 0 0 0 0 0 0 0 0 0 0 0 0 8.72072 0 A0A8P0PPA5 A0A8P0PPA5_CANLF Rap-GAP domain-containing protein RAP1GAP Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] AAGGGGGG;GHVSQEPK 2 2.2 0.98992 -0.2636 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6519 A0A8P0PPB2 A0A8P0PPB2_CANLF Transmembrane protein 25 TMEM25 Canis lupus familiaris (Dog) (Canis familiaris) GVTSASLPAPGEHCQ;VTVNTSDFLVL 2 7.6 0.95415 0.053882 0 0 0 0 0 0 9.91685 0 0 0 0 0 0 0 0 A0A8P0PPC5 A0A8P0PPC5_CANLF Muskelin 1 MKLN1 Canis lupus familiaris (Dog) (Canis familiaris) FHSKNRCLYVFGGQRS;LQEEEPCPRFAHQLV;LVFDHQMCMDSEKHMIY;NILVDKPNDQSSRWS 4 9.5 0.81963 0.20324 0 0 0 0 7.21393 0 0 6.50091 0 8.1822 0 0 0 7.98567 0 A0A8P0PPE0 A0A8P0PPE0_CANLF Fasciculation and elongation protein zeta 1 FEZ1 Canis lupus familiaris (Dog) (Canis familiaris) DEEFEDLRPCCSE;ETLQDEEVWDALTDNYIPSL;RDELEFEKEVKNSFIT;VLEEEDEGE 4 15.7 1.0011 -0.64531 0 6.82604 0 0 4.22172 0 0 0 0 8.86706 0 0 9.63261 0 0 A0A8P0PPG0 A0A8P0PPG0_CANLF Zinc finger RING-H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] AVAMWSWDMECN 1 10.8 0.94468 0.05044 0 0 0 0 0 6.6799 0 0 0 0 0 0 0 0 0 A0A8P0PPG2 A0A8P0PPG2_CANLF Transmembrane p24 trafficking protein 4 TMED4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] GRWGDRRCCCSRC;PSTHANVR 2 3.9 0.98896 -0.52229 0 0 0 0 0 0 9.67428 0 0 0 0 10.4596 0 0 0 A0A8P0PPG9 A0A8P0PPG9_CANLF Caveolae associated protein 3 CAVIN3 Canis lupus familiaris (Dog) (Canis familiaris) caveola [GO:0005901] EPPQDTKEDP 1 3.8 0.99971 -0.61146 0 0 0 3.53094 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PPH4 A0A8P0PPH4_CANLF 60S ribosomal protein L29 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] APALAPASTPASTPAAQAPK 1 11.8 0.94807 0.055002 0 0 0 0 0 0 0 0 0 0 0 0 0 7.61758 0 A0A8P0PPI5 A0A8P0PPI5_CANLF Protein CASC3 CASC3 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]" cell projection [GO:0042995]; cytoplasm [GO:0005737]; exon-exon junction complex [GO:0035145] mRNA binding [GO:0003729] ARGGGSCSGSAGGGGSGSLPS;EAGGQHGG;HYYDPLQF;SPEKEEAVS;VMNFGNPSYPYA 5 8.3 1.0014 -2.6849 7.89087 9.77679 0 10.9084 8.70874 0 0 0 5.29884 0 0 8.18428 0 7.06221 0 A0A8P0PPJ1 A0A8P0PPJ1_CANLF Cystathionine beta-synthase (EC 4.2.1.22) CBS Canis lupus familiaris (Dog) (Canis familiaris) cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343] cytoplasm [GO:0005737] cystathionine beta-synthase activity [GO:0004122] GRDPGAAG;HNEIPNSHILDQYR;HYDTTAEEILQQCD;VASAGTGG 4 6.9 1.0034 -2.3937 10.9008 10.9046 0 0 0 8.66622 10.573 11.1051 10.6864 0 7.12897 0 0 10.635 13.6526 A0A8P0PPJ7 A0A8P0PPJ7_CANLF Protein tyrosine kinase 2 PTK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] LQEASEVISASKEVQFGSSIFD 1 17.7 0.93828 0.06311 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.00907 A0A8P0PPK5 A0A8P0PPK5_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TTC3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; transferase activity [GO:0016740] AENAPGNQIVPKTQ;ALKKVALRLKKKRK;ALKKVALRLKKKRKK;ALKKVALRLKKKRKKKNI;ALRLKKKRKKKNIKT;CIALKKVALRLKKKRKKK;DNCIALKKVALRLKKKRKKKNIK;EVNPEKNNEVTNTPHTQMVAIQ;GYKIENKILAMEEALNWVKYT;HQEVNTEPYDPFE;IALKKVALRLKKKRKKKNI;IDNCIALKKVALRLKKKR;KEIQESLKALTKKMRKVL;KKVALRLKKKRKKKN;LKKVALRLKKKRKKK;LKKVALRLKKKRKKKNIK;LKKVALRLKKKRKKKNIKT;LNFVETEKDSRKTNREMA;LRLKKKRKKKNIK;SEISLKKLQHLELMEDI;SISTSHEAGN;TEDYTTCFS;VLNANEIYAQKNDGKEKEHE 23 9.5 0.99098 -0.27225 6.79051 9.67269 10.9915 0 12.2656 7.65542 10.3282 5.3799 12.5256 0 0 10.3734 8.91181 9.86884 6.91013 A0A8P0PPL9 A0A8P0PPL9_CANLF Actin related protein 6 ACTR6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AIVYSIQNLPEE;FYRDMDIAKLK;KKKKEAIIRINVG;LTNHLKEIISYRQLHVMDE;SENDDFEDMVVT;VINQVKEDVCYVSQDFYRDMDIAK 6 28.7 0.99657 -0.099454 8.29627 8.44025 0 0 6.04433 0 0 8.96743 10.647 0 0 0 0 13.1539 5.21618 A0A8P0PPM7 A0A8P0PPM7_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR27 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] APPGALGCKLLAFLA;ERLAGWPCAAMLVCAAWALA;FLLLLAVVVGATHLVYLR;GGDDEDAPCA;GGGGGGGE;GGGGGGGG;LTASVWLTFA;PGGGGGGG;RKMRPARLVPAV;VLDGGGGDDEDAPCAL 10 27.5 1.002 -1.4315 0 0 0 0 7.87633 0 12.7066 0 0 0 0 0 10.0037 11.734 0 A0A8P0PPP0 A0A8P0PPP0_CANLF Transmembrane protein 132E TMEM132E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGEDDEEDEEDL;DLGWGCPDVAGS;EAAGESQQAELYYTLHAPDA;EDEDEEEE;LSLWLSYSDGTTAPLSL;SGGCGGGR;VDSSTLAGLEPGTT 7 8.3 1.0025 -1.1318 0 9.96924 0 6.54071 0 0 0 9.75847 11.4623 8.76354 0 0 8.6908 7.62812 0 A0A8P0PPQ0 A0A8P0PPQ0_CANLF BOS complex subunit TMEM147 (Transmembrane protein 147) GAPDHS Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVHYIVASAQ 1 3.2 0.99884 -0.61146 0 0 0 0 0 0 0 0 0 0 0 7.14659 0 0 0 A0A8P0PPR0 A0A8P0PPR0_CANLF Elongation factor 1-gamma (eEF-1B gamma) TUT1 Canis lupus familiaris (Dog) (Canis familiaris) translation elongation factor activity [GO:0003746] AFEGDDGFCVFESNAIAYYV;LTQKAGEGEQ;QELAFPLSPD;SLCSELDERVRPLV 4 8.8 0.9903 -0.21522 0 0 0 0 0 0 0 0 9.28857 0 0 0 0 7.54967 0 A0A8P0PPR6 A0A8P0PPR6_CANLF Transmembrane protein 191C TMEM191C Canis lupus familiaris (Dog) (Canis familiaris) CSSCARAACCPPSASRWPRPP 1 4.4 0.94568 0.0504 0 0 0 0 0 0 4.69722 5.62246 0 8.12304 0 0 0 0 0 A0A8P0PPR7 A0A8P0PPR7_CANLF "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752]; tricarboxylic acid cycle [GO:0006099] L-malate dehydrogenase activity [GO:0030060] EGVVECSFVKSPEA;GVVECSFVK 2 4.9 0.98419 -0.24386 0 0 0 0 8.26529 0 0 0 0 0 0 0 0 0 0 A0A8P0PPS6 A0A8P0PPS6_CANLF Forkhead box protein D1 FOXD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] AAAAAPLRLRALRLRLRPAAAA;DEDDDDDD;DEDDDDDDAPL;DVVGEGGDGGDDDEDGE;EDEDDDDDD;EDEDDDDDDAP;EDELEDEDDDDD;EDELEDEDDDDDDAP;EKFPAWQNSIRHNLS;VGEGGDGGDDDEDGEG 10 16.4 0.99136 -0.0026932 0 0 0 0 6.1607 4.89574 3.73183 6.19629 0 6.48465 0 0 0 4.61453 6.7922 A0A8P0PPV0 A0A8P0PPV0_CANLF Fer-1 like family member 5 FER1L5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] metal ion binding [GO:0046872] EEEGWEYGTFG;EGNNPTWNETLIWH;ERHAKQKGLPP;FKIIIAIIILFL;KVVIGGYQHNTR;KVYDCELEAVP;LLHTQGMVP;PVNIRPRKPRRYEL;RYHFKIIIAIIILFLALMLFN;SLDPTVIKFPARLIIQIWDN;YHYVPWYNSKPV;YLLHTQGMVPEHVE 12 7 1.0023 -1.2401 0 8.76964 0 0 0 4.97888 11.0274 7.52568 11.0544 9.16332 6.86369 0 0 7.25626 0 A0A8P0PPV7 A0A8P0PPV7_CANLF mitogen-activated protein kinase (EC 2.7.11.24) MAPK4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EQGTLTEEHAK;LFAGESLTVPSSFSSA 2 11 0.5445 0.42369 8.76431 8.14715 0 0 0 0 9.47458 9.64232 9.02456 0 0 0 0 0 0 A0A8P0PPW6 A0A8P0PPW6_CANLF Collagen type XIII alpha 1 chain COL13A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGPKGTKG;GEAGLDGAKGEKGA;PIGLPGFTGEKGE;PLGEDGLPVQ;PLGLPGTPG 5 6.8 1.0034 -2.2154 0 8.78947 0 0 0 0 0 8.24365 9.98812 0 0 0 0 8.1498 11.6043 A0A8P0PPX3 A0A8P0PPX3_CANLF Pleckstrin and Sec7 domain containing PSD Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085] EDEDEDEAGGEDDV;GKRGWKSFHGILKGMILYLQ;LSFMNWLPLPASV;PSLGSDNEDEDED;PWAPSSPTGQPPPGA;SGGSGSGS;TPEPGAAV;VGSGQGSGV 8 9.9 1.0024 -1.7956 7.76162 0 0 0 8.78388 0 3.62574 0 0 0 8.14246 9.84177 9.12469 0 0 A0A8P0PPX4 A0A8P0PPX4_CANLF RAB11 family interacting protein 3 RAB11FIP3 Canis lupus familiaris (Dog) (Canis familiaris) cleavage furrow [GO:0032154]; midbody [GO:0030496]; recycling endosome membrane [GO:0055038] calcium ion binding [GO:0005509] NGRRGPRGGGGGGV;WCPRPPSLSLCAASRTRPG;YSECETFTDEDTSTLVHPE 3 5.2 0.99452 -0.15282 0 0 0 6.35634 0 0 10.8285 0 0 8.1573 0 0 0 0 0 A0A8P0PPZ7 A0A8P0PPZ7_CANLF Intraflagellar transport 74 IFT74 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271]; intraciliary transport [GO:0042073] cilium [GO:0005929]; intraciliary transport particle B [GO:0030992] beta-tubulin binding [GO:0048487] NETHSQLTNLERKWQHHEQNNFV 1 4 0.98008 0.046263 0 0 0 0 0 0 0 9.47425 0 0 0 0 0 0 0 A0A8P0PPZ9 A0A8P0PPZ9_CANLF Coiled-coil domain containing 60 CCDC60 Canis lupus familiaris (Dog) (Canis familiaris) DIIQCKSGVCST;PRVFLKVLQDLRIWE 2 5.4 0.94071 0.10431 0 0 0 4.06411 0 0 0 0 5.4591 0 0 0 0 0 0 A0A8P0PQ07 A0A8P0PQ07_CANLF UPF3 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleic acid binding [GO:0003676] WREAEAHPALSSGGGV 1 15.4 0.95615 0.049233 0 0 0 0 0 7.58511 0 0 0 0 0 0 0 0 0 A0A8P0PQ16 A0A8P0PQ16_CANLF Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) DGKD Canis lupus familiaris (Dog) (Canis familiaris) glycerolipid metabolic process [GO:0046486]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205] ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; metal ion binding [GO:0046872] DQGGPHEED;FNNKRDEHPEKC;KTVQNREHFEPTQYSMDHFSGM;LASIGKDIIEDEDGVHTSCKESL;RKEMEEWIAALKTVQNR;TRDRAFENTL;VGSACPTR;VLGTKELL;VRAGMSGSLPGGS 9 10.1 0.99727 -3.6935 0 3.90246 8.21383 9.02309 9.59315 10.4118 9.93617 13.2081 0 0 0 0 8.87851 0 0 A0A8P0PQ22 A0A8P0PQ22_CANLF Cullin 4B CUL4B Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] EGQKLMQEREV;LLMFNEGEE 2 2.8 0.98723 -0.50211 0 0 0 0 0 0 0 11.7604 0 0 0 0 0 0 0 A0A8P0PQ34 A0A8P0PQ34_CANLF RGS domain-containing protein RGS5 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] cytoplasm [GO:0005737]; membrane [GO:0016020] SEDYKKIKSP 1 5.8 0.99942 -0.61146 0 0 0 0 0 0 0 9.20877 0 0 0 0 0 0 0 A0A8P0PQ37 A0A8P0PQ37_CANLF Voltage-dependent L-type calcium channel subunit beta-1 (Calcium channel voltage-dependent subunit beta 1) CACNB1 Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; voltage-gated calcium channel complex [GO:0005891] voltage-gated calcium channel activity [GO:0005245] DACEHLAEY;LAPIIVYIKI;QKTSMSRSPYP 3 5.3 1.002 -1.4751 0 0 0 0 4.085 0 0 0 0 0 0 0 7.71328 0 0 A0A8P0PQ53 A0A8P0PQ53_CANLF DENN domain containing 3 DENND3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DLWHLMVKEMWAGK;EDRYVLSGSGGGE;GKKLADDHKDPQYIQQALT;LDTYMFHAFL;LTVGHQKQIDP;PDDRVKNFEL;SKTRRRSFRKKRDKPKS 7 7.2 0.94173 0.059814 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.00641 A0A8P0PQ59 A0A8P0PQ59_CANLF Chitinase-3-like protein 1 CHI3L1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; carbohydrate metabolic process [GO:0005975]; inflammatory response [GO:0006954] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576] carbohydrate binding [GO:0030246]; chitin binding [GO:0008061] TIDSGYDVA;VIYSFANISNNEIDTWEWNDVTL 2 8.6 0.99739 -0.088467 0 0 0 0 0 4.92505 0 0 0 0 0 0 0 4.5152 0 A0A8P0PQ64 A0A8P0PQ64_CANLF G-protein coupled estrogen receptor 1 (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) GPER1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to estradiol stimulus [GO:0071392]; nervous system development [GO:0007399] axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; dendritic spine membrane [GO:0032591]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; recycling endosome [GO:0055037] G protein-coupled receptor activity [GO:0004930] ARLSCGLIWMASVS 1 3.6 0.93548 0.060932 0 0 0 0 0 0 0 0 2.88417 0 0 0 0 6.49916 0 A0A8P0PQ68 A0A8P0PQ68_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270] MWCSMIHKESVGDSFP 1 15.5 0.96147 0.049233 0 0 0 0 0 0 0 0 0 0 5.63157 0 0 0 0 A0A8P0PQ71 A0A8P0PQ71_CANLF Sialic acid acetylesterase SIAE Canis lupus familiaris (Dog) (Canis familiaris) sialate O-acetylesterase activity [GO:0001681] STLPAPPFIAFMTN;WNAMIHPLHN 2 5.1 0.98617 -0.41188 0 9.87191 0 0 0 0 0 0 0 0 0 10.1793 0 0 0 A0A8P0PQ76 A0A8P0PQ76_CANLF Ral guanine nucleotide dissociation stimulator like 1 RGL1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] ESPGPWLVE;KTWAAVPKDRMLMFEELSDIFSD;REPPHFPCLQ;SGSSGESMDSVSVSSCESN;TSITSTVLP;VEDHARIW 6 10 1.0029 -1.5154 0 6.70556 13.8948 9.0687 0 0 10.3789 0 0 0 0 0 8.31334 0 0 A0A8P0PQ92 A0A8P0PQ92_CANLF Ras-related protein Rab-3 RAB3C Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] NRGRCFCGVVDMVAGKL;STERGQHLGEQLGFEFFET 2 13.1 0.93777 0.10346 0 9.48214 0 0 0 0 0 0 0 0 0 7.76388 0 0 0 A0A8P0PQB1 A0A8P0PQB1_CANLF Cytochrome b reductase 1 CYBRD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] CFRKYPRPPECG 1 7.8 0.94763 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 8.83014 0 0 A0A8P0PQB4 A0A8P0PQB4_CANLF Potassium two pore domain channel subfamily K member 2 KCNK2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] VGSRASTRRAVEFT 1 7.2 0.94163 0.087553 0 0 0 0 0 0 12.8517 0 0 0 0 0 0 0 0 A0A8P0PQB8 A0A8P0PQB8_CANLF Myosin XVI MYO16 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DTLLGEKKQLSAEEKCRLVL;EFIEEMLL;FLKYWHANQLND;FSCAERAFHQLFQEQRPQCFI;HYCCFWPGPIFPHDPH;KYWHANQLNDMCLQLQRKIITCQ;YALEGTESSSILLTYLDEN 7 5.8 1.0027 -0.84172 0 9.3206 0 7.79416 0 0 7.12805 0 0 5.13836 0 0 0 14.6735 10.1816 A0A8P0PQC2 A0A8P0PQC2_CANLF BTB domain-containing protein KCNRG Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] KTECYSFERIKRPEV 1 5.5 0.95233 0.053874 0 0 0 8.40948 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PQE3 A0A8P0PQE3_CANLF Intraflagellar transport 80 IFT80 Canis lupus familiaris (Dog) (Canis familiaris) DAVRLCRFVKE;ILPKTLYERDASEFSK;PITSVAWAPD;QELVSCVGWT;SPKFPGMRTDILNAQ;TTAEELYSCSDDHQ;VVEQRWEWKNFQVT;WSKTGMLRSTLAQQ 8 13.3 0.98543 -0.42985 11.0329 7.33664 0 0 11.5671 0 12.6465 13.0256 11.9757 11.386 11.8119 4.41623 0 0 4.46819 A0A8P0PQF6 A0A8P0PQF6_CANLF MARVEL domain-containing protein CMTM4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ISGASSPYQP 1 5.6 0.99484 -0.18924 0 0 0 0 0 0 0 0 0 10.3619 0 0 0 0 0 A0A8P0PQH1 A0A8P0PQH1_CANLF Nudix hydrolase 16 NUDT16 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide metabolic process [GO:0009117] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] RNA binding [GO:0003723] LVEPGSLTAH;PSVTRRVRPAPG 2 4.5 0.99191 -0.54224 0 0 0 0 0 0 10.2688 0 11.8063 0 0 0 0 0 0 A0A8P0PQH6 A0A8P0PQH6_CANLF Basigin BSG Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; lateral plasma membrane [GO:0016328] D-mannose binding [GO:0005537] DTGSAPLAVGTSTTK 1 4.7 0.95016 0.053892 7.14119 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PQH7 A0A8P0PQH7_CANLF Zinc finger FYVE-type containing 28 ZFYVE28 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AEMIAHRT;EAAEEEPQCLS;EALRHFDVL;EVIVLFCETVERALDFGY;LAKGQEEARPVLEVLPS;PGVEGSPHREAS;RPFHTLLRKI;WPCLPAGCFPT 8 10.2 1.0029 -2.5186 0 0 9.27228 0 7.17333 8.16992 0 0 7.22439 4.26055 7.41447 0 0 0 9.51005 A0A8P0PQI1 A0A8P0PQI1_CANLF IKAROS family zinc finger 3 IKZF3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] PEPMGNAEEPEIP;TDDSMKVKDEYS 2 5.7 0.94485 0.05044 0 0 0 0 0 0 0 8.40429 0 0 0 0 0 0 0 A0A8P0PQI5 A0A8P0PQI5_CANLF Aminopeptidase (EC 3.4.11.-) LNPEP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] DLASRVVTRVFKLLRTQ;EHEMDEDEEDYE;LEYPFHEQI;MTCRGSVTISLQALQ;WNIILHSTGHNIS;YPFHEQIAI 6 7 1.0027 -1.1939 0 10.3115 0 0 4.31651 0 0 0 10.1195 0 0 12.6359 0 10.2653 0 A0A8P0PQK1 A0A8P0PQK1_CANLF Glutamate receptor interacting protein 1 GRIP1 Canis lupus familiaris (Dog) (Canis familiaris) DLETCGQSG;DLGDVEEDPSPAQKPGKLTD;GALHVGDHIL;PGPKAPPPNSPPALVS;PKKFPVSSHLSD;RDSSITSKVTLEIEFDVA;SIADRCGAL;SITSKVTL;TKPPDGALAVRRQS 9 9.4 1.0027 -1.4882 0 0 8.38608 9.96142 9.5167 0 7.85269 0 8.99769 0 10.8526 0 11.7305 11.6584 11.1935 A0A8P0PQK5 A0A8P0PQK5_CANLF Coatomer subunit beta (Beta-coat protein) COPB1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] COPI vesicle coat [GO:0030126]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] IVEKMLEVFHAI;KLSQKKESEKRNVTVQPDD;LEHRHSYVRR;TKKEEERPPLRGFLLD;VEELMEFL 5 7.2 1.0014 -0.91781 0 10.0947 0 0 0 0 0 8.81999 10.5163 0 4.65684 4.146 7.5245 0 4.06195 A0A8P0PQK9 A0A8P0PQK9_CANLF BTB domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CQEEQEEEAEEEEEEEEEEEE;EEDEEDEEDEEDEEEQVLLSEEHPG;EEEEEEEEEEQEEQ;EEEEEEQEEQEEEQ;EEQEEEEDEDEEEQEEEQKEEHKEE;EEQEEEQEEEQEEQEEEEDE;EEQEEQEEEQEEEQ;EQEHEEEQGDEEEEDEEDEE;EQGDEEEEDEEDEEDE;EQKEEQEHEEEQGDEEEEDE;QEEEAEEEEEEEEEEE;QEEQEEEEDEDEEE 12 28.1 0.68478 0.29016 0 0 5.09765 8.6471 5.94788 0 0 0 0 5.63796 0 0 0 6.66945 3.52682 A0A8P0PQN7 A0A8P0PQN7_CANLF LRAT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVARSDRVRPQPV;NREHFVNE;VGQELPYSLPCENREHFVN 3 21.4 1.0028 -1.3299 0 0 0 6.99039 0 0 0 5.9588 0 0 0 0 0 0 0 A0A8P0PQP2 A0A8P0PQP2_CANLF RanBP2-type domain-containing protein RYBP Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] metal ion binding [GO:0046872] KNVDRSTAQQLAV;PEKDKEIS;PLQIRPAAPLPAPP 3 5.8 0.93608 0.060949 0 0 0 0 0 0 10.0661 0 10.3627 0 0 0 0 10.6187 10.4766 A0A8P0PQQ7 A0A8P0PQQ7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) HUNK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DTWTRDLEFH;GGGGGGGA;GGGGGGGG;PAAPGGGG;PAPSSGGTQPL;PGGGGGGG;TPRIVKRPEPPVQGP;VLSNRACHI 8 8.6 1.0035 -1.0332 0 0 0 0 0 12.2265 0 0 8.24217 0 8.43784 0 0 0 0 A0A8P0PQR8 A0A8P0PQR8_CANLF Tudor domain containing 6 TDRD6 Canis lupus familiaris (Dog) (Canis familiaris) spermatogenesis [GO:0007283] AGEQVTDWRS;AGLVPAGGGG;DGPEYFWCQFADTEKLQ;DTEKLQYLEVE;EVPLYPDEESKE;GGGGGGGE;GGGGGGGG;GKNHDALQLHIS;KTLMCNIQ;LEVEVQTAGE;PSKFYNPDIDDI;QEAAATRGPGALGGASAAPGE;SEEESRDGKNHDA;VGLLWHRCR;VSFFKKTVLHKEIV;YLLPEYFRM 16 7.1 0.99937 -2.9219 10.9973 10.2496 11.6556 0 9.58444 0 10.097 6.62467 9.48806 10.4882 9.64886 9.68242 10.1984 8.93047 11.1602 A0A8P0PQR9 A0A8P0PQR9_CANLF Golgin A4 GOLGA4 Canis lupus familiaris (Dog) (Canis familiaris) EQMKIALEKSQSEYLKITQEKEQQ;EVLKARDKLE;FDPSSDMESEPEDSLPHLD;IVAIKKQLLSQMEEKE;KKEYEQEMEEKIKQ;LQQASAKLALFESQQSTT;NDKITIME;QIESLTEVH;RLEQEKEEM;RNGPMNVDLPKP;SEYTIFAL;TDKLKTTDEEFQSLRSSHE 12 7.2 1.003 -1.5123 6.77123 10.4065 12.9777 5.97868 8.84015 3.0994 6.56575 0 11.2047 9.76871 7.30779 11.6495 5.91145 9.73728 7.89881 A0A8P0PQS1 A0A8P0PQS1_CANLF DNL-type domain-containing protein DNLZ Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] GVFPGAGPG;PGCQKHHVIADNL 2 12 1.0036 -1.1093 0 0 0 0 0 0 0 0 0 8.10182 0 0 0 0 0 A0A8P0PQS2 A0A8P0PQS2_CANLF Proenkephalin-A PENK Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] chromaffin granule lumen [GO:0034466]; extracellular region [GO:0005576] opioid peptide activity [GO:0001515] ATVRAECGQDCATC;EESHALAK;GGFMKKMDELYPQE;VGRPEWWMDY;VPGFGAGG 5 12.7 0.99722 -3.4538 0 0 8.78578 0 0 0 0 0 0 6.27372 0 0 8.20741 0 0 A0A8P0PQU4 A0A8P0PQU4_CANLF Uncharacterized protein C4H5orf47 Canis lupus familiaris (Dog) (Canis familiaris) LPKKIVKSL 1 5.1 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0564 0 A0A8P0PQV0 A0A8P0PQV0_CANLF G-protein coupled receptors family 1 profile domain-containing protein NTSR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled neurotensin receptor activity [GO:0016492] IVAVYVICWMPYHVRR;RARRLLSPRRTRRLLSLVWA;VLSLALSALLLLLVCVPV 3 14.2 0.99401 -0.12063 4.95452 0 0 0 0 11.5059 0 3.73346 0 0 0 0 0 0 0 A0A8P0PQW0 A0A8P0PQW0_CANLF G kinase anchoring protein 1 GKAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] Golgi apparatus [GO:0005794] KLKNVITQW;VQKDSREENWQEWRQRDEQE 2 8.6 0.9476 0.050235 0 0 0 0 0 0 0 0 0 5.97398 0 0 0 0 0 A0A8P0PQX5 A0A8P0PQX5_CANLF CCHC-type domain-containing protein ZCCHC3 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218] double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GLGCPAGLAAPGLGDFPPAGRGDPK;GVGGGLGCPAGLAAPGLG 2 7.2 0.9882 -0.22401 0 0 0 0 7.94638 0 8.71555 0 0 0 0 0 0 0 0 A0A8P0PQX6 A0A8P0PQX6_CANLF Nectin cell adhesion molecule 1 NECTIN1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CEFATFPAGNRESQ;SSYEEEEEEE 2 4.8 1.0032 -0.86799 14.0555 0 0 0 0 0 0 0 0 0 0 0 6.66619 0 0 A0A8P0PQX8 A0A8P0PQX8_CANLF Paired box 6 PAX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" KKKKKKKK;KKKKKKKKKKK;LLEALQFCSCVLCCTTGMD;SKKKKKKKKK;SKKKKKKKKKK;SKKKKKKKKKKK 6 10.4 0.94887 0.04956 0 0 0 0 0 0 0 0 0 0 0 0 0 7.02658 0 A0A8P0PQY2 A0A8P0PQY2_CANLF Transmembrane protein 158 TMEM158 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PIESTLVACF 1 3.5 0.98867 -0.26253 0 9.84442 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PQY5 A0A8P0PQY5_CANLF Dedicator of cytokinesis 3 DOCK3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EASYYDNIMEQ;GKQISERF;MPVPHHFFLSL;PEKIERMCALFTDLSSKDMKRDLY;PKFLVKLES;QEQVHVLGVGLAVHEKFVHPEM;YPNPRYQGSVT 7 7.8 1.0044 -0.80421 0 0 0 3.88733 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PR02 A0A8P0PR02_CANLF Spliceosome-associated protein CWC15 homolog Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" spliceosomal complex [GO:0005681] DADDPLTDEEDEGEDFEEES;EDFEEESDDDDTSAL;EEDEGEDFEEESDDDDTS;PLTDEEDEGEDFEEES;TDEEDEGEDFEEESDDDDTSAL 5 12.2 0.9867 -0.38482 0 0 0 0 6.0058 5.6357 0 11.2295 0 5.00054 0 0 0 0 0 A0A8P0PR04 A0A8P0PR04_CANLF Histidine decarboxylase (EC 4.1.1.22) HDC Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520]; carboxylic acid metabolic process [GO:0019752]; catecholamine biosynthetic process [GO:0042423] carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] CFSEETPDVT;FTFNPSKWMMV;HGTEMAKY;LDPLDDDCFSEE 4 5.8 1.0033 -1.0356 6.97877 0 0 0 0 0 0 0 8.42857 0 0 0 5.32657 0 0 A0A8P0PR06 A0A8P0PR06_CANLF tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) TRMT6 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] GGSLQPKK;LPYHPFTLFP;LPYHPFTLFPRQDQS;RPSPSVQG;SVQGSSRSV 5 5.6 1.0023 -1.8617 0 12.8783 0 0 0 0 8.56091 10.2136 10.6955 0 0 0 0 0 14.0223 A0A8P0PR17 A0A8P0PR17_CANLF CD93 molecule CD93 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] AQLLQSEAGLEARNR;GVATCVQGSHQEDFECQC;LPLSPQPQAGSL;LVCSFNNGGCQQDCFEGGE 4 9.9 0.99339 -0.062868 0 0 6.7174 9.64272 10.7169 0 0 0 0 0 7.1632 0 10.685 0 0 A0A8P0PR29 A0A8P0PR29_CANLF Carnitine palmitoyltransferase 1C CPT1C Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] membrane [GO:0016020] acyltransferase activity [GO:0016746] GGGFGPAD;IFSGRKTM;KRCHLSSDSF 3 3.4 1.0041 -1.9792 8.98803 0 0 0 0 0 0 9.26376 0 0 0 0 0 0 8.44174 A0A8P0PR39 A0A8P0PR39_CANLF tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) TRMT5 TRM5 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] mitochondrial matrix [GO:0005759]; nucleus [GO:0005634] tRNA (guanine(37)-N1)-methyltransferase activity [GO:0052906] LHNCKLNKVDQKVKV;SILKQLNVN 2 4.9 0.99525 -0.56469 0 0 0 0 0 0 0 0 0 10.5051 0 0 0 0 0 A0A8P0PR45 A0A8P0PR45_CANLF Exonuclease 3'-5' domain containing 1 EXD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] LKKEEEEVTYTVIDQ;VYLFDIFLL 2 4.9 0.98462 -0.24172 0 9.74372 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PR47 A0A8P0PR47_CANLF Germinal center associated signaling and motility GCSAM Canis lupus familiaris (Dog) (Canis familiaris) regulation of B cell receptor signaling pathway [GO:0050855]; regulation of lymphocyte migration [GO:2000401] SEDLCYTLINHSVLGGK 1 10.6 0.98309 0.046227 9.57406 0 0 0 0 0 0 0 9.37047 0 0 0 0 8.92656 0 A0A8P0PR54 A0A8P0PR54_CANLF Low density lipoprotein receptor class A domain containing 1 LDLRAD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CSDWSDEYSCPGP;HGEDEDEAMCRDMPQSLP;LLLLVTLAALIALVTILGRPPRT;LSAFLLLLLVTLAALIAL;QRAEWRRAEQKP;TNNCGDCSDELSPV 6 28.4 0.65625 0.31377 0 0 4.56888 0 3.50067 5.70108 5.01574 6.13319 0 0 11.1453 0 0 0 0 A0A8P0PR57 A0A8P0PR57_CANLF Kelch like family member 26 KLHL26 Canis lupus familiaris (Dog) (Canis familiaris) FVYVAGGQHLQYRS;GGGFGAGP;HIIDFAYSAEVTLDLD;LMRSSDLVDSVQTLDIM 4 9 0.98987 -0.26592 10.829 0 0 0 0 0 0 0 0 0 8.83734 0 0 0 0 A0A8P0PR61 A0A8P0PR61_CANLF Kinesin associated protein 3 KIFAP3 Canis lupus familiaris (Dog) (Canis familiaris) kinesin complex [GO:0005871] kinesin binding [GO:0019894] DPMLGERKECQ;EFVIECLGTLANLTIP;GIIPALIELLN;KSSKPKDPPPFEGM;YGFRPDEPYYY 5 8.4 0.98632 -0.41808 0 0 0 0 0 0 0 0 0 0 9.22718 0 10.0688 0 0 A0A8P0PR63 A0A8P0PR63_CANLF Sodium channel and clathrin linker 1 SCLT1 Canis lupus familiaris (Dog) (Canis familiaris) clustering of voltage-gated sodium channels [GO:0045162] DLQLRLKTA;KQLHVTKE;LLEEANLQKNQVANTRKQYS 3 5.6 0.98176 -0.24931 0 0 0 0 0 0 0 0 0 0 0 9.66553 0 0 0 A0A8P0PR81 A0A8P0PR81_CANLF Kelch like family member 1 KLHL1 Canis lupus familiaris (Dog) (Canis familiaris) LFSHPSPAPGGPAGG;MILADLENHALFKNDLEC;STVGVAAL 3 6 1.0023 -0.66098 12.2856 12.1775 12.1329 9.70394 0 10.6881 12.3177 12.1687 12.3522 12.1224 0 12.3428 0 12.3394 12.2211 A0A8P0PR92 A0A8P0PR92_CANLF Solute carrier family 7 member 10 SLC7A10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ATGSVPRRW;LFTSSRLCF;LLVLRWRRPALHRP;NIIGSGIFISPKGVLEHSGSVG 4 9 1.0032 -1.5008 0 0 0 8.55896 0 0 0 0 0 6.893 0 0 0 9.3173 0 A0A8P0PR99 A0A8P0PR99_CANLF Fukutin FKTN Canis lupus familiaris (Dog) (Canis familiaris) FLIYSVHLVHLFTQ 1 18.7 0.93715 0.060955 0 0 0 0 0 0 6.60575 0 0 0 0 0 0 0 0 A0A8P0PRA0 A0A8P0PRA0_CANLF FACT complex subunit SUPT16H Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260] FACT complex [GO:0035101] AIPVASLDPIKEWLNSCDLKYTE;ATVLTSVKKKVKNVG;EALTKEELEFEVP;EDDYEEEEEDSDEDY;EDETFNPSEDDYEEEE;EEEEDSDEDYSSEAEES;EEEEKDEAEDL;EQKGEQQIQ;KRHTDVQFYTEVGEI;LTSVKKKVK;NPSEDDYEEEEEDSDEDYS;PFHIATIKNI;SVGVDEEI 13 12.8 0.99951 -2.9154 5.18686 11.057 7.78823 9.71884 3.36681 5.86854 0 8.32427 0 4.18737 0 0 3.419 5.74017 0 A0A8P0PRB3 A0A8P0PRB3_CANLF Potassium channel tetramerization domain containing 13 KCTD13 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] CLIPTVTSPRE;IFEETLNILIY;SPPTQWGFACAVSTRAAARPFP 3 9.5 0.97672 0.047261 0 0 0 0 0 0 7.88771 0 0 0 0 0 0 0 0 A0A8P0PRD8 A0A8P0PRD8_CANLF Regulator of G protein signaling like 1 RGSL1 Canis lupus familiaris (Dog) (Canis familiaris) FSTHLRTVTPI;IILKLFLHSEIPPRLRVNIS;KMLSSWYD;LDEEDYWFL;LVSSAHMLQVNRAYNE;SLFENIIKTFFHGKVSAEEI 6 8.2 1.0031 -1.7181 0 0 0 7.98851 0 0 8.22848 0 0 0 0 5.18781 8.09513 7.93623 9.29694 A0A8P0PRE4 A0A8P0PRE4_CANLF Translocation protein SEC63 homolog SEC63 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] KGPKKTAKSKKKKPLKK;KSKGPKKTAKSKKK;QEDSEGFEDSFEEEEEEEED;QEDSEGFEDSFEEEEEEEEDD;SEGFEDSFEEEEEEEEDDD;TVKKIVLL 6 6.7 1.003 -0.85261 5.99207 0 3.97737 0 4.51709 6.73985 0 0 8.47302 0 0 0 0 0 7.58886 A0A8P0PRF8 A0A8P0PRF8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] QFTQEKNFVD 1 6.8 0.99877 -0.61146 9.77429 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PRG0 A0A8P0PRG0_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC8 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139]; mitochondrial membrane [GO:0031966] palmitoyltransferase activity [GO:0016409] CSHCSVCDNCVEDFDHHCPWVN;NGSLSYDSLLNP;VQGSPRSHAECRRWP 3 6.4 0.98811 -0.47672 0 0 0 9.50335 0 0 0 0 0 0 0 0 0 0 4.22134 A0A8P0PRI5 A0A8P0PRI5_CANLF Nucleoside diphosphate kinase homolog 7 (NDK 7) NME7 Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] axonemal microtubule [GO:0005879]; nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleoside diphosphate kinase activity [GO:0004550] PDSFASAA;RPFLNELIQFITSGPTIAME;SAMQMFNMDRVNV 3 11 0.99023 -0.31396 0 0 0 0 9.44989 0 6.779 0 0 0 0 20.0235 0 0 20.0447 A0A8P0PRI7 A0A8P0PRI7_CANLF THAP-type domain-containing protein THAP2 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] RRKEWIRLLRRK 1 5.5 0.95351 0.05044 0 0 0 0 0 0 0 0 8.53508 0 0 0 0 0 0 A0A8P0PRJ3 A0A8P0PRJ3_CANLF F-box and WD repeat domain containing 10 FBXW10B Canis lupus familiaris (Dog) (Canis familiaris) AAYQNQETQQVQMEER;DGLVMAWSMVGKY;GVFWAASTRNTSFPLSRTL 3 4.6 0.98611 -0.42323 0 0 0 0 0 0 0 0 0 0 0 0 6.84937 0 11.2155 A0A8P0PRJ5 A0A8P0PRJ5_CANLF Autophagy related 2A ATG2A Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] AGLLTEAAPAAEQQT;GAEDLWLIE;IYPSEEGVTER;LDLADFQADVEL;PVLGYLPPTVITVLHT;SLVKMTLGGMTLTLLQTTAPS;TVITVLHTHL;VEHSSGDGE;VGLTSSVASALSELSLSDVDL;VGQGESALQHLICSQSSTKDGQSG;VTLNPQLSSAQWEVAPEKG 11 8.6 1.0017 -1.2113 7.90026 0 0 11.0912 10.2329 8.32057 0 0 9.46909 10.7908 0 0 8.84803 0 9.81786 A0A8P0PRK4 A0A8P0PRK4_CANLF Glutathione peroxidase GPX8 Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] membrane [GO:0016020] glutathione peroxidase activity [GO:0004602] EVIRPEIAALV;QLTDRNYLALQE 2 14.6 0.98636 -0.3223 0 0 0 0 13.159 0 0 0 0 0 0 0 0 0 0 A0A8P0PRK6 A0A8P0PRK6_CANLF Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) NUDT6 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; nucleus [GO:0005634] hydrolase activity [GO:0016787] YHKKLPDNYRTMTGMN 1 10.9 0.96139 0.049233 0 0 0 8.28748 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PRL0 A0A8P0PRL0_CANLF Zinc finger protein 800 ZNF800 Canis lupus familiaris (Dog) (Canis familiaris) HLPKRLIL;INVERHLPKRLILNIIRKLI;KRLILNIIRKLIRQMLPI;LPKRLILNIIRKLIRQ;NAINVERHLPKRLILNIIRKLI;PKRLILNIIRKLIRQ;PSDEQPQESQAD 7 16.6 1.0039 -0.80762 6.86456 4.49902 0 0 7.06221 0 5.35766 5.32117 4.39842 0 0 4.68891 6.04551 0 0 A0A8P0PRM7 A0A8P0PRM7_CANLF Translin (Component 3 of promoter of RISC) TSN Canis lupus familiaris (Dog) (Canis familiaris) RNA metabolic process [GO:0016070] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697] AGLFGCGA;HEHWRFVLQ 2 7.3 0.98956 -0.5297 0 0 0 0 0 8.80271 0 0 0 8.93044 0 0 0 0 0 A0A8P0PRM9 A0A8P0PRM9_CANLF Mitofusin 1 MFN1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fusion [GO:0008053] mitochondrial outer membrane [GO:0005741] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AIFDQLLEFVTEGS;LILHKDIWKKKLLDYPKK;LVDSPGTDVTTELDSW;SPGTDVTTEL 4 6.8 0.98622 -0.38933 0 0 10.6215 0 0 0 0 9.21755 0 0 12.1936 0 0 0 0 A0A8P0PRQ0 A0A8P0PRQ0_CANLF 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) PGLS Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] 6-phosphogluconolactonase activity [GO:0017057] MIGHFLGGDTEGAAL 1 6 0.94925 0.053911 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5152 A0A8P0PRQ2 A0A8P0PRQ2_CANLF Phospholipase (EC 3.1.4.4) PLD2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630] EDTEMEPSLMDGAEY;HHEKLLVVD;NIYEQIFRCL;TYRTLCRGEYSILHRLKAAMGT;VADAILQAQEEIFITDWWL;WDDLHYRLTD 6 9.5 1.003 -1.6646 0 0 0 0 3.22586 9.44259 0 0 0 8.14139 0 0 9.3726 0 0 A0A8P0PRQ3 A0A8P0PRQ3_CANLF Cardiomyopathy associated 5 CMYA5 Canis lupus familiaris (Dog) (Canis familiaris) ATGTTIAVYWSM;EDTGLYSPDVASVSEHSLPPST;EIQPYSVN;EPEDSNLVEEEIIEL;GDSVKSEASFPSRN;GPASLEGSEGDESEEESEEEE;GVLSRTQIF;ILHDTSVT;KDHEVATLDTAIS;LEYLEEKASFKTV;MEEPQDDQEVNGRI;NLDSNIVS;NVVRSVPEESNISLC;PEESNISLCPSLD;PFSLVKTVSVTEKSGTVLL;SEEEEEPDASLSDQDE;SEPPVLEEPRR;SSIDITKESMKQ;SVLPDSVDEPKKD;TASLEKMPAAFSLF;VYIGTVQYKIKM;YFEKYTLI 22 7.5 0.93595 0.074095 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.72226 A0A8P0PRQ7 A0A8P0PRQ7_CANLF Protein regulator of cytokinesis 1 PRC1 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule binding [GO:0008017] GSKAKVKKAL;PNRPGKVRKPIIT;YYDEDYTENLLQLH;YYDEDYTENLLQLHD 4 6.5 0.93926 0.059614 0 0 0 0 0 0 0 0 0 0 8.60028 0 0 8.51191 0 A0A8P0PRS3 A0A8P0PRS3_CANLF C2H2-type domain-containing protein ZNF529 Canis lupus familiaris (Dog) (Canis familiaris) CSECGKAFSQKSHHIRHQ;GKKPFKCNECGKAFSQKENLI;TEHEKIHIGEKPYK 3 12.9 0.99145 -0.13732 7.21927 0 0 0 0 0 10.0566 8.90225 0 0 0 0 0 0 0 A0A8P0PRS5 A0A8P0PRS5_CANLF Endothelial cell-specific chemotaxis regulator STING1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GEKDSITLISMKN;GVISFIVILVVVVIILVSVVSLRF;IVILVVVVIILVSVV 3 23.4 0.99026 -0.20188 0 0 0 0 0 0 0 0 4.23358 0 0 0 5.3168 0 0 A0A8P0PRS8 A0A8P0PRS8_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR132 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] MSTSNCNESFEDS;TDVSKLHT;VLATDHSRQEVSRIHKE;YYLRFALGFAVPL 4 13.5 1.0024 -1.0167 0 0 0 0 0 11.5332 0 0 0 0 0 10.2059 0 0 10.2674 A0A8P0PRU0 A0A8P0PRU0_CANLF Paternally expressed 3 PEG3 Canis lupus familiaris (Dog) (Canis familiaris) DRDRERRGRSRDLESRDRWPYT 1 33.3 0.98931 -0.26515 0 11.486 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PRU9 A0A8P0PRU9_CANLF Cationic amino acid transporter C-terminal domain-containing protein LOC119866298 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] DDEAGAQQEDVPA;LAAALPSVVAAVCH;PLLPLMSIFMNVYLMMQ;PLYFRVPAL 4 8.2 1.0025 -0.73927 0 10.1096 0 0 0 0 0 0 0 8.06985 0 0 0 0 8.2457 A0A8P0PRV8 A0A8P0PRV8_CANLF Keratin associated protein 16-1 KRTAP16-1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCCPSCCLR;DCCRPSCCCPSCC;ISSLCQPICSDCCRPSCCCPSC;PVCCEATICEPSCSVSSCC;SDCCRPSCCCPSCC;SGCSCESSSCGPQCC 6 27.3 0.85362 0.16703 5.13356 0 0 5.8874 0 0 0 0 0 0 0 0 0 0 4.63819 A0A8P0PRW5 A0A8P0PRW5_CANLF FAM86 N-terminal domain-containing protein EEF2KMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] cytoplasm [GO:0005737] methyltransferase activity [GO:0008168] DVLYCPETVL;ETVLSLVRVLQRLSACLKGQQAP;LCLLPQTVKHPLC;TSELGQAGIPWEAVPHHDQKLFP 4 19.8 1.0025 -0.72688 0 0 0 0 6.67723 0 0 0 9.52579 0 9.92236 0 0 0 0 A0A8P0PRY3 A0A8P0PRY3_CANLF Mucin like 3 MUCL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PANTTRALGGLKNP;TDHSHCDDSNGQ 2 3 0.91556 0.11122 0 9.27761 0 5.8844 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PRY4 A0A8P0PRY4_CANLF Neurofilament heavy chain NEFH Canis lupus familiaris (Dog) (Canis familiaris) axon development [GO:0061564] neurofilament [GO:0005883] structural molecule activity [GO:0005198] LARFAQEAEAARVEL;NRSLEGEAAALRQQ;SPEKAKSP 3 18.3 0.98954 -0.26298 0 9.24992 0 0 0 0 8.50402 0 0 0 0 0 0 0 0 A0A8P0PS06 A0A8P0PS06_CANLF SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 SMARCAD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] chromosome [GO:0005694] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ubiquitin binding [GO:0043130] DLSSDSEDIVSPNCSSTV;EPYEEDEFNDD;FGDAGGGP;KSADEQSIYEKERIAHA;LKVLCYYGSQ;LSEDLIWHC;MDGAIAAALLMF;VGSSLDEDYSSGEEVMEDGY;VLLKHHQHR 9 11 1.003 -1.1044 0 0 0 0 0 0 11.022 0 0 0 0 0 0 0 0 A0A8P0PS14 A0A8P0PS14_CANLF EH domain binding protein 1 like 1 EHBP1L1 Canis lupus familiaris (Dog) (Canis familiaris) AEIGGSEVPWFE;EWCQEVTAGYRGV;IDYASLDPLNI;PQVSRYKGAPPAADQGVMSRDLE;TLCEEDEE 5 4.7 1.0023 -0.76285 0 0 8.79662 12.483 9.10329 7.29774 0 0 0 8.41954 8.70151 8.46205 13.2728 10.919 12.9788 A0A8P0PS17 A0A8P0PS17_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC18 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] palmitoyltransferase activity [GO:0016409] AKPDASMVQSMLN;CVGRRNYRFFYAFI;DPDKLSHGDCAWS 3 8.4 0.92282 0.11945 0 0 0 0 0 0 0 0 8.64184 0 0 0 0 0 0 A0A8P0PS20 A0A8P0PS20_CANLF "Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9)" ACAT1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] "acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; metal ion binding [GO:0046872]" HLVHALKQGEYGL 1 4.2 0.98274 -0.25395 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82639 0 A0A8P0PS23 A0A8P0PS23_CANLF Synaptopodin 2 like SYNPO2L Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] APKTPPPMAPKTP;DEPIWRAELA;FGAAAGTGA;GALPDEVYLSDSP;GAPEPPAPSS;GELQVLSPLSPLSP;GVPPTSESELDEEAFS;KKRRQRAKKYT;TYTQKAKQAKL 9 11.4 1.0007 -2.7556 11.6769 10.381 0 0 0 0 11.2543 0 0 0 0 0 0 0 0 A0A8P0PS29 A0A8P0PS29_CANLF Zinc finger protein 71 ZNF71 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLETRVEMKQ;SSLTQHQRIHTGE 2 4.4 0.99505 -0.15782 0 0 0 0 0 8.86552 0 0 0 0 0 0 0 0 0 A0A8P0PS30 A0A8P0PS30_CANLF Tetraspanin TSPAN17 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLGGLDPV;LATGILAFVFKDWIRDQLNFFINNN 2 12.8 0.99003 -0.22223 9.45018 9.99845 0 0 8.32035 8.90632 6.66832 0 0 0 0 0 9.00518 0 0 A0A8P0PS45 A0A8P0PS45_CANLF KIAA0895 like MATCAP1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] HYLRGVNNARQPWHSAEGRLQ;VGEVVVQL;WPGHCGAQGLLMLR 3 7.9 1.0019 -0.99382 0 0 0 0 0 0 0 10.7361 0 0 0 5.74529 0 0 0 A0A8P0PS46 A0A8P0PS46_CANLF Armadillo repeat containing 2 ARMC2 Canis lupus familiaris (Dog) (Canis familiaris) FSEIKEQETFKGTISLPS;IVPILHELEKEENIE;LKLAKIILALK;LKLAKIILALKVSRKNLLNV;LVVRIVFILGNL;PVRPLPAPP;VLSLKLAKIILALKVSRK 7 8.1 1.0008 -0.63649 4.92253 0 9.03114 4.73888 0 0 3.97187 9.37184 0 0 13.7388 0 0 0 0 A0A8P0PS49 A0A8P0PS49_CANLF Plasmalemma vesicle associated protein PLVAP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EKQCQEQLKETNKSCNALFL;INASFRQCQADRV;VHVSTESNLQAT 3 10.2 0.99472 -0.12619 12.0654 0 0 0 0 0 5.66607 0 0 0 6.75782 0 0 0 0 A0A8P0PS60 A0A8P0PS60_CANLF Midkine (MK) MDK Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell division [GO:0051781] extracellular region [GO:0005576] growth factor activity [GO:0008083]; heparin binding [GO:0008201] GGRGGGGG;PCVLDKVKKGGPGSECAEWTWGPC;VGGGRGPDSSAPWPRG 3 7.6 0.9343 0.090535 0 0 9.08622 0 0 8.58725 0 5.18229 0 0 5.20057 0 0 0 0 A0A8P0PS68 A0A8P0PS68_CANLF Lysosomal phospholipase A and acyltransferase (EC 3.1.1.32) (EC 3.1.1.4) (EC 3.1.1.5) (1-O-acylceramide synthase) (LCAT-like lysophospholipase) (Lysophospholipase 3) (Lysosomal phospholipase A2) (Phospholipase A2 group XV) NFATC3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] hydrolase activity [GO:0016787]; O-acyltransferase activity [GO:0008374] IPSSIMHQPFQVTPTPP;QFPDGVDVRVPGFGKTFSLEFL;VLVAHSMGN 3 6.6 1.0037 -1.041 0 0 0 0 0 0 7.79058 0 0 0 0 0 0 0 11.6031 A0A8P0PS70 A0A8P0PS70_CANLF Armadillo repeat containing 4 LOC607539 Canis lupus familiaris (Dog) (Canis familiaris) AMFVESFIYKHPQEAKYVFVEPLEW;EIAMFVESFIYKHPQEAK;IALRSMKDFNL;LASSKNIL;NVVGALGECCQE;VFLNGGKTEDEGEI 6 7.6 0.98742 -0.26019 0 0 0 8.86879 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PS92 A0A8P0PS92_CANLF E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) RNF138 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; Wnt signaling pathway [GO:0016055] chromosome [GO:0005694] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transferase activity [GO:0016740] CPICVSLPWGD;LDLENIMRKFSGS;NTETYQENTSSGHPT 3 17 1.0029 -0.78688 0 0 0 0 0 0 0 0 0 0 0 10.1576 9.78996 0 0 A0A8P0PSA5 A0A8P0PSA5_CANLF Heat shock protein HSP 90-beta Canis lupus familiaris (Dog) (Canis familiaris) dynein axonemal particle [GO:0120293]; melanosome [GO:0042470] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] IEKEISDDEAEEEKGE;PYGWTANMERIMKAQ;VGSDEEDDNK;VPDEIPLLEGDEDA 4 12.4 1.0024 -0.71664 0 0 0 0 6.06626 10.0823 0 0 7.69467 0 0 0 7.04549 0 0 A0A8P0PSA6 A0A8P0PSA6_CANLF Protein phosphatase 1 regulatory subunit 16B PPP1R16B Canis lupus familiaris (Dog) (Canis familiaris) CNEDGLTALH;GTSVYYTVTS;QRSTAEDQRT;TYQYALSNGDVWKVHE 4 8.9 1.0022 -1.4438 0 0 9.14883 9.78633 0 0 0 4.03148 0 6.61381 0 0 10.4949 0 0 A0A8P0PSA9 A0A8P0PSA9_CANLF Complex 1 LYR protein domain-containing protein LYRM4 Canis lupus familiaris (Dog) (Canis familiaris) iron-sulfur cluster assembly [GO:0016226] NSKETSGSITGQQILGASPVT 1 16 0.99553 -0.015704 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.8749 A0A8P0PSB3 A0A8P0PSB3_CANLF Carboxylic ester hydrolase (EC 3.1.1.-) CES5A Canis lupus familiaris (Dog) (Canis familiaris) carboxylic ester hydrolase activity [GO:0052689] GPLRFKRPKPAL;GPLRFKRPKPALLW;GVVTARYHRDAGAPVYF;TAPPGPPV 4 7.1 0.98815 -0.49141 0 0 0 0 0 0 5.73863 0 0 9.96607 0 0 0 0 9.44845 A0A8P0PSE8 A0A8P0PSE8_CANLF High mobility group nucleosome-binding domain-containing protein 3 HMGN3 Canis lupus familiaris (Dog) (Canis familiaris) chromatin [GO:0000785]; nucleus [GO:0005634] nucleosomal DNA binding [GO:0031492] SENGETKAEEVLSI 1 8.2 0.94342 0.061104 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.43087 A0A8P0PSF3 A0A8P0PSF3_CANLF BTB domain containing 6 BTBD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GGGPGRPT;IHIPDVEP;RPPRPHAAAPGLPARPGGAVPHG;RRRRRRRHGHRQQQRQRRRRRRRRQ;RSNQWRYRGRCDSIQ 5 8.4 0.97399 0.035538 0 0 0 0 5.3488 0 0 0 0 0 0 0 0 0 0 A0A8P0PSH3 A0A8P0PSH3_CANLF "Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1)" STAR Canis lupus familiaris (Dog) (Canis familiaris) steroid biosynthetic process [GO:0006694] mitochondrion [GO:0005739] cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020] VLQKIGKDTVITHELAAESA 1 7.5 0.98259 -0.24853 0 0 0 0 0 0 0 0 0 0 0 0 0 9.27903 0 A0A8P0PSH8 A0A8P0PSH8_CANLF 60S ribosomal protein L32 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ALRPLVKLKIIKK;ALRPLVKLKIIKKRTK;IIKKRTKKFI;LRPLVKLKIIKKRTKK;LRPLVKLKIIKKRTKKFIRHQ;LVKLKIIKKRTKKF;LVKLKIIKKRTKKFIR;LVKLKIIKKRTKKFIRHQ;PLVKLKIIKKRTKK;PLVKLKIIKKRTKKFIR;RPLVKLKIIKKRTKKFIR;RPLVKLKIIKKRTKKFIRHQ;VKLKIIKKRTKKFIRHQ 13 25.9 0.99096 0.0017922 2.83082 6.7366 5.48614 5.54003 0 4.25972 3.43309 0 6.06117 6.31712 0 0 10.5088 0 8.00759 A0A8P0PSI1 A0A8P0PSI1_CANLF HORMA domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KGWLYKCSVQ;VISNIESDEVLERW 2 23.3 1.0042 -0.8172 0 8.77627 0 0 0 10.7399 0 0 0 0 0 0 0 8.86186 0 A0A8P0PSK5 A0A8P0PSK5_CANLF Secretin SCT Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179] PPLLLLLL;SEPAIPAAQVT 2 14.2 0.98387 0.035491 0 0 0 0 0 0 0 8.33539 0 0 0 0 0 0 0 A0A8P0PSK6 A0A8P0PSK6_CANLF Proteasome subunit beta type-4 PSMB4 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] nucleus [GO:0005634]; proteasome core complex [GO:0005839] VSLVLLLKFQ 1 3 0.99914 -0.61146 0 0 0 0 0 0 0 5.43349 0 0 0 0 0 0 0 A0A8P0PSL2 A0A8P0PSL2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGIWGKVSLDNYFSL;VSLDNYFSLLNEKATNV 2 19.5 0.93891 0.10012 0 0 0 0 0 0 0 0 0 0 0 8.99093 0 0 5.49602 A0A8P0PSM4 A0A8P0PSM4_CANLF Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) CPSF2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398] mRNA cleavage and polyadenylation specificity factor complex [GO:0005847] RNA binding [GO:0003723] DSFNATYVQP;EQSKEPEDFLVPELQATE;GHQSVFMNEPRLSDFKQVLLREGIQ;RGDGNVLI;VLLREGIQ 5 8.5 1.003 -2.1901 0 10.6624 0 8.83257 0 6.91779 0 0 0 0 9.68226 0 0 9.03452 0 A0A8P0PSN2 A0A8P0PSN2_CANLF 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Translation inhibitor L-PSP ribonuclease) RIDA Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisome [GO:0005777] RNA binding [GO:0003723] RRPGEKASAGPGLR 1 4.3 0.9347 0.060855 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5396 A0A8P0PSP0 A0A8P0PSP0_CANLF Semaphorin 6A SEMA6A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] AAPGSTAKMLIKAD;EAGSCAHLSP;GMLDWKDLLDSP;MPPMGSPVIPTDLPLRA;TPESTPTL;TQSKDPKPEAILTPLMHN;VDMDTSHTEEIYC 7 9.4 0.98563 -0.44241 10.5854 0 0 0 0 0 0 0 8.74494 9.4038 8.93958 0 3.62328 4.38846 0 A0A8P0PSQ2 A0A8P0PSQ2_CANLF General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3) GTF2H3 Canis lupus familiaris (Dog) (Canis familiaris) nucleotide-excision repair [GO:0006289]; regulation of DNA-templated transcription [GO:0006355] transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675] metal ion binding [GO:0046872] KAKKKKLK;LIDACVLDSD;NKEVKDNQEMK;PVLKAKKKKL;PVLKAKKKKLK;PVLKAKKKKLKV;VLKAKKKKLK;VLKAKKKKLKV;VLKAKKKKLKVS 9 11.9 0.99918 -3.1125 3.91054 0 0 0 9.72656 0 0 3.89714 0 4.89898 9.30465 0 3.81445 0 0 A0A8P0PSQ5 A0A8P0PSQ5_CANLF Insulin like growth factor 2 mRNA binding protein 3 IGF2BP3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA transport [GO:0051028]; regulation of translation [GO:0006417] cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; P-body [GO:0000932] RNA binding [GO:0003723] AEKSITILST;QDTDTKITIS 2 3.7 1.0006 -0.92893 0 0 0 0 0 0 0 0 9.58342 0 0 0 0 0 0 A0A8P0PSU2 A0A8P0PSU2_CANLF Uncharacterized protein BCAS4 Canis lupus familiaris (Dog) (Canis familiaris) SACPGGVGV;VGPGQTPG;YFGGDLATRRNGA 3 14.7 0.98788 -0.46903 0 0 0 0 0 7.83504 0 0 0 0 5.89246 10.4826 0 0 0 A0A8P0PSW9 A0A8P0PSW9_CANLF Ribosomal protein S6 kinase (EC 2.7.11.1) RPS6KA2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; ribosomal protein S6 kinase activity [GO:0004711] EEGKWDSTSPETKPAAPAE;GVPPSANA;ILARIGSGKYAL;TIEYMAPEVVNRR 4 6.9 0.95284 0.052429 0 0 0 10.2435 0 0 0 0 0 0 0 0 0 0 0 A0A8P0PT42 A0A8P0PT42_CANLF FHA domain-containing protein CEP170B Canis lupus familiaris (Dog) (Canis familiaris) EDPAAKAAAAVVAG;GVLRCLEGCRPRPS;PGAGTQEGKPALTPPSPQG;PGSPVAPSREGEERVGAPGVSV;TGGSSGPQ 5 4.9 1.0024 -1.8562 10.006 0 11.242 0 0 0 0 0 9.7038 0 0 0 0 0 0 A0A8P0S5Z6 A0A8P0S5Z6_CANLF Coiled-coil domain containing 102B CCDC102B Canis lupus familiaris (Dog) (Canis familiaris) IKEESKSPNNKDRLIYQ;LGGQREEE;TENCTLKS;WDKREMLETEKQGLE 4 10.8 1.0042 -2.0196 9.7909 0 0 8.76742 8.32405 0 12.3351 0 0 0 0 0 11.6876 0 0 A0A8P0S648 A0A8P0S648_CANLF DCC netrin 1 receptor DCC Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KNSNLLVIIVITIGVITVLVV;TASLGLAGKARSPL;TLEPNNLWYLFT 3 3.2 0.97333 0.047166 0 0 0 0 0 4.47748 0 0 0 0 0 0 0 0 0 A0A8P0S663 A0A8P0S663_CANLF DNA polymerase iota POLI Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887] EVQKELLADWKRAGSD;GKPLGVQQKYL;GVLSFFSTK;TNWDFLPSGRIE 4 7.1 1.0018 -1.2074 0 0 0 9.97212 6.7862 0 0 7.64184 0 0 0 0 7.39403 0 0 A0A8P0S684 A0A8P0S684_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) TRIM36 PGGT1B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] zinc ion binding [GO:0008270] CMDCSASYCNE;GSPGRWRSRWSPGG;KSCMDCSASYCNEC;RGDGGAAP;RRHWLFSFPSR 5 4.4 1.0018 -0.91172 9.1431 9.10145 0 0 0 0 0 0 0 0 0 0 0 8.06803 0 A0A8P0S693 A0A8P0S693_CANLF Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) PIP4K2C Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol metabolic process [GO:0046488] endoplasmic reticulum [GO:0005783] ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742] AAPGFGFASKTKK;KHGAGAEISTVHPEQYAKRFLDF 2 8.7 0.92864 0.10602 10.1585 0 0 0 0 7.58571 0 10.4718 0 0 0 0 0 0 0 A0A8P0S6A4 A0A8P0S6A4_CANLF NHS like 1 NHSL1 Canis lupus familiaris (Dog) (Canis familiaris) DNFKALLLK;ELRHFENVI;GFRQPCNKEEGGR;LCDDYQDEDEETDQ;PNVYSLCGATP;QEGSRTQVPGG;SPLCDDYQDEDEETDQKCSVSS;SRKPPPISKKPKLFLVVPPPQRDLT;SSCPACCN;TDTLVRRPKKVKRRKT;VISPACVVSPHA 11 8.7 1.004 -1.1044 5.09001 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S6E7 A0A8P0S6E7_CANLF TNF receptor superfamily member 11a TNFRSF11A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] MFSEDMCCPDSGG;PDSGGGCG;PDSGGGCGG;PQCAYGMGLPPEG;QEQGQAQAQAQAQAEA;SEDMCCPDSGGGCGGACAGG 6 8.6 0.99331 -0.076258 0 0 0 0 0 0 0 0 10.644 0 0 0 0 0 0 A0A8P0S6F1 A0A8P0S6F1_CANLF Serine hydroxymethyltransferase (EC 2.1.2.1) SHMT2 Canis lupus familiaris (Dog) (Canis familiaris) glycine biosynthetic process from serine [GO:0019264]; tetrahydrofolate interconversion [GO:0035999] glycine hydroxymethyltransferase activity [GO:0004372]; pyridoxal phosphate binding [GO:0030170] ALEAFDLDPAQWGVNVQ;EIELLCQR;EVVDEIELLCQRRALEAFDLDP;GREIPYTFEDRINFAVFPSLQGGPH;TREVASRGWTGQES 5 13.7 1.0017 -0.91423 0 5.15656 0 6.94369 6.31301 8.10318 0 0 0 0 0 0 9.83468 7.20994 8.68138 A0A8P0S6F8 A0A8P0S6F8_CANLF Mediator of DNA damage checkpoint protein 1 MDC1 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694] DSEEEVDSPSER;DTDVEEERIPAT;EDCGTDVEEDTSL;EPHSTIPTDQPLC;EVTQETVFL;MPQPIEPTAPDL;SVAEASHLVTDRVR;VGRMPDCSVTLPFSSISKQHAV;VLRPPKVL;VLTTPEFQPSVPTD 10 6.7 1.003 -2.161 0 0 0 9.7896 9.53644 9.73278 0 8.36567 9.82963 3.18924 4.00809 12.92 0 0 0 A0A8P0S6G6 A0A8P0S6G6_CANLF Matrilin 2 MATN2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AGELPKRVHQPTES;AVGDHGCE;CQCFEGYILREDG;DQTTCRTVDYCASENHGCEHE;EQDHGCEQLCLNTEDSYVCQCS;GDHGCEHSCVSSGDS;KQADLVFIIDSSRSVNTHD;LVLGQILLVLPA;MTQRMEALENR;NLANEEVRKLTQR;NSYICKCS;RDLLSCSN;VDYCASENHGCEHECVNADSSY 13 18.1 0.99951 -2.9136 14.1252 0 0 6.84624 12.2915 12.719 9.81203 14.0937 6.72028 0 4.26146 9.57249 0 0 4.76017 A0A8P0S6H7 A0A8P0S6H7_CANLF Nuclear envelope integral membrane protein 1 NEMP1 Canis lupus familiaris (Dog) (Canis familiaris) nuclear inner membrane [GO:0005637] LFFMYSGIQ;LMGLFFMY 2 2.7 1.0017 -0.69341 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.132 A0A8P0S6K4 A0A8P0S6K4_CANLF Grainyhead like transcription factor 2 GRHL2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] PRGDGEEQRVVIF;QMYYNTDDER;SDSQEEQDKRNCLGTSEAQG;SEKYGLPVEKITKL;VVFSEDKNRDEQ;WDVNEEAKPSAD 6 12.8 1.0023 -0.66701 0 9.57147 0 0 3.69343 0 8.78584 0 0 0 8.77334 7.86456 0 0 6.68159 A0A8P0S6K7 A0A8P0S6K7_CANLF Solute carrier family 26 member 10 SLC26A10 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transmembrane transport [GO:0098661] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] SGAAAWGL 1 1.5 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 8.07911 0 A0A8P0S6L5 A0A8P0S6L5_CANLF Ribonuclease P/MRP subunit p21 RPP21 Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] endoribonuclease complex [GO:1902555]; ribonucleoprotein complex [GO:1990904] metal ion binding [GO:0046872] GRRHSISMAEGGSRVQE;KPNLRKGPWTW 2 10.2 0.94973 0.081718 0 0 10.2428 0 0 6.19176 0 0 0 0 0 0 0 0 0 A0A8P0S6M3 A0A8P0S6M3_CANLF AT-rich interaction domain 1B ARID1B Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] brahma complex [GO:0035060]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677] AAGGGGGG;CVDEEDEEDE;DEEDEEDEDEDEEDSGKPE;DEEDEEDEDEDEEDSGKPET;DLSGSIDDLPTG;EDEEDEDEDEEDS;ELLVEYFRKCL;ERPSSLPDLSGSI;GGGAAQPG;GGGGAASL;GGGGDGGG;GGGGGGGA;GGGGGGGG;GGGGGGSG;GPSQPCGA;LVLILGKLILL;NVGTSSSA;PGQGPPSGQPPYGGHQP;QVTGPPPQPPPIRREITFP;QYLPSQSQQRY;TECVDEEDEEDEDEDEEDSGKPET;VDEEDEEDEDEDEEDS;VGEAPAAA;VPGGGGGP;YYNQQPQPPHLPPQAQ 25 9.6 0.98982 -0.26592 0 0 0 0 0 0 0 0 0 0 0 9.61714 0 0 0 A0A8P0S6P3 A0A8P0S6P3_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] DCEYSQISTHS;GIAAYGATQSQSDMCDQDQC;MCDQDQCIQSTKFVLQAAATPL;NGTSSGGY;RRGYIQPDTPQPATPSNGIA 5 14.5 1.0018 -1.2559 0 6.20916 0 0 0 0 6.62113 0 0 0 6.90953 0 0 8.05066 0 A0A8P0S6Q2 A0A8P0S6Q2_CANLF Tubulin tyrosine ligase like 8 TTLL8 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] cytoplasm [GO:0005737] AADHLPAKDNKWVV;ATVLQGARFV;FDIRQWFLVTDWNPLTIWFYKESYL;VVVDRKVDRNCDIGNFE 4 8.7 0.99343 -0.16283 0 0 0 8.44344 0 0 9.6561 0 0 0 6.54822 8.15714 0 0 0 A0A8P0S6Q6 A0A8P0S6Q6_CANLF Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) SRFBP1 Canis lupus familiaris (Dog) (Canis familiaris) ELQEEEKEYFDD;EVKRIRVLVIRKLVRSVGRLKSK;KRIRVLVIRKLVRSVGRLKS;MKELKPDIVTKSALGDDINFE;NEVVKMRKEVKRIRVLVIRKL;SVELRKFESI 6 17.3 0.97676 0.047166 0 0 0 0 0 5.83173 0 0 0 0 0 0 0 0 0 A0A8P0S6Q7 A0A8P0S6Q7_CANLF Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) ATAT1 MEC17 Canis lupus familiaris (Dog) (Canis familiaris) neuron development [GO:0048666]; regulation of microtubule cytoskeleton organization [GO:0070507] axon [GO:0030424]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; microtubule [GO:0005874]; spindle [GO:0005819] tubulin N-acetyltransferase activity [GO:0019799] NIGHQESKQGEQETEN;TSARLAGK 2 5.8 1.0026 -1.3749 0 0 0 0 0 0 0 0 0 0 0 0 6.52004 0 0 A0A8P0S6Q8 A0A8P0S6Q8_CANLF Receptor-binding cancer antigen expressed on SiSo cells EBAG9 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] Golgi membrane [GO:0000139] IRKTQKIKKREPLN 1 6.6 0.93403 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.86592 A0A8P0S6U4 A0A8P0S6U4_CANLF Collagen triple helix repeat containing 1 CTHRC1 Canis lupus familiaris (Dog) (Canis familiaris) LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLQ;LLLLLLLLLLQLRAP;PPRLQGLLLLLLLLLLQL 6 8.5 0.97368 0.048313 0 5.15838 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S6U8 A0A8P0S6U8_CANLF Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase) ACSL6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] ATP binding [GO:0005524]; long-chain fatty acid-CoA ligase activity [GO:0004467] DELFFNKIQ;DIRLLSDDM;DIRLLSDDMKALCP;DVEELNYWTCKGEGEICVRGP;FLKVTEKVIFPRQDDVL;IENIYIRSE;KDPDRTKEALDSDGWLHTGDIGKWL 7 13.4 1.0036 -2.2411 0 0 9.10685 0 9.36737 0 10.9058 0 0 5.15117 10.9015 11.0787 0 0 11.1296 A0A8P0S6V0 A0A8P0S6V0_CANLF Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) SRFBP1 Canis lupus familiaris (Dog) (Canis familiaris) AEGLVVKMRKEVKRIRVLVIRKLVR;ELQEEEKEYFDD;EVKRIRVLVIRKLVRSVGRLKSK;GLVVKMRKEVKRIRVLVIRKLVRS;KRIRVLVIRKLVRSVGRLKS;MKELKPDIVTKSALGDDINFE;SVELRKFESI 7 17.8 0.98775 -0.34838 0 0 9.08228 0 0 0 0 7.64422 0 5.92244 0 9.22615 13.6014 0 0 A0A8P0S6W5 A0A8P0S6W5_CANLF Malonyl-CoA-acyl carrier protein transacylase MCAT Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] transferase activity [GO:0016740] AMQAASEAVPSGML 1 3.6 0.94718 0.079901 0 0 0 11.5767 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S6X2 A0A8P0S6X2_CANLF Dimethylarginine dimethylaminohydrolase 2 DDAH2 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] AGSSDAAQ 1 2.8 1.0042 -1.1044 8.69912 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S6X7 A0A8P0S6X7_CANLF "Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Globotriaosylceramide synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)" A4GALT Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] FSALPPGNIFF 1 3.1 0.98498 -0.2453 0 0 0 0 0 0 0 10.5104 0 0 10.0418 9.86785 10.6091 0 0 A0A8P0S6Z5 A0A8P0S6Z5_CANLF WBP2 N-terminal like WBP2NL Canis lupus familiaris (Dog) (Canis familiaris) transcription coactivator activity [GO:0003713] VGYGPSQAGYGPSQGG 1 6.6 0.98696 -0.23038 0 0 0 0 0 0 0 0 0 0 14.1129 0 0 0 0 A0A8P0S711 A0A8P0S711_CANLF C-X-C motif chemokine ligand 14 CXCL14 Canis lupus familiaris (Dog) (Canis familiaris) CICPDITTSEL;PFLCKKKKNKKKKKKK 2 21.1 0.98938 -0.19673 0 0 11.6114 0 0 0 0 0 0 0 0 0 3.45641 0 0 A0A8P0S717 A0A8P0S717_CANLF Neurogenin 1 NEUROG1 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] DFAYGPGDPLFSFPGLPKDLLHTT 1 9.8 0.9719 0.041303 8.2329 0 0 0 0 0 0 0 9.65571 0 0 0 0 0 0 A0A8P0S727 A0A8P0S727_CANLF Transmembrane protein 71 TMEM71 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TDVNTSSNFACDFL 1 5 0.98439 -0.24351 0 0 0 0 9.60361 0 0 0 0 0 0 0 0 0 0 A0A8P0S743 A0A8P0S743_CANLF Chromosome 14 C1orf35 homolog C14H1orf35 Canis lupus familiaris (Dog) (Canis familiaris) KKKKKKRKKKHKKEKKK;RKEKKKKKKRKKKHKKEKK;RKSRKEKKKKKKRKKKH;RKSRKEKKKKKKRKKKHKKEK;SHRKSRKEKKKKKKRKKK;TDKQRENY 6 9.8 1.0034 -0.86705 6.50838 0 6.52887 2.76503 0 0 0 0 0 0 0 3.47573 0 7.55781 7.08226 A0A8P0S757 A0A8P0S757_CANLF RUN and TBC1 domain-containing protein 3 SGSM3 Canis lupus familiaris (Dog) (Canis familiaris) LTAFASVVHVRLLLRLWD 1 2.4 0.95398 0.051986 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.58241 A0A8P0S769 A0A8P0S769_CANLF ENTH domain containing 1 ENTHD1 Canis lupus familiaris (Dog) (Canis familiaris) AGPSFWTLSHPQ;HLMSMSGN;KLLKVARLHNKKN 3 5.5 1.0025 -0.71654 0 0 0 0 0 0 10.1227 0 0 0 3.83915 0 0 0 0 A0A8P0S772 A0A8P0S772_CANLF Lysine-specific demethylase (EC 1.14.11.65) KDM3B Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] AAAGGDPGPALRT;GHNHRTHILHQSSSH;KANCPCISRQN;QEIFSRGPY;SELKAIRP;TDTQKEVKEMVMGLNV;TEERPTVGPG;VGKRLLLL;VGKRLLLLFA;VLASSGFGAPL 10 5.8 0.95303 0.053886 0 0 0 0 0 0 0 0 0 0 0 0 0 8.67634 0 A0A8P0S792 A0A8P0S792_CANLF TPD52 like 3 TPD52L3 Canis lupus familiaris (Dog) (Canis familiaris) RQNPSKSWHNVQVSDVYMKQKTP 1 18.9 0.97931 0.046276 7.64017 0 0 0 2.50266 0 0 0 0 0 0 0 0 0 0 A0A8P0S7A0 A0A8P0S7A0_CANLF Zinc finger CCCH-type containing 3 ZC3H3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AAAGGKAQ;GRLDPTTSCSRSLASRAV;RGASLCLPQPLVPGDKEAPP;RRALSPRAASENMCKAPFGTEE;VRQARQRRRKQRQEYCMYYNRF 5 7.6 0.98661 -0.35891 6.59157 0 0 9.31655 9.62361 9.03067 0 10.2494 0 9.55288 0 0 11.979 0 7.78692 A0A8P0S7B0 A0A8P0S7B0_CANLF Trafficking protein particle complex subunit 9 TRAPPC9 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794] KGTHRGWAAVQ;KLDVHWRII;VGPFALTVAP;YHMSVELLRS 4 4.8 1.0039 -0.80421 0 4.97145 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S7B7 A0A8P0S7B7_CANLF Thioredoxin domain containing 15 TXNDC15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLFYTPWCRF 1 2.9 0.98922 -0.26294 0 0 0 0 0 9.78952 0 0 0 0 0 0 0 0 0 A0A8P0S7B8 A0A8P0S7B8_CANLF BCL2 interacting protein 5 BNIP5 Canis lupus familiaris (Dog) (Canis familiaris) CSKEADRG;DLLQEVDGQ;PDEVFESKEMIIQR 3 4.7 1.0027 -1.1937 8.35248 7.84518 0 0 0 0 0 0 0 0 10.9151 7.53924 0 0 0 A0A8P0S7D4 A0A8P0S7D4_CANLF Mesoderm specific transcript MEST Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] catalytic activity [GO:0003824] DKPRPHHYSIFE;RRDRLRREWWVQVGLLAVP;VGLLAVPLLAAYLHI 3 11.7 0.98511 -0.44719 0 0 0 0 0 0 5.44622 11.025 0 0 0 0 0 9.17193 0 A0A8P0S7D8 A0A8P0S7D8_CANLF L3MBTL histone methyl-lysine binding protein 3 L3MBTL3 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] zinc ion binding [GO:0008270] DADCPDIH;DEQIDGEAFLLMT;DQKEERDIGE;ENCCQYGNVDECLSGGNYCSQ;KAQAAPKSLFENQNIT;NSLPAPARAFKVKPPH;NWDESYDYWCEASSPHIH;QSVYCVLTVAE;VLKQGVPPKGKKAW 9 16.8 0.94202 0.060267 0 0 0 0 0 0 0 0 0 0 6.07515 0 0 0 0 A0A8P0S7G9 A0A8P0S7G9_CANLF Nuclear factor 1 NFIB Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DENMEPSP;ILPPAPSSYF;ILPPAPSSYFSHPT;NSPAAGSRTWHER;PITTSTEGEAAS 5 7.9 1.0034 -1.55 0 11.0895 0 0 0 0 0 0 5.90289 0 9.33112 0 0 0 0 A0A8P0S7H8 A0A8P0S7H8_CANLF BHLH domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] GPKGATQDQLGGQGAGRPQ;SPLGSSGTRGP 2 7.1 0.99349 -0.17604 0 0 0 0 8.68138 0 0 0 10.2138 0 0 0 0 0 0 A0A8P0S7I4 A0A8P0S7I4_CANLF Thioredoxin 2 TXN2 Canis lupus familiaris (Dog) (Canis familiaris) protein-disulfide reductase activity [GO:0015035] HSGPARAPARAAA 1 2.9 0.94088 0.059851 0 0 4.02919 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S7L0 A0A8P0S7L0_CANLF Cyclin dependent kinase inhibitor 2B CDKN2B Canis lupus familiaris (Dog) (Canis familiaris) GGGGDGGG;GGGGGDGG;GGGGGGDGGG;TESGSHARTEG 4 11.9 0.80576 0.20797 0 9.77235 0 0 0 0 0 0 0 0 0 0 9.88815 0 0 A0A8P0S7L2 A0A8P0S7L2_CANLF Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; postsynaptic membrane [GO:0045211] acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888] AGVPLLPPLLL;GVPLLPPLLLLLVLLP;MRVPAQKIWKPDIVL;PLLLLLVLL;RRAGVPLLPPLLLLL 5 7.3 1.001 -0.92201 3.6133 0 0 0 0 0 10.3658 0 0 0 0 4.84664 0 0 5.96885 A0A8P0S7M3 A0A8P0S7M3_CANLF Staphylococcal nuclease domain-containing protein (EC 3.1.31.1) SND1 Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047] melanosome [GO:0042470]; nucleus [GO:0005634]; RISC complex [GO:0016442] nucleic acid binding [GO:0003676]; RNA endonuclease activity [GO:0004521] ATRREGMRANNPEQNRL;GEFCIAKFVDGEWYRARVEKVESPA;IENKTPQGRE;QVLNADAIVVKL;YPPTFLLLQCPTF 5 8.2 1.0029 -0.73104 8.05452 9.61278 0 0 0 0 0 6.64674 0 0 0 0 0 0 0 A0A8P0S7N7 A0A8P0S7N7_CANLF RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) RTCB Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" cytoplasm [GO:0005737]; tRNA-splicing ligase complex [GO:0072669] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; RNA ligase (GTP) activity [GO:0170057] AAAGNYAWVNRS;ISKKAIKLRPIAVIK;ISKKAIKLRPIAVIKG;VEGVFYVNDALEKL 4 8.5 0.99327 -0.0080486 0 9.87788 0 8.73562 0 5.74357 0 0 0 2.82487 0 0 0 0 0 A0A8P0S7P2 A0A8P0S7P2_CANLF "TLE family member 4, transcriptional corepressor" TLE4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355]; Wnt signaling pathway [GO:0016055] nucleus [GO:0005634] DALIGPGIPRHARQINTLNHGE;DISHPGNKSP;DSKVCFSCCSDGNIA;IVPHAGMNGEL;PGIPRHARQINTLNHG;PTPFGIVPHAGM;VVGFDPHHHMRVP 7 11.1 1.0021 -1.217 0 0 6.48227 9.17595 10.1601 0 9.50781 0 0 0 4.38211 0 0 9.88325 0 A0A8P0S7P8 A0A8P0S7P8_CANLF MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase MFNG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] glycosyltransferase activity [GO:0016757] LGVQADGQMNP 1 3.1 0.98477 0.035491 0 0 0 0 0 0 0 0 0 6.75181 0 0 0 0 0 A0A8P0S7Q4 A0A8P0S7Q4_CANLF KLF transcription factor 9 KLF9 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] AKGKHASE;GVAAKGKH;HTEFHPSMIKRSK;PPACGCSG 4 10 0.99899 -3.2535 0 0 0 0 0 0 9.08813 0 8.22689 0 0 0 9.46999 10.6677 0 A0A8P0S7R7 A0A8P0S7R7_CANLF Zinc finger protein 804B ZNF804B Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] QSSQTNTFALSVDP;SVERHDGRHQKHSCLCLSEEM;YSKHRYGRCRERSKL 3 4.2 1.0013 -0.64232 0 0 0 0 0 0 0 9.14144 8.94202 0 15.8866 0 0 0 0 A0A8P0S7R9 A0A8P0S7R9_CANLF STEAP2 metalloreductase STEAP2 Canis lupus familiaris (Dog) (Canis familiaris) iron ion transport [GO:0006826] endosome membrane [GO:0010008] GGGGGGGA;GGGGGGGG;IVILGKIVLLLPCISRKLKRI;LALVLPSIVILGKIVLLLP;LVLPSIVILGKIVLLLP;PGGGGGGG;PSIVILGKIVLL;PWLETWLQCRKQL 8 7.2 0.73112 0.25296 0 6.42279 5.0778 0 0 0 0 0 9.45383 0 0 0 4.3075 0 0 A0A8P0S7W4 A0A8P0S7W4_CANLF Spermatosis associated serine rich 1 SPATS1 Canis lupus familiaris (Dog) (Canis familiaris) VHLDLAADLDLKSSSH 1 5.4 0.98241 -0.25039 0 0 0 0 0 8.88777 0 0 0 0 0 0 0 0 0 A0A8P0S7Z1 A0A8P0S7Z1_CANLF Frizzled-1 FZD1 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DYFLLLLLLLLL;GGGHRGGG;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLL;LLLLLLLLLLLL;LLLLLLLLLLLLPG;LLLLLLLLLLLP;LLLLLLLLP;LLLLLLLP;RSLCERARQGCEA;YHFLGEKDCGAPCEP 13 8.4 0.99652 -0.57443 0 10.4211 9.03103 9.10358 9.05926 10.1861 0 0 0 0 0 0 0 5.50503 8.29287 A0A8P0S7Z3 A0A8P0S7Z3_CANLF TNF receptor superfamily member 21 TNFRSF21 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; signal transduction [GO:0007165] membrane [GO:0016020] ESEPLLRCDSTS;HPEHMESHEVPSSTYVPKG;ISALRQHRRNDV;LSPSPIPSPN;PIFDDMLHILNPEEL;RLDPCDLQPI 6 11.8 1.003 -1.5346 6.38289 0 12.2551 0 0 0 6.2128 0 7.0607 0 7.15178 0 0 13.32 0 A0A8P0S806 A0A8P0S806_CANLF Chromosome 1 C9orf85 homolog C1H9orf85 Canis lupus familiaris (Dog) (Canis familiaris) KTENPEINLHSNH 1 8.4 0.94641 0.061211 0 0 0 0 0 0 0 8.98596 0 0 0 0 0 0 0 A0A8P0S811 A0A8P0S811_CANLF Aminoadipate-semialdehyde dehydrogenase AASDH Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] nucleotide binding [GO:0000166] LVVIPAVDESSATVYIGSHS;SPVVWESMLIIGCRNNYV;SSPCTSASEQE 3 4.9 0.98934 -0.20289 0 0 0 0 0 6.71094 0 0 0 0 0 0 7.7494 6.26763 5.99027 A0A8P0S812 A0A8P0S812_CANLF Paraoxonase (EC 3.1.1.2) PON1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] arylesterase activity [GO:0004064]; metal ion binding [GO:0046872] PHGISTFTDEDNT;VGCHPNGIRIFF 2 7 0.98932 -0.20231 0 7.62863 0 0 0 0 0 0 0 0 0 0 9.94778 0 0 A0A8P0S839 A0A8P0S839_CANLF AF4/FMR2 C-terminal homology domain-containing protein AFF3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DGQQRATQQGSLRTLLGDGV;LDLLMGPVTLH;RQKLVFDDMPRS;SESSSGSDSETESSSSESEGSK;VEFQSSASRCRS;VGVPKPGV;VNPHKPPILIQNES 7 7.9 1.0018 -1.4288 7.16501 6.70224 0 0 8.6436 0 11.1161 0 0 0 10.9827 11.7988 2.65613 0 0 A0A8P0S840 A0A8P0S840_CANLF Tyrosine-protein kinase (EC 2.7.10.2) TXK Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] DEYISSSGAKFPIKWSPPEV;GVCIQQKPLYIV;IFCCCCCC;SEKYTPHRRLWFRE;TIQSIFCCCCCCS;VTENKLTNLEIYEWY 6 13.4 1.0029 -0.86959 8.33025 0 0 0 0 0 7.7077 0 0 0 0 5.93286 8.54932 9.37645 0 A0A8P0S856 A0A8P0S856_CANLF Osteomodulin OMD Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ECFCPPNFPSSMY 1 3.1 0.99169 -0.27713 0 0 0 0 0 0 0 0 8.93531 0 0 0 0 0 0 A0A8P0S870 A0A8P0S870_CANLF Muscular LMNA interacting protein MLIP Canis lupus familiaris (Dog) (Canis familiaris) ANLSSPSSTVSESQLTKPG;KHEKGSLLNKNLEEKLTSESNE;LSQACSLSPT 3 5.5 0.98332 -0.25548 0 0 0 0 0 9.17774 0 0 0 0 0 0 0 0 0 A0A8P0S874 A0A8P0S874_CANLF FERM and PDZ domain containing 1 FRMPD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] ANHPCQKTEFSESPT;ANTTVKDIILTVKEK;ESEKVSMVKVYLQ;FEDGSSDEEYYDA;LDLLKEDPVAFEYLYLQSCSDVLQ;LTVKEKLSIRSMEY;SGASSMTDSA 7 6.2 1.001 -0.9457 0 0 8.57917 0 0 0 0 3.02297 0 7.63981 0 12.0067 9.53284 0 0 A0A8P0S875 A0A8P0S875_CANLF Regulatory factor X8 RFX8 Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700] EVTVFVKRLRRKTYLSN;FLNCLYSNLQ;IEDILLHDFLE;LPSTPSSSVDL;VLQPSRNK 5 12.4 0.98602 -0.41328 0 0 9.90694 0 0 0 11.3079 0 10.3607 0 0 10.6463 0 3.53618 0 A0A8P0S878 A0A8P0S878_CANLF Sulfotransferase (EC 2.8.2.-) SULT1C2 Canis lupus familiaris (Dog) (Canis familiaris) sulfation [GO:0051923] lysosome [GO:0005764] aryl sulfotransferase activity [GO:0004062] HVKGWWEIKDRYQI;QETSFEKMKENPMVNRSTVP;SLQDSMALATALEAQLQ 3 13.9 0.97547 0.04609 0 0 0 0 0 7.63096 0 0 0 0 0 0 0 7.15856 0 A0A8P0S881 A0A8P0S881_CANLF VPS50 subunit of EARP/GARPII complex VPS50 Canis lupus familiaris (Dog) (Canis familiaris) "endocytic recycling [GO:0032456]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; EARP complex [GO:1990745] ETYIKAYYLTENDMERWIKEHR;HCIRLANRTIVEGYANVK;LCSGNTDTKFQ;QEEFRELREQPSDPQAEQELIN;SNFSILQLHEFKFME;SQHNIYVDAL 6 10.4 0.97435 0.046883 0 0 0 0 0 0 0 0 9.66406 0 0 0 0 0 0 A0A8P0S883 A0A8P0S883_CANLF eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) BZW2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GLNEAGDDLEAVAKF;NHCVFSANEDHET;TLPATILT 3 8.6 1.0017 -1.3147 0 0 0 0 0 8.96316 8.95881 0 0 0 0 0 0 7.66135 0 A0A8P0S887 A0A8P0S887_CANLF Family with sequence similarity 178 member B FAM178B Canis lupus familiaris (Dog) (Canis familiaris) EMLPLWEE;NIQEWPGKLQQL;PAIALDISLSYI 3 9 1.0031 -0.78262 0 0 0 0 10.1475 0 0 0 0 0 0 0 0 12.7412 0 A0A8P0S8C7 A0A8P0S8C7_CANLF Family with sequence similarity 135 member A FAM135A Canis lupus familiaris (Dog) (Canis familiaris) DKYETEESSIAG;EITLEKEALQEA;EQGQGDEEEEQDQQMVQN;GYNFDLKTYIRQTSQKEAS;HASLVALHQ;LHHAYHFH;SFPRPVKTTWL;YFSMEEEDSSEDGV 8 6.9 1.0031 -2.3198 12.4295 13.4198 13.4982 0 11.5848 12.0386 0 0 0 12.3459 5.50357 12.6592 12.0783 0 0 A0A8P0S8D3 A0A8P0S8D3_CANLF Semaphorin 4D SEMA4D Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; signal transduction [GO:0007165] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] DTMASRVPTDREDSQR;EVQLEKFH;TVEQSHTKWVRYNGA 3 4.6 0.9556 0.049233 0 0 0 0 0 0 0 9.90143 0 0 0 0 0 0 0 A0A8P0S8E1 A0A8P0S8E1_CANLF HIVEP zinc finger 3 HIVEP3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AGPQPPDA;DEDEDEDEEESQDEPS;DEDEDEDEEESQDEPSGPA;DEEESQDEPSGPASEAP;DLDEDEDEDEEESQD;DSDSDLDEDEDEDEEESQDEPSGP;DSDSDSDLDEDEDEDEEESQ;EDEDEEESQDEPSGPAS;EDSDSDSDLDEDEDEDEE;EEPTEGES;FEEPTEGESTDSED;GEPRTSRGSPEPSG;LSPGSKGSTES;PYPGSSTAATQEGPLQELLAPQP;QQVSPPNTNARSYAEI;SASFERDDHGKAEA;SSPQRHSPAGGPQA;STKAALSLLRSKQ;TTLSQILV;VLDAERLAAGSCSTSSQ 20 7.7 0.99698 -3.6403 0 8.19111 6.85275 0 0 4.47236 0 6.6522 10.12 10.0646 7.12443 8.95521 6.30071 5.43846 8.42777 A0A8P0S8F2 A0A8P0S8F2_CANLF Paired box 2 PAX2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677] AEYKRQNPTMFAWEIRDR;DTFTQQQLEALDRVFERPSYPDVF 2 9.2 0.97369 0.041303 0 0 0 0 8.5155 0 0 0 0 0 0 0 0 0 0 A0A8P0S8G4 A0A8P0S8G4_CANLF Leukocyte immunoglobulin-like receptor subfamily B member 3 LOC484306 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TGVLGKPSLLT 1 2.3 0.98176 -0.2495 0 0 0 0 0 0 0 0 0 0 0 0 13.4855 0 0 A0A8P0S8H2 A0A8P0S8H2_CANLF Endoplasmic reticulum lectin ERLEC1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503] endoplasmic reticulum lumen [GO:0005788] carbohydrate binding [GO:0030246] IEAEVTTCEYE;NKEEELQSTKEERFPA;VILTPLLCNHPKYRFRA 3 9.7 0.99165 -0.066253 0 12.4735 12.2739 9.7682 0 0 0 0 10.2483 6.1031 0 10.4706 10.5357 11.0555 0 A0A8P0S8M6 A0A8P0S8M6_CANLF PrdX deacylase domain-containing protein 1 LOC100856725 Canis lupus familiaris (Dog) (Canis familiaris) aminoacyl-tRNA editing activity [GO:0002161] VGSGNLRFADETAML 1 9 0.94887 0.053911 0 0 0 7.33825 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S8N3 A0A8P0S8N3_CANLF Friend virus susceptibility 1 LOC484356 Canis lupus familiaris (Dog) (Canis familiaris) HPAYMLGEE 1 3.1 0.99133 0.0036507 0 0 0 0 0 0 0 0 0 9.84648 0 0 0 0 0 A0A8P0S8P8 A0A8P0S8P8_CANLF G-rich RNA sequence binding factor 1 GRSF1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EAVDFGATSSLHF;GVSGRRRLLLLLGAAA;LPKEMSEKLPEA;NEKDIVDFFAGL;NFFAPLKPVRITMEY;TGAACLPFY 6 15.6 1.0031 -1.4988 0 0 0 0 0 4.58358 0 8.67578 0 0 8.35063 0 9.83167 0 0 A0A8P0S8R3 A0A8P0S8R3_CANLF tRNA pseudouridine(55) synthase (EC 5.4.99.25) PUS10 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] DLQLVTREAIGH;EDVDVRTLGNG;EVSVVFAHPETVEDC;HGAVFVAG;LAVFKAESFNFS 5 10.9 1.0034 -1.639 0 0 10.5417 0 0 0 0 12.0192 10.5179 0 0 0 0 9.7105 8.12371 A0A8P0S8R7 A0A8P0S8R7_CANLF Actin-like protein 7A ACTL7A Canis lupus familiaris (Dog) (Canis familiaris) single fertilization [GO:0007338] cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634] FEYEEHGPFFLYRRC;LCSEMFFKPSLI;PIYEGYPLPSI;PTHNISSTVGKPYMET;SLKDGPAK 5 14.3 1.0034 -0.89002 11.8488 12.0259 11.8011 0 2.25981 9.51321 0 0 0 0 0 0 9.86804 10.9325 0 A0A8P0S8R8 A0A8P0S8R8_CANLF BCL11 transcription factor A BCL11A Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] EDDEEEEEEEEEEEEELTESERVD;EEEEDDEEEEEEEEEEEEELTESER;ENGDEEEEEDDEEEEEEE;ENGDEEEEEDDEEEEEEEEEEEEE;FSEAFHQVLGE;NGDEEEEEDDEEEEE;PENGDEEEEED;PENGDEEEEEDD;PENGDEEEEEDDEEEEE;QPFTSAWFLLQHAQN;SENDPGLIPENGDEEEEEDD 11 8.7 0.99757 -0.090669 0 0 0 8.06086 6.08217 0 0 5.13976 0 0 5.27531 0 12.2341 0 5.41606 A0A8P0S8V0 A0A8P0S8V0_CANLF Growth hormone releasing hormone receptor GHRHR Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] IIRILLRKLEPA;NIIRILLRKLEPAQGSLHT;RWHGHNPEL;VGVAAAAA 4 7.7 0.98949 -0.20335 0 0 0 0 0 4.5287 0 0 0 5.33892 0 0 0 0 0 A0A8P0S8V7 A0A8P0S8V7_CANLF Polypyrimidine tract binding protein 3 PTBP3 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] RNA binding [GO:0003723] NYYTPVTPHLRSQPVFIQYSNHR 1 5 0.97422 0.046615 0 0 0 0 0 8.4607 0 0 0 0 0 0 9.37725 0 0 A0A8P0S8V8 A0A8P0S8V8_CANLF Receptor activity-modifying protein 3 RAMP3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; regulation of G protein-coupled receptor signaling pathway [GO:0008277] plasma membrane [GO:0005886] coreceptor activity [GO:0015026] ARRRPQLRLLLLLLL;DECIQRLTIPQKSTGYVW;EDPPDECI;LLLLCGGC;LLLLLLLCGGCPRVGGCN;LLLLLLLL;RLLLLLLL;RLLLLLLLL;RRRPQLRLLLLLL;RRRPQLRLLLLLLLL 10 34.5 1.0036 -1.0561 6.68342 0 0 0 0 0 0 0 0 0 0 0 8.91436 0 0 A0A8P0S8W8 A0A8P0S8W8_CANLF AGBL carboxypeptidase 3 AGBL3 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosol [GO:0005829] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] DLYGVSSSG;LSLLKAPKKKRK;SQIKNKKKYLK 3 3.2 0.99673 -0.096444 0 5.40677 9.92487 0 10.2624 10.1675 10.3224 10.273 0 10.6969 0 10.6783 0 0 0 A0A8P0S8W9 A0A8P0S8W9_CANLF Cell cycle regulator of NHEJ CYREN Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033] SPDQDEDEDM 1 6.8 0.99942 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 6.75328 0 0 A0A8P0S8X3 A0A8P0S8X3_CANLF Microtubule actin crosslinking factor 1 MACF1 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] CTSMPSSP;EEIESHATDVHQAVK;EEQEEEDDDDVPRE;ESGQPVQCESDVI;GADLIFAC;GHNLTPEERQVLQDKLGE;IETLTARDEHQAGPPEMFEVGHQRL;IVKDYELQLMTYKA;LAASGGQSPTGEQIPQFQQRQK;LDSSYLPS;LKETSSFR;LSQSEAKNP;LVDNLRSVCIPDVM;LVDWLYKVE;MTTAAEEGEA;MVRVGGGWMALDEFLVKNDPCR;NSEEQEEEDDDD;PHMQLADSSERS;PLSIDPNMLT;PSEMLQEATL;PSEQKPMNTSEKS;QKFLQDHQEFENWLERSERELENM;QQHEQLNEAAQGILTGPGD;SFMGLLWPESGEILPITDGL;SIDIIRHKDS;SLEEMTQRLKEFQESFKNI;TLEQARQLATKFQSTY;TNSEEQEEEDDDDV;VKDYELQLMTYKAFVE;WETYEELSPWI 30 5.1 0.99663 -4.8842 9.32305 9.95182 11.3185 10.7024 5.31549 10.5136 8.58233 10.5765 11.9761 8.57478 0 6.84046 0 8.68909 11.7825 A0A8P0S8X4 A0A8P0S8X4_CANLF BTB domain and CNC homolog 2 BACH2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] NLEDSCFSFLQ;VGLPAAAG 2 2.3 1.0028 -1.3528 0 0 0 0 0 0 0 0 13.9261 0 8.05853 0 0 0 0 A0A8P0S8X5 A0A8P0S8X5_CANLF Amelotin AMTN Canis lupus familiaris (Dog) (Canis familiaris) odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of enamel mineralization [GO:0070175] DLQLLNPAAGMASGTQTL;LPAQLNPALGLP;MASGTQTLPLSL 3 16.1 0.9461 0.084539 9.97943 0 11.2784 0 0 0 0 0 0 9.25673 14.913 0 0 0 0 A0A8P0S8X6 A0A8P0S8X6_CANLF CCR4-NOT transcription complex subunit 4 CNOT4 Canis lupus familiaris (Dog) (Canis familiaris) CCR4-NOT complex [GO:0030014] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842] KHQEYEQKLLQ;QICRFCWHRIRTDENGL 2 4.9 0.98786 -0.49414 0 0 0 0 0 0 0 8.78989 0 0 0 0 0 0 0 A0A8P0S8Y7 A0A8P0S8Y7_CANLF Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) YRDC Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] double-stranded RNA binding [GO:0003725]; transferase activity [GO:0016740] GGGGGGGE;LPQHLLAGGDGVQEL;MKGGGGGG 3 4.9 0.95368 0.053902 0 9.12735 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S907 A0A8P0S907_CANLF 40S ribosomal protein S25 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] IYPRNTKGGAAPAA;KWSKGKVRDK 2 17.6 0.98317 -0.25383 0 0 0 8.45504 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S918 A0A8P0S918_CANLF Adenylyl cyclase-associated protein 1 CAP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton organization [GO:0007010] plasma membrane [GO:0005886] actin binding [GO:0003779] CEIVSAKSS;PGPPPPPVPTSSG;SIQALGWVAMAPKPG 3 8.1 0.99742 -0.097284 0 0 0 0 0 0 0 11.7565 0 0 0 0 0 0 0 A0A8P0S921 A0A8P0S921_CANLF ATP binding cassette subfamily A member 4 ABCA4 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; visual perception [GO:0007601] plasma membrane [GO:0005886] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CRCSTREKLTM;FEADPQLRDWSV;GVVFPDMYPWTSA;IPMMYPAS;LSDLLCGYPEG;LVLLDEPTTGMDP;PIFMVLAWIYSV;QVRPEQFAHGVPDLM;RKRQKIRFVVELVWPLS;SLSQGTLQWV;SLYADRLVGTYSG;STFEELERLRKLVKAW;TDRTLRLT;TEPITEEMEDPEHPEGI;VNELMDMVQHHVPEAKLVECIGQ 15 8.6 1.0023 -2.5918 9.63599 10.529 4.61606 10.6138 7.79188 0 11.1003 8.59242 10.5919 0 9.51088 11.0513 12.11 7.66903 0 A0A8P0S928 A0A8P0S928_CANLF Trafficking protein particle complex subunit 12 TRAPPC12 Canis lupus familiaris (Dog) (Canis familiaris) ESQMVKSP;HESVLFNLTTMYEL;HPEGPGCAPPARQSP;HYLHESVLFNLTTMYELESSRS 4 5.7 1.0011 -0.93513 0 0 0 0 0 0 0 0 9.11197 0 9.36556 0 9.96018 0 7.05028 A0A8P0S929 A0A8P0S929_CANLF Forkhead box protein P2 FOXP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] DEVEYQKRRSQKITG;LDHIDSNGNSSP;QESATETISNSS;SSDRQLTLNEIYSWFTRTFAYFR 4 9 0.98752 -0.46486 8.62578 0 0 6.72615 7.7496 0 0 0 0 0 0 0 0 0 0 A0A8P0S930 A0A8P0S930_CANLF Secernin 1 SCRN1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805] ETVGKYWAAEQITEGVKCICNQL 1 6.1 0.97741 0.046343 0 0 7.39515 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S931 A0A8P0S931_CANLF Doublecortin domain containing 2C DCDC2C Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] EDNERKMAWEWIPI 1 3.9 0.93502 0.060932 10.1152 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S956 A0A8P0S956_CANLF Leucine rich repeat neuronal 3 LRRN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] STISPGAF;YLQKPTFTFS 2 2.5 1.0027 -1.3529 0 0 8.27729 0 0 0 0 8.17008 0 9.11048 0 0 8.56007 8.45746 7.93115 A0A8P0S960 A0A8P0S960_CANLF LanC like glutathione S-transferase 2 LANCL2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179] membrane [GO:0016020] LVHWCHGAP;VGGFDSLSFRIVQNFTKRIQTKI;VRSLYPATFEYSR 3 9.2 0.91676 0.11721 0 0 5.37125 0 0 0 0 6.98071 0 0 0 0 0 0 0 A0A8P0S973 A0A8P0S973_CANLF C-type lectin domain family 4 member F CLEC4F Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GRSPAFWGSHQ;NWQHEDGRTEDCVHMQHKWNDMLCD 2 5.8 0.9392 0.071029 0 0 0 0 0 0 0 5.87344 2.92174 0 0 0 9.37827 0 0 A0A8P0S9A4 A0A8P0S9A4_CANLF MATH domain-containing protein PHF19 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872]; methylated histone binding [GO:0035064] AAKAYVPLRAKRR;DRICPKCQGDDPQSGS;DSPHRTNQQQCYCYCGGP;QCYRCRQWFHEACTQ 4 6.7 0.96363 0.049233 7.91415 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S9A7 A0A8P0S9A7_CANLF Collagen type XXVII alpha 1 chain COL27A1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix structural constituent [GO:0005201] AGPTPFPLLMGPP;GDDGDPGP;GSLGPTGAPGRMG;GVSGDPGFQGD;KGSMGHPG;LDVHDGRWHH;PGLDGNPG;PVPARTGTHRSPQ;SITAPVRPLRKSTATKI;VGVDNLPPAS 10 6 0.99855 -3.0128 0 0 11.5793 0 6.97338 0 0 11.5917 11.8509 0 12.9599 2.53254 10.3044 6.14301 13.7919 A0A8P0S9B4 A0A8P0S9B4_CANLF Olfactory receptor OR9A4 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FLGHLSALEI;VPVMLWELL 2 6.1 0.99685 -0.59012 0 0 0 0 0 0 0 0 0 0 0 0 11.6746 0 0 A0A8P0S9C8 A0A8P0S9C8_CANLF Mastermind like transcriptional coactivator 3 LOC119863905 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription of Notch receptor target [GO:0007221] nuclear speck [GO:0016607] transcription coactivator activity [GO:0003713] GASPAGPG;KKSGAGAG;LNDQEWQELIDEL;QHNILTYGNTKPLT;SGPVAVAG;TVAGSASGPVAVAGSDMSPAE;VPSGGFGP 7 6.6 0.99723 -3.7872 8.52423 0 0 0 0 9.97585 0 0 12.7892 11.6242 11.2786 0 0 0 0 A0A8P0S9D7 A0A8P0S9D7_CANLF WD repeat domain 35 WDR35 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] AAKLMFKI;DTGMYVVSIQWN;GRERIYHIDDTPSG;KRTKPLRVKKLY;TKADENHPQFVLVLCNSI 5 5.9 0.98695 -0.39652 0 0 0 12.0787 3.59789 0 0 0 0 0 0 0 0 7.22342 2.91414 A0A8P0S9H4 A0A8P0S9H4_CANLF Apolipoprotein B APOB Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] chylomicron [GO:0042627]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; low-density lipoprotein particle [GO:0034362]; very-low-density lipoprotein particle [GO:0034361] lipid transporter activity [GO:0005319] AEYKEDNRYRGLQDW;ASYYPLSRDTRFEL;DQIIEKLKIL;DVVTYLVALTP;EALDVRVLLDKLRITIPFQRIK;EPSAERLQEI;FSGSNTLHLVSTTKT;IIPRLKLSDLN;IKVSPGEFTITL;KIEEEIQRLKEKKFSYLINH;KLVQLAHQYKLK;LAPADLFEIGLE;LESGHITWTSSGLG;LVQNQLQEASQQLQQLH;LVYTKNPKGYHF;PEARAYLHILG;PSLLIQKAAIQALRK;SKPTVSSSIELIYDL;SLDGKATLTEVSLGSAYQ;TKDGKREQDMVNGI;VAKPSVSME;VGLAFEST;VIQFDQYI;YIKDLKKLV 24 7.1 0.99718 -3.9783 0 9.99901 8.73843 0 4.04273 11.6904 9.00627 10.7029 6.36931 6.71631 7.72629 10.166 8.52462 6.15648 7.90989 A0A8P0S9H5 A0A8P0S9H5_CANLF Transcription factor BTF3 BTF3L4 Canis lupus familiaris (Dog) (Canis familiaris) DEEDDDVPDLVENFDEA;HFNNPKVQ;LSANTFAIT 3 34 1.003 -1.6321 0 0 0 0 0 0 0 0 0 0 0 6.22689 0 0 0 A0A8P0S9J0 A0A8P0S9J0_CANLF Carbonic anhydrase-related protein 11 (CA-RP XI) CA11 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] GNRDPRHPERRCRGPNYR;LSGNGRPLQ;SELRLLFGARDGAGSEHQINHQ 3 15 0.99247 -0.16895 0 0 0 0 0 0 0 10.2757 0 0 0 0 0 0 0 A0A8P0S9K0 A0A8P0S9K0_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase makorin-1) MKRN1 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] DDDLTDSEDEWDLFHDEL;DLTDSEDEWDLFHDELEDFY;GAAAAAAAASPTPIPTV;GAGGGGGG;GGGGGGGG;LAAGGDDD;VTSPSSGAGGGGGGGGGGGGGG 7 13.7 0.98647 -0.38841 0 0 11.2912 10.9294 0 8.72141 0 0 11.2987 9.93278 0 10.4153 11.5845 11.1412 10.5744 A0A8P0S9Q1 A0A8P0S9Q1_CANLF Ankyrin repeat and BTB domain containing 1 ABTB1 Canis lupus familiaris (Dog) (Canis familiaris) SFLCHKAFF;SIPLVDDIRF;VEGCSFLC;VLYYIYSDHTEL 4 7.3 1.0001 -2.8339 0 0 0 0 8.83453 0 0 0 0 6.78228 0 0 0 9.70132 0 A0A8P0S9Q3 A0A8P0S9Q3_CANLF "TAL bHLH transcription factor 1, erythroid differentiation factor" TAL1 Canis lupus familiaris (Dog) (Canis familiaris) "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]" APKHTARS;GAGGGGGG;GGGGGGGA;GGGGGGGG;NRVKRRPSPYEMEITDGPHTK 5 12.8 1.0033 -1.0566 7.56712 0 0 0 0 0 0 0 0 0 0 0 0 6.89627 0 A0A8P0S9R4 A0A8P0S9R4_CANLF Solute carrier family 8 member A2 SLC8A2 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] plasma membrane [GO:0005886] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] GPGTIVGSAAFNMFVVIAVCIY;GVHYEDACGE;KPGETQKELRIGI;SIELDGTFVGAEVP;SPPPPPPLCLRLLLLPP;TVTILDDDHAGI 6 8.1 0.98632 -0.41075 0 9.58613 0 0 8.05333 9.17809 0 0 8.63844 0 7.55758 7.86956 0 8.50072 9.35957 A0A8P0S9T7 A0A8P0S9T7_CANLF 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; proteasome complex [GO:0000502] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ALWDLAAD;GLAPPALWDLAAD;IKESDTGLAPP;INVKQFAKFV 4 7 1.0031 -1.0274 0 0 0 0 0 0 0 0 10.597 0 4.86557 0 0 0 0 A0A8P0S9V6 A0A8P0S9V6_CANLF Transmembrane protein 213 TMEM213 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VDEYGWIAAAVGWSLWFL 1 16.8 0.98092 0.048313 0 0 0 7.4776 0 0 0 0 0 0 0 0 0 0 0 A0A8P0S9X0 A0A8P0S9X0_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] APPPPVLLLR;SVDFPEFLGM 2 5.5 1.0032 -0.78322 0 0 0 0 0 0 0 0 0 0 9.68226 0 0 0 4.67717 A0A8P0S9X6 A0A8P0S9X6_CANLF Ras-related protein Rab-10 RAB10 Canis lupus familiaris (Dog) (Canis familiaris) localization within membrane [GO:0051668] Golgi apparatus [GO:0005794]; phagocytic vesicle membrane [GO:0030670]; plasma membrane bounded cell projection [GO:0120025]; recycling endosome membrane [GO:0055038] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GKGEQIAREHGI;VELQGKKIKLQIW 2 12.6 0.991 -0.19523 4.17688 0 0 0 0 0 0 13.9792 0 0 0 0 0 0 0 A0A8P0S9Z7 A0A8P0S9Z7_CANLF F-box and leucine rich repeat protein 13 FBXL13 Canis lupus familiaris (Dog) (Canis familiaris) ASPRSRPGSGPP;ITDGSLMSLSPLKQ;YLTSLSIAGCPKIT 3 4 0.99221 -0.14441 0 0 0 6.62963 0 0 10.7548 0 0 0 0 0 0 3.83915 8.29843 A0A8P0SA06 A0A8P0SA06_CANLF Brain expressed X-linked 4 BEX4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ENAQQENEEQ 1 8.5 0.98989 -0.2658 0 0 0 0 0 0 0 0 0 0 0 0 0 9.89377 0 A0A8P0SA11 A0A8P0SA11_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) DMPK Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HYKEHLSL;PGSLSLTY;SKFGERIPAE;VLTRQSLSQE 4 5.6 1.0034 -1.1044 0 9.40024 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SA22 A0A8P0SA22_CANLF Dihydropyrimidinase like 5 DPYSL5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]" GTTMVIGH;KEDFTKIPHGVSGVQ;LADTPTRPVTRHGGMRDLHESS 3 8.2 1.0022 -1.4493 0 9.54738 0 0 0 9.85832 0 0 0 0 0 0 0 0 0 A0A8P0SA27 A0A8P0SA27_CANLF Embryonic ectoderm development EED Canis lupus familiaris (Dog) (Canis familiaris) CHSQGEIRLLQSYVDADAD;DENFYTCAWTYDS;GGGGGGSG;IIRIINPITM;SNPDLSGDE;VGSNRVTLYECH 6 13.6 1.0025 -0.98623 0 10.0121 0 14.8544 10.5658 0 0 0 0 0 3.39383 0 8.41054 0 0 A0A8P0SA33 A0A8P0SA33_CANLF Lysophosphatidylserine lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (Monoacylglycerol lipase ABHD12) (Oxidized phosphatidylserine lipase ABHD12) ABHD12 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] RDFKVQFIPFHSDLGYR 1 7.1 0.97833 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4457 0 A0A8P0SA49 A0A8P0SA49_CANLF Signal transducing adaptor molecule STAM Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091]; ubiquitin binding [GO:0043130] DPGTVANKKE;TVQFSDDVQVETI 2 4.7 1.0019 -0.90715 0 0 0 0 7.93981 0 0 0 0 0 0 0 0 0 0 A0A8P0SA52 A0A8P0SA52_CANLF Cubilin CUBN Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ATGACGGF;DASSACMEDYTENSGT;DICSVNNGGCHPEA;DIYSPPLGP;GACPTGWQGNGYSC;GVFNVSTGVIKS;HEFLQIHDGDSSAAL;IAVFQSQETPAQG;IFRKFHLE;LSNPCFNGGTCVDGVNAFSCEC;NHGFMAKF;NPCQNGGTCLNLHDSFFCIC;PGERICRWT;PLRGRYCGTSMPHPITSFSS;QQGGGFLA;SEHVTIFNGIRNNSPQLEKLCGSVN;SLDIEAQRTCDY;TCLPGYTGNGYGPNGCAQ;TTSFSSSRNSL;VEHVGFHAEY;VGFKIKYAIA;VGHQEKGF;VGYVHDVNCFWVIRTE;VTVTFYFISIDDPG 24 8.8 0.99692 -7.4962 13.5628 12.9316 9.75109 10.1371 10.26 0 8.774 12.4987 13.5772 10.1702 8.33311 10.5428 9.8781 13.9926 11.2897 A0A8P0SA84 A0A8P0SA84_CANLF Coiled-coil domain containing 122 CCDC122 Canis lupus familiaris (Dog) (Canis familiaris) HKRGEPEREKDSRMSG 1 5.5 0.95836 0.051277 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.07296 A0A8P0SAB2 A0A8P0SAB2_CANLF Patched 2 PTCH2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hedgehog receptor activity [GO:0008158] LTLLGLLHGLVLLPVLL;LVTQGGFDYAHSQR;PATQAPRTWLHYYRN;TVLTLLGLLHGL 4 4 0.98686 -0.45842 0 0 0 0 0 1.71787 0 8.80629 0 0 0 0 4.80936 0 0 A0A8P0SAB4 A0A8P0SAB4_CANLF "Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (Mitochondrial sulfonylurea-receptor)" ABCB8 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion transport [GO:0006813] membrane [GO:0016020]; mitochondrion [GO:0005739] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DSESERVVQEALDR;ILDEATSALDSESERVVQEAL;VGERGATLSGGQ;VGIRGGPV;VNVQIPLLLGQLVEIVAKYTRDH;VRAFAMENREE 6 11.3 1.0047 -1.1044 0 0 0 0 0 0 0 0 2.3883 0 0 0 0 0 0 A0A8P0SAD1 A0A8P0SAD1_CANLF CD177 molecule CD177 Canis lupus familiaris (Dog) (Canis familiaris) TPIKWTPNNYELCNI 1 3.6 0.95185 0.053902 9.65308 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SAD5 A0A8P0SAD5_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" B4GALT2 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] APSSGLPEAPSARPGPT;GVSGLSKAQFLRINGFPNEYW;VILYFDVYAQ 3 14.4 1.0015 -0.69834 0 0 0 0 10.2497 0 0 5.92588 0 0 0 0 0 0 10.0745 A0A8P0SAE2 A0A8P0SAE2_CANLF IQ motif containing with AAA domain 1 like IQCA1L Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] DLSEYHCLDHV;KEEKEMDPKRIKK 2 2.9 0.92413 0.095052 0 6.66676 0 0 0 0 0 0 0 0 0 0 0 0 3.97838 A0A8P0SAE4 A0A8P0SAE4_CANLF Armadillo like helical domain containing 1 ARMH1 Canis lupus familiaris (Dog) (Canis familiaris) GVSHRNSSFPRG;SEETQEEVQILM 2 5.4 0.85974 0.16997 11.915 8.50831 0 0 0 0 0 0 13.8463 0 0 0 0 0 0 A0A8P0SAF3 A0A8P0SAF3_CANLF Integrator complex subunit 4 INTS4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] nucleus [GO:0005634] ADFRNPGPGRHRLITQVY;LLSTHPFF;SEEDAALCADALRILEGEKRSVVKF;SPKACTDAEGRLFI 4 5.9 0.98727 -0.35484 0 0 0 0 0 0 7.01737 9.19096 0 0 0 0 0 0 9.19503 A0A8P0SAG3 A0A8P0SAG3_CANLF Protocadherin 20 PCDH20 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEDGGSPP;DGGSPPLLGS;ELTIEENNA;KLTILANG;LLELTIEENNAP;PVTEVYAVDKDTGMNAV;STQLDREEKEK;TIIKVIFRPPEIVPRY 8 8.2 0.99812 -3.3251 11.1111 8.87427 4.04334 8.18448 4.51822 0 0 0 0 10.3735 7.94778 0 8.89794 9.35304 8.41397 A0A8P0SAH7 A0A8P0SAH7_CANLF Transmembrane protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FVIKKKKKK;FVIKKKKKKNV 2 5.6 1.0027 -0.76872 2.75606 0 0 0 0 0 0 0 0 0 0 0 4.99539 0 0 A0A8P0SAH8 A0A8P0SAH8_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT11 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] WLQPLLAA 1 1.3 1.0043 -1.1044 0 0 0 0 0 0 0 0 8.52235 0 0 0 0 0 0 A0A8P0SAM4 A0A8P0SAM4_CANLF Xylulose kinase (EC 2.7.1.17) XYLB Canis lupus familiaris (Dog) (Canis familiaris) D-xylose metabolic process [GO:0042732]; xylulose metabolic process [GO:0005997] ATP binding [GO:0005524]; D-xylulokinase activity [GO:0004856] AEGLGYRVMPKT;PVPSCSVVGAISSY 2 4.9 0.98981 -0.20083 0 0 0 0 0 0 0 0 0 0 0 0 10.2159 0 0 A0A8P0SAM7 A0A8P0SAM7_CANLF Motor neuron and pancreas homeobox 1 MNX1 Canis lupus familiaris (Dog) (Canis familiaris) spinal cord motor neuron cell fate specification [GO:0021520] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" DSDPEEDEEDEDEDH;ESSEPPAAPADRL;GGGGGGGA;GGGGGGGG;QKGGGGAS;TSLAAAASGPAGGG 6 13.7 1.0028 -1.489 0 0 0 0 0 0 0 9.62447 0 6.49593 0 0 0 9.60164 0 A0A8P0SAN2 A0A8P0SAN2_CANLF Tetratricopeptide repeat domain 21A TTC21A Canis lupus familiaris (Dog) (Canis familiaris) FIERTFMATSSY;GHYDKAREYIDCNLKLSNNSREGL;GVTWCQILEGHLEE;IDCNLKLSNN;KKEDVMETLNKAMDLQ;LHLKKILVVSRL;LSGELENAQSTLQRCLE;NWPGSTVIMPTPLLASSSLSTT;VMQDAINEFSGTPEEIRITIA 9 12.2 0.98803 -0.26487 0 0 9.62141 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SAN5 A0A8P0SAN5_CANLF Sodium channel protein SCN5A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] AEMTFKIIAL;APRPQLDLQASK;FRVIRLARIGRILRLIRGA;IRLARIGRILRLIRGAK;LVMFIYSIFGMA;MVTMMVETDDQSP;QAPCVDGFEEPGE;SEDDFDMFYEIWE;SVEADGLVWESLDHYLS;TLFRVIRLARIGRILRLIR;TTPSEEPG;VGAGYLAL;VIRLARIGRILRLIRGAKGI;VLRSFRLLRVFKLAKSWPTLN;VLSDIIQKYFF;WNWLDFSVIVMAYTTEFVDLGNVSA 16 9.3 1.003 -1.9521 0 8.92354 5.95926 3.95448 0 12.5708 8.40552 7.47614 0 0 11.7825 6.91205 0 10.3194 11.9983 A0A8P0SAN9 A0A8P0SAN9_CANLF Scm like with four mbt domains 2 SFMBT2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] histone binding [GO:0042393]; transcription corepressor activity [GO:0003714] ATGSGEESEEEDADAM;EEDADAMDEDTG;EEDADAMDEDTGSEETSSELRDDQ;ERLVLESN;GEDRRADFWCDVVIADLHPV;GKRKKIIKP;QENKYRMDPP;QSVGPGKCVLVLKEVLS;TIDDLRAEPSKLS;TVQECMELKLGPAI;WTEFLIRDLTGSR 11 15.3 1.0032 -1.9363 0 0 0 0 8.73352 8.62081 10.2849 13.5774 9.91016 0 9.01246 0 9.65272 0 10.7549 A0A8P0SAR6 A0A8P0SAR6_CANLF Cytochrome P450 family 2 subfamily S member 1 CYP2S1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" DPSLLLAQATSNIICS;LLLALLLLLLLLAL;LLLALLLLLLLLALARP;LLLLLLLL;LLLLLLLLALARPRTRGHL;TLLLALLLLLLLLALA;WGTFNRQPSP 7 9.2 0.99474 -0.1574 0 0 0 0 0 5.9427 0 0 0 0 2.49288 0 0 0 0 A0A8P0SAR9 A0A8P0SAR9_CANLF Dynein 2 intermediate chain 1 DYNC2I1 Canis lupus familiaris (Dog) (Canis familiaris) intraciliary transport [GO:0042073] cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868] dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503] HLFLYLLSSVLTVWEGGRG;TVWEGGRGPKCISIS 2 12.3 0.99572 -0.01564 0 0 0 0 0 0 0 0 0 0 13.4596 13.3582 0 7.90485 0 A0A8P0SAS0 A0A8P0SAS0_CANLF Trafficking kinesin protein 1 TRAK1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] APNDDTLANSVPPLEACNHAV;DTLANSVPP;ERSKKPGTPGTPGSHDLE;ISAAVYDPQ;SPGIPEEH;VAKVVNSGRAHVPT;VTSAIGGL 7 8 1.0031 -1.5289 0 0 13.3336 0 0 8.51321 0 0 0 0 0 0 0 0 16.8499 A0A8P0SAS2 A0A8P0SAS2_CANLF Cell death inducing DFFA like effector c CIDEC Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] SLSYDLHCYGAK 1 5 0.98529 -0.25922 0 0 0 0 0 0 11.1161 0 0 0 0 0 0 0 0 A0A8P0SAS3 A0A8P0SAS3_CANLF guanylate cyclase (EC 4.6.1.2) Canis lupus familiaris (Dog) (Canis familiaris) cGMP biosynthetic process [GO:0006182] membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] SYLALGNS 1 1.1 1.0045 -1.1044 0 0 0 0 0 0 0 10.5117 0 0 0 0 0 0 0 A0A8P0SAS4 A0A8P0SAS4_CANLF Trafficking kinesin protein 1 TRAK1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] ERSKKPGTPGTPGSHDLE;ISAAVYDPQ;TNSCDVCNSTDLPEV;VAKVVNSGRAHVPT;VTSAIGGL 5 6.7 0.99187 -0.18314 0 0 0 0 0 0 0 13.2162 0 0 13.4658 0 0 13.3157 0 A0A8P0SAS5 A0A8P0SAS5_CANLF Glucokinase regulator GCKR Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate derivative metabolic process [GO:1901135] carbohydrate derivative binding [GO:0097367] KKRVIVIGI;LLQVIHFPQPLSDDI;SNPLTQDLDKADAEQIV;STDPLEALEPAL 4 8.5 1.0025 -0.8447 0 9.19052 11.5104 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SAT3 A0A8P0SAT3_CANLF FA complementation group D2 FANCD2 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] GVGVPELINSP;GVPELINSPKDASSSMFPTLTR;VTPPTTAAISA 3 2.4 0.99704 -0.087821 9.36757 0 0 6.37016 0 0 6.52217 0 6.23299 0 0 0 0 0 0 A0A8P0SAT4 A0A8P0SAT4_CANLF Hydroxypyruvate isomerase (putative) HYI Canis lupus familiaris (Dog) (Canis familiaris) GLCPAAGP;QLQMDLFHWQIMDGNL 2 4.2 1.0038 -1.0552 0 0 0 0 0 0 0 0 9.95934 0 0 0 0 0 0 A0A8P0SAV3 A0A8P0SAV3_CANLF Biliverdin reductase B BLVRB Canis lupus familiaris (Dog) (Canis familiaris) GQDAVIVLL;SGSVSVSHRGMAGGGGGV 2 10.3 0.98775 -0.34841 0 0 0 0 0 0 0 0 0 0 0 0 7.97045 0 0 A0A8P0SAW4 A0A8P0SAW4_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) ALK Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] AAGGKGGK;ACDFHQDCAQGEDEG;CSHCEGDECHMDPES;DGVPVPLI;DLLHVAQDI;GGGGGGGA;GGGGGGGG;HYLNCSHCEGDECHMD;MDPPKNCPGP;PKSRNLFERNPN;PLSYSRLQ;QPSSLAMLDLL;RGGFGGGG;SFLRETRPRPNQP;YCNFENGFCGW 15 8.4 0.99747 -3.768 4.60851 0 6.23596 9.5566 7.50263 6.77716 9.45734 0 5.75531 8.38379 0 5.54034 8.82906 0 9.12784 A0A8P0SAW6 A0A8P0SAW6_CANLF Proline rich transmembrane protein 3 PRRT3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PDSQEPREQEALAL;VGAGSLDL 2 2.2 0.98866 -0.20305 16.7036 16.5633 0 0 0 0 16.7136 16.5046 0 0 0 0 0 0 0 A0A8P0SAX5 A0A8P0SAX5_CANLF Neuroepithelial cell transforming 1 NET1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] EDLLARIGEATKPG;FSRKLDLWSFL;LPIKRTIRVLDVSHPSFR;TPAKRRSSVLWSEMLDV;VAVGGGSG;VTRNERHSYQVYRQPIP 6 12.9 1.0032 -1.3357 0 0 0 0 9.20526 0 9.23271 8.46197 9.69959 0 0 8.59451 0 0 0 A0A8P0SAX8 A0A8P0SAX8_CANLF Serine/threonine-protein kinase receptor (EC 2.7.11.30) TGFBR2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane raft [GO:0045121]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] "ATP binding [GO:0005524]; metal ion binding [GO:0046872]; transforming growth factor beta receptor activity, type II [GO:0005026]" CDFGLSLRLDPTLSVDDL;ETLTECWDHDP;HVISWEDLRKLG;KDYEPPFGSK;KLSPSWETSKPRKL;MCSCSSDECND;VGTARYMAPEVL 7 16.6 1.0022 -1.0008 9.78849 0 0 0 0 0 0 0 12.5967 0 0 0 0 11.0993 0 A0A8P0SAZ5 A0A8P0SAZ5_CANLF Fibrillarin FBL Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; rRNA processing [GO:0006364] ribonucleoprotein complex [GO:1990904] methyltransferase activity [GO:0008168]; RNA binding [GO:0003723] HIKPGAKV 1 2.6 1.0033 -1.1044 0 0 0 0 0 0 6.51368 0 0 0 0 0 0 0 0 A0A8P0SB02 A0A8P0SB02_CANLF Ovo like zinc finger 2 OVOL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DEERADTYIPVG;EDCRSDGGSSSGGGS;LPDEERADTYIPVGAR;TGIRPYKCD;VQQQYAYKQR 5 15.9 1.002 -1.2157 0 0 0 9.31504 0 7.57418 12.997 0 0 7.96965 0 0 7.67779 0 0 A0A8P0SB03 A0A8P0SB03_CANLF Galectin-3-binding protein (Lectin galactoside-binding soluble 3-binding protein) CANT1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576]; membrane [GO:0016020] QSFQTPQHPSF;TLDLSGELPAAL;TVTMEVDAECLP;YALATQDPVL 4 8.2 1.0045 -0.81681 8.59051 0 0 0 0 0 0 0 0 0 0 0 8.92707 8.74833 0 A0A8P0SB08 A0A8P0SB08_CANLF Sterile alpha motif domain containing 4B SAMD4B Canis lupus familiaris (Dog) (Canis familiaris) regulation of mRNA stability [GO:0043488] cytoplasm [GO:0005737] RNA binding [GO:0003723]; translation repressor activity [GO:0030371] HKIALSIQKLRERQSVLKSL;LLVSRPDEENITSY;TDKGTESKDP 3 6.3 0.99344 -0.070255 0 0 0 0 0 0 0 11.4205 0 0 0 0 5.95203 0 9.169 A0A8P0SB20 A0A8P0SB20_CANLF ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) PFKP Canis lupus familiaris (Dog) (Canis familiaris) fructose 6-phosphate metabolic process [GO:0006002] cytoplasm [GO:0005737] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] ADAAYIFEEPFDIRDL;HGEIDKEQVQKHAYLNV;NSVPGTELSLGC 3 5 1.0016 -0.69345 0 0 0 0 0 0 0 0 12.046 0 0 0 0 9.39842 0 A0A8P0SB33 A0A8P0SB33_CANLF Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) GAA Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] lysosomal membrane [GO:0005765] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] CDVPPNSRFDCAPD;CNGVPVAFTYNPDT;FPDFTSPTALDW;IVDPAISSSSPPG;TLWNRDIAPSPNVNLY 5 7.7 1.0004 -0.61251 7.97459 0 0 0 0 0 0 8.61069 0 0 0 8.56201 0 0 10.8908 A0A8P0SB38 A0A8P0SB38_CANLF Importin 5 IPO5 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] DFSDMEDDDPQIS;EKFVPYYDLFMP;FPGIFGNQQQHY;HRPWPDRQW;LDTQDMENMSDDDGW;TEALPLLVRVIQ;VPYYDLFMPSLKHIVE 7 7.7 1.0037 -0.82289 0 0 0 0 0 4.86151 7.43379 0 9.07844 9.78129 2.71684 2.92321 9.2677 0 7.16541 A0A8P0SB49 A0A8P0SB49_CANLF Multifunctional fusion protein [Includes: Synaptosomal-associated protein 25 (SNAP-25); Synaptosomal-associated protein] SNAP25 Canis lupus familiaris (Dog) (Canis familiaris) neuron projection [GO:0043005]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; synapse [GO:0045202] syntaxin-1 binding [GO:0017075]; voltage-gated potassium channel activity [GO:0005249] ELMRPTNVQQ;LVMLDEQGEQLDR 2 8 0.99547 -0.15386 0 0 0 0 8.28313 7.96561 11.024 0 0 0 0 0 0 8.114 0 A0A8P0SB54 A0A8P0SB54_CANLF TNF alpha induced protein 6 TNFAIP6 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] hyaluronic acid binding [GO:0005540] FPNEYDDNQICYWH;GVRLNRSERWD;ISLFVLLWE 3 12.3 0.98957 -0.52203 0 0 0 0 0 0 9.4783 0 9.61739 0 0 0 0 0 0 A0A8P0SB78 A0A8P0SB78_CANLF CXXC-type zinc finger protein 5 CXXC5 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] STEMLKRVV;TEMLKRVV 2 2.8 0.98539 -0.23543 0 8.51511 0 11.9712 0 12.6113 14.2814 0 13.4142 0 0 0 9.05786 13.1092 0 A0A8P0SB81 A0A8P0SB81_CANLF FA core complex associated protein 100 FAAP100 Canis lupus familiaris (Dog) (Canis familiaris) interstrand cross-link repair [GO:0036297] Fanconi anaemia nuclear complex [GO:0043240] CPRPGNDARPGGQV;GPARWKVQ;GVAPDGTEVHLT;QTLRDRLCTEDEASSCTT;VQTLRDRLCTEDE;VTLPLGPGEDGA 6 7.4 1.0021 -1.426 0 0 0 0 0 0 7.11842 0 0 0 0 0 0 0 0 A0A8P0SB87 A0A8P0SB87_CANLF BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) BAIAP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane organization [GO:0007009]; regulation of actin cytoskeleton organization [GO:0032956] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; membrane [GO:0016020]; ruffle [GO:0001726] cytoskeletal anchor activity [GO:0008093] DVLFQMAEVHRQIQNQLEEML;ESPLPGPS;KYSDKELQYIDAISNKQGELENYV;LVPEARDGWHYG;TEQRSKGDALDK 5 9.2 1.0043 -1.1044 0 0 0 0 7.66099 0 0 0 0 0 0 0 0 0 0 A0A8P0SB90 A0A8P0SB90_CANLF UBA domain containing 2 UBAC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DLILVEAM;LLLPHCQRFFVYD;PLEVSEEQNRGS;VQVLVPWYYSYKAPLSK 4 15 1.0022 -0.66888 0 0 0 0 0 8.27598 0 5.47434 0 0 0 0 6.48798 0 0 A0A8P0SB95 A0A8P0SB95_CANLF Transcription factor E2F7 E2F7 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] EPSLLQYLYVQ;LVDQRQQTEPWTP;PVSSAAGALPDP;QTEPWTPTAN 4 4.4 0.98773 -0.22785 0 0 0 0 0 0 11.339 0 0 0 0 0 0 0 0 A0A8P0SBA8 A0A8P0SBA8_CANLF Latent transforming growth factor beta binding protein 1 LTBP1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] DINECLEDNSVCQGGDC;GFNKCQKCPKKPSYHGYN;HGPGVAEPEV;INTEGSYDCTCPDGFQLND;ISEEKGPCYRLVSSGRQCMH;PGAPSERTRRTSP;PLRYGQGQVTAPFQLSN;QPGYECYCKQ;SISADGHTCE;SLDQEKTKLEPGQPQL;TTYTECCCLYGEA 11 9.5 0.97804 0.046227 0 0 0 10.5535 0 10.6261 0 0 0 0 0 0 0 0 0 A0A8P0SBB2 A0A8P0SBB2_CANLF Solute carrier family 38 member 10 SLC38A10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FEQQQKDGTFAA;QWLQRIRYVRWDGVFRC;RCIPIFGMSFACQSQVLP;VPHDKVVVD 4 5 0.98742 -0.47944 0 0 0 0 0 0 0 0 0 8.6675 0 8.06237 0 0 8.59801 A0A8P0SBB4 A0A8P0SBB4_CANLF Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) MAP4K1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349] FIGTPYWMAPE;QEATLEMLF;SPSDEGPTGGTGDEGQLSPG 3 5 0.98755 -0.22955 0 0 0 0 0 0 8.25399 0 0 0 0 0 0 0 0 A0A8P0SBB7 A0A8P0SBB7_CANLF ADAM metallopeptidase domain 9 ADAM9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AECAYGDCCKDCW;CDCGTPKECESDPCCEGTTCK;CYNGMCQYYD;IMNSGASGSRNFSSCSAEDFEKL;KDMEKETTNYEEE;VFFFLIVPLIV;VPEYCNGSSQFCQP 7 13.6 1.0024 -0.99103 0 0 9.25708 0 8.30204 0 0 13.1312 0 0 0 9.27778 0 12.6719 0 A0A8P0SBB9 A0A8P0SBB9_CANLF DND microRNA-mediated repression inhibitor 1 DND1 Canis lupus familiaris (Dog) (Canis familiaris) germ cell development [GO:0007281] RNA binding [GO:0003723] NGQRKYGGPPPGWV 1 4 0.98402 -0.24778 0 0 11.7054 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SBC6 A0A8P0SBC6_CANLF Myeloid-associated differentiation marker-like protein 2 MYADML2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AVLLYLSAAVIWPVF;TQWCVAVYSLC 2 8.5 0.9875 -0.49782 0 0 0 0 0 0 0 12.113 0 0 0 0 0 0 0 A0A8P0SBE6 A0A8P0SBE6_CANLF Striatin STRN Canis lupus familiaris (Dog) (Canis familiaris) protein-containing complex [GO:0032991] calmodulin binding [GO:0005516]; protein-containing complex binding [GO:0044877] AAADFSDEDEDDD;DQCLVPEAWNVDQGV;GPVLCVVMSSNGEQCYSG;HKGPVLCVVMSSNGEQCY 4 6.2 0.98724 -0.32675 0 9.42876 0 10.4618 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SBF0 A0A8P0SBF0_CANLF ALX homeobox protein 1 (Cartilage homeoprotein 1) ALX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AFETKPEFERRSSSIAV 1 5.2 0.97844 0.046227 0 0 0 0 0 0 9.54695 0 0 0 0 0 0 0 0 A0A8P0SBF1 A0A8P0SBF1_CANLF RAS guanyl releasing protein 4 RASGRP4 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085] DSHAHLSPDSTKALLE;SLEPETGCHLCHAWTQTEP;TKQGYRCRD;VEQLVESVFKNYD;VEQLVESVFKNYDPEGRG 5 9.2 1.0026 -0.72289 0 0 0 8.12882 9.99859 0 0 0 0 13.4384 0 0 11.0107 0 0 A0A8P0SBF2 A0A8P0SBF2_CANLF WD repeat domain 87 WDR87 Canis lupus familiaris (Dog) (Canis familiaris) AGKEPGPLEGE;AKPQSKVSSKILKALQDLTK;DTTNSNPLIRELAWE;EAEKKLTQLEESL;EEEKRSWEKEIIRK;EGAIREDIMTE;EGEKEEGEEEEEVFEEEEEESI;EITSMEALNATEL;EKEKKEKKKKKKKKKVQ;EKKKKKKKKKV;EPYRSARAEQVS;EQESLSEEEEEEEEEEEEEEEEEEE;GQLGEVQRFTSTT;IQEEEEEELTEDEE;KEKEKKEKKKKKKKK;KKKKKKKK;KKKKKKKV;KRKKLMENKLKLAQE;KSEDLVEKRTFSMS;KYLKVIPPI;LQDLTKEEMKLTQE;LSEEEEEEEEEEEEEEEEEEEN;LTLKLLRKI;NYVHLSEAVLE;PGLKTPYLFQILRKTIE;QDLTKEEMK;SEEMESLVGEVE;SLSEEEEEEEEEEEEEE;SLSEEEEEEEEEEEEEEEE;VGEVEQESLSEEEEEEEEEEEEEE;VGEVEQESLSEEEEEEEEEEEEEEE;VILKKGKKKKAIFLK;VILKKGKKKKAIFLKSD;VILKKGKKKKAIFLKSDGL;VIPLLGQKKGRKLKTMDIPQKEVP;YYVLRMLQQRYAKDHAAWME 36 12.3 0.99723 -3.7951 7.31796 7.39197 0 7.02348 6.70584 11.646 9.6563 9.31422 10.2292 10.3067 5.37083 4.56919 0 8.7489 9.36977 A0A8P0SBF3 A0A8P0SBF3_CANLF Cation channel sperm associated auxiliary subunit gamma CATSPERG Canis lupus familiaris (Dog) (Canis familiaris) CatSper complex [GO:0036128]; sperm principal piece [GO:0097228] DYQLTFLLHIH;EMPCFLFRDIFYPFFL;LLMLVEIEAPTTRN;PHTIFAPEFFFKVLV;QLVYYFTGTYITLHESN;QSSLYTSNETMVT;VPSRPLWHTVDQAPVL;WKIEQLQIQMEAAPFRSKEECIAE;YEDSKLYQLVYLMNNQKG 9 12.5 0.9877 -0.36702 0 0 0 4.00693 0 0 0 13.1659 9.71843 0 0 0 7.21645 7.17762 0 A0A8P0SBF6 A0A8P0SBF6_CANLF tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 TRMT6 Canis lupus familiaris (Dog) (Canis familiaris) tRNA methylation [GO:0030488] nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515] GGSLQPKK;RKKVTFEK 2 3.2 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 9.38057 0 0 0 A0A8P0SBF8 A0A8P0SBF8_CANLF FERM domain containing kindlin 1 FERMT1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] EDEQLLLRFKYYTFFDLNPKYD;GTPASSTM;IVRVDDPNEEEQKDVTLRV;LLKPSGDYFKKKKKKD;PEALADMYQ;VEQIKISQDWSDFALWWEQKHCWL 6 14.1 1.0024 -1.8565 0 0 5.48887 0 0 0 8.33891 0 11.5254 0 0 0 11.541 0 0 A0A8P0SBG6 A0A8P0SBG6_CANLF HEAT repeat containing 5B HEATR5B Canis lupus familiaris (Dog) (Canis familiaris) ACQVCSTWIGSGVVSDLND;GVELLSVLHRLL;GVSSRSDIHCRHQ;LRQLAQREAA;MHIGPLYP;MRSFVAHCPELLTEDVIRKLMT;NGLGGAAAS;QDHSDSLVQAAAISCLQ;SQPEDSMP 9 5.7 1.0031 -2.1512 0 8.30675 8.46699 6.82171 8.85515 0 0 8.05306 0 11.8441 9.63319 0 0 9.66196 12.148 A0A8P0SBH0 A0A8P0SBH0_CANLF WD repeat domain 87 Canis lupus familiaris (Dog) (Canis familiaris) CFYSISVNYFVSLNW;DISMAGEPE;EEEEPGVKEEELTWD;EEELGEEEEE;EESLSEEEEEEEEEEES;ESRLMKVIRSEE;GKKKKAIARKGIGITKRKKK;IGKKKKAIARKGIGITKRKK;IGKKKKAIARKGIGITKRKKK;KKQLKKLLRRIEKNKP;LDKLVLEKRKFKKEARKL;LQKNKVILQPINKILCACALTH;PSFFLSFERIFVPKFVYLGQGL;QAKRRQLIKKELRV;QLKKLLRRIEKNKPEKTQLK;RSQTPEALNWHLLAESQ;SEEEEELGEEEE;VEEEEHAG;VHLKVIPP;VLPSATRR;WMETMEMEGQ 21 7.8 0.97783 0.046227 4.60122 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SBK6 A0A8P0SBK6_CANLF Pantothenate kinase 2 PANK2 Canis lupus familiaris (Dog) (Canis familiaris) coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594] APSVSRQRVESLRKKRQLF;LTGCTTFEEALEMA;NIAASQGRH;VGASASASA 4 6.1 0.98953 -0.26528 0 12.515 5.90648 6.62155 0 7.60125 9.68624 13.5976 0 6.1994 0 0 12.637 0 0 A0A8P0SBM0 A0A8P0SBM0_CANLF Transmembrane and coiled-coil domain family 3 TMCC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTSGSADS;GVNQILRKRRPVW;IRVGVNQILRKRRPVWE;VGVNQILRKRRPVW 4 3.7 0.98937 -0.21763 0 0 0 0 0 0 9.57421 8.34567 0 0 0 0 0 0 0 A0A8P0SBM4 A0A8P0SBM4_CANLF DAP3 binding cell death enhancer 1 DELE1 Canis lupus familiaris (Dog) (Canis familiaris) KSTNPDGFQ 1 1.9 1.0031 -0.80421 0 0 0 0 0 0 7.35782 0 0 0 0 0 0 0 0 A0A8P0SBM5 A0A8P0SBM5_CANLF Olfactomedin-like domain-containing protein LOC119864860 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] LVLMKNYKEWTMGYG 1 3.2 0.9839 -0.24311 0 0 0 0 0 0 0 0 0 0 0 0 10.0941 0 0 A0A8P0SBP3 A0A8P0SBP3_CANLF Tripartite motif containing 22 TRIM22 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CLELLTMPLSL;EDEVNVLDNLIVARDQFAQQKQCL;QEKLQAALKKLRKEHTKVE 3 11.1 0.62009 0.34905 0 11.9664 0 0 8.962 0 0 0 8.60326 12.0716 0 0 0 0 0 A0A8P0SBP6 A0A8P0SBP6_CANLF Olfactory receptor OR52N4G Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FPFCSMYIVAMVGN;VLMLMALDR 2 7.1 0.9375 0.063384 0 0 0 0 0 0 0 0 0 0 12.3763 0 0 0 0 A0A8P0SBS5 A0A8P0SBS5_CANLF "Pro-neuregulin-1, membrane-bound isoform" NRG1 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] extracellular region [GO:0005576]; plasma membrane [GO:0005886] growth factor activity [GO:0008083] PEGGQSPV;TAHHSTTVTQTP 2 4.4 1.004 -1.1044 0 0 0 0 0 0 0 0 7.09497 0 0 0 0 0 0 A0A8P0SBT2 A0A8P0SBT2_CANLF IF rod domain-containing protein BFSP2 Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] RHRASFGGTWSSSSLDSPPASRT;VGEAVLENARLM 2 8.4 0.9834 -0.25387 0 0 0 0 0 0 0 8.40173 0 0 0 0 0 0 0 A0A8P0SBT7 A0A8P0SBT7_CANLF SH3 domain containing ring finger 2 SH3RF2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; transferase activity [GO:0016740] KDDIITVISRVD;VGIFPNNYVIPIFRKTS;YPDGWLRG 3 5 1.0018 -1.3114 0 0 0 9.79054 8.21965 0 0 0 9.57204 0 0 0 0 0 0 A0A8P0SBU0 A0A8P0SBU0_CANLF 3'-5' exonuclease (Werner Syndrome-like exonuclease) WRN Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] EYSAAARASAHARRAASWA;KYINKIKLIRKL;LEKEMIKSLENLNTGMA 3 5.3 0.94726 0.05044 0 0 0 0 0 0 0 5.6065 0 0 0 0 0 0 0 A0A8P0SBV5 A0A8P0SBV5_CANLF UPF3A regulator of nonsense mediated mRNA decay UPF3A Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleic acid binding [GO:0003676] APFQKIAKKKLKKKDAKTG;EVRIKLLKK;PFQKIAKKKLKKK 3 7.9 1.0015 -0.69524 0 0 0 0 0 4.92048 0 0 0 2.98432 0 2.99509 0 0 0 A0A8P0SBV8 A0A8P0SBV8_CANLF 3'-5' exonuclease (Werner Syndrome-like exonuclease) WRN Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] KYINKIKLIRKL;LEKEMIKSLENLNTGMA;WTKYINKIK 3 4.3 0.99206 -0.27195 0 0 0 0 8.82499 0 0 0 0 0 0 0 0 0 0 A0A8P0SBW7 A0A8P0SBW7_CANLF Coatomer subunit zeta COPZ1 Canis lupus familiaris (Dog) (Canis familiaris) "intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] EAGVAFHPSPSL;EGLFLAVDEI 2 11.3 0.99552 -0.011988 7.50708 6.54722 0 0 0 0 8.1812 0 0 0 0 0 0 0 0 A0A8P0SC42 A0A8P0SC42_CANLF Lin-37 DREAM MuvB core complex component LIN37 Canis lupus familiaris (Dog) (Canis familiaris) transcription repressor complex [GO:0017053] KVKVEKSELEMAKA;TSGGGGCSG 2 6.8 1.0019 -0.74345 0 0 0 0 4.37539 0 0 8.88169 0 0 0 0 0 0 0 A0A8P0SC64 A0A8P0SC64_CANLF RAD21 cohesin complex component like 1 RAD21L1 SNPH Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] cohesin complex [GO:0008278]; nucleus [GO:0005634] DTERWNRRILQ;EQVIVELVSSAAEESSLMN;IQKESVREEVGSENIIETSKTEEPN 3 9.9 0.99458 -0.12866 0 0 0 0 0 0 9.78722 0 0 0 0 0 0 12.8538 0 A0A8P0SCC6 A0A8P0SCC6_CANLF Tripartite motif containing 66 TRIM66 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] GAKKGPPV;HLLCKNCFQGFIQEL;IVPPQDVQQ;KRVYLTRDVNEHFF;LTCSLCQQDLQNVG;PQHPASSQ;QQGAHAQPTLQTPSIQ;VGQINYIVRQ;YDCENARYYQPGMRDTPGLSI 9 8.2 1.003 -1.6659 0 11.5884 0 9.88044 10.3919 0 10.0282 0 7.28854 11.0109 0 5.80923 0 0 2.63143 A0A8P0SCG5 A0A8P0SCG5_CANLF Coiled-coil domain containing 92 CCDC92 Canis lupus familiaris (Dog) (Canis familiaris) SLSAPLHPEFEE 1 4 0.95513 0.05044 0 0 0 0 0 3.83309 0 0 0 0 0 0 0 0 0 A0A8P0SCH0 A0A8P0SCH0_CANLF Small ribosomal subunit protein eS1 LOC607844 RPS3A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; nucleolus [GO:0005730] structural constituent of ribosome [GO:0003735] ESEVDLSAMAVGK;GCVFEVSLADLQ;VRKVKMLKKPKFELGK 3 15.4 0.98666 -0.41968 0 0 0 0 0 0 0 0 19.9565 0 2.95187 0 0 12.2904 0 A0A8P0SCI1 A0A8P0SCI1_CANLF Acyl-coenzyme A oxidase ACOX2 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid beta-oxidation [GO:0006635] peroxisome [GO:0005777] acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949] CYDGNVYERL;LGCYDGNVYERLFHW;TYEGENTVLYLQTA 3 4.3 0.99486 -0.15523 0 0 0 10.9009 0 0 0 0 0 0 9.00079 0 0 0 0 A0A8P0SCI4 A0A8P0SCI4_CANLF CCM2 like scaffold protein CCM2L Canis lupus familiaris (Dog) (Canis familiaris) RPWLCSRSESCRTD 1 2.5 0.93604 0.060864 0 0 0 0 0 0 5.48954 0 0 0 0 0 0 0 0 A0A8P0SCI6 A0A8P0SCI6_CANLF Keratin 3 KRT3 KRT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; keratin filament [GO:0045095]; plasma membrane [GO:0005886] DAQGKLSDLEEALQQARE;DEINKRTNAENEF;GGFGLGGG;GGGGGGGA;NAENEFVTIK;SGGRGSSS;SSSGGGGF;TSSSMSSS;TVSVTSSSMSSSMTSRGGFG;VTLSMDNNRSL 10 16.2 0.99718 -3.9238 12.1277 11.1836 0 0 0 0 9.18903 10.4201 11.3221 8.36912 0 0 0 6.54099 9.12322 A0A8P0SCJ2 A0A8P0SCJ2_CANLF "ERCC excision repair 8, CSA ubiquitin ligase complex subunit" ERCC8 Canis lupus familiaris (Dog) (Canis familiaris) transcription-coupled nucleotide-excision repair [GO:0006283] NFEETVYSHHMSPV 1 3.5 0.93656 0.060949 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.60015 A0A8P0SCK3 A0A8P0SCK3_CANLF Keratin 84 KRT84 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] AELEGALQQAKQDMA;KCARSNLEPLFEN;KKYEEEVGFRA;PSGSGIRSVSTCASSLGGARVI 4 10.8 0.98509 -0.44587 0 9.97312 0 0 0 8.86059 0 0 12.5072 0 0 0 0 0 0 A0A8P0SCK7 A0A8P0SCK7_CANLF Stabilin 2 STAB2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540] DNAATNGV;GPDCQPCRCSDHGQCDD;GVCNSGIDGDGSCECYSA;GVGCSMAD;GVGCSMADVCESKNPCHRNAN;HYHNYMPGVGCSMA;IDGDGSCECYSAYTGS;LGKEIKRCI;NACETSNGGCSS;NEALDNMKDGTL;NGVIHVISKVLIPRRSL;NVCFGNGICLDGVNGTGACECGP;QSHCECKEHY;RGSCAEGMEGNGRCSCQDG;SGDGSCDC;YEGDGLLCYGNAAVE 16 7.7 0.99701 -5.5357 8.35826 0 9.28972 0 9.46371 9.73895 0 8.53784 9.12068 0 13.1465 13.1204 13.0146 6.45832 0 A0A8P0SCL8 A0A8P0SCL8_CANLF Zinc finger CCCH-type containing 6 ZC3H6 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] metal ion binding [GO:0046872]; RNA binding [GO:0003723] DAELEKRKEI;DDTVNWYSSSEEEEG;ENCIYMHNEF;HSPSSDDSSDYSLDSDVEH;IVWAPEDLLPVPLPKPDP;KKHKKEREKKKSKRRKREKH;PDTPLTPP;QGYCTKGENCIYMHNEFPC;SKEEDDTVNWYSSSEEEEGS 9 9.8 1.0028 -2.5574 0 6.206 0 9.47306 0 13.15 5.93704 10.3878 12.4763 0 9.51686 9.11686 13.3597 0 0 A0A8P0SCM0 A0A8P0SCM0_CANLF Potassium channel tetramerization domain containing 6 KCTD6 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] DTRDCQVSFTFGP;PCDYHQEVSL 2 9.3 0.98555 -0.25852 0 0 0 7.11207 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SCP9 A0A8P0SCP9_CANLF Endoplasmin (94 kDa glucose-regulated protein) (Heat shock protein 90 kDa beta member 1) HSP90B1 Canis lupus familiaris (Dog) (Canis familiaris) melanosome [GO:0042470]; sarcoplasmic reticulum lumen [GO:0033018] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] AEVNRMMKLIINSLYK;EEPEETTEDTTEDTEQDD;EIFLRELISNASD;ETTEDTTEDTEQ;LKVIRKKLVRK;LKVIRKKLVRKTLDMI;LLKVIRKKLVRK;QHKLLKVIRKKLV;QQHKLLKVIRKK;SEFLNKMT;TDTGVGMTREEL;TEDTEQDDEEEMDAGTDDEEQ;TLQQHKLLKVIRKKLV;TLVLKEEASDYLE 14 14.4 1.0022 -0.65418 4.52995 7.19012 11.0961 8.30929 0 7.56514 10.9703 0 0 3.01757 0 0 9.41128 5.64126 11.6426 A0A8P0SCQ4 A0A8P0SCQ4_CANLF Threonine synthase-like 2 THNSL2 Canis lupus familiaris (Dog) (Canis familiaris) lyase activity [GO:0016829] MAHHFFAYFRCAPSL;SESMSDEAITWTMS;SESMSDEAITWTMSRCWEENQY;TLASAMDIQ 4 10.3 0.99148 -0.14839 0 5.1061 0 0 0 8.34687 0 5.04815 0 0 0 0 0 0 0 A0A8P0SCQ5 A0A8P0SCQ5_CANLF Granule associated Rac and RHOG effector 1 GARRE1 Canis lupus familiaris (Dog) (Canis familiaris) LVSSYMDNVMSE;VLGQKPQGP 2 2.2 1.0018 -0.75377 0 0 0 0 0 6.93216 0 0 0 0 0 0 10.2576 0 0 A0A8P0SCQ6 A0A8P0SCQ6_CANLF CCAAT enhancer binding protein gamma CEBPG Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GPGGGGKA;LFLEHAHNLAD 2 12.9 0.98997 -0.26592 0 3.66653 0 0 8.62224 0 0 10.9072 0 0 0 0 10.6535 0 0 A0A8P0SCS3 A0A8P0SCS3_CANLF Pleckstrin and Sec7 domain containing 4 PSD4 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] DEATKGTLEAPGCWT;EGQRPQAGDKLANGVS;GDGTADSSGH;LVGQMVDEPVGVHH;PGGDSSDP;PSPEGWQT 6 7.6 0.98736 -0.22796 0 9.83599 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SCT6 A0A8P0SCT6_CANLF NME/NM23 family member 9 NME9 Canis lupus familiaris (Dog) (Canis familiaris) CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] nucleoside diphosphate kinase activity [GO:0004550] DGCLSHDEDNGEDEDMA;EDNGEDEDMASSGKTCT;VHGSQDRDDASRELALLFPTFKFSD;VLAEGCERKVIR 4 19.1 0.99315 -0.053038 6.80941 0 0 0 4.52863 10.9117 0 0 0 0 0 0 0 7.45047 0 A0A8P0SCT7 A0A8P0SCT7_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] AAEPPRSRGLTPAD;AAGGGGGG;EDDTSYFDTRSEKYHHM;ESTEKKKISGKVT;FPSGTNSSQSSSPSSS;GGGGGGGA;GGGGGGGG;GGRGGGGG;ITSRYFLELQHKLDKLLQ;KYHHMETEEEDDTNDED;LLECLEFDPE;LLQEAHDRSE;PPPPAAQELPGP;TPVPPAPP;VGTPVPPA 15 6 1.0008 -2.7424 0 10.8877 0 0 0 0 12.6862 0 0 0 9.70425 7.27408 7.62936 11.0601 0 A0A8P0SCU9 A0A8P0SCU9_CANLF Centrosomal protein 89 CEP89 Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrion organization [GO:0007005] centriole [GO:0005814]; synapse [GO:0045202] EKDELNATLQEE;GVLNKIIEGNIRLGRLKEKVK;QEDFASKTAQYQQ;SDTICVEKDSFIE;SPDIAGRT;TAQYQQEMRHLHR;TRQRYIEITKEKFEEL;TSELRLQP;VGDISHRLTE 9 12.8 1.0034 -1.5714 0 0 0 8.39849 5.49816 8.13119 11.8615 0 0 0 9.56968 0 0 0 6.80529 A0A8P0SCV6 A0A8P0SCV6_CANLF Glutathione hydrolase (EC 2.3.2.2) (EC 3.4.19.13) (Gamma-glutamyltransferase) (Gamma-glutamyltranspeptidase) GGT7 Canis lupus familiaris (Dog) (Canis familiaris) glutathione catabolic process [GO:0006751] membrane [GO:0016020] acyltransferase activity [GO:0016746]; glutathione hydrolase activity [GO:0036374] DEDAFLGDPDTDPD;ESHLIDFRESAPGALREEALQRSWE;IMGPDDFIV 3 7.3 1.0036 -0.80455 0 0 0 0 0 0 0 9.85435 0 0 0 0 0 0 12.9904 A0A8P0SCW0 A0A8P0SCW0_CANLF Vesicle associated membrane protein 5 VAMP5 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] membrane [GO:0016020] ERCQRQAD;LLIILIVLLVIFL;SDQLLDMSSAFSKT;VGIGLLIILIVLLVI;VGIGLLIILIVLLVIFL;VGIGLLIILIVLLVIFLPW 6 35.3 0.99406 -0.055033 0 0 0 0 0 0 0 4.03694 0 0 6.92362 8.41253 0 0 0 A0A8P0SD03 A0A8P0SD03_CANLF E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181) RNF181 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; transferase activity [GO:0016740] ASYFDEHDCEPL;NRMDFEDLGLV;SLFNRMDFEDLGLVVDWD 3 21.7 0.98707 -0.23025 0 0 0 0 4.88176 0 8.70494 0 0 0 0 0 0 0 0 A0A8P0SD16 A0A8P0SD16_CANLF ELMO domain containing 3 ELMOD3 Canis lupus familiaris (Dog) (Canis familiaris) EDLGFQGANPATDLRGAG;SYLGCPCLDLS;VLKDLEVLAKKSPRRLLKTLEIYL 3 14.2 0.99393 -0.063621 0 0 0 0 0 5.60036 0 0 0 0 0 0 0 0 0 A0A8P0SD24 A0A8P0SD24_CANLF Myosin heavy chain 7B MYH7B Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DMLRNRENQSMLITGESGAG;EAAVLHNLRQRYA;EGDLKLTQESVTDAA;EIKSEATG;GVVPYSIVGWLEKNKDPLN;LLYADFRQRYRI;LSGKKPELQDMLLLSMN;LTDQVSLSGKSIQ;SEATGGRV 9 6.2 1.0031 -1.9327 0 10.6023 0 0 0 9.92985 9.71893 0 0 0 0 0 8.47768 10.4998 0 A0A8P0SD39 A0A8P0SD39_CANLF Olfactory receptor OR5AP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LKKILQKHLL 1 3.2 0.99964 -0.61146 0 0 0 0 0 0 0 0 2.55981 0 0 0 0 0 0 A0A8P0SD45 A0A8P0SD45_CANLF Glycine receptor alpha 3 GLRA3 Canis lupus familiaris (Dog) (Canis familiaris) chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] extracellularly glycine-gated chloride channel activity [GO:0016934]; transmembrane signaling receptor activity [GO:0004888] ETTMDYRVNIFLRQKWNDP;GPCLQAKDGVTPKGPNHPV 2 9 0.93498 0.099056 0 0 0 0 0 5.27877 0 0 8.69982 0 0 0 0 0 0 A0A8P0SD62 A0A8P0SD62_CANLF FACT complex subunit SSRP1 SSRP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; DNA replication [GO:0006260] chromosome [GO:0005694]; nucleolus [GO:0005730] DNA binding [GO:0003677] AGELTEGIWRRVALGHGLKLL;IETKQGTQ;KKKKKVKVK;NDSSDDSGEETDESFNPGEEE;PGNFQGHSGAQCITCSYK;SFDFEIETKQGTQYT;SYDEYADSDEDQH 7 13.9 1.0045 -1.0482 8.03485 11.6624 0 0 5.42092 0 0 0 0 5.85262 0 0 5.73601 0 0 A0A8P0SD69 A0A8P0SD69_CANLF Olfactory receptor OR5G5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IFLLVYLVTLLGNV;VNQFLLFILAGALGVLSGVIILV 2 11.8 0.93358 0.10717 0 0 0 0 0 0 9.12516 0 0 0 0 0 0 0 0 A0A8P0SD86 A0A8P0SD86_CANLF Ubiquinol-cytochrome c reductase complex assembly factor 1 UQCC1 Canis lupus familiaris (Dog) (Canis familiaris) CRIIVHFMWEDVEQRGRVMG;KWKIKIAALRMYTSCVE;VEEKVGAFTKIIE;VGVQWSRKYHTTNKLST;VLVGNKHPVNSYI 5 22.5 0.99233 -0.037583 0 0 0 0 5.74182 11.6464 0 0 7.5274 0 9.13942 0 0 0 7.50867 A0A8P0SD98 A0A8P0SD98_CANLF Olfactory receptor OR5T2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AEGRRKIFSTCGSH 1 4.7 0.98226 -0.24865 0 0 0 0 0 0 0 10.1871 0 0 0 0 0 0 0 A0A8P0SDA1 A0A8P0SDA1_CANLF Olfactory receptor OR5D17 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVTEDRSISFKG 1 3.7 0.98387 -0.24753 0 0 0 0 0 0 0 9.82157 0 0 0 0 0 0 0 A0A8P0SDA3 A0A8P0SDA3_CANLF Olfactory receptor family 5 subfamily T member 8 OR5T8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EISTILIVLVSY 1 3.9 0.98969 -0.26329 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6063 A0A8P0SDB7 A0A8P0SDB7_CANLF Transcription activation suppressor TASOR Canis lupus familiaris (Dog) (Canis familiaris) "negative regulation of gene expression, epigenetic [GO:0045814]" DPNLISMNNFEDC;DTLKDTNSNEQHSS;FQPLTPGSREFE;GGGGGGGG;KLVLVKPL;LHSSYLEPTSV;LQSSPDVQNSLLE;PAAEPPTMSETTER;QNGGGGGG;QPALSNFISQLEPEV;SLDDVKNHTY;SLDSGDEISQIEVCSNFHSE;VLHALFLFQESR 13 9.4 1.0028 -2.5354 0 4.41704 0 8.87547 6.64292 9.44388 3.52293 0 0 0 9.02945 4.39739 9.29996 12.6364 4.27068 A0A8P0SDE2 A0A8P0SDE2_CANLF Olfactory receptor OR4S1 OR4S1B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VGGFLHSILQ 1 3.2 0.99246 -0.27189 0 0 0 0 0 0 0 0 7.6388 0 0 0 0 0 0 A0A8P0SDH3 A0A8P0SDH3_CANLF Cyclic nucleotide binding domain containing 2 CNBD2 Canis lupus familiaris (Dog) (Canis familiaris) DLVRLLVKPRQRPPF;GHFPPKAMQITQ;LDSYRNYLEP;LVRLLVKPRQRPPFIPVRPKKKE;RGFREYQIIETS;SWRTESEIQALCNLLQ;VERFKEFQIKSYPVQDFSS 7 16.2 0.9895 -0.26223 0 0 0 0 0 0 0 0 0 0 9.33351 0 0 0 0 A0A8P0SDI4 A0A8P0SDI4_CANLF Substance-P receptor (NK-1 receptor) (Tachykinin receptor 1) TACR1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] tachykinin receptor activity [GO:0004995] IQQVYLAIMWLAMSSTMYNPI;IYCCLNDRFR 2 7.6 0.9921 -0.19407 0 0 0 0 8.15755 0 0 9.4064 0 0 0 0 0 0 0 A0A8P0SDI6 A0A8P0SDI6_CANLF CDAN1-interacting nuclease 1 CDIN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] GVLANQVYQCIVNDCCYGPLVDC;SHLATRSSARL 2 13.2 0.94358 0.081767 0 7.56628 0 0 0 0 0 0 7.26566 0 0 0 0 0 0 A0A8P0SDI9 A0A8P0SDI9_CANLF AUP1 lipid droplet regulating VLDL assembly factor AUP1 Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811]; membrane [GO:0016020] LLVLRLFLGIHVFL 1 3.8 0.93208 0.060781 0 0 0 0 4.26191 0 0 0 0 0 0 0 0 0 0 A0A8P0SDJ8 A0A8P0SDJ8_CANLF DEAQ-box RNA dependent ATPase 1 DQX1 Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386] HVIDSGLELRSVYNP;LESSPSGVVLVSGEPG;SELAVNPFDGLPFSSR 3 6.5 0.98728 -0.22901 11.799 9.31118 0 0 0 2.95522 10.7398 0 11.7298 0 0 0 0 11.4361 0 A0A8P0SDK9 A0A8P0SDK9_CANLF Guanylate cyclase soluble subunit alpha-1 (EC 4.6.1.2) (Soluble guanylate cyclase large subunit) GUCY1A1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037] IAAVEIVKESLGEE 1 2 0.99564 -0.11655 0 11.0484 0 0 0 0 0 0 0 0 0 0 0 10.878 0 A0A8P0SDN9 A0A8P0SDN9_CANLF Electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) (EC 1.5.5.1) ETFDH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] "4 iron, 4 sulfur cluster binding [GO:0051539]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; metal ion binding [GO:0046872]" HYTIYPRDKDKRWEGVN;LVALGFVGLDYQ;QGDGFRLQINAQNCVHCK;VGIQKDGAPKTTFER;VYEFVPLE 5 11.4 1.002 -0.90695 0 0 0 0 11.9115 0 0 10.1871 0 0 8.47285 0 0 0 0 A0A8P0SDQ1 A0A8P0SDQ1_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 1 ADAMTS1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] GGGAKCGV;GGGGGGGA;GGGGGGGG;KCVNKTDKMH;KHCLDAASTCM;NHRGSRNN;RECDNPVP;RWQLGDWSPC;TLSTLEQDIT 9 8 1.001 -2.726 6.52909 9.09582 0 0 0 5.41254 9.34227 8.84627 17.2342 0 0 0 0 8.90204 0 A0A8P0SDR0 A0A8P0SDR0_CANLF Peripherin PRPH Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] EDAEHNLVLFRKDVDD;EFLATRSNEKQELQE;LTCEVDGLRGTVSPGFAPRGGG 3 11.8 0.85996 0.18203 0 0 0 0 0 0 0 9.2465 0 0 5.79621 0 0 9.68571 9.58858 A0A8P0SDR5 A0A8P0SDR5_CANLF Zinc finger AN1-type containing 1 ZFAND1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ETASKRRK;KEDCPLYNEQLANLL;LPFVCDGCSGVFCLE;SDKPTSYPCSF;TLETWIAKED 5 16.5 1.0033 -1.5752 0 8.77169 0 10.9009 0 0 0 0 0 7.15674 0 0 0 0 9.20858 A0A8P0SDR8 A0A8P0SDR8_CANLF Transketolase (EC 2.2.1.1) TKT Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; transferase activity [GO:0016740] DTKNSTFSEIFRKEH;EAGLPKRSSQ;LAAAELLK;LHEALAAA;QKLQALKDTANRLRISSI;SGHPTSCC;YQKRCESFGWHAVI 7 11.6 1.0034 -2.2198 10.3549 0 0 4.90641 0 0 0 0 7.29792 0 0 4.94064 0 0 10.6963 A0A8P0SDS3 A0A8P0SDS3_CANLF Thrombospondin 1 THBS1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] DACDDDDDNDKIPDDRDNCP;DCVGDATENQICNKQDCPID;DEDGHQNNLDNCPY;GDACDDDDDND;GDACKDDFDHDNVPDIDD;QAAAGAGPSIRVQD;SNATVPDGECCPRCWPSDSAD;SRLPESGGDNSVFDIF;TSYRDGSWKCGTCPP;VGDQCDNCPLEHNPDQLDSD;VGYDEFNAVDFSGT 11 11.9 0.99295 -0.17896 13.036 0 0 0 10.751 6.37933 9.85877 9.49321 7.87406 0 7.74974 7.45459 8.53854 7.26341 0 A0A8P0SDS4 A0A8P0SDS4_CANLF Single stranded DNA binding protein 2 SSBP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] single-stranded DNA binding [GO:0003697] GGMESHHM;RGMVPLGPQSDPWLSLQ 2 7.4 0.98855 0.030021 0 0 0 10.9 10.2227 11.5401 9.0814 10.7318 10.6684 0 0 0 11.2834 0 0 A0A8P0SDT6 A0A8P0SDT6_CANLF Transmembrane protein 116 TMEM116 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] LTFATSPPPSFETV;PSANTSVCSALYFY;TLTFATSP 3 7.2 1.0025 -1.3263 10.0643 0 0 0 0 0 0 0 0 0 0 0 0 9.12554 0 A0A8P0SDU7 A0A8P0SDU7_CANLF RNA helicase (EC 3.6.4.13) DDX23 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] nucleus [GO:0005634] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] DIQDVSMVVNYDM;EAEALKRRQQEVEE;IDLKQQKR;QQEVEERQRMLEEERKKRKQFQDLG;RKMLEDPQERERRERRERMERET;VGEAAVLA 6 10.5 1.0033 -1.0569 0 0 0 5.50557 10.2567 10.6286 10.9613 0 0 11.0372 0 0 0 0 0 A0A8P0SDY1 A0A8P0SDY1_CANLF F-box protein 41 FBXO41 Canis lupus familiaris (Dog) (Canis familiaris) AHSLTLQNLKP;ESLLKAAGGNLLIL;KALLHFNS;PASPSPAD;SPADVAYEEGLAR;SRVPAASQSSGCYDSDSL;SSACSTPP;VGGAGCGV;VSEITQEVAAE 9 10.9 0.99723 -3.8775 0 5.85803 0 0 10.2986 0 0 8.87412 0 11.0562 11.3486 0 11.7008 0 7.62066 A0A8P0SDZ8 A0A8P0SDZ8_CANLF MOB kinase activator 1A MOB1A Canis lupus familiaris (Dog) (Canis familiaris) IEKLGSKDR 1 4.2 0.99196 -0.27195 0 0 0 8.92976 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SE14 A0A8P0SE14_CANLF ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) PFKM Canis lupus familiaris (Dog) (Canis familiaris) fructose 6-phosphate metabolic process [GO:0006002] cytoplasm [GO:0005737] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] ADWVFIPECPPDD;DDDWEEHLC;DTFRSEWSDLLSKITAEEATKSSYL;GLVGSIDNDFCGTDMTIGTDSA;LKLRPILKIL;LKLRPILKILAK;SEWSDLLSKITAEEATKSSYLN;TTCDRIKQSAAGT 8 12 0.99076 -0.22099 0 0 9.89724 0 0 0 0 0 10.4324 0 0 0 0 0 0 A0A8P0SE15 A0A8P0SE15_CANLF Ral GTPase activating protein non-catalytic subunit beta RALGAPB Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] EATLTCIMQLL;GETVKYCVDVYTDWI;LLFLLQINDILLAPPTVQGG;LVTQRLNSQWR;RFTYGPSFPPFK;SEDIGASIFNGQK;TFLSLKLRLVNILIGA;TMKTSTVR 8 7.2 0.98994 -0.26397 0 0 0 0 0 0 0 0 11.2688 0 0 0 0 0 0 A0A8P0SE17 A0A8P0SE17_CANLF Solute carrier family 8 member B1 SLC8B1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816] membrane [GO:0016020] antiporter activity [GO:0015297] GLVPVWAVVVI;IILKSRVGCPTNG;SEEYRPLLFYQETTA;TEVVNILRSLGVVFRLSNTVL;VVAGGIAI 5 12.3 1.0008 -0.92637 11.9205 11.3449 0 0 0 18.1566 0 11.0608 11.1355 10.8242 11.2151 11.2398 11.2141 11.3404 11.6255 A0A8P0SE28 A0A8P0SE28_CANLF KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) KANSL2 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; nucleus [GO:0005634] CQDTNQVLFKCCQGSE;LEAGPMDLYLSAAELQ;TGPEGLLA 3 8.4 1.0034 -1.0358 0 0 0 0 0 0 0 0 0 0 7.78581 7.62688 11.5888 10.9562 7.07671 A0A8P0SE45 A0A8P0SE45_CANLF Neurofilament light polypeptide (Neurofilament triplet L protein) NEFL Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; cytoplasm [GO:0005737]; intermediate filament [GO:0005882] AAISNDLKSIRTQ;ISVEMDVSSKPDLSAALKDIRA;QGEREGLEET;RYEEEVLSREDA 4 10.5 0.99387 -0.1722 0 0 9.99223 0 0 7.9794 0 0 9.02428 0 7.76215 9.48551 0 0 0 A0A8P0SE50 A0A8P0SE50_CANLF Fibronectin type-III domain-containing protein IFNAR1 Canis lupus familiaris (Dog) (Canis familiaris) endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] NTSPWHNIDSFTLFEKAQIG 1 8.7 0.98506 -0.25919 0 0 0 0 0 8.33275 0 0 0 0 0 0 0 0 0 A0A8P0SE52 A0A8P0SE52_CANLF RNA binding motif protein 12B RBM12B Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DEDFRGPPDEDFRQP;DFFHGYRILPDSVSIQ;EDDFRRLPQGE;EDFRRPPEEDFRRL;EDFRRPWEEGFRY;EEDFRSPQEEDFRGPSDEDF;LLGLPFIAGPVDIRH;PDSVSIQYNEQG;PKLNCSSGRVTPIKIM;RLNRRRFL 10 13.4 1.0018 -0.66183 0 6.74927 0 0 11.4261 0 0 9.57274 11.8498 9.90944 12.4048 0 0 6.64381 7.22391 A0A8P0SE58 A0A8P0SE58_CANLF Otogelin OTOG Canis lupus familiaris (Dog) (Canis familiaris) L-arabinose metabolic process [GO:0046373] alpha-L-arabinofuranosidase activity [GO:0046556] CCPSYSCECDP;DSCCPSYSCECDPDLCEAE;DSCCTSYFCACGDCPDPI;DVTWFYSNCLTDTCGCSRGGDC;GDCECFCASVSAYAHQCCQHGVAVD;HPCASTCTAYGDRHY;LCVPRNQCSCHFQGMDYPPGDSD;LDEVTQRCVYLE;LGHCHCKDGV;LSSALPLI;LVLRLYEHT;NKALGKGP;PFLCSSDSIYQACVA;PPDTYLDT;PRFGEVALLLPTEDP;PSLGHCHC;PVTCGAGG;QEDSCCPSYSC;RTFSACHRFVPPESFCELWIR;SAPAQSIAASSAVTVTPIAEQ;SCSVLTGELFAPCSAYLSP;SGSPSPESFLDEK;SLHPCASTCTAY;SPGEAEVL;TSYFCACGDC;VLDSLAMSSWERR;VPACALSCEATKEYSPCVALCG;VTASNLPAHPTEPPA;VTPIAEQDCVRHICL;WIRDTKYVQQPCVALTV 30 12.9 0.99678 -7.7106 9.6871 10.2569 9.7339 10.0293 6.62501 8.65664 10.1267 10.2421 0 0 12.745 9.71277 9.77806 3.61777 9.15848 A0A8P0SE66 A0A8P0SE66_CANLF Kinetochore scaffold 1 KNL1 Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; protein localization to kinetochore [GO:0034501] DLLDCTKSEKSIKIDTASF;DTTDLNHLEIQP;EETYCEITGMNTLL;EIAETEAGENVL;NELRKNTKCNTDFHSN;RTVSIDKLDT;SKLPEPLRKGVG;THTSTQTSNQD;TVSIDKLDT 9 5 1.0031 -1.6583 0 10.3053 11.0777 0 8.54017 0 11.261 0 9.54844 0 0 0 0 0 6.43243 A0A8P0SE77 A0A8P0SE77_CANLF Round spermatid basic protein 1 RSBN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] DFVLKKIKKKKKKKH;FNFPNTPVKMEILGKK;IHEEHQSNGGAL;KKIKKKKKKKH;VLKKIKKKKK;VLKKIKKKKKK;VLKKIKKKKKKK;VLKKIKKKKKKKHREDMRGRRLKM 8 7.2 1.0011 -0.63879 0 0 0 7.23276 0 4.65065 0 0 0 3.28551 0 0 8.29692 0 7.06867 A0A8P0SE91 A0A8P0SE91_CANLF "Isovaleryl-CoA dehydrogenase, mitochondrial (EC 1.3.8.1) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase)" IVD Canis lupus familiaris (Dog) (Canis familiaris) L-leucine catabolic process [GO:0006552] flavin adenine dinucleotide binding [GO:0050660]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937] KAEKKGDYYIL;LSYGAHSNLCL;PAANILGHLSKGVYVL;TTDHTDSM 4 8.1 1.0032 -1.9409 0 0 0 0 9.87311 0 0 0 0 0 0 0 7.68047 0 0 A0A8P0SEB3 A0A8P0SEB3_CANLF Ankyrin repeat domain 2 ANKRD2 Canis lupus familiaris (Dog) (Canis familiaris) GGIQNLIELRKKRKQKKREA;KIIKLLLLH;KLPMDMLVLEDE;LIELRKKRKQKKREALAAAQEP;RTGHVEIVQHFLS 5 18.2 1.0024 -1.1686 0 0 0 0 0 0 3.23357 0 0 0 9.2914 9.67296 0 0 9.67182 A0A8P0SEC7 A0A8P0SEC7_CANLF SR-related CTD associated factor 11 SCAF11 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EDLLSAKLND;EDNNEMIPMECDSFCSDQ;ESEEHTEN;HVSNNMSTPVLPA;IPMECDSFCSD;IPSASHVSN;LVKAYIDKKKKLIK;NESFKFVE;NSMQDSRSNL;RGRGNRGRGTYRGGFA;SPRWKERWANDGWRCPRGNDRYR;SVRRGRKPPLLKKKL;TVDKKSIESSEVQLLGH 13 10.9 0.99894 -3.2443 10.4894 0 8.07489 7.76997 0 7.76015 0 10.221 9.84127 0 0 0 10.7688 10.722 9.01173 A0A8P0SED4 A0A8P0SED4_CANLF Nischarin NISCH Canis lupus familiaris (Dog) (Canis familiaris) integrin binding [GO:0005178]; phosphatidylinositol binding [GO:0035091] AGEVFAIGPLQLY;AGGCQERSQ;EGQGEQGEDDDDDEEDA;GRGEEEEEEEEEEEEEG;IEQMEEVRSI;LVEGQPPEDRASN;QGEQGEDDDDDE;VTLDHFGEVPGGPARAGQGREV;YAVTEQLQQGKPTCA 9 7.4 1.0026 -1.1817 0 0 9.27408 8.33159 0 0 10.3297 0 7.53364 0 0 0 8.63739 9.88602 0 A0A8P0SEG6 A0A8P0SEG6_CANLF AKT-interacting protein AKTIP Canis lupus familiaris (Dog) (Canis familiaris) YKIDTASPLNPEAAVL 1 5.5 0.99273 -0.069603 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.962 A0A8P0SEH5 A0A8P0SEH5_CANLF Ganglioside induced differentiation associated protein 1 like 1 GDAP1L1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYWYLKKK;KILEHDDVSYLKKI;MVLDQIEAELEKRKLENEGQKCEL 3 12.5 1.0036 -1.0682 10.4576 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SEJ7 A0A8P0SEJ7_CANLF Adhesion G protein-coupled receptor G7 ADGRG7 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] INNIVIFI;QNKASEVLKSLSLSTGRVKLK;SAAAATDYDDTFAT;TIILINNIVIFIIIIVKVI 4 6.8 1.001 -0.94386 0 8.17488 0 0 6.81031 6.06676 0 8.49593 0 5.00009 6.88521 0 0 0 0 A0A8P0SEK6 A0A8P0SEK6_CANLF Synaptotagmin 6 SYT6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RQTTEPASSTRHTSFKRHLPRQMH 1 5.7 0.97334 0.041303 0 0 8.97588 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SEL5 A0A8P0SEL5_CANLF Carboxypeptidase N subunit 1 CPN1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] EITLELSCNKFPRQE;LSCNKFPRQEELQR;VTFRHHRYDDL 3 6.7 0.99762 -0.10392 0 0 9.01058 0 0 0 10.0139 0 0 0 0 0 0 0 0 A0A8P0SEN5 A0A8P0SEN5_CANLF Fibroblast growth factor (FGF) FGF17 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] KFAKLIVE;NHPSPNFNQYVR 2 9.3 1.0041 -1.0539 0 0 0 0 8.53699 0 0 0 0 0 0 0 5.37504 4.92728 0 A0A8P0SEQ2 A0A8P0SEQ2_CANLF Immunoglobulin superfamily member 3 IGSF3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEGQYECHV;EGSHITIWCNVSGYQ;FAHREARGQLKVA;FVFFYPFPI;GEQEEEGDEEEEEDPTERM;PGVTYSDSFDLQCI;QNVAVQDSGTY;SSISVEVASNASVILEGENLHFS;VILEGENLH 9 9.5 1.0029 -2.4671 0 0 0 0 9.93394 0 7.01859 12.0055 10.7964 0 0 0 0 0 6.11909 A0A8P0SER4 A0A8P0SER4_CANLF CD58 molecule CD58 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILVVVIIIAIVTVLLI;LVVVIIIAIVTVLLIKV;LVVVIIIAIVTVLLIKVYLK;WAILVVVIIIAIVTVLLIKVY 4 9.2 0.85325 0.19083 0 0 0 4.4518 4.98204 0 0 0 6.59805 5.64927 0 0 9.75368 0 0 A0A8P0SER8 A0A8P0SER8_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G4B Canis lupus familiaris (Dog) (Canis familiaris) phospholipid catabolic process [GO:0009395] cytosol [GO:0005829] calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]; phospholipase activity [GO:0004620] LSDQREALSHGQNPLPIYC;NLSSSDSP;VGTLQAGEF;YHYSKVTYSPEDMD 4 6.4 0.98996 -0.26657 7.05246 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SES6 A0A8P0SES6_CANLF Holocarboxylase synthetase HLCS Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077] GVAFMEDRLQMAD;LSILSSGFVYEDCSG;YLLPVAEEILDP;YVGSTPQESLGRFQEVRSVLA 4 7 0.87025 0.14189 0 0 0 0 0 0 7.11061 0 11.3285 0 10.2049 0 10.8157 0 0 A0A8P0SES7 A0A8P0SES7_CANLF Stearoyl-CoA desaturase SCD Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] "oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [GO:0016717]" FLCFPPVQ;ILLRPGFLCFPP 2 3.9 0.99007 -0.21254 0 0 10.7419 0 0 0 0 0 10.9218 0 0 0 0 9.16405 0 A0A8P0SET2 A0A8P0SET2_CANLF Dynein axonemal heavy chain 5 DNAH5 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] FAKVWFSE;FYYQDMEVAETGQLGSP;IDWFSRWPKD;IPTLINAIKMIY;ITPENIHWEVSFNML;LYFLITEMRLVNEMY;MSSTPLCQLPQEEPLTCAEFLQ;RCLGKYVV;SEEADAEMP;SISSREGETIELDKPVMAEGNV;TTEVHKHFPITL;VLEEMSSTPLCQ;VRDSVMKLIPLTRRL 13 3.6 1.0031 -2.452 0 0 10.4903 7.92011 0 7.75475 0 7.01759 9.19476 6.88289 10.294 0 0 7.98721 0 A0A8P0SEV2 A0A8P0SEV2_CANLF Muscarinic acetylcholine receptor CHRM3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of smooth muscle contraction [GO:0045987]; saliva secretion [GO:0046541] lateral plasma membrane [GO:0016328]; postsynaptic membrane [GO:0045211] G protein-coupled acetylcholine receptor activity [GO:0016907] GPLDAGLPPGTVTHFGSYNISQA;LDAGLPPGTV 2 3.9 0.98811 -0.48588 8.29043 0 0 0 0 0 0 9.83194 0 0 0 0 0 0 0 A0A8P0SEW2 A0A8P0SEW2_CANLF Potassium inwardly rectifying channel subfamily J member 15 KCNJ15 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion channel complex [GO:0034702] inward rectifier potassium channel activity [GO:0005242] EPSEDVSNHTPCIMKVDSLTGAF;LFGVIYYAIAFIHGDLEPS;LPMTFYHVLDETSPL;SGHSNVRI;SLTGAFLFSLESQ 5 18.4 1.0024 -1.1236 10.0258 0 9.33976 0 0 0 0 0 10.9774 7.92825 8.12221 0 0 9.38534 8.77057 A0A8P0SEW3 A0A8P0SEW3_CANLF Sorting nexin family member 21 SNX21 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] early endosome membrane [GO:0031901] phosphatidylinositol binding [GO:0035091] AEDEEDEDDEDD;AQISRRYSDFERLHRNLQR;LSFTSAEDEEDEDDEDD;SAEDEEDEDDEDDGEVGPDPL;SFTSAEDEEDEDDEDDG 5 12.1 0.98677 -0.3821 0 0 6.44738 0 0 0 8.83656 9.52724 0 0 0 0 5.3618 5.53733 3.53928 A0A8P0SEX1 A0A8P0SEX1_CANLF GMP reductase (GMPR) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase) GMPR Canis lupus familiaris (Dog) (Canis familiaris) purine nucleobase metabolic process [GO:0006144]; purine nucleotide metabolic process [GO:0006163] GMP reductase complex [GO:1902560] GMP reductase activity [GO:0003920]; metal ion binding [GO:0046872] ISDGGCTC 1 2.5 1.0036 -1.1044 0 0 0 0 5.50516 0 0 0 0 0 0 0 0 0 0 A0A8P0SEX6 A0A8P0SEX6_CANLF U3 small nucleolar RNA-associated protein NOL7 C-terminal domain-containing protein NOL7 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] KTLLKEKRKRRE;LEEDDDEDGDDEL;SYLAVRLKDQDLR;SYLAVRLKDQDLRD 4 15.8 0.91782 0.11024 0 0 0 3.58892 0 0 0 0 0 0 0 0 0 4.00315 0 A0A8P0SEY6 A0A8P0SEY6_CANLF Oxidoreductase HTATIP2 HTATIP2 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525] membrane [GO:0016020]; nuclear envelope [GO:0005635] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" NFLYLQVKGE 1 3.4 0.93363 0.068222 6.27122 0 0 0 0 0 7.19417 7.0677 0 0 0 0 0 0 0 A0A8P0SEZ0 A0A8P0SEZ0_CANLF Sperm associated antigen 17 SPAG17 Canis lupus familiaris (Dog) (Canis familiaris) AAHLAELFKQSLPT;DELHPDCQQDSE;EDYSSEDV;KNQKNFDPVQIEQEMQSK;LEGSLKAWK;LMYDTLDWKRQHQH;LPVEATVL;NCEDSSCCATFGD;SKEPLDPDNIEL;VPKGPLLL 10 5.2 0.99903 -2.9296 9.76603 0 2.38339 0 0 9.25054 0 0 11.099 0 0 0 10.5256 0 9.40359 A0A8P0SEZ8 A0A8P0SEZ8_CANLF MAGE family member L2 MAGEL2 Canis lupus familiaris (Dog) (Canis familiaris) ETPKSLPLALQ;GDWEGPSTSRGLSGWEG;ITQPAASGAPMAQPAAPPAQ;LDEDEPGSGD;QGPPPIRPG;SPGWQAPPQGWQ 6 6.7 1.0039 -0.82491 0 0 0 0 0 0 10.0097 9.54003 0 0 0 7.21023 0 0 0 A0A8P0SF09 A0A8P0SF09_CANLF Twinfilin actin binding protein 2 TWF2 TLR9 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] cytoskeleton [GO:0005856]; perinuclear region of cytoplasm [GO:0048471] actin binding [GO:0003779] YHFFLYKHTHEGDPLESVVFIYSM 1 6.9 0.97209 0.041303 7.60058 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SF13 A0A8P0SF13_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GVGSGSPYPQTLSPG;SGSGNFGG 2 12.3 0.94936 0.053907 0 0 0 0 0 0 0 0 8.78944 0 0 0 0 0 0 A0A8P0SF14 A0A8P0SF14_CANLF "Mucin 5B, oligomeric mucus/gel-forming" MUC5B Canis lupus familiaris (Dog) (Canis familiaris) AEGCFCPDGHTL;ATLPSSPRTTQRVPTSTTQTFPS;CHFYAICNQHCDI;CQDCMCHPGSMSVQC;DPCDFYFECECSCRGWGDSH;EAQAMEHQCTCC;ENDPCDFYFECECSCR;FCCSHDHCEQP;GLICRNQD;GLVCRNQEQVGLFKMCYNY;GPSSPATSHRLTVS;GVSGGEFE;GVTTSTTQTGPSSSGT;LETLVTATTEATSS;LPEGLVCRNQDQDDWLKMCLNY;QCGCYDEDGNYHDVG;SAPTTPTSTPC;SENDPCDFYFECECSCRGW;TAASSTGI;TTQGVTVSTTQTG;TTSCQPQCEWTDWFDV;TWTDWFDEDYPV;VGLFKMCYNYRIRV;VLTHQGCTTH;YFECECSCRGWGDSHYTT 25 8.4 0.99774 -3.3883 9.90179 7.47978 10.3382 8.49349 11.0119 6.67539 0 15.3217 0 9.68352 9.99223 7.15391 0 9.73569 11.5235 A0A8P0SF21 A0A8P0SF21_CANLF Carboxymethylenebutenolidase homolog CMBL Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829] hydrolase activity [GO:0016787] QDIFGWQLPNTR 1 4.9 0.95673 0.05044 0 0 0 0 8.05534 0 0 0 0 0 0 0 0 0 0 A0A8P0SF22 A0A8P0SF22_CANLF Gamma-aminobutyric acid type A receptor subunit alpha5 GABRA5 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] AAKVKKKERELILNK;LLFCISMNLASHFG;TVILSQVSFWLNRESVP 3 9.9 0.95303 0.053874 0 0 0 0 0 0 0 0 0 2.76579 0 0 0 0 0 A0A8P0SF36 A0A8P0SF36_CANLF Nucleosome assembly protein 1 like 4 NAP1L4 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] AHIEAKFYEEVHDLERKY;AIEDDDNFEEGEEGEEELEG;EDDDNFEEGEEGEEEL;VLYFTGEAIEDDD 4 12.1 0.86509 0.14575 0 0 0 0 0 0 10.0062 0 0 0 0 0 8.47573 8.06323 0 A0A8P0SF55 A0A8P0SF55_CANLF DDB1 and CUL4 associated factor 1 DCAF1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] nucleus [GO:0005634] AEGEFFIHDAEI;AIVLRRLRELQLQE;DDDEDDDDTDDLDELD;DEDDDDTDDL;EDQEEEEQEEEDDDEDDDD;EEDDDEDDDDTDDLD;EEEDQEEEEQEEEDDDED;EEEDQEEEEQEEEDDDEDD;EEEQEEEDDDEDDDDTD;EEEQEEEDDDEDDDDTDD;EEQEEEDDDEDDDDTDD;EGEDGEDEDSDADEEV;EQEEEDDDEDDDD;EQEEEDDDEDDDDTDDLDEL;ESFRKAKQ;GRTWYLSLPGRAD;HLASLLLHNKF;LNMDTVCRLYEV;LVNAYVMTSRE;QEEEDDDEDDDDT;QEEEDDDEDDDDTD;QEEEDDDEDDDDTDD;QEEEDDDEDDDDTDDLDEL;RQRLAEDEDEEEDQEEEEQEEEDD;SQSPAIKKQLDRHLPSPPTL;VGRQRLAE;VIENQGSM;YYLSYNQDAMERVCMHPH 28 12.3 0.94246 0.05962 0 0 0 0 10.0755 0 0 0 0 0 0 0 0 0 0 A0A8P0SFA2 A0A8P0SFA2_CANLF Methionine aminopeptidase (EC 3.4.11.18) METAP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosolic ribosome [GO:0022626] initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] DHAVHLACIARNCYP;IVNVDITLYR 2 6.5 0.98833 -0.2646 0 0 0 0 0 0 0 0 4.89472 0 0 0 0 0 0 A0A8P0SFB1 A0A8P0SFB1_CANLF PTPRF interacting protein alpha 4 PPFIA4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DENFDHNTLA;DLRKHRRKLL;DTEIQREIGISNALHR;IKSSIGRLFGKKEK;NIEEHLRQLEGQLE;PGTCRSCWRWRSRSCSRRCARRR;RSCWRWRSRSCSRRCARRRRCPRWR;SRSGSAADVRFSLGTAPHA;STELRAEEIETR 9 14.2 0.94578 0.081821 0 0 0 6.22516 0 0 0 0 0 0 4.63686 0 0 0 0 A0A8P0SFB4 A0A8P0SFB4_CANLF SRP receptor subunit alpha SRPRA Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] signal recognition particle receptor complex [GO:0005785] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal recognition particle binding [GO:0005047] ELSKEELIRRKREEFIQKHG;KHRTGFCSHYL;TNIFQSRKPV 3 6.7 1.0019 -0.90705 0 0 0 0 0 0 0 0 0 11.424 0 0 0 0 0 A0A8P0SFC0 A0A8P0SFC0_CANLF Potassium inwardly rectifying channel subfamily J member 1 KCNJ1 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702] inward rectifier potassium channel activity [GO:0005242] MFKHLRKWFI;TERMFKHLRKWFIAHFFGHSR 2 5.4 0.99084 -0.26798 0 0 0 0 0 0 0 0 6.73512 0 0 0 0 0 0 A0A8P0SFF2 A0A8P0SFF2_CANLF Notch receptor 2 NOTCH2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to tumor cell [GO:0071228]; developmental growth [GO:0048589]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235] calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023] ACQWDGGDCSLTMEN;AEGPAAAS;CDEACNSHACQWDGGD;CDQGCNSEEC;CEMDINECHSDP;DCEDDIDDCL;DVNGFRCLCPEGPH;GSYQCQCPQGFTGK;GVHCENNIDECTESSCFN;LDKIGGFTCLCMPGF;LGGAGPSF;LLDEYNVTPSPPGTVLTS;QGNSKTCKYDKYC;QGSYMCECPPGFSGMDCEDDIDDC;SGMDCEDDIDDC;TCRCALGFTGD;VNGWSGDDCSE;VVIILFIILLGVIMAKRKRKHGSL 18 8.2 0.99899 -3.2376 10.2999 6.82005 9.06288 4.00746 9.19402 5.60036 11.5773 10.3288 7.32202 11.0114 8.98396 0 6.64731 0 0 A0A8P0SFG5 A0A8P0SFG5_CANLF Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) YARS2 Canis lupus familiaris (Dog) (Canis familiaris) tyrosyl-tRNA aminoacylation [GO:0006437] ATP binding [GO:0005524]; RNA binding [GO:0003723]; tyrosine-tRNA ligase activity [GO:0004831] GGMSLAEFLYQVLQ;LPEIDHIMQLH;TSPFELYQFFV;VYCGFDPTADSL 4 11.4 0.98662 -0.42484 0 0 0 0 0 8.03875 0 0 0 0 0 0 0 0 9.79142 A0A8P0SFH3 A0A8P0SFH3_CANLF GPI inositol-deacylase (EC 3.1.-.-) PGAP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] "hydrolase activity, acting on ester bonds [GO:0016788]" GVDLSWKAE;ILLTYLYYVFKIVHLQ;PAIISDLTGTS;VLTSQSMCFPLVS 4 5.5 1.0027 -1.128 10.9978 0 0 0 0 0 9.07791 0 5.95278 8.27188 0 0 0 0 0 A0A8P0SFI3 A0A8P0SFI3_CANLF Solute carrier family 17 member 4 SLC17A4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSTSMVSLALSSTTTFC 1 4.1 0.97739 0.04739 0 0 0 0 0 0 0 0 0 0 0 0 0 7.37295 0 A0A8P0SFJ3 A0A8P0SFJ3_CANLF Sortilin related VPS10 domain containing receptor 3 SORCS3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPEMESSI;GGGGGGGG;ISENPYSSGRI;KDIAVHEYFQSQLLS;PGGGGGGG;TRVIGGIA 6 4.5 1.0033 -1.1044 0 0 0 0 0 0 5.77566 6.44713 5.8474 0 0 0 0 0 0 A0A8P0SFJ4 A0A8P0SFJ4_CANLF Nucleolus and neural progenitor protein NEPRO Canis lupus familiaris (Dog) (Canis familiaris) FLLTVKHLGLQ 1 2 0.99452 -0.15274 0 0 0 7.69565 0 0 0 10.1205 0 0 0 0 0 0 0 A0A8P0SFM9 A0A8P0SFM9_CANLF Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) GAP43 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of growth [GO:0040008] cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium membrane [GO:0031527]; growth cone membrane [GO:0032584]; perikaryon [GO:0043204]; synapse [GO:0045202] calmodulin binding [GO:0005516] EDAPAKEEPKQ;FAQGVEKND 2 6 1.0031 -1.0285 0 0 0 0 0 0 0 8.55827 11.1397 0 0 0 0 0 0 A0A8P0SFN9 A0A8P0SFN9_CANLF Solute carrier family 12 member 7 SLC12A7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium:chloride symporter activity [GO:0015379] ALVFLACV;EQESFCEGKNM;FVVIPAAGRAG;GVILFLRLTWIVGAAGV;NHSEMEQESFCE;QVDDNSIQMKKDLQVFLYH;RMRIFTVAQVDDNSIQ 7 7.1 0.81061 0.21373 13.2165 13.1682 13.1816 10.9134 13.3737 8.28411 13.5957 6.76977 13.7356 0 0 6.71685 7.96243 13.3573 8.36672 A0A8P0SFQ4 A0A8P0SFQ4_CANLF LisH domain-containing protein ARMC9 ARMC9 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737] DDDEDEDDEFSAPTHSLWP;DEDEDDEFSA;GVLESDDDEDEDDEFSAP;LLDGVLESDDDED;SEVVRQYMARLI 5 6.1 0.99095 -0.51373 0 0 0 5.41775 0 0 0 0 0 0 0 0 0 0 8.02076 A0A8P0SFR8 A0A8P0SFR8_CANLF Olduvai domain-containing protein LOC100683958 Canis lupus familiaris (Dog) (Canis familiaris) LDRQSLESVAQLYNENR 1 6 0.98201 0.046227 0 0 0 0 0 0 0 0 0 0 0 5.85514 0 0 0 A0A8P0SFS9 A0A8P0SFS9_CANLF Centromere protein E CENPE Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] EIHDKSEELYIITSER;IAVPIIDSAIQGYNGTIFAYGQ;LEEMRSVTKERDDL;LENSNAKLQEKTLFFML;LESREKGE;NQRSSRSHTIFRMILE;NTHFDIEKLKNGIQ;QRNIFSLIQEKNELQRMLE;SEKTDEIANM;SELEQLKEQL;TPVSFDET;VSETQEKICE 12 6.3 1.0034 -1.6335 0 9.08449 0 0 0 0 0 11.2236 11.1262 10.1866 10.133 0 11.4992 0 0 A0A8P0SFU0 A0A8P0SFU0_CANLF Butyrophilin subfamily 1 member A1 BTN1A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DPSMKNVTCY;SYEEASVHLQVAALG 2 4.8 0.99356 -0.55755 0 6.19208 0 0 0 0 0 0 0 0 0 0 0 9.86126 0 A0A8P0SFU3 A0A8P0SFU3_CANLF Coiled-coil domain containing 127 CCDC127 Canis lupus familiaris (Dog) (Canis familiaris) WNYALLVP 1 3.1 1.0034 -1.1044 9.25941 0 0 0 0 6.17463 0 0 0 0 0 0 0 0 0 A0A8P0SFV5 A0A8P0SFV5_CANLF Solute carrier family 24 member 4 SLC24A4 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transmembrane transport [GO:0070588] membrane [GO:0016020] antiporter activity [GO:0015297] ELEDGNDYCDSSSDDPSVPL;KWVFTWPLIFLLCITIPNCSKPRW;LHLSEDVAGATFMAAG;PAIHEFPT 4 12.2 1.0021 -1.0149 0 0 0 0 0 0 0 0 0 7.75442 0 0 7.55436 0 0 A0A8P0SFV6 A0A8P0SFV6_CANLF 26S proteasome non-ATPase regulatory subunit 1 PSMD1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of protein catabolic process [GO:0042176] "proteasome regulatory particle, base subcomplex [GO:0008540]" enzyme regulator activity [GO:0030234] FRNKVLRVLVKIYMN;ICFDLYESASQQFL 2 3.3 0.92086 0.1148 0 0 0 7.75482 0 0 0 0 0 0 0 0 10.133 0 0 A0A8P0SFW3 A0A8P0SFW3_CANLF DNA-directed RNA polymerase III subunit RPC9 CRCP Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] RNA polymerase III complex [GO:0005666] nucleotide binding [GO:0000166] YWRGYPTTTETLKYISKTPCRHQTP 1 15.5 0.97457 0.035538 0 0 0 0 0 0 9.8418 0 0 0 0 0 0 0 0 A0A8P0SG05 A0A8P0SG05_CANLF Serine protease 16 PRSS16 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type exopeptidase activity [GO:0070008] ESALLIPSASHC;LDVAQLRFLSSRHALADV;VLSITQASGP 3 7.7 0.9911 -0.51369 0 0 0 6.13771 0 9.00512 0 0 0 0 0 0 0 0 0 A0A8P0SG14 A0A8P0SG14_CANLF Rho guanine nucleotide exchange factor 38 ARHGEF38 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] ESYEKEEELKQ;KDKLSKLNIHSISKKSKRVTN;LTFLRPRLYMLERRKTDTVVD;NVNINEFKRRKDLVLKYK;QLVEELQVFNRAARKIL;SVTGTPESSISDSSSS 6 13.5 0.99339 -0.063334 4.70061 8.75652 0 0 0 0 0 0 0 0 0 4.66721 0 0 5.98793 A0A8P0SG19 A0A8P0SG19_CANLF Olfactory receptor family 8 subfamily B member 58 OR8B58 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KIALSKTLKKRVF;LFNLSFIDFCYSSVII 2 9.4 0.99295 -0.17055 0 0 0 0 0 0 0 0 0 0 8.59358 0 14.6595 0 0 A0A8P0SG25 A0A8P0SG25_CANLF H15 domain-containing protein H1-3 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527] AAVTKKVAKSPKKAKAAK 1 8.3 0.97214 0.048313 0 0 5.11869 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SG34 A0A8P0SG34_CANLF Endothelin converting enzyme like 1 ECEL1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DEESEKILAAYRV;GGGGGGGE;GGGGGGGG;QFEEFGRAFHCPKDSPMN 4 5.3 0.99006 -0.21224 0 0 0 0 0 0 0 0 0 0 0 9.25486 0 0 11.5519 A0A8P0SG36 A0A8P0SG36_CANLF Testis expressed 44 TEX44 Canis lupus familiaris (Dog) (Canis familiaris) APGGSGPP;EQQDVDQASVDSVTSKPTSAS;PSVAPGGSGP 3 8.7 1.0031 -1.6683 4.09483 0 7.40156 0 0 0 9.88382 0 0 7.77109 0 9.99308 0 0 5.45441 A0A8P0SG45 A0A8P0SG45_CANLF Carboxylesterase type B domain-containing protein NLGN4X Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; synapse assembly [GO:0007416] plasma membrane [GO:0005886] carboxylic ester hydrolase activity [GO:0052689]; neurexin family protein binding [GO:0042043] EVAWSKYNP;HAQYGSPTY;RKTLVALFTDH 3 3.6 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 9.52083 0 A0A8P0SG46 A0A8P0SG46_CANLF Collagen type IV alpha 5 chain COL4A5 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; collagen trimer [GO:0005581]; membrane [GO:0016020] extracellular matrix structural constituent [GO:0005201] FPGQKGEKGH;IPHCPHGWDSLWIGYSFMMHT;NGGIKGERGNPGQPGQPGLPG;PGLKGLPGLPGPQ;PGLMGPPGPPGLPGPKG;SPGPPGVP 6 5.9 1.002 -0.99472 0 0 7.50922 7.21616 8.5016 0 8.72346 0 0 0 0 0 0 6.25374 9.25652 A0A8P0SG56 A0A8P0SG56_CANLF Zinc finger NFX1-type containing 1 ZNFX1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] helicase activity [GO:0004386]; zinc ion binding [GO:0008270] EEEEEGEEEGALIEIP;LEGIYKCQ;PCIRECPPCQRTCQNRCVHS;PWSDENFQQWRTPHQK;QEGKSHQNQHEARFVVE;RGIVQLSFNEQSQQLLAEVQ;SQENDARRRNGNQEG;TFAGVKVHVVDK;VISDCGGAMQRGTCPDC 9 7.4 0.99131 -0.14748 11.2033 0 6.78712 0 10.4321 6.10461 7.55643 0 0 0 0 0 0 0 9.90008 A0A8P0SG72 A0A8P0SG72_CANLF "Unc-93 homolog B1, TLR signaling regulator" UNC93B1 Canis lupus familiaris (Dog) (Canis familiaris) toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] Toll-like receptor binding [GO:0035325] EEERRYYRRKRLGVLKNV;EGEHGGGG;GEHGGGGG;GGGGGGPG 4 5 1.002 -1.3213 9.20286 0 0 4.24557 0 0 0 0 0 8.92128 0 0 0 0 0 A0A8P0SG75 A0A8P0SG75_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HYFCDISPLLNVSCEDSSQ;VISPKMLVDFLSHDKTIS 2 11.4 0.98526 -0.43841 0 0 10.7869 0 13.6869 0 0 0 0 0 0 0 0 0 0 A0A8P0SG87 A0A8P0SG87_CANLF Sodium channel protein SCN1A Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248] ETMWDCMEVAGQAMCL;IRLARIGRILRLIKGA;LEDLDPYYI;PLSEDDFEMFYE;RVIRLARIGRILRLIKGAK;SEGSTVDIGAPAEEQ;SELGAIKSLRTLRALRPLR;TLIEFDWKSYI;TTTETEMRKRRSSSFHVSMDFLE;VEHNWFET;VIRLARIGRILRLIKG;VIRLARIGRILRLIKGAK;VIRLARIGRILRLIKGAKGIRTL;VIRLARIGRILRLIKGAKGIRTLL;VLRSFRLLRVFKLAKSWPTLN 15 7.9 0.98625 -0.41186 0 14.062 14.2111 0 0 0 0 0 6.41507 11.7082 0 0 0 0 0 A0A8P0SG98 A0A8P0SG98_CANLF Transmembrane protein 134 TMEM134 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVSSAIFFVPG;SGVSSAIF 2 6.5 1.003 -1.3336 0 0 0 0 0 0 0 0 0 0 0 10.1673 0 0 0 A0A8P0SG99 A0A8P0SG99_CANLF Nucleoside diphosphate-linked moiety X motif 17 NUDT17 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] ELWEESGLQLPQGQF;QESQQQLQARIQPNPSEVSA;VPLGLWESAYPPRLSWGLPKYH 3 19.3 0.85607 0.15196 7.5818 0 0 8.25167 0 0 0 0 0 0 0 0 5.45362 9.41699 0 A0A8P0SGB4 A0A8P0SGB4_CANLF Retinal pigment epithelium-derived rhodopsin homolog RRH Canis lupus familiaris (Dog) (Canis familiaris) phototransduction [GO:0007602]; pseudouridine synthesis [GO:0001522]; ribosome biogenesis [GO:0042254]; visual perception [GO:0007601] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881] DQGPPEHVVLLGEFL;PYFNAPVYLENKEQIGKVDEIF;TDENKVPYFN;TSILPMDVSQNPL 4 14.9 0.98642 -0.25969 0 0 0 0 11.7825 0 0 0 0 0 0 0 0 0 0 A0A8P0SGD9 A0A8P0SGD9_CANLF Olfactory receptor LOC488617 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LACTDTSLVVIV 1 4 0.98958 -0.26329 0 0 0 0 0 0 11.6885 0 0 0 0 0 0 0 0 A0A8P0SGG0 A0A8P0SGG0_CANLF CD1c molecule CD1C CD1E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AYEGSDFVTF;EQQGTQRGDILP;GEAGDMGAAGHQAGAT;PLECILLAALLL;SGTIIFLHTWSKGNFSDEEL;VLYWGHHVPMYLILL;YLILLAVTVPLVLLIVL 7 22.5 0.9923 -0.14052 13.6856 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SGG6 A0A8P0SGG6_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP19 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843]; metal ion binding [GO:0046872] DLNRIQNKPYTETVDS;HVKPENLRLAENR;LVEFPVRNLDLS;QLCQKTHWPDH;QVPSIPISKCAACQRKQQS 5 5.4 0.98738 -0.37085 0 0 0 0 10.6571 0 0 7.50748 7.47654 0 7.48349 0 0 0 10.6253 A0A8P0SGI0 A0A8P0SGI0_CANLF Polymeric immunoglobulin receptor PIGR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDTIGEKSNVDLQ;EVNIVEGGS;IDHLTQNDSGRYK;SDGYVSKDYEGR;TALVGETLKLPCHFPCKYYSY;VGETLKLPCHFPCKYYSYEKYWC;VGGSVAVF 7 10.8 0.73214 0.25038 9.13101 0 0 0 0 0 0 0 9.82856 0 0 9.73491 0 9.50956 0 A0A8P0SGI8 A0A8P0SGI8_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) OTUD7B Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; zinc ion binding [GO:0008270] EPGGELLVHRF;EPVYESLEEFHV;IEQSMLVALEQ;NCSFYGHPETNNFCSCCYR;NGGGGGSS;PETNNFCSCC;SMLVALEQAGRLNWWVSVDPTCQRL;SNGGGGGSSEHPLEMPICA 8 10.6 1.0032 -2.3337 0 12.5175 11.9215 0 15.4365 0 16.7523 0 0 8.21461 17.0463 7.98931 0 11.3911 11.3139 A0A8P0SGQ1 A0A8P0SGQ1_CANLF Cas scaffold protein family member 4 CASS4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] cytoplasm [GO:0005737]; focal adhesion [GO:0005925] ALQQQVAGS;AWPSGQAP;LPSQVYDVP;SLDPDLARETV;SPKRAALGSMTSP 5 6.4 1.0031 -2.3339 0 0 9.34899 0 10.2246 0 11.8201 0 0 8.32607 0 0 0 9.58088 0 A0A8P0SGQ4 A0A8P0SGQ4_CANLF Mast cell immunoglobulin like receptor 1 MILR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLLPGLLLVVIIIIPIL;LLPGLLLVVIIIIPILG;LQLLLPGLLLVVIIIIPILGF;TAMEVGIYANICAN;YVREPAEFNVT 5 13.5 0.99218 -0.28974 7.98465 0 0 0 6.51175 0 0 0 0 3.82619 0 5.89947 11.168 0 0 A0A8P0SGS8 A0A8P0SGS8_CANLF Kelch like family member 24 KLHL24 Canis lupus familiaris (Dog) (Canis familiaris) LHEARRYHILGNE;LSACSSYF;RTRPRRSTGYS;VCLYVMVKYISWVEDG;VGGYDGQNRLSSVECYDSFS 5 11.9 1.0027 -1.7637 0 0 8.91325 7.2791 0 0 10.679 0 0 9.1641 0 0 9.53535 0 0 A0A8P0SGU3 A0A8P0SGU3_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" AGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] FVNSQEWTL;QSCESSKNKSRLTSQSE;RPDGMQQRSYSV;RWWKSRDQAEQ;SLQSCESSKNKSRLTSQ;YHYYSRMANYRNTSEIPLVLVGTQ 6 8.5 0.98792 0.035491 0 0 9.2699 0 0 0 0 0 0 0 0 0 0 9.73517 0 A0A8P0SGU4 A0A8P0SGU4_CANLF Perilipin PLIN1 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] lipid droplet [GO:0005811] DTAEYAANT;GDLPEQENVLQRVLQLPV;LQRVLQLPVVS 3 5.7 1.0026 -0.72041 0 0 0 0 0 0 0 0 0 0 7.85935 0 0 7.50827 5.93423 A0A8P0SGU5 A0A8P0SGU5_CANLF Protein-tyrosine sulfotransferase (EC 2.8.2.20) TPST2 Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] protein-tyrosine sulfotransferase activity [GO:0008476] FLGISWSDAVLHHEDL;GVTDEVLDAAMQAFI 2 8.2 0.92923 0.10764 0 0 0 0 0 0 9.54301 0 7.5366 0 0 0 0 0 0 A0A8P0SGV0 A0A8P0SGV0_CANLF SH3 domain binding protein 4 SH3BP4 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; nucleus [GO:0005634] EAPGKRDNPFFRSKRSY 1 1.8 0.98413 0.046227 0 0 0 0 7.48285 0 0 0 0 0 0 0 0 0 0 A0A8P0SGV1 A0A8P0SGV1_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP15 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] KSDYLYKPSLQSKHYWDRS;RKEKPLRKLAAPF;VLISGDVICFQADVIVNTV 3 6.7 0.99154 -0.19428 9.59092 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SGV6 A0A8P0SGV6_CANLF DNA-dependent metalloprotease SPRTN (Protein with SprT-like domain at the N terminus) SPRTN Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; proteolysis [GO:0006508] chromosome [GO:0005694]; nucleus [GO:0005634] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; single-stranded DNA binding [GO:0003697] AENKDKSNRGETQ;ERDRAQAPLSL;KWSSHPTA;PTAATQDSSSASSQNRMVDC;SEPLLKLRPRK 5 12.3 1.0027 -1.3881 0 0 0 4.11545 0 0 0 0 0 10.6551 0 8.17288 0 0 0 A0A8P0SH02 A0A8P0SH02_CANLF Pyruvate carboxylase (EC 6.4.1.1) PC Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; pyruvate metabolic process [GO:0006090] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736] AEAEAQAEELSFPRSVV;DLAQFMVQNGLSRA;IVGDLAQFMVQNGLS;KDMAGLLKPTACTMLVSSL;KVHVTTDMTLEGDDLILEI;LLATRVRTHDLKKI;VHPGYGFLSE 7 8.6 1.0043 -0.82103 10.3174 7.06232 6.41983 0 9.27901 0 0 0 7.75922 0 0 10.67 10.0941 0 0 A0A8P0SH09 A0A8P0SH09_CANLF Solute carrier organic anion transporter family member SLCO1A2 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] IVQFNAFVNMFTFMPK;WGMLKCGESGACRIYDSTNFRYIY 2 6 0.99345 -0.19123 0 0 0 0 0 0 11.823 0 0 0 0 0 0 0 0 A0A8P0SH24 A0A8P0SH24_CANLF Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) RABGGTA Canis lupus familiaris (Dog) (Canis familiaris) prenylation [GO:0097354] Rab geranylgeranyltransferase activity [GO:0004663]; zinc ion binding [GO:0008270] EPNWARELELCARF;FRVIWTAGDAQKECVL 2 5.7 0.91883 0.11292 0 0 0 0 0 0 9.96347 0 0 0 0 0 0 7.638 0 A0A8P0SH60 A0A8P0SH60_CANLF ADAMTS like 4 ADAMTSL4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] ESGEELDEHSCA;ESLSAQGPTTQPVDVYVIFQ;GVWGPWDPWTSCSQ;WYTGPWAECSSE 4 5.4 0.9942 -0.078819 0 0 0 5.97659 0 0 5.38146 0 6.86084 0 0 0 0 9.49043 0 A0A8P0SH75 A0A8P0SH75_CANLF Zinc finger protein 148 ZNF148 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DASGEIHPPKLVLKKINSK;KKINSKRSLKQPLEQ;PPKLVLKKINSKRSLKQP 3 3.5 0.85097 0.1516 0 4.97778 0 5.93772 0 0 0 0 6.03014 0 0 0 0 0 0 A0A8P0SH92 A0A8P0SH92_CANLF Glypican-1 GPC1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] DVPQAEISG;ITDKFWGPSGAESVIGGVHLWLAE;LYYRGANLHLEDT;MLCSEKMAMSSASDDRCW;NDVDFQDASDDSSGARHGPPA;PDYCRNVLKGCLANQ;VGGLSRRLRARGEA;YCRNVLKGCLANQADLDAEWRNL 8 18.9 0.91953 0.11491 0 0 0 0 0 0 0 0 0 0 10.246 10.1899 0 0 9.00635 A0A8P0SHA0 A0A8P0SHA0_CANLF Pellino E3 ubiquitin protein ligase family member 3 PELI3 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209]; regulation of Toll signaling pathway [GO:0008592] ubiquitin protein ligase activity [GO:0061630] PSGAGSAARMVLEGNPEVGS;SQGSCVLS 2 5.1 0.98788 -0.50504 0 0 8.82728 0 0 0 9.14871 0 9.31981 0 0 0 0 0 0 A0A8P0SHA7 A0A8P0SHA7_CANLF KH and NYN domain containing KHNYN Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] FVPQWRFSKDAKVR;RAPLSEDRESVDPGPMGWRESRGER;RGERHVMEKEGGKQGPPRAMDLGW;TDGVIVSNDQFRDLAE 4 11.5 1.0029 -0.79723 0 0 0 0 8.96933 0 0 7.04461 10.8815 0 0 0 11.0819 0 0 A0A8P0SHB6 A0A8P0SHB6_CANLF Coiled-coil domain containing 6 CCDC6 Canis lupus familiaris (Dog) (Canis familiaris) DGAGGNSG;GGGGGGGG;GGGGGGGGK;SLEMDDERYFN;SNTLFKKIQA;TLEQLRREKIDLEN 6 12.8 1.0032 -1.6119 9.07419 10.2776 7.86567 0 0 0 0 0 0 4.00324 0 0 0 0 9.03183 A0A8P0SHB8 A0A8P0SHB8_CANLF von Willebrand factor A domain containing 5B2 VWA5B2 Canis lupus familiaris (Dog) (Canis familiaris) AVALAWLEHRCA;DLSSKPGHLGTATRELLFLLDGS;DTEASEGPEGLGGADLRG;EQTGTDALTDPVT;EQTGTDALTDPVTDPGP;FVPDAVEALLTPR;GALSAEVL;GLSALSRGQAYFPRPGE;GVGSPQEEGLAWEERAAP;PHQPHLMLEAGSL;VLRVALPSVLTPLAS;VPGCPRHPSLGIARDGPGPES 12 14 1.0034 -2.1017 0 8.8328 9.75979 0 0 0 13.9276 9.03362 0 0 0 0 11.9498 0 7.88545 A0A8P0SHC8 A0A8P0SHC8_CANLF Family with sequence similarity 131 member A FAM131A Canis lupus familiaris (Dog) (Canis familiaris) DEDFTGGTDSDMA 1 3.7 0.94182 0.059691 0 0 0 7.88643 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SHD7 A0A8P0SHD7_CANLF Cathepsin F CTSF Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] lysosome [GO:0005764] cysteine-type peptidase activity [GO:0008234] EDDYSYQGH;INDSMELSQN;SWGTDWGEEGYYY 3 7 1.0037 -0.82284 0 0 0 0 4.45365 8.96573 0 0 0 0 0 13.0187 0 0 0 A0A8P0SHE1 A0A8P0SHE1_CANLF Ras and Rab interactor 1 RIN1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085] AGGRQGDGAFK;PGAGPLGAPSLSNFTPGHPE;SGLDQAHTVPLSPSQELQ;VATALMQDRQT 4 7.6 0.99726 -0.098917 0 12.9358 0 9.69639 0 0 0 0 0 0 8.00011 0 0 0 0 A0A8P0SHE8 A0A8P0SHE8_CANLF CD79b molecule CD79B Canis lupus familiaris (Dog) (Canis familiaris) B cell receptor signaling pathway [GO:0050853] B cell receptor complex [GO:0019815] transmembrane signaling receptor activity [GO:0004888] KDDSKAGMDEDHT;LSPVPHNWLVV;LVVLLLLLSGVPAA;SQNDSVATLTIQGIQFSDNGIYF;TLLIILFIIV 5 30.4 0.98681 -0.40893 0 0 8.87664 0 0 0 0 0 5.07626 0 0 3.7194 5.15676 7.91462 0 A0A8P0SHG7 A0A8P0SHG7_CANLF Leucine rich repeat and Ig domain containing 4 LINGO4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LSGACLTS;QTLEETAFPSPDK 2 3.6 1.0025 -1.0221 8.31922 9.20672 0 0 0 0 0 0 9.97613 0 0 0 0 0 0 A0A8P0SHI6 A0A8P0SHI6_CANLF DDB1 and CUL4 associated factor 17 DCAF17 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] LDDDPEQETYS;VGEAPFGIPCN 2 4.7 0.9817 -0.24872 0 0 0 0 5.85736 0 0 0 0 0 0 0 0 0 0 A0A8P0SHJ1 A0A8P0SHJ1_CANLF Tripartite motif containing 52 TRIM52 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] ATSCSCGCTWDLIF;TSCSCGCTWD 2 4.5 0.99196 -0.55069 0 0 0 0 0 0 0 0 0 0 4.43476 0 0 0 8.24213 A0A8P0SHJ7 A0A8P0SHJ7_CANLF Ankyrin repeat and MYND domain containing 1 ANKMY1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] EGEDPFYYDYKRFLLDDDLTLPP;EMDFESDV;FAKESQWDPK;GPASVYHSQRASA;LDDDLTLPPEMYIYSTDNSH;LSAIGNMNSAP;VTDVDARAADQDDV 7 8.6 1.0042 -1.9804 5.7816 12.7507 0 12.4307 0 0 0 9.34512 13.3939 0 8.11993 10.4262 11.5354 12.7808 0 A0A8P0SHR3 A0A8P0SHR3_CANLF Programmed cell death 1 PDCD1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of immune response [GO:0050777] membrane [GO:0016020] LVIGVTSVLVGVLLLLLLTWVLAA;PGADRVCHH 2 8 1.0023 -0.76291 0 0 0 0 0 0 0 0 4.78215 9.911 0 0 0 0 5.93019 A0A8P0SHS3 A0A8P0SHS3_CANLF Frizzled class receptor 9 FZD9 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] transmembrane signaling receptor activity [GO:0004888] AWGLPALK;PGGGGGGG;TEQPCLAATV 3 4.4 0.99027 -0.53406 0 10.3789 0 0 11.6261 0 0 0 0 0 0 0 0 0 0 A0A8P0SHT9 A0A8P0SHT9_CANLF Protein tyrosine phosphatase non-receptor type 23 PTPN23 Canis lupus familiaris (Dog) (Canis familiaris) multivesicular body sorting pathway [GO:0071985] protein tyrosine phosphatase activity [GO:0004725] FAYLREHFPHAYSVDM;HTPLYPGPSQD;LPEAPQPEEEQPV;QSRVPMGSGQEAA;VIGGKYNSAKKDND 5 4.1 1.003 -0.73049 0 0 0 0 4.74975 0 0 9.99095 9.28757 0 0 0 0 0 0 A0A8P0SHV1 A0A8P0SHV1_CANLF Myomesin 3 MYOM3 Canis lupus familiaris (Dog) (Canis familiaris) DLGTYSVVVTDADEDIS;DLTGEALDAI;GEVRLWLEVEK;KVTDDCQVLLTCKATNTK;LAAALALTASSEKSWE;VGEPRPPQAVEVHR;VTGYRISVQEEGSEQWKPVT;WEPVKDAPELQGYYIYSRQAGS 8 8.8 1.003 -0.78537 11.0613 0 0 0 0 0 0 9.97799 11.5699 0 11.2022 0 0 0 0 A0A8P0SHW6 A0A8P0SHW6_CANLF WD repeat domain phosphoinositide-interacting protein 3 (WD repeat-containing protein 45B) WDR45B Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] phagophore assembly site [GO:0000407] lipid binding [GO:0008289] GTHTGHVQL;NERSLQEFLEGGVG;NPHQLHVFETCY;QEVHLDFVL 4 11.8 0.99034 -0.26204 0 0 0 11.1026 11.483 11.2279 0 5.84295 0 0 11.8858 0 0 0 11.5227 A0A8P0SHX8 A0A8P0SHX8_CANLF Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma PPP2R3C Canis lupus familiaris (Dog) (Canis familiaris) regulation of dephosphorylation [GO:0035303] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] TNEFYKTIPRFYYRLPAED 1 4.2 0.94954 0.049964 0 0 0 0 7.85412 0 0 0 0 0 0 0 0 0 0 A0A8P0SHZ0 A0A8P0SHZ0_CANLF Probable G-protein coupled receptor 33 GPR33 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] ISFFVCWMPYHV 1 3.5 0.98377 -0.24302 0 9.47713 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SHZ7 A0A8P0SHZ7_CANLF Tousled like kinase 2 TLK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EKKENYHKHACREYRIHKELDHPRI;PSVTEMMEELHSLD;VLEYCEGNDLDFY 3 6.5 0.99082 -0.13818 0 0 0 0 9.90474 9.62275 0 11.432 0 0 0 0 10.6049 0 0 A0A8P0SI05 A0A8P0SI05_CANLF 4-trimethylaminobutyraldehyde dehydrogenase (EC 1.2.1.19) (EC 1.2.1.3) (EC 1.2.1.46) (EC 1.2.1.47) (Aldehyde dehydrogenase family 9 member A1) (Formaldehyde dehydrogenase) (Gamma-aminobutyraldehyde dehydrogenase) ALDH9A1 Canis lupus familiaris (Dog) (Canis familiaris) "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" GVCVGIGA;NYNVSPVELP;VIATFTCSGEKEVNLAVQDA;VQGGAATGQLLCQ 4 9.8 1.0042 -1.0905 10.4709 0 0 6.08474 0 0 0 0 10.3533 4.22481 0 0 0 0 0 A0A8P0SI09 A0A8P0SI09_CANLF LRRC37A/B like protein 1 C-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FHKIRSRIVQRTPKTKKSKKFRK;NHHMPQEFLYAE;NNKLILAISVTVVVMILIIV;QEKTLPKAKNLRKR 4 9.7 0.99129 -0.27255 0 0 0 0 0 0 0 0 0 0 11.8308 0 0 0 0 A0A8P0SI11 A0A8P0SI11_CANLF Heteroous nuclear ribonucleoprotein A3 HNRNPA3 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GGGDGGYNGFGGGNYGGGPGYSSRG;TDCVVMRDPQTKR 2 10.1 0.98973 -0.19885 0 0 0 0 0 0 14.1074 0 0 0 0 0 0 0 7.60703 A0A8P0SI18 A0A8P0SI18_CANLF ZPR1 zinc finger ZPR1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] IQELVTKNPFTLGDSSN;KPEEEDLRNEVLQ;KSGGAIEPLGT;VGAQEDMNRQVVKT 4 12 0.98325 -0.25249 0 0 0 0 7.81858 7.72124 9.87563 0 0 0 0 8.95736 0 0 0 A0A8P0SI19 A0A8P0SI19_CANLF MAGE family member F1 MAGEF1 Canis lupus familiaris (Dog) (Canis familiaris) PLEEEEEEED;RTVAELVQFLLVKDKKKSPI 2 9.4 0.99652 -0.57251 0 9.99944 0 0 0 0 0 0 0 0 0 0 0 9.98854 0 A0A8P0SI23 A0A8P0SI23_CANLF Vesicle-fusing ATPase (EC 3.6.4.6) NSF Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; SNARE complex disassembly [GO:0035494] cytoplasm [GO:0005737] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872] EESNFPFIKICS;FEACRSVINLM;IGKAKTKENRQSIINPDWNFEKMGI;ISQQVKGKKVWIGIKKLLMLIE;LLKKAPPQGRKLLIIGTT;VVPGSIAF 6 11.8 0.98628 -0.41399 4.05485 0 9.46365 10.2502 0 0 0 0 4.34241 0 0 0 0 8.6537 9.03092 A0A8P0SI24 A0A8P0SI24_CANLF Apolipoprotein L domain containing 1 APOLD1 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576]; membrane [GO:0016020] lipid binding [GO:0008289] ESLEACTGALDELSEQ;GVATAGGA;VLRLRDVARRLERLRLRSL 3 15.5 1.003 -1.0057 0 0 4.77093 0 10.2158 0 7.62286 0 0 0 0 0 0 0 0 A0A8P0SI29 A0A8P0SI29_CANLF C-type lectin domain family 12 member B CLEC12B Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] signaling receptor regulator activity [GO:0030545] PLPTLSFFWLGLSWDPS 1 6.1 0.97963 0.046227 0 0 0 0 4.25776 0 0 0 0 0 0 0 0 0 0 A0A8P0SI32 A0A8P0SI32_CANLF ETS variant transcription factor 5 ETV5 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] QEAWLAEVPDDEQFVPDFQSDNLV 1 4.7 0.99211 -0.29141 8.98692 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SI46 A0A8P0SI46_CANLF Phosphodiesterase (EC 3.1.4.-) PDE11A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" ILATDLTLYFER;KGIIGYVGE;PSWASGSRADGSLQ;RYLKKLKIK;RYLKKLKIKL 5 4.8 1.0031 -1.6259 0 0 0 8.3462 0 0 0 0 9.73786 0 0 0 0 4.54405 0 A0A8P0SI58 A0A8P0SI58_CANLF Serine incorporator 4 SERINC4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FQKPSLCFCC;FSYEGAEL 2 3.5 1.002 -1.364 0 12.5104 0 0 9.27144 0 0 0 0 0 0 0 0 0 0 A0A8P0SI67 A0A8P0SI67_CANLF "Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase)" ECHS1 Canis lupus familiaris (Dog) (Canis familiaris) hydro-lyase activity [GO:0016836] ATEDRKEGMTAF;STPTPPPH;TDGGGAGA 3 4.1 1.0034 -1.5612 0 0 0 7.47889 0 0 3.96357 0 0 0 0 0 0 0 0 A0A8P0SI95 A0A8P0SI95_CANLF Putative malate dehydrogenase 1B MDH1B Canis lupus familiaris (Dog) (Canis familiaris) malate metabolic process [GO:0006108] "malate dehydrogenase activity [GO:0016615]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" AKVYRYESAI;ALSSQCAC;DSTDQEVYTLEGC;LEYAQLYHGV;YHGVTSSM 5 8.1 1.0031 -2.4868 10.4638 8.84188 0 0 0 8.04117 0 8.57092 0 10.4551 0 0 0 0 0 A0A8P0SI99 A0A8P0SI99_CANLF WD repeat-containing protein 76 WDR76 Canis lupus familiaris (Dog) (Canis familiaris) DTHIYDTRHLNPRGSQ;VYVFQPHSQP 2 4.2 0.98769 -0.48323 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.90418 A0A8P0SIA5 A0A8P0SIA5_CANLF Dual oxidase maturation factor 2 DUOXA2 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] INTNTSYKA;PQPRHAPGFSVPLLIVILVFLAL 2 10 0.88171 0.1324 0 0 0 0 0 0 6.89215 0 0 0 0 0 0 0 0 A0A8P0SIB5 A0A8P0SIB5_CANLF 5-hydroxytryptamine receptor 3B HTR3B Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic membrane [GO:0045211] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888] ELVDVEGSPDL;LMLVDLGSFYLPPT;LYRLTKQLLQKHH;PDIIINELVDVEGSPDLPYV 4 11.1 0.87887 0.13937 0 0 0 8.52231 0 0 0 11.7905 0 0 0 0 9.83573 10.5959 0 A0A8P0SIC6 A0A8P0SIC6_CANLF Peptidase S1 domain-containing protein LOC609323 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GPAASGPWSLSR;GVVSWSLSCNRHR;LLLLLLLL;LLLLLLLLH;LSRRLLLLLLLL;NDMLCVSSEWGMDSCQDNSGSSL;RLLLLLLL;RLLLLLLLL;SIYTSTSQFTHWIKRQISDMRFI;SLSRRLLLLLLLLHSGY;TNYGENLCSGDSGG;VIRHWPWEVSLR;VVTAAHCIQGT 13 21.6 0.99264 -0.55188 6.4848 0 0 0 9.51073 0 5.45319 4.40939 0 0 11.7868 0 8.75759 0 9.35061 A0A8P0SIF0 A0A8P0SIF0_CANLF Rhomboid domain containing 2 RHBDD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] FAMLGVNSVRSRMRRALVF;PAPSAVYRLVTYIFVYE;VLFCFVFFPHGSLSQ 3 12.9 0.85341 0.14967 0 6.83693 8.15158 0 0 0 0 0 0 0 0 0 0 7.81378 0 A0A8P0SIF1 A0A8P0SIF1_CANLF Neurobeachin like 2 NBEAL2 Canis lupus familiaris (Dog) (Canis familiaris) ALVLLKLFI;ALVLLKLFIILCR;ATPEWRHF;AVHVLHAS;GAAVKQQAAQQSTAL;GALDLLLA;PRVLALLR;SLPPPPPPWPF;SVGSCNTA;SVRLDVCRQLFHL;VLLALLVQPRSL;VPRVLALLRKL 12 3.9 0.99663 -4.6985 7.93204 7.76129 0 8.12102 8.31111 8.56007 5.17528 0 0 10.1794 0 3.2216 2.69613 9.30829 11.6322 A0A8P0SIF2 A0A8P0SIF2_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) DTX2 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] DVTHSKTI;LDHSGIGPSH;MASDEDCIICME;TASGASAS 4 6.6 1.003 -2.204 0 0 0 0 0 0 0 0 0 0 9.66926 9.61434 0 0 0 A0A8P0SIF3 A0A8P0SIF3_CANLF glutathione transferase (EC 2.5.1.18) LOC486404 Canis lupus familiaris (Dog) (Canis familiaris) KPEFLKVNPLGKVPA;SRLAEWRMRVELA 2 11.6 0.95282 0.053874 0 0 0 0 6.79662 0 0 0 0 0 0 0 0 0 0 A0A8P0SIF6 A0A8P0SIF6_CANLF Hemicentin 1 HMCN1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] ARYSILENGFLH;CLVISAVDYNLTWQRN;DICQHECKNTFGSYHCIC;DQNQNSYRLLSS;DRGHIGYKVYEE;FCADEDECAAGS;FSAGADGS;IIQVPDNVTVLPG;INDMFIMGS;ISLLCESSGIPPPNLIWKKRGSPV;ITWAKETQLISPFSPRHTFLP;LVRLECEARGIP;LYVASPGGEESG;NGKILKLFKVTPEDVGRY;NLAWFSPVRNSYQPQ;NPYITVRSDG;NTPGSFKC;PILLPCEATGTPSPFI;PNYQRDPVSGF;PVSLSSSVR;RILSSGAIEIFATQL;VGFVKAIG;VLRLSSAQVEDT;WEIEKVTLSDED 24 5.6 0.99692 -6.1026 10.0976 10.7487 11.3744 9.76045 9.15165 9.98954 9.75546 0 12.6604 11.5142 9.26421 0 8.19668 6.73064 7.98908 A0A8P0SIG4 A0A8P0SIG4_CANLF Kinesin-like protein KIF18B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle [GO:0005819] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] KGGKASSSCHSPRI;NWPAEPPSSPRCP;VDERVLVFDPEEPDGGFL;VYEARAQAPPQD 4 6.7 1.0026 -0.77179 0 0 0 0 0 0 0 0 0 0 0 0 14.6218 8.42664 0 A0A8P0SIH9 A0A8P0SIH9_CANLF Major facilitator superfamily (MFS) profile domain-containing protein LOC612044 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AATNTSGAWL;LDQLGAPE;SAHEPATE 3 4.7 1.0009 -0.62842 10.1209 0 0 10.4167 10.3873 10.3883 0 0 10.7294 0 10.5395 10.6589 9.58556 9.71079 10.112 A0A8P0SII1 A0A8P0SII1_CANLF Leucine-rich repeat and WD repeat-containing protein 1 (Origin recognition complex-associated protein) LRWD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] "centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]" AAGLRGLVRLLHVR;LWACAFEPAW;SQVENLNRELTSRVTAHWEK;TSSSSAHVEGSDGSQPTLEP 4 10 0.9859 -0.4523 8.57837 8.73332 9.42196 0 0 0 0 0 0 0 10.4708 0 0 0 0 A0A8P0SIK0 A0A8P0SIK0_CANLF Basic leucine zipper ATF-like transcription factor 2 BATF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ADALHQHETLE 1 4.1 0.99228 -0.13908 0 0 0 0 0 0 12.5101 0 0 0 0 0 0 0 0 A0A8P0SIK6 A0A8P0SIK6_CANLF NKG2-A/NKG2-B type II integral membrane protein-like Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AELNLQNDLQRND;YLPSSLEKLVAGILA 2 19.3 0.9894 -0.52041 0 0 0 7.83029 0 0 0 0 12.0031 0 0 0 0 0 0 A0A8P0SIL3 A0A8P0SIL3_CANLF Suppressor of tumorigenicity 7 protein-like ST7L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FPPLTMLNIHENLL;GVFAKAPS;IEGALNLLQCTWEGTFRMIPYP;LSQWPPSGPP;VLAKYDDIS 5 9.7 0.99013 -0.2636 0 0 0 0 0 0 0 7.14853 0 0 0 0 8.4405 0 0 A0A8P0SIM4 A0A8P0SIM4_CANLF ADAM metallopeptidase domain 11 ADAM11 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] CSLSRGGGV;GEECDCGSVQ;GLPEPSDATH;HSETKYVELIVVNDHQ;HSSGAGDHCYY;ICSLSRGGGVNEYD;QGLHGVFSDGNF;SETKYVELIV;SSSGAAYV 9 10.6 0.99864 -2.9957 5.67404 0 9.46534 0 10.2986 10.009 0 0 2.04792 0 10.6037 9.01945 0 0 12.2066 A0A8P0SIM7 A0A8P0SIM7_CANLF Receptor transporter protein 4 RTP4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EGWKQYQQKGF;HDTINCEACTLGY 2 5.6 0.98986 -0.21393 0 0 0 9.87317 8.66984 0 0 0 0 0 10.8625 0 0 0 0 A0A8P0SIN2 A0A8P0SIN2_CANLF Upstream binding transcription factor UBTF Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AAYKEYISNESEEDDEEDEEDEDED;AYKEYISNESEEDDEEDEEDEDEDE;DEDEDDDEDDDEDED;DEDEDDDEDDDEDEDNES;DEDEDDDEDDDEDEDNESE;DEDEDEEEEDDENGDSSEDG;DEDEDNESEGSSSSS;DEDEEEEDDEN;DEEDEDEDEEEEDDEN;DEEDEDEDEEEEDDENGDS;DEIMRDYIQKHPEL;DENEEDDEDEDDDED;DESEDGDENEEDDEDEDDDEDDDE;DQKKKDYEVELL;EDDDEDEDNESE;EDDDEDEDNESEG;EDDEDEDDDEDDDE;EDEDEEEE;EDEDEEEEDDENGDSSEDGGDSSE;EDEEDEDEDEEEEDDENGDSSE;ENEEDDEDEDDDEDDDEDEDNESE;ESEDGDENEEDDEDEDD;ESSSEDESEDGDENEEDDEDEDD;EYISNESEEDDEEDEEDEDEDEEEE;GDENEEDDEDEDDDED;GDSSEDGGDSSESSSEDESEDGD;GDSSEDGGDSSESSSEDESEDGDEN;NEEDDEDEDDDEDDD;NEEDDEDEDDDEDDDEDEDN;SEDGDENEEDDED;SEDGDENEEDDEDEDDD;SEDGDENEEDDEDEDDDEDD 32 15.9 0.86095 0.17616 0 0 0 0 0 0 7.51128 6.68328 0 0 0 0 5.34972 9.69397 0 A0A8P0SIN3 A0A8P0SIN3_CANLF Talin rod domain containing 1 TLNRD1 Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779] VGFATEPQFLG;VLFEGPAASCAGAAESF 2 7.7 0.98991 -0.21167 0 0 0 0 0 0 9.87984 6.91133 0 0 0 0 0 0 0 A0A8P0SIN6 A0A8P0SIN6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ESYFYLGAPSCLPSQ;TVLGKWFSPCFSTC 2 20.7 0.9843 -0.2381 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.47492 A0A8P0SIP1 A0A8P0SIP1_CANLF Eukaryotic translation initiation factor 4E binding protein 2 EIF4EBP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of translational initiation [GO:0045947] eukaryotic initiation factor 4E binding [GO:0008190] AIGKKKKKKKKGL;CCCCWGCW;CCWGCWRRPEDR;HKLILKKKKKSL;IGKKKKKKKKGLPFL;KKKKKKKGL;KKKKKKKK;KKKKKKKKGLPFLA;KKKKKKKKGLPFLAQ;PLAGAAGA;PWPRPSSAPPPPQ 11 18.2 1.001 -2.7234 8.48224 8.60441 10.1364 5.29138 0 0 9.39915 9.31612 0 4.09761 6.14806 0 11.3659 6.75956 11.3525 A0A8P0SIP3 A0A8P0SIP3_CANLF MAU2 chromatid cohesion factor homolog (Cohesin loading complex subunit SCC4 homolog) MAU2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic sister chromatid cohesion [GO:0007064] nucleoplasm [GO:0005654] NHRSNNMVVPAMQ;VGAEYARVVGSEY 2 4.2 0.98418 -0.24205 0 0 10.7786 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SIP4 A0A8P0SIP4_CANLF Adhesion G protein-coupled receptor A1 ADGRA1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AGSVLYGCAL;HYSTLATMLWIGV;IALVTCVYFL;VYFLGTYVQ 4 6.6 1.0024 -1.1653 0 0 0 0 0 0 0 0 0 14.5494 0 0 0 0 0 A0A8P0SIQ9 A0A8P0SIQ9_CANLF RUN domain-containing protein 3A RUNDC3A Canis lupus familiaris (Dog) (Canis familiaris) GTLNGAEG;VPGELQIQRVPGE 2 5.3 0.98684 -0.37976 0 0 0 0 0 0 0 0 0 9.96062 0 10.0678 0 0 0 A0A8P0SIR9 A0A8P0SIR9_CANLF Cadherin related 23 CDH23 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DVGLNAELSYF;DYEEVHWLNFTVRASD;EPAGTSVITMMA;EQIPNGLIYLTVMAKDAGNPPLNS;FLQSSYEASVPEDIPEG;GPIKGSLLKV;HILASDADSGCNALLTFN;IMDMPNTNKYSF;LAYSLEGPGVEAFHVD;LAYSLEGPGVEAFHVDMDSGLVT;LDINDNDPVL;QKDAYVGALRENEPSVT;RSREYGQESIIYSLEGSSQF;SNRRENSVQVV;TAGNRERAFSI;TLTVVADD;VLDINDNDPVL;YRILSGAEGKFEID 18 7 0.99995 -2.842 0 0 7.31497 0 11.4982 0 9.04445 12.4187 0 8.32039 7.06587 8.90965 9.2521 0 11.9912 A0A8P0SIT2 A0A8P0SIT2_CANLF Salvador family WW domain containing protein 1 SAV1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; hippo signaling [GO:0035329]; regulation of cell population proliferation [GO:0042127] molecular adaptor activity [GO:0060090] HEDYRYYEYN 1 2.7 0.99942 -0.61146 0 0 0 0 0 0 0 0 7.9305 0 0 0 0 0 0 A0A8P0SIT6 A0A8P0SIT6_CANLF BCL6 corepressor BCOR Canis lupus familiaris (Dog) (Canis familiaris) CTDEEEDCQAASL;FHKHYARISTSPSVT;LYLPPPHYVSPHIPSSLASPMRLS;PSQPAADT;SAVSGKAPNGFS;SDEDSNGSWEFYGSSVCEPD;SPMRLSTPSAS;TVEASAVSGKAP;VGSAPPSVDVTPTY;YSGRTIMKMT 10 7.5 1.0043 -2.0046 0 0 8.36672 8.01976 11.0842 0 10.3604 10.4447 0 8.03034 7.91289 9.68536 7.2363 9.96483 0 A0A8P0SIT7 A0A8P0SIT7_CANLF Cohesin subunit SA (SCC3 homolog) (Stromal antigen) STAG3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome segregation [GO:0007059]; sister chromatid cohesion [GO:0007062] "chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; nucleus [GO:0005634]" EHLIPLLP;EHQEEIEGMMNAL;FNEDSGDYPLTAPG;HLRRNVKKRAAKRPL;LLDSTELNLEDF;LVDSLWDCAGSQLKDWESLTSLL;TQGQPLSGNQR 7 7.8 1.0032 -1.7365 10.3243 0 9.75931 9.6162 0 0 9.63854 0 7.22381 6.98607 0 0 0 0 0 A0A8P0SIT9 A0A8P0SIT9_CANLF Zinc finger B-box domain containing ZBBX Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] CKTASEAKCSQNESDEDS;CLECGEDYCSGCFAK;DDTYEEEYEEPGDI;LVCLECGEDYCSGC;PEPSLKIVELDDTY;SAGKVKLKLLKEQLQEPVK;SEAKCSQNESDEDSGVE;VIKLSAGKVKLKLLK 8 11.1 0.97699 0.046227 0 0 0 0 7.46442 0 4.47936 0 0 0 0 4.2888 4.84413 0 0 A0A8P0SIU4 A0A8P0SIU4_CANLF Solute carrier family 29 member 3 SLC29A3 Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] nucleoside transmembrane transporter activity [GO:0005337] APGSSESSTPPLWPILK;IVPRELAEATGVVMSFYV;LVSEDPWEGP 3 8.8 0.98959 -0.51692 0 0 0 0 8.36829 0 0 0 0 0 9.39348 0 0 0 6.0243 A0A8P0SIX4 A0A8P0SIX4_CANLF Cilia- and flagella-associated protein HOATZ HOATZ Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] LVFAGSSEQDSNLAKQFWIAASLY 1 14.4 0.9925 -0.17816 0 0 0 9.97943 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SIX5 A0A8P0SIX5_CANLF EF-hand domain-containing family member C2 EFHC2 Canis lupus familiaris (Dog) (Canis familiaris) axonemal microtubule [GO:0005879] DSDLFIGATINVW;EEESKSREIKQ;GVKLNPPG;IEVKEVMPHNSG;NWRINPMPELEATLYT;REKKKVLPSKDIRRLCKSFRL;YAPDEIEFDLE 7 11.8 1.0025 -1.1985 6.99718 0 0 7.90947 9.97943 0 0 0 8.3743 6.31297 0 10.1447 0 0 0 A0A8P0SIX9 A0A8P0SIX9_CANLF Alanyl-transfer RNA synthetases family profile domain-containing protein LOC480510 Canis lupus familiaris (Dog) (Canis familiaris) alanyl-tRNA aminoacylation [GO:0006419] cytoplasm [GO:0005737] alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] FSGPFQTLRLL;VEQVRGRGLPDDHA 2 5 0.98088 0.035491 0 0 0 0 0 7.33226 0 0 0 0 0 0 0 0 0 A0A8P0SJ23 A0A8P0SJ23_CANLF Activating signal cointegrator 1 complex subunit 1 ASCC1 Canis lupus familiaris (Dog) (Canis familiaris) DNA alkylation repair [GO:0006307] RNA binding [GO:0003723] EEEDEDFYQ;LHATVMNTLFR 2 7.9 0.99118 -0.27596 0 0 0 0 0 0 0 7.36361 0 0 0 0 0 0 0 A0A8P0SJ26 A0A8P0SJ26_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHB2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] IVHPPSGWEEVSG;YTSGHMTPGMK 2 2.4 0.99446 -0.025 0 0 0 0 0 0 0 0 0 8.9479 0 0 8.04641 0 0 A0A8P0SJ27 A0A8P0SJ27_CANLF Membrane cofactor protein LOC102156626 Canis lupus familiaris (Dog) (Canis familiaris) single fertilization [GO:0007338] cell surface [GO:0009986]; inner acrosomal membrane [GO:0002079] ERELTCIEKNKWSSR;FEYNELITFSCNRLK 2 8.5 0.99484 -0.18921 0 0 10.5699 0 0 0 6.99481 0 0 0 0 0 0 10.2471 8.89327 A0A8P0SJ39 A0A8P0SJ39_CANLF MAGUK p55 scaffold protein 3 MPP3 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] GASGGRGS 1 1.1 0.98996 -0.2654 0 0 0 0 0 0 0 0 0 0 9.72477 0 0 0 0 A0A8P0SJ50 A0A8P0SJ50_CANLF Estrogen related receptor alpha ESRRA Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear steroid receptor activity [GO:0003707]; sequence-specific DNA binding [GO:0043565]; steroid binding [GO:0005496]; zinc ion binding [GO:0008270] VGGALAKV 1 1.3 1.0042 -1.1044 0 5.77936 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SJ67 A0A8P0SJ67_CANLF Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) Canis lupus familiaris (Dog) (Canis familiaris) platelet activation [GO:0030168]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229] plasma membrane [GO:0005886] alpha2-adrenergic receptor activity [GO:0004938] ADILVATLVMPFSLANELMAYWY;GVYLALDVLFCTSSIVHLCAI;LVSLYRQP;QAVEYNLKRTPRRVK 4 14.9 1.0032 -1.916 0 0 0 0 0 9.27074 10.0352 8.36308 0 0 0 0 0 0 0 A0A8P0SJ96 A0A8P0SJ96_CANLF V-type proton ATPase subunit a ATP6V0A1 Canis lupus familiaris (Dog) (Canis familiaris) "clathrin-coated vesicle membrane [GO:0030665]; melanosome [GO:0042470]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]" "proton-transporting ATPase activity, rotational mechanism [GO:0046961]" DEVFDFGDTM;EGQPVEAP;IDVTQKCLIAEVWCPVTD;MVHQAIHTIEY;PTYNKTNKFTYGFQ;YFGFIPEIIFM;YNWTEETLRGNPVLQ 7 10.3 1.0019 -1.2073 14.822 5.77642 10.114 0 0 0 10.6889 0 0 0 10.0189 0 0 0 7.27473 A0A8P0SJA3 A0A8P0SJA3_CANLF Leucine rich repeat containing 25 LRRC25 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GQPDAGHQWAENGV;LAMLCQLDLKA;LEKLQVLDVTNNS;VGQPDAGHQWAENGV;VLKSWHQVRQN 5 16.8 0.99729 -0.10811 10.3302 10.2014 12.162 8.908 6.28817 0 10.6325 10.3145 10.2212 9.98954 11.142 10.4207 9.47826 10.1824 10.4794 A0A8P0SJB9 A0A8P0SJB9_CANLF Insulin-like growth factor-binding protein 2 IGFBP2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] insulin-like growth factor binding [GO:0005520] EPGCGCCSVCARLE;GCGCCSVCA;LDQVLERISTMHL;PERLAACGPPPAAPPAAASGVSGVS 4 15.6 0.98596 -0.43312 0 9.10282 8.46899 8.43271 8.38608 8.46663 0 0 0 0 10.5561 0 0 6.92908 0 A0A8P0SJD2 A0A8P0SJD2_CANLF Nuclear pore associated protein 1 LOC102151355 Canis lupus familiaris (Dog) (Canis familiaris) AASASLPASMAPG;SPQGTEDKVPEHPG;VGGAGAPT 3 3.1 0.98177 -0.24961 0 0 0 0 9.38424 0 0 0 0 0 0 0 0 0 0 A0A8P0SJD5 A0A8P0SJD5_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP11 CDK16 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] ADLFEDQVNWRLKKG;ESGRERPLRAGESWFLVEQHWYKR;ETLEKENPWFCPTCKQ;PEMKKRYYDEVEAEGY;RLVVPKKGKI 5 8.9 0.98997 -0.51626 0 0 0 7.80903 0 0 0 13.7849 0 0 0 0 0 0 0 A0A8P0SJD7 A0A8P0SJD7_CANLF Ess-2 splicing factor homolog ESS2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] HTWLYQAEEEFE;QVVHKNTRFLR 2 4.8 0.99184 -0.54385 0 0 0 8.9284 0 0 12.7366 0 0 0 0 0 0 0 0 A0A8P0SJE3 A0A8P0SJE3_CANLF Interleukin 12 receptor subunit beta 1 IL12RB1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RLIPLLWLIPLLLLPL;SNSGGEVTYSV;VGSATSLQFSDQDGV 3 5.7 0.96312 0.049233 0 0 0 0 0 0 6.00993 0 0 0 0 0 0 0 0 A0A8P0SJG0 A0A8P0SJG0_CANLF Negative elongation factor complex member A NELFA Canis lupus familiaris (Dog) (Canis familiaris) LSSAVKLKLLLG;MFKTANKVTRPE;SGPSPAASAPSTPTSPLTPTTPPAV;VIQIKLSEHT 4 11.1 0.98719 -0.49838 0 0 0 0 0 0 9.67437 0 7.98539 0 3.92153 4.03457 0 0 0 A0A8P0SJG2 A0A8P0SJG2_CANLF FERM domain containing kindlin 3 FERMT3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] EAQLRFIQAWQSLPDFGISYI;EEIKRKQDWSDHA;LTQLYEQARWDLLLEETDCTEEEMM;RAPEKKEKKKKEKE;SAEGLNPYGLV;SDHAIWWEQKRQWLLQTHWTLDKY;VILRLPNRRALRL 7 17.5 1.0018 -0.66174 9.30959 0 8.14736 0 4.41115 7.45968 0 6.54919 0 7.91755 0 8.62205 11.292 0 10.8044 A0A8P0SJI8 A0A8P0SJI8_CANLF G protein-coupled receptor 137C GPR137C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMLVHGDV;AMLVHGDVPE;GGGGGGGA;GGGGGGGG;PGGGGGGG;PHLNGPVTDTA;STPGGGGGGG 7 7.8 1.0027 -1.1449 0 11.5879 0 0 0 0 0 0 0 0 0 11.5651 0 0 0 A0A8P0SJI9 A0A8P0SJI9_CANLF Family with sequence similarity 53 member A FAM53A Canis lupus familiaris (Dog) (Canis familiaris) AEGEGGSSGDPSDWD;PSDWDSAGEEGIFPPS;PSSASGGCMDSCEGSSGLPRR 3 12.7 0.96084 0.049233 0 0 0 0 0 0 8.54036 0 0 0 0 0 0 0 0 A0A8P0SJJ2 A0A8P0SJJ2_CANLF Cyclin Pas1/PHO80 domain containing 1 CNPPD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] EWTWPLLTPRAL;LFCSTHWGL;VGLGLSPRLAQLLTAIP 3 6.2 1.0042 -1.0814 8.66089 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SJK1 A0A8P0SJK1_CANLF Matrix metallopeptidase 8 MMP8 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] KGSQYWALSGYDIKQGYPKDISDYS;RKLPLLLL 2 6.9 0.98683 -0.23038 8.72363 6.45763 0 0 0 0 10.2439 7.30925 9.9137 5.3535 0 8.94014 8.73948 7.40965 0 A0A8P0SJL7 A0A8P0SJL7_CANLF MYB binding protein 1a MYBBP1A Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleolus [GO:0005730] DNA binding [GO:0003677] DDKHSASEEDSDEEDSD;DPEWEQLVGQILA;EDSDEEDSDEEDRDGD;FLDFFWDIAKPEQETRLAATE;FSHICSHLTPRALQLILDVLNPEQS;HLQEQPQKALVDIL;HSASEEDSDEEDSDEED;LHVPERAVLRLRKWVILRLV;SEEDSDEEDSDEEDRDGDVDQ;SPLTIPMFLSL;STSGQKKAQDASLHVPE;VERLVEQA 12 11.4 0.96616 0.048523 0 9.70247 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SJM2 A0A8P0SJM2_CANLF "N-alpha-acetyltransferase 30, NatC catalytic subunit" NAA30 Canis lupus familiaris (Dog) (Canis familiaris) peptide alpha-N-acetyltransferase activity [GO:0004596] AGAALACCSEDEEDDE;CSEDEEDDEE;GGGGGGGG;GGGGGGSG;GVHSGESPPHCLP;LACCSEDEEDDEE;SEDEEDDEEHEGGGGGGGG;SLRSPSGREVE 8 14.4 1.0031 -1.5635 0 0 0 0 0 0 10.3137 0 0 0 6.59723 0 5.48733 13.6775 8.82404 A0A8P0SJN6 A0A8P0SJN6_CANLF ZW10 interacting kinetochore protein ZWINT Canis lupus familiaris (Dog) (Canis familiaris) kinetochore [GO:0000776] ALGDILEPVGRQEEVELPA;VGRQEEVE 2 6.6 0.9871 -0.35579 0 0 0 0 0 0 0 0 9.17697 0 0 0 0 0 0 A0A8P0SJP3 A0A8P0SJP3_CANLF Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein folding [GO:0006457] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] ANAGPNTNRSQFFICT 1 10.8 0.98448 -0.23909 0 0 0 0 0 0 0 0 10.1918 0 0 0 0 0 0 A0A8P0SJQ4 A0A8P0SJQ4_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP8 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] EEMEKRESEQVKKEDKETSKR;LYMKYVTVY;NNRFYCSHCR;SNLLGHKG;VLAGGYENWL 5 5.3 1.003 -1.5306 0 0 0 0 0 6.58577 0 0 10.6433 0 0 0 0 0 11.5353 A0A8P0SJR6 A0A8P0SJR6_CANLF Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 ANKZF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] endonuclease activity [GO:0004519]; metal ion binding [GO:0046872] APLQRGDPRLWDIPLAT;GTLDLREFEVLPKRRRRKRNKKER;VLFQNAQGQFLYAYRCVL;VLPKRRRRKRNK 4 8.2 0.99658 -0.10079 8.68696 8.19613 0 0 0 5.38398 0 0 0 0 0 0 0 0 0 A0A8P0SJS3 A0A8P0SJS3_CANLF Radial spoke head 10 homolog B LOC608989 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] FPNLEVEFLSHLD;LELVFLEFFEAL 2 2.9 0.99067 -0.53735 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.67177 A0A8P0SJS8 A0A8P0SJS8_CANLF Proprotein convertase subtilisin/kexin type 1 inhibitor PCSK1N Canis lupus familiaris (Dog) (Canis familiaris) endopeptidase inhibitor activity [GO:0004866] DDPEAPAA;GVGLLVLLLLGLLR;VGLLVLLLLGLLRPP 3 7 0.9922 -0.14418 0 0 0 0 0 0 0 0 8.23515 0 9.55125 0 3.71447 0 0 A0A8P0SJT7 A0A8P0SJT7_CANLF "Inhibitor of CDK, cyclin A1 interacting protein 1" INCA1 Canis lupus familiaris (Dog) (Canis familiaris) LEDLRRRQRLINE;QRYRDIFWENLSQRPSPTWTEEQY 2 15.8 0.9402 0.10117 0 0 0 0 0 0 0 0 10.7025 0 7.92861 0 0 0 0 A0A8P0SJU2 A0A8P0SJU2_CANLF Chromosome 20 C19orf44 homolog C20H19orf44 Canis lupus familiaris (Dog) (Canis familiaris) ALHDMLKQQLSLTQ;DLAPAVSEN;LLKDKAVVEGWRSLSSG;SESRAHPEESPDRMLDT 4 8.9 0.99668 -0.57637 10.2442 0 0 7.10926 9.05162 0 0 6.38633 0 0 0 0 10.4322 9.72301 0 A0A8P0SJV6 A0A8P0SJV6_CANLF EvC ciliary complex subunit 1 EVC Canis lupus familiaris (Dog) (Canis familiaris) smoothened signaling pathway [GO:0007224] ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EDCSSSSS;QVWMEEHALSSVLQTH;SFLAEAQA;VDEYEPSFNSNITAFALKAKV 4 5.4 1.0033 -2.4118 8.36619 0 0 0 0 0 0 0 4.36562 0 0 0 10.8486 0 0 A0A8P0SJV7 A0A8P0SJV7_CANLF ER lumen protein-retaining receptor KDELR2 Canis lupus familiaris (Dog) (Canis familiaris) protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031] COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] ER retention sequence binding [GO:0046923] DTFRVEFLVVPVGGLSFL;RCLIRKIRNLTLLL;YLIYMKFKATYD 3 13.9 0.93893 0.060769 0 0 0 0 0 0 0 0 0 0 0 0 3.95568 0 0 A0A8P0SJX5 A0A8P0SJX5_CANLF Acid sensing ion channel subunit family member 4 ASIC4 Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] membrane [GO:0016020] sodium channel activity [GO:0005272] GVAPSQDPPSDLHR;HQLADMLKSCNFSGHH;IYEQGVLGPTEAGVAPSQDPP;LVLDVFFEALTSEAM 4 11.1 0.95384 0.049514 0 0 0 0 0 8.07762 0 0 0 0 0 0 0 0 0 A0A8P0SJY6 A0A8P0SJY6_CANLF NACHT and WD repeat domain containing 1 NWD1 Canis lupus familiaris (Dog) (Canis familiaris) EIQDLNKHILE;EIRHHLGLSTEATW;GIEGLLEDFD;LVLSASKDHTLRLWNLLSG;QEVLGSMNWISCRG;QEVLGSMNWISCRGV;QGKMVTGFSKGSISLVSPGGD;SPGDPCPVIDGPTYTF;TELLARLHFFA;TPFLDRTGLTAVS 10 8.3 1.0019 -1.2641 0 0 0 8.88521 8.73992 0 7.0955 0 11.1426 7.82737 0 8.72731 9.321 8.11686 10.3518 A0A8P0SJZ6 A0A8P0SJZ6_CANLF Saccharopine dehydrogenase-like oxidoreductase SCCPDH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TQRYLHENLEQSP 1 3 0.94606 0.079344 0 0 0 0 9.13011 0 0 0 0 0 0 0 0 0 0 A0A8P0SJZ7 A0A8P0SJZ7_CANLF RNA binding motif protein 3 RBM3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723] GGAFGAHG 1 5 1.0033 -1.1044 0 0 0 0 0 0 0 0 11.2239 0 0 0 0 0 0 A0A8P0SK07 A0A8P0SK07_CANLF "Complement component 1 Q subcomponent-binding protein, mitochondrial" C1QBP Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] mitochondrial matrix [GO:0005759] AFVEFLNDE;GSAPPPPC;HAGGGEGHTLGAVCVRVP;LPSGLGVPRGDPAPAA 4 11.6 1.0022 -1.8793 0 0 0 0 0 0 0 15.9882 0 0 0 10.1729 7.47452 0 0 A0A8P0SK35 A0A8P0SK35_CANLF "Keratin, type I cytoskeletal 25 (Cytokeratin-25) (Keratin-25) (Type I inner root sheath-specific keratin-K25irs1)" KRT25 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intermediate filament [GO:0005882] structural molecule activity [GO:0005198] FGGSSSGG;GAGNTCSMS;TTSARNELTEMKRNLQ;VLEEVDQRSKILTTRLH;VLQIDNARLTADDF 5 14.2 1.0026 -1.1796 0 11.9304 0 0 0 8.81436 12.4617 0 0 10.6595 10.4949 0 0 0 0 A0A8P0SK61 A0A8P0SK61_CANLF Actin beta ACTB Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDDIAALVVDNG;EEHPVLLTEAPLNPK;FNSHSKYREM;GDDAPRAVFPSIVG;LTEAPLNPK;RVAPEEHPV;RVAPEEHPVL;TEAPLNPK;VAPEEHPVL;VAPEEHPVLLTEAPLNPK;YASGRTTGIVMDSGDG 11 13.4 0 5.4616 0 11.0456 10.4667 10.7922 10.9761 11.7832 11.4961 12.6402 12.587 10.95 10.9199 10.6733 13.4709 10.8308 0 A0A8P0SK64 A0A8P0SK64_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) BMPR1A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] GVTLAPED;LIDQSQSSGSGSGLPL;LPYYNMVPNDPSYEDM 3 7.8 1.0029 -1.0059 8.57939 0 0 8.76587 0 0 0 0 3.99095 0 0 4.80869 8.34256 8.83615 11.1856 A0A8P0SK67 A0A8P0SK67_CANLF Multimerin 2 MMRN2 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] DLQNDLHQV;EDPAALPL;LAATRRDLQQHQ;SGGSDPPS;VGGSYFPDHGYFLAPERGVYLFAV 5 6.9 1.0035 -2.2379 0 0 0 0 0 0 0 7.20643 0 0 0 0 10.3441 0 10.3103 A0A8P0SK68 A0A8P0SK68_CANLF Immunoglobulin like domain containing receptor 2 ILDR2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] CPDSCCCPQ;CQCCPHSCCCYIRCPCCPDS;CQCCPHSCCCYIRCPCCPDSC;DDDDDDDDSAD;DDDDDDDSAD;DDDDDDDSADD;GVFTGEGCSAGLSPTPTFPD;IRCPCCPDSCCCPQAL;LFFVLVGICWCQCCPHSCCCYI;LGNMDGVVLAWTALFWLT;PQDDDDDDDDDS;QDDDDDDDDD;SCCCYIRCPCCPDSCCCPQALYE;VGICWCQCCPHSCCCYIRCPCCPD 14 9.9 0.98583 -0.24598 0 4.67344 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SKC5 A0A8P0SKC5_CANLF protein-arginine deiminase (EC 3.5.3.15) PADI1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668] DEFLSFVPTSDQ;NVRRRPFSFKWWHMV;YFGQHEGGALGHSVLYLTGV 3 7.3 0.98584 -0.42892 0 0 0 0 0 0 12.309 10.7796 0 0 0 0 0 9.99251 0 A0A8P0SKG3 A0A8P0SKG3_CANLF Pyrroline-5-carboxylate reductase (EC 1.5.1.2) PYCR2 Canis lupus familiaris (Dog) (Canis familiaris) L-proline biosynthetic process [GO:0055129] mitochondrion [GO:0005739] pyrroline-5-carboxylate reductase activity [GO:0004735] IDAVTGLSGSGPAYAF;THSSSGKLLTKNPASGGKKD 2 11.2 0.97496 0.048226 0 0 0 0 0 0 0 0 0 0 0 0 7.52693 0 0 A0A8P0SKH1 A0A8P0SKH1_CANLF Regulatory factor X7 RFX7 Canis lupus familiaris (Dog) (Canis familiaris) DNA-binding transcription factor activity [GO:0003700] ELKEFEPSVSQ;LSKLDSDNDD;MAEEQQQPP;NYTARMNLTQ;PQPIGIVV;SQTNESYFPFDDE;TLEELKNDPLF;VEQLSAVTIEGQKPG;VKATKVCDQRTKCKS 9 7.3 1.0031 -2.4352 0 0 0 7.97625 8.03304 8.27366 0 0 6.5311 0 0 9.09062 0 8.34181 3.56973 A0A8P0SKH6 A0A8P0SKH6_CANLF Replication stress response regulator SDE2 SDE2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; DNA replication [GO:0006260]; mRNA processing [GO:0006397]; ribosome biogenesis [GO:0042254]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; RNA binding [GO:0003723] EDEAAGPG 1 1.8 1.0042 -1.1044 0 0 0 0 6.36485 0 0 0 0 0 0 0 0 7.31949 0 A0A8P0SKH7 A0A8P0SKH7_CANLF WIZ zinc finger WIZ Canis lupus familiaris (Dog) (Canis familiaris) GVTEWCVNGSPIETLSEWIKHR;ILKRRTQSRPG;IVRTVKPHIEL;MDLGSPPL;QEPPADLA;SEDEGPLNLTSGPEPAR;VGAYRSYIQ 7 4.9 0.98879 -0.22617 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0995 A0A8P0SKK1 A0A8P0SKK1_CANLF Fc receptor like 2 LOC490399 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DQPIFIQVAL;PPILYRFYYDDVFL;SGALNVTVRAPASRPVLT 3 8.4 0.98324 -0.2559 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.18839 A0A8P0SKL9 A0A8P0SKL9_CANLF Paralemmin 3 PALM3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] membrane [GO:0016020] AEGPEQQEDPQSP;AEKRRLQEEIRAARRELEEEKLRV;VESQGPSGDPTPLL 3 6.8 0.98981 -0.20473 0 0 0 4.30115 0 0 0 9.11314 0 0 0 0 0 0 0 A0A8P0SKM0 A0A8P0SKM0_CANLF Family with sequence similarity 114 member A1 FAM114A1 Canis lupus familiaris (Dog) (Canis familiaris) AGSGGPRN;DMMEESEENT;DTGQHEQP;EDTEAHCDSAMISDEPTT;ETKTKTVEEVYMLSIE;MISDEPTT 6 10.7 1.0033 -1.5535 0 0 0 0 7.2902 0 9.68213 11.883 0 9.66809 0 0 0 0 6.64352 A0A8P0SKN9 A0A8P0SKN9_CANLF Death domain containing 1 DTHD1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EMCNLCGMHDECTPL;GDNPWEGSGGATW;GSGRLGQILKQIWRQNLMLKQALL;INSMSSLIVSDN;IVVYKIPKEKVVHNLDQSLL;YLKTQQDTSYPIVSTSPV 6 12.1 0.98781 -0.3722 0 0 6.3079 0 5.18503 5.98119 0 12.7008 0 0 0 0 0 0 0 A0A8P0SKR3 A0A8P0SKR3_CANLF Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) MED1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] mediator complex [GO:0016592] transcription coregulator activity [GO:0003712] PPTSTGGS;SEKLSKMS;TIEGTSAMYKLPIAPLIMGSHP;VSSSGSKS;VTSLPAMTD;VVQRCMSIPVT 6 4.2 0.98943 -0.53184 9.16486 0 0 0 0 0 9.35081 0 0 0 0 10.7589 0 0 0 A0A8P0SKT7 A0A8P0SKT7_CANLF Biorientation of chromosomes in cell division 1 BOD1 Canis lupus familiaris (Dog) (Canis familiaris) LSPPPSASPFSTSPA 1 5.2 0.95369 0.053883 0 0 0 0 0 0 0 0 0 0 4.68622 0 0 0 0 A0A8P0SKT9 A0A8P0SKT9_CANLF Neuroligin 2 NLGN2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; synapse assembly [GO:0007416] plasma membrane [GO:0005886] carboxylic ester hydrolase activity [GO:0052689]; neurexin family protein binding [GO:0042043] ELPPEEEL;GAQRGGGG;RGGGGPGG 3 2.3 0.98617 -0.45418 0 0 11.0735 0 0 0 0 0 0 0 0 0 0 0 10.2873 A0A8P0SKU5 A0A8P0SKU5_CANLF Arrestin-C (Cone arrestin) (Retinal cone arrestin-3) ARR3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165]; visual perception [GO:0007601] VIKKIKIS;VSINNCTNKV 2 4.4 1.0029 -1.7158 8.96261 0 4.10098 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SL08 A0A8P0SL08_CANLF Dynein axonemal heavy chain 2 DNAH2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874]; motile cilium [GO:0031514] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] AASLTRFYFEGFEINLVWSCGIFI;AMLPGEWENTCNEMQRMLIVRSLRQ;CRAGEPNFNIVREF;DLRSGTMPPDH;EEIEFWHNR;EIWEINKDSFIRRYQR;EKIAIEEVKCQTLAD;ELATDVKQKIP;IAIEEVKCQTLADN;IFGTMINQKLQDFEEE;IHFDKDNISDK;IVQDLFPNVE;KTEVEPLQRMFEKFINKMLAFKKD;LASWTRDLAMRVEQ;LMDMSSFD;NPALRERHWDQIRDEIQREFDQES;NSRHSTMIVGCT;QPDIIGRVSLAAKSLCMWVRAMEL;VDTLWIESMNSVMDDN;VLEMLDSLNGEWV;VLYIPAEAMNMAPEVV;YKSMGRMYSGLAQT 22 7.4 1.0033 -1.3348 12.9776 11.2763 10.1144 0 0 9.7531 10.2126 9.23671 0 11.8734 0 8.52595 9.24726 5.99458 8.70134 A0A8P0SL16 A0A8P0SL16_CANLF Nestin NES Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] intermediate filament binding [GO:0019215]; structural molecule activity [GO:0005198] CPCGSPFPSRPSSGLGE;DGLETFLYPEK;DLQEEGKNREDSEADEL;EEDKLDRPN;EVGLPVETQ;LQQLQAERGGLQ;PESLNSLGEGNLE;SLEKENQEPVRSLVED 8 6.2 0.98785 -0.4657 0 0 0 0 0 0 0 0 0 0 0 0 9.60067 0 0 A0A8P0SL36 A0A8P0SL36_CANLF VWFA domain-containing protein ITGAX Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLIAVFFVSLRVVVGAP 1 6 0.97742 0.046227 0 0 0 0 0 0 0 0 0 0 8.13237 0 0 0 0 A0A8P0SL44 A0A8P0SL44_CANLF WW and C2 domain containing 1 WWC1 Canis lupus familiaris (Dog) (Canis familiaris) AEKVRLRLRYEEAKRRIANLKI;DLELDLQATRTWHSQLTQEI;VEQLEMARKRL;VEQLEMARKRLEKDLQAARDTQS 4 6.4 0.86328 0.18003 8.58722 9.4354 0 0 0 0 0 0 0 0 5.47651 0 9.17463 0 11.2834 A0A8P0SL61 A0A8P0SL61_CANLF Speckle type BTB/POZ protein SPOP Canis lupus familiaris (Dog) (Canis familiaris) protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567] nuclear speck [GO:0016607] ENSRFTDCCLCVAGQEFQA;MFEHEMEE;QCPFLGPPRK;RFTDCCLCVAGQEFQAHK;VLETSGWKSM 5 13.2 1.0022 -0.99176 10.6098 8.58056 8.42982 0 0 6.68061 0 0 0 0 0 0 0 8.1374 0 A0A8P0SL73 A0A8P0SL73_CANLF Ubiquitin conjugating enzyme E2 Q1 UBE2Q1 Canis lupus familiaris (Dog) (Canis familiaris) DVSSEDEDEEMPEDTEDLDHYEM;EDGTSHHRARIPS;PGGGPGPG;PQPQGQQQPGPGQQLGGQG;QEDVSSEDEDEEMPEDTE 5 14.9 0.986 -0.41215 0 0 0 0 0 0 0 9.40582 4.94977 0 0 10.5185 0 0 0 A0A8P0SL80 A0A8P0SL80_CANLF Rab-GAP TBC domain-containing protein TBC1D10B Canis lupus familiaris (Dog) (Canis familiaris) ALPSSLTPAQPQDQL;FLVHEVTNLPVTEALIERE;LVHEVTNLPVTEALIE;PVAAVLLMHMPAEQ;SGHGAAPATSASTTQAP;VLYMTEWFMCIF 6 8.5 0.99088 -0.29711 10.4923 4.38598 0 0 0 0 10.9654 0 0 7.87701 10.5202 0 0 0 0 A0A8P0SL81 A0A8P0SL81_CANLF FUS RNA binding protein FUS Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] GGGDRGGFGPGK;GGGGGGGG;GYGNQDQSG;SSSGGGGG 4 6.7 0.98273 -0.25027 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.56272 A0A8P0SL90 A0A8P0SL90_CANLF RUS family member 1 RUSF1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGGGGPG;VFELQQLV 2 2.7 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 8.10087 0 0 0 A0A8P0SL98 A0A8P0SL98_CANLF Zinc finger FYVE-type containing 1 ZFYVE1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CHNCRKEFS;EAVFECDECC;FFYGREVFKTSPAQE;IRKLDCKPDQHLK;LGDASEAY 5 7 1.0033 -2.0552 0 7.50779 0 0 8.6643 2.07053 6.20988 0 0 0 0 0 0 0 0 A0A8P0SLB2 A0A8P0SLB2_CANLF "Beta-1,4-N-acetyl-galactosaminyltransferase 2" B4GALNT2 Canis lupus familiaris (Dog) (Canis familiaris) DVVGGSVLGNVFQFKLLLEKSQNGD;LVGSCPEVVIGHQVRSPMADPEL 2 10.1 0.98215 -0.24868 0 0 0 0 9.03224 0 0 0 0 9.17767 0 0 0 0 0 A0A8P0SLC4 A0A8P0SLC4_CANLF SH3 domain binding kinase 1 SBK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ELRRRPSH;FGVLIFCV;PVLELPPAWPL;RVKLADFGMTR 4 7.4 1.003 -2.4661 0 7.25786 0 0 0 0 0 0 0 0 8.49546 0 0 0 0 A0A8P0SLD2 A0A8P0SLD2_CANLF F-box and WD repeat domain containing 9 FBXW9 Canis lupus familiaris (Dog) (Canis familiaris) DVGHRSQI;LSGSRDRNV 2 3.7 1.0024 -1.3671 0 0 0 0 0 0 0 0 10.6881 0 0 0 0 0 0 A0A8P0SLD5 A0A8P0SLD5_CANLF KN motif and ankyrin repeat domain-containing protein 2 KANK2 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; negative regulation of actin filament polymerization [GO:0030837] mitochondrion [GO:0005739] DGEPTRQAASCQSQEVGGAGE;DLPEPLEDPV;EQEHGEQSAGNYA;PAESPSSPPGVEATSL 4 6.2 0.98953 -0.27382 0 0 0 0 0 0 0 0 0 11.2417 0 0 0 0 0 A0A8P0SLH6 A0A8P0SLH6_CANLF Non-POU domain containing octamer binding NONO Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] RNA binding [GO:0003723] RKQLELRQEEERRRREEEMRRQQEE 1 5.3 0.99035 -0.29865 10.4936 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SLK3 A0A8P0SLK3_CANLF Chromosome 7 C1orf43 homolog C7H1orf43 Canis lupus familiaris (Dog) (Canis familiaris) Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739] PTTIQVTYLPS 1 4.3 0.98089 0.035491 0 10.0928 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SLK7 A0A8P0SLK7_CANLF Immunoglobulin superfamily DCC subclass member 3 IGDCC3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAKAPCPGPAATLPPQ;LLLPLLLLL;PCDCRKEEATNQTSTTG;RRPRLLLPLLL 4 5.7 0.99547 -0.15374 0 0 0 5.50064 4.44268 0 0 0 0 0 0 8.67342 0 0 0 A0A8P0SLL0 A0A8P0SLL0_CANLF Linker for activation of T cells LAT Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] CEDNDEDEE;DDDDDDDDEEEEGAPD;DDDDDEEE;DNDDDDDDDDEEEE;EDNDDDDDDDDEEEE;EDNDDDDDDDDEEEEGAPDYENL;ELPGSYDS;EVEDNDDDDDDDDEEEEGAP;LAGTDPAIL;LSSQEVEDNDDDDDDDDEEEE;NDDDDDDD;NDDDDDDDDEE;NDDDDDDDDEEEEGAPDY;NDDDDDDDDEEEEGAPDYEN;NEEHLSCEDNDEDEEEEYHNEG;SCEDNDEDEEEEYHNEGYLEVL;SQEVEDNDDDDDDDDEEE;SSQEVEDNDDDDDDD;VEDNDDDDDDDDEEE;VVLIPYMLG;YVNVSQELPSL 21 37.4 1.0028 -0.86274 11.9316 7.68096 0 8.26796 0 0 10.2317 7.29976 9.41543 0 10.9779 4.21708 0 0 9.23103 A0A8P0SLM5 A0A8P0SLM5_CANLF Carboxypeptidase (EC 3.4.16.-) SCPEP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type carboxypeptidase activity [GO:0004185] LVMWLQGGPG;VHLYQRHVR;YKNLAFYWILRA 3 6.9 1.0044 -1.0933 10.084 0 0 0 0 8.02956 0 0 0 0 0 0 0 0 11.4708 A0A8P0SLM8 A0A8P0SLM8_CANLF Elongation factor Tu TUFM Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] GTAPLDGC;QRFTLRDGNRTIG 2 4.7 1.0042 -1.0445 9.0574 8.8657 0 0 0 0 10.2085 10.4823 10.0423 0 0 0 0 0 0 A0A8P0SLN2 A0A8P0SLN2_CANLF Low-density lipoprotein receptor LDLR Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869] clathrin-coated pit [GO:0005905]; late endosome [GO:0005770]; low-density lipoprotein particle [GO:0034362] calcium ion binding [GO:0005509] AECLDASDESQETCM;CDGGPDCK;DGQMDCENGSDEQ;DGQMDCENGSDEQGC;HGSRQCDKEYDCKDMSDEI;IQWPNGIT;LYIILPIVLLILL;MDCENGSDEQGCPPKTC;SLVTEDIQWPN;VGALYIILPIVLLIL 10 10.7 0.99402 -0.19104 0 7.1633 0 0 7.11061 8.44307 4.77146 0 0 0 0 0 5.28021 5.08091 0 A0A8P0SLN8 A0A8P0SLN8_CANLF Netrin-1 NTN1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] EPEDCDSYC;RGEERLRSCHLCNASDP;TLDGRPSAHDFDNSPVLQDWV;YNRPHRAPITKQ 4 10.6 1.0033 -1.0257 0 0 0 0 0 0 0 9.21692 6.39424 0 0 0 0 2.92071 0 A0A8P0SLP1 A0A8P0SLP1_CANLF Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1) SLC24A1 Canis lupus familiaris (Dog) (Canis familiaris) visual perception [GO:0007601] plasma membrane [GO:0005886] "calcium, potassium:sodium antiporter activity [GO:0008273]" PHANTENKQEEEESAE;VIGEEVEAPGG 2 2.8 0.94838 0.084724 0 0 0 0 6.12619 0 0 0 0 8.30538 0 0 0 0 0 A0A8P0SLQ0 A0A8P0SLQ0_CANLF Coronin CORO2B Canis lupus familiaris (Dog) (Canis familiaris) EISTEKPFLS;LKGLIEPISMI;PLIEEEIDGL;YPKVCGHQGNVLD 4 10.1 1.003 -1.497 0 0 0 0 8.44741 11.7641 4.72219 0 0 0 0 0 9.47196 0 0 A0A8P0SLQ4 A0A8P0SLQ4_CANLF Neuromedin U receptor 2 NMUR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuromedin U receptor activity [GO:0001607] FLTECHLV;HIDRLFFSF 2 4.5 1.0022 -0.76992 9.72566 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SLS3 A0A8P0SLS3_CANLF Intercellular adhesion molecule 4 ICAM4 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] integrin binding [GO:0005178] LPEDSGLS;PGWVSYQL 2 5.9 0.99668 -0.57806 0 0 0 8.1822 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SLT3 A0A8P0SLT3_CANLF BTB domain containing 7 BTBD7 Canis lupus familiaris (Dog) (Canis familiaris) morphogenesis of a branching epithelium [GO:0061138] EFGLADAAAELLQNP;EGATVSYEIQI;RMVRMSNVP;SGLATLKKKFIKRR;SLGRGAQQNTDLER 5 5.6 0.93709 0.060769 0 0 0 0 0 0 3.91734 0 0 0 0 0 0 0 0 A0A8P0SLU6 A0A8P0SLU6_CANLF Family with sequence similarity 181 member A FAM181A Canis lupus familiaris (Dog) (Canis familiaris) AALDKSAPCRRSV 1 3.9 0.74294 0.24233 12.9637 0 0 11.2395 0 11.092 12.9882 13.0486 0 12.4108 10.0069 12.4949 0 12.8789 0 A0A8P0SLW0 A0A8P0SLW0_CANLF Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2) KATNAL2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule severing [GO:0051013] cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017] ARRKNLLILILHYLTQ;GVLSQETEGYSG 2 5.2 0.93323 0.099673 0 0 0 0 4.38232 0 0 0 0 8.19106 0 0 0 0 0 A0A8P0SLW8 A0A8P0SLW8_CANLF N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) PIGL Canis lupus familiaris (Dog) (Canis familiaris) TLQSVNVLRKYISL;VIAHPDDEAMFFAPTVLGLAR 2 14.3 0.98994 -0.21236 0 0 0 0 0 9.76237 0 0 0 0 0 0 9.766 0 0 A0A8P0SLZ3 A0A8P0SLZ3_CANLF Corticosteroid-binding globulin (Serpin A6) (Transcortin) SERPINA11 SERPINA6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867]; steroid binding [GO:0005496] LALCTYFLWLSTSYLLTV 1 4.5 0.97366 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 7.69572 0 0 A0A8P0SLZ9 A0A8P0SLZ9_CANLF Interleukin enhancer binding factor 3 ILF3 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725] GGGGGGGG;SQGGYGRNADHSMNYQY 2 3 0.98546 0.046227 0 7.41591 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SM03 A0A8P0SM03_CANLF MORC family CW-type zinc finger 4 MORC4 Canis lupus familiaris (Dog) (Canis familiaris) ATP hydrolysis activity [GO:0016887]; zinc ion binding [GO:0008270] AFCGILYMKPRM;LPSLEAILNYS;VGVAKGVR;VGYDLYKPTFTN 4 4.8 1.0021 -1.283 9.24634 11.1516 0 0 0 0 4.65409 0 0 0 0 0 3.54387 0 0 A0A8P0SM08 A0A8P0SM08_CANLF NADPH oxidase 5 NOX5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509]; oxidoreductase activity [GO:0016491] CPMDCDPKPLS;LFHYRPGDYL 2 2.9 0.9854 -0.4436 13.3677 0 0 0 0 0 0 8.40595 0 0 0 0 0 0 0 A0A8P0SM10 A0A8P0SM10_CANLF BRCA1 interacting helicase 1 BRIP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleus [GO:0005634] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]" AKIRVQEQQ;ETFEFQDEVGA;KPVSWSNFNSLERYFTGE;LDSMVNNNI;PPGHCSRCCCS;SEEFAQAVKAEKNVISRSTS;TFPYKAYPSQLAMMNSI 7 7.6 1.0044 -1.0466 0 0 9.60338 0 0 0 0 9.8467 7.39541 0 0 8.32526 0 0 0 A0A8P0SM27 A0A8P0SM27_CANLF "Family with sequence similarity 199, X-linked" FAM199X Canis lupus familiaris (Dog) (Canis familiaris) EEPGCLDISDFGCQL;KRSKQRKLQQKALRKR;NLDELPWSAMTNDE;PCLLPKKKNKHRNLDEL;SISTYWDWSDSE;SVGDQDDCYSL 6 20.6 0.98646 -0.38705 9.33827 0 0 0 0 0 0 0 7.45886 0 0 0 0 5.90386 0 A0A8P0SM30 A0A8P0SM30_CANLF Outer dense fiber of sperm tails 3 like 1 CIMAP1C ODF3L1 Canis lupus familiaris (Dog) (Canis familiaris) ARNSVFYGQHPEEEVQVPSWQEI;SLSSEHKS 2 11.3 1.0028 -1.3785 10.5371 0 0 0 0 0 0 0 0 0 7.7845 0 0 0 0 A0A8P0SM36 A0A8P0SM36_CANLF Delta like non-canonical Notch ligand 1 DLK1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509] DGNLCDIDIRACASAPC;TPGVHELPVP 2 7 0.98682 -0.49997 0 0 0 0 0 10.069 0 0 0 0 0 0 0 0 8.30154 A0A8P0SM37 A0A8P0SM37_CANLF Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) RBM22 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; RNA binding [GO:0003723] TSLGSNTYNRQN;TTPYYKRNRPHICSFWVKGE 2 7.8 0.98652 -0.45603 9.44099 0 0 0 0 0 9.17033 0 9.28993 9.93961 0 0 0 0 0 A0A8P0SM81 A0A8P0SM81_CANLF Retinoic acid induced 1 RAI1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] GQRARVPKP;LDATGASLAT;LEAEEEYSSLCE;LSDRPLHALKR;SKRRRPSESRLP;THAEPPETDYLSGSEDPLE;VVSKALSTSCLVCCLCQNP 7 5 1.002 -1.2477 0 0 0 6.39823 0 0 9.93586 12.0836 10.9917 0 10.5169 4.008 8.09059 9.16862 0 A0A8P0SM96 A0A8P0SM96_CANLF Zinc finger protein 300 ZNF300 LOC119863914 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DVISKLEQGEDPWIIKRDIPNW;LVSMGYPVSKPDVIS 2 5.5 0.98805 -0.34088 0 0 0 0 0 0 0 0 0 9.43267 0 0 0 0 0 A0A8P0SMA2 A0A8P0SMA2_CANLF Synaptopodin SYNPO Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] AEEILPEWASCLK;ASLYHGYLPENGV;LPAPPRPF;SEEEEVPLVVYLK 4 4 0.98984 -0.22003 0 9.10476 8.93979 0 0 10.1642 9.29705 0 0 8.85935 0 0 0 11.3525 0 A0A8P0SMA5 A0A8P0SMA5_CANLF Tetratricopeptide repeat domain 39C TTC39C Canis lupus familiaris (Dog) (Canis familiaris) AGVIETIKNKIKKNVDAR;EEEKMQLACDDLKTTEKL;GASFVSFLNAMMTFEEEKM;KEILLKKEAAY;SGYDFENRLHVRIHAA;YLWKALPNCSFPNLQ 6 15.8 0.98324 -0.2524 0 9.7818 0 0 4.96555 9.63679 0 8.92955 10.9917 0 0 9.24669 0 4.26288 0 A0A8P0SMA6 A0A8P0SMA6_CANLF DUF4524 domain-containing protein C4H5orf34 Canis lupus familiaris (Dog) (Canis familiaris) DQLIQIEHPGPYER;GIICMQSGTVKISSLDGH;GVTYRLTH;LPVLLRESVIP 4 8 1.0021 -0.95944 0 7.31461 8.56529 0 0 0 0 7.66242 0 0 4.78581 0 0 10.4917 0 A0A8P0SMB4 A0A8P0SMB4_CANLF C-C motif chemokine CCL14 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] APTRPALHLQQ 1 8.2 0.98417 -0.25512 0 0 0 0 0 0 0 0 0 12.1875 0 0 0 0 0 A0A8P0SMC0 A0A8P0SMC0_CANLF calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) CAMK2A Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683] HGRRRKRV;RVGIRRNV;SLPPTICLSSSL 3 4.1 1.003 -1.6597 0 0 0 0 0 0 0 0 0 0 0 0 7.78934 0 0 A0A8P0SMC1 A0A8P0SMC1_CANLF A-kinase anchoring protein 17B AKAP17B Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ALRLLRVLLRKIAVRLFL;EALRLLRVLLRKIAVRLFLNPSSL;ELTDFLEEISSDSE;EPMRPFSNWEVLDQLKSLICPD;LAQRRVEALRLLRVLLRKIAVRL;LLTDGYNHSVVSDQNSLQN;LRLLRVLLRKIAVRLFLN;MLKGDDGKA;RKAREKRKKARVRRRGLKERDR;SLVQILKAKLHGKIIKLNGLKTDLK;SQEHIDYRSYLGSSYTSSLYF 11 17.4 0.98947 -0.51027 6.77768 6.74133 0 0 0 5.66849 9.4064 5.32355 4.2791 0 0 8.615 0 0 8.39938 A0A8P0SMD7 A0A8P0SMD7_CANLF Sodium/mannose cotransporter SLC5A10 (Sodium/glucose cotransporter 5) (Solute carrier family 5 member 10) PRPSAP2 SLC5A10 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transport [GO:0006814] plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] CTDQVIVQRSL;LGSIHYLHFAVALFV;QGAFWGLMVG;SLFASSEGS;SLFASSEGSG 5 8.2 0.99794 -0.098083 10.6068 9.84698 0 0 10.2624 0 0 0 0 10.6969 10.6849 10.6783 6.36762 9.98314 0 A0A8P0SMF0 A0A8P0SMF0_CANLF Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) DDX52 Canis lupus familiaris (Dog) (Canis familiaris) maturation of SSU-rRNA [GO:0030490] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] AIPVMLHGREL;IPVMLHGREL;QDEEKKEESLTERKRE;VETVEQELLFVGSET;VIHADRTQQQR;VIQQAGCPVPEYIKGFQK 6 11.9 1.0028 -0.72187 0 0 0 9.51456 0 0 0 0 0 0 5.54797 0 10.1767 11.0269 0 A0A8P0SMF9 A0A8P0SMF9_CANLF Adhesion G protein-coupled receptor E1 ADGRE1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] plasma membrane [GO:0005886] calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930] CTDIDECSQDPS;GIMTGEKKDG 2 2.1 0.95544 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.06727 A0A8P0SMI0 A0A8P0SMI0_CANLF BTB domain containing 6 BTBD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] IHIPDVEP;PAGGGAGP;RSNQWRYRGRCDSIQ;VGAAGRTPWGPAGPAPAPD;VTCGRRGGRGE 5 8 0.98802 -0.2608 0 0 8.90044 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SMI7 A0A8P0SMI7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AGPLPEPLGG;ALQNHYTDLSLSHSPG;DEDGSYFL;DEDGSYFLYSKL;DEDGSYFLYSKLSVDKSR;DLSLSHSPG;EALQNHYTDLSLSHSPG;EDGSYFLYSKL;EVQISWFVDGKEQ;FLYSKLSVDKSR;FPSVLQSSGL;GEQAGGRSAGVTQDLREQGAG;GSLTSGVHTFPSVL;GSLTSGVHTFPSVLQSSGL;GSYFLYSKL;GVHTFPSVL;GVHTFPSVLQSSG;GVHTFPSVLQSSGL;HTFPSVLQSSGL;HYTDLSLSHSPG;IFPPKPKD;KLSVDKSR;LPSPIERTISKARG;LQNHYTDL;LQNHYTDLSLSHSPG;LSLSHSPG;LTSGVHTFPSVL;LTSGVHTFPSVLQSSGL;LYSKLSVD;LYSKLSVDKSR;LYSLSSMVTVPSSR;NHYTDLSLSHSPG;NSGSLTSGVH;NSGSLTSGVHTF;NSGSLTSGVHTFPS;NSGSLTSGVHTFPSVL;NSGSLTSGVHTFPSVLQ;NSGSLTSGVHTFPSVLQS;NSGSLTSGVHTFPSVLQSSG;NSGSLTSGVHTFPSVLQSSGL;QNHYTDLSLSHSPG;QSSGLYSLSSM;SGSLTSGVHTFPSVL;SGSLTSGVHTFPSVLQS;SGSLTSGVHTFPSVLQSSGL;SGVHTFPSVL;SGVHTFPSVLQSSGL;SKLSVDKSR;SLSSMVTVPSSR;SLTSGVHTF;SLTSGVHTFPSVL;SLTSGVHTFPSVLQ;SLTSGVHTFPSVLQS;SLTSGVHTFPSVLQSSG;SLTSGVHTFPSVLQSSGL;SLTSGVHTFPSVLQSSGLY;SLTSGVHTFPSVLQSSGLYSLSSM;SMVTVPSSR;SSGLYSLSSM;SSMVTVPSSR;SYFLYSKL;SYFLYSKLSVDKSR;TDLSLSHSPG;TFPSVLQSSGL;TPPQLDEDGSYFL;TSGVHTFPSVL;TSGVHTFPSVLQSSGL;TYRVVSVL;VGAAEPPGP;VHTFPSVL;VHTFPSVLQ;VHTFPSVLQSS;VHTFPSVLQSSG;VHTFPSVLQSSGL;VHTFPSVLQSSGLYSLSSM;VTVPSSRWPSET;VTVSWNSGSLTSGVHTFPSVL;YFPEPVTVS;YSKLSVDK;YSKLSVDKS;YSKLSVDKSR;YSKLSVDKSRWQQ;YSLSSMVT;YSLSSMVTVPS;YSLSSMVTVPSS;YSLSSMVTVPSSR;YTDLSLSHSPG 87 38.8 1.0024 -0.72299 0 8.75272 8.96564 10.7759 0 0 0 0 0 0 0 0 8.80735 0 0 A0A8P0SMJ8 A0A8P0SMJ8_CANLF Mitochondrial ribosomal protein S30 MRPS30 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] mitochondrion [GO:0005739]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] AQAMYQGFWSEAD;PLFKRQFEN 2 5.2 1.0017 -0.74437 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4098 6.81365 A0A8P0SMJ9 A0A8P0SMJ9_CANLF Cytokine receptor like factor 3 CRLF3 Canis lupus familiaris (Dog) (Canis familiaris) GVCAEKQNGYDSLQRD;GVLYSSAP;RESVEAAQSYRRELGQ;TLLQEVDTIEQ 4 11.6 1.0044 -1.0516 0 0 0 9.99308 0 0 9.10279 0 0 0 0 0 0 0 7.94696 A0A8P0SMN0 A0A8P0SMN0_CANLF Zic family member 3 ZIC3 Canis lupus familiaris (Dog) (Canis familiaris) EQGAGHPSPTG;GAPRHHEMPNRE;GVGSFGAP;SSPAASSGYE;THPSSLRKHMK 5 10.5 1.0023 -1.0185 5.71973 0 0 0 0 0 0 6.97361 0 0 0 0 8.59096 9.651 0 A0A8P0SMN4 A0A8P0SMN4_CANLF Phospholipase A2 (EC 3.1.1.4) PLA2G10 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623] DWCCHQHDCCY;IDWCCHQHDCCYM;PPLLLLLL;PPLLLLLLL 4 14.4 0.9236 0.095052 0 0 0 0 0 0 0 4.24853 0 0 0 0 0 3.82528 0 A0A8P0SMU1 A0A8P0SMU1_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) QFLAKVSGTPRAHSLER 1 6 0.98439 -0.23955 0 0 0 0 0 0 0 0 8.34132 0 0 0 0 0 0 A0A8P0SMU8 A0A8P0SMU8_CANLF Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) CPD Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AGPPRRPGRLLLLLLLLLL;CKNMYPNEYFPHGITNG;FDLNRNFPDQFF;HHDEYEDE;ISNKPNISEPEEP;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLQ;LSHEFQDETDTEE;PFQQPIQPKDFHHHH;RLLLLLLL;RLLLLLLLL;RRPGRLLLLLLLLLLQ;TYGHCPEITVY;VLTGYMPLT;VTGSGLENATIS;VVGRELLLNLIEYLCKNFGT 18 10.9 1.0035 -1.6074 0 0 9.20014 4.77837 0 0 5.19468 0 8.95428 8.7848 0 0 10.3413 0 0 A0A8P0SMU9 A0A8P0SMU9_CANLF Muscleblind like splicing regulator 3 MBNL3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] KMMRSDKLEVCREFQ 1 5 0.98773 -0.2278 0 0 0 10.1389 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SMV0 A0A8P0SMV0_CANLF "Alpha-1,3-glucosyltransferase (EC 2.4.1.-)" ALG6 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] hexosyltransferase activity [GO:0016758] LSEIPFMSTWFLLV;VFLKIKDILPHHIQ;VLSEIPFMSTWFLLVS 3 6.6 0.85609 0.17131 0 0 0 6.97166 9.08465 6.63161 0 0 4.29829 0 0 0 0 0 0 A0A8P0SMV4 A0A8P0SMV4_CANLF CD320 molecule CD320 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CDGDEDCPDGSDED;DEDCPDGSDEDEC;EDECRIKPCAQDGECLPV;SPCPCDNIDDCRDGIVDNVYNCSY;TLRCDGDEDCPDGSD 5 22.1 0.98451 -0.24172 9.03642 0 0 0 0 0 0 0 8.66388 0 0 0 0 0 0 A0A8P0SMV5 A0A8P0SMV5_CANLF Centrosomal protein 192 CEP192 SEH1L Canis lupus familiaris (Dog) (Canis familiaris) centrosome duplication [GO:0051298]; centrosome-templated microtubule nucleation [GO:0090222]; protein localization to centrosome [GO:0071539] CGFSGSCPYPAVAGEHVQN;DIHTVDLGAT;DIHTVDLGATNKNIREPEENTV;DIWDLSLPKEQTTQDIHTV;LARVDIEVDSPNP;LENHGNAEVKWHL;PVVSAMPHLPV;SETTHKESEVGHVVCLPG;SLEDSSDDDIDDEE;WHLSSLAP 10 5 0.95121 0.049654 0 0 0 0 0 0 0 8.99568 0 0 0 0 0 0 0 A0A8P0SMV6 A0A8P0SMV6_CANLF RalA binding protein 1 RALBP1 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267] KGKFKKKEK;KHKEEKHKEKKSKDL;VEKYGMKCEGI 3 5.4 0.98508 -0.25928 0 0 0 0 2.87639 0 0 0 0 0 3.28983 0 0 7.04843 0 A0A8P0SMV8 A0A8P0SMV8_CANLF Solute carrier family 25 member 14 SLC25A14 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] PGAGHQAL 1 2.4 1.0035 -1.1044 0 0 11.7475 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SMY4 A0A8P0SMY4_CANLF Sodium channel epithelial 1 subunit delta SCNN1D Canis lupus familiaris (Dog) (Canis familiaris) sensory perception of taste [GO:0050909] plasma membrane [GO:0005886] ligand-gated sodium channel activity [GO:0015280] FPSVTLCDMNPHRPRSACHHL;GTSRWPSSKSADWILSALGK;PSGAEYCSYT;RAHSSGVTA 4 9.9 0.98604 -0.4151 0 0 8.30875 0 0 0 12.1753 0 7.26106 0 0 0 7.47557 0 0 A0A8P0SMY9 A0A8P0SMY9_CANLF Complement C8 alpha chain C8A Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; killing of cells of another organism [GO:0031640]" extracellular region [GO:0005576]; membrane attack complex [GO:0005579] IVLDEGMLQSLMELPEQYNYGM;KDCLDGSDEDDCEDVRVAENDC;LDQYLMEFNA;LSNWSEWTDCFPCQDKKYRYRSL;NNFVSTGVTVGVSFT;QNGGASCP;STITYRSWGRSLKYNPVVIDFE 7 20.7 0.98518 -0.25796 0 0 7.52873 0 0 0 8.94965 0 0 8.10795 0 0 10.5889 0 9.97828 A0A8P0SN37 A0A8P0SN37_CANLF Cadherin-6 CDH6 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEALIHPTGLS;DDPTYGNSAKVVYSIL;EEKPVYILRAQAINRR;GLDMFDVVTDQ;GVITVKKLLDFEKKKV;VLFAALRRQRKKEPLIISKEDIRD 6 12.8 0.97108 0.041303 0 0 0 0 4.74927 0 0 0 0 0 0 0 0 0 0 A0A8P0SN41 A0A8P0SN41_CANLF Plexin B3 PLXNB3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] AVIAQTFIDSCTV;EDGEEGGV;EQVYKGTPFSQRPSAHALD;GGAAGGGA;NDSRLLREDVEFR;SPAVPDGVHPQ;SPRIDRIEPLTGPP;VCHTMSQASPGEA 8 5.2 1.0011 -0.94482 0 9.66649 0 3.24021 0 0 3.5064 0 11.0989 0 0 0 0 8.0031 0 A0A8P0SN49 A0A8P0SN49_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VTVVGNVLIILAISFDPRLHT 1 6.8 0.97782 0.047591 8.54531 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SN51 A0A8P0SN51_CANLF N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase NAGPA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATVEETARAAGCRVA;CQRPCECE;CSNSSFGEDCAMKCRCQNG 3 7.4 1.0028 -1.3451 0 0 0 0 0 0 0 5.50316 0 0 8.93605 0 0 6.91277 0 A0A8P0SN55 A0A8P0SN55_CANLF Splicing factor Cactin CACTIN Canis lupus familiaris (Dog) (Canis familiaris) ELKERNKRIQEDNRLELQKVKQ;EWEYSHRH;KEAEHFKTWEEQEDNFHLQ;KPRFFNRVHTGFEWNKYNQTHYDF;MGWGEEYMGYTN;REWEYSHRHG;TVGLSVLPALPP 7 12.6 1.0038 -0.82259 0 0 7.58676 0 8.82849 0 11.7859 0 11.17 0 11.5046 0 0 0 10.9866 A0A8P0SN57 A0A8P0SN57_CANLF Gamma-aminobutyric acid type A receptor subunit alpha3 GABRA3 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] TVILSQVSFWLNRESVP;VGTEIIRSSTEYVV 2 6.3 0.93967 0.060962 0 0 8.87971 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SN84 A0A8P0SN84_CANLF Nuclear FMR1 interacting protein 2 NUFIP2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] HHHYYFYNHSHNH;HYYFYNHSHNHHH;LVSPTNTLLGSAKEQRYQ;PHHHPQQQQQQQQQQQQ;TVQNSSVSPSSSS;VLSSILKSGTT 6 10.5 1.0027 -1.0231 4.37705 0 0 11.0614 4.10844 0 0 0 10.5953 9.98028 11.5301 11.5008 0 0 5.26821 A0A8P0SN99 A0A8P0SN99_CANLF RNA pseudouridine synthase domain containing 1 RPUSD1 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] HQLRVHCSALSHPVVGDLTYGQAS 1 7.9 0.97457 0.041303 0 0 0 0 0 0 0 0 7.92374 0 0 0 0 0 0 A0A8P0SND8 A0A8P0SND8_CANLF Leucine rich repeat containing 26 LRRC26 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FWSLGALQQLDLSANQ;PAPEAETLLCVL 2 8.9 0.98317 -0.25633 0 11.0796 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SNE5 A0A8P0SNE5_CANLF Serpin family F member 1 SERPINF1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] IIFFLPLKVTQNLTMIEESL 1 6.6 0.96407 0.048688 0 0 0 9.50795 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SNF0 A0A8P0SNF0_CANLF Transmembrane protein 259 TMEM259 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229]; membrane [GO:0016020] ARHGSKAT;RDPLRLPSPTAPRA 2 3.5 0.98923 -0.20361 0 0 0 0 0 0 0 0 0 0 7.3535 10.8709 0 0 0 A0A8P0SNH6 A0A8P0SNH6_CANLF Ankyrin repeat domain containing 11 ANKRD11 Canis lupus familiaris (Dog) (Canis familiaris) DRGKGDKYRDKSGDKDKSE;EYVTYTGSY;LDRSDGGKEVRERA;LEPLDEGP;PEKHKDKKEKEPAEK;PSCSADDYSD;PVIAPPPSLAEPLKELFKQQEA;PVRKKQEHRK;QTSVGPHLEPSSK;SSHGSSAA;TDSEFEKGL;TKRKLPFTVGA;TLSEKKNSFHT;TPSCSADDYSDLMFDCTDPQP;VDDKYDRMK;YEFDEDDEQDRVP 16 7.3 0.99918 -3.2112 8.59716 8.36076 11.9283 0 9.78028 0 11.3663 10.5484 8.36146 11.8678 7.94439 13.2563 0 10.687 10.0568 A0A8P0SNI4 A0A8P0SNI4_CANLF General transcription factor IIIC subunit 5 GTF3C5 Canis lupus familiaris (Dog) (Canis familiaris) transcription initiation at RNA polymerase III promoter [GO:0006384] nucleus [GO:0005634]; transcription factor TFIIIC complex [GO:0000127] DNA binding [GO:0003677] DREKEQLTYESGEDEEDDEEEEED;EDEEDDEEEEEDFKPSDGSDN;EQLTYESGEDEEDDEEEEED;EQLTYESGEDEEDDEEEEEDF;ESRCTERDGWCLPKTSDELRDT;GEDEEDDEEEEEDF;LEAQPEVTFDIEILGIISTVYKF;YFYRPETQ 8 16.5 0.87603 0.12853 9.09268 7.24146 5.61565 0 0 4.35099 0 7.80064 12.1373 0 4.88078 4.47826 0 0 0 A0A8P0SNI5 A0A8P0SNI5_CANLF Major facilitator superfamily domain-containing protein 12 MFSD12 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate transport [GO:0008643] membrane [GO:0016020] symporter activity [GO:0015293] AAGAAAPPRPLSLSA;IGPHTHSGAFVY;SLPCPHWPRAAGLGQGQA 3 8.7 0.93412 0.091191 10.3385 0 0 0 0 0 0 0 0 0 0 0 9.44557 0 0 A0A8P0SNJ4 A0A8P0SNJ4_CANLF Zinc finger and BTB domain containing 48 ZBTB48 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] VSKTLGQVPRDQ 1 1.7 0.95199 0.05044 0 0 8.64591 0 0 0 0 0 0 0 0 0 8.88084 0 0 A0A8P0SNK1 A0A8P0SNK1_CANLF Cyclin dependent kinase 10 CDK10 Canis lupus familiaris (Dog) (Canis familiaris) regulation of mitotic cell cycle [GO:0007346] ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693] DSSYFKEKPLPCEPELMP;GVPISSLREITLLLRLRHPNIVELK;PWLSEAGLRLLNF;VAKARERS 4 17.2 1.0048 -1.1044 0 0 0 0 0 0 0 0 6.68187 0 0 0 0 0 0 A0A8P0SNK8 A0A8P0SNK8_CANLF Potassium voltage-gated channel modifier subfamily G member 4 KCNG4 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] VGLALRVLRALRIL;VGLALRVLRALRILYVMRLAR;VSTMPDLRAEEDKIQGVTS;VTSRHGFFLP 4 8.8 0.9969 -0.094641 0 8.38474 4.05849 4.96486 0 0 9.38098 0 0 0 0 3.32337 0 0 0 A0A8P0SNL7 A0A8P0SNL7_CANLF Period circadian regulator 3 PER3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ESMWRMIKQTPE;FRIIPYLIHVHRAAQPE;KDAEQEKHYYPFRII;LLSPSFCPY;QEMKKYFPSGRH;QQPWFSRGQRQELASVHSWIQS;QVPERVTEAVLREDLEKL;SEEDGQNH;TVMTTFLP;VSEQATLILNCKKDFLE 10 11.8 1.0037 -2.0441 0 0 0 7.60103 8.81922 0 0 0 11.7095 7.95163 0 0 0 12.3838 0 A0A8P0SNM0 A0A8P0SNM0_CANLF Leucine rich repeat containing 47 LRRC47 Canis lupus familiaris (Dog) (Canis familiaris) phenylalanyl-tRNA aminoacylation [GO:0006432] phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723] EAGGPAVL;LPLLHYLE;RRDGGGGAAAAAAP 3 4.2 1.0031 -1.5304 9.86691 0 9.93077 0 0 0 0 0 10.6501 0 0 0 0 0 0 A0A8P0SNM6 A0A8P0SNM6_CANLF KISS1 receptor KISS1R Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GPRTYCSEAFPSRA;LGDFMCKFVNYM;NSALNPLLYAFLGSHFRQA 3 11.8 0.85413 0.16647 0 0 0 0 0 0 0 0 0 5.24302 0 5.1053 8.04723 0 0 A0A8P0SNP4 A0A8P0SNP4_CANLF Zyg-11 related cell cycle regulator ZER1 Canis lupus familiaris (Dog) (Canis familiaris) LMSLDISG;RSFSHTLVSLS;SRDRLSSYYKFKLTRKVL;VLSHIMFDGP 4 6.2 0.985 -0.44418 9.19145 0 0 8.30012 0 0 0 0 0 0 0 10.9975 9.67479 0 0 A0A8P0SNS5 A0A8P0SNS5_CANLF Endosome-associated-trafficking regulator 1 ENTR1 Canis lupus familiaris (Dog) (Canis familiaris) ASLTVVKQ;DEDEDEDEDNGWN;DLLDEDEDEDEDNGWNGA;LLDEDEDEDEDNGWNGAY;VGDTDFGYGKGKCTKQGPPGA 5 11 0.84688 0.15619 0 0 6.74228 0 6.61368 0 0 0 5.06536 0 0 0 0 0 0 A0A8P0SNS8 A0A8P0SNS8_CANLF E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166) RNF166 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872] YDTFVVGV 1 2.2 1.0044 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 8.68559 0 0 A0A8P0SNT4 A0A8P0SNT4_CANLF Leucine rich repeat containing 39 LRRC39 Canis lupus familiaris (Dog) (Canis familiaris) EERELFGLQFMHAY;LDMGSNKLE 2 6.9 0.99293 -0.15073 0 10.5994 0 0 0 0 0 0 0 0 0 4.8678 8.11223 0 0 A0A8P0SNT7 A0A8P0SNT7_CANLF TNF receptor associated factor 7 TRAF7 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] IKVWDTCTTYK;NHHIVCGTY;SLPEEEEEP;TPDQTKVFSASYDR 4 6.5 1.0021 -1.2422 0 9.34578 0 0 0 9.57541 0 9.00282 9.14361 0 0 0 0 9.9538 9.0281 A0A8P0SNT9 A0A8P0SNT9_CANLF Solute carrier family 7 member 5 SLC7A5 Canis lupus familiaris (Dog) (Canis familiaris) neutral amino acid transport [GO:0015804] membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AEEEERQARERMLAGK;ASAAPAAAEEEERQARERMLAGK;LPAFLKLWIELLIIRP;RYKKPELERPIKFPRRSCA 4 12.3 0.99099 -0.26943 0 4.20828 0 10.0884 0 0 0 10.6738 0 0 0 0 10.0353 0 7.7701 A0A8P0SNZ0 A0A8P0SNZ0_CANLF protein kinase C (EC 2.7.11.13) PKN3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] LRRVATDRRHLGHVQQ;NVVKLLGGQRTQDRKALAEAQA 2 4.3 0.98795 -0.22417 0 0 8.13453 0 0 0 0 0 11.0185 0 0 0 0 0 0 A0A8P0SNZ3 A0A8P0SNZ3_CANLF Ataxin 7 like 2 ATXN7L2 Canis lupus familiaris (Dog) (Canis familiaris) EAEAPSRKRKL;LSPKERKLD;SSPLSAPLSPSS 3 4.2 0.98972 -0.30704 0 0 0 0 0 0 0 8.94272 8.47938 0 0 0 0 0 0 A0A8P0SNZ7 A0A8P0SNZ7_CANLF TruB pseudouridine synthase family member 2 TRUB2 Canis lupus familiaris (Dog) (Canis familiaris) pseudouridine synthesis [GO:0001522]; RNA processing [GO:0006396] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723] GKATDDFCED;GSHQKALVMYSNLDLQ;LTNHPLVCGPAFTS 3 12.6 1.0017 -0.69291 0 0 0 0 0 0 10.3048 7.80948 0 0 0 0 0 6.53141 6.15194 A0A8P0SP00 A0A8P0SP00_CANLF CBFA2/RUNX1 partner transcriptional co-repressor 3 CBFA2T3 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714] DALTVINQQEDSSESCWNCGR;EEAVNEVK;FMPRTLSGYMPEEIWRK;SSPIDSSELLLE 4 9.3 0.84985 0.1501 0 0 0 0 0 8.55601 8.04275 5.85838 0 0 0 0 0 0 0 A0A8P0SP03 A0A8P0SP03_CANLF Transmembrane protein 231 TMEM231 Canis lupus familiaris (Dog) (Canis familiaris) ciliary membrane [GO:0060170] MQSMAFLQ;SGGLDVRYNV;SILLIFLWVFERIKR;VISYQPGFWEMIKF 4 14.9 1.0015 -0.69607 0 0 0 9.5378 0 0 9.79312 8.45175 0 0 0 0 0 10.0849 0 A0A8P0SP24 A0A8P0SP24_CANLF Elongation factor 1-alpha Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746] ISVWNGDNMLE;PGHRDSIKN 2 4.4 0.99228 -0.54076 0 0 0 0 0 0 11.8596 0 0 0 0 0 0 0 0 A0A8P0SP31 A0A8P0SP31_CANLF Leucine rich repeat containing 8 VRAC subunit A LRRC8A Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] VELEVLKLE 1 1.2 1.0035 -0.80421 0 0 0 0 0 0 0 0 0 10.4066 0 0 0 0 0 A0A8P0SP38 A0A8P0SP38_CANLF Leucine rich repeat containing 8 VRAC subunit C LRRC8C Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] plasma membrane [GO:0005886] FEITELQSLKLEIIKNVM;LIHTLVFMLCSN;LTELELVHCDLERI;PAFRVLKPWWD 4 6.8 0.98734 -0.36539 0 0 0 0 0 0 0 0 9.83235 0 10.1211 0 0 0 0 A0A8P0SP85 A0A8P0SP85_CANLF Translin associated factor X interacting protein 1 TSNAXIP1 Canis lupus familiaris (Dog) (Canis familiaris) DAWKQRLVEEQKEKFPDF 1 2.6 0.9766 0.048313 0 0 0 0 0 0 0 9.56453 0 0 0 0 0 0 0 A0A8P0SPB0 A0A8P0SPB0_CANLF Zinc finger CCHC-type containing 14 ZCCHC14 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270] GCVVCTSCGCSGSCGS;PIKLLVSSSVPA;PRTEAPVSSVSNSL;SSSGGGGG;TGAEPTNLHRTPTDGTPRQ;TSCGCSGSCGSSG;VEIHLEGS;VGSSNGTG;VTGILRCL 9 9 1.003 -1.3794 0 9.68685 0 0 7.59171 0 0 10.842 10.1592 11.1792 0 0 0 5.96989 4.41197 A0A8P0SPB2 A0A8P0SPB2_CANLF Membrane dipeptidase LOC489748 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] side of membrane [GO:0098552] metallodipeptidase activity [GO:0070573] DFPLVDGHNHLP;GVLQCNLFANTSTVAD;GVLRGNLLRVFRQVEQVR;PPLRLLLL;SLDSSLSVLRGFY 5 14.7 1.0018 -1.2063 0 3.79452 0 0 0 0 0 6.84787 9.83924 5.42727 5.07942 8.85134 0 0 0 A0A8P0SPH2 A0A8P0SPH2_CANLF Transmembrane serine protease 6 TMPRSS6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] serine-type endopeptidase activity [GO:0004252] ALRRQKYDL;ATEISKRKVRDYLRLVPLWLALVVL;EDRSCVKKPNPQCDGL;VCRATFQCQED 4 7.8 1.0017 -1.2586 0 5.44586 11.9701 0 5.69452 0 0 0 0 11.382 0 0 0 0 0 A0A8P0SPI7 A0A8P0SPI7_CANLF Teashirt zinc finger homeobox 1 TSHZ1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FGGAGGAP;GGGGGGSG;LTVHMNETGHYR 3 2.6 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 10.6545 0 0 0 0 A0A8P0SPI8 A0A8P0SPI8_CANLF Cyclin dependent kinase like 4 CDKL4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CDHTLLNELERNPKGVADGV;HLVFEYCDHTLLNELERNPK 2 7.6 0.9918 -0.18663 0 0 7.81602 0 0 0 0 0 0 0 6.84536 0 0 0 0 A0A8P0SPI9 A0A8P0SPI9_CANLF TATA-box binding protein associated factor 9 TAF9 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] nucleus [GO:0005634] protein heterodimerization activity [GO:0046982] DDDDDDDDDDDD;DDDDDDDDDDDYDN;DDDDDDDDDYDN;EDDDDDDD;EDDDDDDDDDDD;EDDDDDDDDDDDD;EDDDDDDDDDDDDYDN;REDDDDDDDDDDD;REDDDDDDDDDDDD 9 6.4 0.67677 0.28077 5.32445 0 4.71518 5.72511 0 5.05028 7.59559 0 0 0 0 0 0 0 0 A0A8P0SPJ9 A0A8P0SPJ9_CANLF ALF transcription elongation factor 2 AFF2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] EACGASLTLGSLVSSSTNNSV;EEATTICLLPPC;EWPRDSQSASTVPASQ;PTLKPSIEFENSFGNLSF;VGVVEESNASAKEDGS;VQVKVKTNPSQV 6 7.5 1.0038 -1.0381 0 0 0 0 0 10.8049 0 10.1292 0 0 0 0 7.488 0 9.43359 A0A8P0SPK7 A0A8P0SPK7_CANLF Bromodomain testis associated BRDT Canis lupus familiaris (Dog) (Canis familiaris) EKRLLDVNNQL;GVKQNDSPKELVKIQ;LEKVFKQQVIPSVF;LQVLSQVPFHKLKKKSKSKR;LSQVPFHKLKKKSKSKREKKK;SETESSSSDSSSSDSSDSESE;VFTSKPEDEDNAK 7 10.6 0.99524 -0.56333 0 7.56689 8.66313 0 0 0 12.5281 7.09075 6.11601 0 0 0 0 0 8.41155 A0A8P0SPL0 A0A8P0SPL0_CANLF Serpin family A member 1 SERPINA1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] DAVQETDAPH;DAVQETDAPHHD;DAVQETDAPHHDPEHQPA;EAIPMSMPPSVDFNKPFL;EGLQGDAVQ;EGLQGDAVQE;EGLQGDAVQET;EGLQGDAVQETD;EGLQGDAVQETDA;EGLQGDAVQETDAPH;EGLQGDAVQETDAPHH;EGLQGDAVQETDAPHHD;EGLQGDAVQETDAPHHDPE;EGLQGDAVQETDAPHHDPEHQPA;EKPFEVEHTTEEDF;FMGKVVNPTQK;GDAVQETDAPHHD;GKVVNPTQK;GLQGDAVQETDAPHHD;IIIVDRDTKSPLF;IIIVDRDTKSPLFMGKVVNPTQK;LEAIPMSMPPSVDFNKPFL;LQGDAVQETD;LQGDAVQETDAPHHD;MGKVVNPTQK;PLFMGKVVNPTQK;PPSVDFNKPFL;QETDAPHHD;QGDAVQETDAPHHD;RDTKSPLFMGKVVNPTQK;SPLFMGKVVNPTQK;TIDEKGTEAAGATFL;TKSPLFMGKVVNPTQK;VQETDAPHHD 34 22.2 0 193.8 17.1516 17.1591 17.211 15.8913 16.2405 16.364 17.845 17.798 17.8893 16.846 15.5387 16.6774 17.3201 17.3757 17.4687 A0A8P0SPL5 A0A8P0SPL5_CANLF Docking protein 6 DOK6 Canis lupus familiaris (Dog) (Canis familiaris) LEKFPDEKAAYFRNFH;LVMWPLSSL;VGEIYSLQGHG 3 11.4 0.98512 -0.44793 0 0 0 0 10.6819 0 0 0 10.1857 0 0 0 0 0 0 A0A8P0SPN1 A0A8P0SPN1_CANLF Transmembrane protein 154 TMEM154 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PASGEDSCSCGVFYI 1 6.3 0.95763 0.053878 0 0 0 0 0 7.94784 0 0 0 0 0 0 0 0 0 A0A8P0SPP3 A0A8P0SPP3_CANLF Laminin subunit alpha 2 LAMA2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995] basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] signaling receptor binding [GO:0005102] ADAVRVITFTGCMGETYFDSKPI;AEECYYDENVARRNLSLNIHGKYI;ALVSRPIRWYPNISTV;ARLIERCECPA;CDCSHLGNNCDPKTGQCICPP;CDQCCPGFHQKPW;CECEHNTCGDSCDQCCPG;CEHNTCGDSC;CEHNTCGDSCDQCC;CEHNTCGDSCDQCCP;CQECECDP;CQNCQHHTAGDFC;DCEESGQCWCQPG;DDTKVKNR;DLKADDKIYF;DLRLEPFYWKLPEQ;EAASGLLFYMARINHA;EHNTCGDSCDQCC;GAALALRLPLPLLLLLLGG;GLDAKNPLGCSQC;GYYWSAPAPYL;KDPREIDPIVTRRY;NTCGDSCDQCCPG;PGAALALRLPLPLLLLLLG;PVSRREFMTVLASLKRVLIQ;QEGGCTACD;QPSVPGGSCQPCQ;SFPKPGFVELPP;TNKSRCECEHNTCGDSCDQCC;TNKSRCECEHNTCGDSCDQCCP;YFDSKPIGLWNFRE 31 10.4 0.99779 -3.351 0 11.8268 9.25269 8.5489 0 9.47419 12.5221 8.41244 8.13263 7.69195 7.68321 0 9.95936 8.56948 9.50609 A0A8P0SPQ1 A0A8P0SPQ1_CANLF Uncharacterized protein LOC102156387 Canis lupus familiaris (Dog) (Canis familiaris) CDLTSRSQPSSV;DPSPQTQVVKS;EESENSLSFESQHSLKPSYL;EFLARPMKQDMKSLE;ERRCRSPSERSHRSTSQKSHHI;ESEALITKSLHHVPESPEMTS;ESKLPCVNSTGCKLGPPLQ;ETHVESRKVTMEPHL;IQNLFGVPAELMKP;ISSSTSSVFV;ITGAKRHV;KGVKSELNP;KSVPLTPGPR;KTDFSEQFQLLQDL;LQDIQSVGFE;LTSEPKHQ;PSQKSHHSASERRHH;PVALGSPMGMIIASQS;QDTKSVELAPG;QDVRFSDL;QSQIVETPDLTSRP;SAPELQLQVVNSD;SLQSSPRAQLQGV;SMVFNPDR;TEFNFGPQLQNV;TPQPYHQRTETMAL;TSASLRRQ;VGGRNLHGSPHRTS;VGHTESVELT;VGLTSRQWLQRRQ;VGPQFKVAESV;VRPSEFTSELWLQ;WAQEYILWSMNRSLQ 33 7.5 0.99702 -7.326 10.9635 11.2697 10.4378 11.6796 9.03351 8.48587 11.9972 11.7913 10.0093 0 10.9529 14.4647 0 11.2363 6.17303 A0A8P0SPQ2 A0A8P0SPQ2_CANLF Adhesion G protein-coupled receptor F3 ADGRF3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DLDWFLRPPGSP;GEVIMDFGGTDSTSH;PAESSLPERRQ;SLVSCWLQILSSPAE 4 4.8 0.98741 -0.33761 0 0 0 8.10973 7.33914 8.0511 8.447 0 0 0 8.86518 0 0 0 0 A0A8P0SPR1 A0A8P0SPR1_CANLF DnaJ heat shock protein family (Hsp40) member A2 DNAJA2 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457]; response to heat [GO:0009408] membrane [GO:0016020] ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] EQGLREGSGGG;IGLVEALCGFQFT;QFTFKHLDGR 3 7.5 1.0028 -0.73293 0 0 0 0 0 0 0 11.5397 7.30852 0 0 8.27766 0 0 0 A0A8P0SPS1 A0A8P0SPS1_CANLF Olfactory receptor OR13D2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVLLAVMAYDR;EFILQGLSEYPRVEK 2 8.6 0.95227 0.053899 0 0 0 0 0 0 6.60066 0 0 0 0 0 0 0 0 A0A8P0SPT4 A0A8P0SPT4_CANLF XLR/SYCP3/FAM9 domain-containing protein LOC102152531 Canis lupus familiaris (Dog) (Canis familiaris) GEGSPPAG 1 2.4 0.98924 -0.2632 0 0 0 0 0 0 0 0 0 9.74774 0 0 0 0 0 A0A8P0SPW2 A0A8P0SPW2_CANLF "Myb related transcription factor, partner of profilin" MYPOP Canis lupus familiaris (Dog) (Canis familiaris) TTRLRKPRFS;VGRAARGRRAPASA 2 5.1 0.99715 -0.5972 0 0 11.3811 0 0 0 0 0 0 10.6417 0 0 0 0 0 A0A8P0SPX6 A0A8P0SPX6_CANLF "RAB34, member RAS onco family" RAB34 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] SPIVHHQFDWCLRKE;VSSLTGENVREFFFRVAA 2 10.8 0.99527 -0.083601 0 0 0 0 0 0 0 0 0 0 0 0 9.68277 6.79129 0 A0A8P0SPY4 A0A8P0SPY4_CANLF Glycine N-acyltransferase-like protein (EC 2.3.1.-) GLYATL3 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] glycine N-acyltransferase activity [GO:0047961] NLDHYTNAYAVFYKDVRAYQQLL 1 8.2 0.97911 0.046273 0 0 0 0 0 0 9.37777 0 0 0 0 0 0 0 0 A0A8P0SPY7 A0A8P0SPY7_CANLF SURF1-like protein SURF1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] PDTRQRGQVEGEVDLVGMVRLTE 1 7.6 0.97743 0.046334 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.472 A0A8P0SPZ1 A0A8P0SPZ1_CANLF Toll-like receptor 1 TLR1 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] DTYGKKEDPE;LDLSFNAFDDLP;MAQRTYLEWPKEKS;VQSEWCHYELYFAHHNLFHEGSNN 4 7.9 0.98654 -0.45876 0 8.98789 0 0 0 8.06134 0 9.52425 0 0 0 0 0 7.75261 0 A0A8P0SPZ8 A0A8P0SPZ8_CANLF Melanoregulin MREG Canis lupus familiaris (Dog) (Canis familiaris) melanosome transport [GO:0032402] melanosome [GO:0042470] LEHHSDGNPYSSFG;NIFPTSWELSE 2 12.3 0.99093 -0.18617 0 6.84875 0 0 0 0 0 0 0 0 9.42173 0 0 0 0 A0A8P0SQ05 A0A8P0SQ05_CANLF TSPY like 1 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] EDLWPNPLQYY;LREGVRRARRRPIREPVEI 2 8.8 0.9912 -0.18557 0 0 0 0 0 5.70752 0 0 0 0 0 8.37025 0 0 0 A0A8P0SQ07 A0A8P0SQ07_CANLF Pepsinogen B2 PGB2 PGB1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] LGYDTVTVQNIVI;TLGDVFLKEYYTI 2 6.7 0.99645 -0.10979 0 0 0 0 0 0 10.7065 0 12.3815 0 0 0 0 0 0 A0A8P0SQ19 A0A8P0SQ19_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DEADYYCQVWDSNHFI;YQQKLGQAPVL 2 27 0.99118 -0.27218 0 0 0 0 0 0 0 9.92949 0 0 0 0 0 0 0 A0A8P0SQ27 A0A8P0SQ27_CANLF Olfactory receptor family 4 subfamily D member 5 OR4D5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISQPLRYRIIM 1 3.5 0.98326 -0.2525 0 0 0 0 0 0 11.4385 0 0 0 0 0 0 0 0 A0A8P0SQ38 A0A8P0SQ38_CANLF Potassium calcium-activated channel subfamily N member 4 KCNN4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calmodulin binding [GO:0005516]; small conductance calcium-activated potassium channel activity [GO:0016286] GSGLKLRGWVVVKKKVKRR;KKVKRRPPQVLPLLLLHL;VVKKKVKR 3 6.5 1.003 -1.0067 0 0 7.10915 0 0 0 5.39204 0 0 3.63134 0 0 0 0 0 A0A8P0SQ48 A0A8P0SQ48_CANLF Meiosis specific with coiled-coil domain MEIOC Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321] AEGTCSSN;DVEKALQDIVNC;HLGSIHIV;MKESGVDTY 4 4.1 1.0032 -1.3825 0 0 8.33069 0 0 0 7.21267 0 7.14088 0 0 0 8.60984 0 8.724 A0A8P0SQ97 A0A8P0SQ97_CANLF STAGA complex 65 subunit gamma LOC475708 Canis lupus familiaris (Dog) (Canis familiaris) SAGA complex [GO:0000124] DSLMGSSPVFNQ;ISSSQTNRSSFDL 2 8 0.98598 -0.43542 0 0 12.1953 0 0 0 0 0 8.5297 11.9579 0 0 0 0 0 A0A8P0SQ98 A0A8P0SQ98_CANLF Olfactory receptor family 10 subfamily AB member 2 OR10AB2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TALRKVLGKTDRFIP 1 4.7 0.95184 0.053887 0 0 0 0 0 0 0 0 0 0 0 6.33342 0 0 0 A0A8P0SQA3 A0A8P0SQA3_CANLF Ribonuclease A-domain domain-containing protein RNASE12 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] nucleic acid binding [GO:0003676] DVKGLLPLMILMVIIF 1 9.5 0.9549 0.049233 0 0 0 0 0 0 0 0 0 0 0 4.54411 0 0 0 A0A8P0SQA9 A0A8P0SQA9_CANLF c-SKI SMAD4-binding domain-containing protein SKOR1 Canis lupus familiaris (Dog) (Canis familiaris) SMAD binding [GO:0046332] EQMELRKKLEREF;GEPKGGPGTGSGAGAGAGGG;GGGANGGAGA;GGGGGGGA;GGGGGGGG;QPSPANTDRGEDGLTLD;RTFSLQGGGGGGGGA 7 7.4 1.0014 -0.64206 0 0 7.84875 0 0 0 9.45325 0 11.3063 10.0761 0 0 0 0 9.54518 A0A8P0SQE5 A0A8P0SQE5_CANLF Klotho beta KLB Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" AEPLFKTGDYPPAMREYI;HNYNTNFRPYQ;ITILHKRKRRKIWKAKNLQ;KSSAYYYKQIIQ;LVAWHGYGTGMHAP;SETQRNTECMVC;SITILHKRKRRK;VLLSSITILHKRKRRKI 8 8.8 0.99066 -0.26858 10.1272 0 0 0 0 0 5.14967 0 0 9.10221 0 8.65682 0 10.4705 7.95757 A0A8P0SQG9 A0A8P0SQG9_CANLF Cadherin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] EEQPEFSLTLMALDGGSPPRSGTT;GVWAHNGEVRTARL;ILMVFLSQAR;VGSNGLQKYTISPNSH;VLTRNHSEGKKYPD;VPRTDLKKL;YGLFQASDEIKQ 7 12.4 1.0033 -1.5144 0 0 0 7.91217 9.40216 9.60844 10.3977 10.5512 0 0 0 0 0 0 11.3888 A0A8P0SQK0 A0A8P0SQK0_CANLF Osteoclast stimulatory transmembrane protein OCSTAMP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPLQAAWVAFSQP;LQEAQAMHLV;RLLHLSEPQFPRLHNN;WAARPKLSP 4 8.7 1.0018 -0.74423 0 0 3.21982 10.496 0 0 12.1181 0 0 0 0 0 0 0 0 A0A8P0SQK3 A0A8P0SQK3_CANLF Peptidase C19 ubiquitin carboxyl-terminal hydrolase domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579] cysteine-type deubiquitinase activity [GO:0004843] AYHCSKCLEKVP;EADPAEVGEASGE;LDQGRCLQERNRP;LVYVLYAVLV;SYVLSQKH;VGEASGESTRDPTVNL 6 13.4 1.0021 -1.0147 0 0 7.83851 0 8.9458 7.87823 0 0 0 4.64778 13.8063 0 0 11.4189 9.66558 A0A8P0SQK5 A0A8P0SQK5_CANLF Transcription factor SOX SOX4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" EAERLRLKHMADYPDYK;GAGGGGGG;GGGGGGGG;GGGGGGSG;PDYCTPEVSEMISGDWL;SSSALDRDLDFN;VGAGAGAG;VGGGGGGG;VGGGGGGGG 9 16.4 0.92247 0.11998 0 0 0 10.3158 0 0 10.8597 0 12.0678 8.45964 0 0 11.8353 0 0 A0A8P0SQL3 A0A8P0SQL3_CANLF G protein-coupled receptor 37 like 1 GPR37L1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AFLGCCCCCCGACGG;AYAIMLLALV;CCCCCCGACGGPDA;CCCCCCGACGGPDAPG;CCCCCCGACGGPDAPGG;CCCCCCGACGGPDAPGGGSDS;CCCGACGG;CCCGACGGP;GCCCCCCGAC;GCCCCCCGACGGPDA;GCCCCCCGACGGPDAPGG;GCCCCCCGACGGPDAPGGG;GCCCCCCGACGGPDAPGGGS;HLLSVGPLP;LGCCCCCCGACGGP;LGDVSCRAVPFMEVS;PLGRAFLGCCCCCCG;TLPENVCNIVVAYLSTELTRQ;VGSMILAVPE 19 16.1 0.99903 -3.0401 3.84177 10.1835 3.03235 6.08772 0 4.09331 9.26554 0 6.80038 0 6.01647 7.83226 0 8.53834 0 A0A8P0SQL9 A0A8P0SQL9_CANLF FGF1 intracellular binding protein FIBP Canis lupus familiaris (Dog) (Canis familiaris) FKVVEEMRGS;HSLDGFRHQALWDRYMGTLRGCLL;NWTLGAVDSQVDDMD 3 13.7 1.0021 -1.2023 0 10.1782 0 0 0 0 0 0 11.0458 0 0 0 0 0 0 A0A8P0SQM8 A0A8P0SQM8_CANLF Peptidyl-cysteine S-nitrosylase GAPDH Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; regulation of translation [GO:0006417] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; transferase activity [GO:0016740]" STFDAGAVLTLNTS 1 8.9 0.9931 -0.18758 0 0 0 0 0 0 0 0 0 0 0 0 0 8.54466 0 A0A8P0SQN5 A0A8P0SQN5_CANLF Retroelement silencing factor 1 RESF1 Canis lupus familiaris (Dog) (Canis familiaris) AGCIKTTDTPYNELAPNS;EHDDPLCE;EKPNMLEFKLCPDGLI;RKIKINKNLLMAAGCIK;SGLTYPDYRSL;VLTPKEYLQRQKHKE;YDKQEQNKNGDGT 7 5.5 1.0024 -1.1517 8.72264 0 0 0 0 0 10.3497 0 0 0 6.76341 0 10.711 0 0 A0A8P0SQQ6 A0A8P0SQQ6_CANLF Protein arginine methyltransferase 3 PRMT3 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] metal ion binding [GO:0046872]; protein-arginine N-methyltransferase activity [GO:0016274] DSGDEAAWEDDDEDEDEDG;LPELSDSG;NCHSRVVFSTGP 3 6.7 0.95278 0.04941 0 0 0 0 6.34168 0 0 0 0 0 0 3.40681 0 0 0 A0A8P0SQS1 A0A8P0SQS1_CANLF Rap guanine nucleotide exchange factor 3 RAPGEF3 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] PLTTSGSSTHSL;QEHSTYICNKRQQI;SQWVALYG;TVALRKPP;VLERASQGAGPSRPPTPGRNRYTVM;WKGSVNVVTHGKGL 6 9.9 0.99393 -0.17589 0 0 0 0 0 0 0 12.0357 0 0 0 0 0 0 0 A0A8P0SQT5 A0A8P0SQT5_CANLF Olfactory receptor OR5P6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GSVVFFGSSECFLLA 1 4.8 0.9821 -0.25078 8.17073 0 0 0 0 0 0 0 6.91564 0 0 0 0 0 0 A0A8P0SQT8 A0A8P0SQT8_CANLF T-cell receptor alpha chain constant domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTHLSVISDVQDPDPS;IGLRILLL;LVIGLRILLLKVIGFNL 3 21 0.9509 0.056486 0 0 0 7.33307 0 8.78911 0 0 0 6.99661 0 0 8.06507 0 0 A0A8P0SQT9 A0A8P0SQT9_CANLF MutS homolog 4 MSH4 Canis lupus familiaris (Dog) (Canis familiaris) meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298] ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983] MHFEVQHVKDT;MLLSFAHACTLSDYVR;NINEFLDIARRTYTE;NMRTQKCYAVRSNINE 4 5.7 0.87064 0.18784 4.96421 0 0 0 0 0 4.28481 10.0296 10.0362 0 0 0 0 0 0 A0A8P0SQU8 A0A8P0SQU8_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634] lipid binding [GO:0008289] FTDGAWVQHQEWDGKESTITRKLE 1 19.4 0.9935 -0.27978 0 0 0 0 0 0 0 13.0928 0 0 0 0 0 0 0 A0A8P0SQV2 A0A8P0SQV2_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVGEFEHALLAYT 1 3.1 0.94077 0.05986 0 0 0 0 10.5063 0 0 0 0 0 0 0 0 0 0 A0A8P0SQV7 A0A8P0SQV7_CANLF StAR related lipid transfer domain containing 4 STARD4 Canis lupus familiaris (Dog) (Canis familiaris) intracellular cholesterol transport [GO:0032367] cholesterol binding [GO:0015485] AADSHLPPPPAAAP;AAPTPAAPPTCCRS;AEPRPLSPHAAAPPP 3 7 0.98665 -0.42753 0 0 9.52221 0 0 0 0 0 0 8.33816 0 0 0 0 0 A0A8P0SQV8 A0A8P0SQV8_CANLF KIAA1614 KIAA1614 Canis lupus familiaris (Dog) (Canis familiaris) FPDGTTQLQLQRSPEG;GVDHAEGA;GVPPERPAGDVDWDSG;HRHEEAKHLLQRARMKARTRPL;LSEPGEPADTPL;LVVSCPLRQMFGNRG;NGHLPRPWSCSL;PESLETISASSL;PPSAAPSD;QNGHTSDSSSGESSSGRWPR;RGPPRSEPDLGRYG;SSSSLASTLG;VTPGQPGGP;WNGRSPWPPEAV 14 15.1 1.0016 -2.6314 0 10.8573 6.80954 7.96803 6.88777 10.08 0 6.41525 10.309 0 10.1295 10.2432 6.07884 0 8.31642 A0A8P0SQW5 A0A8P0SQW5_CANLF Interferon regulatory factor 2 binding protein 2 IRF2BP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AAGLGSAQPAELSSHKRPASV;EPALTAGRLLGFEANG;PPGAAAPA 3 7.6 0.99441 -0.15618 0 0 0 0 0 0 0 6.18194 0 0 0 0 0 0 0 A0A8P0SQX0 A0A8P0SQX0_CANLF Transmembrane 4 L six family member 4 TM4SF4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CCGCCGNESC;CGDCQCCGCCGGDG;CGDCQCCGCCGGDGP;GLKNNDCCGCCGNESCGK;GTLCGDCQCCGCCGGDG;LCGDCQCCGCCGGD;LCGDCQCCGCCGGDG;LGTLCGDCQCCGC;LGTLCGDCQCCGCCG;LLGTLCGDCQCCGCCGGDG;NDCCGCCGNE;NNDCCGCCGNE;NNDCCGCCGNESCG;TLCGDCQCCGCC;TLCGDCQCCGCCGG 15 20.4 0.98978 -0.52877 9.29944 0 5.96067 6.92588 4.7543 6.88984 0 7.50176 7.87418 5.36156 6.06011 0 0 0 7.79038 A0A8P0SQZ3 A0A8P0SQZ3_CANLF PRKR interacting protein 1 PRKRIP1 Canis lupus familiaris (Dog) (Canis familiaris) double-stranded RNA binding [GO:0003725] AKRRKKRQKLKEKKLLAK;KKLLAKKMKLEQ;MKNPDKAVPIPEKMS;NPDKAVPIPEKMSEWAP;TAKRRKKRQKLKEKKLLAKKMKL 5 23.7 0.98428 -0.23983 0 0 0 0 6.93687 0 0 0 0 4.1254 8.69335 0 0 12.7935 9.74572 A0A8P0SQZ6 A0A8P0SQZ6_CANLF RRM domain-containing protein RALYL Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] TDDDYDGHGYDIC;VGCSVHKGYAFVQ 2 17.3 0.88142 0.13293 0 0 0 0 0 5.8188 0 0 0 0 0 0 0 4.62825 0 A0A8P0SR06 A0A8P0SR06_CANLF Nanos homolog 1 NANOS1 Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723]; zinc ion binding [GO:0008270] FGGEGGGG;SSCCSPDGDEPGSRGRY 2 9.3 0.9772 0.046227 0 0 0 2.25142 0 0 0 0 5.35223 0 0 0 0 0 0 A0A8P0SR17 A0A8P0SR17_CANLF Phosphoinositide phospholipase C (EC 3.1.4.11) PLCD1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042] calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435] GVGRDMASRQTAVVTNNGFNP;KILLKGKKLGGLLPPG;LKGKILLKGKKLG;LKGKILLKGKKLGGLLPPG 4 5.1 0.80769 0.208 0 10.6949 0 0 0 0 0 0 0 6.88387 4.02334 0 4.70238 0 0 A0A8P0SR27 A0A8P0SR27_CANLF Chloride channel protein CLCN3 Canis lupus familiaris (Dog) (Canis familiaris) early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886] voltage-gated chloride channel activity [GO:0005247] EQCCWGSNETTFEE;LDAKEEFTHTT;LSAASAAG 3 4.4 1.0029 -1.0081 0 4.28518 0 0 0 0 0 0 0 0 0 0 0 8.34052 13.3809 A0A8P0SR56 A0A8P0SR56_CANLF Sp2 transcription factor SP2 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] DELQRHARTHTGD;EGGWAAGS;KPSQNFQIQAA;LSPTQIQLQMEQALAGEAQ 4 8.2 1.0033 -1.5625 8.3067 8.69662 0 0 0 8.03936 0 10.4819 0 0 0 0 0 0 10.5032 A0A8P0SR57 A0A8P0SR57_CANLF Zinc finger protein 461 ZNF461 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ASGLVMFKDVAIDVSQ 1 3 0.96297 0.049233 0 0 5.91967 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SR61 A0A8P0SR61_CANLF Ribosomal protein L23/L25 N-terminal domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribosomal subunit [GO:0044391] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] AKAKALKAKKVVLKGI;EALAPPKAEAKAKALKAKKVVLK 2 20.2 0.92688 0.095486 0 0 3.09038 0 0 5.81417 0 0 0 0 0 0 0 0 0 A0A8P0SR62 A0A8P0SR62_CANLF C-type lectin domain-containing protein LOC611536 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] STEAELNFIIQ;WALNDFPCNFETRRICKLPGTAFN 2 16.6 0.98261 -0.25004 0 0 0 0 8.97499 8.94565 0 0 10.9117 0 0 0 0 0 0 A0A8P0SR83 A0A8P0SR83_CANLF Chromosome 17 C1orf162 homolog C17H1orf162 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RLGLRSRLVVKSRIQQ 1 4.7 0.96034 0.049233 0 8.19899 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SRA1 A0A8P0SRA1_CANLF C3H1-type domain-containing protein MKRN1 Canis lupus familiaris (Dog) (Canis familiaris) protein polyubiquitination [GO:0000209] metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630] FQRGYCIYGDRCSLALRPMRRTW;GAAAAAAAASPTPIPTV;GAGGGGGG;GGGGGGGG;VALGFSPTATTLTVS;VTSPSSGAGGGGGGGGGGGGGG 6 43.8 0.98681 -0.49966 0 0 0 0 0 12.5407 0 0 0 0 0 0 0 0 10.4246 A0A8P0SRB0 A0A8P0SRB0_CANLF GLI family zinc finger 4 GLI4 Canis lupus familiaris (Dog) (Canis familiaris) LPCSQRHPGCWPG;PFACGACG;PWCTTLRAPGASGMAGEPARAA;RPKCGDRFGQEASLERPAGHQPPGP 4 7.5 1.003 -1.6576 0 0 0 8.09408 0 7.78692 0 0 0 0 0 0 0 8.8106 0 A0A8P0SRB4 A0A8P0SRB4_CANLF Coronin CORO1B Canis lupus familiaris (Dog) (Canis familiaris) stress fiber [GO:0001725] AEELYRLDSLH;DLIYNVSWNR;RKLDEVMQELRA;RQLALWDPENLEEPMALQ 4 10.4 0.94224 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 6.27068 0 A0A8P0SRC5 A0A8P0SRC5_CANLF Retinal G protein coupled receptor RGR Canis lupus familiaris (Dog) (Canis familiaris) phototransduction [GO:0007602]; visual perception [GO:0007601] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881] EFLPPPAS;VLQEGCLTIPDSTPG 2 5.9 1.0048 -1.0505 0 0 7.80632 0 0 0 10.7201 0 0 0 0 0 0 0 0 A0A8P0SRC7 A0A8P0SRC7_CANLF Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC 1.1.1.8) GPD1L Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; NADH oxidation [GO:0006116] glycerol-3-phosphate dehydrogenase (FAD) complex [GO:0009331] "NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein homodimerization activity [GO:0042803]" TIEELEKEMLNGQKLQGP 1 5.5 0.94799 0.05532 0 0 0 0 9.63094 0 0 0 0 0 0 0 0 0 0 A0A8P0SRD0 A0A8P0SRD0_CANLF Cyclic nucleotide gated channel subunit beta 3 CNGB3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] EPQTSFEIVFQL;ESHAKMQDKISEKNSLRDL;IKQGEVQVLGGSDG;IPKNVQNRVRTWYEYTWDSQRM;LNFFSGVFVFSSLIGQMQ 5 11.1 1.0022 -0.6642 0 9.65431 9.73378 0 10.0884 0 0 0 9.20499 0 0 0 0 0 0 A0A8P0SRG4 A0A8P0SRG4_CANLF Leucine rich repeat and Ig domain containing 2 LINGO2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLRVLNVSQNLL;HSTALSFYFTCKK;ISLHLKHL;VLSINNNPLACDCRL 4 7.9 1.001 -0.63075 0 9.27559 0 0 0 0 0 0 8.69902 0 0 8.77992 0 0 0 A0A8P0SRH9 A0A8P0SRH9_CANLF 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Esterase OVCA2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1) DPH1 Canis lupus familiaris (Dog) (Canis familiaris) protein histidyl modification to diphthamide [GO:0017183] 2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560] EPCLPPEEQ;FLWIWLPWKQCCCPRCG;SIDWGTAFPKPLLTP 3 6.7 0.99202 -0.29172 0 0 4.50487 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SRJ3 A0A8P0SRJ3_CANLF Proteasome subunit alpha type-1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] "nucleus [GO:0005634]; proteasome core complex, alpha-subunit complex [GO:0019773]" GARFQSAPTYLE 1 4.6 0.94436 0.05044 0 0 9.1575 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SRL2 A0A8P0SRL2_CANLF Solute carrier family 25 member 48 SLC25A48 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020] KPRAVALGK;KPRAVALGKQPVYQGPV 2 6 1.0025 -0.75799 0 0 0 0 3.96523 0 0 0 0 0 0 0 5.45204 0 0 A0A8P0SRM8 A0A8P0SRM8_CANLF "NRDE-2, necessary for RNA interference, domain containing" NRDE2 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] nucleus [GO:0005634] ALNGGETFRTDKKPDPA;DDEDDEPEDE;EMQEILDLMTEK;FAIEAEKMRKTLVESVQ;KEKKRKRKHHHKKIKR;KQTSRKKKKEKKRKRKH;QEKRKRSLKLVLEK;RKKKKEKKRKRKHHH;RKRKHHHKKIKRKH;SSSGSEPD 10 8.9 0.79902 0.2101 0 0 0 8.80874 4.59288 0 0 0 0 0 0 0 6.46079 0 0 A0A8P0SRN3 A0A8P0SRN3_CANLF Zinc finger protein 37 homolog LOC481675 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DPRMSISSGPWWCRLGPKS;VSFKDVTVDFTWEEWQQLDCAQRN 2 8.1 0.98545 -0.23668 0 12.4773 0 0 0 0 0 0 0 0 0 0 0 8.59529 0 A0A8P0SRQ7 A0A8P0SRQ7_CANLF Neuropeptide Y receptor type 5 (NPY-Y5 receptor) NPY5R Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] neuropeptide Y receptor activity [GO:0004983] DQWMFGRVMCH;ICHLLGMMSCCLNPILYGF;LPVFHSLVELQETFDSAL 3 10.8 0.9813 0.035491 0 0 7.69815 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SRQ9 A0A8P0SRQ9_CANLF Immunoglobulin like domain containing receptor 1 ILDR1 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] CCPQYCCCYIRCPCCPA;CWCQCCPQYCCCYIRCP;EVRIVAQRRGQNE;GVCWCQCCPQYC;GVCWCQCCPQYCC;GVCWCQCCPQYCCC;GVCWCQCCPQYCCCYIRC;IFIILGALLLLLLI;LTVIFIILGALLLLLLI;PLLQRDLSLRSSLP;PRGDAQRPRRRRHRSY;VHRELQGREPKRL;WCQCCPQYCCCYIRCPCC 13 18.6 0.84449 0.19435 6.66477 7.34359 0 0 0 3.94944 3.87696 12.9468 0 0 10.4055 9.85156 6.52921 12.073 0 A0A8P0SRS8 A0A8P0SRS8_CANLF EF-hand calcium binding domain 2 EFCAB2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CAAAAPGG;EEGEPFSQEEMEEML;GGKDAATQ 3 9.9 1.003 -2.1549 0 0 12.3151 0 9.19906 0 0 7.41701 0 0 3.20744 0 0 0 0 A0A8P0SRT8 A0A8P0SRT8_CANLF Ras-related protein Rab-4B RAB4B Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] GTP binding [GO:0005525]; GTPase activity [GO:0003924] QPRSAQAVAPQPCGC 1 8.1 0.951 0.053888 0 7.20271 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SRV0 A0A8P0SRV0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) TP53RK Canis lupus familiaris (Dog) (Canis familiaris) tRNA processing [GO:0008033] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LEKAFLSTH;SAPVVFFVDY 2 6.3 0.98949 -0.50866 0 0 0 0 0 0 0 0 0 0 0 10.4635 0 0 0 A0A8P0SRY9 A0A8P0SRY9_CANLF RNA polymerase I subunit E POLR1E Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleolus [GO:0005730] DNA binding [GO:0003677] TISGLEPSN;VGSESLNCAVAKAAE;YEALQSPSEAFR 3 6.9 0.98579 -0.44999 0 0 0 0 0 0 0 0 9.68505 0 8.87587 0 0 0 0 A0A8P0SRZ0 A0A8P0SRZ0_CANLF Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) PROC Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] CCGHGSCID;CDCGRGWEGRF;CIDGIGAFHCDCGRGWEG;EIFQNVDDTLAYWSK;HCDCGRGWEGRFCQHVKFPC;IVPICLPDS;PCCGHGSCIDGIGAFHCDCG 7 14.4 0.97255 0.048206 0 0 0 0 0 7.58135 0 0 0 0 0 0 0 0 0 A0A8P0SS12 A0A8P0SS12_CANLF Integrin subunit alpha 6 ITGA6 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] GAPQYFDRDGE;LVRASIDVAATACGFFKR;NKDGWQDI;NRTGGLYSCDITSPG;QGPGGKVV 5 6.2 1.0032 -2.0666 0 0 8.77788 0 0 0 12.0054 0 0 7.85119 0 0 0 0 10.2952 A0A8P0SS13 A0A8P0SS13_CANLF "Testis, prostate and placenta expressed" SPMIP8 TEPP Canis lupus familiaris (Dog) (Canis familiaris) NRYREGKLVPIAP 1 4.9 0.93818 0.059561 0 0 0 0 0 7.41591 0 0 0 0 0 0 0 0 0 A0A8P0SS32 A0A8P0SS32_CANLF Nebulin related anchoring protein NRAP Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] actin binding [GO:0003779] AGGYDFRLD;EDERHRYTMTLGLPE;EILHVKRRKALP;ESKYRQHPQ;NELASDVRYHQQ;NQITNERL;YRSDLNFMRGVPC 7 4.9 1.0031 -1.9571 5.11203 8.63379 10.9987 8.86824 0 9.55968 8.82372 8.12861 0 0 10.1243 0 7.48671 0 0 A0A8P0SS63 A0A8P0SS63_CANLF C-type lectin domain-containing protein MBL1 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; complement activation, lectin pathway [GO:0001867]" collagen trimer [GO:0005581]; extracellular space [GO:0005615] D-mannose binding [GO:0005537] DPARRRNKSRQLDRFRTMFLSS;GEPGQGLRGLQGPPGKVGPPGN 2 16.1 0.9908 -0.51494 0 0 11.6348 0 0 0 0 0 0 0 7.41083 0 4.81204 0 8.25148 A0A8P0SS73 A0A8P0SS73_CANLF C2H2-type domain-containing protein LOC102153308 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] QVIIKRKKIS;RELIMERLKKDESWDSRLMEAWQ;VTVKDEEMD 3 9.2 1.004 -0.82793 0 0 0 0 8.56323 0 0 0 0 0 0 0 0 0 0 A0A8P0SS84 A0A8P0SS84_CANLF Elastin (Tropoelastin) ELN Canis lupus familiaris (Dog) (Canis familiaris) collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576] extracellular matrix structural constituent [GO:0005201] AAAKAAKFGAGGAGVL;AAQFGLGG;FAGIPGVGPF;GVAGAAGKAGYPTGTGVGTQAAA;PYGGALGALGYQGG;VGVLPGVP;VPGVGGPGIVGG;YGVGVGAG 8 13 1.003 -2.5473 8.64721 10.802 0 9.66265 0 0 0 0 10.7398 11.0256 0 10.1537 11.2663 0 8.72212 A0A8P0SSC7 A0A8P0SSC7_CANLF Arylsulfatase family member J ARSJ Canis lupus familiaris (Dog) (Canis familiaris) sulfuric ester hydrolase activity [GO:0008484] DIQLDGYDVWETISEGLR;IIIYSSDNGGQP 2 5 0.98409 -0.24434 0 0 0 0 0 0 0 13.6767 0 0 0 0 0 0 0 A0A8P0SSD5 A0A8P0SSD5_CANLF Transient receptor potential cation channel subfamily M member 5 TRPM5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] ALVSNKPE;DLSRRSENPWRD;FCWEDIVHWT;GSPSCPNLYANWLV;IVERMMKDVFFFL;LCAFLCPALIY;PEPLDQKMVTWE;QEGSEELDTVI;VAYGVTTQ 9 8.2 1.0022 -1.3718 11.7005 11.5257 10.582 0 13.9036 10.2548 11.9154 11.5404 12.2607 11.0617 10.7858 10.7351 11.1706 11.3155 11.0682 A0A8P0SSF4 A0A8P0SSF4_CANLF Myocardin related transcription factor B MRTFB Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] EAFLDGTLPSTNEI;ITSGWSTM;LPVDSSVKEAI;PVRKPGPLP;QAEQQSIVPQFYVSS;SLELDAAEKDRK;TDQPPTRS;VGKEDYPQTQ 8 7.4 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.93558 A0A8P0SSG4 A0A8P0SSG4_CANLF Kinesin-like protein KIF19 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; microtubule [GO:0005874] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] SSPLTVHSNPAGIS;YTMLGTDHEPGI 2 2.6 0.98901 -0.19791 0 0 0 0 0 9.06614 0 0 0 0 0 0 8.64497 0 0 A0A8P0SSH0 A0A8P0SSH0_CANLF Dual specificity phosphatase 22 DUSP22 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] HEVHQFRQWLKEEYGE 1 7.3 0.96287 0.049233 0 0 0 0 0 0 5.59317 0 0 0 0 0 0 0 0 A0A8P0SSJ7 A0A8P0SSJ7_CANLF Copper homeostasis protein cutC homolog CUTC Canis lupus familiaris (Dog) (Canis familiaris) ADGLVFGALTED 1 4.9 0.94282 0.05044 0 0 11.1562 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SSJ8 A0A8P0SSJ8_CANLF Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] LEDPVHAVVY 1 2.2 0.99811 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4556 A0A8P0SSK5 A0A8P0SSK5_CANLF V-set and immunoglobulin domain containing 4 VSIG4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of interleukin-2 production [GO:0032703]; negative regulation of macrophage activation [GO:0043031]; negative regulation of T cell proliferation [GO:0042130] membrane [GO:0016020] EYQIITQINSDYTHLLHTVSPD 1 7.2 0.97412 0.046883 0 0 0 9.50253 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SSM2 A0A8P0SSM2_CANLF Eukaryotic translation initiation factor 4E family member 2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743] LQYNYTFWYSRIAP 1 5.3 0.99074 -0.26821 0 0 0 0 0 0 0 0 0 0 0 9.63981 0 0 0 A0A8P0SSM8 A0A8P0SSM8_CANLF Pentatricopeptide repeat domain 1 PTCD1 Canis lupus familiaris (Dog) (Canis familiaris) DRYKEKNTYLEKIDGFRAYYKQW;FGTLSSKYSSRRMFR;LGAVPPAV;LGDPEVASAL;MVTLTSLASEPSRWGLE;QTFCNLAIGCRR;SALKLRQQLQARN 7 15 1.0035 -2.0854 3.71787 0 9.46181 0 7.42635 0 10.5396 0 13.4378 9.00501 0 9.07663 12.3376 9.169 10.8274 A0A8P0SSN1 A0A8P0SSN1_CANLF Vestigial like family member 2 VGLL2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] FPKLPKILPPHL;LDVMYQVYGPP;SFWNSAYQAPVPAP;SPAALHSHLHQ 4 13.7 0.99341 -0.15181 10.5284 0 0 0 0 0 9.85798 4.54436 0 10.7052 0 0 0 0 0 A0A8P0SSP3 A0A8P0SSP3_CANLF Transcription initiation factor TFIID subunit 12 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352] SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982] ERQRNMWIPGFGSE 1 6.7 0.93737 0.062581 0 0 0 8.23295 0 0 0 0 0 0 0 0 10.0286 0 0 A0A8P0SSQ3 A0A8P0SSQ3_CANLF Regulator of G protein signaling 19 RGS19 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] APPAAPSRNPCCLCWCCCCSCS;CCCCSCSWNEER;CCLCWCCCCSC;CWCCCCSCSWNE;GGGGGGGG;NEERRRAWRASR;NPCCLCWCCC;PCCLCWCCCCSCSW;QHVVDEKA;WCCCCSCSWNEER 10 8.5 1.0041 -1.0854 0 0 0 4.84519 0 0 4.27015 7.57471 7.35288 0 13.0109 4.24648 0 0 10.0984 A0A8P0SSR3 A0A8P0SSR3_CANLF MANSC domain containing 1 MANSC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LRLSSSQNCPTKSLEDVVIDIQ;MFFREEWSLTYTFVIIC;PMDWKSPPETVTFREIS;VGTLLFGVLFLAI 4 15.9 0.82339 0.20351 0 0 0 0 0 9.32141 10.6262 0 0 0 0 0 5.7429 8.53737 0 A0A8P0SSR4 A0A8P0SSR4_CANLF Pleckstrin homology and RhoGEF domain containing G2 PLEKHG2 Canis lupus familiaris (Dog) (Canis familiaris) guanyl-nucleotide exchange factor activity [GO:0005085] ACGGHLSH;ALAQPQLSP;EIRSAWQALEQGQLARPGFPEPL;EPLPGPPIRLHLSPVG;KPVQRILK;LGIQVPAAAPLP;LNHPTLLAP;QVPATTPLP;SSEEEEEEELEMD 9 7.9 0.99717 -3.6283 0 11.3542 9.92564 4.17536 11.6002 7.52513 10.9192 0 0 0 0 4.9743 9.09048 0 4.88093 A0A8P0SSR6 A0A8P0SSR6_CANLF Transcription factor 23 TCF23 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] ETSWSNQRWSR;SRLSRTRQDRW 2 10.3 0.98942 -0.2188 0 0 0 0 0 10.9367 0 0 0 0 0 0 0 0 6.49771 A0A8P0SSS0 A0A8P0SSS0_CANLF Metalloprotease TIKI (EC 3.4.-.-) (TRAB domain-containing protein 2) TRABD2A Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] LNQTLLQQESLRAGSLQI;VIFSHDSSQVPNF 2 6.1 0.99441 -0.12784 0 0 0 0 0 0 0 9.94011 0 0 0 13.6607 0 0 0 A0A8P0SSU7 A0A8P0SSU7_CANLF FLYWCH family member 2 FLYWCH2 Canis lupus familiaris (Dog) (Canis familiaris) VPGPATLAKALLK 1 8.6 0.94105 0.059561 0 0 0 0 0 0 0 0 0 3.77852 0 0 0 0 0 A0A8P0SSW0 A0A8P0SSW0_CANLF "ATP synthase subunit d, mitochondrial" Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [GO:0000276]" proton transmembrane transporter activity [GO:0015078] LVDDYEKKFN 1 10.4 0.99964 -0.61146 0 0 0 0 0 0 0 0 0 0 8.22497 0 0 0 0 A0A8P0SSX3 A0A8P0SSX3_CANLF Dynein axonemal heavy chain 12 DNAH12 Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] axoneme [GO:0005930]; dynein complex [GO:0030286]; microtubule [GO:0005874] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569] DGVYIHGLYLD;DLREYDKDNI;DRLINDDDRYWLFKLIK;FGVCFFHALVQERKKFG;GAFYLNLGGAPEGPA;GVIAYLGA;GVSHDTDFQWLAQL;IFIDDMNMPAL;LDKIMKGLN;RYEESMNTVLVQEMERFNNLIKTIR;SLIWSIGGSCDTD;SLTRLFEVLLCN;SQVGEMKMELVQ;TVSRCGMI;VEKYNWLLDGTAV;YNPLIIENPHYKF 16 5.3 1.004 -1.9772 5.95494 0 0 0 0 8.8568 12.0046 8.28813 8.87781 0 0 0 7.90779 10.9181 6.16575 A0A8P0SSY3 A0A8P0SSY3_CANLF Doublecortin DCX Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] GVKPRKAVRVLLNKKTA;IVYAVSSDRFRSFDA 2 10 0.9372 0.10014 0 0 0 10.0083 0 0 0 0 5.57468 0 0 0 0 0 0 A0A8P0SSY5 A0A8P0SSY5_CANLF Divergent protein kinase domain 2A DIPK2A Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] AAAPAPSQTAGSPWLPPQQ;PESEGGELGGGSSR;REGGRRRVVLKRLGS;SGEPARTNPGVRR 4 6 0.98749 -0.34895 6.01598 0 10.5834 0 0 0 0 0 0 0 0 0 0 0 12.3553 A0A8P0SSZ5 A0A8P0SSZ5_CANLF Phosphodiesterase (EC 3.1.4.-) PDE1B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytosol [GO:0005829] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" DETRQILDTEDE;SPTCSTPSAP;VGPTYSTV;VLNCLKNLDRWCFDV 4 8 1 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.75403 A0A8P0SSZ7 A0A8P0SSZ7_CANLF RNA helicase (EC 3.6.4.13) MOV10L1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] helicase activity [GO:0004386] IDILTFQPLLAE;QVYYALLDSRILV;SLQNPAPP;VTSLLEGAGY 4 3.7 1.0031 -1.9195 0 0 0 0 0 0 0 0 0 6.25369 0 0 0 0 9.39019 A0A8P0ST04 A0A8P0ST04_CANLF Fibronectin type-III domain-containing protein LOC100686341 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] LVLLSSVCCREPQP;SEWSPTVLFGLPEER;SLHEDEVECPHY;STFRARVRYVYNDLWSEWSPTVL;VGCHFDQLGEPQNM;WNYIRNVSEQE 6 20.1 0.99424 -0.55839 0 0 0 9.86912 10.5994 9.29421 0 10.4162 0 0 4.48543 0 9.3175 0 9.67414 A0A8P0ST06 A0A8P0ST06_CANLF Trans-golgi network protein 2 TGOLN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEEKPKPQATGDGTSKVKSQMQ;IELTEDVEPKKA;LNDYKNESEERV;PADKDPTLND 4 12 0.98745 -0.36943 0 0 0 0 0 0 10.4529 0 0 0 0 13.5915 0 7.49721 10.8592 A0A8P0ST11 A0A8P0ST11_CANLF Zinc finger protein 318 ZNF318 Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] ASRWPMYPASQPS;DKLKGSYAIRPEERSRE;DVQGKMIYEL;IDSFPSEARSLLQNPQDVP;ISDEKNRASQ;LETERRRQSELKRK;PIAAYEYYDA;PVYSGHPSLPLSGA;WLENSAPE;YISREEGPLSPFL 10 5.7 1.0034 -2.2102 0 0 0 10.2923 0 9.22571 0 0 0 0 10.4017 0 11.4376 10.8955 0 A0A8P0ST17 A0A8P0ST17_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRZ1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] AGLVGGGDDGDSDDYDNDDDDRE;EPGAWAVVAGDEES;GDDGDSDDYDNDDD;GDDGDSDDYDNDDDD;GDGDGDGD;IGWSYTGALNQKNWGK;REFLTDGYQ;STLTSELVYPHELLTSTEG;TLTSELVYPHELLTSTE;VGGGDDGDSDDYDNDDD;VSRATEKSFE 11 5.2 0.80615 0.20712 0 0 7.68916 0 0 0 0 5.87978 0 0 0 0 0 0 10.0902 A0A8P0ST25 A0A8P0ST25_CANLF F-box and leucine rich repeat protein 7 FBXL7 Canis lupus familiaris (Dog) (Canis familiaris) ALSCAPGA;NVQDCDVSVEALRFVKRHCRRCVI 2 7.2 0.98925 -0.50832 0 0 0 9.1694 0 10.2437 0 0 0 0 0 0 0 0 0 A0A8P0ST30 A0A8P0ST30_CANLF Sodium/potassium-transporting ATPase subunit alpha ATP12A Canis lupus familiaris (Dog) (Canis familiaris) proton transmembrane transport [GO:1902600] plasma membrane [GO:0005886] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium transmembrane transporter activity [GO:0008556] DEVRKLFIRLYPGSW;ETYTFDVDAMNFPTS;STNKFQLSIHKTDDP;TLGSTSIICSDKT 4 6 0.98745 -0.40555 0 0 0 0 0 0 0 0 7.4165 9.45063 0 0 0 10.3403 0 A0A8P0ST33 A0A8P0ST33_CANLF Fucose-1-phosphate guanylyltransferase FPGT Canis lupus familiaris (Dog) (Canis familiaris) "nucleotide binding [GO:0000166]; transferase activity, transferring phosphorus-containing groups [GO:0016772]" DTPSLKLDSEYV;IFSGIPKCHGNTSCVIQ;SEKLKRKEL;VLPAYSFVCSLSL 4 8.5 0.99569 -0.5652 7.93805 0 0 9.41043 0 8.36842 10.7912 0 0 0 0 0 10.0186 10.9661 0 A0A8P0ST43 A0A8P0ST43_CANLF Solute carrier family 25 member 32 SLC25A32 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020] nucleotide transmembrane transporter activity [GO:0015215] PACCITFVVYENV 1 4.1 0.94279 0.059681 0 0 0 0 0 0 5.68672 0 0 0 0 0 0 0 0 A0A8P0ST50 A0A8P0ST50_CANLF EGF-like domain-containing protein EREG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] growth factor activity [GO:0008083] ALTVILIILFLIIV;VQQPLSKEYVALTVI 2 15 0.91791 0.11467 0 0 0 3.71149 0 0 0 0 0 0 0 0 0 0 4.28895 A0A8P0ST64 A0A8P0ST64_CANLF A disintegrin and metallopeptidase domain 3-like LOC607729 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] CGSGPCCD;CGSGPCCDRK;DIYNCYCPGSTCIM;FAAGIALY;FSSCSMDDFKHMV;LLQNVSYGIEPLESAAAYEHMLY;VLLKRVLKI 7 10.7 1.0035 -2.2483 9.27936 9.10444 10.7412 7.70922 0 9.6341 9.87427 10.653 8.32026 0 10.6277 8.31356 9.02652 14.8111 10.2335 A0A8P0ST75 A0A8P0ST75_CANLF High mobility group box 4 HMGB4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] KARYQEEMMN;SWNKFKEQQPNTYLGFK;VGKKKKRRKRDPQAPRRPP 3 20.2 0.97746 0.046227 0 0 0 0 0 0 0 0 0 0 8.47642 0 0 0 0 A0A8P0ST80 A0A8P0ST80_CANLF Sperm associated antigen 16 Canis lupus familiaris (Dog) (Canis familiaris) DILVTCGEDRLW;GLDLAAAGDTAE;KGNCILTFEG;TGSADKSLSIWDARTGNCE;VLHTGFGHT 5 10.9 1.003 -0.98511 0 0 0 0 0 0 0 10.0932 8.96154 0 0 0 0 0 0 A0A8P0ST89 A0A8P0ST89_CANLF Small acidic protein C21H11orf58 Canis lupus familiaris (Dog) (Canis familiaris) DHDGEGDVAGDDDDDD;DHDGEGDVAGDDDDDDDS;EGDVAGDDDDDDDSPDPESPD;GDVAGDDDDDDDSPDPESPDDSESD;VVEDHDGEGDVAGDDDDDDDSPDPE 5 18.2 0.97507 0.035538 0 0 0 0 0 0 0 0 0 8.59943 0 8.03496 0 0 0 A0A8P0ST90 A0A8P0ST90_CANLF tRNA methyltransferase 10 homolog C (EC 2.1.1.218) (EC 2.1.1.221) (Mitochondrial ribonuclease P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (mRNA methyladenosine-N(1)-methyltransferase) (tRNA (adenine(9)-N(1))-methyltransferase) (tRNA (guanine(9)-N(1))-methyltransferase) TRMT10C Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; tRNA processing [GO:0008033] mitochondrion [GO:0005739] methyltransferase activity [GO:0008168] KRSKTFNSFPKDSLKI 1 3.8 0.99108 -0.27219 0 0 0 0 0 0 9.23048 0 0 0 0 0 0 0 0 A0A8P0ST92 A0A8P0ST92_CANLF Malic enzyme ME1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]" TSKAECTAEQCY;VGLACQQYSLAFR 2 4.6 0.9964 -0.58563 0 0 0 0 0 0 0 0 0 0 0 0 12.8579 0 0 A0A8P0STB1 A0A8P0STB1_CANLF ZFP2 zinc finger protein ZFP2 Canis lupus familiaris (Dog) (Canis familiaris) DIQQSTPVGQRF 1 2.6 0.9414 0.05044 9.40697 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0STC1 A0A8P0STC1_CANLF Selenoprotein O Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779] DFFSVVVSEMAQL;EITQSQLEELSIPQV;GPKAGAKP;IDYGPFGFMEAYNPD 4 14.4 0.98732 -0.3373 0 0 0 10.0434 0 0 10.8895 0 0 0 0 0 0 11.4118 0 A0A8P0STD6 A0A8P0STD6_CANLF PDZ domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TSETVVTITIRPAFIFE 1 5.7 0.97867 0.046227 0 0 0 0 6.96694 0 0 0 0 0 0 0 0 0 0 A0A8P0STE2 A0A8P0STE2_CANLF Geminin coiled-coil domain containing GMNC Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] PNSCSWEE;SWEEAQLSSQLYRNK;TETWVSFWAAGLLDDREPQ 3 11.9 0.98745 -0.40564 0 0 9.38621 0 7.45845 0 0 0 0 0 0 0 0 7.21442 0 A0A8P0STE6 A0A8P0STE6_CANLF Ankyrin repeat domain 12 ANKRD12 Canis lupus familiaris (Dog) (Canis familiaris) DKEGKTLKKHKL;PESSSVKSCKH;VKDEDHSPTFENSDC 3 2 0.98665 -0.23126 0 0 0 0 0 0 0 0 0 0 0 0 7.67878 8.58523 0 A0A8P0STF8 A0A8P0STF8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of macrophage activation [GO:0043031]; regulation of immune response [GO:0050776] membrane [GO:0016020] cell-cell adhesion mediator activity [GO:0098632] ISLFPSQVLINPPEE;IYSAVGKPIPQISL;LTVYMDHPLR;SLWVNVFH;VQVTWQKIQGSLTQNIGTYSSI 5 21.4 1.0025 -1.7935 7.52223 0 0 0 0 0 9.01865 11.634 0 6.12427 0 0 0 8.91934 0 A0A8P0STK8 A0A8P0STK8_CANLF Phospholipase A2 activating protein PLAA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DINAEQLPGREH;DPWLTAYNFLQ;LNAVQLAK;RRWQITGECL;SNFVSCVCIIPS;TAYNFLQKNDLNPMFL 6 8.4 1.0018 -1.4705 0 0 0 8.18344 0 0 9.31252 0 0 9.38939 0 0 0 0 10.3729 A0A8P0STM0 A0A8P0STM0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KTILALLLLLLLL;LLLLLLLL;RKPFFSHFKRK 3 12.8 0.98962 -0.19925 0 0 0 0 0 0 10.5398 0 10.3223 0 0 0 0 0 5.29752 A0A8P0STM7 A0A8P0STM7_CANLF RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) RITA1 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168] cytoplasm [GO:0005737]; nucleus [GO:0005634] tubulin binding [GO:0015631] SPAGTRPTPPDFDPPWVEKAN 1 7.7 0.98606 -0.24592 0 0 0 0 0 0 11.1846 0 0 0 0 0 0 0 0 A0A8P0STM8 A0A8P0STM8_CANLF Calsyntenin 2 CLSTN2 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; postsynaptic membrane [GO:0045211] calcium ion binding [GO:0005509] GAVSSIQITTELQ;PIDCELQK;SEEEEEEEGMGK;VEEDMSSSSSDSEDSEEEE;VEFPVVTLYMDGA 5 6.3 0.99572 -0.016525 10.3936 0 0 0 0 0 0 0 0 9.87446 0 0 0 9.8598 11.3269 A0A8P0STQ1 A0A8P0STQ1_CANLF Large ribosomal subunit protein uL4 (60S ribosomal protein L4) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] GVLGKKPTVGKKGKKTVGVKKPK;KEAVLLLKKLK;PEIQRALRAPRKKIHRRVLKKNPL;VGKKGKKTVGVKKPKKPV;VGKKGKKTVGVKKPKKPVVGKK;VGKKGKKTVGVKKPKKPVVGKKAAA;VHTNLRKSNR;VLKKNPLKNLRIMLKLNP 8 21.1 0.94298 0.060076 6.07275 0 7.76374 0 0 10.1857 8.29783 0 0 0 0 5.13939 0 0 0 A0A8P0STQ2 A0A8P0STQ2_CANLF 40S ribosomal protein S17 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VRGSSIKLQEEERESRDNCAPK 1 16.5 0.95414 0.049259 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.37323 A0A8P0STQ7 A0A8P0STQ7_CANLF Xg glycoprotein XG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PAGGGGGY 1 4.3 1.0039 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0.252779 0 8.20467 8.46944 A0A8P0STT0 A0A8P0STT0_CANLF Zinc finger protein 169 ZNF169 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CGRGFSQKVSLMGHQRTHTGERPYL;YVLCGHLPRIFPSSY 2 6.8 0.98947 -0.2142 7.27743 0 0 0 0 0 10.145 0 0 0 0 0 0 0 0 A0A8P0STU1 A0A8P0STU1_CANLF Phosphodiesterase (EC 3.1.4.-) PDE9A Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; metal ion binding [GO:0046872]" IDPTMPANSERTPYKVRP;PLWESRDRYEELKQ;VRPMEVAEPWVDCLL;YKVRPVAVKQLS;YLLSPETI 5 11.6 1.0021 -0.65183 0 0 0 10.6683 0 0 0 0 0 11.5164 6.81673 0 0 10.365 0 A0A8P0STU4 A0A8P0STU4_CANLF Non-homologous end-joining factor 1 NHEJ1 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via nonhomologous end joining [GO:0006303] nucleus [GO:0005634] DNA binding [GO:0003677] LEQGLLMQPWAWLQ;MGMSLALQCQV 2 8.6 0.99532 -0.56466 0 11.873 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0STU9 A0A8P0STU9_CANLF Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; tRNA re-export from nucleus [GO:0071528] cytoplasm [GO:0005737]; nucleus [GO:0005634] small GTPase binding [GO:0031267]; tRNA binding [GO:0000049] FMEVEVAIRLLYML;HFSGDVSKASALQ;SLLSSDDQL;VGIWKPYIS 4 4.7 1.0024 -0.6574 12.7737 9.1128 0 0 0 8.25285 0 13.4575 0 0 0 0 0 0 0 A0A8P0STW6 A0A8P0STW6_CANLF NADH-cytochrome b5 reductase (EC 1.6.2.2) CYB5R3 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695] endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741] "cytochrome-b5 reductase activity, acting on NAD(P)H [GO:0004128]" VGQHIYLSARIDGN 1 4.7 0.98483 -0.24644 0 0 0 0 0 0 0 0 11.5629 0 0 0 0 0 0 A0A8P0STW8 A0A8P0STW8_CANLF Phosphatidylinositol specific phospholipase C X domain containing 3 PLCXD3 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] phosphoric diester hydrolase activity [GO:0008081] TKPRDPDNELYFAH 1 4.8 0.93691 0.060945 0 0 7.90563 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0STX5 A0A8P0STX5_CANLF Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4) UBE4B Canis lupus familiaris (Dog) (Canis familiaris) ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151] ubiquitin-ubiquitin ligase activity [GO:0034450] AKLVEVMFMTNPAVQPR;ALAAKECSL;CTTCWWTDLPA;EDVAEFLFF;ENDRREKRSLSDKEPSSG;ENPEKYGFEPKKLLDQLTDI;KLLVPSLMKF;SILPSCRRYI;THLAPEGEPS 9 10 1.0034 -0.87671 0 0 0 0 0 8.40369 0 0 0 0 0 0 9.71218 0 0 A0A8P0STZ4 A0A8P0STZ4_CANLF Zinc finger protein 829 ZNF829 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] TFLTSHQK 1 2 1.0041 -1.1044 0 0 0 0 0 0 0 10.1742 0 0 0 0 0 0 0 A0A8P0SU09 A0A8P0SU09_CANLF Mini-chromosome maintenance complex-binding protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LVKVYEDWDCFKVNDVLELYGV;LVSGLLQLPNNTS;SLNEVPLHYLKPN 3 8 0.98695 -0.35838 0 0 7.09972 0 0 0 0 0 9.98613 0 0 0 0 0 11.4056 A0A8P0SU16 A0A8P0SU16_CANLF Rho GTPase activating protein 31 ARHGAP31 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] EDPGTHHEQSSPQLE;GRPDPTGLA;ILFSPPFPIMD;NSTPCRTPPKE;PESPSASPSVSILPRPE;QEPSDCDEDE;SPGLLCGDLAENTWVTPE;VTSPLHSPTLKD;WDEKTLRSFREF 9 7.8 1.0019 -1.4636 9.1918 0 0 9.99774 10.2285 0 4.26236 0 8.67546 0 0 0 0 9.69263 7.83738 A0A8P0SU31 A0A8P0SU31_CANLF Zinc finger protein 549 LOC100685462 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GKGRSAVS;TGGKPYECNECGKF 2 3.6 0.99015 -0.50998 0 0 0 0 0 0 0 0 0 11.8918 0 0 12.9408 0 12.1188 A0A8P0SU44 A0A8P0SU44_CANLF Large ribosomal subunit protein bL21m MRPL21 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; ribosome [GO:0005840] AEETRHHAEVVGKV;GSEERRTEGTDH;LLLLLLLL;LLLLLLLLL 4 8 0.94131 0.05044 8.03348 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SU50 A0A8P0SU50_CANLF tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) TSEN2 Canis lupus familiaris (Dog) (Canis familiaris) "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" tRNA-intron endonuclease complex [GO:0000214] lyase activity [GO:0016829]; nucleic acid binding [GO:0003676]; tRNA-intron endonuclease activity [GO:0000213] SEQECAPN 1 2 1.0045 -1.1044 0 0 0 0 0 0 5.92794 0 0 0 0 0 0 0 0 A0A8P0SU67 A0A8P0SU67_CANLF C2H2-type domain-containing protein LOC100685630 Canis lupus familiaris (Dog) (Canis familiaris) CGKAFTRK;EQVLHVVEKPHWDMAGGEAFQ 2 5.9 0.94938 0.050014 0 8.37426 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SU84 A0A8P0SU84_CANLF Trimeric intracellular cation channel type A (Transmembrane protein 38A) TMEM38A Canis lupus familiaris (Dog) (Canis familiaris) nuclear membrane [GO:0031965] identical protein binding [GO:0042802]; potassium channel activity [GO:0005267] GVALMSNFEQLLR;IAVGIHHAHHHY 2 8.4 0.99276 -0.15019 0 0 9.4424 0 0 0 0 0 0 0 0 0 0 0 7.20545 A0A8P0SU88 A0A8P0SU88_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDMVKPG;EVQLVESGGDMVKPGG;EVQLVESGGDMVKPGGS;EVQLVESGGDMVKPGGSLRLSCVA 7 16 0 4.8409 6.95652 0 9.2949 8.77212 8.84565 9.2926 10.2046 10.6656 10.3447 9.53257 0 9.55511 9.15944 0 8.99647 A0A8P0SU91 A0A8P0SU91_CANLF Aryl hydrocarbon receptor nuclear translocator like 2 ARNTL2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983] NDDTAMAAFMNYFEAEGGLGD;VLGHSEMREVS 2 5.4 0.99599 -0.085982 0 11.0952 0 0 0 0 0 0 0 0 9.86338 0 0 0 0 A0A8P0SU96 A0A8P0SU96_CANLF Zinc finger protein 250 ZNF250 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CENQGENQERDLGV;DFHLPQKSRDQVMAAARL;GLGSGHSECE 3 7.4 1.0001 -0.61146 0 0 0 7.44236 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SU98 A0A8P0SU98_CANLF Brix domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] rRNA primary transcript binding [GO:0042134] ALQGSLEFDDAGGEGV;PSSRLKMFAKEL 2 9.8 0.9932 -0.17606 0 0 10.455 0 8.26327 0 0 0 0 0 0 0 0 0 10.2013 A0A8P0SUA4 A0A8P0SUA4_CANLF Lemur tyrosine kinase 2 LMTK2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ADEEDENSDDSDEDLR;DAAPTDVSKQTPAS;DDVTVYLFDQE;DEDFFQSS;DEHGRGPADEA;DTGGVFKDNTLNTSPQSSPEVQ;FDLMELNGVQ;GVFKDNTLNTSPQ;LDLEVKFAENKPGFTLLQ;LDYPPALLTTEMDN;LLLLLLLL;LVNDVFANKVSIG;NLEFEESSTDEDFFQSST;VDVHEALLGSLSSHTPQ;VIVISDAADGHRGT;VLVTDPPLPEPVI 16 13.2 0.98845 -0.26249 0 0 0 0 0 0 0 0 0 0 0 0 9.34574 0 0 A0A8P0SUC0 A0A8P0SUC0_CANLF Zinc finger protein 709 LOC484934 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] EDQDENHETNLSSQ;HSAEKPYEC 2 3.9 0.9404 0.060769 7.48107 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SUC2 A0A8P0SUC2_CANLF "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase)" RARS1 Canis lupus familiaris (Dog) (Canis familiaris) arginyl-tRNA aminoacylation [GO:0006420] cytoplasm [GO:0005737] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524] FTEFYDSCYC;GFINVHLRKDFVS;KLKYRLKILRKMLKTKEQKVNPRE;NLKLKYRLKIL;VHFQTIFGAAQMIG 5 10.6 0.97411 0.041303 0 0 0 6.19722 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SUC9 A0A8P0SUC9_CANLF Perilipin 4 PLIN4 Canis lupus familiaris (Dog) (Canis familiaris) AISSGMANMVDTAKGVVQGG;KDTVCTGMIGAMNVA;LDQSPSSRLEEGI;LVSSASSVEELPAER;SSVEELPAERLAQSRGAVCQAWREL;VLSGTKDTLSTGLTGALGAA 6 5.7 1.0015 -0.91482 9.95232 0 0 0 0 0 9.01678 0 0 0 0 0 10.5762 0 10.9355 A0A8P0SUE5 A0A8P0SUE5_CANLF Zinc finger protein 217 ZNF217 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AEPPAPAFRRA;EVVQEHAAESI;IQIEGYMPLDCMFCNQ;LVEIWNSGCAGFSQ;RQRRRQRLRRAPL;TDNDDSCSEKEE;VEAEYLSPLDK 7 9 0.99119 -0.1853 0 0 0 0 0 0 0 8.92312 0 0 0 0 0 0 10.0164 A0A8P0SUE9 A0A8P0SUE9_CANLF Chromosome 17 C1orf68 homolog KPLCE C17H1orf68 Canis lupus familiaris (Dog) (Canis familiaris) ACCDCEDDCCC;CCEDSGCCSSGCCS;CCEDSGCCSSGCCSTGCC;CCEDSGCCSSGCCSTGCCGS;CCSSGCCSTGCC;CCSSGCCSTGCCGSG;CCSSGCCSTGCCGSGC;CCSSGCCSTGCCGSGCCC;CCSSGCCSTGCCGSGCCCL;CCSSGCCSTGCCGSGCCCLGI;CCSTGCCGSGCC;CDCEDDCCC;CEDSGCCSSGCCST;CEDSGCCSSGCCSTGCC;CEDSGCCSSGCCSTGCCGS;CEDSGCCSSGCCSTGCCGSGCC;CEDSGCCSSGCCSTGCCGSGCCC;CEDSGCCSSGCCSTGCCGSGCCCL;CEDSGCCSSGCCSTGCCGSGCCCLG;CNSGSSGCCEDSGCCS;CNSGSSGCCEDSGCCSSGCC;CNSGSSGCCEDSGCCSSGCCSTGC;CNSGSSGCCEDSGCCSSGCCSTGCC;CSSGCCSTGCCGSGCCCLGI;CSTGCCGSGCCC;DCNSGSSGCCEDSGCCSSGC;DCNSGSSGCCEDSGCCSSGCC;DCNSGSSGCCEDSGCCSSGCCST;DSGCCSSGC;DSGCCSSGCCST;DSGCCSSGCCSTGCCG;DSGCCSSGCCSTGCCGSG;DSGCCSSGCCSTGCCGSGCC;DSGCCSSGCCSTGCCGSGCCCLGI;EDSGCCSSGCCSTGCCG;EDSGCCSSGCCSTGCCGSGC;EDSGCCSSGCCSTGCCGSGCC;EDSGCCSSGCCSTGCCGSGCCC;EDSGCCSSGCCSTGCCGSGCCCL;GCCEDSGCCSSGCCSTG;GCCEDSGCCSSGCCSTGCCG;GCCSSGCCST;GCCSSGCCSTGCCGS;GCCSSGCCSTGCCGSGCC;GCCSSGCCSTGCCGSGCCCL;GCCSSGCCSTGCCGSGCCCLG;GCCSTGCCGSGCCC;GPACCDCEDDCC;GSSGCCEDSGCCS;GSSGCCEDSGCCSSGCC;NSGSSGCCEDSGCCSSGCCS;NSGSSGCCEDSGCCSSGCCSTGC;NSGSSGCCEDSGCCSSGCCSTGCC;PACCDCEDDCCC;PPQDCNSGSSGCCEDSGCCSSGCC;PQDCNSGSSGCCEDSGCC;PQDCNSGSSGCCEDSGCCSSGCCST;QDCNSGSSGCCEDSGCCSSGCC;QDCNSGSSGCCEDSGCCSSGCCSTG;QPPQDCNSGSSGCCEDSGCC;SGCCEDSGCCSSGCCST;SGCCEDSGCCSSGCCSTGCC;SGCCEDSGCCSSGCCSTGCCGSGC;SGCCEDSGCCSSGCCSTGCCGSGCC;SGCCSSGCCSTGCC;SGCCSSGCCSTGCCGS;SGCCSSGCCSTGCCGSGC;SGCCSSGCCSTGCCGSGCCC;SGCCSSGCCSTGCCGSGCCCL;SGCCSTGCCGSGCCC;SGCCSTGCCGSGCCCL;SGSSGCCEDSGCCSSGCC;SGSSGCCEDSGCCSSGCCS;SGSSGCCEDSGCCSSGCCSTGC;SGSSGCCEDSGCCSSGCCSTGCC;SGSSGCCEDSGCCSSGCCSTGCCGS;SSGCCEDSGCCSSGC;SSGCCEDSGCCSSGCC;SSGCCEDSGCCSSGCCS;SSGCCEDSGCCSSGCCST;SSGCCEDSGCCSSGCCSTGC;SSGCCEDSGCCSSGCCSTGCC;SSGCCSTG;SSGCCSTGCCGSGCCC;SSGCCSTGCCGSGCCCLG 85 21.2 1.004 -0.80742 10.6393 10.1215 11.2288 8.93823 8.02231 7.63713 11.9574 9.77073 9.30586 8.26393 6.27851 5.48726 11.0054 9.51649 11.068 A0A8P0SUG5 A0A8P0SUG5_CANLF Uncharacterized protein LOC610875 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CPPGCGVS;QPSPCRPS;SSCSVDDCPESY 3 15.2 1.0043 -1.0539 0 0 0 0 0 0 0 0 0 7.73633 0 0 0 5.68541 0 A0A8P0SUJ6 A0A8P0SUJ6_CANLF Large ribosomal subunit protein uL30 (60S ribosomal protein L7) Canis lupus familiaris (Dog) (Canis familiaris) "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" cytoplasm [GO:0005737] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] FAELKIKCLRKKFAQKMLRKARRK;KLAFVIRIRGINGVSP;NGVSPKVRKVLQLLRLRQIF;PAEPKLAFVIRIRGING 4 24 0.97432 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 5.83347 0 A0A8P0SUL4 A0A8P0SUL4_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) LOC106559926 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] ISQRKLKKQKLMARE;VPFCRYNGGVGRCAQAKQWGW 2 19.6 0.94472 0.10165 0 0 0 0 0 5.91172 0 6.75168 0 0 0 0 0 0 0 A0A8P0SUM1 A0A8P0SUM1_CANLF Lengsin (Glutamate-ammonia ligase domain-containing protein 1) LGSN Canis lupus familiaris (Dog) (Canis familiaris) glutamine biosynthetic process [GO:0006542] glutamine synthetase activity [GO:0004356] PSPLKTSASAPCSE 1 2.5 0.93883 0.063893 0 0 0 0 0 0 0 0 0 0 0 0 5.70551 0 0 A0A8P0SUN8 A0A8P0SUN8_CANLF YLP motif containing 1 YLPM1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAAAHWQQHQQHRVG;AEEEESELGYIPKSKWE;EMQQQQFQHLYQEW;EQLADTNSNQQKNFKM;EQQQYWYRQ;FPFIILDAINDRVRHFDQF;ILKPPGRESRPERIV;KRDYIPDRMDWERERLSDRWYPSDV;MEGGAAVTTSSSLTA;PGMPPPVMPPSL;PSAPSGNKTTVQQ;QDMDEDYNREMDR;RWREERNRDHGYDRDFRDRGEL 13 9.5 1.0012 -0.7047 9.89031 8.57716 9.214 0 5.74827 4.50176 11.8745 0 10.1335 8.09492 0 0 0 11.0177 6.07961 A0A8P0SUQ7 A0A8P0SUQ7_CANLF Sperm acrosome associated 7 SPACA7 LOC119865241 Canis lupus familiaris (Dog) (Canis familiaris) acrosomal vesicle [GO:0001669] QEDIPGVFDEILVQEML 1 10.2 0.97584 0.046227 10.0497 0 0 0 0 0 0 9.98442 0 0 0 0 0 0 0 A0A8P0SUT6 A0A8P0SUT6_CANLF Retrotransposon Gag like 9 RTL9 Canis lupus familiaris (Dog) (Canis familiaris) ENKSFLNRSQGLYDSL;GAPGPGGIPTALMR;MSAQDSVVMPPQLTP;NENKSFLNR;PASDSGALSPLLMPAPDAEALS;PLHSLRFNNMLREENVDPQNRGT;SDMMSTPKMRVPASGMMSIPLMRAP;TTSGAMSTPRMRSP;VGNPLSNENK 9 9.8 1.0033 -1.5718 0 9.4528 0 12.3181 0 15.0724 0 8.92849 9.51733 0 0 0 0 10.8583 7.8896 A0A8P0SUT7 A0A8P0SUT7_CANLF Centromere protein H CENPH Canis lupus familiaris (Dog) (Canis familiaris) kinetochore assembly [GO:0051382] kinetochore [GO:0000776]; nucleus [GO:0005634] ADCGAGGGEGGDDEPPQ;ESWDLEEKLL 2 11.7 0.99051 -0.26738 0 0 0 0 0 5.4524 0 0 0 0 0 0 0 0 0 A0A8P0SUV6 A0A8P0SUV6_CANLF Solute carrier family 37 member 1 SLC37A1 Canis lupus familiaris (Dog) (Canis familiaris) organelle membrane [GO:0031090] glucose 6-phosphate:phosphate antiporter activity [GO:0061513] VISDRLEKRAST 1 2.3 0.95504 0.05044 0 0 0 0 0 0 0 0 8.34882 0 0 0 0 0 0 A0A8P0SUW7 A0A8P0SUW7_CANLF Exportin 7 XPO7 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] cytoplasm [GO:0005737]; nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] DALDNALQTFIKLLLSI;MLPLTAAFEAVAQMF;QSASASPMDIAVQEG;TYTPEVTKAY;VLTQDHMNFIAS;VTRFLQDSVEYC;YHSIPPSFSPLVLSCLVQI 7 9.5 0.99817 -0.60513 0 5.51185 0 0 0 7.27044 10.9799 0 0 9.81068 0 4.8844 0 0 10.7706 A0A8P0SUX1 A0A8P0SUX1_CANLF stearoyl-CoA 9-desaturase (EC 1.14.19.1) SCD Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] membrane [GO:0016020] metal ion binding [GO:0046872]; stearoyl-CoA 9-desaturase activity [GO:0004768] FIDCMAALG;IDCMAALGLA 2 3.1 0.98641 -0.39175 0 0 0 0 0 0 0 0 0 12.5012 0 0 0 0 0 A0A8P0SUY4 A0A8P0SUY4_CANLF Immunoglobulin superfamily member 8 IGSF8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGAPGPGRLVAQLDT;LVGAGVAL;PGVQGSAREVLVPEGPLYRV;VTVYPYTH 4 8.1 1.0026 -1.1997 10.616 8.86802 0 0 0 0 0 7.44303 0 0 0 9.13668 0 9.84499 0 A0A8P0SUY6 A0A8P0SUY6_CANLF Zinc finger protein 793 ZNF793 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] TNLFPSIQ 1 2 0.98384 -0.24231 0 7.05767 0 0 0 0 0 0 0 0 0 0 9.73298 0 0 A0A8P0SUZ5 A0A8P0SUZ5_CANLF ZFP90 zinc finger protein ZFP90 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] EPWISEGEIQRP;RRSSLTQHERTH;TSQLERHQENWKRY 3 6.3 0.99143 -0.14544 0 0 6.23155 0 7.62322 0 0 0 0 9.05401 0 0 0 0 0 A0A8P0SV06 A0A8P0SV06_CANLF Zinc finger protein 140 ZNF140 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FSQEEWEWLQPAQRDLYRHVML;LGLNISKP;YLSFLIEH 3 8.2 1.0023 -1.8721 0 0 0 0 0 0 0 0 0 0 0 0 9.10303 12.9521 0 A0A8P0SV18 A0A8P0SV18_CANLF Coiled-coil domain containing 77 CCDC77 Canis lupus familiaris (Dog) (Canis familiaris) FQEREHVLRLYSEN;LFQEREHVLRLY;NMYQEQCMSLEEE;SKRKPVMREKVE 4 8.9 0.99254 -0.067058 7.43996 0 7.27557 0 0 0 8.22376 0 8.44369 0 0 0 0 0 0 A0A8P0SV23 A0A8P0SV23_CANLF Latent transforming growth factor beta binding protein 3 LTBP3 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] ENTRGGYRCAC;GPAPSQHLLPHPKPQH;LALLLLLLLLLG;LLALLLLLLLLLGP;LLLLLLLL;LLLLLLLLL;LTFDDCCCRQ;PLLLGKPPREED;QPGYECYCKQ;RCTCAQGYAP;RTQCIADKPEEKSL;SEEDSDECRCVS 12 8.7 0.91379 0.11121 0 0 0 5.07108 4.03975 0 0 0 5.45372 0 0 0 0 0 0 A0A8P0SV32 A0A8P0SV32_CANLF Kelch domain containing 7A KLHDC7A Canis lupus familiaris (Dog) (Canis familiaris) GKPEPPRHPHLGRGSQSSPAADSS 1 3.1 0.97367 0.041303 0 0 0 9.05308 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SV35 A0A8P0SV35_CANLF Fraser extracellular matrix complex subunit 1 FRAS1 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] membrane [GO:0016020] DGFHFSVSDTDHNHLD;DLITVDEGG;DLSTFTSVW;DQGEVRCHRQ;DVPFEAHFASEL;ENGRVLTQG;HGEQWTENACTTCICDQ;ILYGRVLWN;LENHMFNIAI;PGVDHIFF;QRKKPPMEDILEEYPL;RHGECCEECVSPAGS;SCESSCGVG;SPGVDHIFF;VCSCTHGEVRCTPQ;VEAGHQWYLQVIY;VEELSEVSNFTME;VSNFTMEDI;VSYIYVTAPRGWASL;VTDGFHFSVSDTDHNHLDN 20 5.2 0.99928 -3.1053 9.52023 0 11.6092 9.5239 0 10.3855 0 11.895 0 6.35502 6.9357 6.48132 10.3085 0 10.2092 A0A8P0SV65 A0A8P0SV65_CANLF Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) APTX Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] SKLRFRLGYH 1 3.5 0.99978 -0.61146 0 0 8.50621 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SV74 A0A8P0SV74_CANLF Proline rich 14 like PRR14L Canis lupus familiaris (Dog) (Canis familiaris) DPNCAGCDE;ELETFFAKEEE;EQQRQGALDYMLQNEEHIHQ;EVCPDSCA;IESIADHEL;LDSSMSAVVQELY;LVCEADDNHQQ;NEEVRIDIGVQN;PSGPLQDYGGTAIVQTRAGCSVLG;SEERLEGKEQ;SIADKVFCSLPYSV;STLHSAHS 12 6.9 0.99677 -4.4903 0 10.0381 0 0 8.10627 0 0 10.2607 8.12789 0 8.38849 0 0 7.99441 5.47512 A0A8P0SV76 A0A8P0SV76_CANLF tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) THG1L Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; tRNA guanylyltransferase activity [GO:0008193] IIGDAFWKEHPEILDE;NNEPLMYRKGTVL;TLAADKNEILFSEFNI 3 16 0.85552 0.15809 0 0 10.4094 0 0 7.29985 0 0 0 0 9.69209 0 0 0 0 A0A8P0SVB3 A0A8P0SVB3_CANLF Sodium/potassium-transporting ATPase subunit beta ATP1B1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890] DEMIFEDCGNMPSE;VGNVEYFGL 2 7.6 0.99202 -0.18363 0 0 0 0 0 0 0 0 0 0 0 9.82002 7.07671 0 0 A0A8P0SVE3 A0A8P0SVE3_CANLF CLOCK interacting pacemaker CIPC Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892] LSPLAANY;TLHGLESSSPLSPL;TSGSGHTG 3 7 1.0034 -1.6547 11.5018 11.5879 12.0302 8.41223 0 8.6616 10.5729 10.5762 0 0 10.4554 10.7141 0 10.0378 10.2257 A0A8P0SVI1 A0A8P0SVI1_CANLF Translation elongation factor EFTu-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GTP binding [GO:0005525] KCFVDHLFFCFLFF;PQYLPPVLI 2 6.8 0.99645 -0.57307 0 0 0 0 0 0 0 10.0474 0 0 0 0 0 0 0 A0A8P0SVI4 A0A8P0SVI4_CANLF Tetratricopeptide repeat domain 16 TTC16 Canis lupus familiaris (Dog) (Canis familiaris) ALALSPQDEGA;LDRVLESSLQAGIP;LDRVLESSLQAGIPQ;PAFGTSEELQATPQTQNGKPEGPN;YHQGQQCLEQEDWE 5 7.3 0.99564 -0.11487 0 0 3.94111 0 9.8185 0 10.283 9.52087 9.67839 0 0 0 8.15193 0 9.90354 A0A8P0SVI5 A0A8P0SVI5_CANLF C2H2-type domain-containing protein LOC102152670 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] CNECGKTFRY;ECAKSYSCSSVSI;VGETLCRNGVDGA;VHIKVHSSERPYKC 4 5.1 1.0022 -0.99173 0 0 11.3973 0 0 0 0 0 0 0 0 9.35938 9.3137 10.5752 0 A0A8P0SVJ1 A0A8P0SVJ1_CANLF "RNA transcription, translation and transport factor protein" LOC479969 Canis lupus familiaris (Dog) (Canis familiaris) AAQILRLLH;NIHSSDWPKFFEKYLRDVNCPFK 2 13.4 0.99106 -0.29631 0 12.3789 0 12.6774 0 0 0 0 0 0 0 0 0 12.7907 0 A0A8P0SVJ3 A0A8P0SVJ3_CANLF Proline rich 5 PRR5 Canis lupus familiaris (Dog) (Canis familiaris) RNTITLSVK;SCPEPQGFSDSPGQGP 2 6.9 0.9841 -0.24452 0 0 0 0 0 0 0 0 0 0 0 10.3893 0 0 0 A0A8P0SVK6 A0A8P0SVK6_CANLF "Nascent polypeptide-associated complex subunit alpha, muscle-specific form-like" Canis lupus familiaris (Dog) (Canis familiaris) GAVGSPPLP;PVTTDFFSCSS;VLPLRKDGRKKKNLQK 3 2.9 0.98734 -0.46315 0 12.2136 0 0 4.78754 0 0 0 0 0 0 0 0 0 0 A0A8P0SVN0 A0A8P0SVN0_CANLF NLR family pyrin domain containing 12 NLRP12 Canis lupus familiaris (Dog) (Canis familiaris) ELSVLITIRPTALEKLHR;FFAAMYYILDPGESR;HVEILGFSE;LASTLGVNQSLIELDLS;LVAHCGPHAAWPLA;NLSHRYTRL;SCWPEPSVP 7 9.2 1.0019 -1.2907 0 10.4896 0 0 7.19604 0 6.90905 10.0637 0 0 0 0 9.96694 0 6.62088 A0A8P0SVN8 A0A8P0SVN8_CANLF Natural killer cell cytotoxicity receptor 3 ligand 1 NCR3LG1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EDEDGMFS;ITVMGITWYWKHQASAT;LLLLPALLLLPAL;PLLLLPALLLLPALLVL;PLLLLPALLLLPALLVLV;PLLLLPALLLLPALLVLVL;VIIFVIVLVICIFKRKE;VIIFVIVLVICIFKRKEL 8 19.1 1.0026 -0.76011 5.61712 0 0 6.24717 0 4.45713 8.59223 0 7.47533 0 0 0 5.90328 6.70376 0 A0A8P0SVP3 A0A8P0SVP3_CANLF Family with sequence similarity 133 member B Canis lupus familiaris (Dog) (Canis familiaris) QEKEKTKKKKKHKKHSK;SKKKKKKA 2 9.3 0.97584 0.046227 0 0 0 0 0 0 0 0 0 5.75734 0 0 0 0 0 A0A8P0SVP6 A0A8P0SVP6_CANLF CEBPZ opposite strand LOC111091116 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GVREQDQEKWLNSK;LAKKIFKG;QSGMYGVREQDQEKWLN 3 33.8 1.0014 -0.99719 0 0 9.14453 0 10.1033 0 3.02666 0 0 0 0 0 0 0 0 A0A8P0SVS3 A0A8P0SVS3_CANLF Snail family transcriptional repressor 3 SNAI3 Canis lupus familiaris (Dog) (Canis familiaris) LVRHQESG 1 2.7 1.0041 -1.1044 0 0 0 8.33994 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SVW1 A0A8P0SVW1_CANLF CRACD like CRACDL Canis lupus familiaris (Dog) (Canis familiaris) AAKHKLLVKPRNQRSSKMRRLS;DLRFHNGSFSS;GLGGGVLL;IESGPVGY;PAGEDRGPF;SRPATPEVPEPEA;VTVLQPGGPRARRA 7 9.2 0.99741 -3.4875 0 7.93032 10.5161 0 5.91358 0 7.44245 0 0 0 6.55739 0 6.25769 0 0 A0A8P0SVX3 A0A8P0SVX3_CANLF Chromosome 6 C1orf146 homolog C6H1orf146 Canis lupus familiaris (Dog) (Canis familiaris) synaptonemal complex assembly [GO:0007130] SPLMIKYLKSIVIKESY 1 9.6 0.97908 0.046227 5.83658 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SVZ3 A0A8P0SVZ3_CANLF Citrate synthase lysine methyltransferase CSKMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] APGWVPQT;DRKPLCPG;RRALAGSLAGSCPADR 3 9.5 0.98834 -0.47526 0 0 0 7.59328 0 0 0 8.06593 0 0 5.94223 0 0 0 11.6523 A0A8P0SVZ6 A0A8P0SVZ6_CANLF DAZ associated protein 1 DAZAP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GPQGMWVP;PPPATPGA 2 4.3 0.98935 -0.2632 0 9.76079 0 0 0 0 0 0 0 0 0 0 0 10.0806 10.1352 A0A8P0SW07 A0A8P0SW07_CANLF C2H2-type domain-containing protein ZFP41 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] EVEVLKDAPKEENV 1 7.1 0.28682 0.67016 0 12.0129 0 11.0508 0 0 11.9526 0 0 11.8722 0 11.6435 11.2459 0 0 A0A8P0SW20 A0A8P0SW20_CANLF DCN1-like protein (Defective in cullin neddylation protein 1-like protein) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; spindle [GO:0005819] EAESMGFFTKEEW 1 8.5 0.98535 -0.25331 0 0 0 0 0 0 0 0 0 0 10.1755 0 0 0 0 A0A8P0SW22 A0A8P0SW22_CANLF C2H2-type domain-containing protein SALL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DEDDDEDDDEDGT;EDDDEDDDEDGTDEDS;EDEDDDEDDDEDGT;LSEDEDDDEDDDEDGTD;LSEDEDDDEDDDEDGTDED;SEDEDDDEDDD;TGTGAGGG;VPEHLDYVLTSSGL 8 4.3 1.0016 -1.2123 7.34181 0 5.54306 7.57509 0 0 4.04963 0 5.01279 0 0 0 0 0 0 A0A8P0SW31 A0A8P0SW31_CANLF Leucine rich repeat containing 20 LRRC20 Canis lupus familiaris (Dog) (Canis familiaris) EAPSELTDGHCQ;TTLPALETINLEENNI 2 13.7 0.98328 -0.25635 0 0 0 0 0 0 0 0 0 0 0 12.492 0 0 0 A0A8P0SW33 A0A8P0SW33_CANLF 60S ribosomal protein L29 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] LVKPKKVKPNIPKGGSRK 1 10.8 0.97366 0.048313 0 0 0 0 0 0 0 4.30181 0 0 0 0 0 0 0 A0A8P0SW43 A0A8P0SW43_CANLF "Mucin 13, cell surface associated" MUC13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLNSTYFCLCFFG;VIEFFGGTFRNFD;YHQTNSYHHINSDHHINSYHQTN 3 9.3 0.94014 0.060502 0 0 0 0 0 0 12.4789 0 0 0 0 0 0 0 0 A0A8P0SW44 A0A8P0SW44_CANLF "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog)" COQ4 Canis lupus familiaris (Dog) (Canis familiaris) ubiquinone biosynthetic process [GO:0006744] extrinsic component of mitochondrial inner membrane [GO:0031314] HGAGLLYP;SPDTRAPTRFVD 2 7.5 0.98954 -0.52659 0 0 0 0 0 0 10.7738 13.212 0 0 0 0 0 0 0 A0A8P0SW58 A0A8P0SW58_CANLF SOGA coiled-coil domain-containing protein SOGA3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of autophagy [GO:0010506] extracellular space [GO:0005615]; membrane [GO:0016020] GGGGGGGA;GGGGGGGG;GGRGGGGG;IILLILILVL;LGIRGSPRDSDAESDA;LIADTSTIITEARI;PIILLILILVLFSS;VGGGGGGG;VGGGGGGGG 9 7.3 0.98815 -0.49109 0 0 0 0 0 0 5.58006 0 0 3.24083 0 8.45841 0 0 0 A0A8P0SW62 A0A8P0SW62_CANLF STI1 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AQREEEARRQSGAQY;NEGVIEPDTDAPQE;TKTDEPSSEESDL 3 12.9 0.93713 0.059573 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.53306 A0A8P0SW63 A0A8P0SW63_CANLF Zinc finger protein 471 LOC119863933 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CSSFRKNW;KAFSISSQLATHQRI;LDKKSFSQNSVV;SSSPHMSPSPMNISAR;VESSQASSSSSPHMSP;YNKSGKFVYLDNVEEN 6 10.4 0.99419 -0.5619 0 0 0 0 0 0 9.20398 0 7.1811 0 12.7537 0 0 12.7134 0 A0A8P0SW66 A0A8P0SW66_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HECNICAKAFSRRY;THISSFIQHQR 2 4.8 0.93101 0.09626 0 0 0 0 6.00648 0 0 0 0 0 0 0 0 0 8.36807 A0A8P0SW74 A0A8P0SW74_CANLF Zinc finger protein 22 ZNF22 Canis lupus familiaris (Dog) (Canis familiaris) KDKERERKRERERRKKKKKKKK;KKKKKKKK;KKKKKKKKKKT;KKKKKKKTT;RKKKKKKKK;RKKKKKKKKK;RKKKKKKKKKK;RRKKKKKKKK;RRKKKKKKKKKK;RRKKKKKKKKKKT 10 9.3 1.0038 -0.81548 0 0 0 3.96042 0 0 4.24633 0 0 0 0 0 9.96795 5.87467 0 A0A8P0SW98 A0A8P0SW98_CANLF Interleukin-1 IL36G Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; inflammatory response [GO:0006954] extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] LLKEEEILALYNEMAPVEP;VTPVTITVLPCKYP 2 19.8 0.91118 0.1105 0 0 0 0 0 9.33907 9.70394 0 0 0 0 0 0 0 0 A0A8P0SWA0 A0A8P0SWA0_CANLF Membrane bound O-acyltransferase domain containing 4 MBOAT4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] LGLECLKVILRITLTAGAGLTH;LTAGAGLTHCQQLQCIFVMWSTA;PGEEGSISDADIW;YQGAAFPFALLFNYLCI 4 16.3 0.99246 -0.18394 5.72419 0 0 0 0 9.15429 0 8.84065 0 0 0 0 0 0 0 A0A8P0SWA2 A0A8P0SWA2_CANLF Chromosome 1 C9orf40 homolog C1H9orf40 Canis lupus familiaris (Dog) (Canis familiaris) FQYWRNPLPPIDLAD;GEPPLQQPPARPRGPGEEPRG;GGGGGGGG;GGGGGGGGK;GNSVRFPRNLRARQVLVRLARG;IEDVIEDNS;PGGGGGGG;VLESHFASSQE 8 15.7 0.98851 -0.34453 0 0 0 5.06242 0 0 7.71308 0 0 0 0 0 0 0 0 A0A8P0SWA8 A0A8P0SWA8_CANLF Zinc finger protein 596 ZNF596 Canis lupus familiaris (Dog) (Canis familiaris) ISHLVSIGKQLYK;MQKSHTQEDPFECSDLGENFTE;SSNLRRHEMIHTGVKPH;YECHLCGKAFTHCSHL 4 14 0.9878 -0.46119 0 0 0 0 0 0 12.097 0 0 0 0 0 8.97805 0 5.55493 A0A8P0SWC0 A0A8P0SWC0_CANLF Tousled like kinase 1 TLK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EKKENYHKHACREYRIHKELDHPRI;LHIRELKRINN;QRKLLAKRKP;VLEYCEGNDLDFY 4 7.6 0.98783 -0.48087 7.64075 0 0 0 0 0 6.65678 0 0 0 0 0 0 0 9.01647 A0A8P0SWE0 A0A8P0SWE0_CANLF Tenascin XB TNXB Canis lupus familiaris (Dog) (Canis familiaris) AGYSGDDCGV;CQDGYAGEDCGEEV;EDCGEEVP;GEDCGLRTCPSNCH;GSCPDDCNDQ;MPSSPPSASGSCPDDCNDQG;PASITFTTGLE;PEADGTLLTDLMPG;RDCRGRGRCENGV;RLHLDGYHGTAGDSMSYH;SLDGLRGHFERVV;TGLEAPQDL;TLCSLHGVFDLSRCACSCEP;VCDPGYAGDDCGSRSCPWDCGE;YEGADCGARSCPGGCHG 15 7 0.99937 -3.0991 16.6744 16.5463 16.6369 15.3995 15.4481 15.5036 16.752 16.885 16.954 17.0256 17.0467 17.2628 16.2677 16.3755 16.4094 A0A8P0SWG9 A0A8P0SWG9_CANLF DNA 3'-5' helicase (EC 5.6.2.4) (DNA 3'-5' helicase BLM) BLM Canis lupus familiaris (Dog) (Canis familiaris) DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] nucleus [GO:0005634] "3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; isomerase activity [GO:0016853]" DTSGNSKLVTPCKNH;DWEDIMHDL;EDDYDTDFVPPS;VEDMASLSAPDVFP 4 3.7 1.0015 -0.69657 0 0 9.86338 0 4.52757 0 0 0 0 9.7857 0 0 10.5424 0 0 A0A8P0SWH0 A0A8P0SWH0_CANLF TRAF3 interacting protein 2 TRAF3IP2 Canis lupus familiaris (Dog) (Canis familiaris) PLTSVCYPQDLPGPL 1 2.8 0.98722 -0.2305 8.49005 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SWI3 A0A8P0SWI3_CANLF STIL centriolar assembly protein STIL Canis lupus familiaris (Dog) (Canis familiaris) ATLKQLRSL;KVNKNAHK;LASWSQPHNF;LTEQDRQLRLLQAQI;NCYFCSPDEESM;NNCYFCSPDE;SYCPTNVCGCCQ;YNNCYFCSPDEESMTL 8 5.9 1.0007 -2.7573 10.441 0 0 8.67916 0 8.48144 0 0 11.8674 0 0 4.17425 0 7.5562 0 A0A8P0SWJ3 A0A8P0SWJ3_CANLF Cancer/testis antigen 55 CT55 Canis lupus familiaris (Dog) (Canis familiaris) KVDALCDSCHGNGPA;PLDALSRKALSVKPLR 2 12.2 0.98993 -0.19644 0 0 0 0 0 0 0 0 0 0 9.63245 0 0 0 4.14666 A0A8P0SWL3 A0A8P0SWL3_CANLF Carnitine O-octanoyltransferase CROT Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] acyltransferase activity [GO:0016746] APLDGMVIVNINHYVDQKIFE;EEGLPVPE;HLLGLLLIAKEEGLPVPELFTDPL;KRNWPNYFCNMNQRLEEWWLN;LERAKGKRNWPN;QAFTKHNKMMK;SKSGGGGN 7 14.6 1.0018 -1.8035 0 0 6.56704 8.73799 9.57622 7.67193 8.33293 0 5.82533 8.38275 0 0 0 0 8.85611 A0A8P0SWM9 A0A8P0SWM9_CANLF ferroxidase (EC 1.16.3.1) CPHL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] EKHLDILGPLIFLTP;VGSVKDLHGIYF 2 2.6 0.93886 0.10431 0 0 0 7.16872 0 0 0 0 9.03832 0 0 0 0 0 0 A0A8P0SWP9 A0A8P0SWP9_CANLF Zinc finger FYVE-type containing 27 ZFYVE27 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum tubular network formation [GO:0071787]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] AGGKCALP;AVPVPMSS;DEGAPCPAE;SDTDHGSLQRSCSN;VGALMISV;VGGGGGSW 6 11.2 1.0022 -2.5931 11.5321 11.2482 11.8565 8.34678 8.98071 9.57949 12.0109 12.0603 12.4478 12.5758 11.9811 11.918 10.5819 11.1916 12.685 A0A8P0SWQ6 A0A8P0SWQ6_CANLF nicotinate phosphoribosyltransferase (EC 6.3.4.21) NAPRT Canis lupus familiaris (Dog) (Canis familiaris) NAD biosynthetic process [GO:0009435] nicotinate phosphoribosyltransferase activity [GO:0004516] ERTRPCGGRGGSAPEPGGGAG;GVRGAGPGRGF;PDASCAGS;QELRVWPHGAREA;QEPHRGERAAF 5 10.5 1.0022 -1.4512 10.1319 0 0 10.3578 0 0 0 0 9.24909 9.85317 0 0 0 0 7.66938 A0A8P0SWS1 A0A8P0SWS1_CANLF Bifunctional lysine-specific demethylase and histidyl-hydroxylase (EC 1.14.11.-) RIOX2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506] GIPRQLLLVRVILVRVR;RAGIPRQLLLVRVILVRVRV;VFDAVKEDVALRAGIPRQLLLVRVI 3 5.5 0.87857 0.12997 0 7.00787 0 0 0 0 0 0 0 0 0 0 0 6.30281 6.13726 A0A8P0SWS2 A0A8P0SWS2_CANLF Dual oxidase maturation factor 1 DUOXA1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] endoplasmic reticulum membrane [GO:0005789] GGEGAEDREGAGEGNLG;RRGEPRGPGCARR 2 7.2 0.9867 -0.45846 0 0 0 0 0 0 0 0 0 9.34514 0 0 0 0 0 A0A8P0SWS8 A0A8P0SWS8_CANLF KRR1 small subunit processome component (KRR-R motif-containing protein 1) LOC475405 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] IKIDKELASGEYF;KQPKPEKRDESELLTV;PKQPKPEKRDE 3 9.3 1.0041 -0.83311 0 0 0 0 8.77113 0 0 0 0 0 0 0 0 0 10.3346 A0A8P0SWU0 A0A8P0SWU0_CANLF Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) GNPAT Canis lupus familiaris (Dog) (Canis familiaris) ether lipid biosynthetic process [GO:0008611]; glycerophospholipid metabolic process [GO:0006650] peroxisomal membrane [GO:0005778] glycerone-phosphate O-acyltransferase activity [GO:0016287] LVPISISYDKILEETLYV;VRPSLVAVALQ;VYELLGVP 3 5.7 1.0024 -1.0206 0 0 0 0 0 8.24911 0 0 0 6.27378 0 0 0 0 0 A0A8P0SWW2 A0A8P0SWW2_CANLF ETS variant transcription factor 6 ETV6 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] HSGDVLYE;WSRDDVAQWLKWAENEFSLRPID 2 7.6 1.0027 -0.79313 0 10.7995 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SWW5 A0A8P0SWW5_CANLF Immunoglobulin like domain containing receptor 2 ILDR2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] AFRKGYRIQADKERDSM;CPCCPDSCCCPQAF;CPDSCCCPQ;CQCCPHSCCCYIRCPCCPDS;CQCCPHSCCCYIRCPCCPDSC;DDDDDDDDSAD;DDDDDDDSAD;DDDDDDDSADD;FRKGYRIQADK;GVFTGEGCSAGLSPTPTFPD;LFFVLVGICWCQCCPHSCCCYI;LGNMDGVVLAWTALFWLT;PDSCCCPQAFR;PQDDDDDDDDDS;QDDDDDDDDD;VGICWCQCCPHSCCCYIRCPCCPD 16 12.1 0.98654 -0.23156 0 0 0 0 0 0 0 0 0 0 0 0 7.97453 0 0 A0A8P0SWW8 A0A8P0SWW8_CANLF Tropomyosin 3 LOC491979 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] actin binding [GO:0003779] AKHIAEEADR;EERAELAESRCRE;LSAVEEKYSQKEDKYEEEIKILTDK;QEIQLKEAKH;QKLEEAEKAADESESGMQVIE;VLQQQAVDA 6 37.8 1.0028 -0.98267 7.6427 0 0 0 0 0 0 8.90099 0 0 0 7.16249 5.49777 11.7436 11.1911 A0A8P0SWX9 A0A8P0SWX9_CANLF Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) MAP3K13 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709] EESDCDSSDGECSD;GILKTQPA;REKELIKREQA;YSTDYKLQQQ 4 4.7 1.0019 -1.2728 0 0 0 0 6.85275 0 0 0 0 0 5.21245 0 3.85489 0 0 A0A8P0SWZ4 A0A8P0SWZ4_CANLF SH3 domain-containing protein LOC486445 Canis lupus familiaris (Dog) (Canis familiaris) AGGRVKGK;ARGRAERQR;DDFGELTSPQGSFPI;DVLREREAEIR;EDTGHSLL;LAGLELCQAFSRQ;RYSYNPFKGPNEHPESELPLTAGDY;SEEAETQLQAALREG;SLRAGDVVTVY;VLREREAEIRQLLRWKEAEMRQLR 10 7.8 1.0028 -2.501 0 0 9.30163 0 10.0696 0 8.50855 10.9722 0 0 0 0 7.21451 7.58188 12.0126 A0A8P0SX22 A0A8P0SX22_CANLF Family with sequence similarity 184 member A FAM184A Canis lupus familiaris (Dog) (Canis familiaris) AARERLQQQASDLV;DHIKMKQQALTEFEAYKHRVEDM;EAYKHRVEDMQLCAEAQ;HVLAFQTMEEEKEK;IDLLRHSHHQ;LENHLQQKH;VIKKLIQKKK 7 7.8 0.99978 -0.61146 0 0 0 0 0 4.27635 0 0 0 0 0 0 0 0 6.02017 A0A8P0SX61 A0A8P0SX61_CANLF Spermatogenesis-defective protein 39 homolog (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) VIPAS39 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] early endosome [GO:0005769] VVREVRSSDCL 1 2.2 0.99471 -0.15528 0 0 0 0 0 0 0 0 0 12.6974 0 0 0 0 0 A0A8P0SX71 A0A8P0SX71_CANLF Sortilin related VPS10 domain containing receptor 2 SORCS2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEPGAPGL;DENQVFVAVQEWYQMD;FEEEHHVLYLD;GVQSVIQGEEFIDDD;LEVVPVVG;LLLLLLLL;RPLLLLLLLLAACG;VGVGDGDGDGE;VLQDSKVVRVL;VSHSQGVQSVIQ 10 8.3 0.98334 -0.24797 0 0 0 0 0 0 0 0 0 7.70404 0 0 0 0 0 A0A8P0SXA0 A0A8P0SXA0_CANLF Kirre like nephrin family adhesion molecule 3 KIRREL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAEEHPTIKQLMMDRGEF;ETSVTIDIQ;LFVCFFLFSQELGLQ 3 5.5 0.99728 -0.10589 0 0 0 0 0 0 13.6427 0 0 0 0 0 0 9.1235 0 A0A8P0SXB3 A0A8P0SXB3_CANLF Olfactory receptor OR6C6J Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIFVFLFLNYTLSL;VLSYTCIM 2 7 1.0039 -1.0433 0 0 0 0 0 5.9972 0 0 0 0 0 0 0 0 7.6211 A0A8P0SXB4 A0A8P0SXB4_CANLF WD repeat domain 44 WDR44 Canis lupus familiaris (Dog) (Canis familiaris) DVHLGGGYPVGS;ENTVKDSQPSL;PPRKKKSE 3 6 1.003 -0.78139 0 0 0 0 0 0 0 0 12.4547 12.7822 0 0 0 0 0 A0A8P0SXC2 A0A8P0SXC2_CANLF Solute carrier family 8 member A3 SLC8A3 Canis lupus familiaris (Dog) (Canis familiaris) cell communication [GO:0007154] plasma membrane [GO:0005886] calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872] ETRKIKHLRVFLI;EVHTNEPED;IPDGETRKIKHLRVFLI;LQKALLLSPEVT;TVTILDDDHAGI;VIVPFRTVEG;VYVDYKTED 7 7.4 1.0024 -1.8743 0 0 8.04745 4.14396 0 0 0 8.94002 7.28947 0 0 0 0 0 5.61088 A0A8P0SXD5 A0A8P0SXD5_CANLF Ribosomal protein L3 like RPL3L Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] ATSYDVTDKSITPL;DECRRRFYKD;DTTSKFGHGRFQ;QTAQEKRAF;TSRWHTKKLPRK;VRRRSIWRRKSRR 6 15 1.0018 -1.2052 0 0 7.16882 10.1751 9.11314 0 0 2.2224 0 0 0 0 4.92766 0 7.24413 A0A8P0SXE8 A0A8P0SXE8_CANLF YEATS domain containing 2 YEATS2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] KIGITLQPVAL;PPGTKLYLTTNSK;QGAILRATNNANLQSGSASGSGGG;QKVTFCSHGNSAFQPIASSCKIVPQ;VVKKIPLI 5 6.1 1.003 -1.5835 0 0 0 0 5.44248 0 9.2923 0 11.5009 0 0 0 0 3.05229 0 A0A8P0SXH9 A0A8P0SXH9_CANLF IKAROS family zinc finger 1 IKZF1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AEGPPRSNHSAQDSAVENLLLLS;FVGDKCLSDMPYDSSA;TGRVAQQTRATIH 3 8.2 0.9949 -0.15807 11.1401 0 0 0 0 0 0 11.8852 0 0 0 8.04155 0 0 0 A0A8P0SXJ0 A0A8P0SXJ0_CANLF Protein phosphatase 1 regulatory subunit 35 PPP1R35 Canis lupus familiaris (Dog) (Canis familiaris) centriole [GO:0005814]; cytoplasm [GO:0005737] phosphatase binding [GO:0019902] SPRPPRHCLALCSQ 1 4.5 0.94292 0.061104 0 0 0 0 0 0 0 7.83314 0 0 0 0 0 0 0 A0A8P0SXJ7 A0A8P0SXJ7_CANLF Ciliary associated calcium binding coiled-coil 1 CABCOCO1 Canis lupus familiaris (Dog) (Canis familiaris) EAFNARIE;GVQHLFQHY;VGGTPPLPGTR;VLEESQSEANTSDV 4 12.9 1.0019 -1.3083 0 9.93494 0 0 0 0 0 0 0 0 0 0 9.26637 0 0 A0A8P0SXK7 A0A8P0SXK7_CANLF DDHD domain containing 2 DDHD2 BAG4 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DEWKKKLESPN;DLQEMGIPLGPRKK;EGGGGDGY;ETYMLAVTLDEWKKKLESPNREII;SGKNCDGRVVPTDGGRYDVHL;VLEETYMLA;VLEETYMLAVTL 7 6.7 1.0034 -2.2484 7.24498 0 8.78542 0 0 0 10.4046 0 4.91413 13.6098 4.79629 0 0 0 0 A0A8P0SXR2 A0A8P0SXR2_CANLF Trafficking kinesin protein 1 TRAK1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] ERHESLDLLEEVLCAERVGQ;ERSKKPGTPGTPGSHDLE;ISAAVYDPQ;VAKVVNSGRAHVPT;VTSAIGGL 5 7.7 0.94858 0.050192 0 0 0 0 0 0 6.07483 0 0 0 0 0 0 0 0 A0A8P0SXS0 A0A8P0SXS0_CANLF Cadherin domain-containing protein LOC487176 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GVWAHNGEVRTARL;IQDDLPFLLRPTFKNFYTLVT;LVQVVDVNDNP;SEPWRYSVAE 4 7.2 1.0025 -1.1404 0 0 9.05953 0 0 0 0 0 0 0 0 0 0 7.78267 0 A0A8P0SXX8 A0A8P0SXX8_CANLF Tripartite motif containing 24 TRIM24 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] EKSNQVCTSCEDNA;GDQPGLHQESSSNGKS;LMLPAPMLGSAETPP;NFFVKDTTEVPS;SLPDIDCSSTIM;VGSRGSSGSSSKP;YCETCDKLTCRDCQL 7 9.7 0.99351 -0.054319 10.2382 0 11.3723 10.0244 3.56255 0 0 0 0 0 0 0 8.24512 7.6953 0 A0A8P0SXX9 A0A8P0SXX9_CANLF Calcium/calmodulin dependent serine protein kinase CASK Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AWSSPSSPVPHWSSPECLFL;EPMGITLKMNELNHCIV;LFEDVYELCEVIGKGP;LNEDESLQRLQKE;RVRLVQFQKNTDEP;VPSYRTQSSSCERDSP 6 10.3 0.99064 -0.26801 6.0203 8.76875 0 0 8.91325 9.95745 0 0 0 0 0 8.9046 9.88675 0 0 A0A8P0SXZ0 A0A8P0SXZ0_CANLF Metalloprotease TIKI (EC 3.4.-.-) (TRAB domain-containing protein 2) TRABD2B Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of Wnt signaling pathway [GO:0030178]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] plasma membrane [GO:0005886] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AFGAGHFL;AVERVEEQCHPLNGLN;DVLPRDLYWRLKR;TPAGQTIHSPA;TQLHQGHTYRVCGNLNSP 5 12.2 0.99305 -0.064408 0 7.92077 0 7.71603 0 5.85504 0 10.0181 0 0 0 0 0 0 7.31895 A0A8P0SXZ3 A0A8P0SXZ3_CANLF procollagen-proline 3-dioxygenase (EC 1.14.11.7) P3H2 Canis lupus familiaris (Dog) (Canis familiaris) collagen metabolic process [GO:0032963] endoplasmic reticulum [GO:0005783] "dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" ITFVYNSE;LPLLPLPLLLLLLPPPLW;PLYRELERIQADEVIAILD;SGVNVEGPEVHGLS;YEYLGYKAGLYEAIADH 5 11.2 1.0031 -1.5026 0 0 0 0 4.37281 6.96162 0 0 6.81237 7.78947 0 0 0 0 0 A0A8P0SXZ9 A0A8P0SXZ9_CANLF Gasdermin D GSDMD Canis lupus familiaris (Dog) (Canis familiaris) programmed cell death [GO:0012501] membrane [GO:0016020] LSIRDILEP;LVQSILEQ;QSTPWQERRAVSLP;QTQKEVTVTWIYKQEGSGQFSL 4 11.8 1.003 -2.1126 9.38271 0 0 0 0 9.69591 0 0 0 0 0 0 0 10.7627 0 A0A8P0SY03 A0A8P0SY03_CANLF Plexin A1 PLXNA1 CHCHD6 Canis lupus familiaris (Dog) (Canis familiaris) MICOS complex [GO:0061617]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; kinase activity [GO:0016301]; semaphorin receptor activity [GO:0017154] CWLVPHPSPGQRGA;DRGSKMVSEIYL;EPQPGVRPVALEPGRAAARPLSSCH;IHCRSPSARE;KKHFLLTFIRTLEAQ;LLLPLLLLL;LLLPLLLLLL;LLLPLLLLLLLRGAQGAAGAPR;LLPPLPPLLLLPLLLLLLL;LPPLPPLLLLPLLLLLLLRGAQ;LRVLLPPLPPLLLLPLLLLLLL;LVKNHDHLDQREGDRGS;NSCLVYNDTTMV;PLLLLPLLLL;PLLLLPLLLLL;PLLLLPLLLLLLL;RESCGLCLKADP;RGGAGPGA;SLRVLLPPLPPLLLLPLLLLLL;SLRVLLPPLPPLLLLPLLLLLLLRG;VLLPPLPPLLLLPLLLLLLLR;VSVGGRPCS;YVYSFRSEQFVYYLTLQ 23 8.2 0.99339 -0.062458 0 0 0 0 6.54291 7.02292 0 0 10.0045 0 3.83794 0 0 6.68131 7.16058 A0A8P0SY04 A0A8P0SY04_CANLF Voltage-dependent L-type calcium channel subunit alpha CACNA1S Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated calcium channel complex [GO:0005891] metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245] AFRVLRPLRL;AVIGMQMF;EGLNKIIQFVRHWRQWNRIFRWKCH;EKAKSRGTFQKLREK;GVPSLQVVLNSIF;IEAAMKIIAYGFLFHQDAYL;ISVVKILRVLRVLRPL;ISVVKILRVLRVLRPLRAI;KSPQRAGP;LESSTISVVKILRVLRVLRP;NRNNNFQTFPQAV;SPLGISVLRCIRLLRIFK;STISVVKILRVLRVLRP;SVVKILRVLRVL;SVVKILRVLRVLRPLRAINRA;TISVVKILRVLRVLRPLRAINRAK;VLRVLRPLRAINRAKG;VVQCVFVAIR 18 8.9 0.92238 0.12021 10.1148 7.03881 9.04243 5.53574 6.2163 7.15451 0 0 8.96503 0 0 6.69432 0 7.84317 0 A0A8P0SY47 A0A8P0SY47_CANLF TELO2 interacting protein 2 TTI2 Canis lupus familiaris (Dog) (Canis familiaris) TTT Hsp90 cochaperone complex [GO:0110078] NPATKHVFSWSL;RLVVLLKALLKL 2 5 0.97336 0.038482 0 0 0 0 0 0 0 0 0 0 10.7748 0 0 0 5.03848 A0A8P0SY49 A0A8P0SY49_CANLF "ASPSCR1 tether for SLC2A4, UBX domain containing" ASPSCR1 Canis lupus familiaris (Dog) (Canis familiaris) PVDRDPVVCHPDLE 1 2.8 0.94304 0.061102 0 0 0 0 0 7.65284 0 0 0 0 0 0 0 0 0 A0A8P0SY51 A0A8P0SY51_CANLF DNA helicase MCM9 (EC 3.6.4.12) (Minichromosome maintenance 9) MCM9 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508] chromosome [GO:0005694]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677] AHARLMFRDT;EGSPCPDPLSHQG;GVNALHTSFPENPLEQ;KHVFVVKA;LILEKLELHNLLSEELRR;PNEVLTVFDSAL;PRSMKVIL;QVQRLSVGSIPRSMKV;VSEAAIPVGE 9 9.8 1.0014 -2.6585 0 0 8.36593 7.25427 8.89294 7.81596 10.0757 0 0 13.6506 7.57008 8.0789 10.7624 9.43459 8.0713 A0A8P0SY56 A0A8P0SY56_CANLF RCC1 like RCC1L NCF1 Canis lupus familiaris (Dog) (Canis familiaris) GAPPRRIQPV;GIGRLEDQY;YFPWRVTMPGEPV 3 7.2 1.0023 -1.356 7.38914 0 0 0 0 0 0 8.30702 6.69655 0 0 0 0 0 0 A0A8P0SY63 A0A8P0SY63_CANLF RAP1 GTPase activating protein 2 RAP1GAP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of small GTPase mediated signal transduction [GO:0051056] GTPase activator activity [GO:0005096] KFGVIYQKARQT;KRYVQEGRFRI;SQMIVSYDEHDVNNTFKFG;VESVYTVFR 4 6.2 0.99009 -0.26704 0 0 0 0 0 0 0 11.7647 0 0 0 0 0 0 0 A0A8P0SY77 A0A8P0SY77_CANLF RAS related RRAS Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] MKPLGGFQPWDLCSGL 1 5.5 0.95604 0.049233 0 0 0 0 0 0 8.30547 0 0 0 0 0 0 0 0 A0A8P0SY82 A0A8P0SY82_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) EPHB1 Canis lupus familiaris (Dog) (Canis familiaris) nervous system development [GO:0007399] dendrite [GO:0030425]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003] ATITAVPSQPLLDR;NITTNQAAPSTV;TLSWPQPEQ 3 3.8 0.98535 -0.43046 0 10.5773 0 0 0 0 11.8043 9.63329 0 0 0 0 0 4.18872 0 A0A8P0SY86 A0A8P0SY86_CANLF Neuroligin 3 NLGN3 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; synapse assembly [GO:0007416] plasma membrane [GO:0005886] carboxylic ester hydrolase activity [GO:0052689]; neurexin family protein binding [GO:0042043] EVAWSKYNP;FFGGDPRRITVFG;RKTLVALFTDH;TDHQWVEPSVVT;VGCNVLDTVDM;VGPTDLFPCNFSKN 6 8.8 1.0026 -0.89925 8.29425 0 0 0 0 0 0 11.7835 9.35387 0 0 0 0 8.94486 0 A0A8P0SYB3 A0A8P0SYB3_CANLF Copine 5 CPNE5 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent phospholipid binding [GO:0005544] AEELSNCRDVATMQF;FDAMVELDGDDVR;FDAMVELDGDDVRISSRGKL;SGGVPGKK;VISDMAQTKEAI 5 9 1.0024 -1.0223 0 0 0 0 0 0 0 0 0 0 0 11.2086 8.65532 8.55605 10.5783 A0A8P0SYC4 A0A8P0SYC4_CANLF Cytochrome c oxidase assembly factor COX14 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] CSARAYRYFQW 1 15.3 0.98407 -0.24721 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85775 A0A8P0SYE3 A0A8P0SYE3_CANLF Sorting nexin 25 SNX25 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] DLQLHMARTDW;ISVEKSLYKEIQ;LHLGCAAAA;QEEEAEEDSDLSDYGDD 4 5.1 1.0029 -1.008 0 0 8.42664 9.76823 0 6.8125 0 0 0 0 0 0 0 0 0 A0A8P0SYH8 A0A8P0SYH8_CANLF Bromodomain testis associated BRDT Canis lupus familiaris (Dog) (Canis familiaris) EKRLLDVNNQL;LEKVFKQQVIPSVF;LQVLSQVPFHKLKKKSKSKR;LSQVPFHKLKKKSKSKREKKK;SSSSDSSSSDSSDSESDKTSAK;VFTSKPEDEDNAK 6 9.3 0.97337 0.046699 0 5.05745 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SYJ3 A0A8P0SYJ3_CANLF Desmin DES Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] PATPPPGPARASW;TSPEQRGSEVHTKKTVMIKT 2 5.3 0.9192 0.10907 0 0 0 0 0 7.1643 0 0 0 9.27174 0 0 0 0 0 A0A8P0SYJ9 A0A8P0SYJ9_CANLF Diaphanous related formin 3 DIAPH3 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036] actin binding [GO:0003779]; small GTPase binding [GO:0031267] FEKMMEDMNL;LSSLCKLKDTKSADQ 2 2.2 0.93968 0.070092 0 0 0 0 0 0 0 0 0 0 0 0 0 8.83536 0 A0A8P0SYN0 A0A8P0SYN0_CANLF DENN domain containing 1B DENND1B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410] guanyl-nucleotide exchange factor activity [GO:0005085] EVSENEKGKTEKK;LDGALYDD;QSTATGDGV;SGGFCGGN 4 5.4 1.0012 -2.7108 0 0 0 0 0 0 0 0 0 0 0 0 8.14705 0 0 A0A8P0SYP7 A0A8P0SYP7_CANLF Zinc finger protein 655 ZNF655 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CSECGEAFGQTSC;DLYREVMLEN;KTYEFNDCGLTF;PEPLFEQDTD;QDLQVFDL;SENNECNEPEKSFS 6 10.9 1.003 -1.4966 0 0 4.90304 0 0 0 10.4848 5.67632 0 0 0 4.48175 12.5265 0 0 A0A8P0SYQ5 A0A8P0SYQ5_CANLF Acyl-CoA synthetase family member 3 ACSF3 Canis lupus familiaris (Dog) (Canis familiaris) fatty acid metabolic process [GO:0006631] nucleotide binding [GO:0000166] ALQGKANSGKGK;DFVRAVCEERIRFRGDP;LLRPVVKKLGVP;VTGLVHKW 4 12.2 0.9914 -0.26979 0 0 8.64713 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SYR6 A0A8P0SYR6_CANLF Nucleophosmin Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] AADEDDDDDGDDDD;AADEDDDDDGDDDDD;AADEDDDDDGDDDDDEDDD;ADEDDDDDGDDDDDEDDD;DDDDDEDDDDDDDFDDEE;DDDDDEDDDDDDDFDDEEA;DDDDEDDDDDDDFDDEEAE;DDDDEDDDDDDDFDDEEAEEKA;DDDEDDDDDDDFDDE;DDDEDDDDDDDFDDEEA;DDDEDDDDDDDFDDEEAEE;DDEDDDDD;DDEDDDDDDDFDDEEAE;DEDDDDDD;DEDDDDDDDFDD;DEDDDDDDDFDDEEAEE;EDDDDDDD;EDDDDDGDDDDDEDD;EDDDDDGDDDDDEDDD;EDDDDDGDDDDDEDDDD;EKAPVKKSIRDIPAKN;ELHIVEAE;GDDDDDEDDDDDDD;GDDDDDEDDDDDDDF;GDDDDDEDDDDDDDFD 25 20.4 0.94635 0.081943 7.502 0 0 3.66573 4.99883 10.0031 0 0 0 0 8.33226 0 3.96135 10.0588 0 A0A8P0SYT5 A0A8P0SYT5_CANLF Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) ARHGAP26 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoskeleton [GO:0005856]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925] GTPase activator activity [GO:0005096] DICAEWEIKTITSA;LEDERIRMAD;LFTFYHHGYELAKDFSDFKTE;VESLMKKMKENPLEHKTISPYTME 4 9.8 0.99394 -0.030987 7.52669 0 0 0 0 0 10.6398 0 0 14.7135 0 0 0 9.67719 0 A0A8P0SYU5 A0A8P0SYU5_CANLF Solute carrier family 25 member 25 SLC25A25 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] mitochondrial inner membrane [GO:0005743] calcium ion binding [GO:0005509] DKKNDGRIDAQEIMQSLRDL;KKLRLVFKSL 2 6.5 1.0024 -0.84264 0 0 5.99603 0 0 10.2251 0 0 0 0 0 0 0 0 0 A0A8P0SYV3 A0A8P0SYV3_CANLF Protein HIRA HIRA Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] LSVQVSSDP;PCCPGVTEAL;SSDPSMYIE 3 2.4 1.0019 -1.2047 0 0 0 0 8.81404 0 0 0 0 0 0 0 6.34078 0 0 A0A8P0SYW2 A0A8P0SYW2_CANLF Potassium voltage-gated channel subfamily Q member 2 KCNQ2 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] AKDPEPAP;LDFLVNIYMQRMGIPPTETEA;VGRGPALT;WAAGCCCRYRGWR 4 6 0.9425 0.059561 0 0 0 0 3.67627 0 0 0 0 0 0 0 0 0 0 A0A8P0SYX3 A0A8P0SYX3_CANLF Ribosomal protein L3 like RPL3L Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] DECRRRFYKD;VGGLRWREPEA;VHRHHLQVWPR 3 7.6 0.98788 -0.49644 0 0 8.34399 0 6.50878 0 12.1042 0 0 0 0 0 0 0 0 A0A8P0SYX4 A0A8P0SYX4_CANLF Ladinin 1 LAD1 Canis lupus familiaris (Dog) (Canis familiaris) structural molecule activity [GO:0005198] DEDEDEDEDVQAI;GACEDDGCDWT;SGEQDPQEVG;SPGSSRAEF 4 5.2 1.0041 -0.81181 0 0 0 9.38159 0 0 0 0 8.93531 0 0 0 0 3.94739 7.26125 A0A8P0SYY3 A0A8P0SYY3_CANLF SZT2 subunit of KICSTOR complex SZT2 Canis lupus familiaris (Dog) (Canis familiaris) peroxisome [GO:0005777] AFVDEGGSPISL;DLHDSHVC;DSFSTDDDNDVE;ELEELLEAVHAKSIGDIDPQLDC;FEQHLSSEP;GVACITLAFVDEGGSPISL;ISLTDICQL;LPLDYRAPFLLT;LPSEVLHLALPVACR;LPSVLSEFTTL;LTPADVEFIQPPGSL;MLVRNCKLTPADVEFIQ;QEVDITPFLLALCGH;RQRFLLLEV;SMLSFEYLIQLCQSK;TESVRTPGGTE;VGQQPGGSQREPPST 17 6 0.99703 -3.6727 9.24636 10.5614 0 8.06862 0 0 10.0821 8.53784 0 12.2969 0 0 7.2635 11.185 0 A0A8P0SYY7 A0A8P0SYY7_CANLF SR-related CTD associated factor 4 SCAF4 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AVEESKKEDAAATATATP;GARVCAGP;HLQRFPLM;IPKPLPVPVP;IPPPGFGP;QPAYTQHQNMDQFQPR;RGAGGGAG;VIPPTPPVQ 8 6.4 0.99713 -3.6146 0 10.4843 0 4.58135 0 0 6.85212 0 7.64126 0 5.28025 0 0 0 0 A0A8P0SZ07 A0A8P0SZ07_CANLF RING-type domain-containing protein RNF216 Canis lupus familiaris (Dog) (Canis familiaris) transferase activity [GO:0016740]; zinc ion binding [GO:0008270] KIEKRMFFLENKRRHCRSYDRRALL;PGAPCQECSRCSLW;QECSRCSLW;RIWKHYENNIISFCRLCNFLLEN;TSELEKVL;VESSQELRMLLC;VNYDFAPVHMPLEHNL 7 16 0.99625 -0.58036 10.8196 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SZ25 A0A8P0SZ25_CANLF MyoD family inhibitor domain containing 2 Canis lupus familiaris (Dog) (Canis familiaris) DESHSRNDRNCNCDMDCS;NCDMDCSLFESCHETSEC;NDRNCNCDMDCSLFESCHET;QFWDCLLMLPDT 4 21.7 0.97406 0.041966 14.7515 0 0 6.99944 0 0 0 0 15.3256 0 0 0 10.2788 0 0 A0A8P0SZ26 A0A8P0SZ26_CANLF Zinc finger and BTB domain containing 9 ZBTB9 Canis lupus familiaris (Dog) (Canis familiaris) CPHGSHPL;RSSSFQAPVQSS 2 4.2 0.98754 -0.46056 0 0 0 0 0 0 0 0 9.69547 0 0 0 0 0 0 A0A8P0SZ30 A0A8P0SZ30_CANLF Olfactory receptor OR3A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YGSGIFNYMR 1 3.1 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 10.0151 0 0 0 A0A8P0SZ35 A0A8P0SZ35_CANLF alpha-L-fucosidase (EC 3.2.1.51) FUCA1 Canis lupus familiaris (Dog) (Canis familiaris) fucose metabolic process [GO:0006004] alpha-L-fucosidase activity [GO:0004560] DTYWNSTEFLSWLYNDSPVK;GEWECPDT;NCQDKYKPESLPDHKWEMCT;PELYDLVNRYEPDLIW;PPPLPLPLPLLLLL;VGLGPPPPLPLPLPLLLLLGAALV 6 20.2 0.97387 0.041303 4.36849 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SZ41 A0A8P0SZ41_CANLF FAT atypical cadherin 1 FAT1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AILPLEIFIT;CNCSQDYRGRHCEDAAP;DIQIVSLQPSE;EAGNELDLFSLNPNSGVLSLK;FDVVVEVTQEQKP;FIEIYIEVE;GLITTTSRKLDREQQDEHILE;IIVEDINDNP;IVSGNDDGAFEVN;LFAEYAANV;LKIEARDQAREE;LPTPLRTATPS;LSTSETLD;NGGTCFDSLDGAVCQCDSG;QFRATKYEVDIGSNAPKGTSV;QVRATDSDSEPNRGISYHM;TATEDCSSSPCQNGG;TYSIISGNEHGKF;VPVGSSVM;YLLHVKVADNGKPQLSS 20 6.5 0.98202 0.035491 0 0 8.75158 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SZ43 A0A8P0SZ43_CANLF F-box protein 2 FBXO2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DTTQPAIVAKDWYSGRS 1 5.7 0.9933 -0.14321 0 12.0362 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SZ54 A0A8P0SZ54_CANLF Antizyme inhibitor 2 AZIN2 Canis lupus familiaris (Dog) (Canis familiaris) polyamine biosynthetic process [GO:0006596] catalytic activity [GO:0003824] HHVSGPCPPSGELQ;LDQPGREE 2 5.1 0.9842 -0.2442 0 0 0 0 0 0 0 9.08874 0 0 0 0 0 0 0 A0A8P0SZ65 A0A8P0SZ65_CANLF ADAM metallopeptidase domain 15 ADAM15 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] CAQCCFGC;CGFPDDCTDPCCDY;DCGFPDDCTDPCCDY;DCGFPDDCTDPCCDYFTCQ;DLVEISQDPGLTLDNFL;DPCCDYFT;EPGEQCDCGFPDDCTDPCCD;EQCDCGFPDDCTDPCC;EQCDCGFPDDCTDPCCD;FPDDCTDPCCDYFTCQ;GEQCDCGFPDDCTDPCC;GEQCDCGFPDDCTDPCCD;GLCCQNCQLRP;GVCDSKGHCHCEEGW;LPLSLLLVVVLVLLGA;MFVEPGEQCDCGFPDDCTDPCC;PGEQCDCGFPDDCTDPCC;PGEQCDCGFPDDCTDPCCD;QCDCGFPDDCTDPCCD;RVQGHASS;VEPGEQCDCGFPDDCTDPCCD 21 12.1 1.0044 -1.1044 0 0 0 0 0 0 6.1604 0 0 0 0 0 0 0 0 A0A8P0SZ68 A0A8P0SZ68_CANLF Fc receptor like A FCRLA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GCHAAAPF;PSKNPGFSSPLQ;SSVAIKIQ 3 7.1 1.0016 -1.3128 0 9.21327 0 0 0 0 0 0 0 0 0 8.66103 0 0 8.65173 A0A8P0SZ88 A0A8P0SZ88_CANLF ferroxidase (EC 1.16.3.1) CP Canis lupus familiaris (Dog) (Canis familiaris) copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] AAVEVEWDYSPSREWE;CLSKMYYSAVDPTKDIFTGLIGP;ELHLLQEQNVSN;LDNEKEKNID;LGIFLFLYSN;LVMQPDTPGTF;SVHFHGHS;TVPEEVGPTYKD;VEVEWDYSPSREW;WNVNYSFILSAI 10 10.4 0.9843 -0.25292 0 0 0 0 0 0 0 0 0 0 0 0 0 9.14659 0 A0A8P0SZ90 A0A8P0SZ90_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LLEEINEKRESNCFVERSNQVS;NEKRESNCFVER;VSDYHLYLML 3 19.9 1.0041 -0.80956 7.36798 0 0 0 0 8.30524 0 0 0 0 0 7.87338 0 0 0 A0A8P0SZ99 A0A8P0SZ99_CANLF Cadherin domain-containing protein LOC119863934 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] GAPRLLVSLLLL;KKKKKKKGNKTQ;KKKKKKKK;KKKKKKKKGNKTQEKKEKG;LEVNLQNGILFV;QENALVSYSLVERR;SNSWTFKYGP;SVHLEEAGILRAG;TKKKKKKKK 9 8.6 0.95191 0.05044 4.32531 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0SZC5 A0A8P0SZC5_CANLF Coronin CORO1B Canis lupus familiaris (Dog) (Canis familiaris) stress fiber [GO:0001725] AEELYRLDSLH;CCCCCYCCWPL;CCCCCYCCWPLA;CCCCCYCCWPLAW;CCCCYCCW;CCCCYCCWP;DLIYNVSWNR;LSCCCCCYCC;LSCCCCCYCCW;PALSLLSCCCCCYC;RQLALWDPENLEEPMALQ;SCCCCCYCCW;SLLSCCCCCYCC 13 11 1 -2.8212 7.17053 10.0463 4.62877 8.50327 6.62861 0 6.59207 6.04017 6.26577 8.88539 8.61272 0 5.36468 0 0 A0A8P0SZD2 A0A8P0SZD2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RWQETDMLEMETQKAV 1 11.9 0.95791 0.049233 0 0 0 0 0 0 0 0 0 6.54942 0 0 0 0 0 A0A8P0SZF5 A0A8P0SZF5_CANLF very-long-chain enoyl-CoA reductase (EC 1.3.1.93) TECR Canis lupus familiaris (Dog) (Canis familiaris) fatty acid biosynthetic process [GO:0006633] endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]" EILDAKTREKLCF;EKLCFLDKVEPHATIAEI;LETLFVHRFSHGTM 3 13 0.9877 -0.46048 0 0 0 8.12995 0 0 11.5265 9.93671 0 0 0 0 9.55075 0 0 A0A8P0SZG0 A0A8P0SZG0_CANLF N-6 adenine-specific DNA methyltransferase 1 N6AMT1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676] IVIVVFILASSFWK;YVVTPPEEVGS 2 9.8 0.93035 0.09626 0 0 0 9.04527 0 0 0 0 0 12.8577 0 0 0 0 0 A0A8P0SZG8 A0A8P0SZG8_CANLF PH domain and leucine rich repeat protein phosphatase 2 PHLPP2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] cytoplasmic vesicle [GO:0031410]; endomembrane system [GO:0012505]; membrane coat [GO:0030117] ALLCYIRPDTADPASS;DITYLNLRHNFMQLE;ETLAECQRWQRQA;GVLHTSVVLLTEMCERSP;GVLNRMSHIR;ISDPFLQVRILRLLRILG;KDRMELQKSPSTSCL;LEEVQQSTN;LQVRILRLLRIL;LQVRILRLLRILG;LTELNLSCNGFHDLPSQ;PTTPSSSSGIA;RKGKTQLHKWAE;TLGCMGSSEMCRDLA;VDCLKDLDVSI 15 8.4 1.0014 -1.8091 0 0 11.7103 0 10.8723 2.75003 10.3144 10.9396 6.13691 0 10.1015 9.45896 7.92463 9.97771 0 A0A8P0SZK1 A0A8P0SZK1_CANLF Methyl-CpG binding domain protein 3 MBD3 Canis lupus familiaris (Dog) (Canis familiaris) intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] ADEDDEDDEDEDEDEPD;DDEDDEDEDEDEPDQDQ;DEDDEDDEDEDEDEP;DEDDEDDEDEDEDEPD;DEDEPDQDQEME;EDDEDDEDEDEDEPD;EDDEDDEDEDEDEPDQ;EDDEDEDEDEPDQDQE;GADEDDEDDEDEDEDEPDQD;RTGKMLMSKMNRSR 10 16.2 0.85654 0.19158 7.72233 10.1299 0 0 4.81388 4.7052 5.98475 5.45418 0 0 5.81078 0 7.40888 0 6.77452 A0A8P0SZL4 A0A8P0SZL4_CANLF ETS homologous factor (ETS domain-containing transcription factor) EHF Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] FVKKKKKKEKKRKRKK;HNPRGTHLWEFIRDIL;VKKKKKKEKKRKR;VKKKKKKEKKRKRKK 4 9.4 0.81203 0.2119 0 0 6.66121 0 0 4.73752 7.47598 7.18378 0 0 0 8.26402 0 0 7.46899 A0A8P0SZL5 A0A8P0SZL5_CANLF G protein-coupled receptor kinase (EC 2.7.11.-) GRK5 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703] LNEKQILEKVN;LNEKQILEKVNSQFVVN;VGPGMPQAQHQNNSKSSPNPK 3 6.2 0.99338 -0.15978 8.37352 0 0 0 0 0 0 0 8.62801 0 0 0 0 6.43671 0 A0A8P0SZN1 A0A8P0SZN1_CANLF Annexin ANXA9 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544] LSIRAEFKKKF 1 3.5 0.97825 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 7.6969 0 0 A0A8P0SZR9 A0A8P0SZR9_CANLF Chromosome 9 C17orf80 homolog MTNAP1 C9H17orf80 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ENFSSGDSA;ESKKRNTDL 2 3.4 1.0038 -1.0403 0 0 0 0 0 0 0 0 0 0 0 0 0 9.75609 9.55616 A0A8P0SZS1 A0A8P0SZS1_CANLF Prolactin receptor (PRL-R) PRLR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] AENHCFASSKEHEG;CILPPVPGPKIK;LVQVRCKPDHGFWSEW;PSLLSKKCEEARADPS 4 7.4 0.99124 -0.29615 0 0 10.5919 0 0 0 0 0 0 9.86247 0 8.12774 0 9.18847 10.1098 A0A8P0SZV0 A0A8P0SZV0_CANLF Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1) KCNAB1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; plasma membrane [GO:0005886] oxidoreductase activity [GO:0016491]; voltage-gated potassium channel activity [GO:0005249] GSIIKKKG;KVEVQLPELYH 2 5.2 0.9934 -0.27979 0 0 12.5609 9.67069 0 0 12.899 0 0 0 0 0 0 0 0 A0A8P0SZW6 A0A8P0SZW6_CANLF Cullin associated and neddylation dissociated 2 (putative) CAND2 Canis lupus familiaris (Dog) (Canis familiaris) SCF complex assembly [GO:0010265] EALDILSDML;EFSEQESEDEYSDDDDMSW;GDEEQMETEDNEFSEQESED;ICEFLNHVEDGLKDHYDIRM;ISDQPHPIDPLLKSFIGEFMES;LLRLLRSPLLPA;PDSLKPYAEDIWALL;PNVTSLCLQYIK;QMETEDNEFSEQESEDEYSDDDDMS;SLPPPKLAEYQPLSRRDPGRSG;TEDNEFSEQESEDEYSD;VGRQAGHRLGAHL 12 11.2 1.0046 -1.0473 6.57962 10.5712 0 0 0 0 7.81737 9.00593 11.9054 0 7.48527 0 7.9867 8.78077 10.1667 A0A8P0T003 A0A8P0T003_CANLF Olfactory receptor family 56 subfamily A member 9 OR56A9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ILILRAILRLKAK;LEASLHEPMYYLLGLLSL;LIFISYILILRAILRLKAKG;LVLIFISYILILRAILRL;LVLIFISYILILRAILRLK;NFLPMESCTFLAMAYDRYVAI;SYILILRAILRLKAKGAAA 7 20.7 0.93688 0.074992 0 0 4.90694 0 0 5.46215 9.87532 0 9.56003 9.38409 0 0 0 5.22751 9.53807 A0A8P0T027 A0A8P0T027_CANLF Capping protein regulator and myosin 1 linker 3 CARMIL3 Canis lupus familiaris (Dog) (Canis familiaris) AGAQALQEQLGTVT;EQAGQDIQN;GFGGSQGPSFRRKMGTEGAEP;GLFHFRRPRSFKGDRGP;KLRTSILINALGS;PNALMHLDLAG;PRPPRTTPPGPGRPSM;SLKHLFLG;SLQSLSVADSRLKLRTSI;VDTIYHAEDNREFNLLDFSH 10 9.8 0.97747 0.047716 0 0 0 0 0 0 0 0 0 0 9.3864 0 0 0 0 A0A8P0T035 A0A8P0T035_CANLF TUB like protein 4 TULP4 Canis lupus familiaris (Dog) (Canis familiaris) FGTADGQVIV;ILKGRRISKLRPE;LDSCNCSDSSDVE;LVSPPPTDLQSHLGTE;NFNLRGHNSEVVLV;RPDSLIHATLRR;VTGTSGVPENNPP 7 6.1 0.98909 -0.5073 0 0 8.28512 11.9988 0 0 0 11.0152 0 6.03527 0 10.0811 0 0 0 A0A8P0T041 A0A8P0T041_CANLF Multiple EGF like domains 11 MEGF11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APRVSYTPAMRMTSTDYSL;CCPGYYENGDFCIPLCTE;CFSNEGCDSDHWGPHCSNRCQCQN;CNESCPAGYYGN;CSCENGGSCSPEDGSCEC;CSQDCPCHHGGQCDHVTGQCHC;EGLHGSGC;FGYGCQQLCECMNN;GPACFHTCSCH;HVSGKCTCRTGF;IVLLLFLIVVLLGLFAWRRRRQ;LLLFLIVVLLGLFAWRRRRQK;NGGSCSPEDGSCECA;PVTGHCCC;RGSPYTDMPSLST;SPATGACECEPGYKGP;TGVYCEELCPPGSH;VLLLFLIVVL;VPCAAGTYGPNCSS;WGPACFHTCSCHNGGSCS 20 23.1 0.97132 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.11193 A0A8P0T052 A0A8P0T052_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DKEHQCIVKDKRNK;ICLLEDIIPD 2 11.9 0.98923 -0.19982 0 0 0 0 0 9.33365 0 0 0 0 11.1148 0 0 0 0 A0A8P0T058 A0A8P0T058_CANLF Trio Rho guanine nucleotide exchange factor TRIO Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085] DLDLEGQKLLQRIQS;EEIYQAAHQLEDRIQDFVRRVEQ;HYWTMRKRRLDQCQQYVVFERS;LLAGRKKLLLLPG;SEQVCSVLESLEQEYK;SLRMEKYRTSLEKA;VGKSLHRA;VGKSLHRARAL;VRLHQRLQLCVF 9 8.4 0.94051 0.059561 0 0 0 3.1321 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T087 A0A8P0T087_CANLF KH type-2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] RNA binding [GO:0003723] TEIINLAIRMQNILGEKGQ 1 12.4 0.98209 -0.25071 0 0 0 0 0 0 0 0 0 0 9.41964 0 0 0 0 A0A8P0T091 A0A8P0T091_CANLF "Ornithine transcarbamylase, mitochondrial (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)" OTC Canis lupus familiaris (Dog) (Canis familiaris) amino acid biosynthetic process [GO:0008652]; urea cycle [GO:0000050] amino acid binding [GO:0016597]; ornithine carbamoyltransferase activity [GO:0004585] RTRLSTETGFAL 1 3.6 0.99079 -0.26683 0 0 10.5417 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T0B5 A0A8P0T0B5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CSSCYSSSSLWSH;GGSPIGGP;PPTPQTGPANPTGAWGIGT 3 20.6 1.0022 -1.3223 11.8078 0 2.87708 0 0 0 0 0 0 0 2.04569 3.17458 0 0 0 A0A8P0T0C8 A0A8P0T0C8_CANLF Cytohesin 1 interacting protein CYTIP Canis lupus familiaris (Dog) (Canis familiaris) KQLLKFIPGLHRAVEEE;VDKNEHGFPLKRP 2 7.4 0.98895 -0.2238 0 0 0 0 0 0 0 0 0 0 0 3.61965 0 0 7.39746 A0A8P0T0G7 A0A8P0T0G7_CANLF Semaphorin 5B SEMA5B Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399] membrane [GO:0016020] semaphorin receptor binding [GO:0030215] CGTNAFSP;CSSNCGGG;KQQRCSTLEDSSNMS;PLAVTLLPPSLTLLVVH;RCGGRDCLGPAIHIANCSRNGA;YPSPLNKHSFRPE 6 8.4 0.97685 0.046227 0 0 0 0 0 0 3.33128 0 0 0 0 0 0 0 0 A0A8P0T0H1 A0A8P0T0H1_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) CDC14A Canis lupus familiaris (Dog) (Canis familiaris) intracellular non-membrane-bounded organelle [GO:0043232]; membrane-bounded organelle [GO:0043227] phosphoprotein phosphatase activity [GO:0004721] FFDFETFDVDEY;KKLKPKKIFK 2 3.6 0.99123 -0.27443 0 0 8.38202 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T0J6 A0A8P0T0J6_CANLF Nucleoside-diphosphate kinase Canis lupus familiaris (Dog) (Canis familiaris) adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524] GKGTQAPKLAENFCVCHLA;LAENFCVCHLAT;VQRKGEINLKKKLIR 3 19.1 0.80238 0.2078 0 6.7849 0 0 0 0 0 0 0 0 13.1465 13.2828 0 13.0618 8.17093 A0A8P0T0K2 A0A8P0T0K2_CANLF Oxysterol-binding protein OSBPL8 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] membrane [GO:0016020] lipid binding [GO:0008289] DKENDQEHDESD;DSEIERQHFKDQDMYSDK;ENDQEHDESD;IIFLLILLQVII;PVLFPPRID;TDNSEVFWNPTPDIKQ;YYHADFLS 7 8.7 1.003 -1.7274 5.66445 8.85228 0 2.40048 8.86484 0 0 0 4.74841 0 0 5.78707 5.90773 0 7.77689 A0A8P0T0L2 A0A8P0T0L2_CANLF TBC1 domain family member 1 TBC1D1 Canis lupus familiaris (Dog) (Canis familiaris) ALEKNFKEISFCS;GVPRHLRG;LQEELIDSSPLSDNQRMDKLEKTN;QEPPEPAR;YLISPDTK 5 4.9 1.0025 -1.7707 0 0 11.1809 0 0 0 0 0 0 0 0 0 0 5.89787 11.1399 A0A8P0T0P6 A0A8P0T0P6_CANLF DAB2 interacting protein DAB2IP Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] ESLLSPSSAVE;LDQDDSYD;QDDSYDSYE;QSTGKVKDFLT 4 2.9 0.99652 -0.5726 0 0 0 0 0 0 0 0 10.2024 0 0 0 0 0 0 A0A8P0T0S2 A0A8P0T0S2_CANLF Signal transducer and activator of transcription STAT6 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ALVLKRIQIWK;NLPFDQPHPQGLLPCQSQ;PGNCCSAL;RCESLVDIYS 4 5.8 1.0036 -1.9692 0 0 6.03142 0 0 0 0 0 0 0 8.69045 0 11.5481 0 0 A0A8P0T0V1 A0A8P0T0V1_CANLF Transgelin TAGLN2 Canis lupus familiaris (Dog) (Canis familiaris) FQNWLKDGTVLCELINGLYPE;GLGPRGLG;SSGCNGPG;TTASPAAGGGDSSGCNGPGWGG 4 7.6 1.0035 -1.6048 0 0 5.90227 0 0 0 0 9.3077 0 0 0 0 0 0 0 A0A8P0T0V4 A0A8P0T0V4_CANLF Glutathione S-transferase C-terminal domain-containing protein GSTT2B Canis lupus familiaris (Dog) (Canis familiaris) GVGAGAGG;QELEDKFLRDQ;RALQELEDKFLRDQAFLTGQH 3 9.9 0.99372 -0.058368 9.79168 0 0 0 0 0 6.67849 0 0 0 0 0 0 0 0 A0A8P0T0V7 A0A8P0T0V7_CANLF cathepsin X (EC 3.4.18.1) CTSZ Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type endopeptidase activity [GO:0004197] AGIAGSPRASSLGIASWAR;KFNQCGTCT;LLSVQHVLDCAN 3 9.9 0.93375 0.060813 0 0 0 0 0 0 0 6.28548 0 0 0 0 0 0 0 A0A8P0T0W7 A0A8P0T0W7_CANLF Ferritin Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] LHLHAALSP 1 3.7 0.99362 -0.17458 0 0 9.0187 0 0 0 0 0 0 0 0 0 8.95175 0 0 A0A8P0T0X3 A0A8P0T0X3_CANLF "SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)" SPNS3 SPNS2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] KVRTSWLRDMKALIR;LQITAGHILGDAGS 2 4.5 0.98922 -0.26403 0 0 0 0 0 0 0 10.007 0 0 0 0 2.50934 0 0 A0A8P0T0Y3 A0A8P0T0Y3_CANLF PHD finger protein 23 PHF23 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] DTDSEEEEEEEEEEEE;DVCACVCWEGGGGEG;EEEEEEEEEDMVAMVGG;GEAPAPVL;PLRGESAADSDGWDSAP;RIKKSKKRKLKK;TDSEEEEEEEEEEEEEDMVA 7 13.5 0.99089 -0.29736 0 9.07229 6.02653 0 0 0 0 8.07762 0 7.51704 10.2311 8.69749 3.24428 0 0 A0A8P0T0Z2 A0A8P0T0Z2_CANLF "RNA binding protein, mRNA processing factor" RBPMS Canis lupus familiaris (Dog) (Canis familiaris) LTVPALYPSSPEV;TYLNLNFLLKMLSC;VWAPYPLYPAE 3 17.2 0.93756 0.060957 0 0 0 0 0 0 0 10.131 0 0 0 0 0 0 0 A0A8P0T0Z3 A0A8P0T0Z3_CANLF Plexin domain containing 2 PLXDC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TALVVQWDHVHLQDNYN;VGEKEGFIVSE;VGILILVLIIVAAIL;VGLSDAFVVV 4 11 0.95067 0.053874 0 0 4.94411 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T121 A0A8P0T121_CANLF Signal transducing adaptor family member 2 STAP2 Canis lupus familiaris (Dog) (Canis familiaris) signaling adaptor activity [GO:0035591] DKENGESVWVAS 1 3.1 0.99216 -0.14162 0 0 0 0 0 0 0 9.32386 0 0 0 0 0 0 0 A0A8P0T122 A0A8P0T122_CANLF Hyaluronan and proteoglycan link protein 3 HAPLN3 MFGE8 Canis lupus familiaris (Dog) (Canis familiaris) ACCSSSCCSCCPASP;ASWACCSSSCCSCC;CCSSSCCSCCPASPGC;CCSSSCCSCCPASPGCP;CCSSSCCSCCPASPGCPS;SSSCCSCC;SWACCSSSCCSCCP;WACCSSSCCSCC;WACCSSSCCSCCPA;WACCSSSCCSCCPASPGCP 10 4.9 1.0011 -0.62459 5.65827 0 7.74651 5.21595 7.7086 0 1.96912 5.9995 0 0 0 0 6.96924 0 0 A0A8P0T163 A0A8P0T163_CANLF Ankyrin repeat domain containing 11 ANKRD11 Canis lupus familiaris (Dog) (Canis familiaris) LDRSDGGKEVRERA;TKRKLPFTVGA;VGANGEQKDSDTEAMA 3 43.7 0.9862 -0.23219 0 0 0 0 0 0 0 0 0 0 0 0 10.5596 0 0 A0A8P0T189 A0A8P0T189_CANLF HIVEP zinc finger 1 HIVEP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] DDNENEDDDEDS;DEDDNENEDDDED;DGPDEDDNENEDDD;DNENEDDDEDSQ;EALPLTDVL;ERGSPITFQ;GVKRKKIVAENHLKKIPK;KDQKPKKQGKYICEYC;LPSLSMETVNI;PASIIPPPHPLRGS;PDEDDNENEDDDEDSQAESV;QEKSEKFSWPQRSET;QEQQGKLASPRSLGS;SKLPTEKLPPKKKRLRL;SRRGSIDS;SSSSTNIFPVQQLFGIN;TLQSDQSRKPE;TLSKLPTEKLPPKKKRLRLAE;VEDISKTEASSKIDFL;VLSDPVGADHRGTSLALPTK;VVPCIPIGQIRVP 21 8.7 1.0019 -1.2047 8.34837 8.82671 0 0 4.97081 11.0176 9.46838 9.67714 10.216 5.17544 9.4763 0 5.09913 0 10.5628 A0A8P0T1C2 A0A8P0T1C2_CANLF RIPOR family member 3 RIPOR3 Canis lupus familiaris (Dog) (Canis familiaris) EFHISKVDELYEGYCIQC;RKSIHGNSA;VGAPGAAL 3 2.8 0.99281 -0.28642 0 0 0 0 4.53219 0 0 0 0 0 0 0 0 0 0 A0A8P0T1E6 A0A8P0T1E6_CANLF Choline transporter-like protein SLC44A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] organic cation transmembrane transporter activity [GO:0015101] LFVCLPITWI;VIIRYISRVLVWILTILVILGSL 2 4.8 0.98832 -0.22693 0 0 4.37816 0 0 0 0 0 0 0 0 9.46158 0 0 0 A0A8P0T1F1 A0A8P0T1F1_CANLF Kallikrein related peptidase 5 KLK5 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] DSCQGDSGGPVVCNGS 1 5.6 0.96174 0.049233 0 0 0 0 0 0 0 0 0 0 7.52231 0 0 0 0 A0A8P0T1I8 A0A8P0T1I8_CANLF Stabilizer of axonemal microtubules 2 SAXO2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule binding [GO:0008017] LDYVPYQLE;LENERSDYRPYEI;SFQPWEIPP 3 7.8 1.0018 -1.4081 0 0 10.9679 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T1J4 A0A8P0T1J4_CANLF Thyroid hormone receptor beta THRB Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] PESETLTL;TLNGEMAVTRGQLKN 2 4.6 1.0029 -1.3398 0 0 0 0 0 0 0 0 0 9.4764 0 0 0 0 10.436 A0A8P0T1M6 A0A8P0T1M6_CANLF Olfactory receptor OR2AJ7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GGECLLLA 1 2.9 0.98962 -0.26592 0 0 0 0 7.28364 0 0 0 0 0 0 0 0 0 0 A0A8P0T1Q4 A0A8P0T1Q4_CANLF Pirin PIR Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AVLGEGDSVQVENKDPERSHF;SQAILDFRNAK 2 11.6 0.98949 -0.20338 0 0 0 0 0 0 0 0 0 12.1487 0 0 0 7.7117 7.21772 A0A8P0T1R0 A0A8P0T1R0_CANLF Uronyl 2-sulfotransferase UST Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] sulfotransferase activity [GO:0008146] HNKTRLTKNEQV;ILYQRMRYEYEFYHYVKEQFHLL;RCREPGEWALERAKLNV;SPEAVQILYQRMRYEYEFYHYVKE 4 14.7 0.991 -0.14822 0 0 9.62679 0 0 0 0 10.8256 0 5.52713 5.72699 0 7.22439 7.76341 0 A0A8P0T1S2 A0A8P0T1S2_CANLF OXA1L mitochondrial inner membrane protein OXA1L Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] membrane insertase activity [GO:0032977] LFAEAQVQ;LPWWGAIAACT;LSSNMFSLGQVACL 3 8.1 0.98758 -0.36276 0 0 0 0 0 0 0 0 0 0 4.21234 0 0 0 9.71788 A0A8P0T1S4 A0A8P0T1S4_CANLF Sodium- and chloride-dependent glycine transporter 1 (Solute carrier family 6 member 9) SLC6A9 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] plasma membrane [GO:0005886] amino acid:sodium symporter activity [GO:0005283] AIVDEVGNEWIL;WEQGKNTTNPTP 2 3.3 0.94101 0.05044 0 0 0 0 0 0 0 0 0 0 0 8.90415 0 0 0 A0A8P0T1S6 A0A8P0T1S6_CANLF AP-2 complex subunit alpha AP2A2 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] AP-2 adaptor complex [GO:0030122] clathrin adaptor activity [GO:0035615] LEEIVIYTQVVCLLWCH;LSTYIKFVNLFP;LVDVFSDSPSAV;VLVNSNSELIRLIN 4 5.7 0.98646 -0.45092 0 9.71177 0 9.53358 0 0 0 0 0 0 0 0 6.37896 0 0 A0A8P0T1T3 A0A8P0T1T3_CANLF Single stranded DNA binding protein 4 SSBP4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] single-stranded DNA binding [GO:0003697] DMDGLPKSSPGAVAG;ESVSDCVDSPPAAASGRRG;HGGGLGGDA;MSAMEPHHVNGSL 4 10.1 1.0014 -0.69905 9.86983 0 0 11.7667 0 0 0 10.6316 10.931 0 0 0 0 0 0 A0A8P0T1U0 A0A8P0T1U0_CANLF Lipocalin/cytosolic fatty-acid binding domain-containing protein LOC102154510 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] small molecule binding [GO:0036094] LEEVPVEPGFQAQKVE 1 8.7 0.99366 -0.11909 0 0 0 0 9.94568 0 0 0 0 0 0 0 0 0 0 A0A8P0T1V0 A0A8P0T1V0_CANLF Cell division cycle protein 27 homolog CDC27 Canis lupus familiaris (Dog) (Canis familiaris) EVHSEEALFLLATCYYRSGKAYKAY;KSLSLNPFL 2 4.3 0.51744 0.45991 9.29902 0 9.34132 0 0 0 10.4226 0 0 0 0 0 0 0 0 A0A8P0T1W7 A0A8P0T1W7_CANLF Bone morphotic protein 7 BMP7 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] AERSRPGRGHVWRGRSGARLQ;LVEHDKEFFYPR;REAVLFPDPWEPPPPST 3 8.8 0.97845 0.046227 0 0 7.68881 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T1Y5 A0A8P0T1Y5_CANLF "ArfGAP with GTPase domain, ankyrin repeat and PH domain 1" AGAP1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] ELERWERSQSKNRT;FVNSQEWTL;NSEQEENFEFI;QSCESSKNKSRLTSQSE;SLQSCESSKNKSRLTSQ;YHYYSRMANYRNTSEIPLVLVGTQ 6 7.6 0.98164 0.035491 0 8.79438 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T1Z9 A0A8P0T1Z9_CANLF ADAMTS like 3 ADAMTSL3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] CSATCGVG;CSMDPCPS;EEECEGPELP;GAWSECSVSCGEGFHSRQVAC;GVPPAAHL;HYYPENVKP;PGPPLMRPCQMPA;QPNITWLKRGGSLSDN;SCDRDCSDTTHYCM;SLKIHSLAAPD;TCLGGHQEAIAVCLHTQTQQ;VEEWKCMY;VLDGTRCST;VVPDHYCHYYPENVK 14 9.8 0.99682 -5.6201 14.9735 14.7415 0 0 0 9.4149 14.7809 14.8052 14.8299 0 9.22108 8.89954 0 0 0 A0A8P0T239 A0A8P0T239_CANLF T-complex protein 1 subunit zeta Canis lupus familiaris (Dog) (Canis familiaris) chaperonin-containing T-complex [GO:0005832] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] IDLFMVEIME;SETDTSLIRGLVLDHG 2 5.4 0.95616 0.049233 0 0 0 0 0 0 0 0 0 0 5.41268 0 0 0 0 A0A8P0T258 A0A8P0T258_CANLF Pleckstrin and Sec7 domain containing 2 PSD2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of ARF protein signal transduction [GO:0032012] ruffle membrane [GO:0032587] guanyl-nucleotide exchange factor activity [GO:0005085]; phospholipid binding [GO:0005543] EMRGTLVDTE;LGPDSNTLEDSAESRAWRVGGLA;PGGDEEEEEEEEEEEDTD;RYCQCNPEDSTSEDG;SRAWRVGGL;TLDRALRTFLKAFPLMGETQE 6 11.2 0.99194 -0.0058809 0 11.2564 0 8.09424 8.60496 0 0 10.817 4.31484 0 0 0 0 6.12807 0 A0A8P0T261 A0A8P0T261_CANLF ATP binding cassette subfamily G member 4 ABCG4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] TEILTALGL;VELSYSVREGP 2 3.3 0.9865 -0.41956 8.00096 0 9.98542 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T272 A0A8P0T272_CANLF Tetratricopeptide repeat protein 38 TTC38 Canis lupus familiaris (Dog) (Canis familiaris) AEIKDGLEFMQ;SLLMERDALKPGSP 2 5.7 0.99557 -0.19025 0 0 0 3.47508 0 0 0 0 11.0637 0 0 5.15429 11.2592 0 5.1071 A0A8P0T2A1 A0A8P0T2A1_CANLF Interferon-induced transmembrane protein 1 LOC606890 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APWRPRRRPPH;LNIWALVL 2 9.5 0.99097 3.34E-05 0 0 0 0 0 0 0 0 10.2814 0 0 0 0 0 0 A0A8P0T2C1 A0A8P0T2C1_CANLF DNA damage regulated autophagy modulator 1 DRAM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RPCAVRSKGSSCL 1 2.3 0.98421 -0.25302 0 0 0 9.19552 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T2D2 A0A8P0T2D2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;HHISKRKTKSHMILS 2 2.4 0.95245 0.053887 0 0 8.42135 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T2G7 A0A8P0T2G7_CANLF PHD finger protein 12 PHF12 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] PLTPPAAGGLQNHT;TVDNVLYSCD;VGAHPLAS 3 3.2 0.99899 -0.61146 0 0 0 0 0 0 0 7.84568 0 0 0 0 0 0 0 A0A8P0T2J0 A0A8P0T2J0_CANLF Spermatosis associated 17 SPATA17 Canis lupus familiaris (Dog) (Canis familiaris) DKDFQTVLPSFDLFSKY;EREEKKADLEREEKKRDY;RIQRRWRGYRIRKYCFNYFYLKEYL 3 18.1 0.99228 -0.13904 0 0 0 0 0 0 6.22448 0 10.598 0 0 0 0 0 6.57309 A0A8P0T2K4 A0A8P0T2K4_CANLF Pregnancy zone protein-like LOC611458 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] AVKVPDTITE;DLVPVDLSGRSEL;EVELTGHG;EVKGPTQLFIKKKKVRIT;FIKKKKVRITKVNSLIF;GSAGAVYPMVMRHSSPAVE;IFQWQNLRLQ;IKKKKVRITKVNSLIFV;ITVEVKGPTQL;KLQEKPQIQRTE;LYIFTNSKIHKPNFCQLPQ;TSKPQYLVL;TSKPQYLVLVPS;TSKPQYLVLVPSQL;TSKPQYLVLVPSQLY;TSKPQYLVLVPSQLYA;TSKPQYLVLVPSQLYAK;TSKPQYLVLVPSQLYAKVPE;TTSKPQYL;TTSKPQYLVLVPSQL;VEVKGPTQL;YDYYETEEFT 22 10.6 0 5.2381 15.2232 15.2986 14.7704 12.9586 8.01363 13.055 16.1168 16.2193 16.1408 13.4167 13.2527 13.1414 14.771 14.8269 14.852 A0A8P0T2K9 A0A8P0T2K9_CANLF Interleukin-7 receptor subunit alpha IL7R Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cytokine receptor activity [GO:0004896] AELDDYSFSCYS;DYSFSCYSQLEVD;PFQSGILTPNPAAQGQP 3 7.7 0.99481 -0.11721 0 0 0 0 0 0 0 13.2434 0 9.42498 0 0 0 0 3.67582 A0A8P0T2N0 A0A8P0T2N0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AGTGALGIL 1 9.6 1.0035 -0.80421 0 8.15482 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T2P1 A0A8P0T2P1_CANLF COMM domain containing 4 COMMD4 Canis lupus familiaris (Dog) (Canis familiaris) PAHLFPCRTE;VLLAGETRLYLE 2 8.2 0.99448 -0.56102 0 0 0 0 8.68328 0 4.99874 0 0 0 0 0 0 0 0 A0A8P0T2P5 A0A8P0T2P5_CANLF Annexin ANXA2 Canis lupus familiaris (Dog) (Canis familiaris) basement membrane [GO:0005604]; extracellular region [GO:0005576]; membrane [GO:0016020] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; cytoskeletal protein binding [GO:0008092]; phospholipase inhibitor activity [GO:0004859] GLWRRYLWKAS;TNQELQEINRVYKEMYKTDLEKD 2 9.4 0.98448 -0.25342 10.6996 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T2U3 A0A8P0T2U3_CANLF Intraflagellar transport 88 IFT88 Canis lupus familiaris (Dog) (Canis familiaris) DEDDLYSG;RSRREGSASSVFLG;SMGRPMTGAIQDGV 3 4.7 0.29323 0.65235 0 12.5147 10.848 10.7108 0 11.6095 12.6627 0 12.045 10.7977 0 0 0 12.0878 0 A0A8P0T2W3 A0A8P0T2W3_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ULK2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; regulation of autophagy [GO:0010506] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAFYDDDCGATGR;GVLAPPIG;ISSDHSYDMPMGT 3 3.1 1.0037 -1.1044 0 9.85683 0 0 0 0 10.1835 10.2289 15.1149 0 0 0 0 0 0 A0A8P0T2W8 A0A8P0T2W8_CANLF Zinc finger protein 821 ZNF821 Canis lupus familiaris (Dog) (Canis familiaris) ELHQSWRYDRRLPESCFLCHFLWRP;GRYRSLGFRRVYFAPW;SYMCPVCGRALS 3 7.5 1.0037 -0.80405 0 0 0 10.0051 0 0 0 10.1658 0 0 0 0 0 0 0 A0A8P0T2Y4 A0A8P0T2Y4_CANLF CD58 molecule CD58 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ILVVVIIIAIVTVLLI;ILVVVIIIAIVTVLLIKG 2 7 0.97142 0.048313 0 0 0 0 0 6.35456 0 0 0 6.16944 0 0 0 0 0 A0A8P0T2Y6 A0A8P0T2Y6_CANLF STAM binding protein like 1 STAMBPL1 Canis lupus familiaris (Dog) (Canis familiaris) protein K63-linked deubiquitination [GO:0070536] membrane [GO:0016020] K63-linked deubiquitinase activity [GO:0061578]; metal-dependent deubiquitinase activity [GO:0140492] LSSVDLHTHCSYQ;QFLFFEDQL;VQDQHGLLTLGWIHT 3 12.3 0.99235 -0.19307 0 0 0 0 0 0 0 6.34807 0 0 0 0 9.3544 0 0 A0A8P0T2Z6 A0A8P0T2Z6_CANLF NudC domain-containing protein 1 NUDCD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] IRLPEGSSKEDIQVQFLPDH;MKGSGFYVSLEWVTI;QYTLEHMHAFGMYNYLHCDSWYQDS 3 11.1 0.99489 -0.15757 0 0 0 10.67 0 0 0 0 9.44588 0 0 0 0 8.39956 0 A0A8P0T312 A0A8P0T312_CANLF Maltase-glucoamylase MGAM Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] EQAPEVGA;EQVVQEYLELIGR;HTWGMFSR;IIGMMEFSLF;ITPVLDEGAEKVMAYIPD;PVNYKGFP;QEPAQNTHLSR 7 4.5 1.0035 -1.1044 0 0 0 0 0 0 0 0 0 0 7.3361 0 0 0 0 A0A8P0T316 A0A8P0T316_CANLF Transmembrane protein 143 TMEM143 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EVQVTINLDQYIYMQFWALGQR;VDFCTLFHYHHTLARLQALYDPIN;VENWLLAQS 3 12.1 1.002 -1.2836 0 0 11.2538 0 0 0 0 0 0 9.68741 0 0 7.88935 0 0 A0A8P0T322 A0A8P0T322_CANLF 5'-nucleotidase domain containing 1 NT5DC1 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] EQEALPSLEKPGWYSQG;SSNSKTAG;TFDFWKDIVAGIQHNYKMSAFK 3 10.9 1.003 -0.78096 0 0 0 0 0 0 0 9.92512 12.9842 0 0 0 0 0 9.67225 A0A8P0T331 A0A8P0T331_CANLF Ankyrin repeat domain 52 ANKRD52 Canis lupus familiaris (Dog) (Canis familiaris) EVRSLLSQKENINV;QLLLMSGIPSL;VGPYGQGVGGQSL 3 3.5 0.81047 0.21131 4.10434 0 0 0 0 0 9.51361 0 0 0 0 0 0 0 0 A0A8P0T355 A0A8P0T355_CANLF Neurotrophin-3 (NT-3) NTF3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] growth factor activity [GO:0008083]; neurotrophin receptor binding [GO:0005165] DKSSAIDIRGHQVTV;NPVAANRTSRRK;SPRVLLSDSTPLEPP;TYVRALTSE;VIFLAYLRGIQ 5 23.5 0.98511 -0.44777 0 0 0 0 8.33217 0 0 0 0 0 0 8.32341 5.12085 0 0 A0A8P0T388 A0A8P0T388_CANLF Glutathione transferase LOC486404 Canis lupus familiaris (Dog) (Canis familiaris) RVPGVATH;SRLAEWRMRVELA 2 7.2 0.98546 -0.44976 0 0 0 0 0 0 0 0 0 6.3368 0 0 0 0 0 A0A8P0T390 A0A8P0T390_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GAALETWIQLRQEL 1 12.1 0.93722 0.060951 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.08332 A0A8P0T395 A0A8P0T395_CANLF Cilia and flagella associated protein 69 CFAP69 Canis lupus familiaris (Dog) (Canis familiaris) EAGGKIRPSSLRRIPVIGVV;EDYFLEKEG 2 3.3 0.98881 -0.2642 0 5.14139 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T3A1 A0A8P0T3A1_CANLF Vacuolar fusion protein CCZ1 homolog CCZ1 Canis lupus familiaris (Dog) (Canis familiaris) vesicle-mediated transport [GO:0016192] lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658] LGDINSDFTRVDEDE;VDEDEEVI 2 4 1.0048 -1.0505 0 0 0 0 0 0 0 0 0 7.8308 0 0 8.114 0 0 A0A8P0T3C0 A0A8P0T3C0_CANLF Tropomyosin 4 TPM4 RAB8A Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] actin binding [GO:0003779] AGLNSLEAVKRKIQALQ;AKHIAEEADR;EIKLLSDKLKEAETRA;LQKLEEAEKAADESERGM;SEELDHAL 5 27.8 0.77929 0.23151 0 0 0 0 4.56986 0 0 0 9.34527 0 0 0 0 0 0 A0A8P0T3C4 A0A8P0T3C4_CANLF Glucose-6-phosphate isomerase (EC 5.3.1.9) Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] extracellular space [GO:0005615] carbohydrate derivative binding [GO:0097367]; cytokine activity [GO:0005125]; glucose-6-phosphate isomerase activity [GO:0004347] YFQQGDMGSNGKC 1 2.4 0.93905 0.059598 0 0 0 0 0 0 0 0 0 0 7.13422 0 0 0 0 A0A8P0T3C8 A0A8P0T3C8_CANLF Host cell factor C1 HCFC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] GVKPDLPPPPS;PDTVPSHRTLE;PPAASDQG;QPTQVQFVCDRQE;QVVTTVVGGVTKTITL;SAGPLLGPGLAVESGG;SQLVSVGRQLEAHHTHTTNTPTT;TGTTMSVSVGALLPD;TSGTGAPA;TTNTATTSNAGSTQR;VAIKELIVVFGGGN;VGALLPDTVPS;VGWSGPVPRPR;YHCCGRKQNADLEE;YVFGGWVPLVM 15 8.9 1.0024 -1.791 0 9.39478 0 0 9.17463 11.0349 14.8284 0 11.4736 0 11.2945 0 0 0 12.2327 A0A8P0T3E9 A0A8P0T3E9_CANLF Importin-13 IPO13 Canis lupus familiaris (Dog) (Canis familiaris) protein import into nucleus [GO:0006606] cytoplasm [GO:0005737]; nucleus [GO:0005634] small GTPase binding [GO:0031267] LLTSSEEPYSWQHTEAL;RQALHQLYYDPNIENKNLAQ 2 3.9 0.98938 -0.21791 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5266 0 A0A8P0T3F6 A0A8P0T3F6_CANLF Gamma-aminobutyric acid type B receptor subunit 2 GABBR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled GABA receptor activity [GO:0004965] AMNETNFFGVT;CCAYEENMYGSKYQW;DTESFSND;GVTGQVVF;IFKNVKMKKKII;LLLLLLLP;LLLLLLLPLLLPLAP;LLLLLLPL;LLLLLPLL;RLLLLLLL;VKMKKKIIKDQKLLVIV 11 8.4 0.95186 0.053874 0 0 0 0 0 0 0 0 0 0 0 0 0 6.31043 0 A0A8P0T3F7 A0A8P0T3F7_CANLF Family with sequence similarity 120B FAM120B Canis lupus familiaris (Dog) (Canis familiaris) ALCLQGKS;EDTDYLIYDT;GAVRAQHRGLFLV;GVPMCTDPESRQGVPV;ILGEDTDYLIYDT;LLGDGGDGAGTCPTVKEWFVYS;NQEPGTQARRV;PMCTPPKSNQG;RWGRQGSGSH;YGFQNNCLGILGEDTDYL 10 10.1 0.93725 0.059742 0 0 0 0 0 0 0 0 7.59656 0 0 0 0 0 0 A0A8P0T3G6 A0A8P0T3G6_CANLF Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) MED26 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] mediator complex [GO:0016592] TKNEELAKRAKK 1 2.1 0.95364 0.05044 0 0 0 5.13746 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T3G7 A0A8P0T3G7_CANLF von Willebrand factor A domain containing 8 VWA8 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ESSTLGLPDFPLD;GVCQLYMLKEE;INIQEYPIERYEERSQTFTEECAS;LADQGIINYPYSTRE;LTKPAHIESEDS;PPVIGSTTQQWLGP;SYNNDMREILI;VIGSTTQQWLGPEFL;VLFYDNLQHMIV 9 6.5 1.0029 -0.78556 0 0 0 7.79792 6.20934 0 0 0 0 10.1025 8.31148 0 0 10.7434 0 A0A8P0T3H2 A0A8P0T3H2_CANLF Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36) VPS36 Canis lupus familiaris (Dog) (Canis familiaris) protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] ESCRT II complex [GO:0000814]; late endosome membrane [GO:0031902] phosphatidylinositol-3-phosphate binding [GO:0032266]; ubiquitin binding [GO:0043130] MPVSQSLQ;TLLLSTHRLIWRDQKNHECCM;VHLHPPPSNKEP;VPRARRRRRRPGRRRGEGRAPSL 4 13.5 1.0026 -1.1488 5.35251 0 0 0 0 0 0 0 0 10.6758 5.46852 0 7.65471 0 0 A0A8P0T3K7 A0A8P0T3K7_CANLF Synaptotagmin-17 (Synaptotagmin XVII) CLEC19A Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] membrane [GO:0016020] CCQKCYESSCCQSS 1 3 0.93952 0.060769 6.14419 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T3N4 A0A8P0T3N4_CANLF Coiled-coil domain containing 146 CCDC146 Canis lupus familiaris (Dog) (Canis familiaris) organelle [GO:0043226] DLNLRNCLIDKQNYHDELSRKQ;IHKKKKREIHRRKLQN;IKTKDLEIRIHKKKKREIHRRKLQ;QENMRDVVFNLV;QNEYNAVKERESHTQ 5 8.2 0.98734 -0.35198 0 0 0 0 0 0 9.15722 0 9.79331 8.94128 0 0 5.96588 0 11.6006 A0A8P0T3N7 A0A8P0T3N7_CANLF Armadillo like helical domain containing 3 ARMH3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GEEHPIRVVN;HYPPQSDSNSWWLGSSS;IILTCIAEDQY;IINMLMGFDKAELCMKNLMESLDSL;IRAIINHFNPK;LEYLEGKLESLDGEELMKIKDNIN;SGFDIINMLMGFD 7 15.7 0.99661 -0.57869 0 6.50878 0 0 0 9.45061 0 12.2809 0 0 5.10383 0 7.14384 11.4252 0 A0A8P0T3P3 A0A8P0T3P3_CANLF Serine/threonine-protein kinase 40 (EC 2.7.11.1) STK40 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LLLAEEKSSVHEARSWGPK;PSIVQCLARKDGTDDFYQLKI;SIVQCLARK 3 9.3 1.002 -0.99443 0 0 0 0 0 0 0 0 13.0138 0 5.65978 0 0 0 8.10045 A0A8P0T3Q0 A0A8P0T3Q0_CANLF Solute carrier family 15 member 2 (Peptide transporter 2) SLC15A2 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; oligopeptide transport [GO:0006857]; peptide transport [GO:0015833]; protein transport [GO:0015031] apical plasma membrane [GO:0016324]; phagocytic vesicle membrane [GO:0030670] symporter activity [GO:0015293] LHLKTRSQ;LVFSIMGYYYVPIQ;YFSVFYLSINA 3 4.7 1.0014 -0.64174 0 0 0 0 0 0 10.6272 8.90632 0 9.26779 0 0 0 0 0 A0A8P0T3Q1 A0A8P0T3Q1_CANLF Microtubule associated protein 9 MAP9 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281]; spindle assembly [GO:0051225] DEYEKWLEKKERQERIERKQKKRHS;KASVEDQNEELTENHN;MFFLIVFFL 3 6.9 0.9841 -0.24749 7.38707 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T3Q9 A0A8P0T3Q9_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; plasma membrane [GO:0005886] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] AVILRKDMKLA;CALPRYRRFFLPS;DIDDDYYY;DIDDDYYYDDGGGDDEGGVEGD;DISEIQSVCSDVET;DITQLEKEVNVCKQYYQELLKSAER;DLGTITNKCE;ELRDKWDTICGK;FSDEDDFSQ;FSQAATSASVPT;FYDTPLFEDDDHDSL;GSEKAALQSQLNTIKT;GVEGDGKEPWCQDEAADMD;HEEFLQKLESFSHWISEKSKSVKDI;IDELVKSGHKIMAT;ISILRAAHEGL;IVNVQDTE;KFSLENMAQKFKEFQ;KLLEIWIEFGRIKLLQ;KRGLTPKVSPVQLE;LANLEHAFY;LQTVVSESPVHFENLE;LSGLQACEVTA;MVRVGGGWMALDEFLVKNDPCR;QEMKQIKVAQALCEDLSALV;SAETIDQDLNNLKEKW;SLVQEHSALSQQVDE;TIEAYRAAMQTQWSWILQL;TLRPWIDKCQNNLEEIKFC;TQKVEEIDAAILRSQQFD;VDIAGGKLASMSP;VGRDVETLQK;VGRYDDLSKSVNERNEKL;VIADKNNIENLI;YLALLQEMKPPLDNQ;YNLYISEVRNIRL;YRSLENQQNVNVLQ 37 7 0.99677 -5.3338 11.4114 11.9524 11.4543 9.5886 13.6813 9.2764 10.9548 11.9064 11.2303 9.3889 8.4211 9.84687 8.72359 11.2253 10.8231 A0A8P0T3R5 A0A8P0T3R5_CANLF Ferritin Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] QISLELYATYVYLSTSYYLDPDDV 1 16.3 0.97309 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 7.94345 0 A0A8P0T3S4 A0A8P0T3S4_CANLF SRCR domain-containing protein LOC491694 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GAGGGLDQLCLGSVT;VGIWPDAFHC 2 4.8 0.94008 0.070346 9.56892 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T3Z1 A0A8P0T3Z1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) REDRPKAGSRQEEGFGVQPRR 1 15.7 0.9581 0.051119 0 11.5597 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T424 A0A8P0T424_CANLF Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" nuclear cap binding complex [GO:0005846]; nucleus [GO:0005634] RNA cap binding [GO:0000339] QAPHREPDAGLDP 1 8.3 0.99021 -0.26164 0 0 0 0 0 0 0 0 0 0 0 0 9.36162 0 0 A0A8P0T425 A0A8P0T425_CANLF DNA replication licensing factor MCM2 (EC 3.6.4.12) MCM2 Canis lupus familiaris (Dog) (Canis familiaris) DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270] chromosome [GO:0005694]; MCM complex [GO:0042555]; nucleus [GO:0005634] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] KKYIIYAKEKVHP;MAESSESF;REHVLAYFLP;SIAPSIYGHE;VLKKYIIYAKEKVH 5 5.1 1.0021 -0.66764 10.6537 0 0 0 0 0 0 0 0 9.18982 0 9.20728 9.97656 0 0 A0A8P0T433 A0A8P0T433_CANLF Collagen type XIV alpha 1 chain COL14A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] AYSKDKESKPAQ;DVNKISGEMQS;GTPGEQGPPGTPGFP;HPLSVDEGQHKLMWIPVYGGKTEEV;HVFFVDDF;NAFNTKDEVIE;PAIADIVI;PGVPGITGSM;PLTGIFTTEEVPAQQYLEIDEVTTD;PQGPSGQPGYCDPSSC;SEVVTAVGTTLDSFWTEP;TVSGGTTRHCFYG;YRIVYNNADG 13 10.4 1.0031 -1.6293 0 9.08913 10.9897 0 14.9885 11.9072 0 9.08066 0 13.248 13.4111 13.3096 8.89354 0 11.9244 A0A8P0T467 A0A8P0T467_CANLF Butyrophilin subfamily 1 member A1 LOC100856021 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ELRWFRSQFSEAV;EVQVNMGTVAGPVNK;FLAWKQQQEKRRVW;GLGSGPHVFMVGPEDKGIRLTCR;NCFNTGRHYW;VTQNWRKAKLYAAAITLDP 6 17.9 0.95371 0.049463 0 0 0 0 6.86369 7.90195 0 0 0 0 0 0 0 0 0 A0A8P0T480 A0A8P0T480_CANLF Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) RAPGEF2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; small GTPase-mediated signal transduction [GO:0007264] anchoring junction [GO:0070161]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] guanyl-nucleotide exchange factor activity [GO:0005085] DSEDDDDEEDIE;HCRECKNFNS;SEMIVVDYMDEN;YPDGKAEILCMGNS 4 3.1 0.99383 -0.044629 0 0 0 0 0 2.39936 0 3.2714 0 0 14.4174 0 0 0 0 A0A8P0T491 A0A8P0T491_CANLF RRM domain-containing protein MSI2 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] EIRECMVMRDPTTKRSRGFGFVTF;PASQDSGVGNYISAASPQPG;YISAASPQP 3 14.3 1.0037 -1.0412 0 0 0 0 0 0 9.98513 9.26365 0 0 0 0 5.73156 0 0 A0A8P0T499 A0A8P0T499_CANLF hexokinase (EC 2.7.1.1) HK3 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096]; hexose metabolic process [GO:0019318]; intracellular glucose homeostasis [GO:0001678] ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; hexokinase activity [GO:0004396] EEARHVAVLDEDRGRVCVSV;ELTPKESN;TEQGDFVVLELGATGASL;VGASDVELVQYVCAA;VGTMMSCGYE 5 8.1 1.002 -1.365 0 0 0 0 5.94462 8.80938 8.70546 0 0 0 0 0 8.34952 0 0 A0A8P0T4A5 A0A8P0T4A5_CANLF DnaJ homolog subfamily C member 10 DNAJC10 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] oxidoreductase activity [GO:0016491] EDLMNPSVISLTPTTFNE;EIHHGKKI;ELWFVNFYSPGCSHCHD;GVWLNKND;PDKNPNNP;SIDLTPQTFNEKVLQGKNH 6 10.7 1.0031 -2.3266 11.0336 0 0 0 0 0 0 0 10.1114 7.02625 0 0 0 0 9.68119 A0A8P0T4A7 A0A8P0T4A7_CANLF Zinc finger ZZ-type containing 3 ZZZ3 Canis lupus familiaris (Dog) (Canis familiaris) SAGA-type complex [GO:0070461] zinc ion binding [GO:0008270] DCPPEMSLDFCDSCSDCLHETD;EEDDDPDVYYFESD;EKLQKKMIR;IKSDKESVEQRNTVVDND;LQFKKLKKQKLQQM;NCDDCQPD;PVSPVLKRIKRCLRSEAP;VENCERRQTEP;VINCDDCQ;YNYLDPNYFP 10 15.3 1.0028 -2.5292 4.69449 0 6.97797 0 0 2.69751 13.0185 0 6.2535 12.2804 12.2456 0 9.9023 9.81841 13.2501 A0A8P0T4B5 A0A8P0T4B5_CANLF Olfactory receptor OR7A57 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAVLLVGGSLAG;YSLRNKDIKRALKRT 2 8.7 0.93908 0.10431 0 0 0 0 0 0 0 0 0 7.2651 0 0 0 0 7.55075 A0A8P0T4D4 A0A8P0T4D4_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DLEAAFLSRDVDDGSGSP;ELRRLREKHLKEIQ;FQVSVAMDDVQK;GVSVAAPQSAPPEPP;GVYPPSSVQQGVQQTAPPQQ;HYRKSVRSRSRHEKTSRPKLRI;IPVSTALASAVGSV;NTVGGTVN;SGSTVSSIGTLPS;VAAQPSVVPVHSGAHFLPVGQ 10 6.6 0.9854 -0.23555 0 0 0 0 0 0 0 0 9.72458 0 0 0 0 0 0 A0A8P0T4I3 A0A8P0T4I3_CANLF Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK Canis lupus familiaris (Dog) (Canis familiaris) AMP salvage [GO:0044209]; purine ribonucleoside salvage [GO:0006166] nucleus [GO:0005634] adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524] HLDMDKNWTL;KHKELFDE;MHLLEVFCLNWSLTSP;QNSIKVAQWMIQQPYKA 4 17.3 0.95816 0.049233 0 0 0 0 0 0 0 8.19874 0 0 0 0 0 0 0 A0A8P0T4K8 A0A8P0T4K8_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ULK2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; regulation of autophagy [GO:0010506] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AAFYDDDCGATGR;ISSDHSYDMPMGT;IVNGYASAAFY 3 3.2 0.99273 -0.1668 0 0 0 0 0 0 0 0 0 5.76715 0 0 9.80482 0 9.68928 A0A8P0T4K9 A0A8P0T4K9_CANLF Neuron navigator 3 NAV3 Canis lupus familiaris (Dog) (Canis familiaris) neurogenesis [GO:0022008] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EDVGYEGC;ELLPCGYL;GVNGNPQPPGTAG;LETTFDST 4 1.7 1.0022 -1.1333 0 0 0 0 8.819 0 0 0 10.0014 0 0 0 0 0 9.49963 A0A8P0T4N0 A0A8P0T4N0_CANLF KIAA0232 KIAA0232 TBC1D14 Canis lupus familiaris (Dog) (Canis familiaris) ETMWCSRKVRDLWWQ;PLAAPLGPRERRG 2 3.1 0.99063 -0.26777 0 0 0 0 0 0 0 0 11.2412 0 0 0 0 0 0 A0A8P0T4P6 A0A8P0T4P6_CANLF Telomerase associated protein 1 TEP1 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AGELLARYRQALETA;AKPESESSFLVAGADG;DEQKKFEDTYNA;DPAVFHMFLRQQV;EVKLWERPSMQLLG;GAVRCGAV;IPEEETRRNRQLEVC;KLWERPSMQLLGLFQCEG;KSLVSGCDG;LHPQLDRVVLFGNTMYGS;LYASSGPAEEQ;MSRNAKQDKTWT;PEPADQALKDKKLVLMS;PGAQPEEPAPTPEDNS;SEEKMPETELVE;TAHVLIAAQLWK;VLSLENRCLAMLPD 17 8.6 1.0037 -1.0561 0 7.75067 0 6.57068 0 0 6.75782 0 0 0 0 0 0 0 0 A0A8P0T4Q9 A0A8P0T4Q9_CANLF Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) USP48 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197] AADIFYSRYGGGPR;ESVILLKADEPIADYAAMDDVMQGT;FFVEEWRK;GKGTHCSRNAYML 4 5.8 0.9871 -0.35538 0 0 0 0 0 0 0 0 7.20379 7.39386 0 0 0 0 0 A0A8P0T4R1 A0A8P0T4R1_CANLF Sin3A associated protein 130 SAP130 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] GVASTVHLNPMQLMTVDASHARH;TNLEHDVYERLTNLQE 2 4 0.98834 -0.22428 0 0 5.58487 0 0 9.91516 0 0 0 0 0 0 0 0 0 A0A8P0T4R2 A0A8P0T4R2_CANLF Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) PTPN14 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] protein tyrosine phosphatase activity [GO:0004725] ATYGKFKV;QEVSEPLTATKH;QGFLSYLE;QGFLSYLEE;TFSDATMLIHSSESEEEEE 5 4.4 0.98554 -0.43225 0 6.5224 10.6073 0 0 9.00335 0 0 0 11.0125 10.6702 0 10.5493 0 0 A0A8P0T4R7 A0A8P0T4R7_CANLF Ribosomal protein S6 kinase A6 RPS6KA6 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DSPGLPASANAHQ;FEMLTGTLP;VQINGNAAQFAEV;VRTKMERDILV 4 6.7 1.0023 -1.2011 0 0 0 0 9.55182 0 9.9002 0 9.00946 0 0 0 0 0 0 A0A8P0T4R8 A0A8P0T4R8_CANLF Myosin heavy chain 15 MYH15 Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] DEVTQLANDLKAQKTKLWSENGE;DLQLEVDDLLTNVEQMTRAKANSEK;EAAEAQANQYLSKYK;ECSELKKEIDDL;EKAKKAATEAAN;NSLLQSELEELR;SRETLQTANKQL 7 6.1 0.90162 0.12333 0 0 9.27123 7.43488 10.4722 7.71486 4.7823 10.646 0 0 7.31913 4.08882 0 6.7879 0 A0A8P0T4S9 A0A8P0T4S9_CANLF Glutathione S-transferase (EC 2.5.1.18) GSTA4 Canis lupus familiaris (Dog) (Canis familiaris) glutathione transferase activity [GO:0004364] KPKLHYPNGRGRME;YFPVFEKVLRDHGQRFL 2 14.2 0.93194 0.10705 0 0 0 0 0 0 0 0 0 6.03802 3.26449 0 0 0 0 A0A8P0T4T1 A0A8P0T4T1_CANLF SRY-box transcription factor 6 SOX6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AHDEQKKLAASQIE;INGEDEMEMYDDY;MEMYDDYDDDPK;NEMINGEDEMEMYDDYDDDP;NGEDEMEMYDDYDDDPKSDYSSENE;QEARKMREQIQREQQQQQPHGVD;QQQQLLQQQHKI;SREKEEGSDQHVA;VIDLTRPEDAEGGK 9 13.1 1.003 -0.88355 14.7158 0 0 0 0 0 7.54851 7.54967 12.496 0 0 8.11213 9.62877 0 8.30602 A0A8P0T4W3 A0A8P0T4W3_CANLF MAGUK p55 subfamily member 7 MPP7 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] KALFDYNP;KSYAEYAGN;SEIRELLKLLSKPNVKALLSV 3 7.1 0.98374 -0.25658 0 0 0 0 0 6.4081 0 0 0 10.3235 10.1157 0 0 0 8.66131 A0A8P0T4X7 A0A8P0T4X7_CANLF Pleckstrin homology domain containing A8 PLEKHA8 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid transfer activity [GO:0120013] MQRDLSLYLPAMEKQ;QEIIPTFF 2 4.9 1.003 -0.7556 0 0 0 0 0 10.1037 0 0 0 0 0 0 0 0 0 A0A8P0T4X8 A0A8P0T4X8_CANLF DDB1 and CUL4 associated factor 12 DCAF12 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813] HLGTLNKV;RLQNETNYSR;VFASQWLNH;VSGSRDGSMGLWEVTDDVL;VSRKRKAPA 5 13.1 1.0031 -1.9518 0 0 0 0 0 0 0 0 7.93127 10.8003 0 0 0 0 0 A0A8P0T4Z9 A0A8P0T4Z9_CANLF von Willebrand factor A domain containing 5A VWA5A Canis lupus familiaris (Dog) (Canis familiaris) LISLQNADGSWY 1 1.6 0.94489 0.05044 0 0 0 0 8.22279 0 0 0 0 0 0 0 0 0 0 A0A8P0T516 A0A8P0T516_CANLF Tight junction protein 2 TJP2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] EEVGEGSEEQEGA;LVSSITRSSEPVQHEES;PGSPAAAQ;SEGKMEGMDDDP 4 3.6 0.98965 -0.26592 0 0 0 0 0 0 10.0123 0 0 0 0 0 0 0 0 A0A8P0T529 A0A8P0T529_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) FYLVLSLRSICGAY;LQAEDEADYYCSTYDS;RPLGVPDRFSGSRSGSTATLTI;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 39.6 0.94139 0.061093 0 0 0 0 0 0 0 0 0 0 0 0 0 6.98425 0 A0A8P0T546 A0A8P0T546_CANLF Protein phosphatase 1 regulatory subunit 17 PPP1R17 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase inhibitor activity [GO:0004864] LELSEDRLDKL;VHLSLPCWHFCCIH 2 9.3 0.93229 0.09633 6.33185 0 0 0 0 0 0 7.56986 0 0 0 0 0 0 0 A0A8P0T547 A0A8P0T547_CANLF Zinc finger protein 135 ZNF135 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] SLWCSEGDDAEGQGGQCH 1 2.9 0.96631 0.048313 0 0 0 5.98918 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T551 A0A8P0T551_CANLF Transmembrane and coiled-coil domains 3 TMCO3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium:proton antiporter activity [GO:0015386] ETLGEVGVFF;ISREVSVHPH;SIPTWHLSIPPAATH 3 5.1 1.003 -0.85893 0 0 0 0 0 9.12492 10.1464 0 0 0 0 0 0 0 0 A0A8P0T552 A0A8P0T552_CANLF Plasma retinol-binding protein RBP4 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632] DGRSEPNTL;GGGAGGGR;GVASFLQKGNDDH;QDNIVAEFSV 4 12.6 0.98693 -0.3317 0 0 0 0 0 0 0 8.73003 0 0 0 0 0 7.55773 0 A0A8P0T577 A0A8P0T577_CANLF Poly(A) polymerase (EC 2.7.7.19) PAPOLA Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] GVKRTSSPHKEESPKKTKT;NSENLSVDLTYDI;PQQNSTYNVSVSTRMV;YHLMPIITP 4 8.2 1.0012 -0.6434 0 11.2008 0 0 6.97991 5.91538 0 0 0 0 0 7.00169 7.99305 8.08316 10.3187 A0A8P0T581 A0A8P0T581_CANLF Zinc finger protein 565 ZNF565 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DRPYECKD;IPTFEHTSLTLHQNNEIG;RDLYKDVTLE 3 7.7 0.98807 -0.47197 12.8334 0 0 0 0 6.40922 0 0 0 8.51791 0 0 0 0 0 A0A8P0T582 A0A8P0T582_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ASACQGSH 1 12.7 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.19419 A0A8P0T594 A0A8P0T594_CANLF Tetraspanin 4 TSPAN4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SLYGRAGAGDGGDGGDGG;TLLLVLLLEVTVTVLFFAYTDK;VTVTVLFFAYTDKIDRYAQQD 3 17.5 0.86604 0.14443 10.4699 3.11625 6.22172 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T598 A0A8P0T598_CANLF Small nuclear RNA activating complex polypeptide 1 SNAPC1 Canis lupus familiaris (Dog) (Canis familiaris) GLQTDCEALLSRFQETD;MKLITSDV;SYRMKKKI 3 9.6 1.0029 -2.1626 0 8.22018 0 0 0 0 0 0 0 0 0 0 6.15852 0 5.71331 A0A8P0T5A8 A0A8P0T5A8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ESGGDLVKPG;ESGGDLVKPGG;EVQLLESG;EVQLLESGG;EVQLLESGGD;EVQLLESGGDLVKPG;EVQLLESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG 9 22.2 0 7.2841 10.9776 13.1683 12.4207 11.5558 11.1885 10.614 0 11.6435 12.4908 10.6264 11.9495 11.5631 10.1544 10.3726 11.419 A0A8P0T5C7 A0A8P0T5C7_CANLF Protein unc-119 homolog A UNC119 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; protein transport [GO:0015031]; visual perception [GO:0007601] centrosome [GO:0005813]; spindle pole [GO:0000922] lipid binding [GO:0008289] ELSAWAGPLWEWR;EPTLGGVWVWLPSSHPGP 2 18.3 0.99007 -0.20032 0 0 9.03735 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T5D0 A0A8P0T5D0_CANLF X-prolyl aminopeptidase 1 XPNPEP1 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006] CGISYKTFSDEPLEAGM;LCELFNWLE;VDSLTDKELWQVLTSP 3 6.7 0.97592 0.044329 0 0 10.1186 0 0 0 0 0 0 5.87056 0 11.1628 0 0 0 A0A8P0T5D1 A0A8P0T5D1_CANLF Neural cell adhesion molecule 1 NCAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AAAKSPAE;DESKEPIVEVRTEEE;DIQVTVNVPP;FVFRTSAQPTAIPANGS;QESLEFILVQADTPSSPSID;SIHLKVFAKPKITYVENQ;VGILIVIFVLLL;VIVCDVVSSLPPTI;VLSPSAPAGAG 9 11.4 1.0029 -1.7242 3.67276 11.8322 6.19969 8.08454 7.70888 0 8.03419 0 10.716 0 11.3978 6.62882 9.17734 8.52364 0 A0A8P0T5E3 A0A8P0T5E3_CANLF DAB2 interacting protein DAB2IP Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] ESLLSPSSAVE;PASSPSFTPPLS;QSTGKVKDFLT 3 3 0.98988 -0.21741 0 0 0 0 0 0 11.9989 0 0 0 0 0 0 0 0 A0A8P0T5F4 A0A8P0T5F4_CANLF BCL2 associated transcription factor 1 BCLAF1 Canis lupus familiaris (Dog) (Canis familiaris) FKTHHELK;GKNFATTSHRN;KWTHDKYQ 3 3.1 1.0024 -1.8425 0 0 7.01581 0 0 0 0 0 0 0 0 0 13.2267 0 0 A0A8P0T5G4 A0A8P0T5G4_CANLF CD3 epsilon subunit of T-cell receptor complex CD3E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LVSPSSFSSL 1 5.2 0.98555 -0.25858 0 0 0 0 0 9.90162 0 0 0 0 0 0 0 0 0 A0A8P0T5H6 A0A8P0T5H6_CANLF Ephrin-A1 EFNA1 Canis lupus familiaris (Dog) (Canis familiaris) ephrin receptor signaling pathway [GO:0048013] plasma membrane [GO:0005886]; side of membrane [GO:0098552] ephrin receptor binding [GO:0046875] CCSLAAADRHTVFWN 1 8.2 0.98666 -0.23154 0 0 0 0 0 0 0 0 0 0 0 9.21096 0 0 0 A0A8P0T5I9 A0A8P0T5I9_CANLF RNA helicase (EC 3.6.4.13) DDX46 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] EDDDDDEDDPAE;EDDDDDEDDPAEAE;EDDDDDEDDPAEAEKEGNEMEGEEL;LWSDFKDQQ;RSVKGGGG;SLEDDDDDED;SLEDDDDDEDDP 7 4.5 1.0008 -0.92624 3.62539 0 0 0 0 3.97398 0 14.203 0 0 11.6936 4.73525 0 0 8.84912 A0A8P0T5K7 A0A8P0T5K7_CANLF Otopetrin 2 OTOP2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] proton channel activity [GO:0015252] QIFQQGYFYLYPFN;TAICQIFQQGYFYLYPFNI;VMDVFKTGYYSSFFEC 3 5.9 0.99292 -0.15002 0 0 0 0 10.8763 11.0538 10.1595 0 10.398 0 0 0 0 8.2035 0 A0A8P0T5M9 A0A8P0T5M9_CANLF Heteroous nuclear ribonucleoprotein R HNRNPR Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DPLSGQNRGYAFITF;EDYYDDYYGYDYHDYR;GYEDYYDDYYGYDYHDYRGGYEDPY;GYPPDYYGYEDYYDDYYGYDYHDY;IFQTGLVAYVDLDE;TEEILEKSFSEF;YAFITFCGKEAAQEAV;YHDYRGGYEDPYY;YYDDYYGYDYHDYRGGYEDPYYGYD 9 18.1 0.99182 -0.19418 8.53263 4.80162 7.76202 0 0 7.40335 6.00964 0 0 0 7.904 0 8.02076 0 5.36901 A0A8P0T5P1 A0A8P0T5P1_CANLF Presenilin (EC 3.4.23.-) PSEN2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; intracellular signal transduction [GO:0035556]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" EMEEDSYDSFGEPSY;GALQLPYDPEMEEDSYDSFGEPSY;GDFIFYSVLVGKAAATGSGDWNTT;GYPGDELEEEEERGVKLG;HVIMLFVPVTLCMIVVV;LTLLLLAVFKKALPALPI;VLYKYRCYKFIHGW;VLYKYRCYKFIHGWL 8 25.9 0.9942 -0.15211 0 7.46222 0 8.29182 0 8.33526 0 0 0 0 0 0 0 0 0 A0A8P0T5P9 A0A8P0T5P9_CANLF Holocarboxylase synthetase HLCS Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077] LSILSSGFVYEDCSG;VLCQEILDP;YVGSTPQESLGRFQEVRSVLA 3 6.8 0.99441 -0.15622 0 9.1514 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T5Q9 A0A8P0T5Q9_CANLF Palmitoyltransferase (EC 2.3.1.225) ZDHHC15 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] GPTMPTSL;KKFWLIPIGS 2 4.5 1.0031 -0.87205 0 0 6.74672 0 0 0 9.84224 0 0 0 0 0 0 0 0 A0A8P0T5R2 A0A8P0T5R2_CANLF Activator of transcription and developmental regulator AUTS2 AUTS2 Canis lupus familiaris (Dog) (Canis familiaris) ENPKKSSEVKVK;ESKGFHRSS;GVGTLPEHDSQDAGPI;YLRTEFHQHQHQHQ 4 4.1 1.0036 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 7.63008 7.21839 0 A0A8P0T5R6 A0A8P0T5R6_CANLF DnaJ heat shock protein family (Hsp40) member C18 DNAJC18 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] ESHDPCGCCNCM;SHDPCGCCNCMK 2 4 0.94166 0.10088 6.01803 0 0 0 0 0 0 0 6.02299 0 6.25337 0 0 0 0 A0A8P0T5S2 A0A8P0T5S2_CANLF Palmitoyltransferase (EC 2.3.1.225) LOC100687370 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] palmitoyltransferase activity [GO:0016409] DKNGFSLGFS;NESFKRIPSL;PAGGGGAG;RRCILRMDHHCPWVNNC 4 11.7 1.0029 -0.88367 0 0 0 0 4.41474 0 0 0 0 0 0 0 9.87549 0 0 A0A8P0T5U1 A0A8P0T5U1_CANLF Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-) PARP11 Canis lupus familiaris (Dog) (Canis familiaris) NAD+ ADP-ribosyltransferase activity [GO:0003950] AIPMPPHWE;DAAYSSRFCKDD;IYPEYLID;LFGKTMDRSRIK;NEAIPMPPHWE;WNPLMETFQ;YDSCVDDTWD 7 16.1 1.0014 -2.6715 12.8507 0 9.21881 0 12.9549 12.4073 0 0 0 0 9.25835 0 13.2728 0 9.42587 A0A8P0T5V7 A0A8P0T5V7_CANLF Zinc finger protein 354A ZNF354A Canis lupus familiaris (Dog) (Canis familiaris) ALVPTGPG;LRPPADAPL 2 2.3 1.0022 -1.3622 0 10.373 0 0 0 0 0 0 0 0 12.0703 11.9646 0 12.2174 12.2475 A0A8P0T5W4 A0A8P0T5W4_CANLF Ring finger protein 8 RNF8 TBC1D22B Canis lupus familiaris (Dog) (Canis familiaris) DDEEEDFSSPSFQT;EILDEEDFQGLLMLLQ;LDELRKCSWPGVPRE;LDGIQDNYTFAQP;LPLRPIIPLVARISDQN;PLRPIIPLVARI;QDTYRQIFERILFI 7 18.4 0.98735 -0.36557 8.26519 8.60737 7.6708 9.72335 0 0 0 10.0337 0 0 0 0 14.9407 0 0 A0A8P0T5W6 A0A8P0T5W6_CANLF Golgin subfamily A member 5 (Golgin-84) GOLGA5 Canis lupus familiaris (Dog) (Canis familiaris) Golgi organization [GO:0007030] Golgi membrane [GO:0000139] PRPSSQFV;QESYKQIQSEFAA;YKSNLESSKQEL 3 4.8 1.0026 -0.77458 0 0 0 0 0 0 10.897 0 0 0 0 0 0 0 0 A0A8P0T5W7 A0A8P0T5W7_CANLF Ring-box 1 RBX1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] IECQANQASATSEECTVA 1 19.1 0.97224 0.048313 9.24555 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T5X1 A0A8P0T5X1_CANLF Charged multivesicular body protein 7 (Chromatin-modifying protein 7) CHMP7 Canis lupus familiaris (Dog) (Canis familiaris) vacuolar transport [GO:0007034] cytoplasm [GO:0005737]; nuclear envelope [GO:0005635] AEEVYRLYQNSP;SAGLLPPEWEE;TLSNMLGDNKVPAEEVLVAVEL 3 10 0.98996 -0.20116 0 0 0 0 0 9.18965 0 0 9.12714 0 0 0 0 0 0 A0A8P0T5Z9 A0A8P0T5Z9_CANLF Dentin sialophosphoprotein DSPP Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DSDSSDSDSDSDSDSNSN;DSSDSDSSDSDSDSDSDSNSN;GADEDEDKGSGDDEG;GGGDDDSD;KVSEDKESKRQPGMA;NDSESDSEDSDSN;SDSSDSSDSSDSDSTV;SESDSSDSDSDSSN;SKSDSSDSSSSSSK;SNGNDDADSEGDNNSD;SNSSDSSDSNSDSSDSDSSD;SSDSSDSSDSSDSSDSSDSD 12 14.2 0.9624 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 3.99068 0 0 A0A8P0T617 A0A8P0T617_CANLF Glial fibrillary acidic protein GFAP Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] structural molecule activity [GO:0005198] EEGQNLKDEMARHLQEYQDLL;ENNLASYRQEAD;MRDGEVIKESKQ;SQNTAAQSIPETSL 4 11.9 1.0039 -0.81445 0 0 0 8.46728 0 0 0 0 5.92258 0 0 0 0 0 0 A0A8P0T648 A0A8P0T648_CANLF Reversion inducing cysteine rich protein with kazal motifs RECK Canis lupus familiaris (Dog) (Canis familiaris) metalloendopeptidase inhibitor activity [GO:0008191] ESEIVILIIPV;PVCDTNHMEHSNLC;SLYCCDRAEDHACQ 3 4.3 0.9942 -0.16335 10.7214 7.11385 0 2.92353 0 0 0 0 8.18443 0 0 0 0 0 0 A0A8P0T650 A0A8P0T650_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WLPTLFWYVQY 1 7.6 0.98484 -0.24495 0 0 0 0 0 0 0 0 0 0 0 0 0 8.66402 0 A0A8P0T658 A0A8P0T658_CANLF MAGE domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GVSHTRPYKGVNCKTE 1 5.1 0.96213 0.049233 0 0 4.7967 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T665 A0A8P0T665_CANLF Integrin subunit alpha 2b ITGA2B Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] integrin complex [GO:0008305] EAGEHVSFWLQ;GAPTWSCTLGAV;LNEYHQTLHRLHGEQ;NSEAVLLDVPV;VEHTYELH;VLEKTEEAE;VLHGDTHVQEQTRIILD;VYVKNRFNQDKRYCEA 8 9.7 0.98952 -0.51717 0 0 9.71567 0 9.02874 11.1154 0 0 11.7616 0 0 0 10.307 0 0 A0A8P0T666 A0A8P0T666_CANLF Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) IRAK4 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; signal transduction [GO:0007165] cytoplasm [GO:0005737] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] EAVTVQQQQMPLNGKDRT;IETMYSVA;PDSSSPENTSLE;VGTTAYMAPEAL;VTVQQQQM 5 10.9 0.99129 -0.29392 9.96029 9.6634 0 0 6.6737 0 0 0 9.27275 0 9.70729 0 0 0 0 A0A8P0T667 A0A8P0T667_CANLF Thrombospondin 4 THBS4 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; positive regulation of cell division [GO:0051781]; response to unfolded protein [GO:0006986] extracellular region [GO:0005576]; sarcoplasmic reticulum [GO:0016529] calcium ion binding [GO:0005509]; growth factor activity [GO:0008083] CDDDMDGDG;DSNSCFRGVRCTDTRD;ECDDDDDND;ECDDDDDNDGIPD;GDACDEDA;GVGDACDEDADGDGI;GVGDACDSCPDV;GVGDICETDFDQDQVI;NRDGVGDICETDFDQDQVI;TRGCRTERSCRNP;VGDACDEDAD 11 10.3 0.99784 -3.3417 5.18884 0 13.5707 3.59323 0 0 0 4.4142 10.0412 0 9.64631 7.99876 5.07391 0 7.03507 A0A8P0T688 A0A8P0T688_CANLF Synergin gamma SYNRG Canis lupus familiaris (Dog) (Canis familiaris) ADDFGEFNLFG;ASSTKYDVFRQLS;DPVQPRMP;SSNFAVSTLTSYDWSDRDDA;VGEQDDFADFMAFSNSSIS;WIYNESLVP 6 6.5 1.0018 -1.4341 0 0 0 0 0 11.2494 0 0 8.5803 16.7267 3.54572 0 0 5.44198 0 A0A8P0T6B4 A0A8P0T6B4_CANLF Transmembrane anterior posterior transformation 1 TAPT1 Canis lupus familiaris (Dog) (Canis familiaris) cartilage development [GO:0051216]; ossification [GO:0001503] membrane [GO:0016020] DAFLYVFTLLPL;GGGGGGGG;GGGGGGPG;KVQGILSYACVVLF;LAVLLIRVVTSSIKVQ;LVICYFMMHYVDYSMM;MEPGAGSRT;PGGGGGGG;VLFPDVCMVI 9 12.3 1.0025 -1.8535 0 10.3805 8.06792 0 9.48537 0 0 0 0 7.82037 0 0 0 0 8.43496 A0A8P0T6E3 A0A8P0T6E3_CANLF Fibroblast activation protein alpha FAP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] anchoring junction [GO:0070161]; lamellipodium membrane [GO:0031258] serine-type endopeptidase activity [GO:0004252] EDILNGTFTYKTFFPNWIS;FNDTEIPVIA;IVLRPSRVHDSEG;TDERVCLQWLKRIQNVSVLSICDF;VDYLLIHGTA;YTERFMGLPTKN;YYKIFSDKDGYKHI 7 14 1.002 -1.4606 0 10.0087 0 8.10826 8.40998 0 0 9.95389 0 9.09743 10.3353 0 0 15.2582 0 A0A8P0T6E5 A0A8P0T6E5_CANLF DENN domain containing 6B DENND6B Canis lupus familiaris (Dog) (Canis familiaris) recycling endosome [GO:0055037] guanyl-nucleotide exchange factor activity [GO:0005085] FDGWYRQRYKEMAH;KALLKRLLKGLQKKRPWDTQTALLR;LHRDKALLKRLLKGLQKK;VVLQNLLPAPVVLTSV 4 6.8 0.84731 0.19405 0 0 0 0 0 0 9.4441 0 6.70044 0 3.51589 0 5.63407 7.45278 0 A0A8P0T6E6 A0A8P0T6E6_CANLF MHC class I DLA-12 DLA-12 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] ESPPPRVSLLRLP 1 3.6 0.94297 0.059672 0 0 2.24065 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T6F2 A0A8P0T6F2_CANLF Succinyl-CoA:glutarate-CoA transferase SUGCT Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] GSGVAYGP;LFEVFSTLKLIHRHARELLVL 2 8.2 0.98928 -0.21875 8.50764 0 0 7.80761 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T6J6 A0A8P0T6J6_CANLF Chromosome 12 C6orf47 homolog C12H6orf47 Canis lupus familiaris (Dog) (Canis familiaris) APLQYLGSPE;ELRRMDSSSE;LREPSGEEEATDLEDE;RRLGGWLPRPWGH 4 17.1 1.0044 -1.0781 0 0 0 0 0 0 0 10.9465 0 0 7.79474 0 0 12.2499 0 A0A8P0T6J7 A0A8P0T6J7_CANLF Solute carrier organic anion transporter family member SLCO1B3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] GCKSSSGS;HLLKTNEERSQMTNVTNHG;LSYCNSNCNCD;LSYCNSNCNCDEN;NCNCDENDWEPVCGDSG;SNCNCDENDWEPVCGDSGITY;SYCNSNCNCDENDW;SYCNSNCNCDENDWEP;SYCNSNCNCDENDWEPVCGD;SYCNSNCNCDENDWEPVCGDSG;VPLSYCNSNCNCDENDWEPVC;YCNSNCNCDE;YCNSNCNCDENDWE 13 8.5 1.0026 -1.165 0 0 6.37773 7.66477 0 7.37738 5.11977 0 9.91624 9.69818 9.65508 7.48414 9.06434 0 4.82939 A0A8P0T6K5 A0A8P0T6K5_CANLF Strawberry notch homolog 2 SBNO2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] AADWIGLES;ALNQDSAYLDDLSN;EVLDEKDGQLDCFVSAA;GAPDAAADPAALAHQGRDINFKE;IISEASSS;IVRLKTKDKKKQVGIKI;TDDGFYLSYK;VRLKTKDKKKQ;VTAEEAREHWE 9 8 1.0031 -2.4868 5.4679 0 0 0 9.42522 7.35887 4.65065 6.28812 10.8281 0 0 6.88692 0 0 0 A0A8P0T6N1 A0A8P0T6N1_CANLF Thioredoxin domain containing 16 TXNDC16 Canis lupus familiaris (Dog) (Canis familiaris) ENLPIYLRLQKPLLIL;ETLRIKHWNRSNWFKEG;IKHWNRSNWFKEGEKSF;TMEAPLLTEVTEDP;WSDLCTKQNVTEFP 5 8.4 0.9875 -0.40072 0 9.18252 0 0 0 9.20114 0 0 0 0 4.81675 0 0 0 0 A0A8P0T6N5 A0A8P0T6N5_CANLF DET1 partner of COP1 E3 ubiquitin ligase DET1 Canis lupus familiaris (Dog) (Canis familiaris) EVIAVFENTSDELLEL;LANVANHT 2 5 1.0037 -1.0552 0 0 7.22545 0 0 0 0 0 0 7.3856 0 0 0 0 9.82102 A0A8P0T6P4 A0A8P0T6P4_CANLF Retinitis pigmentosa GTPase regulator SRPX Canis lupus familiaris (Dog) (Canis familiaris) EQPESVEFSSG;ETSCSMTDSLDSSPCQ;IDGIPMPPVCFSPSPIP;SDNSLKKDETTK;SEDEEPEDMAEE;SLSNLSSGIVLHQ;VLNDSESTPN 7 8.8 0.9618 0.049233 0 0 0 0 0 0 6.01248 0 0 0 0 0 0 0 0 A0A8P0T6P5 A0A8P0T6P5_CANLF Rhophilin Rho GTPase binding protein 1 RHPN1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DSLTGVPAQQRALAFEKG;LLMAYYNQLCFL;QIGARQDRSCPE;RGPRRRGRCGAPSCPW;SQPWGSAWPE 5 11.7 0.99348 -0.076539 8.92733 0 0 4.00198 5.34252 7.45516 0 0 0 0 0 0 8.83219 0 0 A0A8P0T6R5 A0A8P0T6R5_CANLF Ectodysplasin A receptor EDAR Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330] membrane [GO:0016020] signaling receptor activity [GO:0038023] GVVEGLSPTELPFD 1 3.5 0.98605 -0.2366 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.17557 A0A8P0T6S0 A0A8P0T6S0_CANLF Transmembrane protein 68 TMEM68 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] acyltransferase activity [GO:0016746] GVREALISDETYN;LREESLKNGKPVSFE;VEQLEDYLNFANY 3 12.8 0.99425 -0.1555 0 0 0 5.4665 0 0 0 0 9.53463 0 0 0 0 0 0 A0A8P0T6S3 A0A8P0T6S3_CANLF Transmembrane protein 119 TMEM119 Canis lupus familiaris (Dog) (Canis familiaris) ossification [GO:0001503] membrane [GO:0016020] FLLMFIVCAALITRQ 1 4.5 0.95133 0.053901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.40122 A0A8P0T6S4 A0A8P0T6S4_CANLF protein-serine/threonine phosphatase (EC 3.1.3.16) DUSP13B DUSP13 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine/serine/threonine phosphatase activity [GO:0008138] SDLQHWPESWGM 1 3.8 0.94451 0.05044 0 0 0 0 0 0 0 0 4.26251 0 0 0 0 0 0 A0A8P0T6S8 A0A8P0T6S8_CANLF Eukaryotic translation initiation factor 3 subunit H EIF3H Canis lupus familiaris (Dog) (Canis familiaris) eukaryotic translation initiation factor 3 complex [GO:0005852] metallopeptidase activity [GO:0008237]; translation initiation factor activity [GO:0003743] EVPIVIKNSHLINVLMWEL;TGPAGKGK;VGENPHCLRRICPN 3 11.9 0.9896 -0.20284 0 0 0 0 0 0 0 0 10.4997 0 0 0 0 0 0 A0A8P0T6V4 A0A8P0T6V4_CANLF Meiosis regulator for oocyte development MIOS Canis lupus familiaris (Dog) (Canis familiaris) VGPFLNSLVQEGEWER 1 2 0.96305 0.049233 4.01194 0 0 0 0 0 0 0 0 0 0 0 0 4.30721 0 A0A8P0T6V9 A0A8P0T6V9_CANLF Zinc finger protein 25 LOC479185 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872] CGKSFCQKSILVIHQHIHS;THAREKIHKCNECGK 2 7 0.98454 -0.25298 0 0 0 0 0 8.81423 0 0 0 0 0 0 0 0 0 A0A8P0T6W7 A0A8P0T6W7_CANLF RIC3 acetylcholine receptor chaperone RIC3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] ETCSCCSHE;RKISYPEETYPIYDLSDCIKRRQK;SYPEETYPIYD 3 11.5 0.98312 -0.25572 0 0 0 8.23802 0 0 0 0 0 0 0 0 0 10.5008 0 A0A8P0T6X1 A0A8P0T6X1_CANLF Potassium channel tetramerization domain containing 20 KCTD20 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] PSMNVHRGSE;TDEDSVDWDEDHPP 2 5.4 0.99474 -0.12857 0 0 0 7.0813 0 0 0 0 0 7.95251 8.26045 0 0 0 0 A0A8P0T6Y1 A0A8P0T6Y1_CANLF Neogenin 1 NEO1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IVFECEVTGKP;LLLLLPLL;SDVTEDDAGTYFCIADNGNET;VQETTRMLEDSESSYEPDELT 4 4.4 0.98549 -0.43664 0 0 0 0 0 9.07127 0 0 17.7332 0 0 0 0 0 0 A0A8P0T6Y4 A0A8P0T6Y4_CANLF Regulator of microtubule dynamics protein 3 (Protein FAM82A2) (Protein FAM82C) RMDN3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; spindle pole [GO:0000922] SDRESDDGEDEVSCE 1 3.2 0.95111 0.053874 0 0 0 0 0 0 0 0 0 0 0 3.58316 0 0 0 A0A8P0T6Z9 A0A8P0T6Z9_CANLF Zinc finger protein 112 ZNF112 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FYKPELIFQLER;FYKSEEYGKDYPSPEN;LQGNISHLQKQG 3 4.4 0.98767 -0.48088 0 0 0 0 0 0 0 14.8326 0 0 0 0 7.59612 0 0 A0A8P0T723 A0A8P0T723_CANLF Exportin 5 XPO5 Canis lupus familiaris (Dog) (Canis familiaris) protein export from nucleus [GO:0006611] cytoplasm [GO:0005737] nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267] DEDFNAFF;DEDFNAFFNSSRA;GDDDEMMA;GPSMQQDF;IDWVSMSHITAE;REWPQHWPDML 6 4.5 0.99913 -3.1822 0 9.71373 0 0 3.86602 3.42626 0 0 8.89254 0 9.16815 0 6.17862 6.21148 0 A0A8P0T732 A0A8P0T732_CANLF Solute carrier family 12 member 8 SLC12A8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] chloride:monoatomic cation symporter activity [GO:0015377] CSLRQVPESV;GVKWIIRLQLLLLFLL;IAVDYSYFSLSM;YDFLIAEKKGPNKTPI 4 8.2 0.99098 -0.2722 0 0 0 0 0 0 0 9.36944 0 0 0 0 0 0 0 A0A8P0T738 A0A8P0T738_CANLF Tensin 3 TNS3 Canis lupus familiaris (Dog) (Canis familiaris) cell projection [GO:0042995]; focal adhesion [GO:0005925] metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721] GVDPVYER;GVGPTPHLPDAQRPPPG;LDPQDRKWI;VGSGRAVETGGRS;VIFCALDP 5 3.2 0.99299 -0.14393 12.6296 12.6527 12.6459 0 0 0 0 0 0 12.775 0 0 0 0 0 A0A8P0T750 A0A8P0T750_CANLF Cadherin domain-containing protein LOC608881 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] KKKKKTKKKKKKKH;KKKKKTKKKKKKKHT;KKKKKTKKKKKKKHTPKN;KKKKTKKKKK;KKKKTKKKKKK;KKKKTKKKKKKKHT;KKKKTKKKKKKKHTPKN;KKKKTKKKKKKKHTPKNL;KKKTKKKKKKKHTPKNLLLNF;KTKKKKKKKHTPKNLL;VMKKKKKKTKKKKKKK;VNIPENAPVGTSVT 12 3.6 0.43226 0.52486 5.65375 5.78738 4.20203 4.70797 0 0 9.51229 6.62553 0 0 0 0 0 5.11424 7.10455 A0A8P0T754 A0A8P0T754_CANLF Olfactory receptor OR8K7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CLPLLSLLCSNTHEIE;HLTVATVF;YYLCATQGAFYMIFIISELFILT 3 15 0.9931 -0.15162 0 8.06474 9.82459 0 0 0 0 9.57739 6.20666 0 0 8.79165 0 0 10.1625 A0A8P0T770 A0A8P0T770_CANLF Fer-1 like family member 4 FER1L4 Canis lupus familiaris (Dog) (Canis familiaris) IAPLPLAFGFLL;VWDYDRISANDF;YHPRSPGL 3 14.5 0.94399 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 7.03 0 0 A0A8P0T791 A0A8P0T791_CANLF Amyloid beta protein binding family A member 1 APBA1 Canis lupus familiaris (Dog) (Canis familiaris) GVVIVESGW;HLEGSAEVEVPDEAAG;MPEAEQDLER;VLMARRRMPRS;VLMARRRMPRSNSQENV 5 6.2 1.0013 -0.94125 0 12.5519 0 0 8.25899 0 0 0 0 0 0 0 0 0 0 A0A8P0T794 A0A8P0T794_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) MAST2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DDSSILRRRGLQKELSLPR;HVDSEDEDEASEDGCLE;LLECLEFDPE;QELSLAPAPAAGQV;SPLAHTPS;SYFDTRSERYQ 6 4.8 0.98527 -0.25908 0 0 0 0 0 0 0 12.7811 0 0 0 0 0 0 0 A0A8P0T7B5 A0A8P0T7B5_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EIVMTQSPASL 1 9.4 0.061856 1.0287 0 10.196 10.5227 0 0 0 0 0 0 0 0 10.0992 0 0 0 A0A8P0T7G6 A0A8P0T7G6_CANLF Chromosome 10 C22orf23 homolog C10H22orf23 Canis lupus familiaris (Dog) (Canis familiaris) DLKEQKRKPP;FLYVMMKESKLTNFQ;VGEAAGKGWGWVY 3 12.7 1.0045 -0.81657 0 0 0 0 0 0 10.8144 0 0 0 0 0 9.56575 0 0 A0A8P0T7H7 A0A8P0T7H7_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) FRLYNKAVVIK;MDAFLESHKL;MNEKGEITTNT 3 3.8 0.98111 0.035491 0 0 0 0 0 0 0 0 0 0 0 6.61277 0 0 0 A0A8P0T7I3 A0A8P0T7I3_CANLF Family with sequence similarity 133 member B FAM133B Canis lupus familiaris (Dog) (Canis familiaris) EEREKEKTKKKKKHKKHSKKKKK;EREKEKTKKKKKHKKHSKKKKKKA;SKKKKKKA 3 10.6 0.94223 0.087556 0 0 0 0 0 0 3.29308 4.74077 0 0 0 0 0 0 0 A0A8P0T7L3 A0A8P0T7L3_CANLF Retinitis pigmentosa GTPase regulator SRPX Canis lupus familiaris (Dog) (Canis familiaris) EQPESVEFSSG;FLFKRMSLMSQKSMQ;GKVVQVACGGGHTVVLTDMGL;IDGIPMPPVCFSPSPIP;SDNSLKKDETTK;SEDEEPEDMAEE;SLSNLSSGIVLHQ;VLNDSESTPN 8 11.1 0.99341 -0.06497 0 8.41143 0 0 0 0 0 0 0 0 0 0 0 10.5334 0 A0A8P0T7N3 A0A8P0T7N3_CANLF "Fission, mitochondrial 1" FIS1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266] mitochondrial outer membrane [GO:0005741] APVLGEWRAFRV 1 6.2 0.95358 0.05044 0 0 7.09603 7.00146 0 7.02259 0 0 0 0 0 0 0 0 0 A0A8P0T7N5 A0A8P0T7N5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial fission [GO:0000266] GLVDMAIV 1 8.2 1.0035 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 10.0001 0 0 A0A8P0T7P1 A0A8P0T7P1_CANLF 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) SEM1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248] "nucleus [GO:0005634]; proteasome regulatory particle, lid subcomplex [GO:0008541]" AGLDEDEDAHVWEDN;DEDAHVWEDNWDDDNVE;DEDEDAHVWEDNWDDDNVEDDFSN;EDEDAHVWEDN;PLQISGYK 5 33.7 1.0006 -0.9275 7.00405 7.89178 0 0 0 0 8.00478 0 0 0 0 5.89377 0 0 0 A0A8P0T7U9 A0A8P0T7U9_CANLF FA complementation group I FANCI Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] NLMQHMKLS;PLDYLLCCVQHCLVWYKSRVMPLQQ;SIGVSQVHVDVHS;SLFMCYKKLS;SLKDNDLANLLQ;VESGDLQKEVASE;VSQVHVDVH;YQPKIHHF 8 7.2 1.0021 -2.6229 7.67546 0 0 0 9.78532 7.23936 0 0 0 7.97062 13.2793 0 7.39343 0 0 A0A8P0T7X1 A0A8P0T7X1_CANLF Stromal interaction molecule 2 STIM2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion transport [GO:0006816]; intracellular calcium ion homeostasis [GO:0006874]; regulation of transport [GO:0051049] membrane [GO:0016020] calcium channel regulator activity [GO:0005246]; metal ion binding [GO:0046872] EDKHITVEDLWKRW;IVSQFPGTMA;KDEVAASYLIQAE;VEDLWKRWKTSEVHN 4 5.4 1.0032 -0.97567 0 0 0 10.4873 0 10.257 0 10.572 0 0 0 3.70509 10.2691 0 0 A0A8P0T7Z3 A0A8P0T7Z3_CANLF Rho-associated protein kinase (EC 2.7.11.1) ROCK2 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; positive regulation of centrosome duplication [GO:0010825]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] DSSSIGSGPGDAEADDGFPES;DTPFYADSLVGTYSK;EKVAKELEEEIT;GVEEIKQHPFFKNDQWN;IYESIEEAKSEAM;KELNEMQAQIAEESQIRIELQMTL;LKEECEEKTKLCKELQ;NFDDIEDDKG;QKWVSRLVKKI;SPEVLKSQGGDGYY;VKKIPKKPPA;WVSRLVKKIPKK 12 11.5 0.97699 0.047166 0 0 0 0 5.97347 0 0 0 0 0 0 0 0 0 0 A0A8P0T809 A0A8P0T809_CANLF "TDP-glucose 4,6-dehydratase" TGDS Canis lupus familiaris (Dog) (Canis familiaris) KTIDWYRENFHNWKNAEKALEP;PTDVSRRRDVSRKV 2 10.2 0.98934 -0.26547 0 0 0 0 0 0 9.54081 0 0 0 0 0 0 0 0 A0A8P0T840 A0A8P0T840_CANLF Complement C2 (EC 3.4.21.43) (C3/C5 convertase) C2 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] QERKYYSL 1 1.1 0.99002 -0.26215 0 0 0 0 0 0 0 0 0 0 0 0 0 7.82445 0 A0A8P0T842 A0A8P0T842_CANLF Septin-8 SEPTIN8 Canis lupus familiaris (Dog) (Canis familiaris) septin complex [GO:0031105]; synaptic vesicle membrane [GO:0030672] GTP binding [GO:0005525] AVGFGDQINKDESYRPIV;ELELKEKERELHEKFEH;ETYEAKRKEFLSELQRKEEEMR;FLSELQRKEEEMRQ;GVQAARWRGHPWA;LKSLDLVTM 6 10 0.97396 0.038865 11.8358 0 9.72562 0 0 0 0 10.7891 0 0 0 0 10.1809 0 0 A0A8P0T861 A0A8P0T861_CANLF Scavenger receptor class A member 5 SCARA5 Canis lupus familiaris (Dog) (Canis familiaris) DLQLRLLQA 1 2.5 1.0034 -0.80421 0 0 0 0 0 0 0 0 0 0 9.5857 0 0 0 10.7576 A0A8P0T866 A0A8P0T866_CANLF "La ribonucleoprotein 1, translational regulator" LARP1 Canis lupus familiaris (Dog) (Canis familiaris) mRNA stabilization [GO:0048255] RNA cap binding [GO:0000339] AGRRDFVEAPPPKVNPWT;DEEMEQMDGRK;DETSSVKSDGAGGAR;EKNGDEDCQRGGQ;QEVPPGPPRFQ;QEVPPGPPRFQQVP;SLPDLDSENWI;VENFKKVNMISR;VPREKLVSRPA 9 9.7 1.0033 -1.3817 9.70643 0 0 8.10166 0 0 8.08465 10.3907 11.8187 7.62994 10.8122 0 0 0 0 A0A8P0T8D7 A0A8P0T8D7_CANLF Sad1 and UNC84 domain containing 1 SUN1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CHSHEEKLRELATVLQTLQ;DLKGGNKAATQGNGD;GQCHSHEEKLRELATV;PVLDESLIREQTKVDHFWGLDDD;QKPHSNHCGTVNVG;YGLEDEYQEEGQLL 6 10.2 0.98751 -0.37829 6.09991 0 0 0 8.36151 0 0 0 9.65796 0 0 0 0 0 7.19219 A0A8P0T8E7 A0A8P0T8E7_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" LOC476397 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] SSQEPDVGLNPRSQDHD;YAIYVVNQVHTTAF 2 7.8 0.93443 0.10717 0 0 0 0 0 0 6.68103 0 0 0 0 5.587 0 0 0 A0A8P0T8F9 A0A8P0T8F9_CANLF Netrin receptor UNC5 UNC5A Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] netrin receptor activity [GO:0005042] AVIVYVNGGWSTWTEWSVC;IAVAVCLLLLLLVL;LSVAATKRLKLLLFAPVA;LYVGLIAVAVCLLLLLLVLILV;SLDPPCSRGAD;STDDSSDL;STQNYFRSL;VGEALSVAATKRLKL;VGEALSVAATKRLKLLLFAPV;VGLIAVAVCLLLLLLVLILV;VILAMDHCGE;VSLEQGIVLPCR 12 13.3 1.0031 -1.9118 4.61017 0 0 6.01185 0 0 5.85462 4.2121 3.75136 0 0 0 3.99014 0 10.4626 A0A8P0T8G6 A0A8P0T8G6_CANLF La ribonucleoprotein 4 LARP4 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] NWYITFQSDTDAQQAF;TTQQEKDPVE 2 4 1.001 -0.70573 11.479 10.4801 0 9.72265 0 0 10.5389 0 10.7357 0 10.9765 0 0 0 0 A0A8P0T8L2 A0A8P0T8L2_CANLF Negative elongation factor E NELFE Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] chromosome [GO:0005694]; NELF complex [GO:0032021] RNA binding [GO:0003723] EEEALQKKFNKLKKKKKALLALKK;GPGAGDGPPRSFDWGY;KLKKKKKALLALKKQ;KLKKKKKALLALKKQSSSSTASQ;LKKKKKALLALKKQ 5 13.1 0.99149 -0.27732 0 0 5.79937 0 6.02346 0 10.6737 2.03984 0 0 0 0 0 7.3733 0 A0A8P0T8M6 A0A8P0T8M6_CANLF ATP synthase F1 subunit epsilon ATP5F1E Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) [GO:0000275]" "proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]" TVKIVKVK 1 15.7 1.004 -1.1044 0 0 0 0 0 0 3.97085 0 0 0 0 0 0 0 0 A0A8P0T8N1 A0A8P0T8N1_CANLF NUMB endocytic adaptor protein NUMB Canis lupus familiaris (Dog) (Canis familiaris) QPRTWKPDPSQ 1 1.6 0.98075 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 9.29916 0 A0A8P0T8P0 A0A8P0T8P0_CANLF phosphatidate phosphatase (EC 3.1.3.4) LPIN3 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] KHLGDPNPEQEP;QYQGTCRCRATIYLWKWDDKVVI;SQHLGPSDIYLDDLPSL;TGRKKKLRRRK 4 8.1 0.99722 -0.5951 0 0 11.4375 6.1863 0 0 0 0 5.15717 0 0 0 0 0 10.9732 A0A8P0T8P2 A0A8P0T8P2_CANLF "ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1" ARAP1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] "GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]" ALQPNSGPGARRRH;DDSDYDEAPE;LQELSVQGDSENQVLV;LVSPPLSSPPQPEPE;SLKVYLGVKKKLRPPT;SLMTKKEELLVS;VASLLSEGEELSGEDDDQG;VQLYKNLE 8 7.3 1.0023 -1.3698 0 0 0 0 0 5.38743 11.637 0 0 13.511 0 0 0 7.4937 9.10439 A0A8P0T8U2 A0A8P0T8U2_CANLF RING-type E3 ubiquitin transferase (EC 2.3.2.27) RNF34 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634] metal ion binding [GO:0046872] ANTEEEDDEDDDEDDGDD;ASANTEEEDDEDDDEDDGDDDDEEN;CCDCKKDFCSVCS;DEDDDEDDGDDDDEEN;DEDDDEDDGDDDDEENLEER;DGDDDDEENLEERTPGLS;EDDDEDDGDDDDEENLEERTP;EEDDEDDDEDDGDD;EEDDEDDDEDDGDDDD;EEDDEDDDEDDGDDDDE;EEEDDEDDDEDDGDDDDE;EEEDDEDDDEDDGDDDDEE;EEEDDEDDDEDDGDDDDEENL;SANTEEEDDEDDDEDD;TEEEDDEDDDEDD;TEEEDDEDDDEDDG;TEEEDDEDDDEDDGDDDD;TEEEDDEDDDEDDGDDDDE;TEEEDDEDDDEDDGDDDDEEN 19 12.6 0.68621 0.28435 7.75362 0 8.83463 6.51006 9.43169 10.3808 8.61798 6.32526 6.49578 6.17846 3.86612 3.28985 3.95056 7.3679 6.26386 A0A8P0T8V1 A0A8P0T8V1_CANLF Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) AGBL5 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] DTIYYHREI;SEPEPGPHSAPGLPQTGP;TQKVSHRVLGPVRGSSCSF;TRESSEPEPGPHSAP 4 6 1.0006 -0.63237 9.02589 0 0 0 0 0 0 0 0 0 4.88024 0 0 11.3684 0 A0A8P0T8V3 A0A8P0T8V3_CANLF Dermatan sulfate epimerase DSE Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLYNYLSKTQQEKF;LMNQGYLQEA;RRGGVPASPSSSPP;VGFATAYDFLYNYLSK 4 3.9 0.98823 -0.34182 0 0 9.74302 0 0 8.29815 10.3336 10.3234 0 11.5968 0 0 9.77182 0 10.2554 A0A8P0T8Y3 A0A8P0T8Y3_CANLF Tenascin C TNC Canis lupus familiaris (Dog) (Canis familiaris) AGWDGLRLNWTAADPAYEHFVIQVQ;CSDMSCPNDCHQH;DEGHTGEDCGQ;DTTSYDLRGLE;IVTEVTEETV;LDGQCVCDEGFTGEDC;LENLVSSLREQCTTGA;LKKVIRHKRE;NGMCVCDDGYTGE;QCVCDEGFTGEDCS;SGLVTANVTDTEALAMWQ;TEALAMWQ;TVSWMAPSAQVE;VLSAEASTEEVPDLGNL 14 7.5 0.9744 0.04706 0 0 0 0 0 0 0 0 10.1198 0 0 0 0 0 0 A0A8P0T8Y4 A0A8P0T8Y4_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) FGNGNGLA;GAKMGAGA;GASPAPVSSPGFGVGT 3 10.2 0.99264 -0.55203 0 0 0 0 0 0 8.69544 0 0 0 7.44576 0 8.52881 0 0 A0A8P0T8Y8 A0A8P0T8Y8_CANLF CUGBP Elav-like family member 1 CELF1 Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] RNA binding [GO:0003723] AAASAAQNTPSGTNALTTSSSPL;TLSSLHPM 2 6.5 0.9895 -0.2176 12.1991 0 0 0 6.08977 0 0 0 0 0 0 0 0 0 0 A0A8P0T8Z0 A0A8P0T8Z0_CANLF Transcription elongation regulator 1 TCERG1 Canis lupus familiaris (Dog) (Canis familiaris) RNA polymerase binding [GO:0070063] GDERVFFYNP;TVSSVLPGMAPPIVP 2 2.6 0.9492 0.053909 0 0 0 0 0 0 0 0 0 0 0 0 15.1775 0 0 A0A8P0T8Z1 A0A8P0T8Z1_CANLF BMP/retinoic acid inducible neural specific 2 BRINP2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] LALGLPGWVLAV;LGASLKLLVKKTHRIVRR;LKLLVKKTH;NWTITLGNRWKTFFETVHV;PECNCPDADIQAMEDSL;PVNEGSFPDWERTNVDA;QICLTKNSTLEP 7 13.1 1.0035 -0.87659 0 0 6.72928 0 7.59604 10.6233 0 6.27858 0 0 0 0 0 0 15.1214 A0A8P0T8Z2 A0A8P0T8Z2_CANLF leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) LARS1 Canis lupus familiaris (Dog) (Canis familiaris) leucyl-tRNA aminoacylation [GO:0006429] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] LSKCEACAD;SDECVVALCDQWYLDYGEE;SLVNPQPSNGHFT;TPISEHAVF;TVVYVLPMLTIKEDKGTGV 5 6 1.0024 -1.4453 0 0 0 4.78424 0 0 10.0513 10.1237 0 6.86987 10.7035 0 0 0 8.97172 A0A8P0T903 A0A8P0T903_CANLF Atlastin-1 ATL1 Canis lupus familiaris (Dog) (Canis familiaris) axon [GO:0030424]; Golgi membrane [GO:0000139] GTP binding [GO:0005525]; GTPase activity [GO:0003924] TLITLCTWAYIRYSGE 1 3.1 0.95052 0.053103 0 8.18814 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T921 A0A8P0T921_CANLF Limb development membrane protein 1 like LMBR1L Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; Wnt signaling pathway [GO:0016055] endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] CCPCGSSY;LIFLMPFAYF;VTGKLLVKPRLLE 3 6.8 1.0038 -2.0381 0 0 0 0 0 0 0 0 0 0 4.28548 0 0 0 6.21985 A0A8P0T925 A0A8P0T925_CANLF TBC1 domain family member 31 TBC1D31 Canis lupus familiaris (Dog) (Canis familiaris) EIATTAKDLEMRHLE;FEVVATLI;GLNKKRLQILLKGYGE;IDHDITSQYFF;KVHMRDREIATTAKDLE;NLQKKYPIKSRKLLRVL 6 6.7 1.0021 -0.65036 0 0 6.06206 0 0 10.1719 6.11059 0 10.1092 0 0 0 0 0 0 A0A8P0T926 A0A8P0T926_CANLF Bromodomain and WD repeat domain containing 3 BRWD3 Canis lupus familiaris (Dog) (Canis familiaris) DIEISLYTVEKKKKPSY;IEWQSESSSSDSSSEYSDW;IGREEKEKKETKEKSHLSSSESGEL;QAYIWFAHPQPFL;QKRRRPRYRKRL;RSSSSSLSSSRAPSPKGKQK;TEKARVSHLM;TIRRRLENRFYRRISALMWEVRYIE;VGIKYEVGPPTLCCLKLAFLD 9 9 1.0023 -1.2366 0 9.11855 0 6.92979 3.83228 0 9.53832 11.4665 0 7.27408 0 0 0 10.8096 0 A0A8P0T935 A0A8P0T935_CANLF Solute carrier family 15 member 4 SLC15A4 Canis lupus familiaris (Dog) (Canis familiaris) oligopeptide transport [GO:0006857]; peptide transport [GO:0015833]; protein transport [GO:0015031] membrane [GO:0016020] symporter activity [GO:0015293] AVLILLLIPLKDKLV;LILLLIPLK;SGGGGGRM;VLILLLIPLK 4 3 1.0036 -1.1044 0 0 0 0 0 0 9.64099 0 0 0 0 0 0 0 0 A0A8P0T955 A0A8P0T955_CANLF Wee1-like protein kinase (EC 2.7.10.2) WEE1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cell cycle [GO:0000278] nucleus [GO:0005634] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] CEEEEEEEEEEGSGHST;CSDCEEEEEEE;GEDMEASDYELEDE;LVKHSVLLSASRKSAEQLRIE;PHTPKSLLSKA;WNDSCGEDMEASDYELED 6 11.5 0.99321 -0.062276 0 0 0 6.409 5.43713 0 0 0 6.22764 0 8.15117 5.09732 0 0 0 A0A8P0T973 A0A8P0T973_CANLF Leucine rich repeat and sterile alpha motif containing 1 LRSAM1 Canis lupus familiaris (Dog) (Canis familiaris) LFFRKRKPSEE;RKSLDTEALQ;VHTNHLTSLLP 3 4.6 0.98938 -0.31857 0 0 0 0 0 10.3927 0 14.8379 0 0 0 0 0 0 0 A0A8P0T996 A0A8P0T996_CANLF Alpha and gamma adaptin binding protein AAGAB Canis lupus familiaris (Dog) (Canis familiaris) IQELASLTTGGGDLENFERLFS;LSPEELPEE 2 10.5 1.0027 -0.75474 8.53212 0 0 0 0 0 0 0 0 0 0 0 0 11.2776 0 A0A8P0T9C0 A0A8P0T9C0_CANLF UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3) SLC35A3 MFSD14A Canis lupus familiaris (Dog) (Canis familiaris) Golgi membrane [GO:0000139] pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165] EANEDKTMSTNLKYLSL 1 2.7 0.98439 -0.24348 0 0 0 0 0 9.86692 0 0 0 0 0 0 0 0 0 A0A8P0T9D4 A0A8P0T9D4_CANLF Myosin IC MYO1C Canis lupus familiaris (Dog) (Canis familiaris) myosin complex [GO:0016459]; stereocilium membrane [GO:0060171] actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774] GEATDLTFLEKLEDTI;ILDEECLRPGEATDLTFLEKLEDTI;RNILDTSWPTPP 3 3.7 0.99108 -0.13489 10.7118 0 7.11842 0 9.89856 0 0 0 0 0 0 0 7.59305 0 0 A0A8P0T9D6 A0A8P0T9D6_CANLF tubulin-glutamate carboxypeptidase (EC 3.4.17.24) AGBL1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytosol [GO:0005829] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] DVKEQDDDLETDVNKLT;EALLGRPTWI;EDFEDDADEEVDKDSDSEDVKEQD;MEILFSTTENCLD;QWFYFKVS;SDPVARLLREN 6 7.6 1.003 -2.1282 0 0 0 0 5.21607 0 0 0 0 7.89427 7.98664 4.70576 5.40067 9.11938 0 A0A8P0T9J6 A0A8P0T9J6_CANLF Solute carrier family 2 member 11 SLC2A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] hexose transmembrane transporter activity [GO:0015149] AAERRQPQPGPR;LVNNIFVVAAATLFGFSR;VSMSVQPMYLGESAP 3 8.2 0.94092 0.05044 0 6.01201 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T9K5 A0A8P0T9K5_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL3 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042]; exocytosis [GO:0006887] cytoskeleton [GO:0005856] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] ASKSFGPGHEEDEEEEEYEEEEEE;DEQNVEKNNQ;EDEEEEEYEEE;EDEEEEEYEEEEEEEEEEY;EDEEEEEYEEEEEEEEEEYEEEE;EDEEEEEYEEEEEEEEEEYEEEEEE;EEEEEEYEEEEEEEESSED;EEEYEEEEEEEESSEDQ;GEAGMGKKDDPKL;HEEDEEEEEYEEEEEEEEEEYEEEE;QLSFSEDSDLSSDD 11 4 0.92727 0.095637 0 3.7866 0 0 0 0 0 0 0 5.02715 0 0 0 0 0 A0A8P0T9K8 A0A8P0T9K8_CANLF Kringle-containing protein marking the eye and the nose KREMEN1 Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] membrane [GO:0016020] IVAKILLH;LAQGFAVLYQAVK;LFWNETFQHPY;LLILTVTAIVAKILLHI;SAARSSKV;VGACGGNY;WNETFQHPYNTLKYPNGEG 7 13.6 0.98982 -0.27352 0 0 0 0 0 0 0 0 0 0 0 9.40858 0 0 0 A0A8P0T9M4 A0A8P0T9M4_CANLF Plexin C1 PLXNC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] semaphorin receptor activity [GO:0017154] DTEGRSLATEE;LLWQVPEFNTVAL;LWQVPEFNTVALNVVFE;NILKNPQFVFDIKKTPHIDGCLSV;PLSYIALPRCSLIYPATTW;PRLPRSPPPV;SLPSSRKEMKDVCIQ;SVGPLSYI;TTALCLFRM 9 6.7 1.0031 -1.4963 0 11.4239 8.8827 0 0 0 13.1559 13.0689 0 8.88786 4.9834 9.08497 7.43854 11.8968 0 A0A8P0T9N2 A0A8P0T9N2_CANLF Oxysterol-binding protein OSBP2 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869] lipid binding [GO:0008289] DEDTEYFDAME;DIEIVNHKTKDRC;DSTSFITVITEAKEDSR;EDSEEDEDTEYFDAMEDSTS;EEDEDTEYFDA;LGETFELD;MPLGAIHLEFQ 7 9.9 0.95378 0.050683 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.18359 A0A8P0T9N4 A0A8P0T9N4_CANLF Transmembrane protein 141 TMEM141 Canis lupus familiaris (Dog) (Canis familiaris) LGLSRVDDTVAAKH;LWFQLCPFASY;YWVTRVESHRCSNLWLFL 3 19.8 0.98907 -0.51846 0 0 0 0 0 0 11.5384 0 0 0 0 0 9.91582 0 0 A0A8P0T9N5 A0A8P0T9N5_CANLF Epsilon-sarcoglycan SGCE Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; sarcoglycan complex [GO:0016012]; sarcolemma [GO:0042383] AYIMCCRREGVEKRNMQTPDIQLV;YIQRTPYSDGVLYGSPTAENVG 2 11.6 0.99416 -0.28568 0 0 10.4929 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0T9R1 A0A8P0T9R1_CANLF mRNA-capping enzyme [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] RNGTT Canis lupus familiaris (Dog) (Canis familiaris) 7-methylguanosine mRNA capping [GO:0006370] nucleus [GO:0005634] ATP binding [GO:0005524]; GTP binding [GO:0005525]; mRNA 5'-triphosphate monophosphatase activity [GO:0140818]; mRNA guanylyltransferase activity [GO:0004484]; polynucleotide 5'-phosphatase activity [GO:0004651]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] AGWERGYD;DIEEAPPPPLLPDWC;EDDDEEDEDEDGK;ERSERASAQERARMCILRFQNQ;LPDWCFEDDDEEDEDED;VKMGLLVDL;WCFEDDDEEDE 7 11.2 0.98982 -0.51627 0 0 8.31529 4.78419 3.93376 0 5.70764 13.487 0 0 0 4.80694 9.67405 4.85494 0 A0A8P0T9U8 A0A8P0T9U8_CANLF Mitochondrial translation release factor 1 like MTRF1L Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739] translation release factor activity [GO:0003747] DENEDLRKLAENEIT 1 5.5 0.99305 -0.065113 12.0416 12.0361 0 0 0 0 0 12.2381 0 0 0 11.0723 12.0624 11.6395 0 A0A8P0T9W2 A0A8P0T9W2_CANLF Zinc finger CCCH-type containing 13 ZC3H13 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DRRDERARERDRERERDRERERERE;DTESQKRNTE;DTESQKRNTEE;ERERERERDREREKERELERERARE;GPELPEKGSRG;LVEISNGKNGTLED;RAREREREREREKERDRERERDR;RERERERARERDKDRERQRDWEDKD;SPSHLTEDRQGRW;SSYPERDRYPERDNRDQARDSSFER;SVQGFEDISKAERTESVEG;VEISNGKNGTLEDSQK;YVHELSLE 13 11.3 0.97921 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.81578 A0A8P0T9Z9 A0A8P0T9Z9_CANLF BTB domain containing 7 BTBD7 Canis lupus familiaris (Dog) (Canis familiaris) morphogenesis of a branching epithelium [GO:0061138] EFGLADAAAELLQNP;EGATVSYEIQI;GAGGGGGG;GGGGGGGG;RMVRMSNVP;SLGRGAQQNTDLER 6 7.6 1.0011 -0.63779 0 7.83813 8.79035 0 8.33593 0 0 0 0 0 0 0 0 0 7.76155 A0A8P0TA08 A0A8P0TA08_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] immunoglobulin complex [GO:0019814] ESGGDLVKPG;ESGGDLVKPGG;EVQLVESG;EVQLVESGG;EVQLVESGGD;EVQLVESGGDL;EVQLVESGGDLVK;EVQLVESGGDLVKP;EVQLVESGGDLVKPG;EVQLVESGGDLVKPGG;EVQLVESGGDLVKPGGS;EVQLVESGGDLVKPGGSL;EVQLVESGGDLVKPGGSLR;EVQLVESGGDLVKPGGSLRL;EVQLVESGGDLVKPGGSLRLS;LLFLVAILKGVQGEVQL;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;QLVESGGDLVKPG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG;VQLVESGGDLVKPG 25 22.8 0.97666 0.046227 0 0 0 0 0 0 0 0 0 6.38161 0 0 0 0 3.9014 A0A8P0TA09 A0A8P0TA09_CANLF "FYVE, RhoGEF and PH domain containing 6" FGD6 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] LGFTVTQVKDE;MEDNDANVYEVE;NGDRQHLVNP;VLHSIPSGRKQKKIP 4 3.6 0.98815 -0.47165 0 6.58049 0 0 0 8.71922 6.09906 0 7.19032 0 0 0 0 0 0 A0A8P0TA19 A0A8P0TA19_CANLF Muscular LMNA interacting protein MLIP Canis lupus familiaris (Dog) (Canis familiaris) ANLSSPSSTVSESQLTKPG;LSESNEYLTLNAGSQ;LSQACSLSPT 3 5.4 0.98678 -0.45844 0 11.1372 0 0 0 0 0 9.11241 0 6.23354 0 0 0 0 0 A0A8P0TA27 A0A8P0TA27_CANLF FIP-RBD domain-containing protein RAB11FIP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] small GTPase binding [GO:0031267] DFQSRWEDDDNEDESSSAS;DNLLVRVMEETPN;DTHHTSTA;GTATIISENLINETMMKKYNPS;KKSKIKTLFSKSNLQ;LLSLVTGK;LSWTQLWYT;SADPKQLNQSNFSL;TEPEPDRQL 9 9.8 0.99742 -3.8514 7.1416 0 0 11.4003 7.35518 0 0 10.7387 9.57052 4.8473 0 0 0 9.45726 0 A0A8P0TA28 A0A8P0TA28_CANLF ER lumen protein-retaining receptor KDELR1 Canis lupus familiaris (Dog) (Canis familiaris) protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031] COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] ER retention sequence binding [GO:0046923] AAFSLSSPQ;LPLPSGAVRTDRRTQAAGDA;LVNHDFTPLEILWTFSI;SQVLFAVVF 4 14.9 0.9981 -0.60237 9.71768 0 0 0 0 9.00933 0 0 0 0 0 0 0 11.3684 10.6971 A0A8P0TA40 A0A8P0TA40_CANLF Lysosomal associated membrane protein family member 5 LAMP5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] EKTHFKDAVSAGKHTANSHRLS;FSEEHKCPVD 2 13.6 0.98335 -0.2524 0 0 0 0 0 0 0 10.4074 0 0 0 0 0 0 0 A0A8P0TA60 A0A8P0TA60_CANLF Peroxisomal targeting signal 1 receptor (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) PEX5 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] peroxisomal matrix [GO:0005782] SALRKCLELKPD;VSFTNESLQRQACETLRDWLRYTP 2 6.1 0.93457 0.091743 0 9.19906 0 0 0 0 0 0 0 0 0 0 0 0 9.83251 A0A8P0TA90 A0A8P0TA90_CANLF Methenyltetrahydrofolate synthetase domain containing Canis lupus familiaris (Dog) (Canis familiaris) SVSKQDIRQQIW 1 14.5 0.953 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 8.64839 0 0 A0A8P0TA95 A0A8P0TA95_CANLF Gamma-aminobutyric acid type B receptor subunit 2 GABBR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled GABA receptor activity [GO:0004965] AMNETNFFGVT;DTESFSND;GVTGQVVF;IFKNVKMKKKII;LLLLLLLP;LLLLLLLPLLLPLAP;LLLLLLPL;LLLLLPLL;RLLLLLLL;VFCCTPQQYEREY;VKMKKKIIKDQKLLVIV 11 8.5 1.0031 -2.2911 0 0 0 0 0 0 8.43605 0 0 0 0 11.1731 0 0 10.4852 A0A8P0TAA3 A0A8P0TAA3_CANLF Zinc finger protein 513 ZNF513 Canis lupus familiaris (Dog) (Canis familiaris) CGGPTGEGPCCGAGGPGGGPPLP;DESGGGRPLSAESE;EAGGGASGGPQGP;GQDLEFEEEEEEEEEEG;RHMKTHSGEKP 5 14.4 0.98697 -0.40867 0 0 0 0 0 9.16857 0 4.19881 6.62328 0 9.65408 9.8437 0 7.19486 0 A0A8P0TAA4 A0A8P0TAA4_CANLF Ubiquitin like modifier activating enzyme 6 UBA6 Canis lupus familiaris (Dog) (Canis familiaris) protein modification by small protein conjugation [GO:0032446] ubiquitin-like modifier activating enzyme activity [GO:0008641] ADIVHWLSW;EAIYSDEF;ISNITQAN;SLYTSLHGSPTFSSSP 5 4.4 0.99212 -0.03389 0 0 0 0 0 0 0 0 0 0 0 0 0 8.73971 0 A0A8P0TAB5 A0A8P0TAB5_CANLF Bridge-like lipid transfer protein family member 3B BLTP3B Canis lupus familiaris (Dog) (Canis familiaris) EDSHLLSFDNDV;GEIGSETSDKKD;IHSKSSPEITLR;LTGRLKRKKLLKEYY;LYSQLNALQFTVD;NASFELSQLRIYS;VGSPPKSPTH;VNGEIDIRGEDMEICL;VYIEFTEYYYPDG;YSQLNALQFTVD 10 8.4 0.98602 -0.42164 11.3327 11.5568 12.5668 0 0 0 10.6008 10.7474 11.0591 9.82448 0 0 11.1347 11.5737 14.307 A0A8P0TAB7 A0A8P0TAB7_CANLF Zinc finger C3H1-type containing ZFC3H1 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] DENLTVEERVEVCV;DLTGTCNDDDC;EPEFSLPQPSLHDLTQ;FADEEEEEE;GGGGGGGA;GGGGGGGG;IFFYLSCVPKTQHSK;LFRYLLNIPGPL;PIKYAFQPENRI;QREVHRLYQRALQK;RGGASGGG;RLCKGNFDDEMFNYQVPYLWLIYCL;SSSGGGGG;SSSSGGGG;TLNDSDDSES 15 8.3 1.0022 -1.4515 9.51033 0 4.35163 0 10.1619 8.50835 0 0 0 5.97945 0 10.1537 0 0 11.5851 A0A8P0TAC3 A0A8P0TAC3_CANLF WD repeat-containing protein 70 WDR70 Canis lupus familiaris (Dog) (Canis familiaris) ASFKAFRSLQPCECHQIKSLQYS;EDDDDDGDSEEE;EDDDDDGDSEEEE;EVEEDDDDDGDSEEEE;TFDLEAMFEQTR;TMGFTGFG;TVSALGLDP;VEEDDDDDGDSEEE 8 17.5 0.99141 -0.54674 0 6.49661 2.42342 0 0 0 0 0 7.62629 0 0 11.8916 0 0 0 A0A8P0TAD8 A0A8P0TAD8_CANLF Ring finger protein 38 RNF38 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] GAQAGGAC;NPNNHQSEQTLQ;NPNNHQSEQTLQIVLA;NPNNHQSEQTLQIVLAQSAELM;PGQFVPFQTQ;QEVSFGVPYPPFMPRRL;QHLPVCSVPPPMLQ;STNLVWVFLITCIYGLFI 8 15.2 1.0025 -1.7866 0 8.74177 9.53013 0 10.0037 0 9.68538 0 10.5943 0 0 0 8.46854 6.09221 0 A0A8P0TAF5 A0A8P0TAF5_CANLF Olfactory receptor OR7A55 OR7A58 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LIILAVSCDPHLHTPMYFF 1 6.1 0.95177 0.04981 0 0 0 0 0 0 0 0 0 0 0 0 0 9.4818 0 A0A8P0TAG3 A0A8P0TAG3_CANLF DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) NEIL2 Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284] damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; lyase activity [GO:0016829]; zinc ion binding [GO:0008270] LSPRHLEALVD 1 3.3 0.98531 -0.25939 0 0 0 0 0 0 0 0 0 0 0 0 0 10.9587 0 A0A8P0TAH2 A0A8P0TAH2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] LFLEHAHNLAD;SVPLKDLFLEHAHNLAD 2 11.5 0.98793 -0.49343 0 0 9.82753 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TAH3 A0A8P0TAH3_CANLF Microtubule-associated protein RP/EB family member 2 MAPRE2 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] microtubule [GO:0005874] microtubule binding [GO:0008017] RYHQSTHCC;SHHANSPTAGAAKSSPASK;TAGAAKSS;VSLNYTKVEQLC;YDPVEARQGQDAI 5 16.8 1.0034 -0.80421 0 0 0 0 0 0 0 0 7.71761 0 0 0 0 0 0 A0A8P0TAH4 A0A8P0TAH4_CANLF DnaJ heat shock protein family (Hsp40) member B1 DNAJB1 Canis lupus familiaris (Dog) (Canis familiaris) protein folding [GO:0006457] unfolded protein binding [GO:0051082] DVIYPARISLREALCGC;GANGTSFSYTFHGDPHAMF;GEEGMDIDDPFSSFPMGMGGFT;KGGGPSGG 4 19.4 1.0018 -0.96171 0 0 4.58304 0 0 0 0 10.3544 0 9.53138 0 0 0 9.74557 0 A0A8P0TAI7 A0A8P0TAI7_CANLF Ceramide synthase 3 CERS3 Canis lupus familiaris (Dog) (Canis familiaris) ceramide biosynthetic process [GO:0046513] endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634] DNA binding [GO:0003677]; sphingosine N-acyltransferase activity [GO:0050291] ELSWKEFLHKENRKH;VAGIVFLYDPLLPSQYWYYILEM;YCTLILPLHYLEP 3 13.7 0.98798 -0.22769 0 0 12.3944 0 7.22709 7.26969 0 0 0 7.20447 0 0 0 0 0 A0A8P0TAJ7 A0A8P0TAJ7_CANLF Tyrosine-protein kinase (EC 2.7.10.2) FER Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715] FIDVHRLKTLAE;GILLWETFSLGVCPYPGM;GVYSSSGL;ISDFGMSRQEDGGV;IVNVHKEIQMSVE;LDAASGMSYL 6 9.3 1.0046 -2.0088 0 10.6598 7.55205 0 0 0 8.88114 7.92719 0 0 0 0 0 0 0 A0A8P0TAK7 A0A8P0TAK7_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) USP11 CDK16 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] ATP binding [GO:0005524]; cysteine-type deubiquitinase activity [GO:0004843]; protein kinase activity [GO:0004672] ETLEKENPWFCPTCKQ;EVPTRAAPGEP;PEMKKRYYDEVEAEGY;RLVVPKKGKI;SSPLEWGAPLEIVHED 5 5.2 1.0021 -0.65528 0 0 0 0 8.93999 4.98755 11.6981 0 0 0 0 0 0 0 0 A0A8P0TAP1 A0A8P0TAP1_CANLF Leucine rich melanocyte differentiation associated LRMDA Canis lupus familiaris (Dog) (Canis familiaris) LSTEDLFLCLE;VLHKLPNLKFLDARKVTRQEREEAL 2 19.9 0.98506 -0.25916 0 0 0 5.07485 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TAQ0 A0A8P0TAQ0_CANLF Transient receptor potential cation channel subfamily M member 2 TRPM2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] monoatomic ion channel activity [GO:0005216] GIATWGTVHNREGLVHPSVS;HIFTVSKTLGPKIIIVKRM;KVNIVRRRQLLTVF;LFIKRVVLKIPAKRHKQL 4 7.1 0.91611 0.11909 0 0 0 0 0 8.4744 0 0 0 0 0 0 0 0 3.74104 A0A8P0TAQ1 A0A8P0TAQ1_CANLF Olfactory receptor OR4C1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLTISLSSTLSAPMYFFL 1 5.9 0.96125 0.04879 0 0 0 0 0 0 0 0 0 0 0 5.49943 0 0 0 A0A8P0TAS5 A0A8P0TAS5_CANLF Calcium uniporter protein MCUB Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial calcium ion homeostasis [GO:0051560] mitochondrial inner membrane [GO:0005743] calcium channel activity [GO:0005262]; uniporter activity [GO:0015292] ILLMNDFKLVINKVPYD;KREHLLLEKID;LVHRLFTALHLEEF 3 13.8 0.98774 -0.39945 0 0 0 0 0 0 0 0 5.49394 0 0 0 9.0404 10.8299 0 A0A8P0TAV6 A0A8P0TAV6_CANLF Synapse defective Rho GTPase homolog 1 SYDE1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AEPLLRKTFSRLRGREKL;DEDEEAGEPAG;FSRLRGREKL;KMKKLPDLRRRLSLRGTR 4 6.8 0.99251 -0.14351 0 0 3.89579 0 0 0 0 0 9.0964 10.6417 0 5.55219 0 0 0 A0A8P0TAX2 A0A8P0TAX2_CANLF RAD1 checkpoint DNA exonuclease RAD1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077] nucleus [GO:0005634] VNRYKISLLKPSTKALVL 1 6.9 0.9663 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 6.10896 0 0 A0A8P0TAY0 A0A8P0TAY0_CANLF Ubiquitin conjugating enzyme E2 A UBE2A Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] VVLSRRQTDPRLRRG 1 6.9 0.95268 0.053874 0 0 0 0 0 4.49461 0 0 0 0 0 0 0 0 0 A0A8P0TAY7 A0A8P0TAY7_CANLF CLPTM1 regulator of GABA type A receptor forward trafficking CLPTM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAQEADGAGSAV;LDIPQSVQQNGSIYIHVYFTKSGF;PLLGCYAVYSL;PLRVSFCPLSL;SMLYGFLLTFGFITMTPQ;WQLYAAQSTKSPW 6 13.9 0.99288 -0.55484 10.5945 0 0 10.4271 0 0 8.36032 0 6.00493 11.4887 0 11.5993 7.22843 0 0 A0A8P0TB04 A0A8P0TB04_CANLF Glial fibrillary acidic protein GFAP Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882] EEGQNLKDEMARHLQEYQDLL;ENNLASYRQEAD;QTLEESLNWHIEGSQLL 3 9.7 0.99454 -0.1544 0 0 0 0 0 0 10.6224 0 0 0 0 0 0 0 0 A0A8P0TB22 A0A8P0TB22_CANLF Membrane spanning 4-domains A7 MS4A7 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IIQILCCLLIS;NVVSSLAAGVG 2 10 0.98604 -0.41492 0 0 0 12.3881 0 0 0 0 9.68471 0 0 0 0 0 0 A0A8P0TB23 A0A8P0TB23_CANLF "Histone-lysine N-methyltransferase, H3 lysine-79 specific" DOT1L Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; heterochromatin formation [GO:0031507]; methylation [GO:0032259] nucleus [GO:0005634] histone H3K79 methyltransferase activity [GO:0031151] AEPSAFDEVSGSGSLFASMGSCSST;EKQRHCLELQISI;GVAGGAVGG;HHDAAHEIIETIRWVCEEIPDL;HSPFYQLPPSVQ;QLREQTEQLQKDNRELRS 6 6.6 1.0029 -0.78209 5.72885 5.32686 0 0 0 0 11.6956 10.2177 10.507 7.20398 0 0 0 0 0 A0A8P0TB34 A0A8P0TB34_CANLF Ubiquitin-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PHWATCMEPA 1 4.1 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 4.15809 0 0 0 A0A8P0TB39 A0A8P0TB39_CANLF Copine 6 CPNE6 Canis lupus familiaris (Dog) (Canis familiaris) calcium-dependent phospholipid binding [GO:0005544] ANPGQEMQWDCINPK;PSALAKCVLA 2 4.7 0.98745 -0.46596 0 0 0 0 0 0 0 0 0 10.1833 7.88686 0 0 0 0 A0A8P0TB55 A0A8P0TB55_CANLF WD repeat domain 27 WDR27 Canis lupus familiaris (Dog) (Canis familiaris) LHDLPHPLYT;RVSLKKKSESFSRRVESRLCSL;VLHYRDFRSL 3 5.3 0.99957 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 4.15283 0 A0A8P0TB57 A0A8P0TB57_CANLF NEK6-subfamily protein kinase (EC 2.7.11.34) NEK7 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; spindle pole [GO:0000922] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] DNELNIVLELADA;ERTVWKYFVQLC;GVPVALKKI;MHRDIKPA;SEELRQLVNMCIN 5 18.4 1.0022 -1.2233 0 12.8133 0 0 0 0 2.99735 0 0 0 0 0 0 0 9.70257 A0A8P0TB62 A0A8P0TB62_CANLF "ETS proto-onco 1, transcription factor" ETS1 Canis lupus familiaris (Dog) (Canis familiaris) sequence-specific DNA binding [GO:0043565] GPWHRAGETAR;VLSVVPASGS 2 4.5 0.98899 -0.52448 9.9242 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TB65 A0A8P0TB65_CANLF Tetraspanin TSPAN5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NNIRAYRDDIDLQNLIDFTQEY;YRDDIDLQNLIDFTQEY 2 9.6 0.99012 -0.5161 8.73166 0 0 0 0 0 9.8558 0 0 0 0 0 0 0 0 A0A8P0TB66 A0A8P0TB66_CANLF Transmembrane protein 98 TMEM98 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] VGDIIVVAKRISPRVD;VGRRGPFLRVTLQTRP 2 15.4 0.99214 -0.54319 0 0 8.5988 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TB80 A0A8P0TB80_CANLF NADH dehydrogenase subunit 1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AADPFTLFFLAEY;LVSGFNVEYAADPFTLFFLAEYANI 2 31.6 0.99359 -0.27949 0 0 0 0 0 0 7.90388 0 0 0 0 0 0 0 0 A0A8P0TB95 A0A8P0TB95_CANLF ferroxidase (EC 1.16.3.1) CP Canis lupus familiaris (Dog) (Canis familiaris) copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] AAVEVEWDYSPSREWE;CLSKMYYSAVDPTKDIFTGLIGP;ELHLLQEQNVSN;LDNEKEKNID;LGIFLFLYSN;LVMQPDTPGTF;SVHFHGHS;TVLSNRDTQFG;TVPEEVGPTYKD;VEVEWDYSPSREW 10 10.6 1.0029 -2.1992 0 0 0 9.44999 0 0 0 0 3.53032 0 8.93074 0 10.6697 0 9.38909 A0A8P0TBA6 A0A8P0TBA6_CANLF Apoptosis inducing factor mitochondria associated 1 AIFM1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] oxidoreductase activity [GO:0016491]; protein dimerization activity [GO:0046983] SESETESE;VLTGKKVVHLD 2 3.3 1.003 -1.3394 0 0 0 0 14.9492 0 0 0 0 4.45838 0 0 0 0 0 A0A8P0TBB2 A0A8P0TBB2_CANLF Tumor protein p53 inducible protein 13 TP53I13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DTVAAVLKRRLLLPPRRLKRSR;EPAWAAHLLKRRRRRRRRQRKKAWF;HLLKRRRRRRRRQRKKA;LKRRLLLPP;LLKRRRRRRRRQRKK;VLKRRLLLPP;VLKRRLLLPPRRLKR 7 12 1.0027 -1.1795 0 6.43248 0 0 0 5.79304 0 0 5.37938 0 4.13759 0 5.13545 5.72326 6.3085 A0A8P0TBC1 A0A8P0TBC1_CANLF Syndecan SDC1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] AEDGVSTQLPAGE;DIDSSTSILLTREGPEG;EPDQRNQP;VGFMLYRMK;VLVAEAEPGFTDREKET 5 21.9 1.0038 -1.6742 8.97036 9.52601 0 8.50032 0 0 9.34152 0 0 0 9.28047 9.61548 0 11.0254 9.38087 A0A8P0TBE0 A0A8P0TBE0_CANLF Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] AAPIIDVL 1 7 0.9872 -0.26018 0 0 0 0 0 0 0 0 13.6305 0 0 0 0 0 0 A0A8P0TBF4 A0A8P0TBF4_CANLF Calpain 14 CAPN14 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198] GVTCKHGPE 1 1.3 1.0038 -0.80421 0 0 5.42694 0 0 0 0 0 0 0 0 0 0 0 5.88582 A0A8P0TBH2 A0A8P0TBH2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALRRVLARKLR;LLGLSNNPQIQ;TETCLLSVMAYDRF;TTMAVLGLGTFVLLLGSYTRII 4 18.7 0.99362 -0.071172 0 0 11.0051 0 0 0 0 0 0 0 0 0 9.04067 4.00675 0 A0A8P0TBI0 A0A8P0TBI0_CANLF Maltase-glucoamylase MGAM Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] apical plasma membrane [GO:0016324] alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246] DVVKTNAGF;ENMLQFKIFDPTNKRY;EQVVQEYLELIGR;ETEHTAFRRDMNWTMWGMFAR;GDVVKTNAGF;HTWGMFSR;IIGMMEFSLF;IPYDVQHVDIDY;ITPVLDEGAEKVMAYIPD;LQVALITEIDLILGEAY;PVNYKGFP;QEPAQNTHLSR;TAFRRDMNWTMWGMF 13 5.9 0.99375 -0.17391 0 0 0 0 0 0 0 10.2098 8.08948 0 9.51385 0 0 0 0 A0A8P0TBI4 A0A8P0TBI4_CANLF Olfactory receptor OR51B18 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TAPFLLTGFP;VHITMSYVYFLF 2 7.1 0.9914 -0.26975 0 9.10845 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TBJ2 A0A8P0TBJ2_CANLF Mitochondrial 2-oxodicarboxylate carrier (Solute carrier family 25 member 21) SLC25A21 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GLTEAIVV 1 3 1.0043 -1.1044 0 0 0 7.60088 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TBM0 A0A8P0TBM0_CANLF Kallikrein related peptidase 11 KLK11 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GVEGETERRGAWGG;MFALVTGHVRAET;PVPKPVEEPGACPSPLQAM;TLRCANITIINHEECEKA 4 18.6 0.98776 -0.37737 9.68392 0 0 0 0 0 7.80755 0 0 0 0 0 0 0 8.98382 A0A8P0TBM4 A0A8P0TBM4_CANLF L-lactate dehydrogenase (EC 1.1.1.27) Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] ATLKDQVIQNLLKE 1 3.9 0.98247 -0.24848 0 0 0 0 0 0 0 0 9.68811 0 0 0 0 0 0 A0A8P0TBN3 A0A8P0TBN3_CANLF Kirre like nephrin family adhesion molecule 3 KIRREL3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EAEEHPTIKQLMMDRGEF;ETSVTIDIQ;VGVHQYFELGLQKRGCCLVLGY 3 6 0.97808 0.047454 0 0 0 0 0 0 0 0 0 0 0 0 7.62176 0 0 A0A8P0TBN4 A0A8P0TBN4_CANLF "RAB17, member RAS onco family" RAB17 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] GTP binding [GO:0005525]; GTPase activity [GO:0003924] EVVVMLVGNKTDLG;SGSVGKSS;VPTPEAGG;VVMLVGNKTDLGEQ 4 7.7 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.40523 A0A8P0TBP7 A0A8P0TBP7_CANLF Tensin 1 TNS1 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925] phosphoprotein phosphatase activity [GO:0004721] APAVSREPRHPPGTRWPSAGK;EEDEGKVVT;GCREGAGCREGRRVQGGEQ;HYFSGLLSGSIKM;KVSSSPVASGMSSPSGG;LATCHQALRCPASGPGWL;LLHPTGEEDEGKVVTELPKEP;MSWDWRSRSGCS;PAPLRRRAA;PGLERHAAYGGY;PSTANEENFRS 11 7.4 1.0034 -2.0648 10.7703 0 9.03111 8.83061 8.13443 0 0 9.81908 0 0 0 11.7958 0 0 8.22579 A0A8P0TBQ1 A0A8P0TBQ1_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EDEADSCCAE;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 7 23.4 0.99957 -0.61146 0 0 0 0 0 0 0 7.17742 0 0 0 0 0 0 0 A0A8P0TBQ6 A0A8P0TBQ6_CANLF Ig-like domain-containing protein LOC106559612 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TLIVIFILLFILGVFLIYK 1 6.1 0.95439 0.04941 0 4.67265 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TBR9 A0A8P0TBR9_CANLF SH2B adaptor protein 1 SH2B1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] signaling adaptor activity [GO:0035591] LVSYVVSSQRQQGE;MGRGGGAA;RRRGRQKWRQQQPQQPKRGKRKRKR;SHGVFLVRQSETRRGE 4 8.6 0.99565 -0.11694 0 0 0 0 0 10.5216 0 7.03991 0 0 10.1157 0 0 0 0 A0A8P0TBU3 A0A8P0TBU3_CANLF SKI2 subunit of superkiller complex SKIC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VICWNLWIWVGVMRMR 1 13.3 0.99429 -0.13235 0 0 0 0 10.9972 0 0 0 0 0 0 0 0 0 0 A0A8P0TBU4 A0A8P0TBU4_CANLF Parvin alpha PARVA Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155] actin binding [GO:0003779] SLVAILHLLV 1 3.3 0.99935 -0.61146 0 0 0 0 0 0 0 5.04627 0 0 0 0 0 0 0 A0A8P0TBW7 A0A8P0TBW7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) GVAGSSDVVLVSYGVSS 1 6.6 0.97664 0.046227 0 0 0 0 0 7.50684 0 0 0 0 0 0 0 0 0 A0A8P0TBW8 A0A8P0TBW8_CANLF Inhibitor of Bruton tyrosine kinase IBTK Canis lupus familiaris (Dog) (Canis familiaris) APRQVSALHHKD;DILEVILDYLYT;DILEVILDYLYTD;ESMFKKAKTKAKKKPRKR;LVSGGRMEYKVDPE;QSDPKTRLDGVRFE;TDVYTWGDNTNFT 7 7.3 0.98412 -0.24769 0 10.8803 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TBX8 A0A8P0TBX8_CANLF Fucose kinase FCSK Canis lupus familiaris (Dog) (Canis familiaris) "ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]" HHIAACGLWPDS;HVLEARQDLSLR 2 2.2 0.9913 -0.22194 0 0 0 0 0 0 0 0 9.69356 0 0 0 0 0 0 A0A8P0TBX9 A0A8P0TBX9_CANLF "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12)" SLC2A12 Canis lupus familiaris (Dog) (Canis familiaris) endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] EDHHPDLLFSFHCSF 1 2.7 0.98953 -0.26403 0 0 9.4188 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TBZ0 A0A8P0TBZ0_CANLF "Transporter 1, ATP binding cassette subfamily B member" TAP1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] IGFFHDSRQ;LADWALLREVLPAV;LFRELRSWRAPRDSDSPRLLHWGSR;SLSLTMVTVVTLPLLFLL;TSLNLEGLVQFQDVS;VGQKQCLAIAR;WILQDETASAFTRNI 7 14.9 0.99632 -0.58179 0 7.26969 0 0 8.05967 0 0 0 8.08204 0 0 0 10.6121 0 0 A0A8P0TBZ2 A0A8P0TBZ2_CANLF Xyloside xylosyltransferase 1 XXYLT1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-xylosyltransferase activity [GO:0035252] HPELFHVLDC;PAAGAKAK;RHTFWQFRH 3 6.9 1.0032 -1.1044 0 0 0 0 0 0 9.64221 0 0 7.84059 0 0 0 0 0 A0A8P0TBZ3 A0A8P0TBZ3_CANLF Par-3 family cell polarity regulator beta PARD3B Canis lupus familiaris (Dog) (Canis familiaris) AQDPRQKNPMTAA;EGTFLPRELK;ESLQTAVAEVRKNELPFHR;HDMDDDEMDPNY;MEGNIRGMIQL;PDQHIHFRSVTP 6 7.1 1.0029 -1.345 6.93239 0 5.73977 0 11.1831 0 0 0 0 0 0 0 0 10.2209 0 A0A8P0TBZ8 A0A8P0TBZ8_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AEDEADYYCSSWGD;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 7 21.6 0.99065 -0.26822 0 0 0 0 0 0 8.89972 0 0 0 0 0 0 0 0 A0A8P0TC26 A0A8P0TC26_CANLF BEN domain containing 7 BEND7 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] DDHGILLVPVVLWTDVFTEKYCTAN;NCCTCNCQS;PEVQLAEGFDVFMPKSQLDSILSNY;PTAEHPSSGESRVLGFGIVLESP;VGSNCCTCNCQ 5 19 1.001 -0.6251 0 10.1376 0 8.92139 0 6.51784 4.94223 0 0 0 0 0 0 9.05241 0 A0A8P0TC30 A0A8P0TC30_CANLF Histone acetyltransferase (EC 2.3.1.48) KAT6A Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355] nucleosome [GO:0000786]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; metal ion binding [GO:0046872] DNMLFCDSCDRGFHMECCDP;EEEEMHAEAEEVEEG;EETLAACQTLQ;EIDEEEEEEDENELFSRGYFH;EIHTWYSSPYPQEYS;EPDTSTPMKKKKGWPKGKSRKP;EQEEEDEVAIETNQNEDHD;ETSTPQEQYGECEE;HHSYMNAAGV;IETNQNEDHDADDEDD;ILTKPTLKRKKPILHRR;LQSYTQADEDPQMSMVEDCHASE;MELFRDIQEQ;PGDFGAGSYSQPSATFSLAKL;PILTKPTLKRKKPILHRRRRVR;PVDVDPECLRWTPV;RGYFHRLSSQ;SGFHQQLRLAIK;SSEEEEEPESP;SSYDSTMGGSICGNNSSQSSC;SVQSHPSQSVRSVSSPNVP;TQERFSDKESKLLLEE;VEPIVPIPKQ;VSSPNVPALESG;YRLNTKATSVD 25 17.3 0.98427 -0.25501 0 0 10.0265 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TC31 A0A8P0TC31_CANLF threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) TARS3 Canis lupus familiaris (Dog) (Canis familiaris) threonyl-tRNA aminoacylation [GO:0006435] cytoplasm [GO:0005737] ATP binding [GO:0005524]; threonine-tRNA ligase activity [GO:0004829] LGEVELWDEAEKQLQNSL;RVRRFQQDDAHIFCTVEQIEEEI;VKERLKLYEILK;VTSAIHKLKNLKKSRIL 4 9.2 0.85474 0.19142 0 7.22824 0 8.43829 0 8.33033 0 0 0 0 0 0 9.6737 10.0052 0 A0A8P0TC34 A0A8P0TC34_CANLF ER lumen protein-retaining receptor KDELR1 Canis lupus familiaris (Dog) (Canis familiaris) protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031] COPI-coated vesicle membrane [GO:0030663]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139] ER retention sequence binding [GO:0046923] AAFSLSSPQ;LVNHDFTPLEILWTFSI;RFLGDLSHLLAIILLLLKIWKS;SQVLFAVVF 4 15.7 0.97393 0.046699 0 0 0 0 0 0 0 10.8764 0 0 0 0 0 0 0 A0A8P0TC51 A0A8P0TC51_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LSILPVIIRLK;TDLCMGLSTVHT 2 7.3 0.98975 -0.21734 0 0 0 0 0 0 0 0 0 0 10.5864 0 0 0 4.0635 A0A8P0TC63 A0A8P0TC63_CANLF Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; protein transport [GO:0015031] extracellular region [GO:0005576]; membrane [GO:0016020] ATSAPGYARFGQG;CSHNGWNSHNCRHSED;GFLFNASGTFSSP;PEASVQGGTESGLAL;SQPSPRIARFKFSSFYFLKRF;VDVIVGPIQLRAR;VICSDWWRPSSTTTHG;VQLEGGCNYDYIEVFDG 8 8.6 0.98882 -0.30787 0 0 0 0 0 0 0 7.73998 6.88277 0 0 0 10.9703 8.0013 9.9119 A0A8P0TC90 A0A8P0TC90_CANLF Dystonin DST Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament cytoskeleton organization [GO:0045104] cell projection [GO:0042995]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule [GO:0005874] actin binding [GO:0003779]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017] DISEIQSVCSDVET;DITQLEKEVNVCKQYYQELLKSAER;DLGTITNKCE;ELRDKWDTICGK;FSDEDDFSQ;FSQAATSASVPT;FYDTPLFEDDDHDSL;GSEKAALQSQLNTIKT;IDELVKSGHKIMAT;ISILRAAHEGL;KFSLENMAQKFKEFQ;KLLEIWIEFGRIKLLQ;LANLEHAFY;MVRVGGGWMALDEFLVKNDPCR;QEMKQIKVAQALCEDLSALV;RKAEKDMRELKYEL;SAETIDQDLNNLKEKW;SLVQEHSALSQQVDE;TIEAYRAAMQTQWSWILQL;TLRPWIDKCQNNLEEIKFC;TQKVEEIDAAILRSQQFD;VDIAGGKLASMSP;VGRDVETLQK;VGRYDDLSKSVNERNEKL;VIADKNNIENLI;WHYLINEIDRIRASNIKTM;YNLYISEVRNIRL 27 6.3 0.91391 0.11053 0 0 0 0 0 0 6.36182 0 0 0 8.00495 0 0 0 0 A0A8P0TC96 A0A8P0TC96_CANLF TATA-box binding protein associated factor 4b TAF4B Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription initiation [GO:0006352]; transcription by RNA polymerase II [GO:0006366] transcription factor TFIID complex [GO:0005669] protein heterodimerization activity [GO:0046982] GVSASGPVS;YKSRSNKEDPEQLRLKQ 2 3.2 0.99581 -0.11592 0 0 0 4.66869 0 0 0 0 9.66685 0 0 0 0 0 0 A0A8P0TC98 A0A8P0TC98_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACCSSSSPCQSSCCRQ;CCQQSSCQPSCCNSSPCQ;EDSCPSCGSCSPCQEGCC;PCQEDSCPSCGSCSPCQE;QPSCCNSSPCQEDSCPSCGSCSPCQ;QPSPCRPS;SSCQPSCCNSSPCQEDSCPSCG;SSCQPSCCNSSPCQEDSCPSCGSC 8 22.4 0.6881 0.2694 0 0 0 0 0 5.03628 0 6.90653 5.70188 0 0 5.15218 8.11671 6.19946 0 A0A8P0TCA6 A0A8P0TCA6_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) CDC14B Canis lupus familiaris (Dog) (Canis familiaris) intracellular non-membrane-bounded organelle [GO:0043232]; membrane-bounded organelle [GO:0043227] phosphoprotein phosphatase activity [GO:0004721] DAAYGSCNFYIT;IDNELEYENFYAD 2 5.5 0.99406 -0.056348 0 7.56993 0 0 0 0 0 0 0 0 0 8.50068 0 0 0 A0A8P0TCB5 A0A8P0TCB5_CANLF Trinucleotide repeat containing adaptor 6C TNRC6C Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytosol [GO:0005829] RNA binding [GO:0003723] GSSSAVQKEGSGGNAW;LKSNNMNLDQAMSALLE;LPGANGSSVSQVS;RNNPGLQS;SAKQNGSSSAVQKEGSGG;SITGAETESASECTTDTDSASNCGS;SLHPSAGKSSMDSFPPH;TLGAWGNLLPQESTE;VRSDPGHW;WEFEESPRSER 10 7 0.99082 -0.14712 0 11.6623 0 9.48971 7.62615 0 7.14323 0 0 11.7345 0 0 0 0 12.088 A0A8P0TCB9 A0A8P0TCB9_CANLF SUMO specific peptidase 5 SENP5 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] nucleolus [GO:0005730] cysteine-type peptidase activity [GO:0008234] AQRSWVQVTGDHQETL;EDGSLKQNI;GEGGNCSP;GVKRWTKKVDLFKKSLLLIPI;IHLAFSEKWNTGFGGF;KQNILSSKLLDH;LSICLSGFLDEVMKKYGSL;NGEGGNCSPFPSPE;TAVTKVSKYVI 9 15.7 1.003 -1.7052 0 5.37323 7.00034 7.18418 0 0 0 0 8.09998 0 0 0 0 9.289 0 A0A8P0TCC1 A0A8P0TCC1_CANLF Transmembrane protein 94 TMEM94 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HDALRDGK;KVLDFYQRACL;QEMLRCIWGHF;QSSIFTMC;VIDNIRWCLDMALSRPVTALDNE 5 5 0.98962 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.37221 A0A8P0TCC2 A0A8P0TCC2_CANLF Ankyrin repeat domain 17 ANKRD17 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AAAALTRMRAESTANAGQ;EEEDDDDE;EEEDDDDEEEEVSEVESF;EGIGGNQDKVDWCNPGM;EMVALLLGQGANINAQT;GGGGGGGA;GGGGGGGG;GGGGGTSSNNSEEEEDDDDEEE;HTALMEACMDGHVE;LDQDDLENP;LETASKLL;PAIDIDAQTESNHDT;QEKEKHKVE;QVNMPADSFESP;SEEEEDDDDE;VGGGGGGG;VGGGGGGGG;VGHSGIWSF 18 7.6 0.99751 -3.5524 0 14.4532 0 0 9.18423 14.0668 15.3362 15.2621 7.06577 14.8994 0 0 0 14.7608 14.3618 A0A8P0TCC8 A0A8P0TCC8_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) PPP3CC Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-mediated signaling [GO:0097720] calmodulin-dependent protein phosphatase activity [GO:0033192] GCSYFYSYPA;LVNILNICSDDELI;TTVRKEIIKNKIRAI;VGPHPVGG;VLFLWSLKINH 5 9.2 1.0035 -1.6537 0 0 0 0 0 0 0 7.62007 0 11.6155 0 0 0 0 0 A0A8P0TCC9 A0A8P0TCC9_CANLF Synaptonemal complex protein 2 SYCP2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome [GO:0005694]; nucleus [GO:0005634] ESKKLLTIILKNIIKIS;FDLLMVKIIRQVV;HMKQKSPSSISE;IEVMRCTEKI;KKLLTIILKNIIKISKRE;RRKFHVRQKI;SLKDLEKEFV;YFTKQSWKTAQQHLNTMNQQIQ 8 7.4 0.94396 0.059561 0 0 0 0 0 0 0 9.30861 0 0 0 0 0 0 0 A0A8P0TCF1 A0A8P0TCF1_CANLF Ufm1-specific protease 2 UFSP2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cysteine-type peptidase activity [GO:0008234]; ubiquitin-like protein peptidase activity [GO:0019783] ILFRIRGGL;VLSDLSTKLS 2 4.2 1.0036 -1.0628 0 0 0 0 3.25742 8.31379 0 0 0 0 0 0 0 0 0 A0A8P0TCF4 A0A8P0TCF4_CANLF Solute carrier family 25 member 23 SLC25A23 SLC25A41 Canis lupus familiaris (Dog) (Canis familiaris) transmembrane transport [GO:0055085] membrane [GO:0016020]; mitochondrion [GO:0005739] EQCKNYFCGVHGSPP;GLYRGMTPTL;KELQPGSVWVGAGSALQVL 3 8.8 1.0041 -1.0999 0 0 9.34946 0 0 0 0 0 0 0 0 0 10.302 0 0 A0A8P0TCG6 A0A8P0TCG6_CANLF RNA binding motif single stranded interacting protein 1 RBMS1 Canis lupus familiaris (Dog) (Canis familiaris) ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] AGAGRPAQPRSGRAPGASP;EGEVRLAGMTLTYDP;GGGGGGGE;GGGGGGGG;KQSLVPAHPMAPPSPS;NLYISNLPL 6 13.2 1.0032 -1.1163 8.97717 9.08369 0 0 9.15279 0 0 11.3649 0 8.00904 0 0 0 0 8.03656 A0A8P0TCG9 A0A8P0TCG9_CANLF HAUS augmin like complex subunit 8 HAUS8 Canis lupus familiaris (Dog) (Canis familiaris) DLQSTLLE;KKAHELKRKLLLCQRKRELADVLDA 2 8.8 0.65385 0.33821 0 0 0 9.61042 0 0 0 0 0 0 0 0 0 6.03507 0 A0A8P0TCH0 A0A8P0TCH0_CANLF Fibrosin like 1 FBRSL1 Canis lupus familiaris (Dog) (Canis familiaris) AGHGHGHG;DLEPACDR;PAAGLHPAPD;QPPGGGGP;QSRRSRAQRDRGRRREAARD 5 4.4 1.002 -1.408 6.5357 0 0 7.68475 0 0 0 0 0 7.6097 9.52415 0 0 0 10.0132 A0A8P0TCH6 A0A8P0TCH6_CANLF phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) PCK2 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613] EQESSKLHHVQG;EQGSQWPCNPEKT;LLEKQGLIRKLPK;VGWDRFVLRE;WICRRLEGEDS 5 6.7 1.002 -1.4163 0 8.0765 8.64223 0 0 0 0 0 9.83287 0 0 0 0 0 0 A0A8P0TCI2 A0A8P0TCI2_CANLF Glucocorticoid induced 1 GLCCI1 Canis lupus familiaris (Dog) (Canis familiaris) SRVPCNVEGISPEL;TEDLLYDRDKG 2 11.1 0.99489 -0.12653 0 0 0 0 0 0 0 0 0 0 0 0 0 9.62227 0 A0A8P0TCJ1 A0A8P0TCJ1_CANLF SEC14 like lipid binding 3 LOC486353 Canis lupus familiaris (Dog) (Canis familiaris) GGLTGYDYEGCP;MVPEDGSL 2 5 0.98774 -0.23421 0 0 0 0 0 0 0 0 0 0 8.27389 0 0 0 0 A0A8P0TCJ4 A0A8P0TCJ4_CANLF Leishmanolysin-like peptidase (EC 3.4.24.-) CIROP Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] ALSMGLCLTL;DCPSGPSV;GELEELTEALL;VGCHYLHLDKGSCS 4 6 1.0031 -1.9281 0 0 0 0 11.8991 0 0 0 0 0 0 9.72962 8.03524 0 6.516 A0A8P0TCK9 A0A8P0TCK9_CANLF 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) ALDH1L1 Canis lupus familiaris (Dog) (Canis familiaris) 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; one-carbon metabolic process [GO:0006730] cytosol [GO:0005829] "formyltetrahydrofolate dehydrogenase activity [GO:0016155]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" AGTVFVNTYNKTD;CQHGVEEG;EDHMFIAKEES;KECEILPDDTVSTLYNRF;LLADLMEQHQ 5 6.7 1.0028 -1.894 0 0 0 0 0 6.98675 14.9251 9.3619 0 9.24415 0 0 0 0 0 A0A8P0TCL1 A0A8P0TCL1_CANLF Spermatosis associated 5 like 1 AFG2B SPATA5L1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] AALHIVRGAPSPDPA;AIDETDFFEA;RVLSVLLNELDGVGLKTTERRG;SLPDGGSCLCT;VLLAGPPG 5 9.2 1.0033 -2.1061 11.1792 0 0 0 0 9.66181 0 9.59034 11.4799 0 0 0 0 0 0 A0A8P0TCM0 A0A8P0TCM0_CANLF EGF containing fibulin extracellular matrix protein 1 EFEMP1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] EQSEHNVCQDEC;QCPQGYQKRGDQCVDID;RCVCPVSSAVCR 3 8.2 1.003 -0.85588 9.3458 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TCN5 A0A8P0TCN5_CANLF Cullin 2 CUL2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] YLGKPYVAMVTTYQMA 1 2.3 0.96276 0.049233 0 0 0 6.24049 6.45585 0 0 0 0 4.06858 0 0 0 0 0 A0A8P0TCN9 A0A8P0TCN9_CANLF M-phase inducer phosphatase (EC 3.1.3.48) CDC25C Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; positive regulation of cell cycle G2/M phase transition [GO:1902751] protein tyrosine phosphatase activity [GO:0004725] KKENDHGNILESEIKY;MLEEDSYQGSL;YRDFFPEYTELC 3 8.6 0.99427 -0.18955 8.82184 0 0 0 0 8.85835 0 0 0 9.15694 0 0 0 0 0 A0A8P0TCP1 A0A8P0TCP1_CANLF Leucine rich repeat and coiled-coil centrosomal protein 1 LRRCC1 Canis lupus familiaris (Dog) (Canis familiaris) AAAGICASWTKAYGGLE;DLHSLALLTTDRL;HTKNNNPFMSCNRKMKQPFFK;IVEAHHAEIIQL;LISNRGKLEAQIESL;TLEILIEDDKQKSIQ 6 9.8 0.97643 0.046227 0 0 0 0 0 0 0 9.36455 0 0 0 0 0 0 0 A0A8P0TCP3 A0A8P0TCP3_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) UCHL1 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-dependent protein catabolic process [GO:0006511] endoplasmic reticulum membrane [GO:0005789] cysteine-type deubiquitinase activity [GO:0004843] QEVSPKVYFMKQT;SAFLLWHSARQPNALGEGH 2 13.3 0.95017 0.049713 0 0 0 0 0 0 0 0 0 0 0 0 0 6.81006 0 A0A8P0TCQ0 A0A8P0TCQ0_CANLF Lysine methyltransferase 2E (inactive) KMT2E Canis lupus familiaris (Dog) (Canis familiaris) ENPEPMTTSECP;GSLSQQTVFASGPNQALPGTSG;GTEITIAFDFDYGNC;IEDGTIHL;KDISKEKDTQNQ;PGPAPHHHP;PLKKRRLYQLL;RRLYQLLDSAY;TEVNRQCPGEKESVSDLQ 9 6.9 1.0033 -1.7034 0 0 3.96458 0 0 0 0 10.5523 11.4829 8.53142 8.77334 0 0 7.2181 6.56564 A0A8P0TCQ9 A0A8P0TCQ9_CANLF ZFP82 zinc finger protein ZNF566 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] IHFVEKPYECKECGKSFRVRQ;VMFNDVSIVFSQEEWE 2 7.4 0.93663 0.098911 0 4.12276 0 0 6.3935 0 0 0 0 0 0 0 0 0 0 A0A8P0TCS6 A0A8P0TCS6_CANLF Olfactory receptor OR5K1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DRYVAICSPLQ;ITVLRKILKKKK;KEVITVLRKILKKKK;RYVAICSPLQYHTMMSKKL;SLRNKEVITVLRKILKK;SLRNKEVITVLRKILKKK;VITVLRKILKKK 7 12.6 0.99235 -0.04051 11.2797 0 0 0 0 0 9.16503 5.36201 5.42072 8.53749 7.79116 0 0 8.52963 0 A0A8P0TCS8 A0A8P0TCS8_CANLF Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) MAP4K2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase kinase kinase kinase activity [GO:0008349] EPWEEEWTLLGKEEL;FIGTPYWMAPE;HRDIILESIPT;VTWIHPVTRDQ 4 5.9 0.98629 -0.45102 0 8.41773 0 0 0 0 0 0 0 0 8.69829 0 0 0 10.2359 A0A8P0TCT3 A0A8P0TCT3_CANLF Galactocerebrosidase (EC 3.2.1.46) (Galactosylceramidase) GALC Canis lupus familiaris (Dog) (Canis familiaris) galactosylceramide catabolic process [GO:0006683] galactosylceramidase activity [GO:0004336] VGAKHYHDLDIDYIGIWNERS;VGAVSGGGP;VWYTKLGKPSE 3 6.2 1.0036 -1.0559 0 0 0 0 0 0 0 9.64944 9.48303 0 0 0 0 0 0 A0A8P0TCT4 A0A8P0TCT4_CANLF Contactin 4 CNTN4 Canis lupus familiaris (Dog) (Canis familiaris) QDAGMYQCIATNS;RWLKNGEPLLTRDRIQI;VKYWRHDDKEENAR;VLPCQVTHDHSLDI;VTVGESIVLPCQVTHDHSL 5 6.5 0.99329 -0.046727 11.618 0 0 0 7.851 0 0 0 7.25918 0 0 0 0 0 6.18015 A0A8P0TCU1 A0A8P0TCU1_CANLF Methyl-CpG binding domain protein 1 MBD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] DCGHCDFCCD;DIKCGRRRTLWRARERAGTSEDG;VGCGECAA 3 6.8 0.98505 -0.25895 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.15416 A0A8P0TCV6 A0A8P0TCV6_CANLF Transmembrane protein 213 TMEM213 Canis lupus familiaris (Dog) (Canis familiaris) RSRYLANLQGEAD 1 12.4 0.98181 -0.24872 0 0 0 0 0 0 3.11328 0 0 0 0 9.31906 0 0 0 A0A8P0TCV7 A0A8P0TCV7_CANLF Transport and golgi organization 2 homolog TANGO2 Canis lupus familiaris (Dog) (Canis familiaris) SNALLETPWRKLCFGKQLF 1 7 0.95221 0.049538 0 0 8.47013 0 0 0 0 0 0 0 0 0 0 8.02176 0 A0A8P0TCY1 A0A8P0TCY1_CANLF L1 cell adhesion molecule L1CAM Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] ETFGEYSDNEEKAF;ISAIILLLLILLI;ISAIILLLLILLILCFIKR;ITEQSPRRLV;LLCKAFGAP;PSQDCGAGAPGPG;SSAVLVRWW;VGSPGPVP;VHFKPKEELGVTV;WFIGFISAIILLLLIL 10 7 0.99718 -3.9922 10.4369 0 9.37693 0 8.7047 0 6.36817 0 0 12.3007 0 0 0 10.6426 9.31442 A0A8P0TCZ1 A0A8P0TCZ1_CANLF procollagen-proline 4-dioxygenase (EC 1.14.11.2) P4HA3 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum lumen [GO:0005788] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656] EPYVVLYHDFVN;VAYDMGDYYHAIPWLEEAVS 2 6.1 0.99455 -0.077904 9.50367 0 0 0 0 0 0 9.94924 0 0 0 0 0 0 0 A0A8P0TCZ4 A0A8P0TCZ4_CANLF CD300 molecule like family member g CD300LG Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PVINPTGP;VHLSHSHS 2 5 1.0026 -1.0213 0 0 0 0 0 0 0 0 11.3568 0 0 0 0 0 0 A0A8P0TD08 A0A8P0TD08_CANLF HBS1-like protein HBS1L Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417] cytoplasm [GO:0005737] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LEKRQGGKQLLNLVVIG;NVNKRTMH;TSIASSDVLDTVSKSVLPSH;VFRHQQFIYSQRDKPSLVEPV;WYKGLCLLEQ 5 11.4 0.97693 0.047759 0 0 0 0 0 10.1886 0 0 0 0 0 0 0 0 0 A0A8P0TD17 A0A8P0TD17_CANLF Zinc finger protein 286A ZNF286A Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ERHLREMLTH;MMETDVAD;PYECNECGKGFN;RSQAPVTFKDVAMDFT 4 8.8 1.003 -1.9533 0 0 0 0 6.34275 0 0 0 0 10.1628 0 0 0 0 9.39958 A0A8P0TD20 A0A8P0TD20_CANLF Nephrocystin 1 NPHP1 Canis lupus familiaris (Dog) (Canis familiaris) EAEEEDEEEEEEEES;EEETEAARWKVIAD;FQLLEEGNQ;LKLFDASGI;VLLKDRTSM 5 8.9 0.95042 0.053874 0 0 0 0 0 0 0 0 0 0 4.53792 0 0 0 0 A0A8P0TD31 A0A8P0TD31_CANLF 5-hydroxytryptamine receptor 3C LOC488101 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888] DPAVFQTIFNQ;LWLPDIFIVESMDVDQTPEGL 2 7.3 0.98985 -0.20222 0 0 0 9.70383 0 0 0 0 0 0 0 0 0 0 9.48016 A0A8P0TD37 A0A8P0TD37_CANLF DNA polymerase delta subunit 3 POLD3 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] delta DNA polymerase complex [GO:0043625] EPVKMQQKE;GVEGRALVTYKWLSY;RGATGPHV;SCTDSEEELKMKTSSIHR 4 9.5 1.0017 -1.8064 0 0 9.90827 0 0 0 0 10.4863 0 0 0 9.38048 0 0 0 A0A8P0TD41 A0A8P0TD41_CANLF Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) CPD Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] CKNMYPNEYFPHGITNG;HHDEYEDE;ISNKPNISEPEEP;LFLLLLLLLLLL;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLLQ;LPPLLFLLLLLLLLLL;LSHEFQDETDTEE;PFQQPIQPKDFHHHH;RLPPLLFLLLLLLLLLLQ;TYGHCPEITVY;VLTGYMPLT;VTGSGLENATIS;VVGRELLLNLIEYLCKNFGT 16 10.3 0.98671 -0.23521 0 0 8.81147 0 0 0 0 0 0 0 0 0 0 6.49736 0 A0A8P0TD64 A0A8P0TD64_CANLF ITPR interacting domain containing 2 ITPRID2 Canis lupus familiaris (Dog) (Canis familiaris) signaling receptor binding [GO:0005102] LSAQMQRMEV;RGSWQASET;SGLLAAVS 3 2.2 0.99032 -0.26765 0 0 0 9.72639 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TD65 A0A8P0TD65_CANLF Rho related BTB domain containing 1 RHOBTB1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LLQFLYTGQL;VGLAQIAELLE 2 3.3 0.98645 -0.41423 0 0 8.48864 0 0 0 0 0 0 0 0 0 0 0 10.6396 A0A8P0TD79 A0A8P0TD79_CANLF Regulator of G protein signaling 20 RGS20 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of signal transduction [GO:0009968] ACCFCWCC;ACCFCWCCCCSCS;ACCFCWCCCCSCSC;ACCFCWCCCCSCSCLTV;AGERGANACCFCWCCCCSCSCL;ANACCFCWCCCCS;ANACCFCWCCCCSC;ANACCFCWCCCCSCSC;ANACCFCWCCCCSCSCL;ANACCFCWCCCCSCSCLT;ANACCFCWCCCCSCSCLTV;CCCCSCSCLT;CCFCWCCCC;CCFCWCCCCSC;CCFCWCCCCSCSC;CCFCWCCCCSCSCL;CCFCWCCCCSCSCLTV;CFCWCCCCSCS;CFCWCCCCSCSCL;CFCWCCCCSCSCLTV;CWCCCCSCSC;CWCCCCSCSCLT;CWCCCCSCSCLTV;ERGANACCFCWCCCC;FCWCCCCSCSCL;GAGERGANACCFCWCCCCS;GANACCFCWCCCC;GANACCFCWCCCCS;GANACCFCWCCCCSCSC;GANACCFCWCCCCSCSCL;GERGANACCFCWCCCCSCSC;NACCFCWCCCCS;NACCFCWCCCCSCSCL;NACCFCWCCCCSCSCLT;RGANACCFCWCCCCSC;RGANACCFCWCCCCSCS;VSRGASSR 37 7.5 0.99057 -0.21543 4.24092 0 0 0 4.52463 0 7.61824 0 0 0 4.1254 0 0 5.39732 0 A0A8P0TD82 A0A8P0TD82_CANLF Helicase with zinc finger HELZ Canis lupus familiaris (Dog) (Canis familiaris) helicase activity [GO:0004386]; metal ion binding [GO:0046872] CTSAHSQEELAE;DENPPGLPIGEALDRMH;DLLYIEEIAQYKEVSK;GSIPYPHHHHPHPHLQ;HQTWTFALTCKPARMLYR;LRRKWPVAWGKL;MLTGVSGGAKYAQN 7 5.5 0.98676 -0.33249 0 9.88923 13.2265 9.92359 12.7674 12.928 0 0 13.2936 13.1981 0 0 0 13.4143 14.047 A0A8P0TD83 A0A8P0TD83_CANLF Sorting nexin 13 SNX13 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] phosphatidylinositol binding [GO:0035091] DNVALQFFMD;GFVVTLLFGKTNSEKYL;LEAVRDKAAEELQYLRS;RRRHGDGHVPPAAP;SPLPRVPNRPG;VGGGSGSFRCCYGCC 6 7.3 1.0013 -0.91983 0 9.49506 9.6462 8.6233 0 0 6.91229 0 0 7.66995 9.2914 8.80874 0 0 0 A0A8P0TD84 A0A8P0TD84_CANLF Protein phosphatase 6 regulatory subunit 2 PPP6R2 Canis lupus familiaris (Dog) (Canis familiaris) protein phosphatase binding [GO:0019903] DCRGRWENFVEETLAE;DKTAGALEAVSMGP;LEAVSMGP;TEQVILFLKKK 4 4.6 0.99711 -0.10613 8.41819 0 1.99975 0 0 0 9.85776 0 0 4.21808 0 0 0 0 0 A0A8P0TD97 A0A8P0TD97_CANLF ethanolamine kinase (EC 2.7.1.82) CHKA Canis lupus familiaris (Dog) (Canis familiaris) AEIAEKMATFHGMKMPFNKEPKWL;CHNDCQEGN;DIGNHFCEWMYDYTYEKYPFFRAN;EGRENSEKQRL;GGGGGGGG;GGGGNAAP 6 18.4 1.0029 -2.1146 0 0 4.78257 8.70103 0 5.61947 9.66046 0 0 0 0 0 0 0 0 A0A8P0TDA1 A0A8P0TDA1_CANLF Transmembrane protein 67 TMEM67 Canis lupus familiaris (Dog) (Canis familiaris) cilium assembly [GO:0060271] membrane [GO:0016020]; MKS complex [GO:0036038] HVLVERDVNGTL;IDHVHKEMDYF;NLTSCQALGNMCVMNMN;TVLFFLEV 4 5.3 0.98666 -0.3306 0 9.64126 0 0 0 0 11.4447 0 10.833 0 0 0 0 0 0 A0A8P0TDB8 A0A8P0TDB8_CANLF Sterile alpha motif domain containing 8 SAMD8 Canis lupus familiaris (Dog) (Canis familiaris) sphingolipid metabolic process [GO:0006665] membrane [GO:0016020] "phosphotransferase activity, for other substituted phosphate groups [GO:0016780]" DPEYWKTILSCIYVFIVFG;FLDRSILLRRL;HIDVLEEMG;ILGDIKRLMLSVRKLQK;LEIKILGDIKRLMLSVRKLQK;QSRRARIWFPMFSFF;TTKHVAVWLKDEGFFEYVDV;VSNAATLPVWAPPR 8 18.8 1.0034 -1.1122 8.12309 0 0 7.22747 0 0 9.62606 0 0 0 0 4.31846 0 10.0524 11.4014 A0A8P0TDE7 A0A8P0TDE7_CANLF Microtubule associated protein 7 MAP7 Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] microtubule cytoskeleton [GO:0015630] EKEEREKREQEELERQ;LVLRVDDRQRLAR;QHYEKHLEERKKKLEEQRLKEERRR;QLRRQAEERERRER;RRRAAVEEKRRQRLE;SIRSAGGFVESSFTFLD;WGGPLHGS 7 13.3 1.0026 -0.79901 0 0 0 8.15527 0 0 3.91246 0 3.7419 7.26435 9.41528 0 0 0 0 A0A8P0TDF0 A0A8P0TDF0_CANLF Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176) BBOF1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] DNMEQKYTVQINELEGRFHQK;EVERFFLDALHQV;LDERTEVERFF 3 7.8 0.98647 -0.23523 0 0 0 0 7.64328 0 0 0 0 0 0 0 0 0 5.8583 A0A8P0TDG4 A0A8P0TDG4_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) PSMSVTLRQT;SIGSKRVYWYQQKLGQV;TESLSPICVTLPS;YVLTQLPSM 4 19.2 0.72434 0.24903 10.5695 9.98527 10.4413 0 0 0 7.36781 11.5718 10.2894 9.73342 9.95839 0 7.84887 10.1183 10.1357 A0A8P0TDH4 A0A8P0TDH4_CANLF "NPHS1 adhesion molecule, nephrin" NPHS1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DHTNIQLVSISR;EFLGEQVLVVT;HSSLLTIANVSAAQDYALFT;KLFTTEATARVT;LGEEEEDQSLDD;LVSPRVILSVLVP;RVTPQSSDNGQLL;TLNVKYPAQKLWI;VGISEKTE;VIEWPGLDE 10 10 1.0032 -1.6962 5.25248 0 11.0878 11.2836 8.79351 8.35636 0 0 11.6977 4.19669 12.4257 0 0 10.3244 0 A0A8P0TDH6 A0A8P0TDH6_CANLF ETS domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] QEPRDYYVNSEVPNCQSSY 1 4.7 0.95249 0.049538 0 0 0 0 0 0 0 0 9.56699 0 0 0 0 0 0 A0A8P0TDI1 A0A8P0TDI1_CANLF AT-rich interaction domain 1A ARID1A Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338] brahma complex [GO:0035060]; SWI/SNF complex [GO:0016514] DNA binding [GO:0003677] ESNGGGGG;GGGGGGGA;GGPGAEPDLKNSNGNA;KHPGLLLILGKLILLHHKHPER;LANLAQGDSL;NVGTSSSA;PGLLLILGKLIL;PGLLLILGKLILL;PSHGTRQPPYGPSAPVP;PYGGPYDRVRT;QQREEAGGEAAAAAAAE;RRPAGGPQNQFPFQF;TEEKAMGMTNLPAVG;TEHIQTHFESKTELL 14 7.6 1.0011 -2.715 9.40359 10.7238 0 8.58421 0 0 12.1303 0 9.77859 20.1262 20.1277 0 0 12.0218 8.16611 A0A8P0TDI2 A0A8P0TDI2_CANLF ADAM metallopeptidase with thrombospondin type 1 motif 9 ADAMTS9 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508] extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] CVGRRMKFKSCNTEPCLKQKRDFR;EDGEYFLLIKGKLLKIF;EPGKHCKFGFCVP;EQRACESGPCPQWAYGNWG;GVCGGDNS;GVCGGDNSS;KTAVRECNRPEPK;PGENQTKFYSEEE;QEDEEEQNKPHIVYRHSTLHR;STAFTIAH;TDSTREKRTHRRTK;TKFYSEEEAELKH;VIDQSECDPDYIPE 13 9.4 0.99947 -2.868 7.52724 9.51745 9.49551 0 6.68958 7.56369 10.7677 0 10.4285 6.45536 0 6.75836 0 7.85387 0 A0A8P0TDJ6 A0A8P0TDJ6_CANLF Potassium voltage-gated channel subfamily Q member 3 KCNQ3 Canis lupus familiaris (Dog) (Canis familiaris) voltage-gated potassium channel complex [GO:0008076] voltage-gated potassium channel activity [GO:0005249] AAGGGGGG;GGGGGGGA;GGGGGGGG;NVLATSLRSLRFLQ;TFREYETVS 5 4.4 1.0037 -1.0661 10.361 0 0 0 0 0 0 12.9468 0 0 0 0 2.95438 0 3.23205 A0A8P0TDJ9 A0A8P0TDJ9_CANLF SHH signaling and ciliosis regulator SDCCAG8 SDCCAG8 Canis lupus familiaris (Dog) (Canis familiaris) centrosome cycle [GO:0007098] centrosome [GO:0005813] FRAVSSQVKP;SLKLTELLSESEH;YQLNKTKMEKDEAE 3 5.1 1.0033 -0.87518 0 0 0 0 0 0 8.69933 0 0 0 7.30305 7.252 0 0 0 A0A8P0TDK6 A0A8P0TDK6_CANLF Tubulin alpha-1B chain Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based process [GO:0007017] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] ACWELYCREHGIQPDA 1 15.4 0.96187 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 3.31435 0 0 A0A8P0TDK8 A0A8P0TDK8_CANLF "Proteasome 26S subunit, non-ATPase 12" PSMD12 Canis lupus familiaris (Dog) (Canis familiaris) proteasome complex [GO:0000502] TDLPIKLRLI;YGSMEKKERVEFILEQMRLCLA 2 7.7 0.99532 -0.56449 10.5352 3.88225 0 0 0 0 0 5.64334 0 0 0 0 0 0 0 A0A8P0TDL5 A0A8P0TDL5_CANLF Solute carrier family 13 member 3 SLC13A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] solute:sodium symporter activity [GO:0015370] EDKDCPEA;HHSSAIRLGQQHLSD;LGQQHLSDPLSPTP 3 4.8 0.98519 -0.44711 8.9481 0 0 0 0 0 0 0 9.1692 6.5758 0 0 0 0 0 A0A8P0TDM8 A0A8P0TDM8_CANLF Olfactory receptor OR6C83 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VTLLVTLLLVIL 1 3.9 0.94725 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 4.68465 0 0 A0A8P0TDN2 A0A8P0TDN2_CANLF Sarcosine dehydrogenase SARDH Canis lupus familiaris (Dog) (Canis familiaris) DPSGGPVSLDFVK;LDEYKRLMSLGKAYGVES;TEHGSIQTPCVVNCA;TRRVVSRDLEEET;VLSPAETKALYPLMNVDDLYG 5 9 1.002 -0.65625 14.1346 0 0 0 7.92523 0 10.5809 0 0 0 5.02839 0 0 0 0 A0A8P0TDN5 A0A8P0TDN5_CANLF Nipsnap homolog 2 NIPSNAP2 Canis lupus familiaris (Dog) (Canis familiaris) AVGRRRRRRRQRRPARR;ELRSYQLRPGTMIEW 2 8.9 0.92152 0.11971 0 4.99426 0 0 9.71632 0 0 0 0 0 0 0 0 0 0 A0A8P0TDP1 A0A8P0TDP1_CANLF Kinesin family member 21A KIF21A Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ACVSPSDRDFM;DKAFTFDYVFDIDSQQ;DLFDTTRDIDAKN;EVSDHEEEEEEEEEEEDDI;GRLKQTEIT;GVVPGHPVLL;IDLAKKDLEKLKRKEKKKKK;KLKRKEKKKKKRLQ;KLKRKEKKKKKRLQKLEE;LDALLGHALQENVEDST;LEKLKRKEKKKKKR;QEVSDHEEEEEEEE;RKLSSSDTPVQDMGSTAAAVEA;SPLQCIHIAEGHT 14 9.6 0.99198 -0.54204 9.54104 7.48478 9.79364 7.38327 0 11.3391 0 11.791 5.11782 5.69602 3.06578 0 0 0 5.54161 A0A8P0TDP8 A0A8P0TDP8_CANLF Tektin 4 TEKT4 Canis lupus familiaris (Dog) (Canis familiaris) cilium movement involved in cell motility [GO:0060294] cilium [GO:0005929] ELEDTRHKLQNHLHKTLREITEQE;PCTHPGHAALPAPGA;RCSQEDATRKAGARLQ 3 8.6 0.86142 0.17368 0 0 5.9476 0 6.75515 0 0 0 0 8.35848 0 0 0 0 0 A0A8P0TDS6 A0A8P0TDS6_CANLF Zinc finger protein 827 ZNF827 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] EQPKRLPSPSE;NAADRPANHTKL;SWKFNDQLFP 3 4.5 0.99014 -0.26382 0 0 9.84837 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TDS7 A0A8P0TDS7_CANLF Paraoxonase (EC 3.1.1.2) PON2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] arylesterase activity [GO:0004064]; metal ion binding [GO:0046872] IDFFFFLNRNRLKASREVESV;IDSDDTVYLFVVNH;VCGVSSVC 3 11.4 1.0019 -1.2842 0 0 9.33096 8.68787 0 0 0 8.72516 0 0 0 7.05907 0 0 0 A0A8P0TDV1 A0A8P0TDV1_CANLF Vacuolar protein sorting-associated protein 51 homolog VPS51 Canis lupus familiaris (Dog) (Canis familiaris) "endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; lipid transport [GO:0006869]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938] PRAGRAAA;RFGLQQVQVDCHFLQLYLWRFVAD 2 4.4 1.0035 -1.0631 0 0 0 5.4552 0 0 0 0 9.53627 0 0 0 0 0 0 A0A8P0TDV4 A0A8P0TDV4_CANLF Plexin domain containing 1 PLXDC1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FIVQWDHVYLQGRED;GGGGHPPA;GKTCEDFQDEGH;GVGGGGHP;NPSPDVPESRR;QLSQDPGGGTLA;VGIVLAVLLVAAIIL;VSELDRTQLSQDPGG 8 11.8 0.99741 -3.5588 7.7707 4.68431 0 0 0 0 0 0 0 0 0 9.78203 4.99842 9.76683 0 A0A8P0TDX5 A0A8P0TDX5_CANLF "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (E2K)" DLST Canis lupus familiaris (Dog) (Canis familiaris) tricarboxylic acid cycle [GO:0006099] mitochondrial matrix [GO:0005759]; oxoglutarate dehydrogenase complex [GO:0045252] dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149] CFFVLGLGRQGSDS;PFALCLPEG 2 3.6 1.0024 -0.74001 0 0 0 0 0 0 0 0 0 0 9.27123 8.70359 0 0 0 A0A8P0TDY6 A0A8P0TDY6_CANLF DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37) DNMT3A Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; regulation of gene expression [GO:0010468] nucleus [GO:0005634] metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168] DSGPSELLPNGDL;GFGIGELVWGKL;PAGGQKGG;VLMCGNNNCCRC;VQQPTDPASPTVATTPEPVGADA 5 7.6 0.98746 -0.37001 0 7.12825 9.1418 0 0 0 0 10.5264 0 0 0 0 9.7248 0 12.572 A0A8P0TDZ8 A0A8P0TDZ8_CANLF "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (EC 2.7.1.159) (Inositol 1,3,4-trisphosphate 5/6-kinase)" ITPK1 Canis lupus familiaris (Dog) (Canis familiaris) inositol trisphosphate metabolic process [GO:0032957] "ATP binding [GO:0005524]; inositol tetrakisphosphate 1-kinase activity [GO:0047325]; inositol-1,3,4-trisphosphate 5-kinase activity [GO:0052726]; inositol-1,3,4-trisphosphate 6-kinase activity [GO:0052725]; isomerase activity [GO:0016853]; magnesium ion binding [GO:0000287]" AAGGGGGG;AGPGCCGS;GGGGGGGA;GGGGGGGG;GGVGGGGG;GPDPPWTSEADAGGMGAGGT;NLSRPIEEQGPLDVIIHKLTDVILE;PGGGGGGG;SEGEESWLLAEREENQEAEFP;SGDDTMRLLEQN;VIDINAFPGY 11 16.7 1.0033 -2.0833 0 0 10.3555 9.74549 8.26604 9.93887 0 0 0 0 0 8.12846 0 0 0 A0A8P0TE02 A0A8P0TE02_CANLF Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) PUF60 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904] RNA binding [GO:0003723] KGYGFIEYE;LATPGLVSPALT 2 4.2 1.0018 -0.75377 9.70491 0 0 0 0 0 10.1005 0 0 0 0 0 0 0 0 A0A8P0TE14 A0A8P0TE14_CANLF RAS p21 protein activator 2 RASA2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580] GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543] LTSRELTYHKQP 1 1.4 0.95171 0.05044 0 0 0 0 0 0 6.68636 0 0 0 0 0 0 0 0 A0A8P0TE60 A0A8P0TE60_CANLF Acyl-CoA thioesterase 12 ACOT12 Canis lupus familiaris (Dog) (Canis familiaris) carboxylic ester hydrolase activity [GO:0052689]; lipid binding [GO:0008289]; thiolester hydrolase activity [GO:0016790] AFDCQEWSEGRG;ATISASRLCGAH;KEEVPLCVHWDVTN;PMSKDDLRR;VEAFDCQEWSEG;VGQVLTIKAKVTR;YHGAIARKRIRLGRKYVISHK 7 15.8 0.9917 -0.54459 9.00177 0 0 0 8.45869 0 0 0 0 0 9.24928 4.51841 7.9939 0 0 A0A8P0TE67 A0A8P0TE67_CANLF phosphopyruvate hydratase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO2 Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] LVVGLCTGQT 1 2.3 0.98999 -0.26579 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.1198 A0A8P0TE90 A0A8P0TE90_CANLF Olfactory receptor LOC486582 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLTLPLILFSYS;VITSLVNP 2 6.6 1.004 -1.0539 0 0 0 0 0 0 0 0 0 0 0 0 0 3.58219 4.55582 A0A8P0TE95 A0A8P0TE95_CANLF Fer-1 like family member 4 FER1L4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] DIPDPEELDWWSKYYA;DVDGYNAWRDAFRPSQILAG;EAEFELLTVE;ISRGVPQNRPIKLLV;LRLQLRDDAPLVDV;QHEEREQREAQA;QPLLETDTGDGPGDEEE;RILVLLLLLALVAVFLLLVLY;RPIKLLVRVYV;RQVMLNFRGFTQ;RYWRILVLLLLLALVAVFLLLVLYT;SRGVPQNRPIKLL;VLLLLLALVAVFLLLVLYTMP;VRVYVVKAT;VWDYDRISANDF;YHPRSPGL;YPESEAVSFSEPK;YYASLQELQGQVGAEADGV 18 10.1 0.95399 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.21403 A0A8P0TE98 A0A8P0TE98_CANLF PITPNM family member 3 PITPNM3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ECVVFSIDGSFAASVSIMGSDPKVR;LVKFVPCPAV;PEASEVPGGPWREKP;PYSHDDGCLGNSQD 4 6.8 0.95367 0.053883 0 0 0 0 0 6.35632 0 0 0 0 0 0 0 0 0 A0A8P0TE99 A0A8P0TE99_CANLF Tumor protein D52 TPD52 Canis lupus familiaris (Dog) (Canis familiaris) CCHNWCHRDPI 1 5.3 0.98137 0.035491 0 0 0 0 0 0 0 0 1.8819 0 7.6471 3.49672 3.51084 0 0 A0A8P0TEA9 A0A8P0TEA9_CANLF Ribosomal L1 domain containing 1 LOC612497 Canis lupus familiaris (Dog) (Canis familiaris) KNKKSIVKNKKRRRKKRLMKQA;LDQGQMRKAVEA 2 7.8 0.93658 0.097139 3.47405 0 0 0 0 0 10.9233 0 0 0 0 0 0 0 0 A0A8P0TEC2 A0A8P0TEC2_CANLF Deoxynucleotidyltransferase terminal interacting protein 2 DNTTIP2 Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] APELTNELKND;APELTNELKNDL;IPKKQRKRTIVEEL;LILRVTRRRQILVA;NEEDTVCFVENNGQKESLN;SEAESNCSSVSELQDL;SNKTTSELSNLNCESIM 7 12.1 0.54787 0.42513 12.5532 12.6106 12.3401 10.3029 10.3526 10.6203 12.3709 12.9763 12.5694 12.631 12.3614 12.2448 11.4967 10.4251 11.4519 A0A8P0TED6 A0A8P0TED6_CANLF Rho-GAP domain-containing protein ARHGAP19 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] HVLWPKNAPVYI;KSQKRNWVD;TEEGIAQIYQ 3 6.7 1.0023 -1.2359 0 0 9.45562 0 9.18619 0 0 0 0 0 0 0 10.6598 11.1208 8.47654 A0A8P0TED9 A0A8P0TED9_CANLF ubiquitinyl hydrolase 1 (EC 3.4.19.12) ATXN3 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] nucleus [GO:0005634] cysteine-type deubiquitinase activity [GO:0004843] LINKIFITTDSP;TSEDYRTFLQ 2 17.9 0.94286 0.05044 0 0 0 0 0 5.52594 0 0 0 0 0 0 0 0 0 A0A8P0TEE6 A0A8P0TEE6_CANLF procollagen-lysine 5-dioxygenase (EC 1.14.11.4) PLOD2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-lysine 5-dioxygenase activity [GO:0008475] CRQDENCDYYFSMDADV;ITLDHKCKIFQTLNG;PPLLLLLL;PPLLLLLLL;PVDWKEKYINRDYSKIFTE 5 8.2 0.99332 -0.17461 0 0 8.11014 8.1266 7.33994 0 0 0 0 0 0 0 0 0 0 A0A8P0TEE9 A0A8P0TEE9_CANLF Sorting nexin 32 SNX32 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] phosphatidylinositol binding [GO:0035091] GVQEVNQLKMSFL;LADYENANKALDKARTRN;QELMDFKSRRVIS;YHTRIRDAC 4 14.3 1.0009 -0.6363 0 3.8955 0 0 5.7274 0 8.16254 0 0 6.05834 0 0 0 0 9.9622 A0A8P0TEG9 A0A8P0TEG9_CANLF Kirre like nephrin family adhesion molecule 1 KIRREL1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DAELSDDASYECQATE;HESRYETNVDYSFFTEPV;IELDVHHPPTV;LTATRARPRPPGP;NLTCRAFNAKPAATI 5 10 0.99009 -0.26572 0 0 0 0 0 0 0 11.3707 0 0 0 0 0 0 0 A0A8P0TEH0 A0A8P0TEH0_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EAPSWGAPPQ 1 6.4 0.99121 -0.27007 0 0 0 10.5818 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TEI7 A0A8P0TEI7_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; glycosyltransferase activity [GO:0016757] DTRQKWEQIEG;FKWDYMTPEQRRSRQGNPVAP;GKVRWRDF;PFKWYLENVYPELRVPDHQD;PYARNKFNQVESDKLR;SKLRHVGSNLCLDSRAAK 6 17.7 0.99302 -0.28163 0 0 8.30542 0 7.87934 5.89018 0 6.60165 0 8.76388 0 8.56746 0 0 0 A0A8P0TEJ8 A0A8P0TEJ8_CANLF ANTXR like ANTXRL Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] signaling receptor activity [GO:0038023] GVAEKVGSSSLWVPAP;HRHPSVPPGGRVLC;LLLLLLLP;PALPLLLLLLL;VLCEPRTFSPTSP 5 9.8 0.99293 -0.1694 0 5.08657 0 0 7.21946 0 0 0 0 0 0 0 0 0 7.63052 A0A8P0TEK5 A0A8P0TEK5_CANLF Rho guanine nucleotide exchange factor 28 ARHGEF28 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] EIRNLVTGRPSPEKEDVKRVDSP;ESLCHENS;GAAEAAHN;LVERILQYTKERSEEHQDLC;QAGDARPSPE;RITKYPVLVE;SVCDKTLLGKESSQCSN;VTQRITKYPVLVERI 8 6.1 1.0022 -1.8622 0 0 0 0 8.5868 0 5.14625 0 0 0 3.70962 6.72751 8.41469 11.0167 0 A0A8P0TEL0 A0A8P0TEL0_CANLF Crystallin beta-gamma domain containing 1 CRYBG1 Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of eye lens [GO:0005212] EGEGEGEGAAPGPEDCGDPDDME;GEYPDLSFWDTEEAYI;VLAPDGKAEPPTGPETEDKENRDVP;VVGGHVAP 4 3.5 1.0038 -1.0689 0 0 0 0 0 0 9.76313 0 0 0 0 0 10.2776 0 0 A0A8P0TEM7 A0A8P0TEM7_CANLF [histone H3]-lysine(4) N-methyltransferase (EC 2.1.1.364) KMT2B Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259]; regulation of DNA-templated transcription [GO:0006355] histone methyltransferase complex [GO:0035097] DNA binding [GO:0003677]; histone H3K4 methyltransferase activity [GO:0042800]; zinc ion binding [GO:0008270] AGKQLHSGPCDLQAVSRRFE;ETLESGQPP;KPPNPPSTPP;LRRLRRLWAGPRIQ;LVNKLGQVF;PNGVLPNAVLPPSLDH;PPPTSVVRA;QFTPSEAHL;RCYEDNDYESKMMQC;RNIDAGEM;SPADPTRTFAWL;SPLVPPEPAPAPSPP;TALLRLLGLRRGLRRLR;TDALIPGAPEHHSPVQN;VGSGQGEG 15 6.8 0.99741 -3.4975 11.4033 9.33257 12.4536 7.33976 9.57156 0 9.58892 8.73863 0 0 0 10.0429 11.3069 12.5331 0 A0A8P0TER3 A0A8P0TER3_CANLF Speedy protein E4-like LOC607286 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase binding [GO:0019901] RTRVSREECEEVGGLWGFGV 1 7.3 0.98237 -0.24853 0 0 0 0 7.7963 0 0 0 0 0 0 0 0 0 0 A0A8P0TES2 A0A8P0TES2_CANLF Bromo adjacent homology domain containing 1 BAHD1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin binding [GO:0003682] EAGMPESP;KPKACKVLLTRLENVAG;LPEAGHPASPAHP;LVFLCRHVYDFRHGRI;PSADYSTPP;RKNYPLRKRPLVPEKPKACKVLLT;VGAACEKAVYVLDEPEPAIRKS;VGPLGWQRHPE;VYVLDEPEPA 9 14.2 1.0007 -2.7692 9.83452 7.97068 10.937 0 0 7.99989 0 0 3.65272 0 10.9528 7.85125 0 5.30834 10.0614 A0A8P0TET0 A0A8P0TET0_CANLF Large ribosomal subunit protein uL22 (60S ribosomal protein L17) Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] IEMILTEKEQIVPKPEEEVAQK;LPPSGLRSHPEMVRYSLDP;SELALPPSG;SQKKLKKQKLMAW 4 30.7 1.002 -0.64788 0 9.22884 0 0 0 0 0 9.26066 0 0 8.99291 0 0 4.2322 0 A0A8P0TET1 A0A8P0TET1_CANLF TEPSIN adaptor related protein complex 4 accessory protein TEPSIN Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794] DEPDSSSSS;FAGNQAFLQPLSSTL;SVTTAQISLSSPEW 3 7.5 0.94272 0.061052 0 0 0 0 0 0 0 0 0 0 0 4.69332 0 0 0 A0A8P0TEU0 A0A8P0TEU0_CANLF Anoctamin ANO5 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] AAKMTFIIVMEHV;AIYPMVLNWWRRRKARTNSEKLY;EADFKANSEDG;KPSEPPNPV;LFYEYLET;LMTIKILHDFEL;PAETFPFSYMLGP;SEECDPGG 8 11.1 0.98928 0.035491 0 0 0 0 7.37408 0 0 0 0 0 0 0 0 0 0 A0A8P0TEU8 A0A8P0TEU8_CANLF Ataxin 2 like ATXN2L Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] AHYPSQPVFAPMLQSN;ESQELSRIAGK;GDSNSDDYDLESDMSNGW;LVAATPYSSYIPYTPQQFP;PQIHMGPAVQAP;PVFEGVYNNSRMLHFL;SLASREGKY;TSEPVGSP;TSSVVDPGVGSISPASPK;VPPPPAAF;YHPGALTGTPP 11 13.5 1.0033 -1.7024 5.13668 6.49691 0 0 0 8.81417 11.3814 0 10.0606 0 0 0 0 6.68061 0 A0A8P0TEV1 A0A8P0TEV1_CANLF Protein transport protein SEC23 SEC23B POLR3F Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789] zinc ion binding [GO:0008270] DPWPVTQGKRPL;FQRNQFPPAYTGISEVN;LEATRMVVPLA;PPEPVLLD;SPFLQVFNNSPD;TATNGHCI 6 9.4 1.0024 -1.8415 0 0 0 0 6.88289 0 9.42945 0 6.3052 0 0 0 9.63214 0 7.16451 A0A8P0TEW8 A0A8P0TEW8_CANLF Gamma-aminobutyric acid type B receptor subunit 2 GABBR2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled GABA receptor activity [GO:0004965] AMNETNFFGVT;CCAYEENMYGSKYQW;DTESFSND;GVTGQVVF;LLLLLLLP;LLLLLLLPLLLPLAP;LLLLLLPL;LLLLLPLL;RLLLLLLL;RVHAIFKNVKMKKKPD 10 7.7 0.95836 0.049233 0 0 0 0 0 0 8.35799 0 0 0 0 0 0 0 0 A0A8P0TEX9 A0A8P0TEX9_CANLF High density lipoprotein binding protein HDLBP Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] GAEHGPGG;VEKCTKYM 2 1 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 8.25758 0 0 A0A8P0TEY5 A0A8P0TEY5_CANLF Beta-defensin 108B CBD108 Canis lupus familiaris (Dog) (Canis familiaris) NIPNEGQRAPGTQ 1 8.3 0.93806 0.059743 0 0 0 0 0 8.5691 0 0 0 0 0 0 0 0 0 A0A8P0TF08 A0A8P0TF08_CANLF Vav guanine nucleotide exchange factor 2 VAV2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872] IRPFPSEETAEND;KYYRTLEDIEK;NNKDVKKSHGKMWSY;VARYNFAARDMRE 4 6.1 0.95727 0.053878 0 0 0 8.87409 0 0 3.337 4.23396 0 0 0 3.7761 0 4.07108 0 A0A8P0TF10 A0A8P0TF10_CANLF Erythrocyte membrane protein band 4.1 like 3 EPB41L3 Canis lupus familiaris (Dog) (Canis familiaris) cortical actin cytoskeleton organization [GO:0030866] cytoskeleton [GO:0005856] actin binding [GO:0003779]; structural molecule activity [GO:0005198] AEPMKAFPPTAD;EKDYFGLTYRDA;QKSSSSKLSRSPL;SLSASLDNDPSDSSEEETDSE;STRLTRMEPAEG;TETKTITYE;TETSHLAPSPQPLSTEK 7 8 0.88077 0.13863 0 10.3434 6.58589 0 0 6.41158 0 0 9.58573 9.23759 0 0 9.04551 0 0 A0A8P0TF29 A0A8P0TF29_CANLF Zinc finger protein 385D ZNF385D Canis lupus familiaris (Dog) (Canis familiaris) nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270] GVSVIVDSQTIMILNV;HKDRAAGKPPKPKYSPYNKLQ;VTAKDSAKTTFTS 3 13.4 0.99455 -0.15501 0 0 8.52705 0 5.97735 0 0 0 0 0 0 0 0 0 0 A0A8P0TF35 A0A8P0TF35_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPN5 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] VGDFWRMVWQE;VGDFWRMVWQEHTPIIVMITNIEEM;VPNLLLVTLSVI 3 7.6 0.90286 0.12147 0 0 0 0 0 9.17348 0 8.13242 0 0 0 0 0 0 5.05285 A0A8P0TF38 A0A8P0TF38_CANLF Adhesion G protein-coupled receptor B1 ADGRB1 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AGGWGRGGGAQRGREGA;ALFQILFAVFDSL;GAACQGPQDEYRQ;GAAGAGGG;GASLWSSC;GKQLASLLLLLPVLGLLLLLP;GKQLASLLLLLPVLGLLLLLPSPPR;HCILRREVQ;LLLLLPVLGLLLLLPSPP;LLYAFVGPAAAV;PDFPNHSLTL;PEEPKHSIH;PGGGKQLASLLLLLPVLGLLLLL;REHRRPRRVLAG;SLLLLLPVLGLLLLLPSPPRP;TPLEIEFAH;VLAGPGPARPASP 17 8.1 1.0035 -1.6854 5.97039 11.4536 0 11.2122 2.93274 0 7.35147 12.0014 10.4074 0 6.99503 7.75562 12.3885 0 0 A0A8P0TF39 A0A8P0TF39_CANLF RRM domain-containing protein LOC608314 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] HTIYINNLN 1 4.9 0.98273 -0.25017 0 0 0 0 0 0 0 0 0 0 0 0 0 8.92893 0 A0A8P0TF40 A0A8P0TF40_CANLF S-adenosyl-L-homocysteine hydrolase NAD binding domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) one-carbon metabolic process [GO:0006730] endoplasmic reticulum [GO:0005783] HTKYPQFLSGIQGIS;SENAIEKVNIKPQVDRYQLKNGC 2 12.9 0.99183 -0.20916 0 0 0 0 10.3707 0 9.24676 0 0 0 0 0 0 0 0 A0A8P0TF53 A0A8P0TF53_CANLF PALM2 and AKAP2 fusion PALM2AKAP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of cell shape [GO:0008360] plasma membrane [GO:0005886] EDNIQRLEQE;INVEKDKQ;SEEDEFRVKQL;VLDNDVAREIRYLD;WGGGGGGG 5 3.5 1.0023 -1.4062 0 7.62088 0 0 0 12.6741 0 0 0 0 9.37634 0 0 0 12.9381 A0A8P0TF77 A0A8P0TF77_CANLF SH3 and PX domains 2A SH3PXD2A Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol binding [GO:0035091] AGEVVDVIEKNE;EVIDKNSGG;KRRKAHLRRLDR;SIADYEGDEETAGF 4 4.4 0.99099 -0.19468 9.76253 0 0 0 0 10.184 0 0 0 0 0 0 11.267 0 11.1789 A0A8P0TF80 A0A8P0TF80_CANLF KN motif and ankyrin repeat domains 1 KANK1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of actin filament polymerization [GO:0030837] AGSRRDAA;ALMCASEHGHVEIV;IKKLNIPKRRKPSVPCP;LASFGGMG;PPQSLQEGGD;SCAISVTEAMLGV;SMGSSIRHSPLSSGI;TGQQGVWTSTESLSS;VGDYIAAFEAISPD;VGNSQVHEEERT;VLSGSAGFDRPSAVKT;VTKTLMETRRRLEQERVT;YEEEEMESVEQ 13 12.2 1.0028 -2.5241 9.21595 0 5.76378 13.3132 0 8.67437 9.50807 8.5008 11.8401 11.5021 0 9.7469 0 0 0 A0A8P0TF95 A0A8P0TF95_CANLF RAD17 checkpoint clamp loader component RAD17 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281] nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389] ATP binding [GO:0005524]; DNA clamp loader activity [GO:0003689] HFGRLKMEALTDREH;SSSKGASL;VTMEANKNGGNTIVPDKT 3 6.6 0.98752 -0.35313 0 0 0 0 9.35641 7.57319 0 0 0 0 9.66915 0 0 0 0 A0A8P0TF98 A0A8P0TF98_CANLF Microfibril associated protein 2 MFAP2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; microfibril [GO:0001527] EPTEPGPLDCREEQYP 1 8.7 0.94455 0.083913 0 0 0 0 0 0 0 0 0 0 0 5.52077 0 0 0 A0A8P0TFC8 A0A8P0TFC8_CANLF Ryanodine receptor 1 RYR1 Canis lupus familiaris (Dog) (Canis familiaris) DTRSRVLQEQ;GDVQASDKQFSGGV;LAGLLRELRCPDRA;LIPATSKAVRRGTCCAINKVLMGNV;PAGGARPADRTL 5 12.7 0.99638 -0.57362 0 0 0 9.61873 0 0 0 0 0 0 13.5697 13.6202 9.43377 0 0 A0A8P0TFE3 A0A8P0TFE3_CANLF Splicing factor 3B subunit 3 SF3B3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nucleic acid binding [GO:0003676] GAEKLRRTPALK;LTFYELDLGLNH;LVDELDSLSPILFCQ;VLICSENYITYKNF 4 4.6 0.9876 -0.40286 0 9.62761 0 10.37 0 9.90111 0 0 0 0 9.93924 0 0 0 0 A0A8P0TFF6 A0A8P0TFF6_CANLF BCR activator of RhoGEF and GTPase BCR Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] axon [GO:0030424]; dendritic spine [GO:0043197] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine/threonine kinase activity [GO:0004674] APAPPPAPAPAPPPAD;CCTSCSWRPSLP;FKSFSLTSVELQMLT;LDHLKRSRCCCT;NSLETLLYKPVDRVTR;TKITKEDGESTDRIM 6 6.5 0.99091 -0.21004 0 5.03082 0 0 0 9.26824 0 9.27116 0 2.43424 0 0 2.37787 0 4.62912 A0A8P0TFG0 A0A8P0TFG0_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] SEFSHSDEEMSE;VIHHVEDP 2 5.7 0.99068 -0.2109 0 0 0 0 0 0 10.5531 0 8.07986 0 0 0 0 0 0 A0A8P0TFH1 A0A8P0TFH1_CANLF Acyltransferase (EC 2.3.1.-) MOGAT1 Canis lupus familiaris (Dog) (Canis familiaris) glycerol metabolic process [GO:0006071] endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] PEGSWLRT;RCPLFREYLMT 2 6 1.0028 -0.73318 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.1926 A0A8P0TFH9 A0A8P0TFH9_CANLF Signal transducer and activator of transcription STAT4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ENQDWEAASNNETMATILLQNLLI;EQLGRVSKE;EQLGRVSKEKNLLLIHNLKRIRKVL;LLERVTFLIYNLFKKLLI;NLLLIHNLKRIRKVLQG;QVDQFYDDNFP;SLPVVMISN;VDQFYDDN 8 12.4 0.97756 0.048313 0 0 6.80516 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TFK4 A0A8P0TFK4_CANLF Origin recognition complex subunit 4 ORC4 Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260] nucleus [GO:0005634]; origin recognition complex [GO:0000808] DNA binding [GO:0003677] AADLMEANQLCSMDS;PFMTAADL 2 9.2 0.98692 -0.37976 0 0 0 0 8.53282 8.51321 0 14.1553 9.78655 0 9.13427 9.00935 0 0 0 A0A8P0TFK9 A0A8P0TFK9_CANLF Lamin A/C LMNA Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament [GO:0005882]; nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654] structural molecule activity [GO:0005198] EMLRRVDA;RLQLELSKVREEFK;VGAAHEELQ 3 5.4 1.0035 -1.0675 0 10.1529 0 9.65937 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TFL7 A0A8P0TFL7_CANLF Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) EIF2B5 Canis lupus familiaris (Dog) (Canis familiaris) biosynthetic process [GO:0009058] cytosol [GO:0005829] guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor binding [GO:0031369] GGGGGGGG;PGGGGGGG;TDNFDYQTRDD;VGAAGQGY;VQETFVFCCWKAAQIKEHLLKSKWC 5 8.1 1.0023 -1.3705 6.49779 6.57666 0 0 0 0 10.3936 0 0 0 0 0 0 0 0 A0A8P0TFN5 A0A8P0TFN5_CANLF GRB2 associated regulator of MAPK1 subtype 2 GAREM2 Canis lupus familiaris (Dog) (Canis familiaris) AAGGGGGG;GGGGGGGA;GGGGGGGG;GGGGGGPG;PYEELWTHQAAEGLA;VGGGGGGG;VGGGGGGGG 7 4.7 0.95104 0.053889 0 0 0 0 0 0 0 0 0 9.19419 0 0 0 0 0 A0A8P0TFR2 A0A8P0TFR2_CANLF Fc receptor like A FCRLA Canis lupus familiaris (Dog) (Canis familiaris) GYTFSKPFHLIVSYGPS;PSKNPGFSSPLQ 2 15 0.98446 0.046227 8.5932 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TFU1 A0A8P0TFU1_CANLF FKBP prolyl isomerase family member 15 FKBP15 Canis lupus familiaris (Dog) (Canis familiaris) PQMTTQAPQP;SLQPAHPVIPQMTTQAP 2 1.6 0.99118 -0.51363 0 0 0 0 0 0 0 0 10.511 0 8.95716 0 0 0 0 A0A8P0TFW3 A0A8P0TFW3_CANLF phosphorylase kinase (EC 2.7.11.19) PHKG1 Canis lupus familiaris (Dog) (Canis familiaris) glycogen metabolic process [GO:0005977] phosphorylase kinase complex [GO:0005964] ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689] PNIIQLKDTYETNTFFFLVF 1 4 0.94979 0.081577 0 0 0 0 0 0 0 4.04177 0 0 0 0 0 0 9.92717 A0A8P0TFX2 A0A8P0TFX2_CANLF Structural maintenance of chromosomes protein 3 (Chondroitin sulfate proteoglycan 6) SMC3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; chromosome organization [GO:0051276]; meiotic cell cycle [GO:0051321] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] EHMDAINHD;GINQHVQNGYHGIVM;MYIKQVIIQGFRSYRDQ;NNFECEPAFYTC;NYLWREENAEQQALAAKREDLEKK;YHIVDSDE 6 7.6 1.0033 -2.4439 0 0 7.43887 0 0 0 6.21711 0 0 0 8.16852 7.95449 8.99738 0 0 A0A8P0TFY9 A0A8P0TFY9_CANLF Endoplasmic reticulum junction formation protein lunapark LNPK Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum tubular network maintenance [GO:0071788]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373] endoplasmic reticulum tubular network membrane [GO:0098826] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] DGPQNRYALI;DTEQTNQGTEKVS;FSFEKRQAVESSSSLGP;LDRIVEYLV;PRADPIPN;YSSILYLFTCLIV 6 17.5 1.0035 -1.5957 11.1275 0 0 0 4.9079 4.10283 0 0 11.7645 8.79321 0 0 0 0 0 A0A8P0TFZ6 A0A8P0TFZ6_CANLF Vasoactive intestinal peptide receptor 2 VIPR2 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] vasoactive intestinal polypeptide receptor activity [GO:0004999] IVNFVLFVSIIRILLQ;PGWSLSCPLTPDTRPHRP 2 5.9 0.98014 0.048313 0 0 0 0 0 0 0 0 0 0 7.45968 0 0 0 0 A0A8P0TG02 A0A8P0TG02_CANLF Relaxin-3 RLN3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179] VSPHLPGV 1 4.7 1.0046 -1.1044 12.3057 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TG24 A0A8P0TG24_CANLF RUN domain-containing protein 3B RUNDC3B Canis lupus familiaris (Dog) (Canis familiaris) IEDSDLAHKLEKEQLEYIIVELQ;ISSDEEELRTLGS;PPLSGPPRSQSEQEP;SQNCICSI;VGPRSCPPAPAPRLPPLSGPP 5 11.8 0.94552 0.10166 0 8.04193 8.60744 0 0 0 0 0 0 8.26472 0 0 0 0 0 A0A8P0TG35 A0A8P0TG35_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) MDAFLESHKL;QKRPRIAKGILKK 2 2.7 0.99085 -0.27511 11.7947 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TG46 A0A8P0TG46_CANLF Prenylcysteine oxidase 1 (EC 1.8.3.5) PCYOX1 Canis lupus familiaris (Dog) (Canis familiaris) prenylcysteine catabolic process [GO:0030328] lysosome [GO:0005764] prenylcysteine oxidase activity [GO:0001735] VFEESSWFIMNM 1 2.4 0.99276 -0.27176 8.4168 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TG55 A0A8P0TG55_CANLF Receptor expression-enhancing protein 4 REEP4 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGLQDSDTEDECWSDT;KDHFFRHEWL;LFMAVETFTDIFISWFPFYY;LVFGMLYPAYAS 4 13.6 1.0027 -0.75644 0 0 0 0 10.2573 0 0 0 0 0 0 4.82487 0 0 0 A0A8P0TG76 A0A8P0TG76_CANLF DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) DCAF10 Canis lupus familiaris (Dog) (Canis familiaris) KFSPTHCQIASGCLSGR;MTNLYGSIHPADSVYLSTRTHGA;SPLRVIRSLY 3 9.5 1.004 -0.83338 0 0 0 0 0 0 0 0 0 0 5.17772 0 8.30223 0 0 A0A8P0TG77 A0A8P0TG77_CANLF Solute carrier family 22 member 4 SLC22A4 SLC22A5 Canis lupus familiaris (Dog) (Canis familiaris) carnitine transport [GO:0015879]; sodium ion transport [GO:0006814] basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] ATP binding [GO:0005524]; transmembrane transporter activity [GO:0022857] EQLEQESCLDGWEF;ESCLDGWEFSQD;GFNGMSVVFLAAT;LSLDTPNLHGDVYV;VLFVTMGMQ;VTTFLGEWGPFQR 6 8.4 1.0032 -1.1213 0 0 0 11.9625 0 9.47464 10.314 0 0 0 0 0 0 0 0 A0A8P0TG83 A0A8P0TG83_CANLF Elongation factor 1-delta EEF1D Canis lupus familiaris (Dog) (Canis familiaris) eukaryotic translation elongation factor 1 complex [GO:0005853] translation elongation factor activity [GO:0003746] AESSYRQRLADA;GGGGGGGA;GGGGGGGG;PDLAVPPPASSQSPLGG;RGAGGGAG 5 6.4 0.94288 0.10094 0 0 0 0 9.17931 0 7.62834 0 0 0 0 0 0 0 9.43202 A0A8P0TGB3 A0A8P0TGB3_CANLF G protein-coupled receptor 108 GPR108 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IMVICYVYF;NSAFGVVLTRCPDFQGE;VLSKAQSKPTVSQ 3 7.4 0.9763 0.046227 0 0 0 0 0 0 6.58102 0 0 0 0 0 0 0 0 A0A8P0TGB8 A0A8P0TGB8_CANLF Histone acetyltransferase (EC 2.3.1.48) KAT5 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] histone acetyltransferase activity [GO:0004402] EVPASAQASGKT;KCLHFTPKDWS;KVGHSQSWVEVSGV;MGLKSESGERPQITINE;VVSPATPVPSETAP 5 11.7 1.001 -0.62839 9.06469 0 0 0 0 0 0 13.3102 0 0 9.33356 0 0 0 0 A0A8P0TGC5 A0A8P0TGC5_CANLF Spalt like transcription factor 4 SALL4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] TASSQGLASFA 1 1.1 0.98118 0.035491 0 0 0 0 0 0 0 0 8.32719 0 0 0 0 0 0 A0A8P0TGD3 A0A8P0TGD3_CANLF MAP3K7 C-terminal like MAP3K7CL Canis lupus familiaris (Dog) (Canis familiaris) AREFEALMEENRTLKL;SLESMQVFKQHCQIAEEYNE 2 25.4 0.93224 0.099261 0 8.99766 0 0 0 0 6.59228 0 0 0 0 0 0 0 0 A0A8P0TGD6 A0A8P0TGD6_CANLF Cysteine and histidine rich 1 CYHR1 Canis lupus familiaris (Dog) (Canis familiaris) zinc ion binding [GO:0008270] PYRTDDFITRLYYETP;YRTDDFITRLYYETPRFTVLNQ 2 7.4 0.93644 0.097266 0 0 0 0 6.97682 0 10.0079 0 0 0 0 0 0 0 0 A0A8P0TGE5 A0A8P0TGE5_CANLF Histone-lysine N-methyltransferase (EC 2.1.1.355) SUV39H1 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] "chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]" histone H3K9 methyltransferase activity [GO:0046974]; zinc ion binding [GO:0008270] CDYKKIREQE;PRAFVYINEYRVGE;YDFEVEYLCDYKK 3 7.8 1.0029 -0.84104 0 0 0 0 10.926 0 0 0 0 0 0 0 0 0 0 A0A8P0TGI5 A0A8P0TGI5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AAPREPQLRSRSA 1 8.1 0.98791 -0.26085 0 0 0 0 0 0 12.0978 0 0 0 0 0 0 0 0 A0A8P0TGK6 A0A8P0TGK6_CANLF Complement C2 (EC 3.4.21.43) (C3/C5 convertase) C2 Canis lupus familiaris (Dog) (Canis familiaris) "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; proteolysis [GO:0006508]" extracellular region [GO:0005576] serine-type endopeptidase activity [GO:0004252] QFLWLFCSHLFSTT 1 1.8 0.93675 0.060938 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.82888 A0A8P0TGQ0 A0A8P0TGQ0_CANLF protein kinase C (EC 2.7.11.13) PKN1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267] AENMIQTYSNGST;FDEEFTGE;FWRDQRGLCALKF;VGACFGSP 4 4.3 1.0016 -1.8072 0 0 0 8.17832 0 0 0 0 0 7.24878 0 0 0 9.1431 0 A0A8P0TGQ1 A0A8P0TGQ1_CANLF small monomeric GTPase (EC 3.6.5.2) RHEBL1 Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LASERCVVSVDVCVS;PYSFIIGVHGYVL;VLVYSVTSLHSF;YVLVYSVTSLHSF 4 22.8 0.98559 -0.42967 0 0 0 0 0 0 6.2636 0 6.54713 0 5.08215 0 9.73364 0 0 A0A8P0TGS0 A0A8P0TGS0_CANLF "Methyltransferase 4, N6-adenosine" METTL4 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] "catalytic activity, acting on a nucleic acid [GO:0140640]; nucleic acid binding [GO:0003676]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]" HHEPCCGENEPTSS;PLLNCRKTYDVI;QDLFSRVVENNSS 3 9.3 0.99412 -0.13178 4.45556 0 0 0 0 0 9.31456 0 9.55336 0 0 0 0 0 0 A0A8P0TGV0 A0A8P0TGV0_CANLF U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676] ATGAHNYTL;DEDVYGEVREEASDDDMEGD;EASDDDMEGD;ELHIQGFNISHTQT;EVREEASDDDME;ILCGAADE;ILTTCAADIQRQRFLHCTEKDLIP;ISHDDLKG;LSYEVVDKDS;PHVKTNLL;VGITEKKAIKRFQIMNEIVYE;VHLIGGENGPVLEVICSRM;YLHEGLSPMERRLVEQLF 13 7.6 0.99723 -3.718 10.0072 10.4329 0 8.62604 7.95693 9.20144 10.456 9.98314 0 8.49641 0 11.4493 4.56426 0 10.9651 A0A8P0TGV4 A0A8P0TGV4_CANLF F-box protein 34 FBXO34 Canis lupus familiaris (Dog) (Canis familiaris) PTPGIAADLNRKWFGISISQ;SEEKSVSADAFVPP;SPLEISKETLRTPMTHHE;TKEKIAFFAAHQCSNRIG;VLDMVARLE 5 10.3 0.98686 -0.38256 0 0 0 0 0 11.4107 6.24696 0 9.10402 0 0 0 7.91904 0 0 A0A8P0TGV6 A0A8P0TGV6_CANLF "SAM domain, SH3 domain and nuclear localization signals 1" SAMSN1 Canis lupus familiaris (Dog) (Canis familiaris) EKEKHQKPKRSS;KLELGTTVPTVLTN 2 5.9 0.9906 -0.53832 8.07943 0 0 0 0 0 0 0 10.4579 0 0 0 0 0 0 A0A8P0TGX1 A0A8P0TGX1_CANLF Peroxidasin like PXDNL Canis lupus familiaris (Dog) (Canis familiaris) response to oxidative stress [GO:0006979] extracellular region [GO:0005576] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] EHTVEFLCEAEGNP;GLHTVLSSGTLRI;LQHITYSHWLPKIL;NTVYFTCRAEGNP;PQDTEVLIGTSTTLE;SDQGEYQCMARNSA;SFSHLDSL;VLEEHTVEFL 8 7.1 1.0025 -1.3573 0 0 20.1326 0 0 0 13.0085 0 0 0 0 0 10.9097 9.01184 0 A0A8P0TGX6 A0A8P0TGX6_CANLF Selenoprotein V SELENOV Canis lupus familiaris (Dog) (Canis familiaris) KKGDGFVDEAR;LEQQFPNCLLFEE;PLPSVTNGFGSTQEPLPDLTP 3 13 0.98532 -0.43644 0 0 0 7.92884 0 0 0 7.47857 0 0 0 9.31431 0 9.29359 0 A0A8P0TH04 A0A8P0TH04_CANLF Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066]; regulation of biological quality [GO:0065008]; regulation of cell cycle [GO:0051726] nucleus [GO:0005634] metal ion binding [GO:0046872] PPPSLPDNGEDLSTDCDFFT;RDGNIIHGR;VGIKVEAADTEQTSEEVG;VRPKLPLLKILQAA;WYSDCSKLTHSLST 5 12.4 1.0031 -0.89365 0 0 4.93565 0 7.76315 0 5.95058 0 0 0 0 3.36303 4.40429 9.05219 0 A0A8P0TH15 A0A8P0TH15_CANLF Family with sequence similarity 13 member B FAM13B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] LDNEVMQQDFVFEDEENN;LELILKRLKEKRV;PASADILERTIRAA;PPVNYSLLKF;SLSNCNSVLANKIF;TNLDNEVMQQ 6 8.3 0.98768 -0.35014 0 6.55994 9.1812 0 9.47417 0 0 0 0 0 0 0 5.85222 0 0 A0A8P0TH17 A0A8P0TH17_CANLF Kinesin family member 21B KIF21B Canis lupus familiaris (Dog) (Canis familiaris) microtubule-based movement [GO:0007018] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777] ACVSPSDRDFM;AEEEEEERDESGCEEEEGREDEDED;CEEEEGREDEDEDSGSEESL;ELENSQRRLQT;GGAKGART;LADLTCEIE;SALDKGIITPV;VEIKEDGVGFSVRDPYY;YNATVLAYGQ 9 6.8 1.0031 -1.9315 0 9.60199 0 0 0 0 10.1831 0 9.79466 0 0 0 9.02713 11.0719 6.36149 A0A8P0TH21 A0A8P0TH21_CANLF Coatomer subunit gamma-2 (Gamma-2-coat protein) COPG2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139] structural molecule activity [GO:0005198] AAAWEEVGDTFEKEE;SSEGDPPG;VLLQRCMMDTDDEVRDRATFYLNVL 3 4.3 1.0035 -1.6528 0 0 0 0 0 12.6405 0 0 0 0 0 0 0 0 8.13299 A0A8P0TH26 A0A8P0TH26_CANLF DNA-directed primase/polymerase protein (EC 2.7.7.102) (EC 2.7.7.7) PRIMPOL Canis lupus familiaris (Dog) (Canis familiaris) error-prone translesion synthesis [GO:0042276] DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887] AASDAAWDDS;IEERASCYERKPLSSVYRPR 2 6.6 0.9893 -0.22634 0 0 0 0 0 0 0 0 0 0 9.36341 0 0 5.99184 0 A0A8P0TH42 A0A8P0TH42_CANLF Alkaline phosphatase (EC 3.1.3.1) ALPL Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]; side of membrane [GO:0098552] alkaline phosphatase activity [GO:0004035]; metal ion binding [GO:0046872] DWYSDNEMPPEAL;YTEKEKDPKYW 2 4.6 0.99615 -0.57096 0 0 0 0 0 0 9.67745 0 0 0 0 0 0 0 0 A0A8P0TH43 A0A8P0TH43_CANLF Ligand dependent nuclear receptor corepressor like LCORL Canis lupus familiaris (Dog) (Canis familiaris) AEQTDVAVCQNESSS;DTSSLISSVTSVPTNPIKLMFLS;EDCEPEELTDWSMDE;LSSQGQSNTEKIE;SFCNLQREAV;WWAASTSNDSL 6 4.7 1.0021 -0.98812 0 7.50787 0 0 0 0 0 7.74839 9.48043 0 10.7266 0 0 0 10.6164 A0A8P0TH45 A0A8P0TH45_CANLF 5'-nucleotidase domain containing 3 NT5DC3 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] FNDKRRPFRK;MFFIGKFLKLIGKT;PEMSLLSC 3 5.6 1.0022 -0.72509 0 12.1669 0 0 0 0 0 12.8525 5.08814 0 0 0 0 0 0 A0A8P0TH64 A0A8P0TH64_CANLF Retinoic acid receptor gamma RARG Canis lupus familiaris (Dog) (Canis familiaris) retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] APSSSPSRVAMYDCMEA;TKGAERAITLKM 2 4.9 0.93299 0.096667 0 8.24864 0 9.69938 9.69194 0 0 0 0 0 0 0 0 0 0 A0A8P0TH65 A0A8P0TH65_CANLF Endoplasmic reticulum oxidoreductase 1 beta ERO1B Canis lupus familiaris (Dog) (Canis familiaris) protein folding in endoplasmic reticulum [GO:0034975] endoplasmic reticulum membrane [GO:0005789] FAD binding [GO:0071949]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972] HCSIKDCHVEPCPES;LSAAGSRPLAS 2 5.5 0.98588 -0.43438 0 0 0 0 0 0 0 0 0 0 0 0 0 8.81153 0 A0A8P0TH69 A0A8P0TH69_CANLF Death domain-associated protein 6 (Daxx) DAXX Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355] "chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; PML body [GO:0016605]" histone binding [GO:0042393] EEEEEEATDSEEEEDLEQ;EGQGDDEEEEEAGQD;HSLGLPRQQLQLMAQDAFRDV;SEEEEDLEQMQEGQGDDEEEEEAGQ;SSLTGRVIEQ;TDDEEDEESEEEEEEEEEEEEE;TTSKPETDDEEDEESEEEEEEEEE 7 13.1 0.97427 0.042139 8.27244 0 9.84959 0 0 7.40378 10.4456 0 6.55637 9.40423 0 0 8.8947 0 0 A0A8P0TH70 A0A8P0TH70_CANLF Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Canis lupus familiaris (Dog) (Canis familiaris) MAPK cascade [GO:0000165] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EQRPAGEPSL;EQRPAGEPSLLSIKQLVRECKEVLK;GLRKLILRLHKL;HVIRLYSKQITIAINVL;LRKLILRLHKL;PLPAAEAEHRASGPSLQ;SPAAAPVP;TQGFDFLQ;VPRCHSDPPNPHL;VSWDELKSMD 10 6.6 1.0041 -1.9924 0 0 4.90766 9.37571 0 6.87713 10.698 0 7.39601 0 0 4.87239 0 7.59917 6.23812 A0A8P0TH76 A0A8P0TH76_CANLF Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein ALKBH6 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] GWGGGTIQ;LFGGLPANHVLVN 2 5.9 1.0033 -1.1044 0 0 7.32894 0 5.93466 0 0 0 0 0 0 0 0 0 0 A0A8P0TH82 A0A8P0TH82_CANLF Gephyrin [Includes: Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E); Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G)] GPHN Canis lupus familiaris (Dog) (Canis familiaris) Mo-molybdopterin cofactor biosynthetic process [GO:0006777] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin molybdotransferase activity [GO:0061599] DTELIRESD;KHPFYTSPAVIMAH;LKQVLDIDLHAQ;SAYKIVPDEIEEI;VGVLTVSDSCFRNLAEDR 5 9.4 1.0018 -0.67524 0 0 0 0 0 0 0 9.87857 0 11.8722 0 0 8.82464 0 5.3265 A0A8P0TH87 A0A8P0TH87_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) ULK2 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; regulation of autophagy [GO:0010506] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EQVPVKKYDMPMGTAGRR;GVLAPPIG 2 2.7 0.97046 0.048313 0 0 0 0 0 0 0 9.172 0 0 0 0 0 0 0 A0A8P0THA6 A0A8P0THA6_CANLF F-actin monooxygenase (EC 1.14.13.225) MICAL2 Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] cytoplasm [GO:0005737]; nucleus [GO:0005634] actin binding [GO:0003779]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497] CESSLQESKQRKDLQDLFS;EPSEAPLSSSSLS;GHLPSGFQTQ;IDLENIVYYKDC;KFCAGSIDH;LDPLDHRNFY;LLCAENVN;PQTARETPPALGKAQE;SQQRKRRAELKQQREEEGTWKEQE;VGQDMMAVCVL;VLEPPEDQENQK 11 9.3 0.99307 -0.16016 9.00501 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0THA7 A0A8P0THA7_CANLF Contactin-1 CNTN1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] IIEGNMEAARAVDL;LEDEGTYE;QTKTILSDDWKDAKTDPP;RIYVQAFPEWVE 4 5.6 0.99449 -0.56234 8.79795 0 8.60459 0 0 0 11.4567 0 0 0 0 0 9.32677 0 0 A0A8P0THC3 A0A8P0THC3_CANLF Leucine rich repeat containing G protein-coupled receptor 6 LGR6 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] protein-hormone receptor activity [GO:0016500] EAVKSVLLVVLPLP;LDTEDTRPRPSVQC;SPLCLPYAPPE 3 4.7 0.98651 -0.45553 0 0 8.97948 0 0 0 9.51578 0 0 0 0 0 0 0 0 A0A8P0THD2 A0A8P0THD2_CANLF Anion exchange protein SLC4A4 Canis lupus familiaris (Dog) (Canis familiaris) basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] AVSPAAERIRFILGEEDDSPA;CACMPPDP;IVLPPGEW;LGDATDNMQGVLESFLG 4 8.4 0.95612 0.050734 0 0 0 0 0 8.45939 0 0 0 0 0 0 0 0 0 A0A8P0THD6 A0A8P0THD6_CANLF Fibroblast growth factor receptor 4 (EC 2.7.10.1) FGFR4 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713] GGDASSTCSSN;LVGLTDLCPWPTE;MLKDNASDKDLAD;TEYAVPWRCGMCPVCSTYSMCLCVC 4 7 0.98649 -0.33204 0 0 0 0 7.30998 0 11.707 8.91672 0 10.0474 0 7.41261 0 0 0 A0A8P0THE1 A0A8P0THE1_CANLF EMAP like 4 EML4 Canis lupus familiaris (Dog) (Canis familiaris) CAQDRQVCMWNS;EPSEDHMEEQS;HIFFWTWSG;ITVLKAALADVLRRLAIS;LAVEFHPTDANTII;VLTGDSGG 6 7.8 1.0033 -1.6937 9.68564 0 0 0 0 5.01618 0 8.67101 0 0 11.67 0 0 11.0404 0 A0A8P0THF2 A0A8P0THF2_CANLF Cystatin domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) cysteine-type endopeptidase inhibitor activity [GO:0004869] YTVPCLGKTSTE 1 7.4 0.99114 0.0027816 0 0 0 0 0 0 0 0 0 0 0 10.7932 0 0 0 A0A8P0THH1 A0A8P0THH1_CANLF ETS transcription factor ELK3 ELK3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] ICWTSNDGEFKLLKAEE;KGLEISAPPLVLSG;SLSPVAPLSP 3 10.6 1.0031 -0.88726 0 8.72792 0 0 0 0 0 0 0 0 0 0 5.45536 0 0 A0A8P0THH8 A0A8P0THH8_CANLF Palmitoyl-protein thioesterase 1 (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) PPT1 Canis lupus familiaris (Dog) (Canis familiaris) palmitoyl hydrolase activity [GO:0098599] AECQCGPTA;EDCSAECQCGP;GGQHQGVYGLPRCPG 3 7.9 1.0027 -0.98576 0 0 0 3.66426 0 0 0 0 7.67709 0 6.14952 0 0 0 0 A0A8P0THH9 A0A8P0THH9_CANLF Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] centrosome [GO:0005813]; microtubule [GO:0005874]; spindle pole [GO:0000922] microtubule binding [GO:0008017] DMLAWINESL;TLEVEYILEWNRSPQ 2 8.3 0.94759 0.080495 0 0 0 9.23527 0 0 0 0 0 0 0 0 0 0 0 A0A8P0THI5 A0A8P0THI5_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CSNK1A1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; membrane-bounded organelle [GO:0043227] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] HQYDYTFDWTMLKQ;VGGKYKLVR 2 6.8 0.98408 -0.25538 0 0 0 0 0 0 0 0 10.9167 0 0 0 9.90099 0 0 A0A8P0THJ4 A0A8P0THJ4_CANLF Nectin cell adhesion molecule 2 NECTIN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AQDVQVRVPSE;DEGNYTCEFATFPSGT;DGKDEEDEEEEEEKAEEGLM;GGGGGGGD;GGGGGGGG;GGGGGGGGDN;HVDATGASRS;LLLLLLLL;PGGGGGGG;PPLLLLLL;PPLLLLLLL;SPPLPLLPPLLLLLLL;SSPPLPLLPPLLLLLLL;VGGTLLVLLLLAGGSLAFILL 14 22.8 1.0035 -1.5947 9.37241 0 0 0 0 5.81152 0 0 6.7807 7.40489 0 0 0 8.31542 6.0638 A0A8P0THL4 A0A8P0THL4_CANLF Nuclear factor 1 NFIC Canis lupus familiaris (Dog) (Canis familiaris) DNA replication [GO:0006260]; positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] PLKDLVSLACDPASQQPGPSWYL;TAIRYPPHLNPQDPLKDL 2 8.6 0.97425 0.046477 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7762 A0A8P0THL8 A0A8P0THL8_CANLF dual-specificity kinase (EC 2.7.12.1) DYRK1B Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712] APASASSLPGAGAQLPP;HVGEANGG;IVDFGSSCQLGQRIYQY;TSPPPPEL 4 7.2 0.99347 -0.075074 0 0 14.5855 7.92404 8.91821 8.72993 10.0109 0 10.931 9.29444 9.29274 0 0 0 14.3731 A0A8P0THL9 A0A8P0THL9_CANLF Intercellular adhesion molecule 3 ICAM3 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell adhesion [GO:0098609] membrane [GO:0016020] integrin binding [GO:0005178] CSGFCNDIQM;GVHTVTVVMNV;GVLAILGVVTTVAALLHV 3 7.1 0.99103 -0.51469 10.1224 0 0 0 0 0 0 0 0 0 0 0 0 0 4.30714 A0A8P0THN4 A0A8P0THN4_CANLF Suppressor of tumorigenicity 7 protein-like ST7L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FPPLTMLNIHENLL;GVFAKAVSMISRTCIE;IEGALNLLQCTWEGTFRMIPYP;LSQWPPSGPP;VLAKYDDIS 5 11 0.98944 -0.30694 0 0 0 0 0 10.0996 0 0 0 0 0 6.95268 0 0 0 A0A8P0THQ0 A0A8P0THQ0_CANLF Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) AFP Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] AKGYQELLEKCSQSENPL;CCSSSYANRRP;HAENDGKP;MKWVVSFFSIFLLNFSESRTMH 4 10.7 1.0024 -0.71612 0 0 0 0 0 8.36212 0 7.02647 0 0 0 0 0 0 0 A0A8P0THR6 A0A8P0THR6_CANLF [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) NDST2 Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] membrane [GO:0016020] [heparan sulfate]-glucosamine N-sulfotransferase activity [GO:0015016]; deacetylase activity [GO:0019213] LDAWSRELLD;LELHRLIL;MLKLWKVVRPARQLELHRLILLLI 3 4 1.002 -1.29 0 5.65074 0 0 8.54361 0 0 0 0 0 9.39176 0 0 0 0 A0A8P0THS3 A0A8P0THS3_CANLF Phosphatase and actin regulator 4 PHACTR4 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266] cytoplasm [GO:0005737]; lamellipodium [GO:0030027] actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542] ELNEFKSSEM;STLGRTRSLPITIE;TTPPTKRKSK 3 5 1.0027 -1.1591 0 0 7.15674 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0THS4 A0A8P0THS4_CANLF Ig-like domain-containing protein LOC485809 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KDGTFNWMSWLLVNL;LETSAHQKDQCRDKNF;STEQRLIFP 3 8.7 0.93116 0.1056 0 0 8.73877 5.21704 0 4.48491 0 0 0 0 0 0 0 0 7.87461 A0A8P0THT8 A0A8P0THT8_CANLF Ras suppressor protein 1 RSU1 Canis lupus familiaris (Dog) (Canis familiaris) EESREKNQPEV;KLVEESREKNQP;LNENSLPGNFFYL 3 10.5 1.0036 -0.80485 0 0 0 0 0 0 0 8.08635 0 0 0 0 0 0 9.42429 A0A8P0THW9 A0A8P0THW9_CANLF SNF2 histone linker PHD RING helicase SHPRH Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleosome [GO:0000786]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] DDDDDPYYYYY;FIPSHYSGGKVKNTETQ;FSEKSFTLMSSESS;KDTDSEYLPSNTSDDDDDP;KGKGQPNINLSSQDHCPATNDS;NYVDIPHSNSEDGRRLRNQKRYMAI;SRNVIESATICHLR;VESSFSGEILEDLGWLQ 8 8.8 0.99219 -0.18475 8.68198 0 13.5807 0 0 0 10.108 7.08778 13.0654 0 0 0 10.245 11.0442 0 A0A8P0THZ2 A0A8P0THZ2_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP11C Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] DKNREELFLRALCLCHTV;EMQKFLGSFFIS;GHMRIENQRKEIEEY;IENQRKEIEEYELLHTLN;IVLKNVRRRSARVH;VTSGLPLF;VVEVQADETFP 7 7.7 0.93648 0.060957 0 5.18031 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0THZ9 A0A8P0THZ9_CANLF UTP18 small subunit processome component UTP18 Canis lupus familiaris (Dog) (Canis familiaris) rRNA processing [GO:0006364] nucleolus [GO:0005730] ALLYRWVLFICFKRQ 1 2.7 0.95134 0.053874 0 0 4.11078 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TI32 A0A8P0TI32_CANLF Neuroendocrine convertase 1 (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) PCSK1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] transport vesicle [GO:0030133] serine-type endopeptidase activity [GO:0004252] DCDCDGYTDSI;HMKQPRVYTSY;QGDDCDCDG 3 3.5 1.0027 -0.73323 0 0 0 0 0 0 0 6.4071 0 0 0 3.71425 0 5.81775 0 A0A8P0TI34 A0A8P0TI34_CANLF Chloride channel accessory 2 CLCA2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] intracellularly calcium-gated chloride channel activity [GO:0005229]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GRSEEEQKWGIS;LPATVEAFVERDS;MFIYNSTQNATASIMFM;NSYTFLLIQANVIVTDWY;SPSISSLAYSI;TATIEPEAADPIVLKLFDN 6 10.9 0.99692 -0.58989 0 8.85406 0 2.60834 0 8.16571 0 9.6328 0 0 0 0 10.1093 0 0 A0A8P0TI36 A0A8P0TI36_CANLF Docking protein 7 DOK7 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase binding [GO:0019901] EPSLCACPPG;ESGPATLHLCNDVLVVARD;KGAAASPPGLL;PGGLLGVTAKTRAV 4 8.8 1.004 -0.82738 0 0 0 0 7.88448 0 0 6.77492 0 0 0 0 0 8.3713 0 A0A8P0TI37 A0A8P0TI37_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) CTGSWAQSVLTQPASVSGS;EADYYCSSWDDSL;SGSLGQRVTISCTGIPSN;SVLTQPASVS;SVLTQPASVSG;SVLTQPASVSGS;SVLTQPASVSGSL;SVLTQPASVSGSLG;SVLTQPASVSGSLGQ 9 29.9 0.92731 0.10795 0 0 3.81977 6.41358 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TI42 A0A8P0TI42_CANLF Sister chromatid cohesion protein DCC1 DSCC1 Canis lupus familiaris (Dog) (Canis familiaris) mitotic sister chromatid cohesion [GO:0007064] Ctf18 RFC-like complex [GO:0031390] LAGKRKKAILLARK;LLDQIQASEEEIMTQ;PKLKKLKKLL 3 7.8 0.934 0.060769 0 0 4.48465 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TI46 A0A8P0TI46_CANLF Cyclin B1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle phase transition [GO:0044772] cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538] VPGKVIAKKIPK;YATSKHAKISTL 2 5.9 0.95331 0.05044 0 0 0 0 0 0 0 11.7187 0 0 0 0 0 0 0 A0A8P0TI49 A0A8P0TI49_CANLF heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17) GLCE Canis lupus familiaris (Dog) (Canis familiaris) heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] membrane [GO:0016020] heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464] CIHCKYFKFDDD;PTKIMPKKVVRLIAKGK;YFKFDDDLSF 3 4.7 0.98671 -0.38568 0 0 0 0 0 0 0 5.29543 10.1417 8.84746 0 0 0 0 0 A0A8P0TI50 A0A8P0TI50_CANLF Mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39) Canis lupus familiaris (Dog) (Canis familiaris) heme biosynthetic process [GO:0006783]; mitochondrial transmembrane transport [GO:1990542] mitochondrial inner membrane [GO:0005743] "2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]" AGGGGGCE 1 3.2 1.0039 -1.1044 0 0 5.88413 0 0 7.01892 0 0 0 0 0 0 0 6.85087 0 A0A8P0TI51 A0A8P0TI51_CANLF Eukaryotic elongation factor 2 kinase (EC 2.7.11.20) EEF2K Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686] EQYGSSGSPAS;SENSGDSGYPSEK;SGDENMSDVTFDSL;TALEMTDCDEGGEYDGMQD 4 8.4 0.95449 0.04941 0 9.96106 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TI58 A0A8P0TI58_CANLF Uncharacterized protein ITGB4 Canis lupus familiaris (Dog) (Canis familiaris) PGCCMEPGSPMWDSI;WFGPFSFTTVLIIER 2 7.7 0.93088 0.10775 0 0 0 7.68657 0 0 0 8.1166 0 0 0 0 0 0 0 A0A8P0TI62 A0A8P0TI62_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) RLRLWRFLKKLKIE 1 12.1 0.93228 0.060769 0 0 0 4.60911 0 0 0 0 0 0 0 4.97035 0 0 5.45339 A0A8P0TI64 A0A8P0TI64_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] AASPCQSTCCQQGSCQPTNGKDQLC;CDTRSCQPSCSE;CQESCQPSSSAPSGCEP;CSCTACYESG;CVSSCCRPSCSSSSCCGSSSCGS;LVSSCQPSCSESTSCQVNCCEASL;SCSSSSCCGSSSCGSSCC;SSCCGSSSCGSSCC;SSCCGSSSCGSSCCRPSCCPSCCL;SSSCCGSSSCGSSCCRPSCCPSCC;SSSSCCGS;SSSSCCGSSSCGSSCCRPSCCPSCC;VSSCCRPSCSSSSCCGSSSCGSSC 13 42.8 1.0018 -1.262 8.33056 5.21132 7.48398 5.38024 7.39111 0 7.54936 1.87716 0 0 0 0 5.16575 6.63893 6.51976 A0A8P0TI79 A0A8P0TI79_CANLF Cadherin 6 CDH6 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AEALIHPTGLS;DDPTYGNSAKVVYSIL;EEKPVYILRAQAINRR;GLDMFDVVTDQ;GVITVKKLLDFEKKKV;LRGTHCYCD 6 13 1.0021 -0.90983 0 8.9935 4.31462 0 0 0 9.37918 0 7.89779 0 0 0 8.83725 0 0 A0A8P0TI90 A0A8P0TI90_CANLF Stanniocalcin-1 (STC-1) STC1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular calcium ion homeostasis [GO:0006874] extracellular space [GO:0005615] hormone activity [GO:0005179] CGAFACLENSTCDTD;NGAGGGGEAGRWQSQTQK 2 14.2 0.94108 0.10219 9.34361 0 2.5956 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TIA9 A0A8P0TIA9_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) CIT Canis lupus familiaris (Dog) (Canis familiaris) mitotic cytokinesis [GO:0000281] cytoplasm [GO:0005737] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674] AESLSDKQEALDR;EEMRLMMNQLE;EVQVVRERATGD;GIYSLDCDWWS;IVELSEANKLAANSSLF;LEKISHQDHSDKNRLL;MNFQRFLKFPDDPKVS;QEIKEQEYQA;RLMMNQLEEDLV;SLADSDTIAEL;TELEETTAEAEE;TMERRENRLKDDIQ;TPLSQVNKVWDQS;TQRSLLEQDLATYI;TTCTMLEEQVMDLEALNDE;VGFSYSKAL;VPLQYNELKV 17 11 1.0035 -1.0696 8.68626 0 10.7113 7.75729 9.51956 0 0 8.63008 9.81396 5.46362 0 9.7101 0 12.0435 10.385 A0A8P0TIB4 A0A8P0TIB4_CANLF G protein subunit beta 3 GNB3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] DSKLLVSASQDGKLI 1 4.6 0.99757 -0.090495 0 0 0 0 0 0 12.5876 0 0 0 0 0 0 0 0 A0A8P0TIB6 A0A8P0TIB6_CANLF TEA domain transcription factor 4 TEAD4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] ELFERGPSNAFFLVKFWADLNTNI;GGGPGSCF;PAPPWQGRS;PGHPAVSGFWQGALPGQAG 4 7.5 1.0035 -1.1044 0 0 7.66732 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TIC3 A0A8P0TIC3_CANLF Myelin associated glycoprotein MAG Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] IVEMNASVEAIEG;NTPNIVVPPE;NTPNIVVPPEVV;VEMNASVEAIEG;VPPEVVAGSEVE 5 5.4 0.98722 -0.36041 0 0 0 11.33 0 0 8.56247 0 0 0 0 0 8.75819 12.6883 0 A0A8P0TID0 A0A8P0TID0_CANLF Eukaryotic initiation factor 4A-I (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) EIF4A1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] IETFYNTSIEEMPLNVA 1 4.4 0.98438 0.046227 0 0 0 0 0 0 0 7.22275 0 0 0 0 0 0 0 A0A8P0TID5 A0A8P0TID5_CANLF Vesicular glutamate transporter 1 (Solute carrier family 17 member 7) SLC17A7 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836]; sodium ion transport [GO:0006814] chloride channel complex [GO:0034707]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672] chloride channel activity [GO:0005254]; symporter activity [GO:0015293] GCVIFVRILQGLVEGVT;VFYVYGEGSFGIFWYL;VGFSGFAISGFNVNHLDIAPRY;YAIIVANFCRSWTFYL 4 12.7 0.91848 0.10899 0 6.71631 9.72736 0 7.68377 0 0 0 6.48269 0 0 0 8.95128 8.99183 9.25335 A0A8P0TID9 A0A8P0TID9_CANLF Non-selective voltage-gated ion channel VDAC1 (Voltage-dependent anion-selective channel protein 1) LOC102152873 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; pore complex [GO:0046930] porin activity [GO:0015288]; voltage-gated monoatomic anion channel activity [GO:0008308] KTGYKREHINL;VNLAWTAGNSNT;VVGYKTDEFQLHT;YADLGKSARD 4 18 0.99069 -0.26952 0 0 0 0 0 0 0 0 0 0 0 0 0 9.85276 0 A0A8P0TIE4 A0A8P0TIE4_CANLF 60S ribosomal protein L18a RPL18A Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] VLRRQHKPRFTTKRP 1 10.2 0.95146 0.053889 0 0 0 0 0 0 0 0 0 0 0 0 0 4.14967 0 A0A8P0TIF3 A0A8P0TIF3_CANLF REC114 meiotic recombination protein REC114 Canis lupus familiaris (Dog) (Canis familiaris) GAGARGGP;GVSREQALERCC;PGLPQNPEKPGP 3 8.3 0.99331 -0.16504 0 0 0 8.33776 0 0 7.39395 7.09128 11.798 0 0 0 0 0 0 A0A8P0TIF4 A0A8P0TIF4_CANLF Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma PIP5K1C Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol metabolic process [GO:0046488] ATP binding [GO:0005524]; phosphatidylinositol kinase activity [GO:0052742] DAGVEASPAHACAAAEAETTSQA;LQSYRFIKKL 2 5.5 0.97638 0.046444 0 0 0 0 0 0 0 0 0 0 9.84485 0 0 0 0 A0A8P0TIF8 A0A8P0TIF8_CANLF Photoreceptor cadherin (Protocadherin-21) CDHR1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] AGPARWAV;AKDRGSPSFSTTALLKI;LLRLCLGS;TFYGESGP 4 4.9 1.0032 -1.5825 2.6545 0 11.5934 0 0 0 7.95338 0 0 0 0 0 0 0 0 A0A8P0TIG3 A0A8P0TIG3_CANLF ADAMTS like 5 ADAMTSL5 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] SAGCDGLLGSDAH;SGTPRSPSSPLQ 2 4.7 0.99041 -0.19849 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.8936 A0A8P0TIH1 A0A8P0TIH1_CANLF Interferon induced transmembrane protein 10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AAPAPEPSASPPMAPTLFP;TEVNDYYLWSIF;VSIPRRSIAS 3 15 0.99202 -0.27046 12.864 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TIH3 A0A8P0TIH3_CANLF CD99 molecule (Xg blood group) CD99 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GGGGGGGG;KNQQSTNAEQPVQWTLLE;VAAPPRSPL 3 9.4 0.98334 -0.24788 0 0 8.22096 7.86406 0 0 0 0 0 0 8.03513 7.80581 0 0 0 A0A8P0TIH8 A0A8P0TIH8_CANLF "ADP/ATP translocase (ADP,ATP carrier protein)" Canis lupus familiaris (Dog) (Canis familiaris) chromosome segregation [GO:0007059]; mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544] mitochondrial inner membrane [GO:0005743] ATP:ADP antiporter activity [GO:0005471] TVHRTDIMYTGTLNCWRKIGAWSN;VLVLYDETKKF 2 12.7 0.98963 -0.20344 0 0 0 0 0 7.33709 0 0 0 0 0 0 0 0 0 A0A8P0TII5 A0A8P0TII5_CANLF CD244 molecule CD244 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CFCVWRRKKRQSAACRGE 1 5.2 0.97829 0.048313 0 0 0 0 0 0 0 0 6.28405 0 0 0 0 0 0 A0A8P0TII9 A0A8P0TII9_CANLF Embryonic ectoderm development EED Canis lupus familiaris (Dog) (Canis familiaris) DENFYTCAWTYDS;GSNRADENFYTCAWTYDS;IIRIINPITM;SNPDLSGDE 4 8.8 0.98482 -0.23871 11.3773 11.4859 0 0 0 0 0 0 11.1751 0 0 12.5878 0 0 0 A0A8P0TIJ9 A0A8P0TIJ9_CANLF BICD cargo adaptor 1 BICD1 Canis lupus familiaris (Dog) (Canis familiaris) cytoskeletal anchor activity [GO:0008093]; dynein complex binding [GO:0070840] EVLQTVDHYKTEIE;FREARLLQDYTELEE;KQQYDELEAEY;MFATRCDEYVTQL;RSKGKLGKSKIGSPKFLVD 5 8.2 0.95369 0.04941 0 0 0 0 0 0 0 0 4.67209 0 0 0 0 0 0 A0A8P0TIK0 A0A8P0TIK0_CANLF Tr-type G domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] ETSKHYVAITDAP 1 5.5 0.93665 0.059846 0 0 0 0 0 0 0 0 0 0 0 0 9.49003 0 0 A0A8P0TIK5 A0A8P0TIK5_CANLF HIC ZBTB transcriptional repressor 1 HIC1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AAGALAGLGGLPGVP;AGLGPPFGG;DNLLNLDHDMVSPAVFRLVL;GGGGGGGG;GVPGPDGKGKLDFPE;LPPLPFQKLEEA;VCGGKFAQQ 7 11.9 1.0017 -1.3169 8.27678 0 0 8.6371 0 10.0673 11.0843 0 0 9.89777 0 0 0 0 0 A0A8P0TIL2 A0A8P0TIL2_CANLF Synapsin II SYN2 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter secretion [GO:0007269] synaptic vesicle [GO:0008021] ATP binding [GO:0005524] APAPAAARKAKVLLV;CFRGKKVLGDYDIKVEQA;SVGSSFFSSLSQAVKQ;YILDCNGIAVGPKQVQAS 4 13.8 0.98686 -0.3577 0 0 10.4582 0 0 0 10.4306 0 0 0 0 0 7.60051 0 8.15254 A0A8P0TIL3 A0A8P0TIL3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) lipid binding [GO:0008289] DQSGIGQTNVLN;PLALPQTRS 2 5.6 0.98746 -0.50201 0 0 8.90355 0 0 0 0 0 0 0 0 0 9.80798 0 0 A0A8P0TIM1 A0A8P0TIM1_CANLF ADP ribosylation factor like GTPase 5C ARL5C Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] EQLTIRTFSC 1 5 1.0001 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1303 0 A0A8P0TIP2 A0A8P0TIP2_CANLF Zinc finger and BTB domain containing 38 ZBTB38 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CVEMNEMFD;DDRRLEPDKASRAV;ETDHMVKFV;FTEILNYIYSSTV;GNQRFLENYPTIGQNG;HCQFCFQSFLYLSTKRNHEQRHIWE;SFLEDLTDR;VEMNEMFDDASDQDST;VLSILNEQRI 9 9.5 1.0038 -1.9683 9.52888 0 10.4961 0 0 9.84312 0 0 0 7.78764 0 8.47326 0 0 7.92232 A0A8P0TIP9 A0A8P0TIP9_CANLF Proteoglycan 4 PRG4 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576] polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044] CCPDYEDFCGRDE;CCPDYEDFCGRDETNL;CNCDYNCQH;ECDCDSDCKKYGKCCPDYEDFCGRD;GYSRDAICNCDYNCQHYM 5 13.5 0.98978 -0.52833 10.1231 0 0 0 0 0 0 6.76075 0 0 0 0 0 0 0 A0A8P0TIR2 A0A8P0TIR2_CANLF Target of rapamycin complex 2 subunit MAPKAP1 (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) MAPKAP1 Canis lupus familiaris (Dog) (Canis familiaris) TORC2 complex [GO:0031932] FKVSMIHRLRFTTDVQLGH;KVTMKEILLKAVKRR;LICWQYTSEGREPKL 3 10.3 0.9514 0.049531 0 0 0 0 0 0 0 0 9.71428 0 0 0 0 0 0 A0A8P0TIS0 A0A8P0TIS0_CANLF Doublesex and mab-3 related transcription factor 2 DMRT2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] DGEDDEDEDEDDDAEDEGDGL;EDEDEDDDAEDEGDGLE;GPSPPSADGDGEDDEDEDEDDDAED;PSADGDGEDDEDEDE;PSADGDGEDDEDEDEDD;PSADGDGEDDEDEDEDDDA;PSADGDGEDDEDEDEDDDAE;SRTPKCARCR 8 17.4 0.93515 0.060859 6.97373 0 10.6532 0 6.42227 5.24131 0 6.28118 5.422 10.6123 0 10.7692 8.9157 0 11.1337 A0A8P0TIT0 A0A8P0TIT0_CANLF Calcium/calmodulin dependent protein kinase II inhibitor 1 CAMK2N1 Canis lupus familiaris (Dog) (Canis familiaris) protein kinase inhibitor activity [GO:0004860] GAHRLGAG 1 1.4 1.0037 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 10.8878 0 A0A8P0TIT7 A0A8P0TIT7_CANLF Lysine demethylase 4D Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] AEGSCPNP;DFEDLERKYWKTRLY;QEFKDFNKYI 3 6.5 1.0032 -1.6696 0 0 0 0 0 0 0 0 0 0 0 0 0 6.91409 9.38271 A0A8P0TIT9 A0A8P0TIT9_CANLF Serine/threonine-protein kinase (EC 2.7.11.1) PIM3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of apoptotic process [GO:0043066] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674] GVLLYDMVCGDI;HLCGPGGV;HLCGPGGVD 3 6.4 1.0033 -1.6232 0 0 0 9.56114 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TIU0 A0A8P0TIU0_CANLF "Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.71)" BCO2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; mitochondrion [GO:0005739] "metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]" AYNMGNSYGP;LDQVYNSV;PLHVSLND;RGQFPEWLSGY 4 7.4 1.0032 -1.9391 0 8.99797 0 0 0 10.6144 0 0 0 0 0 0 8.83181 0 0 A0A8P0TIU2 A0A8P0TIU2_CANLF Pituitary homeobox 1 (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1) PITX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" QELEATFQ;SSGAGGGH 2 3.1 1.0037 -1.1044 0 0 0 0 0 4.49275 0 0 0 0 0 0 0 0 0 A0A8P0TIU9 A0A8P0TIU9_CANLF Tumor protein p53 binding protein 1 TP53BP1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974] nucleus [GO:0005634] AGEEKEEEVE;AMEIETSVISIDSPQK;CDSGSQAVPSPATRSEALSS;DPSCPASVLKCAEALQ;HDIFIPSPSLEE;ITDVYYVDGTEV;LEEQRILDWQPRENPFHN;LSSVLDQEEAMEI;LVSDQQQNFLELWS;PQPPHGHVLHRH;QPSRDVPVE;SFEKKLQDDEPVEIENPPVPPEPVI;VEINDPILGNEKGEPGAA 13 10 1.002 -1.2653 9.41386 11.1859 9.92059 7.86047 10.7303 11.1361 6.40672 10.1497 11.2649 0 9.0484 0 10.8207 10.5154 12.2474 A0A8P0TIW5 A0A8P0TIW5_CANLF Homeobox domain-containing protein IRX1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGERPGVLAAAAAAAAASSG;LAQGSLLNMRS;SAAGPAAY 3 8.4 0.98974 -0.51629 0 0 0 0 0 0 10.3557 0 0 0 0 0 9.98485 0 0 A0A8P0TIY7 A0A8P0TIY7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) PASEDPVSPSTSSCQ 1 15.2 0.93915 0.070023 0 0 9.64174 0 0 0 0 9.43642 0 8.75489 8.84093 0 0 0 9.18319 A0A8P0TIZ2 A0A8P0TIZ2_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LPTWGHKATGPDRPMPQPQ;TEAGSEPSSEPTMA 2 26.6 0.99417 -0.558 0 0 10.515 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TIZ4 A0A8P0TIZ4_CANLF Solute carrier family 47 member 1 SLC47A1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] antiporter activity [GO:0015297]; xenobiotic transmembrane transporter activity [GO:0042910] VGVILQRGILVLLL 1 4.2 0.94239 0.060769 0 0 0 0 0 0 0 0 0 0 0 1.95962 0 0 0 A0A8P0TJ02 A0A8P0TJ02_CANLF "GTP binding protein 3, mitochondrial" GTPBP3 Canis lupus familiaris (Dog) (Canis familiaris) tRNA modification [GO:0006400] GTP binding [GO:0005525]; GTPase activity [GO:0003924] GEDDNLEEGVLERA;HIVVTGPPNAGK;QRRQALRQLD 3 7.5 1.003 -0.8497 0 0 0 0 0 0 9.33869 0 0 0 0 8.64721 0 0 0 A0A8P0TJ19 A0A8P0TJ19_CANLF Cytosolic fatty-acid binding proteins domain-containing protein RBP1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] lipid binding [GO:0008289] ERKRKKRKKKKERLFLCKEKKK;ERKRKKRKKKKERLFLCKEKKKA;KKKKERKRKKRKKKKE;KKKKERKRKKRKKKKERL;KRKKRKKKKERLFL;RKKKKKERKRKKRKK;RKRKKRKKKKERL 7 7.3 0.58744 0.3647 8.43258 0 0 0 7.67165 5.3679 6.96116 0 0 0 8.70089 0 0 0 12.4194 A0A8P0TJ20 A0A8P0TJ20_CANLF TNF superfamily member 10 TNFSF10 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; metal ion binding [GO:0046872]; tumor necrosis factor receptor binding [GO:0005164] IHQRGFYYIYSQTYFRFQEPEE;KEDDIPWDPSDEESMNN;KENDRIFVSVSNEQL;KSARNSCWSKDSE 4 26.3 0.9861 -0.42163 0 0 9.70525 0 0 0 0 3.93112 0 0 0 0 10.5888 0 0 A0A8P0TJ25 A0A8P0TJ25_CANLF DUF4939 domain-containing protein RTL6 Canis lupus familiaris (Dog) (Canis familiaris) SGDPGQLAGFLMQM 1 5.9 0.98338 -0.25628 0 0 0 0 0 0 0 0 0 8.16536 0 0 0 0 0 A0A8P0TJ48 A0A8P0TJ48_CANLF EF-hand domain-containing protein RPTN Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] EQTHQRRDRQTREGEQIHQRQDRQ;YVDFHEYL 2 3.3 1.0034 -1.0631 0 2.93765 0 8.51672 0 6.43005 0 0 0 0 0 0 0 0 0 A0A8P0TJ67 A0A8P0TJ67_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VLSNQEDQKTVTLD;WVNFQDKFQK 2 6.7 0.99453 -0.12306 0 0 0 0 0 0 0 0 0 0 13.4596 0 0 0 0 A0A8P0TJ75 A0A8P0TJ75_CANLF Phospholipase B-like (EC 3.1.1.-) PLBD1 Canis lupus familiaris (Dog) (Canis familiaris) lipid catabolic process [GO:0016042] phospholipase activity [GO:0004620] DMASMKYIMRYNN;FWRHVGYVMTQMDGL;LLAWQRVRVANMMAN;PLLLLLLLAAAVP;TTNSVYNKTLLKL 5 12.6 0.67939 0.30326 0 0 0 7.13484 6.95396 0 5.69599 0 2.66528 0 0 9.55373 7.50462 0 0 A0A8P0TJ87 A0A8P0TJ87_CANLF Shisa family member 6 SHISA6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALRRLLLLLL;CGTCYYRFCCKKRHEKLDQ;LLLLLLLL;LLLLLLLLL;NKYDPEKDKTNFTVYI;RLLLLLLL;RLLLLLLLL;RLLLLLLLLLS;VLDRYRMTKMHSH 9 12.4 0.98657 -0.42771 0 0 0 9.55748 0 0 0 0 0 0 0 0 5.37639 5.24047 0 A0A8P0TJ93 A0A8P0TJ93_CANLF Adenosine deaminase domain containing 2 ADAD2 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] adenosine deaminase activity [GO:0004000]; RNA binding [GO:0003723] IPNTCHSLSLNWS;IPNTCHSLSLNWSLG;LADPCHDP;LMFREDPTAGE;VLAPQPGPGPPFAL 5 9.2 0.98967 -0.51686 10.021 0 0 0 0 0 10.1202 11.2972 8.34948 11.5099 0 0 10.358 0 9.45352 A0A8P0TJA3 A0A8P0TJA3_CANLF Exportin-4 XPO4 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] nucleus [GO:0005634] nuclear export signal receptor activity [GO:0005049] AFGADTEGSQWI;AGEAFYTL;EALCGIAEATQ;GVASREEEEISEL;LFSSFVNCLTHLTCSFGRSAALE;VLQEFSRRENLNAQ 6 7.5 1.0017 -1.4136 10.2002 0 0 11.5736 8.30474 0 0 9.07588 9.46972 0 9.16667 0 0 0 0 A0A8P0TJA9 A0A8P0TJA9_CANLF Protein Wnt WNT10B Canis lupus familiaris (Dog) (Canis familiaris) Wnt signaling pathway [GO:0016055] extracellular region [GO:0005576] signaling receptor binding [GO:0005102] GPGSGPSPGPQDTWEWGGCNHD;KRGFRESAFSFSM;MRIHNNRVGRQVVTENLKRKCKCH;PALEECGSAEGAGPSAV 4 17.1 0.98757 -0.46226 0 9.86002 0 0 0 0 0 0 0 0 7.15826 0 0 0 0 A0A8P0TJB1 A0A8P0TJB1_CANLF Chromosome 28 C10orf90 homolog C28H10orf90 Canis lupus familiaris (Dog) (Canis familiaris) centrosome [GO:0005813]; cytoplasm [GO:0005737] FVKSNWFPAQ;PATPEPPETPD;VEDRAFSDVGVNQ 3 4.6 0.99285 -0.27132 0 0 9.93348 0 0 0 0 0 0 9.19709 0 0 0 0 0 A0A8P0TJC8 A0A8P0TJC8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) VHLLKWLKSKT 1 7.7 0.98095 0.035491 0 0 0 0 0 0 0 0 4.78388 0 0 0 0 0 0 A0A8P0TJE1 A0A8P0TJE1_CANLF Fc mu receptor FCMR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AEDTDSDDYV;LLMKRVIQRRKALSRRARRAAVRMR;TTLALILLALLGLLMKRVIQRRKA;VPTTLALILLALLGLLMKR;VTELTKSDSGIYACG 5 15.6 0.99093 -0.26786 0 0 8.97865 0 0 0 9.641 0 0 9.96824 0 0 0 0 0 A0A8P0TJF2 A0A8P0TJF2_CANLF Small integral membrane protein 8 SMIM8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] KEPPKEKDFQNPG 1 13.4 0.98931 -0.20228 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.72289 A0A8P0TJF8 A0A8P0TJF8_CANLF Uncharacterized protein LOC111093468 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] ACPGPCQPSCGSCSPCQEGCC;ASPCCHCSPCQEGCCM;CCEASPCCHCSPCQEGCCMSVCCK;CCHCSPCQEGCCMSVCC;CEASPCCHCSPCQEGCCMSVCC;EASPCCHCSPC;MCCEASPCCHCSPCQEGCCMS;PMCCEASPCCHC;PMCCEASPCCHCSPCQEGCC;PMCCEASPCCHCSPCQEGCCMS;PSSCQPSC;SPCCHCSPCQEGCC;SPCQEGCCMSVCC 13 20.5 0.4359 0.5194 11.8978 12.0114 7.63118 7.22265 7.10842 8.10816 0 8.16832 11.634 5.70318 10.5994 5.48353 9.18861 4.18166 0 A0A8P0TJG0 A0A8P0TJG0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LWWVTSHVATTNIFDRYVLDIEAHI 1 12.6 0.99217 -0.29502 0 0 0 0 0 0 0 11.2803 0 0 0 0 0 0 0 A0A8P0TJG7 A0A8P0TJG7_CANLF Small glutamine rich tetratricopeptide repeat co-chaperone alpha SGTA Canis lupus familiaris (Dog) (Canis familiaris) AGLLNNPSFMSMHVRDDFGRPQ;EAERLKTEGNEQMKVENFE 2 10.9 0.93255 0.096966 0 0 0 0 9.12096 0 0 0 0 0 0 0 0 0 9.09995 A0A8P0TJH0 A0A8P0TJH0_CANLF CASP2 and RIPK1 domain containing adaptor with death domain CRADD Canis lupus familiaris (Dog) (Canis familiaris) regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] death domain binding [GO:0070513]; protease binding [GO:0002020] WMTGFPPHILNSSPSDRQINQ 1 10.6 0.9928 -0.19388 9.57537 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TJH3 A0A8P0TJH3_CANLF PDZ and pleckstrin homology domains 1 LOC102151511 Canis lupus familiaris (Dog) (Canis familiaris) PSALKSCTSFSPSHKAT;QVEIKNRFFFPT;VGSDISRCP 3 3.2 1.0028 -0.77749 0 0 0 0 0 0 12.0994 0 0 0 0 0 0 0 0 A0A8P0TJK3 A0A8P0TJK3_CANLF Integrin alpha FG-GAP repeat containing 2 ITFG2 Canis lupus familiaris (Dog) (Canis familiaris) NIRAFCAG 1 1.9 0.98946 -0.2632 0 0 0 0 0 0 0 0 0 0 9.7945 0 0 0 0 A0A8P0TJK9 A0A8P0TJK9_CANLF Microtubule associated protein RP/EB family member 3 MAPRE3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] microtubule [GO:0005874] microtubule binding [GO:0008017] LEKERDFYFSKL;VHLRKVKFQAKL 2 9 0.94171 0.10088 0 0 0 4.69371 0 0 0 0 0 7.07307 0 0 0 0 0 A0A8P0TJL6 A0A8P0TJL6_CANLF Leucine rich adaptor protein 1 like LURAP1L Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of canonical NF-kappaB signal transduction [GO:0043123] EPAPLEGDRDPC;GGGGGGGG 2 9.1 0.94658 0.05044 0 0 0 0 0 0 0 9.8644 0 0 0 0 0 0 0 A0A8P0TJM9 A0A8P0TJM9_CANLF Globin domain-containing protein HBE1 Canis lupus familiaris (Dog) (Canis familiaris) hemoglobin complex [GO:0005833] heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ENFKVSLWDP;EVGGEALGRLL;GKVNVDEVGG;TFAKLSELH;VHLTAEEK;VHLTAEEKS;VHLTAEEKSL;VHLTAEEKSLISSMW 8 44.3 0.98901 -0.26139 0 0 0 0 0 0 0 0 0 0 0 9.56634 0 0 0 A0A8P0TJN6 A0A8P0TJN6_CANLF Nicotinamide N-methyltransferase LOC489397 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] methyltransferase activity [GO:0008168] AEKEERLRRTVRRVL;VRRVLKCDVGKERPLEPAVL;YQTYFEPTTYLG 3 16 0.95314 0.05044 0 0 0 0 0 0 11.5274 0 0 0 0 0 0 0 0 A0A8P0TJP1 A0A8P0TJP1_CANLF EF-hand domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914] CSHEESGSGELSSYKQYDSGS;LAQACNKIIGKDY;SSEHRQSS;TETSSGHLKDCKTNKHGS 4 7.2 1.0006 -0.63483 0 9.42217 0 0 10.9816 0 0 0 0 7.38206 0 0 0 0 10.5744 A0A8P0TJP6 A0A8P0TJP6_CANLF N-terminal kinase-like protein (SCY1-like protein 1) SCYL1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] EESTDTAEDSSAADRWDDED;GLETESRQGKAE;IFPHVVHGFLDTNP 3 6.2 0.94756 0.05044 8.16405 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TJP8 A0A8P0TJP8_CANLF Vomeronasal type-1 receptor Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] RPKSTDFIVKNLIVANILV 1 6.4 0.99099 -0.2693 0 0 0 0 0 0 0 9.58402 0 0 0 0 0 0 0 A0A8P0TJP9 A0A8P0TJP9_CANLF adenylate cyclase (EC 4.6.1.1) ADCY8 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] GQQELYSQS;LINFLGAILNILWCDFDKSI;TEQRFMHGHRG;VFYHGQQELYSQSYDA 4 3.9 0.98592 -0.41223 0 0 8.29756 0 10.3682 0 0 0 0 0 0 11.2986 0 0 10.2369 A0A8P0TJQ6 A0A8P0TJQ6_CANLF "Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)" ENOPH1 MASA Canis lupus familiaris (Dog) (Canis familiaris) L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284] cytoplasm [GO:0005737]; nucleus [GO:0005634] "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity [GO:0043715]; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity [GO:0043716]; acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]" DHNHHCGKSFARLLFPPKFFVKR;EDSHLDGAVPIP;HWEEEECQQDVSLLRKQAEED 3 16.5 0.99242 -0.55233 0 0 0 0 0 0 0 0 0 0 0 0 8.37478 9.45992 0 A0A8P0TJR5 A0A8P0TJR5_CANLF "RAB7B, member RAS onco family" RAB7B Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] RQVPQEVAQGWCKEKDIPYFEVSA;YFEVSAKNDI 2 14 0.98988 -0.2175 0 0 0 0 0 0 0 0 9.97585 0 0 0 0 0 6.97085 A0A8P0TJR7 A0A8P0TJR7_CANLF NAC-A/B domain-containing protein NACAD Canis lupus familiaris (Dog) (Canis familiaris) nascent polypeptide-associated complex [GO:0005854] APAGDTHA;EAPGHLEPAT;EAPGHLEPATE;GEAPGGES;GSVADEQELPYTGPPGP;GVQPAQCPAQAPAAG;LGGCERGRRAGEAGGAG;MEAPEHLEPA;PGPRTAPAGDTHAK;QQADQDSPEEDSP;RPEEEEEEEEEEEE;SSPSCSLSLLAPAEGLDVP;VIAKPDVFKSPASDTYVVFGE 13 6.8 1.0032 -1.5574 10.9905 0 10.4082 0 9.64634 9.38288 11.468 10.5754 8.73478 0 0 11.3755 10.8609 10.3972 10.0067 A0A8P0TJT8 A0A8P0TJT8_CANLF Family with sequence similarity 81 member B FAM81B Canis lupus familiaris (Dog) (Canis familiaris) EKHIWGELEKMQNEYQSGFK;THGFRKEESL 2 10.3 1.0026 -0.84524 0 10.6099 0 0 8.74207 0 0 0 4.70399 0 0 3.7761 0 0 0 A0A8P0TJU0 A0A8P0TJU0_CANLF BCAS3 microtubule associated cell migration factor BCAS3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] EGSIETLSNS;PGSPGPIT 2 2.6 0.99978 -0.61146 0 8.40314 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TJU6 A0A8P0TJU6_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) SLEKCLLMSSAH 1 8.8 0.94676 0.05044 0 0 8.42673 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TJU9 A0A8P0TJU9_CANLF Sine oculis binding protein homolog SOBP Canis lupus familiaris (Dog) (Canis familiaris) GIGPPPGG;IPHVNDSKPPNGFSSNGE;LQRHRERHARRRRRRRRRRRGRQ;PVSVQPPAS;SLSPRDSKQGPSKPAD;SPHIHAPSTPTM;VPIPIPIPIPHVNDSK 7 11.1 1.0013 -0.94837 9.1713 8.49125 7.35535 0 4.83885 12.1665 0 12.6236 0 0 0 0 0 0 0 A0A8P0TJV5 A0A8P0TJV5_CANLF Calcyphosine 2 CAPS2 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] AASIISGIRRVRNHCQRNGFLRF;GEMNEYRK 2 10.1 0.97521 0.046453 0 0 0 0 0 0 0 5.47216 0 0 0 0 0 0 0 A0A8P0TJW2 A0A8P0TJW2_CANLF PDZ domain containing 4 PDZD4 Canis lupus familiaris (Dog) (Canis familiaris) DEEDLGIYVGEV;DLQLVDSGTQ;EERSGMTTDDDAVSEMKMGRYWSKE;GPAVAAHPKAAAAPQGSPA;YRTDDEEDL 5 9.3 0.99379 -0.13183 6.65549 0 0 0 9.29386 9.72322 7.59193 0 0 9.2713 6.04998 9.34172 0 0 0 A0A8P0TJW3 A0A8P0TJW3_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) LOC100683481 Canis lupus familiaris (Dog) (Canis familiaris) protein tyrosine phosphatase activity [GO:0004725] QEEPRRTVKH;QRYIQDEQRRLREQPPGERDYLNVG 2 6.1 0.99311 -0.28044 0 0 0 0 0 0 0 7.47889 0 0 0 0 0 0 0 A0A8P0TJW7 A0A8P0TJW7_CANLF WD repeat and FYVE domain containing 1 WDFY1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905] clathrin adaptor activity [GO:0035615] AGISRYSGK;FILLFSRQGKLRLQK;GGGGGGGG;GGGGGGSG;VGVGVGVL 5 10.6 0.99092 -0.20562 0 0 0 0 0 0 0 7.95739 0 0 0 3.65615 0 0 0 A0A8P0TJZ8 A0A8P0TJZ8_CANLF Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) IMPDH1 IMPDH Canis lupus familiaris (Dog) (Canis familiaris) GMP biosynthetic process [GO:0006177] cytoplasm [GO:0005737]; nucleus [GO:0005634] IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] AAAPAPAPGPPGPRRQ;EQGFITDPVVL;GVSSSGGG;SSSGGGGG;TVMMGSLLAATTEAPG;VSSSGGGG 6 7 0.98727 -0.40399 0 0 0 8.75876 0 9.36584 0 0 0 0 0 0 0 0 0 A0A8P0TJZ9 A0A8P0TJZ9_CANLF Putative monooxygenase p33MONOX KIAA1191 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] DMGSIPWKPVIPERKYQHLAKEGET;IGMYRRAFSY 2 12.3 0.98741 -0.47877 0 0 0 0 0 0 10.5185 0 16.317 0 0 0 0 0 0 A0A8P0TK25 A0A8P0TK25_CANLF Sterile alpha motif domain containing 12 SAMD12 Canis lupus familiaris (Dog) (Canis familiaris) KWLKKHCPNQYQIYR 1 8.2 0.95256 0.053874 0 0 0 0 0 0 0 11.1542 0 0 0 0 0 0 0 A0A8P0TK28 A0A8P0TK28_CANLF IQ motif containing N IQCN Canis lupus familiaris (Dog) (Canis familiaris) GTPSTSQRSGTTHKASHVSLYPSS;GVASNPQAPEF;LVEKKVSMEEGDIP;PGALFRGMAA;PQPCPVPTVTIAKT;PQTYPAAAMTKTP;QSLPPGPV;QTVAIRLPCPVSLDTKCHPCLL;SGVAPSLPPG;SLKTQTQAHMEAEVLKA;TEVGPGFSWASVPN;TPGPLRAASMSKMS;VAPSLTQLSVTSGVTPSL;VVASSLSQPAVTSGVA 14 6.2 1.0032 -2.4551 0 0 9.53796 9.0415 0 0 11.0208 9.57954 10.0779 0 0 10.9804 12.9815 10.0999 12.3405 A0A8P0TK62 A0A8P0TK62_CANLF Gamma-aminobutyric acid type A receptor subunit alpha4 GABRA4 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] HVLPLEKKRGKGPVT;VSYATAMDW 2 4.7 0.95089 0.053874 0 0 4.41027 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TK64 A0A8P0TK64_CANLF Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (EC 3.5.1.44) (Isopeptidase TGM2) (Protein-glutamine deamidase TGM2) (Protein-glutamine dopaminyltransferase TGM2) (Protein-glutamine histaminyltransferase TGM2) (Protein-glutamine noradrenalinyltransferase TGM2) (Protein-glutamine serotonyltransferase TGM2) (Tissue transglutaminase) (Transglutaminase-2) TGM2 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] chromosome [GO:0005694]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886] GTP binding [GO:0005525]; metal ion binding [GO:0046872]; peptidase activity [GO:0008233]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810] AWTAVVMDQQDSVLSLQ;CGPVPVRAIKEG;QGRLVVRRGQPFW 3 6.5 0.99182 -0.20886 0 11.5759 0 0 0 0 0 0 0 0 0 0 10.4936 8.18943 0 A0A8P0TK82 A0A8P0TK82_CANLF APC-binding protein EB1 (End-binding protein 1) Canis lupus familiaris (Dog) (Canis familiaris) microtubule binding [GO:0008017] FMSKQYLCLKCTLQ 1 11.5 0.99112 -0.1944 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.1629 A0A8P0TK92 A0A8P0TK92_CANLF Actin like 6B ACTL6B Canis lupus familiaris (Dog) (Canis familiaris) VFDIGSFS;WNTRAKRE 2 4 0.98474 -0.23937 0 0 0 0 0 0 0 0 0 0 0 8.51175 0 0 9.35982 A0A8P0TK94 A0A8P0TK94_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) DVPDGYWKDAFPLILE 1 9.6 0.25806 0.70752 0 0 0 0 0 0 14.5069 0 14.646 0 0 0 0 0 0 A0A8P0TK99 A0A8P0TK99_CANLF Anoctamin ANO2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] protein dimerization activity [GO:0046983] EEEEERAQEHSR;EIGVPKLKKLFR;FVRIHAPWQ;GQDSGLPSG;HGFVNHTLSFF;IGVPKLKKLFRKLK 6 5.7 1.0033 -1.5745 0 5.2507 0 0 0 11.6925 11.7986 0 0 0 0 0 0 0 8.30191 A0A8P0TKA8 A0A8P0TKA8_CANLF "SEC22 homolog A, vesicle trafficking protein" SEC22A Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] endoplasmic reticulum membrane [GO:0005789] LAFSFLDELQ;LWQLFFHVT 2 6.4 1.0024 -0.71655 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.74411 A0A8P0TKA9 A0A8P0TKA9_CANLF Olfactory receptor OR9S25 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SNGNHSKVYFQDFVLEG 1 5.7 0.97671 0.046227 0 6.07675 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TKB1 A0A8P0TKB1_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8B4 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] AKENLFGQNRSSSNGHVVFEKQQLE;ELACMCKT;ISGNTAVEVREEL;LYVSMEVIRLGHSY;RLLLVHGR;VGDQFRTF;YFRMCKFLRYFFYKNFAFTLVHFWF 7 8.9 1.0044 -1.0946 0 0 8.48006 0 0 0 0 9.96062 0 0 0 6.93699 10.5384 0 0 A0A8P0TKC2 A0A8P0TKC2_CANLF Peroxisome proliferator activated receptor delta PPARD Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] CRFQKCVALGMSHN;VFYRCQCTTVETVREL;YKEISVHVF 3 10.2 0.98938 -0.19676 9.07708 0 0 0 0 0 0 0 8.22636 0 0 0 0 0 0 A0A8P0TKC5 A0A8P0TKC5_CANLF Small nuclear ribonucleoprotein U11/U12 subunit 48 SNRNP48 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] AGGSGAAMAAGEPP 1 6.5 0.98301 -0.25209 0 0 0 0 0 0 0 10.928 0 0 0 0 0 0 0 A0A8P0TKD8 A0A8P0TKD8_CANLF IQ motif containing GTPase activating protein 3 IQGAP3 Canis lupus familiaris (Dog) (Canis familiaris) ERFAMDEYSDMVAVAK;VAKVLRTTLA;VGNLLYYRFLNP;VPDLIAPGQP 4 3.3 0.99669 -0.087669 0 0 0 0 0 9.61204 0 0 0 0 0 0 0 9.56512 9.47013 A0A8P0TKE1 A0A8P0TKE1_CANLF DNA repair protein SWI5 homolog (Protein SAE3 homolog) SWI5 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] VPEITSRDPHLA 1 6.8 0.94567 0.05044 0 0 0 0 0 0 11.1944 11.6189 0 0 0 0 0 0 0 A0A8P0TKE5 A0A8P0TKE5_CANLF LIM/homeobox protein Lhx9 LHX9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" CECKLALESELTCFAKDGSIYCKE;DYYRRFSVQRCARCH;GDHFGMKDSLVYCR;LAAKSGGLALPY;PAMLFHGI;TKRMRTSFKHHQLRTM 6 22.4 1.0015 -0.64082 0 0 0 0 0 5.46444 10.0256 8.27039 9.17363 0 0 0 0 0 8.71273 A0A8P0TKG8 A0A8P0TKG8_CANLF Cytochrome P450 (EC 1.14.14.-) CYP2D15 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" ASLGAGTTTRP;VISSLTYGRRFEY 2 4.4 0.98887 -0.26234 0 0 0 0 0 0 0 0 0 0 0 0 0 10.0634 0 A0A8P0TKH5 A0A8P0TKH5_CANLF BCL2 interacting protein 3 like Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] membrane [GO:0016020]; mitochondrial envelope [GO:0005740] identical protein binding [GO:0042802] AEGEKEVDALRK;DWSSRPENIPP;ESGQSSSRASSHCDSPSLQED 3 34.9 0.9942 -0.16345 0 0 0 0 0 7.76653 0 9.49027 0 9.32292 0 0 0 0 0 A0A8P0TKH9 A0A8P0TKH9_CANLF Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Proto-oncogene c-Mos) MOS Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] SEFSPSVD 1 2.3 0.98371 -0.25362 0 0 0 0 0 0 0 0 0 0 0 8.13304 0 0 0 A0A8P0TKI0 A0A8P0TKI0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) AELAKENGSL;EEDERWIMMEAEEEWEEE;GEFKFTHPADLE;GLPNTDHRASQ;ISPTAAVPSPEE;LVPEEDAPVAVVP;SVLDDAPLDYSS;TDVMQEHRFSSA;VKNLSGECQDFRLQP;VPVSEEGTPVLEEAS 10 13.2 0.94805 0.055198 9.17415 12.3112 0 12.4264 7.7488 12.3104 12.1899 4.45582 10.6165 10.3743 9.56365 9.79826 5.19704 5.86587 7.75922 A0A8P0TKJ6 A0A8P0TKJ6_CANLF Exonuclease 3'-5' domain containing 1 EXD1 Canis lupus familiaris (Dog) (Canis familiaris) nucleobase-containing compound metabolic process [GO:0006139] 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] VVLKKVKNVE;VYLFDIFLL 2 3.6 0.99921 -0.61146 0 0 0 0 0 0 0 3.48941 0 0 0 0 0 0 0 A0A8P0TKK0 A0A8P0TKK0_CANLF ADP-ribosylation factor 3 ARF3 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] Golgi apparatus [GO:0005794] GTP binding [GO:0005525]; GTPase activity [GO:0003924] AVTPCTPF;PTLFWGAPETRGPA 2 4.8 0.99291 -0.1489 0 0 0 0 0 0 0 11.2912 0 0 0 4.6565 0 0 0 A0A8P0TKK1 A0A8P0TKK1_CANLF EGF-like domain-containing protein TGFA Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; membrane [GO:0016020] growth factor activity [GO:0008083] PPPAAPPATPPSA;VLIHCCQVRKHCEWCQALLCRHEKP 2 7.3 0.99137 -0.29311 0 0 0 10.5712 0 0 0 0 0 10.8062 0 0 0 0 0 A0A8P0TKK3 A0A8P0TKK3_CANLF RNA recognition motif domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" nucleic acid binding [GO:0003676] EVDEDLEAETKEECEQY 1 13 0.97705 0.046227 0 0 0 5.08581 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TKK5 A0A8P0TKK5_CANLF Solute carrier family 43 member 1 SLC43A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] transmembrane transporter activity [GO:0022857] DHKVTGDRFY;LGWGSLLIMLKEEG;SAVFLCRLAAGMAPTLQQ;SYLFYYRARL;TLTNFLLVGFG 5 9.6 1.0016 -1.3128 0 7.91761 0 8.95364 0 0 0 10.628 7.70439 0 8.99149 9.03058 0 0 0 A0A8P0TKK6 A0A8P0TKK6_CANLF Neurensin 2 NRSN2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020]; transport vesicle [GO:0030133] HVEIFGDEPEQ;LDQRAADYNQALGTC 2 12.8 0.98553 -0.23574 9.70041 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TKL2 A0A8P0TKL2_CANLF Angiopoietin-related protein 4 (Angiopoietin-like protein 4) ANGPTL4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] extracellular region [GO:0005576] ARKKRLPKMAQLVGPA;GATTVAPSGLSLPFSTWDQ;LGGEDTAY;RLPRDCQELFEEGERQ;TWRGRYYPLQ 5 18.2 1.0028 -1.8894 9.14014 0 0 6.14329 7.142 0 0 9.63369 0 0 0 0 0 0 10.3335 A0A8P0TKL8 A0A8P0TKL8_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) NRLTPRHLI 1 3.7 0.99207 -0.27195 0 0 0 0 0 0 0 0 0 0 0 11.145 0 0 0 A0A8P0TKM5 A0A8P0TKM5_CANLF Symplekin scaffold protein SYMPK Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] ARLMATQMTAAGLGPGVE;DLGTPQAEIARNM;GNSALSPLNPGE;LRLAHLPFLFYR;QALPKLIKLNPIVVK;TKPQSFQVI;VIRKYCEDESRTYLGMS 7 8.2 1.0028 -0.72151 0 10.3977 11.0565 0 7.76235 9.86244 0 11.7195 0 10.6151 10.8363 10.6961 0 0 5.2854 A0A8P0TKM7 A0A8P0TKM7_CANLF Chloride channel protein CLCN5 Canis lupus familiaris (Dog) (Canis familiaris) endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; voltage-gated chloride channel activity [GO:0005247] ELISELFNDCGLLD;GPKAGAKP;HEHCCWNSEHVTFEDR 3 4.2 0.91564 0.11177 0 0 0 0 0 0 0 5.97207 0 6.88069 0 5.34359 0 0 0 A0A8P0TKN2 A0A8P0TKN2_CANLF "Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)" FBP1 Canis lupus familiaris (Dog) (Canis familiaris) gluconeogenesis [GO:0006094] "fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; metal ion binding [GO:0046872]" GGGGGRSP;GGVRAAPG;YGGIFLYPANKKSP 3 6.6 0.99117 -0.51304 0 0 0 0 0 11.0851 0 0 0 0 0 0 10.1812 0 9.5255 A0A8P0TKP3 A0A8P0TKP3_CANLF Ubiquitin associated and SH3 domain containing A UBASH3A Canis lupus familiaris (Dog) (Canis familiaris) FQTMYLRPRDHSVHTQVQGYTLHA;PQEYALFLCPTGPLLEKLEEF 2 25.3 0.9711 0.041303 6.63868 0 0 0 7.9851 0 0 0 0 0 0 0 0 0 0 A0A8P0TKQ0 A0A8P0TKQ0_CANLF Keratin-associated protein LOC111093468 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; keratin filament [GO:0045095] CCQQSSCQPSCCNSSPCQ;CCTPVCCKPFCSPCQEGCC;CQPSCCNSSPCQEGC;ETCCEPPCCAPASCL;PCCQQSSCQPSCCNSSPCQEGCC;PSACTSSSWQVDDCQE;PSCCNSSPCQEGCCVSVCC;QPSCCNSSPCQEGCC;SPCQEGCCMSVCC 9 34.3 0.95397 0.04941 0 0 0 0 0 3.61247 0 0 0 0 0 0 0 0 0 A0A8P0TKR3 A0A8P0TKR3_CANLF small monomeric GTPase (EC 3.6.5.2) Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] cytosol [GO:0005829]; lysosomal membrane [GO:0005765] GTP binding [GO:0005525]; GTPase activity [GO:0003924] KHWTINVFPENKMLL 1 10 0.98833 -0.22696 0 0 0 0 0 0 0 0 0 0 0 0 9.91974 0 0 A0A8P0TKR9 A0A8P0TKR9_CANLF transketolase (EC 2.2.1.1) TKTL1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] transferase activity [GO:0016740] DGDTKNSTFSDIFKREHPERFI;LHEALAAA;TRGRTVAFVSTF 3 7.8 0.98964 -0.52968 0 0 0 0 8.02459 0 0 0 0 0 0 0 0 10.1397 0 A0A8P0TKU9 A0A8P0TKU9_CANLF RNA polymerase II subunit I POLR2I Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] DNA-directed RNA polymerase complex [GO:0000428]; nucleus [GO:0005634] DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676] KCGHKEAVFFQSHSARAEV 1 11.7 0.94911 0.050005 0 0 0 0 0 0 10.9696 0 0 0 0 0 0 0 0 A0A8P0TKV8 A0A8P0TKV8_CANLF Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) GABRA1 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] EDGSRLNQYDL;TVILSQVSFWLNRESVP;WKDERLKF 3 7.9 1.0038 -1.0689 0 0 0 0 0 8.36321 3.15497 0 0 0 0 0 0 0 0 A0A8P0TKW0 A0A8P0TKW0_CANLF Coatomer subunit beta' COPB2 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] COPI-coated vesicle membrane [GO:0030663]; Golgi membrane [GO:0000139]; membrane coat [GO:0030117] structural molecule activity [GO:0005198] VAFMSYFLQ;VFNYNTLERVHMFEAH 2 2.9 0.99391 -0.06013 0 0 0 0 0 0 0 0 0 0 7.17083 0 0 0 0 A0A8P0TKW4 A0A8P0TKW4_CANLF Tubulin epsilon and delta complex 1 TEDC1 Canis lupus familiaris (Dog) (Canis familiaris) CHSDRSLGHLSVAETEMLRDPE;PRAPPTASPAPAGSRAP 2 8.9 0.99256 -0.16546 0 0 0 0 0 0 0 0 0 0 0 0 0 7.06329 0 A0A8P0TKX6 A0A8P0TKX6_CANLF "Polycystin 1 like 1, transient receptor potential channel interacting" PKD1L1 Canis lupus familiaris (Dog) (Canis familiaris) cilium [GO:0005929]; membrane [GO:0016020] ALPEDPPPEVGGPDGAPVT;DLSLAASWSQRVMWLQ;GEEGGLDNG;LPGRRAQAVPS;PDTDAWAPLSL;PSRVNACQSRSPL;TDIDITFLA 7 3.5 1.0029 -1.7215 0 0 9.0885 9.0258 0 0 0 14.6657 9.25191 0 0 0 0 0 0 A0A8P0TKX9 A0A8P0TKX9_CANLF Homeobox protein Hox-D13 HOXD13 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" HASLGGFPVEKYMDVSGL;SGEPRHEAYISM 2 8.8 0.93983 0.10237 0 0 0 8.93089 0 0 0 0 11.1689 0 0 0 0 0 0 A0A8P0TKY7 A0A8P0TKY7_CANLF RING-type domain-containing protein RNF223 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] LECSICFS;LKTGNLHC;RVALVTALLLVLFCVVLW 3 14.7 1.002 -1.3034 5.50878 0 0 0 0 0 0 0 0 8.64479 0 0 0 0 0 A0A8P0TKZ2 A0A8P0TKZ2_CANLF Dihydroorotase CAD Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; glutamine metabolic process [GO:0006541]; pyrimidine nucleotide biosynthetic process [GO:0006221] "amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; metal ion binding [GO:0046872]" AQTNYLYLTYWGTTHDLTFRTPHVL;EVAGFGESRC;GDGVGEHPTQALLDI;LPNNMAMALH;LVQDGTEPSALP;PDTDVLYMTRIQKERF;PVETIELTEDR;SVTGGTAAFEPS;TGFKIPKKNILLTIGS;VGYPCVVRPS;VHSGDATL;VIMGEEVEPVG;VLGTPVETIELTEDRRAF 13 7.5 0.99884 -2.978 0 9.40529 0 10.1642 11.8439 0 0 13.2529 12.9867 9.9884 0 0 0 8.4575 0 A0A8P0TL01 A0A8P0TL01_CANLF CAP-Gly domain containing linker protein 3 CLIP3 Canis lupus familiaris (Dog) (Canis familiaris) NALHYAAYFDVPD 1 2.5 0.98705 -0.23498 0 0 0 0 0 0 0 0 0 0 0 0 15.569 0 0 A0A8P0TL05 A0A8P0TL05_CANLF LRAT domain-containing protein PLAAT3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] APFSLSFCSCCCGGC;DPAPFSLSFCSCCCG;ELVGQELPYSL;SCCCGGCQG;SFCSCCCGGC;SFCSCCCGGCQ 6 15.4 1.0023 -0.98675 13.807 0 13.8577 11.2363 0 5.52582 6.85674 13.5641 13.7856 0 0 6.88362 13.2858 13.3569 6.96359 A0A8P0TL10 A0A8P0TL10_CANLF E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) UBE2L3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; transferase activity [GO:0016740] SKITGTSGQSVIGTHT 1 10.1 0.93437 0.067682 0 0 0 0 0 0 0 0 0 8.86821 0 0 0 0 0 A0A8P0TL14 A0A8P0TL14_CANLF Nonsense-mediated mRNA decay factor SMG6 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" nucleus [GO:0005634] LNGDRVRAAKGEKG;RKGGGAGG;RLLRVADNQELQL;RNRLLELLDEGSD 4 3.7 1.0041 -1.1044 0 0 0 0 7.12288 7.31025 0 0 0 0 5.9442 0 0 0 8.17278 A0A8P0TL17 A0A8P0TL17_CANLF cGMP-dependent protein kinase (EC 2.7.11.12) PRKG2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; cGMP binding [GO:0030553]; cGMP-dependent protein kinase activity [GO:0004692] KKKKKKAL;TLKKKKKKKAL;TLKKKKKKKALQ 3 1.3 1.0024 -1.0185 0 0 0 0 0 0 0 0 8.30469 0 0 0 0 6.61884 0 A0A8P0TL41 A0A8P0TL41_CANLF Transmembrane BAX inhibitor motif containing 6 TMBIM6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FQANLYVGLV 1 4.5 0.98597 -0.25839 0 0 0 0 0 0 0 0 0 0 8.61545 0 0 0 0 A0A8P0TL42 A0A8P0TL42_CANLF L-serine deaminase (L-threonine dehydratase) SDSL Canis lupus familiaris (Dog) (Canis familiaris) HPFDHRLIWEGH;VSSGKAGA 2 6.1 0.99675 -0.57634 0 0 0 0 0 0 0 0 0 0 0 0 9.81258 0 0 A0A8P0TL55 A0A8P0TL55_CANLF Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) Canis lupus familiaris (Dog) (Canis familiaris) apical plasma membrane [GO:0016324] zinc ion transmembrane transporter activity [GO:0005385] GGACGPGPG;ISTDYPLAE;PGPGAGAG;SAHSIFEGLALGLQE;VTFFEILAKELEEKSDRL 5 11.3 1.0016 -0.69592 0 0 0 0 8.42761 0 0 6.83832 0 0 0 0 0 11.6527 0 A0A8P0TL67 A0A8P0TL67_CANLF Disintegrin and metalloproteinase domain-containing protein 2 (Fertilin subunit beta) (PH-30) (PH30-beta) ADAM2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] CTPRKCNERGICNNKKNCH;DCETVSNTCCNPATCT;EQCDCGSAEDCETVSNTCCNPA;FLIILSVLIIILVKVYFQRKKWRTE;GATFQGKMCDSHYGGGVALHPRTI;LIPFLIILSVLIIILVKV;MLLTHLCSQSWLSL 7 14.5 0.98139 -0.24894 0 7.29379 0 5.35293 7.55628 7.54234 11.2575 8.92264 0 0 0 0 8.7706 0 0 A0A8P0TL86 A0A8P0TL86_CANLF C2H2-type domain-containing protein KLF18 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677] FIGDQTFPGGQI;METYIGDQTLYG;TMTFIGDQTFPGGQ 3 5.3 0.99421 -0.12417 11.4481 12.515 0 0 10.4253 0 16.3528 12.6665 12.8652 14.0609 14.0104 14.0182 12.3838 12.3692 0 A0A8P0TL90 A0A8P0TL90_CANLF Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) DAD1 Canis lupus familiaris (Dog) (Canis familiaris) oligosaccharyltransferase complex [GO:0008250] AGSLFDFP 1 7.8 1.0041 -1.1044 0 0 0 0 0 0 8.13093 8.07948 0 0 0 0 0 0 0 A0A8P0TL94 A0A8P0TL94_CANLF Biogenesis of lysosomal organelles complex 1 subunit 2 BLOC1S2 Canis lupus familiaris (Dog) (Canis familiaris) LDQINVIEEQVAALEQAAYK;SPPAPPTPLY 2 18.3 0.9944 -0.56139 0 0 0 0 0 0 0 8.45713 0 0 0 0 0 9.31667 0 A0A8P0TL98 A0A8P0TL98_CANLF ATP binding cassette subfamily A member 2 ABCA2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] ACAMESRRLEEMRGMEEEPTHL;CYTRDDFLFVIEHMMPLCMVISW;DPDNVSLQGDLPPLVL;EALRLGPDT;FQTRKDGS;LALLLPQGAC;LEALRLGPDTWES;PSSAYVFLIVI;QYNFLRQPQ;TILLSTHHMDEADLLGDR 10 5.5 1.0037 -2.2334 0 0 5.60905 0 8.92098 0 9.8153 9.00823 0 8.54709 8.27375 0 0 0 9.12629 A0A8P0TL99 A0A8P0TL99_CANLF Migration and invasion inhibitory protein MIIP Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] AGECGCWG;LQDAQQDAPCGTSW 2 6.2 1.0041 -1.1044 0 0 0 0 0 0 0 4.1768 0 0 0 0 6.17259 0 0 A0A8P0TLA1 A0A8P0TLA1_CANLF Thimet oligopeptidase (EC 3.4.24.15) THOP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AMFSGTHVERDFVEA;GLDFDGRINAWDMRYYMNQVEETRY;YPREGKYGHAACFG 3 8.4 0.98715 -0.22903 0 0 0 0 0 0 11.7941 0 0 0 0 0 5.52885 0 0 A0A8P0TLA2 A0A8P0TLA2_CANLF RBR-type E3 ubiquitin transferase (EC 2.3.2.31) ARIH2 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567] ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270] EEDYDPNCEEEEEDE;EFSALQRIEDKGRHNVFM;ENPDIVNQS;NCEEEEEDEDPGD;PSTGAVGG;PTAHPPHHCAV;TLQYTYPY;YTLQYTYPYAYYME 8 13.4 1.0029 -2.5429 9.93353 9.75636 8.37308 0 0 0 6.12294 7.11676 6.51995 8.54786 0 0 9.07698 4.65581 0 A0A8P0TLA3 A0A8P0TLA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ARRRYRGQRGP;SATREGSASATREGSASA 2 18.9 0.98991 -0.22227 6.59904 0 0 0 0 0 0 0 11.9922 0 0 0 0 0 0 A0A8P0TLA4 A0A8P0TLA4_CANLF C2H2-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LSFTQHKRMHIRE;LTLMYTTEFILERNPIN 2 16.6 0.92768 0.10605 0 0 0 0 0 0 0 0 8.96399 0 0 0 0 0 9.86476 A0A8P0TLA5 A0A8P0TLA5_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) AENVPNLGSETGIQ 1 7.7 0.9443 0.061118 0 0 0 0 0 0 0 9.0527 0 0 0 0 0 0 0 A0A8P0TLA8 A0A8P0TLA8_CANLF Immunoglobulin C1-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ERPSENDSSYCLSS;YFSLFLSLFSLSHT 2 12.3 0.94057 0.060964 0 0 8.81381 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TLB0 A0A8P0TLB0_CANLF Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) EIF3D EIF3S7 Canis lupus familiaris (Dog) (Canis familiaris) cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732] eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852] mRNA cap binding [GO:0098808]; translation initiation factor activity [GO:0003743] CCALLAGSEYLKLGYVS;DFPQLMKMRYLE;FSSDEDDEDEEEEEEEEEG;RCEHDGVMTGANGE;RCEHDGVMTGANGEV;SDEDDEDEEEEEEEEEG;TELKNNSYKLARWTCCALLAG;YSLPDGTFSSDEDDEDEEEEEEEE 8 14.9 0.90557 0.12073 12.4394 20.0346 14.1573 12.8981 18.8667 7.70113 12.0308 10.6362 20.0003 20.1956 11.0425 19.9214 20.1592 11.8996 13.9355 A0A8P0TLC1 A0A8P0TLC1_CANLF pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK Canis lupus familiaris (Dog) (Canis familiaris) pyridoxal 5'-phosphate salvage [GO:0009443] pyridoxal kinase activity [GO:0008478] GSDYLIALGSQRTRNPD;PVYKEKVVPVVMDVLHAM;VLNSDELHELYEGLKLN 3 18.2 0.98842 -0.47504 0 0 0 9.56327 0 0 0 0 0 0 0 0 0 0 8.83457 A0A8P0TLD2 A0A8P0TLD2_CANLF Activated RNA polymerase II transcriptional coactivator p15 (SUB1 homolog) Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription initiation by RNA polymerase II [GO:0060261] nucleus [GO:0005634] DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713] VDKKLKRKKQVGP 1 7.8 0.94091 0.059561 0 0 0 0 4.14771 0 0 0 0 0 0 0 0 0 0 A0A8P0TLD7 A0A8P0TLD7_CANLF Fe2OG dioxygenase domain-containing protein ALKBH1 Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] KKYSADHYTPFP;RLLNHAVPRVLPS 2 6.5 0.99007 -0.22308 0 0 0 8.96628 0 0 0 0 0 0 10.5376 0 0 0 0 A0A8P0TLE4 A0A8P0TLE4_CANLF Pinin PNN Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] desmosome [GO:0030057]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677] LSPVRENASALEMENE;SSTSGSSS;VEPDKECKSLSP 3 4.4 0.9832 -0.25182 0 0 0 0 0 0 0 0 0 0 0 9.08122 0 0 0 A0A8P0TLE7 A0A8P0TLE7_CANLF Keratin 3 KRT3 KRT1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; keratin filament [GO:0045095]; plasma membrane [GO:0005886] structural molecule activity [GO:0005198] DAQGKLSDLEEALQQARE;DEINKRTNAENEF;GGFGLGGG;GGGGGGGA;NAENEFVTIK;QISETNVILSMDNNR;SGGRGSSS;SSSGGGGF;TSSSMSSS;TVSVTSSSMSSSMTSRGGFG 10 16.9 0.99404 -0.15211 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.97441 A0A8P0TLG1 A0A8P0TLG1_CANLF Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Receptor-interacting serine/threonine-protein kinase 5) DSTYK Canis lupus familiaris (Dog) (Canis familiaris) anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] CASKDHLWNNVRRGAR;ETLNTMKEELLDD;GDGGGDGD;GGGGDGGG;GGGGGDGG;GGGGGGDGGG;SFPIFFFKVPKLGSE;VLLHRKPKL 8 7.2 1.0029 -1.7437 5.79322 8.66434 7.0864 0 0 0 0 6.897 0 0 0 0 6.59875 0 0 A0A8P0TLG7 A0A8P0TLG7_CANLF Scinderin (Adseverin) SCIN Canis lupus familiaris (Dog) (Canis familiaris) anchoring junction [GO:0070161]; podosome [GO:0002102] actin filament binding [GO:0051015] CYIILYTYPG;ESTAAAIFTVQLDDYL;LLDAWEQIFIWVGKDANEVE 3 6.4 0.99253 -0.28669 0 0 9.47875 0 0 5.77584 0 0 0 0 0 11.2418 0 0 0 A0A8P0TLH2 A0A8P0TLH2_CANLF Aminopeptidase (EC 3.4.11.-) ERAP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] VGYPLAWKFLRENWDKLIQKF;WMDKNFDKIRVWLQ 2 3.7 0.92495 0.10828 0 0 0 0 9.69723 0 0 0 0 5.44002 0 0 0 0 0 A0A8P0TLH4 A0A8P0TLH4_CANLF Large ribosomal subunit protein eL38 (60S ribosomal protein L38) RPL38 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] EGGVNRPETEV;LLTARRKDAKSVKIKKNK 2 24.4 0.94175 0.083804 0 0 0 0 0 0 0 0 7.76944 0 0 0 0 0 9.71915 A0A8P0TLH7 A0A8P0TLH7_CANLF Tetratricopeptide repeat domain 24 TTC24 Canis lupus familiaris (Dog) (Canis familiaris) GAAAACMLKS;KAQGRGHGDQCFNVAL;RNHEALTSFQRAFI 3 7.4 1.0023 -0.74028 0 0 0 0 10.2396 0 6.90099 0 10.956 0 0 0 0 0 0 A0A8P0TLI8 A0A8P0TLI8_CANLF CD84 molecule CD84 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TLQTDKQTNTPTPG;VTVTHQNY 2 6.2 0.86038 0.16437 0 0 0 0 0 0 0 0 0 0 9.70729 0 0 0 0 A0A8P0TLJ7 A0A8P0TLJ7_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) FLT1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; vascular endothelial growth factor receptor activity [GO:0005021] AATLFWLLLTLFIRKLK;GEEILQKKEVTIRDQEAP;KRITWDSRK 3 3.6 1.0015 -0.70967 10.2411 0 12.5406 0 0 0 0 0 0 0 0 0 0 0 8.42303 A0A8P0TLJ8 A0A8P0TLJ8_CANLF PR/SET domain 13 PRDM13 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; methyltransferase activity [GO:0008168] GGGKPGPG 1 1.1 0.99042 -0.26592 0 0 0 0 0 0 0 0 0 0 0 9.51485 0 0 0 A0A8P0TLK5 A0A8P0TLK5_CANLF Prostaglandin E synthase 3 (cPGES) (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) ATP5F1B Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516] cytoplasm [GO:0005737] Hsp90 protein binding [GO:0051879]; prostaglandin-E synthase activity [GO:0050220]; protein-folding chaperone binding [GO:0051087] ALPEGRRRSS;DGADDKCQI;IDPNDSKHKRTDRSILCC;KDWEDDSDEDMSN;NWKDWEDDSDEDMS;SEMMNNMGGDE 6 18.9 1.002 -1.2929 0 0 9.61875 8.39129 0 0 0 0 7.41886 0 0 0 0 0 4.77879 A0A8P0TLL5 A0A8P0TLL5_CANLF Ras association domain family member 3 RASSF3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] FRRIARLFYW;SGELPSCGAA 2 6.8 0.99985 -0.61146 0 0 0 0 0 0 0 0 0 8.88591 0 0 0 0 0 A0A8P0TLL7 A0A8P0TLL7_CANLF adenylate cyclase (EC 4.6.1.1) ADCY6 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] DEAFIRRGGP;GEGGTEIHDPCDSAGV;PEYFVGNMLLS;SSLTLLMAVLVLLTAVLLAFHAAPA 4 5.3 0.99468 -0.15268 0 0 0 0 0 0 0 11.8637 0 11.6997 11.2944 0 0 0 11.3007 A0A8P0TLM3 A0A8P0TLM3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) KGKMKRSTSTTP;TAPSGTKPSSLP 2 9.7 0.98992 -0.26361 0 0 0 0 0 0 0 0 0 0 0 0 0 9.00166 0 A0A8P0TLQ0 A0A8P0TLQ0_CANLF Vang-like protein VANGL2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CFWSDPHRVL;ENSTNNSTGQSRAVI;ESILQHLEFCIT;HERRVRKRRARLV;ISVAFKLLILLL;YHKERWLAKQW;YHKERWLAKQWTLQTTWKPHFPEFL 7 15.3 1.0003 -0.61409 0 0 0 0 6.39216 3.40844 0 0 9.93068 0 0 0 9.82489 0 10.5214 A0A8P0TLQ1 A0A8P0TLQ1_CANLF DIS3-like exonuclease 1 (EC 3.1.13.1) DIS3L Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "3'-5' exonuclease activity [GO:0008408]; RNA binding [GO:0003723]; RNA exonuclease activity, producing 5'-phosphomonoesters [GO:0016896]" DPENEERCI;LVENSISVVPFSE;SFPHQALLRQ;SIYNAAVWYYHHCQDRM;TSTTTGGE 5 6 1.0027 -1.3516 0 0 0 8.09951 9.2943 13.6952 9.75649 0 0 0 0 0 0 0 0 A0A8P0TLS1 A0A8P0TLS1_CANLF NudC domain containing 3 NUDCD3 Canis lupus familiaris (Dog) (Canis familiaris) PLALPKQE 1 2.3 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 7.71466 0 0 A0A8P0TLS5 A0A8P0TLS5_CANLF RNA exonuclease 5 REXO5 Canis lupus familiaris (Dog) (Canis familiaris) exonuclease activity [GO:0004527]; RNA binding [GO:0003723] DAVLVGHSLD;GLEAVILPK;IPCGQWQRM 3 3.9 1.0023 -1.3718 0 10.0786 0 0 0 0 0 0 0 0 0 0 0 0 13.9102 A0A8P0TLT7 A0A8P0TLT7_CANLF Dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109) POMT2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169] GVEGARAVGPDVGAEPAARS;HLPAEVEGILWDTL;IEVINRKFGNRIKVLRSRIRLIHLV;INRKFGNRIKVLRSRIRLIHL;LLGTAYSFYLFHPLAYG;NGLKPKDNEF;NRKFGNRIKVLRSRIRLIHLV;RCTEAAGRWTL 8 12.5 0.99149 -0.27701 6.8254 0 0 12.747 0 0 0 10.0312 7.06253 0 5.48417 0 0 0 12.7321 A0A8P0TLU2 A0A8P0TLU2_CANLF C2 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GGGGGGGG;PGGGGGGCC 2 4.2 1.004 -0.80421 0 0 0 0 0 0 0 0 6.05942 0 0 0 0 0 0 A0A8P0TLW0 A0A8P0TLW0_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GCTSSHFHQQCQRVPLSPH 1 15.2 0.98408 -0.25293 9.43971 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TLX3 A0A8P0TLX3_CANLF Neurexophilin NXPH1 Canis lupus familiaris (Dog) (Canis familiaris) EPRPRAKRRPIVKTGKFKK;EQTQSHVSWLCS;RYDTPEPYSEQDLWDWLRNSTDL 3 21 0.99215 -0.18292 0 0 0 0 0 7.66491 0 0 0 0 0 0 0 12.4379 0 A0A8P0TLX8 A0A8P0TLX8_CANLF Proline-rich protein 3 (MHC class I region proline-rich protein CAT56) PRR3 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] NELLLQATWMNLTNTV 1 6.4 0.96078 0.049233 0 0 0 0 0 0 0 9.29797 0 0 0 0 0 0 0 A0A8P0TLZ1 A0A8P0TLZ1_CANLF Parathyroid hormone-related protein (PTH-rP) (PTHrP) [Cleaved into: Osteostatin] PTHLH Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634] hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428] DEGRYLTQETNKVETYKEQPLK;EQPLKTPGKKKKGKP;KTPGKKKKGKPGKRKE;QETNKVETYKEQPLKTP 4 21.1 0.83696 0.19622 0 0 0 0 0 0 5.13775 10.1443 8.9467 0 0 0 0 10.2662 0 A0A8P0TM00 A0A8P0TM00_CANLF Serine carboxypeptidase 1 SCPEP1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type carboxypeptidase activity [GO:0004185] CTVCLFLTTK;LVMWLQGGPG;TLPVLLWVTRGS 3 21.8 0.99064 -0.26808 7.35641 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TM02 A0A8P0TM02_CANLF BTB/POZ domain-containing protein PRR36 Canis lupus familiaris (Dog) (Canis familiaris) GPAPPLAPRST;PGGAGAGGV;SLGPSGSP;STLSGPDLAGH;VTSFSPDD 5 3.7 1.0031 -2.3469 0 8.93708 7.01458 0 0 0 11.3392 0 0 10.883 0.301939 0 0 0 9.56253 A0A8P0TM09 A0A8P0TM09_CANLF Cysteine-rich DPF motif domain-containing protein 1 CDPF1 Canis lupus familiaris (Dog) (Canis familiaris) DAFPQEIRQDLE;KRPASQPG;SDTPDFSV 3 8.4 1.0024 -0.97242 0 0 0 0 7.76368 0 0 0 0 0 0 0 0 0 9.16148 A0A8P0TM15 A0A8P0TM15_CANLF Src like adaptor 2 SLA2 Canis lupus familiaris (Dog) (Canis familiaris) LDNGWLYI 1 3.3 1.0039 -1.1044 0 0 0 9.67334 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TM17 A0A8P0TM17_CANLF Myosis regulating glycosidase (putative) MYORG Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] membrane [GO:0016020] "hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]" EGALLGCS;IHLRRPSRILLK;LQARYHNTPYKPPAG;SKELKPLLGSAVLGLLL;YDAEVVAIAH 5 8.5 1.0019 -1.288 0 0 7.90485 10.737 9.37171 0 6.52966 0 4.86948 0 7.13515 0 0 0 0 A0A8P0TM26 A0A8P0TM26_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) KSIKDSRDFMTAEFRANRAEIKNQ 1 8.9 0.99198 -0.28923 0 10.1504 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TM29 A0A8P0TM29_CANLF "WW domain binding protein VOPP1 (EGFR-coamplified and overexpressed protein) (Vesicular, overexpressed in cancer, prosurvival protein 1)" VOPP1 Canis lupus familiaris (Dog) (Canis familiaris) late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] CPRARAQEGGAGPGAG;NSPQGSTAYP 2 5.8 0.98841 -0.26447 0 0 0 0 0 0 0 8.47261 0 0 0 0 0 0 0 A0A8P0TM30 A0A8P0TM30_CANLF Zinc finger and SCAN domain containing 18 ZSCAN18 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ACCCFCGGGGAAD;LVCPLTGAAPEE;PVLLEQGCI;QALTQLYELCRQWLQ;QDTSAAGSP;VAQHPENC;VINHRQYHVKEPNAAGR 7 15.3 1.0031 -1.928 0 0 0 0 0 11.5996 13.5878 0 7.79116 0 0 0 0 0 8.79373 A0A8P0TM32 A0A8P0TM32_CANLF tRNA selenocysteine 1-associated protein 1 (tRNA selenocysteine-associated protein 1) TRNAU1AP Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] FISRAFATMGETV;KPVEYSQMYSYSYNQYYQQYQNY;PVEYSQMYSYSY 3 18.8 0.98929 -0.21903 0 0 0 0 0 0 0 0 0 0 0 11.6816 0 0 9.66544 A0A8P0TM39 A0A8P0TM39_CANLF PDZ domain containing 9 PDZD9 Canis lupus familiaris (Dog) (Canis familiaris) VGNLGLGLIIIQHGPYLQIT 1 7.6 0.94871 0.05015 0 0 0 0 0 0 0 0 4.32948 0 0 0 0 0 0 A0A8P0TM40 A0A8P0TM40_CANLF Leiomodin 3 LMOD3 Canis lupus familiaris (Dog) (Canis familiaris) pointed-end actin filament capping [GO:0051694] tropomyosin binding [GO:0005523] ADAEEDEGDEDDEDDDEEDED;ADAEEDEGDEDDEDDDEEDEDD;ADAEEDEGDEDDEDDDEEDEDDE;AEEDEGDEDDEDDDEEDE;AEEDEGDEDDEDDDEEDED;AEEDEGDEDDEDDDEEDEDDED;DAEEDEGDEDDEDDDEEDEDD;DDEDEDEEEEAESEES;EDDEDEDEEEEAESEESVEKPQ;EDEDEEEE;EDEGDEDDEDD;EDEGDEDDEDDDEEDE;EDEGDEDDEDDDEEDEDDEDE;EEDEDDEDEDEEEEAESEE;EEDEDDEDEDEEEEAESEESVEKPQ;EEQKQQQLKEQRKLI;GDEDDEDDDEEDEDDEDED;HKSLMDYMYWQKASRRMLEDERVP;VQEADDADAEEDEGDEDDEDDDEE 19 15 0.79112 0.22218 0 0 7.47776 0 7.66711 7.98476 0 4.95647 0 0 0 0 0 0 0 A0A8P0TM44 A0A8P0TM44_CANLF Zinc finger protein 597 ZNF597 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] ECDESFSDNS;EDDSEHCSDCGENML;EQGHEDDSEHCSDCG;YKCAECGSS 4 9.2 1.0021 -1.3079 7.33655 0 0 0 0 0 0 0 0 0 0 0 8.43709 0 0 A0A8P0TM58 A0A8P0TM58_CANLF Solute carrier family 26 member 10 SLC26A10 Canis lupus familiaris (Dog) (Canis familiaris) inorganic anion transmembrane transport [GO:0098661] membrane [GO:0016020] monoatomic anion transmembrane transporter activity [GO:0008509] ALLTSVPPVFGL;ALTSGAALHVLV;FASGALML;GVTVGIVHVPQGMAFALLT 4 7 0.98744 -0.36603 0 0 11.5119 0 9.93035 0 0 0 0 9.20689 5.84182 0 0 0 0 A0A8P0TM59 A0A8P0TM59_CANLF Zinc finger protein 566 ZNF566 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] membrane [GO:0016020]; nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FLLIKSYTWLLFQESVMFSDV;SIFIPFFFLSFTKKHFFLL 2 7.8 0.93572 0.09765 0 0 0 0 0 5.32557 0 0 0 0 0 0 5.96285 0 0 A0A8P0TM60 A0A8P0TM60_CANLF Large ribosomal subunit protein uL13 (60S ribosomal protein L13a) RPL13A Canis lupus familiaris (Dog) (Canis familiaris) regulation of translation [GO:0006417]; translation [GO:0006412] large ribosomal subunit [GO:0015934] structural constituent of ribosome [GO:0003735] LDRLKVFDG;PAALKVVRLKPTRKFAYLG 2 15.3 0.99713 -0.11162 8.68356 6.85674 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TM61 A0A8P0TM61_CANLF Ras association domain family member 4 RASSF4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ETPQLMRTKSDAACVIQ 1 5.6 0.86532 0.16095 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.6543 A0A8P0TM69 A0A8P0TM69_CANLF EPS8 like 3 EPS8L3 Canis lupus familiaris (Dog) (Canis familiaris) GPSPERSFSKEQVP;LPEPSNQAPSG;LPPPRRTPSPESPERDEEIL;NLLGKLAI;RKEYLQNISSEPTCLQ 5 12.6 1.003 -1.0067 0 0 0 0 12.7636 9.00949 0 0 0 0 0 0 13.3278 0 0 A0A8P0TM83 A0A8P0TM83_CANLF Fibroblast growth factor 2 (Basic fibroblast growth factor) (Heparin-binding growth factor 2) AFG2A SPATA5 Canis lupus familiaris (Dog) (Canis familiaris) animal organ development [GO:0048513]; system development [GO:0048731] extracellular region [GO:0005576]; nucleus [GO:0005634] growth factor activity [GO:0008083] GSGRAARGWGPAGAAARCRAGGWGA 1 8.1 0.97924 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 7.00742 0 A0A8P0TM86 A0A8P0TM86_CANLF Protein FAM76B FAM76B Canis lupus familiaris (Dog) (Canis familiaris) TQRYPFEELSQGQQL 1 4.4 0.98982 -0.21948 0 0 0 9.18292 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TM87 A0A8P0TM87_CANLF Shisa N-terminal domain-containing protein SHISA9 Canis lupus familiaris (Dog) (Canis familiaris) dendritic spine membrane [GO:0032591] FDVMGQWDPPFNCSSGDFIFCCGTC;GEAGEGAGV 2 13 0.99439 -0.081623 0 6.90436 0 0 0 0 0 0 0 11.566 0 0 0 0 0 A0A8P0TM90 A0A8P0TM90_CANLF Protein-serine/threonine kinase (EC 2.7.11.-) PDK1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GKGKGSPA;GVPGQVDFYARFS;PVYNKAAWKHYN;TPSVQLVQSWYIQSLQ;VPGQVDFY 5 11.9 1.0007 -2.766 0 8.77324 0 0 0 0 0 8.89048 11.1813 0 9.70281 0 0 0 0 A0A8P0TM92 A0A8P0TM92_CANLF Ragulator complex protein LAMTOR5 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) LAMTOR5 Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764]; Ragulator complex [GO:0071986] AAPLLLPLIR;GAVPGAPV 2 12.6 1.0033 -0.87518 11.0001 0 0 0 0 0 0 0 0 0 0 0 0 1.97471 0 A0A8P0TMB0 A0A8P0TMB0_CANLF [histone H3]-trimethyl-L-lysine(4) demethylase (EC 1.14.11.67) KDM5B Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] ELKVCLCQKAPAAPMIQ;EMADAFKSDY;EQSVLAHI;GVSPEMAEKEDYI;KLSHSKDMNSFK;LVAEVQAWKECAAN;SCNQWFHQVCVGVSPE;SYSEQEDSEDEDAICPAVS;VGMCFSSFCWHIEDHWSYSINYLHW;VHLNSLPRLE;YGVPGYAAEQLEN 11 10 1.0031 -1.9172 9.52164 0 6.99718 11.448 0 12.7073 8.52466 11.5572 10.9583 9.52137 0 7.87467 4.4955 0 0 A0A8P0TMB9 A0A8P0TMB9_CANLF Sarcoglycan alpha SGCA Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; sarcoglycan complex [GO:0016012] calcium ion binding [GO:0005509] LTDALVTLLVPLLVALLLTLL;LVPLLVALLLTLLLA;PASRFLTSLGGLWE;VTLLVPLLVALLLTLLLA 4 9.6 0.99299 -0.13274 0 0 3.51551 0 4.60745 0 0 0 0 0 0 0 0 0 10.0937 A0A8P0TMC2 A0A8P0TMC2_CANLF Cadherin domain-containing protein CDHR5 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] DEDGEPGGG 1 1.4 1.0034 -0.80421 0 0 0 0 0 0 10.3859 0 0 0 0 0 0 9.96477 0 A0A8P0TMC6 A0A8P0TMC6_CANLF UBZ2-type domain-containing protein FAAP20 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin binding [GO:0043130] GIADLSPDGELP;LGPPHRVPLR;PGGGGRGGP 3 17.8 1.0019 -1.4334 0 0 0 8.26416 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TMC8 A0A8P0TMC8_CANLF TBC1 domain-containing protein C11H9orf152 Canis lupus familiaris (Dog) (Canis familiaris) RRSLSLEEMDPEAEG 1 6.3 0.95151 0.053888 4.01248 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TMD1 A0A8P0TMD1_CANLF Translocation protein SEC63 homolog SEC63 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SFLVKEIFSFLIH 1 3.4 0.99085 -0.27479 0 0 0 0 9.6548 0 0 0 0 0 0 0 0 0 0 A0A8P0TMF1 A0A8P0TMF1_CANLF Glycosylated integral membrane protein 1 GINM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] SPPAPFALRLLLL;TTLKDDGEVSKEQVVL 2 7.4 0.92351 0.10879 0 0 8.2758 0 0 0 0 0 0 0 0 0 0 0 5.47028 A0A8P0TMF8 A0A8P0TMF8_CANLF Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein AOPEP Canis lupus familiaris (Dog) (Canis familiaris) nucleolus [GO:0005730] metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270] DVAAVPGIETFT;EADFRCVGICGHMEYPCR;HKWIRVNRRPHKRKRRE;LDQAVDHCHYHMMHTDL;QFDYYAHCSQA;SAKPTQLREGRASWHYYVTM;TYQLSQQDAEVRHRW 7 13.7 0.98673 0.046227 0 0 0 0 0 0 0 0 8.01056 0 0 0 0 0 0 A0A8P0TMG7 A0A8P0TMG7_CANLF "SH3 domain containing GRB2 like 2, endophilin A1" SH3GL2 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; membrane [GO:0016020] AMRELSEVKDSLDMEV;CFSARARVPRRSAPPRPQP;FFPINYVEILV;FKRPHHPPL;QNLHDKDLREIQHHL 5 12.3 1.001 -0.70584 5.50748 9.83528 8.45389 5.25297 0 0 0 5.49975 0 0 0 0 0 10.2036 0 A0A8P0TMG9 A0A8P0TMG9_CANLF glutamine--fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) GFPT1 Canis lupus familiaris (Dog) (Canis familiaris) glutamine metabolic process [GO:0006541]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] ELTELPVMVELASD;FLESKGYDFESETD;TYMHSEGILAGE 3 6.6 0.93252 0.060832 0 0 0 9.17996 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TMH6 A0A8P0TMH6_CANLF Multifunctional fusion protein [Includes: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin); Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (p60 katanin-like 1)] KATNAL1 KATNA1 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; microtubule severing [GO:0051013]; spermatogenesis [GO:0007283] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; midbody [GO:0030496]; spindle pole [GO:0000922] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; isomerase activity [GO:0016853]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568] AKKGREYALLGNYDS;GLAAAAAGLV;RLLFEMARFYAPTT 3 6.3 0.4472 0.50054 0 0 0 7.83213 0 6.29653 0 0 0 0 0 0 0 0 0 A0A8P0TMH7 A0A8P0TMH7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LYSTTILN 1 6.6 1.0033 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.13937 A0A8P0TMI5 A0A8P0TMI5_CANLF VWFC domain-containing protein DGCR2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] AWQDQHKLW;EDESDEADCPEVTGESRP;GWVTCEDESDEADCP;ILSLLLFMVHRLRQRRRE;KECCKFMCL;TCEDESDEADCPEVTGE;VTVGIALGFPLGPVC 7 12.5 1.0037 -0.8149 7.8573 0 0 0 6.49006 7.16249 0 9.68741 0 0 8.95271 0 8.69672 14.1376 0 A0A8P0TMI9 A0A8P0TMI9_CANLF CCHC NOA-type domain-containing protein TNIP2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of canonical NF-kappaB signal transduction [GO:0043122] cytoplasm [GO:0005737] K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872] EISRLNRQLEERIRACADGRREL;KTSCPELMRKEISRL;LAYKDDFTSERADRERAQ;LEQQILAYKDDFTSERAD 4 12.8 0.98793 -0.40215 0 0 0 0 0 0 0 0 7.67694 0 3.83935 0 0 11.5215 0 A0A8P0TMJ0 A0A8P0TMJ0_CANLF Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; regulation of autophagy [GO:0010506] cytoplasm [GO:0005737] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] AVAPPVSP;DLEHMPSG;YEALFGQPPFASRSFTELEEKI 3 6 0.98946 -0.2632 0 0 0 0 0 0 0 0 9.43279 0 0 0 0 0 0 A0A8P0TMJ5 A0A8P0TMJ5_CANLF Gelsolin (ADF) (Actin-depolymerizing factor) GSN Canis lupus familiaris (Dog) (Canis familiaris) actin filament severing [GO:0051014]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] actin filament binding [GO:0051015] FQVRASSSG;FQVRASSSGATRA;FVLKTPSAA;FVLKTPSAAYL;GGDSAGGH;GQTAPASTRL;LQVLGPKPALPA;LQVLGPKPALPAG;LQVLGPKPALPAGA;LQVLGPKPALPAGAEDT;LRVLRAQPVQVAEGSEPDGF;LTAQLDEELGG;PLERAVAE;PLERAVAEL;PLERAVAELA;PLERAVAELAA;PNEVVVQRLF;QTAPASTRL;QVLGPKPALPAGAEDT;RAGGGGDS;RDPDQTDGPGLGY;SVDPLERAVAELA;SVDPLERAVAELAA;TSRDGGQTAPASTRL;VEIMPKAGALNSNDA;VGAGASEAEKSGAQEL;VLKTPSAAYL 27 19.2 1.0036 -1.5987 2.65961 10.3029 0 0 0 9.93652 0 0 0 0 0 0 0 0 0 A0A8P0TMK2 A0A8P0TMK2_CANLF Neuronal pentraxin receptor NPTXR Canis lupus familiaris (Dog) (Canis familiaris) ERRQQRPRQE;LPLRLRLRLPLRLRLRL;LRLRLPLRLRLRLPLPLG;LRLRLRLRLRLPLPL;LRLRLRLRLRLRLP;LRLRLRLRLRLRLPLPL;LRLRLRLRLRLRLRLPL;LRLRLRLRLRLRLRLPLP;PLPLRLRLRLPLRLRL;PLRLRLRLPLRL;QELRLRLRLRLRLRLR;RLRLRLPLRLRLRLPLPL;RLRLRLRLRLRLRL;RRQRLGRLGRRRRRRRRRRAAAASP 14 10.8 0.98994 -0.22296 0 0 6.7987 0 0 8.28198 8.64216 0 9.19572 6.44001 0 0 7.04625 0 7.36667 A0A8P0TMK3 A0A8P0TMK3_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR52 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] GAVDVCIFETVVIVLLTFLII;GNLTVIFVF;IFVFHCAPLLHHYTTSYFIQTMAY;LTSAYFTGFIVCLLYAP 4 18.6 0.99597 -0.1145 0 8.35957 10.3942 0 8.65517 0 0 10.7651 6.26823 10.3091 10.5529 0 10.7489 0 0 A0A8P0TML0 A0A8P0TML0_CANLF Zinc finger AN1-type containing 4 ZFAND4 Canis lupus familiaris (Dog) (Canis familiaris) HVARMLSGESVET;LVYREGDQ;NAVSSLATLPSADTPISSI;VDSPGKRSDII;YNLYTDEDE 5 8.9 1.0019 -1.4732 0 0 0 3.24569 8.98368 7.22477 8.17707 8.31578 8.11894 0 7.18349 0 7.4596 0 0 A0A8P0TML5 A0A8P0TML5_CANLF Periphilin 1 PPHLN1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of DNA-templated transcription [GO:0045892] DEGRSFSHD;IELFEDSQLTS;NLHEIGERCVE 3 9 0.99126 -0.18161 0 0 0 8.15396 0 0 0 0 9.97556 0 0 0 0 0 0 A0A8P0TML7 A0A8P0TML7_CANLF Ig-like domain-containing protein LOC484343 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] membrane [GO:0016020] carbohydrate binding [GO:0030246] HQLVLHGVKPG;ILDYINVVPNSGPLVSGS;LCLLLVMKILRKK;SISRDNTSALEPQGNS 4 8.2 0.98641 -0.42828 0 0 0 0 0 0 0 9.52802 0 0 0 6.66605 0 5.88621 0 A0A8P0TMM3 A0A8P0TMM3_CANLF Hexosyltransferase (EC 2.4.1.-) B3GNT7 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] AGGGGFLM;LVVVKSIITQHDR;PEAICTPAFLLLFM;PWFQGLEPHFRQFLTYRHCRYFPML 4 14.2 1.0018 -1.2643 0 0 0 0 9.77777 8.34296 9.31845 0 0 0 0 0 10.9284 0 0 A0A8P0TMM5 A0A8P0TMM5_CANLF Tyrosine-protein kinase receptor (EC 2.7.10.1) INSR Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] membrane [GO:0016020] ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] AENNPGRPPPT;CLGNCSEPDDPTKCV;CPERVTDLMRMCWQFN;KGKTNCPATVINGQ;LKWEPYWPPDFRDLLGFMLFYKEA;VTDLMRMCWQFNP 6 6.1 1.0004 -0.61294 9.98684 7.7974 0 0 0 0 9.49317 9.9884 0 0 0 0 11.302 0 10.4555 A0A8P0TMN5 A0A8P0TMN5_CANLF Paired box 4 PAX4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" LPIMPSSVPASH;SRKRGAFVNWG 2 8.8 0.94099 0.085931 9.09579 9.55198 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TMN6 A0A8P0TMN6_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) EADYYCESEVSTG;ESLSKYYAQWFQ;SSVLTQPPSVS;SSVLTQPPSVSVSLG;SSVLTQPPSVSVSLGQ;SVLTQPPSVSVSLG;TDSDHLLLPVLTL 7 21.8 0 2.8737 9.56866 10.4095 10.3888 7.23199 8.21616 0 11.667 0 10.4084 10.1324 9.4157 10.3891 0 7.06878 0 A0A8P0TMS2 A0A8P0TMS2_CANLF Leucine rich melanocyte differentiation associated LRMDA Canis lupus familiaris (Dog) (Canis familiaris) LVQDHFSCCLCHC;VLHKLPNLKFLDARKVTRQEREEAL 2 21.1 0.94243 0.059681 0 0 0 0 0 0 0 6.09927 0 0 0 0 0 0 0 A0A8P0TMS6 A0A8P0TMS6_CANLF Golgin subfamily A conserved domain-containing protein GOLGA2 Canis lupus familiaris (Dog) (Canis familiaris) cis-Golgi network [GO:0005801] AAKKKLREYQQ;CWGEQAEE;ECWGEQAE;EEEQQRLHAET;EQMHRLREEKEHSM;GVALPPLD;NKNNEDLKQ;PENPTAQQIMQ;VGAKKKRK;VGAKKKRKIK 10 8.7 0.99686 -4.6405 0 0 4.12251 12.5364 12.5572 0 0 8.20413 0 0 0 9.06356 9.01195 7.76388 0 A0A8P0TMS9 A0A8P0TMS9_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KPMYIFLAMLGA 1 4.1 0.99364 -0.17602 0 0 12.5609 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TMT2 A0A8P0TMT2_CANLF 7-dehydrocholesterol reductase (7-DHC) (EC 1.3.1.21) (Sterol Delta(7)-reductase) DHCR7 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol biosynthetic process [GO:0006695] endoplasmic reticulum membrane [GO:0005789] "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]" CLRDEHRCANKYGSDW;PAGIVNKYE;YVLDFFWNETWY 3 7.9 0.9877 -0.2242 0 0 0 0 0 0 0 0 0 0 0 0 9.11782 13.0623 0 A0A8P0TMV8 A0A8P0TMV8_CANLF DNA replication ATP-dependent helicase/nuclease (EC 3.1.-.-) (EC 3.6.4.12) DNA2 Canis lupus familiaris (Dog) (Canis familiaris) "DNA repair [GO:0006281]; DNA replication, Okazaki fragment processing [GO:0033567]" mitochondrion [GO:0005739]; nucleus [GO:0005634] "4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; single-stranded DNA helicase activity [GO:0017116]" DLIIDFREPQ;FYADYSENPWMI;LHHLNSEKLIMDLPSE 3 3.9 0.98635 -0.41316 0 0 9.907 0 0 0 0 0 0 0 0 0 4.19842 0 0 A0A8P0TMW9 A0A8P0TMW9_CANLF Deoxyhypusine hydroxylase DOHH Canis lupus familiaris (Dog) (Canis familiaris) AYCLGQMQDSR;LDEARPLFDR;LDEARPLFDRY;SALLKHELAYCL 4 10.5 0.99891 -0.61074 0 8.91985 0 0 0 0 10.4929 0 10.856 0 7.74099 10.3416 10.4068 10.76 0 A0A8P0TMX4 A0A8P0TMX4_CANLF Olfactory receptor LOC119864882 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ALVPLLLLLKR;IVIRGTTALVPLLLLLKRL;SLHEPMYYFLSM;VPLLLLLKRL 4 9.5 0.98506 -0.24078 0 0 0 0 6.87958 0 0 0 0 0 4.11977 0 0 0 0 A0A8P0TMY3 A0A8P0TMY3_CANLF Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22L Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325]; double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] chromosome [GO:0005694]; nucleus [GO:0005634] KVVKKAMK;LQANCDFG;PQVKRLATENLQY;TETALVNSSRVLF;VLQMYINNLYVPDDLF 5 4.9 1.002 -1.2935 0 0 0 11.4058 0 0 0 0 10.2288 0 0 0 0 0 0 A0A8P0TMZ3 A0A8P0TMZ3_CANLF DUF1725 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IHERIKQMWYIYTMEYYSA 1 19.6 0.98692 -0.23175 0 0 0 0 0 0 0 0 8.15775 0 0 0 0 0 10.0925 A0A8P0TN01 A0A8P0TN01_CANLF Zinc finger protein 584 ZNF584 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] VLSTLIRHRKV 1 2.6 0.97947 0.035491 0 0 0 0 0 0 0 0 5.7591 0 0 0 0 0 0 A0A8P0TN02 A0A8P0TN02_CANLF FCH and mu domain containing endocytic adaptor 2 FCHO2 Canis lupus familiaris (Dog) (Canis familiaris) clathrin-coated pit [GO:0005905] EQMKAFWKLS;QLGDPSQCDSNTKDFW;VLYHNMKHGQ 3 13.8 0.95841 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 8.63572 0 0 A0A8P0TN05 A0A8P0TN05_CANLF Collagen type XIV alpha 1 chain COL14A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] AYSKDKESKPAQ;DVNKISGEMQS;GALGPPAI;HPLSVDEGQHKLMWIPVYGGKTEEV;HVFFVDDF;NAFNTKDEVIE;PAIADIVI;PGVPGITGSM;PLTGIFTTEEVPAQQYLEIDEVTTD;SEVVTAVGTTLDSFWTEP;TVSGGTTRHCFYG;YRIVYNNADG 12 9.9 1.0047 -1.1044 0 0 0 0 0 7.78005 0 0 0 0 0 0 0 0 0 A0A8P0TN23 A0A8P0TN23_CANLF 60S ribosomal protein L7a Canis lupus familiaris (Dog) (Canis familiaris) cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723] AEWTLLNFLYL 1 6.2 0.98405 0.035491 0 0 0 0 0 0 5.33292 0 0 0 0 0 0 0 0 A0A8P0TN27 A0A8P0TN27_CANLF VPS37 C-terminal domain-containing protein VPS37B Canis lupus familiaris (Dog) (Canis familiaris) catabolic process [GO:0009056]; protein transport [GO:0015031] ESCRT I complex [GO:0000813]; late endosome membrane [GO:0031902] GGGGGGGG;QKMEETQNVQLNKEMTLASNRSLAE 2 8.6 0.9796 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.68629 A0A8P0TN28 A0A8P0TN28_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] PLTSMQTLLDI 1 5.4 0.98392 0.035491 0 0 0 0 0 0 10.167 0 0 0 0 0 0 0 0 A0A8P0TN33 A0A8P0TN33_CANLF CHCH domain-containing protein LOC119874932 Canis lupus familiaris (Dog) (Canis familiaris) protein import into mitochondrial intermembrane space [GO:0045041] mitochondrial intermembrane space [GO:0005758] protein-disulfide reductase activity [GO:0015035] AMQECMQKYPDLYPQEDEEEEEEKK;DCVDQFRAMQECMQKY;GEQFKSAFSCFHY 3 32.1 0.99305 -0.16778 0 0 0 0 6.1815 0 7.916 0 0 0 0 0 0 0 7.49657 A0A8P0TN42 A0A8P0TN42_CANLF Keratin 75 KRT75 KRT124 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] EFVVLKKD;EIDNLKKQC;EVKAQYEDIANRS;GGFGTRSLHSF;GVGPVNISVVSSSGGTGYS;LQRVRKEEKEQ 6 13.4 0.98963 -0.52899 0 0 8.18095 0 0 0 0 0 0 9.73828 9.9296 0 0 0 0 A0A8P0TN54 A0A8P0TN54_CANLF Insulin receptor substrate 1 IRS1 Canis lupus familiaris (Dog) (Canis familiaris) insulin receptor signaling pathway [GO:0008286] insulin receptor binding [GO:0005158] CLTSKTISFVKLNSEAAAV;GLGTSPALAADEAAAAAD;SPSDGYYGPEDPQ;YLSGPVAARSSPSVRCPPQLQP 4 6 0.99564 -0.1152 0 0 0 0 0 7.94679 0 8.55647 8.68982 0 0 0 0 8.43283 0 A0A8P0TN56 A0A8P0TN56_CANLF Solute carrier family 16 member 11 SLC16A11 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] AAAGAYGLSA 1 2.6 0.99833 -0.61146 0 0 0 0 6.84699 0 0 0 0 0 0 7.31578 0 0 0 A0A8P0TN66 A0A8P0TN66_CANLF Neuronal PAS domain protein 3 NPAS3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] protein dimerization activity [GO:0046983] AAEDGFGALGPMHIKVERYVESE;ACDNDMHCND;FFIRMKSTLTKRG;GAGGGGGG;GAQASSKH;GGGGGGGA;GGGGGGGG;GNACDNDMHCNDDGP;KRGVHIKSSGYKVIHITGRLRLR;PGGGGGGG;SPQGGGGG 11 11.3 1.0026 -1.7729 0 0 0 0 8.79364 3.68381 10.1307 6.55672 0 4.48465 0 8.71966 0 0 0 A0A8P0TN70 A0A8P0TN70_CANLF "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase)" NARS1 Canis lupus familiaris (Dog) (Canis familiaris) asparaginyl-tRNA aminoacylation [GO:0006421] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] DDLCQCYNGV;DVQLNNRHMMIRG;GADNLINE;GVVLATESSVAVYGTL;NIKKMWHREQMKSE 5 10.6 1.0017 -1.2736 0 0 0 0 0 0 11.6112 11.629 0 0 0 0 0 0 0 A0A8P0TN96 A0A8P0TN96_CANLF Transcription factor Jun (Activator protein 1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) JUN Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AAGGGGGG;GGGGGGGG;LASTANMLREQVAQLK;PVSGAGMV;YGAAGLAFPAQ 5 13.4 0.99111 -0.51423 8.49017 0 0 0 0 0 0 0 0 0 0 0 11.8322 0 0 A0A8P0TNA3 A0A8P0TNA3_CANLF Cardiotrophin 1 CTF1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] LNPRALRLLRRL 1 6.1 0.95412 0.05044 0 0 0 0 4.54189 0 0 0 0 0 0 0 0 0 0 A0A8P0TNB7 A0A8P0TNB7_CANLF Uncharacterized protein LOC102152102 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] CGKSFRDSSQLNQ 1 1.6 0.93715 0.069563 0 0 0 0 0 0 0 10.0572 0 0 0 0 0 0 0 A0A8P0TNC5 A0A8P0TNC5_CANLF G-protein coupled receptors family 1 profile domain-containing protein GPR21 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] IVIFVFHCAPLLNH 1 4 0.93843 0.10437 0 0 0 0 8.8751 0 0 0 0 0 0 0 0 0 0 A0A8P0TND1 A0A8P0TND1_CANLF LIM zinc-binding domain-containing protein WTIP Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047] metal ion binding [GO:0046872] PEPGARSP;TIRVVSMDRDYHVECYHCEDCGL;VECYHCEDC;VGAGAGAG;YHCEDCGLQLSGE;YHTDCFTCDS 6 8.7 1.0005 -2.8003 0 0 0 0 0 2.23358 0 5.79036 8.58067 0 0 7.72894 0 0 0 A0A8P0TND4 A0A8P0TND4_CANLF receptor protein-tyrosine kinase (EC 2.7.10.1) DDR1 Canis lupus familiaris (Dog) (Canis familiaris) collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063] membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] CRGRGEGWMFATENVQSWHR;EPVRHALGGSLGDPR;HYAEADIVTLQ;LLLLLLLL;LLLLLLLLL;LLLLLLLLLL;LLLLLLLLLV;LSSLLLLLLLLLLV;RDGHRWMDWRDRWGQELFFLLESQY;SPTAILIGCLVAIILLLL;TAILIGCLVAIILLLLLIIA;TAILIGCLVAIILLLLLIIAL 12 11.5 0.99071 -0.21195 0 3.79608 0 0 10.6095 0 0 0 0 5.64215 0 6.76567 6.11258 9.50635 6.63433 A0A8P0TNE0 A0A8P0TNE0_CANLF Syntaxin binding protein 3 STXBP3 PRPF38B Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] spliceosomal complex [GO:0005681] KEREKERRRSRSID;PGSQVEVTH;VKAGGGCV 3 5 1.0024 -1.3597 0 0 0 0 0 6.60806 0 0 0 0 0 0 0 8.09101 0 A0A8P0TNF4 A0A8P0TNF4_CANLF ZP domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RCGPGRPGGPAGG 1 3 0.9395 0.059598 0 0 0 0 0 0 0 0 0 0 0 0 6.16629 0 0 A0A8P0TNF5 A0A8P0TNF5_CANLF ADAM like decysin 1 ADAMDEC1 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222] EDCDCGSPKECSNPCCEA;EVGEDCDCGSPKECSNPCCE;GEDCDCGSPKECSNPCCE;KCLLQAPIP;LGHVLGMPDIPY;VGRKQGHIR 6 11.1 1.0022 -1.2466 2.83675 0 0 0 5.41132 0 0 0 0 9.26779 0 0 6.66035 0 0 A0A8P0TNG4 A0A8P0TNG4_CANLF Dual specificity phosphatase catalytic domain-containing protein LOC102151298 Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] DVWYSDEDAN;GKRSRHLNDQ;NSVEDSEDWSPN;QRLTPTQK;RYLIDVEGWDPDTAIQ;SWEQKRQPFSNNRTMAL 6 20.5 0.98981 -0.22289 0 0 0 0 0 9.77831 0 0 0 0 0 0 0 0 0 A0A8P0TNG5 A0A8P0TNG5_CANLF Family with sequence similarity 53 member C FAM53C Canis lupus familiaris (Dog) (Canis familiaris) RRFSLSPSL;SPPWFMACSPP;VLSPEPPDP 3 7.5 0.98964 -0.52958 0 0 7.3565 0 0 0 0 0 0 0 0 0 10.1654 0 0 A0A8P0TNH1 A0A8P0TNH1_CANLF TIAM Rac1 associated GEF 2 TIAM2 Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] EKEELSMGELLMHSAVS;ESKTNIVKVI 2 4.4 0.97989 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.65685 A0A8P0TNH8 A0A8P0TNH8_CANLF CD1c molecule CD1C CD1E Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLNGAYQGSDFL;LNRYQDIKEIVKSLIG;TDPAFRSCVHPPHPS 3 10.6 0.86322 0.15357 8.31972 0 9.83395 7.60222 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TNI0 A0A8P0TNI0_CANLF UBA-like domain-containing protein UBALD1 Canis lupus familiaris (Dog) (Canis familiaris) GSVSQSRT 1 3.5 1.0038 -1.1044 0 0 0 0 0 0 8.69178 0 0 0 0 0 0 0 0 A0A8P0TNJ1 A0A8P0TNJ1_CANLF LRAT domain-containing protein PLAAT3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AFLLVLQPEPKVGDLI;ELVGQELPYSL 2 13.9 0.96108 0.049233 0 0 0 0 0 0 9.72146 0 0 0 0 0 0 0 0 A0A8P0TNJ5 A0A8P0TNJ5_CANLF Phosphoglucomutase 2 like 1 PGM2L1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] intramolecular phosphotransferase activity [GO:0016868] QRGFVVGYDT;TAIGQWLRWDKNP;VVAAEMAAYLE 3 5.7 0.99935 -0.61146 0 0 0 0 0 0 0 0 0 0 0 9.36096 0 0 0 A0A8P0TNJ9 A0A8P0TNJ9_CANLF REST corepressor 1 RCOR1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AGGGGMRV;TKTSVMDRH 2 3.7 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 0 9.73691 0 0 0 0 A0A8P0TNL3 A0A8P0TNL3_CANLF Thymine DNA glycosylase TDG Canis lupus familiaris (Dog) (Canis familiaris) "base-excision repair, AP site formation [GO:0006285]" mismatch base pair DNA N-glycosylase activity [GO:0000700] AAYGGAYTENPCNGDPCSFSS;PCNGDPCSFSSSGLTDSGE;SARCAQFPRAQDKV 3 11.3 0.99517 -0.018352 0 0 0 0 0 10.53 0 6.38426 6.29278 0 0 0 0 11.2513 0 A0A8P0TNL7 A0A8P0TNL7_CANLF Homeobox domain-containing protein NKX1-2 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" AEADAGKDASPGDSAR;AGGSPGAPGPAA;GAGGGGGG;GGGGGGGA;GGGGGGGG 5 12.7 0.93417 0.099673 0 0 0 0 0 0 0 0 0 7.27296 0 8.92229 0 0 0 A0A8P0TNL8 A0A8P0TNL8_CANLF Peroxisomal membrane protein 4 E2F1 Canis lupus familiaris (Dog) (Canis familiaris) SRVQGDTYQ;VNALLRKR 2 8.9 1.0016 -1.4107 0 0 3.21607 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TNM2 A0A8P0TNM2_CANLF "LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated" LSM7 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]" nucleus [GO:0005634] RNA binding [GO:0003723] KFQGGREASGILKGFDP;VGANLARKGKLR 2 7.8 0.93304 0.096667 0 0 0 0 0 0 0 0 0 9.49284 0 6.34298 0 0 0 A0A8P0TNM4 A0A8P0TNM4_CANLF Protein yippee-like YPEL1 YPEL Canis lupus familiaris (Dog) (Canis familiaris) LGWKYEHAFESSQKYKEG;SEECPAEM 2 16.9 1.0037 -1.0561 0 0 0 0 0 0 0 0 0 0 0 2.33145 0 7.43079 0 A0A8P0TNM9 A0A8P0TNM9_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LSCTSQPP;SLKTHLYFCAASA 2 13.6 0.99256 -0.16564 0 9.58201 0 0 0 0 0 0 0 9.60004 0 0 0 0 0 A0A8P0TNN1 A0A8P0TNN1_CANLF Sperm-tail PG-rich repeat containing 3 STPG3 Canis lupus familiaris (Dog) (Canis familiaris) LRQRPLVPAQPKAT 1 4.6 0.94002 0.060769 0 0 0 0 0 0 0 0 8.49422 0 0 0 0 0 0 A0A8P0TNP1 A0A8P0TNP1_CANLF Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] DDDDDGDEEDNDMDNNSE;DLSEGDDDDDDGDEEDNDMDN;ENCGGGSFGS;GDDDDDDGDEEDN;SDFDLSEGDDDDDDG;SDFDLSEGDDDDDDGDEEDNDMD 6 8.3 0.9934 -0.064244 0 6.11245 0 0 0 0 7.08481 0 0 0 0 6.94146 0 0 0 A0A8P0TNQ2 A0A8P0TNQ2_CANLF "Spectrin beta, non-erythrocytic 5" SPTBN5 Canis lupus familiaris (Dog) (Canis familiaris) actin binding [GO:0003779] AQVSAHGAHVHHLALQT;CCPDHTEG;DLRGLEAQ;EQTVQRRLAKILLQL;FSRLHQEQTVQRRLAK;GVWAQLHSEE;LQASVGLYQFYQLSNLELTWVAEH;NSRWKSFHGNL;QAWERQEEKLQTVHREQLF;QDLEDGWNFLEFLRRADL;QIRKHKELERD;SLRHKHEELQVEVKAHQ;VLSSVEQMESWL;VQQEGQQLIDSGHFMSLEVAGCL;YYHHFSRLHQEQ 15 5.8 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 0 0 5.12838 0 0 0 A0A8P0TNS2 A0A8P0TNS2_CANLF Raftlin family member 2 RFTN2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] CKSWNEGTLSG;NCKSWNEG;SPQRAAACPRSASRPA;VETKTEFAYEYVLLDF 4 9.5 1.003 -0.78154 0 0 0 0 0 10.8657 0 0 0 0 5.86935 0 0 0 0 A0A8P0TNU9 A0A8P0TNU9_CANLF Mitochondrial intermediate peptidase MIPEP Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] mitochondrion [GO:0005739] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] AERYNIEPSLYCPFFSLGACM;AGQLKCLEELLSHRDLLAKLVG;LVGTNFPNKVEKHL;VKIAHPEPA;VREAAYKIFLYPN 5 12.2 1.0028 -1.5157 0 6.49838 0 9.39536 0 8.11806 0 0 9.27004 0 0 0 0 5.34426 0 A0A8P0TNV7 A0A8P0TNV7_CANLF Small ArfGAP2 SMAP2 Canis lupus familiaris (Dog) (Canis familiaris) GTPase activator activity [GO:0005096] EDNKFCADCQSKGP;GGNGQAAN;SIANSKTSNTLEKDLDLLA 3 10 1.0045 -1.1044 0 0 0 0 0 0 0 0 0 8.19633 0 0 0 0 0 A0A8P0TNW7 A0A8P0TNW7_CANLF Sodium/hydrogen exchanger SLC9A9 Canis lupus familiaris (Dog) (Canis familiaris) regulation of pH [GO:0006885] plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] sodium:proton antiporter activity [GO:0015385] LYVSKLYKQIYVFYLLYV;TDPVTVLAIFHEL 2 5.2 0.99113 -0.27426 0 0 0 0 0 0 0 0 0 8.99704 0 0 0 0 0 A0A8P0TNX4 A0A8P0TNX4_CANLF Uncharacterized protein LOC100855689 Canis lupus familiaris (Dog) (Canis familiaris) gamete generation [GO:0007276] EPITQWKGTVLDQVPI;REPGGVVDG 2 9.7 0.9896 -0.19886 0 4.7259 0 4.03817 0 0 0 11.8269 11.8336 0 0 0 0 0 0 A0A8P0TNX6 A0A8P0TNX6_CANLF Eukaryotic translation initiation factor 4E nuclear import factor 1 EIF4ENIF1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic ribonucleoprotein granule [GO:0036464] DSKRVFGERRRNDS;LVRRIADPRER;RVFGERRR;SSLGSTPHEELERLAGLEQ;TQKASEENLLSSN;VPLVPHVP 6 7 1.0028 -1.4057 8.87719 0 0 0 0 0 0 0 9.8372 0 0 10.2954 9.38213 0 0 A0A8P0TNX7 A0A8P0TNX7_CANLF Uracil phosphoribosyltransferase homolog UPRT Canis lupus familiaris (Dog) (Canis familiaris) GTP binding [GO:0005525]; GTPase activity [GO:0003924] LSEWLEFNLYTLL 1 8.7 0.94145 0.059873 0 0 0 0 0 0 0 9.27048 0 0 0 0 0 0 0 A0A8P0TNZ3 A0A8P0TNZ3_CANLF Lysine-specific demethylase (EC 1.14.11.65) KDM3A Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] FGVCVDCY 1 0.7 1.0041 -1.1044 0 0 0 0 0 0 0 0 0 0 9.16237 0 0 0 0 A0A8P0TNZ4 A0A8P0TNZ4_CANLF Cullin 1 CUL1 Canis lupus familiaris (Dog) (Canis familiaris) protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] cullin-RING ubiquitin ligase complex [GO:0031461] ubiquitin protein ligase binding [GO:0031625] CAYLNRHWVRRECDE;EDRKLLIQAAIVRI;EIFHTEFQNLLDADKNEDL;ELVTNCFKNRYTLQAS;IEDKDVFQKFYAKML;LDQIWDDLRAGIQQVYT;LLDADKNEDLGRMYNLVSRIQDG 7 14.5 0.99316 -0.28389 5.83983 0 6.23278 0 0 0 0 5.18257 8.4494 0 0 0 9.58451 0 8.69512 A0A8P0TNZ8 A0A8P0TNZ8_CANLF RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) SSU72 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397] nucleus [GO:0005634] protein serine/threonine phosphatase activity [GO:0004722] PSPPDTRFYQERGYHAIP 1 8.1 0.98042 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.75499 A0A8P0TP10 A0A8P0TP10_CANLF Coiled-coil domain-containing protein 25 Canis lupus familiaris (Dog) (Canis familiaris) GVDLGRNFFIQHIY 1 7.1 0.98397 -0.25538 0 0 0 0 0 0 10.0721 0 0 0 0 0 0 0 0 A0A8P0TP20 A0A8P0TP20_CANLF Leishmanolysin-like peptidase (EC 3.4.24.-) LMLN Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] FWIDQQKQKRQM;SCWDFCELCPPERDPP;TELNHWEKRLLE;VGVQDQEGVRDADFV;VLYVGALATERCSHEN 5 10.1 1.0026 -0.75889 9.40924 0 0 8.28179 0 0 0 7.62928 0 0 0 0 0 0 0 A0A8P0TP22 A0A8P0TP22_CANLF G-protein coupled receptors family 1 profile domain-containing protein LOC484858 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SNTLMATTYIVFTPFL 1 5.2 0.95733 0.049233 0 0 0 0 0 0 0 0 8.35081 0 0 0 0 0 0 A0A8P0TP46 A0A8P0TP46_CANLF Transmembrane ascorbate-dependent reductase CYB561 (Cytochrome b-561) (Cytochrome b561) CYB561 Canis lupus familiaris (Dog) (Canis familiaris) chromaffin granule membrane [GO:0042584] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] APGSVPVPGPVP;SGGTSGAL 2 5.1 1.0019 -1.2725 0 0 6.78529 0 0 0 0 0 0 12.4307 0 0 0 0 0 A0A8P0TP49 A0A8P0TP49_CANLF Uncharacterized protein LOC100683920 Canis lupus familiaris (Dog) (Canis familiaris) CGRAPQAATALAGAPT;CLFLIWQVQHYWQQ;EIDRCKISYWGNQVQ;HTPMWENQEYIRGKDG;KRHEYRRSLQESWN;LPKLGDQHTRDGS;SEDGEENQ;SLRDPDPTLLPKLGDQHTR 8 6.8 1.0043 -1.092 9.19338 5.95627 0 0 0 0 0 0 10.6379 0 0 0 10.4367 0 9.40716 A0A8P0TP66 A0A8P0TP66_CANLF Olfactory receptor LOC483612 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GAAWSGGLLHSV;VGLLASYMVILY 2 7.9 0.94142 0.10088 0 0 6.93404 0 7.85549 0 0 0 0 0 0 0 0 0 0 A0A8P0TP85 A0A8P0TP85_CANLF Homeobox protein Hox-D8 HOXD8 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] AARCRRGNSGGSGAGHPG;AQELEEDRAEGLT;EFLFNPYLTRKRRIEVSHALALTE;GGGGGGGD;GGGGGGGG;PIFTTQQEAEL 6 13.6 0.94301 0.083804 0 0 0 0 0 0 0 10.0802 6.78999 0 0 0 0 0 0 A0A8P0TP90 A0A8P0TP90_CANLF Zinc finger protein 350 ZNF350 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] HQIIHTGEKPHRCSLCGKA 1 3.6 0.95135 0.049892 0 7.76148 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TP96 A0A8P0TP96_CANLF LIM domain only 4 LMO4 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] DIGTSCYTKSGMILCRNDY;NPLLPDQKVRVM;YHLKCFTCSTCRNR 3 24.1 1.0032 -0.881 8.38871 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TP98 A0A8P0TP98_CANLF Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1) CHEK1 Canis lupus familiaris (Dog) (Canis familiaris) DNA damage checkpoint signaling [GO:0000077] nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LALLHKILV;NQVTVSTTDR;VKIVDMKRAIDCP 3 7 1.0028 -0.98563 10.895 0 0 0 0 16.0846 0 0 0 0 5.10735 0 0 0 0 A0A8P0TPB5 A0A8P0TPB5_CANLF Uridine 5'-monophosphate synthase (EC 2.4.2.10) (EC 4.1.1.23) UMPS Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205] orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] AFKFGDFVLKSGLS;CLIIEDVVTSGSSVLETVEVLQK;EDVVTSGSSVLETVEVLQ;IHLHSVCT;NLCLSADISESRELLQ 5 13.3 0.98985 -0.52737 12.0707 0 11.33 0 0 0 0 0 13.4331 0 0 0 0 0 0 A0A8P0TPC1 A0A8P0TPC1_CANLF Zinc finger and BTB domain containing 1 ZBTB1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] CNESTDNDELEDEPEEPFY;EWGFLCDCC 2 4.6 1.0004 -0.61973 0 0 0 0 9.58564 0 0 0 0 0 0 0 0 0 0 A0A8P0TPC6 A0A8P0TPC6_CANLF Zinc finger PHD-type domain-containing protein PHF19 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] metal ion binding [GO:0046872] AAKAYVPLRAKRR;DSPHRTNQQQCYCYCGGP;GEADGESHSGPRDS;HSGPRDSGLLWCHQPPPQQGGPGKS;QCYRCRQWFHEACTQ 5 13.3 0.99249 -0.035265 6.56602 13.7858 0 0 0 0 6.97373 5.13233 7.83939 0 0 0 0 0 0 A0A8P0TPD2 A0A8P0TPD2_CANLF G protein-coupled receptor 108 GPR108 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AVADWLDARDP;IMVICYVYF;PFQWQWLYQVRIE;PQLLVEGS;RLLLLLLL;VLSKAQSKPTVSQ 6 10.1 1.0023 -0.97088 0 0 0 0 0 8.97114 10.9966 0 0 0 0 0 0 15.4808 0 A0A8P0TPE4 A0A8P0TPE4_CANLF Protein kinase domain-containing protein STK32A Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] FELEEMIL;FPYMNDMNWDAVLQK;PFLVNLWYSFQDEEDM;VSLLKKLL 4 12.3 1.0019 -1.3028 0 0 0 0 0 0 10.3932 0 0 4.85135 0 8.80106 5.59795 0 5.97783 A0A8P0TPE6 A0A8P0TPE6_CANLF RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) WNQGFKNYYDQGYGN 1 12 0.98738 -0.2253 0 0 0 0 0 0 0 0 0 0 0 12.7523 0 0 0 A0A8P0TPE8 A0A8P0TPE8_CANLF protein disulfide-isomerase (EC 5.3.4.1) CRELD1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] calcium ion binding [GO:0005509]; isomerase activity [GO:0016853] DECETQVCPGENEQCENT;EVLESVCSKSDFE;GGSGHCDC;QWLCSDSL 4 11.2 1.003 -2.4319 0 0 0 0 0 4.95275 0 0 9.60064 0 0 0 0 0 0 A0A8P0TPE9 A0A8P0TPE9_CANLF Proline and serine rich 3 Canis lupus familiaris (Dog) (Canis familiaris) VLQLLRVQRAKLRWQKRKV 1 5.3 0.95333 0.04941 0 0 0 0 0 0 0 0 0 0 0 0 0 6.02689 0 A0A8P0TPF8 A0A8P0TPF8_CANLF RCC1 like RCC1L NCF1 Canis lupus familiaris (Dog) (Canis familiaris) GIGRLEDQY;SGALGVPT;YFPWRVTMPGEPV 3 6.3 1.0041 -1.1044 0 0 0 0 0 0 0 8.50958 0 0 0 0 10.1576 0 0 A0A8P0TPH2 A0A8P0TPH2_CANLF "Keratin, type II cytoskeletal 8 (Cytokeratin-8) (Keratin-8)" Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; nuclear matrix [GO:0016363] structural molecule activity [GO:0005198] EFVLFKKDVDEAYM;ETKTMYQIKYEELQ;KAMVVKKIKTRDGKL 3 10.8 1.0023 -0.65741 10.0692 0 10.2143 0 0 0 0 0 0 0 0 0 11.5812 0 0 A0A8P0TPJ2 A0A8P0TPJ2_CANLF non-specific serine/threonine protein kinase (EC 2.7.11.1) SIK2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EKIYREVQIMKM;QYPMDGTQQGSLATQDC;VLYVLVCGALPFDGPTLPI 3 5.2 1.0026 -0.77148 10.2107 0 0 0 0 0 0 0 0 0 0 0 9.93273 0 0 A0A8P0TPK4 A0A8P0TPK4_CANLF Clusterin CLU Canis lupus familiaris (Dog) (Canis familiaris) chromaffin granule [GO:0042583]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ELFQDRFFTREPQD;FQRRPFFNPKFRIA;FTREPQDTYHYSPFSL;HDMFQPFFD;NFHDMFQPFFD;RPFFNPKFRIA;TYHYSPFSL;VFCTIIFLGRMNSRHQKIPNQRKS 8 15 0.99202 -0.29141 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.6711 A0A8P0TPL5 A0A8P0TPL5_CANLF Disintegrin and metalloproteinase domain-containing protein 5-like LOC482849 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] membrane [GO:0016020] metalloendopeptidase activity [GO:0004222] AVVLIKHKKIRE;FQLIFYISLPVLIITA;IPVYKQRQRR;ISLPVLIITAVVLIKHKKIR;ISSFDAKRNPE;QLIFYISLPVLIITAVVLIKHKKIR;SLPVLIITAVVLIKHKKIRE;SYDDPDICYCSGDVCTMS;VVLIKHKKI 9 9.1 0.98749 -0.47876 9.29678 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TPN3 A0A8P0TPN3_CANLF Adhesion G protein-coupled receptor G4 ADGRG4 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166] membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] DFTIVFTDGI;FYCVMKESVREQWQIHF;IRYHLTPFQWYTVCLMWDGVKGR;IVSATSVTHLFSYHQ;KITDASTY;NLGKTFYIRYHLTPF;PEFKLTTLQLKPTPLSI;QEVSSPRMEDTVST;VDHTFEGMAFSIHSYEEGT;VGYKQERLKKTFQKKLL;VSVPAVSSKRVSATPTIL;VTASPFPDIEKLT;YIRYHLTPFQWYT 13 6 1.003 -0.83928 10.3108 8.78761 0 0 7.46989 4.46982 0 13.0811 0 8.76669 0 9.00402 10.3577 9.27235 11.8819 A0A8P0TPN6 A0A8P0TPN6_CANLF Anti-proliferative protein domain-containing protein BTG2 Canis lupus familiaris (Dog) (Canis familiaris) KPSKGSGY;RVPGKSRRVEPCAA 2 8.6 1.0023 -1.3998 8.072 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TPP1 A0A8P0TPP1_CANLF Cystatin E/M CST6 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] cysteine-type endopeptidase inhibitor activity [GO:0004869] AGVKYYLTV;YLTVELGS 2 9.6 1.0037 -1.0692 0 8.30688 0 0 0 0 9.49939 0 0 0 0 0 0 0 0 A0A8P0TPQ0 A0A8P0TPQ0_CANLF Chromosome alignment maintaining phosphoprotein 1 CHAMP1 Canis lupus familiaris (Dog) (Canis familiaris) attachment of mitotic spindle microtubules to kinetochore [GO:0051315] DAGGLGKMIFYQKSAK;ESQKSSRGGSPDL;HMGTIHPEFCDEMDA;IHPEFCDEMDAGGLG;LWKSSFFIEPQK;SQKPVPVP;VLQFTEEKEAFISEEEIAKYMK 7 10.1 1.0045 -2.0115 0 0 0 8.72427 10.4762 10.2844 0 10.0007 9.03919 0 0 0 9.14267 10.162 0 A0A8P0TPQ9 A0A8P0TPQ9_CANLF Endosomal transmembrane epsin interactor 2 ENTREP2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GETAELQESGILDL;LVHSEAHTDPRGL 2 3.5 0.98653 -0.32167 0 0 0 0 0 0 0 0 0 0 0 10.026 9.41149 0 0 A0A8P0TPR3 A0A8P0TPR3_CANLF Ral transcription factor IIi GTF2I Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] AEALGSTE;AVKVPYPVFESNPEFL;IPRLERILLAKERIRFVIKK;KEEWYARITKLRK;KRPRSPGSNSK;LEKILRNKAKIKFIIKKP;LPEGVAFKHPE;MHKMKSTTPANR;PRLEKILRNKAKIKF;RILLAKERIRFVIKK;STVVPVPYEK 11 13.9 1.0028 -1.9044 6.79662 0 0 0 0 0 0 0 0 6.33153 9.05528 4.36233 5.77821 9.94206 9.42595 A0A8P0TPR7 A0A8P0TPR7_CANLF Spermatosis associated 9 SPATA9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ETIRQNRKENENL;GADCAAPSLPRTVRF;VALAKINRGTLIQGLNSISRSSKSV 3 15.1 0.99728 -0.10538 0 7.2363 8.10722 0 0 8.65632 0 0 11.4439 0 0 0 0 0 0 A0A8P0TPR9 A0A8P0TPR9_CANLF CDK5 regulatory subunit associated protein 3 CDK5RAP3 Canis lupus familiaris (Dog) (Canis familiaris) AGIDWGISLESDSKEAGGDGIDWG;QEIVALYEKDNTYLVE;QKQQEALQEQAAL 3 11.6 0.85689 0.16821 7.82445 0 0 8.93089 0 0 0 0 8.48555 0 0 4.94902 0 9.76217 0 A0A8P0TPS6 A0A8P0TPS6_CANLF TSPY like 2 TSPYL2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] CDSESPDHNET;DDEDNDGNEGDNEGSDDD;DDNEENTDDNDENPDGDDE;DDYHVMEDI;DNEENTDDNDENPDGDDE;DNEGSDDDGNEGDNEGSDDDDRD;DNTDDNEENTDDNDENPDGD;EDNDGNEGDNEGSDDDGNEGDNE;EGSDDDGNEGDNEGSDDDDRDIED;ESVRKRRRRRRKRKQRKVK;ESVRKRRRRRRKRKQRKVKKERN;GSEEDSEQEGEESDNEEGSDEE;LCDSESPDHNETTDNET;LETCSAEEWEYQG;LSSSEPTQLDQLP;LVEDDDED;NEGSDDDDRDIED;NEGSDDDGNEGDNEG;NPEDNTDDNEENTDDNDENPD;RRKRKQRKVK;RRRRRKRKQRKVKKERNAEKIECIL;RRRRRRKRKQRKVKKERN;TLGAGGPG;VRKRRRRRRKRKQ 24 25.8 0.98138 0.046227 0 0 0 0 0 0 0 0 0 6.25123 0 0 0 0 0 A0A8P0TPT2 A0A8P0TPT2_CANLF LRRCT domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ALHYIKWTDFTNCVT;SLVALYLDNSSI;WLASSAITLNIY;YFLYLNNNFIKR 4 8.1 0.98735 -0.49793 0 0 0 0 12.3049 9.70895 0 0 7.26819 0 0 0 0 0 0 A0A8P0TPT7 A0A8P0TPT7_CANLF Polysaccharide biosynthesis domain containing 1 Canis lupus familiaris (Dog) (Canis familiaris) ELVSVAHAPS;GVGFNMEMTRGTAEPV 2 11.2 1.0027 -0.86221 0 0 0 11.9535 8.70729 0 0 0 0 0 0 0 0 0 0 A0A8P0TPU6 A0A8P0TPU6_CANLF Transient receptor potential cation channel subfamily M member 3 TRPM3 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transmembrane transport [GO:0034220] membrane [GO:0016020] EASPYSFSPSKH 1 3.8 0.95204 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.58669 0 A0A8P0TPV8 A0A8P0TPV8_CANLF Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) NCBP2L Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" nuclear cap binding complex [GO:0005846]; nucleus [GO:0005634] RNA cap binding [GO:0000339] VGGGVALS 1 5.3 1.0038 -1.1044 0 0 0 0 0 0 0 0 0 11.1143 0 0 0 0 0 A0A8P0TPX0 A0A8P0TPX0_CANLF Janus kinase and microtubule interacting protein 3 JAKMIP3 Canis lupus familiaris (Dog) (Canis familiaris) kinase binding [GO:0019900]; microtubule binding [GO:0008017] DKLLRYRKQRKKMAKLPKP;EKELFSKQKGYL;GVSRPRRPTTDGLA;QLTMEYQALQRAYALL 4 6.4 0.79512 0.20992 0 0 0 0 0 0 0 8.38905 4.88996 0 0 0 8.63554 0 9.93276 A0A8P0TPX7 A0A8P0TPX7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] structural constituent of ribosome [GO:0003735] RLLMAILFIYFIVGFTKKK 1 18.8 0.95384 0.04941 0 9.11033 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TPY5 A0A8P0TPY5_CANLF Olfactory receptor LOC119869237 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RVCTILIV 1 2.6 1.0041 -1.1044 0 0 0 0 0 9.79049 0 0 0 0 0 0 0 0 0 A0A8P0TQ16 A0A8P0TQ16_CANLF T-box transcription factor TBX6 TBX6 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of DNA-templated transcription [GO:0045893] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] ARYLFLLDVVPVDGARYRWQ;TLDPHGHV 2 11.5 0.98517 -0.24063 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.05124 A0A8P0TQ23 A0A8P0TQ23_CANLF Active breakpoint cluster region-related protein ABR Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] axon [GO:0030424]; dendritic spine [GO:0043197] GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein serine/threonine kinase activity [GO:0004674] DEGEPDASVADDGGNSSDH;DESPTMSPQLS;DGFLVEVS;DSFGYFVSKAKTRVFRDTTEP;HSAKGFKQSANLY;VLSGFLASEEI 6 6.9 0.95347 0.04941 0 0 0 0 0 0 0 0 7.02569 0 0 0 0 0 0 A0A8P0TQ24 A0A8P0TQ24_CANLF Solute carrier family 16 member 2 SLC16A2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] ADPNGELLPGSP;FPLLIKTLGAKIKLA;SSRQSSHSPPAEMALQS 3 7.6 0.85022 0.15054 8.42568 0 0 0 8.57845 0 0 0 0 0 0 0 0 0 0 A0A8P0TQ25 A0A8P0TQ25_CANLF Acyltransferase (EC 2.3.1.-) MOGAT2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] O-acyltransferase activity [GO:0008374] FDQVENSP;LMSPTSPPK 2 4.4 1.0024 -0.76964 0 0 0 0 0 0 0 0 8.90584 0 0 0 0 0 0 A0A8P0TQ27 A0A8P0TQ27_CANLF Ras-related protein Rap-2a-like LOC480441 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LKDLYIKNSDGFVVLY 1 8 0.96143 0.049233 0 0 0 3.32884 0 0 0 0 9.19471 0 0 0 0 0 0 A0A8P0TQ57 A0A8P0TQ57_CANLF Angiotensin-converting enzyme (EC 3.4.-.-) ACE LOC100856208 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241] CTRVTMDQ;EDLEHLYHQVE;EEAALLNQEFAEV;EQNKRNGEVLGWPEYQ;FQPVSRWLQEQ;IPAHLLGDMWAQSWDNLYDMMVP;LLLLLPLL;PGRPGRGPLPLPLPLLLLLPLLL;RGPLPLPLPLLLLLPLLLPP;RYFLSLVLQFQ;VLQFQFHQALCKE 11 9.4 1.0024 -1.356 0 0 0 0 6.7343 0 7.48519 0 3.86888 0 0 10.7764 11.2404 7.55612 7.29002 A0A8P0TQ61 A0A8P0TQ61_CANLF Chymosin CYM Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] DSVTVNGVVVACDGGCQA;NMMQNHLVAQDLFSVYLSRN;TVPLCPHG 3 11.1 1.0026 -1.0048 0 5.21653 0 0 0 0 0 9.06639 8.9287 0 0 0 0 0 14.3379 A0A8P0TQ65 A0A8P0TQ65_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GTSIRVTADLSTEIWQ;SETVLSPTELQNLD 2 11.2 0.98495 -0.25916 0 0 0 8.79487 9.73528 0 0 0 0 0 0 0 0 0 0 A0A8P0TQ66 A0A8P0TQ66_CANLF COP9 signalosome complex subunit 4 THAP9 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634]; synaptic vesicle [GO:0008021] DNA binding [GO:0003677] AAQRYNELSYKT;ELSYKTIVHESERLE;GKARQKILKQPLP;IDQIDGIVHFETR;QFPTDTIQ;RKILKLPHSSILRTYR;SKKRLVSVKNYRMIKKRKGLRLIDA 7 15.4 1.0027 -0.84868 0 9.72916 6.75449 0 0 0 0 0 0 6.5345 0 0 0 8.39352 0 A0A8P0TQ76 A0A8P0TQ76_CANLF Core shell protein Gag P30 domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) virion assembly [GO:0019068] PSSISETPGPGPA;TVAWPQYRLNNQSQWPPEGTFDYQI 2 7.7 0.94009 0.059801 0 0 0 0 0 0 0 0 0 0 6.36268 0 0 0 6.45039 A0A8P0TQ77 A0A8P0TQ77_CANLF Spondin-like TSP1 domain-containing protein THSD7B Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HDIFKGWSLQ;KCQDSDLYPLIE;LAVICWLWR;LAVICWLWRSM;SCNDHSCMQ;SQALQEYRSCNDHSCMQLYWE;VLSEWTEWS;WTPCPRSCQPG;YGVSGGGF 9 5.3 1.0028 -2.5263 11.9244 11.4236 0 0 0 11.0076 9.66391 0 12.015 4.8622 4.79878 0 0 11.0477 12.1573 A0A8P0TQ94 A0A8P0TQ94_CANLF Protein S PROS1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] calcium ion binding [GO:0005509] FAGLPRKVENVLI;GDRCEYDINECKDPSN;IEAVNLCSN;IMPDICGA;KDTISSEDLPQQFASLD;SFRAGLFTAA;VDECSENLCAQLCVNY 7 14.4 1.0029 -1.6665 0 9.0348 0 0 0 0 0 8.65478 10.5324 0 0 0 0 9.64999 0 A0A8P0TQ97 A0A8P0TQ97_CANLF Adhesion G protein-coupled receptor B3 ADGRB3 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] HCILRREVQ;LLYAFVGPAAAV;QWSTCSVT;RAGQMSEPHSGLTL;RQCTAAAHGGSECRGP;SECRGPWAESRECYNPECTANG;TTQVCNLTREAK 7 5.8 1.0034 -1.5435 9.06334 0 3.52093 0 0 0 0 0 0 4.54603 3.88977 0 13.2573 0 0 A0A8P0TQA1 A0A8P0TQA1_CANLF Trafficking protein particle complex subunit 13 TRAPPC13 Canis lupus familiaris (Dog) (Canis familiaris) regulation of double-strand break repair via homologous recombination [GO:0010569] IIRHNELPSCNATFQRHLDQI;LDQIWVFC 2 10 1.0039 -1.0545 0 10.7381 0 8.9555 0 0 0 0 0 0 0 0 0 9.67592 0 A0A8P0TQB1 A0A8P0TQB1_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) virion assembly [GO:0019068] membrane [GO:0016020] ADSKPGPH;EVCPGRGQTAD;GAPPLPDK;KLDGHSDQVPYILIWQDM 4 12.3 1.0015 -0.99756 10.2524 0 0 0 0 0 0 0 0 0 0 0 0 0 8.41751 A0A8P0TQC7 A0A8P0TQC7_CANLF Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188] G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] ERKKWIHCFEDVTAIIFCVALSGY;EYGDKERK;HESLMLFDSI 3 12 0.98642 -0.2597 0 10.3097 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TQD2 A0A8P0TQD2_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) LMQQFGSVAGYKIN 1 1.9 0.98901 -0.26134 0 0 0 0 0 0 0 0 0 0 0 0 0 10.6805 0 A0A8P0TQD4 A0A8P0TQD4_CANLF "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase)" WARS1 Canis lupus familiaris (Dog) (Canis familiaris) tryptophanyl-tRNA aminoacylation [GO:0006436] ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830] ISFPAIQAAPSFSNSFPQ 1 3.8 0.99613 -0.11372 0 0 0 0 0 0 0 0 10.6781 0 0 0 0 0 0 A0A8P0TQD6 A0A8P0TQD6_CANLF Cation-transporting ATPase (EC 7.2.2.-) ATP13A5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; metal ion binding [GO:0046872]; P-type transmembrane transporter activity [GO:0140358] DFKEVHSFASGKDLPWS;EEQEVRRLVCGP;IDGSCVVNEGMLT;KRLKKKKIF;LVEEFQKLN;PIWKLLVKQVLNPFYV;QKRLKKKKI;QVIFQHFNSL;SEEQEVRRLVCGPNAIEV;SLPCDAILIDG;VLSSTHAYPKLAPY 11 10.1 1.0024 -1.7697 13.6715 9.41424 0 0 0 0 12.4691 0 0 0 0 9.35711 7.53426 0 10.8831 A0A8P0TQE3 A0A8P0TQE3_CANLF Calcineurin binding protein 1 CABIN1 Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] DQGKKYLRDADRQ;EAQEAEAFALYH;EAQEAEAFALYHKALDLQKHDRF;EPDLKLVQ;ESSLESETDEEDDYM;EVMAETPMLPSSL;FASSQRDL;IVLLLKVLAQL;LPSSLMLLNTAHEYLG;LVQQVYFRLHA;PADALQRPSD;PDLKLVQP;RLHASILKLL;SIVLLLKVLAQLR;TVEDDHEGSFKSH 15 6.9 0.97991 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 8.5074 0 A0A8P0TQE5 A0A8P0TQE5_CANLF PDS5 cohesin associated factor A PDS5A Canis lupus familiaris (Dog) (Canis familiaris) mitotic sister chromatid cohesion [GO:0007064] nucleus [GO:0005634] EEEGVSPDT;LDLMSSIIMEGDGV;LLMNDRSTGEK 3 2.9 0.98845 -0.2626 0 0 0 0 0 15.0724 17.0133 0 0 0 0 0 15.569 0 0 A0A8P0TQG4 A0A8P0TQG4_CANLF Transmembrane protein 204 TMEM204 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AMLIWNILHRRED;LVIGLVTFYRIGP;VGKGLTSRQVRSCSLA 3 11.1 0.98738 -0.32451 0 0 0 11.0267 3.91523 0 0 0 11.0688 0 0 0 0 0 0 A0A8P0TQH1 A0A8P0TQH1_CANLF H/ACA ribonucleoprotein complex subunit 2 NHP2 Canis lupus familiaris (Dog) (Canis familiaris) "mRNA splicing, via spliceosome [GO:0000398]" box H/ACA snoRNP complex [GO:0031429] RNA binding [GO:0003723] RRLTRKLYKCIKKAVKQKQI 1 22.2 0.97449 0.048206 0 0 0 0 0 0 0 0 7.10936 0 0 0 0 0 0 A0A8P0TQH3 A0A8P0TQH3_CANLF Phospholipid-transporting ATPase (EC 7.6.2.1) ATP8A2 Canis lupus familiaris (Dog) (Canis familiaris) phospholipid transport [GO:0015914] membrane [GO:0016020] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; magnesium ion binding [GO:0000287] FIALLQQI;FRDNQISIFLYTSSTAKYS;IDGHTLKYALSFE;LKDRAQRLEECYEII;TYVVVTVC 5 5.5 0.98508 -0.2413 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.60763 A0A8P0TQH4 A0A8P0TQH4_CANLF Tetratricopeptide repeat domain 23 TTC23 Canis lupus familiaris (Dog) (Canis familiaris) AHKKLKKVK;ESKETHISNHLDEIVA;FLQAHLIVLSK;GAHKKLKKVKLEPIL;GAHKKLKKVKLEPILI 5 10.6 1.0023 -1.1749 0 0 5.49793 9.71884 6.72206 0 0 0 0 0 0 6.0276 0 0 0 A0A8P0TQH6 A0A8P0TQH6_CANLF Multivesicular body subunit 12A (ESCRT-I complex subunit MVB12A) (Protein FAM125A) MVB12A Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031] ESCRT I complex [GO:0000813]; late endosome membrane [GO:0031902] SH3 domain binding [GO:0017124] EQELGYHWRKLLGVRKEPR 1 5.5 0.95481 0.04941 0 0 6.10547 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TQH8 A0A8P0TQH8_CANLF BHLH domain-containing protein BHLHE23 Canis lupus familiaris (Dog) (Canis familiaris) protein dimerization activity [GO:0046983] DAFERRRRRRR;LDEMRRLVA 2 9 0.98804 -0.49619 9.22497 0 0 0 0 0 0 13.1222 0 0 0 0 0 0 0 A0A8P0TQI7 A0A8P0TQI7_CANLF Microtubule-associated protein MAP4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; microtubule [GO:0005874] microtubule binding [GO:0008017] AEKYPELPAREE;PEPNAVTKTAGPIASAQKP;PPAGKVQI 3 4 0.95338 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 10.2025 0 0 A0A8P0TQL1 A0A8P0TQL1_CANLF Zw10 kinetochore protein ZW10 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634] DLGTRISRLTRRVEEI;DTSNLESFL 2 3.4 0.64557 0.33548 0 0 9.50924 0 9.66798 9.63152 10.341 10.2947 0 9.71055 0 0 0 9.91873 10.2164 A0A8P0TQL5 A0A8P0TQL5_CANLF L-serine ammonia-lyase (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) SDS Canis lupus familiaris (Dog) (Canis familiaris) amino acid metabolic process [GO:0006520] pyridoxal phosphate binding [GO:0030170] ATIVVPSTTPALTIERLKNEG;GGGGLLCG;GVVQGLQEVGWGDVPV 3 13.5 0.99247 -0.16897 0 0 0 0 9.63174 0 0 0 6.86146 0 0 0 0 2.73381 0 A0A8P0TQL7 A0A8P0TQL7_CANLF Zinc finger protein 177 LOC484969 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] DLGHPSTL;EQEALGPEEGGIV;HKTMCTMEESSECNEHGKV 3 8.3 1.003 -1.3443 0 7.16952 0 6.26268 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TQM3 A0A8P0TQM3_CANLF Dipeptidyl peptidase 7 DPP7 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type exopeptidase activity [GO:0070008] WVPRLQRGQDP 1 2.1 0.98314 -0.2525 0 0 0 0 0 0 0 0 10.8981 0 0 0 0 0 0 A0A8P0TQM4 A0A8P0TQM4_CANLF Nuclear receptor binding protein 1 NRBP1 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672] CREEQKNLHFFAPE;EEGVKHHLTLLLKL 2 5.2 0.90345 0.12189 0 0 0 0 0 0 0 0 0 7.234 0 0 9.65785 9.50138 0 A0A8P0TQN6 A0A8P0TQN6_CANLF RRM domain-containing protein LOC608729 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] HCEQQGALMDCVV;SGSGNFGG 2 6.5 0.93779 0.059581 0 0 0 0 0 0 0 0 0 0 0 8.60355 0 0 0 A0A8P0TQP7 A0A8P0TQP7_CANLF "Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial)" LOC100683042 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840] HDRLHTLVTENCFPDMED;LVIPPERLERP;SEQLKKKVASQLSIRKI 3 19.7 0.9919 -0.20692 0 0 0 0 8.34145 0 0 0 0 0 0 0 7.58233 0 0 A0A8P0TQP8 A0A8P0TQP8_CANLF AAA+ ATPase domain-containing protein FIGNL2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] CLDGGGGGGGAGAGAGADGV;GGGGGGGA;GGGGGGGG;KPPGAAEE;LDEATRRRFALRFYV;SQWPEQHLDVSST 6 10.1 0.99311 -0.045497 0 5.79364 0 0 11.467 7.18488 0 7.64249 0 6.14196 0 5.89898 5.51923 0 0 A0A8P0TQP9 A0A8P0TQP9_CANLF Tumor necrosis factor receptor type 1-associated DEATH domain protein TRADD Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634] molecular adaptor activity [GO:0060090] AEDLLGLTNPDGSL;EQAFQLLKRF;PPPGQTFLFQGQP 3 14.7 1.0032 -0.83741 0 0 0 0 0 12.1053 0 0 10.0585 0 0 0 0 0 0 A0A8P0TQQ4 A0A8P0TQQ4_CANLF Homeobox protein engrailed-like EN1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGGAGASK;GGGAGGGR;SPPAAGGG 3 5.2 0.98936 -0.53184 0 7.69377 0 0 0 0 0 12.056 0 0 0 0 0 0 0 A0A8P0TQS0 A0A8P0TQS0_CANLF Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) USP4 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cytoplasm [GO:0005737] cysteine-type deubiquitinase activity [GO:0004843] AEGGGYRERPDA;GVSRGGSGFSASYNCQ;SFPGSSEGGTSPSSSQQG 3 5.1 0.99267 -0.17939 3.11427 2.62947 0 0 0 0 0 0 0 0 0 0 10.9553 0 9.19118 A0A8P0TQS1 A0A8P0TQS1_CANLF Interleukin-2 receptor subunit alpha IL2RA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] interleukin-2 binding [GO:0019976]; interleukin-2 receptor activity [GO:0004911] AGGSGALPLLTTPRQTGVCCWL;NRKGKVTTK 2 11.1 0.97631 0.047975 0 0 0 0 0 0 0 0 10.0402 0 0 0 0 0 0 A0A8P0TQS2 A0A8P0TQS2_CANLF Mitochondria-eating protein (Spermatogenesis-associated protein 18) SPATA18 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial protein catabolic process [GO:0035694] mitochondrial outer membrane [GO:0005741] DYIICHLDLYDSQSSVNDVIRA;LDQRSIDKRNPDQ;PASRSGPCTSS;VLSAEKSVLQGRS 4 9.6 0.82151 0.20345 0 9.15972 8.14771 0 0 0 0 0 0 8.46834 0 0 0 0 0 A0A8P0TQS7 A0A8P0TQS7_CANLF Crystallin zeta CRYZ Canis lupus familiaris (Dog) (Canis familiaris) oxidoreductase activity [GO:0016491]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] LANVNLSNDLDLLSY;SIIGTALYSSTKVI 2 4.5 0.92144 0.11986 0 0 0 8.60463 0 0 11.3288 0 0 0 0 0 0 0 11.4837 A0A8P0TQS9 A0A8P0TQS9_CANLF SH3 domain containing 19 SH3D19 Canis lupus familiaris (Dog) (Canis familiaris) EDIVSQNPGE;EEWARGELRDKTGIFPL;EITIVAAEPLRPAS;EQNHHKTSPAATEKESSLSQ;GVGRGGGG;LPAKPEIAPRTL;VTKPVLPKKPNAGLIRSV 7 7.5 0.99692 -0.58966 0 0 0 0 0 0 0 0 9.55637 0 0 8.80549 11.3102 0 8.14297 A0A8P0TQT3 A0A8P0TQT3_CANLF Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) PAFAH1B1 LIS1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lipid catabolic process [GO:0016042]; microtubule sliding [GO:0051012]; nervous system development [GO:0007399] centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nuclear membrane [GO:0031965]; spindle [GO:0005819] dynein complex binding [GO:0070840] YEEAYSVFKKEAELDMNEELDKKY 1 6.4 0.97393 0.041303 0 0 0 0 0 0 0 8.49717 0 0 0 0 0 0 0 A0A8P0TQU1 A0A8P0TQU1_CANLF Stabilizer of axonemal microtubules 2 SAXO2 Canis lupus familiaris (Dog) (Canis familiaris) microtubule binding [GO:0008017] LDYVPYQLE;SFQPWEIPP;VLRMRDDYRAWDIQ 3 7.8 0.98448 -0.25497 0 0 0 0 0 0 0 0 9.57675 0 0 0 0 0 0 A0A8P0TQU7 A0A8P0TQU7_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) sulfotransferase activity [GO:0008146] EPHFFDRNYEKGLEWYRNVKLNTQS;VTYLCYSL 2 10.9 0.99062 -0.29766 0 0 0 0 0 0 0 0 9.75139 0 0 0 0 0 0 A0A8P0TQV1 A0A8P0TQV1_CANLF Ferritin Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199] ASTAPILA;GVAINYIASYE 2 9.8 1.0025 -1.3867 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.60363 A0A8P0TQV5 A0A8P0TQV5_CANLF 60S ribosomal protein L7 Canis lupus familiaris (Dog) (Canis familiaris) EKVKHYHKEYRQMYRTEIRMARMA;GVSPKVRKVLQLLRLHQIFF 2 18.5 0.9373 0.089509 0 0 0 0 0 0 0 0 8.39502 0 0 0 0 6.07142 0 A0A8P0TQW5 A0A8P0TQW5_CANLF Calcium/calmodulin-dependent protein kinase type II subunit delta CAMK2D Canis lupus familiaris (Dog) (Canis familiaris) sarcolemma [GO:0042383]; sarcoplasmic reticulum membrane [GO:0033017] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] ETRWSKGAPN 1 3 0.99884 -0.61146 0 0 0 0 0 0 0 8.5371 0 0 0 0 0 0 0 A0A8P0TQX5 A0A8P0TQX5_CANLF Solute carrier family 34 member 3 SLC34A3 Canis lupus familiaris (Dog) (Canis familiaris) sodium-dependent phosphate transport [GO:0044341] plasma membrane [GO:0005886] sodium:phosphate symporter activity [GO:0005436] LAAPPPQVLGL;LVLIVKLLNSVLRGRVAQ;NVVLSNPVAGLVIGVLVTV;TAAIVPLMGCPHP;VEQLPCHHL 5 12.8 1.0032 -0.88816 9.63771 8.40114 0 0 9.57994 0 11.0843 5.93965 0 0 0 0 9.38675 0 0 A0A8P0TQY2 A0A8P0TQY2_CANLF phosphoinositide 5-phosphatase (EC 3.1.3.36) INPP5B Canis lupus familiaris (Dog) (Canis familiaris) phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] early endosome membrane [GO:0031901]; phagocytic vesicle membrane [GO:0030670] inositol phosphate phosphatase activity [GO:0052745] KVKLIRLVGIMLLLYVK;PSLPPLTISKHDV;YLYQNAVQQVISTLPTFHQNVFNYL 3 6.5 0.9918 -0.29561 0 0 0 0 0 0 0 10.6394 0 0 0 0 0 0 0 A0A8P0TQZ3 A0A8P0TQZ3_CANLF Bcl-2-interacting killer BIK Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915] membrane [GO:0016020] LVLSLLLLLVLLLGWGLRLL;VLSLLLLLVLLLGWGLRL 2 8.6 0.93233 0.096519 0 0 0 0 0 3.78764 0 0 0 0 0 0 6.43778 0 0 A0A8P0TQZ5 A0A8P0TQZ5_CANLF SH3 domain-binding protein 5 (SH3BP-5) SH3BP5L Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] cytoplasm [GO:0005737] guanyl-nucleotide exchange factor activity [GO:0005085]; SH3 domain binding [GO:0017124] ASEEINQVELQ;EGAEGGGLEEGSSL;GVMADKNRLDPTWQ;PDTDTLSL 4 12 1.0033 -1.5695 0 0 0 0 0 10.5829 0 8.98965 0 0 0 12.6389 0 0 0 A0A8P0TQZ8 A0A8P0TQZ8_CANLF HscB mitochondrial iron-sulfur cluster cochaperone HSCB Canis lupus familiaris (Dog) (Canis familiaris) [2Fe-2S] cluster assembly [GO:0044571]; protein complex oligomerization [GO:0051259] ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087] FLMEIMEINEKLAEAQ 1 7.3 0.99564 -0.086615 0 0 0 0 0 0 0 10.8143 0 0 0 0 0 0 0 A0A8P0TR02 A0A8P0TR02_CANLF DPY30 domain containing 1 DYDC1 Canis lupus familiaris (Dog) (Canis familiaris) Set1C/COMPASS complex [GO:0048188] EDSSHAED 1 4.6 0.99194 -0.1797 0 9.30417 0 0 0 0 0 0 9.67509 0 0 9.83439 0 0 0 A0A8P0TR18 A0A8P0TR18_CANLF Chromosome 23 C3orf33 homolog C23H3orf33 Canis lupus familiaris (Dog) (Canis familiaris) APRPEHQHRNGRSWNNVTS;HKKLLKAELTALR;RELMNRIHFRR 3 15.6 0.86145 0.1449 0 0 8.2226 0 0 0 0 0 0 0 0 0 8.62888 0 0 A0A8P0TR20 A0A8P0TR20_CANLF Small glutamine rich tetratricopeptide repeat co-chaperone beta SGTB Canis lupus familiaris (Dog) (Canis familiaris) EDTHLAVS 1 2.8 0.98349 -0.25362 0 0 0 0 9.54757 0 0 0 0 0 0 0 0 0 0 A0A8P0TR27 A0A8P0TR27_CANLF Alpha-2-macroglobulin LOC477699 Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] EREESPFALEVQTLPQTCDRPK;KPQYMVLVPSLL;KPQYMVLVPSLLH;LAKPEAEL;LAKPEAELSAASVYNLL;LFASPVVSELQ;LQRSHELTD;RLFASPVVSELQ;SLSFMVLQDVP;SVSGKPQYM;SVSGKPQYMVLVPSLL;TDEFAIAEYN;VDDDNRLLLQQT;VHFSEPLTE;YSGTFFTK 15 8.5 0.43125 0.5091 12.271 12.7311 12.6257 9.97226 10.4847 9.55915 13.0681 13.1744 13.3093 0 11.0738 9.36094 12.589 12.5317 12.7813 A0A8P0TR28 A0A8P0TR28_CANLF E3 ubiquitin-protein ligase (EC 2.3.2.27) DTX4 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] cytoplasm [GO:0005737] ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270] VGKLSRCGHIYHI;VPSQAIRRQASSTPAGG 2 5.9 0.91383 0.11059 8.85493 0 0 0 0 5.54489 0 0 0 0 0 0 0 0 0 A0A8P0TR32 A0A8P0TR32_CANLF Unc-13 homolog B UNC13B Canis lupus familiaris (Dog) (Canis familiaris) chemical synaptic transmission [GO:0007268] synapse [GO:0045202] diacylglycerol binding [GO:0019992] DQCHEQDDDRRERDSIHSCHSS;QEKALEVTGE;VICHWSSPGKQ 3 9.4 0.98859 -0.22734 0 0 0 0 0 0 0 11.0137 0 0 0 0 0 0 0 A0A8P0TR58 A0A8P0TR58_CANLF MAX dimerization protein 4 MXD4 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] protein dimerization activity [GO:0046983] RAKLRLYLEQL 1 5.5 0.98183 0.035491 0 0 0 0 0 0 0 6.2465 0 0 0 0 0 0 0 A0A8P0TR59 A0A8P0TR59_CANLF B-TFIID TATA-box binding protein associated factor 1 BTAF1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; TBP-class protein binding [GO:0017025] DEDLDYTPTSAAF;IDVLLLTTHVG;IMGLQKFKMNI;NEVTSSFDLNPQVL;NMSEELIQ;PKERIARQRKLLQKKLGLNMGEAI;VISQENSSLQSMGT 7 5.3 0.98923 -0.519 0 0 8.45693 8.43546 9.00848 0 9.06579 0 6.34175 0 0 0 7.19022 0 0 A0A8P0TR60 A0A8P0TR60_CANLF Zinc knuckle domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) GSRKEQRQRQEEQE 1 4.5 0.93572 0.060938 0 0 0 0 0 0 0 6.42514 0 0 0 0 0 0 0 A0A8P0TR80 A0A8P0TR80_CANLF Methyl-CpG binding domain protein 2 MBD2 Canis lupus familiaris (Dog) (Canis familiaris) nucleoplasm [GO:0005654] DNA binding [GO:0003677] GDGGGGGG;GGDGGGGG;GGGGGGGA;GGGGGGGG;WHVLSRFCLLMCCFL 5 10.6 0.95145 0.053889 0 0 0 0 0 0 0 9.4143 0 0 0 0 0 0 0 A0A8P0TR81 A0A8P0TR81_CANLF LDL receptor related protein 1B LRP1B Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897] membrane [GO:0016020] calcium ion binding [GO:0005509] AWICDGDIDCEDQSDEDDCDSFL;CDGDNDCGDF;CDGEDDCG;CDHDDDCGDGSDE;CDHDDDCGDGSDESLQCG;CDSDDDCGDG;CDTVDDCGDGSDE;CNGEYDCADGSDEMDC;CNGQDDCGDE;DCSDNSDEENCKPQ;DEEDERDCP;DGEDDCGDN;DGEDDCGDNSDEAPDMC;DIPHQPMGIIAVAND;DPDCADASDEANCDKKTCGP;DQNFQERNNT;EDQSDEDDC;EDQSDEDDCD;EDYIYGAGPKN;EIHTLDFIYNE;EQMCNGIDDCGDNSDEDHCG;FSGPEEVEIKCPLNHIAC;GDHQQISHIEH;GDIDCEDQSDEDDCDSF;GDQTDEMASCEFPTCEPLTQFIC;GNEFQCHPDGNCI;GSDEMDCVTEC;GWMYWTDWEEDEIDDSV;HCDSDDDC;HCDSDDDCGDGSDEVGCVH;IDCEDQSDEDDCD;INKDSEDIFCNC;KHWICDGEDDCGDGLDESD;LCPPTRPHRCR;NCEASCSKDQFQCSNGQCI;NGQDDCGDEEDERD;NILQSFHNVQQ;NRHCIQARWKC;QFRCRNKAHCIPIRWLCDGIHD;QFRCSSGRCIPGHWACDGDN;RVQKFGHGSVEYLALDID;RWKCDGDDDCLDGSDEDSVN;RWLCDGANDCGSNEDESNQTC;SDETNLNSPIRPYENPHYFKN;SSCNMYSEFECGNGECIDYQL;SWICDGSNDCGDYSD;SYACSCVE;TVDDCGDGSDEPDDCPE;VDHFSERIYWADLELSVIG;VEYLALDIDKTKGVL;VLCKRKRRTKTIRRQ;VYAKLYMDGQ;WACDGDNDCGDFSD;WCDGDFDCAD;WQCDGDFDC;WQCDGDFDCS;YKDMKTGAWPNG 57 14.3 0.99669 -11.042 8.59369 9.7205 10.5831 8.55025 9.93133 10.7554 10.2508 12.9904 10.2517 7.47111 5.54615 0 9.87064 11.3983 10.6186 A0A8P0TR86 A0A8P0TR86_CANLF protein-tyrosine-phosphatase (EC 3.1.3.48) PTPRQ Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] protein tyrosine phosphatase activity [GO:0004725] EITCMNCT;GGLVKIYSLKIHEHET;ISYDLTLQGPN;LASGTDFL;LISIITTKGLKRSHPTVLMV;LMEDVQIDWTIRDL;VSWPSARS 7 2.8 1.0031 -2.2995 0 9.46027 0 0 0 0 0 8.21529 9.83592 0 0 0 12.2137 8.86177 0 A0A8P0TR96 A0A8P0TR96_CANLF Protein BTG1 (B-cell translocation gene 1 protein) BTG1 Canis lupus familiaris (Dog) (Canis familiaris) SPAGGSTQ;VLYEASPAGGST 2 7.6 0.99638 -0.57566 12.923 0 0 0 0 0 0 12.9716 13.1193 0 0 0 0 0 0 A0A8P0TRA3 A0A8P0TRA3_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) HRCISSTDLAWMVQDNHLSFMVH 1 17.8 0.97667 0.046431 0 0 0 0 0 0 0 0 0 0 0 6.51814 0 0 0 A0A8P0TRA4 A0A8P0TRA4_CANLF Polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase) GALNT1 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] carbohydrate binding [GO:0030246]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653] KTVVCPIIDVISDDTFE;LEEIVLVDDASERDF;SWYLENIYPDSQ;VISDDTFEYMAGSDMTYGG;VITFLDAHCECTVGW;VKKLKVPV 6 14.8 1.0029 -0.75538 0 0 8.69063 3.89424 0 0 0 0 0 0 0 0 0 0 8.6466 A0A8P0TRA7 A0A8P0TRA7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) secretory granule [GO:0030141] CRPILCGG;DTGRNLSLPGRRT;PGLLGCLFQDDLCSS 3 21.6 1.0022 -1.0139 5.11366 8.48872 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRB4 A0A8P0TRB4_CANLF Solute carrier family 12 member 8 SLC12A8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] chloride:monoatomic cation symporter activity [GO:0015377] CSLRQVPESV;GVKWIIRLQLLLLFLL;IAEKVSLVGFLFLLGL;IAVDYSYFSLSM 4 8.3 0.94286 0.10051 0 9.25316 4.31477 0 0 0 0 0 0 0 4.53113 0 6.64472 0 0 A0A8P0TRD7 A0A8P0TRD7_CANLF Proline rich membrane anchor 1 PRIMA1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGEGSSGTPA 1 2.6 0.9917 -0.18188 0 0 0 0 0 0 0 0 0 7.28466 7.57175 0 0 0 0 A0A8P0TRD9 A0A8P0TRD9_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] HNKKFGRTSNTWSLRTILLK;MNEKGEITTNT;PSICCLQETHFRQ 3 3.5 0.95382 0.049325 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.25248 A0A8P0TRF7 A0A8P0TRF7_CANLF AP complex subunit sigma LOC100684998 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] membrane [GO:0016020] LDEMMLNGCIVET;MAIYEFIHNFVEVL;VSELDIMFN 3 35.6 0.99249 -0.19294 0 0 5.3482 0 0 0 8.6995 0 0 0 0 0 0 0 0 A0A8P0TRG5 A0A8P0TRG5_CANLF SFI1 centrin binding protein SFI1 Canis lupus familiaris (Dog) (Canis familiaris) AARESQHKRRLLRSVFRRWR;AELESIQQQLQ;AFNTWRRFWRWHQ;DSHFQQRALPAAF;HCRMTLLRKCIK;KLHMQTTALEFRQQ;KRLLQRQGAQ;LQDYQTMKQNLSS;LWFWSFSLQ;MKAFRQQLHAQQQEQAA;QEELQEVELQIQQ;RIEQREEREQLPSL;SERQLLQRSWSM;SSFMPCGVE;VELQIQQL;VLERRRKK 16 14.9 1.0029 -2.489 9.14911 11.4924 9.24267 4.70027 0 9.2555 9.91955 11.6325 10.9198 5.98593 0 7.7894 0 0 5.86607 A0A8P0TRH4 A0A8P0TRH4_CANLF Fibrinogen C-terminal domain-containing protein LOC607055 Canis lupus familiaris (Dog) (Canis familiaris) VQVALLEPQGRDCSHIWAGSPGAP 1 7.3 0.9922 -0.291 0 0 0 0 0 0 0 0 8.92327 0 0 0 0 0 0 A0A8P0TRH7 A0A8P0TRH7_CANLF RING-type domain-containing protein RNF183 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] metal ion binding [GO:0046872] LLIFSIFWTKQFL;VCWNPFNNTFHTP 2 13.7 0.92179 0.11944 0 0 0 0 8.21553 0 0 0 0 0 0 0 7.13402 0 0 A0A8P0TRH8 A0A8P0TRH8_CANLF Crumbs cell polarity complex component 1 CRB1 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] CHNNATCED;ELNIDECFSNPCIH;EPCHNNATCEDSADNYTCHCWPGYT;GVCYSLWDDFSCSCPAN;ITLEDISSSSSLNVK;KAGCERKDWCERQ;NNATCEDSADNYTCHCWPGYTGAQC;RDANVIILH;SGLLLALEN;VDECQSQPCRNGATC 10 9.3 0.99383 -0.11944 0 10.4819 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRI8 A0A8P0TRI8_CANLF Homeobox D8 HOXD8 Canis lupus familiaris (Dog) (Canis familiaris) DNA-templated transcription [GO:0006351] nucleus [GO:0005634] DNA binding [GO:0003677] AAAAAAAATSTSSSTSTSSSSKRTE;AQELEEDRAEGLT;EFLFNPYLTRKRRIEVSHALALTE;GAGGGGGG;GGGGGGGG;GGGGGGPG;GGGGGGSG;VGGSGAGG 8 22.6 0.99436 -0.12339 0 0 0 0 0 8.35892 0 0 0 0 0 10.3776 0 8.88993 0 A0A8P0TRJ2 A0A8P0TRJ2_CANLF Zinc finger protein 683 ZNF683 Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] LPFCLHPISPAY;SLDSQLCQGDQ 2 4.8 0.98986 -0.52817 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.86839 A0A8P0TRJ6 A0A8P0TRJ6_CANLF SH2B adaptor protein 3 SH2B3 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] signaling adaptor activity [GO:0035591] EELANSLQHLEP;TDPEMHIPSALEP 2 7 0.91535 0.11015 0 5.68114 0 8.44828 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRK8 A0A8P0TRK8_CANLF Tubulin tyrosine ligase like 2 TTLL2 Canis lupus familiaris (Dog) (Canis familiaris) protein modification process [GO:0036211] LNVRRIIQKL;LNVRRIIQKLQK;LNVRRIIQKLQKLKN 3 2.9 0.989 -0.50714 0 0 0 0 6.64058 0 0 0 0 0 0 0 3.87873 5.03505 0 A0A8P0TRL1 A0A8P0TRL1_CANLF Potassium channel domain-containing protein KCNK16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] potassium channel activity [GO:0005267] NSTNPSNWDFGS 1 4.1 0.95378 0.05044 0 0 0 0 0 0 0 0 0 7.99639 0 0 0 0 0 A0A8P0TRM2 A0A8P0TRM2_CANLF PR/SET domain 2 PRDM2 Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] nucleus [GO:0005634] histone methyltransferase activity [GO:0042054] DLQLKTGEPDSASANMRDSAEG;EPDEKPEATNCE;EVNDLEEEEEEEEDEDDELE;EVNDLEEEEEEEEDEDDELEE;GDSRREDSGGKQ;GVRRKGGLLEEPHPPAE;QTAVLQEAASQDVLP;TDPSKAHREHMQSLPE 8 7.2 0.938 0.099957 0 5.47246 0 0 0 0 7.56788 0 7.77525 2.02031 0 4.86804 6.55882 6.59479 8.71346 A0A8P0TRM8 A0A8P0TRM8_CANLF Progestin and adipoQ receptor family member 7 PAQR7 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] metal ion binding [GO:0046872] FLDYVGVAVYQFGSALAHFY;SEFWHYSFFFLDYV 2 5.6 0.91691 0.10946 0 0 0 0 0 5.57286 0 0 0 0 0 8.01903 0 0 0 A0A8P0TRN4 A0A8P0TRN4_CANLF Cilia and flagella associated protein 57 CFAP57 Canis lupus familiaris (Dog) (Canis familiaris) ALKLTKKIR;EAKLQEKTTLLEEAQEDV;FYRESREIRIPLD;VILASGHSQL 4 4.4 1.0029 -0.84865 7.04549 0 9.68335 0 0 0 0 0 0 0 0 10.9821 0 0 0 A0A8P0TRN6 A0A8P0TRN6_CANLF SRY-box transcription factor 13 SOX13 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] EAKDVKGTQESLAEK;KQQQQLIQQQHKINL;LDPNMPVIVNTCSLR;LSRQHLEKYPDYKYK;LYRYSEDEDSEGEEKSDGE;PGAMAAHPPLQPLNLTAKPKA;PQLGDPARAPQ;PRSLDPNMPVIV;RQHLEKYPDYKYKPR;SDWKERFLGRSSVEAK 10 20.3 0.98432 -0.25438 4.74556 10.0342 0 0 8.73623 0 11.1325 10.5123 0 0 0 5.73102 10.551 5.65329 0 A0A8P0TRN7 A0A8P0TRN7_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial outer membrane [GO:0005741] ANSSYTVTRNYAV;YLISRGLVGGFL 2 23.4 0.98779 -0.36732 0 0 0 0 0 0 9.89362 0 0 0 0 0 0 0 0 A0A8P0TRP0 A0A8P0TRP0_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) BMPR2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; transmembrane receptor protein serine/threonine kinase activity [GO:0004675] AAASQNQERL;AAASQNQERLCAFKDPY;ANRQNFINEKNIYRV;DINLVKQGCWSHI;DINLVKQGCWSHIG;PSTGMTTISEMP;QAGHDEGVLDRL;QECHYEECV;VPPAQIYPLPKQQNL;YPDYSSSSYIED 10 10.6 1.0036 -1.6483 0 0 9.14412 0 10.0961 9.76843 10.2909 0 7.85443 0 0 8.74221 0 0 0 A0A8P0TRQ0 A0A8P0TRQ0_CANLF "Cofilin-1 (Cofilin, non-muscle isoform)" Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] actin cytoskeleton [GO:0015629]; lamellipodium membrane [GO:0031258]; nucleus [GO:0005634]; ruffle membrane [GO:0032587] actin filament binding [GO:0051015] GGGGGGGA;GVAGCPLP;LDLPPPSIPDGSG;PGGGGGGG 4 18.9 1.0039 -1.0403 0 0 0 0 0 0 0 0 7.43979 0 0 0 10.7829 0 0 A0A8P0TRQ8 A0A8P0TRQ8_CANLF Vacuolar protein sorting-associated protein 11 homolog VPS11 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765] metal ion binding [GO:0046872] CGHSFHQHCFESYSESDAD;HSFHQHCFESYS;SQDLQFIVAGDECVYLYQP 3 4.4 0.9938 -0.13254 0 0 0 0 0 3.63204 0 0 0 0 0 0 0 8.92985 9.36028 A0A8P0TRR3 A0A8P0TRR3_CANLF DNA topoisomerase 2 (EC 5.6.2.2) TOP2A Canis lupus familiaris (Dog) (Canis familiaris) DNA topological change [GO:0006265]; rhythmic process [GO:0048511] nucleolus [GO:0005730]; nucleoplasm [GO:0005654] "ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]" DLWKEDLAT;GLPGKGGK;PKGTKKDPGLNSDVSQKPDPP;PVKGFRSYVDMYLKDKVDE;VGSNNLNLLQ 5 4.7 1.0032 -2.0777 0 8.88499 9.42916 8.87058 9.30581 0 0 0 0 0 8.62994 0 0 0 0 A0A8P0TRT2 A0A8P0TRT2_CANLF Membrane spanning 4-domains A6A LOC612553 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VNLAALDPAFWNCDLDSKKE 1 8.2 0.94863 0.05015 0 0 0 0 0 0 0 0 0 0 8.23707 0 0 0 0 A0A8P0TRU9 A0A8P0TRU9_CANLF V-set and immunoglobulin domain containing 10 VSIG10 Canis lupus familiaris (Dog) (Canis familiaris) intracellular signal transduction [GO:0035556] LDPRSWSHCV;QGHCIVKLIPW 2 4.6 0.99661 -0.57816 0 0 0 0 0 0 0 0 0 0 0 0 10.1106 0 0 A0A8P0TRV1 A0A8P0TRV1_CANLF Ras-related protein Rab-3 TXNDC12 RAB3B Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] plasma membrane [GO:0005886] GTP binding [GO:0005525]; GTPase activity [GO:0003924] LDTDPSTLGT 1 4.4 0.99884 -0.61146 9.52089 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRV3 A0A8P0TRV3_CANLF Family with sequence similarity 216 member A FAM216A Canis lupus familiaris (Dog) (Canis familiaris) ETDNYEYYGSAGHSYYH;STNDSESYMNEE 2 10.3 0.97925 0.046227 0 0 0 0 0 0 5.03474 0 0 0 0 0 0 0 0 A0A8P0TRV5 A0A8P0TRV5_CANLF Uncharacterized protein TMEM229A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GPPDAGVL;YRGRPSRGPSLGRA 2 6.6 0.99265 -0.19359 0 0 9.81909 7.40523 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRX1 A0A8P0TRX1_CANLF AKT1 substrate 1 AKT1S1 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of TOR signaling [GO:0032007]; neurotrophin TRK receptor signaling pathway [GO:0048011] TPAGPPAYSVPP 1 4.7 0.99537 -0.15859 0 0 0 9.00259 0 0 0 0 0 0 9.10449 0 0 0 0 A0A8P0TRX7 A0A8P0TRX7_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) VGKPVTLNCSQ 1 6.7 0.98123 0.035491 0 0 0 0 0 0 8.93567 0 0 0 0 0 0 0 0 A0A8P0TRY1 A0A8P0TRY1_CANLF adenylate cyclase (EC 4.6.1.1) ADCY7 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] LPVSLPTHARN 1 1.1 0.98165 -0.2495 9.62055 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRY6 A0A8P0TRY6_CANLF Mitogen-activated protein kinase (EC 2.7.11.24) Canis lupus familiaris (Dog) (Canis familiaris) caveolin-mediated endocytosis [GO:0072584]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872] caveola [GO:0005901]; cytoskeleton [GO:0005856]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770] ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] YLEQYYDPTDE;YYDPTDEPVAE 2 4.8 0.98654 -0.23155 9.46887 8.97997 0 0 0 0 0 0 0 8.90851 0 0 0 0 0 A0A8P0TRY8 A0A8P0TRY8_CANLF Eukaryotic translation initiation factor 4H EIF4H Canis lupus familiaris (Dog) (Canis familiaris) perinuclear region of cytoplasm [GO:0048471] RNA binding [GO:0003723] SIRSVRLVRDKDTDK 1 6.7 0.95365 0.053902 0 0 0 3.92429 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TRZ2 A0A8P0TRZ2_CANLF Cryptochrome-1 CRY1 Canis lupus familiaris (Dog) (Canis familiaris) rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] nucleotide binding [GO:0000166]; photoreceptor activity [GO:0009881] LEELGFDTDGLPSAVWPGGE;LYDLDKIIELNGGQP 2 6.6 0.98405 -0.24197 0 0 0 0 0 5.90294 0 0 0 0 0 0 0 0 0 A0A8P0TS03 A0A8P0TS03_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) DCVAVAMVPAFTPI 1 15.6 0.98377 -0.24769 0 0 0 0 10.7193 0 0 0 0 0 0 0 0 0 0 A0A8P0TS05 A0A8P0TS05_CANLF Adenine nucleotide translocase lysine methyltransferase ANTKMT Canis lupus familiaris (Dog) (Canis familiaris) methylation [GO:0032259] protein-lysine N-methyltransferase activity [GO:0016279] GRNAREGPGPP;GTTFLGGWGGLTAPRDRG;PAGAGGPQVRPSPGAG 3 8.9 0.99839 -0.60479 0 0 0 0 0 0 11.434 0 0 0 0 0 0 0 0 A0A8P0TS09 A0A8P0TS09_CANLF VGF nerve growth factor inducible VGF Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide hormone activity [GO:0005184] DELFPPGP;EEGGEEEDDDEEMDPQ;EGAEEGGEEEDDDEEMD;EGGEEEDDDEEMDP;GVSSPKTHLGE;MQEQEELE 6 7.5 1.0044 -2.0171 10.0412 2.61925 8.62761 9.31141 0 0 0 8.81599 0 0 4.48052 0 8.22115 8.82814 0 A0A8P0TS18 A0A8P0TS18_CANLF Solute carrier family 12 member 2 SLC12A2 Canis lupus familiaris (Dog) (Canis familiaris) sodium ion transmembrane transport [GO:0035725] apical plasma membrane [GO:0016324] chloride:monoatomic cation symporter activity [GO:0015377]; potassium ion transmembrane transporter activity [GO:0015079] ADKMKEDEPWRITDN;AGANISGDLADPQSAIP;GAVSSALY;KAQIVLLVILLLAIADFVIG;SLHSGGGGGSGGGSGHHQ 5 6.7 0.98752 -0.366 0 0 9.18982 7.99022 4.4719 8.3972 0 0 0 0 7.51964 0 0 4.49179 0 A0A8P0TS31 A0A8P0TS31_CANLF Prostaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) PTGES2 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin biosynthetic process [GO:0001516] membrane [GO:0016020] prostaglandin-E synthase activity [GO:0050220] EDLYEAAD;FCNKYWLMLDEKEA;GAVAKYMGAAAMYFI;GKFGAVEG;GPGGQGPA;TRLAPKKSVSS 6 17.4 1.0033 -2.0951 7.79799 12.4306 0 9.67235 0 0 0 0 12.901 10.6084 0 11.6587 9.35643 10.1883 0 A0A8P0TS46 A0A8P0TS46_CANLF "Protein phosphatase, Mg2+/Mn2+ dependent 1K" PPM1K Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] cation binding [GO:0043169] GAPSQDPG;PGTVTSGAP 2 6.4 1.0038 -1.0618 0 8.49478 0 0 10.1003 10.1344 0 11.7749 0 0 11.7647 11.9018 0 0 0 A0A8P0TS49 A0A8P0TS49_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LDAHPTQCYILP 1 10.7 0.95336 0.05044 0 0 0 0 0 0 0 5.31419 0 0 0 0 0 0 0 A0A8P0TS50 A0A8P0TS50_CANLF Glutathione S-transferase C-terminal domain-containing protein GSTCD Canis lupus familiaris (Dog) (Canis familiaris) IQFLHLPELLTTSN;LDFFHQIEGCIFPLHTSV 2 5.6 0.91547 0.10926 0 9.74942 0 5.24142 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TS52 A0A8P0TS52_CANLF G protein subunit beta 2 GNB2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] AGVLAGHDNRV;GDVMSLSLAPDGRTFVS 2 8.6 0.98224 0.046227 0 0 0 8.23093 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TS56 A0A8P0TS56_CANLF Solute carrier family 38 member 3 SLC38A3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PLALMRQLGYLGYS;VIYKKFHVP 2 4.7 0.98452 -0.24702 0 0 0 7.79175 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TS69 A0A8P0TS69_CANLF Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) HENMT1 Canis lupus familiaris (Dog) (Canis familiaris) regulatory ncRNA-mediated gene silencing [GO:0031047]; RNA methylation [GO:0001510] O-methyltransferase activity [GO:0008171]; RNA methyltransferase activity [GO:0008173] ADLGFGDA;DLMTCIELI;EWNRIQFQTW 3 10.6 1.003 -1.7257 0 0 0 0 0 0 0 0 0 0 8.25243 0 0 0 0 A0A8P0TS70 A0A8P0TS70_CANLF Migration and invasion inhibitory protein MIIP Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] KQCEPDYYLDRDG;LEKSISVV;LGGGAPLTPEDDPKVAR 3 7.9 0.98628 -0.42344 0 0 0 0 0 0 0 10.3696 0 4.72623 0 0 0 9.6647 0 A0A8P0TS71 A0A8P0TS71_CANLF "KH domain-containing, RNA-binding, signal transduction-associated protein 2" KHDRBS2 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; mRNA processing [GO:0006397] nucleus [GO:0005634] RNA binding [GO:0003723]; SH3 domain binding [GO:0017124] EYGYDDGYGGEYDDQTYETYENSYA;EYYDYGHGV;GIRIAPTT;GYDDGYGGEYDDQTYETY;LVPDYNDEIRQEQLRELSYL;PVKQYPKF 6 21.9 1.0031 -1.6586 10.3926 0 0 10.1047 0 9.61204 0 9.99322 0 11.5057 11.4157 0 0 10.4642 0 A0A8P0TS78 A0A8P0TS78_CANLF Jade family PHD finger 2 JADE2 Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ARKPTRRTPSHLP;FTHLRQDLE;LELAEALV;QQEQDVLYR 4 5.2 1.0018 -1.2534 0 0 0 0 0 9.49895 0 0 0 10.2317 0 0 0 0 0 A0A8P0TS79 A0A8P0TS79_CANLF SMC5-SMC6 complex localization factor 2 SLF2 Canis lupus familiaris (Dog) (Canis familiaris) ELSSHPHNL;EQMEQRINSENSFSE;GYNLDSDEEEET;ISVLHRYLVQM;PSNSGHHSSRNSDQI;TDCIVSVQILSTLMEI;VLKWLFRMM 7 8.1 1.0021 -1.8332 0 0 8.52026 4.20821 5.59932 0 8.52638 7.18606 0 0 9.3548 0 0 0 0 A0A8P0TS80 A0A8P0TS80_CANLF G-protein coupled receptors family 1 profile domain-containing protein LOC106560021 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993] AAAGVALA;LVVTLLVLLIAATFLWNLLVLVTI;PGREPPLSVFTVLVVTLLVL 3 12.4 1.0022 -1.0144 9.5514 0 0 0 0 0 6.54996 6.77939 0 0 0 0 12.8161 0 0 A0A8P0TS82 A0A8P0TS82_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) LLPKQKIVNPVKVSTT 1 12.8 0.95824 0.049233 0 0 0 0 0 4.45306 0 0 0 0 0 0 0 0 0 A0A8P0TS86 A0A8P0TS86_CANLF Claudin 10 CLDN10 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction [GO:0005923]; membrane [GO:0016020] structural molecule activity [GO:0005198] FHCRPHFTIFKVEGYFWLLE;IFCFSISDNN 2 11.3 0.98451 -0.24174 0 0 0 0 9.31327 0 0 0 0 0 0 0 0 0 0 A0A8P0TS92 A0A8P0TS92_CANLF L-lactate dehydrogenase (EC 1.1.1.27) LDHAL6B Canis lupus familiaris (Dog) (Canis familiaris) carboxylic acid metabolic process [GO:0019752] cytoplasm [GO:0005737] L-lactate dehydrogenase activity [GO:0004459] TPEEQARLKKS 1 2.9 0.98479 0.035491 0 0 0 0 0 0 0 5.77797 0 0 0 0 0 0 0 A0A8P0TS94 A0A8P0TS94_CANLF Obg-like ATPase 1 OLA1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleolus [GO:0005730] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; ribosomal large subunit binding [GO:0043023] DKLEKVAVR;GAHNGQGL;YIRKKNKWLIKIK 3 7.5 0.99311 -0.55576 0 12.1068 0 0 0 0 0 0 0 0 0 12.1747 4.53282 0 0 A0A8P0TSA2 A0A8P0TSA2_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) CDKL3 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine phosphatase activity [GO:0004722] EVRCPVTVCGDVHGQFHDLMELFR;IKIFYEKPEK;RHENLVNLIEVF 3 8.2 0.97395 0.041303 0 0 0 0 0 0 8.31755 0 0 0 0 0 0 0 0 A0A8P0TSA5 A0A8P0TSA5_CANLF Exosome component 4 EXOSC4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178] RKSCEMGLHLRQT;VLQADGGT 2 9.3 1.0016 -1.4095 0 0 0 0 0 0 0 0 0 0 9.35341 9.32468 9.62114 0 0 A0A8P0TSB4 A0A8P0TSB4_CANLF Centromere protein J CENPJ Canis lupus familiaris (Dog) (Canis familiaris) ELNSGQSFLTQ;ESDSSTDSEEQ;FLMPTSSELNSGQS;GEDILPCWEK;GNEDECEITPDQPDSAFSPEG;QSISEDQPLFKMDR;TQCNHSEAPDCT;VLREKIIELETE 8 9 1.001 -0.9231 11.6339 11.5504 0 0 8.40182 6.7137 0 7.91313 0 0 9.02112 8.14027 10.0501 0 0 A0A8P0TSB5 A0A8P0TSB5_CANLF "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase" MGAT3 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation [GO:0006487] membrane [GO:0016020] "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0003830]" DLLDVRFHE;LVSSFFWNNAPVTPQ;PYQEPKSTAEGGR;TVDMLQTVYGL 4 7.4 0.98863 -0.30747 11.8293 0 0 0 0 0 0 0 0 0 12.2139 0 9.32933 0 11.5216 A0A8P0TSB9 A0A8P0TSB9_CANLF Melanophilin MLPH Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886] metal ion binding [GO:0046872]; small GTPase binding [GO:0031267] GDSEQTDEDGELGTV;QAGHAGGV;QRDFDLRRKEEER;SAHLNETHC;TPAESQIIGLGLSK 5 8.3 0.99011 -0.26592 0 11.0899 0 0 0 0 11.6991 0 0 0 0 0 0 0 0 A0A8P0TSC4 A0A8P0TSC4_CANLF SUN domain containing ossification factor SUCO Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DEWKKKVMEVEKEKS;ESPIVQLVQEEE;KDFLVSISDR;LDEIEKSGTIPIAKPSETEQSETD;QIFCSELTTIC;YVKVELVSHFGSEHF 6 7.1 1.0015 -0.70211 10.8945 7.47525 0 0 0 0 8.93245 0 8.70498 0 0 0 0 11.5242 0 A0A8P0TSD3 A0A8P0TSD3_CANLF Endothelin-3 (Preproendothelin-3) EDN3 Canis lupus familiaris (Dog) (Canis familiaris) regulation of vasoconstriction [GO:0019229]; vasoconstriction [GO:0042310] extracellular region [GO:0005576] EQASKGGPVHGRARRCTCFTYKDK;FGKGGGGV;SERMAEVADVTE;TPPTARSEGDIQ 4 17.7 1.0032 -1.0318 0 0 0 0 0 0 12.1944 0 0 11.2798 0 0 0 9.02173 0 A0A8P0TSE4 A0A8P0TSE4_CANLF Tubulin polymerization-promoting protein family member 3 TPPP3 Canis lupus familiaris (Dog) (Canis familiaris) microtubule polymerization [GO:0046785] microtubule [GO:0005874] tubulin binding [GO:0015631] KSKEEAFDAVCQLVAGK;NWAKLCKDCKVAD;QDILDDSGYVFDMSSGC 3 27.8 0.98954 -0.21877 0 0 0 6.99729 4.66352 0 0 0 0 0 0 0 0 0 0 A0A8P0TSE8 A0A8P0TSE8_CANLF P2X purinoceptor P2RX7 Canis lupus familiaris (Dog) (Canis familiaris) response to ATP [GO:0033198] plasma membrane [GO:0005886]; postsynapse [GO:0098794] ATP binding [GO:0005524]; extracellularly ATP-gated monoatomic cation channel activity [GO:0004931]; purinergic nucleotide receptor activity [GO:0001614] LDSWFHHCRP;MSACCSCN;RSHIYPCFKCCE;SSNSPDWCQCGHCLP 4 7.9 1.0022 -1.2992 0 0 0 0 0 10.1209 0 0 0 7.02912 0 0 0 0 0 A0A8P0TSF7 A0A8P0TSF7_CANLF Unc-13 homolog D UNC13D Canis lupus familiaris (Dog) (Canis familiaris) exocytosis [GO:0006887] endosome [GO:0005768] IKIRRRRVRDL;LLAYGLSL;LLRQAIKIRRRRV;TYPALNGDPILQ;VRLQDLHCREDQWYPL 5 4.8 0.98745 -0.40569 3.25278 0 7.06587 0 0 8.19441 6.97407 0 0 0 0 0 0 0 0 A0A8P0TSF8 A0A8P0TSF8_CANLF formate--tetrahydrofolate ligase (EC 6.3.4.3) MTHFD1L Canis lupus familiaris (Dog) (Canis familiaris) tetrahydrofolate interconversion [GO:0035999] ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] CFYDIDLDTETEQVKG;EQQHARWRL;FGVKGGAAGGGYA;PPTPARASGGGGGGCGGGEGLLGQ 4 6.7 1.0011 -0.74495 0 0 0 0 0 11.2181 5.64036 0 0 0 9.97985 0 0 0 0 A0A8P0TSG3 A0A8P0TSG3_CANLF Peptidase S1 domain-containing protein LOC482646 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] KMTIIPVSRIIPYSDFQGN;VGQWPWQVSI;VQLKNSTSCW 3 12.5 1.003 -0.86951 0 0 0 8.33981 0 9.25477 0 0 0 0 7.1815 0 0 0 0 A0A8P0TSG7 A0A8P0TSG7_CANLF TOX high mobility group box family member 3 TOX3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] GLHMDQSHTQVPQYRQDHSLIM;LFIQLTLKQCKFEFHGSTYMWMFWF;LPSQGSEFTPQ;PLTMRLPMNQ;PQPASQQHQSQI;SSMGTTLVGSTSSTQVS;TTINQSQLSAQLGLN 7 19.3 0.97714 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 7.17243 0 0 A0A8P0TSH6 A0A8P0TSH6_CANLF "Troponin I1, slow skeletal type" TNNI1 Canis lupus familiaris (Dog) (Canis familiaris) troponin complex [GO:0005861] actin binding [GO:0003779] AKECWEQEHEEREAE;PVTLSHGLGQE;VEVVDEERYD 3 18.6 1.0031 -0.85889 0 0 0 0 0 0 0 0 0 0 0 8.17612 0 0 0 A0A8P0TSI5 A0A8P0TSI5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) ICCLMISFHSPRGLTQSHLQ;VHSRICQCPQRHPSPQ 2 15.8 0.91304 0.11114 0 0 0 0 8.29126 0 0 0 0 0 0 0 0 0 10.5083 A0A8P0TSI6 A0A8P0TSI6_CANLF HECT domain E3 ubiquitin protein ligase 3 HECTD3 Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin-protein transferase activity [GO:0004842] DLIHFLYDHL;HFLYDHLGKEDENLGSVKQYVES;IDTPDHLQRQQQLFGVDYRPV;LADMSEELCPSSADTP;LLTWQELEKKVC;SIDVSSYTEEFNV;VFTQVYEGL 7 12.2 1.002 -1.2177 8.96711 0 12.7935 0 12.271 8.50466 8.78656 9.01589 13.4906 9.08531 0 0 0 7.21878 0 A0A8P0TSI8 A0A8P0TSI8_CANLF TOX high mobility group box family member 3 TOX3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677] FLIFLHINI;GLHMDQSHTQVPQYRQDHSLIM;LPSQGSEFTPQ;PLTMRLPMNQ;PQPASQQHQSQI;SSMGTTLVGSTSSTQVS;TTINQSQLSAQLGLN 7 16.4 1.0019 -1.8134 10.9899 0 0 0 0 0 0 0 0 0 0 0 0 0 13.7805 A0A8P0TSJ2 A0A8P0TSJ2_CANLF Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) SNRPD2 Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] cytosol [GO:0005829]; small nuclear ribonucleoprotein complex [GO:0030532] EKLLKCPVLS;LEKLLKCP 2 9.2 0.99013 -0.53526 0 0 13.5534 0 0 0 0 0 0 0 0 0 13.2429 0 0 A0A8P0TSJ6 A0A8P0TSJ6_CANLF Interleukin-1 receptor-associated kinase-like 2 IRAK2 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] AEVCGSVAAVEERLRGQETLLP;GMRQATVQQLVDLLRRLQLYRAAQ;GSIEKFFQ;SSNVLLDQNFIPK;TQLRKIKSMERVQGVSITRELLWW 5 14.9 0.99327 -0.0079597 12.2402 0 0 7.34279 7.36413 11.2802 0 0 0 6.60936 0 5.01699 12.2964 0 0 A0A8P0TSJ8 A0A8P0TSJ8_CANLF "Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Ubiquitous mitochondrial creatine kinase)" LOC478277 Canis lupus familiaris (Dog) (Canis familiaris) phosphocreatine biosynthetic process [GO:0046314] mitochondrial inner membrane [GO:0005743] ATP binding [GO:0005524]; creatine kinase activity [GO:0004111] EPVRAASERRRLYPPSAEYPD 1 5.2 0.976 0.047759 0 0 0 8.69129 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TSK2 A0A8P0TSK2_CANLF WD repeat domain 33 WDR33 Canis lupus familiaris (Dog) (Canis familiaris) mRNA 3'-end processing [GO:0031124] membrane [GO:0016020]; nucleus [GO:0005634] ETILQAHDSPVRAM;LFSFMVNNVY;QRDQRDMRAIQPD 3 11.3 0.99006 -0.1964 0 0 0 0 0 0 0 0 0 0 10.0871 0 0 0 0 A0A8P0TSK5 A0A8P0TSK5_CANLF Toll interacting protein TOLLIP Canis lupus familiaris (Dog) (Canis familiaris) ubiquitin binding [GO:0043130] GVVPVALP;TQPRCSEEDLKAIQ 2 10.4 0.98996 -0.20123 8.80916 7.55028 0 0 0 0 0 0 0 0 0 7.91654 14.1323 0 0 A0A8P0TSM3 A0A8P0TSM3_CANLF "Testis expressed 14, intercellular bridge forming factor" TEX14 Canis lupus familiaris (Dog) (Canis familiaris) attachment of spindle microtubules to kinetochore [GO:0008608]; intercellular bridge organization [GO:0043063]; male meiotic nuclear division [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint signaling [GO:0007094] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ACCFCDEDES;CFCDEDES;DEIEHLKQQ;DIRYILKNDLKDF;EACCFCDED;EACCFCDEDE;EACCFCDEDESSSE;FGKFYLMGGAQLAYLGSLPVIGE;KSLDSFLTSSE;PKVQRYELHPD;QEECRSLWASSREFAN;QEHSSKLRHPHLLQ;QEILTDNIPWNG;RSQFPVLHMEVIV;SSEAGTELSFEDWDWQ;TVKELNLPTHPHC;VKVKKILKK;YELHPDVNVYLGL 18 12.4 1.0047 -0.80421 0 0 4.34802 0 0 0 0 0 0 0 6.76646 0 7.7126 0 0 A0A8P0TSM4 A0A8P0TSM4_CANLF Secreted protein Canis lupus familiaris (Dog) (Canis familiaris) FAFVDVSCK 1 6.8 1.0038 -0.80421 0 0 0 0 0 0 0 0 8.26242 0 0 0 0 0 0 A0A8P0TSM6 A0A8P0TSM6_CANLF Solute carrier family 38 member 6 SLC38A6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] FGVVGSSTSACLIFVF 1 4 0.96035 0.049233 0 9.57399 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TSN5 A0A8P0TSN5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) keratinization [GO:0031424] GSGCCGGGSSQSSGGCC;SGGGGCCGS;SSCCSVSSGGCCGSSSGGGGCC;SSGGCCGSSSGGGGCCG;SSGGGGCC;SSGGGGCCG;SVSSGGCCGSSSGGGGCCGS;SVSSGGCCGSSSGGGGCCGSSSGG 8 46.2 1.0003 -2.8183 6.60097 6.74913 5.70371 6.22221 6.64746 6.75208 0 7.73227 7.49585 0 0 0 0 5.14396 0 A0A8P0TSN8 A0A8P0TSN8_CANLF Zinc finger and BTB domain containing 21 ZBTB21 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] AVAQKAPV;DTLFYHAPPL;EGLLHYINPAHAIS;ERLCRNATVCPYCSLRFFS;HCLKIFRSTAGLHRHV;PQESDTLFYHAPPLSA;SPTGLAEHPAPSTE 7 8.2 1.0023 -1.2261 9.31599 0 0 8.07863 0 0 9.85971 9.73877 7.35526 0 7.5012 0 8.61611 0 0 A0A8P0TSP2 A0A8P0TSP2_CANLF 5-hydroxytryptamine receptor 2C HTR2C Canis lupus familiaris (Dog) (Canis familiaris) feeding behavior [GO:0007631]; locomotory behavior [GO:0007626] plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993] DHILPDHPRSSPS 1 5.2 0.94631 0.077938 0 0 0 0 0 10.736 0 0 0 0 0 0 0 0 0 A0A8P0TSP4 A0A8P0TSP4_CANLF SH3 domain-containing protein MIA Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] FLVLLERGRAEG 1 6.9 0.98923 -0.26318 0 0 0 0 0 0 0 8.68282 0 0 0 0 0 0 0 A0A8P0TSP7 A0A8P0TSP7_CANLF Poly(A) polymerase (EC 2.7.7.19) PAPOLB Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA 3'-end processing [GO:0031123] nucleus [GO:0005634] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723] MVMIEEFKQGL;PQQNSTYNVSVSTRMV;TALSDGSLDLSAASEDSMSVP;YHLMPIITP 4 8.1 0.9439 0.083293 0 0 0 0 0 0 0 8.5678 0 0 0 8.26552 0 0 0 A0A8P0TSQ2 A0A8P0TSQ2_CANLF BCL2 interacting protein 3 BNIP3 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of apoptotic process [GO:0043065] membrane [GO:0016020]; mitochondrial envelope [GO:0005740] identical protein binding [GO:0042802] DWSSRPENIPP;SPAVRLSQAAHRRQRGL 2 12.6 0.99301 -0.16526 0 0 0 0 0 0 0 0 0 0 0 0 11.0318 0 0 A0A8P0TSQ4 A0A8P0TSQ4_CANLF Ubiquitin-like-conjugating enzyme ATG10 (Autophagy-related protein 10) ATG10 Canis lupus familiaris (Dog) (Canis familiaris) autophagy [GO:0006914] ubiquitin-like protein transferase activity [GO:0019787] CSEGYMCKTHF;GSGAERSGDCSE;TCLPMEEALELPLD 3 9.8 0.99148 -0.54528 0 0 0 6.51234 0 0 0 0 0 0 0 2.3356 0 0 0 A0A8P0TSQ5 A0A8P0TSQ5_CANLF Sodium/nucleoside cotransporter SLC28A1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] nucleoside transmembrane transporter activity [GO:0005337] AGSLLGAYISFGID;LVYPEVEESKFRSPE;RQAFQSTNPEVSRG 3 7.1 0.98509 -0.43746 9.72591 0 0 0 0 0 0 0 11.3272 0 9.60563 0 0 0 0 A0A8P0TSR3 A0A8P0TSR3_CANLF "ES1 protein homolog, mitochondrial" GATD3 Canis lupus familiaris (Dog) (Canis familiaris) CRVHEDVERVLKE;EAAAVLVHL;GAKHCVKEVTEAHVDKK;HQIWPAWTSQRSPLACAPAHVL 4 13 0.88107 0.13827 10.6704 0 0 0 0 0 0 0 0 0 0 0 11.1531 0 0 A0A8P0TST4 A0A8P0TST4_CANLF Solute carrier family 25 member 22 SLC25A22 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743] SLPTAVSPRTPL;VNLTLVTPEKAI 2 5.8 0.94323 0.05044 3.67841 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TST7 A0A8P0TST7_CANLF Protein mago nashi homolog 2 MAGOH Canis lupus familiaris (Dog) (Canis familiaris) RNA splicing [GO:0008380] exon-exon junction complex [GO:0035145]; spliceosomal complex [GO:0005681] SPLPPYEPWR 1 5.4 0.9995 -0.61146 0 0 0 0 0 0 0 10.4395 0 0 0 0 0 0 0 A0A8P0TSU8 A0A8P0TSU8_CANLF Ubiquitin specific peptidase 24 USP24 Canis lupus familiaris (Dog) (Canis familiaris) protein deubiquitination [GO:0016579]; proteolysis [GO:0006508] cysteine-type deubiquitinase activity [GO:0004843] AARVAIQTME;AAYEVLVMLADSSPSNLQ;ATKLKHPYYPCMAKVSLQLAIQ;ESDENCKRFMDRCM;FGEGNMFAVSPVSTFQK;GGGGDGGG;ITLRVRKLLLLIP;ITLRVRKLLLLIPTDP;LFQTYLRTKKKLRV;RITLRVRKLLLLI;SLIAGEAL;VRKLLLLI;YDQTNPYTDVRRRYWNAYML;YVPENFWKIFKMWNKELYVREQQDA 14 6.7 1.0022 -1.3013 0 8.36501 7.98254 10.5482 0 7.05528 8.296 9.36905 8.96596 0 0 6.83845 0 0 5.78827 A0A8P0TSV1 A0A8P0TSV1_CANLF Synaptotagmin 16 SYT16 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] IVLLVVLFLFINKKIYLEKI;RNLAVNRAPDTYGKL;SIRRGQPNPVYK;VGNSRHHGTSP 4 8.9 0.87484 0.13759 0 0 0 0 0 0 7.33244 3.62714 0 0 0 0 0 0 7.19889 A0A8P0TSV7 A0A8P0TSV7_CANLF Cysteine and serine rich nuclear protein 1 CSRNP1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DLGGEEEEEEEGGVG;EDCGCRCDRVCDPETC;RREKLRLRLK;SREDCGCRCDRVCDPETC 4 7.7 0.99207 -0.17107 8.87517 0 0 0 4.82038 0 5.38132 0 0 0 0 0 0 0 0 A0A8P0TSW2 A0A8P0TSW2_CANLF Ubiquitin conjugating enzyme E2 O UBE2O Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524] HVGRTCMVKWF;IGEEEDVSVYDIADH;KAEWPSETPVL;PVDMQDEGSEEAQ;SGASSDEWEDDSD;SSDEWEDDSD;TSGASSDEWEDDSDSWETDNG 7 5.8 1.0023 -1.2231 6.87566 9.50044 0 0 0 0 0 11.6945 0 0 8.23424 0 0 7.46597 2.92556 A0A8P0TSW4 A0A8P0TSW4_CANLF Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) PPP1R1B Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737] protein phosphatase inhibitor activity [GO:0004864] DDDEEEEEDSQ;DEEEEEEDDDDEEEEEDSQ;DEEEEEEDDDDEEEEEDSQAE;DLALNEPGEGPQ;EDLPGLLVKLQGPRPRRVKARV;EEEDDDDE;EEEEEDDDD;EEEEEEDDDDEEEEEDSQAEV;REEDEEEEEEDDDDEE;REEDEEEEEEDDDDEEEEE;YPREEDEEEEEEDDDDEEEE 11 14.9 0.86613 0.18589 8.01363 0 0 4.43896 7.60511 5.31604 6.1505 9.41378 6.58883 0 0 0 0 0 7.62739 A0A8P0TT01 A0A8P0TT01_CANLF Ig-like domain-containing protein LINGO3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EPGAFANLPRLRVLRLRGNLLKLI;LVSTAMGCITFLGVVLFCF;TYTCVASNAGGN 3 9.3 1.003 -0.80174 0 0 9.73378 0 0 0 0 0 0 10.0102 0 5.0578 0 0 0 A0A8P0TT06 A0A8P0TT06_CANLF Cyclin and CBS domain divalent metal cation transport mediator 2 CNNM2 Canis lupus familiaris (Dog) (Canis familiaris) EPAGAAAW;YGCGLVIPECL 2 4.2 1.0037 -1.0689 0 0 0 0 0 0 0 0 10.576 0 0 0 0 0 0 A0A8P0TT16 A0A8P0TT16_CANLF Protein HGH1 homolog HGH1 Canis lupus familiaris (Dog) (Canis familiaris) EVQVPEDVERQLQRLDQQEQEQHSR;GGLSPSAPRMPE 2 9.1 0.942 0.085978 0 0 0 0 0 0 9.86485 8.4048 0 0 0 0 0 0 0 A0A8P0TT20 A0A8P0TT20_CANLF LIM and senescent cell antigen-like-containing domain protein LIMS2 Canis lupus familiaris (Dog) (Canis familiaris) focal adhesion [GO:0005925]; plasma membrane [GO:0005886] metal ion binding [GO:0046872] CEHDFQMLFAPCCGSCGE;DVCYNCSHVIEGD;ESILKISVS;IVNSNGELYHE;NALGKQWH;VVNALGKQWH;YEKFPLELKKRLKK 7 19.4 0.91657 0.12036 0 0 0 0 8.92324 0 0 0 0 4.14828 0 0 0 0 0 A0A8P0TT43 A0A8P0TT43_CANLF Keratin 4 KRT77 Canis lupus familiaris (Dog) (Canis familiaris) keratin filament [GO:0045095] structural molecule activity [GO:0005198] AAAGFGAGSFGAGFGAGN;DKGRLQSELKTT;GGGGGGGG 3 7 0.98631 -0.41766 0 0 0 0 0 0 9.8799 10.2531 0 0 0 0 0 0 0 A0A8P0TT44 A0A8P0TT44_CANLF Olfactory receptor OR5M13 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] MLTVMAYDRYVA;VSPMLNPFIYSLRNKDVKNAIRKVF 2 11.9 0.97675 0.035538 0 0 11.4915 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TT45 A0A8P0TT45_CANLF SH3 and multiple ankyrin repeat domains 1 SHANK1 Canis lupus familiaris (Dog) (Canis familiaris) postsynaptic density [GO:0014069] AAGGGGGG;ASPPAARRSL;FDIRGSPTGGA;FEKGVPYLEFR;GGGGGGGG;GGSGTPGPPYHPQLMT;GVGPLLLQLGP;LSESLQDVLNY;PFQVAVIAGN;SFDAPSDYIIKEKTV;TRHPDMDEVHK;VLSIGEGGFWEGQVKGRIG;VPGSEDIPPPPT 13 7.1 0.9518 0.0539 0 8.86635 0 0 0 0 0 0 10.3737 0 0 0 0 0 0 A0A8P0TT55 A0A8P0TT55_CANLF Uncharacterized protein HDGFL3 Canis lupus familiaris (Dog) (Canis familiaris) KVIDLISLFGCM;TTRRLYIWL 2 10.3 0.98973 -0.26603 0 0 0 0 0 0 0 0 0 0 0 0 12.0771 0 0 A0A8P0TT58 A0A8P0TT58_CANLF Cadherin like and PC-esterase domain containing 1 CPED1 Canis lupus familiaris (Dog) (Canis familiaris) DENTEKSQVPLNATEN;DTFTITMGRYKEFLQG;ELNPEFNPKIKDYYSEVPF;ETELRLHQHILTQHRYT;IGDSTNRGIMY;LRRTGKPPS;VGGVQWLNANHLQII;YSYYPQFWMSPAL 8 12.1 1.002 -1.2293 9.82983 9.23981 9.90596 0 0 0 8.30793 0 11.9267 0 0 0 6.88582 0 11.5072 A0A8P0TT63 A0A8P0TT63_CANLF Thyroglobulin type-1 domain-containing protein TACSTD2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LPSPPPPPPLLLLLPPLLLLLAAAT 1 7.6 0.97693 0.035538 0 0 6.1843 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TT81 A0A8P0TT81_CANLF Exosome component 1 EXOSC1 Canis lupus familiaris (Dog) (Canis familiaris) RNA processing [GO:0006396] cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730] RNA binding [GO:0003723] EFRKVARVQPEFL;RKEDVRATEKDKVEIY 2 10.2 0.95647 0.049233 7.04494 0 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TT86 A0A8P0TT86_CANLF Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) PRP4K PRPF4B Canis lupus familiaris (Dog) (Canis familiaris) "mRNA cis splicing, via spliceosome [GO:0045292]" ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] EQESSSDDNLED;LRLFRHFYHKQHLCLVFEPLSMN;RRRTSRSPIRRRSRSPLRRSRS 3 6.1 0.99066 -0.51583 0 10.6624 0 0 0 0 0 0 9.20953 0 0 0 0 0 0 A0A8P0TT88 A0A8P0TT88_CANLF Coiled-coil domain containing 197 CCDC197 Canis lupus familiaris (Dog) (Canis familiaris) MLLQELWRLQAKQRRLER;VEHYEKLFIV 2 10.6 0.99359 -0.19122 8.45459 0 0 0 0 0 0 0 0 0 0 0 0 9.87771 0 A0A8P0TT93 A0A8P0TT93_CANLF Flavin-containing monooxygenase (EC 1.-.-.-) FMO2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]" IERFKGQYLHSR;LSLLLKDPKLAVKLYF;RHGSWVMSRISE;SAILTQKQRILKPLKT;VEEEIDVIVFATGY 5 13.5 0.99176 -0.54239 9.21859 0 0 0 5.89329 0 0 0 0 0 10.63 0 0 0 5.71595 A0A8P0TT98 A0A8P0TT98_CANLF Immunoglobulin V-set domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) RLIIIVSPLISRLVL 1 9.9 0.9525 0.053874 0 5.47492 0 0 0 0 0 0 0 0 0 2.38805 0 0 0 A0A8P0TTA0 A0A8P0TTA0_CANLF 15-oxoprostaglandin 13-reductase (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) PTGR1 Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin metabolic process [GO:0006693] LEKYVCPLSPAG;VLPHSSFAPG 2 8.4 0.98977 -0.21145 8.47496 0 0 0 0 0 0 0 10.6326 0 0 0 0 0 0 A0A8P0TTA4 A0A8P0TTA4_CANLF Coiled-coil domain containing 141 CCDC141 Canis lupus familiaris (Dog) (Canis familiaris) DEVQYIIKESEELS;FPEPTLTWWVAYNDKSY;GPKAGAKP;LEFAIKIDQA;NEVTCWFQKTIRDLQ;QAYVAFLQSSEEVQEQCQGLK;RRRQLDKDLKHQQQE;TRDYEDILYKVVQF;VSALDLGGSLQ 9 9.1 0.98631 -0.25964 0 0 0 0 0 0 11.3401 0 0 0 0 0 0 0 0 A0A8P0TTA7 A0A8P0TTA7_CANLF Prolyl 3-hydroxylase family member 4 (inactive) P3H4 Canis lupus familiaris (Dog) (Canis familiaris) CLAGCEGAHEQVDFKDF;ESGAILASPRPHS;GAWAAAGA;HYALFKANRL 4 11.3 1.0022 -0.76587 7.40335 0 10.0312 0 0 0 0 0 0 0 0 0 6.24529 0 6.30014 A0A8P0TTA8 A0A8P0TTA8_CANLF Retina and anterior neural fold homeobox RAX Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" GGGGGGGG;LRSPGGSTSRLHSI;PGGGGGGG 3 6.8 0.98984 -0.21988 0 8.75679 0 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TTB9 A0A8P0TTB9_CANLF LIM domain binding 1 LDB1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] LIM domain binding [GO:0030274] FFEDDAMLTIT;GPKRYTIGRTLIPRYFRSIF;LSNSTLNYLRLCVILE;NWTEECDNLWWDAFTTEFFEDDA;RLITRLENTQ 5 18.5 0.98508 -0.44393 0 0 0 4.0401 0 0 4.81614 0 0 0 7.55566 0 6.38864 0 0 A0A8P0TTC7 A0A8P0TTC7_CANLF Prune exopolyphosphatase 1 PRUNE1 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462] KGCAVASR;LSAYFDSMKIPSGQPE 2 4.4 0.98735 -0.49811 0 8.40731 0 0 0 0 0 0 8.73356 0 8.07227 8.30611 0 8.33387 0 A0A8P0TTD1 A0A8P0TTD1_CANLF Protein MIS12 homolog LOC102154136 Canis lupus familiaris (Dog) (Canis familiaris) mitotic cell cycle [GO:0000278] kinetochore [GO:0000776]; nucleus [GO:0005634] AQFFRFTVQTCMLRI;MEQLFLQLILCIPPNIL 2 15.5 0.98797 -0.46975 0 0 0 0 0 0 0 0 0 0 0 0 9.50869 9.50581 0 A0A8P0TTD3 A0A8P0TTD3_CANLF G-protein coupled receptors family 1 profile domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TVWSERGLHTPMYLFLC 1 5.2 0.98642 -0.25964 0 0 9.67124 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TTD5 A0A8P0TTD5_CANLF Olfactory receptor OR52A16 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AFNTYIAHICVFLEF 1 4.7 0.94855 0.05391 0 0 7.16159 0 0 0 7.56247 0 0 0 0 0 0 0 0 A0A8P0TTE2 A0A8P0TTE2_CANLF Lymphocyte antigen 6 family member G5B LY6G5B Canis lupus familiaris (Dog) (Canis familiaris) DYCNSWSSPQL;QAQCCQYDYCNSWSSPQLH 2 13.1 0.99178 -0.20762 5.84388 0 0 0 0 0 0 0 0 0 0 0 0 0 11.5353 A0A8P0TTF2 A0A8P0TTF2_CANLF Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) NMT1 Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; membrane [GO:0016020] glycylpeptide N-tetradecanoyltransferase activity [GO:0004379] AKKKKKKQKKK;AKKKKKKQKKKK;GAKKKKKKQKKKKEK;PANDTGAKKKKKKQKKKK;TGAKKKKKKQKKKK;VRVVSSRKLVGFISA 6 7.1 0.98974 -0.26403 0 0 0 0 0 0 0 0 10.0895 0 0 0 0 0 0 A0A8P0TTF6 A0A8P0TTF6_CANLF Family with sequence similarity 83 member C FAM83C Canis lupus familiaris (Dog) (Canis familiaris) EQAPEDRRLSPNQRHN;QRPEPGLPEGPTGG;VEELKRPWWRE;VEELKRPWWREA 4 7.5 0.9875 -0.46313 0 0 11.73 0 0 0 9.7901 0 0 0 0 0 0 0 6.6978 A0A8P0TTF7 A0A8P0TTF7_CANLF RING-type domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) metal ion binding [GO:0046872] ALPRPVQPPPSSPSPPERASGP;PGLQARRAHRRLRVRRLL;RRLRVRRLLLP;RRRRHRLVPRLALRVRPS;RRRRRHRLVPRLAL;SRRRRRRHRLVPRLALRVRPSAAA;VGGQHPGA;WLGPPGAIACPVCRHRT 8 16.8 1.0035 -1.0702 0 0 0 3.8522 6.68874 0 0 9.2564 0 0 6.45584 0 6.89603 8.7707 0 A0A8P0TTG5 A0A8P0TTG5_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) QIDDIVIAESSTNPN;YWTISGAFHTKL 2 21.3 0.9913 -0.20939 0 0 0 0 0 0 15.214 0 8.61036 0 0 0 0 0 0 A0A8P0TTM1 A0A8P0TTM1_CANLF Mitogen-activated protein kinase 15 (EC 2.7.11.24) MAPK15 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; MAP kinase activity [GO:0004707] EDLLALGSSYSASILPCL;GVQLSVPEYRRR 2 5.8 0.98906 -0.19906 0 0 10.569 8.01491 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TTM4 A0A8P0TTM4_CANLF BMP/retinoic acid inducible neural specific 3 BRINP3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of mitotic cell cycle [GO:0045930]; positive regulation of neuron differentiation [GO:0045666] FPDWERTKLDLPLQ;NDCWCQCGPKFPECNCPSMD;QICLTKNSTLEP;SEGEFICKDNDCWCQ;SNFQRRYEQ 5 8.4 1.0014 -0.64104 6.34003 0 0 5.51377 6.63607 0 0 0 0 0 9.60748 0 0 0 0 A0A8P0TTM9 A0A8P0TTM9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) LKCNYSSAVNSVQ 1 8.1 0.93945 0.059703 0 0 0 0 0 0 0 5.98229 0 0 0 0 0 0 0 A0A8P0TTN0 A0A8P0TTN0_CANLF Lysine-specific demethylase (EC 1.14.11.65) KDM3B Canis lupus familiaris (Dog) (Canis familiaris) demethylation [GO:0070988] histone deacetylase complex [GO:0000118] histone H3K9 demethylase activity [GO:0032454]; metal ion binding [GO:0046872] AAAGGDPGPALRT;AMMMVEPHQTEEMGDEEVF;KANCPCISRQN;QEIFSRGPY;QTEEMGDEEVF;SELKAIRP;TDTQKEVKEMVMGLNV;TEERPTVGPG;VGKRLLLL;VGKRLLLLFA;VLASSGFGAPL 11 6.3 0.99899 -3.2439 8.01218 0 0 3.21908 9.90251 0 0 0 0 0 0 0 0 11.3159 7.59872 A0A8P0TTN4 A0A8P0TTN4_CANLF Spermatogenesis and centriole associated 1 SPATC1 Canis lupus familiaris (Dog) (Canis familiaris) AYGILRERPELAASEGSSYSM;TPSSTPHITPYPPQSPTRAHHPTQ;VLAPAPTP 3 9.3 1.0023 -1.0132 0 0 0 0 7.8375 0 0 8.45992 0 0 0 0 0 0 7.52199 A0A8P0TTR0 A0A8P0TTR0_CANLF Cadherin 7 CDH7 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] CDADGIAQTCNAE;DNPPRFPRRSYQYNV;EEGPAAELPSRCRPLNPP;GAGGGGGG;GGGGGGGA;GGGGGGGG;ILACVLTLLVLILLIVTMRRRK;RKKKKKMKL;RLLHLSGRCGSPR;TLLVLILLIVTMRRRK;TRRNGFRRQEQSVYYLPI;VLTLLVLILLIVTMRRRKK 12 9.8 0.99654 -0.57908 10.5614 8.93044 9.60559 0 2.05516 0 0 0 0 0 0 0 8.93549 9.26113 0 A0A8P0TTR1 A0A8P0TTR1_CANLF tRNA methyltransferase O TRMO Canis lupus familiaris (Dog) (Canis familiaris) DRLFYFTVDIAH;GNRILFVF 2 4.6 0.9908 -0.21045 0 0 0 8.77933 0 6.13229 0 0 0 0 0 0 11.0951 0 0 A0A8P0TTR8 A0A8P0TTR8_CANLF EGF-like domain-containing protein DLL3 Canis lupus familiaris (Dog) (Canis familiaris) Notch signaling pathway [GO:0007219] membrane [GO:0016020] calcium ion binding [GO:0005509] APCALGAALSARGPVY;APLEDECEATPACRA;SQPEDWNHPEDGDS 3 7.6 1.0023 -0.7403 0 0 10.0808 0 0 0 0 0 0 10.4416 14.2217 0 0 0 0 A0A8P0TTS5 A0A8P0TTS5_CANLF Protein ripply3 RIPPLY3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DEEQEEETQS;RPEAAAGAREAR;VENGPGGK 3 18.3 0.94388 0.05044 0 0 0 0 0 0 0 0 0 0 8.91854 0 0 0 0 A0A8P0TTS6 A0A8P0TTS6_CANLF Fatty acid hydroxylase domain containing 2 FAXDC2 Canis lupus familiaris (Dog) (Canis familiaris) lipid biosynthetic process [GO:0008610] membrane [GO:0016020] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] EGAGMARKLAWSGE 1 2.9 0.98532 -0.24507 0 0 0 0 0 0 0 0 0 8.74406 0 0 0 0 0 A0A8P0TTT8 A0A8P0TTT8_CANLF "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2)" ALDH2 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial matrix [GO:0005759] "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]" DVDKVAFTG;EVFYNQIFINNE;WKLGPALA 3 6.1 1.0023 -1.0179 0 0 0 11.4915 0 8.90641 0 0 0 0 0 0 0 7.29866 0 A0A8P0TTU6 A0A8P0TTU6_CANLF Coiled-coil domain containing 150 CCDC150 Canis lupus familiaris (Dog) (Canis familiaris) AEAKEDNCKVTIMLENVLASH;AERIEALRKQFQTE;ALKESQKL;ARIIADHQAILQVEQKMMTQTFQE;ELSQAVKCRDVALKESQ;ESVNIISP;HVYLSHKISTW;IAGLKKERALNQQRVQKLEAEVDQW;LDHLILEHNQ;SLLGEKER;VLHRWENKQNLKLMPKKC 11 15.1 0.98114 0.035491 0 0 0 0 0 0 0 0 0 0 10.3837 0 0 0 0 A0A8P0TTU9 A0A8P0TTU9_CANLF Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6) ELOVL6 Canis lupus familiaris (Dog) (Canis familiaris) "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" endoplasmic reticulum membrane [GO:0005789] fatty acid elongase activity [GO:0009922] CSQPLRLAWGPHRARGRVGPAPE;GVQGSACS;PGELGRAACLLPPEARWPFAAA;SRRPPRWLPP;YLVFYWMQHDQCHSHFQN 5 14.9 1.0018 -0.95475 0 0 0 0 0 9.38373 8.58834 6.96382 9.96953 0 0 0 1.94819 0 0 A0A8P0TTV7 A0A8P0TTV7_CANLF "5-oxoprolinase, ATP-hydrolysing" OPLAH Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] ACFGGAGG;APETFVQLDQ;EDPVPPSGSPQ;EGGYQETPVY;LERRGERVALLVTRGFRDLL;LKLVLRNRGSSL;RLFFRSGLFVVG;SHLPDLTVITPVF;SSLGFCGSGLLAEVA;TDPEILESRYPVIVRRFE;VGAQLDPI 11 9.7 0.99918 -2.9264 10.1898 5.12474 11.792 0 0 0 12.1561 12.5209 9.71419 0 10.7648 11.0578 0 0 0 A0A8P0TTV8 A0A8P0TTV8_CANLF RNA-binding protein 8A RBM8A Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; RNA splicing [GO:0008380] cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] mRNA binding [GO:0003729] GWILFVTGVHEEATEEDIHDKFAEY 1 14.5 0.97507 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 6.84097 0 0 A0A8P0TTW7 A0A8P0TTW7_CANLF YTH domain containing 2 YTHDC2 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; helicase activity [GO:0004386]; RNA binding [GO:0003723] AQENTFKPESQRQR;GIWSTTPSNERKLNRAFWESSMVY;LAAIAVAERVAAERR;LERFRYGD;QVEQLISMGANVHSKASNGWMAL;VTMLKMVWIS;WQKARSDGWERAFC 7 8.1 0.99207 -0.54322 7.80723 0 0 8.99042 12.3001 0 0 0 7.56339 10.8445 5.40214 0 0 0 6.87061 A0A8P0TTW9 A0A8P0TTW9_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PEPSHLDLVWVFSLHT 1 6.1 0.95646 0.049233 0 0 0 0 8.99249 0 0 0 0 0 0 0 0 0 0 A0A8P0TTY9 A0A8P0TTY9_CANLF PID domain-containing protein NOS1AP Canis lupus familiaris (Dog) (Canis familiaris) FRFLPPPAGPLLGGLEL;GVKVILKKKKKK;GVKVILKKKKKKKE;GVKVILKKKKKKKEW;GVKVILKKKKKKKEWTW;LVMQDPIYRIFYVSHDSQDLKIFSY;VILKKKKKKKEWTW;VKVILKKKKKK;VKVILKKKKKKK 9 12.7 0.98924 -0.2655 0 0 0 0 0 0 0 11.0694 0 0 0 0 0 0 0 A0A8P0TU02 A0A8P0TU02_CANLF Cell division cycle 23 CDC23 GFRA3 Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169] anaphase-promoting complex [GO:0005680]; plasma membrane [GO:0005886] signaling receptor activity [GO:0038023] APPTALLLALLLLLLLLPRPL;IDVGFSKSSYI;LLLLLLLL;LLLLLLLLP;LLLLLLLP;TALLLALLLLLLLLPRPLR;TVDSLGPL;WTVHLARSLGDYE;YMYSRYLSGEKKKDDETVDSLGPLE 9 8 1.0022 -1.1736 0 0 0 0 0 0 7.10108 0 5.50284 0 6.5081 8.44074 5.01952 0 0 A0A8P0TU10 A0A8P0TU10_CANLF Destrin (Actin-depolymerizing factor) DSTN Canis lupus familiaris (Dog) (Canis familiaris) actin filament depolymerization [GO:0030042] actin cytoskeleton [GO:0015629] actin binding [GO:0003779] GSAVRRSLCKLGA;VLQRRPRRPPPLLPRPPRPR 2 7.9 0.92444 0.10804 0 0 0 0 0 7.4149 0 7.26219 0 0 0 0 0 0 0 A0A8P0TU17 A0A8P0TU17_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] VGFLSCMSSLMY;WLLCSMSSLMYNEITLH;YQPYLCWKA 3 25 1.0028 -0.84828 0 0 11.427 0 0 0 0 0 0 9.19118 0 0 0 0 0 A0A8P0TU52 A0A8P0TU52_CANLF Glucocorticoid modulatory element binding protein 1 GMEB1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872] FLYTLTELERQLEEQKK;VLSPSPPVQQPQ 2 5.6 0.99323 -0.16049 0 0 0 8.9367 0 0 0 0 0 0 0 0 9.52523 0 0 A0A8P0TU53 A0A8P0TU53_CANLF Nitric oxide synthase (EC 1.14.13.39) NOS2 Canis lupus familiaris (Dog) (Canis familiaris) nitric oxide biosynthetic process [GO:0006809] calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517] GEKLKKSLFMLKELTN;ILCQPSEYNKWKLTNSPTFLEVLEE;PILKPRYYSIS;PKYEWFREL;RLYTSNVTWDPHQYRL;RRPQRRKIQLKVLVKAVLFAS;SLVTQDDPKCHSL;VLSPFYYYQVEAWKTHVWQDEK 8 12.5 1.0035 -0.87644 9.59466 6.17145 0 0 0 9.71882 9.46742 0 9.99209 0 0 0 0 7.86059 9.37162 A0A8P0TU58 A0A8P0TU58_CANLF Cysteine rich hydrophobic domain 2 CHIC2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] TVWEIADLRFG 1 7 0.98133 0.035491 0 0 0 0 0 0 0 7.77518 0 0 0 0 0 0 0 A0A8P0TU62 A0A8P0TU62_CANLF "DM1 locus, WD repeat containing" DMWD Canis lupus familiaris (Dog) (Canis familiaris) NKPIDKRIYKGTQPTCHD;QDTQFCLWDLTE;WSFAEGRVVARGHGHK 3 8 0.98719 -0.40402 0 0 0 9.52726 0 0 0 0 0 0 0 0 0 9.58791 10.4703 A0A8P0TU63 A0A8P0TU63_CANLF Maestro heat like repeat family member 1 MROH1 Canis lupus familiaris (Dog) (Canis familiaris) DLHPVLLHVAIR;GDGRGAAS;NIFQYFSTKD;NVLHRNIHPLL;PPLLLGGL;YLLEFLTPTRFTGALTPL 6 4 1 -2.8365 0 0 0 0 0 0 5.62469 0 6.6768 11.1378 4.34674 4.43689 10.6705 10.5663 0 A0A8P0TU64 A0A8P0TU64_CANLF Canopy FGF signaling regulator 1 CNPY1 Canis lupus familiaris (Dog) (Canis familiaris) NIAETEFICDA 1 8.2 0.98481 -0.2461 0 8.97619 0 0 0 1.83891 0 0 0 0 0 0 0 0 0 A0A8P0TU78 A0A8P0TU78_CANLF SET nuclear proto-oncogene SET Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] nucleus [GO:0005634] FLLSLYIGLRDYTVSL;HRILAFFLL 2 5 0.95585 0.049233 0 0 0 0 0 0 0 9.01617 0 0 0 0 0 0 0 A0A8P0TUA0 A0A8P0TUA0_CANLF Zinc finger protein 8 ZNF8 Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] metal ion binding [GO:0046872] EGEGFLRD;SESSGGGT 2 3.1 1.0034 -1.6144 0 0 0 0 0 0 8.83589 0 0 0 0 0 0 0 0 A0A8P0TUA8 A0A8P0TUA8_CANLF V-SNARE coiled-coil homology domain-containing protein VAMP4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi ribbon formation [GO:0090161]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] EDDSDEEEDFF;LVAVILLLVIIILK;LVAVILLLVIIILKY;LVAVILLLVIIILKYR;QLRRQMWWRGCKIKAIMALVAVILL;VILLLVIIILK 6 32.6 0.99757 -0.088622 0 5.81785 0 4.16052 0 0 7.05961 0 0 0 4.50576 0 0 4.51891 4.86493 A0A8P0TUB2 A0A8P0TUB2_CANLF "Serum/glucocorticoid regulated kinase family, member 3" SGK3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine/threonine kinase activity [GO:0004674] KGSFGKVLLAKRKL;KHPFLVGL;SLMNFFFCNQVL 3 6.4 0.91388 0.11121 0 0 0 0 0 0 0 0 9.27826 0 0 0 0 0 8.81436 A0A8P0TUC4 A0A8P0TUC4_CANLF EGF like domain multiple 8 EGFL8 Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] TTYRVAWREVKREVQ;VGVSVRARAQW 2 7 0.9942 -0.079757 0 0 0 0 0 0 10.4592 0 11.2797 0 0 0 0 0 0 A0A8P0TUC8 A0A8P0TUC8_CANLF "RB binding protein 9, serine hydrolase" RBBP9 Canis lupus familiaris (Dog) (Canis familiaris) hydrolase activity [GO:0016787] ARESLWLPFMETELHCDEKTVIIGH;EEGAGAVT 2 16.4 1.0038 -1.0689 0 0 0 0 0 0 0 8.12603 0 0 0 0 8.86805 0 0 A0A8P0TUD7 A0A8P0TUD7_CANLF dTMP kinase (EC 2.7.4.9) DTYMK Canis lupus familiaris (Dog) (Canis familiaris) dTDP biosynthetic process [GO:0006233] ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798] PGRCQPIRARL;QQILFLCELCPNR 2 4.6 0.99262 -0.14018 0 0 0 0 0 0 0 0 11.3272 0 0 0 0 0 0 A0A8P0TUE0 A0A8P0TUE0_CANLF N-alpha-acetyltransferase 40 (EC 2.3.1.257) NAA40 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485] AGGHCGGCC;DSSPSMSGCCGEDC;EALQFEIDDSSPSMSGCCGEDCSYE;LESKVRRKGLGKF;SQHSHAGG 5 24.1 1.0018 -0.91395 0 8.49498 0 0 0 0 0 0 0 4.82293 0 5.28529 7.24536 5.40949 0 A0A8P0TUE9 A0A8P0TUE9_CANLF Olfactory receptor OR10X1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IMGLTWVD;RLACIDSNLTESIV;SVMGCGLQMCFFLGLGGTNC 3 13.5 1.002 -0.65635 0 0 10.2702 0 0 0 0 0 0 0 12.6308 0 0 0 12.8355 A0A8P0TUF7 A0A8P0TUF7_CANLF Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) PDGFRB Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] cytoplasmic vesicle [GO:0031410]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; platelet-derived growth factor beta-receptor activity [GO:0005019] AILALVVLTIISLIILI;DAVQFAELHR;DYLHRNKHTFLQ;FLTEITEITIPCRVTDPRL;IILIMLWQKKPRYE;LGACTKGGP;MLSPQASGGLVITPPG;VGVLIALAAGPVALHRY;VVWFKDNR 9 10.7 1.0034 -1.0345 10.1486 0 11.6221 0 5.94434 6.749 8.2363 0 3.38031 0 0 0 5.34092 0 0 A0A8P0TUF9 A0A8P0TUF9_CANLF RAD21 cohesin complex component like 1 RAD21L1 SNPH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DDLKMQLSRMQEDWIEEECH;EAQLALKEARKEIKQLKQVIDTVKN;EDWIEEECHRVEAQ;GSGPNERMTWPGPAL;PTPEQYLTPLQQKEVC;QPDMDTILEKVTKAQACGA 6 18 0.99393 -0.030517 0 0 0 4.47268 6.20895 0 10.4453 0 0 6.11214 0 0 0 0 0 A0A8P0TUH3 A0A8P0TUH3_CANLF Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) DGAT1 BOP1 Canis lupus familiaris (Dog) (Canis familiaris) "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" "nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]" ribonucleoprotein complex binding [GO:0043021] AYGRFIQERFE;EDSGSDSSE;KLVWFDLDLSCEPYRVLRH;REDSVLLLNPAL;RGQFGDVSFD;RVSARRRGRRGS;SGSDSSEDDPAEEEEEVSSDEG 7 9.7 1.0026 -1.8534 0 0 10.3968 5.63119 0 0 0 9.08369 0 0 8.97042 10.536 11.0907 0 0 A0A8P0TUL6 A0A8P0TUL6_CANLF F-actin-capping protein subunit alpha Canis lupus familiaris (Dog) (Canis familiaris) barbed-end actin filament capping [GO:0051016] F-actin capping protein complex [GO:0008290] actin binding [GO:0003779] DQVYAKAIDGQQTIIACIESHQ 1 13.8 0.97809 0.04781 0 0 7.88209 0 0 0 0 0 0 0 0 0 0 0 0 A0A8P0TUL7 A0A8P0TUL7_CANLF SEA domain-containing protein LOC106558870 Canis lupus familiaris (Dog) (Canis familiaris) cell periphery [GO:0071944]; membrane [GO:0016020] AASADITTSIA;AGTSTASPDMSTSTGS;GTTSAAATD;MTTSTAWPD;PEAITSTASPDV;PRCYCLSTDTDWY;RCYCLSTDTDWYSGETCE;SSVMSTSI;STSTVSPDRTTSSSAQDET;TASPVMSTSPVSPDTT;TTSPEVTSSTAWPVASTS;TVSPDMSTSTMSPDMST;TVSPDRTTS;VTISPALPEASTSI;WDGIKCVCVGLFQ;YILKRNIEDNTYND 16 6.4 0.99658 -4.8853 8.44898 0 8.55029 0 14.1827 6.01567 12.157 8.07895 10.3608 7.49937 12.1907 9.25541 0 6.36263 12.5745 A0A8P0TUL8 A0A8P0TUL8_CANLF Cysteine and tyrosine-rich protein 1 CYYR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] CSLSAQRIALLSV 1 4.7 0.94822 0.059561 0 0 0 0 6.89518 0 0 0 0 0 0 0 0 0 0 A0A8P0TUN0 A0A8P0TUN0_CANLF Torsin-1A-interacting protein 2 LOC610310 Canis lupus familiaris (Dog) (Canis familiaris) LELGHWLYQ;NRADYCPECYP 2 15.3 0.98699 -0.36488 0 0 0 0 0 0 10.5009 8.75592 0 0 0 0 0 0 0 A0A8P0TUN1 A0A8P0TUN1_CANLF V-SNARE coiled-coil homology domain-containing protein VAMP4 Canis lupus familiaris (Dog) (Canis familiaris) Golgi ribbon formation [GO:0090161]; vesicle-mediated transport [GO:0016192] membrane [GO:0016020] EDDSDEEEDFF;LVAVILLLVIIN;QLRRQMWWRGCKIKAIMALVAVILL 3 20 0.95362 0.05044 0 0 0 0 0 3.6722 0 0 0 0 0 0 0 0 0 A0A8P0TUP0 A0A8P0TUP0_CANLF adenylate cyclase (EC 4.6.1.1) ADCY6 Canis lupus familiaris (Dog) (Canis familiaris) cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556] plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] DEAFIRRGGP;GVSRGGQGEGQGGDDHLLPQWGPP;PEYFVGNMLLS;SSLTLLMAVLVLLTAVLLAFHAAPA 4 5.7 0.9723 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 9.5272 0 A0A8P0TUP2 A0A8P0TUP2_CANLF Erlin (SPFH domain-containing protein) (Endoplasmic reticulum lipid raft-associated protein) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein) ERLIN2 Canis lupus familiaris (Dog) (Canis familiaris) cholesterol metabolic process [GO:0008203] endoplasmic reticulum membrane [GO:0005789] ubiquitin protein ligase binding [GO:0031625] DLTSMAPG;IELFDQIDEN;IVKNYTADYDKAL 3 9.3 1.0017 -1.3088 0 0 0 8.60192 0 0 0 10.1463 0 0 0 0 0 0 0 A0A8P0TUQ2 A0A8P0TUQ2_CANLF Ig-like domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) TQPPSLSASPGTTARLTCTLSSG;VGDYDMYWYQ 2 28.2 0.99722 -0.59553 0 0 0 0 0 0 10.0475 0 0 0 0 0 0 0 0 A0A8P0TUS2 A0A8P0TUS2_CANLF Microtubule associated serine/threonine kinase family member 4 MAST4 Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674] DLIEKCDFI 1 4.8 0.98362 -0.2444 0 0 0 0 0 0 12.8041 0 0 0 0 0 0 0 0 A0A8P0TUS9 A0A8P0TUS9_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LLVLVLLILAILTGV;LVLLILAILTGVKWYLIGVLI 2 16.2 0.94196 0.10104 0 0 0 2.64501 0 0 0 6.5443 0 0 0 0 0 0 0 A0A8P0TUT6 A0A8P0TUT6_CANLF Protein phosphatase 4 regulatory subunit 1 PPP4R1 Canis lupus familiaris (Dog) (Canis familiaris) ADGFGVDDYSSESD;CEMCCDCRMFH;DFVSQDEMLTPLG;DTLREVCDDERDCIAVLE;LQEDADGFGVDDYS;TWPPGLRARRRRRRGGG;VGQQATEEMLLPRFFQ 7 9.2 0.99005 -0.21544 0 0 9.00385 0 0 0 0 0 0 0 0 0 5.15251 0 0 A0A8P0TUT9 A0A8P0TUT9_CANLF Prickle planar cell polarity protein 1 PRICKLE1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] zinc ion binding [GO:0008270] DLSSPTSALP;EDDDSWCSSTSSSSDSE;FEEMEAEDCEKMSNM;GRPFCCGCFESLYAEYCEACGEHI;GVCWHPSCFVCFTCNELL;IAVFASRAGPG;QSRPQQVKFSDDVI;TSSSSDSEEEGYF 8 13.6 1.0028 -1.1581 0 9.83627 0 7.29407 0 9.3085 0 8.66156 0 0 0 11.3082 0 7.35694 0 A0A8P0TUU7 A0A8P0TUU7_CANLF C2H2-type domain-containing protein ZNF660 Canis lupus familiaris (Dog) (Canis familiaris) IECGKAFSRS 1 3 0.98279 -0.24826 0 0 0 0 9.33925 0 0 0 0 0 0 0 0 0 0 A0A8P0TUV5 A0A8P0TUV5_CANLF Sperm-tail PG-rich repeat containing 4 STPG4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] QRNDPVLNDLPLYTPPDFLDL;YSFKDKPRSSPS 2 18.4 0.9922 -0.14405 0 0 0 0 0 0 11.6337 0 0 0 0 0 0 0 0 A0A8P0TUX7 A0A8P0TUX7_CANLF "Myosin regulatory light polypeptide 9 (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9)" Canis lupus familiaris (Dog) (Canis familiaris) calcium ion binding [GO:0005509] QNAFACFDEEASGFI 1 9.6 0.98964 -0.26403 0 0 0 0 7.88899 0 0 0 0 0 0 0 0 0 0 A0A8P0TUX9 A0A8P0TUX9_CANLF "Myosin-binding protein C, cardiac-type (C-protein, cardiac muscle isoform)" MYBPC3 Canis lupus familiaris (Dog) (Canis familiaris) myosin filament [GO:0032982] actin binding [GO:0003779] DDVTPADEADYSFV;DEADYSFVPEGF;TTQEPVTVQEI;VLQIVDKP;VMRPQDGE 5 3.6 1.0029 -1.7221 0 0 0 0 6.94228 0 0 0 8.90902 0 0 11.7195 0 0 0 A0A8P0TUY2 A0A8P0TUY2_CANLF "Cell division cycle 34, ubiqiutin conjugating enzyme" CDC34 Canis lupus familiaris (Dog) (Canis familiaris) DLFYDDYY;PPKGNGGP;YYEDGEAEAEADSCFGDDEDD 3 5.8 0.99018 -0.26592 11.932 0 0 0 0 0 0 11.8689 11.8437 0 0 0 0 12.2533 0 A0A8P0TV00 A0A8P0TV00_CANLF Neurofibromin 1 NF1 Canis lupus familiaris (Dog) (Canis familiaris) "nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; RNA surveillance [GO:0071025]" AKLKRLLKETAFKFKALKKV;EALLVLHQL;LLVLHQLDSI;QELTVCSEDNVDVHD;TFWEISLRFY;WNPDAPVETFW 6 11.4 0.99892 -0.61146 0 0 0 0 0 3.03295 0 0 0 0 0 0 0 0 0 A0A8P0TV25 A0A8P0TV25_CANLF Tetraspanin Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] PLGSGGVA 1 3.9 1.0042 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 10.0895 0 0 A0A8P0TV31 A0A8P0TV31_CANLF Polyadenylate-binding protein 5 PABPC5 Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] DVTEDMLYKK;PAGKKKKYLK 2 5.2 1.002 -0.90671 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.40531 A0A8P0TV33 A0A8P0TV33_CANLF Syntaxin-binding protein 1 (Protein unc-18 homolog 1) (Protein unc-18 homolog A) STXBP1 Canis lupus familiaris (Dog) (Canis familiaris) protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] cytosol [GO:0005829]; membrane [GO:0016020] VRYRGEYKDNALLA 1 2.5 0.93728 0.060916 0 0 0 0 0 0 0 0 0 0 0 2.75063 0 0 0 A0A8P0TV46 A0A8P0TV46_CANLF BTB domain containing 3 BTBD3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] AGFGLYGSSCGSAE;ITLKTKKKK;KKKKKMAADIFPRKKP;RSNQWRYRGRCDSIQ;VGPPGGTQ 5 11.1 1.0018 -1.3113 0 0 6.41231 0 0 0 11.6768 0 0 0 0 0 0 0 3.68829 A0A8P0TV47 A0A8P0TV47_CANLF Charged multivesicular body protein 4A CHMP4A Canis lupus familiaris (Dog) (Canis familiaris) vacuolar transport [GO:0007034] TTNAEVLRTME 1 5.1 0.98701 -0.2312 0 0 0 0 0 0 0 0 0 0 0 0 0 9.42162 0 A0A8P0TV94 A0A8P0TV94_CANLF SH3 domain-binding glutamic acid-rich-like protein 1 SH3BGRL Canis lupus familiaris (Dog) (Canis familiaris) cytosol [GO:0005829]; plasma membrane [GO:0005886] KSDSDMTKLYPMS 1 10 0.99346 -0.16498 0 0 0 0 0 0 0 0 0 0 0 0 12.9193 0 0 A0A8P0TVA8 A0A8P0TVA8_CANLF Endosomal transmembrane epsin interactor 2 ENTREP2 Canis lupus familiaris (Dog) (Canis familiaris) LADEEARARPETGGPAP;LEYRRIPHTDPVDYEFQWGPRTN 2 8.5 0.987 -0.22813 0 0 0 0 0 0 0 0 0 0 0 0 12.5138 5.95641 0 A0A8P0TVB4 A0A8P0TVB4_CANLF LKAAEAR motif containing 1 LKAAEAR1 Canis lupus familiaris (Dog) (Canis familiaris) KGAGRGGP 1 5.2 1.0038 -1.1044 7.13031 0 0 0 0 0 0 0 0 0 0 0 0 6.33999 0 A0A8P0TVF4 A0A8P0TVF4_CANLF Acyl-CoA 6-desaturase (EC 1.14.19.3) (Fatty acid desaturase 2) FADS2 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629] membrane [GO:0016020] "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]" APLAPPTHKAPPL;LGEWQPIE;PLAPPTHKAPPL;VGCPRGWGTDPI;VLGEWQPIEYGKK;VNMLHVFVLGEW 6 8.2 1.0025 -1.8986 0 0 0 0 0 0 14.2311 14.0861 14.1938 0 0 0 0 0 0 A0A8P0TVL9 A0A8P0TVL9_CANLF Gamma-aminobutyric acid type A receptor subunit alpha4 GABRA4 Canis lupus familiaris (Dog) (Canis familiaris) gamma-aminobutyric acid signaling pathway [GO:0007214] chloride channel complex [GO:0034707]; postsynaptic membrane [GO:0045211] chloride channel activity [GO:0005254]; extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890] EQRSGRSAGRAPLGSPRTQ;GRFPGGTRAPAG;VSYATAMDW 3 5.4 0.98927 -0.21841 0 0 8.53893 0 9.62876 0 0 0 0 0 0 0 0 0 0 A0A8P0TVP0 A0A8P0TVP0_CANLF L1 transposable element RRM domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) HYPARLSFKMEG;SETVLSPTELQNLD 2 8.7 0.94239 0.05044 0 0 0 0 0 0 0 9.19456 0 0 0 0 0 0 0 A0A8P0TVP4 A0A8P0TVP4_CANLF Ribonuclease (EC 3.1.26.4) RNASEH2A Canis lupus familiaris (Dog) (Canis familiaris) RNA catabolic process [GO:0006401] metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523] LPRGGHGG;SVAAAETSTV;VARDQAVKSWHF 3 6 1.0029 -0.8393 10.9543 0 0 0 0 0 11.0977 11.2705 0 9.79836 11.3903 0 10.7504 11.2158 0 A0A8P0TVR5 A0A8P0TVR5_CANLF "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase (EC 2.4.2.42)" GXYLT2 Canis lupus familiaris (Dog) (Canis familiaris) UDP-glycosyltransferase activity [GO:0008194] GVYHDDKQPTFKALYEAIRDFPFQ 1 5.9 0.99296 -0.29079 0 0 0 0 0 0 0 11.2951 0 0 0 0 0 0 0 A0A8P0TW30 A0A8P0TW30_CANLF Ring finger protein 213 RNF213 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842] CVCVCACACVCGCRGG;DLFLDGVSLRKT;EKHYLDINTVLE;GKPRITLMGIPTL;GLSKKLVEIF;GVVSVWSVDALAL;ICMETGKMVVLLNLQ;KLHETICSITKDE;LALGDWHQ;LEELWVQAQYITGAE;LGDWHQYDDMVRM;LLREENMLSQMDRYL;LLTHLALL;LVSYMETKDSEIPPELEY;NLSRILTIYPQILQVL;PEDLLVQARNWKGLET;PYIMVHNDMSP;RAVDTAERLGSIP;SDGCKALSVIEVTLGFLSTAGG;SLDAIHPSSGRVI;TYSMWCSPEP;VEYLQEMTRIRLCLNKAS;VIDPSWSELQNFAGF;VIMDGVRDEDLAPFSLRK;VLDRDSNLE;VLHMALWSCINQLHTQRP;VLPAALAIYRHM;VMHTLCKCKEQAS;VPLKVIRLI;YSMWCSPEPASEA;YTAEQLVYLSTQLKEQKP 31 8.1 0.99697 -6.054 11.8757 13.3464 10.2827 7.49562 0 11.2417 9.83246 0 9.82003 7.904 5.31947 9.47332 12.961 11.6843 8.16702 A0A8P0TW52 A0A8P0TW52_CANLF "Glycerol-3-phosphate dehydrogenase, mitochondrial (EC 1.1.5.3)" GPD2 Canis lupus familiaris (Dog) (Canis familiaris) glycerol-3-phosphate metabolic process [GO:0006072] mitochondrion [GO:0005739] calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368] DDFSSGTSSRS;GSGSRPTSEARGAEVGQPERAG;PAGRAAVLPASPAP;RGQGSGSRPIREARGAEVGQP;SERPGERKLANQ 5 4 0.98687 -0.38374 6.09432 0 0 2.23192 0 5.21202 0 0 12.6111 0 0 0 0 0 0 A0A9E7V458 A0A9E7V458_CANLF "60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (Heat shock protein 60)" HspD1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic mitochondrial changes [GO:0008637]; mitochondrial unfolded protein response [GO:0034514]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of T cell activation [GO:0050870]; positive regulation of type II interferon production [GO:0032729]; protein import into mitochondrial intermembrane space [GO:0045041]; protein refolding [GO:0042026]; T cell activation [GO:0042110] chaperonin-containing T-complex [GO:0005832]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; protein-folding chaperone binding [GO:0051087] AHRKPLVIIA;EEAGDGTT;FGDNRKNQLKDM 3 5.5 1.0029 -1.3793 0 0 0 0 7.87866 0 4.81291 0 0 0 0 0 0 0 0 A0A9J7R993 A0A9J7R993_CANLF Aurora kinase (EC 2.7.11.1) AURKA Canis lupus familiaris (Dog) (Canis familiaris) cell division [GO:0051301] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; neuron projection [GO:0043005] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] LRHPNILRLYGY 1 3.4 0.94498 0.05044 0 0 0 0 0 0 0 0 4.44969 0 0 0 0 0 0 A0A9Y1MWN1 A0A9Y1MWN1_CANLF X-linked retinitis pigmentosa GTPase regulator splice variant C RPGR Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] EQPESVEFSSG;EWGVREREEKDTEEE;GELEEEGEGELEEGEGK;IDGIPMPPVCFSPSPIP;REEEVGEEEET;SLSNLSSGIVLHQ;VGEEEETEGEGDKEGEE;VGEEEGEGEEEEEGE;VGEEEGEGEEEEEGEEEEGEE 9 8.4 1.0023 -0.6601 14.3174 10.2013 0 0 0 0 11.0227 0 10.2104 8.15502 0 10.3216 0 9.48309 7.80084 A0FGS8 A0FGS8_CANLF trypsin (EC 3.4.21.4) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] DQWVVSAAHCYKSRIQ;IMLIKLSSPAV;VGGYTCEENSVPYQVSL 3 18.1 0.98535 -0.44673 0 0 0 0 9.68478 9.89627 0 0 0 0 0 0 0 0 0 A0SYQ0 PTGES_CANLF Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal prostaglandin E synthase 1) (MPGES-1) PTGES PGES Canis lupus familiaris (Dog) (Canis familiaris) cell population proliferation [GO:0008283]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of prostaglandin secretion [GO:0032308]; prostaglandin biosynthetic process [GO:0001516]; regulation of fever generation [GO:0031620]; regulation of inflammatory response [GO:0050727]; sensory perception of pain [GO:0019233] membrane [GO:0016020]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471] glutathione binding [GO:0043295]; glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; prostaglandin-D synthase activity [GO:0004667]; prostaglandin-E synthase activity [GO:0050220] SLAYTVAQLPCASMALQI 1 11.8 0.97053 0.048313 0 0 0 0 6.01067 0 0 0 0 0 0 0 0 0 0 A1A437 A1A437_CANLF Protein-arginine deiminase (EC 3.5.3.15) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509]; protein-arginine deiminase activity [GO:0004668] EFPSADFSG;LSNGRQAN;LVERDIIDIPQLFCLEQ;NQLLADKNMRKQNDYVEKCI;PLENNLKETFYVEAIEF 5 10 1.0035 -2.0513 0 10.1906 0 8.20692 0 0 0 0 6.67158 0 0 9.02045 0 0 0 A1DZY5 A1DZY5_CANLF Direct IAP-binding protein with low pI (Second mitochondria-derived activator of caspase) Canis lupus familiaris (Dog) (Canis familiaris) intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402] mitochondrion [GO:0005739] EYTKAVYTLISLY 1 5.5 0.99026 -0.26643 0 0 0 10.2312 0 0 0 0 0 0 0 0 0 0 0 A1IGX8 A1IGX8_CANLF Cerebroside sulfotransferase (Galactose-3-O-sulfotransferase 1) GAL3ST1 CST Canis lupus familiaris (Dog) (Canis familiaris) glycolipid biosynthetic process [GO:0009247] membrane [GO:0016020] galactosylceramide sulfotransferase activity [GO:0001733] PLGAKSIL;VLRDPARLFESSFH;YFDESLVLLKDLLCWELEDVLYF 3 10.6 1.0021 -0.67921 11.1689 0 0 7.46948 0 0 0 0 0 0 0 0 0 0 0 A1ILJ0 A1ILJ0_CANLF Alpha 1 antitrypsin (Serpin family A member 1) SERPINA1 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] identical protein binding [GO:0042802]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867] DAVQETDDPEH;DAVQETDDPEHQPA;EAIPMSMPPSVDFNKPFL;EGLQGDAVQ;EGLQGDAVQE;EGLQGDAVQET;EGLQGDAVQETD;EGLQGDAVQETDD;EGLQGDAVQETDDPE;EGLQGDAVQETDDPEH;EGLQGDAVQETDDPEHQ;EGLQGDAVQETDDPEHQPA;EKPFEVEHTTEEDF;FMGKVVNPTQK;GKVVNPTQK;IIIVDRDTKSPLF;IIIVDRDTKSPLFMGKVVNPTQK;LEAIPMSMPPSVDFNKPFL;LQGDAVQETD;LQGDAVQETDD;MGKVVNPTQK;PLFMGKVVNPTQK;PPSVDFNKPFL;RDTKSPLFMGKVVNPTQK;SPLFMGKVVNPTQK;TIDEKGTEAAGATFL;TKSPLFMGKVVNPTQK 27 21.4 0 47.73 15.2189 15.3105 15.1376 14.9685 15.1396 15.0196 15.513 15.4932 15.5184 15.3127 15.2645 15.4708 15.3729 15.4525 15.2491 A1YV65 A1YV65_CANLF Carcinoembryonic antigen-related cell adhesion molecule 30 isoform 2L1 CEACAM30 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] DNSTLTIDP;STGLRLGSIIGIALGVLLGLALM 2 9.5 0.97833 0.046253 0 0 5.28792 0 0 0 0 0 0 0 0 0 0 0 0 A2BCP3 A2BCP3_CANLF "Alpha-2,8-sialyltransferase ST8Sia II (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2)" siat 8B ST8SIA2 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] sialyltransferase activity [GO:0008373] KTDLVTMNP 1 2.7 1.0047 -0.80421 0 0 0 0 0 0 0 0 0 0 10.1548 0 0 0 0 A2BDG2 A2BDG2_CANLF Shadow of prion protein sprn Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGSSWRRAPGLGERDPDD 1 12.2 0.97923 0.048313 0 11.6727 0 0 0 0 0 0 0 0 0 0 0 0 0 A2IBY8 MIP_CANLF Lens fiber major intrinsic protein (Aquaporin-0) MIP AQP0 Canis lupus familiaris (Dog) (Canis familiaris) gap junction-mediated intercellular transport [GO:1990349]; lens development in camera-type eye [GO:0002088]; positive regulation of cell adhesion [GO:0045785]; protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; water transport [GO:0006833] apical plasma membrane [GO:0016324]; endoplasmic reticulum [GO:0005783]; gap junction [GO:0005921]; plasma membrane [GO:0005886] calmodulin binding [GO:0005516]; structural constituent of eye lens [GO:0005212]; water channel activity [GO:0015250] ALAFGLALATL;HVLQVALA;SLLRAFCYM 3 9.5 1.0029 -1.7119 0 0 0 0 0 0 0 0 0 0 0 0 9.82896 0 0 A2ICR5 CRBA4_CANLF Beta-crystallin A4 (Beta-A4 crystallin) CRYBA4 Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] KGELSDDYPSL;VGSFHVHSG 2 10.2 1.0036 -1.0415 0 0 0 0 0 0 0 0 0 0 0 9.02042 8.42181 0 0 A2VBC3 A2VBC3_CANLF "Alpha 2,8-sialyltransferase" siat8F Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi apparatus [GO:0005794]; membrane [GO:0016020] sialyltransferase activity [GO:0008373] DTPVSHHYYDNNL;DYLQIIRNIQNCPWKRQEEEY;FHEMPKEYRQILQ;GALLALLASLLLLLLLRL;GALLALLASLLLLLLLRLL;LALLASLLLLLLLRLL;LLALLASLLLLLLLRLLC;PGGALLALLASLLLLLLLRL;YLQIIRNIQNCPWKRQEEEYENFR 9 18.3 0.72781 0.24989 0 7.75181 0 0 0 6.62752 0 0 10.7845 0 0 6.76182 6.75302 0 8.57024 A2VEC8 A2VEC8_CANLF SCO-spondin sspo Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] AACPCTQSSLLWG;ACGCDSGGDCECLCSA;AGAADSTW;CDNQDDCGDGSDEEGCAT;CGDGSDEEGCATPGCGEGQMSCS;CGHNCGEP;CREPWAQTESCNVGPCPGESCKARD;CVYDACGCDSGGDC;CVYDACGCDSGGDCE;CVYDACGCDSGGDCECLC;DACGCDSGGDCEC;DACGCDSGGDCECLC;DACGCDSGGDCECLCS;DCGDGSDEEGCATPGCGEGQMSC;DCQDGSDEDGCVDCR;DDCGDGSDEEGCATPGCGE;DGEEDCADGSDEHGC;DGSDEEGCATPGCGEGQMSCSSGH;DQPPPQGLGD;ESVQTRTT;FSCMAQPCPPPAHCA;GANCVQEPCQLGCG;GAPCEGNS;GCDSGGDC;GMGDSCCYC;GRLYRECQP;GVECTSFCAPGCTCP;GVLCDGMKDCEDGSDEEGCGP;HYEWCVYDACGCDS;LCDGEPHCPDGSDEGP;LEPTAELAAHSWHLSPLCPE;MGDSCCYCAQPGEN;NGQPEDDF;PHRWLCDNQDDCG;PSCGCPPGQ;PTEKGPVTQVPGSEAPH;QEDLVPCTSLYHY;QHIHVGWRKPGFCERLCP;QLVCDGQPD;QNNCGNCTCQDSQWLCGSDSTR;RPDCQDGSDEDGCVDC;RWLCDNQDDCGDGSDEEGCAT;SGLCGDFDGDA;SVQTRTTPSPTQPEATSPGP;TEPCAGCEQQGRVRGVGE;VEGMGDSCCYCAQPG;VLVEGMGDSCCYCAQ;WLCDNQDDCGDGSDEEGCATPG;YEWCVYDACGCD;YEWCVYDACGCDSGGDCE 50 8.6 0.9842 -0.2383 0 0 0 0 0 0 0 0 0 0 0 0 0 8.75235 0 A3RLE1 CRGB_CANLF Gamma-crystallin B (Gamma-B-crystallin) CRYGB Canis lupus familiaris (Dog) (Canis familiaris) lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601] structural constituent of eye lens [GO:0005212] GFQGRCYE;VLDGCWVLY 2 9.7 1.0029 -1.9086 0 0 8.77099 0 0 0 0 0 10.2427 0 0 0 0 0 0 A4GXA4 A4GXA4_CANLF Olfactory receptor OR1P2 OR1P1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TDARLHTPMYFFLASLSCADILFT;TSSFEFLL 2 10.1 1.0028 -0.79562 0 0 0 0 0 0 0 0 0 0 0 0 0 9.36809 0 A4GXA6 A4GXA6_CANLF Olfactory receptor OR52N9 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLAALLIGGFDM;VLMLMALDR 2 6.6 1.0041 -1.0853 0 0 0 0 0 0 0 0 9.1091 0 0 0 0 0 0 A4GXA7 A4GXA7_CANLF Olfactory receptor OR52P3 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] RYGQNASPIV 1 3.2 0.99993 -0.61146 0 0 0 4.34965 0 0 0 0 10.1592 3.62737 0 0 0 9.38362 0 A4Z944 ZBED5_CANLF Zinc finger BED domain-containing protein 5 (Transposon-derived Buster1 transposase-like protein) ZBED5 Canis lupus familiaris (Dog) (Canis familiaris) DNA binding [GO:0003677]; metal ion binding [GO:0046872] AAPHMRIRLSNITP;ILNVYSKLTM;QAVQIINYIKARPHQSRLLKI 3 6.5 0.98796 -0.49622 8.12645 0 0 0 0 0 10.589 0 0 0 0 0 0 0 0 A5H028 A5H028_CANLF Ribonuclease L RNASEL Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; RNA processing [GO:0006396] ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540] EEPSRYLQMKFPDL;HPFFWSWENRYRTLRDVGNESD;IVAGIVGNVKLLKLFLSKGADVN;LHVRCGYTHQ;TALMDAAEH 5 10.8 1.001 -0.64553 0 0 0 0 0 6.74886 0 0 0 0 0 9.78488 0 0 0 A5HKU8 A5HKU8_CANLF Growth hormone secretagogue receptor type 1 (GH-releasing peptide receptor) (Ghrelin receptor) GHSR Canis lupus familiaris (Dog) (Canis familiaris) actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; decidualization [GO:0046697]; G protein-coupled receptor signaling pathway [GO:0007186]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of appetite [GO:0032100]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of synapse assembly [GO:0051963]; response to food [GO:0032094]; response to hormone [GO:0009725] cell surface [GO:0009986]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; growth hormone secretagogue receptor activity [GO:0001616]; growth hormone-releasing hormone receptor activity [GO:0016520] LCSLACSDLLIFLCMPLDLV;PWTFGDLLCKLFQF;VLVVRRFRELRTTT 3 13.8 0.99425 -0.1556 0 0 0 0 5.31499 0 0 0 0 9.40239 0 0 0 9.83072 0 A7E3L1 A7E3L1_CANLF NADPH oxidase 3 (Predicted NADPH oxidase-3) NOX3 Nox3 Canis lupus familiaris (Dog) (Canis familiaris) defense response [GO:0006952]; superoxide anion generation [GO:0042554] NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886] superoxide-generating NAD(P)H oxidase activity [GO:0016175] FWRFQQEVVI;FWYTHHVFIIFFIGLA;HTNTITELLTTIAG;SWDENQAVHIALHWDENTDVV 4 10.8 0.99745 -0.10587 6.16076 4.79364 0 0 9.76313 0 0 0 0 0 0 0 0 0 0 A7E3N6 A7E3N6_CANLF Predicted NADPH oxidase activator 1 noxa1 Canis lupus familiaris (Dog) (Canis familiaris) VEHLEPVDFLGK 1 2.7 0.94507 0.05044 9.91947 0 10.0768 0 0 0 0 0 0 0 0 7.99786 0 0 0 A7VLI5 A7VLI5_CANLF Glycophorin C Gypc GYPC Canis lupus familiaris (Dog) (Canis familiaris) cortical cytoskeleton [GO:0030863]; membrane [GO:0016020] MLRYMYRHKGTY 1 15.8 0.9832 -0.25665 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.9477 A7YH32 CING_CANLF Cingulin CGN Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226] bicellular tight junction [GO:0005923]; myosin complex [GO:0016459] microtubule binding [GO:0008017] DEFRRRILGLEQQL;ELQERLQAE;ENDEFRRR;EPEPAKEALMKDLLEARELL;KDELRATKQELLQLRME;QRDAEQLRRSIQDATQDH 6 6.7 0.98537 -0.43142 0 0 0 7.5716 0 0 0 5.03822 0 0 0 0 0 9.17876 0 A8CX01 A8CX01_CANLF Solute carrier family 23 member 1 SLC23A1 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transmembrane transport [GO:0015882]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886] dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; sodium ion transmembrane transporter activity [GO:0015081] ILALERWKCPP;LVPAKAILALE 2 2.8 0.99695 -0.10918 0 0 0 0 0 0 0 0 7.13802 0 9.26896 0 0 0 0 A8QWU1 A8QWU1_CANLF Protease inhibitor (Secretory leukocyte peptidase inhibitor) ckpi SLPI Canis lupus familiaris (Dog) (Canis familiaris) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]; modulation of process of another organism [GO:0035821]; negative regulation of viral genome replication [GO:0045071]; response to lipopolysaccharide [GO:0032496] extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] DNA binding [GO:0003677]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; serine-type endopeptidase inhibitor activity [GO:0004867] PGRCPVVYGQCLML 1 10.8 0.94424 0.061123 8.53465 0 0 0 0 0 9.48396 0 0 0 0 0 0 0 0 A8VHU1 A8VHU1_CANLF Cardiac inhibitor-2 Canis lupus familiaris (Dog) (Canis familiaris) regulation of signal transduction [GO:0009966] protein phosphatase inhibitor activity [GO:0004864] HDDDEDEEMLETADGESM 1 8.8 0.97055 0.048313 0 0 0 0 0 0 0 0 5.22982 0 0 0 0 0 0 A9JPX7 A9JPX7_CANLF "Crystallin gamma D (Crystallin, gamma D)" crygd CRYGD Canis lupus familiaris (Dog) (Canis familiaris) structural constituent of eye lens [GO:0005212] GCWMLYEQPNYTGGQYFL;YEREDYRGQMMEFTEDCSSLQDRFH 2 24.7 0.99055 -0.29906 0 0 0 0 0 0 0 0 0 0 12.22 0 0 0 0 B0LDS6 B0LDS6_CANLF Ephrin-B2 efnB2 EFNB2 Canis lupus familiaris (Dog) (Canis familiaris) adherens junction organization [GO:0034332]; animal organ morphogenesis [GO:0009887]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; keratinocyte proliferation [GO:0043616]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron projection development [GO:0010977]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell population proliferation [GO:0008284]; regulation of chemotaxis [GO:0050920]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845] glutamatergic synapse [GO:0098978]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685] ephrin receptor binding [GO:0046875] CIIFIVIIITLVVLLLKYRRR;GVCQTRAMKILMK;IIFIVIIITLVVLLLK;IVIIITLVVLLLK;IVIIITLVVLLLKY;QEGGVCQTR;QYEYYKVYMVD;VIIITLVVLLLKYRRRHRKH;YPQIGDKL 9 18 0.98649 -0.3909 8.47909 0 6.27756 0 0 6.62362 0 8.125 14.4133 3.9528 6.72288 10.8123 0 11.5589 10.3229 B1NLQ8 B1NLQ8_CANLF Folliculin FLCN Canis lupus familiaris (Dog) (Canis familiaris) cell-cell junction assembly [GO:0007043]; energy homeostasis [GO:0097009]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; negative regulation of cell proliferation involved in kidney development [GO:1901723]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of pro-B cell differentiation [GO:2000973]; regulation of TOR signaling [GO:0032006]; TOR signaling [GO:0031929] centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819] GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877] HVLMGNQVIWKSRD;LSVFKSLRHMR;MEAALTNQNLS;TKVDSRPKEDTQKL;VLSSEFAVIV;YISHDKETSIKYVSHQHPNHPQ 6 14.2 1.0033 -1.1126 11.0579 11.5345 9.02851 8.11738 0 8.38892 12.7605 12.3765 12.624 0 9.66514 0 15.4143 7.53908 0 B2CW37 B2CW37_CANLF Toll-like receptor 6 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] MNLTHVPEDLP;NLTIVESINKEYIHYPK;VQSEWCHYELYFAHHNLFHEGSNN 3 6.5 0.9896 -0.20273 0 0 0 0 0 0 0 10.4613 0 0 0 0 10.0045 0 0 B2G3R6 B2G3R6_CANLF "Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)" b4GalT4 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139] glycosyltransferase activity [GO:0016757]; metal ion binding [GO:0046872] KDENWDCFIFHDVDL;KKFNRAKLLNVG;KVRLLLLFLLCLTV;MYLLEHLHPF;VGAIQEIPKAQ 5 18 1.0027 -1.162 0 0 0 0 8.09344 0 0 0 0 0 0 10.0128 0 0 0 B2NIZ6 B2NIZ6_CANLF Motilin receptor MTLR MLNR Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] cytosol [GO:0005829]; plasma membrane [GO:0005886] G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562] APFFFLVGVEQ;ARQVASRH;LSRRRARALI 3 7.2 1.0044 -1.0774 0 0 0 0 0 0 0 0 0 10.1167 0 0 10.4073 0 0 B3FRK1 B3FRK1_CANLF CD1a8 protein CD1A8 Canis lupus familiaris (Dog) (Canis familiaris) "antigen processing and presentation, endogenous lipid antigen via MHC class Ib [GO:0048006]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; immune response [GO:0006955]; positive regulation of T cell mediated cytotoxicity [GO:0001916]" external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] endogenous lipid antigen binding [GO:0030883]; exogenous lipid antigen binding [GO:0030884]; lipopeptide binding [GO:0071723] LVWWLWKRW;NHIRDWQLEYPFQIQLV;VLSFQNTSWRP 3 11.2 0.98152 0.035491 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.60785 B3V3S8 B3V3S8_CANLF DC-SIGN protein isoform C CD209 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] carbohydrate binding [GO:0030246] KWELFQESCYFFS 1 5.8 0.94206 0.05962 0 0 0 0 0 0 0 0 0 0 11.6185 0 0 0 0 B4YB22 B4YB22_CANLF Advanced glycosylation end product-specific receptor variant F AGER Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EVKPEDQGTY;LALGILGGLGIAILLIGAIMWRRRQ 2 9 0.97824 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 6.71452 0 B4YY02 B4YY02_CANLF Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) AK1 Canis lupus familiaris (Dog) (Canis familiaris) ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleoside triphosphate biosynthetic process [GO:0009142] cytoplasm [GO:0005737]; cytosol [GO:0005829]; outer dense fiber [GO:0001520] (d)CMP kinase activity [GO:0004127]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550] KAREKLKKTKIIFVV 1 7.1 0.95681 0.053874 0 0 0 0 0 0 0 0 0 0 6.98743 0 0 0 0 B4YY04 B4YY04_CANLF Solute carrier GLUT8 SLC2A8 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] transmembrane transporter activity [GO:0022857] SLGPLSFGFAL;VLFTLSCVPET 2 4.6 0.99571 -0.19003 0 0 0 0 0 11.6274 10.4848 0 0 0 0 0 0 0 0 B5TQW3 B5TQW3_CANLF Melanocortin-3 receptor MC3R Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; regulation of feeding behavior [GO:0060259]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046] EVFLALGIVSLLENILVILAVA;FNTYLVLIMCNSI 2 10.8 0.92257 0.11626 0 0 0 0 7.68236 0 0 10.1104 0 0 0 0 0 0 0 B6EUL3 B6EUL3_CANLF Transporter DAT SLC6A3 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter transport [GO:0006836] axon [GO:0030424]; plasma membrane [GO:0005886] dopamine:sodium symporter activity [GO:0005330]; metal ion binding [GO:0046872] AITPEQERELVDSGEVRQF;GAAGVWKICP 2 4.7 0.99441 -0.56144 0 0 0 0 0 7.09487 0 0 0 0 0 0 7.39772 0 0 B6EY10 B6EY10_CANLF tryptophan 5-monooxygenase (EC 1.14.16.4) TPH1 Canis lupus familiaris (Dog) (Canis familiaris) aromatic amino acid metabolic process [GO:0009072]; bone remodeling [GO:0046849]; mammary gland alveolus development [GO:0060749]; platelet degranulation [GO:0002576]; positive regulation of fat cell differentiation [GO:0045600]; regulation of hemostasis [GO:1900046]; serotonin biosynthetic process [GO:0042427] cytoplasm [GO:0005737] iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510] EEIKTWGTVFQE;HCTQYVRHSSDPLYT;SESFEDAKEKMREFTKT 3 9.9 0.85263 0.16647 0 0 0 3.16361 0 7.94772 8.77475 0 0 0 0 0 0 7.32975 0 B6EY12 B6EY12_CANLF Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) TPH2 Canis lupus familiaris (Dog) (Canis familiaris) aromatic amino acid metabolic process [GO:0009072]; serotonin biosynthetic process [GO:0042427] iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510] KDTRSIENVV;VQLLKSQSTVVMPNPPASIWAEGE 2 6.9 0.99578 -0.57015 0 0 0 0 0 7.42744 0 0 0 0 0 0 0 9.25309 0 B6VH75 SACA3_CANLF Sperm acrosome membrane-associated protein 3 (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) SPACA3 SPRASA Canis lupus familiaris (Dog) (Canis familiaris) fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342] acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; sperm flagellum [GO:0036126] lysozyme activity [GO:0003796] AMKITQQPQGLASWEAWRRHCQGKD;PPGSMLLAFASLLGCLLT 2 26.4 0.98226 -0.24866 0 0 0 0 0 0 12.1165 6.68089 0 0 0 0 0 0 0 B7UAM8 B7UAM8_CANLF BRCA2 BRCA2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair via homologous recombination [GO:0000724]; regulation of DNA-templated transcription [GO:0006355] DIHFQSPESFSFDCDNTS;EIMSPGREADTDP;KKLFSDLENI;LPKSVSYTNACGIFS;NFNTIQKL;NSVPAYSTV;SSKYNDSVSMIQMED;TCNSESDGSDSS;TEKETAKKPTMYTNQSTYSAIENSP;TPEYEETHSSLE 10 9.1 0.95738 0.053875 0 0 0 0 0 0 0 0 0 0 0 0 2.46493 0 0 B7ZDP4 B7ZDP4_CANLF Calcium binding tyrosine phosphorylation regulated (Sperm protein 13) sp13 CABYR Canis lupus familiaris (Dog) (Canis familiaris) sperm capacitation [GO:0048240] calcium ion binding [GO:0005509] MEAEASVLFSDTSL 1 2.8 0.94634 0.077739 8.87157 0 0 0 0 0 0 0 0 0 0 0 0 0 0 B8PZS5 B8PZS5_CANLF HoxB4 Canis lupus familiaris (Dog) (Canis familiaris) NYVDPKFPPCEEYSQSDY 1 50 0.98808 -0.26044 10.3403 0 0 0 0 0 0 0 0 0 0 0 0 0 0 B9TYQ9 B9TYQ9_CANLF NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) ND4 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial membrane [GO:0031966]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] ERIHSRTMVLARGLQT;FMGSLNFLMIQYWIQ;TFTASELIFF 3 8.9 0.99129 -0.2219 0 0 9.62914 0 0 0 0 0 0 0 0 0 0 0 0 B9TYV5 B9TYV5_CANLF Cytochrome c oxidase subunit 2 COX2 Canis lupus familiaris (Dog) (Canis familiaris) electron transport chain [GO:0022900] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] copper ion binding [GO:0005507]; cytochrome-c oxidase activity [GO:0004129] LTVKTMGHQWYWSYEYTDYEDLNF;WTILPAIILVLIALPSL 2 18.1 0.98287 0.046227 0 0 7.55934 0 0 0 0 0 0 0 0 0 0 0 0 B9U054 B9U054_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;VLSLLILNYH 6 15.5 0.98646 -0.45876 0 0 0 10.4893 9.18396 6.31631 0 0 0 8.6367 0 7.83845 9.95248 0 0 B9UM26 B9UM26_CANLF G-protein coupled receptor 81 (Hydroxycarboxylic acid receptor 1) gpr81 HCAR1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of lipid catabolic process [GO:0050995] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FITCYLPS;LDPLVYYFSSPVF;QRPEEMPIPKLCRKSCVRVASSF 3 12.2 1.0034 -1.6411 0 0 8.41032 0 0 7.65213 0 0 0 0 10.137 0 0 0 0 B9VTT2 RHG07_CANLF Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein homolog) (DLC-1) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) DLC1 ARHGAP7 STARD12 Canis lupus familiaris (Dog) (Canis familiaris) actin cytoskeleton organization [GO:0030036]; regulation of Rho protein signal transduction [GO:0035023]; signal transduction [GO:0007165] cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane raft [GO:0045121] GTPase activator activity [GO:0005096]; lipid binding [GO:0008289] CVNYEGQSAYDVADMLKQYFRD;DILYHVKGMQRIVNQWSEKFSDEG;DLLDSKVIEILDSQT;EQHLWDVDLL;PGHISLRRENSSDSP;TQIEAKEACDWLR 6 8.8 0.93982 0.059825 0 0 8.46773 0 0 0 0 0 0 0 0 0 0 0 0 C0IP02 C0IP02_CANLF Advanced glycosylation end product-specific receptor variant B AGER Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EVKPEDQGTY;GSQESRGKQTKR 2 6.5 0.95546 0.05044 0 0 0 0 0 0 0 0 0 0 0 4.29873 0 0 0 C1KG39 C1KG39_CANLF Cytochrome P450 family 1 subfamily B member 1 (Cytochrome P450 family 1 subfamily B polypeptide 1) CYP1B1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; arachidonic acid metabolic process [GO:0019369]; blood vessel endothelial cell migration [GO:0043534]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic cyclic compound [GO:0071407]; collagen fibril organization [GO:0030199]; endothelial cell-cell adhesion [GO:0071603]; estrogen metabolic process [GO:0008210]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to toxic substance [GO:0009636]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739] "estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" DAEFRELLSH;VGRNRLPCLDDQPNLPYTMA;VMSAVCFGC 3 7.2 1.0038 -0.80862 0 9.27293 0 0 0 0 0 6.92113 0 0 0 10.925 0 0 0 C3S7P1 C3S7P1_CANLF Toll-like receptor Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] membrane [GO:0016020] transmembrane signaling receptor activity [GO:0004888] LLRVPALQVLILN;NRLNLCFEERDFVPGREHIA;SIDTIFLGNN;SLELHASFREL;YIRAVTRASF;YQYDAYLCFSGRDFEW 6 9.3 1.0018 -1.3173 0 9.35277 0 4.33871 0 9.28042 0 0 6.83086 0 0 9.54168 0 0 8.79617 C3UZV0 C3UZV0_CANLF Immunity-related GTPase M4 (Interferon-gamma-inducible GTPase IFGGD1 protein) IRGM4 IFGGD1 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; cellular response to interferon-beta [GO:0035458]; innate immune response [GO:0045087] endoplasmic reticulum membrane [GO:0005789] GTP binding [GO:0005525]; GTPase activity [GO:0003924] FLVSSFNPFLHDFPEL;LVSSFNPFLHDFPELRK 2 4.5 0.97468 0.042489 0 0 0 0 0 10.0447 0 10.1106 13.2313 0 0 0 0 0 0 C4MS18 C4MS18_CANLF NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) ND4 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial membrane [GO:0031966]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] ELLTRKKLYISMLILLQLFLI;FMGSLNFLMIQYWIQ;TFTASELIFF 3 10 0.97406 0.047166 10.0509 0 0 0 0 0 0 0 0 0 0 0 8.58331 0 0 C4MSB5 C4MSB5_CANLF Cytochrome c oxidase subunit 1 (EC 7.1.1.9) COX1 Canis lupus familiaris (Dog) (Canis familiaris) oxidative phosphorylation [GO:0006119] mitochondrial inner membrane [GO:0005743]; respiratory chain complex IV [GO:0045277] cytochrome-c oxidase activity [GO:0004129]; heme binding [GO:0020037]; metal ion binding [GO:0046872] FEEPTYVIQK;MGMVWAMMSIGVLGFIVWAHHMFTV;MPRRYSDYPDAYTTWNTVS;NIEWLHGCPP;PPYHTFEEPTYVIQK;TAHAFVMIFF 6 15.2 0.9787 0.035538 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.262 C4MSG2 C4MSG2_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL;VGFITTMAW 6 15.3 0.98422 -0.25446 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13.9102 C4MTR3 C4MTR3_CANLF Cytochrome c oxidase subunit 3 COX3 Canis lupus familiaris (Dog) (Canis familiaris) aerobic electron transport chain [GO:0019646] membrane [GO:0016020]; mitochondrion [GO:0005739] cytochrome-c oxidase activity [GO:0004129] LFIVSEVFFFAGFFWAFYHSSLAP;MYQWWRDVIRESTFQGHHTPI;VIRESTFQGH 3 17.2 0.99157 -0.54822 0 0 0 0 0 8.52532 0 0 0 0 0 0 0 9.38401 0 C4MVT6 C4MVT6_CANLF NADH-ubiquinone oxidoreductase chain 2 (EC 7.1.1.2) ND2 Canis lupus familiaris (Dog) (Canis familiaris) "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] LSYMWNKFP 1 2.6 1.0042 -0.80421 0 0 0 9.57439 0 0 0 0 0 0 0 0 0 0 0 C4MVX4 C4MVX4_CANLF NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) ND1 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] FRYDQLMHLL;GVLFMLAMSSLAVYS;INIISLIIPILLAVAFLTLVE;YMWLIFPAWPLA 4 18.2 1.0032 -1.1203 0 0 0 0 9.13832 0 3.15538 0 0 10.4607 0 0 0 0 0 C4NZX1 C4NZX1_CANLF Tumor necrosis factor superfamily member 13b Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular region [GO:0005576]; membrane [GO:0016020] tumor necrosis factor receptor binding [GO:0005164] QRKKVHVF 1 2.7 0.98934 -0.2632 0 12.3995 0 0 0 0 0 0 0 0 0 0 0 0 0 C5IY80 C5IY80_CANLF Perforin 1 PRF1 Canis lupus familiaris (Dog) (Canis familiaris) killing of cells of another organism [GO:0031640]; leukocyte mediated cytotoxicity [GO:0001909] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; pore-forming activity [GO:0140911] YLKVFFGGQEQRTY 1 2.5 0.9905 -0.26725 0 0 0 0 0 0 0 0 0 0 9.81091 0 0 0 0 D0F1P5 D0F1P5_CANLF Growth/differentiation factor 9 GDF9 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] growth factor activity [GO:0008083] KCLCHLVIKEPEF;VGHRYGSPV 2 4.9 0.99095 -0.26818 0 0 0 0 0 0 0 0 0 0 0 0 9.34405 0 0 D2IJT6 D2IJT6_CANLF Kallikrein F (Kallikrein-related peptidase 9) KLK9 KLNF Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] GVVSGGAEPCSRPRRPAVYTSVCH 1 9.6 0.97399 0.041303 0 0 0 8.6097 0 9.02431 0 0 0 0 0 0 0 0 0 D3DMB4 D3DMB4_CANLF Peptidase inhibitor 3 (Trappin-2) PI3 Canis lupus familiaris (Dog) (Canis familiaris) antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087] cornified envelope [GO:0001533]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867]; structural constituent of skin epidermis [GO:0030280] MRPSSFLVL 1 8.4 0.99327 -0.0091051 0 0 0 0 0 0 0 0 10.0069 0 0 0 0 0 0 D4QA70 D4QA70_CANLF NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) ND5 Canis lupus familiaris (Dog) (Canis familiaris) ATP synthesis coupled electron transport [GO:0042773] mitochondrial inner membrane [GO:0005743]; respirasome [GO:0070469] NADH dehydrogenase (ubiquinone) activity [GO:0008137] IESTNTSNTNAWALL;LFIGWEGVGIMSFLLIGWWYGRTDA;MEFSMWYMHSD;MKLSMSFKLDYFSMIF;NILPKSISYFQMKSSTLISN;PLMEHNQTIQTL 6 16.3 0.9358 0.098428 0 0 0 0 0 0 0 0 6.74886 0 0 0 0 0 0 D5IGD0 D5IGD0_CANLF Thrombospondin 2 THBS2 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; heparin binding [GO:0008201] ANQADHDHDGQGDACDSDDD;DACDSDDDNDG;DGQGDACDSDDDNDG;DSDDDNDG;GDACDDDDDND;GQGDACDSDDD;GTGDACDDDDDNDGVDD;GVSLKVVNSTTGTGEHLRNALW;HFSDPMYKCEC;IDGRWSPWSPWSACTV;SNANQADHDHDGQGDACDSDDDN;TDNNGEGDACSVDI;VGDQCDNNEDIDEDGHQN 13 10.5 0.98018 0.046227 0 0 0 0 0 0 0 5.9635 0 0 0 0 0 0 0 D8KZR7 D8KZR7_CANLF Trace amine-associated receptor 5 TAAR5 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway [GO:0007166]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] trace-amine receptor activity [GO:0001594]; trimethylamine receptor activity [GO:1990081] SYFKVLHTPT;TVLGNLFVVFA;VSYFKVLHTPTNFL 3 7.4 1.0041 -0.81049 0 0 0 8.75752 0 0 10.4743 0 10.1872 0 0 0 0 0 0 E0W6Z3 E0W6Z3_CANLF Insulin-like growth factor II Canis lupus familiaris (Dog) (Canis familiaris) glucose metabolic process [GO:0006006]; ossification [GO:0001503]; positive regulation of cell division [GO:0051781] extracellular space [GO:0005615] growth factor activity [GO:0008083]; hormone activity [GO:0005179] WKQSAQRLRRGLPALLRA 1 9.9 0.97248 0.048313 0 0 0 0 0 0 0 0 0 0 0 2.28004 0 0 0 E0WCW8 E0WCW8_CANLF Potassium inwardly-rectifying channel subfamily J member 16 kcnj16 KCNJ16 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765] monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] DQIILVTPVTIVHEI;LVDTKWRHMFVIF;VYAPFCSAKQLDWKDQQLHNMEK 3 12.2 0.86464 0.16156 0 0 0 5.82965 0 7.25512 0 0 0 0 7.91391 0 0 0 0 E0X4D6 E0X4D6_CANLF LIM homeodomain protein 3 isoform M2-LHX3 LHX3 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" DAGRQRWGPYFRSMK;SPASWLDEVDHG 2 10.2 0.99235 -0.19267 0 0 0 0 0 0 0 0 9.90713 0 0 0 0 0 0 E1B2G6 E1B2G6_CANLF Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) KMO Canis lupus familiaris (Dog) (Canis familiaris) 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; kynurenine metabolic process [GO:0070189]; quinolinate biosynthetic process [GO:0019805]; response to salt stress [GO:0009651]; tryptophan catabolic process [GO:0006569] mitochondrial outer membrane [GO:0005741] FAD binding [GO:0071949]; kynurenine 3-monooxygenase activity [GO:0004502]; NAD(P)H oxidase H2O2-forming activity [GO:0016174] DHAISDLSMYNYIEM;FEDCLVFDEL;HYFRRPWDWLAHFQKTG;YFRRPWDWLAH;YLMKKPRFDYSQQ 5 11.5 1.0022 -0.98706 10.471 0 0 0 0 0 10.2423 0 7.07959 0 0 7.46834 8.53555 0 0 E2DP67 E2DP67_CANLF Collagen type IX alpha 2 COL9A2 Canis lupus familiaris (Dog) (Canis familiaris) collagen type IX trimer [GO:0005594] protein homodimerization activity [GO:0042803] GSDGIDGDKGP;HIVTVMMKMMQ;PRGIMGQKGDQGE;VGQPGPQGRQGPKGE 4 7.3 0.99637 -0.09157 0 11.0518 0 0 0 0 0 0 0 0 0 0 6.19285 9.88622 0 E2DP68 E2DP68_CANLF Collagen type IX alpha 3 COL9A3 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] EAGPPGLP;GDRGPGGA;GVPGREASE;PPGPKGAP 4 4.8 0.99851 -3.277 0 9.22954 0 0 6.07998 8.96653 0 0 0 0 0 0 9.27612 0 0 E2FGH6 E2FGH6_CANLF Kallikrein-related peptidase 6 KLK6 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] secretory granule [GO:0030141] serine-type endopeptidase activity [GO:0004252] FSERIQPLSL;ILMAAAWAEEQNKV;PNTIQCAYIHLVPREECERAYP;VYLGKHNLQQ 4 22.8 1.004 -1.0899 0 10.3016 8.58984 0 6.51737 0 0 9.37626 0 0 0 0 0 0 0 E2FGH7 E2FGH7_CANLF Kallikrein D (Kallikrein-related peptidase 7) KLK7 KLND Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of antibacterial peptide production [GO:0002803]; proteolysis [GO:0006508] cornified envelope [GO:0001533]; epidermal lamellar body [GO:0097209]; extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] NACNGDSG 1 3.1 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.84147 E2QTH3 E2QTH3_CANLF Immunity related GTPase cinema (Interferon-gamma-inducible GTPase IFGGE protein) IFGGE IRGC Canis lupus familiaris (Dog) (Canis familiaris) lipid droplet [GO:0005811]; membrane [GO:0016020]; sperm mitochondrial sheath [GO:0097226] GTP binding [GO:0005525]; hydrolase activity [GO:0016787] LVSPRRCGAV;SEILRQGK;SPRRCGAVETRLAS 3 5 0.99581 -0.11535 8.70946 0 9.04327 0 0 0 0 0 0 0 0 0 0 10.2505 0 E2QU34 E2QU34_CANLF Cationic amino acid transporter 1 (Solute carrier family 7 member 1) SLC7A1 Canis lupus familiaris (Dog) (Canis familiaris) L-arginine import across plasma membrane [GO:0097638]; L-ornithine transmembrane transport [GO:1903352] plasma membrane [GO:0005886] L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064] CLNNDTKQGIFGVGG;LVDLMSIGTLLAYS;PKTGSAYL 3 5.9 0.95353 0.053903 0 0 8.7708 0 0 0 0 0 0 0 0 0 0 0 0 E2QUD0 GATA_CANLF "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1)" QRSL1 Canis lupus familiaris (Dog) (Canis familiaris) glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739] ATP binding [GO:0005524]; glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567] IDVSTEAMYAAT;LAGHDPKDSTTVQDPVKPFTLPSL;VLCTSEVASNMARFDGLE 3 10.3 0.98923 -0.31031 9.84097 11.7238 11.7004 0 0 0 0 0 0 0 0 0 0 0 0 E2QV03 TPPC2_CANLF Trafficking protein particle complex subunit 2 TRAPPC2 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008] EWFVSAFVTAGHM 1 9.3 0.99096 -0.14562 0 0 0 0 0 0 0 0 0 0 0 0 0 11.918 0 E2QWF5 E2QWF5_CANLF peptidylprolyl isomerase (EC 5.2.1.8) FKBP4 Canis lupus familiaris (Dog) (Canis familiaris) chaperone-mediated protein folding [GO:0061077] cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654] heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] VHYTGWLLDGTKFDSSL 1 3.7 0.95315 0.052498 0 0 0 9.96694 0 0 0 0 0 0 0 0 0 0 0 E2QX68 E2QX68_CANLF G protein-coupled receptor 120 gpr120 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone secretion [GO:0046879] plasma membrane [GO:0005886] fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]; taste receptor activity [GO:0008527] CIVRLQRGA 1 2.5 1.0035 -0.80421 0 9.66042 0 0 0 0 0 0 0 0 0 0 0 0 0 E2QXH5 E2QXH5_CANLF Kallikrein-related peptidase 13 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] HSQPWQAALLVQGRL;KDSCEGDS 2 8.3 1.0048 -1.0505 0 0 5.0461 0 0 0 3.90506 0 0 0 0 0 0 0 0 E2QYR1 E2QYR1_CANLF Gap junction protein CXNG GJB1 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922]; cytoplasm [GO:0005737] gap junction channel activity [GO:0005243]; identical protein binding [GO:0042802] EAYPCPNTVDCFV;PSRKGSGFGHRLS 2 9.2 0.9896 -0.51798 0 0 0 0 0 0 0 0 0 0 0 0 10.0404 0 0 E2R0A4 E2R0A4_CANLF Uteroglobin (Secretoglobin family 1A member 1) SCGB1A1 ASRGL1 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] cytoplasm [GO:0005737]; extracellular space [GO:0005615] phospholipase A2 inhibitor activity [GO:0019834] TLALYCSPASAE 1 13.2 0.95384 0.05044 0 0 0 0 0 0 0 10.0037 0 0 0 0 0 0 0 E2R0N4 E2R0N4_CANLF Olfactory receptor DOPRH02 (Olfactory receptor family 10 subfamily K member 2) OR10K2 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] ALVLVIPLLLILV;ELMGHRVCVGL;FVGCAIQMFT;LVIPLLLILVSYIH;VLVIPLLLILV 5 12.1 1.0005 -0.62011 0 5.14425 10.6758 0 0 0 0 9.70838 0 0 0 0 5.37785 0 3.08091 E2R1F3 E2R1F3_CANLF Olfactory receptor OR52B2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVARLACA;TILIVVIITDRNLHEP 2 7.5 0.96302 0.049233 0 0 0 0 0 0 0 0 0 9.46807 0 0 0 0 0 E2R222 PCH2_CANLF Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) TRIP13 PCH2 Canis lupus familiaris (Dog) (Canis familiaris) double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; meiotic recombination checkpoint signaling [GO:0051598]; mitotic spindle assembly checkpoint signaling [GO:0007094]; oocyte maturation [GO:0001556]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] chromosome [GO:0005694]; male germ cell nucleus [GO:0001673]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802] IQDLIDDKDA;SHSLFSKWF;VTIEGFLQALSLA 3 7.4 1.0025 -1.3558 0 7.05961 0 0 0 0 0 0 10.8216 0 0 0 7.84348 0 0 E2R3W5 E2R3W5_CANLF Melanopsin (Opsin-4) OPN4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to light stimulus [GO:0071482]; detection of temperature stimulus involved in thermoception [GO:0050960]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; optokinetic behavior [GO:0007634]; phototransduction [GO:0007602]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; thermotaxis [GO:0043052]; visual perception [GO:0007601] plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020] AAAVWGAAQPAGGRFLCT;IYTFCRTRGLRTPSNMFII;TFCRTRGLRTPSNMF 3 7.7 0.85224 0.15176 0 7.87873 0 0 8.11056 0 0 0 0 0 0 0 8.53718 0 4.17584 E2R603 E2R603_CANLF Gap junction protein CXNL GJA8 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; gap junction-mediated intercellular transport [GO:1990349] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] TVIGRVWL;VGFIVGHYFLYGF;VGKEGEKEEL 3 7.1 1.0025 -0.774 9.76966 0 0 0 0 0 0 10.1981 0 13.5637 0 0 0 0 0 E2RDM9 TSPO2_CANLF Translocator protein 2 TSPO2 Canis lupus familiaris (Dog) (Canis familiaris) 5-aminolevulinic acid import across plasma membrane [GO:0140484]; enucleate erythrocyte differentiation [GO:0043353]; import across plasma membrane [GO:0098739]; intracellular cholesterol transport [GO:0032367]; lipid droplet organization [GO:0034389] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] 5-aminolevulinic acid transmembrane transporter activity [GO:0140485]; cholesterol binding [GO:0015485] LGLYAVQLAVSW;LLLPYLAWLTVTASIAYHLWRD 2 19.8 0.99094 -0.26794 0 11.3658 0 0 0 0 14.1672 0 0 0 0 0 0 0 0 E2RE76 APOA4_CANLF Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4) APOA4 Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; lipoprotein metabolic process [GO:0042157]; phospholipid efflux [GO:0033700] chylomicron [GO:0042627]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] EQSAVPLES;EVSADQVATVV;PVALPKQEQEQSAVPLES;TPVALPKQEQEQSAVPLES 4 7.9 0 4.086 9.32751 12.2362 13.0148 0 0 0 0 12.1836 12.4002 12.1999 11.859 12.2032 0 11.9116 11.6027 E2REN6 E2REN6_CANLF Tetratricopeptide repeat domain 8 TTC8 Canis lupus familiaris (Dog) (Canis familiaris) non-motile cilium assembly [GO:1905515] BBSome [GO:0034464]; ciliary basal body [GO:0036064]; non-motile cilium [GO:0097730] SEMEPLLLAWSYF;TALTLFKQ;VGIGDMNLAH 3 6 1.0032 -1.6561 0 0 9.82922 0 9.84188 4.88289 0 0 0 0 0 0 0 0 0 E2RFE4 E2RFE4_CANLF Adiponectin I (Complement C1q like 2) ADII C1QL2 Canis lupus familiaris (Dog) (Canis familiaris) neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128] cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synaptic cleft [GO:0043083] identical protein binding [GO:0042802] AGGPAGAK;GGKAHGGN 2 5.6 1.002 -1.3703 0 0 0 0 0 0 9.80256 0 12.2242 0 0 0 0 0 0 E2RGQ8 E2RGQ8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) EDEDDYYYSGAYYT;VQWYQQQPGKAPRYLMHVR 2 26.8 0.91261 0.11031 0 0 0 0 0 0 0 0 0 0 0 0 0 8.79562 6.99073 E2RHL4 E2RHL4_CANLF ADP ribosylation factor 6 ARF6 Canis lupus familiaris (Dog) (Canis familiaris) intracellular protein transport [GO:0006886]; protein localization to endosome [GO:0036010]; regulation of dendritic spine development [GO:0060998]; vesicle-mediated transport [GO:0016192] endocytic vesicle [GO:0030139]; exocytic vesicle [GO:0070382]; focal adhesion [GO:0005925]; recycling endosome membrane [GO:0055038]; ruffle [GO:0001726] GTP binding [GO:0005525]; GTPase activity [GO:0003924] TTILYKLKLGQSVTT 1 10.1 0.95655 0.053878 0 0 0 0 0 3.12943 0 0 0 0 0 0 0 0 0 E2RI92 E2RI92_CANLF Pancreas/duodenum homeobox protein 1 (Insulin promoter factor 1) Pdx-1 PDX1 Canis lupus familiaris (Dog) (Canis familiaris) digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell apoptotic process [GO:0097050]; type B pancreatic cell differentiation [GO:0003309]; type B pancreatic cell proliferation [GO:0044342] nuclear speck [GO:0016607]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EVPPLADDSAVAHLHHH 1 6 0.97879 0.046227 0 0 0 0 0 0 0 0 9.87825 0 0 0 0 0 0 E2RKA3 E2RKA3_CANLF Cannabinod receptor (Cannabinoid receptor 2) CNR2 CB2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; leukocyte chemotaxis [GO:0030595]; regulation of metabolic process [GO:0019222] cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886] cannabinoid receptor activity [GO:0004949] PVLALMVYSLTTTL 1 3.9 0.94083 0.10149 0 0 0 0 0 0 0 0 0 0 0 0 9.29211 0 0 E2RKM2 E2RKM2_CANLF FSHD region gene 1 FRG1 Canis lupus familiaris (Dog) (Canis familiaris) muscle organ development [GO:0007517] catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; striated muscle dense body [GO:0055120] actin filament binding [GO:0051015] KGTKAKSKKKKSKEKKRKR;KLVLKGTKAKSKKKKSKEKK;LVLKGTKAKSKKKKSKEKKRKRE;SCFIRCNEAGD;VLKGTKAKSKKKKSKEKKR;VLKGTKAKSKKKKSKEKKRKR 6 13.6 0.67752 0.27594 0 8.0542 0 7.02558 6.32317 0 0 0 9.30044 0 0 0 6.66278 0 0 E2RKN7 FXL15_CANLF F-box/LRR-repeat protein 15 FBXL15 Canis lupus familiaris (Dog) (Canis familiaris) bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005] LLPHILSRVPLRQLLRLQRVSRAF;LSRVPLRQLLRL 2 8 0.93395 0.091743 0 8.79149 0 0 0 0 0 0 0 0 0 0 0 0 4.65082 E2RLA7 E2RLA7_CANLF 2-aminoethanethiol dioxygenase ADO Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456] cysteamine dioxygenase activity [GO:0047800]; iron ion binding [GO:0005506] EAGGGQQP;FWCEGEPYPGPK 2 7.4 0.9875 -0.49776 10.0271 0 10.4511 0 0 0 0 0 0 0 0 0 0 0 0 E2RLE9 E2RLE9_CANLF Sulfotransferase (EC 2.8.2.-) CHST3 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; N-acetylglucosamine metabolic process [GO:0006044]; T cell homeostasis [GO:0043029] Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802] chondroitin 6-sulfotransferase activity [GO:0008459]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; proteoglycan sulfotransferase activity [GO:0050698] ATTRTGSSFVGEFFN;EFFNQQGNIFYLFEPLW;MRSKYALFLA 3 8 1.004 -0.81182 0 5.56047 0 0 8.55252 0 0 0 7.53955 0 0 0 0 0 0 E2RPY3 E2RPY3_CANLF Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) TIMP4 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] HYHLNCGCQITTCYTVP;HYVCMKHVDGTCSW;VLSDGKVFIHLCNY 3 20.1 0.98945 -0.31176 10.611 14.785 10.2731 11.9103 8.60492 0 15.4053 14.7192 0 10.0076 14.4438 14.4314 14.5646 10.7777 11.5651 E2RQ15 RAB25_CANLF Ras-related protein Rab-25 RAB25 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell morphogenesis [GO:0003382]; exocytosis [GO:0006887]; protein transport [GO:0015031] Golgi apparatus [GO:0005794]; pseudopodium membrane [GO:0031260]; recycling endosome [GO:0055037] GTP binding [GO:0005525]; GTPase activity [GO:0003924] QIWDTAGLERY 1 5.2 0.98443 0.035491 0 0 0 0 0 6.62851 0 0 0 0 6.92659 0 0 0 0 E2RRP8 E2RRP8_CANLF Fibroblast growth factor (FGF) FGF8C FGF21 Canis lupus familiaris (Dog) (Canis familiaris) animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell migration [GO:0030334] cytoplasm [GO:0005737]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] VGAARQSPESLLELKALKPGVI 1 10.5 0.99007 -0.26666 0 0 0 0 0 0 0 0 10.0522 0 0 0 0 0 0 E3W284 E3W284_CANLF Anion exchange protein SLC4A3 Canis lupus familiaris (Dog) (Canis familiaris) bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453] plasma membrane [GO:0005886] monoatomic anion transmembrane transporter activity [GO:0008509]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;DYHELGRSI;EDRASVLRTLLLK;EPHWRETARWIKFEEDVEEETERWG;GPLLVFEEAFFKFCRSQD;GVEEEEEDDEEEE;GVEEEEEDDEEEEEG;GVEEEEEDDEEEEEGES;GVEEEEEDDEEEEEGESEA;HPLLPFYPPEGALEAGLE;KPLHMPGGD;RERLCPGSALGSPG;SPLPQVRVPLEEPPLSPDLEE;VEEEEEDDEEEEEGESE;VLRRKKKKK;VLRRKKKKKQL;VLRRKKKKKQLDRR;VLRRKKKKKQLDRRP 18 14.3 1.003 -0.78989 7.00876 0 10.9812 7.12712 0 5.84368 0 10.2609 8.80771 0 0 0 8.6185 10.1455 8.82241 E5D8I2 E5D8I2_CANLF ADAMTS-like 2 protein ADAMTSL2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] extracellular region [GO:0005576] LLNGSYLELSSDRVTN;PCSGSCGQ;RRPMDVYET;VGEKDCTGPPCDRQW;YRRPMDVYETGIEYI 5 6.2 1.0023 -1.7516 0 8.56518 0 10.0429 0 0 0 0 10.9157 0 0 7.05691 0 0 0 E5EVW7 E5EVW7_CANLF TM7SF3 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] LDIDPNIYLEYN;LVSILRPEESMCTWY;QIRRERGRPFFPP;TSLSYITLNVLKRAL 4 10.8 0.80769 0.21777 0 0 0 2.96923 4.98313 0 6.34685 0 0 8.04073 0 0 0 0 0 E5RQH2 E5RQH2_CANLF glutathione transferase (EC 2.5.1.18) H-PGDS HPGDS Canis lupus familiaris (Dog) (Canis familiaris) prostaglandin metabolic process [GO:0006693] cytosol [GO:0005829]; nucleoplasm [GO:0005654] calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; prostaglandin-D synthase activity [GO:0004667]; protein homodimerization activity [GO:0042803] LDIHPRLVTLRKK;LDIHPRLVTLRKKV 2 7 0.91535 0.12044 0 4.78613 0 0 0 0 0 0 0 0 0 0 0 4.13077 0 E9ABV3 E9ABV3_CANLF Sulfotransferase (EC 2.8.2.-) sulfo1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] YHVQNTLIPRF 1 2.7 0.9903 -0.26712 0 0 0 0 0 0 0 0 0 0 0 5.92996 0 0 0 E9ABV4 E9ABV4_CANLF Sulfotransferase (EC 2.8.2.-) sulfo6 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975] Golgi membrane [GO:0000139] sulfotransferase activity [GO:0008146] RLVRSEQEQRNLS 1 3.4 0.93797 0.059718 0 0 0 0 0 0 0 0 0 0 0 0 0 10.4725 0 F1CL90 F1CL90_CANLF Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (Follitropin beta chain) Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179] ATECHCGRCDSDSTDC;DLVYKDAARPS 2 20.9 0.94773 0.084724 0 0 0 2.89165 0 0 0 0 0 0 0 0 10.3232 3.44201 0 F1P9R7 F1P9R7_CANLF Olfactory receptor DTPRH02 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VIMSRWMCL;YTFFAMRLPYCGP 2 7.1 0.98749 -0.49678 0 0 0 0 0 0 0 0 8.98479 0 12.2287 0 0 0 0 F1PCK5 F1PCK5_CANLF Olfactory receptor OR6N1 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] NLLIFLVVRLDP;YSLRNKDIKEAVRRQLR 2 9.2 0.99183 -0.18124 6.24035 0 9.14323 0 0 0 0 0 0 0 0 0 0 0 0 F1PCR0 F1PCR0_CANLF Microsomal glutathione S-transferase 3 MGST3 Canis lupus familiaris (Dog) (Canis familiaris) leukotriene biosynthetic process [GO:0019370]; prostanoid metabolic process [GO:0006692] endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635] glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464] EYPTMYSTDPEN 1 7.9 0.98799 -0.26453 0 0 0 0 0 0 0 10.3324 0 0 0 0 0 0 0 F1PGN1 F1PGN1_CANLF Olfactory receptor OR6B1 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ETWYISVTVPK;VNNSISFTHCMIQLYFFI 2 9.4 0.98536 -0.23737 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.51248 F1PM53 F1PM53_CANLF Tubulin alpha chain TUBA1A TUBA1B Canis lupus familiaris (Dog) (Canis familiaris) microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278] cytoplasm [GO:0005737]; microtubule [GO:0005874] GTP binding [GO:0005525]; hydrolase activity [GO:0016787]; structural constituent of cytoskeleton [GO:0005200] ATIKTKRTIQFVDWCPT;AVFVDLEPTVIDEV;DIERPTYTNL;DVVPKDVNAAIA;GDVVPKDVNAAIA;THTTLEHSDC;TVVPGGDLAKVQ;VFVDLEPTVIDEV;VISAEKAYHEQLSV 9 19.7 0.99327 -0.16222 0 0 0 0 9.86293 0 0 0 0 0 0 0 6.89276 0 0 F1PPU1 F1PPU1_CANLF MAS related GPR family member G (Mas-related G protein-coupled receptor E) MGRE MRGPRG Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] FAVGLWLLAALNAERCLSLLFPTC;VGSALLLCFC 2 11.9 0.98752 -0.22877 0 0 0 0 0 0 0 0 0 0 0 0 0 12.2075 0 F1PPY9 F1PPY9_CANLF Ribonuclease A M1 RAM1 EDDM3B Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] RAFMEQHYLSTSWKFSDYKCNN;WRDPYRNVYIWAQHPFL 2 26.9 0.9893 -0.21907 0 0 0 9.31143 0 0 0 0 10.9399 0 0 0 0 0 0 F1PQS8 F1PQS8_CANLF CKLF like MARVEL transmembrane domain containing 6 (CKLF-like MARVEL transmembrane domain-containing protein 6) CMTM6 Canis lupus familiaris (Dog) (Canis familiaris) endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of protein stability [GO:0031647] early endosome membrane [GO:0031901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038] VGRLRLPGL;VGRLRLPGLAFKVLQLLFSLL 2 11.5 1.0024 -0.75705 0 0 0 0 0 0 0 0 6.45385 0 0 0 0 3.414 0 F1PUC4 F1PUC4_CANLF Olfactory receptor OR51T1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CSILANVYLLLPP;ILILRTVLSIVAPK 2 8.3 0.69176 0.28795 5.27776 8.55048 8.82308 8.59921 8.70543 8.72427 8.7497 9.13317 0 0 0 0 0 0 0 F1PWZ9 F1PWZ9_CANLF NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial respiratory chain complex I assembly [GO:0032981]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; mitochondrial respiratory chain complex I [GO:0005747] TVKPPVARKFI;YYEDNKQFF 2 13.8 1.0025 -0.76872 0 0 0 0 0 0 0 0 0 0 0 7.60095 0 0 8.55777 F1PX08 F1PX08_CANLF Olfactory receptor OR52B6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IPALFSVF 1 2.5 0.99002 -0.26592 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1022 F5ANK3 F5ANK3_CANLF Sonic hedgehog SHH Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; system development [GO:0048731] AAHLLFVAPLNDSAAGE;IHWYSQLLYQIGTW 2 12.6 0.9893 -0.52521 0 0 0 0 0 0 0 0 9.79677 0 0 0 0 0 0 F7VJL5 F7VJL5_CANLF Protamine-2 (Sperm histone P2) (Sperm protamine P2) Prm2 PRM2 Canis lupus familiaris (Dog) (Canis familiaris) chromosome organization [GO:0051276]; nucleus organization [GO:0006997]; spermatid development [GO:0007286] nucleus [GO:0005634] DNA binding [GO:0003677] YRVHRRRRRSCRRRRRRACRHRRHH 1 25 0.97814 0.035538 0 0 0 0 0 0 0 0 6.2541 0 0 0 0 0 0 F8QQ88 F8QQ88_CANLF Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] melanocyte-stimulating hormone receptor activity [GO:0004980] PQDPICGCVFKNFNLFL;SVLSSTLFIAYYN 2 9.5 0.9909 -0.27312 0 10.8894 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJA0 G3FJA0_CANLF Olfactory receptor OR6B6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IIYYTAMIFMYVRPRAIASFNSN;TAPWIQVLLFFLFL;YFLSSLSFL 3 14.6 0.98876 -0.31593 10.5945 0 0 0 0 0 0 0 0 0 0 0 10.2882 0 0 G3FJA8 G3FJA8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FFISQLPFCGPNI;YSLRNREMKFALRQVICGM 2 10.2 0.91683 0.10963 0 7.89512 0 7.08332 0 0 0 0 0 0 0 0 0 0 0 G3FJB0 G3FJB0_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LPLIIPFLFIMGSYTLVLRA 1 6.4 0.97243 0.048206 0 0 0 0 0 0 0 11.8158 10.3574 0 0 0 0 0 0 G3FJB2 G3FJB2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IAPLPPTILISH 1 3.8 0.94716 0.05044 0 9.52939 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJB5 G3FJB5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVPIPGTVLICGTMSSL;VHGDRRLHTPMY;VIFCWVYGFLWFL 3 13.4 0.99177 -0.20701 0 0 0 8.90063 0 0 0 9.97341 0 0 0 0 0 0 0 G3FJB8 G3FJB8_CANLF Olfactory receptor OR6K2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LTLSCCVCG 1 2.8 0.99055 -0.21092 0 0 0 0 0 0 0 0 0 9.61073 0 0 0 0 0 G3FJC0 G3FJC0_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] membrane [GO:0016020]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] ICNPLRYPTI;VGANQTSMVTEFLFS;VGNLTVFF 3 10.4 1.0043 -1.098 0 0 0 0 0 0 0 8.7342 0 5.97968 0 10.5442 0 9.20687 0 G3FJC1 G3FJC1_CANLF Olfactory receptor LOC482217 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISFPACMMQLY;SFPACMMQLY;VSSVTEFQL 3 6.2 1.0043 -1.0872 0 0 7.99169 8.42068 0 0 0 0 0 0 0 0 0 0 0 G3FJC3 G3FJC3_CANLF Olfactory receptor OR6AA6 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YDRYLAICSPLHYSLLMSIHICLWF 1 7.8 0.99108 -0.29762 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.08494 G3FJC4 G3FJC4_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ISFTGCFLQ 1 2.9 1.0038 -0.80421 10.4355 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJC5 G3FJC5_CANLF Olfactory receptor OR1595 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] ETKTISFTACFFQFYF 1 5.1 0.96217 0.049233 0 0 8.18155 0 0 0 0 0 0 0 0 0 0 0 8.57236 G3FJD0 G3FJD0_CANLF Olfactory receptor OR11J6 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LMGNTSIICAVAS 1 4 0.98915 -0.21849 0 10.0268 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJD2 G3FJD2_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLGFPGCWEIQI 1 3.8 0.99065 -0.13786 0 0 0 0 0 0 0 0 12.9385 0 0 0 0 0 0 G3FJE5 G3FJE5_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AGVDCFLLTAMAYDRFL 1 5.4 0.98303 -0.25599 0 9.93889 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJF1 G3FJF1_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVDSVLIVL 1 2.8 1.0039 -0.80421 8.53951 0 8.8364 0 0 0 0 0 0 0 0 0 0 0 0 G3FJF2 G3FJF2_CANLF Olfactory receptor OR52I1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LPGMASIYVAWLGRDTVPLHT;VLAAVDIVMASSVV 2 10.8 0.91649 0.11192 0 0 0 8.83494 0 0 0 8.12164 0 0 0 0 0 0 0 G3FJF6 G3FJF6_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CVHSIYALESSVLLAMAFD;VPPVLNPIIYGARTKEIQS 2 11.9 0.98814 -0.22558 0 0 10.1704 0 0 0 0 0 0 0 0 0 0 0 0 G3FJF9 G3FJF9_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVYRLRYC;NPIIYGVKTKQ;YTTILTSS 3 8.4 1.0022 -1.3676 0 0 8.24008 0 0 0 0 0 0 0 0 0 0 11.4426 0 G3FJG1 G3FJG1_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] QIRLRIFGFFM;VLNPLVYGIN 2 6.6 0.99301 -0.28037 0 0 0 0 0 0 0 0 0 0 0 0 0 9.64544 0 G3FJG2 G3FJG2_CANLF Olfactory receptor OR52E1 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] HMGIARLSCASIRINIIY;VAMAYDRYVAICNPLQ;VIALIILLRPLSFAIPFVLLILR 3 18.2 0.85538 0.15472 0 0 0 0 4.79312 0 0 0 0 0 0 0 5.18789 7.61684 0 G3FJG3 G3FJG3_CANLF Olfactory receptor OR52E2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GVRTKQIYDRVKKLLLQ 1 5.4 0.97663 0.046227 0 5.14429 0 0 0 0 0 0 0 0 0 0 0 0 0 G3FJG4 G3FJG4_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] IIVDVILIASSY;LHQPMFYFLAMLS;LILVTPFVF;VAMAYDRFVAICNPLQ 4 16.1 1.0013 -0.94104 0 0 0 0 0 5.60881 0 11.3691 0 8.22429 0 0 0 0 0 G3XKS2 G3XKS2_CANLF Secreted frizzled-related protein 1 FrzA Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; non-canonical Wnt signaling pathway [GO:0035567] extracellular space [GO:0005615] Wnt-protein binding [GO:0017147] EVKKENGDKKIVPKKKKPLKL;IVPKKKKPLKLGP;KKKKPLKLGPIKKKELKKLV;KKKKPLKLGPIKKKELKKLVL;KKKPLKLGPIKKKELKKLV;NGDKKIVPKKKKPLK;PKKKKPLKLGPIKKKELKKLVL;VPKKKKPLKLGPIKKK;VPKKKKPLKLGPIKKKEL 9 15.6 0.93599 0.073902 4.87917 0 0 0 5.25176 5.71328 0 0 0 0 6.44342 0 3.77146 6.65206 7.97591 G5D534 G5D534_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] VGEYRAVT;YRAVTELGRPDAESWNRQKELLKR 2 30.3 0.97373 0.041303 0 0 0 0 0 0 0 5.61333 0 0 0 0 0 0 0 G5D539 G5D539_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] DIYDREEHVRFDSD 1 15.7 0.93266 0.060769 0 0 0 7.56262 0 0 0 0 0 0 0 0 0 0 0 G8XQP1 G8XQP1_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] VGEFRAVTELGWPSAEYWN 1 21.3 0.95189 0.049853 0 0 0 0 0 0 0 0 0 7.81314 0 0 0 0 0 G8XQP4 G8XQP4_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] FVGRYIHNR;VGEYRAVT 2 19.1 1.0039 -0.80421 0 0 0 9.1134 0 0 0 0 0 0 0 0 0 0 0 G9C8M9 G9C8M9_CANLF Desmocollin 1 DSC1b DSC1 Canis lupus familiaris (Dog) (Canis familiaris) homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] plasma membrane [GO:0005886] calcium ion binding [GO:0005509] LDYNYYTVPII;QGNENGNFKIST;TETSYFAEVEENR;TIFYSISGPG;VLQIGVLNEAQ;YNVSVVAMDTDGRSCTGTL 6 9 1.0032 -1.028 0 0 0 0 0 0 9.02112 0 0 0 5.44152 0 0 0 10.6979 H1ADZ0 H1ADZ0_CANLF CX3C chemokine receptor 1 (Fractalkine receptor) cx3cr1 CX3CR1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; innate immune response [GO:0045087] plasma membrane [GO:0005886] C-X3-C chemokine receptor activity [GO:0016495] ATPQFMFTKQKANECLGD;LETLNLYDF 2 7.6 0.99232 -0.14149 0 0 0 0 11.4088 0 0 7.55113 0 0 0 0 0 0 11.8819 H2DE99 H2DE99_CANLF Syncytin-Car1 CAR1 Canis lupus familiaris (Dog) (Canis familiaris) myoblast fusion [GO:0007520] membrane [GO:0016020] KKLLLLIV;KKLLLLIVTVVTLGLLL 2 3.6 0.98787 -0.46721 0 4.05624 0 0 0 0 0 0 0 0 0 0 0 0 0 H8Y357 H8Y357_CANLF ATP synthase subunit a ATP6 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] VFTLLVSLYLR 1 4.9 0.98057 0.035491 0 0 0 0 0 0 0 0 8.07205 0 0 0 0 0 0 H8Y3X9 H8Y3X9_CANLF ATP synthase subunit a ATP6 Canis lupus familiaris (Dog) (Canis familiaris) proton motive force-driven ATP synthesis [GO:0015986] "mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]" proton transmembrane transporter activity [GO:0015078] HFLPQGTPLPLIPILVVI 1 8 0.97076 0.048313 0 0 0 0 0 0 0 5.35064 0 0 0 0 0 0 0 H8ZYY7 H8ZYY7_CANLF ABC-type antigen peptide transporter (EC 7.4.2.14) TAP1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; peptide transport [GO:0015833] membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; peptide transmembrane transporter activity [GO:1904680] ITHCLSLLEQADQILFLEGGTIC;LFRELRSWRAPRDSDSPRLLHWGSR;RALIRKPRVLILDDV;SLSLTMVTVVTLPLLFLL;SPQVLATQVQTSLA;TSLNLEGLVQFQDVS;WILQDETASAFTRNI 7 17.1 0.9875 -0.47939 9.77223 0 0 0 0 0 0 0 6.13342 0 0 0 0 0 0 H8ZYZ1 H8ZYZ1_CANLF ABC-type antigen peptide transporter (EC 7.4.2.14) TAP2 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885] TAP complex [GO:0042825] ABC-type peptide transporter activity [GO:0015440]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; MHC protein binding [GO:0042287] ALLSSPEAREREQGQEKN;SFLLYQEDL;TVIPYYSG;VGQKQCLAIAR 4 6.9 0.99273 -0.1668 0 0 0 0 0 0 9.80526 0 0 0 0 0 0 0 0 H9GW87 H9GW87_CANLF Transaldolase (EC 2.2.1.2) TALDO1 Canis lupus familiaris (Dog) (Canis familiaris) carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] cytoplasm [GO:0005737] transaldolase activity [GO:0004801] DTGDFHAIDEYKPQ;LDEKAFRWLHNED 2 8 0.93663 0.060924 0 0 7.03727 0 0 0 0 0 0 0 0 0 0 0 0 I0BWP8 I0BWP8_CANLF Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 Canis lupus familiaris (Dog) (Canis familiaris) TQALLADPEPRAASGKGRPCRESL 1 51.1 0.97395 0.041303 0 0 0 0 0 0 0 0 7.81057 0 0 0 0 0 0 I0BWQ7 I0BWQ7_CANLF Potassium voltage-gated channel subfamily A member 6 KCNA6 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] axon terminus [GO:0043679]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] DDSLFPSIPDAFWW;EEDEDEDDSYTF;IFFLFIGVILFS;IMNIIDLVAIFPYFI;QLGDEALAAFREDE;SGGGGQNG;SLAILRVIRLVRVFRI;SLAILRVIRLVRVFRIFKLSRHSK;SLALAAPAEVRGPEG 9 21.6 1.0022 -1.4473 8.84251 0 5.43172 0 0 8.47962 8.80145 0 0 9.73298 0 0 9.5224 9.82003 0 I0CHK2 I0CHK2_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] LVRDIYNREEFVRFDSDVGEFRAVT 1 28.1 0.99207 -0.29496 0 0 0 0 0 11.3196 0 0 0 0 0 0 0 0 0 I7HI71 I7HI71_CANLF "Organic anion/urate transporter, URAT1 (Solute carrier family 22 member 12)" SLC22A12 Canis lupus familiaris (Dog) (Canis familiaris) response to xenobiotic stimulus [GO:0009410]; urate metabolic process [GO:0046415] apical plasma membrane [GO:0016324] PDZ domain binding [GO:0030165]; urate transmembrane transporter activity [GO:0015143] VISVPFFLCFVYSW 1 2.5 0.99364 -0.13258 0 0 0 0 0 0 0 11.1323 0 0 0 0 0 0 0 J7I8M6 J7I8M6_CANLF Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) TIMP-3 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] extracellular matrix [GO:0031012]; extracellular space [GO:0005615] metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020] IVIRAKVVGKKLVK 1 7.4 0.93432 0.060769 0 0 0 0 0 0 5.91078 0 0 0 0 0 0 0 0 J7NP21 J7NP21_CANLF Interferon-gamma-inducible GTPase IFGGB2 protein (Interferon-inducible GTPase 1-like) IFGGB2 Canis lupus familiaris (Dog) (Canis familiaris) autophagosome assembly [GO:0000045]; cellular response to interferon-beta [GO:0035458]; innate immune response [GO:0045087] endoplasmic reticulum membrane [GO:0005789] GTP binding [GO:0005525]; GTPase activity [GO:0003924] FYFVRSKV;KMVFREYDFFIIICATRFK;KYVEKFCS;SLETTLLRELPSH 4 10.9 1.0023 -0.98961 0 7.79805 11.1836 0 0 0 0 0 0 0 0 0 0 9.02912 0 J9NSN5 J9NSN5_CANLF Uncharacterized protein EOLA1 Canis lupus familiaris (Dog) (Canis familiaris) DLAPEELLELET;LLQRLGMTPTQIQA 2 16.5 0.99102 -0.22089 0 0 0 11.4902 0 0 0 0 0 0 0 0 0 0 0 J9NYK7 J9NYK7_CANLF Myeloid associated differentiation marker MYADM Canis lupus familiaris (Dog) (Canis familiaris) establishment of endothelial barrier [GO:0061028]; membrane raft organization [GO:0031579]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of protein kinase C signaling [GO:0090038]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cell migration [GO:0030335]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane raft [GO:0044860] cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ruffle [GO:0001726] NWSMFTWCFCF;PVTVTRTTITT;SLYQHQPALE;VGSPRALTQPLGLLR 4 14.6 0.99324 -0.18742 4.47119 8.52085 8.41223 8.49821 0 0 0 0 0 0 0 8.46054 7.98698 8.0332 10.1308 J9NYQ6 J9NYQ6_CANLF Uncharacterized protein LOC119881384 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" PEVGSLSAGFAT;RKILKYPLLS;SLMEHQRIHTGE;TEGKIYKCNQVEK 4 6.6 1.0038 -1.1036 0 0 0 0 0 0 10.313 0 0 0 0 9.67911 0 0 5.94104 J9NZC3 J9NZC3_CANLF Zinc finger protein 548 LOC119870874 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" EEWGLLDEAQRFL;LGPSIQEAQPCE;YKCSECGKFFRYSSTF 3 7.2 0.98793 -0.49322 0 0 0 8.71466 0 0 0 0 0 0 0 0 9.27782 0 0 J9P0B3 J9P0B3_CANLF Fibroblast growth factor (FGF) FGF4B FGF9 Canis lupus familiaris (Dog) (Canis familiaris) activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle cell proliferation [GO:0060038]; cell-cell signaling [GO:0007267]; chondrocyte differentiation [GO:0002062]; embryonic digestive tract development [GO:0048566]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; male sex determination [GO:0030238]; mesenchymal cell proliferation [GO:0010463]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reproductive process [GO:2000243]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein import into nucleus [GO:0006606]; regulation of cell migration [GO:0030334]; regulation of timing of cell differentiation [GO:0048505]; Sertoli cell proliferation [GO:0060011]; smoothened signaling pathway [GO:0007224]; stem cell proliferation [GO:0072089]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] cytoplasm [GO:0005737]; extracellular space [GO:0005615] fibroblast growth factor receptor binding [GO:0005104]; growth factor activity [GO:0008083] HLEIFPNGTIQGTRKD;SEKLTQEC 2 11.5 1.0024 -1.3562 0 0 0 0 0 0 0 0 10.2817 0 0 0 0 9.57531 0 J9P1G2 J9P1G2_CANLF Adiponectin A (Complement C1q B chain) C1QB ADIA Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] GPKGSPGPP;SPGPPGARGAKGESGDYKATQ 2 10 1.0026 -0.75459 0 0 0 0 0 0 7.50724 0 0 0 0 8.21257 0 0 0 J9P3S7 J9P3S7_CANLF SIX homeobox 1 SIX1 Canis lupus familiaris (Dog) (Canis familiaris) aorta morphogenesis [GO:0035909]; apoptotic process [GO:0006915]; branching involved in ureteric bud morphogenesis [GO:0001658]; cochlea morphogenesis [GO:0090103]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelin receptor signaling pathway [GO:0086100]; epithelial cell differentiation [GO:0030855]; facial nerve morphogenesis [GO:0021610]; fungiform papilla morphogenesis [GO:0061197]; gene expression [GO:0010467]; generation of neurons [GO:0048699]; inner ear development [GO:0048839]; kidney development [GO:0001822]; mesenchymal cell proliferation involved in ureter development [GO:0072198]; mesonephric tubule formation [GO:0072172]; metanephric mesenchyme development [GO:0072075]; middle ear morphogenesis [GO:0042474]; myoblast migration [GO:0051451]; myoblast proliferation [GO:0051450]; myotome development [GO:0061055]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell differentiation [GO:0014033]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; olfactory placode formation [GO:0030910]; organ induction [GO:0001759]; otic vesicle development [GO:0071599]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation involved in ureter development [GO:2000729]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization [GO:0032880]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trigeminal ganglion development [GO:0061551]; ureter smooth muscle cell differentiation [GO:0072193]; ureteric bud development [GO:0001657] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" AKERENTENNNSSSNKQ;YPSPREKRELAEATGLTT 2 12.3 0.98775 -0.23427 0 0 0 7.49217 0 0 0 0 0 0 0 0 0 0 0 J9P710 J9P710_CANLF Hemoglobin subunit zeta (Hemoglobin zeta chain) (Zeta-globin) LOC100855634 Canis lupus familiaris (Dog) (Canis familiaris) hydrogen peroxide catabolic process [GO:0042744] blood microparticle [GO:0072562]; haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] haptoglobin binding [GO:0031720]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; peroxidase activity [GO:0004601] KVGGGGGP 1 4.7 0.98981 -0.26592 0 0 0 0 0 0 12.2029 0 0 0 0 0 0 0 0 J9PA68 J9PA68_CANLF RNA-binding motif protein 11 variant 1 RBM11 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] RNA binding [GO:0003723] AALPQGYFFFQKMQWPAY;PESVSYAIA 2 11.3 0.90219 0.12236 0 0 0 0 11.1727 0 8.26313 0 0 0 0 0 0 0 0 J9PAA7 J9PAA7_CANLF Metallothionein MT3 MT-III Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of axon extension [GO:0030517]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein stabilization [GO:0050821]; removal of superoxide radicals [GO:0019430] cytoplasm [GO:0005737]; inclusion body [GO:0016234]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] cadmium ion binding [GO:0046870]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; protein kinase activator activity [GO:0030295]; zinc ion binding [GO:0008270] CCSCCPAECE 1 14.7 0.99971 -0.61146 0 0 5.26791 0 0 0 0 0 0 0 5.59738 0 5.45566 0 5.70653 J9PBH8 J9PBH8_CANLF Apolipoprotein L3 LOC102156332 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] extracellular region [GO:0005576] lipid binding [GO:0008289] EAKTWSAESMRE;IHGLGLVPVIGG 2 7.3 0.93992 0.10088 0 0 0 0 0 0 5.26547 0 0 0 0 0 7.69766 0 0 M1V4E8 M1V4E8_CANLF Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 Canis lupus familiaris (Dog) (Canis familiaris) integrin-mediated signaling pathway [GO:0007229]; proteolysis [GO:0006508] membrane [GO:0016020] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] DEGEECDPGIMYLNNDTCCSSDCML;DLQASTHIE;DLVTTHELGH;FFSGHVVGEPDS;HLESCACNETDNSC;PEQPPQRL;VHCVDKKLDKQYESL;VTTHELGHNFGAEHDPD;VVPLVLAPR 9 13.5 1.0018 -1.4657 4.94341 0 0 0 0 8.52388 0 0 6.53877 0 0 0 0 12.7825 8.54531 M1VPL3 M1VPL3_CANLF Gamma-secretase subunit APH-1 (APH-1) APH1 Canis lupus familiaris (Dog) (Canis familiaris) Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485] endoplasmic reticulum [GO:0005783]; gamma-secretase complex [GO:0070765] protein-macromolecule adaptor activity [GO:0030674] IHGDSPYYFLTSAFLTA 1 11.4 0.98062 0.046227 0 0 0 0 0 0 0 0 8.31229 0 0 0 0 0 0 M9NCN0 M9NCN0_CANLF POU domain protein Pou3f4 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" CQDHSDEETPT;PVLRDPPDHSDLGSHHCQ;SQPGFTVSG 3 10.6 0.98926 -0.52207 0 0 0 0 0 0 0 0 5.25637 0 0 0 11.0664 0 0 M9PM25 M9PM25_CANLF RALY heterogeneous nuclear ribonucleoprotein (RNA-binding protein Raly short isoform) RALY Canis lupus familiaris (Dog) (Canis familiaris) RNA binding [GO:0003723] ELTQIKSNIDALLGRLEQIAEEQK;VPVKRPRV 2 11.6 1.0033 -1.1159 0 12.3952 4.58009 0 0 0 0 0 0 0 0 11.4759 0 0 0 O02678 PGS1_CANLF Biglycan (Bone/cartilage proteoglycan I) (PG-S1) BGN Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] DLQNNDISE 1 2.4 0.98345 -0.24788 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.04772 O02720 LEP_CANLF Leptin (Obesity factor) LEP OB Canis lupus familiaris (Dog) (Canis familiaris) activation of protein kinase C activity [GO:1990051]; adult feeding behavior [GO:0008343]; bone growth [GO:0098868]; cellular response to leptin stimulus [GO:0044320]; energy reserve metabolic process [GO:0006112]; intestinal absorption [GO:0050892]; leptin-mediated signaling pathway [GO:0033210]; lipid metabolic process [GO:0006629]; negative regulation of appetite [GO:0032099]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of autophagy [GO:0010507]; negative regulation of glucose import [GO:0046325]; phagocytosis [GO:0006909]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of TOR signaling [GO:0032008]; positive regulation of tumor necrosis factor production [GO:0032760]; prostaglandin secretion [GO:0032310]; regulation of angiogenesis [GO:0045765]; regulation of bone remodeling [GO:0046850]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell cycle [GO:0051726]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of endothelial cell proliferation [GO:0001936]; regulation of natural killer cell activation [GO:0032814]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]; regulation of natural killer cell proliferation [GO:0032817]; regulation of nitric-oxide synthase activity [GO:0050999]; response to insulin [GO:0032868]; sexual reproduction [GO:0019953]; T cell differentiation [GO:0030217] extracellular space [GO:0005615] hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428] SLYSTEVVALNR 1 7.2 0.99147 -0.1483 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15.1997 O02813 NPY1R_CANLF Neuropeptide Y receptor type 1 (NPY1-R) NPY1R Canis lupus familiaris (Dog) (Canis familiaris) feeding behavior [GO:0007631]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233] neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; neuropeptide receptor activity [GO:0008188]; pancreatic polypeptide receptor activity [GO:0001602]; peptide YY receptor activity [GO:0001601] FNFCDFRSRDDDYET;KNFQRDLQFFFNFCDFRSRDDDYET;SLPFLIYQVL 3 9.2 0.98942 -0.52205 0 7.41777 0 0 0 0 0 6.23563 7.82572 0 0 0 0 0 0 O18735 ERBB2_CANLF Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene c-ErbB-2) (p185erbB2) (CD antigen CD340) ERBB2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; ERBB signaling pathway [GO:0038127]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886] basal plasma membrane [GO:0009925]; early endosome [GO:0005769]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587] ATP binding [GO:0005524]; RNA polymerase I core binding [GO:0001042]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] CWMIDSECRPRFRE;CYPCAHGH;DPSPLQRYSE;EDDDMGDLVDAEEY;GLLLALLPSG;GTVYKGIWIPDGEN;IAAVVGILLAVVVGLVLGILIKR;IDSECRPRFRE;IIAAVVGILLAVVVGLVLGILIK;KGMSYLEDVRLVHRDLAARN;LAVVVGLVLGILIKRRRQKI;LEDVRLVHRDLA;LLAVVVGLVLGILIKRRRQ;LVLGILIKRRRQKIR;LVLGILIKRRRQKIRK;PESFDGDP;QEVQGYVLIAHS;QPTDCCHEQCAAGCT;RQKIRKYTMRRLLQ;SECRPRFRELVAEF;SIIAAVVGILLAVVVG;SIIAAVVGILLAVVVGLVLGILI;TDFGLARLLDIDETEYHADG;VGILLAVVVGLVLGILIK;VGILLAVVVGLVLGILIKRRR;VGLVLGILIKRRRQKI;VGLVLGILIKRRRQKIRKY;VGLVLGILIKRRRQKIRKYTMRR;VLGILIKRRRQKIRKYTMRRLLQ;VVGILLAVVVGLVLGILIK 30 15.1 1.0011 -2.7185 8.71373 0 7.79259 8.75445 8.94055 8.31384 8.21548 7.99735 7.87903 9.31424 4.99241 9.50056 9.56155 11.8066 11.5431 O18740 K1C9_CANLF "Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)" KRT9 Canis lupus familiaris (Dog) (Canis familiaris) epithelial cell differentiation [GO:0030855]; intermediate filament organization [GO:0045109]; skin development [GO:0043588] cytoskeleton [GO:0005856]; keratin filament [GO:0045095] structural molecule activity [GO:0005198] ENNLRLAVNADING;GGGSGGKG;GGSGGSYGG;GGSGGSYGGGSGSKGGSGR;GKGGSGCS;LEQEIKTY;QEVMSSGQEMESN;SGGGRGGGCEEGSGSG;SGGSYGGG;SSGGGGGS;SYGGGSGSGGGSSCSYGGGS 11 27.5 0.99712 -3.5811 0 10.4509 0 14.3161 14.3034 14.4221 0 8.42051 13.5649 9.49001 0 0 12.5652 13.6852 12.8916 O18806 FA8_CANLF Coagulation factor VIII (Procoagulant component) F8 Canis lupus familiaris (Dog) (Canis familiaris) "acute-phase response [GO:0006953]; blood coagulation, intrinsic pathway [GO:0007597]" extracellular space [GO:0005615] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] AAATEKTGSLGPPNMSVHF;CCFLCLLPFSLSATRKYYLGAVE;EDPTLKENFRFHAINGY;KTREAIQYESGILGPL;KYKWTVTVE;LSVFFSGYTFKHKMV;MPLGMESKAISDAQITA;NEDKDYDDGLYDSDMDVVS;NQMVERFP;RTSGVQEGSHFLQ;SDVDLEKDVHSGL;SLTQAEAQ 12 7.6 0.9764 0.046444 0 0 0 0 0 0 0 0 9.95871 0 0 0 0 0 0 O18873 ALL1_CANLF Major allergen Can f 1 (Allergen Dog 1) (allergen Can f 1) Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] small molecule binding [GO:0036094] DTVAVSGKWYLKAMTAD;YLKAMTADQEVPEKP 2 13.8 0.98985 -0.52777 0 0 0 0 0 0 10.6104 0 0 0 0 0 0 0 0 O18874 ALL2_CANLF Minor allergen Can f 2 (Allergen Dog 2) (allergen Can f 2) Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] small molecule binding [GO:0036094] LHGDILIPQDGQ 1 6.7 0.94783 0.05044 0 0 0 0 0 0 0 0 9.08807 0 0 0 0 0 0 O18914 OPSR_CANLF Long-wave-sensitive opsin 1 (Red cone photoreceptor pigment) (Red-sensitive opsin) OPN1LW RCP Canis lupus familiaris (Dog) (Canis familiaris) cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601] photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] G protein-coupled photoreceptor activity [GO:0008020] AEKEVTRMVVVMVLAYCLC;GIAFSWIWAAVWTAP 2 9.3 0.93929 0.10379 0 0 0 0 9.13235 0 0 0 7.62103 0 0 0 0 0 0 O18987 O18987_CANLF Vascular anastomotic upregulated protein Canis lupus familiaris (Dog) (Canis familiaris) DEGVRNDFDTLFS;LDGYCEEF;VLINIPILDEGVRNDFDTL 3 24.6 1.0018 -0.9951 0 6.98037 0 0 0 0 0 7.7896 0 0 0 0 0 7.78143 0 O19179 GUC2D_CANLF "Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (Guanylate cyclase E) (GC-E) (Rod outer segment membrane guanylate cyclase) (ROS-GC)" GUCY2D GUC2D Canis lupus familiaris (Dog) (Canis familiaris) cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; visual perception [GO:0007601] endoplasmic reticulum membrane [GO:0005789]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672] FLHPHGGS;LLLLLLLL;LLLLLLLLP;LLLLLLLP;LPQRNGQRHAAEIANM;RLLLLLLL;RLLLLLLLL;VDLLNDLYTLFDA;VQDGPRVRAVI;VSMDQAPVECIQLMKQ 10 6.7 0.9921 -0.54983 0 0 0 0 9.77035 0 0 0 13.4538 0 2.99874 0 0 0 0 O46550 CAV2_CANLF Caveolin-2 CAV2 CAV-2 Canis lupus familiaris (Dog) (Canis familiaris) caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; endoplasmic reticulum organization [GO:0007029]; insulin receptor signaling pathway [GO:0008286]; mitochondrion organization [GO:0007005]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; regulation of cytosolic calcium ion concentration [GO:0051480]; skeletal muscle fiber development [GO:0048741]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] caveola [GO:0005901]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane raft [GO:0044853] D1 dopamine receptor binding [GO:0031748]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901] TIWKSVTDAV 1 6.2 0.99906 -0.61146 0 0 0 0 0 0 0 0 0 6.03646 0 0 0 0 0 O46605 O46605_CANLF Multidrug resistance p-glycoprotein MDR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] VLSSEYTIG;VLSSEYTIGQVLTVFFSV 2 1.4 0.99444 -0.019081 0 0 0 13.6572 10.0066 12.9911 13.125 14.6436 0 0 0 0 0 0 10.8214 O46634 CD166_CANLF CD166 antigen (Activated leukocyte cell adhesion molecule) (SB-10 antigen) (CD antigen CD166) ALCAM Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; axon extension involved in axon guidance [GO:0048846]; cell adhesion [GO:0007155]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron projection extension [GO:1990138]; retinal ganglion cell axon guidance [GO:0031290] axon [GO:0030424]; dendrite [GO:0030425]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886] PSGEVTKQIGDALPVSC;VGIVLRLLHGALV 2 5.8 0.93192 0.10579 0 0 0 0 4.06807 0 0 0 0 0 0 0 0 0 2.1122 O46635 5HT2A_CANLF 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (5-hydroxytryptamine receptor) (Serotonin receptor 2A) HTR2A 5-HTR2A Canis lupus familiaris (Dog) (Canis familiaris) "chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; intracellular calcium ion homeostasis [GO:0006874]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; release of sequestered calcium ion into cytosol [GO:0051209]; response to xenobiotic stimulus [GO:0009410]; serotonin receptor signaling pathway [GO:0007210]" axon [GO:0030424]; caveola [GO:0005901]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; presynapse [GO:0098793] "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]" FLFVVMWCPFF;FSFLPQSSL 2 4.3 0.98952 -0.30634 0 0 0 0 0 0 0 0 0 0 0 0 0 9.84842 9.19094 O46669 SCNAA_CANLF Sodium channel protein type 10 subunit alpha (NaNG) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) SCN10A Canis lupus familiaris (Dog) (Canis familiaris) membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of heart rate [GO:0002027]; sodium ion transmembrane transport [GO:0035725] axon [GO:0030424]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006] DEAFVEFMV;IGRILRLIRAAKGIRTL;LPTGELAPGGIEVSAF;LVMFIYSIFGMA;PAEGGDDSSSSGGST;PGSGHGEDGH;QETLEMPRKEQEV;TLFRVIRLARIGRILRLIR;VIRLARIGRILRLIRA;VLRALKTVSVIPGLKVIVGALI;WVAYGFKKYFTNAWCWLDFLIVNI 11 7.5 0.92008 0.1137 0 0 0 0 0 8.76298 0 0 0 6.30204 0 0 0 0 0 O62658 O62658_CANLF RNA-directed DNA polymerase (EC 2.7.7.49) Canis lupus familiaris (Dog) (Canis familiaris) catalytic activity [GO:0003824] ANKLGNLEEMDAF;MDAFLESHKL;MNEKGEITTNT;PDSIQILEENTGH;PSICCLQETHFRQ 5 4.4 0.93934 0.064066 0 0 0 0 0 0 0 9.045 9.02423 0 0 0 0 0 0 O62671 CP241_CANLF Cytochrome P450 2C41 (EC 1.14.14.1) (CYPIIC41) CYP2C41 Canis lupus familiaris (Dog) (Canis familiaris) epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] "arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" VEELRKTNALPCDP 1 2.9 0.99654 -0.091109 0 0 9.64091 0 0 0 0 0 0 0 0 0 0 0 0 O77559 ADML_CANLF Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] ADM Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; positive regulation of heart rate [GO:0010460]; regulation of systemic arterial blood pressure [GO:0003073] extracellular space [GO:0005615] adrenomedullin receptor binding [GO:0031700]; hormone activity [GO:0005179] KWAVSRGKRELR 1 6.4 0.98418 -0.24021 0 0 0 0 0 0 0 12.3907 0 0 0 0 0 0 0 O77560 PHOS_CANLF Phosducin (PHD) (33 kDa phototransducing protein) PDC Canis lupus familiaris (Dog) (Canis familiaris) regulation of G protein-coupled receptor signaling pathway [GO:0008277]; visual perception [GO:0007601] cytosol [GO:0005829]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] GVKGCDALNSSFTC;SIQEYELIHRDK;SRKMSIQEYELIHRDKED 3 13.1 0.85455 0.15965 0 0 5.56952 0 0 0 0 0 0 0 0 0 0 7.26782 7.54921 O77645 STP2_CANLF Nuclear transition protein 2 (TP-2) (TP2) TNP2 Canis lupus familiaris (Dog) (Canis familiaris) acrosome reaction [GO:0007340]; penetration of zona pellucida [GO:0007341]; positive regulation of protein processing [GO:0010954]; sperm DNA condensation [GO:0035092]; spermatogenesis [GO:0007283] nucleolus [GO:0005730]; nucleosome [GO:0000786] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] HTCSQCTCSSHCQTCSQS 1 14 0.99123 -0.27456 0 0 0 0 0 0 0 0 0 0 0 10.9028 0 0 0 O77808 V2R_CANLF Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) AVPR2 V2R Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of gene expression [GO:0010628]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992] plasma membrane [GO:0005886] peptide binding [GO:0042277]; vasopressin receptor activity [GO:0005000] IYAFFSSSV 1 2.4 0.98848 -0.21799 0 0 0 0 0 0 11.7705 0 0 0 0 0 0 0 0 O78116 O78116_CANLF MHC class II DLA DQ beta chain DLA-DQB Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002504] MHC class II protein complex [GO:0042613] DVGEFRAVTELGRPDAEYWNRQKD;LIFLGLGLIIRHRSQKG 2 15.2 0.94937 0.056242 7.44642 0 7.98692 0 0 0 0 0 0 0 0 0 0 0 0 O97556 GDIB_CANLF Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] cytoplasm [GO:0005737]; membrane [GO:0016020] GTPase activator activity [GO:0005096]; Rab GDP-dissociation inhibitor activity [GO:0005093] IGEVYKKFDL;NSCQIIIPQ 2 4.3 0.99884 -0.61146 0 7.47298 0 0 0 0 0 0 0 0 0 0 0 0 0 O97571 CXCR2_CANLF C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (CD antigen CD182) CXCR2 IL8RB Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; immune response [GO:0006955]; neutrophil chemotaxis [GO:0030593]; positive regulation of cytosolic calcium ion concentration [GO:0007204] external side of plasma membrane [GO:0009897] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine receptor activity [GO:0016494]; interleukin-8 binding [GO:0019959] NSLVIMVVLYS 1 3.1 0.9848 0.035491 0 0 0 0 0 0 0 0 0 0 0 9.55467 0 0 0 O97758 ZO1_CANLF Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Canis lupus familiaris (Dog) (Canis familiaris) ameloblast differentiation [GO:0036305]; bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cellular response to calcium ion [GO:0071277]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of blood-brain barrier permeability [GO:1905605]; protein localization to cell-cell junction [GO:0150105] bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; tight junction [GO:0070160] calmodulin binding [GO:0005516]; cell adhesion molecule binding [GO:0050839] AAVVPPLI;AVSTPVKHADDHTHKTVEEVVVERN;EQPTYRYDS;FSRNYDHRLRYEERIPTYEEQWSY;GGDRADFW;KPSTHIPAG;LSSIETGVSIIIPQGAIPE;PDPEPVSENEDSYDEE;PKTLAKAH;PSDHSRHSPQQ;QHPRDLDSRQHPEESSERGSYPRF;SSKAGHYEPLHGAAV;VSENEDSYDEEVHDP;VVFLNPDSKQGVKTMRMRLCPES 14 11.3 0.97391 0.041303 0 0 0 0 0 8.66708 0 0 0 0 0 0 0 0 0 O97769 O97769_CANLF Titin isoform N2B TTN Canis lupus familiaris (Dog) (Canis familiaris) PEPVKVPEIKPAIPLP;TLTVTVPE 2 13.6 1.0043 -1.1044 0 0 7.24422 0 0 0 0 0 0 0 0 0 0 0 0 O98123 O98123_CANLF MHC class I DLA-88 dla88 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of peptide antigen via MHC class I [GO:0002474] lumenal side of endoplasmic reticulum membrane [GO:0098553]; MHC class I protein complex [GO:0042612]; phagocytic vesicle membrane [GO:0030670] DTRSWTAADTAAQITR 1 17.6 0.94872 0.055397 0 0 0 0 0 0 0 0 0 0 6.07805 0 0 0 0 P01321 INS_CANLF Insulin [Cleaved into: Insulin B chain; Insulin A chain] INS Canis lupus familiaris (Dog) (Canis familiaris) cellular response to oxygen-containing compound [GO:1901701]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; positive regulation of protein secretion [GO:0050714] extracellular space [GO:0005615] hormone activity [GO:0005179] VEDLQVRDVELAGA 1 12.7 0.99039 -0.20181 0 10.1191 0 0 0 0 0 0 0 0 0 0 0 0 0 P01785 HV02_CANLF Ig heavy chain V region MOO Canis lupus familiaris (Dog) (Canis familiaris) immunoglobulin mediated immune response [GO:0016064] immunoglobulin complex [GO:0019814] antigen binding [GO:0003823] ADISSSGQTYYAD;ESGGDLVKPG;ESGGDLVKPGG;EVKLVESG;EVKLVESGG;EVKLVESGGD;EVKLVESGGDL;EVKLVESGGDLVKPG;EVKLVESGGDLVKPGG;EVKLVESGGDLVKPGGSLRLS;LVESGGDLVK;LVESGGDLVKPG;LVESGGDLVKPGG;SGGDLVKPG;SGGDLVKPGG;VESGGDLVKPG;VESGGDLVKPGG 17 29.1 0.99693 -0.10187 0 0 9.7445 0 0 0 0 0 0 0 9.24348 0 0 0 0 P02648 APOA1_CANLF Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I] APOA1 Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; lipoprotein metabolic process [GO:0042157]; peptidyl-methionine modification [GO:0018206]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phospholipid efflux [GO:1902995]; protein oxidation [GO:0018158]; protein stabilization [GO:0050821] chylomicron [GO:0042627]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]; very-low-density lipoprotein particle [GO:0034361] cholesterol transfer activity [GO:0120020]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803] AAIDEATKKLN;AAIDEATKKLNA;AAIDEATKKLNAQ;AEYHARASEQL;AEYHARASEQLSAL;AEYHARASEQLSALG;AIDEATKKLN;AIDEATKKLNA;AIDEATKKLNAQ;ASEQLSALGEKARPA;ASEQLSALGEKARPALE;ASEQLSALGEKARPALEDL;ASLAEYHA;ASLAEYHARASEQL;ASLAEYHARASEQLSALG;DEATKKLN;DEATKKLNAQ;DEPQSPWDRVK;DEPQSPWDRVKD;DEPQSPWDRVKDL;DEPQSPWDRVKDLA;DEPQSPWDRVKDLAT;DEPQSPWDRVKDLATV;DEPQSPWDRVKDLATVY;DNLEKETEVL;DRVKDLAT;DRVKDLATV;DRVKDLATVY;DRVKDLATVYVDAVKD;DRVKDLATVYVDAVKDSG;DSLSSTVTKL;DSLSSTVTKLREQIG;DSLSSTVTKLREQIGPVTQEF;EALKEGGGASL;EASALGKQLNL;EEVELYRQ;EGGGASLAEYH;EGGGASLAEYHA;ESFKVSLLAAIDEATKKLNAQ;FKVSLLAAIDEATKKLNA;FKVSLLAAIDEATKKLNAQ;GASLAEYHA;GASLAEYHARASE;GASLAEYHARASEQL;GGASLAEYH;GGASLAEYHA;GGASLAEYHARA;GGASLAEYHARASEQL;GGASLAEYHARASEQLSAL;GGASLAEYHARASEQLSALG;GGGASLAEYHA;GGGASLAEYHARASEQL;HARASEQLSALGEKA;IDEATKKLN;IDEATKKLNAQ;KQLNLKLLDN;KVAPLGSEL;KVSLLAAIDEATKKLNAQ;LAAIDEATKKLNA;LAAIDEATKKLNAQ;LKEGGGASL;LLAAIDEATKKLNAQ;LNLKLLDN;LRQGLLPVLES;NLEKETEVL;PLGSELREG;PQSPWDRVKDLAT;PVLESFKVSLL;QLNLKLLDN;RAQLAPYSDD;REQIGPVTQEF;RQEMSKDLEEV;RQKVAPLG;SALGEKARPAL;SALGEKARPALED;SALGEKARPALEDLRQG;SALGEKARPALEDLRQGLLPVLES;SFKVSLLAAIDEATKKLNAQ;SLLAAIDEATKKLNAQ;SLSSTVTKL;TVYVDAVKDSG;VSLLAAIDEATKKLNAQ;VYVDAVKDS;VYVDAVKDSG;VYVDAVKDSGRD;VYVDAVKDSGRDYVAQ;VYVDAVKDSGRDYVAQF;YRQKVAPLG;YRQKVAPLGSEL 89 69.5 0.21008 0.74653 0 0 0 0 0 0 0 10.2886 10.4332 0 0 0 0 0 0 P02727 GLPA_CANLF Glycophorin-A (CD antigen CD235a) GYPA Canis lupus familiaris (Dog) (Canis familiaris) ankyrin-1 complex [GO:0170014]; plasma membrane [GO:0005886] ISTEDPSF;VHIFSEPVIIGIIYA 2 17.8 1.0048 -1.0505 4.05337 7.85587 0 0 0 0 0 0 0 0 0 0 0 0 0 P06871 TRY1_CANLF Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-1) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) PRSS1 TRP1 TRY1 TRYP1 Canis lupus familiaris (Dog) (Canis familiaris) digestion [GO:0007586]; proteolysis [GO:0006508] extracellular space [GO:0005615] metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252] QVSLNSGYHFC 1 4.5 0.98183 0.035491 0 0 0 0 0 0 0 0 7.07767 0 0 0 0 0 0 P10463 CAYP1_CANLF Calcyphosin (Calcyphosine) (Protein 5) (Thyroid protein p24) (TPP) CAPS Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] calcium ion binding [GO:0005509] AELGLVLDTAEAEG 1 7.4 0.9438 0.061118 0 0 9.26931 0 0 0 0 0 0 0 0 0 0 0 0 P10673 NEUT_CANLF Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); NT-tail; Tail peptide] NTS Canis lupus familiaris (Dog) (Canis familiaris) blood vessel diameter maintenance [GO:0097746]; negative regulation of gene expression [GO:0010629]; neuropeptide signaling pathway [GO:0007218]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897] axon terminus [GO:0043679]; extracellular region [GO:0005576]; transport vesicle [GO:0030133] neuropeptide hormone activity [GO:0005184]; neuropeptide receptor binding [GO:0071855] HTSKISKASVSSWKMTLLNVCS 1 12.9 0.97356 0.048172 0 0 0 7.48422 0 0 0 0 0 0 0 0 0 0 0 P11614 5HT1D_CANLF 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) HTR1D RDC4 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of behavior [GO:0050795]; regulation of locomotion [GO:0040012]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594] GPPLFFNHVQVKLAEGVLERKRI;LITGSAGSSLCSLSPSLQ;SLINPIIYTVFNE 3 14.3 0.86789 0.18617 0 0 0 0 0 0 9.5254 0 10.2115 0 0 0 0 0 0 P11616 AA1R_CANLF Adenosine receptor A1 ADORA1 RDC7 Canis lupus familiaris (Dog) (Canis familiaris) excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor signaling pathway [GO:0007186]; leukocyte migration [GO:0050900]; long-term synaptic depression [GO:0060292]; mucus secretion [GO:0070254]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of mucus secretion [GO:0070256]; regulation of glomerular filtration [GO:0003093]; regulation of sensory perception of pain [GO:0051930]; response to purine-containing compound [GO:0014074] dendrite [GO:0030425]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled adenosine receptor activity [GO:0001609] LFGWNRLGEAQRAWAANGS;VIKCEFEKVI 2 8.9 0.98535 -0.44665 0 0 0 0 13.098 0 0 0 0 0 0 0 9.45267 0 0 P11617 AA2AR_CANLF Adenosine receptor A2a ADORA2A RDC8 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic signaling pathway [GO:0097190]; eating behavior [GO:0042755]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of inflammatory response [GO:0050728]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; response to amphetamine [GO:0001975]; response to purine-containing compound [GO:0014074]; synaptic transmission, dopaminergic [GO:0001963]" plasma membrane [GO:0005886]; postsynapse [GO:0098794] calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] GVWANGSAPHPERRPN 1 3.9 0.98334 -0.24801 0 9.29119 0 0 0 0 0 0 0 0 0 0 0 0 0 P15944 TRYT_CANLF Tryptase (EC 3.4.21.59) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular space [GO:0005615] serine-type endopeptidase activity [GO:0004252] ALQRVGIVGGREAPG;PCWVTGWGDVHSGT;TGWGDVHSG;VSPAPGQAL 4 13.1 1.0026 -1.7756 0 0 0 0 0 0 0 0 0 0 12.2073 0 7.23716 9.15954 0 P17124 HRH2_CANLF Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 Canis lupus familiaris (Dog) (Canis familiaris) "chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594] IARDQAKRIHHM;ISITLSFLSIH;LRYPVLITPVRVAVSLVLIW 3 12 0.98947 -0.20279 0 0 0 0 0 0 8.32436 0 0 0 0 0 8.37469 0 0 P18066 RAB5A_CANLF Ras-related protein Rab-5A (EC 3.6.5.2) RAB5A Canis lupus familiaris (Dog) (Canis familiaris) amyloid-beta clearance by transcytosis [GO:0150093]; canonical Wnt signaling pathway [GO:0060070]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; modulation by host of viral process [GO:0044788]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; receptor internalization [GO:0031623]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465] actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early phagosome [GO:0032009]; endomembrane system [GO:0012505]; exocytic vesicle [GO:0070382]; lipid droplet [GO:0005811]; melanosome [GO:0042470]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; sorting endosome [GO:0097443]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] DLANKRAVDFQEAQSYA 1 7.9 0.97946 0.046227 0 0 0 0 0 0 7.74052 0 0 0 0 0 0 0 0 P18174 INVO_CANLF Involucrin IVL Canis lupus familiaris (Dog) (Canis familiaris) keratinization [GO:0031424] cytoplasm [GO:0005737] EQKLHLEQCLEQHQ;QEQQQGKEQCE;QEQQQKQQESQEQKL 3 12.6 0.9947 -0.15511 0 0 9.24776 0 0 0 0 0 0 7.69063 8.10444 0 8.85116 8.76487 8.94851 P18649 APOE_CANLF Apolipoprotein E (Apo-E) APOE Canis lupus familiaris (Dog) (Canis familiaris) acylglycerol homeostasis [GO:0055090]; cholesterol efflux [GO:0033344]; cholesterol metabolic process [GO:0008203]; chylomicron remnant clearance [GO:0034382]; high-density lipoprotein particle assembly [GO:0034380]; intermediate-density lipoprotein particle clearance [GO:0071831]; lipoprotein biosynthetic process [GO:0042158]; melanosome organization [GO:0032438]; negative regulation of amyloid fibril formation [GO:1905907]; phospholipid efflux [GO:0033700]; positive regulation of amyloid-beta clearance [GO:1900223]; triglyceride-rich lipoprotein particle clearance [GO:0071830]; very-low-density lipoprotein particle clearance [GO:0034447] "chylomicron [GO:0042627]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; high-density lipoprotein particle [GO:0034364]; intermediate-density lipoprotein particle [GO:0034363]; low-density lipoprotein particle [GO:0034362]; multivesicular body, internal vesicle [GO:0097487]; very-low-density lipoprotein particle [GO:0034361]" amyloid-beta binding [GO:0001540]; cholesterol transfer activity [GO:0120020]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228]; phospholipid binding [GO:0005543] DGLVEKVQAAVATIPTSKPVEEP;DVQPEPEL;DVQPEPELE;DVQPEPELER;DVQPEPELEREL;DVQPEPELERELE;DVQPEPELERELEPKVQQELEPEAG;ERELEPKVQQELEPEAG;PLLEQARE 9 17.3 0 3.019 13.1111 13.7144 13.6968 0 0 0 10.2864 10.0935 9.85254 13.2341 13.0842 13.4961 10.3052 12.3776 13.2735 P18842 LSHB_CANLF Lutropin subunit beta (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) (Lutropin beta chain) LHB Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] cytoplasm [GO:0005737]; extracellular space [GO:0005615] hormone activity [GO:0005179] GPCRLSNSDCGGPRA 1 10.9 0.95344 0.053888 0 0 0 8.54512 0 0 0 0 0 0 0 0 0 0 0 P19006 HPT_CANLF Haptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] HP Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; defense response to bacterium [GO:0042742]; immune system process [GO:0002376] extracellular space [GO:0005615] antioxidant activity [GO:0016209]; hemoglobin binding [GO:0030492]; serine-type endopeptidase activity [GO:0004252] AWVQETIAGN;DGVYTLNSEKH;DYAEVGRIGYVSG;GGSVDAKGSF;GGSVDAKGSFP;GKPKNPVDQV;GKPKNPVDQVQ;GKPKNPVDQVQRIMGGS;GSVDAKGSF;GSVDAKGSFP;GVYTLNSEKH;GVYVKVPSVLA;HKDDAKANDIAPTL;HYEGSTVPEKKSP;IKLKQKVPIDE;IMGGSVDA;IMGGSVDAK;IMGGSVDAKG;IMGGSVDAKGS;IMGGSVDAKGSF;IMGGSVDAKGSFP;IMGGSVDAKGSFPW;IMGGSVDAKGSFPWQ;IMGGSVDAKGSFPWQA;IMGGSVDAKGSFPWQAK;IMGGSVDAKGSFPWQAKM;KNPVDQVQ;KPKNPVDQV;KPKNPVDQVQ;LLTTAKNLF;LLTTAKNLFL;LLTTAKNLFLG;LLTTAKNLFLGHKDD;LLTTAKNLFLGHKDDA;NPVDQVQR;PDYSKVDIGL;PKNPVDQVQ;PKPPVIENG;STVPEKKSPKSPVG;SVDAKGSF;SVDAKGSFP;TEGDGVYTLNSEKH;TEVSLPKPPVIE;TEVSLPKPPVIENG;TEVSLPKPPVIENGY;VEHMIRYQ;VQPILNEH;VYTLNSEKH;VYVKVPSVLA;WVQETIAGN;YAEVGRIGYVSG;YTLNSEKH;YTLNSEKHWTN;YVGKNQLVE 54 55.9 0 53.278 16.6219 16.6081 16.6365 16.1752 16.4789 16.309 17.301 17.2856 17.316 17.2006 17.2244 17.2685 17.0966 17.1647 17.0784 P19708 SAA_CANLF Serum amyloid A protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA)] SAA1 Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953] high-density lipoprotein particle [GO:0034364] DMREANYKNSDKYFHA;DPNHFRPAG;DPNHFRPAGLPD;DPNHFRPAGLPDKY;ENSQRITDLL;FGDSGHGAEDSKADQAANE;FRPAGLPDKY;GNYDAAQRGPG;GNYDAAQRGPGG;GNYDAAQRGPGGA;GRSGKDPNHFRPAGLPD;GRSGKDPNHFRPAGLPDKY;KDPNHFRPAGLPD;KDPNHFRPAGLPDKY;NHFRPAGLPD;NHFRPAGLPDKY;PNHFRPAGL;PNHFRPAGLPD;PNHFRPAGLPDK;PNHFRPAGLPDKY;RPAGLPDKY;SDMREANYKNSDKYFHA;SGKDPNHFRPAGLPD;SGKDPNHFRPAGLPDKY;VISDAREN;VSGQWYSFVSEA;YDAAQRGPGGA 27 74.4 0 24.204 13.3105 12.8076 13.8413 0 0 0 0 12.0303 12.0985 7.90147 9.09906 0 15.6261 15.8862 15.8257 P24643 CALX_CANLF Calnexin (pp90) CANX Canis lupus familiaris (Dog) (Canis familiaris) clathrin-dependent endocytosis [GO:0072583]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; synaptic vesicle endocytosis [GO:0048488] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; presynapse [GO:0098793] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; unfolded protein binding [GO:0051082] EDMDGEWEAPQIANPKCESAP;GVWQRPMIDNPNYKGK;IPDPDAVKPDDWNEDA;PNYQGIWKPRKIPNP;VGQMIEAAEERPWL 5 13.8 0.96334 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.20688 P27799 S6A12_CANLF Sodium- and chloride-dependent betaine transporter (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) SLC6A12 Canis lupus familiaris (Dog) (Canis familiaris) amino acid transport [GO:0006865]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725] basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886] gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332] CISWVYGADRFYDNIEDM;CLVTASMDMFPSQL;EEGEKLDQEGEDQ;LILAIAVFCYLAGL;PYFIFFFTCGIPVFFLEVALGQ;TSPVMEFWE 6 14.7 1.002 -0.65003 10.7289 8.59518 0 0 0 0 7.55228 0 11.7092 0 10.7627 0 0 0 0 P28228 CXG1_CANLF Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) GJC1 GJA7 Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267] connexin complex [GO:0005922] gap junction channel activity [GO:0005243] DLETLQREIKMV;LEETEEDHEEDPMMYPE;VGKIWLTVLIAFRIA 3 11.1 0.84897 0.15054 8.22848 0 0 0 7.04701 0 0 0 0 0 0 0 7.48261 0 0 P29794 GLUC_CANLF Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] GCG Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; glucose homeostasis [GO:0042593]; negative regulation of apoptotic process [GO:0043066]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein kinase A signaling [GO:0010737]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823] extracellular space [GO:0005615] glucagon receptor binding [GO:0031769]; hormone activity [GO:0005179] FTSDVSSY;WQRSLQDTEEKSRSFSAPQT 2 15.6 1.0037 -1.0551 0 0 0 0 0 0 0 0 0 0 0 0 6.41193 6.20395 0 P30552 GASR_CANLF Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) CCKBR Canis lupus familiaris (Dog) (Canis familiaris) phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204] plasma membrane [GO:0005886] cholecystokinin receptor activity [GO:0004951]; gastrin receptor activity [GO:0015054] AGEDGDGC;AKLLAKKRVVRMLLVIVVLF;GPAPPNGS;RGGAGPGP;TPGPGGGP 5 11 1.0018 -1.3202 0 0 0 0 0 5.22079 0 6.11956 0 0 0 0 0 11.1884 0 P31637 SC5A3_CANLF Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) SLC5A3 SMIT Canis lupus familiaris (Dog) (Canis familiaris) fucose transmembrane transport [GO:0015756]; glucose transmembrane transport [GO:1904659]; inositol metabolic process [GO:0006020]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; polyol transmembrane transport [GO:0015791] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886] fucose transmembrane transporter activity [GO:0015150]; glucose:sodium symporter activity [GO:0005412]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; polyol transmembrane transporter activity [GO:0015166] DALKMLRNPTDEDVP;EQIRTTTFW;LFADDIACINPE;PGMISRILFADDIACINPEHCM;PTDEDVPWPGFVLGQT;QMYLYIQE 6 8.8 1.0032 -2.3311 9.72064 0 0 12.338 0 12.4073 11.936 0 0 0 0 9.40589 0 11.2 0 P32308 OPSD_CANLF Rhodopsin RHO Canis lupus familiaris (Dog) (Canis familiaris) absorption of visible light [GO:0016038]; cellular response to light stimulus [GO:0071482]; G protein-coupled opsin signaling pathway [GO:0016056]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; visual perception [GO:0007601] membrane [GO:0016020]; photoreceptor disc membrane [GO:0097381]; photoreceptor inner segment membrane [GO:0060342]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886] 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; metal ion binding [GO:0046872] AEKEVTRMVIIMVIAFLICWVPYAS;FRNCMITTLCCGKN 2 11.2 0.9317 0.096502 0 0 0 0 0 0 0 0 3.28309 0 0 0 7.09001 0 0 P33703 APOH_CANLF Beta-2-glycoprotein 1 (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) APOH Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] heparin binding [GO:0008201] ATNNSLYGNKAVFE;TIEIPKCFKE;VTCPPPSV;YTEDAECIDGTI 4 12.2 1.0017 -1.8148 8.28188 0 0 0 0 8.36798 0 0 0 0 1.6345 0 0 0 0 P33704 ATP4B_CANLF Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain) ATP4B Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; sodium ion export across plasma membrane [GO:0036376] apical plasma membrane [GO:0016324]; sodium:potassium-exchanging ATPase complex [GO:0005890] ATPase activator activity [GO:0001671] WVDLVNILHNFL;YCWNPDTGQML 2 7.9 0.98965 -0.53062 0 0 0 0 0 0 0 0 10.5007 8.99226 0 0 0 0 0 P33707 EPO_CANLF Erythropoietin EPO Canis lupus familiaris (Dog) (Canis familiaris) erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Ras protein signal transduction [GO:0046579] extracellular space [GO:0005615] cytokine activity [GO:0005125]; erythropoietin receptor binding [GO:0005128]; hormone activity [GO:0005179]; protein kinase activator activity [GO:0030295] DTKVNFYTWKR;EPAPPKPTQ 2 9.7 0.98985 -0.51014 0 0 0 0 0 0 8.93537 0 0 0 0 0 0 0 0 P33724 CAV1_CANLF Caveolin-1 (Vesicular integral-membrane protein VIP21) CAV1 CAV Canis lupus familiaris (Dog) (Canis familiaris) caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; negative regulation of endothelial cell proliferation [GO:0001937]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane raft [GO:0044860]; receptor internalization [GO:0031623]; regulation of cytosolic calcium ion concentration [GO:0051480]; T cell costimulation [GO:0031295]; vesicle organization [GO:0016050] caveola [GO:0005901]; cytoplasmic vesicle [GO:0031410]; endosome [GO:0005768]; exocytic vesicle [GO:0070382]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471] molecular adaptor activity [GO:0060090]; oxysterol binding [GO:0008142]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325] WFYRLLSALFGI 1 6.7 0.95326 0.05044 0 0 0 0 0 0 0 0 0 0 9.9911 0 0 0 0 P33729 ICAM1_CANLF Intercellular adhesion molecule 1 (ICAM-1) (CD antigen CD54) ICAM1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609] plasma membrane [GO:0005886] integrin binding [GO:0005178] GVVVSLSG;SPRGEITREVVI 2 3.8 0.98953 -0.21548 0 0 0 0 0 0 16.125 0 0 0 6.50548 0 0 0 0 P33730 LYAM2_CANLF E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE Canis lupus familiaris (Dog) (Canis familiaris) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte tethering or rolling [GO:1903238]; response to cytokine [GO:0034097] external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615] calcium ion binding [GO:0005509]; oligosaccharide binding [GO:0070492]; sialic acid binding [GO:0033691] EEIKYLNSMFTYTPTYYWIGIRKV;IYIKRDKDSGKWNDERCDKKKLALC;MTCTFECEEGFE;VASFLLWLLKRLRKRAKK 4 12.9 0.98823 -0.49132 0 0 0 0 6.91109 0 0 0 0 0 0 0 0 5.79649 10.5441 P35521 ICLN_CANLF "Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln))" CLNS1A ICLN Canis lupus familiaris (Dog) (Canis familiaris) "cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; mRNA cis splicing, via spliceosome [GO:0045292]; potassium ion transmembrane transport [GO:0071805]; spliceosomal snRNP assembly [GO:0000387]" cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; methylosome [GO:0034709]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681] intracellularly calcium-gated chloride channel activity [GO:0005229]; lipid binding [GO:0008289]; potassium channel activity [GO:0005267]; small molecule binding [GO:0036094]; splicing factor binding [GO:1990935] FSLEYPTISLHA;GTLYIAES;ISLHAVSRDLNAYPREH 3 13.6 1.004 -1.0539 0 9.15132 4.6893 3.08741 0 0 0 0 8.30328 0 0 0 0 0 0 P38486 LEG3_CANLF Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) LGALS3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; eosinophil chemotaxis [GO:0048245]; innate immune response [GO:0045087]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; mRNA processing [GO:0006397]; negative regulation of endocytosis [GO:0045806]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neutrophil chemotaxis [GO:0030593]; positive chemotaxis [GO:0050918]; positive regulation of calcium ion import [GO:0090280]; RNA splicing [GO:0008380] collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; immunological synapse [GO:0001772]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681] disaccharide binding [GO:0048030]; IgE binding [GO:0019863]; laminin binding [GO:0043236] NQPAGAGG;QPSAPGAY;SDHFKVAVNDAHLL;YPPPGQPSAPGA 4 11.8 1.0032 -2.3715 10.9555 0 0 8.78175 8.51617 0 3.80777 0 0 0 0 0 10.4301 8.50581 0 P39881 CUX1_CANLF Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Clox-1) (Homeobox protein Clox) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] CUX1 CLOX CUTL1 Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]" FGHYVLGLSQGSVSE;GVWKDHWWSTV;PSARSSGAAPSSEGD;PSRRPGARAKPRRRRRRR;PWNKLTVRGKEPF;RRPGARAKPRRRRRRR;SLKKPPTA;SSEGDSCDGVEAAEGPGAAD;YMYQEVDTIELT 9 11 0.99252 -0.17143 0 0 0 0 6.57286 0 0 0 0 0 0 9.22347 4.70543 0 0 P41323 IL6_CANLF Interleukin-6 (IL-6) IL6 Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953]; glucose homeostasis [GO:0042593]; hepatocyte proliferation [GO:0072574]; interleukin-6-mediated signaling pathway [GO:0070102]; liver regeneration [GO:0097421]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of multicellular organismal process [GO:0051240]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]; T-helper 17 cell lineage commitment [GO:0072540]; vascular endothelial growth factor production [GO:0010573] extracellular space [GO:0005615]; interleukin-6 receptor complex [GO:0005896] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-6 receptor binding [GO:0005138] TCLTRITTGLVEFQLHLN 1 8.7 0.97156 0.048313 0 8.83185 0 0 0 0 0 0 0 0 0 0 0 0 0 P43240 AGTR1_CANLF Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1 receptor) AGTR1 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; maintenance of blood vessel diameter homeostasis by renin-angiotensin [GO:0002034]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of vasoconstriction [GO:0019229] plasma membrane [GO:0005886] angiotensin type I receptor activity [GO:0001596]; angiotensin type II receptor activity [GO:0004945] SIIFVVGIFGNSLVVIV 1 4.7 0.98606 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.52974 P43698 TITF1_CANLF Thyroid transcription factor 1 (TTF-1) (Homeobox protein Nkx-2.1) (Thyroid nuclear factor 1) TITF1 TTF1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357] nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" GGGGGGGA;GGGGGGGG;GHAQQQAQQQAQAAQ 3 6.5 0.95152 0.053889 0 0 0 0 0 8.77007 0 0 0 0 0 0 0 0 0 P47983 ZP2_CANLF Zona pellucida sperm-binding protein 2 (Zona pellucida glycoprotein 2) (Zp-2) (Zona pellucida protein A) [Cleaved into: Processed zona pellucida sperm-binding protein 2] ZP2 ZPA Canis lupus familiaris (Dog) (Canis familiaris) binding of sperm to zona pellucida [GO:0007339]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; prevention of polyspermy [GO:0060468] collagen-containing extracellular matrix [GO:0062023]; egg coat [GO:0035805]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; inclusion body [GO:0016234]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886] acrosin binding [GO:0032190]; structural constituent of egg coat [GO:0035804] IVSLPGPILLLA;SLVYFHCTAL;VICHENKMTVEFPRDL 3 5.3 0.98954 -0.19712 0 0 0 0 0 0 10.4416 0 0 0 0 0 0 0 5.62226 P48411 IL10_CANLF Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) IL10 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of cytokine production [GO:0001819]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; response to glucocorticoid [GO:0051384]; response to molecule of bacterial origin [GO:0002237] extracellular region [GO:0005576]; extracellular space [GO:0005615] cytokine activity [GO:0005125]; interleukin-10 receptor binding [GO:0005141] SLGEKLKTLRLRLRLRR 1 9.4 0.97925 0.046227 0 0 0 0 4.53381 0 0 0 0 0 0 0 0 0 0 P49256 LMAN2_CANLF Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) LMAN2 Canis lupus familiaris (Dog) (Canis familiaris) "endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]" cell surface [GO:0009986]; COPI-coated vesicle [GO:0030137]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; exocytic vesicle [GO:0070382]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886] D-mannose binding [GO:0005537]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872] DGNSEHLKREH;MVEHTPDEENIDWTK 2 7.3 0.98399 -0.24753 0 0 0 0 0 0 0 0 0 0 0 0 0 5.88667 0 P49822 ALBU_CANLF Albumin (allergen Can f 3) ALB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to calcium ion starvation [GO:0072732]; cellular response to starvation [GO:0009267]; negative regulation of mitochondrial depolarization [GO:0051902] cytoplasm [GO:0005737]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991] DNA binding [GO:0003677]; enterobactin binding [GO:1903981]; fatty acid binding [GO:0005504]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; toxic substance binding [GO:0015643] AHRYNDLGEEHFRGLVL;AYKSEIAH;AYKSEIAHR;AYKSEIAHRY;AYKSEIAHRYN;AYKSEIAHRYND;AYKSEIAHRYNDL;AYKSEIAHRYNDLG;AYKSEIAHRYNDLGEEHFRGLVL;CCATDDPPTC;DLGEEHFRGLVL;DLPSLAAD;DLPSLAADFVEDK;EAYKSEIA;EAYKSEIAH;EAYKSEIAHR;EAYKSEIAHRY;EAYKSEIAHRYN;EAYKSEIAHRYND;EAYKSEIAHRYNDL;EAYKSEIAHRYNDLG;EAYKSEIAHRYNDLGE;EAYKSEIAHRYNDLGEE;EAYKSEIAHRYNDLGEEH;EAYKSEIAHRYNDLGEEHF;EAYKSEIAHRYNDLGEEHFRG;EAYKSEIAHRYNDLGEEHFRGL;EAYKSEIAHRYNDLGEEHFRGLVL;EEGPKLVAAAQAALV;EEHFRGLVL;EFKPLVDEPQ;EGPKLVAAAQAAL;EGPKLVAAAQAALV;EHFRGLVL;EIAHRYNDLGEEHFRGLVL;EKLGEYGFQNALL;EPQNLVKTN;ETYVPKEFNA;ETYVPKEFNAE;EVDETYVPK;EYGFQNAL;EYGFQNALL;EYGFQNALLVRY;FGAFVEKCCAAENKEGCF;FPPLVAPE;FQNALLVRY;FSEEGPKLVAAAQAALV;GEEHFRGLVL;GEYGFQNALL;GEYGFQNALLVRY;GFQNALLVRY;GPKLVAAAQAAL;GPKLVAAAQAALV;HRYNDLGEEHFRGLVL;IAHRYNDLGEEHFRGLVL;KAPQVSTPTL;KLGEYGFQNAL;KLGEYGFQNALL;KLVAAAQAALV;KPLVDEPQ;KSEIAHRYN;LEVDETYVPKEF;LEVDETYVPKEFN;LEVDETYVPKEFNA;LEVDETYVPKEFNAE;LEVDETYVPKEFNAETF;LGEEHFRGLVL;LGEYGFQNALL;LPSLAADF;LVAAAQAALV;LVKTNCELFEKLGEYGFQNALLVRY;LVRYTKKA;LVRYTKKAPQVS;LVRYTKKAPQVSTPTL;NDLGEEHF;NDLGEEHFRG;NDLGEEHFRGLVL;NDLGEEHFRGLVLV;NDLGEEHFRGLVLVA;NPGFPPLVAPEPD;PGFPPLVA;PKLVAAAQ;PKLVAAAQA;PKLVAAAQAA;PKLVAAAQAAL;PKLVAAAQAALV;RDELPGDLPSLAAD;RYNDLGEEHFRGLVL;SEEGPKLVAAAQAALV;SEIAHRYNDLGEEHF;SEIAHRYNDLGEEHFR;SEIAHRYNDLGEEHFRGLVL;SVARLSQRFPKAD;SVARLSQRFPKADF;TKKAPQVSTPTL;TVASLRDKYG;TYVPKEFN;TYVPKEFNA;TYVPKEFNAE;TYVPKEFNAET;TYVPKEFNAETF;TYVPKEFNAETFTFHA;VAAAQAALV;VAFSQYLQ;VAFSQYLQQ;VELLKHKPKATD;VEVSRKLG;VEVSRKLGKVG;VPKEFNAE;VRYTKKAPQVSTPTL;YKSEIAHR;YKSEIAHRY;YKSEIAHRYNDL;YKSEIAHRYNDLG;YKSEIAHRYNDLGEEHFRGLVL;YNDLGEEHFRGLVL 116 37 0 296.3 19.3363 19.8737 19.9529 18.8777 19.2144 19.1165 20.1819 20.1863 20.3707 17.5979 17.5187 17.626 20.1758 20.4033 20.4113 P49894 IOD1_CANLF Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) DIO1 ITDI1 TXDI1 Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446]; thyroid hormone metabolic process [GO:0042403] endoplasmic reticulum membrane [GO:0005789] thyroxine 5'-deiodinase activity [GO:0004800] FGSCTUPSFLF;GSCTUPSFLFKFDQ;LYSMQYFWFVLKVQWQRLEDRTE;TLYSMQYFWFVLKVQW;VLWLRRLWVLL 5 20.5 0.99288 -0.16644 0 0 6.08837 0 0 0 0 11.6711 5.51756 0 0 0 0 0 0 P49926 CRF_CANLF Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) CRH Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of epinephrine secretion [GO:0032811]; negative regulation of glucagon secretion [GO:0070093]; positive regulation of cortisol secretion [GO:0051464] extracellular space [GO:0005615] corticotropin-releasing hormone activity [GO:0017045] PVLYRMGEE 1 4.6 1.0038 -0.80421 0 0 0 0 0 0 0 0 0 6.84059 0 0 0 0 0 P50994 ANXA4_CANLF Annexin A4 (36 kDa zymogen granule membrane-associated protein) (ZAP36) (Annexin IV) (Annexin-4) (Lipocortin IV) ANXA4 ANX4 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; zymogen granule membrane [GO:0042589] calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786] FLDDALMRQDAQ;PEELRCINQTYQ;QEIRTAYKSTIGRDLMDDL 3 13.5 0.99308 -0.16039 0 0 0 0 9.63637 8.22704 0 0 9.88225 0 0 0 0 0 0 P50997 AT1A1_CANLF Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) ATP1A1 Canis lupus familiaris (Dog) (Canis familiaris) intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of sodium ion transport [GO:0002028]; sodium ion export across plasma membrane [GO:0036376] axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391] DRTVMGRIATLASGLEGGQT;EGFQFDTDDVNFPVENLCFVG;HGDKKKAK;QQWTYEQRKIVEFTCHTAFFVSI;TSEQLDGILKYHTEI;VLGFRHLFLPDEQFPEG 6 10 1.0024 -1.7953 0 9.04977 0 9.64355 10.332 0 9.12192 0 0 7.73633 0 8.97484 0 0 0 P51147 RAB5C_CANLF Ras-related protein Rab-5C (EC 3.6.5.2) RAB5C Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227] early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; exocytic vesicle [GO:0070382]; lipid droplet [GO:0005811]; melanosome [GO:0042470]; plasma membrane [GO:0005886] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] GVDLQENSPASRSQCCSN 1 8.3 0.97283 0.048313 0 0 0 0 0 0 0 0 0 0 0 5.5363 0 0 0 P51154 RB22A_CANLF Ras-related protein Rab-22A (Rab-22) RAB22A RAB22 Canis lupus familiaris (Dog) (Canis familiaris) endocytosis [GO:0006897]; intracellular protein transport [GO:0006886] early endosome [GO:0005769]; endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; ruffle [GO:0001726] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] QEAFRALAPMYYRG;SGGKGFKL 2 11.3 0.98312 -0.25577 0 0 0 0 0 0 9.9322 0 0 0 0 0 0 0 0 P52203 CCL2_CANLF C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2) CCL2 MCP1 SCYA2 Canis lupus familiaris (Dog) (Canis familiaris) "antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; sensory perception of pain [GO:0019233]" extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] VTSSKCPKEAVIFKT 1 14.9 0.95119 0.053899 0 6.10622 0 0 0 0 0 0 0 0 0 0 0 0 0 P52212 PTHY_CANLF Parathyroid hormone (PTH) (Parathyrin) PTH Canis lupus familiaris (Dog) (Canis familiaris) cell-cell signaling [GO:0007267]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725] extracellular space [GO:0005615] hormone activity [GO:0005179]; parathyroid hormone receptor binding [GO:0031856]; peptide hormone receptor binding [GO:0051428] ESYQKSLGEADKADV 1 13 0.94066 0.075658 0 0 0 0 0 0 0 0 0 10.6386 0 0 0 0 0 P54831 TGFB1_CANLF Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] TGFB1 Canis lupus familiaris (Dog) (Canis familiaris) ATP biosynthetic process [GO:0006754]; cell-cell junction organization [GO:0045216]; cellular response to transforming growth factor beta stimulus [GO:0071560]; chondrocyte differentiation [GO:0002062]; epithelial to mesenchymal transition [GO:0001837]; extracellular matrix assembly [GO:0085029]; extrinsic apoptotic signaling pathway [GO:0097191]; hematopoietic progenitor cell differentiation [GO:0002244]; hyaluronan catabolic process [GO:0030214]; membrane protein intracellular domain proteolysis [GO:0031293]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of skeletal muscle tissue development [GO:0048642]; odontoblast differentiation [GO:0071895]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; positive regulation of microglia differentiation [GO:0014008]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein secretion [GO:0050714]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor catabolic process [GO:0032801]; regulation of cell population proliferation [GO:0042127]; response to cholesterol [GO:0070723]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179] blood microparticle [GO:0072562]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]; type III transforming growth factor beta receptor binding [GO:0034714] GLRLLPLLLPLLRLL;GLRLLPLLLPLLRLLVL;GVVRQWLSH;IRGQILSKLRLSSPP;LYQKYSNDSW;MATPLERAQHLHSSR;PPSGLRLLPLLLPLLRLLVLTPGRP;PSGLRLLPLLLPLLRLL;PSGLRLLPLLLPLLRLLVLT;STRDRVAGESAEP;YEKVKKSPHSIYMLF 11 26.2 0.95366 0.053902 0 0 0 0 0 0 0 5.00796 0 0 0 0 0 0 0 P54834 TYRO_CANLF Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase) TYR Canis lupus familiaris (Dog) (Canis familiaris) melanin biosynthetic process [GO:0042438]; pigmentation [GO:0043473]; response to blue light [GO:0009637] melanosome [GO:0042470]; melanosome membrane [GO:0033162] metal ion binding [GO:0046872]; tyrosinase activity [GO:0004503] TLEGFASPLTGIADA;YSNLQESERDIFQDY 2 5.7 0.98679 -0.23174 0 0 0 10.6637 0 0 0 0 0 0 0 0 0 0 0 P55261 CBPB1_CANLF Carboxypeptidase B (EC 3.4.17.2) (47 kDa zymogen granule membrane-associated protein) (ZAP47) CPB1 CPB Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] cytoplasmic vesicle [GO:0031410]; extracellular space [GO:0005615] metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270] AIFMDCGFHAREWISPAFWQWFVRE;DSVTQIKPHSTAD;FLKQNELHYEV;TVEDFLKQNELHYEV 4 12.7 0.98614 -0.41677 0 0 0 0 0 9.15942 9.24786 0 0 0 0 0 0 10.9761 0 P55745 RAB21_CANLF Ras-related protein Rab-21 RAB21 Canis lupus familiaris (Dog) (Canis familiaris) protein stabilization [GO:0050821]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482] cleavage furrow [GO:0032154]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] AAGGGGGG;QSSGGGCC;VLLGEGCVGKTSLV 3 13.5 0.94145 0.061087 0 0 0 0 0 0 0 0 0 9.87306 0 0 0 0 0 P56497 EDNRB_CANLF Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; developmental pigmentation [GO:0048066]; endothelin receptor signaling pathway [GO:0086100]; enteric nervous system development [GO:0048484]; regulation of blood pressure [GO:0008217]; vasoconstriction [GO:0042310] plasma membrane [GO:0005886] endothelin receptor activity [GO:0004962] ALSIDRYRAVAS;AVGFDMITIDYKG;FSFYFCLPL;MCKLVPFIQKASVGITV;VLACGLSRIWGEERGFPPD;VVSCLVFVLGII 6 18.6 1.0013 -0.94676 11.0684 5.53531 0 0 0 0 0 0 0 0 0 0 9.07119 9.63762 0 P56513 PLM_CANLF Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) FXYD1 PLM Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of protein glutathionylation [GO:0010734]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903406]; sodium ion transport [GO:0006814] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315] sodium channel regulator activity [GO:0017080] IVLSRRCRCKFNQ 1 14.1 0.93876 0.059747 0 0 0 0 0 0 0 0 7.85568 0 0 0 0 0 0 P56592 CP1A2_CANLF Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P450-D2) (DAH2) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) CYP1A2 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; retinol metabolic process [GO:0042572] endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231] aromatase activity [GO:0070330]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497] LASTIFCL;NPEIQRQIQKELDTV;VTTAISWSLMYLVA 3 7.2 0.95213 0.053887 7.00663 0 0 0 0 0 0 0 0 0 0 0 0 0 0 P56595 APOC1_CANLF Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I] APOC1 Canis lupus familiaris (Dog) (Canis familiaris) lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157]; negative regulation of cholesterol transport [GO:0032375]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; triglyceride metabolic process [GO:0006641]; very-low-density lipoprotein particle clearance [GO:0034447] high-density lipoprotein particle [GO:0034364]; very-low-density lipoprotein particle [GO:0034361] fatty acid binding [GO:0005504]; phospholipase inhibitor activity [GO:0004859] AGEISSTFER;AGEISSTFERIPD;AGEISSTFERIPDK;AGEISSTFERIPDKL;AGEISSTFERIPDKLK;AGEISSTFERIPDKLKE;AGEISSTFERIPDKLKEF;AGEISSTFERIPDKLKEFG;EFGNTLEDKA;EISSTFERIPD;FSEAFKKVKEHLKTAFS;GEISSTFERIPD;TLEDKARAAIESIKKS 13 60.2 0 21.648 14.2286 14.6274 14.3635 8.74688 0 0 13.8373 14.8541 14.5078 11.9078 12.4504 12.7519 14.2305 14.0363 13.8486 P60524 HBB_CANLF Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) HBB Canis lupus familiaris (Dog) (Canis familiaris) cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744] haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; hemoglobin alpha binding [GO:0031721]; metal ion binding [GO:0046872]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AAYQKVVAGVANALAHKYH;ANALAHKYH;EEKSLVSGL;EVGGEALGRLL;GKVNVDEVGG;GVANALAHKYH;KVVAGVANALAHKYH;PENFKLLG;PENFKLLGNVL;QKVVAGVANALAHKYH;TAEEKSLVSGL;TFAKLSELH;TPQVQAAYQKVVAGVANALAHKYH;VANALAHKYH;VHLTAEEK;VHLTAEEKS;VHLTAEEKSL;VHLTAEEKSLV;VHLTAEEKSLVS;VHLTAEEKSLVSG;VHLTAEEKSLVSGL;VHLTAEEKSLVSGLWG;VHLTAEEKSLVSGLWGKVNVDEVG;VVAGVANALAHKYH;YQKVVAGVANALAH;YQKVVAGVANALAHKYH 26 52.1 0 56.439 15.2613 15.6796 15.5145 15.7475 15.8047 15.8539 17.1412 17.2031 17.1143 12.925 13.0659 12.0232 15.7718 15.6908 14.9551 P60529 HBA_CANLF Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] HBA Canis lupus familiaris (Dog) (Canis familiaris) cellular oxidant detoxification [GO:0098869]; hydrogen peroxide catabolic process [GO:0042744] haptoglobin-hemoglobin complex [GO:0031838]; hemoglobin complex [GO:0005833] heme binding [GO:0020037]; iron ion binding [GO:0005506]; organic acid binding [GO:0043177]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] AAVSTVLTSKYR;ADALTTAVAHLD;AHGKKVADALTTAVAHLD;ALSALSDLHA;ALSALSDLHAYKL;ALTTAVAH;ALTTAVAHL;ALTTAVAHLD;ALTTAVAHLDDLPG;ALTTAVAHLDDLPGAL;AVAHLDDLPGAL;DALTTAVAHL;DALTTAVAHLD;DKIGGHAGDYG;DKIGGHAGDYGGEAL;DLPGALSALSDLHAYKL;DLPGALSALSDLHAYKLRVD;DPVNFKLL;DRTFQSFPTTKTYFPHF;DRTFQSFPTTKTYFPHFDLSPG;DRTFQSFPTTKTYFPHFDLSPGSA;EALDRTFQ;FAAVSTVLTSKY;FAAVSTVLTSKYR;FDLSPGSAQV;FPHFDLSPG;FPHFDLSPGSA;FPHFDLSPGSAQV;FPTTKTYFPHFD;FPTTKTYFPHFDLSPGSAQV;GEALDRTF;GEALDRTFQ;GEALDRTFQSF;GGEALDRTFQ;GGEALDRTFQSF;GHAGDYGGEAL;GHAGDYGGEALD;GHAGDYGGEALDRTFQ;HAGDYGGEAL;HAGDYGGEALD;HFDLSPGSA;HFDLSPGSAQV;IGGHAGDYGGEALD;KIGGHAGDYGGEALD;KKVADALTT;LPGALSALSDLHAYKLRVD;LSPADKTNIK;LSPADKTNIKS;LSPADKTNIKST;LTTAVAHLD;PADKTNIK;PADKTNIKST;PHFDLSPGSAQV;PTTKTYFPHFDLSPGSAQV;PVNFKLLSH;RTFQSFPTT;RTFQSFPTTKTYFPHFDLSPGSAQV;SALSDLHA;SALSDLHAYKLRVD;SDLHAYKLRVD;SFPTTKTYFPHFDLSPG;SFPTTKTYFPHFDLSPGSAQV;SLDKFFAAVST;SPADKTNIK;SPADKTNIKS;SPADKTNIKST;SPADKTNIKSTWDK;SPADKTNIKSTWDKIG;SPADKTNIKSTWDKIGG;SPADKTNIKSTWDKIGGHA;TFQSFPTTKTYFPHFD;TPAVHASLDKFFAAVSTVLTSKYR;TTAVAHLD;TTAVAHLDDLPG;TTKTYFPHFDLSPGSAQV;TYFPHFDL;TYFPHFDLSPG;TYFPHFDLSPGSAQV;VAHLDDLPGAL;VDPVNFKLL;VLSPADKT;VLSPADKTN;VLSPADKTNI;VLSPADKTNIK;VLSPADKTNIKS;VLSPADKTNIKST;VLSPADKTNIKSTW;VLSPADKTNIKSTWD;VLSPADKTNIKSTWDK;VLSPADKTNIKSTWDKIG;VLSPADKTNIKSTWDKIGG;VLSPADKTNIKSTWDKIGGH;VLSPADKTNIKSTWDKIGGHA;VLSPADKTNIKSTWDKIGGHAG;VLSPADKTNIKSTWDKIGGHAGD;VLSPADKTNIKSTWDKIGGHAGDY;VLSPADKTNIKSTWDKIGGHAGDYG;VSTVLTSKY;VSTVLTSKYR;YFPHFDLSPGSAQV;YGGEALDRTF 101 89.4 0 2.4395 0 0 10.9858 10.3815 11.7928 11.1596 12.2715 12.3004 12.3461 0 4.12093 0 9.70919 0 0 P63050 RL40_CANLF Ubiquitin-ribosomal protein eL40 fusion protein (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (CEP52)] UBA52 UBCEP2 B9 Canis lupus familiaris (Dog) (Canis familiaris) modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synapse [GO:0045202] protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625] CRKKKCGHTNN;FAGKQLEDGRT 2 17.2 0.98182 0.035491 0 0 0 0 0 0 10.2855 0 0 0 0 0 0 0 0 P79148 ADRB1_CANLF Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of heart contraction [GO:0045823]; positive regulation of MAPK cascade [GO:0043410]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]" early endosome [GO:0005769]; plasma membrane [GO:0005886] beta1-adrenergic receptor activity [GO:0004940] DDDDDDEDDAGAGAGAA;HWWRAGGDEARRCYNDPKCCD;IVLLIVAGNVLVIAAIAKTPRLQT;LMHWWRAGGDE;MHWWRAGGDEARRCYNDPKC;PGAASDDDDDDEDDAG;SDDDDDDE;SDDDDDDEDDA;SDDDDDDEDDAGA;SPGAASDDDDDDEDDAG 10 14.8 0.85983 0.19051 0 0 0 3.146 5.68731 0 0 0 0 5.83453 0 0 0 0 3.36583 P79250 5HT1B_CANLF 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (5-HTR1B) (5-HT1D subtype beta) (Serotonin receptor 1B) HTR1B Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to temperature stimulus [GO:0071502]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor internalization [GO:0002031]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of serotonin secretion [GO:0014063]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of behavior [GO:0050795]; vasoconstriction [GO:0042310]" dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; G protein-coupled serotonin receptor complex [GO:0098666]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; serotonergic synapse [GO:0099154] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378] NTDHILYTVYST;PWKVLLVILLALITLATTLS 2 8.2 0.99113 -0.19477 0 0 0 0 0 0 0 0 0 0 0 8.53407 0 0 5.51772 P81708 LYSC1_CANLF "Lysozyme C, milk isozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)" Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; killing of cells of another organism [GO:0031640] lysozyme activity [GO:0003796]; metal ion binding [GO:0046872] KLKSMGMD 1 6.2 1.0044 -1.1044 0 0 2.24671 0 0 0 0 0 0 0 0 11.5112 0 0 0 P81709 LYSC2_CANLF "Lysozyme C, spleen isozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)" Canis lupus familiaris (Dog) (Canis familiaris) defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing of cells of another organism [GO:0031640] lysozyme activity [GO:0003796] PGSKSTDYGIF 1 8.5 0.98424 0.035491 0 6.79064 0 0 0 0 0 0 0 8.68324 0 0 0 0 0 P86229 KTAP2_CANLF Keratinocyte-associated protein 2 (KCP-2) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2) (Oligosaccharyl transferase subunit KCP2) KRTCAP2 KCP2 Canis lupus familiaris (Dog) (Canis familiaris) protein N-linked glycosylation via arginine [GO:0042543] oligosaccharyltransferase complex [GO:0008250] enzyme activator activity [GO:0008047] VTTCFIFSMVGLYYINKI 1 13.2 0.98428 -0.23977 0 9.25321 0 0 0 0 0 0 0 0 0 0 0 0 0 P99502 GRP75_CANLF "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Canis lupus familiaris (Dog) (Canis familiaris) calcium import into the mitochondrion [GO:0036444]; erythrocyte differentiation [GO:0030218]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; regulation of erythrocyte differentiation [GO:0045646] cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634] ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; unfolded protein binding [GO:0051082] EDRRKKVTTFS 1 1.7 0.98087 0.035491 0 0 0 0 0 0 9.90121 0 0 0 0 0 0 0 0 Q004A7 Q004A7_CANLF Carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1S CEACAM1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] RGQLQVFHDSTEQ;VIAALVYLQYFRKT 2 14.4 0.93731 0.059741 0 0 0 0 0 0 0 0 0 0 0 0 8.79093 0 0 Q00LT6 Q00LT6_CANLF Progressive rod-cone degeneration PRCD Canis lupus familiaris (Dog) (Canis familiaris) photoreceptor outer segment membrane [GO:0042622] VGSRSERDLQ 1 47.6 0.989 -0.26284 0 0 0 0 0 0 10.0001 0 0 0 0 0 0 0 0 Q01685 TRAM1_CANLF Translocating chain-associated membrane protein 1 (Protein TRAM1) TRAM1 TRAM Canis lupus familiaris (Dog) (Canis familiaris) "protein insertion into ER membrane [GO:0045048]; response to unfolded protein [GO:0006986]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" endoplasmic reticulum membrane [GO:0005789] AYPHNLMTFQMKFFYIA;AYWFHAFPELYFQK;QLAYWFHAFPELYFQKTKKED;RKGTENGVNGTVTSNGADS;SKFNESGQLSAFY 5 18.7 1.0001 -0.61434 0 0 11.1654 11.062 7.66974 0 0 6.93499 10.7745 0 10.5647 9.918 0 0 0 Q06SM4 Q06SM4_CANLF Pinin Canis lupus familiaris (Dog) (Canis familiaris) mRNA processing [GO:0006397]; RNA splicing [GO:0008380] desmosome [GO:0030057]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681] DNA binding [GO:0003677] AGEEEEKEAGI;QPQPVLQSQPLCQPET;SSTSGSSS;VEPDKECKSLSP 4 6.5 1.0016 -1.3123 0 0 0 0 0 0 10.0128 10.6075 0 0 0 0 8.15046 0 0 Q075B4 CASPC_CANLF Caspase-12 (CASP-12) (EC 3.4.22.-) Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727] AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP3 inflammasome complex [GO:0072559] cysteine-type endopeptidase activity [GO:0004197] AENEDECSESSSAV;MLNSFLEDLKE;VLNKQELQT 3 8.8 0.98776 -0.40193 0 0 8.95172 7.05767 0 7.3014 0 0 0 0 8.45492 0 0 0 0 Q076A4 MYH8_CANLF "Myosin-8 (Developmental myosin heavy chain neonatal) (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)" MYH8 Canis lupus familiaris (Dog) (Canis familiaris) muscle contraction [GO:0006936] cytoplasm [GO:0005737]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] DLELTLAKVEKEKHATEN;ELTAKKRK;EVIQESRN;ISDLTEQIAEG;PLGIFSILEEECMFPKATDTSFKNK;QAKVKSYK;QLQSEVEEVIQESRNAEEK;RVTFQLKAERSYHIFY;TVVGLYQK 9 5.8 1.0033 -1.0356 0 10.4926 0 0 0 0 0 11.4708 0 0 0 0 0 0 0 Q076A6 MYH1_CANLF "Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain, skeletal muscle, adult 1)" MYH1 Canis lupus familiaris (Dog) (Canis familiaris) muscle contraction [GO:0006936] cytoplasm [GO:0005737]; myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] DLELTLAKVEKEKHATEN;EADSLADAEER;EDMAMMTHLHEPAVLY;ELTAKKRK;ISDLTEQIAEG;MSNKKPDLIEMLLITTNPYDYAF;MSSDQEMAIFGE;RVTFQLKAERSYHIFY;TVVGLYQK;YQIMSNKKPD 10 6.4 1.0021 -1.2334 0 8.14822 0 0 0 8.68257 0 8.02126 10.1586 0 0 0 0 0 0 Q076A7 MYH2_CANLF "Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain, skeletal muscle, adult 2)" MYH2 Canis lupus familiaris (Dog) (Canis familiaris) actin-mediated cell contraction [GO:0070252]; muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; response to activity [GO:0014823] A band [GO:0031672]; actomyosin contractile ring [GO:0005826]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myosin filament [GO:0032982]; myosin II complex [GO:0016460] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; microfilament motor activity [GO:0000146] DLELTLAKVEKEKHATEN;EDMAMMTHLHEPAVLY;ELTAKKRK;ISDLTEQIAEG;MSSDQEMAIFGE;PELIEMLLITTNPYDYPFVSQGE;QAKVKSYK;RVTFQLKAERSYHIFY;SGGAKKGG;TVVGLYQK 10 6.6 1.0029 -2.1623 9.8831 0 0 0 0 0 8.48103 0 0 0 0 0 0 0 0 Q09Y71 Q09Y71_CANLF Truncated nephrocan Canis lupus familiaris (Dog) (Canis familiaris) LQMSSFTRMLALED 1 9.8 0.98538 -0.25901 0 7.20144 0 0 0 0 0 0 0 0 0 0 0 0 0 Q0QEQ8 Q0QEQ8_CANLF isocitrate dehydrogenase (NADP(+)) (EC 1.1.1.42) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 Canis lupus familiaris (Dog) (Canis familiaris) glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; NADP metabolic process [GO:0006739]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisome [GO:0005777] isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] STKNTILKKYDGRFKDIFQE 1 5.5 0.96615 0.048544 5.3512 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q0QEY4 Q0QEY4_CANLF "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1)" SDHB Canis lupus familiaris (Dog) (Canis familiaris) respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099] mitochondrial inner membrane [GO:0005743] "2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; succinate dehydrogenase (quinone) activity [GO:0008177]" VPDLSNFYAQYK 1 4.8 0.99219 -0.19177 0 0 0 0 0 0 0 0 0 0 0 10.5909 0 0 0 Q1HE58 RB27A_CANLF Ras-related protein Rab-27A (EC 3.6.5.2) RAB27A Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; protein secretion [GO:0009306] apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141] G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489] NSKFITTVGIDFRE 1 6.3 0.98818 -0.26022 0 0 0 9.51183 0 0 0 0 0 0 0 0 0 0 0 Q1HGE8 HSF4_CANLF Heat shock factor protein 4 (HSF 4) (Heat shock transcription factor 4) (HSTF 4) HSF4 Canis lupus familiaris (Dog) (Canis familiaris) lens fiber cell differentiation [GO:0070306]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] REVVTLRQ 1 1.6 0.98251 -0.25156 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.50974 Q1JUL3 Q1JUL3_CANLF Interleukin 29 IL-29 Canis lupus familiaris (Dog) (Canis familiaris) cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; defense response to virus [GO:0051607]; positive regulation of immune response [GO:0050778] extracellular region [GO:0005576] cytokine activity [GO:0005125] KPTTTRRGCHMDRF 1 7.4 0.93699 0.063384 0 0 0 0 0 8.99901 0 0 0 0 0 0 0 0 0 Q24LN3 Q24LN3_CANLF RAGE Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] AGIQDEGTF;EVKPEDQGTY 2 4.7 0.98655 -0.38813 0 0 0 0 9.48138 0 0 0 0 0 0 0 0 0 0 Q257A0 Q257A0_CANLF Hexosyltransferase (EC 2.4.1.-) b3galt6 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi membrane [GO:0000139] hexosyltransferase activity [GO:0016758] FAVGTSGL;KHQMLTREGRLCKQEVQL 2 7.9 1.0042 -1.0522 0 0 0 0 0 6.91731 0 0 0 0 0 0 0 0 13.1379 Q258K2 MYH9_CANLF "Myosin-9 (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)" MYH9 Canis lupus familiaris (Dog) (Canis familiaris) "actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; cell adhesion [GO:0007155]; cortical granule exocytosis [GO:0060471]; cytokinetic process [GO:0032506]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte differentiation [GO:0030224]; negative regulation of actin filament severing [GO:1903919]; phagocytosis, engulfment [GO:0006911]; platelet formation [GO:0030220]; positive regulation of protein processing in phagocytic vesicle [GO:1903923]; protein transport [GO:0015031]; regulation of cell shape [GO:0008360]; vesicle targeting [GO:0006903]" actin cytoskeleton [GO:0015629]; actomyosin contractile ring [GO:0005826]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cleavage furrow [GO:0032154]; cortical granule [GO:0060473]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; stress fiber [GO:0001725] actin filament binding [GO:0051015]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; integrin binding [GO:0005178]; microfilament motor activity [GO:0000146]; protein homodimerization activity [GO:0042803]; protein-membrane adaptor activity [GO:0043495] ALEEKRRLE;AQQAADKYLYVDKNF;GIPEEEQMGLLRVI;HQRRTASNLEKKQ;IRICRQGFPNRVV;LEKVTTEAKLKKLE;RHEMPPHIYAITDTAYRSM;TKDFSALESQLQD;VGANIETYLLEK 9 6.2 1.0031 -2.2871 12.6237 5.94326 0 0 0 0 13.882 10.2628 10.8535 0 0 0 0 8.44257 0 Q28226 Q28226_CANLF Mucin Canis lupus familiaris (Dog) (Canis familiaris) glycolytic process [GO:0006096] phosphopyruvate hydratase complex [GO:0000015] magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] GAGCSCCV;GLMMLGVESGVGVGSTHAGGA;IAPALISKN;SEVAGRGT;THYPNTPTTNL 5 5.1 1.0022 -1.8758 0 8.0263 0 0 0 0 10.4683 8.23213 0 0 0 0 0 0 10.0912 Q28243 Q28243_CANLF Fibrinogen A-alpha-chain Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] extracellular region [GO:0005576] DLLPPKDRQ;EVNSEDGSDCGDLSHT;GSTGPGNT;GTWSSGSTGPGSTGPGSTGTWSS;LSHTFAGSLDD;SQLQEAPLEWKA;THIMGSDSDIFTNIG;THIMGSDSDIFTNIGTPEFPSSG 8 28 0.96207 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 5.56499 0 0 Q28256 GP1BA_CANLF Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (CD antigen CD42b) [Cleaved into: Glycocalicin] GP1BA Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; cell adhesion [GO:0007155] plasma membrane [GO:0005886] DCPSPMDGGDMDYDNYDDEDE;GELDTLYLQGNWL;GGDMDYDNYDDED;GNPWSCDCE;HGNPWSCDC;LDGLSHLHEL;MDYDNYDDEDE 7 8 0.98803 -0.48595 0 0 0 0 0 5.34749 0 0 0 0 6.8627 0 0 0 5.9019 Q28265 KCMA1_CANLF "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog)" KCNMA1 KCNMA Canis lupus familiaris (Dog) (Canis familiaris) adult walking behavior [GO:0007628]; cell maturation [GO:0048469]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; eye blink reflex [GO:0060082]; inner ear auditory receptor cell differentiation [GO:0042491]; intracellular potassium ion homeostasis [GO:0030007]; locomotor rhythm [GO:0045475]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; neuromuscular process controlling balance [GO:0050885]; neuronal action potential [GO:0019228]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of aldosterone metabolic process [GO:0032344]; regulation of membrane potential [GO:0042391]; relaxation of vascular associated smooth muscle [GO:0060087]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; saliva secretion [GO:0046541]; sensory perception of sound [GO:0007605]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311] apical plasma membrane [GO:0016324]; caveola [GO:0005901]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; terminal bouton [GO:0043195]; voltage-gated potassium channel complex [GO:0008076] actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; potassium channel activity [GO:0005267]; voltage-gated potassium channel activity [GO:0005249] DEPDNAYPRNIQIEP;DSTGMFHWCAPKE;FIILLWRTLKYLWT;INQYKSTSSLI;LSTMLANLFSIGS;TDLIFCLM;YFGLRFIAANDNLWFWLEVNSVVD 7 8.5 0.98765 -0.49664 9.64555 9.4777 0 0 0 0 0 0 11.5704 0 0 0 0 0 0 Q28269 OCLN_CANLF Occludin OCLN Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of wound healing [GO:0090303]; protein localization to cell leading edge [GO:1902463] apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410] DTGLQEYKSLQ;FAVKTRRKMDR;GFLLAMVAFCFIAALV;TSDQQRQLYKRNFDTG;YRPDEFKPNHYAPSND 5 12.9 1.0024 -0.66692 11.2852 11.2692 12.216 0 0 0 0 12.4738 8.75332 0 0 0 11.2678 0 10.962 Q28278 PROC_CANLF Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain] PROC Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; proteolysis [GO:0006508] endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] CCGHGSCID;CDCGRGWEGRF;CIDGIGAFHCDCGRGWEG;EIFQNVDDTLAYWSK;IVPICLPDS;LQCQPAVKFPCG;PCCGHGSCIDGIGAFHCDCG 7 13.8 1.0019 -1.4277 0 0 0 10.1946 0 6.83086 0 7.2035 0 7.71184 0 10.2048 0 0 7.76918 Q28289 Q28289_CANLF T-cell-specific surface glycoprotein CD28 CD28 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; regulation of T cell proliferation [GO:0042129] membrane [GO:0016020] FYLRNLFV;LFSKEFRASL 2 10.4 1.003 -0.87186 0 5.55836 0 0 0 0 0 0 0 0 0 0 0 10.1084 0 Q28290 Q28290_CANLF p-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (Leukocyte-endothelial cell adhesion molecule 3) (Platelet activation dependent granule-external membrane protein) GMP140 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155] plasma membrane [GO:0005886] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] NCLHSVEAFQYQSSCHFSCEEGFA;RECGDFDLPQHV 2 4.8 0.98925 -0.21792 0 0 0 0 0 0 0 0 10.3855 0 0 0 0 0 10.7638 Q28293 KCNA2_CANLF Potassium voltage-gated channel subfamily A member 2 (CSMK1) (Voltage-gated potassium channel subunit Kv1.2) KCNA2 Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; neuronal action potential [GO:0019228]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of dopamine secretion [GO:0014059]; sensory perception of pain [GO:0019233] axon [GO:0030424]; axon terminus [GO:0043679]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249] IFFLFIGVILFS;IGYQQSTSFTDPFFI;SLAILRVIRLVRVFRI;SLAILRVIRLVRVFRIFKLSRHSK;TFHTYSNSTIGY 5 12 0.99214 -0.14056 0 0 0 0 0 0 0 0 0 0 0 8.90361 9.50235 0 0 Q28300 GNAT1_CANLF Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) GNAT1 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; detection of light stimulus involved in visual perception [GO:0050908]; phototransduction, visible light [GO:0007603]; response to light stimulus [GO:0009416]" cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750] G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872] DSARQDDARKLMH;TDIIIKENLKDC 2 7.1 0.98891 -0.2642 0 0 0 7.83029 0 0 0 0 0 0 0 0 0 0 0 Q28309 AA3R_CANLF Adenosine receptor A3 ADORA3 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled adenosine receptor signaling pathway [GO:0001973]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285] dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled adenosine receptor activity [GO:0001609] FYVIRNKLNQNFSS;TTTFYFIVSL 2 7.6 0.99211 -0.5505 0 0 0 7.27146 0 0 0 0 0 0 0 0 0 10.2695 0 Q28343 PGCA_CANLF Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; positive regulation of neuroblast proliferation [GO:0002052]; skeletal system development [GO:0001501] extracellular space [GO:0005615]; perineuronal net [GO:0072534]; synapse [GO:0045202] calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540] GPEVSASGVEDLSGLPSGEGLE;GVEDLSGLPSGEGPETSTSG;GVGDLSGL;GVGDLSGLPSGREGL;PSETYDVYCYVDKL;PSGTDESAPAIPDI;SVELSGLPSGEV 7 7.8 1.0033 -1.5534 8.09059 9.73711 0 0 0 0 0 0 0 10.0693 7.93062 11.3541 0 0 9.85594 Q28346 RL4_CANLF Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) RPL4 RPL1 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GVPGKKPRRKKGKKTVGVKKP;GVPGKKPRRKKGKKTVGVKKPK;GVPGKKPRRKKGKKTVGVKKPKKP;KEAVLLLKKLK;KLRMDKAAAALEAKSEEKG;PGKKPRRKKGKKT;RKKGKKTVGVKKPKKPV;VLKKNPLKNLRIMLKLNP 8 17.1 0.99339 -0.062496 0 5.46875 0 3.073 0 0 0 0 0 0 0 4.80869 6.70446 0 0 Q28350 MYC_CANLF Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular iron ion homeostasis [GO:0006879]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to gamma radiation [GO:0010332]; response to xenobiotic stimulus [GO:0009410] cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CDEEENFYQQQQQS;SAESSPRASPEPLALH;YFYCDEEENFYQQ 3 7.3 0.99435 -0.12224 0 0 0 0 0 6.32254 0 6.08128 0 0 0 0 0 0 0 Q28874 Q28874_CANLF Tissue factor pathway inhibitor TFPI Canis lupus familiaris (Dog) (Canis familiaris) cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of blood coagulation [GO:0030195] caveola [GO:0005901]; cell surface [GO:0009986]; extracellular space [GO:0005615] serine-type endopeptidase inhibitor activity [GO:0004867] DSGDSMPPDSEIGGLQHDSESGGLQ;ISKGGLIKTKRKRK;KTKRKRKKQTVKIVY 3 11.9 0.85088 0.15018 0 3.63645 0 4.46035 0 0 0 0 4.57864 0 0 0 6.43601 0 0 Q29416 IL2_CANLF Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-2 receptor binding [GO:0005134] CEYDDETATITEFLNK 1 10.3 0.9618 0.049233 9.37374 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q29475 Q29475_CANLF Cellular tumor antigen p53 p53 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; protein tetramerization [GO:0051262]; rhythmic process [GO:0048511] centrosome [GO:0005813]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; PML body [GO:0016605] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" CNSSCMGG;SPPQKKKPLDGEYFTLQI;SVTWTYSPLLNKLFC;VGSDYTTIHYNYMCNSSCM 4 19.2 1.0025 -1.1853 0 10.6755 0 0 0 0 0 10.1669 0 4.87907 5.70976 0 0 0 0 Q29476 ST1A1_CANLF Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase) (Phenol sulfotransferase) (Phenol-sulfating phenol sulfotransferase) (P-PST) SULT1A1 Canis lupus familiaris (Dog) (Canis familiaris) catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403] cytoplasm [GO:0005737]; cytosol [GO:0005829] 3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; aryl sulfotransferase activity [GO:0004062] FMAGEVSY;LSHTHPVLYLFYED;VAVSYYHFYRM;VGRSLPEETVDLIVQH 4 16.6 1.0024 -0.95872 11.1978 0 0 0 6.82731 0 0 0 0 0 0 0 0 9.8612 0 Q29536 KPYR_CANLF Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase isozymes L/R) PKLR Canis lupus familiaris (Dog) (Canis familiaris) cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096] cytoplasm [GO:0005737] ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] LEVSDGIMVARGDLGI;MLESMITKPRPT 2 4.9 0.99094 -0.13553 0 0 0 0 9.51325 0 0 0 0 0 0 6.49028 0 0 0 Q29611 CLN3_CANLF Battenin (Protein CLN3) CLN3 Canis lupus familiaris (Dog) (Canis familiaris) "amyloid precursor protein catabolic process [GO:0042987]; autophagosome-lysosome fusion [GO:0061909]; glycerophospholipid biosynthetic process [GO:0046474]; glycolipid transport [GO:0046836]; Golgi to lysosome transport [GO:0090160]; intracellular water homeostasis [GO:0009992]; L-arginine transmembrane transport [GO:1903826]; learning or memory [GO:0007611]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; negative regulation of apoptotic process [GO:0043066]; phagosome-lysosome docking [GO:0090384]; phagosome-lysosome fusion [GO:0090385]; plasma membrane raft organization [GO:0044857]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of pinocytosis [GO:0048549]; receptor-mediated endocytosis [GO:0006898]; regulation of arginine biosynthetic process [GO:1900079]; regulation of autophagosome maturation [GO:1901096]; regulation of cellular response to osmotic stress [GO:0106049]; regulation of cytoskeleton organization [GO:0051493]; regulation of fibroblast migration [GO:0010762]; regulation of modification of synaptic structure [GO:1905244]; regulation of phagosome maturation [GO:1905162]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein processing [GO:0070613]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal potassium excretion [GO:0036359]; vesicle transport along microtubule [GO:0047496]" autolysosome [GO:0044754]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802] glycolipid binding [GO:0051861]; sulfatide binding [GO:0120146] GNQSHVDPDP;LLFFRNTSLNHAQQYRWYQML;STAAVLLADILPTLIIKLLAPLGL;VGEVTFLSLTAFYP;YRWYQMLYQAGVF 5 17.1 0.98779 -0.46093 0 0 0 0 0 0 4.49889 0 9.40729 0 0 0 6.90761 0 0 Q2A652 Q2A652_CANLF G-protein coupled receptor (Prostaglandin D2 receptor 2) PTGDR2 crth2 Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; prostaglandin D receptor activity [GO:0004956] ARSRSQDERGPL;GLILFVVGCRMR;LVAFVVPLAIIA 3 9 1.0029 -0.85531 0 0 0 0 0 0 0 0 0 0 0 9.37152 0 0 12.8496 Q2AB25 Q2AB25_CANLF Pepsinogen B isozyme PgnB Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190] LGYDTVTVQNIVI;TFPLTVPQQYLDSFVKATGAQ 2 9.1 0.98441 -0.24008 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.5482 Q2ABC6 Q2ABC6_CANLF Taste receptor type 2 CAFA-T2R67 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] DSLLMVFWQ;FTNFWVNLYQRHERN;WLRWRISRVLLVL 3 11.9 0.99077 -0.13529 4.90569 0 0 7.09761 6.62306 0 0 12.1619 6.80684 0 12.2287 0 5.65326 7.10203 0 Q2ABC7 Q2ABC7_CANLF Taste receptor type 2 TAS2R42 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] VVLAILVFSLFFL 1 4 0.93819 0.059582 0 0 0 0 0 0 0 0 0 0 6.99921 0 0 0 0 Q2ABC9 Q2ABC9_CANLF Taste receptor type 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] LSVPCSVF 1 2.6 1.0037 -1.1044 0 0 0 0 5.01685 0 8.64987 0 8.37186 0 0 0 0 0 0 Q2ABD0 Q2ABD0_CANLF Taste receptor type 2 TAS2R40 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] WNILCKIVMAAY 1 3.9 0.95222 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 3.93319 0 0 Q2ABD1 Q2ABD1_CANLF Taste receptor type 2 TAS2R39 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] FSHPLFLKLKW;PLFLKLKWRISRLM 2 5.3 0.92842 0.096448 0 0 0 0 0 0 4.52023 5.99202 0 0 0 0 0 0 0 Q2ABD2 Q2ABD2_CANLF Taste receptor type 2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] LSLSLTRLFLHGLLFLDAIQLTY 1 7.3 0.97832 0.046253 0 3.76967 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2ABD3 Q2ABD3_CANLF Taste receptor type 2 CAFA-T2R12 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] DLITEAHVRAMKFMISFLLFFFIYY;FSYPSGHPFL;IFFWLKRRIHRLLLIIVLG;KRRIHRLLLII;KRRIHRLLLIIV;TESNVTLNFTARKY 6 21.7 0.98768 -0.35065 4.12813 0 0 0 0 0 0 0 11.3975 5.18761 0 0 6.40948 0 0 Q2ABD5 Q2ABD5_CANLF Taste receptor type 2 TAS2R7 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] FWTLTNHLSVWFA 1 4.2 0.94313 0.059878 0 10.2052 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2ABD6 Q2ABD6_CANLF Taste receptor type 2 TAS2R5 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] EHPVCLWLKQRAYCLSL;IVSLYRHHKKMEVH;VLGLAVCRFLLQ;VSLYRHHKK 4 14.6 1.0015 -0.69896 8.84241 8.58864 0 0 0 0 0 8.08247 6.11545 0 0 0 0 6.90725 0 Q2ABD7 Q2ABD7_CANLF Bitter taste receptor Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] GVFLLLKRNLSPKI;KLKTKAKKIL 2 11.5 0.99188 -0.55069 4.97842 0 0 0 0 0 4.05511 0 0 0 0 0 0 0 0 Q2ABD9 Q2ABD9_CANLF Taste receptor type 2 CAFA-T2R2 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] LLVNLALLFPLAIFVMC 1 5.6 0.97667 0.046227 0 5.92236 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2ABE0 Q2ABE0_CANLF Taste receptor type 2 TAS2R1 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580] membrane [GO:0016020] bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930] RLLLPLLIFL 1 3.4 0.99957 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.316 Q2HNR1 Q2HNR1_CANLF Collagen type X alpha 1 COL10A1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; extracellular region [GO:0005576] VGPAGHPG;YTKGYLDQ 2 2.6 1.0032 -1.6146 0 0 9.06399 0 0 0 0 0 0 0 0 0 0 0 0 Q2KM13 Q2KM13_CANLF Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 Canis lupus familiaris (Dog) (Canis familiaris) antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of chemokine production [GO:0032722]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; response to interferon-alpha [GO:0035455] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743] HYRSCWAGEDYNPEDSVNP 1 3.6 0.95264 0.04981 8.87338 0 0 0 0 0 0 0 0 0 8.76636 0 0 0 0 Q2L4T3 Q2L4T3_CANLF Toll-like receptor 7 protein TLR7 Canis lupus familiaris (Dog) (Canis familiaris) activation of innate immune response [GO:0002218]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of type II interferon production [GO:0032729]; regulation of primary metabolic process [GO:0080090]; signal transduction [GO:0007165] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335] double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197] EYARSCRFKNKETPSFLPF;FRGNHLDVLWRDGDNRYLKFFKN;TMESESLKILEFRGNHLD 3 5 0.99225 -0.18067 0 0 0 0 0 0 9.46897 0 0 0 0 0 9.74531 11.9974 0 Q2QB47 Q2QB47_CANLF aldehyde oxidase (EC 1.2.3.1) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; NAD binding [GO:0051287]" EAFEKVDQIVEG;GPDEYKIPTITD;GTGKCCLDPGGNDSSSV;HYPEIPDGFLSALEDFPITGPQGVQ;ISVEGARQ;LTGAHKKIRTD;RQMPLNERFLAGLASADLKPEE 7 7.8 1.0029 -0.97646 0 0 0 6.0054 7.36045 7.27687 10.1778 0 0 0 0 0 0 13.3157 13.4803 Q2QB48 Q2QB48_CANLF aldehyde oxidase (EC 1.2.3.1) Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737] "2 iron, 2 sulfur cluster binding [GO:0051537]; aldehyde oxidase activity [GO:0004031]; FAD binding [GO:0071949]; iron ion binding [GO:0005506]; NAD binding [GO:0051287]" EKTKTYSALLKH;GGGCGACT;ITAEDVPGSNNHR;KTYSALLKHL;KYSCGGGGCGA;NLQMFYGSVDSTVV;RVTLVHSRNPIA;VIRKNPKG 8 5.5 0.98384 -0.25656 0 0 0 0 0 0 0 11.2425 0 0 0 0 0 0 0 Q2THW9 ZDHC5_CANLF Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) ZDHHC5 Canis lupus familiaris (Dog) (Canis familiaris) innate immune response [GO:0045087]; lipid transport [GO:0006869]; positive regulation of pyroptotic inflammatory response [GO:0140639] intracellular organelle [GO:0043229]; plasma membrane [GO:0005886] palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706] FTCPGLSLCVS;GTGFELGQLQSIRSEGT;PTSIAESSRHPSYR 3 5.9 0.99457 -0.15663 0 0 0 0 0 0 9.26287 0 0 0 0 0 0 0 8.03925 Q2V0Q7 Q2V0Q7_CANLF Chemokine (C-C motif) receptor 1 CCR1 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of monocyte chemotaxis [GO:0090026] membrane [GO:0016020] C-C chemokine receptor activity [GO:0016493] LTVLVSAFQDSLF;VSAFQDSLFTDECRQSKQL 2 6.5 0.91877 0.11732 0 0 0 0 0 0 6.31096 0 0 0 0 0 5.49461 0 0 Q2VCE2 Q2VCE2_CANLF Multifunctional fusion protein [Includes: Interleukin-1; Interleukin-1 beta] IL1B Canis lupus familiaris (Dog) (Canis familiaris) fever generation [GO:0001660]; immune response [GO:0006955]; positive regulation of cell division [GO:0051781] cytosol [GO:0005829]; extracellular space [GO:0005615]; lysosome [GO:0005764] cytokine activity [GO:0005125]; interleukin-1 receptor binding [GO:0005149] FHMSFVHGDESN;MAAVPELTSEMMAYSSNNEN;PELTSEMMAYSSNNENDLFF;QDISHKYLVLSNSYE 4 19.2 0.98834 -0.3447 0 0 0 0 0 9.04849 0 0 10.4747 4.58856 0 0 0 7.4847 0 Q2WCD8 Q2WCD8_CANLF MHC class II antigen DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] TELGRPSAESWNGQK;VGEYRAVT 2 24.7 0.93682 0.072918 0 0 0 9.74414 0 0 0 0 0 0 0 0 0 0 0 Q2Z1P8 Q2Z1P8_CANLF Anion exchange protein SLC4A1 Canis lupus familiaris (Dog) (Canis familiaris) bicarbonate transport [GO:0015701]; blood coagulation [GO:0007596]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; erythrocyte development [GO:0048821]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of urine volume [GO:0035811]; pH elevation [GO:0045852]; plasma membrane phospholipid scrambling [GO:0017121]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular pH [GO:0051453]; transmembrane transport [GO:0055085] ankyrin-1 complex [GO:0170014]; basolateral plasma membrane [GO:0016323]; cortical cytoskeleton [GO:0030863]; cytoplasmic side of plasma membrane [GO:0009898]; plasma membrane [GO:0005886]; Z disc [GO:0030018] ankyrin binding [GO:0030506]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; hemoglobin binding [GO:0030492]; protein homodimerization activity [GO:0042803]; solute:inorganic anion antiporter activity [GO:0005452] AALSPAITFGGLLGE;EEQIRPQDRDLLLRVL;LILTVPLRRLLLPLIFRKL;LLLRVLLLKH;LLRVLLLKH;LTVPLRRLLLPLIFRKL;LVGRAAFLERPVLGFVRL;PLRRLLLPLIFRKLE;VPLRRLLLPL 9 7.8 0.97094 0.048313 0 0 0 0 0 0 0 0 0 9.72554 0 8.9969 0 0 0 Q307K7 Q307K7_CANLF Cytochrome P450 (EC 1.14.14.1) CYP2A25 CYP2A7 Canis lupus familiaris (Dog) (Canis familiaris) endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" VRRQWKLLEKLPP 1 2.6 0.93862 0.059702 0 0 0 0 0 8.20858 0 0 9.83584 0 0 0 0 0 0 Q30DN6 KDM5D_CANLF Lysine-specific demethylase 5D (EC 1.14.11.67) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) KDM5D JARID1D SMCY Canis lupus familiaris (Dog) (Canis familiaris) chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355] chromatin [GO:0000785]; nucleus [GO:0005634] DNA binding [GO:0003677]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; metal ion binding [GO:0046872] EEVMKRLTPELFDSQ;GVDVPEAHQLQ;HYRRLRRYCVFSHEELICKMAAF;LLEVTLDENHR;LLTIAERWEEKA;VMKRLTPELFDSQP;WYGVPSLAAEQLE;WYGVPSLAAEQLEEV;YHSGFNQGYNFAEAVNFC 9 6.7 1.0018 -0.96198 0 10.2324 15.6293 12.3628 0 0 9.23266 11.0821 14.0543 0 11.0978 9.67097 0 0 8.93375 Q30KR2 Q30KR2_CANLF Sperm-associated antigen 11 variant E SPAG11 SPAG11E Canis lupus familiaris (Dog) (Canis familiaris) antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1 beta production [GO:0032691] cell surface [GO:0009986]; extracellular space [GO:0005615] PGIRDVICLTQH;STEAEIKNKPET 2 28.9 0.98679 -0.45915 0 0 12.9969 11.2268 0 0 0 0 0 0 0 0 0 0 0 Q30KR3 Q30KR3_CANLF Sperm associated antigen 11B (Sperm-associated antigen 11 variant C) SPAG11 SPAG11B Canis lupus familiaris (Dog) (Canis familiaris) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844] extracellular region [GO:0005576] EGYCQEYCNYME 1 10.3 0.95667 0.05044 0 0 0 0 0 0 7.78326 0 0 0 0 0 0 0 0 Q30KS4 Q30KS4_CANLF Beta-defensin 130 CBD130 Canis lupus familiaris (Dog) (Canis familiaris) cell chemotaxis [GO:0060326]; defense response to bacterium [GO:0042742] extracellular space [GO:0005615] CCR6 chemokine receptor binding [GO:0031731]; chemoattractant activity [GO:0042056] ATPAPKAK 1 10.1 1.0031 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.41439 0 Q30KS5 Q30KS5_CANLF Beta-defensin 129 CBD129 Canis lupus familiaris (Dog) (Canis familiaris) FASLMLQYQ 1 5.4 1.0044 -0.80421 0 0 0 0 0 0 0 0 0 0 0 8.93012 0 0 0 Q30KT9 Q30KT9_CANLF Beta-defensin CBD114 Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; innate immune response [GO:0045087] extracellular region [GO:0005576] YYLLHFLCYVTFI 1 19.4 0.93693 0.072428 0 0 0 0 4.57119 0 0 0 0 0 3.56499 0 0 0 0 Q32KH0 ARSK_CANLF Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) ARSK Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576]; lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; glucuronate-2-sulfatase activity [GO:0015024]; metal ion binding [GO:0046872] FIKWKQSVGQNYS 1 2.4 0.99193 -0.20811 0 0 9.65971 0 0 0 0 0 4.27493 0 4.65581 0 0 0 0 Q32KH1 Q32KH1_CANLF Extracellular sulfatase (EC 3.1.6.-) sulf2 SULF2 Canis lupus familiaris (Dog) (Canis familiaris) bone development [GO:0060348]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611] cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886] arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; N-acetylglucosamine-6-sulfatase activity [GO:0008449] DKVWLLREQKRKKKLRKLLK;KKKLRKLLKRL;KRKKKLRKLLKRLQ;KVWLLREQKRKKKLRKLLKRLQNND;MLVETGELDNTYIVYTAD;NIILVLTDDQDVELGSMQVMN;QKRKKKLRKLLKRL;REQKRKKKLRKLLKRLQ;RKKKLRKLLKRL;RKKKLRKLLKRLQ;RKKKLRKLLKRLQN;SLHPFRKG;SYEQYRQFQRRK 13 9.8 0.98735 -0.49824 7.38517 5.39726 6.5684 0 7.99865 6.15348 6.71081 0 6.56653 0 8.42391 0 0 7.34678 9.1372 Q32KH5 GALNS_CANLF N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) GALNS Canis lupus familiaris (Dog) (Canis familiaris) lysosome [GO:0005764] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890] AGLAPPSDRVID;AGRVSHQLGSI;LTPPESTPKKCSWPH;VLSAAGLGAAGAP;VTTHTQEEHTKL 5 12.1 1.0021 -0.68645 0 0 0 0 9.02569 0 10.3046 0 0 0 0 0 0 0 8.93269 Q32KI2 Q32KI2_CANLF Arylsulfatase D (EC 3.1.6.1) arsd Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] arylsulfatase activity [GO:0004065] GDNVEEMDWLVGE 1 2.2 0.98888 -0.26498 0 0 0 0 0 0 0 0 0 0 8.56228 0 0 0 0 Q32KI4 Q32KI4_CANLF Arylsulfatase B (EC 3.1.6.12) arsb ARSB Canis lupus familiaris (Dog) (Canis familiaris) colon epithelial cell migration [GO:0061580]; regulation of epithelial cell migration [GO:0010632] N-acetylgalactosamine-4-sulfatase activity [GO:0003943] ALNVTRCALDFRDGE;GVLRLLLRLL;GVLRLLLRLLL;GVLRLLLRLLLL;GVLRLLLRLLLLLA;GVLRLLLRLLLLLAPP;GVLRLLLRLLLLLAPPG;GVLRLLLRLLLLLAPPGA;GVLRLLLRLLLLLAPPGAGARAAG;IHDKNRRYYAGMV;LLAPPGAG;LRLLLRLLLLLAPP;PGVLRLLLRLLLLL;PRLPGVLRLLLRLLL;PSQHNVSVIPSSDP;PTRRGFDT;RLLLRLLLLLAPPG;RLPGVLRLLLRLLLLL;RLPGVLRLLLRLLLLLAPPGA;RPRLPGVLRLLLRLLLLLAP;RRPRLPGVLRLLLRLLLLL;TRRGFDTYFGYL;VLRLLLRLLL;VLRLLLRLLLLL;VLRLLLRLLLLLA;YFPAQDPRCDP 26 17.9 1.002 -1.2794 9.43819 4.77368 8.7829 6.40552 7.2115 5.68459 7.42727 8.07644 0 0 8.63615 5.02702 8.57561 11.4159 8.85555 Q38IV1 Q38IV1_CANLF E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) BIRC4 XIAP Canis lupus familiaris (Dog) (Canis familiaris) defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neuron apoptotic process [GO:0051402]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type I interferon production [GO:0032481]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; regulation of cell cycle [GO:0051726] cytoplasm [GO:0005737]; nucleus [GO:0005634] cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; endopeptidase regulator activity [GO:0061135]; identical protein binding [GO:0042802]; protein serine/threonine kinase binding [GO:0120283]; ubiquitin protein ligase activity [GO:0061630] AAQPTNPGIQNGQ;AGFYSLGDGDKVKCFHCGG;EISAEEQLRLLQEEKLCKICMDRNI;ERTRSLTERIEDAIF;IVTFRMWMCSIN;VGRHRKVSPN 6 19.1 1.002 -0.67277 0 10.9672 9.37371 0 0 8.0242 0 0 0 0 0 0 8.84081 0 0 Q38J75 Q38J75_CANLF Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596]; proteolysis [GO:0006508] extracellular region [GO:0005576] calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252] LDRGATAL;TDKKDQLICMNE;VGGKVCPKGECPWQ;YTDHVVPLCLPEKTF 4 11 0.95571 0.05044 0 0 0 0 0 0 0 0 0 0 0 7.98709 0 0 0 Q38JA8 Q38JA8_CANLF Baculoviral IAP repeat-containing 2 BIRC2 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981] EQLRRLQEERTCKVCMDK;FSCELYRMSTYS;KNISAMRNSFTHSISPTLEH;VGRNDDVKCFCCDG 4 10.7 0.99441 -0.12885 0 0 0 8.27771 0 0 0 0 0 0 6.49748 0 0 0 0 Q38JA9 Q38JA9_CANLF Caspase 8 CASP8 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein maturation [GO:0051604]; proteolysis involved in protein catabolic process [GO:0051603]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; ripoptosome [GO:0097342] cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; death effector domain binding [GO:0035877]; identical protein binding [GO:0042802]; scaffold protein binding [GO:0097110]; ubiquitin protein ligase binding [GO:0031625] LQRSLDEISNDMSQLPIREG 1 4.1 0.9636 0.048688 0 0 8.69108 0 0 0 0 0 0 0 0 0 0 0 0 Q3C2E2 CD20_CANLF B-lymphocyte antigen CD20 (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) MS4A1 CD20 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; cell surface receptor signaling pathway [GO:0007166] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] ESKTLGAVQI;VLLAAEEKKEQPIETTEEMVELT 2 11.1 1.0031 -0.85944 0 0 0 0 0 0 7.69042 13.4493 0 0 0 0 0 11.5337 0 Q3HR32 Q3HR32_CANLF Endoglycan Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] GASASFPL;IILNMTENIDCEVFRQH;PSLNGGGA;VICKDWSNLAGKNYIILNMTE;VLPRHGSGRHGDWHISLS 5 11.2 1.0028 -1.3855 0 0 0 9.66772 0 0 0 10.6309 8.14883 0 0 0 0 0 0 Q3HTT3 Q3HTT3_CANLF Osteopontin Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; osteoblast differentiation [GO:0001649]; positive regulation of bone resorption [GO:0045780] extracellular space [GO:0005615] extracellular matrix binding [GO:0050840] SQSHEKELIVDSKSEEEDKHLKFH 1 9 0.97436 0.041303 0 0 0 7.50716 0 0 0 0 0 0 0 0 0 0 0 Q3HTU4 Q3HTU4_CANLF Interleukin 27 receptor Canis lupus familiaris (Dog) (Canis familiaris) SSNCCNHSN 1 1.9 1.0035 -0.80421 0 0 0 0 5.00702 0 0 0 0 0 0 0 0 0 0 Q3LSL6 CXCR4_CANLF C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (CD antigen CD184) CXCR4 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; cellular response to cytokine stimulus [GO:0071345]; CXCL12-activated CXCR4 signaling pathway [GO:0038160]; immune response [GO:0006955]; neurogenesis [GO:0022008]; positive regulation of cytosolic calcium ion concentration [GO:0007204] anchoring junction [GO:0070161]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C motif chemokine 12 receptor activity [GO:0038147] SKLSHSKGYQKRKAL;VGNGLVIL;WLVVFQFQHIMV 3 9.9 1.0024 -1.0001 6.69905 0 0 3.34213 0 0 0 0 0 0 0 8.43409 0 0 10.2516 Q3ZKN1 CATK_CANLF Cathepsin K (EC 3.4.22.38) CTSK Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324]; extracellular space [GO:0005615]; lysosome [GO:0005764] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197] EVVQKMTG 1 2.4 1.004 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 6.88777 0 Q45FN0 Q45FN0_CANLF Prostaglandin F2-alpha receptor (Prostanoid FP receptor) PTGFR Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin D stimulus [GO:0071799]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886] prostaglandin F receptor activity [GO:0004958] VYILLRKAVLKNLYKLARR 1 5.2 0.95431 0.04941 0 0 0 0 0 0 0 8.34252 0 0 0 0 0 0 0 Q45KI9 Q45KI9_CANLF BCL2 associated agonist of cell death (Bcl2-associated death promoter) BAD Canis lupus familiaris (Dog) (Canis familiaris) ADP metabolic process [GO:0046031]; ATP metabolic process [GO:0046034]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902220]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; type B pancreatic cell proliferation [GO:0044342] BAD-BCL-2 complex [GO:0097138]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; phospholipid binding [GO:0005543]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903] IQSWWDRNLGRGG 1 7.8 0.93971 0.05983 0 0 0 0 0 0 0 0 0 0 0 0 0 7.14384 7.20271 Q49HH9 TS1R3_CANLF Taste receptor type 1 member 3 (Sweet taste receptor T1R3) TAS1R3 T1R3 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] DLKLWVWRDLKPELRTVGA;LGLVLVALGLFIRHRDSP;NGRLKVWH;VGSDDEYGRQ;VLGGLFPLGT;VLLILLALALGLVLV;VLLILLALALGLVLVALGL;VLVLLILLALALGLVLVALGLF 8 9 0.99876 -0.61022 0 0 0 0 4.84217 5.20875 0 11.0896 5.86466 6.04904 0 0 0 0 10.6971 Q49LX5 SSR1_CANLF Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) SSTR1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to estradiol stimulus [GO:0071392]; neuropeptide signaling pathway [GO:0007218] neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] DNAAEEPVDYYAT;GEGGGSRG;PAQRWLVGF;VGLCGNSMVIYVILRY 4 11.8 1.0038 -1.6798 0 12.3355 0 0 0 0 0 0 0 15.094 0 0 0 9.43325 0 Q49LX6 SSR2_CANLF Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) SSTR2 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; neuropeptide signaling pathway [GO:0007218] cytoplasm [GO:0005737]; neuron projection [GO:0043005]; plasma membrane [GO:0005886] neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994] ESGTWYTGFIIYTFI;VGSSKRKK 2 6.2 1.0048 -1.0505 5.15599 0 0 8.33758 0 0 0 0 0 0 0 0 0 0 0 Q4GX48 Q4GX48_CANLF Macrophage migration inhibitory factor (EC 5.3.2.1) (EC 5.3.3.12) (L-dopachrome isomerase) (L-dopachrome tautomerase) (Phenylpyruvate tautomerase) mif Canis lupus familiaris (Dog) (Canis familiaris) extracellular space [GO:0005615] cytokine activity [GO:0005125]; phenylpyruvate tautomerase activity [GO:0050178] GLLSELTQQLAQA 1 21.7 0.93955 0.059836 0 0 0 0 0 0 0 10.0494 0 0 0 0 0 0 0 Q4JIV8 Q4JIV8_CANLF Melanocortin receptor 4 MC4R Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; feeding behavior [GO:0007631]; insulin secretion [GO:0030073]; positive regulation of bone resorption [GO:0045780]; regulation of eating behavior [GO:1903998]; regulation of metabolic process [GO:0019222]; response to insulin [GO:0032868]; response to melanocyte-stimulating hormone [GO:1990680] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] melanocyte-stimulating hormone receptor activity [GO:0004980]; neuropeptide binding [GO:0042923]; ubiquitin protein ligase binding [GO:0031625] GANMKGAITLT;YPLGGLCDLSSR 2 6.9 0.99456 -0.15545 9.06754 0 0 0 0 0 0 0 0 0 0 19.8964 0 0 0 Q4PPC4 SCN1B_CANLF Sodium channel regulatory subunit beta-1 SCN1B Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell action potential involved in contraction [GO:0086002]; positive regulation of voltage-gated sodium channel activity [GO:1905152]; regulation of heart rate by cardiac conduction [GO:0086091] axon [GO:0030424]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] sodium channel activity [GO:0005272]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325] GCVEVDSETEAVYGMTFKILCI;IVSEIMMYV;LVVGAALVSSAWGGCVEVDSET 3 20.2 0.99327 -0.1624 0 0 8.29737 7.44294 0 0 0 0 0 0 0 6.01308 0 0 8.79529 Q4QYC8 Q4QYC8_CANLF Interleukin 12 receptor beta-2 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] EEEPTGTLDVWYMK;ILHYRIYWKEQDSN;LRPQWCSKEIPDPANSTWAKKYP;TLQLNGPKNLTWWKQC 4 7.8 0.80563 0.21738 0 0 9.28059 0 0 0 0 10.2892 0 9.14203 0 0 7.75616 0 7.75489 Q4U3Q4 PPARG_CANLF Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cellular response to insulin stimulus [GO:0032869]; fatty acid metabolic process [GO:0006631]; hormone-mediated signaling pathway [GO:0009755]; macrophage derived foam cell differentiation [GO:0010742]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; rhythmic process [GO:0048511] cytoplasm [GO:0005737]; nucleus [GO:0005634] "chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]" DLRALAKHLYDSYI;GISSVDLSVMDDHSHS;GVHEIIYT;IDQLNPESADLRAL 4 9.3 1.0017 -1.4117 8.61265 8.37243 0 0 0 0 0 9.29533 9.56003 0 0 0 9.95661 10.353 10.45 Q4VYB4 Q4VYB4_CANLF Serine peptidase inhibitor Kazal type 5 (Serine protease inhibitor Kazal-type 5) spink5 SPINK5 Canis lupus familiaris (Dog) (Canis familiaris) epidermal cell differentiation [GO:0009913]; negative regulation of antibacterial peptide production [GO:0002787]; negative regulation of proteolysis [GO:0045861]; regulation of cell adhesion [GO:0030155] cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; epidermal lamellar body [GO:0097209]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471] serine-type endopeptidase inhibitor activity [GO:0004867] AEEKKKAEVEERSKRES;AVQELCSEYRNYVRNGRLPCTREN;DPVRDADGKSYNNKCTMC;EEEKKKKESE;LVCTRENDPVLGSDGKTHG 5 8.3 1.0022 -0.65822 0 10.5546 0 0 0 0 0 6.38659 12.3622 0 0 0 0 0 6.43521 Q56JJ4 Q56JJ4_CANLF Presenilin-2 Canis lupus familiaris (Dog) (Canis familiaris) amyloid precursor protein catabolic process [GO:0042987]; intracellular signal transduction [GO:0035556]; protein processing [GO:0016485] membrane [GO:0016020] "aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]" HVIMLFVPVTLCMIVVV;RPTTWPWTTLP;SPISTSGKCLRPTTWP 3 18.7 0.98941 -0.50866 0 0 0 0 12.2024 0 0 0 0 0 0 0 0 0 0 Q597Q0 Q597Q0_CANLF Collagen type IV alpha 3 chain COL4A3 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; extracellular space [GO:0005615]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020] ETSEPEGQVGAPG;GAMGKPGP;GHSGPAGTEGAPGHP;GPKGVRGI;GSPGPIGLPGYPGPPG;LKGEKGETSEPE;PGHSGPAG;QDLGTLGSCLQRFTTMPFLFCNINN;VGGLPGHV 9 6.1 0.99746 -3.422 0 0 10.6291 9.50002 10.8846 0 0 0 7.09011 0 10.8847 11.9129 0 0 0 Q5F2N4 FUT10_CANLF "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" FUT10 Canis lupus familiaris (Dog) (Canis familiaris) fucosylation [GO:0036065]; N-glycan fucosylation [GO:0036071]; neuronal stem cell division [GO:0036445]; protein glycosylation [GO:0006486] endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; fucosyltransferase activity [GO:0008417] EVLKSLRYLVPLRSKNNLRRRLA;LVYIQSDCDPPS;MEEEPVHLYPLPG;YIQSDCDPPSDRDS 4 10.9 1.0016 -0.75199 0 0 0 0 0 0 6.3044 0 0 0 0 9.67708 0 0 9.68461 Q5I2M8 TLR9_CANLF Toll-like receptor 9 (CD antigen CD289) TLR9 Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell differentiation [GO:0045577]; regulation of primary metabolic process [GO:0080090]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; toll-like receptor signaling pathway [GO:0002224] early phagosome [GO:0032009]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886] pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322] LDNLPKSLRLLRLR;LGTALTRDNRHFYNQ;LSRTNILVLD;RLRDNYLAFFNW 4 4.7 0.98744 -0.35431 0 11.3663 0 0 0 0 0 0 0 4.80121 0 0 0 0 0 Q5I9W4 Q5I9W4_CANLF Protein kinase B Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] IVSALEYLHSRDVV 1 3.6 0.93298 0.060837 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.3265 Q5IFP1 3BHS_CANLF 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B Canis lupus familiaris (Dog) (Canis familiaris) C21-steroid hormone metabolic process [GO:0008207]; hippocampus development [GO:0021766]; response to corticosterone [GO:0051412]; steroid biosynthetic process [GO:0006694] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial membrane [GO:0031966] "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid delta-isomerase activity [GO:0004769]" LPISLEYWLAFL;SVQGQFYYISDDTPHQSYDD;VIHTASVIDVMNVI 4 14.2 0.98644 -0.45609 12.0063 0 0 0 11.7189 9.882 0 0 0 0 0 0 12.2959 0 0 Q5J2F2 Q5J2F2_CANLF Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) NKX2.5 NKX2-5 Canis lupus familiaris (Dog) (Canis familiaris) adult heart development [GO:0007512]; atrial septum morphogenesis [GO:0060413]; cardiac conduction system development [GO:0003161]; cell differentiation [GO:0030154]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of neuron differentiation [GO:0045666]; regulation of transcription by RNA polymerase II [GO:0006357]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; ventricular septum morphogenesis [GO:0060412] Nkx-2.5 complex [GO:1990664]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993] "chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" VLVRDGKPCLGDSAPYAPAYGV;VQSPGIPQGNSGVST 2 11.5 0.99147 -0.20605 0 0 9.49476 0 0 0 0 0 10.3117 0 0 0 0 0 0 Q5JCF5 Q5JCF5_CANLF Utrophin Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane bounded cell projection [GO:0120025]; postsynaptic membrane [GO:0045211] actin binding [GO:0003779]; zinc ion binding [GO:0008270] AAEIKGYKK;ELERIIADLEEEQRN;EQMLHQPM;ISELDDANLQVE;KKECEEGEIS;KREKIVKRLISELD;LDQLSEIGQDVGQLVDN;LEQPESDSRINGVSPWASPQ;LLGDLDVEISWAK;LQESLGELDKQLTTYLTDRIDAFQ;LYTLAEETKALEK;PHDTSTDLTEFM;SFAALNRTGEGIVQKLSP;TESSAALQNLIE;TSEGLLGDLDVEISW;VCRWTEERWSRLQEINILWQ;VLKNKFRSKKY;VLQRGEQML;VQRLEDSSNQV 19 7.1 0.99075 -0.26822 0 0 0 0 0 0 0 0 7.99424 0 0 0 0 0 0 Q5JZQ7 CLN8_CANLF Protein CLN8 CLN8 Canis lupus familiaris (Dog) (Canis familiaris) ceramide metabolic process [GO:0006672]; cholesterol metabolic process [GO:0008203]; lipid homeostasis [GO:0055088]; nervous system development [GO:0007399]; phospholipid metabolic process [GO:0006644] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116] ceramide binding [GO:0097001] DGGTSESIFDLDYT;IHMFHCRMVLTYHMWWVCFWHWDGL 2 13.5 0.93042 0.096478 0 0 0 5.94932 0 0 0 0 0 0 6.45353 0 0 0 0 Q5KSK8 CXCR3_CANLF C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) CXCR3 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of leukocyte migration [GO:0002685] external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; C-X-C chemokine binding [GO:0019958]; C-X-C chemokine receptor activity [GO:0016494]; signaling receptor activity [GO:0038023] AVQWVFGSGLCKVAG;VLLVSRGQRRQRRMRLVV 2 9 0.94172 0.10221 0 0 0 6.00047 0 0 0 0 0 0 8.37121 0 0 0 0 Q5KSU7 Q5KSU7_CANLF C-C motif chemokine CCL7 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615] chemokine activity [GO:0008009] RKIPIQKLKSYRRT 1 14.1 0.94063 0.060769 0 0 0 0 0 5.96927 0 0 0 0 0 0 0 0 0 Q5NDE9 PMGT2_CANLF "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" POMGNT2 AGO61 GTDC2 Canis lupus familiaris (Dog) (Canis familiaris) neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363] AQEFQMKTVTVSLEDQA;YVPYILALQNHTFTE 2 5.5 0.92387 0.1084 0 0 0 0 8.58331 0 0 0 0 0 0 0 0 8.83453 0 Q5QQ50 XYLT2_CANLF Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 2) (Xylosyltransferase II) XYLT2 Canis lupus familiaris (Dog) (Canis familiaris) chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] extracellular space [GO:0005615]; Golgi membrane [GO:0000139] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158] GGLSDVMLTAYTAF;LVVWSFSGLEEDEPGEK;TDDPLVAQLRQFYTYTLLPAESF;VGAAGFPPHGDT 4 7.6 0.99444 -0.019064 0 0 0 0 8.89248 0 0 0 0 0 0 0 9.11061 0 0 Q5QQX7 CP19A_CANLF Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) CYP19A1 CYP19 Canis lupus familiaris (Dog) (Canis familiaris) female gonad development [GO:0008585]; lipid metabolic process [GO:0006629]; response to estradiol [GO:0032355] endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789] aromatase activity [GO:0070330]; heme binding [GO:0020037]; iron ion binding [GO:0005506] NNNPTLWKAIRPF 1 2.6 0.93923 0.05983 0 0 0 0 0 0 8.77739 0 0 0 0 0 0 0 0 Q5RL82 Q5RL82_CANLF Leptin receptor LEPR Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] NGFTKDAIDKQQ 1 9.3 0.98963 -0.26403 0 0 1.57633 0 0 0 9.29395 0 0 0 0 0 0 0 0 Q5S825 Q5S825_CANLF Prolactin Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] hormone activity [GO:0005179]; metal ion binding [GO:0046872] PYPVWSGLPSL;QRVHYHGPQQ 2 8.8 0.98733 -0.33804 0 12.8329 0 0 0 0 0 0 0 0 0 0 0 0 9.5091 Q5SBJ1 Q5SBJ1_CANLF DNA polymerase (EC 2.7.7.7) Canis lupus familiaris (Dog) (Canis familiaris) base-excision repair [GO:0006284]; double-strand break repair via nonhomologous end joining [GO:0006303] cytoplasm [GO:0005737]; nucleus [GO:0005634] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872] LTHPSFTSESAKQPKLLHRVVEQL;RRIDIRLIPKDQYY;TKIAEKIDEFL 3 15.4 0.98963 -0.1995 0 8.42882 0 0 0 0 0 0 0 6.31228 0 0 0 0 0 Q5TJE2 ZBT22_CANLF Zinc finger and BTB domain-containing protein 22 (Zinc finger protein 297) ZBTB22 ZNF297 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]" EEQVNFCESSNDFGSYDGGGPG;GERRGGGP;GGGGGGPG;THTGLKPYECGVCAKKFMWRDSFMR;VEMGFGGGGG;VGGGGGGG;VLQMWHIV;VLTCEDDEDEE 8 14.7 1.003 -2.1554 0 0 7.64537 0 7.97894 8.01491 0 0 10.3875 8.39197 8.46189 7.89712 7.79883 8.02259 0 Q5TJE5 RGL2_CANLF Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (Ras-associated protein RAB2L) RGL2 RAB2L Canis lupus familiaris (Dog) (Canis familiaris) small GTPase-mediated signal transduction [GO:0007264] guanyl-nucleotide exchange factor activity [GO:0005085] AAWGEATRDSLRVFSSL;EEEDEAPVSVWDE;VSVWDEEEDGATFTVTSRQ 3 5.5 0.99369 -0.17008 0 0 0 0 0 0 0 0 7.73762 0 0 0 0 8.06064 0 Q5TJE8 B3GT4_CANLF "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3GALT4 Canis lupus familiaris (Dog) (Canis familiaris) lipid metabolic process [GO:0006629]; protein O-linked glycosylation [GO:0006493] Golgi membrane [GO:0000139] "ganglioside galactosyltransferase activity [GO:0047915]; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity [GO:0008499]" CVKLAGATHYPLDR;LSLFRRLLLAALLLVI;PLSLFRRLLLAALLLVIIWTL 3 9.1 0.9893 -0.21635 0 0 0 5.33217 4.97228 0 0 0 0 0 0 0 0 0 0 Q5TJF0 VPS52_CANLF Vacuolar protein sorting-associated protein 52 homolog VPS52 Canis lupus familiaris (Dog) (Canis familiaris) "endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; recycling endosome [GO:0055037] syntaxin binding [GO:0019905] KHLESYLTDCYDAI;MEEEEGPL;VISPTELEAP 3 4.4 0.99415 -0.11807 0 0 3.28861 14.8801 14.884 0 0 9.83635 0 0 0 0 0 0 0 Q5TJF3 RING1_CANLF E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (RING1a) RING1 Canis lupus familiaris (Dog) (Canis familiaris) anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; protein ubiquitination [GO:0016567] cytosol [GO:0005829]; nuclear speck [GO:0016607]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151] chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activator activity [GO:0097027] GEGEPGEGEGDG;GGPGGGASDAGGPDGGGGEGG;VGTGGGGA;VGTGGGGAG 4 10.3 0.98596 -0.43359 0 0 0 12.1907 0 4.08831 0 11.7071 0 0 0 0 0 0 0 Q5TJF8 Q5TJF8_CANLF Retinoid X receptor beta RXRB RXRB-006 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384] nucleus [GO:0005634] nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; retinoic acid-responsive element binding [GO:0044323]; zinc ion binding [GO:0008270] VEVLREKVYASLETY;VISSSMGSPGL 2 5.7 0.99442 -0.12947 0 0 0 0 7.79207 0 0 0 0 0 0 0 0 0 0 Q5TJG5 Q5TJG5_CANLF "HLA class II histocompatibility antigen, DO alpha chain-like (MHC class II antigen DO alpha)" DLA-DOA DLA-DOA-001 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; negative regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002587]; peptide antigen assembly with MHC class II protein complex [GO:0002503]; positive regulation of immune response [GO:0050778]; positive regulation of T cell activation [GO:0050870]; regulation of T cell differentiation [GO:0045580] collagen trimer [GO:0005581]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; MHC class II protein complex [GO:0042613] MHC class II protein complex binding [GO:0023026]; peptide antigen binding [GO:0042605] RQAVWRLPEFGNLAHF 1 6.4 0.95588 0.049233 0 0 0 0 0 8.96258 0 0 0 0 0 4.99752 0 0 0 Q5TJG9 Q5TJG9_CANLF "MHC class II antigen DM alpha (Major histocompatibility complex, class II, DM alpha)" DLA-DMA DLA-DMA-004 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581]; membrane [GO:0016020] LVLIVYFRK 1 5.3 1.004 -0.80421 0 0 0 0 0 0 0 0 4.58478 0 0 0 0 0 0 Q5U9C9 Q5U9C9_CANLF Sodium-glucose cotransporter-like 2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] glucose:sodium symporter activity [GO:0005412] EDISEDPSWARVVN;EVCKRVCGTE;GLAVAGFEWNALF;RTNRGTVGGYFLAGRSMVWWPVG 4 8.9 0.9847 -0.25493 9.81935 0 0 0 0 0 7.74678 0 0 0 0 0 0 0 8.84627 Q5W415 Q5W415_CANLF "Proteasome (Prosome, macropain) subunit, beta type, 8 (Large multifunctional protease 7)" PSMB8 PSMB8-001 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis involved in protein catabolic process [GO:0051603] cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839] peptidase activity [GO:0008233] RLLAKECRLYYLRNGE 1 6.3 0.98534 -0.25319 0 0 0 0 0 0 0 0 0 0 0 0 11.2016 0 0 Q5W7P8 TRBM_CANLF Thrombomodulin (TM) (CD antigen CD141) THBD Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] membrane [GO:0016020] calcium ion binding [GO:0005509]; transmembrane signaling receptor activity [GO:0004888] DVDDCIQVPSL;EEQRCAAEAD;GSKCEYQCQPVSQTDY;IDECENGECP;LVDNECVEPVDP;SLCPQLCVNTRGAFECHCYPGY 6 13.7 1.0025 -1.3554 0 0 0 0 0 0 0 4.36877 6.02181 0 0 0 0 8.27873 0 Q5WR07 TNFB_CANLF Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1) LTA TNFB TNFSF1 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955] extracellular space [GO:0005615]; membrane [GO:0016020] cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164] EVQLFSSQ;QGFPGVGIS 2 8.3 1.003 -1.9086 0 0 0 7.59328 0 0 8.92923 0 0 8.17842 0 0 0 0 0 Q5WR08 Q5WR08_CANLF NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) NFKBIL1 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to lipopolysaccharide [GO:0071222]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720] nucleoplasm [GO:0005654]; nucleus [GO:0005634] transcription regulator inhibitor activity [GO:0140416] APAGEAST;QRLFRERARAK;WGPPWDSAEEEEE 3 8.4 0.99221 -0.17087 0 0 0 0 0 7.49729 0 0 0 0 10.2275 0 6.43371 0 0 Q5XWD5 IF_CANLF Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF) (Pancreatic intrinsic factor) CBLIF GIF Canis lupus familiaris (Dog) (Canis familiaris) cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] extracellular space [GO:0005615] cobalamin binding [GO:0031419] IPEGSEEGYRTLFSQVLK;SVKDGSVLLVVLEEAQRRNPMFK;TIMALNSSCR 3 12.2 0.98757 -0.47864 9.4041 0 10.2701 0 0 0 0 9.73395 0 0 0 0 0 0 0 Q60FC1 ANGP1_CANLF Angiopoietin-1 (ANG-1) ANGPT1 Canis lupus familiaris (Dog) (Canis familiaris) angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; Tie signaling pathway [GO:0048014] collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] receptor tyrosine kinase binding [GO:0030971] GADFSTKDADNDNCMCKCALM 1 4.2 0.97552 0.047166 0 0 0 6.31609 0 0 0 0 0 0 0 0 8.25531 0 0 Q64H34 CCR3_CANLF C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (CD antigen CD193) CCR3 CMKBR3 Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204] cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897] C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493] ESQKESEQFVCTPLY;LDVAMQITEVIAYT;VVILTKYK 3 10.3 0.99267 -0.14342 0 0 0 0 0 0 0 0 8.66576 0 9.00689 7.69627 0 0 0 Q659L1 FUT9_CANLF 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase) FUT9 Canis lupus familiaris (Dog) (Canis familiaris) fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; Lewis x epitope biosynthetic process [GO:0106402]; neuron differentiation [GO:0030182]; neuronal stem cell division [GO:0036445]; polysaccharide biosynthetic process [GO:0000271]; positive regulation of neuron projection development [GO:0010976]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte cell-cell adhesion [GO:1903037]; regulation of leukocyte tethering or rolling [GO:1903236] Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588] 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; protein homodimerization activity [GO:0042803] LTVSTNPFVFEVPSKE 1 4.5 0.93764 0.071695 0 0 0 0 9.76157 0 0 0 0 0 0 0 0 0 0 Q659L3 Q659L3_CANLF Fucosyltransferase (EC 2.4.1.-) fut356 Canis lupus familiaris (Dog) (Canis familiaris) protein glycosylation [GO:0006486] Golgi cisterna membrane [GO:0032580] fucosyltransferase activity [GO:0008417] ADAVLVHH;TWPFHHPV 2 4.6 1.0034 -2.2088 0 0 0 0 0 0 0 0 0 8.96651 0 0 0 0 10.4996 Q659X0 FUT8_CANLF "Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)" FUT8 Canis lupus familiaris (Dog) (Canis familiaris) GDP-L-fucose metabolic process [GO:0046368]; N-glycan fucosylation [GO:0036071]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] Golgi cisterna membrane [GO:0032580] alpha-(1->6)-fucosyltransferase activity [GO:0046921]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]; SH3 domain binding [GO:0017124] EYMVHVEEHF;SIMTDLYYLSQ 2 3.7 0.9875 -0.49687 0 0 9.48517 0 0 0 0 0 0 0 0 0 0 9.60457 0 Q684P7 Q684P7_CANLF 5-hydroxytryptamine receptor 7 (Serotonin receptor 7) HTR7 Canis lupus familiaris (Dog) (Canis familiaris) "chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]" dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202] G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594] STAVAFYIPMSVMLFMYYQ 1 4.5 0.94942 0.04956 0 0 0 0 0 0 0 0 0 0 0 0 4.59425 0 0 Q68AZ0 CCL4_CANLF C-C motif chemokine 4 (Small-inducible cytokine A4) CCL4 SCYA4 Canis lupus familiaris (Dog) (Canis familiaris) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335] extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] SEPWVQEYMDD 1 12 0.98289 -0.24811 0 10.4898 0 0 0 0 0 0 0 0 0 0 0 0 0 Q68V02 Q68V02_CANLF Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) p27 Canis lupus familiaris (Dog) (Canis familiaris) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930] endosome [GO:0005768]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein-folding chaperone binding [GO:0051087] RVSNGSPSLE 1 5.1 0.18966 0.76666 0 0 9.91462 9.86581 9.47393 0 10.1991 10.2232 0 9.8112 0 0 0 0 0 Q68Y88 CCL13_CANLF C-C motif chemokine 13 (Monocyte chemoattractant protein 4) (Monocyte chemotactic protein 4) (MCP-4) (Small-inducible cytokine A13) CCL13 Canis lupus familiaris (Dog) (Canis familiaris) antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; chemokine-mediated signaling pathway [GO:0070098]; eosinophil chemotaxis [GO:0048245]; inflammatory response [GO:0006954]; positive regulation of cell migration [GO:0030335] extracellular space [GO:0005615] CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009] FTCCFTFNNKKIPLQ 1 15.3 0.9951 -0.083618 0 0 0 10.0523 0 0 0 0 0 0 0 0 0 0 0 Q6A548 TERT_CANLF Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) TERT Canis lupus familiaris (Dog) (Canis familiaris) telomere maintenance via telomerase [GO:0007004] "chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; PML body [GO:0016605]; telomerase catalytic core complex [GO:0000333]; telomerase holoenzyme complex [GO:0005697]" metal ion binding [GO:0046872]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]; telomerase RNA reverse transcriptase activity [GO:0003721]; telomeric DNA binding [GO:0042162] AKRPRRSV;AWHPYPGPQGVP;AYRFHACVLQLPFNQ;DLQPYMRQFVERLQ;QRRFLRNVKKFI;VEDGALGSAAPL 6 6.5 0.98789 -0.48837 7.472 12.2217 0 9.61557 0 10.9951 0 11.3482 11.6359 0 9.11728 0 10.9669 0 11.3099 Q6BCG5 Q6BCG5_CANLF Fas-activated serine/threonine kinase FASTK Canis lupus familiaris (Dog) (Canis familiaris) mitochondrial RNA processing [GO:0000963]; regulation of mitochondrial mRNA stability [GO:0044528] mitochondrial matrix [GO:0005759]; ribonucleoprotein granule [GO:0035770] kinase activity [GO:0016301]; RNA binding [GO:0003723] QVLLGSRALRERHLGLMGY 1 19.8 0.95477 0.04941 0 0 0 0 0 0 0 0 0 0 4.07938 0 0 0 10.0225 Q6DYE7 RENI_CANLF Renin (EC 3.4.23.15) (Angiotensinogenase) REN Canis lupus familiaris (Dog) (Canis familiaris) angiotensin maturation [GO:0002003] extracellular space [GO:0005615]; membrane [GO:0016020] aspartic-type endopeptidase activity [GO:0004190] CTFGLPADTGAF;PYGNEDLCTLAL;VLTNYLDTQYYGE 3 9.2 0.98784 -0.37712 0 13.4184 0 0 0 0 0 0 0 0 0 0 0 0 8.71493 Q6E7G6 Q6E7G6_CANLF Platelet-derived growth factor receptor alpha (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) PDGFRA Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] plasma membrane [GO:0005886] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; platelet-derived growth factor alpha-receptor activity [GO:0005018] AAHTGLYT;AAVLVLLVIVIISLIVLV;AAVLVLLVIVIISLIVLVV;AVLVLLVIVIISLIVLVVI;ELTVAAAVLVLLVIVIISLI;KNEEDKLKDWEGSL;LSDVWSYGILL;LTVAAAVLVLLVIVIISLIVLVVIW;LVLLVIVIISLIVLVVIWKQKPR;LVNYLHKNRDSF;PCRTTDPETPVTLLSNDGVVH;PVPEEEDL;SELTVAAAVLVLLVIVI;SELTVAAAVLVLLVIVIISLI;TVAAAVLVLLVIVIISLIVLVV;VAAAVLVLLVIVIISLIVLV;VIVIISLIVLVVIWKQ;VLVLLVIVIISLIVLVVI;VLVLLVIVIISLIVLVVIWKQ 19 9.8 1.0031 -1.7394 6.54363 6.46826 5.79155 6.93687 3.38225 8.2406 3.31768 12.114 0 3.98094 9.26761 8.1952 10.6652 6.98185 4.49288 Q6EIZ1 K22E_CANLF "Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)" KRT2 K2E KRT2A Canis lupus familiaris (Dog) (Canis familiaris) intermediate filament organization [GO:0045109]; keratinization [GO:0031424]; positive regulation of epidermis development [GO:0045684] cytoplasm [GO:0005737]; keratin filament [GO:0045095] structural constituent of skin epidermis [GO:0030280] DAQGKLSDLEEALQQARE;PEIQNVKSQ;SGGRGSSS;SSSGGGGF;TSSSMSSS;TVSVTSSSMSSSMTSRGGFG;VTLSMDNNRSL 7 12.5 0.98555 -0.23614 0 7.19308 0 0 0 0 0 8.73813 0 0 0 0 0 0 0 Q6IG20 Q6IG20_CANLF Reticulon RTN4 Canis lupus familiaris (Dog) (Canis familiaris) brain development [GO:0007420]; endoplasmic reticulum tubular network formation [GO:0071787]; neuron differentiation [GO:0030182] endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; postsynaptic density [GO:0014069] IKELRPSFLVDDLS 1 8.2 0.98801 -0.26079 0 0 0 0 0 0 10.8931 0 0 0 0 0 0 0 0 Q6J3Q9 Q6J3Q9_CANLF Copper-transporting ATPase beta subunit ATP7B Canis lupus familiaris (Dog) (Canis familiaris) copper ion export [GO:0060003]; copper ion import [GO:0015677]; intracellular copper ion homeostasis [GO:0006878] plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802] ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; copper ion binding [GO:0005507]; P-type divalent copper transporter activity [GO:0043682] LSSLQLKCYKKPDLERYEAQA;LVAIDGVLCGMIAIADTVKQ;VGIPIAAGV 3 21.5 0.99623 -0.099841 0 0 0 0 13.6869 0 0 0 0 0 0 0 0 0 0 Q6JDI0 Q6JDI0_CANLF Protein phosphatase 2 regulatory subunit A alpha isoform PPP2R1A Canis lupus familiaris (Dog) (Canis familiaris) LKKLVEKFGKEW 1 27.9 0.95229 0.05044 0 0 0 0 0 0 9.12446 0 0 0 0 0 0 0 0 Q6JLC9 ZN331_CANLF Zinc finger protein 331 ZNF331 Canis lupus familiaris (Dog) (Canis familiaris) regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]" EKPFEQKEGAEASIQ 1 3.1 0.94876 0.053909 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.57731 Q6L7I9 IL21_CANLF Interleukin-21 (IL-21) IL21 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to virus [GO:0098586]; germinal center B cell differentiation [GO:0002314]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; T follicular helper cell differentiation [GO:0061470] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] DPESLPAPEDVK;RQKHRPACPSCDS 2 17.1 0.91462 0.11009 0 0 0 8.53559 0 3.98878 0 0 0 0 0 5.95273 0 0 0 Q6PVW1 Q6PVW1_CANLF Protein kinase B gamma-like protein Canis lupus familiaris (Dog) (Canis familiaris) ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674] TPPEKYDEDGMDC 1 19.7 0.94387 0.059561 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.72115 Q6Q307 Q6Q307_CANLF p2Y12 platelet ADP receptor Canis lupus familiaris (Dog) (Canis familiaris) blood coagulation [GO:0007596] membrane [GO:0016020] G protein-coupled purinergic nucleotide receptor activity [GO:0045028] GVGKVPKKKVNIKVFIIIAV;IAVFFICFVP;VGKVPKKKVNIK;VGKVPKKKVNIKVFIII;VGKVPKKKVNIKVFIIIA;VIFWINFLIVIVCYT;VIWAFMFLLSL;VPKKKVNIKVFIIIAV 8 15.6 1.0028 -0.84121 0 0 6.63842 0 0 5.52428 3.32102 0 3.38198 0 0 11.5157 0 7.08215 0 Q6SLL3 Q6SLL3_CANLF receptor protein serine/threonine kinase (EC 2.7.11.30) Canis lupus familiaris (Dog) (Canis familiaris) heart development [GO:0007507]; transforming growth factor beta receptor signaling pathway [GO:0007179] plasma membrane [GO:0005886]; receptor complex [GO:0043235] activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; type I transforming growth factor beta receptor binding [GO:0034713] CDFGLSLRLDPTLSVDDL;IVPRDLKS;VGTARYMAPEVL 3 27.7 1.0042 -1.1044 0 0 8.3875 0 0 0 0 0 0 0 0 0 0 0 0 Q6SLL5 CDN1B_CANLF Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) CDKN1B KIP1 Canis lupus familiaris (Dog) (Canis familiaris) G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of mitotic cell cycle [GO:0045930] cytoplasm [GO:0005737]; endosome [GO:0005768]; nucleus [GO:0005634] cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein-folding chaperone binding [GO:0051087] GSPTSERR 1 4 1.0042 -1.1044 0 0 0 0 0 0 0 0 6.58221 0 0 0 0 0 0 Q6TDU1 MGMT_CANLF Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) MGMT Canis lupus familiaris (Dog) (Canis familiaris) DNA repair [GO:0006281]; methylation [GO:0032259] nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908] AWLDAYFREPS 1 5.1 0.98696 0.035491 9.21805 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q6TN20 Q6TN20_CANLF Cathelicidin CAMP Canis lupus familiaris (Dog) (Canis familiaris) amyloid fibril formation [GO:1990000]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; innate immune response in mucosa [GO:0002227]; killing by host of symbiont cells [GO:0051873]; neutrophil activation [GO:0042119] extracellular space [GO:0005615]; specific granule [GO:0042581] lipopolysaccharide binding [GO:0001530] SILQVKKIDRLKELIT 1 9.3 0.96312 0.049233 0 0 0 5.72011 0 0 0 0 0 0 0 0 0 0 0 Q6UKZ8 GDF8_CANLF Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Canis lupus familiaris (Dog) (Canis familiaris) myoblast migration involved in skeletal muscle regeneration [GO:0014839]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of macrophage chemotaxis [GO:0010759] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802] ILRLIKPMKDGTRYTGIRS;TVDFEAFGWDWI;VIAMPAETDL 3 10.9 1.0045 -0.81681 0 0 0 0 0 0 0 0 0 0 0 0 10.4389 0 0 Q6UUT7 Q6UUT7_CANLF Microphthalmia-associated transcription factor isoform H MITF Canis lupus familiaris (Dog) (Canis familiaris) regulation of DNA-templated transcription [GO:0006355] nucleus [GO:0005634] DNA binding [GO:0003677]; protein dimerization activity [GO:0046983] DLLQHHADLPCTTTLDL;IPSTGLCSPDL 2 6.9 0.98737 -0.32007 0 0 11.2843 0 0 0 11.3079 0 0 0 0 11.7867 10.0607 0 10.9604 Q6W6S0 Q6W6S0_CANLF Olfactory receptor family 7 subfamily D Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] VLLSFFSSLLE 1 6.3 0.9848 -0.25875 0 0 0 0 0 0 7.69857 0 0 0 0 0 0 0 0 Q6W6S4 Q6W6S4_CANLF Olfactory receptor family 5 subfamily F Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] SIFSTFAGMNMVGALLVILTSY 1 10.6 0.97379 0.048172 0 0 0 0 0 0 0 0 0 0 0 0 0 6.61464 0 Q6W6S5 Q6W6S5_CANLF Olfactory receptor family 9 subfamily I Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] ALVILISYLLIIKAILK;ALVILISYLLIIKAILKVK;LVILISYLLIIKAILKVK;LVILISYLLIIKAILKVKSPGGKVK 4 13.5 0.86745 0.17949 10.4323 0 0 0 8.55121 10.3394 0 7.81615 8.44911 10.5784 0 0 8.63361 8.98288 8.79442 Q6W6T1 Q6W6T1_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AAYVPMAVSSW;LACVDISINVISM;LTIQLPFCGNNVI 3 16.6 1.0017 -0.70328 0 0 0 0 0 0 0 11.6992 0 0 0 0 0 0 0 Q6W6T2 Q6W6T2_CANLF Olfactory receptor family 7 subfamily C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YLLAVMAYDRFVAICQ 1 7.6 0.98554 -0.23575 0 0 0 0 0 0 0 0 0 0 0 0 0 11.1672 0 Q6W6T3 Q6W6T3_CANLF Olfactory receptor family 7 subfamily C Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SIHRISSALGKSKAFSTCAS 1 10 0.94769 0.055002 0 0 6.50621 0 0 0 0 0 0 0 0 0 0 0 0 Q6W6T4 Q6W6T4_CANLF Olfactory receptor family 5 subfamily D Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] HGTILFLYCVPD;LSFVDFCYSTVVTPKL 2 13.1 0.94816 0.054665 11.0395 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q6W6T5 Q6W6T5_CANLF Olfactory receptor family 4 subfamily K Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] SGLLSMSCFL 1 5 0.99942 -0.61146 0 0 0 0 0 0 5.1863 0 0 0 0 0 0 0 0 Q6W6T7 Q6W6T7_CANLF Olfactory receptor family 5 subfamily L Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] PGSGNSMD 1 3.7 1.0039 -1.1044 0 0 0 9.31127 0 0 0 0 0 0 0 0 0 2.47801 0 Q6W6T8 Q6W6T8_CANLF Olfactory receptor Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LALVHLILILRL;LFNPMLNP 2 9 0.95328 0.05044 0 0 0 4.85245 0 0 0 0 0 0 0 0 0 0 0 Q6W6T9 Q6W6T9_CANLF Olfactory receptor family 11 subfamily M Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LWSSLEGR 1 3.8 1.0047 -1.1044 0 0 0 0 0 0 0 0 0 0 0 0 0 7.87676 0 Q6W6U2 Q6W6U2_CANLF Olfactory receptor family 3 subfamily A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GCITVTIPPMLACL;LCRVPYAACISQLF 2 13.1 0.99036 -0.53571 0 0 0 0 0 0 0 0 0 0 0 0 0 9.08929 0 Q6W6U3 Q6W6U3_CANLF Olfactory receptor family 10 subfamily J Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] SVFGLPFCDAFVI;VIIHYGCASIIY;VIIHYGCASIIYL 3 12.1 0.99207 -0.54374 0 0 0 0 0 0 9.31499 13.2771 0 0 0 0 0 15.3202 0 Q6W6V3 Q6W6V3_CANLF Olfactory receptor family 2 subfamily AY Canis lupus familiaris (Dog) (Canis familiaris) odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] VLSLMAFDHYHAI 1 24.5 0.99049 -0.14616 0 0 9.57325 0 0 0 0 0 0 0 0 0 0 0 9.6825 Q6W6V9 Q6W6V9_CANLF Olfactory receptor family 2 subfamily D Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] LVSYWNIISTV;TEIILSCSFS 2 25 0.98503 -0.44727 0 0 0 0 0 0 0 0 0 9.87572 0 0 0 0 0 Q6W6W0 Q6W6W0_CANLF Olfactory receptor family 7 subfamily A Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] EVVMYFVTV;PLHYTVIMNPWFCVLLVLVAWIS 2 33.3 0.99136 -0.27541 0 0 0 0 0 0 0 11.4563 0 0 11.6294 0 9.04207 0 0 Q6W6W1 Q6W6W1_CANLF Olfactory receptor family 10 subfamily J Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] ETSGPAGIWITGNR;SVVRVCVL 2 13.8 0.98925 -0.19679 0 0 0 0 0 0 0 0 0 0 0 0 0 9.18349 10.4578 Q6W6W3 Q6W6W3_CANLF Olfactory receptor family 4 subfamily Z Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] FFHLVGGVDVFSLS;LLTTLWFFLLLVSYMVILVVV;PKPLHYVTIMSRGRC;VLKLACTDIFMLELLMISN 4 33.8 0.9487 0.053909 0 0 0 0 0 7.39823 0 0 0 0 0 0 0 0 0 Q6WIT9 HPRT_CANLF Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HPRT1 HPRT Canis lupus familiaris (Dog) (Canis familiaris) GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; positive regulation of dopamine metabolic process [GO:0045964]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166] cytoplasm [GO:0005737]; cytosol [GO:0005829] guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] FCIPHHYAED;VGYALDYNEYFR 2 10.1 0.98953 -0.2738 0 0 0 11.1877 0 12.1336 0 0 0 0 0 0 0 0 0 Q6WZ18 NGB_CANLF Neuroglobin (Nitrite reductase) (EC 1.7.-.-) NGB Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hypoxia [GO:0071456]; oxygen transport [GO:0015671]; response to hypoxia [GO:0001666] cytosol [GO:0005829]; mitochondrial matrix [GO:0005759] GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] ESLLYMLEKCLGPA 1 9.3 0.93747 0.062581 0 0 0 0 6.82056 0 0 0 0 0 0 0 0 0 0 Q6XCF7 Q6XCF7_CANLF G-protein-coupled receptor GPR34 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] VPYHAFRFVYI 1 3.5 0.99016 -0.26643 0 0 0 0 0 0 0 0 0 0 0 0 0 8.51964 0 Q6YKA4 HMGB1_CANLF High mobility group protein B1 (High mobility group protein 1) (HMG-1) HMGB1 Canis lupus familiaris (Dog) (Canis familiaris) adaptive immune response [GO:0002250]; apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; chemotaxis [GO:0006935]; DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; neutrophil clearance [GO:0097350]; positive regulation of DNA ligation [GO:0051106]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; regulation of T cell mediated immune response to tumor cell [GO:0002840]; regulation of transcription by RNA polymerase II [GO:0006357] chromosome [GO:0005694]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886] "bubble DNA binding [GO:0000405]; DNA binding, bending [GO:0008301]; four-way junction DNA binding [GO:0000400]; non-sequence-specific DNA binding, bending [GO:0044378]; supercoiled DNA binding [GO:0097100]" EDEEDEEDEEEEEDEEDEDE;GVVKAEKSKKKKEEEE;KEEEEDEEDEEDEEEEEDEEDEDE 3 16.3 0.88175 0.13874 6.87762 0 0 0 3.68269 0 0 0 7.30214 0 0 0 0 10.2633 0 Q702P6 Q702P6_CANLF Nerve growth factor beta ngfb Canis lupus familiaris (Dog) (Canis familiaris) QTRNITVDPKLFKKRRLRSPR 1 25.9 0.97551 0.047166 0 0 0 0 0 0 0 0 9.54732 0 0 0 0 0 0 Q70HQ9 Q70HQ9_CANLF Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (Na(+)-dependent ileal bile acid transporter) (Solute carrier family 10 member 2) slc10a2 SLC10A2 Canis lupus familiaris (Dog) (Canis familiaris) bile acid and bile salt transport [GO:0015721] apical plasma membrane [GO:0016324] bile acid:sodium symporter activity [GO:0008508] VLSTVLTILLAMVMFSMGC 1 5.5 0.94784 0.054576 0 0 0 0 0 0 9.2635 0 0 0 0 0 0 0 0 Q70Z58 Q70Z58_CANLF Olfactory receptor OR28E09 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LLAILAMIFGI 1 5.1 0.99616 -0.086118 0 0 0 0 0 8.46074 0 0 0 0 0 0 0 0 0 Q70Z59 Q70Z59_CANLF Olfactory receptor OR28D07 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] FFCDIPALLPLACADT 1 7.9 0.96094 0.049233 5.63894 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q70Z61 Q70Z61_CANLF Olfactory receptor OR28B11 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DIETHNRVISHVGCLIQLSF;LKLSCNDTSTTKIFMCF;LSSTISHSPRKDAV;SYTRIVSSI;TFCINVEIPHF 5 32.9 0.99869 -0.61123 0 6.84987 0 8.27221 0 0 0 0 0 5.53574 0 0 8.98416 0 9.57372 Q70Z63 Q70Z63_CANLF Olfactory receptor OR26G07 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LQTAWLMALPFCGP;LVSLRKII;YTRIIITI 3 13.9 1.0032 -2.1479 0 0 0 4.99399 0 7.43338 0 0 0 0 0 0 0 0 6.46888 Q70Z65 Q70Z65_CANLF Olfactory receptor OR26A01 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] AVCKPLHYATT;MFMYLQPSSSHSMDNDQMA 2 13.9 0.95373 0.049453 0 0 0 0 0 0 0 0 0 0 9.44491 0 0 0 8.19382 Q70Z74 Q70Z74_CANLF Olfactory receptor OR16G03 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] FACWCGGFI 1 5.7 0.98737 -0.22808 0 0 0 8.56796 8.83479 0 0 0 0 0 0 0 0 0 0 Q70Z83 Q70Z83_CANLF Olfactory receptor OR16D09 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] GVVITISSIS 1 6.2 0.98973 -0.26397 0 0 0 0 9.28494 0 0 0 0 0 0 0 0 0 0 Q70Z91 Q70Z91_CANLF Olfactory receptor OR16B09 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVYVSSFNVFFAL 1 6 0.94172 0.076027 9.31827 0 0 0 0 0 0 9.6473 0 0 0 0 0 0 0 Q70Z94 Q70Z94_CANLF Olfactory receptor OR16A10 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] DILPLMKLSC;MLTVMAYDRYVA 2 10.2 1.0013 -0.91936 0 0 0 0 0 0 0 0 10.2912 0 0 0 0 0 3.77083 Q70Z95 Q70Z95_CANLF Olfactory receptor OR16A07 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] YVSAVLLAGGPLAGILCSYTKI 1 10.2 0.9737 0.046842 8.83352 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q70Z97 Q70Z97_CANLF Olfactory receptor OR14H03 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] VLVSWIISA;YCTALGVYLSS 2 12.8 0.9894 -0.52033 0 0 0 0 0 11.7307 0 0 0 0 0 0 0 0 0 Q70ZA5 Q70ZA5_CANLF Olfactory receptor OR14A11 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] DCIMQFCFACLFGVTETFMLAAMA 1 14 0.97397 0.041303 4.84504 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q70ZB7 Q70ZB7_CANLF Olfactory receptor OR12B07 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] ISNFICEIPSL;VISNFICEIPSLFPLSCS 2 16.1 0.99409 -0.02419 0 0 0 0 0 8.7499 0 0 0 0 7.77696 0 0 0 0 Q70ZB9 Q70ZB9_CANLF Olfactory receptor OR12A10 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LVFVASFHIFLALLIILISY 1 17.9 0.96136 0.04875 0 0 0 0 0 0 0 0 5.98759 0 0 0 0 0 0 Q70ZC3 Q70ZC3_CANLF Olfactory receptor OR10H12 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] TTGVLSILTFVALVISYIIILS 1 19.8 0.97299 0.046862 0 0 0 0 6.20924 0 0 0 0 0 0 0 0 0 0 Q70ZD3 Q70ZD3_CANLF Olfactory receptor OR10F04 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] HLTVATVF;SYLLILVAIFKMNSAEGRL 2 17.3 0.95123 0.049643 0 0 0 0 0 0 0 0 0 0 0 5.96366 0 0 0 Q70ZD7 Q70ZD7_CANLF Olfactory receptor OR10C03 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] LVSLTYLYSLTT 1 7.7 0.99388 -0.12424 13.0399 0 0 0 0 0 0 0 0 13.2438 0 0 0 0 0 Q70ZD9 Q70ZD9_CANLF Olfactory receptor OR10B09 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] TTTIPKMLVNIQR 1 6 0.93896 0.059582 0 0 0 0 0 0 0 0 0 0 0 0 7.71342 0 0 Q70ZG0 Q70ZG0_CANLF Olfactory receptor OR08D07 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] VLWLSFCR 1 5.2 1.0038 -1.1044 0 0 0 8.50004 0 0 0 0 0 0 0 0 0 0 0 Q70ZG3 Q70ZG3_CANLF Olfactory receptor OR08D02 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] LLAKIKTISL 1 4.7 0.9984 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.80261 Q70ZG6 Q70ZG6_CANLF Olfactory receptor OR08C10 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] RLVFCGSNELPHYFCDL 1 10.9 0.97709 0.046227 0 0 0 0 0 0 6.30803 6.10486 0 0 0 0 0 0 0 Q70ZH1 Q70ZH1_CANLF Olfactory receptor OR08C02 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] KFITDLLTKIKTISLE;LLTKIKTI;LTNSGLIALCSFLILVSSYIVI 3 17.8 0.99261 -0.16835 0 0 0 8.17607 7.68573 0 0 6.44674 0 0 0 0 0 0 0 Q70ZH5 Q70ZH5_CANLF Olfactory receptor OR08B10 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] VRWALVLVPYLYS 1 8.3 0.98503 -0.24033 0 0 0 0 0 0 8.93431 0 0 0 0 0 0 0 0 Q70ZH6 Q70ZH6_CANLF Olfactory receptor OR08B08 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] IVLGVFPLSGTLF;TVIMNPQLCELLVL 2 17.3 0.99647 -0.58602 0 0 0 0 0 0 0 0 0 0 8.89642 0 0 0 0 Q70ZH7 Q70ZH7_CANLF Olfactory receptor OR08B05 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] GVEHCGHL 1 3.8 0.99016 -0.26592 0 0 0 0 0 7.851 0 0 0 0 0 0 0 0 0 Q70ZI7 Q70ZI7_CANLF Olfactory receptor OR04C09 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] RMNSLEGRNKALATCS 1 10.3 0.99101 -0.22087 0 0 0 0 0 0 0 0 0 0 0 10.0116 0 0 0 Q70ZJ2 Q70ZJ2_CANLF Olfactory receptor OR04B08 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] VDTSLYET 1 5.1 0.98822 -0.26074 0 0 0 0 0 0 0 0 0 0 0 10.6414 0 0 0 Q70ZJ9 Q70ZJ9_CANLF Olfactory receptor OR04A07 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] olfactory receptor activity [GO:0004984] DRVCNLLVFASWLA 1 9 0.94337 0.07627 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10.7384 Q70ZK2 Q70ZK2_CANLF Olfactory receptor OR04A01 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] PYVYSACLSL;TLFFMYVQP 2 12.2 0.98655 -0.38738 0 0 9.7614 0 0 0 0 0 0 0 0 0 0 0 0 Q70ZK3 Q70ZK3_CANLF Olfactory receptor OR07E03 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] YMVVMSPGICI 1 7.1 0.9825 -0.25153 8.70619 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q70ZK6 Q70ZK6_CANLF Olfactory receptor OR03E02 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] GSHFTVVMFF;YSSATAPK 2 8.5 1.0028 -1.7158 0 0 8.0376 0 0 0 0 0 10.3878 0 0 0 0 0 0 Q70ZK8 Q70ZK8_CANLF Olfactory receptor OR04C05 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] CGPNVIDHFSCDMYPLLELVCT 1 11.4 0.97426 0.046925 8.22376 0 0 0 0 0 0 0 0 0 0 0 0 7.502 0 Q70ZL0 Q70ZL0_CANLF Olfactory receptor OR10A04 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984] LQIRSVEGRNKAFSTCATHLTVVC 1 11.1 0.97397 0.041303 8.2674 0 9.99817 0 0 0 0 0 0 0 0 0 0 0 0 Q70ZL3 Q70ZL3_CANLF Olfactory receptor OR01C09 Canis lupus familiaris (Dog) (Canis familiaris) G protein-coupled receptor signaling pathway [GO:0007186] membrane [GO:0016020] olfactory receptor activity [GO:0004984] CHPLHYTVIINS 1 6.5 0.98377 -0.24297 0 0 0 0 0 0 9.05254 0 0 0 0 0 0 0 0 Q71DR4 CNTFR_CANLF Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha) CNTFR Canis lupus familiaris (Dog) (Canis familiaris) ciliary neurotrophic factor-mediated signaling pathway [GO:0070120] ciliary neurotrophic factor receptor complex [GO:0070110]; CNTFR-CLCF1 complex [GO:0097059]; external side of plasma membrane [GO:0009897] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] EAPHVQYERLGS 1 3.2 0.95609 0.05044 0 0 4.95117 0 0 0 0 0 0 0 0 0 0 0 0 Q75V94 CRSP1_CANLF Calcitonin receptor-stimulating peptide 1 (CRSP-1) CRSP1 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of cytosolic calcium ion concentration [GO:0051480] extracellular space [GO:0005615] calcitonin receptor binding [GO:0031716]; hormone activity [GO:0005179] LENPPDSGVR 1 7.9 0.99971 -0.61146 0 0 0 0 0 0 0 0 0 0 0 0 0 11.4717 0 Q76IQ3 TY3H_CANLF Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) TH Canis lupus familiaris (Dog) (Canis familiaris) dopamine biosynthetic process from tyrosine [GO:0006585]; heart development [GO:0007507]; hyaloid vascular plexus regression [GO:1990384]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666] axon [GO:0030424]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; synaptic vesicle [GO:0008021] iron ion binding [GO:0005506]; tyrosine 3-monooxygenase activity [GO:0004511] FETFEAQIHHLETRPV;SLGASDEEIEKLSTL;SSPMHSPEPDCCHEL 3 9.3 0.85238 0.15701 9.518 0 0 0 0 0 0 0 7.5982 0 0 0 7.85624 0 0 Q76LT7 Q76LT7_CANLF Bcl-2-like protein 1 (Apoptosis regulator Bcl-X) bcl-xL BCL2L1 Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process in bone marrow cell [GO:0071839]; cellular response to alkaloid [GO:0071312]; cellular response to amino acid stimulus [GO:0071230]; cellular response to gamma radiation [GO:0071480]; defense response to virus [GO:0051607]; dendritic cell apoptotic process [GO:0097048]; dendritic cell proliferation [GO:0044565]; ectopic germ cell programmed cell death [GO:0035234]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fertilization [GO:0009566]; germ cell development [GO:0007281]; hepatocyte apoptotic process [GO:0097284]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of developmental process [GO:0051093]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of reproductive process [GO:2000242]; neuron apoptotic process [GO:0051402]; ovarian follicle development [GO:0001541]; positive regulation of mononuclear cell proliferation [GO:0032946]; regulation of cytokinesis [GO:0032465]; regulation of growth [GO:0040008]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to cycloheximide [GO:0046898]; response to cytokine [GO:0034097]; spermatogenesis [GO:0007283] Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; synaptic vesicle membrane [GO:0030672] BH domain binding [GO:0051400]; BH3 domain binding [GO:0051434]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901] ESEMETPS 1 3.4 0.98954 -0.26298 0 0 0 0 0 0 9.93792 0 0 0 0 0 0 0 0 Q7M2U3 Q7M2U3_CANLF Gastrotropin Canis lupus familiaris (Dog) (Canis familiaris) EVQQTGQN;SEVVGDKLVEI 2 24.7 1.0024 -1.0125 0 0 0 0 0 0 0 0 10.6087 0 0 0 0 0 8.26454 Q7YRB6 Q7YRB6_CANLF Bcl-2 bcl-2 Canis lupus familiaris (Dog) (Canis familiaris) extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] mitochondrial outer membrane [GO:0005741] protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] LSLKALLSLALVGACIT;PPVVHLTL 2 16.3 1.0036 -1.0582 0 0 0 0 0 0 0 0 5.09221 0 0 0 8.56228 0 9.07007 Q7YRF5 Q7YRF5_CANLF Cardiac titin TTN Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154] CKALVSTLEP;CSIVTTEKTCILEILNSTKKDAG;EEPYYEEPDEDYEET;EEYDEIEEYEYKESEEYEPTEEYD;EPTEEYDQYEEYEEHEFEHYE;EQYAEPFEEPYYEEPDEDYEETKVE;EYYEREEGYDEGEEEWEETYKEREV;FEEGQEYYEREEGYDEGEEEWE;FEEPYYEEPDEDYEE;KKAVPPPKVVKKP;LPPSFARKLKDVHET;PEPVKVPEIKPAIPLP;QEYYEREEGYDEGEEEWEETYKER;SPFFDIKPVSI;SQSERCSIVTTEKTCI;TLSLSLLEPS;VGAVASSAVLIIKERKLPPSFARKL;VGSDTCVA;VHEEWEEDFEEGQEYYEREEGYDEG;VSVDLALGESGSL;VTVGDSASLQCQIAGT;VYEEKKLFIE;YKESEEYEPTEEYDQYEEYEEHE 23 6.8 0.99947 -2.8594 0 0 8.43033 5.92531 0 7.60028 7.53955 8.98237 7.72397 0 10.6637 0 10.4168 10.9164 10.7765 Q7YRG2 Q7YRG2_CANLF Cardiac titin isoform N2BA TTN Canis lupus familiaris (Dog) (Canis familiaris) EEPYYEEPDEDYEET;EEYEYKESEEYEPTEEFDQYEEYEE;EPTEEFDQYEE;EQYAEPFEEPYYEEPDEDYEETKVE;EYYEREEGYDEGEEEWEETYKEREV;FEEGQEYYEREEGYDEGEEEWE;FEEPYYEEPDEDYEE;KKAVPPPKVVKKP;PEPVKVPEIKPAIPLP;QEYYEREEGYDEGEEEWEETYKER;VHEEWEEDFEEGQEYYEREEGYDEG;VYEEKKLFIE 12 14.7 0.93853 0.071029 0 8.27719 0 0 0 4.38647 0 0 0 0 0 0 0 0 0 Q7YRI1 Q7YRI1_CANLF FUN14 domain-containing protein 2 (Hepatitis C virus core-binding protein 6) Canis lupus familiaris (Dog) (Canis familiaris) autophagy of mitochondrion [GO:0000422] mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634] GVSFVKKNVLGTGGFFGGFLV 1 16.9 0.97717 0.047759 0 0 5.04566 0 0 0 0 0 0 0 0 0 0 0 0 Q7YRJ7 SOX9_CANLF Transcription factor SOX-9 SOX9 Canis lupus familiaris (Dog) (Canis familiaris) cAMP-mediated signaling [GO:0019933]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate specification [GO:0001708]; cellular response to BMP stimulus [GO:0071773]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to heparin [GO:0071504]; cellular response to mechanical stimulus [GO:0071260]; chondrocyte differentiation [GO:0002062]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; chondrocyte hypertrophy [GO:0003415]; chromatin remodeling [GO:0006338]; cochlea morphogenesis [GO:0090103]; endocardial cushion morphogenesis [GO:0003203]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in prostatic bud elongation [GO:0060517]; epithelial to mesenchymal transition [GO:0001837]; ERK1 and ERK2 cascade [GO:0070371]; growth plate cartilage chondrocyte growth [GO:0003430]; hair follicle development [GO:0001942]; heart development [GO:0007507]; heart valve development [GO:0003170]; heart valve morphogenesis [GO:0003179]; intestinal epithelial structure maintenance [GO:0060729]; male germ-line sex determination [GO:0019100]; metanephric nephron tubule formation [GO:0072289]; morphogenesis of a branching epithelium [GO:0061138]; morphogenesis of an epithelium [GO:0002009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of immune system process [GO:0002683]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest cell fate specification [GO:0014036]; nucleosome assembly [GO:0006334]; oligodendrocyte differentiation [GO:0048709]; otic vesicle formation [GO:0030916]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of kidney development [GO:0090184]; positive regulation of male gonad development [GO:2000020]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mesenchymal stem cell differentiation [GO:2000741]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of cartilage development [GO:0061035]; regulation of cell cycle process [GO:0010564]; regulation of cell population proliferation [GO:0042127]; regulation of cell proliferation involved in tissue homeostasis [GO:0060784]; renal vesicle induction [GO:0072034]; response to fatty acid [GO:0070542]; retina development in camera-type eye [GO:0060041]; retinal rod cell differentiation [GO:0060221]; Sertoli cell differentiation [GO:0060008]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spermatogenesis [GO:0007283]; tissue homeostasis [GO:0001894] nucleus [GO:0005634]; protein-containing complex [GO:0032991] "chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]" DKFPVCIREAVSQVLKG;PMPVRVNGSSKNKPH 2 6.2 0.98912 -0.19698 0 0 0 0 0 0 10.8638 0 0 0 11.2022 0 0 0 0 Q7YRK8 Q7YRK8_CANLF Type VII collagen Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198] collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867] AIRELSYKGGNTRT;APGSPGLQGPPGLPGQMGPSG;DEYEYSEYSVE;DQGDPGEDGRNGSPG;EPATLYRMWL;GLKGEPGETGP;GPPGLPGRIGVPG;GVGLPGARGERGE;GVKGACGL;LETIGIKT;LLGARGLTGPKGEP;LPGVKGDVGPPGSPG;LVWPFSGAASAQGVRF;PCTVHCPKG;PGASGPKG;PGISSSQQVTGLEPGISYTFSL;RGERGEPGVRGEDGRPGQ;RVSWSPVPGAT;SGGDVIRAI;TDGGPESSQ;VDEPGPGL;VVPTGPELPVGPVT 22 9.2 0.99673 -5.3055 0 11.3583 10.7322 0 14.054 11.0423 14.4622 8.95254 8.96584 0 0 6.43189 7.45516 0 8.11244 Q7YRL5 TNR5_CANLF Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Canis lupus familiaris (Dog) (Canis familiaris) B cell activation [GO:0042113]; immune response-regulating cell surface receptor signaling pathway [GO:0002768] CD40 receptor complex [GO:0035631]; external side of plasma membrane [GO:0009897] signaling receptor activity [GO:0038023] DLEEFPMPPHSI;DSQCCNMC;LVNDCLHTIDTE;RLRALVVVPIIMGILLVVLLV 4 19.3 1.0019 -1.2612 7.35562 0 0 0 9.42673 0 0 0 0 0 0 0 0 7.67051 8.06102 Q862Z3 UROM_CANLF "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Canis lupus familiaris (Dog) (Canis familiaris) antibacterial innate immune response [GO:0140367]; defense response to Gram-negative bacterium [GO:0050829]; neutrophil migration [GO:1990266] apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; extracellular space [GO:0005615]; membrane [GO:0016020]; side of membrane [GO:0098552]; spindle pole [GO:0000922] calcium ion binding [GO:0005509] ATPSSNATDPLKYFIIQDRCPRTT;EDCKSHDGMWSCQCKQDFN;LYLADEIVI;SECHSNATCMEDGMVTTCSCLV 4 11.5 0.58986 0.37197 0 0 0 9.11085 0 4.64731 0 0 0 6.95489 0 0 0 10.3132 0 Q863K3 Q863K3_CANLF Ly49 Ly49 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] IVVILGILCLLLLIIVAVL 1 6.9 0.95209 0.04941 0 0 0 0 0 0 0 6.21508 6.28012 0 0 0 5.91729 0 0 Q863T4 TFF1_CANLF Trefoil factor 1 TFF1 Canis lupus familiaris (Dog) (Canis familiaris) maintenance of gastrointestinal epithelium [GO:0030277] extracellular space [GO:0005615] growth factor activity [GO:0008083] SQCKDKGCCFDNTV 1 17.3 0.94133 0.061094 0 0 0 0 0 0 11.719 11.8521 11.5829 0 0 0 0 0 11.8011 Q863Z3 Q863Z3_CANLF Serine/threonine-protein phosphatase (EC 3.1.3.16) Canis lupus familiaris (Dog) (Canis familiaris) calcineurin-NFAT signaling cascade [GO:0033173] calcineurin complex [GO:0005955]; cytosol [GO:0005829] calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018] CSYFYSSPAVCEFLQHN;TEYFTFKQECKIKY 2 7.8 0.98031 0.046227 0 0 0 0 0 0 5.36065 0 0 0 0 0 0 0 0 Q864L3 SCN2B_CANLF Sodium channel regulatory subunit beta-2 SCN2B Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle cell action potential involved in contraction [GO:0086002]; membrane depolarization during cardiac muscle cell action potential [GO:0086012] plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518] sodium channel activity [GO:0005272]; sodium channel regulator activity [GO:0017080] KQFSLNWTYQECNNCSEEMFLQFR;VGASVGGF 2 14.9 0.97249 0.041303 0 0 0 0 0 0 0 0 0 12.0667 0 0 0 0 0 Q864R3 Q864R3_CANLF Melanoma antigen recognized by T-cells Canis lupus familiaris (Dog) (Canis familiaris) melanosome [GO:0042470]; membrane [GO:0016020] STLRGRCPHEGFG 1 13.7 0.94466 0.05964 0 0 0 0 0 0 8.19687 0 0 0 0 0 0 0 0 Q864Y1 Q864Y1_CANLF Small heat shock protein B3 hspb3 Canis lupus familiaris (Dog) (Canis familiaris) cytoplasm [GO:0005737]; nucleus [GO:0005634] TQEGKSRFQILLDVVQFLPEDIII 1 18.2 0.97383 0.041303 10.0753 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q865B9 Q865B9_CANLF Toll-like receptor 9 TLR9 Canis lupus familiaris (Dog) (Canis familiaris) canonical NF-kappaB signal transduction [GO:0007249]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-6 production [GO:0032755]; regulation of primary metabolic process [GO:0080090]; toll-like receptor signaling pathway [GO:0002224] endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886] pattern recognition receptor activity [GO:0038187] LDNLPKSLRLLRLR;LGTALTRDNRHFYNQ;RLRDNYLAFFNW;VVPGFFAL 4 4.5 0.99004 -0.26383 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.1798 Q866Y9 ZACN_CANLF Ligand-gated cation channel ZACN (Zinc-activated channel) ZACN LGICZ Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495] extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; ligand-gated monoatomic cation channel activity [GO:0099094]; pH-gated monoatomic ion channel activity [GO:0160128]; transmembrane signaling receptor activity [GO:0004888] APRLLLLLLAF;FNQPQGVQ;LLVDVQVFV;RARVGPDGHVDLYL 4 10.3 1.0028 -0.98417 0 0 0 0 0 0 0 0 9.65632 0 12.6888 0 0 0 0 Q8HY81 CATS_CANLF Cathepsin S (EC 3.4.22.27) CTSS Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; immune response [GO:0006955]; positive regulation of apoptotic signaling pathway [GO:2001235]; proteolysis involved in protein catabolic process [GO:0051603] extracellular space [GO:0005615]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335] cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197] GVYYEPSCTQNV;SNSNQKLPDSVDWR;TEVKYQGSCGACWAFSAVGALE;VMLHNLEHSMGMHSYDLGM;YAVAQVHKDP 5 23.3 1.0036 -1.0686 0 12.019 0 0 0 0 0 0 9.0743 0 0 0 5.66499 0 0 Q8HYB0 Q8HYB0_CANLF 5-hydroxytryptamine receptor 1A (Serotonin receptor 1A) HTR1A Canis lupus familiaris (Dog) (Canis familiaris) regulation of behavior [GO:0050795]; regulation of hormone secretion [GO:0046883]; regulation of vasoconstriction [GO:0019229] dendrite [GO:0030425]; plasma membrane [GO:0005886] G protein-coupled serotonin receptor activity [GO:0004993] EPGGREWRQGPGSKAGGPL;ISDVTFSYQV;RIFRAARFRIRKTVKKAERKGADA 3 12.5 0.95016 0.059035 0 0 0 0 0 0 13.1248 0 13.1138 6.20314 0 0 12.551 12.6109 12.2355 Q8HYB7 PERT_CANLF Thyroid peroxidase (TPO) (EC 1.11.1.8) TPO Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] extracellular space [GO:0005615]; membrane [GO:0016020] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601] DRFWWESSGVFTDEQ;HVLYSGFPLPPVR;LLRGLLASPAKLPV;NTALARWLPPAYE;PLACVPEP;SRFPQDFEPC 6 7.7 1.0017 -1.807 0 15.2314 15.1419 14.0008 0 7.67108 15.4207 15.5083 0 10.4926 0 8.45306 0 0 15.1724 Q8HZP0 Q8HZP0_CANLF B1 bradykinin receptor Canis lupus familiaris (Dog) (Canis familiaris) calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612] external side of plasma membrane [GO:0009897] bradykinin receptor activity [GO:0004947]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493] DDAPEAWDLLH;HILASLRGRP;RAPLELLPLNRSQLS 3 11.2 0.98614 -0.45175 0 0 0 0 2.99115 0 6.49954 12.4188 11.0808 0 0 0 0 0 0 Q8MI40 Q8MI40_CANLF AchR epsilon subunit CHRNE Canis lupus familiaris (Dog) (Canis familiaris) monoatomic ion transport [GO:0006811] membrane [GO:0016020] VLFGVGSC 1 16.3 1.0039 -1.1044 0 0 0 0 0 0 0 0 8.57773 0 0 0 0 0 0 Q8MIM7 Q8MIM7_CANLF Vomeronasal type-1 receptor VN1R4 Canis lupus familiaris (Dog) (Canis familiaris) response to pheromone [GO:0019236]; sensory perception of chemical stimulus [GO:0007606] plasma membrane [GO:0005886] pheromone receptor activity [GO:0016503] LHFTGCRARCTDLIL;PLSVIGKW;SMSAFFTMCFPFLSPF 3 12.3 0.99417 -0.16182 0 0 0 0 0 0 0 7.22275 0 0 4.8473 13.0174 0 0 0 Q8MIP5 Q8MIP5_CANLF Melanin-concentrating hormone receptor subtype 2 Canis lupus familiaris (Dog) (Canis familiaris) plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930] AEPLNKSCNKEFAYHTLSI 1 5.8 0.9512 0.049666 0 0 0 0 8.78741 0 0 0 0 0 4.43249 0 0 0 0 Q8MJ04 RP1_CANLF Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog) RP1 Canis lupus familiaris (Dog) (Canis familiaris) axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601] axoneme [GO:0005930]; microtubule associated complex [GO:0005875]; photoreceptor outer segment [GO:0001750] microtubule binding [GO:0008017] ELTEELERINK;HHSVQNYIQRWLQNTNP;HLSVMHPVVAKKIS;IVDSLTSDNK;PIYKKDRSVVSCNNNGF;TNQKMLEMSHNNG 6 3.8 1.0016 -0.69968 0 0 5.79491 0 8.95108 0 12.1579 0 0 0 6.34062 3.46976 0 0 0 Q8MJ43 Q8MJ43_CANLF Protein phosphatase 2A inhibitor 2 Canis lupus familiaris (Dog) (Canis familiaris) nucleosome assembly [GO:0006334] chromatin [GO:0000785]; nucleus [GO:0005634] chromatin binding [GO:0003682]; histone binding [GO:0042393] DDDDDDDDDDEGEEGE;DEDDDDDD;DEDDDDDDDDDDDEG;DEGEDEDDDDDDDDDD;DEGEDEDDDDDDDDDDDEGEEG;DVDDDDDDEGLEDIDERDEG;EDDDDDDD;EDDDDDDDDDDD;EDEDDDDDD;EDEDDDDDDDDDDDE;EDEDDDDDDDDDDDEGE;EDEDDDDDDDDDDDEGEEGE;GEDEDDDDDDDDDDDEG;IDERDEGEDEDDDDDDDDDDDEGE;VPDTDEEEEEEEEEEEDVDDDDDDE 15 18.9 0.97875 0.035538 0 0 0 0 0 0 0 4.95252 0 0 0 0 0 0 0 Q8MJZ1 Q8MJZ1_CANLF Polymeric immunoglobulin receptor Canis lupus familiaris (Dog) (Canis familiaris) EDTIGEKSNVDLQ;IDHLTQNDSGRYK;SDGYVSKDYEGR;TVIDSTGEVNF;VGGSVAVF 5 15.8 0.98177 0.035491 0 0 0 0 0 0 0 0 9.99379 0 0 0 0 0 0 Q8MKF9 Q8MKF9_CANLF Retinitis pigmentosa GTPase regulator RPGR Canis lupus familiaris (Dog) (Canis familiaris) EEREGELEGEEEEGEEEGEEKGEAG;EWGVREREEKDTEEE;GELEEEGEGELEEGEGK;REEEVGEEEET;VGEEEETEGEGDKEGEE;VGEEEGEGEEEEEGE;VGEEEGEGEEEEEGEEEEGEE 7 17.3 0.97895 0.035538 0 0 0 8.03045 0 0 0 0 0 0 0 0 0 0 0 Q8SPS5 Q8SPS5_CANLF Periplakin Canis lupus familiaris (Dog) (Canis familiaris) cytoskeleton [GO:0005856] EEERHRRQVL;KQKEEELSHVK;LEEERHRRQVL;PQQAREHALLKVQL;TLTHRVGLIDWNMFVKLRSQE 5 8.2 0.97782 0.047591 0 7.59917 0 0 0 0 0 0 0 0 0 0 0 0 0 Q8SQ02 Q8SQ02_CANLF Pregnane X receptor PXR Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nuclear receptor activity [GO:0004879] MSDAAVEQRRALIRRKKR 1 5.5 0.97349 0.048313 0 0 0 0 0 0 0 0 0 0 0 0 0 7.98254 0 Q8SQ03 CRX_CANLF Cone-rod homeobox protein CRX Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; visual perception [GO:0007601] nucleus [GO:0005634] "DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor binding [GO:0016922]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" ASESPLPEAQRGG;LEELEALFAKTQYPDVYAREEV 2 11.7 0.98973 -0.20262 9.23551 0 0 0 0 0 0 0 9.77202 0 0 0 0 0 0 Q8SQH3 Q8SQH3_CANLF Toll-like receptor 4 TLR4 Canis lupus familiaris (Dog) (Canis familiaris) inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] early endosome [GO:0005769]; membrane [GO:0016020]; ruffle [GO:0001726] transmembrane signaling receptor activity [GO:0004888] HLERVSQESFVS;LDTLAYEP;LESFDNSLLE 3 4.7 1.002 -0.6615 0 0 0 0 0 0 0 11.2248 0 0 0 0 10.6054 0 10.8782 Q8WMD0 COMD1_CANLF COMM domain-containing protein 1 (Protein Murr1) COMMD1 MURR1 Canis lupus familiaris (Dog) (Canis familiaris) copper ion homeostasis [GO:0055070]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; positive regulation of protein ubiquitination [GO:0031398]; protein transport [GO:0015031]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nucleus [GO:0005634]; recycling endosome [GO:0055037] copper ion binding [GO:0005507] KSGQESEFLCLEF 1 6.9 0.66008 0.31649 0 0 12.7064 12.0614 0 12.9542 0 13.748 0 0 12.791 0 0 0 0 Q8WMU5 FZD6_CANLF Frizzled-6 (Fz-6) FZD6 Canis lupus familiaris (Dog) (Canis familiaris) canonical Wnt signaling pathway [GO:0060070]; nervous system development [GO:0007399]; non-canonical Wnt signaling pathway [GO:0035567] apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147] EMFTFLLTCVFLP;NKVEGDNISGV;SESRRVLQESCEFFL 3 5.5 0.99074 -0.51091 0 0 0 0 0 0 0 8.78669 0 0 0 0 0 0 0 Q8WN22 PRKDC_CANLF DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC Canis lupus familiaris (Dog) (Canis familiaris) DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; rhythmic process [GO:0048511]; small-subunit processome assembly [GO:0034462]; telomere maintenance [GO:0000723] DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleus [GO:0005634]; small-subunit processome [GO:0032040] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; histone H2AXS139 kinase activity [GO:0035979]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; U3 snoRNA binding [GO:0034511] AAKQYNEALNKEE;EGGGGSCD;EKKHVSLNKVKKRRRPRGFPPSA;EPFYRETYLPYMI;ETIDVLKSRF;FIEMKPVIYL;HVSLNKVKKRR;LASGLLELAFAFGGLCEHL;LATPVGVPKDEVL;LLELAFAFGGLCEHLVDLL;LLVFVRKSL;LVVSENNGGEGIH;SECEFQEYTIDSDWR;SVDNENPPDLNKMWSEPFYRETYL;VLCRAEEITN;VYRMFKRDDLLSNVTRQAFVD 16 4.7 0.99686 -4.1917 12.3643 12.4862 7.58804 13.9536 2.20057 0 5.97655 0 9.93854 0 0 6.89276 0 0 0 Q8WNU6 Q8WNU6_CANLF Multidrug resistance p-glycoprotein MDR1 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] ABC-type oligopeptide transporter activity [GO:0015421]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887] VLSSEYSIGQVL 1 1.8 0.99133 0.0027816 0 0 0 0 0 11.7457 12.2976 0 0 0 0 0 0 0 0 Q95156 OLF3_CANLF Olfactory receptor-like protein OLF3 Canis lupus familiaris (Dog) (Canis familiaris) detection of chemical stimulus involved in sensory perception of smell [GO:0050911] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LGLSSDWDT;VDTSSNEIAIMVSSIVLLM 2 8.8 0.9498 0.049713 0 0 0 0 4.99073 0 0 0 0 0 0 0 0 0 0 Q95157 OLF4_CANLF Olfactory receptor-like protein OLF4 Canis lupus familiaris (Dog) (Canis familiaris) signal transduction [GO:0007165] plasma membrane [GO:0005886] G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984] LVSWIMSALH;VSWIMSAL 2 3.2 0.99632 -0.58028 0 0 0 0 0 10.5199 0 0 0 0 0 0 0 0 0 Q95166 Q95166_CANLF Metalloproteinase 9 Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508]; single fertilization [GO:0007338] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] VGGNSAGE 1 7.2 1.0041 -1.1044 0 0 0 0 0 0 0 0 11.5872 0 0 0 0 0 0 Q95167 KCNB2_CANLF Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2) KCNB2 Canis lupus familiaris (Dog) (Canis familiaris) action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659] dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251]; protein heterodimerization activity [GO:0046982] IVSNLFIVLSTIAL;LSVGQELDYWGIDEI;QIFRIMRILRILKL;STKDSADD;VIDLLAILPY 5 7.5 1.002 -1.265 0 0 0 0 0 0 0 0 7.32373 0 12.477 0 0 0 5.21276 Q95JD6 Q95JD6_CANLF Sulfotransferase (EC 2.8.2.-) Canis lupus familiaris (Dog) (Canis familiaris) catecholamine metabolic process [GO:0006584] cytoplasm [GO:0005737] sulfotransferase activity [GO:0008146] ERDYEKKMKGSTL;LLQFLEKDLSEETVD;SIAEEWSQVESFEAR;YYYFYQMAKIHPKAGTWEEFLDKFM 4 23.1 0.80049 0.21091 3.28186 0 0 0 0 0 11.1687 0 6.83807 0 0 0 0 6.59898 0 Q95KM5 CLD3_CANLF Claudin-3 CLDN3 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; epithelial cell morphogenesis [GO:0003382] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] QITWEGLWMNCVV 1 6 0.93836 0.059848 0 0 0 0 0 0 0 0 0 3.45483 0 0 0 0 0 Q95KM6 CLD2_CANLF Claudin-2 CLDN2 Canis lupus familiaris (Dog) (Canis familiaris) bicellular tight junction assembly [GO:0070830]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell-cell adhesion [GO:0098609]; innate immune response in mucosa [GO:0002227]; paracellular transport [GO:0160184]; regulation of bile acid secretion [GO:0120188]; regulation of intestinal D-glucose absorption [GO:1903985]; regulation of intestinal lipid absorption [GO:1904729] bicellular tight junction [GO:0005923]; plasma membrane [GO:0005886]; tight junction [GO:0070160] identical protein binding [GO:0042802]; paracellular tight junction channel activity [GO:0160187]; structural molecule activity [GO:0005198] GLPADIQAAQAMMV 1 6.1 0.94145 0.060976 0 0 0 0 0 0 0 0 0 0 5.12213 0 0 0 0 Q95LA2 FMO1_CANLF Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase) FMO1 Canis lupus familiaris (Dog) (Canis familiaris) taurine biosynthetic process [GO:0042412] endoplasmic reticulum membrane [GO:0005789] "flavin adenine dinucleotide binding [GO:0050660]; hypotaurine dehydrogenase activity [GO:0047822]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]" KMYANRFSLLKCI;LVPEDRTQLREP;YVPNSQFLE 3 6.4 0.99568 -0.092357 0 0 0 0 0 0 10.4096 0 0 0 0 0 10.0452 0 0 Q95LF1 Q95LF1_CANLF Interleukin 13 receptor alpha chain 1 IL13Ra1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of cell population proliferation [GO:0008284] external side of plasma membrane [GO:0009897]; receptor complex [GO:0043235] cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896] AGAIIILLLYLKRLK;AGAIIILLLYLKRLKII;AGAIIILLLYLKRLKIIIF;AGAIIILLLYLKRLKIIIFP;AIIILLLYLKRLKIIIFPP;DTNYTLYYWHSSLGK;IIILLLYLKRLKIIIFPP;IVAGAIIILLLYLKRLKII;LFFQNGNLYVQ;LLLYLKRLKIII;QVIVAGAIIILLLYLKRLKIII;TQVIVAGAIIILLLYLKRLKIII;VIVAGAIIILLLYLKRLKI;VIVAGAIIILLLYLKRLKII;VIVAGAIIILLLYLKRLKIII;VIVAGAIIILLLYLKRLKIIIF;YDIYEKQTKEE 17 15.6 0.99346 -0.17398 0 0 7.39968 7.81813 9.6527 7.17991 7.24574 9.40771 9.18269 6.61128 9.98698 0 7.87725 8.84643 6.27668 Q95M37 Q95M37_CANLF UDP-glucuronosyltransferase UGT1A6 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] UDP-glycosyltransferase activity [GO:0008194] DMYFTNCQSL;GVPMVMLPLFGDQMDNAKR;LEMTSGDL;PNPVSYIPRCYTQFSD 4 10 1.002 -1.0149 0 5.80818 8.99013 0 7.40165 0 0 0 8.39506 0 9.73792 0 0 0 0 Q95MC7 Q95MC7_CANLF "Troponin T, cardiac muscle (Cardiac muscle troponin T)" Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214] troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013] EEYEEEQEEEAVEEQE 1 5.8 0.96184 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 5.31089 0 0 Q95MC8 Q95MC8_CANLF "Troponin T, cardiac muscle (Cardiac muscle troponin T)" Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214] troponin complex [GO:0005861] tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013] AEEYEEEQEEEDWREHD 1 5.8 0.97709 0.046227 0 0 0 0 0 0 0 0 0 0 0 0 8.99489 0 0 Q95MC9 Q95MC9_CANLF "Troponin T, cardiac muscle (Cardiac muscle troponin T)" Canis lupus familiaris (Dog) (Canis familiaris) cardiac muscle contraction [GO:0060048]; muscle filament sliding [GO:0030049]; negative regulation of ATP-dependent activity [GO:0032780]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] striated muscle thin filament [GO:0005865]; troponin complex [GO:0005861] actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013] VEEEEDWREHDDEQ 1 4.7 0.93655 0.060769 0 0 0 0 0 0 0 7.79071 0 0 0 0 0 0 0 Q9BD74 Q9BD74_CANLF MHC class II antigen beta chain DLA-DRB1 Canis lupus familiaris (Dog) (Canis familiaris) antigen processing and presentation [GO:0019882]; immune response [GO:0006955] MHC class II protein complex [GO:0042613] NREEHVRFDSDVGEYRAVTEL;VGEYRAVT;YWNRQKELLERRRAEVDTYCRHNYR 3 51.7 0.97904 0.035538 0 0 0 0 4.663 0 6.18988 0 0 0 0 0 0 0 0 Q9BDC0 Q9BDC0_CANLF Pro-opiomelanocortin (Corticotropin-lipotropin) Canis lupus familiaris (Dog) (Canis familiaris) neuropeptide signaling pathway [GO:0007218] extracellular region [GO:0005576] hormone activity [GO:0005179] ENPRKYVMGHFRWDRFGR;VGFMSSERSQTPLV 2 14.5 0.98138 -0.24891 0 0 0 0 0 0 7.06286 0 0 0 0 0 0 0 0 Q9BDQ4 Q9BDQ4_CANLF B2 bradykinin receptor Bdkrb2 BDKRB2 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid secretion [GO:0050482]; G protein-coupled receptor signaling pathway [GO:0007186]; intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1990127]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator [GO:1902239]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; response to salt stress [GO:0009651]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310]; vasodilation [GO:0042311] endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886] bradykinin receptor activity [GO:0004947]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; type 1 angiotensin receptor binding [GO:0031702] PTTASLSTEMFNST 1 3.6 0.98987 -0.19884 0 0 0 0 0 0 0 0 0 0 10.196 0 0 0 0 Q9BDX4 IL3_CANLF Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor) IL3 Canis lupus familiaris (Dog) (Canis familiaris) immune response [GO:0006955]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] extracellular space [GO:0005615] cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; interleukin-3 receptor binding [GO:0005135] DFQRKLKKYLEAL;LDVFLNASSKFHKNGLL 2 21 0.93256 0.10579 0 0 0 0 0 0 6.8009 0 0 0 0 5.10848 0 0 0 Q9GK57 Q9GK57_CANLF Sodium bicarbonate cotransporter isoform 1 NBC1 Canis lupus familiaris (Dog) (Canis familiaris) monoatomic anion transport [GO:0006820]; regulation of intracellular pH [GO:0051453] basolateral plasma membrane [GO:0016323] sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452] KLISDFAIILPTLIF 1 7.1 0.95147 0.053888 0 0 0 0 0 0 0 0 0 0 0 0 0 5.30528 0 Q9GK99 Q9GK99_CANLF D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; regulation of dopamine secretion [GO:0014059]; regulation of potassium ion transport [GO:0043266]" glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] "dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]" GKPHYNYYAMLLTL;LVYIKIYIVLRRRRKRVNTKR;VYIKIYIVLRRRRKRVNTK 3 8.5 0.98668 -0.2318 0 0 0 0 0 0 0 9.86341 5.52485 0 0 0 0 0 0 Q9GKA0 Q9GKA0_CANLF D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Canis lupus familiaris (Dog) (Canis familiaris) "adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; regulation of dopamine secretion [GO:0014059]; regulation of potassium ion transport [GO:0043266]" glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886] "dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]" GKPHYNYYAMLLTL;IVTLLVYIKIYIVLRRRRKRVNTER;LVYIKIYIVLRRRRKRVNTE 3 9.4 0.99408 -0.17589 0 0 0 0 3.66937 0 0 5.95133 0 0 0 9.87689 0 0 0 Q9GKK4 GALK1_CANLF Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 Canis lupus familiaris (Dog) (Canis familiaris) galactose metabolic process [GO:0006012] cytoplasm [GO:0005737]; cytosol [GO:0005829] ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; galactose binding [GO:0005534] GVYGSRMTGGGFGGCTVTLLEA;SKEGFRRARHVV;TGGGFGGC;VESHHSLRDDY 4 11.5 1.0021 -1.3051 0 0 11.749 0 0 0 0 0 0 0 0 6.36384 3.50373 0 0 Q9GKK5 TBG1_CANLF Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) TUBG1 TUBG Canis lupus familiaris (Dog) (Canis familiaris) cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052] centrosome [GO:0005813]; cytoplasm [GO:0005737]; gamma-tubulin complex [GO:0000930]; microtubule [GO:0005874]; mitotic spindle microtubule [GO:1990498]; nucleus [GO:0005634]; polar microtubule [GO:0005827]; spindle [GO:0005819] GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200] SFFQINQLVSTIMSAST 1 3.8 0.98879 -0.22617 0 0 0 0 0 0 10.9799 0 0 0 0 0 0 0 0 Q9GL21 UACA_CANLF Uveal autoantigen with coiled-coil domains and ankyrin repeats UACA C3VS Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223] cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634] AAQGHMDE;EQFRRDEGKLVEENK;HQVKSLQQ;KQLEMEKLLLEN;LQLNEEVMVADDLESEK;LTSKNQVLQ;QENDKLKKEIFTLQK;TRNQILSMMNCWFSC;VLATQMCRPAI 9 7.8 0.95102 0.053874 0 0 0 8.38271 0 0 0 0 0 0 0 0 0 0 0 Q9GL27 TBXT_CANLF T-box transcription factor T (Brachyury protein) (Protein T) TBXT T Canis lupus familiaris (Dog) (Canis familiaris) cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756] chromatin [GO:0000785]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" AQARLIASWTPVSP;QYDASAQARLIA;TYSDNPSACLSMLQ 3 7.6 0.98824 -0.47246 0 0 0 0 10.2499 9.60857 0 0 0 0 0 7.89809 0 0 0 Q9GLD3 TFR1_CANLF Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71) TFRC Canis lupus familiaris (Dog) (Canis familiaris) intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of isotype switching [GO:0045830]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; transferrin transport [GO:0033572] external side of plasma membrane [GO:0009897]; melanosome [GO:0042470] transferrin receptor activity [GO:0004998] ITFAEKVA;LIENRFREFQLSKSWRDEHFVE;NDRIMKVEHNFL 3 5.5 1.0039 -1.6768 10.0867 0 0 0 0 0 0 0 0 0 0 4.10442 0 0 0 Q9GLF6 OREX_CANLF Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] HCRT OX PPOX Canis lupus familiaris (Dog) (Canis familiaris) eating behavior [GO:0042755]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of neurotransmitter secretion [GO:0046928]; response to starvation [GO:0042594]; sleep [GO:0030431]; temperature homeostasis [GO:0001659] cytoplasmic vesicle [GO:0031410]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]; synapse [GO:0045202] neuropeptide hormone activity [GO:0005184]; type 1 orexin receptor binding [GO:0031771]; type 2 orexin receptor binding [GO:0031772] LLLLLLLP;TLLLLLLL;VTLLLLLLLPPAL 3 10 0.94252 0.059561 0 0 0 0 0 0 0 4.32193 0 0 0 0 0 0 0 Q9GLJ9 SCAMP_CANLF Putative protein SCAMPER (Sphingolipid calcium release-mediating protein of the endoplasmic reticulum) (SCaMPER) SCAMPER Canis lupus familiaris (Dog) (Canis familiaris) sarcoplasmic reticulum membrane [GO:0033017] GVSGKGEMKQC;LSITEAPDLK;NSHCGENCFHGYEQ 3 31.8 0.99389 -0.16305 0 0 0 0 0 0 0 0 9.90901 9.45465 10.0725 0 0 0 0 Q9MYY9 KCNJ2_CANLF "Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)" KCNJ2 IRK1 Canis lupus familiaris (Dog) (Canis familiaris) potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of monoatomic ion transmembrane transport [GO:0034765] membrane [GO:0016020]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886] inward rectifier potassium channel activity [GO:0005242] ALTSKEEDDSENGV;DNADFEIVVILEG;EDDSENGV;VALTSKEEDDSENGV 4 6.6 1.0027 -1.4874 0 0 7.9596 0 8.80842 0 0 9.66285 0 0 0 0 0 0 0 Q9MZF3 Q9MZF3_CANLF NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) THOX2 Canis lupus familiaris (Dog) (Canis familiaris) cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; hormone biosynthetic process [GO:0042446]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] apical plasma membrane [GO:0016324] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; peroxidase activity [GO:0004601] GSGPGFGI;GVYMRNASCHFQM;IREVEENDHQDLVSVHIYITQLAE;KDGNGYLSFREFL;LESHGDPGS;QVLDRKLSVLRTVQLQ;TQGLPQCVPLTV;YHPFLDPSISPEF 8 8.3 0.9872 -0.49932 0 0 0 7.66149 7.98408 5.21878 9.47462 9.77947 0 7.45566 0 8.98137 0 0 8.59727 Q9MZI6 GNRHR_CANLF Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) GNRHR Canis lupus familiaris (Dog) (Canis familiaris) cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186] plasma membrane [GO:0005886] gonadotropin-releasing hormone receptor activity [GO:0004968]; peptide binding [GO:0042277] AFATSFTVCWTPYYVLGIWYWF;FFFLFALLNPCFDPL;KKLSRMKVLLKHLTLANL;VLHQDPHELQLNQ 4 20.8 0.79167 0.22194 0 8.25238 0 0 0 0 0 7.68741 6.77307 0 0 0 0 0 9.48913 Q9MZV7 CASP1_CANLF Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] CASP1 IL1BC Canis lupus familiaris (Dog) (Canis familiaris) apoptotic process [GO:0006915]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-1 beta production [GO:0032731]; protein autoprocessing [GO:0016540]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727] AIM2 inflammasome complex [GO:0097169]; IPAF inflammasome complex [GO:0072557]; NLRP1 inflammasome complex [GO:0072558]; NLRP3 inflammasome complex [GO:0072559]; plasma membrane [GO:0005886] caspase binding [GO:0089720]; cysteine-type endopeptidase activity [GO:0004197] ELDIAGMESLLEGLGY;SSGSPSGN 2 5.9 1.0037 -1.0552 0 7.7707 0 0 0 0 7.89875 0 0 0 0 0 0 0 0 Q9N0T0 Q9N0T0_CANLF T-cell co-stimulatory protein B7-1 B7-1 Canis lupus familiaris (Dog) (Canis familiaris) T cell costimulation [GO:0031295] membrane [GO:0016020] coreceptor activity [GO:0015026] DEVVLAVTSGQ;DYTAKWRTPLLKHPYLKV 2 12.3 0.99454 -0.15477 9.57027 8.2133 0 0 0 0 0 0 0 0 0 0 0 0 0 Q9N0Y3 MX1_CANLF Interferon-induced GTP-binding protein Mx1 (Myxoma resistance protein 1) (Myxovirus resistance protein 1) MX1 Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; innate immune response [GO:0045087] cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; exocytic vesicle [GO:0070382]; perinuclear region of cytoplasm [GO:0048471] GTP binding [GO:0005525]; GTPase activity [GO:0003924] SDPSEVEVEINKAQDAI;VALPRGSGIVTRCP 2 4.7 0.9966 -0.57523 0 0 0 0 0 0 0 0 0 0 0 0 0 9.12474 0 Q9N1Q3 Q9N1Q3_CANLF Y-box protein ZONAB-A ZONAB Canis lupus familiaris (Dog) (Canis familiaris) regulation of gene expression [GO:0010468] nucleus [GO:0005634] nucleic acid binding [GO:0003676] AGEIGEMKE;EGVPEGTQLQ;GEATGTTSSSSSSL 3 10.5 1.0034 -1.7014 0 9.14995 0 0 0 0 0 0 0 8.49905 0 0 0 0 0 Q9N262 Q9N262_CANLF ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 2.4.99.20) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (Cyclic ADP-ribose hydrolase 1) Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] "NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; transferase activity [GO:0016740]" DTSSSEMNYQSCPHWREDC;EDTLLGYMADGLKWCGD;EEKPCCGISRKAQ;FYEILLGRCYT;TVSKRFAEDACGV 5 23.4 1.0016 -0.96338 0 0 0 0 0 11.3963 0 0 0 6.83529 10.223 10.3362 0 0 0 Q9N281 COHA1_CANLF Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen homolog] COL17A1 BP180 BPAG2 Canis lupus familiaris (Dog) (Canis familiaris) extracellular matrix organization [GO:0030198]; hemidesmosome assembly [GO:0031581] basement membrane [GO:0005604]; collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; hemidesmosome [GO:0030056]; membrane [GO:0016020] extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparin binding [GO:0008201] AGEPGVQGPPG;EAGAFGLDMGLG;GAAEGGMY;GASGGSLGE;GGGGGGGG;GVSSIPGP;GYGGAAEG;LETYFSGP;LLLTWLLLL;LPAGSSMGT;TGMPGTRGPPGPS;VIGDWSLQSLDYAEL;VLETYFSG 13 7.4 0.99701 -5.884 9.71464 7.48422 0 10.6938 0 8.59854 7.68201 0 0 10.8227 10.3401 10.2184 0 0 8.90818 Q9N2C7 Q9N2C7_CANLF Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) Canis lupus familiaris (Dog) (Canis familiaris) hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448] endoplasmic reticulum [GO:0005783]; membrane [GO:0016020] heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]; steroid binding [GO:0005496] FLRFFPNPGL;PQTPSYKL 2 3.7 1.0026 -0.72941 12.0235 12.2787 12.235 0 0 0 11.3536 11.5233 0 0 0 0 11.5125 0 0 Q9N2I9 UCP3_CANLF Putative mitochondrial transporter UCP3 (Solute carrier family 25 member 9) (Uncoupling protein 3) (UCP 3) UCP3 SLC25A9 Canis lupus familiaris (Dog) (Canis familiaris) adaptive thermogenesis [GO:1990845]; mitochondrial transmembrane transport [GO:1990542]; response to cold [GO:0009409] mitochondrial inner membrane [GO:0005743] oxidative phosphorylation uncoupler activity [GO:0017077] LDYHLLTD 1 2.6 0.99293 -0.13993 0 0 0 0 0 0 0 0 0 0 11.6758 0 0 0 0 Q9TT82 Q9TT82_CANLF Collagenase 3 (Matrix metalloproteinase-13) Canis lupus familiaris (Dog) (Canis familiaris) proteolysis [GO:0006508] extracellular matrix [GO:0031012]; extracellular region [GO:0005576] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] EVTGKLDDNTLD;PRTLKWSKTNLTYRIVNYTPDLTH 2 8 0.98963 -0.26614 0 0 0 0 0 0 0 0 0 0 0 9.19197 0 0 0 Q9TT90 ANDR_CANLF Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR NR3C4 Canis lupus familiaris (Dog) (Canis familiaris) androgen receptor signaling pathway [GO:0030521]; intracellular receptor signaling pathway [GO:0030522]; male gonad development [GO:0008584]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of protein localization to plasma membrane [GO:1903076] chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634] androgen binding [GO:0005497]; beta-catenin binding [GO:0008013]; DNA-binding transcription factor activity [GO:0003700]; estrogen response element binding [GO:0034056]; nuclear receptor activity [GO:0004879]; steroid binding [GO:0005496]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270] GSAGDGGSVAPYGYT;LICGDEASGCHYGALTCGSCK;PQKTCLICGDEASGCHYGA;QPIFLNVLEAIE;VIQNPGPRHPEAVSAA 5 7.6 0.9895 -0.21779 8.05772 9.07991 0 0 0 0 0 0 0 0 10.4462 11.7801 0 0 0 Q9TTD8 PROP1_CANLF Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor) PROP1 Canis lupus familiaris (Dog) (Canis familiaris) pituitary gland development [GO:0021983]; regulation of transcription by RNA polymerase II [GO:0006357] nucleus [GO:0005634]; transcription regulator complex [GO:0005667] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]" QPLAHLSPATFS 1 5.3 0.95211 0.05044 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.18468 Q9TTI7 PIT1_CANLF Pituitary-specific positive transcription factor 1 (PIT-1) (Growth hormone factor 1) (GHF-1) POU1F1 GHF1 PIT1 Canis lupus familiaris (Dog) (Canis familiaris) positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357] cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] "DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]" VGANERKRKRRTTISI 1 5.5 0.9613 0.049233 0 0 0 0 0 0 0 0 0 0 0 8.73478 0 0 0 Q9TTY4 MAGBA_CANLF Melanoma-associated antigen B10 (MAGE-B10 antigen) MAGEB10 Canis lupus familiaris (Dog) (Canis familiaris) negative regulation of transcription by RNA polymerase II [GO:0000122] nucleus [GO:0005634] IQMYRNHFHEIL;IYVLVNKLELSYDAMLSDDEGV;LLYKYQMK 3 11.1 1.0029 -1.007 4.7271 0 0 0 5.06536 0 6.16641 0 0 0 0 0 0 0 10.7289 Q9TTY6 Q9TTY6_CANLF Platelet-activating factor receptor Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] membrane [GO:0016020] platelet activating factor receptor activity [GO:0004992] LVTLPLWIIYYHNQG 1 5.1 0.95107 0.05389 0 0 0 0 0 4.51412 0 0 0 0 0 0 0 0 0 Q9TU16 Q9TU16_CANLF Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) PTGER4 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of inflammatory response [GO:0050729]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; T-helper cell differentiation [GO:0042093] plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] SETSDSSQGQDSE 1 2.6 0.93986 0.059703 0 7.73112 0 0 0 0 0 0 0 0 0 0 0 0 0 Q9TU19 NPHP1_CANLF Nephrocystin-1 NPHP1 NPH1 Canis lupus familiaris (Dog) (Canis familiaris) cell differentiation [GO:0030154]; cell projection organization [GO:0030030]; protein localization involved in establishment of planar polarity [GO:0090251]; spermatogenesis [GO:0007283] adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EEETEAARWKVIAD;ESEEEEEEKQENE;FQLLEEGNQ;LKLFDASGI;VLLKDRTSM 5 9.6 1.0025 -1.7939 0 0 6.70072 6.87689 0 0 0 0 0 8.23874 8.88832 9.17976 0 9.34822 0 Q9TU69 GHR_CANLF Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] GHR Canis lupus familiaris (Dog) (Canis familiaris) cytokine-mediated signaling pathway [GO:0019221]; endocytosis [GO:0006897]; growth hormone receptor signaling pathway [GO:0060396]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427] cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; growth hormone receptor complex [GO:0070195] cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; growth hormone receptor activity [GO:0004903]; peptide hormone binding [GO:0017046] AQVSDITLAGSVVL;LDIDDLDE;PVPKIKGI;TPTILGSASQSLQRV 4 7.1 1.003 -0.85972 0 8.07617 0 0 0 0 0 0 0 9.12249 0 0 0 10.8752 0 Q9TUI5 MT4_CANLF Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV) MT4 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872] GGSDKCSC;KTCRKSCCPCC 2 30.6 0.98684 -0.23043 0 0 0 0 9.4596 0 0 0 0 0 0 0 9.30387 0 0 Q9TUN7 Q9TUN7_CANLF Integrin beta GPIIIa Canis lupus familiaris (Dog) (Canis familiaris) cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] plasma membrane [GO:0005886] DTCMSSNGLLCGGRGKCECGSC;FVDKPVSPYMYIS;HVLTLTDQVT;MCSGHGQCSCGDC;MCSGHGQCSCGDCLCDSD;RARPLWAAVL;RCNLKENLLKDNCALE;TIQVTFDCDC 8 12.6 1.0006 -0.92809 0 0 0 7.58301 0 6.90171 0 0 14.8391 0 6.33612 0 9.86828 0 0 Q9TUP7 OX2R_CANLF Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Canis lupus familiaris (Dog) (Canis familiaris) "cellular response to hormone stimulus [GO:0032870]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]" plasma membrane [GO:0005886] orexin receptor activity [GO:0016499]; peptide binding [GO:0042277] DERWGGEIYPKMYH;DITETWFFGQ;DRWYAICHPLMFKST;LVYANSAANPIIYNF 4 12.2 0.99423 -0.12701 0 0 0 0 9.81369 0 0 0 0 0 9.03507 7.2937 0 0 0 Q9TVB8 RPE65_CANLF Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase) RPE65 Canis lupus familiaris (Dog) (Canis familiaris) retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]; zeaxanthin biosynthetic process [GO:1901827] endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886] "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity [GO:0052885]; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity [GO:0052884]; beta-carotene 15,15'-dioxygenase activity [GO:0003834]; cardiolipin binding [GO:1901612]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; retinol isomerase activity [GO:0050251]" NYMDCFESNETMGV;TAHPHIENDGTVY 2 5.1 0.99205 -0.54133 0 0 10.6963 0 0 0 0 0 0 0 0 0 10.8221 10.6748 10.9654 Q9XSJ8 Q9XSJ8_CANLF Kv3.1 Kv3.1 Canis lupus familiaris (Dog) (Canis familiaris) protein homooligomerization [GO:0051260] axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076] delayed rectifier potassium channel activity [GO:0005251] ADADGPGDSGDGED;ADADGPGDSGDGEDELEMT;IDQALTPDEGLPFTRSGTR;LDNSADDADAD;LSDPPDGRPGGFW;LTIAMPVPVIV;VVRFVRILRIFKLTRHFV;WALFEDPYSSRYARYVAFASLFFIL 8 19.1 0.87515 0.13358 0 0 6.71973 16.8202 9.30943 0 0 9.07658 0 8.82216 4.91466 0 7.82005 10.0305 0 Q9XSR5 Q9XSR5_CANLF RWD domain-containing protein Canis lupus familiaris (Dog) (Canis familiaris) ELEALRSIYEGD;LPGGAGGAPCSV 2 16.4 0.94094 0.10088 0 0 6.19733 0 7.12701 0 0 0 0 0 0 0 0 0 0 Q9XSR8 Q9XSR8_CANLF Uncharacterized protein Canis lupus familiaris (Dog) (Canis familiaris) CCSCACAAA 1 12.9 1.0047 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 4.45805 0 Q9XSS7 Q9XSS7_CANLF Collagen VI-alpha1 protein collagen VI-alpha1 Canis lupus familiaris (Dog) (Canis familiaris) collagen trimer [GO:0005581] GRHHHPAGRLGQR 1 8.7 0.93781 0.063801 8.82365 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q9XST0 Q9XST0_CANLF Ubiquitin carrier protein e2-EPF Canis lupus familiaris (Dog) (Canis familiaris) KKLASKKKTDKKRALRR 1 33.3 0.97747 0.046227 0 0 0 0 0 0 0 0 0 0 0 6.25831 0 0 0 Q9XST5 MT2_CANLF Metallothionein-2 (MT-2) (Metallothionein-II) (MT-II) MT2A MT2 B28 Canis lupus familiaris (Dog) (Canis familiaris) cellular response to cadmium ion [GO:0071276]; cellular response to copper ion [GO:0071280]; cellular response to zinc ion [GO:0071294]; detoxification of copper ion [GO:0010273]; intracellular zinc ion homeostasis [GO:0006882]; negative regulation of growth [GO:0045926] cytoplasm [GO:0005737]; nucleus [GO:0005634] metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] DPNCSCAA 1 13.1 1.0037 -1.1044 0 0 0 0 0 0 0 6.85898 0 0 0 0 0 0 0 Q9XSU2 Q9XSU2_CANLF Large ribosomal subunit protein eL19 (60S ribosomal protein L19) rpL19 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] NSRQQILKLIKDGLIIRKPVTVHS 1 21.2 0.97403 0.041303 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.84273 Q9XSU5 Q9XSU5_CANLF Small ribosomal subunit protein uS13 (40S ribosomal protein S18) rpS18 Canis lupus familiaris (Dog) (Canis familiaris) translation [GO:0006412] cytosolic ribosome [GO:0022626]; small ribosomal subunit [GO:0015935] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] KDGKYSQVLANGLD 1 14.4 0.94267 0.061059 0 0 0 0 0 0 0 0 0 0 6.5377 0 0 0 0 Q9XSV5 LY65C_CANLF Lymphocyte antigen 6 complex locus protein G5c (Canine epididymal gene product 8) (CE8) (Epididymal secretory protein 8) LY6G5C CE8 Canis lupus familiaris (Dog) (Canis familiaris) external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991] identical protein binding [GO:0042802] LETKELGCLLGSDICLAP 1 14.1 0.70107 0.28723 0 0 0 0 0 0 8.80142 0 0 0 0 0 0 0 0 Q9XSV6 Q9XSV6_CANLF CE9 protein ce9 Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] HMQDSEGVELQSHILLTQAMFL;NFLYRKQWQH;RALICNHPVQYRP 3 17.5 0.98659 -0.23296 0 0 0 0 0 0 10.9221 0 0 0 0 0 0 6.27966 0 Q9XT82 PE2R2_CANLF Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) PTGER2 Canis lupus familiaris (Dog) (Canis familiaris) adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of peptidyl-serine phosphorylation [GO:0033138] plasma membrane [GO:0005886] prostaglandin E receptor activity [GO:0004957] SLPFTIFAYMNETSSRREKWDLQAL 1 6.9 0.99246 -0.29515 0 0 8.9888 0 0 0 0 0 0 0 0 0 0 0 0 R9XMN7 R9XMN7_CANLF Interferon 1EA (Interferon epsilon) IF1EA Canis lupus familiaris (Dog) (Canis familiaris) defense response to virus [GO:0051607]; natural killer cell activation [GO:0030101]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427] extracellular space [GO:0005615] cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126] HSSCAWTII 1 4.8 1.0037 -0.80421 0 0 0 0 0 0 0 0 0 0 0 0 0 6.55896 5.96047 R9YZ14 R9YZ14_CANLF Amelogenin Y isoform AMELY Canis lupus familiaris (Dog) (Canis familiaris) biomineral tissue development [GO:0031214] collagen-containing extracellular matrix [GO:0062023] WLHHQIIPMLSQQNPSNQALQPHH 1 14.5 0.99406 -0.28568 0 0 0 0 0 0 0 0 11.1287 0 0 0 0 0 0 S5U7R2 S5U7R2_CANLF HSFY LOC119868754 HSFY Canis lupus familiaris (Dog) (Canis familiaris) nucleus [GO:0005634] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DEKGTSIVIDEEL;SEPEEDNDF;TTTSTSQYGIIS;VIDEELFKKEVLERKAPFRI 4 12 1.0024 -0.972 0 7.96434 0 8.79035 0 0 8.68947 9.01092 0 0 0 0 0 10.1643 0 S5U8I1 S5U8I1_CANLF KDM5D Canis lupus familiaris (Dog) (Canis familiaris) chromatin organization [GO:0006325] nucleus [GO:0005634] dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872] EEVMKRLTPELFDSQ;GVDVPEAHQLQ;HYRRLRRYCVFSHEELICKMAAF;LCQDWFHGQCVSVSHI;LLEVTLDENHR;LLTIAERWEEKA;VMKRLTPELFDSQP;YHSGFNQGYNFAEAVNFC 8 10.2 0.96202 0.049233 0 0 0 0 0 0 0 0 0 0 0 0 0 5.58244 0 T2KEN6 T2KEN6_CANLF Pentraxin family member CRP Canis lupus familiaris (Dog) (Canis familiaris) acute-phase response [GO:0006953] extracellular region [GO:0005576] metal ion binding [GO:0046872] GEVFLKKELWS 1 4.9 0.98458 0.035491 0 0 0 0 0 0 5.95965 0 0 0 0 0 0 0 0 W0UVG2 W0UVG2_CANLF Ribonuclease A L1 RAL1 Canis lupus familiaris (Dog) (Canis familiaris) extracellular region [GO:0005576] nucleic acid binding [GO:0003676] EIQKFCRYSDSFCENYNEY 1 12.4 0.95193 0.049538 0 0 0 5.50344 0 0 0 0 0 0 0 0 0 0 0 W5VNF7 W5VNF7_CANLF Sphingosine 1-phosphate receptor 1 (Sphingosine 1-phosphate receptor Edg-1) S1PR1 Canis lupus familiaris (Dog) (Canis familiaris) chemotaxis [GO:0006935] plasma membrane [GO:0005886] sphingosine-1-phosphate receptor activity [GO:0038036] TVFTLLLLAIVIL;YVNYDIIVRHYN 2 6.6 0.99351 -0.2814 0 0 0 0 0 0 0 0 0 0 10.4297 0 0 0 0 W8W3H1 W8W3H1_CANLF MAS related GPR family member F (Mas-related G protein-coupled receptor C) MGRC MRGPRF Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] PFSVYFLHLAGADVG;PVWYWRRRPKRLSAVVCTLL 2 10.7 0.91859 0.11823 0 0 0 0 0 0 0 0 10.7961 0 6.66704 0 0 0 10.4302 W8W3K8 W8W3K8_CANLF Mas-related G protein-coupled receptor H MGRH Canis lupus familiaris (Dog) (Canis familiaris) membrane [GO:0016020] G protein-coupled receptor activity [GO:0004930] AIYFFIRGSGRRQP;GEAPTQPNSGDGPLP;VRRILRIFLWSCFQLPSI 3 14.6 0.86207 0.16296 5.47194 0 0 0 0 0 0 8.08268 0 0 7.32337 0 0 0 0 X2BYI2 X2BYI2_CANLF SETDB2-PHF11 fusion protein variant 9 SETDB2-PHF11 fusion Canis lupus familiaris (Dog) (Canis familiaris) SNTKEMKSQVNL 1 12 0.94609 0.05044 0 0 0 0 0 0 0 0 0 0 9.66539 0 0 0 0 X2BZ25 X2BZ25_CANLF SETDB2-PHF11 fusion protein variant 16 SETDB2-PHF11 fusion Canis lupus familiaris (Dog) (Canis familiaris) SLDSVIKIDFSHK 1 34.2 0.9427 0.059878 0 9.14216 0 0 0 0 0 0 0 0 0 0 0 0 0 X5FV97 X5FV97_CANLF Protein FAM161A FAM161A Canis lupus familiaris (Dog) (Canis familiaris) cell projection organization [GO:0030030] cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856] EGYQKHLSEQKC;LEEREEKLKNR;SQREDPSEAATAAAAAL 3 6.2 0.98822 -0.22751 0 5.47171 0 0 0 0 0 0 5.56541 0 0 0 0 0 0 X5L571 X5L571_CANLF Cytochrome P450 (EC 1.14.14.-) Cytochrome-P450-2D15 Canis lupus familiaris (Dog) (Canis familiaris) arachidonic acid metabolic process [GO:0019369]; xenobiotic metabolic process [GO:0006805] endoplasmic reticulum membrane [GO:0005789] "heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]" PIYDHLGF;VISSLTYGRRFEY 2 4.2 1.0028 -1.0236 8.50577 0 0 0 0 10.0889 0 0 0 0 0 0 0 0 0